Autoimmune Hepatitis [electronic resource] : A Guide for Practicing Clinicians /
Hirschfield, Gideon M.editor.
Heathcote, E. Jenny.editor.
With a focus on practical patient related issues, Autoimmune Hepatitis: A Guide for Practicing Clinicians serves as a useful practical, and much needed, resource for all those physicians presented with managing patients diagnosed with autoimmune hepatitis, both acutely and over the long term. It provides a basis for clinicians to understand the etiology of the disease, as well as special circumstances where management dilemmas often arise. Emphasis is given to providing management advice of immediate use to clinicians, something not presently offered by other larger general texts. The chapters are written by those with an expertise and training in this field and include the most up to date information. This book is of great value to Gastroenterologists, Hepatologists, and Internists at all levels who see patients presenting with autoimmune hepatitis.
Description based upon print version of record.
Autoimmune Hepatitis; Preface; Contents; Contributors; Chapter 1: Introduction; Chapter 2: The Pathogenesis of Autoimmune Hepatitis; Introduction; The Liver as an Organ of Immunity; Pathogenesis of Autoimmune Hepatitis: Interplay of Susceptibility, Immune Responses, and Immunoregulation; Genetic Factors in Pathogenesis; HLA Class I, II, and III Molecules; Class I HLA; Class II HLA; Type I Autoimmune Hepatitis; Type 2 Autoimmune Hepatitis; Class III HLA; Non-HLA Genes; CTLA-4; Cytokines; Fas; Vitamin D Receptor; Autoimmune Regulator 1; Gender; Environmental Factors in Pathogenesis
Viral InfectionsDrugs and Xenobiotics as Triggers; Immune Reactions and Regulation in Pathogenesis; Histopathology; Cellular Immunity; Oligoclonal T Cells and Liver-Specific Autoantigens; Role of ?(Gamma)/ d(Delta)T Cells; Role of Macrophages; Pivotal Role of Immunoregulation; Treg Deficiencies; Restoration of Treg Function; Humoral Immunity; Role of B Cells and Antibodies; Autoantibodies and Type I AIH; Autoantibodies in Type 2 AIH; Role of Cytokines in Hepatic Fibrosis and Progression to Cirrhosis; A Working Model of AIH Pathogenesis; Genetic Susceptibility
Evolution of a Permissive Immune RepertoireEnvironmental Triggers and Permissive Hepatic Microenvironment; Presentation of Hepatocyte Autoantigens or Molecular Mimics; Activation of Autoreactive T Cells and B Cells; Production of Autoantibodies; Failure of Immunoregulation; Intensification of Immunopathology: Bias Toward CD4 Th1, CD8 CTL, and Activated Effector Mechanisms; Regulation of Hepatocyte Cytolysis; Evolution of Effector Cells and Cytokines; Positive Feedback for Fibrogenesis Resulting in Accelerated Bridging Fibrosis and Progression to Cirrhosis; Appendix; Immune Responses: A Primer
Innate ImmunityPattern Recognition Receptors (PRRs) and Pathogen-Associated Molecular Patterns (PAMPs); Damage-Associated Molecular Patterns; Proinflammatory and Immunosuppressive Cytokines; NK Cells; NKT Cells; Adaptive Immunity; T Cell Receptors and HLA Class I, II, and III Molecules; Selection of the Immune Repertoire and Natural T Regulatory Cells; Costimulation; Dynamic Family of CD4 T Cells; CD8 T Cells; ?(Gamma)/d(Delta) T Cells; B Cell Activation and Functions; Generation of T and B Effector Cell Responses; Immunoregulation of Immune Responses; T Regulatory Cells
Regulatory Dendritic CellsTh17 Cells and Immunoregulation; Liver as an Organ of Adaptive Immunity; Alternatives to an Autoimmune Pathogenesis; References; Chapter 3: Clinical Presentation; Introduction; The Many Faces of Autoimmune Hepatitis; Acute AIH; Confirmation of Diagnosis of AIH; Chronic Autoimmune Hepatitis; Fulminant AIH; Recurrence of AIH Postliver Transplantation; Overlapping Autoimmune Hepatitis and Sclerosing Cholangitis; Overlapping Autoimmune Hepatitis and Primary Biliary Cirrhosis; Clinical Presentation AIH According to Ethnicity; African Americans/Blacks; South America
North American Indigenous Peoples
Includes bibliographical references and index.
With a focus on practical patient related issues, Autoimmune Hepatitis: A Guide for Practicing Clinicians serves as a useful practical, and much needed, resource for all those physicians presented with managing patients diagnosed with autoimmune hepatitis, both acutely and over the long term. It provides a basis for clinicians to understand the etiology of the disease, as well as special circumstances where management dilemmas often arise. Emphasis is given to providing management advice of immediate use to clinicians, something not presently offered by other larger general texts. The chapters are written by those with an expertise and training in this field and include the most up to date information. This book is of great value to Gastroenterologists, Hepatologists, and Internists at all levels who see patients presenting with autoimmune hepatitis.
Gastroenterology .
Hepatology.
Internal medicine.
Gastroenterology.
Hepatology.
Internal Medicine.


Clinical gastroenterology