Label-free technologies for drug discovery /
Cooper, M. A.(Matthew A.)
Mayr, Lorenz.
Chichester : Wiley,
2011.
Includes bibliographical references and index.
The revolution of real-time, label-free biosensor applications / Rebecca L. Rich and David G. Myszka -- Design and implementation of vertically emitting distributed feedback lasers for biological sensing / Meng Lu ... [et al.] -- SPR screening of chemical microarrays for fragment based discovery / Thomas Neumann and Renate Sekul -- The cellkey system : a label-free cell-based assay platform for early drug discovery applications / Ryan P. McGuinness ... [et al.] -- Dynamic and label-free cell-based assays using the xcelligence system / Yama A. Abassi ... [et al.] -- Selecting the best HTS hits to move forward : ITC ligand binding characterization provides guidance / Ronan O'Brien & Richard Brown -- Incorporating transmitted light modalities into high-content analysis assays / Robert Graves -- Nonradioactive rubidium efflux assay technology for screening of ion channels / Georg C. Terstappen -- Expanding the scope of HTMS methods / Tom G. Holt ... [et al.] -- A novel multiplex SPR array for rapid screening and affinity determination of monoclonal antibodies : the proteon XPR36 label free system : kinetic screening of monoclonal antibodies / Vered Bronner, Oded Nahshol, and Tsafrir Bravman -- Biophysics/label-free assays in hit discovery and verification / Johannes Ottl -- Harnessing optical label-free on microtiter plates for lead finding from binding to phenotypes / Julio Martin -- Use of label-free detection technologies in the hit-to-lead process: surface optical detection of cellular processes / F. Stuhmeier ... [et al.] -- Cellular screening for 7TMS using label-free detection / Jeffrey C. Jerman, Jason Brown, and Magalie Rocheville -- Novartis evaluation of the ForteBio Octet RED : a versatile instrument for direct-binding experiments / Eric Martin ... [et al.] -- The pyramid approach to fragment-based biophysical screening / Glyn Williams -- Characterisation of antibodies against the active conformation of Gài1 using the SRU-BIND label free detection system / Melanie Leveridge, Chun-Wa Chung, and Trevor Wattam -- SPR based direct binding assays in drug discovery / Walter Huber -- Kinetic binding mechanisms: their contribution to an optimal therapeutic index / David C. Swinney -- ITC : more than just binding affinities / Ernesto Freire.
Drug development.