Inherited Cancer Syndromes [electronic resource] : Current Clinical Management /
Ellis, C. Neal.editor.
The advances in our understanding of genetics has exploded since the publication of the first edition of Inherited Cancer Syndromes. We’ve moved from an incomplete understanding of the human genome to the availability of over-the-counter DNA analysis kits. There is simply too much complicated, high-level science for a busy clinician to meaningfully absorb without a filter. Inherited Cancer Syndromes is designed to bridge that gap. With this new edition, the clinical content has been expanded and clarified in order to be more tightly focused on the real-world implications of emerging therapies. The chapter authors are among the leading experts in these topics. Naturally, this book is not meant to be an exhaustive “how to” textbook or procedure-heavy monograph, but a clinically relevant overview of this dynamic and difficult aspect of cancer patient care. “ The chapters on syndromes are divided by type of cancer, and each includes discussions of risk assessment, indications for genetic testing, interpretation of test results, and integration into clinical management of risk estimates and results of genetic testing. The chapter on breast cancer also provides an insightful discussion of surrogate end-point markers. Each syndrome of susceptibility to polyposis and nonpolyposis colon cancer is described, with algorithms as to when genetic testing is indicated. Guidelines for prevention and management follow. … This book provides the knowledge base needed for most physicians to incorporate the principles of inherited susceptibility to cancer and genetic testing properly into their practices. It is highly recommended, since many physicians and health care workers have not been trained in this area, which has become an established part of clinical medicine.” Book Review, New England Journal of Medicine Volume 351:2137-2138 November 11, 2004 Number 20.
Description based upon print version of record.
Inherited Cancer Syndromes; Contents; Contributors; Chapter 1: Obtaining and Using Genetic Information; Introduction; Collecting Family History of Cancer Information; Genetic Counseling; Clinical Scenarios; Scenario 1: Breast Cancer; Take Home Message; Scenario 2: Breast Cancer; Take Home Message; Scenario 3: Breast Cancer; Take Home Message; Scenario 4: Breast Cancer; Take Home Message; Scenario 5: Colorectal Cancer; Take Home Message; Scenario 6: Colorectal Cancer; Take Home Message; Scenario 7: Colon Cancer; Take Home Message; Scenario 8: Colon Cancer; Take Home Message; Conclusions
ReferencesChapter 2: Cancer and Genetic Counseling; Introduction; Background; Genetic Counseling; Referring to a Genetic Counselor; Personal Medical History; Family Medical History; Risk Assessment; Genetic Testing; Clinical Versus Research Genetic Testing; Genetic Test Results; Predictive Genetic Testing; Benefits of Genetic Testing; Limitations of Genetic Testing; Risks Associated with Genetic Testing; Conclusion; References; Chapter 3: An Ethos of Genetic Testing; Overview; Health Care Ethics: Groundwork; Genetic Testing: Adults; Genetic Testing: Children
Genetic Testing: Fetus (Pre-Natal)Genetic Testing: Embryo (Pre-Implantation); Genetic Testing: Commercialization; Summary; References; Chapter 4: Hereditary Breast Cancer Syndromes; Introduction; Hereditary Breast and Ovarian Cancer Syndrome; Susceptible Genes; BRCA1; BRCA2; Identifying Hereditary Risk for Breast Cancer; Family History; Risk Assessment Models; Empirical Models; Probabilistic Models; Genetic Counseling; Genetic Discrimination; BRCA Genetic Testing; Positive Test Result; Negative Test Result; Indeterminate Test Result; Screening and Risk Management
Prophylactic Bilateral MastectomyProphylactic Bilateral Oophorectomy; Chemoprevention; Clinical Characteristics and Management of BRCA1 and BRCA2 Associated Breast Cancer; BRCA1; BRCA2; Histopathology; Surgical Treatment Options; Role of Prophylactic Contralateral Mastectomy; Adjuvant Therapy; Prognosis; Other Hereditary Syndromes Associated with Breast Cancer; Li-Fraumeni Syndrome (P53); Cowden's Disease (PTEN); Peutz-Jeghers Syndrome (STK11/LKB1); Muir-Torre Syndrome (MSH2/MLH1); Ataxia Telangiectasia (ATM); CHEK2; P450 Gene CYP1A1; Glutathione S-Transferases; N-Acetyltransferase
Low-Penetrant Breast Cancer Susceptibility GenesGene Expression Profilling; References; Chapter 5: Gastrointestinal Polyposis Syndromes; Introduction; Familial Adenomatous Polyposis; Extracolonic Manifestations of FAP; Genetic Testing for FAP; Management of FAP; Surgery for FAP; Attenuated Familial Adenomatous Polyposis; Management of AFAP; MYH Associated Polyposis; Hyperplastic Polyposis; Peutz-Jeghers Syndrome; Juvenile Polyposis Syndrome; PTEN Hamartoma Tumor Syndrome; Conclusion; References; Chapter 6: Familial Colorectal Cancer Type X; Introduction
Clinical Evidence for Familial Colorectal Cancer Type X
The advances in our understanding of genetics has exploded since the publication of the first edition of Inherited Cancer Syndromes. We’ve moved from an incomplete understanding of the human genome to the availability of over-the-counter DNA analysis kits. There is simply too much complicated, high-level science for a busy clinician to meaningfully absorb without a filter. Inherited Cancer Syndromes is designed to bridge that gap. With this new edition, the clinical content has been expanded and clarified in order to be more tightly focused on the real-world implications of emerging therapies. The chapter authors are among the leading experts in these topics. Naturally, this book is not meant to be an exhaustive “how to” textbook or procedure-heavy monograph, but a clinically relevant overview of this dynamic and difficult aspect of cancer patient care. “ The chapters on syndromes are divided by type of cancer, and each includes discussions of risk assessment, indications for genetic testing, interpretation of test results, and integration into clinical management of risk estimates and results of genetic testing. The chapter on breast cancer also provides an insightful discussion of surrogate end-point markers. Each syndrome of susceptibility to polyposis and nonpolyposis colon cancer is described, with algorithms as to when genetic testing is indicated. Guidelines for prevention and management follow. … This book provides the knowledge base needed for most physicians to incorporate the principles of inherited susceptibility to cancer and genetic testing properly into their practices. It is highly recommended, since many physicians and health care workers have not been trained in this area, which has become an established part of clinical medicine.” Book Review, New England Journal of Medicine Volume 351:2137-2138 November 11, 2004 Number 20.
Surgery.
Oncology  .
Surgical oncology.
Human genetics.
Cancer research.
General Surgery.
Oncology.
Surgical Oncology.
Human Genetics.
Cancer Research.