High Altitude [electronic resource] : Human Adaptation to Hypoxia /
Swenson, Erik R.editor.
Bärtsch, Peter.editor.
Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude.  Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases.  Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients.  High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases.
Description based upon print version of record.
Preface; Contents; Contributors; 1: Cellular and Molecular Mechanisms of O 2 Sensing; The Evolution of Oxygen Sensing Systems; Systemic and Specialized Mammalian Oxygen Sensing Systems; Characteristics of an Oxygen Sensor; Definition of an Oxygen Sensor; Biophysical Properties of an O 2 Sensor; Proposed Models of O 2 Sensing; O 2 Sensing Heme Proteins; NAD(P)H (NOX) Oxidases; O 2 -Sensitive Ion Channels; Hypoxia-Inducible Factors and the Role of Prolyl Hydroxylases as O 2 Sensors; Nitric Oxide Participation in the O 2 Sensing Pathway Regulating HIF; Mitochondrial Oxygen Sensing
The Mitochondrial ROS HypothesisHypoxia-Induced ROS Signaling in the Mitochondrial Intermembrane Space; Independent Confirmation of the Mitochondrial O 2 Sensing Hypothesis; Mitochondrial ROS Regulate AMPK Responses to Hypoxia; References; 2: Cellular and Molecular Defenses Against Hypoxia; Effects of Hypoxia on Transcription; Hypoxia-Inducible Transcription Factors: HIFs; Nuclear Factor Kappa B: NF-κB; Cyclic AMP Response Element Binding Protein; Effects of Hypoxia on Translation; Acute Cellular Responses to Hypoxia; Metabolic Changes; Impact of Reactive Oxygen Species
Effects of Hypoxia on Cell Motility, Invasiveness, and DifferentiationChronic Responses to Hypoxia; Role of Erythropoietin; Tissue Protection by Hypoxic Preconditioning; Regulation of Iron Metabolism as Protective Mechanism; Induction of Angiogenesis and Vascular Remodelling; Conclusions; References; 3: Control of Breathing; Ventilatory Acclimatization to High Altitude and the Increase in the Hypoxic Ventilatory Response; Mechanisms Contributing to VAH; Role of Carotid Bodies and Peripheral Chemoreceptors; Crucial Role of the Carotid Bodies in VAH; Oxygen Sensing in the Carotid Bodies
Neurochemical and Membrane Ion Channel AdaptationsMorphological Changes in the Carotid Bodies; Role of Central Nervous System Changes to HVR and VAH; Role of Carotid Bodies in CO 2 Sensitivity; Role of Acid-Base Status and Central Chemoreceptors?; Conclusion; References; 4: Lung Function and Gas Exchange; Introduction; Pulmonary Function; Spirometry and Lung Volumes; Closing Volume and Closing Capacity; Diffusion Capacity; Airways Resistance; Airway Hyperresponsiveness; Respiratory Muscle Strength; Lung Compliance; Work of Breathing; Extravascular Lung Water at High Altitude; Gas Exchange
OverviewOxygen Availability; Barometric Pressure Variation; Resting Pulmonary Gas Exchange; Arterial Blood Gases; Gas Exchange Efficiency: The Alveolar-Arterial Difference; Ventilation-Perfusion Inequality; Diffusion Limitation; Shunt; Hemoglobin Saturation; Differences Between Field Studies and Chamber Studies; Pulmonary Gas Exchange During Exercise; Arterial Blood Gases; Gas Exchange Efficiency; Ventilation-Perfusion Inequality; Diffusion Limitation; Special Considerations; High Altitude Peoples; Exposure to High Altitude During Growth and Development
The Effect of Lifelong High Altitude Exposure on Pulmonary Gas Exchange
Includes bibliographical references and index.
Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude.  Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases.  Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients.  High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases.
Respiratory organs—Diseases.
Internal medicine.
Human physiology.
Pneumology/Respiratory System.
Internal Medicine.
Human Physiology.