NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
proline, 2-oxoglutarate 3-dioxygenase: prolyl 3-hydroxylase is separate enzyme from prolyl 4-hydroxylase; catalyzes post translational modification of collagen
proline-rich Akt substrate, 40 kDa protein, mouse: an akt1 substrate; has been sequenced
proline-rich cell wall proteins, soybean: amino acid sequences for sbprp2 & sbprp3 given in first source
proline-rich extensin-like receptor kinase 4, Arabidopsis: refseq nm_127403
proline-rich polypeptide-1, Bos taurus: has both antibacterial and neuroprotective activity; a fragment of neurophysin-vasopressin-associated glycoprotein
proline-rich protein, Arabidopsis: amino acid sequences of atprp1-atprp4 in first source
proline-specific dipeptidylcarboxypeptidase: from streptomyces species; removes diproline form c-terminus of proline-containing peptides such as boc-pro-pro-pro-pro or leu-pro-pro-pro-pro-pro
prolinedithiocarbamate: do not confuse with pyrrolidine dithiocarbamate which is also abbreviated pdtc
prolinium 4-(methylsulfinyl)butylglucosinolate: glucosinolate salt, from the flowering heads of cardaria draba (brassicaceae)
prolipyrone B: metabolite produced by overexpression of pks8 gene in fusarium graminearum
prolixicin, Rhodnius prolixus: has differential activity against bacteria and trypanosoma cruzi
prolonium: for treatment of hyperthyroidism; rn given refers to diiodide
proloteston: mixture of dromostanolone & its propionate, capronate, enanthoate esters
prolyl T RNA synthetase: minor descriptor (75-84); on-line & index medicus search amino acyl t rna synthetases (75-84)
prolyl hydroxylase domain protein 2, rat: refseq xm_002728611
prolyl tri-tetra-peptidyl aminopeptidase, Streptomyces mobaraensis: a prolyl peptidase that removes the tetra-peptide of pro-transglutaminase from streptomyces mobaraensis mycelia, thus involved in its maturation; amino acid
prolyl-4-hydroxyproline: php in non-hydrolyzed morning urine may be marker in postmenopausal osteoporosis
prolyl-arginyl-glycinamide: protective against puromycin-induced amnesia in mice; rn given refers to parent cpd
prolyl-aspartyl-histidyl-histidyl-methionyl-methionyl-tyrosyl-phenylalaninamide: a cardioinhibitory peptide; produces dose-dependent decreases in both amplitude and rate of heart contractions
prolyl-glycyl-alanyl-isoleucyl-prolyl-glycine: a repeated hexapeptide of bovine tropoelastin; a ligand for the 67-kda bovine elastin receptor
prolyl-glycyl-valyl-threonyl-alanyl-valine: a beta-sheet breaker that suppresses toxicity of alpha-synuclein aggregates
prolyl-histidyl-seryl-arginyl-asparagine: a synergy ligand derived from the ninth type iii domain of fibronectin
prolyl-leucyl-alanine hydroxamic acid: rn given refers to the mono-hcl
prolyl-leucyl-asparagyl-prolyl-lysine: effective against gbm-nephritis
prolyl-leucyl-glycyl-leucyl-alanyl-alanyl-arginyl-lysine: used to measure matrix metalloprotease activity
prolyl-leucyl-leucyl-glutaminyl-alanyl-threonyl-leucine: a synthetic antiangiogenic peptide that binds fibroblast growth factor
prolyl-leucyl-leucyl-glutaminyl-lysine: derived from donkey serum albumin
prolyl-leucyl-psi(methylamino)glycinamide: the product resulting from reduction of the leucine-glycine peptide bond in the tripeptide pro-leu-gly-nh2
prolyl-leucyl-thiazolidine-2-carboxamide: rn given refers to cpd without isomeric designation
prolyl-lysyl-glutamyl-lysine: a dermatologic agent with skin-lightening activity
prolyl-lysyl-glycinamide: protective against puromycin-induced amnesia in mice; rn given refers to (l-pro-l-lys)-isomer
prolyl-phenylalanyl-Aph-seryl-valyl-glycinamide: a tissue kallikrein inhibitor; amino acid
prolyl-phenylalanyl-N-heptylargininamide: rn given refers to (d-pro-l-phe-l-arg)-isomer
prolyl-phenylalanyl-arginine chloromethyl ketone: do not confuse with ppack (phe-pro-arg-ch2-cl) or with phe-phe-arg-ch2-cl
prolyl-phenylalanyl-arginine naphthylester: synthetic substrate for kallikrein
prolyl-phenylalanyl-arginine-4-methylcoumaryl-7-amide: fluorogenic substrate
prolyl-phenylalanyl-arginine-4-nitroanilide: chromogenic cpd
prolyl-phenylalanyl-arginyl-phenylalaninamide: a putative neuropeptide ff agonist
prolyl-phenylalanyl-psi(PO2CH2)-leucyl-prolinamide: neurolysin inhibitor
prolyl-phenylalanyl-valyl-tyrosyl-leucyl-isoleucine: a cell penetrating peptide
prolyl-prolyl-alanine: rn & n1 from 9th ci form index; rn given refers to (all-l)-isomer
prolyl-psi(methylamino)leucyl-glycinamide: the product resulting from reduction of the peptide bond between proline and leucine in the tripeptide pro-leu-gly-nh2
prolyl-seryl-glycyl-phenylalanyl-tyrosyl-leucyl-lysyl-leucyl-aspartyl-prolyl-arginyl-asparaginyl-phenylalanyl-asparagine: the "scrambled" trap peptide
prolyl-threonyl-glutamyl-phenylalanyl-4-nitrophenylalanyl-arginyl-leucine: synthetic chromogenic substrate for pepsin
prolyl-valyl-methionyl-glycyl-aspartic acid: isolated from oyster protein hydrolysate
prolylarginine: fragment of tuftsin peptide with analgesic action; rn given refers to all l-isomer
prolylleucine: rn given refers to (d-leu-l-pro)-isomer
prolylvaline: rn given refers to (l-pro-l-val)-isomer
prom protein, Drosophila: 910 amino acid residues; acts together with spacemake to choreograph the partitioning of rhabdomeres into an open system; refseq nm_001144281
promagainin protein, Xenopus: both magainins & spacer peptides obtained from the precursor have antimicrobial activity
promalabaricone B: acylphenol from fruit rind of myristica malabarica lam
promegapoietin-1a: an engineered chimeric il-3 variant - daniplestim (c093340) and mpl-l receptor agonist
promethin protein, mouse: up-regulated in ppargamma1-induced adipogenic liver; genbank ay167031
promothiocin A: mol form c36-h37-n11-o8-s2
promothiocin B: mol form c42-h43-n13-o10-s2
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein: selectively expressed in acute promyelocytic leukemia cells; recognized by t lymphocytes; amino acid sequence given in first source; product of a functionally altered retinoic acid receptor alpha gene
pronethalol: was heading 1964-94 (prov 1964-66); naphthylisoproterenol was see pronethalol 1977-94; use ethanolamines to search pronethalol 1966-94
proneuropeptide Y: proneuropeptide y is posttranslationally processed to npy(1-36)amide (neuropeptide y) & the c-terminal flanking peptide of npy which contains 30-amino acid residues; has been sequenced; see also record for preproneuropeptide y
proneurotensin: pront-nmn is a precursor for both neurotensin and neuromedin n
pronqodine A: regulates prostaglandin release from human synovial sarcoma cells
prontalgine: combination of paracetamol, amobarbital, dimethyl-n-octyl(beta-benzoylethyl)ammonium bromide, codeine phosphate & caffeine
pronuciferine N-oxide: a proaporphine n-oxide alkaloid from berberis coletioides
proopiocortin fragments: precursor molecule of acth & beta-lipotropin; see also record for msh pro-gamma-
prop-2-yn-1-yl 2-amino-6-(4-aminophenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate: has antineoplastic activity
propagermanium: inhibits the calcium inward currents & the potassium outward currents
propan-2-ol dehydrogenase (NAD): utilizes nad but not nadp as electron acceptor in oxidation to propanone
propan-2-yl 4-(6-(4-(2,5-difluorophenoxy)-3-hydroxybut-1-en-1-yl)-7-hydroxyoctahydro-2H-cyclopenta(b)oxepin-3-yl)butanoate: a prodrug of ono-ag-367
propane-2-nitronate: ; the ionic tautomer of 2-nitropropane
propane-2-sulfonic acid (2-(4-iodophenyl)cyclopentyl)amide: an iglur4 flip receptor potentiator
propapain: mw 39 kda; inhibited by a variety of cysteine protease inhibitors
propargyl alcohol: irreversibly inactivates alcohol oxidase; rn given refers to parent cpd
propazine: relatively non-toxic triazine herbicide; minor descriptor (75-82); online & index medicus search triazines (75-82)
propen-2-yloxirane: forms adducts with 2'-deoxyadenosine
propenediester lipid: endocannabinoid-like lipid from marine cyanobacteria
propeptin: prolyl endopeptidase inhibitor; isolated from microbispora; amino acid
propham: minor descriptor (72-85); on-line & index medicus search herbicides, carbamate (72-85); rn given refers to parent cpd
prophenin 1: a proline- and phenylalanine-rich antimicrobial peptide; mw 8,683 da; has 79 amino acid residues; its n-terminal 60 residues consists of 3 perfect and 3 nearly perfect repeats of a decamer fpppnfpgpr; amino acid sequence given in first source
prophospholipase A2: activated by plasmin to produce the receptor-binding form of phospholipase a2-i
propidium monoazide: a membrane impermeant dye that can cross-link dna
propildazine: rn given refers to parent cpd; synonym isf 2123 refers to di-hcl
propinox: used as premedication when performing endoscopic retrograde cholangiopancreatography (ercp)
propiomazine: was heading 1966-94 (prov 1966-72); use phenothiazines to search propiomazine 1966-94; phenothiazine derivative used for sedation and as an antiemetic during labor
propionate-3-nitronate oxidase: from penicillium atrovenetum; flavoprotein; catalyzes the oxidation of 3-nitropropionate in the presence of oxygen to yield malonate semialdehyde, no2, no3 & h2o2
propionic acid (9R,10R)-9-acetoxy-8,8-dimethyl-9,10-dihydro-2H,8H-benzo(1,2-b-3,4-b')dipyran-2-one-10-yl ester: from prionosciadium watsoni (umbelliferae)
propionicin PLG-1: produced by propionibacterium thoenii; mw 10 kda; heat labile, sensitive to several proteolytic enzymes & stable at ph 3 through 9
propionicin SM1: isolated from propionibacterium jensenii df1; amino acid
propionin B: propionins a, b & c isolated from propionibacterium freudenreichii; active against columbia sk virus & encephalomyocarditis virus
propionyl CoA carboxylase (ATP-hydrolyzing): deficiency results in propionic acidemia; see also propionyl-coa carboxylase (ec 4.1.1.41)
propionyl CoA hydrolase: nadh sensitive; found in brown adipose tissue mitochondria of rat; prevents a deterimental increase of propionyl-coa in mitochondria; mw at least 240 kda
propionyl-N-oxysuccinimide: used to isotopically label peptides
propionylcholinesterase: aspect of cholinesterase ec 3.1.1.8
propionylmaridomycin: synthetic macrolide antibiotic; 9-propyl ester of maridomycin isolated from streptomyces hygroscopicus
propionylshikonin: a skikonin derivative from roots of lithospermum erythrorhizon
propipocaine: rn given refers to parent cpd; synonyms falicaine & uricomb refers to hcl
propiram: rn given refers to parent cpd; synonym bay 4503 refers to fumarate[1:1]; practically always used as fumarate in medicine
propisomide: rn from toxline; rn not in chemline 8/85
propizepine: rn given refers to parent cpd; synonym up 106 refers to hcl
proplasmepsin II: zymogen of plasmepsin ii (ec 3.4.23.39); crystallographic structure and amino acid
propofan: contains propoxyphene, acetaminophen, aspirin, chlorpheniramine, & caffeine
propofol hydroxypropyl-beta-cyclodextrin: a propofol inclusion complex
propoxate: rn given refers to (+-)-isomer; rn for cpd without isomeric designation not avail 3/90
propranolol N-desisopropylase: liver microsomal enzyme containing cytochrome p-448
proprotein convertase PC7: a subtilisin/kexin-like serine proteinase with a cleavage specificity resembling that of hfurin; mw 89 kda; has been sequenced
propyl 1-ethyl-8-oxo-3-phenyl-5,6,7,8-tetrahydro-7-thiaisoquinoline-4-carboxylate: a3 adenosine receptor antagonist
propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate: an herbicide for use on rape crops
propyl 5-(3-(4-methoxyphenyl)ureido)pyrazine-2-carboxylate: has antimycobacterial properties
propyl 5-(3-phenylureido)pyrazine-2-carboxylate: has antimycobacterial properties
propyl O-(3,6-di-O-methyl-beta-glucopyranosyl)-(1-4)-O-(2,3-di-O-methyl-alpha-rhamnopyranosyl)-(1-2)-3-O-methyl-alpha-rhamnopyranoside: trisaccharide portion of the major serologically active glycolipid from mycobacterium leprae
propyl acetate: affects aggression without affecting motor activity; rn given refers to parent cpd
propyl alpha-ristotetraoside: heterotetrasaccharide component of ristomycin a (ristocetin a)
propyl beta-carboline-3-carboxylate: binds specifically to brain benzodiazepine receptors
propyl thiosulfinate oxide: has both antimicrobial and antioxidant activities; isolated from allium
propyl-3-sarcolysin-4-fluorophenylalanine: a component of peptichemio; sarcolysin is a phenylalanine derivative and not related to lysine
propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate: bacteriostatic agent against mrsa that appears to act via a novel mechanism
propylamycin: semisynthetic 4,5-deoxystreptamine class aminoglycoside
propylene glycol alginate ester: used to coat potential column supports for the preparation of water-insoluble immunoadsorbents
propylene glycol alginate sodium sulfate: has both anticoagulant and hypotensive activities
propylene glycol dinitrate: major volatile constituent of otto fuel ii liquid propellant that causes vasodilation, lowered blood pressure, methemoglobin formation; monoamine oxidase inhibitor
propylene glycol methyl ether: rn given refers to unspecified methoxypropanol
propyleneglycol dipelargonate: used as solvent to mimic the lipidic end of phospholipids present in the lipid bilayer
propylguanidine: side chain of arginine; rn given refers to parent cpd
propylhexedrine: was heading 1976-94 (see under propylamines 1976-90); use propylamines to search propylhexedrine 1976-94; alpha-adrenergic stimulant used extensively in nasal decongestant inhalers
propylparaben: rn given refers to cpd with hydroxy group locant in position 4
propylsulfonic acid: rn given refers to cpd without locant for propyl moiety
propylure: pheromone of pink bollworm moth; rn given refers to (e)-isomer
propylxanthate: inactivates cytochromes p450 2b1 and p450 2b6 in a mechanism-based manner
prorenin Ren2 converting enzyme: consists of two peptide chains mw 17 & 10 kda; isoelectric point between 7.5 & 8.5; cleaves peptide bond on carboxyl side of arg at the lys-arg pair of mouse ren2 prorenin, but does not cleave mouse ren1 prorenin & human prorenins; see also record for prorenin processing enzyme (a cysteine proteinase)
prorenin processing enzyme: accurately processes prorenin to active renin; see also record for prorenin ren2 converting enzyme (a serine proteinase)
proricin: contains an alternative protease-sensitive linker sequence; amino acid sequence has been determined
prorocentrol: was isolated from cultured cells of the dinoflagellate prorocentrum hoffmannianum
prorocentrolide B: a toxin from the tropical dinoflagellate prorocentrum maculosum faust
pros protein, Drosophila: amino acid sequence given in first source; expressed in ganglion mother cells of drosophila prospero; contains a homeodomain-like sequence
prosaposin receptor: a g-protein-associated receptor from baboon brain membranes; nw about 55 kda
prosecretin: preprosecretin is an n-terminally 9-residue elongated form of secretin; amino acid sequence given in first source
prosemin protein, human: normally expressed primarily in the pancreas, plus in the brain and prostate; expressed in a variety of cancers; amino acid
prosomatostatin: see also preprosomatostatins: 75037-28-4
prosopilosidine: isolated from prosopis glandulosa var. glandulosa; showed in vivo antimalarial activity
prospan: extract from hedera helix with bronchosecretolytic & antitussive qualities
prosparol: long-chain fatty acid & triglyceride lipid preparation used as oral lipid load
prosplen: lyophilized fresh spleen, free from histamine, choline, protein & lipoids for alleviating symptoms associated with allergies & polycythemia
prostacyclin synthesis stimulating plasma factor: non-cellular component in human blood, which is able to influence the prostacyclin formation to a certain degree
prostaglandin A2: rn given refers to (5z,13e,15s)-isomer
prostaglandin A2 isopropyl ester: potent ocular hypotensive agent; rn given refers to (5z,13e,15s)-isomer
prostaglandin B2: rn given refers to (5z,13e,15s)-isomer
prostaglandin D2 receptor: gpr44 is expressed on human t lymphocyte subsets during early pregnancy; refseq nm_009962 (gpr44, mouse); nm_004778 (gpr44, human); nm_022241 (ptgdr2, rat); nm_008962 (ptgdr, mouse); nm_000953 (ptgdr, human)
prostaglandin E1 monooxygenase: requires nadph; liver microsome enzyme is cytochrome p-450 dependent; catalyzes omega hydroxylation
prostaglandin E1-alpha-cyclodextrin: complex of alpha-cyclodextrin and pge1; used in treatment of serum sickness
prostaglandin F-main urinary metabolite: urinary metabolites of pgf2alpha in rats
prostaglandin F1: was en to prostaglandins f (75-81); rn given refers to (9 alpha,11 alpha,13e,15s)-isomer
prostaglandin F1beta: rn given refers to (9 beta,11 alpha,13e,15s)-isomer
prostaglandin F2 receptor negative regulator, mouse: refseq nm_011197
prostaglandin F2beta: rn given refers to (5z,9 beta,11 alpha,13e,15s)-isomer
prostaglandin R2 D-isomerase: prostaglandin d synthase and pgd synthase were non-print entry terms to prostaglandin synthase 1983-91; beta trace protein was mh 1977-92 (see under beta globulins 1977-90); use beta-globulins to search beta trace protein 1977-92
prostaglandin endoperoxide thromboxane isomerase: converts prostaglandin h2 to thromboxane b2 & 12l-hydroxy-5,8,10-heptadecatrienoic acid
prostaglandin reductase-3, mouse: catalyzes the conversion of 15-keto-pge2 to 13,14-dihydro-15-keto-pge2
prostaglandin-E2 9-reductase: catalyzes reversibly an nad+ dependent oxidation of the 9alpha-hydroxyl group of 15-keto-13,14-dihydro-pgf2alpha to 15-keto-13,14-dihydro-pge2; also acts on pga1; sequence data indicates that it is identical with carbonyl reductase (nadph) (ec 1.1.1.184)
prostaglandin-F synthase: catalyzes conversion of pgd2 to pgf2alpha; also converts pgh2 to pgf2alpha
prostaglandin-ICI 74205: has two more carbons on lower side chain than pgf2alpha; rn given refers to (3s*)-isomer
prostaglandin-generating factor of anaphylaxis: oligopeptide released from human lung parenchymal tissue during anaphylaxis
prostaglandin-inositol cyclic phosphate: inhibits glucose-stimulated insulin secretion in isolated islets of hamsters; primary constituents are prostaglandin e, myo-inositol & phosphate
prostasin: localized in oocyte, granulosa cells, and theca cells of early antral follicles and antral follicles; mouse cap1 is catalytically inactive
prostate apoptosis response-4 protein: induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase c; do not confuse with protease-activated receptor 4; refseq nm_002583 (human); xm_125814 (mouse); nm_033485 (rat)
prostate cancer antigen 3, human: target for therapy in prostate cancer; dd3/pca3 is a highly prostate cancer-specific gene; has been sequenced
prostate-specific antigen (146-154): used to induce specific t cell immunity for psa
prostatic acid phosphatase (248-286), human: forms amyloid fibrils, call sevi (semen-derived enhancer of virus infection), that trap hiv virions and enhance infectivity
prostatilen: drug obtained from the prostate of cattle; possesses an antiinflammatory, antibacterial, immunomodulating effect, improves urination, stimulates the copulative & generative functions; used for treatment of prostatitis in man
prostenoic acids: carbon-20 cyclic unsaturated fatty acids; the parent cpds of some unsaturated prostaglandins; minor descriptor (75-84); on-line & index medicus search fatty acids, unsaturated (75-84)
prostratin: rn given refers to the (1ar-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9aalpha))-isomer
prostromelysin: precursor of stromelysin; metalloendopeptidase
prosubtilisin: 77 amino acid residue peptide extension; found between the signal peptide and mature subtilisin
prosystemin protein, Lycopersicon esculentum: amino acid sequence given in first source; a 200 amino acid precursor protein of systemin; from lycopersicon esculentum (tomato)
protaetiamycine protein, Protaetia brevitarsis: isolated from the beetle named above
protamine +18RGD: a protamine variant that effectively reverses heparin anticoagulation without toxicity
protamine B, Acipenser gueldenstaedtii: see also sturin and stellin
protamine P2: contains 2 components; p2a with 57 amino acids whose sequence is given in first source, and p2b with 54 amino acids
protamine P2 precursor: almost twice as long as mature protein; amino acid has been determined
protamine P3: differs from protamine p2 only by three amino-terminal amino acids; amino acid sequence given in first source
protamine P4: minor basic protein of human sperm nuclei; amino acid sequence given in first source
protamine R3: from ratfish, hydrolagus colliei; amino acid sequence given in first source
protamine St1: mw appx 6600; 49 amino acid residues; from stallion sperm nuclei
protamine Z1: from dog-fish scylliorhinus caniculus; nucleotide sequence given in first source; corresponds to a 50-amino acid protein
protamine Z2: cysteine-rich protamine from dogfish (scylliorhinus caniculus)
protamine Z3: dog-fish protamine; contains 37 amino acids; corrected amino acid sequence reported in this article
protamine heparin aggregate: formed in the lamina rara externa of the glomerular basement membrane after infusion of protamine & heparin; used to investigate the clearance mechanism
protamine-like protein III: a major protamine-like sperm nuclear basic protein from mussel, mytilus trossulus; amino acid sequence given in first source
protamylasse: a residual compound of industrial starch production that provides a suitable medium for large-scale cyanophycin production; contains amino acids, organic acids, sugars and ash (complete list in first source)
protax: a cephem prodrug of taxol, synthesized by substituting the c-3' position of cephalothin with 2'-(gamma-aminobutyryl)taxol
protease A, Crotalus basiliscus: from mexican west coast rattlesnake; mw 24,200; inactivates alpha 2-macroglobulin; has no thrombin-like activity
protease B, Euphorbia supina: n-terminal amino acid ; 6 residues match those of cucumisin
protease C: n-terminal domain is homologous to proteases a, b, and e; c-terminal domain is homologous to chinin-binding domains of chitinases a1 and d
protease C1: hydrolyses alpha and alpha' subunits of beta-conglycinin; isolated from germinating soybeans; specific for glu or asp residues
protease Ci: a cytoplasmic metalloendoprotease; from escherichia coli; preferentially degrades relatively small polypeptides such as insulin; similar to protease pi
protease D, Streptomyces griseus: has a primary specificity for substrates with large aliphatic and aromatic side chains; amino acid sequence given in first source; genbank l29019
protease D, honeydew melon: serine protease from honeydew melon, similar to cucumisin except it has greater stability at high temperatures, wide ph range and stability in urea or guanidine hcl
protease I, Pyrococcus furiosus: a homooligomeric protein consisting of 18.8-kda subunits; ph1704 and pfpi are 90% identical; amino acid sequence of 18.8-kda subunit given in first source
protease I, Rarobacter faecitabidus: yeast-lytic serine protease; has elastase-like substrate specificity, affinity for mannose & preferentially hydrolyzes the peptide bond of aliphatic amino acids
protease MCP-01, Pseudoaltermonas: a cold-adapted protease from deep-sea psychrotrophic bacterium pseudoaltermonas sp
protease N: from limulus amebocyte lysate; serine protease which acts on factor xa & thrombin substrate; not active on substrates cleaved by plasmin, kallikreins or urokinase
protease PACE4C: a member of kexin family of proteases; specifically expressed in b cells of pancreatic islets
protease Q: subtilisin-like protease from bacillus pumilus; has 309 amino acid residues; n-terminal amino acid
protease Re: cleaves oxidized glutamine synthetase near the carboxyl terminus yielding 4,500 & 47,000 mr products; from e. coli, mw 75kda
protease S: similar to chymotrypsin in specificity; released on thermal injury to rat skin
protease SM: serratia marcescens metalloproteinase; its secretion in e coli is tolc dependent; its transporter consists of three proteins, two in the inner & one in the outer membrane
protease SPC7: spc - subtilisin-like proprotein convertase; spc4, spc6 & spc7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis; amino acid sequence given in first source; genbank u48830
protease V: from e coli membranes; has activity similar both to trypsin & chymotrypsin
protease VC-I: activates heat-labile enterotoxin from e coli by nicking at arg-192 of the n-terminus of the a subunit; specificity is similar to trypsin
protease activated kinase I: phosphorylates histones 2b & 4, eukaryotic initiation factors 3, 4b, 4s, ribosomal protein s10 & mysosin light chain; do not confuse with pak1, p53-activated kinase
protease inhibitor 16, mouse: antihypertrophic protein secreted from the heart and strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo; refseq nm_023734.3; np_076223.3
protease inhibitor protein, Phaseolus lunatus: inhibits trypsin and chymotrypsin
protease inhibitor, Bacillus brevis: amino acid sequence given in first source; isolated from bacillus brevis hpd31; has no significant homology to other protease inhibitors; does not contain any cysteine residues; do not confuse with bbrpi endonuclease
protease p29: an autocatalytic protease encoded by a hypovirulence-associated virus of the chestnut blight fungus; cleavage occurs between gly-248 & gly-249; amino acid sequence has been determined
protease resembling ICE: similar to interleukin-1 converting enzyme (ice); cleaves poly(adp-ribose)polymerase; involved in the active phase of apoptosis in vitro and in intact cells
protease, Moloney murine leukemia virus: more closely related to the hiv-1 protease than to the mouse mammary tumor virus enzyme, based on its substrate specificity & sensitivity to aspartyl protease inhibitors
protease-activated kinase II: cyclic nucleotide independent; incorporates up to 4 phosphates into ribosomal protein s6; phosphorylates initiation factor 2
protease-activated receptor 3: amino acid ; genbank u92972 (human) and u92971 (mouse)
protease-activated receptor 3, mouse: par-3 expression was demonstrated in mouse spleen & splenic megakaryocytes, suggesting that par-3 might mediate thrombin responses in mouse platelets; has been sequenced
protease-activated receptor 4: a 7 transmembrane g-protein-coupled receptor activated by thrombin and trypsin; mediates gastrointestinal motility; necessary for thrombin-induced procoagulant activity; do not confuse with prostate apoptosis response-4 protein; refseq nm_003950 (human); nm_007975 (mouse); nm_053808 (rat)
protease-activated receptor 4, mouse: par-4 mediates responses to high thrombin concentrations, analogous to the differential responses observed in mouse platelets; has been sequenced
proteasome 26S subunit, non-ATPase 6, human: refseq nm_001271779
proteasome alpha6 subunit, Drosophila: involved in pesticide deltamethrin resistance
proteasome component C5: mouse protein is 93% and 97.5% identical to human and rat c5 components, respectively; amino acid sequences of murine and rat forms in first source
proteasome subunit beta5t, mouse: involved in generating the mhc class i-restricted cd8(+) t cell repertoire during thymic selection (proteasome subunit beta5t)
proteasome subunit epsilon, Botryllus: isolated from the tunicate botryllus schlosseri; amino acid
proteasome subunit epsilon, Geodia: isolated from geodia cydonium; amino acid
proteasome, Thermoplasma: a 20s threonine protease (has thr at the amino terminal) from archaebacterium t. acidophilum; replacement of thr by ser allows full proteolytic activity; amino acid sequence given in first source
proteassemblin: a mammalian homolog of the yeast protein, ump1p, required for normal proteasome assembly; amino acid
protectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
protegrin-2: amino acid sequence given in first source; a cathelin-like protein isolated from porcine bone marrow
protein 1, Cardiochiles nigriceps polydnavirus: cardiochiles nigriceps polydnavirus protein from parasitized heliothis virescens larvae; amino acid ; genbank y19010
protein 22, Enterobacteria phage T4: protein 22 is a major prohead scaffolding core protein of 269 amino acid residues; amino acid sequence given in first source; nu3 has a mw of 13,396 kda whereas protein 22 has a predicted mr of 29.9 and a pi of 4.3
protein 2A, nepovirus: grapevine fanleaf nepovirus is implicated in rna2 replication and colocalizes to the replication site; has been sequenced
protein 30, Ehrlichia canis: detected in canine carrier blood and in individual experimentally infected ticks with a p30-based pcr assay; amino acid
protein 38, bacteriophage: acts as an adhesin for t-even type phage attachment to the host cell; amino acid sequence has been determined
protein 3A4, Heligmosomoides polygyrus: a recombinant version of a heligmosomoides polygyrus antigen that is preferentially recognized by resistant mouse strains; amino acid
protein 3B11: a cell surface protein from wing of manduca; partial amino acid sequence given in first source
protein 4.1 Presles: shortened variant of protein 4.1 (-8.5 kd)
protein 4.1B, human: meningioma tumor suppressor protein; has been sequenced
protein 60K, Chlamydia trachomatis: putative protein found between the trachoma & lymphogranuloma venereum biovars of c trachomatis; amino acid sequence given in first source; rn given is for product of strain c
protein 61, Varicella-zoster virus: exhibits limited amino acid similarity to hsv type 1 vmw110 protein; amino acid
protein 87kD, rat: a novel transporter-like protein localized to the cns; from rat brain; has been sequenced
protein 9, Aplysia: has sequence homology to stringent starvation protein (ssp) of escherichia coli; amino acid sequence given in first source
protein A24 lyase: releases histone 2a & ubiquitin from chromosomal protein a24
protein AG-gold complex: consists of staph protein a, streptococcal protein g & gold colloid; used as probe in immunocytochemistry; useful reagent in immunoblot analysis because of its ability to bind & identify nitrocellulose-immobilized igg
protein B (Pseudomonas putida): amino acid sequence given in first source; from pseudomonas putida strain ncib 12190; 11860 da
protein B23 antigenic peptide: from protein b23 after 30 min digestion with staphylococcal v8 protease; contains 68 amino acids; amino acid sequence given in first source
protein C (synaptosomal): found in synaptosomal plasma membrane; has actin-like effect; see records for c-protein, protein c & protein c (salivary)
protein C Nagoya, human: encoded by a gene with deletion of a single guanine residue (8857g) among four consecutive guanine nucleotides
protein C Osaka 1: arginine replaced by tryptophan at position 169 in the heavy chain; causes type i protein c deficiency
protein C Osaka 2: methionine is replaced by isoleucine at position 364 of the heavy chain; causes type i protein c deficiency
protein C Osaka 3: glycine is replaced by arginine at position 385 of the heavy chain; causes type ii protein c deficiency
protein C Padua2, human: dysfunctional protein c variant with arg-1 to cys substitution
protein C Padua3: abnormal protein c due to a heterozygous g-->t transversion at position 1388 of the protein c (pc) gene which predicted the substitution of arg(-1) to a leu (pc(r-1l)), identified in a thrombophilic patient
protein C activator peptide: mw appx 1,400 dodecapeptide released from amino terminal of protein c heavy chain
protein C propeptide: pro-portion of the leader sequence is 24-amino acids in length; do not confuse with pre-portion which is 18 amino acids in length
protein C, Rouen: abnormal protein c; has low anticoagulant but normal amidolytic activities
protein CI, plum pox potyvirus: an rna helicase; amino acid sequence has been determined
protein CS23: two serines are substituted for two cysteines at positions 70 & 88 in fibroblast growth factor
protein CTC, Bacteria: homologous to n-terminal sequence of tl5 protein of thermus thermophilus; amino acid sequence given in first source
protein D, rat: associates with the sperm head; differs from protein e by the lack of the 4e9 epitope; has been sequenced
protein E, cuttlefish: isolated from nuclei of sperm cells; expressed during epididymal transit; isolated from the cuttlefish sepia officinalis; amino acid sequence given in first source; genbank p80304
protein E, rat: differs from protein d by the presence of the 4e9 epitope; amino acid
protein G4-11, rheumatoid arthritis: abnormal protein found in the plasma of patients with rheumatoid arthritis; mw appr. 160 kda
protein H, Streptococcus: amino acid sequence given in first source; bacterial cell wall protein with specific affinity for human igg fc
protein H16: a 70 kda sequence-specific single-stranded dna-binding protein from mammalian cell lines; partial amino acid sequence given in first source
protein I, intestinal: calcium-binding protein biochemically & immunologically related to the fibroblast 36-kda substrate of the rous sarcoma virus-encoded tyrosine protein kinase; consists of two subunits, mw 36,000 & 10,000
protein I-II, Streptococcus mutans: a pathogen-associated molecular pattern (pamp) from oral streptococci that have been identified in the joints of rheumatoid arthritis patients
protein I7, vaccinia virus: encapsidated within the virus core; 423-amino acid protein; thermolabile growth is attributed to an amino acid substitution of pro344 to leu; homologous to the type ii dna topoisomerase of s. cerevisiae; amino acid sequence has been determined
protein IEF SSP 9502: a member of the wd-40 family, a group of proteins having 40-aa repeats containing trp and asp; a putative human homolog of saccharomyces trp protein pwp1; amino acid sequence given in first source; genbank l07758
protein IIIa, Human adenovirus type 2: from human adenovirus 2 temp-sensitive mutant 112; nucleotide sequence 12308-14065 of dna; contains 585 amino acids
protein IIIa, Rhizobium leguminosarum: amino acid sequence given in first source; 36 kda; probably a porin from a sub-type covalently linked to the peptidoglycan; strong similarity with 2 porins of brucella abortus, omp2a and omp2b
protein Kau, Fab fragment: human monoclonal cold agglutinin (igm(k); amino acid sequence given in first source; rn given refers to the light chain
protein M (glycoprotein): single chain glycoprotein (mw 50,000) which exhibits procoagulant activity in the conversion of prothrombin to thrombin 7 factor x to factor xa
protein NH2-terminal asparagine deamidase: converts amino terminal asparagine to aspartic acid; from porcine liver; mw about 33 kda
protein O-mannose beta-1,2-N-acetylglucosaminyltransferase: mutations of this enzyme accompany muscle-eye-brain disease; genbank ab057356
protein O-mannosyltransferase: dol-p-man is mannosyl donor to oh group of threonine or serine residues in proteins in fungi; mutations on pomt1 lead to walker-warburg syndrome; refseq nm_013382 (pomt2, human); nm_153415 (pomt2, mouse); nm_007171 (pomt1, human)
protein Oms28, Borrelia burgdorferi: oms - outer membrane spanning; a 25 kda, 257 amino acid residues protein from borrelia burgdorferi; genbank u61142
protein P10, bacteriophage phi6: may be involved in the translation of gene 6 & in host lysis; has been sequenced
protein P12, bacteriophage phi6: a non-structural protein required for phage membrane assembly; amino acid sequence known
protein P2, rice dwarf phytoreovirus: involved in the transmission of virus by the insect vector; partial amino acid sequence given in first source
protein P3, bacteriophage PRD1: a major capsid protein of 395 amino acid residues; amino acid sequence has been determined
protein P3, grapevine fanleaf virus: rna-encoded protein in infected chenopodium quinoa plants; amino acid sequence has been determined
protein P4 (Pseudomonas): component of the double-stranded rna bacteriophage phi 6; mw 35 kda; possesses nucleoside triphosphate phosphohydrolase activity; it is accessible on the nucleocapsid surface; amino acid sequence has been determined
protein P4, Manduca: mw 48 kda; hemolymph glycoprotein from manduca sexta; produced in response to bacterial infection; amino acid sequence has been determined
protein P5, Pseudomonas phage phi 6: has been sequenced; an endopeptidase which splits the peptide bridge formed by meso-diaminopimelic and and d-alanine in bacterial peptidoglycans
protein P5, bacteriophage PRD1: an essential protein that connects the receptor binding protein to the vertex; amino acid sequence known
protein P9, bacteriophage phi6: a phage membrane-associated protein; amino acid sequence known
protein PVC2, maize stripe virus: a 94 kda protein; amino acid sequence known
protein Ph1771, Pyrococcus horikoshii: archaeal ribonuclease p protein ph1771p from pyrococcus horikoshii ot3; an archaeal homolog of eukaryotic ribonuclease p protein rpp29; pdb iv76
protein S Heerlen: has ser460pro mutation which does not affect its apc-cofactor and apc-independent anticoagulant activities
protein S Tokushima: abnormal protein s found in a japanese family with thrombosis; has molecular defect on the carboxyl-terminal side of the thrombin sensitive site; see also thrombin tokushima & prothrombin tokushima
protein S precursor: consists of a 41 amino acid leader peptide followed by 635 amino acids corresponding to mature protein s
protein S receptor, mouse: binds to lymphocytes, promotes aggregation and inhibits proliferation
protein S, Myxococcus xanthus: development specific protein of myxococcus xanthus; produced during fruiting body formation; has been well characterized; do not confuse with record for protein s from human blood
protein U, Myxococcus: late developmental spore coat protein of myxococcus xanthus; secretory protein; amino acid sequence given in first source
protein W, Myxococcus: spore-specific protein isolated from myxococcus xanthus; amino acid
protein W, bacteriophage lambda: the head-tail joining protein; genbank p03727
protein X, Woodchuck hepatitis B virus: rn refers to strain new york; amino acid sequence has been determined
protein YL10, Chironomus tentans: amino acid sequence has been determined; 240 amino acid residues, mw 24,213; 65% homologous to yeast and 71% homologous to human protein; from dipteran, chironomus tentans
protein Z alpha 4: designed protein that contains a cys2his2 zinc(ii)-binding site
protein Z, Avena fatua: accumulates during seed development of oat, a fatua; homologous to barley protein z, an allergen in beer; amino acid ; genbank af118559-60 (a. fatua)
protein acyl kinase: transfers gamma-phosphate of atp to a protein acceptor with formation of an acyl phosphate bond
protein acyltransferase: human placental enzyme active in posttranslational acylation of membrane glycoproteins
protein antigen b, Mycobacterium: amino acid sequence given in first source; involved in phosphate metabolism
protein complex B800-850, Rhodobacter: pigment-protein complex found in light-harvesting apparatus of purple non-sulfur photosynthetic bacteria rhodopseudomonas capsulata & acidophila
protein complex B806-866, Chloroflexus aurantiacus: pigment-protein complex found in light-harvesting apparatus of green thermophilic bacterium chloroflexus aurantiacus; consists of two polypeptide chains
protein disulfide isomerase-3, C elegans: also has transglutaminase-like cross-linking activity; involved in maintaining body morphology
protein disulfide oxidoreductase, Methanococcus jannaschii: from hyperthermophilic m. jannaschii; partial amino acid  c
protein disulfide oxidoreductase, P. furiosus: hyperthermophilic enzyme from the archaeon, pyrococcus furiosus has two thioredoxin fold units; amino acid sequence and x-ray crystallography in first source
protein kinase A Calpha: an isoform of the catalytic subunit of pka
protein kinase A Cgamma: an isoform of the catalytic subunit of pka
protein kinase C eta: has been sequenced; a member of the novel protein kinase c family, which is calcium-independent
protein kinase C gamma: calcium-dependent isoenzyme of protein kinase c; mutation of pkcgamma can lead to spinocerebellar ataxia type 14 (sca14); amino acid sequence has been determined
protein kinase C lambda: member of the third class in the protein kinase c family; 72% identity with pkc zeta; expressed dominantly in undifferentiated mouse embryonal carcinoma cell line & also in many tissues & cells; genbank d28577 (mouse); refseq nm_002740 (human), nm_008857 (mouse)
protein kinase C nu: member of the protein kinase c family that composes a subfamily with pkcmu; amino acid ; genbank ab015982
protein kinase C zeta: induces phosphorylation & inactivation of ikappab-alpha in vitro; the zeta isotype of pkc is unable to bind phorbol esters, required during the nf-kappab activation as well as in mitogenic signalling in xenopus oocytes & mammalian cells; has been sequenced
protein kinase C zeta II, mouse: member of the atypical protein kinase c (apkc) family & an endogenous inhibitor of cell polarity; mw 45 kda; genbank m94632
protein kinase C-binding protein Beta15, rat: member of the hit (histidine triad) family; refseq nm_021764
protein kinase CK42: binds single-stranded dna in chironomus cells; activity similar to that of casein kinase ii (ck2); 42kda
protein kinase D: a target for phorbol esters and diacylglycerols; an isoform of protein kinase c; refseq nm_002742 (human); nm_008858 (mouse); xm_234108 (rat); do not confuse with pkd1 protein, mouse
protein kinase III: calcium-dependent kinase that does not require calmodulin; isolated from the mango mangifera indica
protein kinase N: homologous to protein kinase c; nerve growth factor-activated serine protein kinase that is active in the presence of mn++
protein kinase NI: aspect of ec 2.7.1.37; has distinct functions in cell nuclei
protein kinase NII: aspect of ec 2.7.1.37; phosphorylates basic non-histone proteins; cyclic nucleotide-independent
protein kinase P: requires a basic polypeptide for activity; mw 27kda-32kda from human spleen; phosphorylates endogenous & artificial substrates, stimulated by phosphatidyl inositol & phosphatidylglycerol
protein kinase PKV: 55-kda pkv (protein kinase viroid)-induced protein; amino acid ; genbank af143505
protein kinase U: pkualpha is a nuclear protein regulated by protein 14-3-3; amino acid
protein kinase inhibitor (6-22): a pka (cyclic amp-dependent protein kinase) antagonist
protein kinase inhibitor (6-22)-amide: camp-dependent protein kinase inhibitor; amino acid
protein kinase inhibitor M (6-24): stabler than pkip; amino acid sequence given in first source
protein kinase inhibitor peptide: 18 amino acid residues given in first source; corresponds to the inhibitory domain of the heat-stable protein kinase inhibitor
protein kinase modulator: stimulates phosphorylation of histones by mammalian cgpk & inhibits phosphorylation by capk; stimulates & inhibits protein kinase; see also records for pkibeta and pkigamma
protein kinase-phosphatase NTRB: amino acid sequence given in first source; refers to klebsiella pneumoniae; ntrb shows autophosphorylation
protein methylesterase: hydrolyzes protein methyl esters to yield methanol & unmethylated protein; found in bacterial & human cells
protein p10, African swine fever virus: amino acid sequence given in first source; exhibits strong dna binding activity
protein p12, African swine fever virus: amino acid sequence given in first source; involved in virus attachment to the host cell; expressed by the african swine fever virus
protein p14, classical swine fever virus: produced by autoproteolytic cleavage between csfv p23 & p14; mw 14 kda; amino acid sequence has been determined
protein p16, bacteriophage phi29: pumps dna into the viral prohead at the expense of atp
protein p16.7, bacterophage phi29: involved in phage dna replication; genbank m14430
protein p23: amino acid sequence given in first source; two amino acids in the sequence are not identified; has sequence homology to ribosomal protein yl43 from yeast; do not confuse with sperm acrosomal peptide p23
protein p37, African swine fever virus: amino acid sequence given in first source; major structural protein of african swine fever virus
protein p44, polydnavirus: the gene encoding the polydnavirus structural polypeptide is not encapsidated, rather resides in the genome of its associated wasp host; genbank af004366
protein p52, mammalian: a 52 kda protein that induces apoptosis & activates c-jun n-terminal kinase (jnk1); highly conserved in mammals; amino acid ; genbank af029071
protein p65, Beet yellows virus: a homolog of cellular heat-shock protein 70, coded in rna of beet yellows virus genome; partial amino acid sequence given in first source
protein p65, vaccinia virus: functions as an internal scaffold in the formation of viral crescents & immature virions; mw 65 kda; amino acid sequence has been determined
protein p80: non-glycosylated phosphoprotein; tumor-related antigen of mouse lymphoma
protein phi 0, Holothuria tubulosa: amino acid sequence given in first source; histone to protamine transition protein from sea cucumber spermatozoa
protein phosphatase 3, catalytic subunit, beta isoform, mouse: refseq nm_008914
protein phosphatase 4: a serine/threonine phosphatase localized to mammalian centrosomes; ppp4 is the human genome nomenclature; amino acid sequence given in first source
protein phosphatase 5: an estrogen-inducible phosphatase that has 4 tetratricopeptide repeat (tpr) motifs; similar to ppt1 protein; do not confuse with the placental protein pp5; amino acid sequence given in first source
protein phosphatase 6: human serine/threonine phosphatase that is functional homologue of budding yeast sit4p and fission yeast ppe1; genbank x92972
protein phosphatase inhibitor-1: 16-18 kda heat-stable protein which inhibits phosphorylase phosphatase in skeletal muscle & other tissue; inhibitor of protein phosphatase after it has been phosphorylated by cyclic amp-dependent protein kinase; genbank z50748 (bos taurus); refseq nm_146154 (mouse)
protein phosphatase inhibitor-1, rat: protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes. vernacular title:
protein phosphatase inhibitor-2: reversibly inhibits phosphorylase phosphatase without prior phosphorylation; protein isolated from rabbit muscle; identified as a atp-mg dependent protein phosphatase modulator; genbank aj249461-2 (drosophila), l20858 and m95581 (o. cuniculus), s79213 (rat); refseq nm_006241 (human)
protein phosphatase inhibitor-4: inhibitor of human type 1 protein phosphatase (pp1) ; amino acid sequence shows 44% homology to that of protein phosphatase inhibitor-2 ; genbank ab044137
protein phosphatase methylesterase-1: demethylates protein phosphatase 2a catalytic subunit (pp2a c subunit); amino acid
protein tyrosine kinase Pyk2-H: isoform of pyk2 generated by alternative rna splicing; expressed primarily in hematopoietic cells; amino acid sequence has been determined
protein tyrosine phosphatase, non-receptor type 11, a, zebrafish: refseq nm_199846
protein-N-pi-phosphohistidine - sugar phosphotransferase: enzyme ii of the system; leve is the the iib subunit from bacillus subtilis;
protein-S-isoprenylcysteine O-methyltransferase: methylates carboxyl-terminal cysteine of eukaryotic proteins; c-terminal s-geranylgeranylcysteine and s-geranylcysteine residues are also methylated more slowly
protein-S-prenylcysteine methyl esterase: may be two isoenzymes with this activity in bovine adrenal medulla
protein-bound polysaccharide K, Basidiomycetes: an extract derived from basidiomycetes mushrooms; used as a biological response modifier in treatment of epithelial cancer
protein-deamidating enzyme, Chryseobacterium: a 20 kda protein-deamidating enzyme from chryseobacterium proteolyticum, a bacterium isolated from soil; the enzyme catalyzed the deamidation of native caseins with no protease and transglutaminase activities; genbank ab039830
protein-tyrosine kinase p55(blk): member of the src family of non-receptor tyrosine kinases
protein-tyrosine phosphatase, Nostoc: amino acid sequence given in first source; isolated from the cyanobacterium nostoc commune utex 584; also acts on phosphoserine residues in proteins
proteinase Cpro-1, hepatitis C virus: cleaves hcv polyprotein p110 to generate n-terminal of p70; enzyme activity is unique hcv characteristic, different from other members of flaviviridiae; amino acid sequence has been determined
proteinase Cpro-2, hepatitis C virus: cleaves hcv polyprotein p110 to generate c-terminus of p70; similar to flaviviral proteinases with homologous catalytic domains; amino acid sequence has been determined