Heart Development and Regeneration [electronic resource].
Rosenthal, Nadia.
Harvey, Richard P.
Burlington : Elsevier Science,
2010.
 The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.   Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origi
Description based upon print version of record.
Front Cover; Heart Development and Regeneration; Copyright Page; Contents; List of Contributors; Foreword; Preface; Part 9 Transcriptional Circuits in Cardiac Development and Disease; Chapter 9.1. NK-2 Class Homeodomain Proteins: Conserved Regulators of Cardiogenesis; I. Introduction; II. Molecular Nature of Nkx2-5; II.A. Conserved Domains within NK-2 Genes; II.B. The TN-Domain; II.C. NK-2 Specific Domain (NK2-SD); II.D. Post-translational Modifications of Nkx2-5; III. Biochemical Interactions Between Nkx2-5 and Other Members of the Cardiac Gene Regulatory Network; III.A. GATA Factors
III.B. Foxh1III.C. T-box Proteins; III.D. Serum Response Factor; III.E. Nkx2-5 and Chromatin Remodeling Factors; IV. Nkx2-5 and Heart Disease; V. Phenotypes of Nkx2-5 Mutants in Mice; V.A. Nkx2-5 and the Patterning of the Vertebrate Heart; V.B. Nkx2-5 in the Establishment and Maintenance of Boundaries; V.C. Nkx2-5 and the Developing Ventricular Conduction System; V.D. Nkx2-5 Regulates Formation of the Endocardium; VI. Studies of Nkx2-5 in Other Vertebrate Model Systems; VII. Tinman and the Drosophila Dorsal Vessel; VIII. Regulatory Components of the Nkx2-5 Locus; IX. Conclusions; References
Chapter 9.2. GATA4 in Heart Development and DiseaseI. The GATA Family of Zinc-Finger Transcription Factors; I.A. Overview; I.B. General Properties; II. Expression of GATA Proteins in Cardiovascular Cells; II.A. The Two Subfamilies of Vertebrate GATA Proteins; II.B. GATA Proteins in the Myocardium; II.C. GATA Proteins in the Endocardium; II.D. GATA Proteins in the Outflow Tract; II.E. GATA Proteins in Other Cardiovascular Cells; III. Regulation of Cardiac GATA Factors; III.A. Regulation of Gene Expression; III.B. Regulation of Protein Activity
IV. Role of GATA Factors in Embryonic Heart DevelopmentIV.A. GATA4; IV.B. GATA5; IV.C. GATA6; V. Role of GATA Factors in Postnatal Heart Development; V.A. GATA4 and Cardiomyocyte Hypertrophy; V.B. GATA6 and Vascular Remodeling; VI. Role of GATA4 in Cardiomyocyte Survival; VII. Combinatorial Interactions of GATA Factors with Other Transcriptional Regulators; VII.A. Cell-Specific GATA Collaborators; VII.B. Inducible GATA Co-Factors; VIII. GATA Factors as Integrators and Regulators of Cell Signaling in the Heart; IX. GATA4 and Congenital Heart Disease; X. Conclusion and Perspectives; References
Chapter 9.3. Serum Response Factor and Co-Factors, Roles in Cardiac DevelopmentI. Introduction; II. Serum Response Factor; III. Embryonic Serum Response Factor Expression is Largely Restricted to Cardiac and Skeletal Muscle Tissues; IV. Serum Response Factor Orchestrates Cardiac Myogenesis; IV.A. Myogenic Contractile Proteins are Downregulated in Serum Response Factor-Null Embryonic Stem Cells; IV.B. Serum Response Factor Directs the Expression of Many MicroRNAs; V. Serum Response Factor in Human Heart Disease
V.A. Inhibitory Serum Response Factor is Generated by Caspase 3 Cleavage in Human Heart Failure
 The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.   Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origi
Heart -- Diseases -- Treatment.
Heart -- growth & development.
Heart -- Growth.
Heart -- physiology.
Myocardium -- Regeneration.
Regeneration.
Regenerative Medicine -- methods.
Human Anatomy & Physiology
Health & Biological Sciences
Physiology