NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
tpr protease: membrane-associated, thiol-dependent protease; amino acid ; genbank af022499
tra-2 protein, C elegans: tra-2 - transformer-2; a sex-determining gene product; amino acid sequence given in first source
traB protein, Bacteria: transfer protein b; from traabcd region of inci1 plasmid r64; amino acid sequence given in first source; from several species
traC protein, Plasmid F: has been sequenced; plays a role in assembly of pilin subunits into an extended pilus filament
traD protein, E coli: trad is a cell envelope protein; the function of trad is unknown but it is essential for dna transfer; it may form or may be part of a non-specific pore for dna export, or it may directly energizes dna transport; amino acid sequence given in first source; do not confuse with trad protein
traK protein, E coli: plays an accessory role in the initiation of transfer dna replication; amino acid sequence has been determined
traN protein, E coli: amino acid sequence given in first source; believed to be required for formation of stable mating aggregation during f-directed conjugation; isolated from e coli
traW protein, E coli: amino acid sequence given in first source; 210 amino acid residues; 23,610 da polypeptide from e. coli; involved in f-pilus assembly and is required for plasmid conjugative transfer
traY protein, E coli: from factor f of e coli; binds to orit; amino acid sequence has been determined
trabecular meshwork-induced glucocorticoid response protein: encodes a trabecular meshwork protein; causes primary open angle glaucoma; amino acid sequence known; genbank r95491; refseq nm_000261 (human), nm_010865 (mouse), nm_030865 (rat)
trace amine receptor 4, human: is preferentially expressed in those brain regions that have been implicated in the pathophysiology of schizophrenia
tracheal antimicrobial peptide, bovine: from bovine tracheal mucosa; contains 38-amino acid residues; cysteine-rich peptide with antimicrobial activity; amino acid sequence given in first source
tracheal colonization factor, Bordetella pertussis: isolated from bordetella pertussis; amino acid ; genbank u16754
tracheal cytotoxin, Bordetella pertussis: rn & ; a disaccharide-tetrapeptide derivative of the cell wall peptidoglycan layer; attaches to ciliated epithelial cells resulting in their destruction
tracheary element differentiation inhibitory factor, Arabidopsis: secreted by the phloem; prevents differentiation of vascular cells into xylem cells
tracheloside: a lignan isolated from the seeds of arctium lappa and carthamus tinctorius
trachycladindole C: isolated from trachycladus laevispirulifer
trachyloban-19-oic acid: from sunflower helianthus annuus l.; rn given refers to (4r,4as,6as,7ar,8s,8ar,9ar,9bs)-isomer
trachynilysin: a haemolytic protein toxin; isolated from stonefish synanceia trachynis; amino acid composition given in first source; has been sequenced
trachyspic acid: isolated from talaromyces trachyspermus; inhibits heparanase
tracizoline: rn given for (r-(r*,r*))-2,3-dihydroxybutanedionate (1:1); ligand for imidazoline receptor
tradamixina: for treatment of reduced libido; consists of above cpds plus alga ecklonia bicyclis, and tribulus terrestris
tradamixina plus Serenoa Repens: for treatment of lower urinary tract symptoms; consists of above cpds plus alga ecklonia bicyclis, tribulus terrestris, and serenoa repens
traheal cytotoxin, E coli: a naturally occurring fragment of gram-negative peptidoglycan that is a potent elicitor of innate immune responses
tralokinumab: a potent and selective il-13-neutralizing igg4 mab
tralomethrin: rn given refers to cpd with unspecified isomeric designation
trametinib: inchikey: liryphyghxzjbz-uhfffaoysa-n
trandolaprilat: rn given refers to cpd without isomeric designation; rn 87679-71-8 refers to trandolaprilat
tranilast: antiallergic drug; potent inhibitor of homologous passive cutaneous anaphylaxis
trans 3,4-cyclopropyl L-arginine: isoform selective inhibitors of nitric oxide synthase
trans-(3)E-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-4-(hydroxymethyl)dihydrofuran-2(3H)-one: from morinda citrifolia (noni), has insulin mimetic activity
trans-(PtCl2(NH3)(thiazole)): an antitumor agent
trans-(Ru(NO)(NH(3))(4)(POEt)(3))(PF(6))(3): a vasodilator
trans-(dichloroamminethiazole)platinum(II): antineoplastic agent and cross-linking reagent
trans-(tetrahydro-2-(4-hydroxy-3-methoxyphenyl)-5-oxofuran-3-yl)methyl benzoate: isolated from the resin of styrax tonkinensis
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase: rat liver cytosol enzyme also catalyzes 3alpha-hydroxysteroid dehydrogenase activity (ec 1.1.1.50); genbank ah009074 (rat); refseq nm_001818 (human)
trans-1-acetyl-4-phenylcyclohexanol: a non-steroid compound with progestin-like activity
trans-1-chloro-3,3,3-trifluoropropene: a foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion
trans-10,17-octadecadiene-12,14-diyne-1,9,16-triol: from the leaves of bupleurum fruticosum; inhibit the replication of human rhinovirus serotypes 14 and 39
trans-2',6'-dihydroxy-4'-O-(4'-acetyl-rhamnoside)-4-methoxychalcone: ; from trigonosciadium brachytaenium
trans-2,2',4,4'-tetramethyl-6,6'-dinitroazobenzene: from the leaves of aconitum sungpanense
trans-2,3',4,5'-tetrahydroxystilbene: hydroxystilbene oxyresveratrol
trans-2-dodecenal: anthelmintic from eryngium foetidum
trans-2-enoyl-CoA reductase (NADPH): catalyzes the conversion of trans-2-enoyl-(acp/coa) to acyl-(acp/coa) with concomitant oxidation of nadph; refseq nm_017209 (mecr)
trans-2-ethyl-5-((Z)-tridec-4-enyl)pyrrolidine: venom alkaloid of the australian monomorium rothsteini
trans-2-hydroxybenzylidenepyruvate hydratase-aldolase: catalyzes the hydration of cis-o-hydroxybenzylidenepyruvate with subsequent cleavage to form salicylaldehyde--important steps in the bacterial degradation of naphthalene to salicylate
trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene: a naturally occurring resveratrol analog from the bark of yucca schidigera; antioxidant
trans-3,3'-dihydroxy-1,5,1',5'-tetrathiacyclodecane: from the mangrove bruguiera gymnorrhiza
trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene: from pholidota yunnanensis
trans-3,4'-dimethyl-3-hydroxyflavanone: a hair growth enhancing active component, decreases active transforming growth factor beta2 (tgf-beta2) through control of urokinase-type plasminogen activator (upa) on the surface of keratinocytes
trans-3-chloroacrylic acid dehalogenase: specific for conversion of trans-3-chloroacrylic acid to muconic semialdehyde (3-oxopropionic acid); 34 amino-terminal amino acid sequence, with 3 questionable aas, given in first source
trans-3-hydroxyhispidin: luminescence substrate for the bioluminescent mycelia of neonothopanus nambi and n. gardneri
trans-3-methyl-2-hexenoic acid: schizophrenic odor factor
trans-4',5'-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-2)-(alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside): angiogenesis inhibitor from boswellia papyriferai
trans-4',5-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-2)-alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside: stilbene glycoside that exhibited significant inhibition of phosphodiesterase i and xanthine oxidase from boswellia papyrifera
trans-4',5-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside: stilbene glycoside that exhibited significant inhibition of phosphodiesterase i and xanthine oxidase from boswellia papyrifera
trans-4-((1'E,5'S)-5'-carboxy-1'-methyl-1'-hexenyl)cyclohexanecarboxylic acid: a specific inhibitor of human dna polymerase lambda from a fungus of hymenochaetaceae sp.
trans-4-(6,7-dimethoxyquinoxalin-2ylamino)cyclohexanol sulfate: antineoplastic, inhibits pdgf receptor phosphorylation
trans-4-coumaroyl esterase: from bacterial and fungal cultures; cleaves coumaric acid from plant cell wall polysaccharides; see also record for feruloyl-4-coumaroyl esterase
trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one: isolated from the plant vitex cymosa berter
trans-4-methoxy-2-beta-D-glucopyranosyloxycinnamic acid: anti-inflammatory, molluscicidal and free-radical scavenging compound from the leaves of ficus radicans 'variegata' (moraceae)
trans-4-phenylcyclohexylamine: rn given refers to (trans)-isomer
trans-5-(3-methyloxiranyl)pyridincarboxylic acid methyl ester: isolated from submerged cultures of the basidiomycete caripia montagnei.
trans-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo(2,1-a)isoquinoline: a triple monoamine uptake inhibitor
trans-DO2A2P: a bone-seeking agent; ; cis-do2a2p is the geometric isomer with similar activity
trans-activation responsive RNA-binding protein: prbp is 93% identical to trbp; prbp is the murine homolog of trbp; amino acid sequence given in first source; activates the hiv-1 ltr; do not confuse with trbp gene product
trans-alpha-necrodyl isobutyrate: from the grape mealybug pseudococcus maritimus
trans-avicennol: from zanthoxylum chiloperone var. angustifolium
trans-bis-(2,3,4-trihydroxybenzaldoximato)copper(II): an anti-hiv agent
trans-caffeoyl-6-O-D-gluconic acid methyl ester: from the nearly ripe fruits of evodia rutaecarpa:
trans-caffeoylgluconic acid: from the nearly ripe fruits of evodia rutaecarpa
trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2tc-NH2: a selective activator of par2 receptor; derived from par2
trans-cis-cis-(RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2): a strong inhibitor of cathepsin b
trans-dimer D, Axinyssa variabilis: from the south china sea sponge axinyssa variabilis
trans-feruloylgluconic acid: from the nearly ripe fruits of evodia rutaecarpa
trans-hexaprenyltranstransferase: catalyzes reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate to diphosphate + all-trans-heptaprenyl diphosphate
trans-octaprenyltranstransferase: level of isopentenyl diphosphate-magnesium(ipp-mg) is decisive in affecting the chain length of the products of prenyltransferase reaction
trans-pentaprenyltranstransferase: from micrococcus luteus b-p26; composed of 2 components; requires all-trans farnesyl or all-trans-geranylgeranyl pyrophosphate
trans-retinol dehydrogenase: oxidizes all-trans-retinol and 13-cis-retinol to the corresponding aldehydes; oxidizes the 3alpha-hydroxysteroids androstanediol and androsterone to dihydrotestosterone and and androstanedione, respectively
trans-sialidase: transfers alpha(2-3)-linked sialic acid from extrinsic host-derived macromolecules to parasite surfaced molecules leading to the assembly of ssp-3, a trypomastigote-specific epitope; amino acid sequence of sapa antigen given in second source
trans-sodium crocetinate: vitamin a-analog that increases diffusivity of oxygen in aqueous solutions, including plasma
trans-thujane-1alpha,7-diol 1-O-beta-D-glucopyranoside: from siparuna thecaphora
transactivator protein p38(tax): encoded by bovine leukemia virus; activates heterologous promoters with a common sequence known as the camp-responsive element or the binding site of a cellular transcription factor atf
transamidases: substrate cadaverine may be replaced by putrescine as appr; incorporates putrescine and cadaverine into epidermal tissue during keratinization; forms epsilon-(gamma-glutamyl)lysine cross links; transglutaminases are specific transamidases
transcription activator protein C1, Enterobacteria phage P22: mw 10 kda; tetrameric protein composed of 4 identical subunits; regulates transcription of two phage promoters p(re) & p(a23); amino acid sequence given in first source
transcription factor B, Archaea: homologous to tfiib; from various species of archaea such as sulfolobus shibatae; amino acid
transcription factor BM1P2, Bacillus megaterium: from bacillus megaterium; 88 amino acid residues; nucleotide sequence given in first source
transcription factor BTF3: can form stable complex with rna polymerase ii; amino acid sequence given in first source
transcription factor Brn-2: a cns-specific pou transcription factor which is required for establishing mammalian neural cell lineages; amino acid sequence has been determined; refseq nm_005604 (human)
transcription factor E75, Manduca: isolated from tobacco hornworm, manduca sexta; homolog of drosophila melanogaster transcription factor e75; genbank u73683
transcription factor Hed: hed - hlh transcription factor expressed in mammalian embryo & deciduum; 216 amino acids; partial amino acid sequence given in first source
transcription factor NF-AT c3: modulating t cell receptor responsiveness and regulating subsequent cell division and t(h)2 differentiation; has been sequenced
transcription factor NF-E4, human: involved in globin gene switching; genbank ac073127
transcription factor NF-M: amino acid ; do not confuse with neurofilament proteins
transcription factor PEA3: participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester; amino acid sequence (genes dev 1992;6(3):481-96)
transcription factor PTF1: contains two different subunits that interact with dna; plays key role in pancreas-specific gene expression; refseq nm_178161 (ptf1a, human); nm_053964 (ptf1a, rat); nm_018809 (ptf1a, mouse)
transcription factor S-II: protein originally purified from ehrlich ascites tumor cells that stimulated the activity of rna polymerase ii, since then isolated from various organisms; stimulatory factor in nuclear rna synthesis; s-ii' has same primary structure but it is more extensively phosphorylated cells
transcription factor TFIIE: required for transcription initiation by rna polymerase ii; tfiie-34 is tfiie beta
transcription factor TFIIF: rna polymerase ii-associating protein 30 is an essential component; rap30 is the beta sub-unit of the tfiif complex; refseq nm_004128 (gtf2f2, human), nm_031042 (gtf2f2, rat)
transcription factor TFIIG: essential for transcription in the absence of tfiia; involved in the formation of a functional preinitiation complex that is resistant to heparin; not required for template commitment
transcription factor TFIIIE, S cerevisiae: involved in the utilization of stable transcription complexes; its action is not restricted to reinitiation events; has been sequenced
transcription factor TFIIIR, Bombyx mori: tfiiir activity is highly specific to silkworm isoleucine transfer rna; has been sequenced
transcription factor TFIIX: increases rate at which transcripts are elongated by rna polymerse ii & decreases the block to elongation at the ad 2 ml intrinsic termination site; has been sequenced
transcription factor TZP, mouse: involved in oocyte maturation; genbank ak033017
transcription factor XF1, human: binds to xre1, a xenobiotic response element located upstream of the cyp1a1 gene; sequence known
transcription factor XMI-ER1, Xenopus laevis: xmi-er1 is a fibroblast growth factor regulated immediate-early gene that is activated during mesoderm induction in xenopus embryonic explants; amino acid sequence known
transcription factor nuclear factor 1: modulates liver-specific transcription by interactions with hepatocyte nuclear factor 3 & the eh site which is a segment of the liver-specific enhancer of the serum albumin gene; amino acid sequence has been determined
transcription factor tau: involved in primary step of trna synthesis & forms stable complex with trna; transcription factor tau refers to subunits of the dna polymerase iii holoenzyme and has been described in e coli and s cerevisiae; it should not be confused with the microtubule associated tau protein involved in alzheimer's disease or with the e coli proteins involved in taurine metabolism
transcription initiation factor IIA subunit 2, Arabidopsis: refseq nm_118577
transcription initiation factor TIF-IB: a complex of transcription factors that promotes efficient & accurate transcription initiation by rna polymerase i
transcription repression factor ET, Xenopus: a tbox (tbx) protein isolated from xenopus; amino acid ; genbank af173940
transcriptional activator TSRF1, tobacco: research reveals that transcriptional activator tsrf1 reversely regulates plant pathogen resistance and osmotic stress response
transcriptional intermediary factor 1: a mediator of ligand-dependent activation function (af-2); amino acid sequence given in first source
transcriptional intermediary factor 1gamma, zebrafish: the zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis; has been sequenced
transducin GTP phosphohydrolase: stimulated by bovine rhodopsin mutants (asp63 to asn) & (glu134 to gln) with slightly lowered efficiency
transfecting peptide I: contains 20 n-terminal residues of adenovirus fiber protein (ad3) followed by 20 lysines (plys); 20 n-terminal amino acid
transfer region protein, Staphylococcus: from transfer region (tra) of staphylococcal conjugative plasmid psk41; amino acid sequence of tra region (containing tra a-m) in first source; genbank l19570
transferangiotensin: plasma protein component with apparent mw of 700,000 which increases angiotensin ii binding by macromolecules in arterial wall extracts; prealbumin fraction whose activity is increased in some types of essential hypertension
transferrin Shaw protein, human: genetic variant of human transferrin; ile replaced by asp at either position 378 or 381
transferrin-PE40: composed of human transferrin linked by a thioether bond to a truncated portion of pseudomonas exotoxin
transferrin-diphtheria toxin conjugate: hybrid toxin of covalently coupled diphtheria toxin to transferrin
transferrin-ethidium homodimer conjugate: efficient carrier molecule for introduction of genes into eucariotic cells
transferrin-neocarzinostatin conjugate: human serum transferrin conjugated to neocarzinostatin, by using n-succinimidyll-3-(2-pyridylthio)propionate
transformation-transcription domain-associated protein: oncoprotein cofactor essential for c-myc and e2f;transformation/transcription domain-associated protein; genbank af076974
transforming growth factor alpha-Pseudomonas exotoxin A (40): tgf-alpha fused to amino acids 253-613 of pseudomonas exotoxin a; has antitumor effect on human glioblastoma multiforme cells
transforming growth factor beta1.2: heterodimer of tgf-beta1 and tgf-beta2; j biol chem 1992 feb 5;267(4):2325-8
transforming growth factor beta2.3: heterodimer of tgf-beta2 and tgf-beta3; j biol chem 1992 feb 5;267(4):2325-8
transforming growth factor type alpha-Pseudomonas exotoxin A: expressed in e coli & isolated from the periplasm or inclusion bodies; extremely cytotoxic in cells displaying epidermal growth factor receptors & a variety of cancer cell lines
transforming growth factor type e: found in normal and neoplastic tissues of mostly epithelial origin, plasma, and platelets; stimulates both anchorage-dependent & independent growth of epithelial & fibroblast cells of nonneoplastic origin; amino acid sequence has been determined
transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38): a recombinant chimeric molecule composed of tgf-alpha, an epidermal growth factor receptor ligand and genetically engineered form p. aeruginosa exotoxin pe38kdel; a targeted toxin for treatment of malignant glioma
transforming growth factor(alpha)-Pseudomonas exotoxin A (35): a recombinant form of pseudomonas exotoxin a containing tgfalpha near its carboxyl terminus for the treatment of bladder cancer; contains a modified carboxyl-terminal sequence kdel which increases the toxin activity by 10 to 700 fold more potent than tp40 (tgfalpha-pe40)
transframe polypeptide, human: located at the n terminus of pr, can facilitate the dimerization of this variant pr. can help to compensate for folding and/or dimerization defects in pr arising from certain mutations within the pr coding sequence and might therefore function to buffer genetic variations in pr
transgelin: 22-kda protein from fibroblasts & smooth muscle; has several isoforms, sm22 alpha is a major isoform; refseq nm_001001522 (tagln, human); nm_031549 (tagln, rat)
transglutaminase 1: transglutaminase 1 (tgm1 or tgk) is a membrane-associated enzyme involved in the formation of the cornified cell envelope of the epidermis; mutations in the human gene (14q11) cause autosomal recessive lamellar ichthyosis; distinguish from gamma-glutamyltranspeptidase involved with glutathione metabolism and other protein cross-linking transglutaminase; refseq nm_019984 (mouse), nm_031659 (rat), nm_000359 (human)
transglutaminase 4: transglutaminase 4 (tgm4 or tgp) is an extracellular prostate transglutaminase coded by human gene 3p22-p21.33. it suppresses immune response to sperm cells in the female genital tract. distinguish from gamma-glutamyltranspeptidase that is involved with glutathione metabolism
transglutaminase 5: transglutaminase 5 (tgm5 or tgx) is an 81 kda protein in human keratinocytes. distinguish from gamma-glutamyltranspeptidase that is involved with glutathione metabolism
transglutaminase NI: a 29 kda transglutaminases enzyme localized in the brain tissues but not in the liver. requires 100 microm calcium for optimum activity
transglutaminase NII: a 29 kda transglutaminases enzyme localized in the brain tissues but not in the liver. requires 10 microm calcium for optimum activity
translocating chain-associating membrane protein (TRAM): refseq nm_014294
transmembrane envelope glycoprotein gp45, retrovirus: amino acid sequence given in first source
transmembrane glycoprotein, Ebola virus: produced during infection and incorporated into virion; interacts with endothelial cells; secreted and transmembrane forms arise from rna editing; base
transmembrane protein 34, human: tmem34 might be a tumor suppressor gene, associated with the development of ansaplastic thyroid cancer from differentiated thyroid cancers; refseq nm_018241.1; np_060711.1
transmembrane protein, Simian immunodeficiency virus: a transmembrane glycoprotein; from sivmac (simian immunodeficiency virus macaques) and sivagm (simian immunodeficiency virus african green monkey): has been sequenced
transmission-Blocking Vaccine based on Pfs25: a malaria transmission-blocking vaccine candidate antigen produced in recombinant yeast; based on the predominant 25-kda cysteine-rich surface protein of plasmodium (pfs25) with a histidine tag
transplantation antigen P91A, mouse: has homology to drosophila diphenol oxidase a2; amino acid sequence has been determined
transport protein particle, TRAPP: a multiprotein complex containing ten subunits (bet5p, trs20p, bet3p, trs23p, trs33p, trs31p, trs65p, trs85p, trs120p and trs130p); plays a key role in the late stages of endoplasmic reticulum to golgi traffic; amino acid sequence of subunits in first source
transport-capsid assembly protein, Human herpesvirus 6: amino acid sequence given in first source; genbank accession no. l20954
transportan: a galparan (c107160) analog, useful as a carrier vector for hydrophilic molecule, therefore named transportan; amino acid sequence known
transportan-10: a synthetic transportan analog in which six n-terminal residues have been deleted
transporter peptide HGH6: a cys-flanked, internally spaced arg-rich 25 amino acid residue synthetic peptide
transportin SR: import receptor for arginine/serine-rich proteins; amino acid ; genbank af145029
transsylvanoside A: a triterpene glycoside from cephalaria transsylvanica
transsylvanoside B: isolated from the dried flowers of cephalaria transsylvanica
transsylvanoside G: a triterpenoid saponin; isolated from cephalaria transsylvanica
transsylvanoside H: a triterpenoid saponin; isolated from cephalaria transsylvanica
transthyretin receptor: a 115 kda transthyretin-binding oocyte membrane protein
transthyretin, Ala(60)-: associated with irish (donegal) amyloidosis
transthyretin, Arg(10)-: associated with familial amyloid polyneuropathy
transthyretin, Gly(42)-: type of amyloid prealbumin in which glu in position 42 is replaced by gly
transthyretin, Ile(50)-: attr ser50ile has substitution of isoleucine for serine at position 50; associated with familial amyloidotic polyneuropathy
transthyretin-methionine(111): has substitution of methionine for leucine at position 111; associated with hereditary amyloidosis and cardiomyopathy
transthyretin-related amyloid fibril protein, human: variant transthyretin (ttr) with a single amino acid substitution of methionine for valine at position 30; mw 15 kda; cerebrovascular amyloid fibril protein
transthyretin-related protein, mouse: an hiu hydrolase; genbank ak013117
transvalencin A: a thiazolidine zinc complex antibiotic produced by a clinical isolate of nocardia
transvalencin Z: antimicrobial compound with salicylic acid residue from nocardia transvalensis ifm 10065
trappin-2 A62L: derived from elafin and secretory leukocyte protease inhibitor; inhibits neutrophil serine protease
traptavidin: variant (synthetic construct of traptavidin gene) with slower biotin dissociation and increased mechanostability; genbank gu952124
trastuzumab deruxtecan: has both dna topoisomerase i inhibitory and antineoplastic activities; consists of dx-8951 conjugated to a humanized anti-her2 antibody
trastuzumab duocarmazine: her2-targeting antibody-drug conjugates of trastuzumab
trastuzumab-vc-MMAE: antibody-drug conjugate; mmae - monomethyl auristatin e
tratinterol: a beta2-adrenergic receptor agonist with bronchodilator activity
trbA protein, E coli: amino acid sequence given in first source; represses transcription of trfa and and trbb (kilbi) genes
trbB protein, Salmonella typhimurium: a trbb deletion mutation in the r64 plasmid results to a residual transfer activity; mw 43 kda; isoelectric point 6.2; amino acid sequence given in first source; genbank d63849
trbC protein, E coli: periplasmic protein required for pilus assembly, dna transfer proficiency, and plays an important role in mpf during conjugation; genbank x61575
trbE protein, E coli: amino acid sequence given in first source; a small, integral, membrane protein isolated from e coli
trbl protein, Drosophila: coordinates mitosis and morphogenesis in drosophila; amino acid ; refseq nm_079933
trc protein, Drosophila: required for epidermal cell extension integrity in drosophila; a member of the ndr kinase family; refseq nm_079446
trebananib: a selective angiopoietin 1/2-neutralizing peptibody
trefentanil: rn refers to hydrochloride; a short-acting analgesic
trefoil factor, xP2, Xenopus: from xenopus laevis skin; member of the tff- (or p-domain) peptide family of potential growth factors; amino acid sequence given in first source
tregalizumab: humanised, monoclonal, anti-cd4 igg antibody
trehalamine: aglycone of trehazolin; inhibits silkworm trehalase and exo-alpha glucosidases weakly
trehalose 2,3,6'-trimycolate: isolated from rhodococcus aurantiacus
trehalose dicarboxylic acid bis-(N,N-dioctadecylamide): a "mirror amide" pseudo-cord-factor glycolipid
trehalose mycolyltransferase: from mycobacterium smegmatis; catalyzes exchange of a mycolyl group between trehalose, trehalose 6-monomycolate & trehalose 6,6'-dimycolate
trehalose repressor protein, bacteria: repressor of the trehalose phosphotransferase system; has been sequenced
trehalose synthase: catalyzes the conversion of maltose into alpha,alpha-trehalose by intramolecular transglucosylation; in yeast the trehalose synthase complex consists of several proteins including tps2
trehalose-6-phosphate phosphorylase: catalyzes the reversible conversion of trehalose-6-phosphate and inorganic phosphate to glucose-1-phosphate and glucose-6-phosphate
trehalose-6-phosphate synthase: genbank x67499 (ggs1), u63416 (tpsb protein)
trehalose-6-phosphate synthase-phosphatase complex: involved in the synthesis of trehalose during mild heat-shock; subunits are encoded by tps1 & tps2; from saccharomyces cerevisiae; contains ec 2.4.1.15 & ec 3.1.3.12
trehalose-phosphatase: hydrolyzes trehalose 6-phosphate to trehalose + phosphate
trehalosyl dextrin-forming enzyme, Sulfolobus solfataricus: from the thermophilic archaeon sulfolobus solfataricus; catalyzes an intramolecular transglycosyl reaction to form trehalosyl dextrins from dextrins by converting the alpha-1,4-glucosidic linkage at the reducing end to an alpha-1,1-glucosidic linkage; mw about 87 kda; amino acid ; genbank aak42274
tremelimumab: a fully human anti-cytotoxic t lymphocyte-associated antigen 4 monoclonal antibody for immunotherapy of metastatic melanoma
tremellan: from a yeast-like fungus tremella mesenterica; has in vitro immunostimulatory activity
tremetol: active extract obtained from white snakeroot plant (eupatorium urticaefolium reichard); ingestion of milk from cows who have grazed on weed produces serious, sometimes fatal intoxication of syndrome called milk sickness, characterized by severe ketoacidosis; extract has at least 6 components, 3 of which are ketone derivs of benzofuran
tremortin: tremorigenic toxin from penicillium palitans & p.crustosum; rn given refers to cpd with unknown mf
trestatin: mixture of trestatin a,b,c with mw of 1435, 970 & 1901, respectively; principal chemical structure similar to that of acarbose; rn in chemline for trestatin a: 71884-70-3; trestatin b: 71869-92-6; trestatin c: 71892-68-7
tretazicar: minor descriptor (75-84); on-line & index medicus search aziridines (75-84)
trhd protein, Xenopus: inhibits neural differentiation through regulation of proliferation; th-b is an oligomeric variant; amino acid
tri(carbonyl)chloridophenylalaninatoruthenium(II): a carbon monoxide-releasing compound
tri-(2-ethylhexyl)trimellitate: authors commonly refer to it as trioctyl trimellitate
tri-n-butylmethylammonium: rn given refers to iodide
tri-nor-eudesm-5-en-7beta,8beta-diol: from inula racemosa
tri-snRNP-specific protein, 27-kDa, human: a trin-snrnp specific-protein; the 27kda protein contains an n-terminal sr domain strongly homologous (54% identity) to the sr domain of the u1 snrnp-specific 70k protein; amino acid given in first source
tri-torrat: combination of metipranolol, buthiazide & dihydralazine
tri-xylenyl phosphate: rn given refers to cpd with unspecified methyl-locants
triabin: isolated from the blood-sucking bug triatoma pallidipennis; genbank x80246
triacetic acid lactone lyase: non-hydrolytic; froms acetyl-coa from triacetic acid lactone plus atp plus coa
triacetoxyvinylsilane: has been used as a precursor to prepare sol-gel under aqueous conditions
triacsin A: isolated from streptomyces sp.; ; an acyl-coa synthetase inhibitor
triacsin B: isolated from streptomyces sp.; ; an acyl-coa synthetase inhibitor
triacsin C: from streptomyces no. 1228; ; an acyl-coa synthetase antagonist
triacsin D: inhibits long chain acyl-coa synthetase; from streptomyces no. 1228
triadin: binds the ryanodine & dihydropyridine receptors in skeletal muscle triadic vesicles; binds histidine-rich calcium-binding protein; not the same as junctional foot protein
triafestin-1, Triatoma infestans: plasma kallikrein-kinin system inhibitor from salivary glands of the blood-sucking insect triatoma infestans; genbank ab292809
triafestin-2, Triatoma infestans: plasma kallikrein-kinin system inhibitor from salivary glands of the blood-sucking insect triatoma infestans; genbank ab292810
triakontatetraneuropeptide: amino acid sequence given in first source; major biologically active processing product of diazepam binding inhibitor
triallyl-1,3,5-triazine-2,4,6-trione: used in photopolymerization of dental restoratives
trialysin protein, Triatoma infestans: a pore-forming cytolytic protein isolated from the insect vector of chagas' disease; genbank af427486
triaosylceramide 1,4-galactosyltransferase: involved in synthesis of neolacto-glycolipids
triaqua(1,3,5-tris(3',5'-dicarboxy(1,1'-biphenyl)-4-yl)benzene)tricopper(II): a microporous metal-organic framework that adsorps hydrogen gas
triaquaoxohexakis(propionato)trichromium(III): used as a nutritional supplement
triaquatricarbonyltechnetium(I): used to radiolabel microspheres
triazacyclononane macrocyclic porphyrin: functional model for cytochrome c oxidase
triazolium-bis(triazole)tetrachlororuthenate(III): model
triazoloquinazoline: class of compounds with antimicrobial and antioxidant activities
tribenoside: anti-inflammatory agent used in edema of extremities, varicose veins & phlebitis; minor descriptor (75-86); on-line & index medicus search glycosides (75-86); rn given refers to parent cpd without isomeric designation
tribenzyl phosphate: inhibits phosphate transport and atp synthesis in yeast mitochondria
tribestan: contains furostanolsaponins protodioscin, protogracillin, dioscin, & gracillin
tribulin: endogenous monoamine oxidase inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; isatin is a major component; produced in excess following alcohol withdrawal;
tributyl thiophosphate: rn in chemline for cpd specified as o,o,o-tributyl ester: 78-47-7; an herbicide
tributylhexadecylphosphonium bromide: a selective nuclear factor of activated t cells (nfat) signaling inhibitor
tributylstannic (3-(3,5-dimethylphenylamido)propionate): has antiviral activity
tributyltin: rn given refers to parent cpd; also includes halides; extensively used as antifouling biocides in paints on ships and fishnets;
tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate ca9(hpo4)(po4)5(oh) is the calcium orthophosphate leading to beta tricalcium phosphate ca3(po4)2 (b-tcp)
tricalcium phosphate lysine: drug delivery system based on tricalcium phosphate ceramics and lysine
tricalycoside: antibiotic from tricalysia coriacea (rubiaceae)
tricalysin H: anti-inflammatory from the twigs of tricalysia fruticosa
tricaprylin: 13c-labeled trioctanoin used in breath tests to detect fat malabsorption
tricarbonyl(1,10-phenanthroline-5,6-dione)rhenium(I): a platelet activating factor inhibitor
tricarbonyl(N(alpha)-fluorenylmethoxycarbonyl-N(epsilon),N(epsilon)-bis(pyridin-2-ylmethyl)lysine)rhenium(I): used to label peptides in preparation of radiopharmaceuticals
tricarbonyl(N-phenylcyclopentadienylcarboxamide)technetium(I): an acetylcholinesterase substrate for studying the enzyme's activity
tricarbonylchloro(glycinato)ruthenium(II): a cardioprotective agent
tricarbonyldichlororuthenium (II) dimer: an organometallic complex slowly metabolized to release carbon monoxide
tricatechol hexalactam-bismuth(III) complex: macrocyclic complex; no specific chemical name given in first source
tricatechol hexalactam-lead(II) complex: macrocyclic complex; no specific chemical name given in first source
tricepyridinium: from the culture of an e coli clone incorporating metagenomic libraries from the marine sponge discodermia calyx
triceteareth-4-phosphate: the triester of phosphoric acid and ceteareth-4, a surfactant and emulsifying agent used in body and hand cosmetic products
trichagmalin D: cytotoxic; from the leaves of trichilia connaroides
trichalasin C: isolated from one endophytic fungus trichoderma gamsii
trichalasin D: isolated from one endophytic fungus trichoderma gamsii
trichechol: bile acid from west indian manatee; ; rn given refers to the (5- beta) isomer
trichiconlide A: inhibits nitric oxide production; isolated from trichilia connaroides
trichloro(1-aza-4,7-dithiacyclononane)rhodium(III): has antineoplastic activity
trichloro(2,2'-6',2''-terpyridine)ruthenium: a chloropolypyridyl ruthenium complex
trichloro(8-(di(2-picolyl)amine-3-benzyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene)iron(III): has antineoplastic activity
trichloroacetic acid soluble protein, 14.5 kDa: a trichloroacetic acid-soluble inhibitor protein from human monocytes that is upregulated upon cellular differentiation; amino acid sequence given in first source; genbank x95384
trichlorobenzene: commercial grade of trichlorobenzene containing 70% 1,2,4-trichlorobenzene & 30% 1,2,3-trichlorobenzene; see also record for 1,2,4-trichlorobenzene
trichlorofluoromethane: refrigerant, aerosol propellant; rn given refers to parent cpd
trichloromethyl-phenyl-t-butyl nitrone: more stable nitroxyl spin adduct formed from the spin-trapping agent phenyl-t-butyl nitrone; rn given is from ca vol 90 chem form index
trichloromethylsulfenyl chloride: a highly toxic volatile inhalation poison
trichloronitritodiammineplatinum(IV): has antineoplastic activity
trichloronitrosylruthenium: a water soluble, thermally stable and no-donor compound
trichlorophene: contains 20 carbon atoms; do not confuse with trichlorophene as name for trichloro derivs of 2,2'-methylenebisphenol (contain 13 carbon atoms)
trichloropropylphosphate: rn given for cpd with unspecified chloro-locants
trichlorotriamminerhodium(III): rn given refers to (cis)-isomer
trichoacorenol B: neural anti-inflammatory cpd from the endophytic fungus trichoderma sp. xy24
trichoacorenol C: neural anti-inflammatory cpd from the endophytic fungus trichoderma sp. xy24
trichobitacin protein, Trichosanthes kirilowii: a ribosome-inactivating protein purified from the root tubers of trichosanthes kirilowii
trichocarpine A: from aconitum tanguticum var. trichocarpum
trichocarpine B: from aconitum tanguticum var. trichocarpum
trichocellin: composed of 20-residue peptaibols from trichoderma viride; the n-terminal amino acid is protected by an acetyl group, the c-terminal amino alcohol is phenylalaninol; amino acid sequence given in first source;tc-a-ii may be identical to saturnisporin ii
trichochrome C: pigment in urine in melanoma; see trichosiderin b; rn given refers to trichochrome c
trichocitrin: antibiotic from the marine brown alga-endophytic fungus trichoderma citrinoviride cf-27
trichoclin acetate: natural furocoumarin, from the aerial parts of phebalium aff
trichocyalide A: from the culture broth of trichoderma sp. fki-5513
trichocyalide B: from the culture broth of trichoderma sp. fki-5513
trichocyclodipeptide A: from the ascomycete fungus stagonospora trichophoricola
trichocyclodipeptide B: from the ascomycete fungus stagonospora trichophoricola
trichocyclodipeptide C: from the ascomycete fungus stagonospora trichophoricola
trichodenone-A: cytotoxic substance produced by a fungal strain from a sponge
trichodenone-B: cytotoxic substance produced by a fungal strain from a sponge
trichodenone-C: cytotoxic substance produced by a fungal strain from a sponge
trichoderamide A: from the plant endophytic fungus trichoderma gamsii
trichoderamide B: from the plant endophytic fungus trichoderma gamsii
trichoderic acid: antimicrobial from the endophytic fungus trichoderma sp. pr-35 of paeonia delavayi
trichoderide A: isolated from the marine fungus trichoderma reese, showed moderate cytotoxity against human a375-s2 melanoma cell line
trichoderin A: isolated from a culture of marine sponge-derived fungus of trichoderma sp.
trichoderin A1: isolated from a culture of marine sponge-derived fungus of trichoderma sp.
trichoderin B: isolated from a culture of marine sponge-derived fungus of trichoderma sp.
trichodermaerin: from the marine fungus trichoderma erinaceum associated with the sea star acanthaster planci
trichodermamide A: from cultures of the marine-derived fungus trichoderma virens
trichodermamide B: from cultures of the marine-derived fungus trichoderma virens
trichodermamide C: from the endophytic fungus eupenicillium sp.
trichodermatide A: cytotoxic polyketide from the marine-derived fungus trichoderma reesei
trichodermin esterase: mucor racemosus inducible enzyme which deacetylates trichodermin to trichodermol
trichoderpyrone: cytotoxic, from the plant endophytic fungus trichoderma gamsii
trichodiene: precursor of trichothecin; rn given refers to (s-(r*,r*))-isomer
trichodiene synthetase: formerly ec 4.1.99.6; catalyzes the isomerization-cyclization of farnesylpyrophosphate to form the bicyclic olefin trichodiene; consider also farnesylpyrophosphate cyclase
trichodone A: from the crude extract of the endophytic fungus trichoderma asperellum
trichodone B: from the crude extract of the endophytic fungus trichoderma asperellum
trichodone C: from the crude extract of the endophytic fungus trichoderma asperellum
trichoflectin: an azaphilone from ascomycete trichopezizella nidulus
trichogin protein, Tricholoma giganteum: has antifungal activity; isolated from an edible mushroom; n-terminal amino acid
trichoharzianol: an antifungal from trichoderma harzianum f031
trichohyalin: a structural protein of hair, tongue, nail, and epidermis
trichokirin protein, Trichosanthes kirilowii: mw 27 kda; extracted from the seeds of trichosanthes kirilowii maximowicz; risobsome-inactivating protein
tricholomalide A: neurotrophic diterpene from the mushroom tricholoma sp
tricholomalide B: neurotrophic diterpene from the mushroom tricholoma sp
tricholomalide C: neurotrophic diterpene from the mushroom tricholoma sp
tricholomic acid: depending on isomer, can act on nmda, ampa, ka, or mglu receptors
tricholongin BI: 19 amino acid residue peptaibol from trichoderma longibrachiatum; amino acid sequence given in first source
tricholongin BII: 19 amino acid residue peptaibol from trichoderm longibrachiatum; amino acid sequence given in first source
tricholysine: complex of fibrinolytic enzymes from trichothecium roseum; contains solizyme, amylase, and terrilytin
trichomaglin: an rna n-glycosidase and ribosome-inactivating protein isolated from the plant trichosanthes lipiniate
trichomide A: has immunosuppressive activity; isolated from trichothecium roseum
trichomycin A: antibacterial triterpene from tricholoma sp. au1
trichomycin B: antibacterial triterpene from tricholoma sp. au1
trichopeptide A: from the ascomycete fungus stagonospora trichophoricola
trichopeptide B: from the ascomycete fungus stagonospora trichophoricola
trichopolyn: polypeptide antibiotics isolated from trichoderma; active against fungi, gram-positive & acid-fast bacteria; rn given refers to trichopolyn a
trichopyrone: a free radical scavenger of 1,1-diphenyl-2-picrylhydrazyl radicals
trichoriboside: a mixture of polydeoxyribonucleic acids; used for scalp hair maintenance in patients affected by androgenic alopecia; patent no. 1222701 (italy)
trichormamide A: antiproliferative cpd from the freshwater cyanobacterium trichormus sp. uic 10339
trichormamide B: antiproliferative cpd from the freshwater cyanobacterium trichormus sp. uic 10339
trichorovin-XIIa: a fluorescein-labeled aib (alpha-aminoisobutyric acid)-containing peptide derived from a peptaibol
trichorzianine: inhibits beta-1,3-glucanase; antibiotic group of related peptides produced by trichoderma harzianum
trichorzianine A IIIc: lipophilic peptide from trichoderma harzianum; amino acid sequence given in first source
trichorzianine B: inhibits beta-1,3-glucanase; from trichoderma harzianum; nonadecapeptide of the peptaibol class
trichosaccharide: a mixture of mucopolysaccharides; used for scalp hair maintenance in patients affected by androgenic alopecia; patent no. 1212143 (italy)
trichosetin: an antibiotic isolated from trichoderma harzianum and catharanthus roseus
trichosiderin B: amino acid pigment having delta(2,2')-bi(2h-1,4-benzothiazine) chromophore; pigment occurring in mammalian red hair
trichosporin B-IIIa: from trichoderma polysporum; amino acid sequence given in first source
trichosporin B-IIIb: from trichoderma polysporum; amino acid sequence given in first source
trichosporin B-IIIc: from trichoderma polysporum; amino acid sequence given in first source
trichosporin B-IIId: from trichoderma polysporum; amino acid sequence given in first source
trichosporin B-Ia: from trichoderma polysporum; amino acid sequence given in first source
trichosporin B-V: from trichoderma polysporum; amino acid sequence given in first source
trichosporin B-VIa: an ion-channel forming peptide that stimulates catecholamine secretion; amino acid sequence given in first source
trichostatic acid: related to trichostatin a & c, but does not have biological activity of these compounds; rn given refers to (+-)-isomer; rn for cpd without isomeric designation not avail 11/90
trichostatin A: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so dna is less available for transcription; do not confuse with trichosanthin which is a protein; found in streptomyces
trichostatin RK: from streptomyces sp. rk98-a74.
trichothecene 3-O-acetyltransferase: catalyzes o-acetylation of the trichothecene ring specifically at the c-3 position in an acetyl-coa-dependent manner; 451 amino acids, mw about 50 kda; amino acid ; genbank ab000874, ab011417 & ab009607 ( g zeae), ab014491 (f sporotrichioides)
trichothecene NX-2: from fusarium graminearum from barley and wheat
trichothecolone: rn given refers to (4beta)-isomer; rn for cpd without isomeric designation not in chemline 4/86
trichotine: douche used for vaginitis containing sodium lauryl sulfate, sodium perborate & sodium borate
trichotoxin A 50E: a peptaibiotic; alpha-aminoisobutyric acid-rich secondary metabolite of fungi; amino acid sequence given in first source
trichovirin I IB: a peptaibiotic, alpha-aminobutyric acid-rich secondary metabolite of fungi; amino acid sequence given in first source
trichrome stain: composed of light green, bismark brown, eosin, lithium carbonate, & phosphotungstic acid
tricin 4'-O-guaiacylglyceryl ether: isolated from arenaria kansuensis
tricin 7-O-glucopyranoside: isolated from arenaria kansuensis
tricin-7-O-beta-(6''-methoxycinnamic)glucoside: a tricin acylated glycoside from sugarcane (saccharum officinarum) juice with antiproliferative and antioxidant activities
tricladic acid A: from the aquatic hyphomycete tricladium castaneicola
tricladic acid B: from the aquatic hyphomycete tricladium castaneicola
tricladic acid C: from the aquatic hyphomycete tricladium castaneicola
triclocarban: bacteriostat; antiseptic in soaps & other cleansing solns; germicide
triclofos: derivative 7 metabolic precursor of trichloroethanol; rn given refers to parent cpd
tricorn protease: a tricorn-shaped protease from the archaeon thermoplasma; acts as a core of the proleolytic system; six identical units of 120 kda form a large tricorn complex (tri); amino acid sequence given in first source; genbank u72850
tricorn protease interacting factor 2: closely related aminopeptidases of 89 kda, in conjunction with this factor, tricorn degrades oligopeptides in a sequential manner, yielding free amino acids; amino acid
tricornoside A: benzophenone o-glycoside from the roots of polygala tricornis
tricothecium polysaccharide: complex polysaccharide from fungus trichothecium roseum which induces resistance against a number of viruses in host plants
tricresyl ethyl phthalate: constituent of plastic nails; may cause contact dermatitis
tricuspidatin: from fruits of trichosanthes tricuspidata (cucurbitaceae) collected in north vietnam, cytotoxic to kb cells
tricyclic cyclosporin A: tricyclic variant of cyclosporin a; inhibits the proliferation of t lymphocytes by forming a cyclophilin-cyclosporin-calcineurin complex
tricyclic pyrones: synthetic pyrone derivatives characterized by three unsaturated, six-membered rings
tricyclic-dimeric-peptide-6: peptide mimetic structurally based on the loop-2 region of the bdnf homodimer that interacts with trkb
tricyclo(6.3.1.0(1,6))dodec-5-ene-4,9-dione 9,9-ethylene acetal: key precursor for aphidicolane- and stemodane-type diterpenes
tricycloalterfurene B: from the marine-alga-epiphytic fungus alternaria alternata k21-1
tricycloclavulone: prostanoid-related marine oxylipin, isolated from the okinawan soft coral clavularia viridis
tricycloillicinone: a tricyclic prenylated c6-c3 compound; isolated from the woods of illicium tashiroi
tridacnin: precipitin from hemolymph of elongate clam, tridacna maxima; reacts with beta-o-d-galactopyranosyl-(1-6)-d- galactose structures present in most galactans; invertebrate lectin; has precipitating, agglutinating & mitogenic activity
tridbisbithiophene: bis-bithiophene from tridax procumbens l. (asteraceae)
tridecaptins: tridecaptins a,b & c isolated from bacillus polymyxa; all acyl tridecapeptides differing in fatty acid & amino acid residues
tridegin: a 66 amino acid residues, 7.6 kda potent peptidic inhibitor from salivary gland extract of the giant amazon leech, haementeria ghilianii
tridentate triaquarhodium-adenosine 5'-triphosphate complex: ; rn refers to the (oc-6-44-a-(r-(r*,r*)))-isomer
tridictyophylline: morphinan alkaloid from triclisia dictyophylla (menispermaceae)
tridihexethyl: synonym pathilon refers to chloride; rn given refers to parent cpd
tridihomo-gamma-linolenoylglycerol: reduces leukotriene b4 production
tridin: fluoride-calcium combination for osteoporosis treatment; contains calcium gluconate, calcium citrate, sodium monofluorophosphate & carboxymethylcellulose