NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
ethylenediamine: rn given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical
ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid): synthetic iron chelator; rn given refers to parent cpd; structure in 3rd source
ethylenediamine-N,N'-di-2-propanoic acid diisoamyl ester: a ligand of some organoplatinum antineoplastic agents
ethylenediaminetetrakis(methylphosphonic) acid: do not confuse with quadrol, which is also known as edtp
ethyleneglycol bis(succinimidyl succinate)hydroxyethylethylenediamine triacetic acid: enzyme metabolizable bifunctional chelate to which monoclonal antibodies can be attached
ethyleneglycol bis(sulfosuccinimidyl succinate): a cross-linking agent; tartrate synonym given by authors but is incorrect
ethylglyoxal bis(thiosemicarbazonato)copper(II): binds serum albumin
ethylhexylglycerin: an emollient solvent with antimicrobial activity
ethylidene-alpha,omega-bis(benzyldimethylammonium bromide): used to form a pseudo gemini surfactant with sodium stearate
ethylmalonate-semialdehyde dehydrogenase: forms butyryl-coa
ethylmalonic acid: don't confuse with diethyl malonate, which is a diester
ethylmalonyl-CoA mutase, Rhodobacter sphaeroides: a b12-dependent mutase
ethylmalonyl-coenzyme A: product of methylmalonyl-coa mutase rearrangement of glutaryl-coa
ethylmorphine-6-glucuronide: a major metabolite of ethylmorphine in man
ethylphenylepoxygeranyl ether: used as an insecticide; minor descriptor (75-85); on-line & index medicus search terpenes (75-85); rn given refers to cpd without isomeric designation
ethyltyrosyl-arginyl-phenylalanyl-glycine ethyl ester: exhibited exceedingly potent antinociceptive activity in mice
ethyltyrosylarginine methyl ester: possesses dose-dependent antinociceptive activity
ethynyl-4-fluorobenzene: a reagent for fluorine radiolabeling
eticlopride: blocks dopamine-d2 binding sites; ; rn given refers to (s)-isomer
etienic acid: inchikey: yqacaxhkqzceoi-udcwsgshsa-n
etiocholenic acid: rn given refers to (3 beta,17 beta)-isomer
etisulergine: rn given refers to parent cpd; cq 32084 is synonomous to hcl
etnangien: a macrolide-polyene antibiotic from sorangium cellulosum that inhibits nucleic acid polymerases
etokthonotoxin: a cyanobacterial neurotoxin produced by aetokthonos hydrillicola. it is a pentabrominated biindole alkaloid linked to avian vacuolar myelinopathy first reported in bald eagles (haliaeetus leucocephalus) at degray lake, arkansas
etomoxiryl-coenzyme A: inhibits mitochondrial carnitine palmitoyltransferase and other carnitine acyltransferases
etonitazene: was heading 1979-94 (see under benzimidazoles 1979-90); etonitazin was see etonitazene 1979-94; use benzimidazoles to search etonitazene 1979-94; narcotic analgesic similar to morphine in action; used mainly to study narcotic habituation, tolerance, and withdrawal in laboratory animals
etonogestrel: metabolite of desogestrel; ; implanon: implant containing etonogestrel (3-keto-desogestrel)
etoxadrol: was heading 1975-94 (see under piperidines 1975-90); use piperidines to search etoxadrol 1975-90; dissociative anesthetic with some cardiovascular effects
etoxadrol-2-isothiocyanate: affinity ligand for phencyclidine-binding site; ; etoxadrol/*aa (pi 88-94)
etp1 protein, S pombe: an internal electron transfer protein from fission yeast; identical to cox15 from s. cerevisiae; has been sequenced
etrolizumab: selectively blocks lymphocyte homing to the gastrointestinal tract without affecting lymphocyte trafficking to non-mucosal tissues
ettringite: synthesis of ettringite from acid wastewaters of the aluminium anodising industry is a possible route of reducing the emissions to the environment, recovering at the same time resource materials as a useful marketable mineral
euadesma-4-ene-1beta,15-diol: from the rhizomes of homalomena occulta
eucaglobulin: complex of gallotannin and monoterpene from leaves of eucaloptus globulus
eucapsitrione: an anti-mycobacterium tuberculosis cpd from the cultured freshwater cyanobacterium eucapsis sp.
eucarobustol E: a formyl-phloroglucinol meroterpenoid derived from eucalyptus robusta; has antibiofilm activity against candida albicans
euchrenone b10: inhibitor of sodium-hydrogen exchanger; isolated from the bark of erythrina variegata
euchrestaflavanone B: may have antineoplastic activity; isolated from cudrania tricuspidata
eucommicin A: a selective inhibitor of cancer stem cells from eucommia ulmoides
eucoriol: taktosan salbe is a water-in-oil emulsion with eucoriol as active ingredient; used as a skin barrier cream
eudebeiolide D: from salvia plebeia, inhibits il-6-induced stat3 activation
eudesma-4(15),7(11)-dien-8alpha,12-ether: from the processed rhizomes of atractylodes macrocephala
eudesmadiene-12,6-olide: isolated from frullania muscicol
eudesmin: rn refers to (1r-(1alpha,3aalpha,4alpha,6aalpha))-isomer; ; very similar to pinoresinol
eudistidine C: isolated from eudistoma sp. and consists of a tetracyclic core structure with a p-methoxyphenyl group and a phenol-substituted aminoimidazole moiety; has antimalarial activity against plasmodium falciparum
eudistomidin G: isolated from the okinawan tunicate eudistoma glaucus
eudistomin E: structure known; isolated from the marine tunicate eudistoma album
eudistomin T: isolated from the bermudian tunicate eudistoma olivaceum
eudistomin U: an alkaloid from the carribean ascidian lissoclinum fragile
eudistomin Y6: beta-carboline alkaloid from a korean tunicate eudistoma sp. that exhibited moderate antibacterial activity against gram-positive bacteria staphylococcus epidermis and bacillus subtilis without cytotoxicity
eugenol O-methyltransferase: forms methyleugenol and isomethyleugenol from eugenol and isoeugenol, respectively
eugenol dehydrogenase: a flavocytochrome enzyme that catalyzes enantioselective hydroxylation of p-alkylphenols; converts eugenol to coniferyl alcohol
eugenol hydroxylase: a flavocytochrome c enzyme from pseudomonas that converts eugenol to coniferyl alcohol; ehya and ehyb are structural genes for eugenol hydroxylase; genbank aj243941
eugenol oxidase, Rhodococcus: catalyzes conversion of eugenol, water, and oxygen to hydrogen peroxide and coniferyl alcohol; amino acid
eugenol synthase, Ocimum basilium: catalyzes the conversion of coniferyl acetate to eugenol
eugenosedin-A: antioxidant; protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice
eugenyl 4''-O-acetyl-beta-rutinoside: from the basidiomycete lactarius deliciosus
euglobal G1: inhibits epstein-barr virus activation; isolated from eucalyptus grandis
euglobal G2: a pinene monoterpene linked to a phloroglucinol; inhibits epstein-barr virus activation; isolated from eucalyptus grandis
euglobal G3: a phloroglucinol linked pinane type monoterpene; inhibits epstein-barr virus activation; isolated from eucalyptus grandis
euglobal In 1: has an acylphloroglucinol-sesquiterpene structure; isolated from the leaves of eucalyptus incrassata
euhalothece-362: a red-shifted mycosporine-like amino acid, from a halophilic cyanobacterium (euhalothece sp.)
eujavanicin A: antifungal cyclic depsipeptide from eupenicillium javanicum
eukaryotic initiation factor-2 alpha, Toxoplasma gondii: genbank ay518935
eukaryotic initiation factor-5B: a 175,000 kd factor; homologue of prokaryotic initiation factor-2; mediates joining of subunits
eukaryotic peptide initiation factor-1A: seems to be required for maximal rate of protein biosynthesis; may enhance ribosome dissociation into subunits and stabilize the binding of the initiator met-trna(i) to 40 s ribosomal subunits; refseq nm_010120 (mouse); nm_001412 (human)
eukaryotic release factor 1, Arabidopsis: has been sequenced; do not confuse with erf-1 protein, an ethylene response factor
eukaryotic release factor 1, S cerevisiae: results indicate that eukaryotic release factor 1 (erf1) is phosphorylated in vivo at serine 421 and serine 432 by the ck2 protein kinase in the budding yeast saccharomyces cerevisiae
eukaryotic translational regulator p97: 28% to two-thirds of the c-terminus of eif4g; amino acid ; genbank u73824
eumelanin: brown-black melanin pigment synthesized in mammals distinguished from the red-yellow phaeomelanin; found in brown-black hair and skin
eumenine mastoparan-AF: a mast cell degranulating peptide from the venom of the solitary wasp anterhynchium flavomarginatum micado, the most common eumenine wasp found in japan; emp-af 1-3 are three analogs; amino acid
eumiliin, Euphorbia milii: 30 kda protease with caseinolytic and fibrinogenolytic activities, but no hemorrhagic or defibrinating activities from the latex of euphorbia milii var. hislopii
eunicin: cyclic diterpenoid from gorgonians of the eunicea genus; rn given refers to (3as-(3ar*,5r*,6s*,9e,14s,15r,15as*))-isomer; rn for cpd without isomeric designation not avail 9/9
euodirutaecin A: from the coptidis rhizoma-euodiae fructus couple
euodirutaecin B: from the coptidis rhizoma-euodiae fructus couple
euojaposphingoside A: from the stem bark of euonymus japonicus thunb
euojaposphingoside B: from the stem bark of euonymus japonicus thunb
euojaposphingoside C: from the stem bark of euonymus japonicus thunb
euonymusisopimaric acid A: bioactive cpd from the stems of euonymus oblongifolius
euonymusisopimaric acid B: bioactive cpd from the stems of euonymus oblongifolius
euonymusisopimaric acid E: bioactive cpd from the stems of euonymus oblongifolius
eupacunin: antileukemic sesquiterpene lactone from eupatorium cuneifolium
eupaformosanin: inhibits deoxyribonucleic acid synthesis in ehrlich ascites cells; ; rn given refers to (3ar-(3ar*,4r*(e),6e,9r*,10z,11ar*))-isomer
eupahyssopin: from the chloroform extract of the plant eupatorium hyssopifolium
eupalinilide E: promotes the expansion of myelo-erythroid hematopoietic progenitors
eupalinin A: from eupatorium chinense l. induces autophagocytosis in human leukemia hl60 cells
eupalinolide O: from eupatorium lindleyanum dc., induces cell cycle arrest and apoptosis in human mda-mb-468 breast cancer cells
eupalitin 3-O-galactopyranoside: a flavonoid glycoside; from the plant boerhaavia repens
eupalitin 3-O-galactopyranosyl(1-2)-glucopyranoside: a flavonoid glycoside; from the plant boerhaavia repens
eupalmerin acetate: cyclic diterpenoid from gorgonians of the eunicea genus; rn given refers to (1ar-(1ar*,4e,9s*,10r*,13as*,14r*))-isomer; rn for cpd without isomeric designation not avail 9/93
eupaserrin: antileukemic sesquiterpene lactone from eupatorium semiserratum
eupatorin: a flavonoid from the east asian medicinal plant orthosiphon spicatus; prevents oxidative inactivation of 15-lipoxygenase
eupenicinicol A: from an endophytic fungus, eupenicillium sp. lg41
eupenicinicol B: from an endophytic fungus, eupenicillium sp. lg41
eupenicisirenin A: from an endophytic fungus, eupenicillium sp. lg41
eupenicisirenin B: from an endophytic fungus, eupenicillium sp. lg41
euphauserase: a brachyurin type digestive enzyme isolated from antarctic krill; amino acid
euphococcinine: defensive homotropane alkaloid found in blood of mexican bean beatle, epilachna varivestis
euphohelioscopin A: a pkc activator capable of inducing macrophage differentiation; from euphorbia helioscopia
euphoheliosnoid D: a jatrophone-type diterpenoid, was isolated from the chinese medicinal herb euphorbia helioscopia l.
euphoheliosnoid E: has antimicrobial activity; isolated from euphorbia helioscopia
euphomilone A: highly modified ent-rosane diterpenoid isolated from aerial parts of euphorbia milii
euphomilone B: highly modified ent-rosane diterpenoid isolated from aerial parts of euphorbia milii
euphorbia factor L1: reverses abcb1-mediated multidrug resistance; isolated from euphorbia; struture in first source
euphorbia factor L2: extracted from euphorbia lathyris l.; has antineoplastic properties
euphorbiasteroid: may reverse multidrug resistance; a phytogenic antineoplastic agent; isolated from euphorbia lathyris
euphorbin: isolated from latex of euphorbia milii, var. milii; induces neutrophil migration and aggregation
euphosantianane A: premyrsinane diterpenoid isolated from euphorbia sanctae-catharinae
euphosantianane D: premyrsinane diterpenoid isolated from euphorbia sanctae-catharinae
euphoscopoid A: has antifeedant activity; isolated from euphorbia helioscopia
euphoscopoid B: has both antineoplastic and antifeedant activities; isolated from euphorbia helioscopia
euphoscopoid C: has antifeedant activity; isolated from euphorbia helioscopia
euphosquamosin A: from euphorbia squamosa, a potent inhibitor of candida albicans multidrug transporters
euphosquamosin B: from euphorbia squamosa, a potent inhibitor of candida albicans multidrug transporters
euphosquamosin C: from euphorbia squamosa, a potent inhibitor of candida albicans multidrug transporters
euphowelwitschine A: antiproliferative from euphorbia welwits chii
euphowelwitschine B: antiproliferative from euphorbia welwits chii
eupolauridine: azafluoranthene from cleistopholis patens; ; rn from chem abst. index guide 1986
eupomatilone-3: represents a family of lignans from aastralian shrub eupomatia bennettii
eurifoloid A: tetracyclic diterpenoid with a bridged (5-7-7) tricyclic core
eurocidin C: isolated from streptoverticillium eurocidicum; mf c39-h59-n-o15
eurocidin D: ; isolated from streptoverticillium eurocidicum; mf c40-h61-n-o15
eurocidin E: ; isolated from streptoverticillium eurocidicum; mf c40-h61-n-o14
eurocrine L3: a heat-killed bacille calmette-guerin (h-kbcf) nasal vaccine
europhenol A: from a mangrove-derived fungus eurotium rubrum ma-150
europium DOTA-tetraglycinate: a europium(iii) biosensor
europium(II) stearate: confers resistance to oxidation to prosthetic articulating surfaces
europium(III) tetracycline: used as fluorescent probe, which is incorporated into a polyacrylonitrile-co-polyacrylamide polymer matrix
europium-thenoyltrifluoroacetone: used to the determination of total protein in human serum samples
europium-tris(dibenzoylmethane)-1,10-phenanthroline: a luminescent rare earth-contaning compound
eurothiocin A: an alpha-glucosidase inhibitor; isolated from eurotium rubrum
eurothiocin B: an alpha-glucosidase inhibitor; isolated from eurotium rubrum
euryacoumarin A: anti-inflammatory and antimicrobial from the stems of eurya chinensis
euryacoumarin B: anti-inflammatory and antimicrobial from the stems of eurya chinensis
eurycomanol: rn given for (1beta,2alpha,11beta,12alpha,15beta)-isomer; quassinoid isolated from eurycoma longifolia
eurycomanol 2-O-glucopyranoside: quassinoid isolated from eurycoma longifolia
eurycorymbic acid: from the stem of eurycorymbus cavaleriei (sapindaceae)
eurycorymboside A: from the stem of eurycorymbus cavaleriei (sapindaceae)
eurycorymboside B: from the stem of eurycorymbus cavaleriei (sapindaceae)
euryjanicin B: from the puerto rican marine sponge prosuberites laughlini
euryjanicin C: from the puerto rican marine sponge prosuberites laughlini
euryjanicin D: from the puerto rican marine sponge prosuberites laughlini
eurysterol A: cytotoxic and antifungal steroidal sulfate from a marine sponge of the genus euryspongia
eurysterol B: cytotoxic and antifungal steroidal sulfate from a marine sponge of the genus euryspongia
euscaphic acid: isolated from medicinal plant, euscaphis japonica pax.; structure; rn given refers to 2alpha,3alpha-isomer
eustomin: a methoxylated xanthone derivative; isolated from centaurium erythraea
eusynstyelamide: a modified dimer peptide; isolated from the ascidian eusynstyela misakiensis
eusynstyelamide A: nnos inhibitor from the ascidian eusynstyela latericius
eusynstyelamide B: nnos inhibitor from the ascidian eusynstyela latericius
eusynstyelamide C: nnos inhibitor from the ascidian eusynstyela latericius
eutirucallin protein, Euphorbia tirucalli: has proinflammatory activity
eutypellol A: from the marine sediment-derived fungus eutypella scoparia fs46
eutypellol B: from the marine sediment-derived fungus eutypella scoparia fs46
eutypellone A: from the endophytic fungus eutypella sp. bcc 13199.
eutypellone B: from the endophytic fungus eutypella sp. bcc 13199.
eutypine-reducing enzyme: nadph-dependent enzyme; amino acid ; genbank af033851
eve protein, Drosophila: encodes a product with specific rna polymerase ii transcription factor activity involved in neurogenesis; nucleotide sequence given in first source; composed of 376 amino acid residues; homologous protein found in other species
evinacumab: an angptl3-blocking antibody; fda approved for the treatment of homozygous familial hypercholesterolemia
eviprostat: combination of mn-ethamsylate & plant extracts used in therapy of prostatism
evl-20 protein, C elegans: encodes a functional homolog of human arl2. elimination of evl-20 function results in abnormal vulval, gonad, and male tail development and disrupts embryonic proliferation, hypodermal enclosure, and elongation; amino acid
evobrutinib: a selective oral btk inhibitor that has been shown to inhibit b-cell activation both in vitro and in vivo
evocalcet: a novel, oral, positive allosteric modulator of the calcium-sensing receptor for the treatment of shpt patients undergoing hemodialysis
evodiamine: from the fruit of evodia rutaecarpa bentham (rutaceae)
evolved beta-galactosidase, E coli: from e coli; used a a model for studying the details of acquisitive evolution via changes in the catalytic properties of enzymes & accompanying changes in the properties of regulatory elements; genbank m64441
evorubodinin: from the dried and nearly ripe fruits of euodia rutaecarpavar
evx1 protein, zebrafish: an even-skipped related gene displays during bony ray morphogenesis, a unique repetitive expression pattern along the proximodistal axis of the fin; has been sequenced
ex protein, Drosophila: amino acid sequence given in first source; important in the control of cell proliferation in imaginal discs; refseq nm_057492
exbD protein, E coli: from e coli; contains 141-amino acid residues; found in cytoplamic membrane; homologous to tolr protein; required to complement exb mutations; amino acid sequence given in first source
exc-5 protein, C elegans: required for development of the excretory cells; genbank ab060647; refseq nm_001027868.3
excavatoid P: isolated from the octocoral briareum excavatum; structure in first sour
excavatolide B: isolated from marine soft coral (briareum excavatum); effectively inhibits tpa-induced vascular permeability in mouse skin
excelsione: a depsidone from an endophytic fungus isolated from the new zealand endemic tree knightia excelsa
exchanger inhibitory peptide: amino acid sequence given in first source; potently inhibits na+-ca2+ exchange activity
excisanin A: isolated from leaves and stems of radbosia serra (maxim) hara
excisanin H: cytotoxic 14,20-epoxy-ent-kaurene diterpenoid from rabdosia excisa
excisionase: acidic protein containing 66 amino acids; the xis gene is transcribed away form the viral attachment site; involved in site-specific recombination of bacteriophages; amino acid sequence known
excisusin F: inhibits nitric oxide production; isolated from isodon excisus
excitability-inducing molecule: high mol wt polymeric protein, channel forming ionophore which can induce action potential in lipid bilayers & lyse red blood cells
excitatory peptide 2, Achatina: isolated from the african giant snail achatina fulica; a myoactive tetradecapeptide; amino acid sequence given in first source
excitatory peptide 3, Achatina: a myoactive tetradecapeptide isolated from the african giant snail achatina fulica; amino acid sequence given in first source
excitatory peptide 4, Fusinus: a myoactive tetradecapeptide isolated from the african giant snail fusinus ferrugineus; amino acid sequence given in first source
excocarinol A: has antineoplastic activity; isolated from excoecaria acerifolia
excoecarin F: isolated from the chinese ethnodrug gua-jing-ban (excoecaria acerifolia didr.)
excoecarin G: isolated from the chinese ethnodrug gua-jing-ban (excoecaria acerifolia didr.)
excoecarin H: isolated from the chinese ethnodrug gua-jing-ban (excoecaria acerifolia didr.)
excoecarin R1: bis-secolabdane diterpenoid from the resinous wood of excoecaria agallocha; sructure in first source
excoecarin R2: bis-secolabdane diterpenoid from the resinous wood of excoecaria agallocha; sructure in first source
excoecarioside A: from excoecaria cochinchinensis (euphorbiaceae)
excoecarioside B: from excoecaria cochinchinensis (euphorbiaceae)
excretory-secretory antigen, Trichinella: a 53 kda immunodominant antigen from t. spiralis; amino acid sequence given in first source; genbank u25127
excretory-secretory protein 1, Ancylostoma ceylanicum: isolated from the hookworm ancylostoma ceylanicum; genbank ay046590
excretory-secretory protein 11 kDa, Trichostrongylus colubriformis: capable of protecting guinea pigs against the parasite, partial base and amino acid sequence data available in first source; rn given refers to trichostrongylus colubriformis clone pbta503
excretory-secretory protein, Ostertagia: from the larvae of opisthorchis; amino acid ; genbank z46800
exd protein, Drosophila: a regulator of homeotic gene activity, expressed during embryogenesis; drosophila homolog of human proto-oncoprotein pbx1 (71% identity); 376 aa residues, mw 41.7 kda; amino acid ; refseq nm_078636
exeE protein, Aeromonas hydrophila: amino acid sequence given in first source; for extracellular export and outer membrane biogenesis in aeromonas hydrophila
exeF protein, Aeromonas hydrophila: general secretion pathway protein f; involved in general secretion pathway for the export o f proteins; has been sequenced; isolated from aeromonas hydrophila; an integral membrane protein with multiple transmembrane domains
exebacase: a potent antistaphylococcal lysin originally isolated from streptococcus phage
exendin (5-39): a glucagon-like peptide-1 receptor antagonist
exendin (9-39): a peptide from the venom of the lizard heloderma suspectum; inhibits glucagon-like peptide-1 (glp-1) induced camp production; its structure is related to exendin-4
exendin 3: from the gila monster lizard (heloderma horridum); amino acid sequence given in first source
exex protein, Drosophila: important transcription factor in the regulation of hematopoiesis
exiguamine B: inhibits indoleamine-2,3-dioxygenase; isolated from neopeetrosia exigua
exiguaquinol: a pentacyclic hydroquinone from neopetrosia exigua that inhibits helicobacter pylori muri
exiguolide: a 16-membered macrolide isolated from the marine sponge geodia exigua thiele
eximisoside A: a triterpene glycoside from the far-eastern sea cucumber psolus eximius
exo protein, Bacteriophage lambda: processively degrades one strand of double-stranded dna in the 5"-3" direction
exo-1,3-alpha-glucanase: for mutanase consider also ec 3.2.1.59, endo-1,3-alpha-glucanase
exo-1,4-beta-D-xylosidase: genbank ab022788 (xysb protein)
exo-1,4-beta-galactanase: from bacillus subtilis; hydrolyzes soybean arabinogalactan to yield galactobiose & small amounts of galactotetrose
exo-1,4-beta-mannanase: from aeromonas hydrophila subsp. anaerogenes
exo-1,6-alpha-glucosidase: hydrolysis of (1->6)-alpha-d-glucosidic linkages in 1->6-alpha-d- glucans and derived oligosaccharides; found mainly in streptococcus equisimilis, mutans, and pneumonia as well as in mycoplasma pulmonis
exo-3,6-endo-epoxy-4,5-epoxyhexahydrophthalic anhydride: blocks free protein amino groups
exo-alpha-L-arabinanase: catalyzes hydrolysis at the nonreducing terminus of alpha-1,5-l-arabinan to release arabinobiose
exo-beta-(1--3)-D-galactanase: from irpex lacteus (polyporus tulipferae); hydrolyzes specifically oligosaccharides & polymers of (1--3)-linked beta-d-galactopyranosyl residues; maximal activity exhibited at ph 4.6
exo-beta-D-galactofuranosidase: catalyzes release of galactose from methyl & ethyl-beta-d-galactofuranosides, from 6-o-beta-galactofuranosyl-d-galactose & 5-o-beta-galactofuranosyl-containing peptidophosphogalactomannan from p. charlesii culture filtrates
exo-beta-D-glucosaminidase: capable of hydrolyzing chitobiose; from culture filtrate of nocardia orientalis ifo 12806; exo-hydrolase, removing single glucosamine residues from the nonreducing terminal of a sequence of beta-(1--4)-linked glucosamine chain, such as chitosan & chitooligosaccharides; does not act on acetylated substrates or aryl-beta-glycosides
exo-poly-alpha-galacturonosidase: catalyzes the hydrolysis of pectic acid from the non-reducing end releasing digalacturonate
exoATPase: hydrolyzes extracellular atp; aspect of ec 3.6.1.3
exoN protein, human: a 3'-5' exonuclease that cleaves 1-arabinofuranosylcytosine monophosphate and 9-arabinofuranosyl-2-fluoroadenine 5'-monophosphate from the 3' end of dna; may function as a proofreader for the exonuclease-deficient replicative dna pol alpha
exoZ protein, Rhizobium meliloti: from rhizobium meliloti; involved in production of acidic exopolysaccharides; 23% identical to rhizobium leguminosarum nodx protein; amino acid sequence given in first source
exoc5 protein, zebrafish: an exocyst protein; refseq nm_001113796
exochelins: functional extracellular iron-binding agent; water-soluble iron-binding cpds from mycobacteria; major component a cyclic hexapeptide containing 3 mol of epsilon n-acetyl-epsilon-n-hydroxylysine
exocrine-gland-secreting peptide 1, mouse: secreted into tear fluid and detected by the vomeronasal organ; genbank ab194091
exocrine-gland-secreting peptide 36, mouse: secreted into tear fluid and detected by the vomeronasal organ; genbank ab307016
exocyst complex component sec3A, Arabidopsis: refseq nm_001198234
exocytosis coupled protein, rat: cholinergic stimulation of the parotid gland is associated with a membrane-bound phosphorylated protein i named ec-protein from rat
exodeoxyribonuclease I: exonucleolytic cleavage in the 3' to 5' direction to yield 5'-phosphomononucleotides; preference for single-stranded dna; e.coli enzyme hydrolyzes glucosylated dna
exodeoxyribonuclease II: exonucleolytic cleavage in 5' to 3' direction to yield 5'-phosphomononucleotides; degrades only single-stranded dna
exodeoxyribonuclease VII: exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides; preference for single-stranded dna
exoenzyme C3, Clostridium botulinum: cethrin and ba-120 are both a recombinant variant of c3 transferase with neuroprotectant activity; adp-ribosylates specific g proteins
exoenzyme S: a bifunctional type-iii secreted cytotoxin; has gtpase-activating (gap) and p-ribosyltransferase (adprt) functional domains
exogastrula-inducing peptide A, Anthocidaris crassispina: 52 amino acid residues given in first source; intrinsic factor that affects the development of sea urchin embryos; may have important role in normal development to induce gastrullation; related to epidermal growth factor
exogastrula-inducing peptide C, Anthocidaris crassispina: 58 amino acid residues given in first source; intrinsic factor that affects the development of sea urchin embryos; may have important role in normal development to induce gastrullation; related to epidermal growth factor
exogastrula-inducing peptide D, Anthocidaris crassispina: 53 amino acid residues given in first source; intrinsic factor that affects the development of sea urchin embryos; may have important role in normal development to induce gastrulation; related to epidermal growth factor
exon 3-deleted preproghrelin, human: encodes mature ghrelin plus a novel c-terminal peptide; has been sequenced
exonuclease Bal 31: recognizes & cleaves salt-induced conformational junction left-handed z-dna & right-handed b-dna; also has some exonuclease activity; contains exonuclease activity for dna with single or double stranded ends
exonuclease IX, E coli: has 3'-5' exonuclease and phosphodiesterase activities; acts on single-stranded dna
exonuclease, Aspergillus: degrades dna and rna by exonucleolytic 3'--> 5' cleavage to produce 5'-mononucleotides; has intrinsic nicking activity; acts on circular double-stranded dna and native dna and rna; isolated from aspergillus
exophthalmos producing substance: minor descriptor (65-72); major descriptor (73-85); on-line search thyrotropin (66-85); index medicus search exophthalmos producing substance (73-85)
exopisiod B: from the antarctic-derived fungus penicillium sp. hdn14-431
exopolysaccharide B39: isolated from lactococcus lactis; carbohydrate
exopolysaccharide V2-7, Halomonas: isolated from halomonas eurihalina
exopolysaccharide biopolymer, Bacillus coagulans: an antioxidant carbohydrate biopolymer from the probiotic bacterium rk-02
exopolysaccharide, Bacillus: from bacillus mucilaginosus
exopolysaccharide, Pseudomonas: acid exopolysaccharide from pseudomonas marginalis consisting of a repeating unit of ->4)-beta-d-manp-(1->3)alpha-d-glcp-(1->4)alpha-l-rhap-(1-
exopolysaccharide, Streptococcus: exopolysaccharide from streptococcus thermophilus consisting of the tetrasaccharide repeating unit ->3)-beta-d-galp(1->3)-(alpha-d-galp(1->6))-beta-d-glcp(1->3)-alpha-d-galpnac(1->
exordium protein, Arabidopsis: may be involved in regulating cell division; amino acid
exoribonuclease H: rnase h iii is probably proteolytic cleavage product of rnase h i & is 30,000 mw enzyme that lacks dna polymerase activity; random exonuclease with unusual ability to generate large as well as small oligonucleotide products
exoribonuclease II: formerly ec 3.1.4.20; see also ec 3.1.27.1 for an endoribonuclease ii
exoribonuclease T: initiates attack at 3' hydroxyl terminus of trna releasing amp in random mode of hydrolysis; optimally active at ph 8-9; requires divalent cation
exosterol: combination of dexamethasone pivalate & phenyl mercury borate in external therapy of skin diseases
exotine A: from roots of murraya exotica; showed inhibition of nitric oxide production in lipopolysaccharide-induced bv-2 microglial cells
exotine B: from roots of murraya exotica; showed inhibition of nitric oxide production in lipopolysaccharide-induced bv-2 microglial cells
exp protein, Drosophila: regulates the receptor tyrosine kinase pathway to control tracheal tube size; refseq nm_165853
exp-2 protein, C elegans: a voltage-gated potassium channel; amino acid ; do not confuse with exp-2 protein
expI protein, Erwinia: an autoinducer synthesis protein which binds to expr and thus responsible for the global control of virulence & exoenzyme production in the plant pathogen erwinia carotovora & erwinia chrysanthemi; required for the production of n-(3-oxohexanoyl)-homoserine lactone (ohhl); amino acid sequence given in first source
expansin protein, plant: mediates cell wall expansion in plants; amino acid sequence given in first source; genbank z37585 (atex1)
expansol A: from the marine-derived fungus penicillium expansum; structure in first souce
expansol B: from the marine-derived fungus penicillium expansum; structure in first souce
exrheudon-dragees: combination of the above; differs from exrheudon-salbe
extensin protein, plant: plant cell wall insoluble hydroxyproline-rich glycoprotein (hrgp); amino acid sequence has been determined
extra parotid glycoprotein, human: human salivary 19-20 kda glycoprotein; present mainly in submandibular-sublingual saliva; a potential enamel pellicle component; has been isolated and characterized; 13% carbohydrate content; molar ratio of fuc:man:gal:glcnac:neuac = 3.4:2.6:2.9:4.0:0.4
extracellular basic protease, Dichelobacter nodosus: isolated from culture supernatants of several different serogroups of virulent d nodosus strains; synthesized as a precursor molecule; amino acid sequence of native protease given in first source; genbank z16080
extracellular carboxyl proteinase, Candida pulcherrima: has a broad substrate specificity for a variety of proteins, hydrolyzes casein, bsa, hemoglobin, keratin & collagen; enzyme activity completely abolished by pepstatin a; mw 36.5 kda
extracellular leucine-rich repeat fibronectin containing 1 protein, mouse: refseq nm_175522
extracellular polysaccharide 6: isolated from erwinia chrysanthemi; carbohydrate
extracellular slime proteins, bacterial: found in exopolysaccharide slime of pseudomonas aeruginosa and other bacteria; elicits same toxic, leukopenic, & lethal manifestations that have been observed after lethal infection of mice by viable bacteria; also acts as protective antigen in active & passive immunization in mice challenged by viable cells
extradiol dioxygenase: involved in degradation of aromatic compounds such as cresol and protocatechuate
extralife: a flavonoid- and tannin-rich extract of pentaphylloides fruticos
extrasporogenous cells protein, Arabidopsis: a leucine-reich repeat (lrr) receptor kinase; ragulates male germline cell number and tapetal identity and promotes seed development
exu protein, Drosophila: amino acid sequence given in first source; required for establishment of bcd mrna localization in developing oocyte of drosophila melanogaster
ey protein, Drosophila: isolated from drosophila; amino acid ; see also pax6 protein; refseq nm_079889
eya protein, Drosophila: required for development of eye progenitor cells in drosophila; has been sequenced; do not confuse with clusterin, which is also known as cli gene product; refseq nm_164693
eye2 protein, Chlamydomonas reinhardtii: eye2 gene required for eyespot assembly in chlamydomonas reinhardtii; genbank af233430
eyg protein, Drosophila: is required for eye development and appears to act cooperatively with eyeless protein; refseq nm_079318
eys protein, Drosophila: refseq nm_001032399.1;np_001027571.1; genbank dq991915
ezrin: homologous chicken microvillar core protein mw 81k; protein is a protein-tyrosine kinase substrate
f protein, Agrobacterium tumefaciens: in contrast to gene product e, f protein seems not to be essential for tumour formation; amino acid sequence given in first source; genbank z29717
fabclavine Ia: has both antibacterial and antifungal activities; isolated from faber clavorum
faceles pollen-1 protein, Arabidopsis: may be involved in biosynthesis of tyrphine, sporopollenin of exine and wax of stems and siliques; genbank ab099512
factor AF2: extract from spleen & liver of lamb & sheep embryos; contains peptides, glycopeptides, glycolipids, and nucleotides; used as supportive agent during chemotherapy
factor C, Streptomyces: an extracellular signal protein involved in morphological differentiation of streptomyces griseus; mw 32 kda; amino acid
factor D (liver): a putative poly(thymidine) template stimulatory protein of dna polymerases; mw 58kda
factor EF-P: a nonribosomal (soluble) protein of e coli that stimulates peptide bond synthesis with certain aminoacyl-trna analogs
factor H receptors: see also bacterial protein: factor h-binding protein, neisseria meningitidis
factor H-related protein 1: from plasma; n-terminal amino acid sequence given in first source
factor H-related protein 2: from plasma; n-terminal amino acid sequence given in first source
factor II clotting antigen: with pivka-ii comprises active prothrombin and inactive precursor prothrombin
factor IX (1-47): contains 12 residues of l-gamma-carboxyglutamic acid
factor IX BM Hilo: arg replaced by gln in position 180; has been sequenced
factor IX BM Lake Elsinore: ala replaced by val at postion 390; indistinguishable from normal ixa in its activity toward a small synthetic substrate
factor IX BM Nagoya: arg replaced by trp at position 180; natural mutant of factor ix responsible for severe hemophilia b
factor IX Basel: the gene for factor ix contains a single base mutation of a t-c transition at nucleotide 10418
factor IX Cambridge: a mutant factor ix isolated from a patient with hemophilia b; homologous to factor ix except for an 18-residue propeptide extension on the nh2 terminus
factor IX Chapel Hill: histidine replaces arginine at position 145; factor ix in hemophilia b chapel hill has reduced activity relative to normal with only one of two peptide bonds hydrolyzed during activation
factor IX Chongqing: abnormal factor ix; glu replaced to val in position 27; results in severe hemophilia b
factor IX Deventer: hemophilia bm variant; mutation in the arg 180-val bond
factor IX Fc fusion protein: consists of factor ix fused to the fc fragment of human igg1
factor IX Kawachinagano: retains propeptide region of 18 amino acids due to a substitution of arg by glu at position 4; activation of mutant factor by factor xia in the presence of ca ions is defective; causes severe hemophilia b & no detectable clotting activity
factor IX Leyden: causes hemophilia b; g replaced by a at nucleotide -6 of the factor ix gene
factor IX Long Beach: ile replaced by thr at position 397 of the zymogen; genetic defect responsible for a dysfunctional protein
factor IX Nagoya 3: arg replaced by his at position 145; natural mutant of factor ix responsible for severe hemophilia b
factor IX Niigata: mutant factor ix responsible for moderately severe hemophilia b; ala replaced by val at position 390
factor IX San Dimas: substitution of glu for arg at position 4 in the propeptide leads to incomplete gamma-carboxylation & altered phospholipid binding properties
factor IX Seattle(2): abnormal factor ix; single adenine nucleotide in exon v deleted; therefore valine replaces aspartic acid in position 85 with the formation of a stop signal at position 86
factor IX Strasbourg 2: a mutation, gly replaced by ala at position 6365 leads to the substitution of gln for arg at position -4 of the propeptide; associated with severe form of hemophilia b
factor IX Troed-y-Rhiw: substitution of glu for arg at position 4 of the propeptide which blocks cleavage between arg145-ala146 in the activator peptide and leads to circulation of the mutant factor with the propeptide still attached; abolishes haeiii restriction enzyme recognition & impairs calcium binding
factor IX Zutphen: a variant factor ix molecule with arg replacing cys(18); isolated from the blood of a patient with severe haemophilia b
factor IX-binding protein, Trimeresurus flavoviridis: consists of alpha- and beta-chains; the beta-chain is identical to that of ix-x-bp; isolated from trimeresurus flavoviridis; genbank d84451
factor IX-factor X-binding protein, Crotalinae: from trimeresurus flavoviridis and other crotalid venoms; amino acid sequence given in first source; rn given is for a-chain
factor IX-factor X-binding protein, Echis carinatus: binds gpib; isolated from the venom of echis carinatus leucogaster; amino acid
factor V Leiden: arg replaced by gln at position 506; this mutation does not result in factor v deficiency, instead it gives activated protein c resistance
factor V Stanford: mutation caused by a 4 base insertion at nt 2856, results in a frameshift with loss of a thrombin activation site
factor V activating enzyme: a coagulant protein from vipera lebetina snake venom; amino acid
factor V clotting antigen: factor v:ag designates factor v antigen; factor v:c designates factor v clotting activity
factor VIII Ise: an abnormal factor viii with a missense mutation at arg(2159) to cys which modifies the antigenicity of the c2 domain
factor VIII delta II: genetically engineered antihaemophilic factor variant expressed by recombinant chinese hamster ovary cells, in which a major portion of the central (b) domain & part of the light chain (pro771-asp1666) are missing
factor VIII, von Willebrand factor drug combination: a plasma-derived dual fviii/vwf concentrate
factor VIII-Fc fusion protein: consists of factor viii fused to the fc domain of igg1; for treatment of hemophilia a
factor VIII-von Willebrand factor concentrate 8Y: suitable and haemostatically effective for continuous infusion treatment in patients with vwd
factor X Kanazawa: a heterozygote for a g to a substitution in exon 5 of the factor x gene of the proband; this mutation predicts an amino acid replacement of arginine (arg) for glycine (gly) at codon 114 in the second egf-like domain
factor X Padua: arginine replaces tryptophan at position 251; mutation affects activation via the extrinsic pathway
factor X St. Louis II: glycine replaces gamma-carboxylated glutamic acid at position 7
factor X Wenatchee II: factor x variant with asn-57 replaced by thr
factor X activator, Bothrops atrox venom: from venom of bothrops atrox; mw 59,000 & either one or two light chains forming a doublet of 14,000 to 15,000; act specifically to activate factor x; cleaves heavy chain of factor x to yield activatied factor xaalpha & cleavage near the n-terminal end of the heavy chain generating factor xmu and cleavage located at one extremity of the heavy chain of factor xaalpha generating xa(nu)
factor X-binding protein, Deinagkistrodon acutus: isolated from the venom of deinagkistrodon acutus; amino acid
factor XII Locarno: abnormal factor xii; affects the plasma kallikrein cleavage site arg 353-val 354, & therefore the formation of activated factor xii
factor XII Mie-1, human: mutation fxii mie-1 (introduction of cys486) results in the reduced secretion of fxii protein in a japanese family; a homozygous substitution of g to c at 10587 (cdna position 1458) in the fxii gene results in a trp to cys substitution in the catalytic domain; reduced secretion of fxii protein was due to incorrect folding caused by the introduction of cys486
factor XII Toronto: abnormal nonfunctional factor xii; purified from a cross-reactin material positive hageman (factor xii) trait plasma
factor XII Washington D.C.: congenital abnormal coagulation factor xii; cys replaced by ser at position 571
factor XIII activation peptide: a 37-aminoacyl n-terminal peptide cleaved from the a subunit of factor xiii, this reaction is catalyzed by alpha-thrombin
factor XIIa inhibitor: glycoprotein from plasma with mw 85kda reduced & 92kda non-reduced
factor Xa, Glu-Gly-Arg-: a competitive inhibitor of factor xa
factor inhibiting hypoxia-inducible factor 1, mouse: has asparaginyl hydroxylase activity; refseq nm_176958
factor rXai: recombinant factor xa with two point mutations (asn322ala419); a prothrombinase complex antagonist
fad3 protein, Arabidopsis: an omega-3 desaturase; has high homology to fad7 protein, arabidopsis; see also: omega-3 fatty acid desaturase
fadE5 protein, Mycobacterium tuberculosis: genbank al123456.3
fadL protein, E coli: amino acid sequence has been determined; central component of the long chain fatty acid transport system in e coli; involved in translocation of long-chain fatty acids across the outer membrane; genbank m60607
faeE protein, E coli: from e coli; involved in biosynthesis of k88 fimbriae; chaperone-like protein; amino acid sequence given in first source; genbank z11699
faeriefungin: isol from streptomyces griseus; a polyol polyene macrolide lactone antibiotic; ; a mixture of faeriefungin a and faeriefungin b; similar to mycoticin and flavofungin but has different physiochem & biol properties
faeriefungin A: isolated from streptomyces griseus; ; component of faeriefungin - see also record for faeriefungin
faeriefungin B: isolated from streptomyces griseus; ;component of faeriefungin; see also record for faeriefungin
falcarindiol: from leaves of schefflera digitata (araliaceae) and in carrots; inhibits germination of spores of most common dermatophyte fungi
falcarinol: an acetylenic hydrocarbon, similar to cicutoxin, derived from oleic acid in araliaceae, umbelliferae and other plants; rn given refers to (r-(z))-isomer; it can cause contact dermatitis in some individuals; panaxynol is the 3,4-cis-8,9-trans isomer of falcarinol
falcilysin protein, Plasmodium falciparum: involved in hemoglobin catabolism; isolated from plasmodium falciparum; genbank af123458
falcipain: a plasmodium falciparum trophozoite cysteine proteinase that degrades hemoglobin; a target for antimalarial chemotherapy
falcipain 2: isolated from plasmodium falciparum; amino acid ; genbank af239801
falcipain 3: a trophozoite-specific enzyme localized in the food vacuole; genbank af282974
falintolol: rn & ; rn refers to (anti-(r))-isomer
falipamil: bradycardic agent which blocks myocardial calcium channels in frequency- & voltage-dependent manner; rn given refers to parent cpd; structure given in unlisted drugs
fallaxidin 4.1, Litoria fallax: a moderately active antibiotic fallaxidin from the skin secretion of the eastern dwarf tree frog litoria fallax
fallaxin, Leptodactylus fallax: a 25-mer antibacterial peptide amide from the west indian mountain chicken frog leptodactylus fallax; inhibits growth of several gram-negative bacteria including enterobacter cloacae, escherichia coli, klebsiella pneumoniae, and pseudomonas aeruginosa; amino acid
falp protein, mouse: a fat tissue-specific low molecular weight protein that responds to insulin; preferentially expressed in adipocytes but not in preadipocytes & strictly localizes at a compact perinuclear membrane compartment; refseq nm_029844
falstatin, Plasmodium falciparum: a cysteine protease inhibitor that facilitates erythrocyte invasion; genbank dq288863
familial Alzheimer's disease protein 1: expressed in lymphoblastoid & brain cells derived from alzheimer's disease patients; amino acid sequence given in first source; genbank x81004
famprofazone: ; ingredient of gewodin; methamphetamine is a metabolite of this cpd
fanE protein, E coli: from e coli; involved in biosynthesis of k99 fimbriae; chaperone-like protein; amino acid sequence given in first source; genbank caa39474
fanasil, pyrimethamine drug combination: combination drug containing fanasil & pyrimethamine
fangchinoline: rn given refers to parent cpd; limacine is the (1'beta)-isomer; 7-o-demethyltetrandrine is the (1s,1's)-isomer
fantac: a mixture of n-acetyl thiazolidine carboxylic acid (n-atca) and folic acid; a biostimulant
fap1 protein, Streptococcus: a fimbriae-associated protein, involved in fimbriae assembly and adhesion of streptococcus parasanguis; has been sequenced
farA protein, Streptomyces: fara isolated from streptomyces; amino acid ; genbank ab001683
faradiol: ; rn refers to (3beta,16beta,18alpha,19alpha)-isomer
farbasol: the following constitute about 95% of farbasol: ethyltoluene, propylbenzene, isopropylbenzene, mesitylene, hemimelitene, psuedocumene, diethylbenzene, & cymene
fargesin-4-O-glucopyranoside: an antifungal agent isolated from styrax japonica
farglitazar: a non-thiazolidinedione insulin sensitiser and ppargamma agonist
faringel: used to treat heartburn; consists of alginate, sodium bicarbonate, honey, chamomille, aloe vera, and propolis gel
farinomalein: a maleimide-bearing compound from the entomopathogenic fungus paecilomyces farinosus
farinosone A: neurotrophic alkaloidal metabolite from the entomogenous deuteromycete paecilomyces farinosus
farinosone B: neurotrophic alkaloidal metabolite from the entomogenous deuteromycete paecilomyces farinosus
farinosone C: neurotrophic alkaloidal metabolite from the entomogenous deuteromycete paecilomyces farinosus
farletuzumab: a fully humanized mab that recognizes folate receptor alpha; may be useful in treating ovarian cancer; in phase ii clinical trials
farnan-2-one-3 beta-ol: from the stem bark of mimusops elengi
farnesal hydratase: converts farnesol to farnesal and 3-hydroxy-2,3-dihydrofarnesal
farneside A: from a marine-derived streptomyces sp., strain cnt-372 from fiji; has modest antimalarial activity against the plasmodium falciparum
farneside B: from a marine-derived streptomyces sp., strain cnt-372 from fiji
farnesoid X receptor-like orphan receptor, Xenopus: amino acid ; genbank af456451 (for1); af456452 (for2)
farnesoid X-activated receptor: an orphan nuclear receptor; activated by farnesol metabolites
farnesyl pyrophosphatase: catalyzes conversion of farnesyl pyrophosphate to pyrophosphate and farnesol
farnesyl pyrophosphate: a sesquiterpene that dimerizes to squalene; rn given refers to cpd without isomeric designation
farnesylacetone: c18 terpene; rn given refers to cpd without isomeric designation
farnesylacetone epoxide: extract from brown alga, cystophora moniliformis; c18 terpene
farnesylgeranyl diphosphate synthase: a prenyltransferase which synthesizes c25-prenyl diphosphate; distinct from geranylgeranyl diphosphate synthase (ec 2.5.1.29); can use geranylgeranyl diphosphate as a substrate
farnesylhydroquinone: from a marine-derived fungus penicillium sp.
farnesylleucyl-alanyl-arginyl-tyrosyl-lysyl-cysteine: methyl-accepting substrate to characterize a rat liver protein carboxyl methyltransferase
farnesylpyrophosphate cyclase: converts farnesylpyrophosphate to pentalenene; consider also trichodiene synthetase
farnesylthiotriazole: a neutrophil agonist; activates protein kinase c
farrerol 4'-O-beta-D-glucopyranoside: from the aerial parts of diplomorpha canescens
farrerol 7-O-beta-D-apiofuranosyl(1-6)-beta-D-glucopyranoside: flavanone glycoside from miconia trailii (melastomataceae)
farylhydrazone C: from the antarctic-derived fungus penicillium sp. hdn14-431