Natural Products [electronic resource] : Drug Discovery and Therapeutic Medicine /
Zhang, Lixin.editor.
Demain, Arnold L.editor.
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious. State-of-the-art and forward looking, Natural Products: Drug Discovery and Therapeutic Medicine will inspire industrial and academic researchers, practitioners, and developers to once again explore natural products as key sources for the many new drugs needed to solve still unmet medical needs.
Description based upon print version of record.
Includes bibliographical references and index.
Fundamental Issues Related to Natural Product-Based Drug Delivery -- Natural Products and Drug Discovery -- Strategies -- Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products -- Automated Analyses of HPLC Profiles of Microbial Extracts -- Manipulating Microbial Metabolites for Drug Discovery and Production -- Improving Drug Discovery From Microorganisms -- Developments in Strain Improvement Technology -- Specific Groups of Drugs -- The Discovery of Anticancer Drugs From Natural Sources -- Case Studies in Natural-Product Optimization -- Terpenoids As Therapeutic Drugs and Pharmaceutical Agents -- Challenges and Opportunities in the Chinese Herbal Drug Industry -- Arsenic Trioxide and Leukemia -- Microbial Diversity -- New Methods to Access Microbial Diversity for Small Molecule Discovery -- Accessing the Genomes of Uncultivated Microbes for Novel Natural Products -- Specific Sources -- New Natural-Product Diversity From Marine Actinomycetes -- Novel Natural Products From Rainforest Endophytes -- Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador.
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious. State-of-the-art and forward looking, Natural Products: Drug Discovery and Therapeutic Medicine will inspire industrial and academic researchers, practitioners, and developers to once again explore natural products as key sources for the many new drugs needed to solve still unmet medical needs.
Pharmacy.
Pharmacy.