Proteomics  of Spermatogenesis [electronic resource] /
Gupta, G. S.author.
Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine. Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest. "This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm." Pawan K. Singal St. Boniface General Hospital Research Center .
Description based upon print version of record.
Includes bibliographical references and index.
Spermatogenesis -- Paracrine Role of Sertoli Cell -- Non-Steroidal Signal Molecules in Spermatogenesis -- Specificity of Retinol, Estrogen and Steroid Linked Proteins -- Homeostasis of Germ Cells and Apoptosis -- Nuclear Skeleton Proteins: Non-Histones -- Nuclear Skeleton Proteins: Chromosomal Basic Proteins -- Microtubules -- Microtubule Based Motor Proteins -- Sex Chromosomal Proteins and Autosomal Homologues -- Cell Cycle Components -- Isoproteins in DNA Synthesis -- DNA Repair and Recombination -- Transcriptional Control -- Proteins in Transcriptional Activity of Spermatogenic Cells -- Transcription Factors Associated with Spermatogenesis -- Proto-Oncoproteins -- G Proteins and Associated Signal Transduction Molecules -- Protein Kinases -- Protein Phosphatases -- Ion Channels and Aquaporins -- Action of Phospholipases -- Acrosomal Enzymes -- Acrosomal Proteins (Non-Enzymatic) -- Actins and Myosins -- Cell Adhesion Proteins -- Metalloproteases and Metalloprotease Inhibitors -- Isoenzymes in Energy Pathways -- Fibrous Sheath, Dense Fibers, and Plasma Membrane of Sperm -- Proteins in Antiperoxidation -- Quality Control of Germ Cell Proteins -- Cancer Associated Testis Antigens -- Selective Group of Germ Cell Specific Proteins -- Sperm Maturation in Epididymis.
Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine. Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest. "This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm." Pawan K. Singal St. Boniface General Hospital Research Center .
Proteomics.
Cell biology.
Proteomics.
Cell Biology.