The Coronin Family of Proteins [electronic resource] /
Clemen, Christoph S.editor.
Eichinger, Ludwig.editor.
Rybakin, Vasily.editor.
The coronins, first described in Dictyostelium discoideum in 1991, have been detected in all eukaryotes except plants. They belong to the superfamily of WD40-repeat proteins and represent a large family of proteins, which are often involved in cytoskeletal functions. Phylogenetic studies clearly distinguish 12 subfamilies of which six exclusively occur in vertebrates. In the present book we have made a sincere attempt to provide a comprehensive overview on all aspects of coronin proteins including history, structure, subcellular localization and function in different organisms. In addition, we
Description based upon print version of record.
The coronins, first described in Dictyostelium discoideum in 1991, have been detected in all eukaryotes except plants. They belong to the superfamily of WD40-repeat proteins and represent a large family of proteins, which are often involved in cytoskeletal functions. Phylogenetic studies clearly distinguish 12 subfamilies of which six exclusively occur in vertebrates. In the present book we have made a sincere attempt to provide a comprehensive overview on all aspects of coronin proteins including history, structure, subcellular localization and function in different organisms. In addition, we
Includes bibliographical references and index.
The Coronin Family of Proteins -- The Coronin Family of Proteins -- The WD- and Kelch-Repeat Superfamilies -- Phylogenetic, Structural and Functional Relationships between WD- and Kelch-Repeat Proteins -- Diversity of WD-Repeat proteins -- History, Phylogeny and Structure -- A Brief History of the Coronin Family -- Molecular Phylogeny and Evolution of the Coronin Gene Family -- Coronin Structure and Implications -- Common and Diverse Functions -- Coronin: The Double-Edged Sword of Actin Dynamics -- Invertebrate Coronins -- Evolutionary and Functional Diversity of Coronin Proteins -- Role of Mammalian Coronin 7 in the Biosynthetic Pathway -- Clinical Relevance -- Coronin 1 in Innate Immunity -- The Role of Mammalian Coronins in Development and Disease.
Medicine.
Biomedicine, general.