Efflux-Mediated Antimicrobial Resistance in Bacteria [electronic resource] : Mechanisms, Regulation and Clinical Implications /
Li, Xian-Zhi.editor.
Elkins, Christopher A.editor.
Zgurskaya, Helen I.editor.
This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.
Includes bibliographical references and index.
I-Bacterial drug efflux pumps: structures and transport mechanisms -- 1.Structures and transport mechanisms of RND efflux pumps -- 2.Structural and molecular landscape of MFS and MATE efflux pumps -- 3.Small multidrug resistance efflux pumps -- 4.Structures and transport mechanisms of the ABC efflux pumps -- 5.Multidrug efflux in the context of two-membrane cell envelopes -- II-Bacterial drug efflux pumps in antimicrobial resistance: substrates, regulation and clinical significance -- 6.Antimicrobial resistance in bacteria: an overview of mechanisms and role of drug efflux pumps -- 7.Antimicrobial drug efflux pumps in Staphylococcus aureus -- 8.Antimicrobial drug efflux pumps in other Gram-positive bacteria -- 9.Antimicrobial drug efflux pumps in Escherichia coli -- 10.Antimicrobial drug efflux pumps in Salmonella -- 11.Antimicrobial drug efflux pumps in Enterobacter and Klebsiella -- 12.Antimicrobial resistance and drug efflux pumps in Vibrio and Legionella -- 13.Antimicrobial resistance and drug efflux pumps in Acinetobacter -- 14.Antimicrobial drug efflux pumps in Pseudomonas aeruginosa -- 15.Antimicrobial drug efflux pumps in Stenotrophomona maltophilia -- 16.Antimicrobial drug efflux pumps in Burkholderia -- 17.Efflux pumps in Neisseria gonorrhoeae: contributions to antimicrobial resistance and virulence -- 18.Efflux pumps in Campylobacter: key players for antimicrobial resistance and environmental adaption -- 19.Antimicrobial resistance and drug efflux pumps in Helicobacter -- 20.Antimicrobial resistance and drug efflux pumps in Bacteroides -- 21.Efflux pumps in mycobacteria: antimicrobial resistance, physiological functions, and role in pathogenicity -- 22.Antimicrobial drug efflux genes and pumps in bacteria of animal and environmental origin -- 23.Role of plasmid-encoded drug efflux pumps in antimicrobial resistance -- 24.Influence of regulatory RNAs on antimicrobial resistance and efflux mechanisms -- III.Role of drug efflux pumps beyond antimicrobial resistance: natural functions -- 25.The relationship between bacterial multidrug efflux pumps and biofilm formation -- 26.Antimicrobial drug efflux systems as components of bacterial stress responses -- 27.Involvment of antimicrobial drug efflux systems in bacterial fitness and virulence -- IV. Antimicrobial development and efflux pump inhibitors -- 28.Impact of antimicrobial drug efflux pumps on antimicrobial discovery and development -- 29.Antimicrobial drug efflux pump inhibitors -- 30.Multidrug efflux pumps and their inhibitors characterized by computational modeling.
This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.
Drug resistance.
Infectious diseases.
Drug Resistance.
Infectious Diseases.