Mechanisms of Vascular Defects in Diabetes Mellitus [electronic resource] /
Kartha, C.C.editor.
Ramachandran, Surya.editor.
Pillai, Radhakrishna M.editor.
This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered. Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields. This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes.
Includes bibliographical references at the end of each chapters and index.
Section 1 Introduction -- The Global Burden Of Diabetes And Its Vascular Complications -- SECTION 2 Pathogenesis -- Genetic Basis For Increased Risk For Vascular Diseases In Diabetes -- Vascular Remodelling In Diabetes Mellitus -- Pathogenesis Of The Plaque Vulnerability In Diabetes Mellitus -- Endothelial Dysfunction In Diabetes -- Smooth Muscle Cells In Diabetes Mellitus -- Monocytes Factors In Pathogenesis Of Vascular Lesions In Diabetes -- Endothelial Progenitor Cell Dysfunction In The Pathogenesis Of Vascular Complications Of Diabetes -- Pathogenetic mechanisms in diabetic retinopathy: from molecules to cells to tissues -- Perspectives on the vascular pathogenesis of diabetic neuropathy -- SECTION 3 Molecular mechanisms -- The Renin - Angiotensin System And Diabetes -- Adipokines And Vascular Disease In Diabetes -- G-Proteins In Vascular Complications Of Diabetes -- Histone Deacetylases In Vascular Pathophysiology: Regulation By Vasoactive Peptides And Growth Factors -- Role of non-coding RNAs in vascular complications of diabetes mellitus -- SECTION 4 Hemostatic Factors -- Diabetes As A Prothrombotic State -- Mechanisms Of Hypercoagulation And Aberrant Clot Lyses In Type 2 Diabetes -- Platelet Dysfunction In Type-2 Diabetes Mellitus -- SECTION 5 Metabolic Factors -- Advanced Glycation End Products In Diabetic Complications -- Atherogenicdyslipoproteinemia In Type 2 Diabetes Mellitus -- Vascular Remodeling: Homocysteine And Diabetes -- SECTION 6 Pharmacological Therapies -- Mechanisms Of Action Of Drugs For Treating Endothelial Dysfunction In Diabetes Mellitus -- Beneficial Effects Of Inorganic Nitrate/Nitrite On Vascular Function And Blood Pressure In Diabetes -- Myeloperoxidase (MPO): Do We Need Inhibitors?.
This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered. Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields. This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes.
Cell biology.
Diabetes.
Cell Biology.
Diabetes.