Pasteurella multocida [electronic resource] : Molecular Biology, Toxins and Infection /
Aktories, Klaus.editor.
Orth, Joachim H.C.editor.
Adler, Ben.editor.
It is more than 125 years since Louis Pasteur identified as the causative agent of “choléra des poules” the bacterium that now bears his name. Since that time, Pasteurella multocida has been recognized as the causative agent of a wide range of infections in a wide range of animal species as well as in humans.  Indeed, the species name multocida could be literally translated as “multi-killer”. The term pasteurellosis is now widely applied to describe infections of mammals and birds caused by P. multocida.  It is therefore surprising that a detailed knowledge of the cellular and molecular basis for pathogenesis in pasteurellosis lags behind what has been elucidated for many other bacterial species.  In particular, the molecular basis for host predilection remains completely unknown.    This volume brings together contributions from experts in the field of Pasteurella research.  It covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of Pasteurella multocida toxin and its interaction with host tissues, cells, immune system, and signalling pathways. .
Description based upon print version of record.
Pasteurella multocida; Preface; Contents; Contributors; 216 Pasteurella multocida: Diseases and Pathogenesis; Abstract; 1...Non-Specific Disease Syndromes Caused by Pasteurella multocida; 2...Specific Disease Syndromes; 3...Avian Cholera; 4...Haemorrhagic Septicaemia; 5...Atrophic Rhinitis; 6...Snuffles of Rabbits; 7...Lower Respiratory Tract Infections of Ungulates; 8...Sporadic Septicaemias Involving Different Capsular Types; 9...Mechanisms of Pathogenesis: Cellular and Molecular Aspects; 10...Resistance to Host Innate Immunity; 11...Cell Adhesion and Invasion; 12...Other Virulence-Associated Factors
AcknowledgmentsReferences; 203 Pathogenomics of Pasteurella multocida; Abstract; 1...Sequenced P. multocida Genomes; 2...Comparison of the Complete Genomes of Pm70 and 36950; 3...Analysis of the Incomplete Genome Sequences of Strains X73, VP161, Anand1P, Anand1G, P903, M1404 and P3480; 4...Plasmids Carried by P. multocida Strains; 5...Bacteriophages of P. multocida; 6...Whole-Genome Transcriptomic Analyses; 7...Proteomic Analyses; 8...Concluding Remarks; References; 202 The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide; Abstract; 1...The Capsule of Pasteurella multocida
2...Chemical Structure of Pasteurella multocida Capsules3...Genetics of Capsule Biosynthesis; 4...Regulation of Capsule Production; 5...The Role of Capsule in Virulence; 6...The Lipopolysaccharide of Pasteurella multocida; 7...The LPS Inner Core Structure; 8...Genetics and Assembly of the LPS Inner Core; 9...The LPS Outer Core; 10...The Role of LPS in Virulence; 11...The Role of LPS in Immunity; Acknowledgments; References; 204 Pasteurella Multocida and Immune Cells; Abstract; 1...Introduction; 1.1 How the Immune System Fights Bacterial Infections; 1.2 Bacterial Strategies of Immune Evasion
2...Pasteurella multocida and Immune Cells2.1 Pasteurella multocida-Associated Diseases; 2.2 Major Virulence Factors of Pasteurella multocida; 2.2.1 LPS; 2.2.2 Capsule; 2.2.3 Adhesins; 2.2.4 Outer Membrane Proteins and Porins; 2.2.5 Pasteurella multocida Toxin; 2.2.6 Aspects of PMT in Osteoimmunology; 3...Discussion; Acknowledgments; References; 201 Molecular Biology of Pasteurella multocida Toxin; Abstract; 1...Structure of PMT; 2...Uptake into Eukaryotic Cells; 3...Activation of Heterotrimeric G Proteins; 4...Substrate Specificity; 5...G Protein Prerequisites for PMT Action; 5.1 Role of G beta gamma
5.2 PMT-Induced Activation of G Proteins is Independent of GPCR Interaction6...PMT and Cytotoxic Necrotizing Factors; 7...Outlook; Acknowledgments; References; 219 Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects; Abstract; 1...Introduction; 2...PMT Structure and Function; 3...Cellular Uptake of PMT; 3.1 Binding to Host Cells; 3.2 Trafficking in Cells; 3.3 Translocation Across Cell Membranes; 4...Effects on Cell Signaling; 4.1 Cellular Responses; 4.2 Calcium Signaling; 4.3 Mitogenic Signaling; 4.4 Cytoskeletal Signaling; 4.5 cAMP Signaling; 4.6 Adipogenic Signaling
4.7 Osteogenic Signaling
Includes bibliographical references and index.
It is more than 125 years since Louis Pasteur identified as the causative agent of “choléra des poules” the bacterium that now bears his name. Since that time, Pasteurella multocida has been recognized as the causative agent of a wide range of infections in a wide range of animal species as well as in humans.  Indeed, the species name multocida could be literally translated as “multi-killer”. The term pasteurellosis is now widely applied to describe infections of mammals and birds caused by P. multocida.  It is therefore surprising that a detailed knowledge of the cellular and molecular basis for pathogenesis in pasteurellosis lags behind what has been elucidated for many other bacterial species.  In particular, the molecular basis for host predilection remains completely unknown.    This volume brings together contributions from experts in the field of Pasteurella research.  It covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of Pasteurella multocida toxin and its interaction with host tissues, cells, immune system, and signalling pathways. .
Pharmacology.
Medical microbiology.
Pharmacology/Toxicology.
Medical Microbiology.
Current topics in microbiology and immunology