Sepsis Management [electronic resource] : PIRO and MODS /
Rello, Jordi.editor.
Lipman, Jeffrey.editor.
Lisboa, Thiago.editor.
This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.
Description based upon print version of record.
Sepsis Management; Contents; 1: Multiorgan Dysfunction Syndrome (MODS): What is New?; 1.1 Introduction; 1.2 Current Concepts; 1.2.1 Intensive Care Unit (ICU) Patients Seldom Die from a Single Acute Organ Failure; 1.2.2 Organ Failure Is Often a Marker of the Severity of Illness; 1.2.3 MOF Is a Package; 1.3 Pathophysiology of MODS; 1.4 Prevention and Treatment of MODS; 1.5 Conclusion; References; 2: MODS Scores: Which One Should I Use?; 2.1 Introduction; 2.2 Organ System Failure (OSF) Score; 2.3 Multiple Organ Dysfunction Score (MODS); 2.4 Logistic Organ Dysfunction Score (LODS)
2.5 Sequential Organ Failure Assessment (SOFA) Score2.6 Which System to Use?; 2.7 The Application of MODS in the Daily Life of an ICU; 2.8 Conclusion; References; 3: Why Guidelines Require Reform; 3.1 Introduction; 3.2 Generating Guidelines and the Controversies of Evidence-Based Medicine; 3.2.1 Scope and Purpose; 3.2.2 Stakeholder Involvement; 3.2.3 Rigor of Development; 3.2.4 Clarity and Presentation; 3.2.5 Applicability; 3.2.6 Editorial Independence; 3.3 Implementing Guidelines into Clinical Practice; 3.4 Conclusions; References; 4: PIRO Concept and Clinical Failure; 4.1 Introduction
4.2 Why the PIRO Concept?4.2.1 Predisposition; 4.2.2 Infection; 4.2.3 Response; 4.2.4 Organ Dysfunction; 4.3 PIRO Concept and Clinical Failure; References; 5: PIRO-Based Approach for Sepsis in Immunocompromised Patients: What's Different?; 5.1 Sepsis in HIV/AIDS Patients; 5.1.1 Epidemiology; 5.1.2 Predisposing Factors and Characteristics of Infection in Critically Ill HIV/AIDS Patients; 5.1.3 Response to Infection in HIV-Infected Patients and the Development of Organ Dysfunctions; 5.2 Sepsis in Cancer Patients; 5.2.1 Epidemiology; 5.2.2 Predictors of Sepsis Mortality in Cancer Patients
5.2.3 What Are the Pathogens We Should Look for and Treat in Cancer-Related Sepsis?5.2.4 A PIRO-Based Approach for Patients with Cancer or HIV/AIDS and Sepsis; References; 6: Intra-Abdominal Hypertension and MODS; 6.1 Introduction; 6.2 What is IAH?; 6.3 IAP Measurement; 6.4 How Does IAH Cause MODS?; 6.5 IAH in Sepsis; 6.5.1 IAH in Severe Sepsis and Septic Shock; 6.5.2 IAH in Abdominal Sepsis; 6.6 Implications for Management; 6.6.1 IAH as a Therapeutic Target; 6.6.2 IAH and Treatment of Severe Sepsis and Septic Shock; 6.7 Conclusions; References
7: Assessing Renal Dysfunction in Septic Patients7.1 Introduction; 7.2 Definition; 7.3 Pathogenesis; 7.3.1 Systemic and Regional Blood flow Abnormalities; 7.3.2 Renal Endothelial and Tissue Damage; 7.4 Limitations of Conventional Definitions and Markers of Renal Function; 7.5 Newer Approaches to Assessing Dysfunction and Damage - Biomarkers; 7.6 Supra-Normal Renal Function in Critically Ill Patients; 7.7 Conclusion; References; 8: Monitoring Myocardial Dysfunction as Part of Sepsis Management; 8.1 Introduction; 8.2 Mechanisms of Systolic Cardiac Dysfunction
8.2.1 Role of Circulating Myocardial Depressant Factors
Includes bibliographical references and index.
This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.
Critical care medicine.
Infectious diseases.
Respiratory organs-Diseases.
Anesthesiology.
Internal medicine.
Intensive / Critical Care Medicine.
Infectious Diseases.
Pneumology/Respiratory System.
Anesthesiology.
Internal Medicine.