Early Brain Injury or Cerebral Vasospasm [electronic resource] : Vol 1: Pathophysiology /
International Conference on Cerebral Vasospasm(10th :2009 :Chongqing, China)
FENG, HUA.editor.
Mao, Ying.editor.
Zhang, John H.editor.
More than 40 articles provide an extensive coverage of advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries and cerebral vasospasm. Early brain injury, the new frontier of subarachnoid hemorrhage research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hemorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.
A Clinical Review of Cerebral Vasospasm and Delayed Ischaemia Following Aneurysm Rupture; Introduction; Incidence of Vasospasm; Angiographic Spasm; Delayed Ischaemic Deficits; Outcome; Conclusion; References; New Regulatory, Signaling Pathways, and Sources of Nitric Oxide; New Regulatory, Signaling Pathways; NOS Synthesis and Regulation; eNOS Single Nucleotide Polymorphism (SNP); eNOS Phosphorylation; NO Synthesis; Asymmetric Dimethylarginine (ADMA); Arginase; Substrate and Coenzyme Deficiency; Erythropoietin (EPO); Soluble Guanylyl Cyclase (sGC) and cGMP Regulation
New Sources of Nitric Oxide Biological ActivityNitrite an On-Demand NO Donor; Nitrate as a Source of NO; Conclusion; References; Advances in Experimental Subarachnoid Hemorrhage; Introduction; Underlying Pathophysiological Pathways and Treatment Strategies Targeting CVS and EBI in SAH; CVS and Nitric Oxide Synthase (NOS)-Nitric Oxide (NO) Pathway; CVS and Endothelin Pathway; CVS and Hypoxia Inducible Factor-1 (HIF-1); CVS and Inflammation; CVS/EBI and Oxidative Stress; CVS/EBI and Apoptosis; Statin and CVS/EBI; Thrombin and CVS/EBI; Conclusion; References
Advances in Treatment of Cerebral Vasospasm: an UpdateIntroduction; Calcium Antagonists; Statins; Magnesium Sulphate; Fasudil Hydrochloride; Conclusion; References; Roles of Signal Transduction Mechanisms in Cerebral Vasospasm Following Subarachnoid Hemorrhage: Overview; Introduction; Overview; Protein Kinase C (PKC); Myosin Light Chain Phosphorylation; Rho-Kinase and Rho A; Protein Tyrosine Kinase (PTK); Phenotypic Change of the Vascular Smooth Muscle Cells; Mitogen-Activated Protein (MAP)/MAP Kinase (MAPK); Conclusion; References; Hypoperfusion in the Acute Phase of Subarachnoid Hemorrhage
IntroductionMethods; Results; Discussion; Conclusion; References; Association of APOE Polymorphism with the Change of Brain Function in the Early Stage of Aneurysmal Subarachnoid Hemorrhage; Introduction; Materials and Methods; Patients; APOE Genotyping; EEG Detection and Interpretation; Statistical Analysis; Results; Conclusion; References; Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage; Introduction; Pathophysiology of Early Brain Injury; Intrinsic Mechanisms of Apoptosis and SAH; Caspase-Dependent Pathway; Caspase-Independent Pathway
Oxidative Stress and Early Brain InjuryDNA Damage; Extrinsic Pathway of Apoptosis; Treatments; Conclusion; References; Early Micro Vascular Changes After Subarachnoid Hemorrhage; Introduction; Cerebral Microvasculature;  Anatomical Architecture; Microvascular Injury After SAH; Endothelium; Basal Lamina Degradation; Platelet Aggregation; Conclusion; References; Immunological Response in Early Brain Injury After SAH; Introduction; Cytokine Activity After SAH; Interleukin-1beta; Relationship Between IL-1beta and Matrix Metalloproteinase (MMP)
Relationship Between IL-1beta and Mitogen Activated Protein Kinase (MAPK) Signaling Pathways
Based on the 10th International Conference on Cerebral Vasospasm, held on October 9-11, 2009, in Chongqing, China.
Includes bibliographical references and indexes.
More than 40 articles provide an extensive coverage of advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries and cerebral vasospasm. Early brain injury, the new frontier of subarachnoid hemorrhage research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hemorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.
Neurosurgery.
Neurosurgery.
Acta neurochirurgica