Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists /
Copeland, Robert Allen.
Hoboken, N.J. : Wiley-Interscience,
C2005.
Includes bibliographical references and index.
Why enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1.  Kinetics if biochemical reactions. -- Appendix 2.  Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3.  Serial dilution schemes.
Enzyme inhibitors
Drugs
Enzyme inhibitors