NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
fasamycin A: from streptomyces albus; show activity against methicillin-resistant s. aureus and vancomycin-resistant e. faecalis
fasamycin B: from streptomyces albus; show activity against methicillin-resistant s. aureus and vancomycin-resistant e. faecalis
fasciatoxin: from the venom of bungarus fasciatus; amino acid sequence given in first source
fasciclin I: mw 70k; membrane glycoprotein expressed on subset of axon fascicles during neuronal development of grasshopper; do not confuse with fatty acid synthetase complex which is also called fas
fasciclin II: mw 95k; membrane glycoprotein expressed on subset of axon fascicles during neuronal development of grasshopper; do not confuse with fatty acid synthetase complex which is also called fas
fascicularone A: isolated from the culture broth of a poisonous mushroom, naematoloma fasciculare
fascicularone B: isolated from the culture broth of a poisonous mushroom, naematoloma fasciculare
fasciculic acid A: ester of fasciculol a & 3-hydroxy-3-methylglutaric acid; calmodulin antagonist from mushroom naematoloma fasciculare
fasciculic acid B: ester of fasciculol b & 3-hydroxy-3-methylglutaric acid; calmodulin antagonist from mushroom naematoloma fasciculare
fasciculic acid C: calmodulin antagonist from mushroom naematoloma fasciculare
fasciculin: from green mamba dendroaspis angusticeps; has 61 amino acids, 4 disulfides; mw 6765 for fasciculin 1 and 6735 for fasciculin 2 with a probable difference of one amino acid
fasciculol E: lanostane-type triterpene toxic principle from poisonous mushroom naematoloma fasciculare (nigakuritake)
fasciculol F: lanostane-type triterpene toxic principle from poisonous mushroom naematoloma fasciculare (nigakuritake)
fascin: an actin cross-linking protein from a wide variety of organisms; amino acid sequence known; mw 53-58 kda; genbank x75938
fascioquinol E: inhibits cpsb phosphatase; isolated from the sponge fasciospongia
fasciospongine A: sulfated sesterterpene alkaloid from the marine sponge fasciospongia sp.
fasciospongine B: sulfated sesterterpene alkaloid from the marine sponge fasciospongia sp.
fasciospongine C: alkaloid from the marine sponge fasciospongia sp.
fasciospyrinadine: from a guangxi sponge fasciospongia sp.
fasinumab: a fully human igg4 mab that specifically binds mature and pro-nerve growth factor (ngf); in clinical trials for treatment of pain associated with osteoarthritis
fast cat: a fluorescent chloramphenicol derivative; used as a substrate for chloramphenicol acetyltransferase assays
fast corinth V salt: used for the detection of zeranol & estradiol in fortified plasma & tissue extracts; rn given refers to parent cpd
fastins: do not confuse with fastin, a synonym to phentermine.hcl; fastin i contains nitrofurazone 2%, (+-)-chloramphenicol 1.6%, benzocaine 3%, lanolin 39.2%, vaseline 18.7%, tristearin 6.5%, & water up to 100%; fastin ii is same except for replacement of tristearin with spermaceti (whale oil) 11.2%; ointments; for treatment of impetigo
fastuosain, Bromelia fastuosa: a cysteine peptidase from the fruits of bromelia fastuosa; amino acid
fasxiator, Bungarus fasciatus: factor xia inhibitor from snake venom
fat-1 protein, C elegans: n-3 polyunsaturated fatty acids (pufas); converts n-6 pufas to corresponding n-3 pufas; has been sequenced
fat-2 protein, C elegans: n-3 polyunsaturated fatty acids (pufas); converts n-6 pufas to corresponding n-3 pufas; has been sequenced
fat-3 protein, C elegans: deficiencies in c20 polyunsaturated fatty acids cause behavioral and developmental defects in caenorhabditis elegans fat-3 mutants; refseq nm_001268497.1
fat-specific protein 27, mouse: a lipid droplet protein that enhances triglyceride storage; refseq nm_178373.3; np_848460.1
fatty acid 2-chloroethyl ester synthase: catalyzes the formation of 2-chloroethyl esters of long-chain fatty acids; localized in the microsomal fraction of rat liver
fatty acid 2-hydroxylase 1, Arabidopsis: refseq nm_129030; do not confuse with fah1 protein, arabidopsis
fatty acid 2-hydroxylase 2, Arabidopsis: refseq nm_118205
fatty acid alpha-hydroxylase: enzyme from sphingomonas paucimobilis; catalyzes the alpha-hydroxylation of myristic acid in the presence of hydrogen peroxide
fatty acid chloromethyl ketones: used as inhibitors of acetoacetyl-coa thiolase, cholesterol biosynthesis and fatty acid synthesis
fatty acid methyltransferase: catalyzes the reaction of s-adenosylmethionine & a fatty acid to yield s-adenosylhomocysteine & a fatty acid methyl ester; calcium & calmodulin insensitive
fatty acid modifying enzyme: staphylococcus aureus enzyme inactivates bactericidal fatty acids by esterification to various alcohols
fatty acid oxidation complex: e. coli complex contains 3-ketoacyl coa thiolase (ec 2.3.1.16), 3-hydroxyacyl coa dehydrogenase (ec 1.1.1.35), enoyl-coa hydratase (ec 4.2.1.17), dodecenoyl coa delta-isomerase (ec 5.3.3.8) & 3-hydroxyacyl coa epimerase (ec 5.1.2.3)
fatty acid synthase I, mycobacteria: a single polypeptide with multiple catalytic domains; isolated from mycobacteria; see also fas-ii protein; unlike most other bacteria, mycobacteria make fatty acids with the multidomain enzyme eukaryote-like fatty acid synthase i
fatty acid, fat-soluble vitamin and phospholipid emulsion: high calorie fatty acids, fat-soluble vitamins and phospholipids
fatty acid-CoA racemase, Mycobacterium tuberculosis: from mycobacterium tuberculosis h37rv; an interlocked dimer with an unusual protein fold, and indicating that far has amino acid sequences that represent coa transferase family iii; converts several (2r)-branched-chain fatty acid-coa's to their (2s)-stereoisomers in the metabolism of fatty acids; refseq np_215370.1
fatty acid-binding protein 6: mw 14 kda; 127 amino acid residues given in first source; ileal protein which stimulates gastric acid and pepsinogen secretion
fatty acyl amidases: amidases i & ii act sequentially on lipopolysaccharides cleaving hydroxymyristyl groups
fatty acyl ethyl ester synthase: myocardial enzyme; esterifies free fatty acids in the absence of atp & coenzyme a; the fatty acid ethyl ester synthase iii has homology with glutathione s-transferase
fatty-acid amide hydrolase: degrades neuromodulatory fatty-acid amides including anandamide; inhibited by nsaids
faulkneryne A: from a bahamian sponge diplastrella sp.
faulkneryne B: from a bahamian sponge diplastrella sp.
faulkneryne C: from a bahamian sponge diplastrella sp.
faurine: a benzyl-aporphine dimer; from thalictrum fauriei
fazadinium: fazadinium bromide was heading 1991-94; was fazadinium see under pyridinium compounds 1979-90; was ah 8165 see under pyridinium compounds 1975-78; ah 8165 was see fazadinium bromide 1979-94; use pyridinium compounds to search fazadinium bromide 1991-94, fazadinium 1979-90 & ah 8165 1975-78; a rapid-acting, short-lasting, competitive nondepolarizing neuromuscular blocking agent; its action is rapidly and completely reversed by neostigmine
fbcS protein, Rhodovulum sulfidophilum: a 6-kda protein located in within the sox operon; amino acid
fbp1 protein, Petunia x hybrida: flower-specific gene product exclusively expressed in petunia petals and stamen; amino acid sequence given in first source; do not confuse with drosophila fat body protein 1 (fbp1)
fbp2 protein, Petunia x hybrida: gene product expressed from petals, stamen and carpels of petunia flowers; amino acid sequence given in first source
fbp3 protein, Petunia x hybrida: isolated from petunia; amino acid sequence given in first source; genbank x71417
fdhC protein, Methanobacterium formicicum: isolated from m. formicicum; amino acid ; identical protein in other bacterial species
febantel-praziquantel paste: combination of febantel & praziquantel
fecal antigen-1, normal: from normal adult feces; glycoprotein mw 20,000-30,000; related to but different from carcinoembryonic antigen; first 10 amino acid sequence different from cea; do not confuse with adhesin, e coli, which is also called nfa-1
fei-liu-ping: inhibits lung cancer growth and invasion by suppressing tumor inflammatory microenvironment. component herbs in first source
feifukang: herbal preparation consisting of astragalus membranaceus, codonopsis pilosula, ophiopogon japonicus, schisandra chinensis, panax notoginseng, bulbus fritillariae thunbergii, rhizoma anemarrhenae, and glycyrrhiza uralensis; used to treat pulmonary fibrosis and inhibits jak-stat signaling pathway
feigrisolide A: a lactone with antibacterial activities from streptomyces
feigrisolide B: a lactone with antibacterial activities from streptomyces
feigrisolide C: a lactone with antibacterial activities from streptomyces
feigrisolide D: a lactone with antibacterial activities from streptomyces
feleucin-BO1 peptide, Bombina orientalis: an antimicrobial peptide isolated from the toad bombina orientalis
feline leukemia virus protein p15E: mw 19,000; suppresses feline neutrophils in vitro
feline leukemia virus receptor: a 70 kda protein found on the surface of feline t cells; binds felv-a
feline leukemia virus vaccine: subunit vaccine composed of immunostimulating complex of proteins of felv envelope; leukocell contains inactivated felv proteins & cell membrane antigen
felinone A: antibacterial from beauveria felina en-135, a marine-derived entomopathogenic fungus
felinone B: antibacterial from beauveria felina en-135, a marine-derived entomopathogenic fungus
fellutamide A: tripeptide derivative from penicillium fellutanum; enhances nerve growth factor (ngf) synthesis and secretion in vitro
fellutamide C: from an metulocladosporiella (chaetothyriales)
fellutamide D: from an metulocladosporiella (chaetothyriales)
felzartamab: anti-cd38 monoclonal antibody in patients with relapsed or refractory multiple myeloma
fem-3 protein, C elegans: amino acid sequence given in first source; required for male development in nematode, c. elegans
fem-3-binding protein, C elegans: regulates sexual fates in the hermaphrodite germ line; amino acid
female protein, hamster: fast alpha globulin present in generous amts in sera of normal female syrian hamsters; functionally & structurally similar to c-reactive protein & serum amyloid p component
female protein, rat: a pentraxin with lectinic properties; closely related to hamster female protein
femoxetine: serotonin uptake inhibitor; rn given refers to (3r-trans)-isomer
fenamic acid: has chloride and potassium channel-blocking activity; rn given refers to parent cpd
fenchol synthetase: catalyzes cation-dependent cyclization of geranyl pyrophosphate & neryl pyrophosphate to the bicyclic rearranged endo-fenchol
fenclozic acid: an analgesic & antipyretic with anti-inflammatory properties; minor descriptor (75-86); on-line & index medicus search thiazoles (75-86); rn given refers to parent cpd
fend protein, Drosophila: involved in neuromuscular specificity in drosophila identified by gain-of-function screening; refseq nm_132300
fendleridine: first isolated in 1964 from the venezuelan tree aspidosperma fendleri
fenestrel: synonym orf-4563 refers to na salt; rn given refers to parent cpd
feneticillin: pheneticillin (feneticillin) is an oral acid resistant penicillin analogous to penicillin v with a range of antimicrob activity similar to penicillin g
fenfluthrin: synthetic pyrethroid used for insecticidal efficacy against mosquito vectors; rn given refers to cpd without isomeric designation
fengbaisan: for improving pulmonary function; consists of astragalus membranaceus, panax ginseng c.a. mey, lilium brownii, rhizoma polygonati, rhizoma dioscoreae, radix asteris, radix ophiopogonis, and radix salviae miltiorrhizae
fengycin synthetase: catalyzes activation of last amino acid in fengycin; also has a thioesterase domain; isolated from bacillus subitilis; genbank l42523
fenicoberan: experimental acid neutralizer in peptic ulcer; exhibits similar therapeutic effects as carbocholen in treatment of ischemic heart disease; exhibits antiarrhytmic properties in patients with extrasystolia; russian drug; rn given refers to hcl
fenitrothion phosphatase: from alcaligenes nc5, microbe from soil treated with fensulfothion; hydrolytically cleaves fensulfothion & structurally related organophosphorus cpds
fenix: organophosphate pesticide effective on a soil protist, colpoda inflata (ciliophora, colpodidae)
fennebricin A: from the south china sea nudibranch jorunna funebris and its possible sponge-prey xestospongia sp.
fennebricin B: from the south china sea nudibranch jorunna funebris and its possible sponge-prey xestospongia sp.
fenprostalene: rn given refers to (1r*,2r*,3r*,5s*)-(e)-(3r*)-isomer
fenspiride: was heading 1975-94 (see under spiro compounds 1975-90); use spiro compounds to search fenspiride 1975-94; bronchodilator agent used in asthma
fensulfothion: was mh 1972-92 (see under insecticides, organothiophosphate 1972-90); use organothiophosphorus compounds to search fensulfothion 1972-92
fentanyl isothiocyanate: specific reagent for irreversible inactivation of delta opiate receptors in rat brain membranes
fentiuram: combination of 40% tmtd (thiram) 20% hcch, 10% copper trichlorophenolate
fentonium: less effect on eye, heart & gland functions than atropine; proposed for therapy of gastrointestinal ulcers; minor descriptor (78-84); on-line & index medicus search atropine derivatives (78-84); rn given refers to bromide(3(s)-endo)-isomer
fenvalerate: synthetic pyrethroid; rn given refers to cpd without isomeric designation
feo protein, E coli: a member of the iron uptake system in e. coli; amino acid
fepB protein, E coli: amino acid sequence given in first source; periplasmic protein required for ferrienterobactin transport
fer1l6 protein, zebrafish: no refseq available; genbank:al929266
feral: russian drug; iron-albumin complex; rn given refers to cpd with unknown mf
fermenticin HV6b, Lactobacillus fermentum: reduces sperm motility also
fermt3 protein, Xenopus: expressed in hematopoietic lineages
fern-9(11)-en-3,19-dione: from the lichen pyxine berteriana
fernblock: has antioxidant and photoprotective activities; isolated from the aerial parts of polypodium leucotomos
feronielloside: furanocoumarin glycoside acetylcholinesterase inhibitor from roots of feroniella lucida
ferreascidin protein, Pyura stolonifera: dopa-containing iron-binding protein from pyura stolonifera
ferredoxin-NADP reductase-binding protein, Zea mays: has been isolated from pea, spinach, chlamydomonas and maize; mw about 17 kda; genbank z26824
ferredoxin-nitrite oxidoreductase: catalyzes reduction of nitrite to ammonia with reduced ferredoxin as electron donor
ferri-heme undecapeptide: corresponds to residues 11 to 21 of cytochrome c bound to ferriheme; has peroxidase activity; amino acid sequence in exp eye res 1997 oct;65(4):457-70
ferric ammonium citrate: rn given refers to unspecified nh4-fe(+3) salt
ferric chloride: rn given refers to cpd with mf of fe-cl3; used to induce experimental arterial thrombosis to evaluate antithrombotic agents
ferric citrate iron reductase: requires fmn, uses nadh; fre1 (genbank m86908) and fre2 (genbank z28220) provide membrane-associated ferric reductase activity for saccharomyces cerevisiae; most ferric reductases are flavin reductases (nad(p)h-flavin oxidoreductase) - biometals 7:3-8; 1994
ferric dihydrolipoate complex: major product of the anaerobic removal of ferritin-bound iron by dihydrolipoate at neutral ph; apoferritin takes up iron from above complex
ferric ferrocyanide: antidote to thallium poisoning; rn given refers to fe(+3)[3:4] salt
ferric gluconate: iron important in this cpd; rn given refers to ferric cpd
ferric hydroxide: additional rns for iron hydroxide oxide: 11115-92-7, 20344-49-4; rn for unspecified iron hydroxide: 11113-66-9
ferric iron-alcaligin E receptor, Ralstonia eutropha: isolated from alcaligenes eutrophus; amino acid ; genbank x97499
ferric leghemoglobin reductase: from cytosol of soybean root nodules; reduces ferric leghemoglobin to the ferrous state
ferric oxyhydroxide: an antiferromagnetic material; constitutes the core of natural ferritin; mol form 5fe2o3.9h2o
ferric subsulfate solution: styptic or hemostatic agent after superficial skin biopsis
ferric sulfate: rn given refers to fe(+3)[3:2] salt)
ferric uptake regulating proteins, bacterial: from e coli; mw 17 kda; transcriptional repressor of siderophore genes & operons; amino acid sequence has been determined
ferric-N-(3-phenylglutaryl)desferrioxamine B: ; mri contrast agent; rn from toxlit
ferric-adenosine triphosphate complex: model for ferritin & other polynuclear iron complexes with phosphate
ferrichrome synthetase: synthesizes ferrichrome; from aspergillus quadricinctus
ferrichysobactin receptor, Pectobacterium chrysanthemi: from erwinia chrysanthemi; amino acid sequence given in first source; genbank x87967
ferrineoaspergillin: produced by co-cultures of two marine-derived mangrove epiphytic fungi
ferripyochelin: involved in iron transport; during transport process, an energy-independent association of the cpd with bacteria occurs followed by an energy-dependent accumulation of iron
ferripyochelin-binding protein, Pseudomonas aeruginosa: mw 14k protein from cell envelopes of pseudomonas aeruginosa low iron grown cells
ferripyoverdine reductase: probably due to ec 1.6.8.1, nad(p)h dehydrogenase (fmn)
ferripyoveridine reductase: plays a role in the reductive release of iron from ferripyoverdine; isolated from pseudomonas fluorescens; inhibited by oxygen, requires nadh and fmn
ferristatin: a small-molecule iron transport inhibitor that promotes degradation of the transferrin receptor
ferristene: oral magnetic particles composed of a ferrite-type crystalline iron oxide bound to a monodisperse nonbiodegradable organic polymer particles; not absorbed by the gi tract & does not cause systemic toxicity
ferrithiocin: the ferric complex of desferrithiocin; cytotoxic
ferritin associated protein, human: isolated from liver and t lymphoid cells; plays a possible role in iron metabolism; genbank u63542
ferritin-concanavalin A conjugate: used to localize con a binding sites on rat cerebral cortex synaptosomes
ferritin-cyclohexyladenosine: a tool for localization of a1 adenosine receptors
ferritin-like protein, Listeria: the main cold shock protein of listeria monocytogenes belongs to the family of ferritin-like proteins; amino acid sequence known
ferro-manganese alloy: decreased glucose-6-phosphate dehydrogenase activity found in workers producing ferro-manganese alloys
ferroactinolite: non-asbestos mineral fibers containing silicon, iron, calcium, magnesium, manganese in order of decreasing amount; rn given refers to cpd with unknown mf
ferrocenopapain: formed by site-specific inactivation by reacting with chloroacetylferrocene
ferroceron: used in treatment of iron deficiency anemia & its relapses; structure; also used to measure iron reserves in the body
ferrocyn: a highly effective radiocaesium binder which reduces radiocaesium conatmination of animal products
ferropolysaccharide: embolic agent which contains dextran, carboxymethylcellulose, iron powder & meglumine iodamide
ferrostatin-1: inhibits ferroptosis, an iron-dependent form of nonapoptotic cell death
ferrous fumarate: used in treatment of iron deficiency anemia; rn given refers to fe(+2)[1:1] salt
ferrous gluconate: iron important in this cpd; rn given refers to ferrous cpd
ferrous succinate: rn given refers to fe(+2)(1:1) salt; important as iron supplement
ferrous sulfate: ferro-gradumet is ferrous sulfate in controlled release form; rn given refers to fe(+2)[1:1] salt
ferrous sulfate, mucin drug combination: contains 80 mg of ferrous sulfate & 80 mg of mucin; used in treatment of iron-deficiency anemia
ferrous sulfide: rn given refers to cpd with mf of fe-s; mackinawite & troilite both have mf fe-s
ferroverdin: inhibits cholesteryl ester transfer protein; green iron-containing pigment produced by streptomyces
ferroverdin B: inhibits cholesteryl ester transfer protein; isolated from streptomyces
ferroverdin C: inhibits cholesteryl ester transfer protein; isolated from streptomyces
ferrugicadinol: from the bark of calocedrus macrolepis var. formosana
ferrugieudesmol: from the bark of calocedrus macrolepis var. formosana
ferruginene A: cytotoxic cpd from rhododendron ferrugineum
ferruginene B: cytotoxic cpd from rhododendron ferrugineum
ferruginene C: cytotoxic cpds from rhododendron ferrugineum
ferruginine: norferruginine is a nicotinic acetylcholine receptor agonist
ferruginine methiodide: agonist of nicotinic acetylcholine receptors
fertilization antigen: causes reduction of fertility in actively immunized rabbits; involved in involuntary immunofertility in humans; mw 47kda & 23kda, dimeric & monomeric forms, respectively
fertilogen: produced by "neofarm", republic of georgia, patent no. p4645p (latin letters) for the treatment of infertile couples with autoimmune diseases
ferulaldehyde: antimicrobial and antioxidant from root bark of cordia gilletii (boraginaceae)
ferulenol: intoxicating component of powdered ferula communis variety brevifolia; rn given for (e,e)-isomer
ferulic acid-4-O-sulfate: has antihypertensive and vasodilating activities
ferulin C: sesquiterpene coumarin, isolated from the roots of ferula ferulaeoides (steud.)
feruloyl arabinobiose: from cell walls of spinach cells & sugar beet pulp; rn refers to open chain compound
feruloyl esterase: splits ester bond of methyl 5-o-feruloylarabinofuranoside to release ferulic acid; catalyzes the hydrolysis of the 4-hydroxy-3-methoxycinnamoyl (feruloyl) group from an esterified sugar, which is usually arabinose in 'natural' substrates; see also record for feruloyl-4-coumaroyl esterase
feruloyl-4-coumaroyl esterase: from penicillium pinophilum; releases ferulic acid & para-coumaric acid from esterified wheat straw xylan; can also release acetic acid from p-nitrophenyl acetate & from an acetylated xylan; acts synergistically with celluclast
feruloyl-CoA - arabinoxylan-trisaccharide O-hydroxycinnamoyl transferase: catalyzes the transfer of ferulic acid from fer-coa to arabinoxylan-trisaccharide in the formation of feruloyl arabinoxylan-trisaccharide
feruloyl-coenzyme A reductase: converts feruloyl coa to coniferyl aldehyde
feruloyldopamine: a dopamine metabolite isolated from tomatoes after infection by pseudomonas syringae
feruloyltyramine: ; isolated from cannabis sativa seeds, roots, leaves, and resin; induces hypothermia and motor incoordination in mice; moupinamide is (e)-isomer
feslol: from oleo-gum resin of ferula assa-foetida l
fesselin: a synaptopodin-like protein that stimulates nucleation and polymerization of actin; amino acid
fetal Alzheimer antigen: fac1 - fetal alz-50-reactive clone 1; located both in nucleus and cytoplasm of cells of the developing cortex
fetal hemoglobin F(Ic): minor fetal hemoglobin; contains gamma chains mostly acetylated at the amino terminus
fetal steroid-binding protein, human: sex steroid-binding protein distinct from other estrogen- & androgen-binding protein sex hormone-binding globulin in normal serum; do not confuse with human fibrinogen silencer binding protein (aka fsbp)
fetal sulfoglycoprotein antigen, human: for cancer screening tests; normal structure in embryonal human alimentary canal; found regularly in gastric cancer cells & cancerous gastric juice; not found in gastric mucosa or gastric juice of young healthy subjects; occasionally found in non-malignant mucosal cells of gastric cancer patients; see also record for colonic-gastric mucus-associated antigens
fetidin: from the coelomic fluid of the annelid eisenia fetida andrei; amino acid sequence given in first source
fetoprotein transcription factor: mw 54-64 kda; activates the alpha1-fetoprotein (afp) gene; amino acid sequence given in first source
fevicordin-A: anticancer cpd from seeds of phaleria macrocarpa
fexapotide triflutate: caspase and tnf signaling pathway activator used to treat benign prostatic hyperplasia (bph)
fezakinumab: il-22 monoclonal antibody for the treatment of atopic dermatitis
fezolinetant: a neurokinin-3 receptor antagonist. a nonhormonal medication for treating menopausal hot flashes
fgf8a protein, zebrafish: genbank bc086718; refseq nm_131281
fgfbp1b protein, zebrafish: refseq xm_005170938
fhaC protein, Bordetella pertussis: from bordetella pertussis; a pore-forming outer membrane protein that interacts with fhab allowing for secretion of the fha adhesin
fhlA protein, E coli: mw 78.467 kda; transcriptional activator of the formate hydrogenlyase system of e coli; amino acid
fhuB protein, E coli: mediates ferric hydroxamate transport across inner membrane into cytoplasm of e coli; displays characteristics typical of a periplasmic-binding-dependent transport mechanism; amino acid sequence given in first source
fhuD protein, E coli: mediates ferric hydroxamate transport across inner membrane into the cytoplasm of e coli; displays characteristics typical of a periplasmic-binding-dependent transport mechanism; amino acid sequence given in first source
fhx protein, Bombyx mori: a component of silk fibroin, which consists of h-chain, l-chain, and p25; amino acid ; do not confuse with fhx protein
fib-1 protein, C elegans: genbank z78413; refseq nm_074290.4
fibA protein, bacteria: encodes an immunogenic subunit of the fibril-like surface structure of peptostreptococcus micros; has been sequenced
fiber protein NADC-1, Porcine adenovirus: amino acid ; genbank u25120; do not confuse with fiber protein from ovine adenovirus oav287; do not confuse with mammalian renal contransporter nadc-1
fiber-forming protein, Tetrahymena pyriformis: isolated from acetone powder of tetrahymena pyriformis; has mol wt 38 000 d & forms tetramer 140 000 d, 9s in physiological conditions
fibin protein, mouse: a secreted glycoprotein that is also found in the endoplasmic reticulum; refseq nm_026271
fibril protein, Spiroplasma citri: from spiroplasma citri; mw 59 kda; contains 515 amino acids; amino acid sequence given in first source
fibrillarin: a component of u3 small nucleolar ribonucleoprotein; found on putative chromosomal nucleolar organizer regions; common to the major family of nucleolar snrnps
fibrillin protein, Podocoryne carnea: homologous to mammalian fibrillins; composed of tandemly repeated epidermal growth factor-like repeats interrupted by a second cystein-rich motif; mw 330- to 340-kda; amino acid sequence has been determined
fibrin destabilase: hydrolyses the epsilon-(gamma-glutamyl)-lysine bonds of stabilized fibrin
fibrin self-assembly inhibitor: mw 1750 in humans & 1278 in rats
fibrinogen (gamma 95-264): generated by cyanogen bromide cleavage of human fibrinogen
fibrinogen Aalpha (1-50): corresponds to the sequence (1-50) of human fibrinogen alpha chain
fibrinogen Aalpha (148-160): specific amino acid sequence in this fibrinogen fragment needed for the enhancement of the rate of plasminogen activation by tpa
fibrinogen Ales: cause of dysfibrinogenemia; gamma(330)asp replaced by val
fibrinogen Almeria I: abnormal fibrinogen; has prolonged latency time & decrease in rate of gelation; has unpolymerized alpha chains
fibrinogen Asahi: thr replaced by met at position 310 of the gamma chain; mutation associated with post traumatic bleeding
fibrinogen Awaji: abnormal fibrinogen which causes hereditary disfibrinogenemia which impairs polymerization of fibrin monomer with various biological effects
fibrinogen Baltimore I: congenital abnormal fibrinogen; polymerization defect associated with a gamma(292)gly replaced by val(ggc--gtc) mutation
fibrinogen Baltimore II: fibrinogen found in patient with congenital hypodysfibrinogenemia; causes delayed release of fibrinopeptide b & decreased rate of fibrinogen synthesis
fibrinogen Baltimore III: abnormal fibrinogen; congenital dysfibrinogenemia with a shortened gamma-subunit
fibrinogen Banks peninsula: characterized by gamma280tyr--cys mutation; associated with mild bleeding
fibrinogen Barcelona I: congenital dysfibrinogenemia with defective release of fibrinopeptide a & fibrinogen degradation products
fibrinogen Barcelona II: congenital dysfibrinogenemia; aalpha 16 arg is replaced by his
fibrinogen Bbeta (1-42): rapidly cleaved from bbeta chain of fibrinogen or from fibrin-containing fpb(fibrin i) by plasmin when the fibrinolytic system is activated; mediates vascular endothelial cell retraction in vitro; mw less than 10,000
fibrinogen Bbeta (30-43): corresponds to amino acid residues 30-43 of the human fibrinogen bbeta-chain
fibrinogen Beograd: mutation (p.gly366ser), associated with hepatic fibrinogen storage disease
fibrinogen Bern I: asparagine replaced lysine at position 337 on the gamma chain
fibrinogen Bern II: hereditary fibrinogen variant with impaired release of fibrinopeptide a & markedly prolonged coagulation time; arginine replaced by histidine in position 16 of alpha chain
fibrinogen Bicetre II: asparagine replaced by lysine at position 308 of gamma chain
fibrinogen Bondy: abnormal fibrinogen with incomplete release of fibrinopeptides a & b
fibrinogen Bremen: glycine replaced by valine at position 17 of the aalpha chain
fibrinogen Caracas I: has an aalpha-chain truncation at aalpha-466 ser
fibrinogen Caracas II: a dysfibrinogen characterized by impaired fibrin gel formation; aalpha ser-434 replaced by n-glycosylated asn
fibrinogen Caracas V: cysteine replaces serine at position 532 of the aalpha subunit
fibrinogen Caracas VI: has mutation (deletion of aalpha-asn 80)
fibrinogen Caracas VIII: asparagine replaces tyrosine at position 41 of the bbeta chain
fibrinogen Chapel Hill II: hereditary, abnormal fibrinogen characterized by poor substrate reactivity toward thrombin, factor xiiia & plasmin
fibrinogen Claro: arginine replaced by histidine at position 275 of gamma chain
fibrinogen Copenhagen II: abnormal fibrinogen with increased sialic acid content associated with thrombotic tendency & normal liver function
fibrinogen Darlinghurst: from hypofibrinogenaemia patient with bleeding and thrombotic complications, caused by a w253g mutation in the gamma chain
fibrinogen Dusard: abnormal fibrinogen characterized by abnormal fibrin monomer polymerization & a decrease by 50% of the binding of lysyl-plasminogen to fibrin clots
fibrinogen Erfurt I: abnormal fibrinogen; characterized by abnormal bbeta-chain; present in both plasma and platelets
fibrinogen Frankfurt III, human: cysteine replaces arginine at position 16 of aalpha
fibrinogen Freiburg II: asparagine replaces serine at position of the gamma chain
fibrinogen Fremantle: arginine replaces tryptophan on position 335 of the gamma chain
fibrinogen Fukushima: identified in a patient with dysfibrinogenemia with mutation of gammar275c
fibrinogen Geneva: abnormal fibrinogen; aalpha 16 arg replaced by cys
fibrinogen Genova II: abnormal fibrinogen; causes congenital dysfibrinogenemia with isolated defect of fibrin monomer polymerization & inhibitory activity on normal coagulation
fibrinogen Giessen I: causes dysfibrinogenemia; homozygous for aalpha 16-arg-his; abnormal fibrinogen
fibrinogen Grand Rapids: causes congenital disfibrinogenemia; value of k(cat)/k(m) for release of fibrinopeptide a was 77 fold lower than for normal fibrinogen; exhibits reduced clottability
fibrinogen Grenoble: fibrinogen with abnormal rate of fibrin monomer aggregation; has both normal & abnormal gamma chains of greater molecular mass
fibrinogen Guarenas: stop codon (taa) replaces glutamate at position 467 of aalpha chain
fibrinogen Hershey IV: isoleucine replaces valine at position 411
fibrinogen IJmuiden: cys replaces arg at position 14 of bbeta polypeptide
fibrinogen Irvine: slow clotting dysfibrinogen; impaired fibrinopeptide a release
fibrinogen Ise: congenital abnormal fibrinogen characterized by bbeta gly-15 replaced by cys
fibrinogen Kanazawa: a congenital dysfibrinogenaemia with delayed polymerization having a replacement of proline-18 by leu in the aalpha chain
fibrinogen Kawaguchi: abnormal fibrinogen characterized by defective release of fibrinopeptide a
fibrinogen Kiel: a congenital fibrinogen variant with substitution of his in position 16 of the aalfa-chain for arg
fibrinogen Kyoto I: gamma-asp replaced by lys at position 308; this causes accelerated cleavage of fragment d1 by plasmin and the generation of a new plasmin cleavage site
fibrinogen Kyoto II: causes disfibrinogenemia; characterized by the replacement of aalpha proline-18 by leucine
fibrinogen Kyoto III: gamma-asp replaced by tyr at position 330; congenital dysfibrinogen; manifests impaired fibrin monomer polymerization
fibrinogen Lima: has a high molecular weight alpha-chain; arg replaced by ser at aalpha141
fibrinogen Longmont: cysteine replaces arginine at position 166 of the bbeta chain
fibrinogen Madrid I: congenital dysfibrinogenemia with abnormal fibrinopeptide b release
fibrinogen Madrid II: congenital dysfibrinogenemia with abnormal fibrinopeptide b release; case seems similar to madrid i, but they are from different families with some diferent activities
fibrinogen Magdeburg: abnormal fibrinogen; inherited dysfibrinogenaemia without any clinical illness
fibrinogen Malmoe: abnormal fibrinogen; cause of congenital hypodysfibrinogenaemia
fibrinogen Mannheim V: heterodimeric fibrinogen partially conjugated with albumin in a dysfibrinogen
fibrinogen Marburg: abnormal fibrinogen with a single base substitution of alanine by threonine which changes the codon a alpha 461 aaa (lys) to taa (stop)
fibrinogen Matsumoto I: a dysfibrinogen where asp was replaced by his at position a gamma 364 (gat replaced by cat); associated with defective fibrin polymerization
fibrinogen Matsumoto II: a variant with (gamma308asn-->lys) mutation
fibrinogen Matsumoto V: a variant with aalpha19 arg-->gly (agg-->ggg) mutation
fibrinogen Matsumoto VII: has a frameshift mutation at codo 387 of gamma-chain
fibrinogen Merivale: mutation bbeta255 arg--->his with hypofibrinogenemia
fibrinogen Metz: homozygous disfribinogenemic mutant; arginine replaced by cysteine in position aa16
fibrinogen Milano I: aspartic acid replaced by valine at position gamma 330; fibrin polymerization impaired
fibrinogen Milano II: defective interaction with thrombin is associated with a defective binding of thrombin to the fibrin moiety of milano ii
fibrinogen Milano III: a homozygous fibrinogen variant with truncated aalpha chains
fibrinogen Milano IV: arginine replaced by histidine at position 16 of the alpha chain of fibrinopeptide a
fibrinogen Milano VI: heterozygous dysfibrinogenemia with bleeding tendency; aalpha 16 arg replaced by his
fibrinogen New Orleans: inherited abnormal fibrinogen which causes delayed cleavage of fibrinopeptide a
fibrinogen New York 1: abnormal fibrinogen from family with thrombotic tendency; deletion of sequence bbeta (9-72)
fibrinogen Nieuwegein: has a homozygous insertion of a single nucleotide (c) in codon aalpha 453 (pro) which introduced a stop codon at position 454 resulting in the deletion of the carboxyl-terminal segment aalpha 454-610
fibrinogen Nijmegen: congenital dysfibrinogenemia associated with impaired t-pa mediated plasminogen activation & decreased binding of t-pa; cys replaces arg at position 44 of bbeta polypeptide chain
fibrinogen Novy Jicin: cysteine replaces arginine at position 16 of the aalpha chain
fibrinogen Osaka II: arg replaced by cys at position 275 of the gamma chain
fibrinogen Osaka VI: has a 12-residue carboxyl-terminal extension of lys-ser-pro-met-arg-arg-phe-leu-leu-phe-cys-met due to a t-to-a mutation that creates aag encoding lys at the stop (tag) codon, thus translating 36 base pairs in the noncoding region of the bbeta gene; associated with severe bleeding;
fibrinogen Oslo IV: abnormal fibrinogen with polymerization defect in familial dysfibrinogenemia
fibrinogen Otsu I, human: possesses an gammaasn319,asp320 deletion
fibrinogen Oviedo I: this cpd has inhibitory effect on the thrombin time of normal plasma; this defect may be due to conformational modifications in the d section of the molecule
fibrinogen Perth: has aalpha chain truncation resulting in low expression and impaired fibrinogen polymerization
fibrinogen Petoskey: abnormal fibrinogen in which arg-a alpha 16 is relaced by a histidyl residue causing dysfibrinogenemia
fibrinogen Pisa: mutation (p.asp316asn), associated with hepatic fibrinogen storage disease
fibrinogen Poissy II: lysine replaces asparagine at position 361 of gamma chain
fibrinogen Praha II: histidine replaces arginine at position 16 of the aalpha chain
fibrinogen Rokycany: has heterozygous point mutation bbeta asn351lys
fibrinogen Saint-Germain I: associated with dysfibrinogenemia; has heterozygous aalphagly12val mutation
fibrinogen San Giovanni Rotondo: alanine replaced with alanine frameshift stop at position 499 of alpha chain
fibrinogen Seattle: clinically silent, slow-clotting dysfibrinogen, releases 50% of normal amount of fibrinopeptide b
fibrinogen Seattle II: exhibits delayed release of fibrinopeptide a, delayed onset of clotting & decreased rate of clot formation
fibrinogen Sevilla: congenital dysfibrinogenemia characterized by an abnormal monomer aggregation & a defective plasmin lysis
fibrinogen Stony Brook II: causes prolonged clotting time & delayed onset of clot turbidity; possible aalpha16 arg substituted by his
fibrinogen Sydney I: fibrinogen from case of disfibrinogenemia; aalpha arginine(16) replaced by histidine
fibrinogen Tahiti: associated with dysfibrinogenemia; has heterozygous aalpha arg16his mutation
fibrinogen Tokyo II: abnormal fibrinogen with mutation in the d domain of the fibrin polymerization site
fibrinogen Tolaga Bay: a gammaala341val mutation causing hypofibrinogenaemia
fibrinogen Tottori II: congenital hypofibrinogenemia is caused by a nonsense mutation in the fibrinogen bbeta chain gene mutation (tat sequence for bbeta 41tyr to tag sequence for a translation termination signal)
fibrinogen Vicenza: abnormal fibrinogen; causes congenital disfibrinogenemia with isolated defect of fibrin monomer polymerization & inhibitory activity on normal coagulation
fibrinogen Vlissingen: congenitally abnormal fibrinogen with a 6-base deletion in the gamma-chain gene, causing defective calcium binding & impaired fibrin polymerization
fibrinogen Wilmington: dysfibrinogenemia (fibrinogen wilmington) due to aalpha chain truncation causes decreased plasma expression and impaired fibrin polymerisation
fibrinogen Zabrze: histidine replaces arginine at position 275 of gamma-chain
fibrinogen Zlin: isoleucine replaces threonine at position 21 of the gamma chain
fibrinogen alphaC: plays a role in maintaining hemostasis by serving as a substrate for factor xiiia and plasmin
fibrinogen clotting enzyme, Lachesis muta muta: thrombin-like enzyme from pyruvian bushmaster venom, releases fibrinopeptide a rapidly from purified alpha-n-benzoyl-dl-arginine-p-nitroanilide, alpha-n-benzoyl-l-arginine ethyl ester & tosyl-l-arginine methyl ester
fibrinogen fragment (Hol-DSK): contains all three chains of fibrinogen molecule; mw appr. 43,000; has effect on immune system
fibrinogen fragment X: large fragments (mw 240,000 to 265,000) formed early in the course of fibrinogen digestion by plasma
fibrinogen gamma (151-411): a c-terminal domain peptide fragment that functions as both an angiogenesis inhibitor and antineoplastic agent
fibrinogen gamma 399 truncated: a c-terminal domain peptide fragment that functions as both an angiogenesis inhibitor and antineoplastic agent
fibrinogen peptide 6A: found in lysate from fibrinogen degraded by plasma
fibrinogen peptide 6D: found in lysate from fibrinogen degraded by plasma
fibrinogen-binding protein A, Staphylococcus aureus: a fibrinogen-binding protein from staphylococcus aureus; genbank u20794
fibrinogen-binding protein, Streptococcus equi: part of fibrinogen-binding protein complex that protects mice against lethal challenge with streptococcus equi; genbank af012927
fibrinogen-related protein 3, Biomphalaria glabrata: parasite-responsive igsf (immunoglobulin super family) members in the snail biomphalaria glabrata; gene has tandemly arranged igsf domains and a fibrinogen domain; genbank ay028461
fibrinogen-related protein 7, Biomphalaria glabrata: parasite-responsive igsf (immunoglobulin super family) members in the snail biomphalaria glabrata; gene has tandemly arranged igsf domains and a fibrinogen domain; genbank ay028462
fibrinogenase, Bitis arietans: a 100 kda fibrinogenase from the venom of bitis arietans; amino terminal amino acid
fibrinolytic agent LTI-01: a new form of single-chain urokinase plasminogen activator produced in cho cells
fibritin protein, Enterobacteria phage T4: 486 amino acid residues
fibroblast activation protein alpha: expressed by stromal fibroblasts of epithelial cancers; a large, gelatin-degrading membrane protease complex, may be a marker for melanoma cell invasiveness; genbank u09278
fibroblast chemotactic inhibitor: mw 230,000; normal human serum protein which inhibits fibroblast chemotactic & random migration
fibroblast growth factor (1-10): tyr(10) labeled with 125i
fibroblast growth factor 13: expressed in heart, connective tissue, and nervous tissue; isolated from mouse; amino acid ; refseq nm_004114 (human)
fibroblast growth factor 14: amino acid ; genbank ab008907 and ab008908
fibroblast growth factor 18: sprifermin is a recombinant human fgf-18; amino acid ; genbank ab004638, ab004639, and ab007742
fibroblast growth factor 20, Xenopus: isolated from xenopus laevis and later from human; amino acid ; genbank ab012615 (xenopus)
fibroblast growth factor 20, zebrafish: fgf20a represents a null mutation which has no impact on embryonic survival; amino acid
fibroblast growth factor 21: hormone effects involved with hibernation, starvation and metabolism, causing a metabolic shift to burning stored fats instead of carbohydrates
fibroblast growth factor 25, zebrafish: 186 amino acid residues; amino acid sequence known
fibroblast growth factor receptor, Halocynthia roretzi: involved in the differentiation of notochord cells and mesenchyme cells of the ascidian halocynthia roretzi; amino acid
fibroblast growth factor-1 (112-147): mitogenic for cultured fibroblasts; aa seq given in first source
fibroblast growth factor-1, S130K substituted: mutant form of fibroblast growth factor-1 (fgf-1), with lysine replacing serine in the heparin-binding site at amino acid 130
fibroblast motility-stimulating factor: a paracrine motility factor from human soft tissue sarcoma cells; identified as the n-terminal fragment of fibronectin
fibroblast pneumonocyte factor: low-molecular wt polypeptide produced by fetal lung in response to glucocorticoids; exogenous cpd has been shown to accelerate lung maturation
fibroblast stimulating factor-1: a heparin-binding growth factor produced by egg granulomas; partial amino acid sequence has been determined
fibroblast-derived tumor cytotoxic factor: isolated from human embryonic lung fibroblasts; cytotoxic against various human & mouse tumor cells; very similar and may be identical to the hepatocyte growth factor; has 2 chains, alpha & beta, mw 76-80 kda; has been sequenced
fibroin, silkworm: a protein consists of a heavy chain and a light chain linked by a disulfide bond. polymers of silk fibroin constitute fibroin filaments. a raw silk strand (300-600 meters) consists of two fibroin filaments coated by a sticky gum protein, sericin
fibrolase: from the venom of agkistrodon contortrix; direct-acting fibrin-degrading zinc-metalloproteinase; mw 23-25kda; cleaves primarily the aa-chain of human fibrinogen & fibrin between the lys-413 & leu-414 position; the bb chain is cleaved more slowly; gamma chain is minimally affected
fibronectin attachment peptide: binds to adhesion receptors & competitively inhibits the binding of collagen on the proliferation of e1 cells
fibronectin hexapeptide N-acetylgalactosaminyltransferase: enzyme from fetal & malignant tissues recognizing the sequence val-thr-his-pro-gly-tyr in fibronectin
fibronectin laminase: fibronectin fragment which has been activated by calcium chloride to produce a calcium-dependent proteolytic activity that splits preferentially laminin & denatured collagen type 1; cleaves the ala-gly bond in the sequence gpagpr; the arginine residue in position p3' is important for this cleavage
fibronectin type III like peptide, human: a peptide of around 7.4 kda has been purified from the aqueous extract of human placenta used as wound healer
fibronectin-TF3-218: hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen; fibronectin structural motif of tandem repeating modules with four type iii repeat modules of fibronectin followed by two structurally homologous modules of the extracellular domain of tissue factor; this hybrid protein of six tandem modules recognizes integrins and selectively docks and initiates the thrombogenic protease cascade locally on the target cell surfaces; has been sequenced
fibronectin-attachment protein, Mycobacterium leprae: involved in efficient invasion of epithelial and schwann cells; amino acid sequence has been determined
fibronectinase: generated from a 27kda n-terminal heparin-binding fragment of fibronectin; calcium-dependent
fibropellin protein, sea urchin: member of the epidermal growth family in the sea urchin strongylocentrotus purpuratus; amino acid sequence given in first source
fibrosin: a fibrogenic lymphokine; has potent fibroblast mitogenic activity; amino acid sequence given in first source; genbank u20239
fibrosterol sulfate A: isolated from the sponge lissodendoryx (acanthodoryx) fibrosa
fibrosurfin: contains a sea urchin fibrilar (surf) domain; a component of sea urchin catch connective tissues; genbank aj291489
fibrous sheath protein 75: a major fibrous sheath protein of mw 75 kda from sperm; amino acid
fibrous sheath protein 95: a testis-specific 95-kilodalton fibrous sheath antigen; amino acid
fibstatin protein, human: an endogenous extracellular m(r) 29,000 fgf-2-binding basement membrane-derived inhibitor of angiogenesis and tumor growth; amino acid
fibulin: interacts with the fibronectin receptor beta subunit cytoplasmic domain; potential mediator of interactions between adhesion receptors & the cytoskeleton; refseq nm_006485 (human); nm_010180 (mouse);
fibulin 2: an extracellular matrix protein with multiple egf-like repeats; amino acid sequence given in first source; genbank x75285
ficaprenyl alpha-D-mannopyranosyl phosphate: active intermediate of mannan biosynthesis in micrococcus lysodeikticus
ficaprenyl galactosyl diphosphate: rn given refers to (d)-isomer
ficulinic acid A: cytotoxic straight chain acid from sponge ficulina ficus; structure & mf c26-h48-o3 given in first source
ficulinic acid B: cytotoxic straight chain keto acid from sponge ficulina ficus
ficuseptine B: phenanthroindolizidine alkaloid from stem of ficus septica
ficuseptine C: phenanthroindolizidine alkaloid from stem of ficus septica
ficuseptine D: phenanthroindolizidine alkaloid from stem of ficus septica
ficusoside B: from the wood of ficus elastica roxb. ex hornem. aerial roots
fiduxosin: fiduxosin (abt-980) is the (3ar,9br)-isomer
figitumumab: an anti-insulin-like growth factor-i receptor monoclonal antibody in phase i clinical trials
fijiolide A: inhibitor of tnf-alpha-induced nfkappab activation, from a marine-derived sediment bacterium of the genus nocardiopsis
fijiolide B: inhibitor of tnf-alpha-induced nfkappab activation, from a marine-derived sediment bacterium of the genus nocardiopsis
filament-associated late protein, entomopoxvirus: a 25-27 kda protein expressed in insect cells infected with amsacta moorei entomopoxvirus (amepv); amino acid sequence given in first source
filamentous hemagglutinin adhesin, Bordetella pertussis: 220 kda polypeptide from b. pertussis; amino acid sequence characterized from fhab structural gene (10774 nucleotides); a rod-shaped protein expressed by bordetellae that is both surface-associated and secreted; fha protein is processed from the precursor protein fhab
filarin protein, Haemopis marmorata: an invertebrate protein present in axons & perikarya of developing & mature leech neurons; mw 63 kda; genbank u22459
filensin: a 100-110 kd membrane-associated protein found in lens fiber cells; has been sequenced
filia protein, mouse: part of a subcortical maternal complex involved in zygote progression to further cell divisions; genbank ak010377
filicene: antinociceptive from adiantum cuneatum (adiantaceae) leaves
filicin: active principle of the male fern (dryopteris filixmas (l.) schott.)
filicinoside A: a furostanoside; isolated from the roots of asparagus filicinus
filicinoside B: a furostanoside; isolated from the roots of asparagus filicinus
filiferol: from washingtonia filifera possibly involved in the defence against the red palm weevil rhynchophorus ferrugineus olivier