Multichain Immune Recognition Receptor Signaling [electronic resource] : From Spatiotemporal Organization to Human Disease /
Weiss, David W.,1927-
Sigalov, Alexander.editor.
Shows that the structural similarity of the Multichain Immune Recognition Receptors (MIRRs) determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. This book provides the basis for existing and future therapeutic strategies targeting MIRRs.
Description based upon print version of record.
Shows that the structural similarity of the Multichain Immune Recognition Receptors (MIRRs) determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. This book provides the basis for existing and future therapeutic strategies targeting MIRRs.
Includes bibliographical references and index.
MIRRs: Structure and Physiological Function -- T-Cell Receptor -- B-Cell Receptor -- Fc Receptors -- Natural Killer Cell Receptors -- Platelet Glycoprotein VI -- MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize -- Clustering Models -- Segregation Models -- Kinetic Proofreading Model -- Serial Triggering Model -- Conformational Model -- Permissive Geometry Model -- Signaling Chain Homooligomerization (SCHOOL) Model -- Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses -- Visualization of Protein Interactions in Living Cells -- MIRR Signaling and Therapy of Immune Disorders -- Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences -- Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides -- Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer -- Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease -- MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines -- SCHOOL Model and New Targeting Strategies -- Immune Receptor Signaling, Aging and Autoimmunity -- Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment.
Oncology  .
Medicine.
Life sciences.
Oncology.
Biomedicine, general.
Life Sciences, general.
Advances in experimental medicine and biology