Epigenetics, Brain and Behavior [electronic resource] /
Sassone Corsi, Paolo.editor.
Christen, Yves.editor.
What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.
Description based upon print version of record.
Epigenetics, Brain and Behavior; Foreword; Contents; Contributors; Nucleosome Remodelling and Epigenome Diversification; 1 Introduction; 2 Transcription Control: Harnessing Remodelers to Install Neuronal Differentiation Programs; 3 Global Phenomena - Epigenome Diversification; 4 Conclusion; References; Synaptic Epigenesis and the Evolution of Higher Brain Functions; 1 Introduction; 2 Defining Synaptic Epigenesis; 3 Social and Cultural Evolution; 4 Synaptic Selection and Stabilization; 5 Epigenetics and Higher Brain Function; 6 Where Next?; References
Plasticity of the Circadian System: Linking Metabolism to Epigenetic Control1 Circadian Clock and System Biology; 2 The circadian transcriptome; 3 Chromatin Remodeling and Epigenetic Control of Circadian Expression; 4 NAD+ as a Central Circadian Regulator; References; Epigenetics and the Environmental Regulation of Genomic Structure and Function: Implications for Health; 1 Regulation of Glucocorticoid Receptor Expression; 2 Epigenetics and the Social Environment; 3 Implications for Mental Health; 4 Environmental Epigenetics and Immune Function
5 Epigenetic Modifications Modulate the Differentiation of Immune Cell Subtypes6 Epigenetics and Psychoneuroimmunology; References; Epigenetic Inheritance in Mammals; 1 Introduction; 2 Diet; 3 Environmental Toxicants; 4 Trauma in Early Life; 5 Enriched Environment; 6 Conclusions; References; Control of Neuronal Gene Transcription and Behavior by the Epigenetic Suppressor Complex G9a/GLP; 1 Introduction; 2 Loss of G9a/GLP in Postnatal Neurons Erases Euchromatic H3K9me2; 3 Postnatal, Neuron-Specific Loss of GLP/G9a in Mice Reproduces key Signs of Severe Human Mental Retardation Syndrome
4 Transcriptional de-Differentiation of Adult Neurons Lacking H3K9me25 Conclusions and Discussion; References; The Role of Histone Acetylation in Long-Term Memory Storage; 1 Contextual Learning Induces CREB-Dependent Changes in Gene Expression in the Hippocampus; 2 The Role of Histone Acetyltransferases in Long-Term Memory; 3 Acetylation of Specific Lysine Residues on Histone Tails May Be Important During Memory Consolidation; 4 Histone Deacetylase Inhibitors Increase Long-Term Memory; 5 Overview and Future Directions; References; DNA Methylation in Memory Formation; 1 Introduction
2 DNA Methylation as a Candidate Stable Molecular Mark in Cells3 Recent Evidence Implicating DNA Methylation in Memory Consolidation; 4 Regulation of DNA Demethylation; 5 How Does Altered Methylation Lead to Altered Neuronal Function? The LTP Hypothesis; 6 Implications for Memory Storage at the Cellular Level; 7 Summary and Open Questions; References; Epigenetic Mechanisms Regulating Memory Formation in Health and Disease; 1 Histone Deacetylases and Cognition; 2 p25/Cdk5 And Neurodegeneration; 3 CK-p25 Mouse Model
4 HDAC Inhibitor Treatment Reinstated Learning and Restored Remote Memory After Neurodegeneration
Includes bibliographical references and index.
What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.
Neurosciences.
Human genetics.
Neurosciences.
Human Genetics.
Research and Perspectives in Neurosciences