현창기

서명 = **현창기**(玄昌騎, Chang-Kee Hyun, 1963년- )는 대한민국의 교수이다. 한동대학교 생명과학부 교수로 있으며 대사생화학 분야를 전공하고 있다. 관심 연구분야는 인슐린 저항성, 대사이상 지방간질환 등의 발병 분자기전에 기반한 치료제 개발, 대사질환과 염증성 장질환 간의 연계 기전, 장내균총 교란 관련 발병 및 치료 기전 등이다. 또한 기독교 세계관 및 기원과학 분야에도 관심을 두고 무신론적 진화론에 대한 비판적 고찰과 유신론적 과학이론의 대안적 제안 등에 대한 연구와 집필 활동을 수행해왔다.
# 학력
* 서울대학교 학사 * KAIST 박사
# 경력
* 1995~현재 한동대학교 생명과학부 교수
# 논문

## 해외학술지
* Kim B, Ronaldo R, Kweon BN, Yoon S, Park Y, Baek JH, Lee JM, Hyun CK. Mesenchymal Stem Cell-Derived Exosomes Attenuate Hepatic Steatosis and Insulin Resistance in Diet-Induced Obese Mice by Activating the FGF21-Adiponectin Axis. International Journal of Molecular Sciences 27(19), 10447 (2024) DOI: 10.3390/ijms251910447. * Lee C, Kim S, Kim B, Holzapfel WH, Hyun CK. Disturbance of lipid metabolism in germ-free mice transplanted with gut microbiota of DSS-induced colitis mice. PLoS One 18(2), e0280850 (2023) DOI: 10.1371/journal.pone.0280850 * Hyun CK. Molecular and Pathophysiological Links between Metabolic Disorders and Inflammatory Bowel Diseases. International Journal of Molecular Sciences 22(17), 9139 (2021) DOI: 10.3390/ijms22179139. * Kwon J, Lee C, Heo S, Kim B, Hyun CK. DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice. Scientific Reports 11(1), 5283 (2021) DOI: 10.1038/s41598-021-84761-1 * Kim B, Hyun CK. B-cell-activating factor depletion ameliorates aging-dependent insulin resistance via enhancement of thermogenesis in adipose tissues. International Journal of Molecular Sciences 21(14), 5121 (2020) DOI: 10.3390/ijms21145121 * Kwon J, Kim B, Lee C, Joung H, Kim BK, Choi IS, Hyun CK. Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice. PLoS One 15(2), e0228932 (2020) DOI: 10.1371/journal.pone.0228932 * Ji Y et al., Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model. Scientific Reports 9(1), 6821 (2019) DOI: 10.1038/s41598-019-43092-y * Kim KD et al., Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK. Nutrition, Metabolism and Cardiovascular Diseases 29(4), 409-420 (2019) DOI: 10.1016/j.numecd.2018.12.001 * Kim B, Kwon J, Kim MS, Park H, Ji Y, Holzapfel W, Hyun CK. Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice. PLoS One 13(12), e0210120 (2018) DOI: 10.1371/journal.pone.0210120 * Jung HY et al., Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice. Diabetes, Obesity and Metabolism 20(7), 1688-1701 (2018) DOI: 10.1111/dom.13284 * Kim MS et al., Long-term fermented soybean paste improves metabolic parameters associated with non-alcoholic fatty liver disease and insulin resistance in high-fat diet-induced obese mice. Biochemical and Biophysical Research Communications 495, 1744-1751 (2018) DOI: 10.1016/j.bbrc.2017.12.003 * Kim B et al., Syringin attenuates insulin resistance via adiponectin-mediated suppression of low-grade chronic inflammation and ER stress in high-fat diet-fed mice. Biochemical and Biophysical Research Communications 488, 40-45 (2017) DOI: 10.1016/j.bbrc.2017.05.003 * Park S et al., Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model. Applied Microbiology and Biotechnology 101, 1605-1614 (2017) DOI: 10.1007/s00253-016-7953-2 * Kim B, Hyun CK. Gender-Specific Mechanisms Underlying the Amelioration of High-Fat Diet-Induced Glucose Intolerance in B-Cell-Activating Factor Deficient Mice. PLoS One 11(11), e0166225 (2016) DOI: 10.1371/journal.pone.0166225 * Kim B et al., Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice. Biochemical and Biophysical Research Communications 473, 530-536 (2016) DOI: 10.1016/j.bbrc.2016.03.107 * Kim B et al., B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function. Biochemical and Biophysical Research Communications 464, 1171-1177 (2015) DOI: 10.1016/j.bbrc.2015.07.099 * Park KY et al., Lactobacillus rhamnosus GG improves glucose tolerance through alleviating ER stress and suppressing macrophage activation in db/db mice. Journal of Clinical Biochemistry and Nutrition 56(3), 240-246 (2015) * Park KY et al., Lactobacillus rhamnosus GG reverses insulin resistance but does not block its onset in diet-induced obese mice. Journal of Microbiology and Biotechnology 25(5), 753-757 (2015) * Jung-Han Lee, Chang-Kee Hyun, Insulin-sensitizing and beneficial lipid-metabolic effects of water-soluble melanin complex extracted from Inonotus obliquus. Phytotherapy Research 28(9), 1320-1328 (2014) * Sun-Woo Kim, Kun-Young Park, Bobae Kim, Eunha Kim, Chang-Kee Hyun. Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production. Biochemical and Biophysical Research Communications 431, 258-263 (2013) * Eunha Kim, Jung-Han Lee, James M. Ntambi, Chang-Kee Hyun, Inhibition of stearoyl-CoA desaturase1 activates AMPK and exhibits beneficial lipid metabolic effects in vitro. European Journal of Pharmacology 672, 38-44 (2011) * Eun-do Kim, Eunha Kim, Jung-Han Lee, James Ntambi, Chang-Kee Hyun, Gly-Ala-Gly-Val-Gly-Tyr, a novel synthetic peptide, improves glucose transport and exerts beneficial lipid metabolic effects in 3T3-L1 adipoctyes. European Journal of Pharmacology 650, 479-485 (2011) * Chang-Kee Hyun, Eun-Do Kim, Matthew T. Flowers, Xueqing Liu, Eunha Kim, Maggie Strable, and James M. Ntambi, Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochemical and Biophysical Research Communications 399(4), 480-486 (2010) * Kim ED et al., Fibroin-derived peptides stimulate glucose transport in normal and insulin-resistant 3T3-L1 adipocytes. Biological and Pharmaceutical Bulletin 32(3), 427-433 (2009) * Kim SH et al., Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes. Biological and Pharmaceutical Bulletin 30(11), 2120-2125 (2007) * Choi BH et al., Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Experimental and Molecular Medicine 38, 599-605 (2006) * Park KJ et al., Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells. Pharmacological Research 52, 346-352 (2005) * Kim, IY, Hyun CK, Comparative evaluation of the alkaline comet assay with the micronucleus test for genotoxicity monitoring using aquatic organisms. Ecotoxicology and Environmental Safety, 64(3), 288-297(2006) * Hyun CK, Kim IY, Frost SC, Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes. Journal of Nutrition 134, 3257-3263 (2004) * Jin HH et al., Detection of DNA damage in carp using single-cell gel electrophoresis assay for genotoxicity monitoring. Journal of Microbiology and Biotechnology 14(2), 268-275 (2004) * Park KJ et al., Antigenotoxicity of the peptides produced from silk fibroin. Process Biochemistry, 38, 411-418 (2002) * Park KJ, Hyun CK, Production of antigenotoxic peptides from bovine blood plasma proteins. Enzyme and Microbial Technology 30(5), 633-638 (2002) * Hyun CK, Shin HK, Utilization of bovine blood plasma proteins for the production of angiotensin I converting enzyme inhibitory peptides. Process Biochemistry 36, 65-71 (2000) * Park JH et al., Cytotoxic effects of the components in heat-treated mistletoe (Viscum album). Cancer Letters 139, 207-213 (1999) * Park JH et al., Cytotoxicity of heat-treated Korean mistletoe. Cancer Letters 126(1), 43-48 (1998) * Hyun CK, Shin HK, Utilization of bovine blood proteins produced from slaughterhouse for the economic production of probiotics. Journal of Bioscience and Bioengineering 86(1), 34-37 (1998) * Hyun, C.K., E. Tamiya, T. Takeuchi, I. Karube and N. Inoue, A novel BOD sensor based on bacterial luminescence. Biotechnology and Bioengineering 41(11), 1107-1111 (1993) * Hyun, C.K., J.H. Kim and D.D.Y. Ryu, Enhancement effect of polyethylene glycol on enzymatic synthesis of cephalexin. Biotechnology and Bioengineering 41(6), 654-658 (1993) * Hyun, C.K., J.H. Choi, J.H. Kim and D.D.Y. Ryu, Enhancement effect of water activity on enzymatic synthesis of cephalexin. Biotechnology and Bioengineering 42(7), 800-806 (1993) * Hyun, C.K., J.H. Kim and Y.J. Kim, Effect of water activity on enzymatic synthesis of cephalexin. Biotechnology Letters 11(8), 537-540 (1989) * Oh DK, Hyun CK, Kim JH, Production of penicillin in a fluidized-bed bioreactor: control of cell growth and penicillin production by phosphate limitation. Biotechnology and Bioengineering 32, 569-573 (1988) **국내학술지** * 김보배, 김민석, 현창기. 고지방식이 유도 비만 마우스에서 Inonotus obliquus의 체중 증가 억제 및 지방대사 개선 작용 (Suppression of Adiposity and Improvement of Fat Metabolism in High-fat Diet-induced Obese Mice Treated with an Inonotus obliquus Extract). 생약학회지 47(2), 172-178 (2016) * 김보배, 현창기, 고지방식이 유도 비만 마우스에서 Acanthopanax senticusus의 지방축적 억제 및 인슐린 저항성 개선 작용. 생약학회지 46, 65-71 (2015) * Kim, S. H., E. J. Shin, C. K. Hyun, 3T3-L1 지방세포에서 Phellodendri cortex의 glucose uptake 촉진 및 인슐린 저항성 개선 활성. 생약학회지 36, 291-298 (2005) * Kim, I. Y. and C. K. Hyun, Single-cell Gel Electrophoresis Assay에 의한 Spisula sachalinensis에서의 in Vivo 유전독성 평가. 한국독성학회지 20, 225-232 (2004) * Hong, S. E., K. J. Park, B. S. Suh, M. S. Do and C. K. Hyun, 실크 피브로인 산 가수분해물이 db/db mice의 지방세포 대사에 미치는 영향. 생약학회지 33(4), 313-318 (2002) * Park, K. J. and C. K. Hyun, Stimulation of Nitric Oxide Production in RAW 264.7 Macrophages by the Peptides Derived from Silk Fibroin, 한국미생물생명공학회지 30(1), 39-45 (2002) * Park, K. J., S. E. Hong, M. S. Do and C. K. Hyun, Streptozotocin 당뇨유발 쥐와 db/db 마우스에서의 피브로인 가수분해물에 의한 인슐린 분비 촉진, 생약학회지, 33(1), 22-28 (2002) * 김해홍, 김동만, 현창기, Quinone reductase 유도활성 측정에 의한 약용식물의 항암활성 검색(Induction of quinone reductase by extracts of tranditional medicinal plants). 생약학회지 32(2), 168-174 (2001) * Hyun, C. K., Applications of biosensors in environmental monitoring. 생물화공(Biochemical Engineering and Biotechnology) 8(2), 10-16 * Hyun, C. K. and H. K. Shin, Production of angiotensin I converting enzyme inhibitory peptides from bovine blood plasma proteins. 한국생물공학회지 14(5), 600-605 (1999) 외 다수
# 번역서 및 저서
* 정병갑, 정국현, 고석찬, 임헌만, 강병호, 현창기, 이명선, 정용석, 김철근, 이영섭, 장락우 공역, "MEET, DEET, GRE 준비를 위한 생화학 및 분자·세포생물학(Color Atlas of Biochemistry)", 월드사이언스, 2008년 * 현창기, 김종명, 김군도 공역, "신호전달(Signal Transduction)", 월드사이언스, 2009년 * 현창기, 도명술 공역, "위대한 설계, 그 흔적들 (Signs of Intelligence – Understanding Intelligent Design)", 새물결플러스, 2014년 * 현창기, 김기웅, 김은실, 김효정, 류현실, 정병윤, 이상찬 공저. "기독교 세계관으로 풀어보는 과학수업", DCTY (꿈을 이루는 사람들), 2014년 * 소현수, 현창기, 배성민, 김병훈 공역. "유신진화론 비판(Theistic Evolution: A Scientific, Philosophical, and Theological Critique)", 부흥과개혁사, 2019년
# 기독교 세계관 및 기원과학 분야 논문
* 현창기, 도명술, 생명복제에 대한 기독교적 고찰, 통합연구 12(1), 81-105 (1999) * 현창기, Mitochondria 및 mitochondrial ribosome의 endosymbiosis 진화가설에 대한 비판적 고찰, 통합연구 18(2), 131-154 (2005) * 현창기, 줄기세포를 이용한 난치병 치료 연구의 현황. In '줄기세포연구와 난치병 치료' 배아복제를 반대하는 과학자모임 기획, pp.77-108 (2006) * 전동규, 현창기, 초소형 분자 모터 ATP synthase에 대한 지적설계 논증, 지적설계연구회 심포지움, 2008년 2월 * 최훈, 현창기, Proopiomelanocortin - prohormone convertase 상호작용에 기초한 지적설계 논증, 지적설계연구회 심포지움 논문집, 2010년 2월 * 류현실, 현창기, 기독교 세계관에 기초한 초등과학교과 물 관련 단원의 이론적 탐색과 개발의 틀. 신앙과 학문 17(3), 115-143 (2012) * 이나연, 현창기, B 세포 성숙기작을 이용한 신다윈주의 자연선택 진화모델에 대한 비판적 고찰. 신앙과 학문 19(1), 97-115 (2014) * 김아람, 현창기, 인간 유전체 ENCODE 프로젝트와 정크 DNA의 기능성 논쟁에 대한 기원과학적 고찰. 신앙과 학문 21(3), 7-35 (2016)