Autoimmune Diseases of the Skin [electronic resource] : Pathogenesis, Diagnosis, Management /
Hertl, Michael.editor.
Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.
Description based upon print version of record.
""Title Page""; ""Copyright Page""; ""Foreword""; ""Prefaces""; ""Preface to the Third Edition""; ""Preface to the Second Edition""; ""Preface to the First Edition""; ""Table of Contents""; ""List of Contributors""; ""1 Pathogenesis of Autoimmune Diseases""; ""Autoimmunity and autoimmune disease""; ""T and B cells""; ""Thymic maturation and selection of T cells""; ""Tolerance of self-reactive T and B cells""; ""Central tolerance and peripheral tolerance""; ""Mechanisms of peripheral tolerance""; ""Activation and differentiation of T cells""; ""Activation of self-reactive T and B cells""
""Breaking T and B cell tolerance""""Autoimmune disease""; ""T cells""; ""B cells and immunoglobulins""; ""Tissue damage, Th1, and Th17 cells""; ""Th2 T cells and T-B cell interactions (Fig. 2)""; ""Therapeutic induction of functional tolerance""; ""References""; ""2 Autoantibody Detection Using Indirect Immunofluorescence on HEp-2 Cells""; ""Introduction""; ""Reagents and Test Preparation""; ""HEp-2 Cells""; ""Workplace""; ""Assay Procedure""; ""Processing of Samples""; ""Serum Dilution""; ""Controls""; ""Microscopy""; ""Evaluation and Interpretation""; ""Summary""; ""References""
""3 Autoimmune Bullous Skin Disorders 3.1 Pemphigus""""Introduction""; ""Pathogenesis""; ""Autoantibody profile and clinical appearance""; ""Clinical presentation""; ""Differential diagnosis""; ""Pemphigus foliaceus""; ""Paraneoplastic pemphigus""; ""Drug-induced pemphigus""; ""IgA pemphigus""; ""Diagnosis""; ""Histological analysis""; ""Direct and indirect immunofluorescence studies""; ""Immunoserological diagnosis with autoantigens""; ""Parameters for assessment of clinical course""; ""Therapy""; ""Summary""; ""References""
""3 Autoimmune Bullous Skin Disorders 3.2 Bullous Pemphigoid: Clinical Features, Diagnostic Markers, and Immunopathogenic Mechanisms""""Introduction""; ""Clinical features""; ""Presentation and clinical Setting""; ""Diagnosis""; ""Differential diagnosis""; ""Therapy and Prognosis""; ""Disease activity and relapse markers""; ""Challenging situations""; ""Pathogenesis""; ""BP180 and BP230 are components of hemidesmosomes, junctional adhesion complexes""; ""BP, an example of organ-specific autoimmune disease""; ""Humoral immune response""; ""Cellular immune response and inflammatory cascade""
""Pathogenic mechanism of blister formation""""Unresolved issues and perspectives""; ""Summary""; ""References""; ""3 Autoimmune Bullous Skin Disorders 3.3 Dermatitis Herpetiformis Duhring""; ""Introduction""; ""Clinical Appearance / Classification""; ""Diagnosis""; ""Direct Immunofluorescence Microscopy""; ""Histopathology""; ""Serological Findings""; ""Therapy""; ""Summary""; ""References""; ""3 Autoimmune Bullous Skin Disorders 3.4 Epidermolysis Bullosa Acquisita""; ""Introduction""; ""Etiology and Pathogenesis""; ""Etiology and Epidemiology""; ""Pathogenesis""; ""Clinical Manifestations""
""Classical EBA""
Includes bibliographical references and index.
Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.
Dermatology.
Rheumatology.
Immunology.
Pediatrics.
Otorhinolaryngology.
Ophthalmology.
Dermatology.
Rheumatology.
Immunology.
Pediatrics.
Otorhinolaryngology.
Ophthalmology.