Signal transduction : principles, pathways, and processes /
Cantley, Lewis C.,editor of compilation.
Hunter, Tony,1943-editor of compilation.
Sever, Richard,editor of compilation.
Thorner, Jeremy W.,editor of compilation.
"Signal transduction pathways are molecular circuits that define how cells communicate with each other and respond to their environment. This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes. It starts by describing the basic players - signals, receptors, second messengers, and effectors - before comprehensively mapping the various different signaling pathways that operate in cells. It then goes on to provide detailed descriptions of how signal transduction functions in essential processes such as cell growth and division, metabolism, sensory perception, immunity, and reproduction"--
"This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. It first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function"--
Includes bibliographical references and index.
Machine generated contents note: -- (preliminary) -- Preface -- INTRODUCTION -- I. GENERAL PRINCIPLES AND MECHANISMS -- 1. Signals and Receptors -- Carl Henrik-Heldin, Benson Lu, Ron Evans, and Silvio Gutkind -- 2. General Principles and Mechanisms of Protein Regulation in Signal Transduction -- Michael J. Lee and Michael B. Yaffe -- 3. Second Messengers -- Alexandra Newton and Susan Taylor -- 4. Signaling Networks: Computational Capabilities and Decision-making -- Evren U. Azeloglu and Ravi Iyengar -- II. PATHWAYS/ROAD MAPS -- MAP Kinase Pathways - Deborah Morrison -- PI3K-PKB/Akt Pahway Signaling - Brian A. Hemmings & David F. Restuccia -- mTOR Signaling - Mathieu Laplante and David M. Sabatini -- Calcium Signaling - Martin D. Bootman -- AC-cAMP - Paolo Sassone-Corsi -- Wnt Signaling Pathway - Roel Nusse -- Hedgehog Signaling - Philip W. Ingham -- Notch/APP - Raphael Kopan -- TGF? /Smad - Jeff Wrana -- JAK/STAT Pathway - Douglas A. Harrison --Toll-like Receptor Signaling - Kian Huat Lim and Louis Staudt -- Immunoreceptor Signaling - Lawrence E. Samelson -- Signaling by Nuclear Receptors -Richard Sever & Christopher K. Glass -- Hippo Pathway - Kieran F. Harvey and Iswar K. Hariharan -- III. SIGNALING PROCESSES -- 5. Signaling to the G1 Cell Cycle -- Robert J. Duronio and Yue Xiong -- 6. Signaling Pathways that Regulate Cell Division -- Nicholas Rhind and Paul Russell -- 7. Cell Growth and Metabolism -- Patrick S. Ward and Craig B. Thompson -- 8. Signal Transduction and the Regulation of Cell Migration -- Peter Devreotes and Rick Horwitz -- 9. Signaling Pathways in Cell Polarity -- Luke M. McCaffrey and Ian G. Macara -- 10. Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning -- Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo -- 11. Signaling in Development 2 -- Benjamin Neel and Senthil Muthuswarmy -- 12. Signaling by Sensory Receptors -- David Julius and Jeremy Nathans --13. Synaptic Signaling in Learning and Memory -- Mary B. Kennedy -- 14. Intracellular Calcium Signaling -- Ivana Y. Kuo and Barbara E. Ehrlich -- 15. Organismal Carbohydrate and Lipid Homeostasis -- D. Graham Hardie -- 16. Innate Immunity and Inflammation -- Kim Newton and Vishva Dixit -- 17. Lymphocyte Activation/Behavior -- Doreen Cantrell -- 18. Vertebrate Reproduction -- Sally Kornbluth and Rafael Fissore -- 19. Stress Responses -- Gökhan Hotamisligil and Roger J. Davis -- 20. Cell Death Signaling -- Douglas R. Green and Fabien Llambi -- 21. Cancer -- Joan S. Brugge -- 22. Subversion of Cell Signaling by Pathogens -- Kim Orth and Neal Alto -- Index.
"Signal transduction pathways are molecular circuits that define how cells communicate with each other and respond to their environment. This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes. It starts by describing the basic players - signals, receptors, second messengers, and effectors - before comprehensively mapping the various different signaling pathways that operate in cells. It then goes on to provide detailed descriptions of how signal transduction functions in essential processes such as cell growth and division, metabolism, sensory perception, immunity, and reproduction"--
"This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. It first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function"--
Cellular signal transduction.
Developmental biology.
Pathology, Molecular.
SCIENCE / Life Sciences / Biology / Molecular Biology.
SCIENCE / Life Sciences / Cytology.
SCIENCE / Life Sciences / Biology / Developmental Biology.