Nutraceuticals and Cancer [electronic resource] /
Sarkar, Fazlul H.editor.
This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
Description based upon print version of record.
Preface; Contents; Contributors; 1 Global Overview of the Role of Nutraceuticals in Cancer; 1.1 Introduction; 1.2 Nutraceuticals and Bioactive Dietary Components; 1.3 Historical Perspectives; 1.4 Current Research and Future Directions; 1.5 Conclusion and Implications; References; 2 Cancer Stem Cells: Novel Target Using Dietary Components for Prevention and Treatment; 2.1 Introduction; 2.2 Cancer Stem Cells; 2.3 Stem Cells Signaling Pathways; 2.3.1 Hedegehog; 2.3.2 Wnt/ -Catenin; 2.3.3 Notch; 2.4 Cancer Stem Cell Markers; 2.4.1 CD133; 2.4.2 CD44; 2.4.3 Lgr5
2.4.4 Doublecortin Calmodulin Like Kinase-12.4.5 Musashi-1; 2.4.6 Aldehyde Dehydrogenase; 2.5 Diet and Cancer Stem Cells; 2.5.1 EGCG; 2.5.2 Vitamin D3; 2.5.3 Curcumin; 2.5.4 Sulforaphane; 2.5.5 Genistein; 2.5.6 Resveratrol; 2.5.7 Lycopene; 2.6 Drug Resistance and Cancer Stem Cells; 2.7 Concluding Remarks and Future Directions; References; 3 Polyphenols as Receptor Tyrosine Kinase Inhibitors and Anti-cancer Agents; 3.1 Introduction; 3.2 Flavonoid Family of Polyphenols; 3.2.1 Flavanols -- Tea Catechins; 3.2.1.1 MET; 3.2.1.2 EGFR Family; 3.2.1.3 VEGFR; 3.2.1.4 IGF-1R
3.2.2 Flavones: Apigenin and Luteolin3.2.3 Flavonols: Quercetin and Kaempferol; 3.2.4 Flavanones: Taxifolin; 3.2.5 Isoflavones: Genistein; 3.3 Non-flavonoid Family of Polyphenols; 3.3.1 Curcumin; 3.3.2 Resveratrol; 3.3.3 Ellagic Acid; 3.4 Are There Common Mechanisms of Action?; 3.5 Clinical Relevance and Future Directions; 3.5.1 Evidence of Clinical Impact of Polyphenols; 3.5.1.1 Bioavailability; 3.5.1.2 Clinical Trials; 3.5.2 More Effective Use of Polyphenols; 3.5.2.1 Nanoparticles to Deliver Polyphenols; 3.5.2.2 Combination Therapy; 3.5.3 The Long Road to Clinical Use; References
4 Role of Nutraceuticals on Nrf2 and Its Implication in Cancer Prevention4.1 Introduction; 4.1.1 Nutraceuticals; 4.1.2 Nrf2, Phase II Detoxifying/Antioxidant Enzymes, Lifestyles and Cancer Prevention; 4.2 Different Nutraceuticals, Cancer and Phase II Detoxifying/Antioxidant Genes Regulated by Nrf2; 4.2.1 Isothiocyanates: Sulforaphane (SFN) and Phenethyl Isothiocyanate (PEITC); 4.2.2 Polyphenols: Curcumin and Curcmin Analogues; 4.3 Nrf2-Mediated Signaling: Antioxidant/Anti-inflammatory; 4.3.1 In Vitro Studies Using Nrf2 KO Macrophages; 4.3.2 In Vivo Studies Using Nrf2 KO Mice
4.4 Nrf2 in Various Cancers and Chemoprevention by Nutraceuticals4.4.1 Nutraceuticals and Chemoprevention; 4.4.2 Significant Role of Nrf2 in Chemoprevention; 4.4.2.1 Enhanced Susceptibility to Carcinogenesis in Nrf2 KO Mice; 4.4.2.2 Epigenetic Down-Regulation of Nrf2 in Aging TRAMP Mice Prostate Tumors Correlating to Human Prostate Cancer; 4.5 Conclusions; References; 5 Current Status and Future Prospects of Nutraceuticals in Prostate Cancer; 5.1 Introduction; 5.2 Carotenoids; 5.3 Vitamins; 5.4 Minerals; 5.5 Flavonoids; 5.6 Indoles; 5.7 Isothiocyanates; 5.8 Phenolic Acids
5.9 Organosulfur Compounds
Includes bibliographical references and index.
This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
Medicine.
Cancer research.
Nutrition   .
Biomedicine, general.
Cancer Research.
Nutrition.