Epigenetic Epidemiology [electronic resource] /
Michels, Karin B.editor.
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance.  Epigenetics plays an  important role in shaping who we are and contributes to our prospects of health and disease.  While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components.  The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!
Description based upon print version of record.
""Epigenetic Epidemiology""; ""Contents""; ""Contributors""; ""Chapter 1: Introduction""; ""References""; ""Chapter 2: The Human Epigenome""; ""2.1 Introduction""; ""2.2 Four Interacting Systems of Epigenetic Control""; ""2.3 The Basics of DNA Methylation""; ""2.4 Shaping of the Genome by DNA Methylation""; ""2.5 Effects of the Environment on DNA Methylation""; ""2.6 The Role of Aging""; ""2.7 The Use of Surrogate Tissues""; ""2.8 Appropriate Controls""; ""2.9 Summary""; ""References""
""Chapter 3: Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology""""3.1 The Objectives of Studies in Epigenetic Epidemiology""; ""3.2 The Tissue Question""; ""3.3 Selecting the Epigenetic Mark to Study""; ""3.4 Study Designs in Epigenetic Epidemiology""; ""3.4.1 Cross-Sectional Studies""; ""3.4.2 Retrospective Case-Control Studies""; ""3.4.3 Cohort Studies""; ""3.4.4 Nested Case-Control Studies""; ""3.4.5 Intervention Studies""; ""3.4.6 Family-Based Studies""; ""3.4.7 Birth Cohorts""; ""3.4.8 Summary""
""3.5 Other Methodologic Considerations in Epigenetic Epidemiology""""3.5.1 Choice of the Study Population""; ""3.5.2 Sample Size""; ""3.5.3 Effect Modification""; ""3.5.4 Confounding""; ""3.5.5 Misclassification""; ""3.6 Evaluating and Interpreting Results of Epigenetic Epidemiology Studies""; ""References""; ""Chapter 4: Laboratory Methods in Epigenetic Epidemiology""; ""4.1 Introduction""; ""4.2 Choice of the Study Design""; ""4.2.1 Biospecimens and Materials""; ""4.2.2 Experimental Backgrounds for Epidemiologic Epigenetic Research Studies""
""4.3 Epigenetic Methods Targeting Genomic DNA: DNA Methylation and Hydroxymethylation""""4.3.1 DNA Methylation""; ""4.3.1.1 Loci Specific Analyses""; ""4.3.1.2 Global Methylation of the Genome""; ""4.3.2 DNA Hydroxymethylation""; ""4.3.3 Genome-Wide Methods""; ""4.3.4 Tips and Tricks to Develop a Methylation Assay""; ""4.4 Epigenetic Studies Involving RNA: Gene Expression""; ""4.4.1 Types of RNA""; ""4.4.2 Methods for Gene Expression""; ""4.4.2.1 Overall Gene Expression""; ""4.4.2.2 Allele-Specific Gene Expression""; "" Definition of Imprinting in Relation to Expression""
"" Selection for Informative Individuals"""" Methods for Detection of Allele-Specific (Parent of Origin) Expression""; ""4.4.3 Tips and Tricks to Consider for Expression Analyses""; ""4.5 Epigenetic Studies Targeting Chromatin""; ""4.5.1 Nucleosome Occupancy""; ""4.5.2 Histones Modifications""; ""4.5.3 Chromatin Conformation""; ""4.6 Recommendation for the Method Section in Communications and Publications""; ""4.7 Conclusion and Perspective""; ""References""; ""Chapter 5: Biostatistical Methods in Epigenetic Epidemiology""; ""5.1 Introduction""
""5.2 General Statistical Considerations in Analyzing Epigenetic Data""
Includes bibliographical references and index.
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance.  Epigenetics plays an  important role in shaping who we are and contributes to our prospects of health and disease.  While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components.  The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!
Cancer research.
Epidemiology.
Human genetics.
Cancer Research.
Epidemiology.
Human Genetics.