Henipavirus [electronic resource] : Ecology, Molecular Virology, and Pathogenesis /
Lee, Benhur.editor.
Rota, Paul A.editor.
Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested.    This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.  .
Description based upon print version of record.
Henipavirus; Preface; Contents; Contributors; 218 Introduction: Nipah Virus---Discovery and Origin; Abstract; 1...Introduction; 2...Discovery of Nipah Virus; 2.1 Early Period and Suspicions of Japanese Encephalitis; 2.2 Clinical Samples and Virus Isolation; 2.3 Early Evidence for the Presence of a Novel Virus; 2.4 Identification of a Novel Agent; 3...Origin of Nipah Virus; 3.1 Switching Focus From Laboratory to Field; 3.2 New Approach for Sample Collection; 4...Challenges Encountered; References; 214 Ecological Aspects of Hendra Virus; Abstract; 1...Introduction; 2...Hendra Virus Incidents 1994--2010
2.1 Horses and Humans2.2 Ecological Studies; 3...An Unprecedented Hendra Year 2011; 3.1 More Incidents, More Locations; 3.2 What Was Different?; 3.3 An Effective Vaccine?; 4...Fruit Bats and Hendra Virus; 5...Epilogue; References; 207 Epidemiology of Henipavirus Disease in Humans; Abstract; 1...Hendra Outbreaks; 2...Nipah Virus Outbreaks; 2.1 Malaysia/Singapore; 2.2 NiV Epidemiology Bangladesh/India; 3...NiV Transmission Through Date Palm Sap; 4...NiV Transmission from Domestic Animals; 5...NiV Person-To-Person Transmission; 6...Other Plausible Pathways of NiV Transmission
7...Open Questions in the Epidemiology of Henipaviruses8...Conclusion; Acknowledgments; References; 211 Molecular Virology of the Henipaviruses; Abstract; 1...Nipah and Hendra Viruses; 1.1 Classification; 1.2 Genome Organization; 1.3 Replication Cycle; 1.4 Morphology; 1.5 Viral Proteins; 1.5.1 G Glycoprotein; 1.5.2 F Glycoprotein; 1.5.3 M Protein; 1.5.4 N Protein; 1.5.5 L Protein; 1.5.6 P Gene Protein Products; 2...Genetics and Reverse Genetics; 3...Molecular Diversity; 3.1 NiV; 3.2 HeV; 4...Conclusion; Disclaimer; References; 222 Henipavirus Receptor Usage and Tropism; Abstract; 1...The Receptors
1.1 The Molecular Biology of Ephrin-B21.2 Surface Expression and Regulation; 1.3 Distribution; 1.3.1 Ephrin-B2; 1.3.2 Ephrin-B3; 1.4 Receptor and Host Range; 1.5 Ephrins and Henipavirus Cellular Tropism In Vitro; 2...Glycoprotein-Receptor Interaction; 2.1 The Attachment Glycoprotein G; 2.2 Henipavirus-G-receptor Interaction; 2.3 The Internalization of Viral Particles; 3...Receptor Usage and Henipavirus Pathogenesis; 3.1 Pathology and Symptoms; 3.2 Ephrin-B2/B3 and NiV Pathogenesis; 3.3 Alternative Tropism and Trans-Infection; 4...Perspectives; References
200 Henipavirus Membrane Fusion and Viral EntryAbstract; 1...Introduction; 2...The Role(s) of Henipavirus G in Membrane Fusion; 2.1 Paramyxovirus Attachment Proteins; 2.2 Henipavirus G and Membrane Fusion; 3...F/G Interactions; 4...The Role of Henipavirus F in Membrane Fusion; 4.1 Paramyxovirus Fusion Proteins; 4.2 Henipavirus F and Membrane Fusion; 5...Epilogue; References; 205 Clinical and Pathological Manifestations of Human Henipavirus Infection; Abstract; 1...Introduction; 2...Clinical Aspects and Sequelae of Henipavirus Infection; 3...Pathology of Acute Henipavirus Infection in Humans
4...Pathology of Relapsing Henipavirus Encephalitis
Includes bibliographical references and index.
Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested.    This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.  .
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Current topics in microbiology and immunology