History of Vaccine Development [electronic resource] /
Plotkin, Stanley A.editor.
The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases.  However, no vaccine development has been easy and there is an interesting story attached to each.  The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries.   The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine.  .
Description based upon print version of record.
History of Vaccine Development; Contents; Contributors; Introduction; "Variolation" and Vaccination in Late Imperial China, Ca 1570-1911; The Development of Variolation in China; Variolation Practiced by the Manchu Imperial Family; Introduction of Jennerian Vaccination; Acceptance of Jennerain Vaccination; References; Edward Jenner's Role in the Introduction of Smallpox Vaccine; Introduction; Early Observations; Jenner's Vaccinations; True and Spurious Cowpox; Jenner in Perspective; Conclusion; References; Edward Jenner, Benefactor to Mankind; References
Smallpox Eradication: The Vindication of Jenner's ProphesyThe First WHO Global Smallpox Eradication Campaign; The Intensified Smallpox Eradication Programme; Vaccination in the Intensified Smallpox Eradication Programme; New Methods of Vaccination; Surveillance and Containment; References; Pasteur and the Birth of Vaccines Made in the Laboratory; Introduction; Studies on Anthrax; Pasteur and the Chicken Cholera; Pasteur and Toussaint and Their Competition for an Anthrax Vaccine; Pasteur and Thuillier and the Swine Erysipelas; Pasteur and the Treatment of Rabies
The Diffusion of the First Generation of Vaccines and Why!Conclusion; References; Antituberculosis BCG Vaccine: Lessons from the Past; Previous Knowledge; Discovery of BCG; Antituberculosis Immunity; BCG Vaccination; BCG Strain Diversity; BCG Vaccine Manufacture; BCG Efficacy; References; A History of Toxoids; Introduction; Discovery of Diphtheria and Tetanus Toxins, Toxoids and Antitoxins; Preparation of Diphtheria Toxin; Preparation of Tetanus Toxin; Preparation of Purified Toxoids; The Use of Adjuvants; References
Vaccination Against Typhoid Fever: A Century of Research. End of the Beginning or Beginning of the End?Introduction; Historical Overview of Typhoid Fever; Introduction of Typhoid Vaccination: A Wright or R Pfeiffer?; Typhoid Fever Morbidity and Mortality in Relation to Vaccination: A Debate; At Last a Response; Toward a Significant Improvement: Vi Polysaccharide Vaccines; Live Attenuated Mutants of S. typhi Given Orally: An Alternative Option?; Is It the End, the Beginning of End or the End of the Beginning?; References
The History of Pertussis Vaccination: From Whole-Cell to Subunit VaccinesThe Efficacy of Whole-Cell Vaccines; The Adverse Effects of Whole-Cell Vaccines; Development of Subunit Vaccines; The Efficacy of Subunit and Acellular Pertussis Vaccines; The Adverse Effects of Subunit and Acellular Pertussis Vaccines; Laboratory Correlates with Protection for Subunit Vaccines; References; Bacterial Polysaccharide Vaccines; References; Polysaccharide-Protein Conjugate Vaccines*; Historic Background; Primary Pathogens; Prevention of Hemophilus influenzae Type b (Hib) Meningitis; Historic Considerations
Capsular Polysaccharides of Hemophilus influenzae
Includes bibliographical references and index.
The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases.  However, no vaccine development has been easy and there is an interesting story attached to each.  The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries.   The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine.  .
Immunology.
Microbiology.
Medicine.
Virology.
Pharmaceutical technology.
Immunology.
Microbiology.
Medicine/Public Health, general.
Virology.
Pharmaceutical Sciences/Technology.