Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium [electronic resource] /
Toman, Rudolf.editor.
Heinzen, Robert A.editor.
Samuel, James E.editor.
Mege, Jean-Louis.editor.
Over 20 years have elapsed since publication of the seminal two volume series entitled Q Fever: The Biology of Coxiella burnetii (edited by J. C. Williams and H. A. Thompson) and Q fever: The Disease (edited by T. J. Marrie) that described the current state of Coxiella burnetii research. The ensuing years have brought the post-genomic era and accompanying technologies that have catalyzed major advances in the field, including milestones discoveries of genetic transformation and host cell-free growth of this former obligate intracellular bacterium. Understanding how the bacterium resists the degradative functions of vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen.   The book covers the current state-of-the-art knowledge in the selected fields of C. burnetii/Q fever research. Coxiella has matured from a niche organism, investigated by a handful of laboratories worldwide, to a model system to study macrophage parasitism, developmental biology, host-pathogen interactions, and immune evasion/modulation.
Description based upon print version of record.
Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium; Preface; Contents; Chapter 1: History and Prospects of Coxiella burnetii Research; 1.1 History; 1.2 The Bacterium; 1.3 The Disease; 1.4 Clinical/Laboratory Diagnosis and Treatment; 1.5 Epidemiology; 1.6 Vaccines; 1.7 Prospective; References; Chapter 2: Phylogenetic Diversity, Virulence and Comparative Genomics; 2.1 Phylogenetic Diversity; 2.1.1 Taxonomy; 2.1.2 Genomic Organization; 2.1.3 Differentiation of C. burnetii Isolates; 2.1.4 Genotyping; 2.2 Comparative Genomics
2.3 Virulence Factors and Host Response Remodeling2.3.1 Phase Variation; 2.3.2 C. burnetii Metabolism and Microaerophilic Requirements; 2.3.3 C. burnetii Uptake; 2.3.4 Adherence of C. burnetii Induces Cellular Responses; 2.3.5 TLR Interactions; 2.3.6 Life Cycle; 2.3.6.1 Small and Large Cell Variants; 2.3.6.2 Parasitophorous Vacuole Development; 2.3.6.3 Interactions Linking the PV with Autophagy and Apoptosis; 2.3.7 Ability to Subvert Oxidative Stress; 2.4 Conclusions; References
Chapter 3: Defense Mechanisms Against Oxidative Stress in Coxiella burnetii : Adaptation to a Unique Intracellular Niche3.1 Oxidative Stress; 3.1.1 Sources of ROS and RNS; 3.1.2 Mechanisms of Cellular Damage; 3.1.3 C. burnetii ;  the Organism and Its Intracellular Niche; 3.2 Defense Mechanisms Against Oxidative Stress in C. burnetii; 3.2.1 Suppression of ROS Production by Secretion of an Acid Phosphatase; 3.2.2 ROS Scavenging Systems; 3.2.2.1 SOD; 3.2.2.2 Catalase; 3.2.2.3 Peroxiredoxins; 3.2.2.4 ROS and RNS Scavenging; 3.2.3 Iron Homeostasis and Oxidative Stress
3.2.4 Regulation of Oxidative Stress Defenses3.3 Oxidative DNA Damage and Repair; 3.3.1 Base Excision Repair (BER); 3.3.2 Nucleotide Excision Repair (NER); 3.3.3 SOS Response and Recombinational DNA Repair; 3.4 Summary and Prospects; References; Chapter 4: Lipopolysaccharide of Coxiella burnetii; 4.1 Introduction; 4.2 Lipopolysaccharide Overview; 4.2.1 Lipopolysaccharide Phase Variation; 4.3 Structural Studies of a Lipopolysaccharide from C. burnetii; 4.3.1 Composition and Structure of LPS II; 4.3.2 Composition and Structure of LPS I; 4.3.3 Composition and Structure of Lipid A
4.4 Biosynthesis of Lipopolysaccharides4.4.1 Nomenclature; 4.4.2 O-Polysaccharide Genetics; 4.4.3 O-Polysaccharide Genetic Analysis of C. burnetii; 4.4.4 O-Polysaccharide Biosynthesis and Export Mechanisms of C. burnetii; 4.4.5 Tentative Biosynthesis Pathway of D-Virenose in C. burnetii; 4.5 Functional Characteristics of the C. burnetii Lipopolysaccharide; 4.6 Summary; References; Chapter 5: Components of Protective Immunity; 5.1 Host Immune Responses to C. burnetii; 5.1.1 Humoral Immune Responses; 5.1.2 Cell-Mediated Immune Responses; 5.2 Vaccine-Induced Protective Immunity; References
Chapter 6: Proteome of Coxiella burnetii
Includes bibliographical references and index.
Over 20 years have elapsed since publication of the seminal two volume series entitled Q Fever: The Biology of Coxiella burnetii (edited by J. C. Williams and H. A. Thompson) and Q fever: The Disease (edited by T. J. Marrie) that described the current state of Coxiella burnetii research. The ensuing years have brought the post-genomic era and accompanying technologies that have catalyzed major advances in the field, including milestones discoveries of genetic transformation and host cell-free growth of this former obligate intracellular bacterium. Understanding how the bacterium resists the degradative functions of vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen.   The book covers the current state-of-the-art knowledge in the selected fields of C. burnetii/Q fever research. Coxiella has matured from a niche organism, investigated by a handful of laboratories worldwide, to a model system to study macrophage parasitism, developmental biology, host-pathogen interactions, and immune evasion/modulation.
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