NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
thrombosthenin: contractile protein localized in blood platelets; it is the major factor in clot retraction & the spontaneous shrinkage of in vitro formed platelet aggregates; minor descriptor (75-85); on-line & index medicus search blood proteins (75-85)
thromboxane dehydrogenase: converts thromboxane b2 to 11-dehydro-thromboxane b2, but not the reverse reaction; uses nad but not nadp as cofactor; only attacks the 11-hydroxy group of txb2
thulium(III) 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetramethylenephosphonate: paramagnetic chemical shipt reagent
thylacine 1 protein, Xenopus: involved in notch pathway; isolated from xenopus; amino acid ; genbank y14446
thylacine 2 protein, Xenopus: isolated from xenopus; amino acid ; genbank y14447
thylakoid membrane phosphoprotein, plant: mw 9000; from spinach chloroplast thylakoid membrane; see also related records for thylakoid polypeptides & thylakoid intrinsic protein
thylakoid polypeptides: see also specific thylakoid intrinsic protein & thylakoid membrane phosphoprotein
thylakoid processing peptidase: signal type peptidase with stringent substrate requirements at the -3 and -1 positions; removes amino-terminal peptide extension which transports proteins across the thylakoid membrane
thymarin: polypeptide; rn given refers to cpd with unknown mf; may be same as thymalin; see also thymalin
thyme extract and ivy extract drug combination: containing extracts of thymus vulgaris and primula veris; major components are thymol and 1,8-cineol
thymeleatoxin: causes translocation & down-regulation of multiple protein kinase c isozymes
thymic humoral factor gamma 2: synthetic octapeptide thymic hormone which repairs immunodeficiency of mice cured of plasmacytoma by melphalan
thymic shared antigen-1: tsa-1 is identical to sca-2; a mouse thymocyte marker; a phosphatidylinositol-linked surface protein, member of the ly6 family; amino acid sequence given in first & second source; genbank u04268
thymic shared antigen-2: a 28 kda cell surface marker associated with t cell differentiation & activation; expressed on thymic stroma & developing cells
thymidine 5'-(alpha,beta-imido)triphosphate: ; inhibits hiv-1 reverse transcriptase
thymidine 5'-diphosphate: see also record for thymidine 3',5'-diphosphate, rn 2863-04-9
thymidine 5'-phosphonate: inhibitor of amp hydrolsis in primary myocytes
thymidine diphosphate glucose 3-aminotransferase, Streptomyces achromogenes: catalyzes the conversion of tdp-3,4-diketo-2,6-dideoxyglucose to tdp-3-amino-4-keto-2,6-dideoxyglucose
thymidine diphosphate glucose 4-ketoreductase, Streptomyces achromogenes: catalyzes the conversion of tdp-3,4-diketo-2,6-dideoxyglucose to tdp-3-keto-2,6-dideoxyglucose
thymidine diphosphate sugars: esters formed between the aldehydic carbon of sugars & terminal phosphate of thymidine diphosphate; minor descriptor (75-85); on-line & index medicus search nucleoside diphosphate sugars (75-85)
thymidine diphosphate-4-keto-6-deoxy-D-glucose reductase: converts dtdp-4-keto-6-deoxy-d-glucose to dtdp-d-fucose with oxidation of nadph to nadp
thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase: catalyzes conversion of dtdp-6-deoxy-l-lyxo-4-hexulose to dtdp-6-deoxy-talose; amino acid
thymidine glycol 5'-triphosphate: rn & ; rn not in chemline 5/87; substrate for e coli polymerase i
thymidine kinase 1: tk1 is member of a large conserved gene cluster in mammals
thymidine kinase 2: human enzyme phosphorylates thymidine, deoxycytidine, deoxyuridine and anti-viral and anti-cancer nuucleoside analogs; amino acid
thymidine kinase, Canid herpesvirus 1: amino acid ; genbank x75765
thymidine-5'-tri-3'-diphosphate: synthesized by enzymatic transfer of 5'-beta,gamma-pyrophosphoryl group from datp
thymidine-diphospho-4-keto-6-deoxyglucose epimerase: catalyzes the formation of tdp-4-keto-l-rhamnose from thymidine-diphospho-4-keto-6-deoxy-d-glucose
thymidyl 3'-(4-nitrophenyl)phosphorothioate: ; rn given is for (r)-isomer
thymidylate synthase-dihydrofolate reductase: bifunctional multienzyme complex purified from leishmania major
thymidylyl-(3'-5')-2'-deoxy-5-fluorouridine: forms photoproducts
thymidylyl-(3'-5')deoxyuridine: forms photoproducts
thymidylyl-(5'-3')-thymidylate (5')-hydrate: rn given refers to di-salt
thymine, 2-oxoglutarate dioxygenase: 5-hydroxymethyluracil,2-oxoglutarate dioxygenase was formerly ec 1.14.11.5; for this activity, substrate thymine may be replaced by uracil/analogs
thyminenol: from the marine sponge haliclona sp.; stucture in first source
thymocyte growth peptide: apparent mw 1600; n-terminal blocked hydrophilic peptide; no apparent relationship to previously defined growth factors or thymic differentiation hormones
thymocyte interaction modulation factor: soluble glycoprotein relesed by thymocytes which reduced mutual adhesion between b-lymphocytes
thymocyte selection-associated high-mobility group box protein, mouse: refseq nm_145711
thymocyte-activating factor, fibroblasts: mw 25,000, 35,000, 45,000; cytokine from human gingival fibroblasts; has autoregulatory effect on their proliferation
thymocyte-expressed molecule involved in selection, human: refseq nm_001010923
thymodepressin: a synthetic peptide, promoted take of transplanted hemopoietic precursor cells in the bone marrow of irradiated mice
thymogen: synthetic peptide; a nasal solution used in the treatment of aids-related kaposi sarcoma
thymohemin: consists of thymus & bone marrow polypeptides (thymalin and hemalin)
thymohexin: used in the immunorehabilitation of patients with chronic brucellosis; synthetic hexapeptide; may be related to thymopentin
thymol-beta-D-glucopyranoside: glucose conjugate of thymol
thymolymphotropin: exerts recovery effects on the functionality of some membrane-bound mitochondrial & lysosomal enzymes affected by gamma-irradiation; also exerts antistress effects
thymone C: peptide isolated from bovine thymus which stimulated mixed lymphocyte reaction
thymopoietin II octadecapeptide (32-49): amino acid sequence given in first source
thymopoietin III: 48 aa monomeric peptide isolated from bovine spleen; thymopoietins i & ii are from thymus
thymopoietin pentapeptide-fluorescein isothiocyanate: fluorescent probe for thymopentin
thymopoietin pentapeptide-stilbene isothiocyanate: fluorescent probe for thymopoietins
thymopoietin, Cys (28-39)-: synthetic thymopoietin used for immunohistochemical localization of thymopoietin
thymosin beta(1): amino acid sequence given in first source; ubiquitin t was an en to ubiquitin 1985-93
thymosin beta(10): found in mammalian spleen, liver & thymus; composed of 42 amino acid residues; shows 75% sequence homology with thymosin beta(4)
thymosin beta(10)arginine: from rabbit tissue, variant of thymosin beta(10) in which arg is inserted following lys-38
thymosin beta(11): peptide containing 41 amino acid residues; isolated from trout liver
thymosin beta(12): amino acid sequence given in first source; isolated from trout (salmo gairdneri) spleen
thymosin beta(14): 40 amino acid residues, mw 4537 da; 73% homologous to beta(4); amino acid sequence given in first source
thymosin beta(4): biological active peptide present in thymosin fractions 5 & 5a; participates in the regulation, differentiation & function of thymus-derived lymphocytes & may also act directly or indirectly on macrophages & other cells involved in cell-mediated immunity
thymosin beta(4) sulfoxide: thymosin beta(4) oxidized at met(6)
thymosin beta(4)alanine: from rabbit tissue; contains ala in place of ser at the blocked nh2 terminus
thymosin beta(9): amino acid sequence given in first source; rn given refers to all (l)-isomer
thymosin beta(9), methionine: identical to thymosin beta(9); except that methionine is substituted for leucine in position 6
thymosin beta-NB, human: thymosin beta-nb is the human isoform of rat thymosin beta15; genbank d82345; protein baa11556
thymosin beta15, rat: thymosin beta-nb is the human isoform of rat thymosin beta15; genbank u25684; protein aab37101
thymosterin B: thymus extract of a lipid nature which stimulates serum antibodies
thymosterol A: isolated from thymosin; rn given refers to thymosterol a with unknown mf
thymostimulin: partially purified thymic extract of calf thymus; increases the percentage of thy-1-positive cells of mouse spleen & their responsiveness to phytohemagglutinin & con a stimulation; complex of thermostable nondialyzable polypeptides
thymus-leukemia antigens: membrane-associated glycoproteins of murine leukemia cells; human thymus leukemia-associated antigen has been recently identified as a thymic isoenzyme of adenosine deaminase 5/28/81
thyroactive iodinated casein: consumption is associated with reversible hyperthyroidism and cardiomyopathy; protamone is a trade name
thyroglobulin peptide (2495-2511): a synthetic peptide corresponding to amino acids 2495-2511 of the human thyroglobulin sequence
thyroglobulin peptide (2651-2670): a highly immunogenic human thyroglobulin 20mer peptide
thyroglobulin peptide (2695-2706): can induce autoimmune thyroiditis in mice; amino acid
thyroglobulin peptide (2695-2713): corresponds to human thyroglobulin amino acids 2695-2713; sequence of the last 348 aa of human tg (2401-2748) given in first source
thyroid hormone receptor alpha B, flounder: high affinity receptor for triiodothyronine; belongs to the nuclear hormone receptor family, the nr1 subfamily; isolated from flounder; genbank d16462
thyroid hormone receptor alpha, human: refseq nm_001190918 (isoform 3)
thyroid stimulation-blocking antibody: blocking-type antibody to thyrotropin receptor in graves'disease in late pregnancy
thyroidin: dried extract of thyroid diluted with milk sugar or other suitable diluent, equal in potency to official thyroid
thyroliberin pyroglutamylpeptidase: aspect of ec 3.4.19.3 (formerly ec 3.4.11.8)
thyrostimulin: a heterodimer of two new human glycoprotein hormone subunits (alpha2 (a2) and beta5 (b5)) that activates the thyroid-stimulating hormone receptor; human thyrotropin (tsh), luteotropin (lh), follitropin (fsh), and chorionic gonadotropin are members of the heterodimeric glycoprotein hormone family, the common alpha subunit forms noncovalent heterodimers with different beta subunits; genbank af403384 (a2), af403430 (b5)
thyrotropin receptor (256-275): the peptide sequence 256-275 is part of a high affinity tsh binding site; important in hormone binding
thyrotropin releasing hormone, CRM45: an immunotoxin containing a modified thyrotropin-releasing hormone (trh) molecule coupled to a diphtheria toxin-related polypeptide
thyrotropin-releasing hormone-associated peptide 3, human: derived from preprotrh
thyroxine, triiodothyronine drug combination: combination of sodium levothyroxine and sodium l-triiodothyronine in a ratio of 4 to 1 by weight; rn given refers to parent cpd
thyroxine-UDP-glucuronosyltransferase: involved in hepatic biotransformation of thyroid hormones and may play a role in thyroid tumor promotion
thyroxine-binding globulin Chicago: variant thyroxin-binding globulin with marked resistance to heat denaturation
thyroxine-binding globulin-Buffalo: complete deficiency of thyroxine-binding globulin (tbg); amino acid
thyroxine-binding globulin-Gary: ile 96 is replaced by asn
thyroxine-binding globulin-San Diego: ser-23 replaced by thr
thyrsiferol: rn given for (2r-(2alpha(s*(s*(2r*,5r*))),4abeta,(alpha(2s*,5r*),8aalpha)-isomer; a marine algae metabolite
thyrsiferyl 23-acetate: inhibits phosphoprotein phosphatase 2a; isolated from marine red alga
tiadilon: negwer refers to cpd as arginine salt of tidiacicate; ud refers to it as drug combination containing tidiacicate & arginine; used negwer's definition for indexing
tian-xian: a phytogenic antineoplastic agent consisting of radix ginseng, cordyceps, radix astragali, radix glycyrrhizae, rhizoma dioscorea, margarita, fructus lycii, ganoderma, fructus ligustri lucidi, and herba scutellariae barbatae
tiancimycin A: 10-membered anthraquinone-fused enediyne from streptomyces sp. cb03234
tianfoshen: for treatment of colorectal cancer, composed of radix panacis quinquefolii, venenum bufonis, radix asparagi, bulbus iphigenia indica, radix acanthopanax obouatus, radix actinidia chinensis planch, fructus hippophae, and fructus citri sarcodactylis
tianhuang: lowers intracranial pressure and downregulates mmp-9 expression; consists of radix notoginseng, radix et rhizoma rhei, and borneolum syntheticum
tianma gouteng: gastrodiae rhizoma, uncariae ramulus cum uncis, cassiae semen, polygoni multiflori radix, plantaginis semen, achyranthis bidentatae radix, alismatis rhizoma, salviae miltiorrhizae radix, prunellae spica, persicae semen, raphani semen, pheretima, and carthami flos
tianma gouteng yin: has antihypertensive activity; consists of tianma (rhizoma gastrodiae), gouteng (ramulus uncariae cum unicis), shijueming (concha haliotidis), zhizi (fructus gardeniae), huanqin (radix scutellariae), chuanniuxi (radix cyathulae), duzhong (cortex eucommiae), yimucao (herba leonuri), sangjisheng (herba taxilli), yejiaoteng (cauls polugoni multiflori), and fushen (poria)
tianmushanol: complex sesquiterpenoid with tyrosinase inhibitory activity from the leaves of chloranthus tianmushanensis
tiao geng decoction: contains rehmannia glutinosa libosch, paeonia lactiflora pall, morinda officinalis how, epimedium brevicornum maxim, anemarrhena asphodeloides bge, phellodendron chinense schneid, longgu, ostrea gigas thunberg, polygonum multiflorum thunb
tiao jing cu yun: used to restore menstrual flow and stimulate the ovaries; consists of astragalus, dodder, pilose antler, medlar, broiled epimedium, himalayan teasel root, parasitic loranthus, and chinese yam
tiaomian III: has immunomodulatory activity; used to prevent spontaneous abortion; consists of human placenta, epimedium, morinda officinalis, astragalus, codonopsis pilosula, cuscuta chinensis, dipsacaceae, eucommia cortex, white peony root, roasted rhizoma atractylodis macrocephalae, glycyrrhiza uralensis, and other herbs
tiaramide: nta-194, solantal, fk 1160 refer to mono-hcl salt; rn given refers to parent cpd
tiarellic acid: new 27-carboxylic lupane-type triterpene from tiarella polyphylla (saxifragaceae)
tibric acid: was mh 1979-91 (see under piperidines 1979-90)
tichocarpol A: phenylpropanoid with feeding-deterrent activity from the red alga tichocarpus crinitus
tichocarpol B: phenylpropanoid with feeding-deterrent activity from the red alga tichocarpus crinitus
tick anticoagulant peptide: amino acid sequence given in first source; inhibitor of blood coagulation factor xa
tieghemelin: from tieghemella heckelii (sapotaceae)
tiegusanin G: has anti-hiv activity from schisandra propinqua var. sinensis
tien-hsien liquid: has immunomodulating effect on peripheral blood mononuclear cells and t-lymphocytes from patients with recurrent aphthous ulcerations
tiformin: has hypoglycemic activity & lowers blood urea levels in diabetics; rn in chemline for hcl: 23256-39-5
tigA protein, Phytophthora infestans: a transcriptional fusion of glycolytic genes encoding triose-phosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase in oomycota; also found in other members of oomycota; do not confuse with tiga protein from aspergillus nidulans which is a protein-disulfide isomerase; amino acid ; genbank x64537
tigapotide: a synthetic peptide corresponding to amino acids 31-45 of psp94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion
tigatuzumab: an agonistic humanized monoclonal antibody targeting death receptor 5
tigencaoside A: from the rhizomes of helleborus thibetanus franch
tigencaoside B: from the rhizomes of helleborus thibetanus franch
tiger ointment: ointment containing clove & eucalyptus oils, camphor, menthol, vaseline & paraffin
tigerinin-1M peptide, Xenopus muelleri: stimulates interleukin-10 production but suppresses interferon-gamma production
tigerinin-1R peptide, Hoplobatrachus rugulosus: stimulates interleukin-10 production
tigerinin-1V peptide, Lithobates vaillanti: stimulates interleukin-10 production but suppresses interferon-gamma production
tigloyl-CoA-13-hydroxymultiflorine-13-hydroxyupanine O-tigloyltransferase: catalyzes the tigloyl transfer from tigloyl-coa to 13-hydroxymultiflorine and 13-hydroxyupanine
tigloylshikonin: from the roots and the commercial root extract of lithospermum erythrorhizon
tigogenin hexasaccharide-1: isolated from the fresh bulbs of camassia cusickii
tigogenin hexasaccharide-2: isolated from the fresh bulbs of camassia cusickii
tilS protein, E coli: an rna-modifying enzyme that governs both the codon and amino acid specificities of isoleucine trna
tilavonemab: a humanized anti-tau antibody for the treatment of alzheimer's disease and tauopathies
tiletamine, zolazepam drug combination: anesthetic composed of tiletamine & zolazepam (flupyrazapone); diazepinone tranquilizer
tiliaflan: from the flowers of lime trees; slightly inhibits formation of carcinogenic nitroso cpds
tiliamosine: a bis, benzylisoquinoline alkaloid isolated from tiliacora acuminata
tilianin: from several medicinal plants including agastache rugosa and dracocephalum moldavia
tiliarine: rn given for (4as-(4ar*,16ar*))-isomer; an antineoplastic agent
tilifodiolide: isolate from salvia tiliifolia; has anti-inflammatory and anti-nociceptive properties
tilimycin: a pyrrolobenzodiazepine toxin produced by klebsiella oxytoca which induces apoptosis in epithelial cells and contributes to the development of colitis
tilitriandrine: a bisbenzylisoquinoline alkaloid from tiliacora triandra
tilivalline: a pyrrolo(1,4)benzodiazepine derivative with an 11-beta-indole substituent; found in secondary metabolites of klebsiella pneumoniae var. oxytoca; ; rn given refers to (11s-cis)-isomer
tillam sulfoxide: inhibits fatty acid elongation; believed to be the active herbicidal form of tillam
tillandsinone: from the leaves of tillandsia fasciculata (bromeliaceae)
tiludronic acid: a bone resorption inhibitor; an antihypercalcemic agent; used in the tratment of paget's disease; used in the treatment and prevention of osteoporosis
timegadine: first source states that sr 1368 is synonym for cpd; sr 1368 is a different cpd in chemline
timolimfotropina: induced increase in glycemia & liver glycogen content and a decrease in glycogen-phosphorylase activity in rats; similar to leucotrofina
timolumab: monoclonal antibody against vascular adhesion protein-1 (vap-1)
timopregnane B: from the rhizome of anemarrhena asphodeloides
timosaponin AIII: nootropic agent from anemarrhena asphodeloides
timosaponin B-II: from anemarrhenae asphodeloides; improved memory and learning dysfunction induced by cerebral ischemia in rats
timosaponin BIII: an anti-allergy agent isolated from anemarrhena asphodeloides
timosaponin D: an anti-allergy agent isolated from anemarrhena asphodeloides
tin dibutylditrifluoroacetate: used in treating silicate glass to produce electrical conducting & radioprotective films
tin mesoporphyrin: ; rn given refers to dihydrogen, (sp-4-2)-isomer; rn for cpd without isomeric designation not available 5/88
tin protein, Drosophila: affects cell fates in mesoderm; isolated from drosophila; amino acid ; do not confuse with msh2 protein, an muts homolog 2 protein
tin-2,4-diiododeuterporphyrin: ; rn given refers to dihydrogen, (sp-4-2)-isomer; rn for cpd without isomeric designation not available 5/88
tinc protein, Drosophila: expressed in cardioblasts; refseq nm_176509
ting-chih-wan: contains ginseng radix, polygala radix, ziziphus seedmen, biotae seedmen and poria
tingenin B: isolated from glyptopetalum sclerocarpaum; ; rn given refers to (20beta,22beta)-isomer; rn for cpd without isomeric designation not available 11/90; rn is for tingenin a (8/2001)
tinnevellin 8-O-glucoside: isolated from cassia angustifolia (leguminosae)
tinofedrine: d 8955 & novocebrin refer to hcl; rn given refers to parent cpd
tinoridine: proposed anti-inflammatory agent; minor descriptor (75-86); on-line & index medicus seach pyridines (75-86)
tinospinoside A: from tinospora sagittata (oliv.) gagnep
tinospinoside B: from tinospora sagittata (oliv.) gagnep
tinospinoside C: from tinospora sagittata (oliv.) gagnep
tio protein, Drosophila: involved in the embryonic development; refseq nm_079994
tiodazosin levulinate: tiodazosin compounded with levulinic acid
tipA protein, Streptomyces: one of several proteins induced by thiostrepton and other thiopeptide antibiotics; isolated from streptomyces lividans and streptomyces coelicolor; has been sequenced
tipAS protein, Streptomyces: isolated from streptomyces lividans and streptomyces coelicolor; a thiostrepton-induced transcriptional activator protein; has two isoforms, long/tipa-l and short/tipa-s, are produced by alternative initiation; amino acid sequence given in first source
tipapkinogen sovacivec vaccine: hpv vaccine in cervical intraepithelial neoplasia grades 2 and 3
tipin protein, Xenopus: interacts with tim1; required for repair of stalled dna replication forks; genbank ab208777
tiqueside: reduces intestinal cholesterol absorption with little change in hdl-cholesterol levels & without interfering with enterohepatic bile acid recirculation
tiquinamide: inhibitor of gastric acid secretion; rn given refers to parent cpd
tirabrutinib: a bruton tyrosine kinase with antineoplastic activity; in phase i clinical trials (2016)
tiracoxib: the combined administration of tiracoxib with probucol significantly inhibited the tumor growth. the angiogenesis was markedly reduced; no further information available 1/31/2001
tirandalydigin: ; isolated from streptomyces strain ab 1006a-9
tirilazad: a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; ; tradename freedox
tirucalla-5(6),7,24 (25)-triene-3-dion-21,16-olide: from the barks of melia azedarach
tisagenlecleucel: anti-cd19 chimeric antigen receptor (car) t-cell therapy for treatment of b-cell lymphoblastic leukemia
tisotumab vedotin: a fully human monoclonal antibody specific for tissue factor conjugated to the microtubule-disrupting agent monomethyl auristatin e (mmae) via a protease-cleavable valine-citrulline linker
tissue PA-herstatin adenovirus fusion protein: an effective therapeutic tool for control of inflammatory disorders involving an angiogenic component
tissue plasminogen activator-(staphylococcal A, B fragment) dimer: can rapidly reestablish cerebral perfusion after cerebral embolization
tissue polypeptide specific antigen: do not confuse with tpa antigen (measures a different cytokeratin in serum)
tissue-factor-pathway inhibitor 2: glycoprotein containing 20% carbohydrate which moves as a beta(1) globulin on electrophoresis; mw 36,000; tfpi-2 is an important regulator of the extrinsic pathway of blood coagulation; a factor viia antagonist; present in placenta, maternal serum in late pregnancy, liver, heart, pancreas, and other tissues; a serine protease inhibitor; genbank l27624 (human); refseq nm_006528 (human), nm_009364 (mouse)
titanium alloy (TiNb13Zr13): a surface-hardened, low-modulus, corrosion-resistant titanium alloy; used for total hip arthroplasty
titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; rn given refers to titanium oxide (tio2)
titanium dioxide, zinc peroxide, zinc oxide drug combination: ointment containg zinc oxide, zinc peroxides & titanium oxide; used in the treatment of leg ulcers
titanium nickelide: alloy of titanium and nickel used for bone fractures; rn given refers to 1:1 alloy; ni-ti memory alloys used as pseudoelastic canine retraction spring; do not confuse with nitinol which includes not only ni-ti alloys but also co-ni-ti alloys
titanium oxide-human serum albumin: radiopharmaceutical labeled with titanium-45
titanium(IV) transferrin: formed by reaction of human serum apotransferrin with titanium complex
titanium-nickel-cobalt alloy: an alloy used to fix mandible fractures
titanium-nitride-oxide: significantly reduces neointimal hyperplasia in stainless steel stents
titanocene bis(4-aminothiophenolate): ; rn given refers to dihydrochloride
titanoreine: suppository containing carrageenan, titanium oxide, zinc oxide, talc & excipient semisynthetic glycerides
tityustoxin IV: a short chain four-disulfide-bridged neurotoxin from tityus serrulatus; amino acid
tityustoxin V: an alpha-toxin from brazilian scorpion, tityus serrulatus; 64 amino acids; amino acid sequence given in first source
tityustoxin VII: isolated from tityus serrulatus; n-terminal amino acid
tityustoxin-19, Tityus serrulatus: ts19 fragment ii, long-chain potassium channel toxin from tityus serrulatus venom
tizolemide: hoe 740 refers to mono-hcl; rn given refers to parent cpd
tj protein, Drosophila: a large maf factor & an ortholog of the atypical basic leu zipper transcription factors c-maf and mafb/kreisler in vertebrates; a critical modulator of the adhesive properties of somatic cells, facilitating germline-soma interactions that are essential for germ cell differentiation; refseq nm_136125
tlx3a protein, zebrafish: a hox11-like gene from early differentiating embryonic neurons and cranial sensory ganglia of the embryo; amino acid ; genbank ay045753
tmRNA: a small stable rna, first found in e. coli, since then detected in many bacteria; renamed tmrna to reflect its trna-like and m-rna like properties
tmc-2 protein, C elegans: refseq nm_001348601.1
tmem-39 protein, C elegans: no refseq available; ortholog of tmem39a
tmrB protein, Bacillus subtilis: amino acid sequence given in first source; isolated from bacillus subtilis; an atp-binding protein responsible for tunicamycin-resistance of bacillus subtilis
tnaC protein, E coli: involved in regulation of tryptophanase operon; 24 amino acis residues; amino acid
tnfsf10l protein, Xenopus: a ligand of the death receptor-ms; genbank ab496422
tnn protein, zebrafish: a member of the tenascin family from zebrafish; amino acid ; refseq nm_131036
tnnt2a protein, zebrafish: muscle-type troponin t gene in zebrafish; amino acid sequence in frst source; refseq nm_152893
tnpI recombinase: from tn2i and related beta-lactamase transposons
tns-1 protein, C elegans: refseq nm_001318270.1
tob1a protein, zebrafish: putative anti-proliferative protein; genbank ay528679
tobacco anionic peroxidase: has been shown to oxidize a number of significant plant secondary cpds in vitro; from nicotiana tabacum; expressed in highest level in lignifying & epidermal tissue; aa sequence known; genbank l02124
tobacco mosaic virus replicase: possesses methyltransferase, helicase-like, and polymerase domains; involved in resistance of plants to tmv; transgenic plants expressing additional insertion (an is10-like transposable element) in the tmv replicase gene are resistant to tmv
tobacco protein kinase NPK5: 65% identical to snf1 protein kinase; maybe involved in sugar metabolism of plants; isolated from tobacco; amino acid ; genbank d26602
tobanum: tobanum is for (+-)-isomer, hcl salt; rn given refers to parent cpd
tobramycin adenylyltransferase: substrate aminoglycosides may be replaced by specific antibiotics
tochibanan A: from panax japonicus; shows reticuloendothelial-potentiating activity; mw 23 kda; linear beta-1-4-d-galactan
tochibanan B: from panax japonicus; mw 40 kda; consists of galactose, arabinose, glucose, & galacturonic acid; shows reticuloendothelial-potentiating acitivity
tocilizumab: a humanised anti-interleukin-6 receptor monoclonal antibody
tocopherol cyclase: catalyzes cyclization of phytyl-hydroquinone to gamma-tocopherol; isolated from the blue-green alga anabaena variabilis
tocopherol-associated protein, mouse: expressed in mast cells & predominantly localized in the cytoplasm
tocopheroxy radical: rn given refers to radical ion (1+), (2r-(2r*(4r*,8r*)))-isomer; rn for cpd without isomeric designation not available 12/90
todarepsin, Todarodes pacificus: from hepatopancreas of japanese common squid (todarodes pacificus); genbank ab106552
toddaculin: from toddalia asiatica, induces differentiation and apoptosis in u-937 leukemic cells
toddalin A: phosphodiesterase-4 inhibitor from toddalia asiatica
tof protein, Human T-lymphotropic virus 1: 241 amino acid residues; accumulates in nucleoli of transfected cells; amino acid sequence given in first source
tofersen: antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (sod1) messenger rna to reduce sod1 protein synthesis
tofisoline: rn is from cas registry handbook, (1965-1971) & is for hydroxide, inner salt; rn not in chemline 8/83
tofisopam: structure; dextofisopam is the r-enantiomer of tofisopam & antidiarrheal
togal: contains 1.5 mg quinine.di-hcl, 42 mg lithium citrate, 250 mg acetylsalicylic acid
toh1 protein, S cerevisiae: refseq nm_001181604.2
tokaracetin: trimeresurus tokarensis beta-subunit n-terminal fragment; amino acid sequence given in first source
tokaradine A: isolated from pseudoceratina purpurea, lethal to the crab hemigrapsus sanguineus
tokaratoxin 1: from trimeresurus tokarensis; posses both hemorrhagic & proteolytic activities
tokaratoxin 2: from trimeresurus tokarensis; posses both hemorrhagic & proteolytic activities
toki-shakuyaku-san: a mixture of peony root, atractylodes lancea rhizome, alisma rhizome, hoelen (poria), cnidium rhizome and angelica root in the ratio 4:4:4:4:3:3
tokuyama rebase fast II: made from 1,9-nonanediol dimethacrylate and 2-(acetoacetoxy) ethyl methacrylate
tolA protein, E coli: from e coli; amino acid sequence given in first source; 421 amino acid residues; found with the periplasmic components of the cell
tolB protein, E coli: from e coli; amino acid sequence given in first source; 431 amino acid residues; associated with the membrane fractions
tolC protein, E coli: required for proper expression of outer membrane protein genes such as ompf, nmpc, protein 2, hemolysin, colicin v, or colicin e1; may be specialized for signal sequence independent, extracellular secretion in gram-negative bacteria; binds with acra or acrb to form efflux channel
tolQ protein, E coli: from e coli; are involved in uptake of group a colicins & infection by filamentous bacteriophages; homologous to exbb protein; amino acid sequence given in first source
tolR protein, E coli: from e coli; involved in uptake of group a colicins & infection by filamentous bacteriophages; homologous to exbd protein; amino acid sequence given in first source
tolaasin protein, Pseudomonas tolaasii: a lipodepsipeptide; amino acid sequence given in first source; from p. tolaasii
tolafentrine: a mixed-type phosphodiesterase (pde) iii/iv inhibitor
tolbutamide 4-hydroxylase: several isoenzymes of cytochrome p-450 catalyze this reaction, including cyp2c8, cyp2c9 and cyp2c10
tolclofos-methyl: a fungicide used in the cultivation of cotton, sugar beets, and ornamental plants
toliprolol: was mh 1975-92 (see under propanolamines 1981-90, was doberol see under propanolamines 1975-80); koe 592 was see toliprolol 1975-92; use propanolamines to search toliprolol 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris
toluene 2,3-dioxygenase: catalyzes conversion of toluene to cis-3-methyl-3,5-cyclohexane-1,2-diol
toluene 2-xylene monooxygenase: enzyme with broad substrate range and relaxed regiospecificity; catalyzes conversion of toluene to 2-, 3-, or 4-hydroxytoluene, among other reactions; also acts on o-xylene; isolated from pseudomonas stutzeri
toluene dioxygenase: resolved into 3 protein components; maximum activity dependent on presence of ferrous iron & nadh; see also record for toluene 2,3-dioxygenase; forms benzyl alcohol
toluene ortho-monooxygenase: enzyme from pseudomonas sp. strain js150 acts on both toluene and benzene; amino acid sequence has been determined; also hydroxylates cresol to 3-methylcatechol
toluene-3-monooxygenase: degrades benzene & related aromatic hydrocarbons in pseudomonas pickettii
toluene-4-monooxygenase: enzyme system contains 3 protein components; the reconstituted enzyme system catalyzes the oxidation of toluene to p-cresol by an nad(p)h-dependent monooxygenation reaction in which one atom of molecular oxygen in incorporated into the hydroxyl group cresol
tolybyssidin A: isolated from the culture medium of mass cultured cyanobacterium tolypothrix byssoidea
tolybyssidin B: isolated from the culture medium of mass cultured cyanobacterium tolypothrix byssoidea
tolypocladin: a pigmented metabolite derived from the mycelium of tolypocladium inflatum
tolypocladone A: from an endolichenic fungus tolypocladium sp.
tolypocladone B: from an endolichenic fungus tolypocladium sp.
tolypodiol: a diterpenoid from the cyanobacterium tolypothrix nodosa
tolyporphin: a cyanobacterial natural product; isolated from extracts of tolypothrix nodosa; reverses p-glycoprotein-mediated multiple drug resistance
tolypyridone A: alkaloid from the endolichenic fungus, tolypocladium cylindrosporum
tomaralimab: an anti-toll-like receptor 2 antibody in phase i clinical trials (2013)
tomatinase: catalyzes the hydrolysis of alpha-tomatine into its nonfungitoxic forms, tomatidine and beta-lycotetraose
tomato anionic peroxidase 1: product of tap1 gene; do not confuse with rat1 protein from saccharomyces cerevisiae or with tap-1 protein known as ring4 protein which is an atp-binding cassette transporter; has been sequenced
tomato meiotic proteinase: involved in microsporogenesis; absence in the plant may be compensated for by other proteinases; amino acid
tomb protein, Drosophila: a testis-specific protein and component of the tmac meiotic arrest complex; has been sequenced; refseq nm_135092
tomenphantin A: a cytotoxic germacranolides from elephantopus tomentosus
tomenphantin B: a cytotoxic germacranolides from elephantopus tomentosus
tomentodiplacone B: antineoplastic agent isolated from paulownia tomentosa
tomentoside A: a nor-triterpene glycoside from peruvian "uña de gato" (uncaria tomentosa)
tomentoside B: a nor-triterpene glycoside from peruvian "uña de gato" (uncaria tomentosa)
tomicide: bacteriocin-like from streptococcus, sp., thom-1606; do not confuse with tomicide z 50 see zinc pyrithione
tomivosertib: a selective translation regulator and is part of a new class of cancer treatments known as immunotherapies that are designed to harness the body's own immune system in fighting cancer. eft508 is a highly potent and selective, oral inhibitor of mnk1 and mnk2 (mnk1/2)
tomm20b protein, zebrafish: an outer mitochondrial membrane receptor; refseq nm_001002698
tomocinon: an antineoplastic agent with antiausterity activity; isolated from caesalpinia sappan
tomosyn protein, mouse: syntaxin-1-binding protein; component of the synaptic vesicle docking or snare complex; refseq xm_125517
tonazocine: rn given refers to (2alpha,6alpha,11s*)-(+-)-isomer
tong luo hua shi: for treatment of rheumatoid arthritis; contains: salvia miltiorrhiza, ephedra intermedia, sabina przewalskii, myricaria paniculata, artemisia sieversiana, astragalus membranaceus, and rhododendron anthopogonoides
tong-qiao-huo-xue: used to treat cerebral ischemia; prepared from moschus berezovskii, carthamus tinctorius, ligusticum chuanxiong, prunus persica, paeonia veitchii, ziziphus jujube, and scallion
tongdan: used to treat primary biliary cirrhosis; consists of pericarpium trichosanthis, fasciculus vascularis luffae, retinervus citri fructus, pericarpium citri reticulatae viride, radix rehmanniae
tongdatang: may be useful in treating antipsychotic-induced galactorrhea-amenorrhea syndrome
tongkyutang: an oriental herbal prescription, which has been successfully applied for the treatment of allergic disorders, mainly allergic-rhinitis in clinical medicine; contains radix sp., rhizoma sp., herba ephedrae, pericarpium zanthoxyli & bulbus allii fistulosi
tongmai formula: consists of three medical herbals, i.e. salviase miltiorrhizae (danshen), puerariae lobatae (gegen), and ligusticum chuanxiong (chuanxiong)
tongmai yizhi: has neuroprotective activity; used to treat senile dementia; consists of fructus alipiniae oxyphyllae, radix polygoni multiflori preparata (root, steamed with soya-bean milk), rhizoma ligustici chuangxiong, borneolum syntheticum, radix polygalae, and whitmania pigra whitman
tongmaiyangxin: chinese herbal drug that consists of 11 herbs, including rehmannia glutinosa libosch, spatholobus suberectus dumn, ophiopogon japonicus, glycyrrhiza uralensis fisch, polygonum multiflorum thunb, equus asinus l, schisandra chinensis, codonopsis pilosula, chinemys reevesii, ziziphus jujuba mill and cinnamomum cassia presl
tongqiaohuoxue decoction: a water extract of a mixture of eight species of medicinal herbs, has been used for the treatment of blood stasis and hypercoagulation
tongsaimai: consists of astragalus membranaceus (fisch.) bunge, codonopsis pilosula (franch.) nannf, angelica sinensis (oliv.) diels, dendrobium nobile lindl, lonicera japonica thunb, scrophularia aestivalis griseb, achyranthes bidentata blume, and glycyrrhiza uralensis fisch; has a protective effect on focal cerebral ischemia and used to treat thromboangiitis in clinical practice
tongue cancer resistance-associated protein 1, human: largely cytoplasmic protein that mediates resistance to cisplatin; genbank ef363480
tongxie-yaofang: composed of bai zhu, shao yao, chen pi and fang feng; inhibits colonic contraction in rats
tonin: tissue kallikrein found in rats; tonin was see kininase ii 1984-1993; use kininase ii to search tonin 1984-1993
tonkinecin: an acetogenin from uvaria tonkinesis; ; do not confuse with tonkinelin
tonkinelin: an annonaceous acetogenin; isolated from uvaria tonkinensis; ; do not confuse with tonkinecin
tonoplast intrinsic protein 3, Arabidopsis: refseq nm_105978
tonoplast intrinsic protein, plant: 27 kda protein with 6 membrane-spanning domains present in embryos and vegetative tissues; amino acid sequence of the polypeptide segment comprising the 6th membrane-spanning domain given in first source
too many mouths protein, Arabidopsis: a leucine-rich repeat protein; genbank nc003070
tooeleite: a rare ferric arsenite sulfate oxy-hydroxide mineral formed by bacteria in the acid mine drainage
toonaciliatin M: isolated from toona ciliata; showed moderate antifungal activity against trichophyton rubrum
toonayunnanin: from the leaves of toona ciliata var. yunnanensis
toosenoside A: isolated from a n-buoh partition of the fruits of melia toosendan
topacal C-5: a casein phosphoprotein-amorphous calcium phosphate dental cream without fluoride; used as an enamel improving cream
topi protein, Drosophila: a testis-specific meiotic arrest gene product that binds comr; amino acid ; refseq nm_141688
topless protein, Arabidopsis: regulates apical embryonic fate in arabidopsis; has been sequenced
topless-related 1 protein, Arabidopsis: refseq nm_179582
toposome glycoprotein complex: 22s glycoprotein complex from paracentrotus lividus sea urchin embryo, that has been called toposome
topostatin: isolated from the culture filtrate of thermomonospora alba strain no.1520
topramezone: corn herbicide, an inhibitor of 4-hydroxyphenylpyruvate dioxygenase
toprina: protein flour derived from yeast cultivated on n-alkanes & used in animal feed
topsentin A: number of carbony group = 1 for topsentin a and no carbonyl group for nortopsentin b and d
topsentinol K trisulfate: from the marine sponge topsentia sp.
tor protein, Drosophila: a receptor tyrosine kinase that accumulates uniformly along the entire surface of the embryo but is activated only in the vicinity of the poles; amino acid sequence has been determined; don't confuse with target of rapamycin protein, drosophila (also listed as tor); refseq nm_001103742
toralactone: rn & nl from 9th ci; cpd not in chemline 8/83
toralactone-9-O-gentiobioside: isolated from the seeds of cassia tora
toralizumab: a humanized mab against cd154, the ligand for cd40 also called cd40l or gp39; for potential treatment of several autoimmune diseases; phase ii clinical trials 1/2003; rn in first source
torcetrapib: inhibits cholesteryl ester transfer protein; modest increase in blood pressure led to reevaluation
torilolone 8-O-beta-D-glucopyranoside: antineoplastic from the fruits of daucus carota
torin: erythrocyte membrane protein which is single polypeptide of mw 20,000
torosachrysone 8-O-6''-malonyl gentiobioside: from the seed of cassia torosa
torrubiellin A: isolated from the leafhopper pathogenic fungus torrubiella sp. bcc 28517
torrubiellin B: isolated from the leafhopper pathogenic fungus torrubiella sp. bcc 28517
torrubiellone A: from the spider pathogenic fungus torrubiella sp. bcc 2165; exhibited antimalarial activity and weak cytotoxic activity
torrubiellone E: an antimalarial from the spider pathogenic fungus torrubiella longissima bcc 2022
torrubiellutin C: an antineoplastic agent isolated from torrubiella luteorostrata
tosA protein, E coli: the presence of repeat-in-toxin gene tosa predicts successful colonization of the urinary tract
tositumomab I-131: iodine-131-labeled anti-cd20 antibody for radioimmunotherapy of b-cell non-hodgkin's lymphoma
tosyl N-(acetyl)-thioglucosamine: inhibits hexosaminidase c
tosyl-glycyl-prolyl-arginyl-4-methylcoumaryl-7-amide: recommended for antithrombin iii photometry as a substrate
tosyl-glycyl-prolyl-arginyl-5-amino-2-nitrobenzoic acid: a chromogenic substrate used to execute prothrombin time
tosylarginine methyl ester hydrolase: protease from sea urchin (arbacia punctulata) eggs; fertilization in the sea urchin is accompanied by the release of this protease from eggs into the surrounding seawater; enzyme uses tame as substrate; used as a measure of trypsin-like activity; tryptase (formerly here) is mast cell tryptase (ec 3.4.21.59)
tosylserylglycine methyl ester: tosyl-protected peptide containing amino acids with polar side-chains
tosylthreonylglycine methyl ester: tosyl-protected peptide containg amino acids with polar side-chains
totoet: ; do not confuse with toto, by which name this term is also known
totopotensamide A: from a mollusk-associated bacterium streptomyces sp.
totopotensamide B: from a mollusk-associated bacterium streptomyces sp.
tounongsan: has antineoplastic activity; consists of radix astragali mongolici, rhizoma ligusticum chuanxiong, angelica sinensis, spina gleditsiae, and squama manis
tournefolic acid B methyl ester: blocks the caspase cascade and reduces ros accumulation; has neuroprotective activity
tousled protein, Arabidopsis: required for leaf & flower development; mw 78 kda; amino acid sequence given in first source
tousled-like kinase, Trypanosoma brucei: the five-protein complex cpc-tbtlk1-tbkin-b plays key roles in regulating chromosome segregation in the early phase of mitosis
toxB protein, E coli: involved in the full adherence phenotype; has been sequenced
toxR protein, Vibrio cholerae: transmembrane, dna-binding protein that positively controls transcription of the genes for cholera toxin, tcp pili, & other proteins important in cholera pathogenesis
toxR protein, bacteria: transmembrane, dna-binding protein that positively controls transcription
toxic shock syndrome toxin-1 (58-78): 21 amino acid synthetic peptide sequence given in first source
toxicarioside A: from antiaristoxicaria (pers.) lesch (moraceae)
toxicarioside N: extracted from antiaris toxicaria; induces apoptosis in human gastric cancer cells
toxicodenane A: ; from the resin of toxicodendron vernicifluum
toxicodenane B: ; from the resin of toxicodendron vernicifluum
toxicodenane C: ; from the resin of toxicodendron vernicifluum
toxin 10, Centruroides: an insect-specific toxin from c. noxius; amino acid sequence given in first source; genbank y08270
toxin 11, Centruroides noxius: from the venom of the mexican scorpion centruroides noxius hoffmann; it contains 63 amino acid residues and is stabilized by four disulphide bridges; amino acid
toxin 12, Centruroides noxius: from the mexican scorpion centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity; amino acid
toxin 14, Buthus occitanus: from the venom of a vietnamese scorpion, buthus occitanus sp.; 35 amino acid residues and three disulfide bridges, mw 3843 da; amino acid
toxin 1593 (Bacillus sphaericus): toxic to mosquito larvae
toxin 2, Centruroides noxius: contains 66 amino acids; amino acid sequence given in first source
toxin 3, Centruroides noxius: contains 66 amino acids; amino acid sequence given in first source
toxin A (Pseudomonas): from pseudomonas aeruginosa; potent inhibitor of eukaryotic protein synthesis
toxin A, Photorhabdus: isolated from photorhabdus luminescens; n-terminal amino acid
toxin Aa e, Acanthophis: from venom of australian death adder, a. antarcticus; aa e1 & aa e2 are isoforms; amino acid sequence given in first source
toxin B, Photorhabdus: isolated from photorhabdus luminescens; n-terminal amino acid
toxin BgK: a 37 amino acid toxin from sea anemone, bunodosoma granulifera; amino acid sequence given in first source
toxin C(13)S(1)C(3): toxin from d angusticeps venom containing 57 amino acids; acts as protease inhibitor
toxin C(13)S(2)C(3): toxin from d angusticeps venom containing 59 amino acids; acts as protease inhibitor
toxin FS2: a 60 amino acid residues peptide isolated from the venom of black mamba snake, dendroaspis polyepis polyepis; amino acid sequence given in first source
toxin I (Anemonia sulcata): do not confuse with alterotoxin i which is also abbreviated atx i
toxin II (Anemonia sulcata): toxic polypeptide closely related to anthopleurin a with potent cardiac stimulant activity from anemonia sulcata; do not confuse with altertoxin ii which is also abbreviated atx ii
toxin III (Anemonia sulcata): polypeptide with 27 amino acid residues; see also record for cytolysin iii (stoichactis helianthus)
toxin IV (Anemonia sulcata): differs only from toxin iii (anemonia sulcata) in the lack of 2 amino acid residues (lys-val) that occur at the c-terminal of toxin iii
toxin L, Clostridium sordellii: cytotoxin from clostridium sordellii
toxin S4C8: from dendroaspis jamesoni kaimosae venom
toxin SA-H, Scatophagus argus: haemorrhagic protein toxin from the indian venomous butterfish (scatophagus argus, linn) sting extract; produced severe haemorrhage on stomach wall; mw about 18 kda
toxin TsTX-VI: from tityus serrulatus; amino acid sequence given in first source
toxin Tskapa-maurotoxin: a synthetic 38-mer chimera of mtx (maurotoxin) derived from maurotoxin (scorpio maurus palmatus) and tsk (toxin tskapa from tityus serrulatus) scorpion toxins
toxin V (Anemonia sulcata): polypeptide with 46 amino acid residues; used in studies with na+channel
toxin VI (Scorpion venom): toxin from scorpion centruroides sculpturatus venom
toxin VII: beta-toxin from tityus serrulatus consisting of 61 amino acids
toxin-1, Chironex fleckeri: major venom protein from the box jellyfish, c fleckeri; genbank ef636902
toxin-2, Chironex fleckeri: major venom protein from the box jellyfish, c fleckeri; genbank ef636903
toxin-LR: leucine- & arginine-containing pentapeptide found in cyanobacterium microcystis aeruginosa; induces atypical pulmonary thrombosis
toxiusol: a natural product isolated for the red sea sponge toxiclona toxius; a general inhibitor of retroviral and cellular dna polymerases
toxofactor: glycoprotein mw 50,000-100,000; cell-free toxin-like material; important component in pathogenesis of congenital toxoplasmosis; toxic & teratogenic to mice
toxofilin protein, Toxoplasma gondii: actin-binding protein from toxoplasma gondii, sequesters actin monomers and caps actin filaments; genbank aj132777
toxophallin, Amanita phalloides: a highly cytotoxic protein from the fruit body of the death cap amanita phalloides mushroom; genbank gu220069
toxopyrimidine: pyridoxine antagonist; rn given refers to parent cpd
toy protein, Drosophila: a pax-6 gene product isolated from drosophila; amino acid ; refseq nm_079899
toyocamycin nitrile hydrolase: catalyzes the hydrolysis of the nitrile group of toyocamycin to the amide group of sangivamycin
tozasertib: a potent and selective small-molecule inhibitor of the aurora kinases, suppresses tumor growth
tozuleristide: a tumor contrast agent that consists of 36-amino-acid peptide derived from the scorpion venom chlorotoxin conjuated to indocyanine green
tph2 protein, rat: the circadian 5-ht synthesis within the serotonergic neurons projecting to the circadian system might be explained by the rhythmic transcription of the tph2 gene in raphe nuclei
tph2 protein, zebrafish: expressed in serotonergic raphe neurons, similar to tph genes in mammalian species; also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin; amino acid ; refseq nm_214795