99mTc-Sestamibi [electronic resource] : Clinical Applications /
Bucerius, Jan.editor.
Ahmadzadehfar, Hojjat.editor.
Biersack, Hans-Jürgen.editor.
99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that was introduced into clinical routine for myocardial perfusion imaging more than two decades ago. Although today the main application of 99mTc-sestamibi SPECT remains the imaging of myocardial perfusion, it is also an accepted and well-proven imaging technique for a variety of oncologic and non-oncologic applications, including brain, breast, and thyroid cancer and thyroid and parathyroid adenoma. Its efficacy in a range of indications ensures that 99mTc-sestamibi SPECT will remain widely used despite the rapid diffusion of 18F-FDG PET.                         99mTc-Sestamibi – Clinical Applications provides a detailed and informative overview of almost all the oncologic and non-oncologic applications of 99mTc-sestamibi SPECT, including several relatively rare indications. Different disease-related protocols for 99mTc-sestamibi SPECT are presented, and for each disease a comprehensive summary of the relevant pathology and epidemiology is provided. Throughout, there is a strong emphasis on the practical aspects of use of this popular tracer, including instructions for the preparation of several commercially available tracer kits. Clinical practitioners will find this book to be an invaluable guide to the application and benefits of 99mTc-sestamibi SPECT in both the inpatient and the outpatient setting.
Description based upon print version of record.
99mTc-Sestamibi; Foreword; Preface; Contents; 1: Radiochemistry and Radiopharmacy of the SPECT-Tracer Technetium- 99m -Hexakis-2-methoxy-2-isobutyl isonitrile ( 99m Tc-Sestamibi); 1.1 Introduction; 1.2 99m Tc; 1.3 Development of Tc-99m-Labelled Imaging Agents for the Heart; 1.4 Radiolabelling and Quality Control of Tc-99m-Sestamibi; References; 2: Physics and Radiation Exposure; 2.1 Set-Up Chapter; 2.1.1 Radiation Physics 99m Tc-Decay and Imaging Principles; 2.1.2 Attenuation; 2.1.3 Scatter; 2.1.4 Resolution and Partial Volume Effect; 2.1.5 Radiation Dosimetry of 99m Tc MIBI
2.2 Biokinitic of 99m Tc MIBI2.3 Blood Clearance; 2.4 Upper-Body Organ Distribution; 2.5 Heart-to-Organ Ratios; 2.6 Radiation Dosimetry; 2.7 Radiation Exposure from Myocardial Perfusion Agents; Reference; 3: Preparation of Tc-99m-Sestamibi; 3.1 Chemistry and Constituents; 3.2 Photon Energy; 3.3 Organs at Risk for Tc-99m-sestamibi; 3.4 Special Warning and Precautions for Use [ 1 ]; 3.5 Interaction with Other Medicinal Products and Other Forms of Interaction; 3.6 Effects on Ability to Drive and Use Machines; 3.7 Undesirable Effects [ 1 ]; 3.8 Overdosage; 3.9 Technical Aspects; 3.9.1 Preparation
3.9.2 Quality Control [ 1 ]3.10 Radio-TLC Method for the Quantification of Tc-99m-sestamibi; References; 4: Parathyroid Imaging; 4.1 Introduction: Parathyroid Glands; 4.2 Methods/Image Acquisition (Fig. 4.1); 4.2.1 Parathyroid Imaging: Subtraction and Dual-Tracer Technique; 4.2.2 SPECT for Sestamibi Parathyroid Scintigraphy; 4.2.3 Recommended Injected Activity and Dosimetry; 4.2.4 General Considerations for Parathyroid Imaging; 4.2.5 Sestamibi and Histology in Parathyroid Adenoma; 4.2.6 Parathyroid Imaging in Patients with Concomitant Thyroid Disease; 4.2.7 Pitfalls in Parathyroid Imaging
4.2.8 Intraoperative Parathyroid Detection4.2.9 Cost-Effectiveness of Sestamibi; 4.3 Indications for Parathyroid Imaging; 4.3.1 Primary HPT; 4.3.1.1 Preoperative Imaging; 4.3.2 Secondary HPT; 4.3.2.1 Recurrent or Persistent HPT; 4.4 Sensitivity and Specificity of 99m Tc-Sestamibi in Patients with HPT; 4.5 Comparison of 99m Tc-Sestamibi and Other Diagnostic Imaging Modality Results in Patients with HPT; 4.6 Radiation Exposure for Different Radiopharmaceuticals; 4.7 Summary and Conclusion; 4.7.1 Preoperative Parathyroid Imaging; 4.8 Conclusion; 4.8.1 Persistent or Recurrent HPT; References
5: Myocardial Perfusion Scintigraphy with 99mTc-MIBI5.1 Kinetics and Scientific Basis of Myocardial Perfusion Imaging with Tc-MIBI; 5.1.1 Photon Energy; 5.1.2 Physical and Biological Half-Life; 5.1.3 Radiation Exposure Levels to the Patients, Hospital Staff, and to Relatives of Patients and a Comparison Between Tc-99m-Labeled Tracers and Tl-201; 5.1.4 Initial Myocardial Uptake of Tc-MIBI; 5.1.5 Myocardial Redistribution; 5.1.6 Blood Clearance; 5.1.7 Biodistribution at Rest and Stress; 5.2 Tc-MIBI as an Agent for Myocardial Perfusion Imaging; 5.3 Exercise and Pharmacologic Stress Testing
5.4 Stress-Only Myocardial Perfusion SPECT with Tc-MIBI
Includes bibliographical references and index.
99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that was introduced into clinical routine for myocardial perfusion imaging more than two decades ago. Although today the main application of 99mTc-sestamibi SPECT remains the imaging of myocardial perfusion, it is also an accepted and well-proven imaging technique for a variety of oncologic and non-oncologic applications, including brain, breast, and thyroid cancer and thyroid and parathyroid adenoma. Its efficacy in a range of indications ensures that 99mTc-sestamibi SPECT will remain widely used despite the rapid diffusion of 18F-FDG PET.                         99mTc-Sestamibi – Clinical Applications provides a detailed and informative overview of almost all the oncologic and non-oncologic applications of 99mTc-sestamibi SPECT, including several relatively rare indications. Different disease-related protocols for 99mTc-sestamibi SPECT are presented, and for each disease a comprehensive summary of the relevant pathology and epidemiology is provided. Throughout, there is a strong emphasis on the practical aspects of use of this popular tracer, including instructions for the preparation of several commercially available tracer kits. Clinical practitioners will find this book to be an invaluable guide to the application and benefits of 99mTc-sestamibi SPECT in both the inpatient and the outpatient setting.
Nuclear medicine.
Radiology.
Cardiology.
Oncology  .
Nuclear Medicine.
Imaging / Radiology.
Cardiology.
Oncology.