Tumor Models in Cancer Research [electronic resource] /
Teicher, Beverly A.editor.
Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.
Description based upon print version of record.
Tumor Models in Cancer Research; Preface; Contents; Contributors; Part I Introduction; Chapter 1: Perspectives on the History and Evolution of Tumor Models; Part II Transplantable Syngeneic Rodent Tumors; Chapter 2: Murine L1210 and P388 Leukemias; Chapter 3: Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice; Chapter 4: B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model; Part III Human Tumor Xenografts; Chapter 5: Human Tumor Xenograft Efficacy Models
Chapter 6: Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real TimeChapter 7: Patient-Derived Tumor Models and Explants; Chapter 8: The Pediatric Preclinical Testing Program; Chapter 9: Imaging Efficacy in Tumor Models; Part IV Carcinogen-Induced Tumors; Chapter 10: Mammary Cancer in Rats; Part V Disease and Target-Specific Models; Chapter 11: Animal Models of Melanoma; Chapter 12: Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic Approac; Chapter 13: Animal Models of Mesothelioma
Chapter 14: The Use of Mouse Models to Study Leukemia/Lymphoma and Assess Therapeutic ApproachesChapter 15: Spontaneous Companion Animal (Pet) Cancers; Part VI Genetically Engineered Mouse Models of Cancer; Chapter 16: Genetically Engineered Mouse Models of Pancreatic Ductal Adenocarcinoma; Chapter 17: Transgenic Adenocarcinoma of the Mouse Prostate: A Validated Model for the Identification and Characterization of M; Chapter 18: The Utility of Transgenic Mouse Models for Cancer Prevention Research; Part VII Metastasis Models
Chapter 19: Models for Evaluation of Targeted Therapies of Invasive and Metastatic DiseasePart VIII Normal Tissue Response Models; Chapter 20: Animal Models of Toxicities Caused by Anti-Neoplastic Therapy; Chapter 21: Bone Marrow as a Critical Normal Tissuethat Limits Drug Dose/Exposure in Preclinical Models and the Clinic1; Chapter 22: Anesthetic Considerations for the Study of Murine Tumor Models; Part IX Experimental Methods and Endpoints; Chapter 23: Preclinical Tumor Response End Points; Chapter 24: Tumor Cell Survival; Chapter 25: Apoptosis In Vivo
Chapter 26: Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function and TherapeutiIndex
Includes bibliographical references and index.
Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.
Cancer research.
Pharmacology.
Cancer Research.
Pharmacology/Toxicology.
Cancer Drug Discovery and Development