Chemical Carcinogenesis [electronic resource] /
Penning, Trevor M.editor.
This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.
Description based upon print version of record.
""Chapter 1: Historical Overview of Chemical Carcinogenesis""; ""1 Introduction""; ""1.1 Chemical Carcinogenesis and Human Cancer""; ""1.2 Early History of Carcinogenesis Research""; ""2 Polycyclic Aromatic Hydrocarbons""; ""2.1 Structureâ€?Activity Relationships""; ""2.2 Metabolism and Metabolic Activation""; ""2.2.1 Diol Epoxide Pathway""; ""2.2.2 Radical-Cation Pathway""; ""2.2.3 Redox-Active Quinone Pathway""; ""3 Aromatic Amines and Amides""; ""4 Nitroarenes""; ""5 Heterocyclic Aromatic Amines Formed in Cooking""; ""6 N-Nitroso Compounds""; ""6.1 N-Nitroso Compounds in the Diet""
""6.2 Tobacco-Specific N-Nitroso Compounds""""6.3 Metabolic Activation of N-Nitroso Compounds""; ""7 Naturally Occurring Carcinogens""; ""7.1 Aflatoxins""; ""7.2 Safrole, Estragole, and Related Compounds""; ""7.3 Pyrrolizidine Alkaloids""; ""8 Occupational Carcinogens""; ""9 Importance of Chemical Carcinogens in Human Cancer""; ""9.1 Identification of the Major Classes of Environmental Carcinogens""; ""9.2 Appreciation of the Role of Lifestyle Factors""; ""9.3 Recognition of the Role of Bioactivation""; ""10 Future Directions""; ""References""; ""Chapter 2: Multistage Carcinogenesis""
""1 Introduction""""2 Multistage Carcinogenesis in Mouse Skin""; ""3 Mechanisms of Skin Tumor Initiation""; ""4 Mechanisms of Tumor Promotion""; ""5 Mechanisms Associated with Tumor Progression""; ""6 Role of KSCs in Multistage Skin Carcinogenesis""; ""7 Multistage Carcinogenesis and Human Cancer""; ""8 Factors Affecting Susceptibility to Multistage Skin Carcinogenesis""; ""8.1 Genetic Background""; ""8.2 Diet/Nutritional Status""; ""9 Multistage Carcinogenesis and Cancer Prevention""; ""10 Conclusions and Perspectives""; ""References""
""Chapter 3: Tobacco Smoke Carcinogens and Lung Cancer""""1 Introduction""; ""2 Mechanistic Framework for Understanding Smoking and Lung Cancer""; ""3 Lung Carcinogens in Cigarette Smoke""; ""3.1 Polycyclic Aromatic Hydrocarbons""; ""3.1.1 Evidence""; ""3.1.2 Unresolved Issues""; ""3.2 Nitrosamines""; ""3.2.1 Evidence""; ""3.2.2 Unresolved Issues""; ""3.3 Butadiene""; ""3.3.1 Evidence""; ""3.3.2 Unresolved Issues""; ""3.4 Ethylene Oxide""; ""3.4.1 Evidence""; ""3.4.2 Unresolved Issues""; ""3.5 Ethyl Carbamate (Urethane)""; ""3.5.1 Evidence""; ""3.5.2 Unresolved Issues""
""3.6 Inorganic Compounds""""3.6.1 Evidence""; ""3.6.2 Unresolved Issues""; ""4 Other Carcinogens and Agents Possibly Related to Lung Cancer""; ""5 Insights from Inhalation Studies of Cigarette Smoke""; ""6 Summary""; ""References""; ""Chapter 4: Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products""; ""1 Risks of Estrogen Exposure""; ""2 Mechanisms of Estrogen Carcinogenesis""; ""2.1 Hormonal Mechanism""; ""2.2 Chemical Mechanism""; ""2.3 Estrogen Receptor as a Trojan Horse""; ""3 DNA Damage""; ""3.1 Oxidative DNA Damage""; ""3.2 Covalent DNA Adducts""
""4 Chemoprevention of Estrogen Carcinogenesis""
Includes bibliographical references and index.
This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.
Cancer research.
Pharmacology.
Cancer Research.
Pharmacology/Toxicology.