Investigative Electrocardiography in Epidemiological Studies and Clinical Trials [electronic resource] /
Rautaharju, Pentti.author.
Rautaharju, Farida.author.
Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs. Investigative Electrocardiography in Epidemiological Studies and Clinical Trials reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents. With emphasis on providing international coverage of the topic, the well-respected authors present key information on ECG procedures, epidemiology, problem areas, mortality and morbidity risk. These topics are of particular interest to electrocardiologists, investigators in active ECG research in medical clinics participating in clinical trials, epidemiologists, cardiologists, pharmaceutical companies and regulatory bodies.
Description based upon print version of record.
Includes bibliographical references and index.
Investigative Electrocardiography in Epidemiological Studies and Clinical Trials -- Cardiac Excitation and Repolarization -- Electrocardiographic Lead Systems -- Normal and Arrhythmogenic Ionic Channel Mechanism -- Heart Rate and Heart Rate Variability -- Methodological Considerations in Heart Rate Variability Analysis -- Supraventricular Dysrhythmias -- Ectopic Ventricular Activity -- Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs -- Left Ventricular Hypertrophy -- Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage -- Prolonged Ventricular Excitation -- Old Myocardial Infarction -- Attributable Risk -- Primary Repolarization Abnormalities -- Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements -- QT Prolongation and QT Dispersion — a Critical Evaluation -- Normal ECG Standards for Adults by Gender, Age, and Ethnicity -- ECG Intervals: Tables -- ECG Wave Amplitudes*: Tables -- ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables -- ECG Amplitudes at 10ms Intervals: Tables -- Repolarization Waveform Vectors: Tables.
Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs. Investigative Electrocardiography in Epidemiological Studies and Clinical Trials reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents. With emphasis on providing international coverage of the topic, the well-respected authors present key information on ECG procedures, epidemiology, problem areas, mortality and morbidity risk. These topics are of particular interest to electrocardiologists, investigators in active ECG research in medical clinics participating in clinical trials, epidemiologists, cardiologists, pharmaceutical companies and regulatory bodies.
Cardiology.
Cardiac surgery.
Vascular surgery.
Epidemiology.
Internal medicine.
Cardiology.
Cardiac Surgery.
Vascular Surgery.
Epidemiology.
Internal Medicine.