Selenoproteins and Mimics [electronic resource] /
Liu, Junqiu.editor.
Luo, Guimin.editor.
Mu, Ying.editor.
Selenium has a long history of association with human health and disease. This essential trace element exerts its important biological role in selenoproteins. "Selenoproteins and Mimics" presents the latest developments in selenoproteins, their functional imitation by biomimetic chemistry and biology, and their relationship with human health and diseases. This book provides both the basic biology and biochemistry knowledge of selenoproteins, and sophisticated approaches for the development of new selenoprotein mimics. It's a valuable reference for researchers in biological technology, chemical syntheses, and medicine design. Junqiu Liu is a professor at the State Key Lab of Supramolecular Structure and Materials, Jilin University, China. Guimin Luo is a professor at the Key Lab of Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, China.Ying Mu is a professor at the State Key Lab of Industrial Control Technology, Zhejiang University, and guest professor at the Key Lab of Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, China.
Description based upon print version of record.
Title Page; Copyright Page; Foreword; Preface; Table of Contents; Contributors; 1 Glutathione Peroxidases; 1.1 Introduction; 1.2 Glutathione Peroxidase Reaction; 1.2.1 Basic Catalytic Principle; 1.2.2 Kinetics; 1.2.3 Physiological Consequences of Kinetic Mechanism; 1.2.4 Facts, Unknowns and Guesswork; 1.2.4.1 Catalytic Relevance of UP or CP Dissociation; 1.2.4.2 Mechanism of UP Activation; 1.2.4.3 Chemical Nature of Oxidized GPx; 1.2.4.4 Structures and Substrate Specificities; 1.3 Biological Roles of Individual Glutathione Peroxidases; 1.3.1 GPx1; 1.3.2 GPx2; 1.3.3 GPx3; 1.3.4 GPx4
1.3.5 GPx5-GPx81.4 Conclusions and Perspectives; References; 2 Thyroid Hormone Deiodinases; 2.1 Introduction; 2.2 Thyroid Hormones; 2.3 Deiodinases; 2.3.1 Structure; 2.3.2 Control; 2.4 Role of Deiodinase in TH Actions; 2.4.1 Photoperiod; 2.4.2 Nutrition; 2.4.3 Thermogenesis; 2.4.4 Osmoregulation; 2.4.5 Reproduction; 2.4.6 Development, Including Metamorphosis; 2.4.7 Developmental Genes; 2.5 Evolution; References; 3 Thioredoxin Reductase; 3.1 Introduction; 3.2 Selenium in Mammalian TrxR; 3.3 Outline of Mammalian TrxR; 3.3.1 Isoenzymes; 3.3.2 Sec Incorporation; 3.3.3 cDNAs and Genes
3.4 Regulation of Mammalian TrxR3.4.1 Se-dependent Regulation; 3.4.1.1 Regulation of TrxR Protein by Se Nutritional Status; 3.4.1.2 Regulation of TrxR mRNA Levels by Se Nutritional Status; 3.4.2 Regulation of Gene Expression; 3.4.2.1 TrxR-I Promoter; 3.4.2.2 Regulating Factors; 3.5 Structure; 3.5.1 Functional Elements in Primary Structure; 3.5.2 Functional Elements in Three-dimensional Structure; 3.5.2.1 Sec498Cys Mutant of Rat TrxR-I; 3.5.2.2 Sec498Cys Mutant of Human TrxR-I; 3.5.2.3 Rat Sec-containing TrxR-I; 3.5.2.4 Sec-to-Cys Mutant of Mouse TrxR-II
3.6 Proposed Mechanisms Underlying TrxR-I Catalysis3.6.1 Electron Transfer Pathway; 3.6.2 Acid-base Catalyst; 3.6.3 Catalytic Roles of the Sec Residue; 3.6.3.1 Reduction of Trx; 3.6.3.2 Reduction of H2O2; 3.7 Roles of Mammalian TrxRs in Cell Growth and Apoptosis; 3.7.1 Cross-talk with Glutathione System; 3.7.2 Control of Cell Growth; 3.7.2.1 Mediating Effects of Se; 3.7.2.2 Transferring Electrons to Ribonucleotide Reductase; 3.7.2.3 Mediating Interferons' Action; 3.7.3 Regulation of Apoptosis; 3.7.3.1 Modulating Activities of p53/ASK-1 Pathway; 3.7.3.2 Interacting with other Antioxidants
AcknowledgementsReferences; 4 Selenophosphate Synthetase; 4.1 Introduction; 4.2 Selenoprotein Biosynthesis in Prokaryotes; 4.3 Structure of PurM Monomer and Selenophosphate Synthetase; 4.3.1 Structure of PurM Monomer; 4.3.2 Structure of Human SPS1; 4.4 Cayalytic Mechanism of Selenophosphate Synthetase; 4.5 SelD for Development and Cell Proliferation; 4.6 Conclusion; References; 5 Selenoprotein P; 5.1 Introduction; 5.2 Structural Features of SeP; 5.2.1 Selenium Content of Human SeP; 5.2.2 Proteolysis of Human SeP; 5.3 Molecular Function of SeP; 5.3.1 Enzymatic Properties of Human SeP
5.3.2 Selenium Supplier
Includes bibliographical references and index.
Selenium has a long history of association with human health and disease. This essential trace element exerts its important biological role in selenoproteins. "Selenoproteins and Mimics" presents the latest developments in selenoproteins, their functional imitation by biomimetic chemistry and biology, and their relationship with human health and diseases. This book provides both the basic biology and biochemistry knowledge of selenoproteins, and sophisticated approaches for the development of new selenoprotein mimics. It's a valuable reference for researchers in biological technology, chemical syntheses, and medicine design. Junqiu Liu is a professor at the State Key Lab of Supramolecular Structure and Materials, Jilin University, China. Guimin Luo is a professor at the Key Lab of Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, China.Ying Mu is a professor at the State Key Lab of Industrial Control Technology, Zhejiang University, and guest professor at the Key Lab of Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, China.
Proteins .
Medical biochemistry.
Medicinal chemistry.
Protein Science.
Medical Biochemistry.
Medicinal Chemistry.
Advanced topics in science and technology in China