The Metabolic Syndrome [electronic resource] : Pharmacology and Clinical Aspects /
Beck-Nielsen, Henning.editor.
Metabolic syndrome is a common syndrome affecting about 20% of the adult population in Europe, and the prevalence is likely similar in other industrialised countries worldwide. It is mainly caused by the western lifestyle, which tends to produce abdominal obesity, but a genetic predisposition also plays a part. This syndrome, which is linked to leisure lifestyles and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are essential. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in daily practice.
The MetabolicSyndrome; Pharmacology andClinical Aspects; Contents; Abbreviations; 1: Introduction and Definition of the Metabolic Syndrome; 1.1 Introduction; 1.2 History; 1.3 Dysmetabolism; 1.4 Definition and Diagnosis; References; 2: Epidemiology of the Metabolic Syndrome; 2.1 Introduction; 2.2 Epidemiology of the Metabolic Syndrome; 2.2.1 Regional Variation in the Metabolic Syndrome; 2.2.2 Ageing and the Metabolic Syndrome; 2.2.3 Gender and the Metabolic Syndrome; 2.3 Consequences of the Metabolic Syndrome; 2.3.1 Prediction of Diabetes by the Metabolic Syndrome
2.3.2 Prediction of CVD by the Metabolic Syndrome2.4 The Future of the Metabolic Syndrome in Epidemiology, Risk Prediction and Clinical Practice; References; 3: Pathophysiology of the Metabolic Syndrome; 3.1 Introduction; 3.2 Clinical Phenotype and Pathophysiology; 3.2.1 Obesity and Disorders of Adipose Tissue; 3.2.2 Insulin Resistance; 3.2.3 Metabolic Flexibility; 3.2.4 Blood Pressure; 3.2.5 Lipids; 3.3 Genetic and Environmental Contributors; 3.3.1 Environment; 3.3.1.1 Physical Inactivity; 3.3.1.2 Nutrition; 3.3.1.3 Diurnal Rhythms; 3.3.2 Genetics, Epigenetics and Early Developmental Biology
3.3.2.1 Genetics3.4 Epigenetics and Early Developmental Biology; 3.5 Gut Microbiota and the Metagenome; 3.6 Underlying Mechanisms; 3.6.1 Intracellular Lipid Accumulation and Insulin Resistance (Muscle, Liver, Pancreas, Brain); 3.6.2 Mitochondrial Function; 3.6.3 Inflammation; 3.6.4 Amino Acid Metabolism; References; 4: The Metabolic Syndrome and Cardiovascular Disease; 4.1 Association Between Metabolic Syndrome and CVD in the Population; 4.2 CVD and Metabolic Syndrome in Patients with Abnormal Glucose Tolerance; 4.3 Metabolic Syndrome and Related Cardiovascular Risk Factors
4.4 Common Soil for the Metabolic Syndrome and CVD?4.5 Metabolic Syndrome as Guide for Patient-Centred Treatment; References; 5: The Metabolic Syndrome and Cancer; 5.1 Epidemiology; 5.2 Pathophysiology; 5.3 Cancer Risk and Medical Treatment of the Metabolic Syndrome; 5.4 Treatment of the Metabolic Syndrome and Cancer Risk Reduction; References; 6: Lifestyle Intervention: Prevention of Complications to the Metabolic Syndrome; 6.1 The Metabolic Syndrome and the Risk of Type 2 Diabetes and Cardiovascular Disease; 6.2 Management of the Metabolic Syndrome
6.3 Dietary Considerations in the Prevention and Treatment of the Metabolic Syndrome6.3.1 Dietary Fat Intake; 6.3.2 Carbohydrate Intake; 6.3.3 Dietary Patterns; 6.3.4 Dietary Recommendations for the Treatment of the Metabolic Syndrome; 6.4 Physical Activity and the Metabolic Syndrome; 6.4.1 Leisure Time Physical Activity; 6.4.2 Resistance Training; 6.4.3 Sedentary Lifestyle; 6.4.4 Exercise Recommendation for the Prevention of Type 2 Diabetes and for the Treatment of the Metabolic Syndrome; 6.5 Lifestyle Trials in Type 2 Diabetes Prevention; 6.5.1 Finnish Diabetes Prevention Study
6.5.2 Diabetes Prevention Program in the USA
Includes index.
Metabolic syndrome is a common syndrome affecting about 20% of the adult population in Europe, and the prevalence is likely similar in other industrialised countries worldwide. It is mainly caused by the western lifestyle, which tends to produce abdominal obesity, but a genetic predisposition also plays a part. This syndrome, which is linked to leisure lifestyles and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are essential. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in daily practice.
Metabolic diseases.
Pharmacology.
Endocrinology .
Diabetes.
Metabolic Diseases.
Pharmacology/Toxicology.
Endocrinology.
Diabetes.