Stem Cells and Cancer Stem Cells, Volume 7 [electronic resource] : Therapeutic Applications in Disease and Injury /
Hayat, M.A.editor.
This seventh volume in the Springer's landmark series of edited books discusses one of the most important subjects in contemporary medicine and scientific endeavors. The volume presents a staggering range of research into medical applications of stem cells and cancer stem cells. While stem cells are essential for normal life of multicellular organisms, including humans, cancer stem cells are a morbid entity having a robust resistance to therapies including conventional chemotherapy and radiotherapy. This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.
Description based upon print version of record.
Stem Cells and Cancer Stem Cells; One Point of View; Overtreatment; References; Preface; Contents; Contributors; Part I: Regenerative Medicine; 1: Mesenchymal Stem Cell Expansion for Therapeutic Application; Introduction; Human MSC in Clinical Applications; In Vivo Microenvironment of Human MSC; Hypoxic Expansion of Human MSC; Extracellular Matrix for Human MSC Expansion; Three Dimensional MSC Culture; Bioreactors for MSC Expansion; Other Considerations in Ex Vivo MSC Expansion; References; 2: Role of Induced Pluripotent Stem Cells in Regenerative Medicine; Introduction
Induced Pluripotent Stem CellsAdvances in Reprogramming Techniques; Applications in Regenerative Medicine; Ectoderm Derivatives from iPS Cells; Mesoderm Derivatives from iPS Cells; Endoderm Derivatives from iPS Cells; Conclusion; References; 3: Sulforaphane as New Therapeutic Agent for Targeting of Cancer Stem Cells with Focus to Prostate and Pancreatic Cancer; Introduction; Mechanisms of Anti-carcinogenic Activity of Sulforaphane; Epidemiological Studies Point to Targeting of Cancer Stem Cells by Glucosinolates from Crucifers
Experimental Studies Support Targeting of Cancer Stem Cells by SulforaphaneReferences; 4: Technology Platforms for Heart Regenerative Therapy Using Pluripotent Stem Cells; Introduction; Learning from Natural Heart Regeneration in Zebrafish and Newt; Technical Platforms for the Realization of Human Heart Regenerative Therapy; Autogeneic Feeder Cells for PSCs; Mass Production of PSCs; Purification of Cardiomyocytes by the Mitochondrial Method; Purification of PSCs-Derived Cardiomyocytes; No Teratoma Formation; Mass Purification Strategies for Human Therapy
Efficient Engraftment of Cardiomyocyte-Balls by Re-aggregationFuture Directions; Clinical-Grade Human iPSC Derivation and Maintenance Techniques; Functional Integration of Graft Cardiomyocytes into Host Myocardium; How to Replace the Infarcted Region with New Myocardium?; References; 5: Myocardial Regeneration of Adipose Tissue-Derived Stem Cells: Differentiation, Paracrine, Fusion Mechanisms; Introduction; Characteristics of ASCs; Cardiac Repair Potential in Animal Models of MI; Survival of Transplanted ASCs in Injured Hearts; Mechanisms of ASC-Mediated Myocardial Regeneration
Differentiation of ASCs into Cardiomyocytes and Vascular CellsFusion Potential; Paracrine Effect of ASCs in Myocardial Regeneration; Clinical Trials; Safety Issues; Future Studies; References; 6: Mobilization of Pluripotent Stem Cells in Patients with Myocardial Ischemia: From the Bench to Bedside; Introduction; Structural and Molecular Characteristics of BM-Derived Pluripotent Stem Cells; Evidence of Mobilization of BM-Derived Pluripotent Stem Cells in Myocardial Ischemia in Animal Models and Humans; The Role of BM-Derived Stem Cell Transplantation in Myocardial Repair
Therapeutic Mobilization of BM-Derived Stem Cells in Myocardial Regeneration
Includes bibliographical references and index.
This seventh volume in the Springer's landmark series of edited books discusses one of the most important subjects in contemporary medicine and scientific endeavors. The volume presents a staggering range of research into medical applications of stem cells and cancer stem cells. While stem cells are essential for normal life of multicellular organisms, including humans, cancer stem cells are a morbid entity having a robust resistance to therapies including conventional chemotherapy and radiotherapy. This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.
Cancer research.
Oncology  .
Stem cells.
Neurobiology.
Blood transfusion.
Medicine.
Cancer Research.
Oncology.
Stem Cells.
Neurobiology.
Blood Transfusion Medicine.
Biomedicine, general.