RNA Technologies in Cardiovascular Medicine and Research [electronic resource] /
Erdmann, Volker A.editor.
Poller, Wolfgang.editor.
Barciszewski, Jan.editor.
Cardiovascular disease is the number one cause of death worldwide. In 2005 17.5 million people, representing 30% of all global deaths, died of cardiovascular disease. For this reason every effort needs to be made to improve the early diagnosis and treatment procedures for combating this disease. This book - edited by Professors Erdmann and Barciszewski, both internationally recognised experts in the field of RNA molecular biology, and Professor Poller, an internationally respected expert in cardiology - will offer more than an introduction to these fields. More importantly, it will also lead the reader to the newest developments in RNA methods and technologies and show how they are currently employed for the diagnosis and treatment of cardiovascular disease. This book is also a must for all those interested in knowing more about the molecular medicine of tomorrow and how it will be revolutionised by its newest approach - RNA technologies.
Description based upon print version of record.
Includes bibliographical references and index.
MicroRNA -- An Overview of MicroRNA -- MicroRNAs and Their Potential -- miRNAs and Their Emerging Role in Cardiac Hypertrophy -- MicroRNAs and the Control of Heart Pathophysiology -- MicroRNA Systems Biology -- RNA Interference -- Targeting Viral Heart Disease by RNA Interference -- Design of siRNAs and shRNAs for RNA Interference: Possible Clinical Applications -- RNA Interference and MicroRNA Modulation for the Treatment of Cardiac Disorders -- Cardiac Delivery of Nucleic Acids by Transcriptional and Transductional Targeting of Adeno-Associated Viral Vectors -- Ribozymes -- Characterization of Hammerhead Ribozymes Potentially Suitable for the Treatment of Hyper-Proliferative Vascular Diseases -- Applications of Ribozymes and Pyrrole–Imidazole Polyamides for Cardiovascular and Renal Diseases -- Noncoding, Aptamer and Antisense RNAs -- Noncoding RNAs in Human Diseases -- Aptamers and siRNAs in Cardiovascular Disease -- Nucleic Acid Aptamers for Cardiovascular Therapeutics -- NF?B Decoy Oligodeoxynucleotide-Based Therapy in Cardiovascular Diseases -- Antisense Therapy for Restenosis Following Percutaneous Coronary Interventions -- Toxic RNA in Pathogenesis of Human Neuromuscular Disorders.
Cardiovascular disease is the number one cause of death worldwide. In 2005 17.5 million people, representing 30% of all global deaths, died of cardiovascular disease. For this reason every effort needs to be made to improve the early diagnosis and treatment procedures for combating this disease. This book - edited by Professors Erdmann and Barciszewski, both internationally recognised experts in the field of RNA molecular biology, and Professor Poller, an internationally respected expert in cardiology - will offer more than an introduction to these fields. More importantly, it will also lead the reader to the newest developments in RNA methods and technologies and show how they are currently employed for the diagnosis and treatment of cardiovascular disease. This book is also a must for all those interested in knowing more about the molecular medicine of tomorrow and how it will be revolutionised by its newest approach - RNA technologies.
Molecular biology.
Human genetics.
Biochemistry.
Molecular Medicine.
Human Genetics.
Biochemistry, general.