NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
oligomycin sensitivity-conferring protein: one subunit of whole atpase complex of mitochondria, binding f(1) sector of atpase complex to membrane sector; see also atpase-binding protein (26,500)
oligonol: a product emanating from the oligomerization of polyphenols, typically proanthocyanidin from a variety of fruits (grapes, apples, persimmons, etc.) and contains catechin-type monomers and proanthocyanidin oligomers
oligonucleotidase: from flammulina veluptis; catalyzes exonucleolytic cleavage of oligonucleotides to yield 5'-phosphomononucleotides; also hydrolyzes nad+ to nmn & amp; formerly ec 3.1.4.19
oligonucleotide 5005: isosequential analog of 4625; oligonucleotides, antisense being a d27 term is not allowed by the system as hm
oligonucleotide 5320: a phosphorothioate oligonucleotide
oligonucleotide ENA-13: modified with 2'-o,4'-c-ethylene-bridged nucleic acids; base
oligopeptidase: from bacillus spaericus; acts on dipeptides & some tri- or tetrapeptides with ala-ala
oligopeptidase A: e. coli endopeptidase which cleaves signal peptides with minimun of 5 residues with ala or gly at recognition & cleavage sites; classified as ec 3.4.24.70
oligopeptidase B: a trypsin-like peptidase that hydrolyzes -arg-/ and -lys-/ bonds in oligopeptides, even when p1' residue is proline; homolog of prolyl endopeptidase; amino acid
oligopeptidase PepO: an oligopeptidase found in a variety of bacteria
oligopeptide permease, Bacteria: bacterial; does not act on free amino acids; takes up dipeptides & oligopeptides of up to 5 amino acids; spo0k, an abc transporter, isolated from bacillus subtilis; see also oppb protein and oppc protein
oligopeptide-binding protein, Salmonella typhimurium: periplasmic protein involved in oligopeptide transport
oligopeptide-binding protein, bacteria: the periplasmic component of the major oligopeptide transport system of enteric bacteria
oligophosphoglycerol-ATP: short phosphate-linked copolymer of d-glyceric acid & adenosine; high energy derivative located in mitochondria in rat liver & heart
oligophosphoglyceroyl-ATP 3'-phosphodiesterase: located in mitochondrial fraction of rat liver; selectively hydrolyzes the oligo cpd to monomeric units of 3-phosphoglyceroyl-gamma-triphospho-5'-adenosine
oligoporin A: triterpene glucoside from oligoporus tephroleucus
oligoporin B: triterpene glucoside from oligoporus tephroleucus
oligoporin C: triterpene glucoside from oligoporus tephroleucus
oligoribonuclease: a 3'-5' exoribonuclease in escherichia coli; copurifies with polynucleotide phosphorylase
oligosaccharide 2-O-sulfatase: hydrolyzes the 2-o-sulfate of the disaccharide 4-deoxy-2-o-sulfato-alpha-l-threo-hex-4-enopyranosyluronic acid-(1-4)-2-deoxy-2-sulfamido-6-o-sulfato-d-glucose from heparin
oligosaccharide dehydrogenase: commercial preparation from staphylococcus which catalyzes oxidation of reducing sugars such as glucose, galactose, fructose, mannose, maltose, lactose, maltotriose, maltotetraose, maltopentaose and maltohexaose
oligosaccharide-diphosphodolichol pyrophosphatase: from yeast microsomal membranes; hydrolyses the pyrophosphate bond of oligosaccharide-pyrophosphodolichol into oligosaccharide phosphates plus dolicholphosphate
oligosaccharyl sulfatase: from keyhole limpet; hydrolyzes sulfate esters in asparagine-linked oligosaccharides preferentially to 4-nitrocatechol sulfate
oligostatin C: antibiotic from streptomyces myxogenes nov. sp. sf-1130 with activity against gram-negative bacteria & with amylase inhibitory activity
oligostatin D: antibiotic from streptomyces myxogenes nov. sp. sf-1130 with activity against gram-negative bacteria & with amylase inhibitory activity; ; rn given refers to parent cpd
oligostatin E: antibiotic from streptomyces myxogenes nov. sp. sf-1130 with activity against gram-negative bacetria & with amylase inhibitory activity
oligotide: an oligodeoxyribonucleotide of mw 4-10 kda, obtained by controlled hydrolysis of dna from mammalian lungs; has cardioprotective effect
oligoxyloglucan hydrolase: from aspergillus oryzae; highly specific for xyloglucan oligosaccharides; splits off isoprimeverose disaccharide units from non-reducing end
olipudase alfa: a recombinant human acid sphingomyelinase for the treatment of acid sphingomyelinase deficiency
olitoriside: from adonis mongolica sim; rn given refers to (d-xylo)-isomer; see also erysimoside for (d-ribo)-isomer: 7082-34-0
olivacine: alkaloid with antitumor & antileukemic activity isolated from aspidosperma olivaceum; structure; rn given refers to parent cpd
olivanic acid: beta-lactam antibiotics produced by streptomyces olivaceus atcc 31365; all have carbapenum nucleus; structures in sixth source
oliveroline: rn given refers to hcl(7as-cis)-isomer
olivetolic acid cyclase, Cannabis sativa: catalyzes the cyclization of an acyl-coa to yield olivetolic acid, an intermediate in cannabinoid biosynthesis
olivine: sand of primarily magnesium iron silicate, containing low levels of free silica; suggested as a less injurious substitute for silica quartz in foundries; rn in chemline for unspecified composition: 1317-71-1
olivoretin: from streptoverticillium olivoreticuli; olivoretin a,b,c are o-methylated teleocidin b isomers; biologically inactive; ; rn given refers to olivoretin a; rn for olivoretin not available 3/85
olokizumab: targets interleukin-6 and neutralizing gp130-signaling
olsalazine: cpd with 2 salicylate molecules linked together by an azo bond
olverembatinib: inhibits bcr-abl kinase to overcome imatinb resistance
oma-2 protein, C elegans: involved in oocyte maturation; amino acid ; refseq nm_072668.5
omadacycline: demonstrated in vitro activity against a broad range of gram-positive and select gram-negative pathogens
omaezallene: bromoallene-containing chemical isolated from the red alga laurencia sp
ombitasvir: inhibits hcv ns5a protein, component of viekirax
ombuin-3-O-glucopyranoside: isolated from gynostemma pentaphyllum
omc A protein, Shewanella putrefaciens: a gene encoding a decaheme outer membrane cytochrome of shewanella putrefaciens; amino acid
omcC protein, Geobacter sulfurreducens: putative outer membrane polyheme c-type cytochrome; amino acid sequence given in first source
ome protein, Drosophila: has been sequenced; refseq nm_001144483
omega-(2-iodophenyl)pentadecanoic acid: used for scintigraphic imaging; rn given refers to 131i-labeled cpd
omega-(3-diazirinophenoxy)hexadecanoic acid: photo-sensitive
omega-(4-iodophenyl)pentadecanoic acid: imaging agent; rn given refers to parent cpd without isomeric designation
omega-(diazirinophenoxy)nonanoic acid: photoreactive indicator of localization of membrane proteins
omega-1 antigen, Schistosoma mansoni: a soluble egg antigen involved in th2 skewing
omega-3 fatty acid desaturase: catalyzes desaturation of the omega-3 carbon (3rd from free end) of c-18 fatty acids; deficiency results in accumulation of linoleic acid (18:2omega6,9) at the expense of linolenic acid (18:3omega3,6,9)
omega-5 gliadin, wheat: transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances ige reactivity in wheat-dependent, exercise-induced anaphylaxis
omega-agatoxin-Aa4b: a peptide toxin from venom of funnel web spider, agelenopsis aperta
omega-amidase: catalyzes the conversion of a monoamide of a dicarboxylic acid to a dicarboxylate & ammonia
omega-amino-ceramide: plays a second messenger in signal tranduction pathways including cell differentiation and apoptosis
omega-atracotoxin Hv2a: isolated from the australian funnel-web spider hadronyche versuta; amino acid
omega-atracotoxin-HV1: a 37-residue peptide from the venom of australian funnel web spider, hadronyche versuta; amino acid sequence given in first source
omega-conotoxin MVIID: isolated from the cone snail conus magus; amino acid sequence given in first source
omega-conotoxin PnVIA: isolated from lymnaea stagnalis; amino acid
omega-conotoxin PnVIB: isolated from lymnaea stagnalis; amino acid
omega-conotoxin SVIA: from conus striatus; ca channel-targeted paralytic peptide; amino acid sequence given in first source
omega-conotoxin SVIB: from conus striatus; ca channel-targeted paralytic peptide; lethal to mice upon ic injection; amino acid sequence given in first source
omega-conotoxin TxVII: from the venom of conus textile; amino acid sequence given in first source
omega-conotoxin-MVIIC: isolated from conus magus; amino acid sequence given in first source
omega-fluoro-9-octadecenoic acid: main fluorine-containing substance in the seeds of dichapetalum toxicarum
omega-grammotoxin SIA: a peptidergic blocker of voltage-sensitive calcium channel responses; from grammostola spatulata (tarantula spider) venom; contains a total of 36 amino acid residues with multiple disulfide bridges; amino acid sequence given in first source
omega-hydroxyleukotriene E4 dehydrogenase: liver microsome enzyme converts omega-hydroxyleukotriene e4 to 20-carboxyleukotriene e4
omega-phonetoxin-IIA, Phoneutria nigriventer: a calcium channel blocker; amino acid
omega76: synthetic antimicrobial peptide with efficacy against carbapenem and tigecycline-resistant acinetobacter baumannii
omentin protein, rat: an adipocytokine that inhibits platelet-derived growth factor-bb-induced vascular smooth muscle cell migration through antioxidative mechanism
omeprazole, sodium bicarbonate drug combination: santarus inc. has developed an immediate-release formulation of omeprazole in combination with an antacid (sodium bicarbonate) as a powder for suspension, known as acitrel [san 05], and also as rapinex powder for oral suspension; potential treatment for gi diseases
omidenepag isopropyl: selective prostaglandin ep2 receptor agonist
omiganan pentahydrochloride: a cationic peptide with antibacterial activity
omnadin: minor descriptor (75-82); online & index medicus search lipoproteins (66-82)
omomyc protein: a 90-mer version of myc protein with a mutated dimerizaton domain; binds c-myc and n-myc proteins to inhibit their transcription factor activity
omp-40 protein, Acidithiobacillus ferrooxidans: the major outer membrane protein from the acidophilic bacterium thiobacillus ferrooxidans; amino acid
omp1 protein, Chlamydia trachomatis: amino acid sequence given in first source
ompB1 protein, Moraxella catarrhalis: a protective epitope of outer membrane protein b1 defined by monoclonal antibody 11c6; amino acid ; genbank af105251
ompL1 protein, Leptospira: a 31 kda transmembrane outer membrane protein; amino acid sequence given in first source; genbank l13284
ompN protein, E coli: a quiescent porin gene product from escherichia coli; genbank af035618
ompR protein, Salmonella typhimurium: genbank ae006468.2
ompT protein, E coli: ompt is an outer membrane protease with specificity for paired basic residues; responsible for hydrolysis of the antimicrobial peptide protamine; a virulence determinant in urinary tract infections
ompT protein, bacteria: a toxr-repressed gene product from vibrio cholerae; do not confuse with ompt protein, e coli which is a protease
ompW protein, E coli: 22 kda immunogenic outer membrane protein form vibrio cholerae; amino acid sequence given in first source
omptin outer membrane protease: from e coli outer membrane; specifically cleaves the peptide bond between consecutive basic residues
omtA protein, Aspergillus: catalyzes the conversion of sterigmatocystin (st) to o-methylsterigmatocystin (omst) and dihydro-st to dihydro-omst which takes place in the latter stages of aflatoxin biosynthesis
omtB protein, Aspergillus: highly homologous to stcp from a. nidulans; amino acid ; genbank af154050
omtriptolide: a water-soluble, semisynthetic derivative of pg490 (triptolide) purified from the chinese herb tripterygium wilfordii
onapristone: induces vaginal bleeding and luteal regression in monkeys; ; progesterone antagonist
onchidal: major lipid-soluble component of the defensive secretion of the mollusk onchidella binneyi; responsible for the chemical protection of onchidella
oncocalyxone A: a 1,4-anthracenedione isolated from auxemma oncocalyx (boraginaceae) that has been shown to be cytotoxic to tumor cells in vitro
oncocalyxone C: a 1,4-anthracenedione isolated from auxemma oncocalyx (boraginaceae) that has been shown to be cytotoxic to tumor cells in vitro
oncodevelopmental protein, 28-kDa: exhibits high sequence homology with calcium-binding protein mrp8; partial amino acid sequence given in first source
oncofetal antigens: see also record for pancreas-specific antigen & pancreas cancer-associated antigen, which is different from oncofetal antigens
oncofetal fibronectin: useful for preoperative diagnosis of thyroid papillary and anaplastic carcinomas; has been sequenced
oncogene protein E1, Human papillomavirus type 18: a 73-kda protein; has been sequenced
oncogene protein E2, Human papillomavirus type 1: conserved cysteine residue in its dna-binding domain confers redox regulation of the dna-binding activity in vitro; partial amino acid sequence given in first source
oncogene protein E2, Human papillomavirus type 18: amino acid sequence has been determined
oncogene protein E4, Human papillomavirus type 16: partial amino acid sequence given in first source
oncogene protein E5, Bovine papillomavirus type 1: 44-amino acid protein; a homo-dimeric, transmembrane protein that transforms cells by activating the platelet-derived growth factor ss receptor in a ligand-independent fashion and induces cellular dna synthesis
oncogene protein E5, Human papillomavirus type 16: amino acid sequence given in first source
oncogene protein E5-E8, bovine papillomavirus type 4: has been sequenced
oncogene protein E7, Bovine papillomavirus type 1: has been sequenced
oncogene protein E7, Human papillomavirus type 16: amino acid sequence given in first source
oncogene protein E7, Human papillomavirus type 8: non-phosphorylated protein ; mw 17kda; can be generated through translation of an e7-specific mrna or through internal initiation of translation of the atg of e7
oncogene protein Qin, Avian retrovirus: oncogenic transformation by the fox protein qin requires dna binding; has been sequenced; do not confuse with cellular qin
oncogene protein trk: human cellular sequence given in first source; involved in dna damage; do not confuse with proto-oncogene protein trk
oncogene viral capsid protein L2, human papillomavirus type 33: antisera obtained by using l2 may be useful as immunological probe; amino acid sequence has been determined
oncohist: consists of recombinant histone h1.3 and bis-met-histone h1.3; for the treatment of leukemia
oncoimmunin-M: a tumor cell-derived 36 kda protein with sequence identity to lactate dehydrogenase type m; inhibits the proliferation of human promyelocytic cell line
oncolipids: tumor marker; lipid moieties of lipoprotein particles found in plasma of patients with cancer; different from lipids of healthy individuals; difference can be detected by mrs
oncolipin: a multilamellar liposomal (dimyristoyl phosphatidylcholine) formulation of interleukin 2 (il-2) and human serum albumin (hsa)
oncomodulin: cytoplasmic calcium-binding protein found only in tumor cells; mw 11,500; not a fragment of calmodulin; stimulates liver cell dna synthesis
oncoprotein CLTCL-ALK: encoded by the anaplastic lymphoma kinase, alk gene fused to the second clathrin heavy chain gene (also referred to as clathrin heavy polypeptide-like gene, cltcl); associated with alk-positive lymphomas; amino acid
onecut protein, Drosophila: perhaps involved in neural differentiation; genbank af169227
onecut3a protein, zebrafish: involved in biliary development; refseq nm_200573
onion oil: dipropenyl sulfide & dipropenyl disulfide are constituents
onionin A: from bulbs of onion (allium cepa); suppress tumor-cell proliferation
onitin: from onychium siliculosum; ; rn from chem abst index guide 1985; rn not in chemline 9/85
onitinoside: from onychium siliculosum; ; rn from chem abst index guide 1985; rn not in chemline 9/85
onitisin: from onychium siliculosum; ; rn refers to (-)-isomer
onjisaponin F: from the root of polygala tenuifolia willdenow (polygalaceae)
onnamide F: from southern australian marine sponge, trachycladus laevispirulifer
ononitol monohydrate: antioxidant from cassia tora l. leaves
onopordopicrin: ; isolated from centaurea sonchifolia; rn given is for (3ar-(3ar*,4s*,6e,10z,11ar*))-isomer
onoseriolide: an antileishmanial agent isolated from hedyosmum angustifolium
onosmanone A: quinonoid xanthene isolated from whole plants of onosma paniculatum
onosmanone B: quinonoid xanthene isolated from whole plants of onosma paniculatum
ontamalimab: fully human igg2k mab for treatment of inflammatory bowel diseases
ontazolast: inhibits arachidonate release that blocks leukotriene b4 and platelet-activating factor biosynthesis in human neutrophils
ontuxizumab: an antineoplastic agent that targets endosialin; in phase i clinical trials (2015)
onvansertib: atp-competitive polo-like kinase 1 (plk1) inhibitor
onychine: from cleistopholis patens; ; rn from chem abst. index guide 1986
onychofissan tincture: rn is for parent cpd without dmso; combination drug containing hydroxyquinoline salicylate, undecylenic acid diethanolamide, dichlorophene & dimethyl sulfoxide
onzin protein, mouse: c-myc-repressed target that promotes survival and transformation by modulating the akt-mdm2-p53 pathway; murine and human onzin are 82% identical; genbank af26345
ooc-3 protein, C elegans: a transmembrane protein required for establishment of cortical domains and spindle orientation in the p1 blastomere of c. elegans embryos; amino acid
oocyst wall protein, Cryptosporidium: 1622 amino acids; localized in inner layer of oocyst; amino acid sequence given in first source; genbank z22537
oogenesin protein, mouse: has some roles in zygotic transcription of early preimplantation embryos as well as folliculogenesis and oogenesis in the mouse
ookinete antigen P25, Plasmodium: candidate in the development of a transmission blocking malaria vaccine; amino acid sequence given in first source
ookinete surface antigen Pbs21, Plasmodium: candidate in the development of a transmission blocking malaria vaccine; similar to p25 & pgs28; 213 amino acids; mw 21-23.5 kda; amino acid sequence given in first source
oosporein: from chaetomium trilaterale; found in moldy peanuts
opacity factor: cell bound lipoproteinase causing appearance of opacity in mammalian sera from generation of insoluble lipid moieties; group a strep produce it
opacity factor receptor, Neisseria gonorrhoeae: belongs to the syndecan family of proteoglycans; receptor for the invasion-promoting gonococcal opacity protein adhesin
opacity proteins: opa proteins are variable outer membrane proteins of neisseria gonorrhoeae and neisseria meningitidis that mediate tight interaction of these pathogens with human cells; do not confuse with op zinc finger protein
opaliferin: from cultures of entomopathogenic fungus cordyceps sp. nbrc 106954
opantimycin A: isolated from a microbial metabolite fraction library generated from streptomyces sp. rk88-1355; has cytotoxic and antimalarial properties
opaque-2 protein, Zea mays: found in maize; amino acid sequence has been determined
opc protein, bacteria: amino acid sequence given in first source; a class 5 protein from neisseria meningitidis & burkholderia, cloned & expressed in escherichia coli
opdA protein, Sphingomonas: involved in biodegradation of the endocrine disrupter octylphenol; genbank eu002557, eu004850
operculinic acid: from the leaves of the native north american prairie plant ipomoea leptophylla (big root morning glory), shows in vitro activity against m. tuberculosis
opgH protein, E coli: mdo - membrane-derived oligosaccharides; a 97 kda membrane protein involved in the biosynthesis of mdo in escherichia coli; its required for normal glycosyltransferase activity, it could be a glucosyl transferase or simply a subunit of the enzyme; amino acid sequence given in first source; homologous to hrpm protein, p. syringae; genbank x64197
ophD protein, Burkholderia cepacia: ophd isolated from burkholderia cepacia; has been sequenced; genbank af152094 (ophd)
ophiobolin A: sesterterpene; phytotoxin produced by plant pathogen helminthosporium maydis; natural product inhibitor of calmodulin; rn refers to (18r)-isomer
ophiobolin F synthase, Aspergillus clavatus: a sesterterpene synthase
ophiobolins: tricyclic sesterterpenes, include ophiobolins a,b,c,d,f; rn in chemline for ophiobolin a: 4611-05-6; rn for ophiobolin b: 5601-74-1; rn for ophiobolin c: 19022-51-6
ophioceric acid: africane sesquiterpenoid from cultures of the aquatic fungus ophioceras venezuelense
ophiodilactone A: cytotoxic compound from the ophiuroid ophiocoma scolopendrina
ophiodilactone B: cytotoxic compound from the ophiuroid ophiocoma scolopendrina
ophioglonin 4'-O-beta-D-glucopyranoside: from the fern ophioglossum pedunculosum
ophiohayatone A: from ophiorrhiza hayatana ohwi (rubiaceae)
ophiohayatone B: from ophiorrhiza hayatana ohwi (rubiaceae)
ophiohayatone C: from ophiorrhiza hayatana ohwi (rubiaceae)
ophioluxin, Ophiophagus hannah: from the venom of ophiophagus hannah (king cobra); 85 kda
ophioparmin: pyranonaphthoquinone from the lichen ophioparma ventosa
ophiopogonin B: rn given refers to (1beta,3beta,25r)-isomer
ophiopogonin D: rn given refers to (1beta,3beta,25r)-isomer
ophiopogonoside A: new cis-eudesmane sesquiterpene glycoside from ophiopogon japonicus
ophiopogonoside B: from liriope muscari; showed moderate inhibitory activity to glycogen phosphorylase a
ophiosetin: from the mycopathogenic fungus elaphocordyceps ophioglossoides
ophirapstanol trisulfate: rn refers to 3na salt; isolated from the deep water sponge topsentia ophiraphidites
ophirasterol: a c31 sterol from the marine sponge topsentia ophiraphidites
ophthalmic acid: glutathione analog in which cysteine moiety is replaced by l-aminobutyrate
opine dehydrogenase, NAD+: acts on opine-type secondary amine dicarboxylic acids, producing an amino acid & an alpha keto acid by oxidative deamination with nad+
opiomelanin: opioid peptides converted by tyrosinase into melanin-like compounds in which the peptide moiety is retained
oplodiol: rn given for (1s-(1alpha,4alpha,4aalpha,8abeta))-isomer
oplopanone 10-O-(5-O-syringoyl)apiofuranosyl-(1-2)glucopyranoside: from the leaves of aglaia perviridis
oplopanpheside A: antineoplastic from the root barks of oplopanax horridus
oplopanpheside B: antineoplastic from the root barks of oplopanax horridus
oplopanpheside C: antineoplastic from the root barks of oplopanax horridus
oplunofusp: antiviral; a sialidase fusion protein (consisting of sialidase catalytic domain derived from actinomyces viscosus fused with respiratory epithelium-anchoring domain) that protects mice from lethal avian influenza h5n1 virus infection
opm protein, Drosophila: a p24 protein that may be involved in intracellular trafficking; has been sequenced; refseq nm_132766
oppositine A: sesquiterpene pyridine alkaloid from a sri lankan pleurostylia opposita
oppositine B: sesquiterpene pyridine alkaloid from a sri lankan pleurostylia opposita
oppositinine A: vasorelaxant alkaloid from neisosperma oppositifolia
oppositinine B: vasorelaxant alkaloid from neisosperma oppositifolia
oprA protein, Pseudomonas aeruginosa: genbank abr81584.1
oprP protein, Pseudomonas aeruginosa: phosphate-starvation-inducible porin is a phosphate-specific outer membrane channel; from pseudomonas aeruginosa
oprQ protein, Pseudomonas aeruginosa: mw~44kda; amino acid
oprd1a protein, zebrafish: isolated from the teleost zebrafish (danio rerio); a 373 amino acid protein with seven potential transmembrane domains that shows a high degree of homology to mammalian delta opioid receptor; refseq nm_131258
oprin: amino acid sequence given in first source; inhibits snake venom metalloproteinases; has 36% homology with human alpha(1)b glycoprotein
oprm1 protein, zebrafish: an opioid receptor-like gene from the teleost zebrafish (danio rerio); amino acid ; genbank af132813
oracin reductase: stereospecific and gender-specific rat enzyme which reduces the 11-oxo group of oracin; requires nadph
orange carotenoid protein, Synechocystis: water soluble protein from the cyanobacterium synechocystis pcc6803; amino acid
orantine: spermine alkalpid; from schweinfurthia papilionacea
orb protein, Drosophila: required for egg chamber formation in drosophila; has been sequenced; refseq nm_079736
orbicularisine: isolated from gills of the tropical bivalve codakia orbicularis
orchestin protein, Orchestia cavimana: from the crustacean, orchestia cavimana; encoding an acidic protein; this protein is a component of the organic matrix of calcium storage structures (calcareous concretions); amino acid ; genbank af124526
orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; rn given refers to parent cpd
orcokinin: amino acid sequence given in first source; a myotropic peptide isolated from the crayfish orconectes limosus
orcokinin, Ala(13)-: from the shore crab, carcinus maenas; amino acid sequence given in first source
orcokinin, Ser(9)-: from the shore crab, carcinus maenas; amino acid sequence given in first source
orcokinin, Val(13)-: isolated from the shore crab, carcinus maenas; amino acid sequence given in first source
oregonin: a diarylheptanoid from the bark of alnus hirsuta var. sibirica; inhibits cyclooxygenase-2 expression
oren gedoku to: traditional chinese mix of scutellaria root, coptis rhizome, gardenia fruit, phellodendron bark in the ratio 3:2:2:1.5; one of which is ougon; huanglian-jie-du-tang is chinese term
oreoselone: coumarins from the aerial part of halocnemum strobilaceum
orexin-SAP: neurotoxin; orexin-saporin conjugate
orf0 protein, Pseudomonas pseudoalcaligenes: encoded by the biphenyl catabolic bph operon in pseudomonas pseudoalcaligenes; amino acid ; genbank d85852; 20% identical to gntr protein
orf1 protein, Aedes aegypti: differentially expressed in aedes aegypti during melanotic encapsulation of filarial worms; genbank u11235
orf184 protein, Synechocystis: isolated from synechocystis; amino acid ; genbank z27404
orf224 protein, Brassica napus: a chimeric mitochondrial protein associated with cytoplasmic male-sterility in brassica; amino acid sequence given in first source
orf29 protein, Listeria monocytogenes: orf29 is a member of the dnak operon; isolated from listeria monocytogenes; amino acid
orf35 protein, Bacillus subtilis: member of the dnak operon; isolated from bacillus subtilis and listeria monocytogenes; amino acid ; genbank d83717 (bacillus subtilis)
orf97 protein, Enterobacteria phage 186: its presence in the cell totally blocks infection of that cell by coliphage 186; amino acid sequence given in first source
orfF protein, archaea: member of atp-binding cassette (abc)-transporter family
orforglipron: an oral, non-peptide glucagon-like peptide-1 receptor agonist
org protein, zebrafish: zorg - zebrafish oogenesis related gene; amino acid ; refseq nm_001100070
org-1 protein, Drosophila: 712 amino acid residues; from drosophila melanogaster; homolog of human tbx1; amino acid ; genbank y16899
organ-specific neoantigen: an antigen specific to all cancers arising from the same organ and histogenesis; the basis for the lai assay, in which leukocytes of cancer patients lose ability to adhere to glass upon exposure to this antigen in vitro
organellar oligopeptidase, Arabidopsis: refseq nm_125960
organic anion transporter like protein 1, mouse: expressed in the kidney; genbank ak052752
organic anion transporting polypeptide 4C1, mouse: refseq nm_172658.1; np_766246.1
organic anion transporting polypeptide 4C1, rat: genbank af454761
organic hydroperoxide resistance protein, Xanthomonas campestris: ohr - organic hydroperoxide resistance; isolated from x; amino acid
orgotein: mainly alpha-helical partly divalent metal (mg,cu,zn) chelated water soluble protein (mw-34000) from bovine liver; for treatment of cystitis; has superoxide dismutase activity
oriLyt protein, Human cytomegalovirus: dna replicator; human cytomegalovirus lytic-phase; has been sequenced
oriciacridone A: alkaloid from the stem bark of oriciopsis glaberrima (rutaceae)
oriciacridone B: alkaloid from the stem bark of oriciopsis glaberrima (rutaceae)
oridamycin A: anti-saprolegnia parasitica compound from streptomyces sp. ks84
oridamycin B: anti-saprolegnia parasitica compound from streptomyces sp. ks84
oridonin: antineoplastic agents, phytogenic from isodon; structure; rn given refers to (alpha,6beta,7alpha,14r)-isomer; rn for parent cpd not available 10;90
orientin: ; rn given refers to the (d-glucopyranosyl)-isomer
orientin-2''-O-galactopyranoside: has both anti-inflammatory and neuroprotective activities
origanum oil: origanum vulgare oil also known as wild marjoram oil; rn in chemline for origanum marjorana oil: 8015-01-8
origin-binding protein, Human herpesvirus 6B: has been sequenced; genbank l14772
origin-binding proteins, viral: plays an essential role in productive infection by promoting the initiation of viral dna synthesis
orixalone A: quinolone alkaloid with nitric oxide production inhibitory activity from orixa japonica
ormetoprim: proposed chemotherapeutic agent; minor descriptor (75-84); on-line & index medicus search pyrimidines (75-84)
ormetoprim, sulfadimethoxine drug combination: combination drug containing ormetoprim & sulfadimethoxine
ornatin: from leech placobdella ornata; potent glycoprotein iib-iiia antagonist & platelet aggregation inhibitor; amino acid sequence has been determined
ornithine 5,4-aminomutase: ec 5.4.3.1 has been deleted; reaction was due to a mixture of ec 5.1.1.12 & ec 5.4.3.5
ornithine containing aminolipid: from thiobacillus ferrooxidans grown in ferrous sulfate medium; contains mainly c18:1 & c22:1 fatty acids
ornithine decarboxylase antizyme: non-competitive inhibitor of ornithine decarboxylase induced by millimolar concentrations of putrescine; refseq nm_008753 (mouse); nm_052998 (odc-p, human); nm_139081 (rat); nm_004152 (oaz1, human)
ornithine decarboxylase antizyme inhibitor: inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme
ornithine hydroxylase, Pseudomonas aeruginosa: a flavin adenine dinucleotide-dependent monooxygenase that catalyzes the conversion of ornithine to n(delta)-hydroxyornithine
ornithine racemase: highly specific for ornithine; a 92 kda pyridoxal 5'-phosphate-dependent enzyme from clostridium sticklandii
orobanchol: a germination stimulant for root parasitic weeds; isolated from tobacco
orobol: from aspergillus niger or streptomyces neyagawaensis; potent inhibitor of phosphatidylinositol kinase
orochrine: from the bhutanese medicinal plant aconitum orochryseum
oroxylin A-7-O-glucuronide: an inhibitor of prolyl oligopeptidase; isolated from scutellaria racemosa and scutellariae baicalensis
orsellinic acid: from the sonoran desert endophytic fungus chaetomium globosum
orsellinylmontagnetol A: has antineoplastic activity; isolated from roccella montagnei
ort protein, Drosophila: drosophila histamine-gated chloride channel; has been sequenced
ortho-2,2',2'',2'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzenesulfonic acid: a p2x receptor antagonist
ortho-chlorophenol reductive dehalogenase: catalyzes reductive removal of an ortho-position halide in the presence of methyl viologen; a member of the halorespiration pathway of desulfitobacterium dehalogenans; amino acid ; genbank af115542
ortho-halobenzoate 1,2-dioxygenase: a three-component broad substrate-specific enzyme that requires oxygen, nadh, fe(ii) & flavin adenine dinucleotide; degrades 2,4-, 2,5-dichloro-, 2-chloro (& a variety of other substituted halobenzoates) to 4-chlorocatechol & catechol
orthoclase: rn given refers to cpd with mf of al-h-o8-si3-k
orthoesterol B: a marine steroidal orthoester from sponge, petrosia weinbergi
orthoformimycin: a selective inhibitor of bacterial translation elongation from streptomyces
orthosiphol A: hypoglycemic from the aerial parts of orthosiphon aristatus
orthosiphonone C: from orthosiphon stamineus of taiwan; has nitric oxide inhibitory activity
orthosiphonone D: from orthosiphon stamineus of taiwan; has nitric oxide inhibitory activity
orthosphenic acid: ; isolated from tripterygium wilfordii; rn given from cas index guide 1989; rn given for (2alpha,3beta,20alpha)-isomer; rn for cpd without isomeric designation not avail 6/90
oryeongsan: composed of five dried herbs: alismatis rhizoma (alisma orientale juzepzuk), poria sclerotium (poria cocos wolf), atractylodis rhizoma alba (atractylodes macrocephala koidzumi), polyporus (polyporus umbellatus fries), and cinnamomi cortex (cinnamomum cassia): goreisan: alisma tuber, atractylodes lancea rhizome, polyporus sclerotium, poria sclerotium, and cinnamon bark
orysata protein, Oryza sativa: a mannose-binding lectin isolated from salt-stressed rice; amino acid ; genbank af001395
oryzamide A: from the sponge-derived fungus nigrospora oryzae pf18
oryzamutaic acid A: yellow-colored endosperm is associated with its accumulation in rice
oryzasin: aspartic protease from rice; amino acid sequence given in first source; genbank d32144 (cdna) and d32165 (genomic dna)
oryzatensin: released from rice soluble protein upon digestion with trypsin; amino acid
oryzin: catalyzes hydrolysis of proteins; does not split peptide amides; formerly included in the group of microbial serine proteinases ec 3.4.21.14; formerly ec 3.4.21.15
os-2 protein, Neurospora crassa: encodes a putative mitogen-activated protein (map) kinase homologous to hog1 and can complement the osmosensitive phenotype of a saccharomyces cerevisiae hog1 mutant; genbank af297031
osa protein, Drosophila: the trithorax group gene osa encodes an arid-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription
osajaxanthone: has been isolated from the stem bark of calophyllum enervosum
oscillamide B: inhibited serine/threonine protein phosphatases pp1 and pp2a; from the cyanobacteria planktothrix (oscillatoria) agardhii and p. rubescens; structure in first soura
oscillamide C: inhibited serine/threonine protein phosphatases pp1 and pp2a; from the cyanobacteria planktothrix (oscillatoria) agardhii and p. rubescens; structure in first soura
oscillamide Y: inhibited serine/threonine protein phosphatases pp1 and pp2a; from the cyanobacteria planktothrix (oscillatoria) agardhii and p. rubescens
oscillapeptin J: a grazer toxin of the freshwater cyanobacterium planktothrix rubescens
oscillatoxin I: oscillatoxin i (1) showed 100% inhibition activities in both cytotoxicity and diatom growth inhibition
oscillin: 33-kda oscillogen isolated from hamster sperm; oscillogens are calcium oscillation-inducing proteins; amino acid ; genbank m19284
oscillin protein, Phormidium uncinatum: an extracellular glycoprotein essential for the gliding motility of cyanobacteria; mw about 66 kda; genbank af002131
osimol: contains sodium propionate, citric acid, cobalt so(4) copper sulfate, magnesium sulfate
osk protein, Drosophila: a drosophila maternal effect protein oskar, necessary for germline & abdomen formation; has been sequenced; refseq nm_169248
osladin: steroidal saponin; rn refers to (3beta,5alpha,22s,25r,26r)-isomer
osm-12 protein, C elegans: bbs-7 and bbs-8 are required to stabilize complexes of ift particles containing both of the ift motors; refseq nm_067184.1
osmC protein, E coli: 14-kda osmotically inducible gene product from e. coli k-12; amino acid
osmY protein, E coli: amino acid sequence given in first source; isolated from e coli; a periplasmic protein
osmium ferricyanide: improves microfilament preservation & membrane visualization in a variety of animal cell types
osmium tetroxide bispyridine: complexes dna; do not confuse with os-bipy
osmium-thiocarbohydrazide: used in high resolution scanning electron microscopic (sem) observations of human zona pellucida (zp)
osmolarity response regulator proteins: from a mutant strain that forms biofilms on inert surfaces & increases curli expression; has been sequenced
osmosensing scaffold for MEKK3 protein, mouse: a scaffold protein that binds to actin, the gtpase rac, and the upstream kinases mekk3 and mkk3 in the p38 mapk phospho-relay module; don't confuse with oncostatin m (gene symbol osm), genbank ay442689
osmotic shock released antigen: membrane protein from sheep erythrocytes which elicits an immune response in cba mice
osmotin protein, Nicotiana tabacum: from nicotiana tabacum cv. white burley; amino acid sequence given in first source
osocimab: a long-acting, fully human monoclonal antibody that inhibits factor xia
ostalactone A: lipase inhibitor from the cultured basidiomycete stereum ostrea
ostalactone B: lipase inhibitor from the cultured basidiomycete stereum ostrea
ostalactone C: lipase inhibitor from the cultured basidiomycete stereum ostrea
osteoadherin: cell-binding keratan sulfate proteoglycan isolated from bone; genbank u67279
osteoblast cadherin: member of cadherin family from osteoblasts, involved in bone formation; genbank af177677 (rat); refseq nm_009866 (mouse); nm_033664 (human)
osteoblast specific factor 3: plays an intrinsic role in the proliferation and/or differentiation of bone cells; homologous to mer5 protein; mw 22,176 da; amino acid sequence given in first source; genbank d21252
osteochondrin S: a ribonucleinate derived from bovine connective tissue and yeast extracts
osteoclast activating factor: found in supernatants of cultured human leukocytes; assayed by ability to stimulate bone resorption in organ culture in mechanism of localized bone loss
osteoclast functional antigen, Cercopithecus aethiops: implicated in regulation of bone resorption; heterodimeric molecule 140 kda (alpha chain) & 85 kda (beta chain) under nonreducing conditions; shows considerable homology with vitronectin receptor; amino-terminal amino acid sequence given in first source
osteoclast stimulating factor: an intracellular protein produced by osteoclast is an sh3-domain containing protein; may be involved in cbl and src-mediated pathways; has been sequenced
osteoclastpoietic factor: stimulates the formation and differentiation of osteoclasts in vitro; expressed in tumor cells, stromal cells & activated leukocytes; mw 17 kda; amino acid sequence has been determined
osteogenic growth peptide: circulating stimulator of osteoblastic activity; identical to the c-terminus of histone h4; see also osteogenin; amino acid sequence of 14 amino acids given in first source
osteogenic protein 1 putty, recombinant human: recombinant human protein powder and bovine collagen mixed with sterile saline and a thickening agent to form a putty-like material (http://www.fda.gov/cdrh/mda/docs/h020008.html accessed june 29 2006)
osteoking: used in preventing post-op deep venous thrombosis; composition in first source
osteopoietin: a heat-stable glycoprotein produced during bone marrow regeneration; involved in humoral induction in osteogenesis
osteosarcoma-associated antigen: expressed in human & dog osteosarcoma cells
osthol: from cnidium monnieri and angelica pubescens (both apiaceae)
ostreol A: isolated from cultures of the epiphytic dinoflagellate ostreopsis cf.
ostreol B: a polyhydroxy tetrahydropyran compound isolated from toxic dinoflagellate ostreopsis cf. ovata
ostreolysin: purified from the fruiting bodies of the edible mushrooms pleurotus ostreatus; amino acid
osyrisine: from osyris alba l. (santalaceae), exhibited a significant antiparasitic activity against entamoeba histolytica and giardia intestinalis
otaplimastat: neuroprotectant from purified coelomic fluid of live earth worm (eisenia andrei)
otcD1 protein, Streptomyces rimosus: bifunctional cyclase/aromatase from streptomyces rimosus involved in ring closure of the polyketide backbone of oxytetracycline; amino acid
oterna: combination drug for treating otitis externa in dogs & cats containing betamethasone, neomycin, & monosulfiram
otobanone: component of nutmeg (myristica simarum a.dc.)
otocinin-22 protein, Xenopus: amino acid sequence given in first source; the major protein of the aragonitic otoconia; 37% homology with phospholipase a2
otogl2 protein, Xenopus: an epidermis-specific gene; amino acid ; genbank l10987
otokeratin protein, chicken: closely related to type ii cytokeratin; mw 54 kda; genbank af072698
otopetrin 1 protein, mouse: a non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice is caused by mutations in otopetrin 1; amino acid
otostegindiol: antimalarial from the leaves of otostegia integrifolia benth
otx2a protein, zebrafish: required for formation of both the zona limitans intrathalamica and irx1b-positive thalamus; ref seq nm_131215
oubatchensine: seco-dibenzopyrrocoline alkaloid from cryptocarya oubatchensis
ougi-keishi-gomotsu-to: a combination of five plants: astragali radix, cinnamomi cortex, paeoniae radix, zigiberis rhizoma and zizphi fructus
outO protein, Erwinia carotovora: an nmephe prepilin peptidase involved in the general secretory pathway for secreting pectinase and cellulase; isolated from erwinia carotovora; amino acid
outer envelope membrane protein 34-kDa: a constituent of the chloroplast import complex from pea; amino acid sequence given in first source; genbank z28341
outer membrane lipoprotein I, Bacteria: vaccine candidate; antigenically cross-reacts with all serotype strains of the international antigenic typing scheme; amino acid sequence given in first source
outer membrane phospholipase A: an integral membrane phospholipase that is active as a homodimer and requires calcium as a cofactor
outer membrane protein CD, Moraxella catarrhalis: an adhesin for human lung cells; genbank ay493741
outer membrane protein G1a, Moraxella catarrhalis: lipoprotein & potential vaccine antigen for m. catarrhalis
outer membrane protein G1b, Moraxella catarrhalis: potential vaccine antigen for m. catarrhalis
outer membrane protein P1, Haemophilus influenzae type b: amino acid sequence has been determined
outer membrane protein P2, Haemophilus influenzae type b: amino acid sequence has been determined
outer membrane protein P5, Haemophilus: similar to ompa of e. coli; from h. influenzae; mw 35 kda; amino acid sequence given in first source
outer membrane protein p18, Campylobacter: isolated from campylobacter jejuni; amino acid ; genbank x83374
outer membrane protein, Chlamydia psittaci 6BC: amino acid sequence given in first source
outer membrane protein, Rahnella: isolated from rahnella aquatilis; amino acid ; genbank aj002879
outer surface protein D, Borrelia burgdorferi: 28 kda protein; amino acid sequence given in first source; low-passage-associated proteins of borrelia burgdorferi b31
outovirin A: from penicillium raciborskii, an endophytic fungus of rhododendron tomentosum harmaja
outovirin B: from penicillium raciborskii, an endophytic fungus of rhododendron tomentosum harmaja
outovirin C: from penicillium raciborskii, an endophytic fungus of rhododendron tomentosum harmaja
ouvrardiantine: diterpenoid alkaloid from roots of aconitum ouvrardianum
ovCNP-39 peptide: a 39-residue c-type natriuretic peptide (cnp) from venom of ornithorhynchus anatinus; relaxes rat uterus, promotes edema and mast cell histamine release; amino acid
oval cell antigen, human: a polymorphic cell surface antigen; a marker for precursor cells that differentiates both to haemapoietic and endothelial cells
oval cell marker OV-6: a putative progenitor cell marker in fetal & diseased pediatric liver
ovalicin: sesquiterpene isolated from culture filtrate of fungus pseudorotium ovalis; shows antitumor activity
ovalifoliolatin A: macrocyclic diaryl ether heptanoid from boswellia ovalifoliolata
ovalifoliolatin B: macrocyclic diaryl ether heptanoid from boswellia ovalifoliolata
ovaprim: consists of sgnrha and domperidone; used to induce spawning in catfish
ovarian cancer immuno-reactive antigen domain containing 1, human: over-expressed in metastatic ovarian cancer. effect of ociad1 on cell adhesion may be related to its function in ovarian cancer. possibility of ociad1's role in tumor metastasis
ovarian peritrophin, Fenneropenaeus chinensis: antimicrobial; an engineered protein
ovarian protein, trout: an osteopontin-like protein expressed in the trout ovary during ovulation; mw 36 kda; genbankk af223388
ovary maturating parsin protein, Locusta migratoria: from the nervous corpora cardiaca of the african locust locusta migratoria migratorioides; amino acid sequence given in first source; rn given is for 26-l-ser
ovate family protein 1, Arabidopsis: suppresses cell elongation; refseq nm_120262
ovate family protein 4, Arabidopsis: suppresses cell elongation; refseq nm_100566
ovatolide: found in the leaves of bridelia ovata, which are used in traditional thai medicine as a laxative, febrifuge, and astringent
oviduct-specific glycoprotein, Mesocricetus auratus: amino acid ; genbank d32218
oviductin: n-terminal amino acid sequence given in first source; processes xenopus laevis envelope glycoprotein gp43 by cleaving an arginyl-x bond; inhibited by diisopropyl fluorophosphate, edta, egta, soybean trypsin inhibitor, aprotinin and guanidine hcl; mw 66,000
oviedomycin: an unusual angucyclinone encoded by genes of the oleandomycin-producer streptomyces antibioticus
ovo protein, Drosophila: required for survival & germ line sex determination; genbank u11383
ovocalyxin 32: an eggshell matrix protein; genbank aj307060
ovochymase: a chymotrypsin-like protease; released during xenopus egg activation; partial amino acid sequence given in first source
ovocleidin 17: a soluble matrix protein of the chicken eggshell; mw 17 kda; has been sequenced
ovocleidin-116: an eggshell matrix protoglycan protein; amino acid
ovohemerythrin: 14-kda protein; major component of mature oocytes of the leach theromyzon tessulatum; amino acid composition given in first source; n-terminal amino acid sequence also given in first source
ovomacroglobulin: macroglobulin from freshly laid egg white with protease inhib activity toward trypsin, papain, & thermolysin; contains 4 subunits of equal mw(175,000); subunit & amino acid comp related to human serum alpha-2 macroglobulin
ovomucoid inhibitors: belong to pancreatic secretory trypsin inhibitor (kazal) family; tomi is a 56-residue elastase inhibitor
ovothiol C: confers nad(p)h-o2 oxidoreductase activity on ovoperoxidase; from sea urchin eggs
owariensisone: from the whole plant of brillantaisia owariensis p. beauv
oxachamigrene: sesquiterpene with a novel oxacyclic structural type of chamigrene skeleton from the red alga laurencia obtusa
oxachelin: an iron chelating agent with antifungal activity; isolated from streptomyces
oxacillinase: a penicillin-binding protein that is related to class c beta-lactamases; oxa_162 is a point mutation of oxa-48; amino acid
oxadiarrhot: active component is 1,3,4-oxadiazine derivative, c-6; see record for compound c-6
oxadilene: combination of papaverine & butalamine used in treating ulcers of arterial & venous origin
oxadin: a 2,3-dihydro-6h-1,3,4-oxadiazine product; inhibits a variety of rna & dna, as well as retroviruses, in vivo & in vitro; see also record for oxadiarrhot
oxaflozane: rn given refers to parent cpd; synonym 1766 cerm refers to hcl
oxalatobis(2-phenylazopyridine)ruthenium(II): has antineoplastic activity
oxaldie 1: 14-amino acid residue peptide consisting mainly of leucine & lysine; catalyzes the decarboxylation of oxaloacetate; forms an alpha-helical tetramer; the terminal amino groupof the peptide chain is left free to serve as the reactive amine; aa sequence given in first source
oxaldie 2: 14-amino residue synthetic peptide which catalyzes the decarboxylation of oxaloacetate; the amino terminal amine of lysine is blocked; the reactive amine therefore comes from a lysine side chain; aa sequence given in first source
oxaline: a fungal alkaloid from the culture broth of penicillium oxalicum
oxaloacetate tautomerase: from fuma gene of e coli; catalyzes the isomerization of enol to keto oxalacetic acid
oxalyl CoA decarboxylase: catalyzes the thiamine ppi-dependent decarboxylation of oxalyl-coa to formate & carbon dioxide
oxalyl-CoA synthetase, S cerevisiae: acyl-activating enzyme 3 (scaae3)
oxalyldiaminopropionic acid: neurotoxin found in peas of lathyrus; prolonged ingestion of such seed (a few months) causes lathyrism; minor descriptor (75-84); on-line & index medicus search amino acids, diamino (75-84); rn given refers to cpd without isomeric designation
oxamarine: used in treatment of varicose veins; rn given refers to parent cpd
oxamate carbamoyltransferase: phosphorylizes oxalurate to oxamate
oxanine: an altered form of guanine produced by action of nitric oxide or nitrous acid