Computational Strategies Towards Improved Protein Function Prophecy of Xylanases from Thermomyces lanuginosus [electronic resource] /
Karthik, MVK.author.
Shukla, Pratyoosh.author.
This Brief reports on the interplay of an amino-acid mutation towards substrate which could lead to enhanced effects on mutant. These effects need  to  be given consideration in  the  engineering  processes of protein stability and further exploration of such learning are required to provide novel indication for selection of an enzymes.  There  are  very  few  reports  showing  such  stable,  energy  efficient  model  towards  improved  protein function prediction screening in-silico structure based mutagenesis of xylanases from Thermomyces lanuginosus.
Description based upon print version of record.
Computational StrategiesTowards Improved Protein Function Prophecy of Xylanases fromThermomyces lanuginosus; Contents; Abstract; 1 Introduction; 1.1...Introduction; References; 2 Background; 2.1...Protein Structure; 2.1.1 Classification of Protein Structure; 2.1.2 Protein Surface; 2.2...Protein--Protein Interaction; 2.3...Protein Binding Site Prediction; 2.3.1 Identification of Protein--Ligand Binding Site; 2.3.2 Protein--Protein Binding Site Prediction; 2.3.2.1 Surface Patch-Based Prediction Methods; 2.3.2.2 Machine Learning Prediction Approaches; 2.4...Protein--Protein Docking
2.4.1 Rigid-Body Docking2.4.2 Fast Fourier Transform; 2.4.3 Benchmark for Testing the Docking Algorithms; 2.4.4 Critical Assessment of Predicted Interactions; 2.4.5 Protein Interface Prediction and Protein Docking; 2.5...Flexible Docking; 2.5.1 Side-Chain Flexibility; 2.5.2 Backbone Flexibility; 2.5.3 Soft Docking; References; 3 Materials and Methods; 3.1...Selection of Sequences, 3D Structures and Multiple Sequence Alignment; 3.2...Mutant Generation; 3.3...Energy Minimization; 3.4...Stereo-Chemical Quality Check and Analysis of Non-Bonded Interactions; 3.5...Protein--Protein Docking; 3.6...InterProScan
3.7...Identification of Functionally Important Regions of Wild Type viz. Endo-1, 4-beta xylanases3.8...3d2GO Server: From Protein 3D Structure to Gene Ontology Term; References; 4 Results and Discussions; 5 Conclusion; References
Includes bibliographical references.
This Brief reports on the interplay of an amino-acid mutation towards substrate which could lead to enhanced effects on mutant. These effects need  to  be given consideration in  the  engineering  processes of protein stability and further exploration of such learning are required to provide novel indication for selection of an enzymes.  There  are  very  few  reports  showing  such  stable,  energy  efficient  model  towards  improved  protein function prediction screening in-silico structure based mutagenesis of xylanases from Thermomyces lanuginosus.
Bioinformatics.
Enzymology.
Proteins .
Bioinformatics.
Enzymology.
Protein Science.
SpringerBriefs in Systems Biology