Histone Deacetylases: the Biology and Clinical Implication [electronic resource] /
Yao, Tso-Pang.editor.
Seto, Edward.editor.
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Description based upon print version of record.
CONTENTS; K-Acetylation and Its Enzymes: Overview and New Developments; The Biology of HDAC in Cancer: The Nuclearand Epigenetic Components; Deacetylation of Nonhistone Proteins by HDACsand the Implications in Cancer; The Biology and Therapeutic Implications of HDACs in the Heart; HDACs in Skeletal Muscle Remodeling and Neuromuscular Disease; Rationale for HDAC Inhibitor Therapy in Autoimmunityand Transplantation; The Role of Mammalian Sirtuins in the Regulation of Metabolism,Aging, and Longevity; Mitochondrial Sirtuins in the Regulation of Mitochondrial Activityand Metabolic Adaptation
Characterization of Nuclear Sirtuins: Molecular Mechanismsand Physiological RelevanceStructural Biology of Human Metal-DependentHistone Deacetylases; Sirtuin Modulators; Index
Includes bibliographical references and index.
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Pharmacology.
Medicine.
Posttranslational modification.
Proteins .
Laboratory medicine.
Medical genetics.
Pharmacology/Toxicology.
Biomedicine, general.
Posttranslational Modification.
Protein Science.
Laboratory Medicine.
Gene Function.
Handbook of experimental pharmacology