Management of Prostate Cancer [electronic resource] : A Multidisciplinary Approach /
Bolla, Michel.editor.
van Poppel, Hendrik.editor.
This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included. In addition, the EAU guidelines are presented and advice is given on the interpretation of results. The authors are all experts in their field, and the editors are members of the EORTC who have coordinated phase III EORTC trials and have worldwide reputations.
Description based upon print version of record.
Management of Prostate Cancer; Copyright Page; Preface; Contents; 1: Epidemiology of Prostate Cancer in Europe; 1.1 Prostate Cancer; 1.2 Prostate Cancer Incidence; 1.2.1 Current Situation: Global Incidence in 2008; 1.2.2 Incidence Trends in Europe; 1.2.2.1 Northern Europe; 1.2.2.2 Western Europe; 1.2.2.3 Southern Europe; 1.2.2.4 Eastern Europe; 1.3 Prostate Cancer Mortality; 1.3.1 Current Situation: Global Mortality in 2008; 1.3.2 Mortality Trends in Europe; 1.3.2.1 Northern Europe; 1.3.2.2 Western Europe; 1.3.2.3 Southern Europe; 1.3.2.4 Eastern Europe; 1.4 Prostate Cancer Survival
1.5 Prostate Cancer Prevalence1.6 Risk Factors for Prostate Cancer; 1.6.1 Age; 1.6.2 Family History and Genetics; 1.6.3 Ethnicity; 1.6.4 Androgens; 1.6.5 Diet; References; 2: Chemoprevention of Prostate Cancer; 2.1 Introduction; 2.2 Anti-inflammatory and Antioxidants; 2.2.1 COX-2 Inhibitors; 2.2.2 Selenium (Se) and Vitamin E; 2.3 Dietary Supplements; 2.3.1 Isoflavones; 2.3.2 Lycopene; 2.3.3 Polyphenols; 2.4 Hormonal Prevention of PCa; 2.4.1 Rationale for Hormonal Prevention of PCa; 2.4.2 Randomized Controlled Trials with Chemo "Hormono" Prevention; 2.4.2.1 SERMS
2.4.2.2 5ARIs Finasteride and Dutasteride2.4.3 Balancing the Benefits and Risks of 5ARIs for Prostate Cancer Risk Reduction; 2.5 Conclusions and Future Perspectives; References; 3: Individual and Mass Screening; 3.1 Introduction; 3.2 Screening Instruments: PSA, DRE, TRUS and the Prostate Biopsy; 3.2.1 PSA Velocity; 3.2.2 DRE; 3.2.3 TRUS; 3.2.4 Diagnosis by Biopsy; 3.3 Mass Screening for Prostate Cancer; 3.3.1 Randomized Control Trials for Prostate Cancer Screening; 3.3.2 Results of RCTs in Mass Screening
3.3.3 Potential Harms of Prostate Cancer Screening: Overdiagnosis, Overtreatment,  Quality of Life3.3.4 Interval Cancers; 3.4 Risk Factors in Mass Screening Studies; 3.5 Individual Screening; 3.5.1 Risk Assessment Strategies; 3.5.2 Nomograms; 3.5.2.1 Improving Nomograms; 3.6 Conclusions and Way to Go; References; 4: Anatomo-Pathology; 4.1 Gross Anatomy of the Prostate: Clinical Importance; 4.1.1 The Boundaries of the Prostate; 4.1.1.1 Denonvillier's or Posterior Prostatic Fascia; 4.1.1.2 The Endopelvic Fascia and Pubovesical Ligaments; 4.1.1.3 The Inferior Boundary of the Prostate
4.1.2 Prostate Lobes4.1.3 McNeal's Four Prostate Regions; 4.1.3.1 The Anterior Fibromuscular Stroma; 4.1.3.2 The Central Zone; 4.1.3.3 The Transition and Peripheral Zone; 4.1.4 Prostate Zones and Cancer; 4.2 Microscopic Anatomy of the Prostate; 4.2.1 Prostate Zones: Age-Related Microscopic Changes; 4.2.2 Androgen Deprivation-Induced Changes; 4.3 Precursor Lesions of Prostate Cancer (H-PIN); 4.3.1 High-Grade Prostatic Intraepithelial Neoplasia; 4.3.2 Intraductal Carcinoma; 4.4 Prostate Cancer; 4.4.1 Types and Variants of Adenocarcinoma
4.4.1.1 Conventional Acinar Adenocarcinomas and Its Variants
Includes bibliographical references and index.
This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included. In addition, the EAU guidelines are presented and advice is given on the interpretation of results. The authors are all experts in their field, and the editors are members of the EORTC who have coordinated phase III EORTC trials and have worldwide reputations.
Oncology  .
Urology.
Radiotherapy.
Epidemiology.
Cancer research.
Oncology.
Urology.
Radiotherapy.
Epidemiology.
Cancer Research.