Molecular Mechanisms of Xeroderma Pigmentosum [electronic resource] /
Winstel, G.
Ahmad, Shamim.editor.
Hanaoka, Fumio.editor.
To understand the molecular mechanisms of XP, XP mouse models have been used, and mice deficient in XPA, XPC, XPD, XPG, XPF, and XPA/CSB have been produced and analysed. This title includes a chapter that analyzes the world distribution of XP and shows that Japan has the highest incidence of XP and of varying complementation groups.
Description based upon print version of record.
To understand the molecular mechanisms of XP, XP mouse models have been used, and mice deficient in XPA, XPC, XPD, XPG, XPF, and XPA/CSB have been produced and analysed. This title includes a chapter that analyzes the world distribution of XP and shows that Japan has the highest incidence of XP and of varying complementation groups.
Includes bibliographical references and index.
Historical Aspects of Xeroderma Pigmentosum and Nucleotide Excision Repair -- Clinical Features of Xeroderma Pigmentosum -- Xeroderma Pigmentosum and Skin Cancer -- XPA Gene, Its Product and Biological Roles -- XPB and XPD between Transcription and DNA Repair -- XPC: Its Product and Biological Roles -- The XPE Gene of Xeroderma Pigmentosum, Its Product and Biological Roles -- XPF/ERCC4 and ERCC1: Their Products and Biological Roles -- XPG: Its Products and Biological Roles -- Xeroderma Pigmentosum Variant, XP-V: Its Product and Biological Roles -- Other Proteins Interacting with XP Proteins -- The Nucleotide Excision Repair of DNA in Human Cells and Its Association with Xeroderma Pigmentosum -- Roles of Oxidative Stress in Xeroderma Pigmentosum -- Xeroderma Pigmentosum: Its Overlap with Trichothiodystrophy, Cockayne Syndrome and Other Progeroid Syndromes -- Population Distribution of Xeroderma Pigmentosum -- Progress and Prospects of Xeroderma Pigmentosum Therapy -- Animal Models of Xeroderma Pigmentosum.
Molecular biology.
Medicine.
Molecular Medicine.
Biomedicine, general.
Advances in experimental medicine and biology