Signal transduction /
Gomperts, B. D.
Tatham, Peter E. R.
Kramer, Ijsbrand M.
Amsterdam ; Boston : Elsevier/Academic Press,
c2009.
"A reference on cellular-signalling processes, Signal Transduction second edition details the sources, key observations, and experiments that set the scene for recent and current scientific endeavour. Beginning with a historical overview, this book discusses how the concept of chemical messengers arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, and growth factors." "The book further examines more complex signalling cascades, emanating from classic receptors, as well as adhesion molecules, involved in processes such as vision, smell, inflammation, innate and adaptive immunity, glucose homeostasis, cell-fated decisions, cell differentiation, and cell transformation. This revision concludes with a discourse on the targeting of signal-transduction cascades in the treatment of cancer and the structure of protein domains key to the assembly of signalling complexes."--BOOK JACKET.
Includes bibliographical references and index.
Prologue: Signal Transduction, origins and ancestors  -- First messengers  -- Receptors  -- GTP-binding proteins and signal transduction  -- Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C  -- The regulation of visual transduction and olfaction  -- Intracellular calcium  -- Calcium effectors  -- Phosphorylation and dephosphorylation: protein kinases A and C  -- Nuclear receptors  -- Growth Factors: Setting the framework  -- Signalling pathways operated by receptor protein tyrosine kinases  -- Signal transduction to and from adhesion molecules  -- Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt  -- Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation  -- Traffic of white blood cells  -- Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT  -- Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor  -- Protein Kinase C revisited  -- Signalling through receptor serine/threonine kinases  -- Protein dephosphorylation and protein phosphorylation  -- Notch  -- Targeting transduction pathways for research and medical intervention  -- Protein domains and signal transduction.
"A reference on cellular-signalling processes, Signal Transduction second edition details the sources, key observations, and experiments that set the scene for recent and current scientific endeavour. Beginning with a historical overview, this book discusses how the concept of chemical messengers arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, and growth factors." "The book further examines more complex signalling cascades, emanating from classic receptors, as well as adhesion molecules, involved in processes such as vision, smell, inflammation, innate and adaptive immunity, glucose homeostasis, cell-fated decisions, cell differentiation, and cell transformation. This revision concludes with a discourse on the targeting of signal-transduction cascades in the treatment of cancer and the structure of protein domains key to the assembly of signalling complexes."--BOOK JACKET.
Signal Transduction.
Cellular signal transduction.