Endothelial Signaling in Development and Disease [electronic resource] /
Schmidt, Mirko HH.editor.
Liebner, Stefan.editor.
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies.  The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research.   Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.
Description based upon print version of record.
Foreword; Contents; About the Editors; Contributors; Part I; Development and Differentiation of the Vascular System; Chapter-1; VEGF and Notch Signaling in angiogenesis ; 1.1 Overview of Vascular Morphogenesis; 1.1.1 Sprouting; 1.1.2 Intussusceptive Angiogenesis; 1.1.3 Shear Stress; 1.1.4 EPCs; 1.1.5 Embryoid Bodies; 1.2 Signaling Pathways Governing Blood Vessel Formation; 1.2.1 Molecular Structure of VEGFs and VEGFRs; 1.2.2 Signaling for Angiogenesis: VEGF and VEGFR2; 1.2.3 Angiogenic Modifiers: VEGFR1, VEGF-B and PIGF; 1.2.4 Fibroblast Growth Factor (FGF); 1.2.5 Ang/Tie Signaling
1.2.6 Hypoxia-inducible Factor (HIF)1.2.7 NO Signaling; 1.2.8 The Notch Signaling Pathway; 1.3 Blood-vessel Formation at the Molecular and Cellular Level; 1.3.1 Notch in Angiogenesis; 1.3.2 Negative Regulators of Notch Signaling in ECs; 1.3.3 Notch and Cellular Signaling in ECs; 1.3.4 Arterial Specification: Notch Meets Wnt; 1.4 VEGF and Notch: the Interplay; 1.4.1 The Physiological Interplay: EC Sprouting; 1.4.2 Pathological Interplay: Tumor Angiogenesis; 1.4.3 Targeting Tumor Angiogenesis; 1.5 Concluding Remarks; References; Chapter-2
2.1  Zebrafish Vasculogenesis and Arteriovenous Specification 2.2  Molecular Cues During Vasculogenesis ; 2.3  Molecular Regulation of Arterial-Venous Specification ; 2.3.1  EphrinB2/Eph Receptor B4 ; 2.3.2  Vascular Endothelial Growth Factor and Sonic Hedgehog ; 2.3.3  Notch and Hey2 ; 2.3.4  SoxF Family Members ; 2.3.5  Fox and ETS ; 2.4  Summary ; References; Chapter-3; Pericytes in Vascular Development and Function; 3.1 Introduction; 3.2 Cell Biology of Pericytes; 3.2.1 Cell Morphology; 3.2.2 Heterogeneity of Pericytes; 3.2.3 Cell Adhesion to Endothelial Cells
3.2.4 Interaction with the Extracellular Matrix3.3 Cell Development; 3.3.1 Cell Lineage; 3.3.2 Differentiation; 3.3.3 Vascular Recruitment; Signaling Axis: PDGF-B/PDGFRβ; Transforming Growth Factor-β; Other Pathways; 3.4 Regulation of Vascular Function; 3.4.1 Regulation of Angiogenesis; 3.4.2 Regulation of Blood Flow; 3.4.3 Regulation of Leukocyte Trafficking; 3.4.4 Regulation of Vascular Permeability; 3.4.5 Regulation of Injury/Disease; 3.4.6 Regulation of Tissue-Specific Properties; Hepatic Stellate Cells; Thymus Pericytes; Renal Pericytes; 3.5 Summary; References; Chapter-4
Fibroblast Growth Factor Signaling in Vascular Development4.1 Overview of the Fibroblast Growth Factor (FGF) Family; 4.2 The Family of FGF Receptors (FGFRs); 4.3 Alternative Splicing Yields Structurally and Functionally Diverse FGFRs; 4.4 Three Major Pathways are Involved in Canonical FGF/FGFR Signal Transduction; 4.5 Negative Regulation of FGFR1 Signaling; 4.6 FGF Co-Receptors and Extracellular Matrix Components Contribute to FGF-Dependent Signal Transduction; 4.7 Current Knowledge About FGFs and Their Receptors in Vascular Development is Limited
4.8 The Vascular System is Built Through Vasculogenesis and Angiogenesis
Includes bibliographical references at the end of each chapters and index.
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies.  The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research.   Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.
Human physiology.
Cell physiology.
Hematology.
Angiology.
Systems biology.
Human Physiology.
Cell Physiology.
Hematology.
Angiology.
Systems Biology.