NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
immune system released activating agent, mouse: an immunologic factor; after parasitic challenge in experimental african trypanosomiasis, a dramatic expression of a novel gene, israa, in the spleen together with uppregualtion of its encoding protein was depicted
immunoRNase scFv 4D5-dibarnase: an antineoplastic agent
immunocorticotropin: corresponds to the sequence 11-20 of the variable part of the human immunoglobulin g1 heavy chain
immunodominant R16 protein, rat: amino acid sequence given in first source; an immunodominant determinant of irbp
immunodominant membrane protein A, phytoplasma: a 32 kda immunodominant membrane protein from the western x-disease phytoplasma; genbank af225904
immunoenhancing factor: cell-free soluble factor released from human allogeneic cell lines which is capable of augumenting an in vitro immune response of murine lymphocytes against heterologous erythrocytes; inactivated by heat or protease; mw 38,000
immunoglobulin A, immunoglobulin G, immunoglobulin M drug combination: polish product; combination of immunoglobulins a, g and m
immunoglobulin A-sepharose 4B: used in method for determination & removal of circulating immune complexes in pathological sera
immunoglobulin Fv: recombinant fragment of myeloma protein mcpc603 antibody variable region; information on amino-terminal protein sequence given in first source
immunoglobulin G (285-292): a fragment of human immunoglobulin g; 6 different sequences given with varying amino acid at position 285; rn refers to trp(285); amino acid sequence given in first source
immunoglobulin G-binding protein, Streptococcus suis type 2: n-terminal amino acid sequence given in first source; the 52 kda protein was later shown to be 60 kda
immunoglobulin lambda-like polypeptide 1, mouse: an immunoglobulin variable region-like peptide that is a component of surrogate light chain which associates with mu ig heavy chain to form pre b cell receptor
immunoglobulin light chain protein Sm lambda: isolated from urine of patient with a plasma cell dyscrasia resembling gamma-heavy-chain disease; mw 15,000; has substantial amounts of carbohydrates
immunoglobulin zeta, zebrafish: an isotype from the immunoglobulin heavy-chain locus in zebrafish; genbank ay643750
immunoglobulin-MBP3 protein, chimeric: ig acts as a vehicle for peptide delivery
immunoglobulin-binding factors: factor in supernatant of alloantigen-activated t cells which reversibly binds to igg, interfering with igg complement activation; also suppresses iga synthesis by t cell hybridomas; suppresses polyclonal human ige response; can also enhance ige synthesis; also a serine protease; see also record for mac-2 antigen (ige-binding protein)
immunoglobulins, Fd: major descriptor (73-86); minor descriptor (84-86); on-line search immunoglobulin fragments (73-86); index medicus search immunoglobulins, fd (73-86); immunoglobulin fragments (84-86)
immunophilin ligand 506BD: nonnatural immunophilin ligand which contains only the common structural elements of fk 506 & rapamycin; a high affinity ligand of fk 506-binding protein & potent inhibitor of fkbp rotamase activity; does not interfere with t cell activation, but blocks suppressive effects of fk 506 & rapamycin
immunorphin: corresponds to the sequence 364-373 of the ch3 domain of the human immunoglobulin g heavy chain and displays a 43% identity with the antigenic determinant of beta-endorphin
immunosuppressant protein p36, Dermacentor andersoni: amino acid ; genbank af167171
immunosuppressive 40 kDa protein, rat: induced by orthotopic liver transplantation in rats; n-terminal amino acid sequence given in first source
immunosuppressive acidic protein: high levels found in plasma of patients with cervical and/or ovarian neoplasms
immunosuppressive factor-neutral protein, mouse: endogenous immunosuppressive factor from liver; induced dose-dependent alternative changes in thymocyte viability
immunotoxin 4D5MOCB-ETA: the immunotoxin 4d5mocb-eta was developed by genetically fusing a truncated form of pseudomonas aeruginosa exotoxin a (eta) (eta(252-608)kdel) to the highly stable humanized single-chain antibody fragment (scfv) 4d5mocb; has potent and selective antitumor activity
immunotoxin HA22: a second-generation pseudomonas exotoxin a-based immunotherapy targeting cd22-expressing hematologic malignancies
immunotoxin LMB-7: a single-chain immunotoxin constructed from the murine monoclonal antibody b3 & a truncated form of pseudomonas exotoxin pe38
impA protein, Salmonella typhimurium: impa' protein and encoded on plasmid inci1 tp110; amino acid sequence given in first source; homologous to lexa and umud proteins; involved in uv protection and mutation
imperatorin: tumor necrosis factor antagonist; furanocoumarin from west african medicinal plant clausena anisata; structure in negwer, 5th ed, #3005
imperatoxin A: a 33-amino acid peptide from the venom of pandinus imperator which activates ca2+ release channels/ryanodine receptors; amino acid sequence given in first source
imperatoxin I: ryanodine receptor inhibitor; isolated from pandinus imperator; amino acid ; do not confuse with imperatoxin a
implitapide: a microsomal triglyceride transfer protein (mtp) inhibitor
import intermediate associated protein 100: isolated from chloroplasts of peas; amino acid ; genbank u56419
importin 9, rat: expressed throughout adult rat tissues; refseq mrna sequence xm_222661, xp_222661
imposit: combination of gramicidin, cetylpyridinium chloride, p-aminobenzoic acid & 2,4-dichlorobenzyl alcohol used therapeutically for inflammatory disease of mouth & pharynx
improsan: synonyms nsc-102627, alkylating agent 864 & yoshi 864 refer to hcl; rn given refers to parent cpd
imudon: polyvalent antigen complex of lyophilized lysates of lactobacillus, micrococcus, corynebacterium, fusiformus, klebsiella pneumoniae, candida albicans & merthiolate
in protein, Drosophila: a tissue polarity gene product from drosophila; amino acid ; refseq nm_176370
inaA protein, Pantoea ananatis: amino acid sequence given in first source; ice nucleation protein from erwinia ananas; enables bacteria to nucleate in supercooled water; genbank x17316
inaD protein, Drosophila: inad - inactivation no afterpotential d mutation; a photoreceptor-specific polypeptide; has 674 amino acid residues; involved in drosophila visual transduction; amino acid sequence given in first source
inaU protein, Pantoea ananas: an ice nucleation activity gene product; isolated from erwinia uredovora; amino acid ; genbank d14992
incarvilleatone: from incarvillea younghusbandii, inhibits nitric oxide (no) release
incensole acetate: a neuroprotectant from resin of boswellia carterii
inchinko-to: consists of artemisia capillari spica (artemisia), gardenia fructus (gardenia), rhei rhizoma (rheum); contains emodin, geniposide, capillarisin, dimethylesculetin & other compounds; used to promote bile secretion; has anti-jaundice properties
incilarin A, Incilaria fruhstorferi: c-type lectin isolated from body surface mucus of the land slug incilaria fruhstorferi; amino acid ; genbank ab003430
incilarin B, Incilaria fruhstorferi: c-type lectin isolated from the body surface mucus of the land slug incilaria fruhstorferi; amino acid ; genbank ab003431
incilarin C, Incilaria fruhstorferi: c-type lectin isolated from the body surface mucus of the land slug incilaria fruhstorferi; amino acid ; genbank ab003432
incobotulinumtoxinA: contains the 150 kd neurotoxin without complexing proteins
incomplete Freund's adjuvant: mannide monooleate and mineral oil or paraffin oil; in contrast to complete freund's, this does not contain any mycobacterial cells
increpan: pancreatic tissue extracts from cattle; contains trypsin and chymotrypsin
indacaterol: a beta2 adrenoceptor agonist; indacaterol is the (r)-isomer
indacaterol acetate-mometasone furoate drug combination: fixed-dose combination of a long-acting beta agonist and an inhaled corticosteroid
indacaterol-glycopyrronium combination: a dual bronchodilator consisting of the long-acting beta2-agonist indacaterol and the long-acting muscarinic antagonist glycopyrronium (nva237) for treatment of patients with moderate to severe chronic obstructive pulmonary disease
indacrinone: polyvalent saluretic; rn given refers to parent cpd without isomeric designation
indalpine: selective 5-hydroxytryptamine uptake inhibitor; rn given refers to parent cpd
indanocine: a microtubule-binding indanone with antiproliferative activity
indantadol: nmda antagonist and nonselective mao inhibitor for the potential treatment of neuropathic pain
indaquassin C: from seeds & bark of samadera indica (simaroubaceae)
indatuximab ravtansine: has antineoplastic activity; consists of an anti-cd138 antibody linked to maytansine dm4
indazole-3-carboxylic acid: derivatives of above cpd are often antispermatogenic agents
indazolium trans-(tetrachlorobis(1H-indazole)ruthenate (III)): anticancer ruthenium compound
indenestrol A 4'-monomethyl ether: ; rn given refers to (+-)-isomer
indenestrol B 4'-monomethyl ether: ; rn given refers to (+-)-isomer
indeterminate(ID)-domain 14 protein, Arabidopsis: refseq nm_001084322
indiacen A: from the myxobacterium sandaracinus amylolyticus
indiacen B: from the myxobacterium sandaracinus amylolyticus
indicine: rn given refers to (1r-(1alpha,7(2r*,3s*),7abeta))-isomer
indicine-N-oxide: rn given refers to (1r-(1alpha,7(2r*,3s*),7abeta))-isomer
indifor: mixture of polymethylenephosphonic acids labeled with 113m indium
indimicin B: antineoplastic from the deep-sea-derived streptomyces sp. scsio 03032
indirubin 3'-(O-oxiran-2-ylmethyl)oxime: has antineoplastic activity
indisetron hydrochloride: an anti-emetic agent, indisetron hydrochloride was developed in japan
indium 1-(4-isothiocyanatobenzyl)ethylenediaminetetraacetic acid: can be attached to monoclonal antibody
indium 111-cT84.66 monoclonal antibody: used in treating presurgical colorectal cancer patients
indium DTPA-RC-160: a somatostatin receptor structurally related transmembrane glycoproteins; amino acid
indium DTPA-bis(stearylamide): putative tumor imaging agent that can be delivered to tumor cells via the receptor-mediated ldl-uptake pathway
indium In 113m sulfur colloid: used in gammagraphic evaluation of gastric and oesophageal pathology
indium oxine: rn given refers to unlabeled cpd without isomeric indication for indium
indium tetraphenylporphyrin: used in platelet labeling; rn given refers to (111)in-labeled cpd
indium(111)-ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid): used in single-photon emission computed tomography
indium-111-DTPA-CTT: ctt - a cyclic decapeptide, cctthwgftlc
indium-bleomycin: used with (111)in for combined radiotherapy & chemotherapy
indocarbazostatin: an inhibitor of nerve growth stimulated by nerve growth factor; isolated from streptomyces
indocarbazostatin B: an inhibitor of nerve growth stimulated by nerve growth factor; isolated from streptomyces
indol-3-ylacetylinositol galactoside: from maize kernels
indolacin 5-fluorouracil-1-ylmethyl ester: a prodrug of 5-fluorouracil
indolactam V: only the (-)-isomer of indolactam v showed carcinogenic activity
indole: rn given refers to parent cpd; structure in merck index, 9th ed, #4840
indole dioxygenase idoA, Pseudomonas alcaligenes: gene idoa is essential for metabolism of four-ring pah fluoranthene and its transcription is regulated by salicylate and by fluoranthene intermediates; has been sequenced
indole-3-acetaldehyde dehydrogenase, Ustilago maydis: catalyzes nad-dependent conversion of indole-3-acetaldehyde to indole-3-acetic acid; genbank u74468
indole-3-acetamide hydrolase: catalyzes the conversion of indole-3-acetamide to indolacetic acid
indole-3-acetate beta-glucosyltransferase: catalyzes the conversion of indol-3-ylacetic acid & udp-glucose to 1-o-(indol-3-ylacetyl)-beta-d-glucose & udp
indole-3-acetic acid synthase: catalyzes the conversion of tryptophan to indole-3-acetic acid; requires molecular oxygen
indole-3-acetonitrile-4-methoxy-2-C-beta-D-glucopyranoside: antineoplastic from from isatis indigotica
indole-3-acetyl-L-aspartic acid hydrolase, Pantoea agglomerans: hydrolyzes indole-3-acetylaspartic acid to indole-3-acetic acid plus aspartate; amino acid ; genbank af006687
indole-3-carboxaldehyde fluorescein hydrazone: a fluorescent probe
indole-3-ethanol oxidase: involved in conversion of indole-3-ethanol to indole-3-acetic acid; isolated from seeds of the bean phaseolus vulgaris; not stimulated by nadp or fad; do not confuse with nad- or nadp-dependent indole-3-ethanol oxidases
indole-3-ethyl isothiocyanate: synthetic cpd that enhances sensitivity of human ovarian carcinoma cell lines a2780 and a2780/cp to cisplatin
indole-3-guanylhydrazone hydrochloride: derivative of aminoguanidine hydrochloride; has anti-inflammatory properties in mice
indole-3-lactic acid: rn given refers to cpd without isomeric designation
indole-3-ylsulfonyl acetate tris-(2-hydroxyethyl)ammonium: antioxidant
indole-5-carboxylic acid: used to make hybridized graphene oxide films for biosensors
indoleacetamide: article does not mention position of acetamide group; amide of indole-3-acetic acid (iaa), the natural auxin found in plants
indoleacetic acid: rn given refers to unlabeled parent cpd; structure in merck index, 9th ed, #4841
indoleacetic acid falcarindiol ester: isolated from japanese ivy (hedera rhombea); induces granulocytic differentiation of the human leukemia cell line hl-60
indoleacetic acid-lysine synthetase: atp dependent; catalyzes formation of an amide bond between the carboxyl group of indoleacetic acid & the epsilon amino group of lysine
indoleacrylic acid: russian drug; natural auxin from lentil roots; rn given refers to parent cpd without isomeric designation
indoleethylamine N-methyltransferase: request from searcher (1973)
indolepropanol phosphate: binds specifically to the alpha subunit, but not to the beta subunit of tryptophan synthase
indolepyruvate - methylviologen oxidoreductase: catalyzes both decarboxylation of indolepyruvate and subsequent oxidation of indoleacetaldehyde into indoleacetate from a thermoacidophilic archaeon, sulfolobus; m(r) 280 kda, composed of three subunits (a, 89; b, 30; and c, 19 kda)
indolepyruvate decarboxylase: from enterobacter cloacae; amino acid sequence for ipdc gene given in first source; catalyzes the conversion of indole-3-pyruvic acid to indole-3-acetaldehyde
indolepyruvate ferredoxin oxidoreductase: catalyzes the coenzyme a-dependent oxidative decarboxylation of aryl pyruvates; indolepyruvate forms indoleacetyl-coa
indolethyl 6-N-6-(5-(2-aminoethylamino)-1-naphthalenesulfonate)-6-deoxygalactopyranosyl-1-4-glucopyranosyl-1-4-glucopyranosyl-1-4-glycopyranoside: substrate for cellulases
indolicidin: a tridecapeptide isolated from the cytoplasmic granules of bovine neutrophils; possesses potent in vitro bactericidal activity
indolicidin derivative, CP10A: an analog with alanine residues substituted for proline residues in the bovine peptide indolicidin; has improved activity against gram-positive organisms; amino acid
indolizine inhibitor 120-1032: inhibits phospholipase a2-iia complex
indolo(3,2-b)carbazole: potent inducer of cytochrome p-4501a1-dependent monooxygenase
indolyl-3-acetaldoxime dehydratase, Sclerotinia sclerotiorum: catalyzes transformation of indolyl-3-acetaldoxime to indolyl-3-acetonitrile; molecular mass 44 kda; ec number in first source
indolyl-3-alkane-alpha-hydroxylase: indoyl-3-alkane-alpha-hydroxylase; hemeprotein which needs no co-factor
indomethacin morpholinylamide: an inverse agonist of the cannabinoid cb2 receptor
indophenol oxidase: also oxidizes tetrazolium salts in the presence of phenazine methosulfate; this is not ec 1.9.3.1
indotertine B: isolated from the reed rhizosphere soil derived actinomycete streptomyces sp. chq-64
indothiazinone: from a myxobacterium belonging to the sorangiineae
indoxamycin F: an antitumor antibiotic from a marine-derived actinomycete
indoxyl-3-O-(6'-O-malonyl-beta-D-ribohexo-3-ulopyranoside): an indigo precursor from leaves of isatis tinctoria (woad)
indoxyl-UDPG-glucosyltransferase: forms indican from 3-hydoxyindole (indoxyl)
inducing factor, Lactobacillus: a peptide of 19 amino acid residues; induces bacteriocin production in lactobacillus sake; amino acid
inermin: phytoalexin produced in plants after injection with fungi; rn given refers to (cis-(+-))-isomer; rn for cpd without isomeric designation
inerminoside A: an iridoid glycoside from clerodendrum inerme
inerminoside B: an iridoid glycoside from clerodendrum inerme
ineupatorolides A: antiplasmodial sesquiterpene lactone from carpesium rosulatum
infestin protein, Triatoma infestans: a thrombin inhibitor; amino acid
inflammation modulatory protein, Cowpox virus: homologous to vaccinia virus complement control protein; amino acid
inflexarabdonin E: inhibits nitric oxide production; isolated from isodon excisus
influenza C virus glycoprotein gpII: mw appx 82k; composed of 2 disulfide-bonded subunits gp65 & gp30
influenza hemagglutinin (306-318): an influenza virus peptide fragment that induces t cell response; amino acid sequence given in first source
influenza hemagglutinin (307-319): a synthetic peptide derived from hemagglutinin of a human influenza virus strain; amino acid sequence given in first source
influenza matrix peptide (58-66): capable of being presented by class i major histocompatibility antigens
influenza matrix peptide MAT(17-31): an influenza matrix protein-derived peptide; amino acid sequence given in first source
influenza virus polymerase basic protein 1: has been sequenced; constituent of influenza virus polymerase complex
informosome: a cellular particle found in eukaryotic cells that is a complex of messenger rna and non-ribosomal protein and is thought to be the form in which messenger rna is transported from the nucleus to the site of protein synthesis in the cytoplasm
infusamine: from cattle & placental blood; contains amino acids, inositol, vitamins c, b6, pp, sorbitol & salts
ingenine A: has antineoplastic activity; isolated from acanthostrongylophora ingens
ingenine E: cytotoxic alkaloid from the indonesian sponge, acanthostrongylophora ingens
ingenol: rn given refers to (1ar-(1aalpha,2alpha,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-isomer
ingenol 3-palmitate: irritant & tumor-promoting constituent of euphorbia serrata
ingenol 6,7-epoxy-3-tetradecanoate: has antineoplastic activity; isolated from euphorbia fischeriana
ingenol dibenzoate: antileukemic component of euphorbia esula l. extract
ingenol-20-isobutyrate: rn given refers to (1ar-(1aalpha,2alpha,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-isomer
ingenol-3,5,20-triacetate: tumor-promoting factor found in honey; rn given refers to (1ar-(1aalpha,2alpha,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-isomer
ingenol-3-propionate-20-isobutyrate: rn given refers to (1ar-(1aalpha,2alpha,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-isomer
ingenol-5beta,20-O,O-isopropylidene-3beta-myristinate: from the roots of euphorbia ebracteolata hayata
ingenol-5beta,20-O,O-isopropylidene-3beta-palmitate: from the roots of euphorbia ebracteolata hayata
ingitril: antifibrinolytic; lyophilized apyrogenic prep from bovine lung tissue; russian
ingobsin: serine protease from intestinal goblet cells of rat, pig & man; cleaves lys-x & arg-x
ingol-3,7,8,12-tetraacetate: from euphorbia garuana
ingramon: synthetic anti-inflammatory peptide, a fragment of c-terminal sequence (65-76) of monocytic chemotaxic protein-1
inhibin A: the form of inhibin that is a dimer of the inhibin alpha subunit and the inhibin beta a subunit
inhibin B: the form of inhibin that is a dimer of the inhibin alpha subunit and the inhibin beta b subunit
inhibin beta A subunit: a glycopeptide and a form of beta subunit found in inhibin a, activin a, activin ab, and erythroid differentiation protein (edf); amino acid ; genbank d17357; refseq nm_002192 (human), nm_008380 (mouse), nm_017128 (rat)
inhibin-alpha subunit: a glycopeptide and subunit of the inhibin dimer
inhibin-alpha subunit precursor: a precursor of inhibin-alpha subunit; pro-alphac is one of the most abundant precursor forms of inhibin-alpha subunit found in follicular fluid and serum; amino acid sequence known
inhibitor of apoptosis 1 protein, Aedes triseriatus: a ring finger protein; genbank af447592
inhibitor of apoptosis, Nucleopolyhedrovirus: acts by blocking cellular apoptosis rather than by prevention of viral stimulation of apoptosis; amino acid sequence known
inhibitory diffusible factor 45: from mouse 3t3 cells; inhibits dna synthesis in chicken embryo fibroblasts & acts as an igf-i-binding protein
initiation factor 2, archaeal: hif-2 is a peptide initiation factor and was isolated from halobacterium halobium; amino acid
initiation factor 4F component p220: this component is proteolytically cleaved from initiation factor when cells are infected with polyovirus
initiation factor-2 kinase, Toxoplasma gondii: may be involved in bradyzoite formation; genbank ay518936
initiator binding protein, S cerevisiae: binds initiator element in gal80 gene of saccharomyces cerevisiae; amino acid
initiatorin: a prostatic endopeptidase of the silkworm, bombyx mori; initiates the protein-arginine degradation cascade in the spermatophore; partial amino acid sequence given in first source
injurin: a 10-20 kda acid- and heat-stable protein; an inducer of expression of gene for hepatocyte growth factor; seems to mediate various organ injuries in rats
inlB protein, Listeria monocytogenes: a member of the internalin family; required for entry into epithelial cells; amino acid
inlC protein, Listeria monocytogenes: a small secreted protein belonging to the family of internalins; amino acid sequence given in first source; genbank x95822 (listeria monocytogenes)
inlG protein, Listeria monocytogenes: large cell wall bound internalin isolated from listeria monocytogenes; amino acid
innate defense regulating peptide 1018: derived from bovine cathelicidin bactenecin
innate repair receptor: a heteromer of the erythropoietin receptor and the beta-common (cd131) receptor; it simultaneously activates anti-inflammatory and tissue repair pathways
inner membrane protein, E coli: hydrophobic 33,000 mw protein expressed from the left-end ecori-c fragment of phage mu
inner mitochondrial membrane peptidase 2-like protein, mouse: catalyzes signal peptide sequence processing of cytochrome c1 and glycerol phosphate dehydrogenase 2; genbank ak053361
inokosterone: minor descriptor (75-83); on-line & index medicus search cholestenes (75-83); rn given refers to (2beta,3beta,5beta,22r)-isomer
inolimomab: an antibody to il-2 receptor; used for induction of immunosuppression after liver transplantation
inonotusin A: isolated from the methanolic extract of the fruit bodies of inonotus hispidus
inonotusin B: isolated from the methanolic extract of the fruit bodies of inonotus hispidus
inophyllin A: pyranoxanthone from roots of calophyllum inophyllum (guttiferae)
inophyllum B: inophyllum p is an active enantiomer of b; from calophyllum inophyllum
inosamycins: complex of aminoglycoside antibiotics isolated from streptomyces hygroscopicus no. j296-21
inoscavin E: has free radical scavenging activity; isolated from inonotus xeranticus
inosine glycyl-cysteinyl-glutamate disodium: has antiviral, immunomodulatory, and hepatoprotective activities
inosine monophosphate synthase: catalyzes ninth and tenth steps of de novo purine nucleotide biosynthesis, converting aminoimidazole carboxamide ribonucleotide (aicar) to imp by way of n-formyl-aminoimidazole carboxyamide ribonucleotide (faicar)
inosine-adenosine-guanosine-preferring nucleoside hydrolase: a purine-specific hydrolase from trypanosoma brucei brucei; mw about 36 kda; amino acid ; genbank af017231
inosine-uridine hydrolase: from crithidia fasciculata; hydrolyzes the n-glycosidic bonds of purine and pyrimidine nucleosides
inositol 1,2,3,4,6-pentakisphosphate-2-phoshomonoesterase: metabolizes ins(1,2,3,4,6)p5 to ins(1,3,4,6)p4
inositol 1,2,3,5,6-pentakisphosphate 5-phosphatase: from fetal calf thymus; inhibited by thiol modifiers
inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Arabidopsis: genbank dq122931
inositol 1,3,4,5,6-pentakisphosphate-1-3-phosphatase: removes a phosphate group at the 1 or 3 position or at both positions of ins(1,3,4,5,6)p5
inositol 1,3,4-trisphosphate 5-6-kinase 4, Arabidopsis: inositol 1,3,4-trisphosphate 5/6-kinase 4 is an outlier to a family of atp-grasp fold proteins; it differs from other family members in that it does not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity; rather, it displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity
inositol 1,4,6-trisphosphorothioate: inhibits (1,4,5)p3/(1,3,4,5)p4-polyphosphate 5-phosphate
inositol 1,4-bis(phosphate): induced in human platelets by thrombin; rn given refers to cpd without isomeric designation
inositol 1-alpha-galactosyltransferase: catalyzes conversion of udpgalactose plus myo-inositol to galactinol plus udp
inositol 2,3,5-trisphosphorothioate: a partial agonist at the platelet inositol 1,4,5-trisphosphate receptor
inositol 3,4-bisphosphate: rn given for (d)-isomer
inositol 4,5-bisphosphate: rn given refers to cpd without isomeric designation
inositol 4-phosphate: rn given refers to (dl-myo)-isomer
inositol NAD epimerase: converts myo-inositol to scyllo-inositol & neoinositol; inosose also formed & reverse reaction
inositol O-methyltransferase: from mesembryanthemum crystallinum; uses s-adenosyl-l-methionine to methylate myo-inositol to form d-ononitol; monomeric mass 41 kda; has been sequenced
inositol cyclic 1,2-phosphate 1-phosphodiesterase: converts inositol 1:2-cyclic phosphate to inositol 2-phosphate; do not confuse with inositol 1,2 cyclic-phosphate 2-phosphohydrolase see annexin iii
inositol hexakisphosphate kinase: catalyzes formation of diphosphoinositol pentakisphosphate (pp-ip5) from inositol hexakisphosphate; the reverse reaction acts as an atp synthase; refseq nm_016291 (ihpk2), nm_054111 (ihpk3)
inositol nicotinate, mefruside, reserpine drug combination: contains reserpine, mefruside & inositolnicotinate
inositol pentakisphosphate kinase: has pronounced substrate specificity for d-inositol-1,2,4,5,6-pentakisphosphate which it converts to inositol hexakisphosphate
inositol phosphate glycan: biologically active extracts from rat skeletal muscle & rat adipocytes; insulin mediator
inositol polyphosphate multikinase: catalyzes the formation of either inositol 1,4,5-trisphosphate or disphosphoinositol tetrakisphosphate from inositol 4,5-bisphosphate; genbank ay014898
inositol polyphosphate receptor: consists of three different polypeptides with mw of 111, 102 & 52 kda
inositol requiring enzyme-1, Drosophila: ire1 independently mediates the rapid degradation of a specific subset of mrnas, based both on their localization to the endoplasmic reticulum membrane and on the amino acid sequence they encode
inositol triphosphate phosphomonoesterase: do not use for the enzyme which converts inositol 1,4,5-trisphosphate into inositol 1,4-bisphosphate, that is ec 3.1.3.56
inositol trispyrophosphate: suppresses hif-1alpha; has antineoplastic activity
inositol-1,2-cyclic-4,5-triphosphate: formed upon thrombin stimulation of human platelets
inositol-1,3,4,5,6-pentakisphosphate: involved in signal transduction
inositol-1,3,4,5-tetrakisphosphate: for cpd without numerical locants of phosphate groups, index inositol phosphates
inositol-1,3,4,5-tetrakisphosphate receptor: stimulates the gtpase activity of normal ras p21 but not its oncogenic counterpart; genbank ab028626 (rat); refseq nm_007368 (human)
inositol-1,3,4,6-tetrakisphosphate: for cpd without numerical locants of phosphate groups, index inositol phosphates
inositol-1,4,5,6-tetrakisphosphate: for cpd without numerical locants of phosphate groups, index inositol phosphates
inositol-1,4-bisphosphate 1-phosphatase: acts only on inositol (1,4)-bisphosphate & inositol (1,3,4)-trisphosphate; fiery1 is a negative regulator of abscisic acid and stress signaling in arabidopsis
inositol-1,4-bisphosphate 4-phosphohydrolase: soluble rat brain enzyme highly specific for inositol 1,4-bisphosphate; does not act on inositol 1-phosphate or inositol 1,4,5-trisphosphate
inositol-3,4,5,6-tetrakisphosphate: for cpd without numerical locants of phosphate groups, index inositol phosphates
inositol-P-(mannosylphosphatidylinositol): inositol glycerophospholipid that mimics sphingolipid structures
inositol-tetrakisphosphate 1-kinase: a 46 kda enzyme from rat liver
inperatorin: used as a pigmentation agent for the treatment of vitiligo vulgaris
inproquone: major descriptor (78-80); replaced major descriptor bayer e39 (63-77); on-line search azirines (66-80); index medicus search bayer e39 (63-77), inproquone (78-80)
inrpk1 protein, Ipomoea nil: a receptor kinase isolated from pharbitis; amino acid ; genbank u77888
insA1 protein, E coli: encoded by is1 and binds specifically to the terminal inverted repeats of this insertion sequence, negatively regulates is1 transposition activity; amino acid sequence has been deduced
insc protein, Drosophila: neural precursor protein and possible cytoskeleton adaptor protein; genbank x83111
inscuteable protein, mouse: an adaptor protein involved in asymmetric cell division; refseq nm_173767
insect defensin A: mw 4 kda; 40 amino acid residues given in first source; from phormia terranovae
insect defensin B: mw 4 kda; 40 amino acid residues given in first source; from phormia terranovae
insect defensin D: from aedes albopictus; amino acid ;genbank af087815
insecticidal crystal protein, Bacillus Thuringiensis: insecticidal crystal proteins are a group of bacterial endotoxins encoded by strains of b. thuringiensis during sporulation and deposited in the cytoplasm as inclusions; control agricultural pests; has been partially sequenced
insecticyanin protein, insect: blue biliprotein from hemolymph of tobacco hornworm; amino acid sequence given in first source; mw 21,378; 189-amino acids; do not confuse with biliverdin-associated cyanoprotein, from bean bug, riptortus clavatus
insectotoxin I5A: amino acid sequence has been determined; from buthus eupeus
insertin protein, chicken: amino acid sequence given in first source; amino acid residues 862 to 1212 are identical to tensin
insta-gel: xylene-based liquid scintillation cocktail for tritium counting of aqueous samples; contains surfactant for homogenizing sample
insularin, Bothrops insularis: inhibits platelet aggregation and endothelial cell adhesion
insularinase A, Bothrops insularis: a prothrombin activator; amino acid
insulin aspart, insulin aspart protamine drug combination 30:70: 30% soluble, rapid-acting insulin aspart and 70% intermediate-acting protamine-bound aspart drug combination
insulin covalent aggregate: mw 12,000; found in blood of patients with type i diabetes mellitus
insulin crosslinked to the catalytic fragment A of diphtheria toxin: insulin crosslinked to the catalytic fragment a of diphtheria toxin; chimeric insulin is cytotoxic to cells with functioning insulin receptor
insulin dimers: dimers containing oxalyl, suberoyl & dodecanedioyl cross-links have been produced; showed potencies between 1-60% that of insulin on weight basis in stimulating lipogenesis in isolated fat cells
insulin fragment A(14-21)-B(17-30): produced from porcine insulin by insulin proteinase
insulin gene enhancer binding protein Isl-1: isl1 is a transcription factor that may regulate insulin gene expression or islet cell development; isl2 is a lim homeobox transcription factor involved in topographic organization of motor neurons; refseq nm_021459 (isl1, mouse); nm_017339 (isl1, rat); nm_002202 (isl1, human); nm_145805 (isl2, human); nm_027397 (isl2, mouse); nm_020471 (isl2, rat)
insulin lispro, isophane insulin lispro drug combination (25:75): contains insulin lispro & insulin lisproprotamine in a ratio of 25:75%
insulin proreceptor: mw 190,000 single-chain precursor that contains exclusively asparagine-n-linked high-mannose-type carbohydrate chains
insulin receptor peptide (1135-1156): a synthetic peptide representing the putative g-binding site in the cytosolic domain of the insulin receptor; amino acid sequence given in first source
insulin receptor serine kinase: putative enzyme that may be part of the insulin receptor, both serine-threonine & tyrosine phosphorylation are required for activation of irs kinase; activated also by casein kinase-1,-2,-3
insulin receptor-related receptor: similar to the insulin receptor & insulin-like growth factor i receptor; receptor for insulin, igf-i, igf-ii or an as yet unidentified peptide hormone or growth factor belonging to the insulin family; refseq nm_014215 (human); refseq nm_011832 (mouse); refseq nm_022212 (rat)
insulin resistance factor (uremia): small molecular weight circulating peptide, unique to uremia, which induces insulin resistance by a protein synthesis-dependent mechanism
insulin response element binding protein, human: transcriptional regulator which plays an important role in controlling tissue specificity of the insulin response; amino acid sequence given in first source
insulin response element binding protein, rat: transcriptional regulator which plays an important role in controlling tissue specificity of the insulin response; amino acid sequence given in first source
insulin secretory granule membrane glycoprotein 110: mw 110kda; from insulin secretory granule; used to study granule biogenesis
insulin, (2-nitro-4-azidophenyl)(A1)-: photoreactive insulin derivative; used also for affinity labeling
insulin, (2-nitro-4-azidophenylacetyl) (B29)-: photoreactive insulin derivative; used also for affinity labeling
insulin, (2-nitro-4-azidophenylacetyl)(B2)-des-Phe(B1)-: labeled with 125i
insulin, (2-nitro-azidophenylacetyl)(B1)-: photoreactive insulin derivative; used also for affinity labeling
insulin, 4-succinylamidophenylglucopyranoside-: monosaccharide-modified insulin derivative
insulin, 4-succinylamidophenylmannopyranoside-: monosaccharide-modified insulin derivative
insulin, lente, pork: lente insulin that is derived from pork or that contains the porcine insulin sequence
insulin, long-acting, beef: long-acting formulation of insulin that is derived from beef or that contains the bovine insulin sequence
insulin, long-acting, human: long-acting formulation of insulin that is derived from human or that contains the human insulin sequence
insulin, pork; isophane insulin, pork drug combination 30:70: mixtard was entry term to insulin, long-acting 1982-2011
insulin, protamine zinc, beef-pork: insulin, protamine zinc, beef-pork was an entry term to insulin, long acting 2003-2011
insulin-binding peptide: inhibits insulin binding to the receptor by 50% but has no effect on insulin action
insulin-cleaving membrane proteinase: membrane proteinase from pseudomonas aeruginosa cleaves glu(13)-ala(14) and tyr(16)-leu(17) of insulin b-chain; phe(25)-tyr(26) and his(10)-leu(11) are secondary cleavage sites; partial amino acid
insulin-dependent cytoplasmic regulator protein, rat: also a regulator of mitochondrial membrane permeability
insulin-glucagon liberin: tridecapeptide that enhances insulin & glucagon release from isolated islets of langerhans; extracted from hypothalami
insulin-like growth factor 1, des-(1-3)-: insulin-like growth factor 1 that lacks the n-terminal tripeptide gly-pro-glu
insulin-like growth factor 1A prohormone (91-103): 13 amino acid segment of e peptide region
insulin-like growth factor I-Pseudomonas exotoxin A (40): igfi fused to pseudomonas exotoxin a; has antitumor effect on human glioblastoma multiforme cells
insulin-like growth factor binding protein, acid labile subunit: amino acid sequence given in first source; combines with igf-i or igf-ii and either bp-53 or igfbp-3 to form the heterotrimeric insulin-like growth factor-binding protein complex
insulin-like growth factor binding protein-3 protease: calcium-dependent protease present in human pregnancy serum yielding igf; inhibited by edta & phenanthroline; not present in baboon serum but may be present in rhesus monkey serum; however the protease splits this protein at a different site
insulin-like growth factor binding proteinase, human: a protease shown to degrade igfbp-5; amino acid
insulin-like material, blowfly brain: displays both immunologic & biologic insulin-like activity
insulin-like peptide 7, Drosophila: findings suggest that selection of egg-laying site involves a simple decision-making process and provide an entry point toward a systematic dissection of this process
insulin-like peptide 8, Drosophila: refseq nm_140692.3
insulin-like protein 6-kDa, Panulirus argus: a protein from hepatopancreas of lobster panulirus argus with insulin-like effects
insulin-related factor: mw 6-kda; from insulin-independent cell line 1246-3a; similar to pancreatic insulin; has growth-promoting activity
insulin-related neuropeptide: produced by neuroendocrine light green cell of lymnaea; stimulates neurite outgrowth in dissociated neuronal cell cultures
insulin-related peptide I: from lymnacea stagnalis; synthesized in neurons in the brain; amino acid
insulin-related peptide III, Lymnaea: from lymnacea stagnalis; synthesized in neurons in the brain; encoded by a gene with the overall organization of the vertebrate insulin genes; aa sequence given in first source
insulin-related peptide, Crassostrea gigas: the deduced preprohormone was a polypeptide of 161 residues and showed a conformation typical of preprohormones of the insulin superfamily, which included conserved amino acids necessary to adopt the globular insulin structure; amino acid
insulin-stimulated MEK kinase: distinct from mek kinase & raf-1 kinase; represents a divergence point between signal transduction pathways mediated by insulin & those activated by protein kinase c
insulin-stimulated phosphoprotein pp105: mw 105kda; found in lizzard brain insulin receptors; its phosphorylation is stimulated by insulin
insulin-stimulating peptide, human: 71-amino acid containing peptide; corresponds to residues 115-143 & 144-184 of bovine serum albumin with the exception of a tyrosine insertion between residues 155 & 156; consists of two chains with mw 5000 & 3400 for each chain
insulinase related protease: 38.5% identical to ste23; involved in m-factor processing; amino acid ; do not confuse with iron regulatory factor
intectin protein, mouse: an intestine-specific gpi-anchored protein that accelerates apoptosis; genbank ak018552
integerrimide A: bioactive cyclic heptapeptide from the latex of jatropha integerrima
integerrimide B: bioactive cyclic heptapeptide from the latex of jatropha integerrima
integra artificial skin: collagen-gag matrix; a dermal template consisting of bovine collagen, chondroitin-6-sulphate and a silastic membrane manufactured as integra
integracide A: 3-sulfate ester of integracide b; hiv-1 integrase inhibitor
integracin A: potent hiv-1 integrase inhibitor from chinese mangrove plant sonneratia hainanensis
integracin B: potent hiv-1 integrase inhibitor from chinese mangrove plant sonneratia hainanensis
integral fibrillar protein, class I protein, Myxococcus xanthus: an integral protein of the extracellular matrix fibrils of myxococcus xanthus; amino-terminal amino acid sequence of isoform icp-1:31 given in first source
integral membrane protein 2b, rat: expression is upregulated by testosterone and might play a role in male reproduction; refseq nm_001006963.1
integrasone: hiv-1 inintegrase inhibitor & a fungal polyketide
integrasone B: trypanocidal from microthyriaceae sp., an endophytic fungus from a tropical grass
integrin alpha 10: associates with beta1 subunit, forming the alpha10beta1 integrin; amino acid
integrin alpha 7 beta 1, mouse: concentrated at the costameres of skeletal muscle
integrin alpha4beta7: antigenically related to the human vla-4 integrin chain; amino acid sequence of the alpha chain in first source
integrin alpha7: refseq nm_001144996 (alpha-7 isoform 1 human); nm_008398 (alpha-7 mouse)
integrin alpha7beta1: isoform of a laminin receptor developmentally regulated in skeletal muscle; partial amino acid sequence given in first source; genbank l16544
integrin alpha8beta1: promotes attachment, cell spreading & neurite outgrowth on fibronectin
integrin alpha9: associates principally with the integrin beta(1) subunit; detected in human carcinoma cell lines, tera-2 and caco-2; has 1006 amino acid residues; shares 39% identity with integrin alpha4; amino acid sequence given in first source; genbank l24158; likely to be designated future cd antigen
integrin alphaD, mouse: a subunit of the integrin alphadbeta2 receptor; refseq nm_001029872
integrin alphaEbeta7: an intestinal t-lymphocyte associated molecule; a trimeric protein of 150, 125, & 105 kda; hml-1 integrin is composed of the beta(7) subunit in association with the alpha(e) subunit; e stands for epithelial-associated
integrin alphaHr1, Halocynthia roretzi: al complement type 3 receptor-like protein isolated from the ascidian halocynthia roretzi; amino acid
integrin alphaVbeta5: adhesion receptor for vitronectin & osteopontin
integrin alphaupsilonbeta6: plays an important role in the progression of colon cancer cells and a prognostic indicator for aggressive colon cancer in humans
integrin beta1C: an unspliced form of the integrin beta1 subfamily, inhibits cell proliferation in vitro
integrin beta5: the beta5 subunit of integrin alpha(v)beta(5); aa sequence given in first source; genbank l12231; likely to be designated future cd antigen
integrin beta7: the beta7 subunit of the integrins alphaebeta7 & alpha4beta7 (lymphocyte-peyer's patch adhesion molecule); likely to be designated a cd antigen in the future
integrin betaL, Strongylocentrotus purpuratus: a beta integrin subunit that is expressed during early embryogenesis in the sea urchin embryo; amino acid ; genbank af078802
integrin modulating factor 1: a lipid that alters the function of leukocyte integrins; may be an unsaturated fatty acid or an isoprenoid acid
integrin, leukocyte response: expressed by human neutrophils & monocytes; most closely related to beta3 integrin family; its ligand specificity may be regulated by the activation state of the cell
integrin-linked kinase: regulates cell adhesion and anchorage-dependent growth; mw 59 kda; ilk-2 is an isoform
integron integrase IntI1: a site-specific recombinase found in class 1 integrons that catalyzes the excision & integration of mobile gene cassettes belonging to the tyrosine recombinase (phage integrase) family; has been sequenced
integron-associated beta-lactamase 1: an integron-associated class a beta-lactamase with extended-spectrum properties produced by an enterobacter cloacae clinical strain; amino acid
intellan: contains centella asiatica, bacopa monniera, coriandum sativum, amomum subulatum, emblica officinalis and another product cytacon (cyanocobalamine); nootropic agent
inter-alpha-inhibitor: inhibits bovine trypsin & chymotrypsin; complex formed with chymotrypsin less stable; alpha-glycoprotein; shap - serum-derived hyaluronan associated protein; refseq nm_002215 (itih1, human), nm_002216 (itih2); nm_002217 (itih3)
interaptin protein, Dictyostelium discoideum: an actin-binding protein of the alpha-actinin superfamily in dictyostelium discoideum, associates with intracellular membrane compartments; amino acid
intercedenside A: cytotoxic triterpene glycoside from the sea cucumber mensamaria intercedens lampert
intercedenside B: cytotoxic triterpene glycoside from the sea cucumber mensamaria intercedens lampert
intercedenside C: cytotoxic triterpene glycoside from the sea cucumber mensamaria intercedens lampert
interferon alfa-2c: a recombinant form of interferon alpha-2c. this variant has arginine at position 23 and position 34
interferon alfa-n1: an interferon alpha-2 preparation obtained from cultured lympohblastoid cells. it is a purified (non-recombinant) mixture of glycosylated human interferon alpha proteins
interferon alfacon-1: recombinant interferon alphaf with 10 different amino acid positions
interferon alpha, HY-3: recombinant hybrid interferon; amino acid ; genbank af085805
interferon eicosapeptide (human lymphoblastoid): eicosapeptide, h-ser-asp-leu-pro-gln-thr-his-ser-leu-gly-asn-arg-arg-ala-leu-ile-leu-leu-ala-gln-oh, corresponding to n-terminal aa sequence of major component of human lymphoblastoid interferon
interferon gamma (1-39): synthetic peptide corresponding to a receptor-binding domain of mouse interferon gamma
interferon gamma, Cys(-3), Tyr(-2), Cys(-1)-: gamma interferon with amino terminus sequence cys-tyr-cys; produced in e coli
interferon gamma-1b: a n-terminal methionyl form of interferon gamma with peptide length of 140 amino acids, produced by recombinant dna technology
interferon gamma-4A: nonglycosylated recombinant form of ifn-gamma that has the same specific antiviral activity as the ifn-gamma purified from natural sources; amino acid sequence of ifn-gamm4a is identical to the secreted material but contains methionine at the amino terminus; closely resembles the 143 amino acid ifn-gamma
interferon regulatory factor, flounder: member of irf family from japanese flounder, paralichthys olivaceus; most closely related to chicken irf-2 (72% identity); has 40% identity with avian & mammalian irf1 & irf2; amino acid
interferon regulatory factor-10, Gallus gallus: has a unique role in immune defense and is induced by the v-rel oncoprotein; genbank af380350
interferon regulatory factor-4: binds the interferon-stimulated response element (isre); mw 51 kda; refseq nm_002460 (human); nm_013674 (mouse)
interferon regulatory factor-8: interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class i genes; refseq nm_008320 (mouse); nm_002163 (human); nm_001008722 (rat)
interferon repressor protein, mouse: irp is localized in cell sap and in ribosomal fraction of mouse cells; initially identified in chick embryo fibroblasts in state of hyperreactivity to repeated induction of poly(ri)poly(rc)
interferon tau: antiluteolytic protein present in early pregnancy in sheep & bovine embryo; it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity; do not confuse with tyrosinase-related protein 1 (trp-1); genbank m31557 & m31556 (bos taurus)
interferon, alpha 2(1-110): thermolysin digested fragment of recombinant human interferon alpha2; see also related complementary fragment (111-153)
interferon, alpha 2(111-153): thermolysin digested fragment of recombinant human interferon alpha2; see also related complementary fragment (1-110)
interferon, delta: interferon from human mononuclear leukocytes, antigenically distinct from alpha, beta, or gamma
interferon-alpha 8: used in the treatment of cancer and virus related diseases; possess antiproliferative & antiviral activities
interferon-alpha A-D: composed of the first 61 amino acids of rhuifn-a(interferon, alpha 2) joined to the terminal 104 amino acids of rhuifn-d(interferon alpha 1b) at a common bg1 ii restriction site
interferon-alpha B-D: a hybrid ifn constructed with an n-terminal part & a c-terminal part of ifnalpha b (-alpha1) combined with an ifnalpha d (-alpha8)-derived middle part (ifnalpha bdbb)
interferon-alpha, immunoglobulin-linked: a recombinant human interferon-alpha (rhifn-alpha) linked to immunoglobulin via n-terminal-specific non-peptidyl polyethylene glycol linker to improve the in vivo stability of interferon
interferon-lambda protein, mouse: member of the class ii cytokine family and shown to possess antiviral activity
intergel: an ionically cross-linked ferric hyaluronate used to reduce postsurgical adhesions
interleukin 1 precursor: mw 33,000 protein enzymatically cleaved to low mw form
interleukin 13 antagonist E13K: an il13 recombinant mutant where glu position 13 is substituted by lys
interleukin 16 precursor: amino acid sequence given in first source; genbank u82972
interleukin 1beta-converting enzyme 2: flice2 - fadd-like ice 2; similar to interleukin-1beta converting enzyme (flice/mach/ice/ced-3); involved in cd95- & p55-mediated death signaling; amino acid sequence given in first source
interleukin 2 inhibitor: mw 11,000 t0 12,000; inhibits il-2 but not il-3-dependent proliferation
interleukin 2-PE66(4Glu) protein, recombinant: il-2 attached to a pseudomonas exotoxin in peptide linkage; cytotoxic to human-activated t lymphocytes
interleukin 20: stimulates a signal transduction pathway through stat3 in a keratinocyte cell line; amino acid
interleukin 4 (1-129)-PE38KDEL: a chimeric recombinant toxin in which residue 129 of il-4 is joined to the n-terminus of pe38kdel