NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
carbon monoxide dehydrogenase: co is oxidized to co2; carbon dioxide may be reduced to formate; co dehydrogenase contains a (ni/fe-s) enzyme and a (corrinoid/fe-s) enzyme component; has co-beta-methylcobamide/tetrahydropteridine methyltransferase and acetyl-coa synthase activities
carbon monoxide dehydrogenase disulfide reductase: catalyzes a reversible exchange of coash with acetyl-coa in combination with carbon monoxide dehydrogenase (ec 1.2.99.2)
carbon monoxide-methylene blue oxidoreductase: molybdenum-containing iron-sulfur flavoprotein from pseudomonas carboxydovorans; forms carbon dioxide
carbon-11 methionine: rn refers to l-methionine labeled with carbon-11
carbon-phosphorus lyase: found in bacteria which utilize alkyl & phenylphosphonic acids
carbonyl 3-chlorophenylhydrazone: inhibitor of atp synthesis; inhibits iron-containing nitrile hydratases
carbonyldiphosphonate: inhibitor of mammalian dna polymerase delta; rn given refers to parent cpd
carboranyl oligophosphate CB10: rn refers to sodium salt; an oligomeric nido-carboranyl phosphate diester with an amino group at the pseudo-5'-terminus and a thymidine at the pseudo 3'-terminus
carboranyl-5-TDGP: tdgp - 5-thio-d-glucopyranose
carboranylalanine: has a 1,2-carborane cage in place of benzene ring of phenylalanine
carborundum: a synthetic abrasive manufactured through fusion of high grade silica sand and finely ground carbon in an electric furnace at 2,400 degrees c; has fibrogenic activities comparable to asbestos fibers of similar size and likely to contribute to the pathogenesis of the interstitial lung disease of carborundum workers
carbovir-5'-O-glucuronide: glucuronidation of carbovir is used as a transient intermediate metabolic step in the elimination of carbovir
carboxamidopeptidase: has both trypsin & chymotrypsin-like activities; neurohypophyseal hormone inactivating peptidase from toad skin
carboxy-seminaphtorhodafluor-2-acetoxymethyl ester: a membrane-permeable fluorescent dye
carboxy-terminal domain kinase: protein kinase that phosphorylates the c-terminal repeat domain of the largest subunit of rna polymerase ii at serine residues
carboxy-terminal domain phosphatase: dephosphorylates carboxy-terminus of rna polymerase ii; tapp is a type 1 ser/thr protein phosphatase
carboxyamido-triazole: ; coccidiostat; u.s. patent no. 4,590,201
carboxyaminoimidazole ribotide: reacts with alanosine to form antimetabolite; substrate for ec 4.1.1.21
carboxyatractylate-binding protein, rat: purified from rat liver mitochondria
carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone: inhibits trypsin-like, chymotrypsin-like, and peptidyl-glutamyl peptidase activities in proteasomes
carboxycinnamic acid bishydroxamide: inhibits histone decacetylase i & 3
carboxydihydroresveratrol 3-O-beta-glucopyranoside: from metasequoia glyptostroboides, a tree native to china
carboxyeremomycin bis-benzylamide: eremomycin derivative
carboxyethylphosphoramide mustard: a 4-hydroxycyclophosphamide metabolite
carboxylatopillar(6)arene: a water-soluble macrocyclic arene
carboxylesterase Est30, Bacillus: from bacillus stearothermophilus
carboxylic acid reductase (tungsten-containing): enzyme from clostridium thermoaceticum; contains tungsten; reduces non-activated carboxylic acids to aldehydes at the expense of reduced viologens
carboxymethyl hydroxyethyl starch-(Gd-DO3A)(35): a polysaccharide macromolecular contrast agent for mr imaging
carboxymethyl konjac glucomannan: had colon-specific enzymatic degradation characteristics and could be used as carrier material to prepare colon-specific drug delivery systems. konjac glucomannan is isolated from amorphophallus konjac
carboxymethyl polyhistidine: ph-sensitive protein for polyplex gene delivery enhancement
carboxymethyl-beta-1,3-glucan: rn given refers to (d)-isomer with specified locants
carboxymethyl-gamma-cyclodextrin: used to form inclusion complexes with some antineoplastic agents
carboxymethyldextran-thiomannopyranoside-pyrimethamine: a pyrimethamine prodrug
carboxymethylmonobenzocyclooctyne: a non-fluorinated compound for rapid copper-free click reactions
carboxymethylproline synthase: catalyzes the conversion of malonyl-coa and glutamate semialdehyde to 5s-(carboxymethyl)-s-proline
carboxymethylselenopyruvic acid: produced by oxidative deamination of carboxymethylselenocysteine
carboxymucins: more carboxymucins in non-neoplastic bile ducts than in corresponding malignant ones determined by staining
carboxynorspermidine decarboxylase: the last enzyme in norspermidine biosynthesis
carboxynorspermidine synthase: catalyzes reductive condensation of l-aspartic beta-semialdehyde with diaminopropane to form carboxynorspermidine & water; requires nadph
carboxypentitol bisphosphate: mixture of carboxyarabinitol and carboxyribitol bisphosphates
carboxypeptidase B activation peptide: a peptide of 95 amino acids, stable in serum & urine; concentration is linked to severity of acute pancreatitis
carboxypeptidase D: a yeast type i transmembrane carboxypeptidase involved in precursor processing; has been sequenced
carboxypeptidase G3: hydrolyzes predominantly acidic peptides and n-acyl amino acids with glu or asp in the c-termini; inhibited by metal chelators; different from carboxypeptidases g1 and g2 in that it also acts on d-amino acids and shows affinity for long chain fatty acyl groups but not benzoyl
carboxypeptidase L: cathepsin a (also named "protective protein" and carboxypeptidase l) stabilizes beta-galactosidase and activates neuraminidase by forming with them a high-molecular-weight lysosomal complex
carboxypeptidase M: from human placental microvilli; mw 62kda; cleaves arg or lys from the cooh terminus of synthetic peptides as well as several biologically active substrates; membrane-bound; structurally, catalytically & immunologically distinct from carboxypeptidase a,b,n & h
carboxypeptidase PC: a metallocarboxypeptidase isolated from hematopancreas of kamchatka crab; activated by co(+) and ca(2+) ions; splits off c-terminal residues phe, tyr, arg, & lys; mw 34 kda; amino acid composition given in first source; has been sequenced
carboxypeptidase R intracellular inhibitor: from rhodotorula glutinis
carboxypeptidase ysc-alpha: membrane-associated carboxypeptidase; possibly involved in removal of carboxy-terminally remaining lys-arg residues after endoproteolytic cleavage of saccharomyces cerevisiae alpha-factor precursor
carboxypeptidase-aminoacylase PP: isolated from pyrococcus horikoshii; genbank ab00950
carboxyphosphamide: metabolite of cyclophosphamide; rn given refers to cpd without isomeric designation
carboxyphosphonoenolpyruvate phosphonomutase: catalyzes the rearrangement of the carboxyphosphono- group of carboxyphosphoenolpyruvate to form the c-p bond of phosphinopyruvate; an intermediate in the biosynthesis of the antibiotic bialaphos
carboxyphosphonoenolpyruvate synthase: catalyzes the transesterification between phosphoenolpyruvate and phosphonoformate in the bialaphos biosynthetic pathway; amino acid sequence given in first source; genbank d37878
carboxyphthalato-1,2-diaminocyclohexaneplatinum: rn given refers to hydrogen(sp-4-3(1r-trans))-isomer
carboxypiperazinyl propylphosphonic acid: a competitive nmda receptor (receptors, n-methyl-d-aspartate) antagonist
carboxysalsolinol: condensate of l-dopa & acetaldehyde; potentiates ethanol narcosis; rn given refers to parent cpd without isomeric designation
carbuterol: sympathomimetric specific for beta2 receptors; proposed bronchodilator agent; minor descriptor (78-86); on-line & index medicus search ethanolamines (78-86); rn given refers to parent cpd
carbylan-GSX: a disulfide cross-linked hydrogel of hyaluronan and gelatin that is used as an extracellular matrix
carcinine synthetase: requires atp, beta-alanine, histamine, mg2+ and dithiothreitol; forms beta-alanylhistamine(=carcinine)
carcinoembryonic antigen binding protein, human: activity attributed to heterogeneous nuclear ribonucleoprotein m. see c440104, hnrnpm protein, human
carcinoma-associated antigen 17-1A: nucleotide sequence & predicted amino acid sequence given in first source
carcinoma-associated antigen 494: a carbohydrate epitope on a high-molecular-weight-type glycoprotein
cardanol: from pink pepper; phenol with hydrocarbon side chain which can vary in length & unsaturation
cardiac antisecretory peptide: inhibits vip- & ionomycin-induced chloride secretion in rat ileum
cardiac myosin light chain kinase, mouse: refseq nm_001297612.1
cardiac natriuretic peptide, Salmo salar: a cardiac peptide hormone, heart-specific gene; amino acid
cardinalisamide A: from the insect pathogenic fungus cordyceps cardinalis
cardinalisamide B: from the insect pathogenic fungus cordyceps cardinalis
cardinalisamide C: from the insect pathogenic fungus cordyceps cardinalis
cardioacceleratory peptide 2b: isolated from the tobacco hawkmoth manduca sexta; see also adipokinetic hormone
cardioactive hexapeptide: c-terminal sequence of lh-rh; rn given refers to parent cpd
cardiodigin: factor extracted from mammalian heart; cross-reacts with digoxin antibodies & has digitalis-like activity
cardiodilatin: polypeptide hormone from various vertebrate hearts, regulates smooth muscle function; synthesized as a preprohormone of 149-153 amino acids (=atrial natriuretic factor precursors); released as a 28-amino acid peptide into blood; amino acid sequence given in first source; possesses potent vasorelaxant but not natriuretic & diuretic activities
cardiolipin synthetase: catalyzes phosphatidylglycerol & cdpdiglyceride to cmp & diphosphatidylglycerol (cardiolipin); minor descriptor (75-83); on-line & index medicus search phosphotransferases (75-83)
cardiospermin: anxiolytic from roots of cardiospermum halicacabum
cardiotin: a 300 kda sarcoplasmic reticulum-associated protein with homology to alpha-actinin; n-terminal amino acid
cardiotoxic factor (leukemia): 1000 to 5000 dalton fraction from leukemic serum & blast cell extract; decreased amplitude of left ventricular contraction & decreased oxygen uptake in isolated rabbit heart
cardiotoxin III, Naja naja atra: has been sequenced; genbank aj007796
cardiotoxin, crotoxin drug combination: a 3:1 mixture of cardiotoxin and crotoxin that exhibits cytotoxic disease specificity with reduced neurotoxic effects from crotoxin
cardiotrophin 1: a cytokine that induces cardiac myocyte hypertrophy; member of the leukemia inhibitory factor/ciliary neurotrophic factor/oncostatin m/interleukin 6/interleukin 11 family of cytokines; mw 21.5 kda; amino acid sequence given in first source; genbank u18366
cardiotrophin-like cytokine: a member of the neuropoietic cytokine family; has been sequenced
careaborin: a phytogenic antineoplastic agent isolated from rhizophora stylosa
carenone: is an antioxidant isolated from medicinal plant, carissa spinarum
carfilzomib: an antineoplastic agent that inhibits the ubiquitin-proteasome pathway
carglumic acid: carglumic acid could be helpful in lowering plasma ammonia levels over 400 micromol/l more rapidly
caricain II: an 18.8-kda enzyme equivalent to caricain lacking the first 41 residues and one disulfide bond
carijenone: a class of bicyclic prostanoid from the eastern pacific octocoral carijoa multiflora
carinactivase: prothrombin activator isolated from venom of echis carinatus
carinatumin A: alkaloid from lycopodium carinatum inhibiting acetylcholinesterase
carinatumin B: alkaloid from lycopodium carinatum inhibiting acetylcholinesterase
carinatumin C: alkaloid from lycopodium carinatum inhibiting acetylcholinesterase
carinoside A: from lomatogonium carinthiacum (wulf) reichb.
carlinoside: from cajanus cajan leaf; reduces hepatic bilirubin accumulation
carlumab: targets cc-chemokine ligand 2; has antineoplastic activity
carmegliptin: a hypoglycemic agent that inhibits dipeptidyl peptidase iv
carmethizole: rn & ; rn given refers to hcl; rn for parent cpd not available 2/89
carmin protein, Carthamus tinctorius: from the safflower seed (carthamus tinctorius)
carminomycin 4-O-methyltransferase: catalyzes the final step in daunorubicin biosynthesis
carmoterol: chf4226.01 and chf4232.01 are diastereoisomers
carmustine with prolifeprosan 20: a lipid soluble agent capable of crossing the bbb and achiving potentially tumoricidal concentrations
carnauba wax: exudate from pores of leaves of brazilian wax palm tree; used as polish for automobiles, floor, shoes etc
carneic acid A: antimicrobial agent from the xylariaceous ascomycete hypoxylon carneum
carneic acid B: antimicrobial agent from the xylariaceous ascomycete hypoxylon carneum
carnitine amidase: hydrolyzes l-carnitine amide steroselectively
carnitine palmitoyltransferase-1a, rat: refseq nm_031559
carnitintartrate: topical l-carnitin-l-tartrate promotes human hair growth in vivo
carnocin UI49: a lantibiotic isolated from carnobacterium piscicola
carocin S1, Erwinia carotovora: low-molecular-weight bacteriocin of the erwinia carotovora subsp. carotovora; genbank af205141
carolenalin: guaianolide--sesquiterpene lactone from helenium autumnale l.
carolenin: guaianolide--sesquiterpene lactone from helenium autumnale l.
caronte protein, Gallus gallus: a cerberus-related gene product that establishes left-right asymmetric gene expression; amino acid
carotenoid 1,2-hydratase: the acyclic carotenoid 1,2-hydratase from rubrivivax gelatinosus; catalyzes the conversion of various acyclic carotenes including 1-hydroxy derivatives
carotenoid cleavage dioxygenase 1: isolated from arabidopsis thaliana; amino acid ; do not confuse with ccd1 protein
carotenoid oxygenase: catalyzes conversion of beta-apocarotenals to retinal
carotuximab: an antineoplastic agent that targets cd105; in phase i clinical trials (2013)
carp vitellogenic gonadotropin: differs from carp maturational-ovulatory gonadotropin; does not stimulate testosterone production by rat leydig cells
carpamidase: amidolytic enzyme in carp plasma; activated by heparin; inhibited by diisopropylfluorophosphate; acts on peptide substrates
carpatamide A: cytotoxic arylamine from a marine-derived streptomyces sp
carpatamide B: cytotoxic arylamine from a marine-derived streptomyces sp
carpatamide C: cytotoxic arylamine from a marine-derived streptomyces sp
carpinontriol A: diarylheptanoid from the stems of carpinus cordata (butulaceae)
carpinontriol B: diarylheptanoid from the stems of carpinus cordata (butulaceae)
carprazidil: vasoactive antihypertensive agent which does not produce tachycardia or water & sodium retention
carriebowlinol: antimicrobial alkaloid from an assemblage of marine cyanobacteria
carriebowmide: isolated from the marine cyanobacterium lyngbya polychroa
carteriosulfonic acid A: gsk-3beta inhibitor from a carteriospongia sp.
carteriosulfonic acid B: gsk-3beta inhibitor from a carteriospongia sp.
carteriosulfonic acid C: gsk-3beta inhibitor from a carteriospongia sp.
carthamine: composed of two chalcones; from carthamus tinctorius; the conjugated bonds cause a red color; derived from precarthamin by a decarboxylase; do not confuse with carthamidin
cartilage-derived morphogenetic protein-3 protein, mouse: a member of the transforming growth factor-beta superfamily; has been sequenced
cartilage-derived-morphogenetic protein-2: a member of the transforming growth factor-beta superfamily; amino acid ; genbank u13661
cartilage-related protein (vitreous body): non-collagenous protein found in bovine & human vitreous body; mw 55,000 & subunits of 130,000 mw; shared cartilage & eye antigen
cartorimine: a cycloheptenone oxide derivative from carthamus tinctoriusfrom
cartregulin, rat: 146-amino acid protein with one putative transmembrane domain; expressed in brain and in some other tissues; an up-regulator of carnitine transporter octn2; has been sequenced
carvacryl acetate: a derivative of carvacrol that reduces nociceptive and inflammatory response in mice
carveol dehydrogenase: catalyzes conversion of carveol to carvone; amino acid ; genbank aj006869
carvone: an oxidized derivative of limonene; rn given refers to cpd without isomeric designation; l-carvone has spearmint flavor, d-carvone has dill/caraway flavor
caryolane-1,6beta-diol: from the fermentation broth of streptomyces sp.
caryolane-1,7alpha-diol: isolated from the fermentation broth of streptomyces sp.
caryolanemagnolol: has neuroregenerative activity; isolated from magnolina obovata
caryophyllene cyclase: catalyzes the cyclization of farnesyl pyrophosphate, probably by intramolecular electrophilic attack by c-1 bearing the pyrophosphate ester on c-11 of the terminal double bond to give a humulyl cation, which undergoes closure to a cyclobutyl intermediate and deprotonation at c-3 methyl to form (-) caryophyllene; mw 57 kda
carzelesin: a cyclopropylpyrroloindole analog of u 73975; longer lasting than u 77779
carzinophilin: antitumor antibiotic produced by streptomyces sahachiroi; rn given refers to cpd with unknown mf
cas protein, Drosophila: encodes a zinc finger protein that shares dna-binding specificity with another pdm repressor: the gap segmentation gene regulator hunchback (hb); refseq nm_079938
casamino acids: acid hydrolyzed casein; all nitrogen in casein converted to amino acids or other cpds of relative chemical simplicity
casbene synthetase: from castor bean (ricinus communis); catalyzes the cyclization of geranylgeranylpyrophosphate to form the macrocyclic diterpene casbene
caseagrewifolin B: cytotoxic; from the leaves of casearia grewiifolia
caseagrewiifolin A: cytotoxic; from the leaves of casearia grewiifolia
caseamembrin M: cytotoxic clerodane diterpenoid from casearia membranacea
caseamembrin N: cytotoxic clerodane diterpenoid from casearia membranacea
caseamembrin O: cytotoxic clerodane diterpenoid from casearia membranacea
casearvestrin A: from the leaves and twigs of casearia sylvestris (flacourtiaceae)
casearvestrin B: from the leaves and twigs of casearia sylvestris (flacourtiaceae)
casearvestrin C: from the leaves and twigs of casearia sylvestris (flacourtiaceae)
caseicin A: corresponds to amino acids 6 to 14 of isracidin
caseicin B: corresponds to amino acids 15 to 22 of isracidin
casein hydrolysate: an ingredient of trypticase soy broth; casitone is a tryptic digest of casein
casein kinase 2 beta (1-16): modulates activity of casein kinase 2
casein, magnesium carbonate, pectin, potassium bicarbonate drug combination: anti-reflux agent; contains pectin, casein, magnesium carbonate & potassium bicarbonate
cashmirol A: lipoxygenase inhibiting triterpene from sorbus cashmiriana
cashmirol B: lipoxygenase inhibiting triterpene from sorbus cashmiriana
casiopeine: cu complex with mf c26-h20-n3-o4-cu; no other info avail 3/92
casirivimab: used in combination with imdevimab against sars-cov-2 virus
casirivimab and imdevimab drug combination: a mixture of anti-sars-cov-2 antibodies
casocidin I: a 39-amino-acid-containing peptide; from bovine milk; amino acid sequence given in first source
casoxin C: ileum-contracting peptide that is a complement 3a receptor agonist
casp protein, Drosophila: a suppressor of antibacterial immunity; drosophila homolog of mammalian faf1; refseq nm_137236
caspase 13: erice - evolutionarily related ice (interleukin-1beta converting enzyme); a flice-activatable caspase; mw 43 kda; amino acid
caspase 9s, human: a caspase 9 variant and dominant inhibitor that lacks the catalytic site
caspase-activated DNase inhibitor: from mouse t-lymphoma, with two forms short (s) & long (l); icad is the mouse homolog of human dff45
caspase-activated deoxyribonuclease: degrades dna during apoptosis, inhibited by icad (inhibitor of cad); a protein of 343 amino acids carrying a nuclear localization signal; amino acid
caspase-independent lethal 56: induces an unconventional form of nonapoptotic cell death
caspicaoside B: cytotoxic compound from fruits of gleditsia caspica
caspicaoside C: cytotoxic compound from fruits of gleditsia caspica
cassiaphenone A-2-glucoside: isolated from cassia angustifolia (leguminosae)
cassiaphenone B-2-glucoside: isolated from cassia angustifolia (leguminosae)
cassigarol A: ; a polyphenol isolated from the heartwood of cassia garrettiana craib
cassiicolin, Corynespora cassiicola: a host-selective protein toxin from corynespora cassiicola; pattial amino acid
cassine: rn given for (2s-(2alpha,5alpha,6alpha))-isomer
cassipourol: cytotoxic diterpene from cassipourea madagascariensis from the madagascar rainforest
cassipouryl acetate: cytotoxic diterpene from cassipourea madagascariensis from the madagascar rainforest
castanospermine: indolizidine alkaloid from seeds of australian legume, castanospermum australe
castasterone: a brassinosteroid; rn refers to ((2alpha,3alpha,5alpha,22r,23r,24s)-isomer
casuarictin: rn given refers to beta-d-glc stereoisomer; rn for cpd without isomeric designation not avail 3/92; precursor of ellagic acid
casuarinin: a hydrolyzable tannin from the bark of terminalia arjuna (combretaceae)
cat-L1B protein, Fasciola gigantica: genbank aaf44675
catM protein, Acinetobacter: 28-kda; encodes an inducer-independent transcriptional activator; previously thought to encode a repressor protein; in the absence of cis,cis-muconate prevents expression of the cat structural genes; amino acid sequence given in first source
catabathmophobin: brain oligopeptide isolated as transfer factor for step-down avoidance
catabolite activator protein, copper-OS26: a high-specificity dna-cleavage agent; the dna-cleaving moiety, copper:o-phenanthroline is attached to the sequence specific cap; amino acid sequence has been determined
catabolite control proteins, bacteria: from a variety of bacterial species; results in the loss of glucose repression of amylase synthesis
cataglykin: fragment derived from growth hormone; rn given refers to cpd with unknown mf
catalase HPI: encodes both catalase and peroxidase activity; necessary for sensitivity to isoniazid; deletion is associated with isoniazid resistance; partial amino acid sequence given in first source; from a wide variety of bacterial species
catalase I: has thermal conversion from low to high activity forms; from bacillus stearothermophilus
catalase-peroxidase, Haloarcula: archeal enzyme; has both catalase (dismutation of h2o2 to o2 and h2o) and peroxidase (uses h2o2 to oxidize other compounds) activity; amino acid ; genbank y16851
catalase-peroxidase, bacteria: has both catalase (dismutation of h2o2 to o2 + h2o) and peroxidase (uses h2o2 to oxidize other cpds) activity; cpeb also has manganese peroxidase activity; from rhodobacter, synechococcus & cyanobacteria; amino acid ; genbank x71420
catalet: a desensitization vaccine containing pollen antigens; c is from weed pollen, d is from tree pollen
catalpol: component of dihuang; rn given refers to (1as-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-isomer; rn for cpd without isomeric designation not avail 12/92
catalytin: an immobilized preparation containing terrilytin and the antiseptic catapol
catch-relaxing peptide (Mytilus): from mytilus pedal ganglia; relaxes catch tension of the anterior byssus retractor muscle
catchin protein, Mytilus galloprovincialis: a protein in molluscan catch muscles; amino acid
catechin 7-O-glucopyranoside: a cytoprotective agent against streptozotocin damage; isolated from ulmus davidiana
catechin-(3'-O-3''')-afzelechin: from the whole plant of periploca aphylla
catechin-(4,8)-malvidin-3-O-glucoside: a red wine pigment
catechin-3-o-rhamnoside: isolated from the stem bark of lannea kerstingii engl. and k. krause (anacardiaceae)
catechol functionalized-chitosan: formed from reaction of chitosan with hydrocaffeic acid; has antibacterial activity towards staphylococcus epidermis when added to wound dressings
catechol oxygenase II: analogous to ec 1.13.11.1 but highly specific for chlorinated substrates & less active toward non-chlorinated substrates
catechol-3,6-bis(methyleneiminodiacetic acid): used in treatment of uranium intoxication
catecholamine-beta-alanyl ligase: in the medfly ceratitis capitata
catecholamine-regulated protein, 40 kDa: detected only in brain in mammals; genbank af047009
catesbeianalectin: polypeptide has a molecular weight of 1.47 kd, making it the smallest known lectin in terms of molecular weight
cathafoline: an akuammiline alkaloid with a methanoquinolizidine core
catharanthine: indole moiety of dimeric vinca alkaloids vinblastine & vincristine; rn given refers to (2alpha,5beta,6alpha,18beta)-isomer
cathedulins: alkaloids from catha edulis with mol wt in 600-1200 range; polyesters or lactones of sesquiterpene polyol core
cathelicidin 2 protein, mammal: ecath-2 isolated from equine leukocytes; amino acid sequence first source; genbank aj224928
cathelicidin 3 protein, Equus caballus: ecath-3 isolated from equine leukocytes; amino acid sequence first source; genbank aj224929
cathelin: amino acid sequence given in first source; an 11-kda protein isolated from porcine leukocytes; a non-inhibitory protein similar to pro-regions of antibacterial peptides
cathepsin J: cysteine proteinase; ph optimum is 6.2-6.8; hydrolyzes cbz-phe-arg-aminomethylcoumarin; mw 230,000
cathepsin L1, Fasciola hepatica: a major cysteine protease of f hepatica; genbank aj312374
cathepsin M: membrane-bound lysosomal enzyme which can inactivate fructose 1,6-bisphosphatase
cathepsin N: acts only on soluble & insoluble collagen; different specificity than cathepsin l & b
cathepsin Q: a lysosomal cysteine protease highly expressed in placenta; amino acid ; genbank af187323
cathepsin S: best substrate may be hemoglobin at ph 3; specificity unknown
cathepsin T: catalyzes conversion of multiple forms of tyrosine aminotransferase (ec 2.6.1.5); glycoprotein of mw 33,500-35,000
cathepsin Y: catalyzes formation of bradykinin potentiating peptide in rat plasma; amino acid
cathepsin-6: a cysteine proteinase showing homology with and co-localized expression with cathepsin j/p in the labyrinthine layer of mouse placenta; amino acid
cathinone: alkaloid from khat shrub, catha edulis; rn given refers to parent cpd without isomeric designation
cation-dependent mannose-6-phosphate receptor: refseq nm_001207024 (m6pr human)
cationic amino acid transporter 2, Arabidopsis: do not confuse with the catalase cat2 protein, arabidopsis
cationic amino acid transporter 3, Arabidopsis: do not confuse with the catalase cat3 protein, arabidopsis
cationic antimicrobial protein 57, human: 57kda cationic protein from human polymorphonuclear leukocytes
cationic colloidal gold: particles of colloidal gold coated with poly-l-lysine; a probe for detection of anionic cell surface sites by electron microscopy
cationic isoperoxidase PC3: a strongly cationic isoperoxidase, purified to homogeneity from scented-geranium (pelargonium graveolens) callus
cationic peptide, CL22: a cationic peptide for efficient transfection of mammalian cells; amino acid
cationic protein, urate-calcium oxalate stone, human: a protein from urate-calcium oxalate stone with 60% homology to cd59 protein (protectin); also excreted in urine; partial amino acid sequence given in first source
cationic staphylococcal protein, 70-kDa: a highly cationic protein that binds immunoglobulin without specific antigen-antibody recognition, induces glomerular injury in rats; isolated from cell surface of staphyloccus aureus
cato protein, Drosophila: a basic helix-loop-helix transcription factor implicated in the correct differentiation of drosophila sense organs; amino acid
catrocollastatin: a snake venom protein from crotalus atrox (western diamondback rattlesnake); inhibits platelet adhesion to collagen; 609 amino acids; amino acid sequence given in first source; genbank u21003
catrocollastatin-C: a 23.6 kda disintegrin-like cysteine-rich two-domain protein from crotalus atrox venom; amino acid sequence given in first source
catroxase: metalloprotease from crotalus atrox venom with alpha- and beta-fibrinogenase activity
catroxobin: thrombin-like enzyme from crotalus atrox; clots fibrinogen very slowly, releasing fibrinopeptide a & a small amount of fibrinopeptide b; amino acid sequence given in first source
cattienoid B: has antineoplastic activity; isolated from tomophagus cattienensis
catumaxomab: used in the treatment of malignant ascites in patients with metastatic cancers; binds epcam and cd3 antigens. extracorporeal pbmnc coating with catumaxomab may be an option to control intravascular cytokine release induced by therapeutic antibodies
caudatin-2,6-dideoxy-3-O-methylcymaropyranoside: has antineoplastic activity; isolated from cynanchum auriculatum
caudatin-3-O-beta-D-cymaropyranosyl-(1-4)-beta-D-cymaropyranosyl-(1-4)-beta-D-cymaropyranoside: antiepileptic from the roots of cynanchum otophyllum
caudatin-3-O-beta-D-cymaropyranosyl-(1-4)-beta-D-digitoxopyranoside: a steroidal glycosides from cynanchum wallichii wight
caudatin-3-O-beta-D-glucopyranosyl-(1-4)-beta-D-cymaropyranosyl-(1-4)-beta-D-oleandropyranosyl-(1-4)-beta-D-cymaropyranosyl-(1-4)-beta-D-digitoxopyranoside: from cynanchum wallichii
caudatin-3-O-beta-D-oleandropyranosyl-(1-4)-beta-D-cymaropyranoside: a steroidal glycosides from cynanchum wallichii wight
caudo dorsal cell-like hormone, leech: a leech egg-laying-like hormone from theromyzon tessulatum; amino acid
caudoxin: neurotoxic phospholipase a2 from horned puff adder
cauleslactone: from the essential oil of the subterranean part of asarum caulescems
cauliflorin: ellagitannin from jabuticaba (myrciaria cauliflora)
caulilexin A: a phytoalexin, active against the economically important pathogenic fungi leptosphaeria maculans, rhizoctonia solani and sclerotinia sclerotiorum; isolated from florets of cauliflower (brassica oleracea var. botrytis)
caulilexin B: a phytoalexin, active against the economically important pathogenic fungi leptosphaeria maculans, rhizoctonia solani and sclerotinia sclerotiorum; isolated from florets of cauliflower (brassica oleracea var. botrytis)
caulilexin C: a phytoalexin, active against the economically important pathogenic fungi leptosphaeria maculans, rhizoctonia solani and sclerotinia sclerotiorum; isolated from florets of cauliflower (brassica oleracea var. botrytis)
caup protein, Drosophila: member of iroquois complex in drosophila; putative positive regulatory protein of achaete-schute genes; genbank x95178
cauxin protein, Felis catus: catalyzes the hydrolysis of 3-mbcg (3-methylbutanol-cysteinylglycine) to yield felinine; secreted in the urine of cats; genbank ab045377
cav protein, Drosophila: required for telomere capping; refseq nm_079753
caveolin-1 (82-101): an endothelial nitric oxide synthase inhibitor
caveolin-1 scaffolding domain peptide CSP7: fttftvt
cavernolide: a c2, terpene lactone isolated from the sponge fasciospongia cavernosa; structure in fisrt source
cavinafungin: isolated from the fungus colispora cavincola, effective on zika and dengue virus
cavitand 4: cavitands are synthetic organic cpds with enforced cavities large enough to complex complementary organic cpds or ions
cavitand 5: cavitands are synthetic organic cpds with enforced cavities large enough to complex complementary organic cpds or ions
cavitand 6: cavitands are synthetic organic cpds with enforced cavities large enough to complex complementary organic cpds or ions
cavitand 7: cavitands are synthetic organic cpds with enforced cavities large enough to complex complementary organic cpds or ions
caylobolide A: a unique 36-membered macrolactone from a bahamian lyngbya majuscula
caylobolide B: from marine cyanobacteria phormidium spp. from florida
caz protein, Drosophila: homologous to c-terminal regions of tls and ews proteins; isolated from drosophila melanogaster; amino acid ; refseq nm_078641
cbbE' protein, Coxiella burnetii: amino acid sequence given in first source
cbdB protein, E coli: cytochrome bd-ii oxidase subunit ii (ec 1.10.3.- ); from e coli; may have cytochrome oxidase activity; amino acid sequence given in first source; homologous appb protein found in other species
cbfA protein, Dictyostelium discoideum: binds the c-module of the dre retrotransposable element; amino acid ; genbank af052006
cbiL protein, Salmonella typhimurium: one of enzymes involved in hydrogenobyrinic acid synthesis; methylates c-20 of precorrin-2 to form precorrin-3; 10 aa amino-terminal sequence given in first source
cblc-1 protein, C elegans: a b12 trafficking protein with glutathione transferase, and aquocobalamin reductase, and reductase decyanase activities; refseq nm_001027353.4
cbp1 protein, S pombe: binds to autonomously replicating sequence elements; genbank u39079; do not confuse with actin-binding protein, abp1p protein
cc-486: oral form of azacitidine, a pyrimidine analogue that inhibits dna methyltransferase impairing dna methylation
ccar-1 protein, C elegans: refseq nm_001268851.1
cce1 protein, S pombe: a holliday (four-way dna) junction-resolving enzyme from schizosaccharomyces pombe; has 28% identity with cce1; amino acid sequence given in first source
ccf-1 protein, C elegans: a subunit of the ccr4-not complex, essential for both somatic and germline development; has been sequenced; refseq nm_067152.6
ccl19a.2 protein, zebrafish: refseq nm_001136248
ccm1 protein, Chlamydomonas reinhardtii: a regulatory gene controlling the induction of a carbon-concentrating mechanism in chlamydomonas reinhardtii by sensing co2 availability; amino acid ; do not confuse with ccm1 gene product that is a methyltransferase
ccnd2-A protein, Xenopus: essential for the control of the cell cycle at the g1/s (start) transition; genbank x83503
ccr protein, Citrus x paradisi: from citrus paradisi; amino acid sequence given in first source; genbank x32632
ccs52 protein, Medicago sativa: required fro endoreduplication and ploidy-dependent cell enlargement in plants; amino acid
ccsA protein, protozoan: amino acid sequence given in first source; an actively transcribed euglena gracilis chloroplast gene homologous to the arabidopsis thaliana nuclear gene cs(ch-42); isolated from chloroplasts of other organisms
cd-HA-lubricin: a conjugate of carbodiimide-derivatized hyaluronic acid and lubricin; used in tendon reconstruction
cdc-14 protein, C elegans: involved in cell cycle regulation of central spindle assembly; genbank af000363; refseq nm_001026798.5
cdc-48.1 protein, C elegans: refseq nm_063872.4
cdc-48.2 protein, C elegans: refseq nm_063304.5
cdc16 protein, S pombe: required both for maintenance of p34(cdc2) kinase activity & regulation of septum formation
cdc18 protein, S pombe: from yeast; plays essential roles in the mechanisms that control entry into s phase & coordinates s phase with mitosis; amino acid sequence given in first source; genbank l16793
cdc2 protein, S pombe: from s pombe; not related to cdc2 protein, s cerevisiae
cdc2(6-20)NH2: amino acid sequence given in first source; derived from p34cdc2; substrate of src-family tyrosine kinase
cdc22 protein, S pombe: amino acid sequence is highly similar to the large subunit of ribonucleotide reductase; 811 amino acid residues, mw 92.2 kda; amino acid sequence given in first source
cdc2E2 protein, rat: enhancer and silencer binding protein involved in the rat cdc promoter activation at the g1/s boundary; amino acid
cdc2c protein, Arabidopsis: isolated from arabidopsis thaliana; amino acid ; genbank u83118 and af120153
cdc2rk protein, Drosophila: isolated from drosophila; amino acid ; genbank d16402
cdc31 protein, S pombe: a small, acidic protein of 161 aa with a striking homology to calmodulin and caltractin; a component of the half bridge of the spindle pole body; has been sequenced
cdc42ep1 protein, Xenopus: refseq xm_018258895.1
cdc6 protein, S pombe: putative dna polymerase; don't confuse with cdc2 kinase
cdcA protein, Pyrococcus kodakaraensis: encodes a cell division control protein from the hyperthermophilic archaeon pyrococcus kodakaraensis; amino acid
cdca9 protein, Xenopus: a component of the chromosomal passenger complex; genbank ay644400
cdf-1 protein, C elegans: is a cation diffusion facilitator protein that is structurally and functionally similar to vertebrate znt-1; amino acid
cdi protein, Drosophila: involved in drosophila central nervous system midline cell development; ortholog of human testis-specific testk1 protein kinase; amino acid ; genbank af139811-2
cdk-1 protein, C elegans: cell division control protein 2 homolog; encodes a cdc2-related kinase required for m phase in meiotic and mitotic cell divisions, but not for s phase; amino acid ; genbank af129109; refseq nm_001027576.3
cdkB2 protein, Solanum lycopersicum: a c-type cyclin-dependent protein kinase isolated from tomato; genbank aj297917; refseq nm_001246976
cdl-1 protein, C elegans: amino acid ; refseq nm_063919.7
cdm protein, Drosophila: has been sequenced; refseq nm_142425
cdpgs protein, Methanothermus fervidus: catalyzes the conversion of 2,3-diphosphoglycerate & atp to cyclic 2,3-diphosphoglycerate & adp & pi in the presence of mg+
cdr1 protein, S pombe: dual function protein kinase which autophosphorylates serine and tyrosine residues; acts as negative regulator of mitosis by down-regulating the wee1 protein kinase pathway in yeast; has been sequenced; nim1 is also known as cdr1; do not confuse with cdr1 protein(s); genbank x57549 and m16509
cdt1 protein, S pombe: required for licensing dna for replication; amino acid
cecropic acid: ursane type; from musanga cecropiodes (cecropiaceae)
cecropin 1 protein, medfly: from ceratitis capitata; amino acid sequence given in first source; genbank x70030
cecropin A: from cecropia moth, hyalophora cecropia; small basic protein; has potent antibacterial activity against e coli & other gram-negative bacteria; ; also prevents development of malarial oocysts in mosquito vector
cecropin A(1-7)-melittin(2-12)-Tat(47-57) peptide: a hybrid cell-penetrating peptide for gene delivery
cecropin B protein, Insecta: from cecropia moth, hyalophora cecropia; small basic protein; has potent antibacterial activity against e coli & other gram-negative bacteria; also found in a variety of other insects; ; also prevents development of malarial oocysts in mosquito vector
cecropin B1 protein, insect: a synthesized antibacterial peptide; designed as an analog to the natural insect antibacterial peptide, cecropin b; involved in membrane lysis; amino acid
cecropin B3 protein, insect: a synthesized antibacterial protein; designed as an analog to the natural insect antibacterial peptide, cecropin b; amino acid
cecropin CMIV protein, Bombyx mori: isolated from the chinese silkworm moth; appears to have been sequenced
cecropin D protein, Hyalophora cecropia: from cecropia moth, hyalophora cecropia; small basic protein; amino acid sequence given in first source; affective against several gram-positive & gram-negative bacteria
cecropin P1-LI: antibacterial peptide isolated from porcine intestine; has immunoreactivity in epithelial cells of duodenum & glucagon cells of the pancreas
cecropin protein, Anopheles: from the malaria vector mosquito, anopheles gambiae; amino acid ; genbank af200686
cecropin-2 protein, Ceratitis capitata: from ceratitis capitata; amino acid sequence given in first source; genbank x70029
ced-1 protein, C elegans: mediates cell corpse engulfment in c. elegans; amino acid
ced1 protein, Butyrivibrio fibrisolvens: shows cellodextrinase activity & rapidly hydrolyzes short-chain cellodextrins to yield either cellobiose or cellobiose & glucose as end products; releases cellobiose from p-nitrophenyl-beta-d-cellobioside & is not inhibited by methyl cellulose; amino acid sequence given in first source; from butyrivibrio fibrisolvens h17c
cedarwood oil: obtained by steam distillataion or solvent extraction of cedrus or juniperus; contains cedrol and cedrene
cediranib: vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor
cedrelanolide: a limonoid with plant-growth inhibitory activity from cedrela salvadorensis
cedrodorol A: protein tyrosine phosphatase 1b inhibitor from cedrela odorata
cedrodorol B: protein tyrosine phosphatase 1b inhibitor from cedrela odorata
cedrol: a cyclic terpenoid from cedarwood oil; 8-epicedrol is an epimer
cedronin: a quassinoid with a c19 basic skeleton; isolated from simaba cedron
cefbuperazone: rn given refers to parent cpd(6r-(6alpha,7alpha,7(2r*,3s*)))-isomer
cefditoren: ; rn given refers to the (6r-(3(z),6alpha,7beta(z)))-isomer
cefditoren pivoxil: ; me 1207 is the pivaloyloxymethyl ester of me 1206
cefquinome: broad spectrum antibiotic; rn given refers to (6r(6alpha,7beta(z)-isomer)
ceftobiprole: bal5788 is ceftobiprole medocaril sodium
ceftolozane: cephalosporin anti-bacterial agent with enhanced activity against pseudomonas aeruginosa
cefuroxime axetil esterase: catalyzes the hydrolysis of cefuroxime axetil to cefuroxime; also acts (slowly) on p-nitrophenyl acetate & alpha-naphthyl acetate
ceh-10 protein, C elegans: from caenorhabditis elegans; closely related to mice chx10 and goldfish vsx-1; genbank u19995
ceh-19 protein, C elegans: homeobox protein; its gene is located between lin-45 & unc-24 on chromosome iv; amino acid sequence given in first source
ceh-20 protein, C elegans: member of the hox family of homeoproteins and plays a central role in pattern formation of all germ layers; homolog of drosophila extradenticle (exd); has been sequenced; genbank u01303
ceh-32 protein, C elegans: a six/sine oculis class homeobox gene product required for head morphogenesis; genbank af325178
ceh-36 protein, C elegans: encodes a putative homemodomain transcription factor involved in chemosensory functions of ase and awc neurons; amino acid
ceh-43 protein, C elegans: the caenorhabditis elegans distal-less ortholog is required for development of the anterior hypodermis; plays a role in cell adhesion; amino acid
cek1 protein, S pombe: may play a role in anaphase; isolated from schizosaccharomyces cerevisiae; amino acid ; genbank d31773 (cek1+); do not confuse with cek1 protein
cel-3 protein, Fibrobacter succinogenes: isolated from fibrobacter succinogenes s85; exhibits both endoglucanase & cellobiosidase activites; genbank m29047
cel5Z protein, Erwinia chrysanthemi: isolated from pectobacterium chrysanthemi
cel9A protein, Pseudomonas: a carboxymethyl-cellulase from marine pseudomonas sp. sk38; genbank af296443
celC protein, bacteria: amino acid sequence given in first source; a phospho-beta-glucosidase
celD protein, Bacteria: amino acid sequence given in first source; encodes pts enzyme iii; do not confuse with endoglucanase celd
celG protein, Bacteria: acts as a typical endoglucanase, causing a steep decrease in viscosity while liberating a low amount of reducing sugars; 51.5% identical to endoglucanase celb, both from clostridium thermocellum; 566 aa residues, mw 63,128 da; aa sequence given in first source; genbank x69390
celahin D: an agarofuran sesquiterpene polyol ester from celastrus hindsii
celangulatin G: has insecticidal activity; isolated from celastrus angulatus
celangulatin H: has insecticidal activity; isolated from celastrus angulatus
celangulatin I: has insecticidal activity; isolated from celastrus angulatus
celaphanol A: isolated from the roots of celastrus orbiculatus (celastraceae)
celastramycin A: has anti-infective activity; isolated from streptomyces
celastrol: isolated from tripterygium wilfordii; potent inhibitory activity on both kir2.1 and erg1 potassium channels, leading to long qt syndrome
celastrol methyl ester: isolated from tripterygium wilfordii; potent inhibitory activity on both kir2.1 and erg1 potassium channels, leading to long qt syndrome
celebeside A: an anti-hiv agent isolated from the indian sponge siliquariaspongia mirabilis
celebeside B: an anti-hiv agent isolated from the indian sponge siliquariaspongia mirabilis
celecoxib-NBD: a fluorescent cyclooxygenase-2 inhibitor
celesticetin A: antibiotic produced by streptomyces caelestis from soil; active against gram positive & plant pathogens
cell aggregation factors: species-specific cell aggregation factor sometimes from porifera; proteoglycan from sponge species; see also record for acrasin
cell cohesion molecule, Dictyostelium: 80 kda surface glycoprotein; involved in cell-cell contact; a conditioned medium factor; amino acid sequence has been determined
cell differentiation agent II: a mixture product from healthy male human urine containing peptides, organic acids & phenylacetate; may be an anticancer agent; enhances gsh peroxidase activity; has free radical scavenger activity
cell differentiation factor 8.2-kDa: human leukemia differentiation factor; isolated from leukemia cells hl-60; amino acid ; genbank x79563
cell wall polysaccharide, Actinoplanes: carbohydrate sequence given in first source; isolated from actinoplanes; 153689-93-1 (registry number of the 2 sugar repeating unit)
cell wall polysaccharide, Streptococcus: carbohydrate sequence given in first source
cell-binding immunoglobulin-like protein, human: mw greater than 900k; protein from human plasma with several disulfide-linked subunits, one identical to heavy chain of igm, one to heavy chain of igg & one related immunologically to heavy chain of iga
cell-binding peptide P-15: synthetic peptide analog of collagen; sequence of alpha1(i) chain 766-780
cell-elongating factor, Vibrio cholerae: causes elongation of chinese hamster ovary (cho) cells; amino acid
cell-surface retention-binding protein 1: from bovine liver plasma membranes; has been sequenced
cell-to-cell transport protein, odontoglossum ringspot virus: amino acid sequence given in first source
cellobionic acid: rn given refers to (beta-d-glucopyranosyl cpd)
cellobiose 2-epimerase, Ruminococcus albus: genbank ab301953
cellobiose phosphotransferase B: amino acid sequence given in first source; encodes pts enzyme ii, together with cela; do not confuse with celb endoglucanase
cellobiosidase: cleaves the penultimate glucosidic linkage of p-nitrophenyl-beta-d-cellobioside
celloconingine P10x: enzyme complex of proteolytic & amylolytic activity
cellodextrin phosphorylase: reverse reaction is used to synthesize cellodextrins
cellryl: reticuloendothelium or cell respiration activating substance extracted from bovine blood; used in therapy of peptic ulcer & cerebrovascular disorders
cellular Nip1: nip - 19 kda interacting protein; a cellular protein involved in prevention of cell death; amino acid sequence given in first source; genbank u15172; do not confuse with nip1, a fungal protein
cellulose acetate esterase: isolated from neisseria sicca; n-terminal amino acid
cellulose binding protein A, Clostridium cellulovorans: amino acid sequence given in first source; 189036 da scaffoldin protein; forms complex called cellulosome with beta-glucanase activity to degrade cellulose; if not present, only soluble substrates will be degraded
cellulose synthase: cellulose synthases represent a group of beta-1,4 glycosyltransferases involved in cellulose biosynthesis; from populus tremuloides (quaking aspen); genbank ay055724
cellulose synthase (cyclic diguanylic acid): plant enzyme; activated by cyclic diguanylic acid; uses udpglucose as substrate
cellulose-binding protein p40, Streptomyces halstedi: genbank u51222
cellulosome, Clostridium: cellulolytic enzyme complex (cellulosome) of clostridium sp
celogentin A: an antimitotic bicyclic peptide from the seeds of celosia argentea
celogentin B: an antimitotic bicyclic peptide from the seeds of celosia argentea
celogentin C: an antimitotic bicyclic peptide from the seeds of celosia argentea
celosian: an acidic polysaccharide from seeds of celosia argentea; has protective effect on chemically and immunologically induced liver injuries
celosin A: from seeds of celosia, has protective effects against ccl4-induced hepatotoxicity
celosin B: from seeds of celosia, has protective effects against ccl4-induced hepatotoxicity
celsr1a protein, zebrafish: promotes extension of the entire antero-posterior axis of the zebrafish gastrula including prechordal plate and ventral diencephalic precursors
celsr1b protein, zebrafish: cooperates with fmi1a to regulate convergence and extension during embryogenesis
celtisine: has relaxant action in uterine smooth muscle; rn from toxlit
cemadotin: a synthetic derivative of dolostatin 15; interacts with microtubules & inhibits mitosis
cembra-2,7,11-triene-4,6-diol: isolated from tobacco
cembrane: diterpene with ca-antagonistic action on rabbit aorta from soft coral of genus sarcophyton
cembrene A: rn refers to (r-(e,e,e))-isomer; isolated from paracloacal glands of the chinese alligator (alligator sinensis)
cementoin: a peptide of 35 amino acid residues; a transglutaminase-mediated anchoring sequence in elafin; rich in gln and lys residues; amino acid sequence given in first source
cementum attachment protein, 55-kDa: bind specifically to mineralized dentin and synthetic hydroxyapatite but not to demineralized dentin; amino acid sequence known