Pancreatic Stem Cells [electronic resource] /
Domínguez-Bendala, Juan.author.
The aim of Pancreatic Stem Cells is to provide a broad overview of an intriguing model of organogenesis (the development of the pancreas) from the perspective of stem cell research. The tangible prospect of devising effective cell therapies for type I diabetes –a disease thus far considered incurable– has stoked a widespread interest in harnessing our knowledge on the basic biology behind the development of this organ. This text is conceived as an all-encompassing guide to explore the many aspects of "regenerative therapies" for the endocrine pancreas, from adult and embryonic stem cells to endogenous regeneration and transdifferentiation. All these themes are built upon an up-to-date discussion on pancreatic ontogeny, which provides a solid background for both basic scientists and health professionals.
Description based upon print version of record.
152033_1_En_FM1_Chapter.pdf; 152033_1_En_1_Chapter.pdf; The Pancreas; 1 Introduction; 2 The Ductal System; 3 Vasculature; 4 Innervation; 5 Exocrine Pancreas; 6 Endocrine Pancreas; 7 Glucose Metabolism; 152033_1_En_2_Chapter.pdf; Pancreatic Development; 1 Introduction; 2 Generation of Endoderm/Gut Epithelium; 3 Pancreatic Differentiation; Pdx1; 4 Ductal and Exocrine Specification; 5 Endocrine Specification; Ngn3; Isl1; 6 Beta Cell Differentiation; Arx; 7 The Secondary Transition; Prox1; 8 Do Physical Factors Play a Role in Pancreatic Development?
3.1 Do New Beta Cells Arise from the Duct/Acinar Tissue?3.2 Do New Beta Cells Arise from the Islet?; 3.3 Do New Islets Arise from the Bone Marrow?; 4 Molecular Mechanisms of Islet Regeneration; 4.1 Reversible Epithelial-to-Mesenchymal Transition; 4.2 Self-Duplication; 4.3 Re-ignition of the Embryonic Developmental Program; 152033_1_En_4_Chapter.pdf; Stem Cell Differentiation: General Approaches; 1 Introduction; 1.1 In Vitro; 1.1.1 Chemical Strategies; 1.1.2 Genetic Manipulation; 1.1.3 Protein Transduction; 1.1.4 Microenvironment; 1.2 In Vivo; 152033_1_En_5_Chapter.pdf
Embryonic Stem Cells and Pancreatic Differentiation1 Introduction; 2 Mouse ES Cell Experiments; 2.1 Signal-Driven Approaches; 2.2 Genetic Manipulation; 3 Human ES Cell Differentiation; 3.1 Signal-Driven Approaches; 3.2 Genetic Manipulation; 3.3 Protein Transduction; 152033_1_En_6_Chapter.pdf; Adult Stem Cells and Pancreatic Differentiation; 1 Introduction; 2 Mesenchymal Stem Cells; 2.1 Introduction; 2.2 Signal-Driven Approaches; 2.3 Genetic Manipulation; 2.4 Protein Transduction; 2.5 In Vivo Transplantation of Undifferentiated MSCs; 3 Other Stem Cells
3.1 Hematopoietic Bone Marrow and Cord Blood Stem Cells152033_1_En_7_Chapter.pdf; Transdifferentiation; 1 Introduction; 2 Directed Liver Transdifferentiation; 152033_1_En_8_Chapter.pdf; Remaining Challenges and Clinical Perspectives; 1 Introduction; 2 Diabetes and Islet Transplantation; 3 Limitations of Islet Transplantation: Engraftment and Long-Term Function; 4 Limitations of Islet Transplantation: Immunosuppression and Tolerance; 4.1 General Considerations About Islet Rejection; 4.2 Immunology of Stem Cells; 5 Conclusions; 152033_1_En_References.pdf; Anchor 1; 152033_1_En_IDX.pdf
Includes bibliographial references (p. [111]-150) and index.
The aim of Pancreatic Stem Cells is to provide a broad overview of an intriguing model of organogenesis (the development of the pancreas) from the perspective of stem cell research. The tangible prospect of devising effective cell therapies for type I diabetes –a disease thus far considered incurable– has stoked a widespread interest in harnessing our knowledge on the basic biology behind the development of this organ. This text is conceived as an all-encompassing guide to explore the many aspects of "regenerative therapies" for the endocrine pancreas, from adult and embryonic stem cells to endogenous regeneration and transdifferentiation. All these themes are built upon an up-to-date discussion on pancreatic ontogeny, which provides a solid background for both basic scientists and health professionals.
Cell biology.
Developmental biology.
Diabetes.
Endocrinology .
Cell Biology.
Developmental Biology.
Diabetes.
Endocrinology.