Caveolins and Caveolae [electronic resource] : Roles in Signaling and Disease Mechanisms /
Jasmin, Jean-François.editor.
Frank, Philippe.editor.
Lisanti, Michael P.editor.
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.
Description based upon print version of record.
Includes bibliographical references and index.
Lipid Rafts, Caveolae and GPI‑Linked Proteins -- Caveolae and the Regulation of Endocytosis -- Caveolin‑1: Role in Cell Signaling -- Regulation of eNOS in Caveolae -- Recent Developments in the Interactions Between Caveolin and Pathogens -- Caveolin‑1 and Breast Cancer: A New Clinical Perspective -- Caveolin‑1 and Prostate Cancer Progression -- Caveolins and Caveolae, Roles in Insulin Signalling and Diabetes -- Atherosclerosis, Caveolae and Caveolin‑1 -- Caveolins and Heart Diseases --  Caveolins and Lung Function.
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.
Medicine.
Biomedicine, general.

Advances in Experimental Medicine and Biology