Cadmium: From Toxicity to Essentiality [electronic resource] /
Sigel, Astrid.editor.
Sigel, Helmut.editor.
Sigel, Roland KO.editor.
Cadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.
Description based upon print version of record.
Cadmium: From Toxicity to Essentiality; Historical Development and Perspectives of the Series: Metal Ions in Life Sciences*; Metal Ions in Life Sciences; Preface to Volume 11; Cadmium: From Toxicity to Essentiality; Contents; Contributors to Volume 11; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; Chapter 1: The Bioinorganic Chemistry of Cadmium in the Context of Its Toxicity; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction
1 Introduction: Importance of Cadmium Accumulation in Plants1 Introduction; 1 Introduction; 1 Introduction; 2 Cadmium Coordination Chemistry of Biological Relevance; 2.1 Cadmium Complexes, Stabilities, and Properties; 2 Geochemistry of Cadmium; 2.1 Chemical Properties; 2 Biomarkers of Exposure; 2.1 Overview; 2 Cadmium Toxicity in Cells; 3 Detection of Intracellular Cadmium; 2 General Considerations and Basic Principles; 3 113Cd NMR Chemical Shifts from 113Cd-Substituted Metalloproteins; 2.1 Adenine; 2.2 N-Substituted Purines with Non-coordinating Pendant Arms
2 Complexes of Amino Acids and Derivatives2.1 General Characteristics of Cadmium(II) Complexes of Amino Acids; 1.1 Cadmium Accumulation in Indicator and Excluder Plants; 1.2 Active Cadmium Hyperaccumulation; 2 Sources and Exposures; 2.1 Occupational Sources and Exposures; 2 Epidemiology and Animal Carcinogenicity; 2.1 Carcinogenicity in Humans; 2 Cadmium Distribution in the Ocean; 2.1 Vertical Profiles; 2.2 Cadmium Protein Complexes; 2.2 Abundance in the Continental Crust; 2.2 Pre-analytic Phase; 3.1 Overview of Cadmium Detection
4 Specific Highlights of Studies on Alkaline Phosphatase, Calcium Binding Proteins, and Metallothioneins2.3 N-Substituted Purines with Potential Chelating Pendant Arms; 2.2 Complexes of Amino Acids with Non-coordinating Side Chains; 2 Ecological Role of Cadmium Hyperaccumulation; 2.2 Non-Occupational Sources and Exposures; 2.2 Carcinogenicity in Experimental Animals; 2.2 Isotope Composition; 2.3 Cadmium Interactions with Other Biomolecules; 3 Cadmium Biochemistry; 3 Mobilization of Cadmium; 3.1 Natural Sources; 2.3 Analytical Methods for the Determination of Cadmium
2.3.1 Inductively Coupled Plasma Mass Spectrometry3.2 Principles of the Development of Fluorescence Probes for Metal Ions; 3.3 Fluorescence Imaging of Cadmium with Calcium or Zinc Fluorescence Probes; 4.1 113Cd NMR and Alkaline Phosphatase; 4.2 113Cd NMR and Calcium Binding Proteins; 2.4 6-Mercaptopurine; 2.5 Oxopurines; 2.3 Complexes of Amino Acids with Coordinating Side Chains; 2.3.1 Complexes of Amino Acids with O-Donor Side Chains; 3 Mechanisms of Cadmium Hyperaccumulation; 3.1 Compartmentation of Cadmium in Tissues, Cells, and Organelles; 3 Entry Pathways, Transport, and Trafficking
3.1 Entry Pathways
Includes bibliographical references and index.
Cadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.
Proteins .
Medicine.
Analytical chemistry.
Inorganic chemistry.
Protein Science.
Biomedicine, general.
Analytical Chemistry.
Inorganic Chemistry.
Science, Humanities and Social Sciences, multidisciplinary.