NF-κB-Related Genetic Diseases [electronic resource] /
Courtois, Gilles.author.
Pescatore, Alessandra.author.
Gautheron, Jérémie.author.
Fusco, Francesca.author.
Ursini, Matilde Valeria.author.
Senegas, Anna.author.
This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.
Description based upon print version of record.
Includes bibliographical references at the end of each chapters.
1) The NF-kB signaling pathways: players and Functions -- 2) Genetic Diseases Affecting the Canonical Pathway of NF-kB Activation -- 3) Genetic Diseases Affecting hte Non-Camonical Pathway of NF-kB Activation -- 4) Genetic Diseases Affecting Ubiquitination Processes in NF-kB Signaling -- 5)Lessons Learned from Studying NF-kB Related Genetic Diseases.
This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.
Molecular biology.
Human genetics.
Medical biochemistry.
Molecular Medicine.
Human Genetics.
Medical Biochemistry.