Histopathology of Preclinical Toxicity Studies [electronic resource] : Interpretation and Relevance in Drug Safety Evaluation
Greaves, Peter.
Burlington : Elsevier Science,
2011.
The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essentia
Description based upon print version of record.
Front Cover; Histopathology of Preclinical Toxicity Studies; Copyright Page; Contents; 1. Introduction; Pathology and the safety assessment of new medicines; Veterinary medicines; Toxicological screening; Carcinogenesis assessment; Comparative pathology; Techniques in pathology; Reporting of pathology findings; The following chapters; References; 2. Integumentary System; Skin and Subcutaneous Tissue; Non-neoplastic changes; Spontaneous inflammation and necrosis; Skin inflammation induced by topical administration; Inflammation and ulceration induced by systemic drug administration
Skin - changes in pigmentation, hyperpigmentation and hypopigmentationEpidermal atrophy; Alopecia; Increased hair growth; Changes in sebaceous glands; Epidermal hyperplasia; Induced subcutaneous inflammation; Granuloma and granulomatous inflammation; Adipose tissue inflammation, fat necrosis and steatitis; Other changes in adipose tissue; Extramedullary hematopoiesis; Elastosis; Amyloid; Mineralization; Neoplasms of epidermal origin; Classification and diagnosis of skin tumors; Squamous papilloma; Sebaceous adenoma; Tumors showing hair follicle differentiation; Carcinoma
Neoplasms of the melanogenic systemNevi (benign melanoma); Malignant melanoma; Subcutaneous (soft tissue or mesenchymal) neoplasms; Induced subcutaneous soft tissue neoplasms: injected and implanted substances; Induced subcutaneous soft tissue neoplasms: drugs administered systemically; Classification; Histogenesis; Fibroma; Fibrosarcoma; Pleomorphic fibrosarcoma, pleomorphic sarcoma, malignant fibrohistiocytoma; Malignant histiocytoma, histiocytic sarcoma; Canine cutaneous histiocytoma; Mast cell tumor, mastocytoma; Lipoma; Hibernoma (brown fat tumor); Liposarcoma; Rhabdomyosarcoma
LeiomyomaLeiomyosarcoma; Proliferative vascular changes; Congestion; Angiectasis; Angiomatous Hyperplasia; Hemangioma (angioma, hemangioendothelioma, hemangiopericytoma); Hemangiosarcoma (angiosarcoma); Miscellaneous soft tissue neoplasms; References; 3. Mammary Gland; Endocrinology; Anatomy; Cytochemistry and immunocytochemistry; Non-neoplastic changes; Inflammation; Atrophy; Mammary gland enlargement; Cysts, cystic change, cystic degeneration, milk cysts, galactocele, duct ectasia; Hyperplasia; Duct hyperplasia; Lobular hyperplasia; Mammary neoplasia; Classification; Fibroadenoma; Adenoma
FibromaIntraduct papilloma; Carcinoma; Mammary carcinoma - rat; Mammary carcinoma - mouse; Mammary carcinoma - hamster; Mammary carcinoma - dog; Mammary carcinoma - primates; Factors affecting prevalence of mammary neoplasms in experimental studies; Mammary tumors and safety assessment; References; 4. Hemopoietic and Lymphatic Systems; Blood and Bone Marrow; Humans; Laboratory animals; Red blood cell values; Platelet values; White blood cell and differential counts; Bone marrow; Lymphoid System; Immunotoxicology; Immunocytochemistry of lymphoreticular cells; Lymph Nodes
Atrophy, hypoplasia, aplasia, lymphocyte depletion, unstimulated pattern
The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essentia
Drugs - Toxicity testing.
Drugs -- Toxicology.
Laboratory animals - Histopathology.
Laboratory animals -- Histopathology.
Toxicity testing.
Drugs
Laboratory animals
Medicine
Drug Discovery
Animal Population Groups
Evaluation Studies as Topic
Anatomy
Investigative Techniques
Animals
Biological Science Disciplines
Health Occupations
Natural Science Disciplines
Occupations
Eukaryota
Drug Evaluation, Preclinical
Pathology
Animals, Laboratory
Histology
Public Health
Health & Biological Sciences
Toxicology & Public Health