Emerging Therapeutic Targets in Ovarian Cancer [electronic resource] /
Kaye, Stan.editor.
Brown, Robert.editor.
Gabra, Hani.editor.
Gore, Martin.editor.
Despite rapid advances in understanding the biology of ovarian cancer, progress in treatment has been slow. But the prospects for improvement have never been better. A wide range of novel therapeutic targets now present themselves for clinical evaluation and initial results are certainly encouraging. In this text, all these areas are covered by experts in the field. Each chapter provides up-to-date coverage of clinical information, prefaced by a description of the rational basis for the selection of each target area and consideration of biomarkers that can be used to aid clinical evaluation. The four editors work together within the Ovarian Cancer Action collaborative research programme in London and they bring a wealth of laboratory and clinical expertise to this topic. The text should provide an invaluable source of reference for clinical and laboratory-based researchers working to meet the challenges of ovarian cancer.
Description based upon print version of record.
Preface; Contents; Contributors; 1 Systemic Therapy for Ovarian Cancer, Current Treatment, Recent Advances, and Unmet Needs; 2 Discovery of Novel Targets; 3 Novel Anti-angiogenic Therapies in Ovarian Cancer; 4 Targeting the AKT Pathway in Ovarian Cancer; 5 Inhibition of the Src Oncogene: Therapeutic PotentialINTbreak;  in Ovarian Carcinoma; 6 Tumour-Specific Synthetic Lethality: Targeting BRCA Dysfunction in Ovarian Cancer; 7 Targeting Inflammatory Pathways in Epithelial Ovarian Cancer
8 Epithelial-to-Mesenchymal Transition and Cellular Membrane Receptors in Ovarian Cancer: Moving Forward in the Era of Molecularly Targeted Therapy9 Epigenetic Therapies; 10 Ovarian Cancer Immunology and Immunotherapy; 11 Ovarian Cancer Progenitor/Stem Cells: Therapeutic Potential; 12 Potential for -Folate Receptor-Targeted TreatmentINTbreak;  for Ovarian Cancer; 13 New Insights into Tubulin Binders; Index
Includes bibliographical references and index.
Despite rapid advances in understanding the biology of ovarian cancer, progress in treatment has been slow. But the prospects for improvement have never been better. A wide range of novel therapeutic targets now present themselves for clinical evaluation and initial results are certainly encouraging. In this text, all these areas are covered by experts in the field. Each chapter provides up-to-date coverage of clinical information, prefaced by a description of the rational basis for the selection of each target area and consideration of biomarkers that can be used to aid clinical evaluation. The four editors work together within the Ovarian Cancer Action collaborative research programme in London and they bring a wealth of laboratory and clinical expertise to this topic. The text should provide an invaluable source of reference for clinical and laboratory-based researchers working to meet the challenges of ovarian cancer.
Cancer research.
Pharmacology.
Cancer Research.
Pharmacology/Toxicology.