Allergens and Respiratory Pollutants [electronic resource] : The Role Of Innate Immunity
Williams, M A.
Williams, Marc A.Contributor
Burlington : Elsevier Science,
2011.
Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health e
Description based upon print version of record.
Cover; Wood head Publishing Seriesin Biomedicine; Allergens and respiratory pollutants: The role of innate immunity; Copyright; Contents; List of illustrations; Figures; Tables; Editor's note; About the editor and contributors; 1 An introduction to allergic inflammation and the innate immune sensing of dangerous ambient pollutants by the dendritic cell; 1.1 Introduction; 1.2 The mononuclear phagocyte system: key players in innate immunity; 1.3 The enigmatic dendritic cell: the Janus face of immunity; 1.4 Atopic inflammation; 1.5 The hygiene hypothesis
1.6 Pulmonary dendritic cells sense the enemy within1.7 Concluding remarks; References; 2 Asthma: primary immunomodulatory pathways; 2.1 Introduction; 2.2 Receptors of the innate immune system and asthma; 2.3 Additional immunoregulatory pathways; 2.4 Bioinformatics/systems biology; 2.5 The future; Acknowledgments; References; 3 Environmental lung injury and pattern recognition receptors; 3.1 Introduction; 3.2 Toll-like receptor 4 signaling; 3.3 Bacterial endotoxin contributes to environmental airways disease; 3.4 Microbial contamination of aerosolized biomass
3.5 The role of toll-like receptors in sterile lung injury3.6 Toll-like receptor 4 and other human lung diseases; 3.7 Allergic airways disease and toll-like receptors; 3.8 Transplantation and pattern recognition receptors; 3.9 Environmental co-exposures and pattern recognition receptors; 3.10 Conclusion; Acknowledgements; References; 4 Asthma exacerbations: a paradigm of synergy between allergens, pollutants and viruses; 4.1 Introduction; 4.2 Immunopathology of controlled asthma; 4.3 Adaptive immunity, from atopy to asthma; 4.4 Innate immunity from atopy to asthma
4.5 Immunopathology of exacerbations4.6 Immunopathology according to triggering factors; 4.7 Concluding remarks: at least two synergistic inflammatory processes are required to induce asthma exacerbations; References; 5 Bronchial hyperresponsiveness and lung inflammation induced by allergic immune response and oxidative stress: role of innate and adaptiveimmune responses; 5.1 Introduction; 5.2 Airway responses to allergens; 5.3 Ozone and lung disease; 5.4 Conclusions; Acknowledgements; References; 6 Effects of air pollutants on allergic sensitization through the airway; 6.1 Introduction
6.2 Adjuvants6.3 Dendritic cells; 6.4 Immunotolerance to inhaled antigens; 6.5 Animal models of air pollution-enhanced allergic sensitization; 6.6 Mechanisms of air pollution-enhanced allergic sensitization; References; 7 Particulate matter and oxidative stress: dangerous partners in inflammation, vascular dysfunction and innate immunity; 7.1 Introduction; 7.2 Role of ultrafine particles; 7.3 Dendritic cells as key environmental sensors; 7.4 Dangerous properties of PM; 7.5 Response to inhaled PM; 7.6 Concluding remarks; References
8 Diesel exhaust particles and the airway epithelial cell-dendritic cell interface in the control of immune homeostasis
Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health e
Allergens.
Ecotoxicology.
Environmental toxicology.
Immunity, Innate.
Lung Diseases -- immunology.
Lungs -- Diseases.
Natural immunity.
Natural immunity
Allergens
Environmental toxicology
Lungs
Toxicology
Ecology
Immunity
Respiratory Tract Diseases
Antigens
Earth Sciences
Biological Factors
Diseases
Pharmacology
Immune System Phenomena
Biology
Biological Science Disciplines
Health Occupations
Natural Science Disciplines
Ecotoxicology
Lung Diseases
Allergens
Immunity, Innate
Biology
Health & Biological Sciences
Microbiology & Immunology