Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors [electronic resource] /
Brouns, Inge.author.
Pintelon, Isabel.author.
Timmermans, Jean-Pierre.author.
Adriaensen, Dirk.author.
Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of ‘sensory airway receptors’ is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties.
Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors; Contents; Chapter 1: Sensory Nerve Terminals in Intrapulmonary Airways and Lungs; 1.3 Studying Airway Afferents; Chapter 2: Electrophysiologically Identified Airway Receptors: Main Characteristics; 2.3 C-Fibre Receptors; Chapter 3: Morphology and Location of Electrophysiologically Identified Sensory Airway Receptors; Chapter 4: The Neurochemical Coding of Airway Afferents; 4.1 Antibody Markers for Potential Pulmonary Mechanosensory Nerve Terminals
Chapter 5: Morphologically Identified Sensory Receptor End-Organs in the Airways, Lungs and Visceral Pleura5.3.2 Functional Implications; Chapter 6: In Situ Functional Imaging of Sensory Receptors in Lung Models; 6.1 Selective Visualisation of Sensory Lung Receptors with Styryl Pyridinium Dyes; 6.2.2 Control Stimuli for Activation of the Different Epithelial Cell Types in the Ex Vivo Lung Slice Model; Chapter 7: Concluding Remarks and Future Prospects; Subject Index
"With 24 figures."
Includes bibliographical references and index.
Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of ‘sensory airway receptors’ is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties.
Human physiology.
Neurochemistry.
Human Physiology.
Neurochemistry.
Advances in anatomy, embryology and cell biology