Bacterial Adhesion [electronic resource] : Chemistry, Biology and Physics /
Linke, Dirk.editor.
Goldman, Adrian.editor.
Adhesion plays a major role in the bacterial lifestyle. Bacteria can adhere to organic and inorganic surfaces, to each other, and of course to host cells during pathogenesis. The focus of this book is: how are such adhesion phenomena best studied? Microbial genetics experiments have greatly enhanced our knowledge of what bacterial factors are involved in adhesion. For numerous reasons, though, biochemical and structural biology knowledge of the molecular interactions involved in adhesion are limited. One major problem has been a lack of interdisciplinary research and understanding in the field. On the one hand, the microbiologists lack detailed knowledge of the biophysical possibilities and have limited access to the frequently expensive instrumentation involved while on the other hand, the experts in these methods frequently do not have access to the biological materials, nor do they necessarily understand the biological questions to be answered. The purpose of this book is thus to overcome this gap in communication between researchers in biology, chemistry and physics and to display the many ways and means to investigate bacterial adhesion. We hope to stimulate new and ground-breaking research.
Description based upon print version of record.
Introduction; References; Contents; Contributors; 1 Adhesins of Human Pathogens from the Genus Yersinia; 1.1 Introduction; 1.2 The Human Pathogenic Yersiniae; 1.2.1 Enteropathogenic Yersiniae; 1.2.2 Yersinia pestis; 1.3 Adhesins of Human Pathogenic Yersiniae; 1.3.1 Invasin; 1.3.2 YadA; 1.3.3 Ail; 1.3.4 Adhesins of Y. pestis; 1.4 Conclusions; References; 2 Adhesive Mechanisms of Salmonella enterica; 2.1 Introduction; 2.2 Pathogenesis of Infections with Salmonella enterica; 2.3 Atypical Adhesive Structures in Salmonella; 2.4 Fimbrial Adhesins; 2.4.1 Chaperone-Usher Assembled Fimbrial Adhesins
2.4.2 Long Polar Fimbriae2.4.3 Thin Aggregative Fimbriae: Assembly Through the Nucleation-Precipitation Pathway; 2.4.4 Type IV Pili; 2.5 Non-fimbrial Adhesins; 2.5.1 Adhesins Secreted by Type I Secretion Systems; 2.5.2 Autotransported Adhesins; 2.6 Complexity of Adhesive Mechanisms in Salmonella enterica; 2.7 Conclusions and Outlook; References; 3 Adhesion Mechanisms of Borrelia burgdorferi; 3.1 Introduction; 3.2     Borrelia burgdorferi Proteins That Promote Interaction with the Extracellular Matrix; 3.2.1 Attachment to Fibronectin; 3.2.2 Attachment to Decorin
3.2.3 Attachment to Glycosaminoglycans3.2.4 Attachment to Laminin; 3.2.5 Erps and CRASPs: Binding to Complement-Regulatory Proteins Factor H and FHL; 3.2.6 Attachment to Mammalian Cell Surface Receptors; 3.2.6.1 Attachment to Integrins; 3.2.7 Candidate Mammalian Substrate Adhesins of B. burgdorferi; 3.2.8 Interaction of    Borrelia burgdorferi with the Arthropod Host; 3.3 Concluding Remarks; References; 4 Adhesins of Bartonella spp.; 4.1 Introduction; 4.1.1 Cat Scratch Disease; 4.1.2 Carrión's Disease; 4.1.3 Trench Fever; 4.1.4 Bacillary Angiomatosis and Peliosis Hepatis
4.2    Analysis of    Bartonella spp. Pathogenicity Factors4.2.1 The VirB/D4 T4SS; 4.2.2 Bartonella Adhesin A (BadA); 4.2.3 Does an Interplay Between the VirB/D4 T4SS and BadA Exist?; 4.2.4 Filamantous Haemagglutinin of Bartonella spp.; 4.2.5 The Trw Type 4 Secretion System of Bartonella spp.; 4.2.6 Less Characterized Adhesins of Bartonella spp.; 4.3 Conclusions and Outlook; References; 5 Adhesion Mechanisms of Plant-Pathogenic Xanthomonadaceae; 5.1 Introduction; 5.2 Adhesive Structures -- Polysaccharides; 5.2.1 Lipopolysaccharides; 5.2.2 Exopolysaccharides
5.3 Adhesive Structures -- Proteins5.3.1 Pili (Fimbriae); 5.3.1.1 Chaperone/Usher Pili; 5.3.1.2 Type IV Pili; 5.3.2 Non-Fimbrial Adhesins; 5.3.2.1 Type V-Secreted Adhesins; 5.3.2.2 Other Outer Membrane Adhesins; 5.4 Adhesin Repertoires and Diversifying Selection; 5.5 Adhesin Receptors; 5.6 Concluding Remarks; References; 6 Adhesion by Pathogenic Corynebacteria; 6.1 Introduction; 6.2 Corynebacterium Diphtheriae and Clinical Disease; 6.3 History of Diphtheria; 6.4 Epidemiology of Diphtheria; 6.5 Adherence Factors of Corynebacteria; 6.5.1 Cell-Wall-Anchored Surface Proteins
6.5.2 Sortase-Mediated Pilus Assembly in Corynebacterium Diphtheriae
Includes bibliographical references and index.
Adhesion plays a major role in the bacterial lifestyle. Bacteria can adhere to organic and inorganic surfaces, to each other, and of course to host cells during pathogenesis. The focus of this book is: how are such adhesion phenomena best studied? Microbial genetics experiments have greatly enhanced our knowledge of what bacterial factors are involved in adhesion. For numerous reasons, though, biochemical and structural biology knowledge of the molecular interactions involved in adhesion are limited. One major problem has been a lack of interdisciplinary research and understanding in the field. On the one hand, the microbiologists lack detailed knowledge of the biophysical possibilities and have limited access to the frequently expensive instrumentation involved while on the other hand, the experts in these methods frequently do not have access to the biological materials, nor do they necessarily understand the biological questions to be answered. The purpose of this book is thus to overcome this gap in communication between researchers in biology, chemistry and physics and to display the many ways and means to investigate bacterial adhesion. We hope to stimulate new and ground-breaking research.
Medicine.
Biology—Technique.
Microbiology.
Medical microbiology.
Biophysics.
Biological physics.
Proteins .
Biomedicine, general.
Biological Techniques.
Microbiology.
Medical Microbiology.
Biological and Medical Physics, Biophysics.
Protein Structure.
Advances in experimental medicine and biology