NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
pilosulin 3: displayed antimicrobial activity with histamine-releasing and low hemolytic activities
pilosulin 4: displayed antimicrobial activity with histamine-releasing and low hemolytic activities
pilosulin 5, Myrmecia pilosula: a histamine-releasing peptide from the venom of the australian ant, myrmecia pilosula (jack jumper ant); a dimmer peptide of 8546da; has been sequenced
pim1 protein, S pombe: s pombe protein is gdp/gtp exchange factor (rangef) (predicted), involved in mitotic checkpoint, involved in metaphase-anaphase transition
pimC protein, Mycobacterium tuberculosis: a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis; amino acid
pimafucort: combination of pimaricin 10 mg, neomycin sulfate 5 mg & hydrocortisone 10 mg
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications
pimara-7,15-diene: ; rn given refers to (4as-(4aalpha,4balpha,7alpha,10aalpha))-isomer
pimaricin-inducing factor, Streptomyces natalensis: isolated from wild type s. natalensis
pimavanserin: a 5-ht(2a) inverse agonist; acp-103 is the dihydroxybutanedioate (2:1) salt. it is used to treat hallucinations and delusions associated with parkinson disease
pimelautide: ; rn given refers to (threo)-l-lysine isomer
pimelic diphenylamide 106: a histone deacetylase inhibitor
pimelyl-coenzyme A: required for anaerobic benzoate degradation by rhodopseudomonas palustris
pimexone: respiratory analeptic; rn given refers to parent cpd;  & in negwer, 5th ed, #6503
pimodivir: non-nucleotide inhibitor of the polymerase basic protein 2 (pb2) subunit of the influenza a that is active against h1n1, h7n9 and h5n1, as well as influenza a strains with reduced susceptibility to nais
pimplin protein, Pimpla hypochondriaca: genbank aj427449.1
pinane-thromboxane A2: rn given refers to (1s-(1a alpha,2 beta(z),3 alpha(1e,3s*),5 alpha))-isomer
pinatuzumab vedotin: an antineoplastic agent that consists of a monoclonal antibody igg1 joined to monomethyl auristatin e
pinealon: synthetic tripeptide that increases cell viability by suppression of free radical levels and activating proliferative processes
pinen-10-yl vicianoside: rn given for (1s-(1alpha,2z,5alpha))-isomer; monoterpene glycoside from paeonia lactiflora roots
pinene cyclase I: converts geranylpyrophosphate to (+)-alpha-pinene & small amounts of (+)-camphene & (+)-limonene; isolated from mentha
pinene cyclase II: forms (-)-alpha-pinene & (-)-beta-pinene, plus small amounts of (-)-camphene, (-)-limonene & myrcene
pinene cyclase III: from sage, salvia officinalis; catalyzes the conversion of geranylpyrophosphate to (+)-alpha-pinene & (+)-beta pinene plus small amounts of monocyclic & acyclic monoterpene olefins
ping-tang: used to treat hepatic steatosis and insulin resistance; consists of rhizoma alismatis, rhizoma atractylodis macrocephalae, rheum palmatum l. and crataegus pinnatifida
pingpeimine glucoside: neither c- nor d-homosteroid alkaloid glucoside; isolated from fritillaria ussuriensis maxim
pinguinain: protease glycoprotein isolated from bromelia pinguin fruit with properties similar to papain
pinholin S(21) protein, phage phi21: a prototype holin of bacteriophage phi21
pinicolol B: has antineoplastic activity; isolated from antrodia cinnamomea
pinidinone: alkaloid from many picea (spruce) and/or pinus (pinus) species
pink-eye dilution protein, rat: 842 amino acid residues; genbank ab191343
pinnatifidenyne: medium ring haloetheres isolated from the red algae laurencia pinnatifida
pinnatifin I: isoalted from the leaves of crataegus pinnatifida
pinnatoside A: has free radical scavenging activity; isolated from paullinia pinnata
pinnigorgiol A: a 9-11 secosterol isolated from gorgonian coral pinnigorgia sp.; induces apoptosis of hsc-t6 cells
pinobanksin: a flavonoid from propolis; rn refers to (2r-trans)-isomer
pinocamphone: rn given refers to (1 alpha,2 alpha, 5 alpha)-isomer
pinocarvone: antioxidant and cytotoxic compound from the essential oil from cedronella canariensis var. canariensis
pinocembrin 7-O-apiosyl(1-5)apiosyl(1-2)glucopyranoside: phenolic glycoside from viscum angulatum
pinocembrin-7-O-(3''-O-galloyl-4'',6''-hexahydroxydiphenoyl)-beta-glucose: from penthorum chinense p.
pinophilin A: from cultures of a fungus (penicillium pinophilum hedgcok) derived from a seaweed
pinophilin B: from cultures of a fungus (penicillium pinophilum hedgcok) derived from a seaweed
pinopsin protein, chicken: a pineal/brain photoreceptive molecule; genbank u15762
pinoresinol: in plants; a furo[3,4-c]furan created from dimer of coniferyl alcohol
pinoresinol 4-O-glucopyranoside: isolated from solanum nigrum
pinoresinol diglucoside: major antihypertensive principle of tu-chung (eucummia ulmoides, oliver)
pinoresinol reductase: catalyzes the conversion of pinoresinol to lariciresinol; isolated from forsythia intermedia
pinoresinol-4,4'-di-O-beta-D-glucopyranoside: from the fruit of acanthopanax sessiliflorus
pinosylvin-O-methyltransferase: involved in stilbene synthesis in scots pine; amino acid
pinusolide: rn given for (1s-(1alpha,4aalpha,5a,8abeta))-isomer
pinx1 protein, zebrafish: has similarities to human lpts/pinx1 that inhibits telomerase activity; genbank ay576808
pio protein, Drosophila: essential for the generation of the interconnected tracheal network in drosophila melanogaster; amino acid ; refseq nm_166677
pip protein, Drosophila: st1 and st2 are isoforms with homology to heparan-sulfate 2-sulfotransferase; defines dorsal-ventral polarity in drosophila embryo; genbank af102135 and af102136; refseq nm_079434
pip92 protein, rat: proline-rich protein of 221 amino acids; plays a role in mediating cellular responses; amino acid sequence given in first source
pipecolate-activating enzyme: from streptomyces hygroscopicus var. ascomyceticus, which produces immunomycin; reaction appears to use an aminoacyl adenylate as an intermediate in the activating reaction
pipecolate-incorporating enzyme, Streptomyces: involved in the biosynthesis of rapamycin in streptomyces hygroscopicus; a monomer under native conditions; amino acid sequence known
pipecolidepsin A: isolated from the marine sponge homophymia lamellosa
pipecolidepsin B: cytotoxic; from the madagascan sponge homophymia lamellosa
pipecolyl-leucyl-glycinamide: substituted tripeptide analog of the c-terminal part of oxytocin
piperacetazine: was mh 1975-91 (see under phenothiazine tranquilizers 1975-90)
piperarborenine B: cytotoxic; isolated from the stems of the creeping shrub piper arborescens
piperarborenine D: cytotoxic; isolated from the stems of the creeping shrub piper arborescens
piperastatin A: a serine carboxypeptidase inhibitor; produced by actinomycete
piperastatin B: a serine carboxypeptidase inhibitor from streptomyces lavendofoliae; pip - piperazic acid, hexahydropyridadine-3-carboxylic acid
piperazic acid: inhibitor of gaba; cpd not in chemline 8/18/83
piperazimycin A: from a marine-derived bacterium of the genus streptomyces
piperazimycin B: from a marine-derived bacterium of the genus streptomyces
piperazimycin C: from a marine-derived bacterium of the genus streptomyces
piperazine-N,N'-bis(2-ethanesulfonic acid): rn given refers to parent cpd
piperazinyl-cross-linked ciprofloxacin dimer: antibacterial, effective on staphylococcus aureus
piperbonin A: isolated from the aerial parts of piper bonii (piperaceae)
piperbonin B: isolated from the aerial parts of piper bonii (piperaceae)
piperidino-1-(methylcyclohexane): rn given refers to parent cpd
piperidonium: derivative of piperidine; no other info available 6/9/80
piperkadsin C: anti-inflammatory agent that inhibits no production in microglia cells; isolated from piper kadsura
piperogalin: a prenylated diphenol; from peperomia galioides
piperonyl-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine-3-carboxamide: an anxiolytic agent
piperoside: an antioxidant with alpha-glucosidase inhibitory activity; isolated from piper retrofractum
piperulin A: a neolignan; from piper puberulum; a platelet activating factor receptor antagonist
piperulin B: a neolignan; from piper puberulum; a platelet activating factor receptor antagonist
piperulin C: a neolignan; from piper puberulum; a platelet activating factor receptor antagonist
pipinin-1 peptide, Rana pipiens: insulin-releasing agent; 20-amino acid peptide from skin secretions of rana pipiens frogs
pipothiazine: was heading 1975-94 (see under phenothiazine tranquilizers 1975-90); use phenothiazines to search pipothiazine 1975-94; a member of the family of phenothiazine tranquilizers
pipothiazine palmitate: was heading 1975-94 (see under phenothiazine tranquilizers 1975-90); use pipothiazine to search pipothiazine palmitate 1975-94; palmitate ester of pipothiazine; member of phenothiazine family of tranquilizing agents
pipothiazine undecylenate: rn given refers to 10-undecenoic cpd; structure in negwer, 5th ed, #5954
pipoxolan: synonyms br-18 & rowapraxin refer to hcl
pipradrol: was heading 1963-94; pipradol was see pipradrol 1978-94; use piperidines to search pipradrol 1966-94
piprozoline: 10 articles in arzneim forsch 27(2b):467;1977
piquerol A: monoterpene from piqueria trinervia cav.; has inhibitory effect on the growth of epimastigotes of trypanosoma cruzi; rn given refers to cis-(3,6-(+)-isomer; rr refers to piquerol b
piracetam, vinpocetine drug combination: contains 5 mg vinpocetine and 400 mg piracetam; has vasodilator and nootropic actions; used for treatment of chronic brain ishemia
piratoxin I: a myotoxic lys49-phospholipase a homolog from venom of bothrops pirajai
piratoxin II: phospholipase a2 isolated from bothrops pirajai
piratoxin III: a phospholipase a2 isolated from the venom of bothrops pirajai
pirbenicillin: rn given refers to (2s-(2 alpha,5 alpha,6 beta))-isomer
piridoxylate: conjugation product of glyoxylic acid & pyridoxine; may be physiological regulator of cell respiration
pirin3 protein, Arabidopsis: a cupin domain protein; genbank np_030851
pirlindole: rn given refers to parent cpd; synonym pyrazidol refers to mono-hcl; structure in negwer, 5th ed, #2812
piroctone olamine: 2(1h)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis
pironetin: a microbial secondary metabolite having the activity of shortening plant height from streptomyces sp.
piroplasm surface protein p32, Theileria sergenti: isolated from theileria sergenti; amino acid sequence given in first source; genbank d12689 (clones c-2 and c-13), d12691 (clone l9-1)
piroxicam-beta-cyclodextrin: drug combination consisting of beta-cyclodextrin & piroxicam; rn given refers to unknown ratio
pirprofen: anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin
pirsidomine: a sydnonimine with direct vasodilating and nitric oxide-donating properties
pirtianol: selectively stimulates immature prothymocytes to differentiate into mature thymocytes
pirtobrutinib: an orally available, selective, non-covalent bruton's tyrosine kinase inhibitor with potential antineoplastic activity
pisatin: phytoalexin produced in plants after injection with fungi; rn given refers to (6as-cis)-isomer
pisavin protein, Pisum sativum: 20.5 & 18.7 kda ribosome-inactivating proteins from garden pea, pisum sativum; have been sequenced
piscicolin 126: a bacteriocin produced by carnobacterium piscicola
piscidic acid: active constituent for chronic bronchitis isolated from root of chuan-shan-long plant; rn given refers to cpd without isomeric designation
piscidin 4, striped bass: 44-mer peptide isolated from the hybrid striped bass (morone chrysops female x m. saxatilis male); amino acid
piscivostatin: a dimeric disintegrin containing arg-gly-asp (rgd) and lys-gly-asp (kgd) sequences, was isolated from the venom of agkistrodon piscivorus piscivorus; amino acid
piscroside C: isolated from pseudolysimachion rotundum var. subinegrum suppresses airway inflammation induced by cigarette smoke
pisiferic acid: from chamaecyparis pisifera; rn given refers to 4ar-trans parent cpd
pisosterol: a cytotoxic terpene from pisolithus tinctorius that induces monocytic differentiation in hl-60 cells
pistacide A: isolated from the methanolic extract of the aerial parts of pistacia integerrima
pistacide B: isolated from the methanolic extract of the aerial parts of pistacia integerrima
pistafolia A: gallotannin from the leaf extract of pistacia weinmannifolia (anacardiaceae)
pistillarin: immunosuppressive compound from the mushroom rubinoboletus ballouii
pisumin protein, Pisum sativum: an antifungal protein from legumes of the sugar snap pea pisum sativum var macrocarpon; mw 31kda, n-terminal
pisumoside A: from green peas, the immature seeds of pisum sativum l.
pisumoside B: from green peas, the immature seeds of pisum sativum l.
pisumsaponin I: from green peas, the immature seeds of pisum sativum l.
pisumsaponin II: from green peas, the immature seeds of pisum sativum l.
pita protein, Drosophila: spotted-dick/pita functions as a transcription factor in the coordination of cellular growth and dna replication; has been sequenced; refseq nm_137962
pitamin: a standard korean red pine bark extract; also contains grape seed, green tea and gingko; a possible antibiotic replacement for chickens
pithelucoside A: cytotoxic triterpenoid saponin from pithecellobium lucidum
pithelucoside B: cytotoxic triterpenoid saponin from pithecellobium lucidum
pithelucoside C: cytotoxic triterpenoid saponin from pithecellobium lucidum
pitipeptolide A: from the marine cyanobacterium lyngbya majuscula
pitipeptolide B: from the marine cyanobacterium lyngbya majuscula
pitiprolamide: a proline-rich dolastatin 16 analog from the marine cyanobacterium lyngbya majuscula from guam
pitolisant: functions as both inverse agonist and antagonist of histamine h3 receptors
pitrakinra: an interleukin-4 variant and anti-asthmatic agent
pitrazepin: effects are not tissue specific; induced a bursting discharge pattern in cultures derived from hippocampus & hypothalamus
pitrilysin: mg-dependent; acts on a limited no. of small polypeptides of mw less than 6,000 such as insulin, glucagon & autoclaved beta-galactosidase fragments; formerly ec 3.4.99.44
pittoviridoside: triterpene saponin from pittosporum viridiflorum (pittosporaceae) from the madagascar rainforest
pituitary adenylate cyclase-activating-peptide (1-38), pig: a neurotransmitter from pig pancreas
pituitary adenylate-cyclase-activating peptide (6-27): blocks adrenal catecholamine response to vasocative intestinal peptide (vip)
pituitary adenylate-cyclase-activating-peptide (6-38): a potent antagonist of pacap
pituitary polypeptide P16: carboxy-terminal cleavage product of rat growth hormone in anterior pituitary and gh3 pituitary tumor cells
pituitary tumor-transforming protein 1, human: pttg - pituitary tumor transforming gene; refseq nm_004219
pityrialactone: a fluorochrome from the tryptophan metabolism of malassezia furfur
pityriarubin A: a highly selective inhibitor of respiratory burst from cultures of the yeast malassezia furfur
pityriarubin B: a highly selective inhibitor of respiratory burst from cultures of the yeast malassezia furfur
pityriarubin C: a highly selective inhibitor of respiratory burst from cultures of the yeast malassezia furfur
pityriazepin: an aryl hydrocarbon receptor activator; isolated from malassezia furfur yeast
pityriazole: a tryptophan metabolite isolated from malassezia furfur
pivaloyl-S-(N'-acetylalanyl)-cysteine ethyl ester: an analog of spm 5185 that lacks the no moiety
pivaloyloxymethyl 7-(2-(2-amino-4-thiazole)-2-methoxyiminoacetamido)-3-(2-propenyl)-3-cephem-4-carboxylate: prodrug to 3-(2-propenyl)cephalosporins
pivampicillin probenate: salt of pivampicillin & probenecid in 1:1 molar ratio
piwil1 protein, zebrafish: homologous to piwi from drosophila; expressed in gonads of adult zebrafish; amino acid ; refseq nm_183338
pkaA protein, Aspergillus nidulans: a camp-dependent kinase catalytic subunit
pkg3 protein, Streptomyces granaticolor: protein serine/threonine kinase from streptomyces granaticolor; separated by only 2 bases from pkg4; genbank aj223176
pkg4 protein, Streptomyces granaticolor: protein serine/threonine kinase from streptomyces granaticolor; separated by only 2 base pairs from pkg3; genbank aj223176
pkip protein, Autographa californica nucleopolyhedrovirus: acmnpv - autographa californica nuclear polyhedrosis virus; contains a putative nuclear localization signal; associates & stimutates protein kinase 1 in acmnpv virus-infected cells; amino acid
pknox1.2 protein, zebrafish: refseq xm_702776
plY protein, Streptococcus pneumoniae: from strep pneumoniae; sulfhydryl-activated toxin; is able to lyse cholesterol containing membranes; may be reversibly inactivated by oxidation; genbank m17717
plaA protein, Prevotella loescheii: a lectin-like adhesin from prevotella loescheii; partial amino acid sequence given in first source
placental antigen X-P2: associated with the cytochrome p-450 of aromatase
placental immunomodulatory ferritin protein, mouse: plays a major role in placentation and embryonic growth
placental lactogen A-2: a testicular alternative splicing variant hpl-a2, an unusual member of the human growth hormone/placental lactogen (gh/pl) family; a membrane-associated growth factor molecule; amino acid
placental lactogen I, rat: binds to the choroid plexus & hypothalamus of the pregnant rat; amino acid sequence has been determined
placental lactogen I-variant: member of prolactin family; amino acid sequence has been determined; has 88% sequence identity with pl-i, but differs in many other respects from pl-i
placental lactogen II: amino acid sequence given in first source; exact amino acid composition is species dependent
placental lactogen-3, human: gene expression is regulated by the transcription factor pla-1/skn-1a expressed in placenta
placental protein 11: found in human placenta and various malignant neoplasms; probably a serine protease; ec 3.4.21.-
placental protein 19: glycoprotein from human placenta; has alpha1-beta1 electrophoretic mobility; mw 36.5 kda
placental protein 21: found in human placenta and body fluids of patients with neoplasms
placental protein 3: flavin-containing protein which appears to be an enzyme; prosthetic group is fad; consists of 2 identical subunits mw 55kda; with an electrophoretic mobility between the alpha 1 and alpha 2 globulins
placental ribonuclease inhibitor: rnasin, is a purified human placental ribonuclease inhibitor, known to have antiangiogenic activity through the inhibition of angiogenin and basic fibroblast growth factor
plachitin: combination of cisplatin & chitin; used for intraarterial chemoembolization therapy
plaferon: a natural protein-peptide preparation; an antihypoxic agent; - "formerly known as plaferon"; no furthur information available 3/95; 5/97
plagiochilin A: converted to the hot-tasting compounds plagiochilal b and furanoplagiochilal by saliva; ; rn refers to (4r-(4alpha,4aalpha,5beta,7abeta,8abeta,8balpha))-isomer
plakalbumin: obtained by proteolytic modifaction of ovalbumin which releases heptapeptide glu-ala-gly-val-asp-ala-ala (residues 346-352)
plakevulin A: isolated from the okinawan sponge plakortis; has antineoplastic activity
plakilactone C: a ppargamma ligand; isolated from plakinastrella mamillaris
plakinamine E: steroidal alkaloid from sponge of the genus corticium (order homosclerophorida, family plakinidae)
plakinamine F: steroidal alkaloid from sponge of the genus corticium (order homosclerophorida, family plakinidae)
plakinamine M: a steroidal alkaloid from the marine sponge corticium sp
plakolide A: gamma-lactone from the marine sponge plakortis sp. that inhibits inducible nitric oxide synthase (inos) activity
plakorstatin 1: cancer cell growth inhibiting cyclic peroxide from the indonesian marine sponge plakortis nigra
plakorstatin 2: cancer cell growth inhibiting cyclic peroxide from the indonesian marine sponge plakortis nigra
plakortide E: trypanocidal protease inhibitor from the caribbean sponge plakortis halichondroides
plakortide M: from the caribbean marine sponge plakortis halichondrioides
plakortide N: from the caribbean marine sponge plakortis halichondrioides
plakortolide E: a cyclic peroxide; from plakortis sponge
plakortolide H: cyclic peroxide from the marine sponge plakortis aff simplex
plakortolide I: cyclic peroxide from the marine sponge plakortis aff simplex
plakortolide J: bioactive cycloperoxide from the puerto rican sponge, plakortis halichondrioides
plakortone L: isolated from the australian sponge, plakinastrella clathrata
plancitoxin I, Acanthaster planci: isolated from the crown-of-thorns starfish; genbank bad13432
planifolin: a naphthopyranone from paepalanthus planifolius
planktocyclin: a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium planktothrix rubescens
plant ferredoxin-like protein, Capsicum annuum: a ferrifdoxin from sweet pepper (capsicum annuum l.) with intensifying harpin(pss)-mediated hypersensitive response, shows an enhanced production of active oxygen species (aos); amino acid
plant mixture extract P-9801091: a hypoglycemic preparation containing myrtilli folium (vaccinium myrtillus l.), taraxaci radix (taraxacum of fi cinale web.), cichorii radix (cichorium intybus l.), juniperi fructus (juniperus communis l.), centaurii herba (centaurium umbellatum gilib.), phaseoli pericarpium (phaseolus vulgaris l.), millefoliiherba (achillea millefolium l.), mori folium (morus nigra l.), valerianae radix (valeriana of ficinalis l.) and urticae herba et radix (urtica dioica l)
plant product, moniliformin: from dendrobium moniliforme (orchidaceae); ; do not confuse with moniliformin, a mycotoxin
plant stanol ester: antilipamic agent lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children
plantacyanin, Arabidopsis: involved in pollination; genbank nm_126340
plantagiolide I: from tacca plantaginea; has nuclear factor-kappab inhibitory and peroxisome proliferator-activated receptor transactivational activities
plantagiolide J: from tacca plantaginea; has nuclear factor-kappab inhibitory and peroxisome proliferator-activated receptor transactivational activities
plantagoguanidinic acid: has hypoglycemic activity; isolated from plantago asiatica
plantagolisin: a subtilisin-like collagenase hydrolyzing chromogenic peptide substrate glp-ala-ala-leu-p-nitroanilide optimally at ph 8.1 was found in common plantain leaves; mw 19 kda; amino acid sequence known
plantagoside: ; isolated from the seeds of plantago asiatica; alpha-mannosidase inhibitor
plantainoside D: antioxidant from the leaves of picrorhiza scrophulariiflora (scrophulariaceae)
plantaricin 1.25: from lactobacillus plantarum; alpha & beta are two fractions, mw 5979 & 5203 da respectivelty; amino acid
plantaricin 149: isolated from lactobacillus plantarum; has been sequenced
plantaricin 423: class iia bacteriocin from lactobacillus plantarum 423 in saccharomyces cerevisiae; genbank af304384
plantaricin A: from lactobacillus plantarum; its activity depends on the action of two peptides
plantaricin ASM1, Lactobacillus plantarum: genbank ab474371
plantaricin C: produced by lactobacillus plantarum; mw 3.5 kda; n-terminal amino acid sequence given in first source
plantaricin EF: two-peptide bacteriocin isolated from lactobacillus plantarum; amino acid
plantaricin JK: two-peptide bacteriocin isolated from lactobacillus plantarum; amino acid
plantaricin L-1: an antilisteria bacteriocin produced by lactobacillus plantarum
plantaricin LD1: purified from lactobacillus plantarum ld1
plantaricin MG: mw 2,180-da, produced by lactobacillus plantarum klds1.0391, active against salmonella typhimurium
plantaricin SIK-83: from lactobacillus plantarum; inhibits 66 of 68 lactic acid bacteria from the genera lactobacillus, leuconostoc, pediococcus & streptococcus
plantaricin ST31: a bacteriocin produced by lactobacillus bavaricus; inhibits a wide range of lactic acid bacteria
plantaricin TF711: bacteriocin-like substance produced by lactobacillus plantarum; mw 2.5 kda
plantasioside: a phenylethanoid glycoside; from plantago asiatica
plantazolicin A: from bacillus amyloliquefaciens fzb42
plantazolicin B: from bacillus amyloliquefaciens fzb42
plasma clotting protein, Pacifastacus leniusculus: homologous to vitellogenins; genbank af102268
plasma protein Z: gamma-carboxyglutamic acid containing protein with n-terminal sequence different from but homologous with those of other vitamin k-dependent plasma proteins; do not confuse with z protein which is a cytoplasmic protein
plasmalogen-selective phospholipase A2: catalyzes hydrolysis of arachidonic acid from sn-2 position of plasmalogen
plasmalogenase: do not confuse with lysoplasmalogenase, which acts on compounds without the 2-acyl group
plasmanylethanolamine desaturase: converts 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine to alk-1-enyl-2-acyl-gpe (plasmenylethanolamine); requires cytochrome b5, molecular oxygen and either nadph or nadh
plasmanylinositol glycan: an insulin-sensitive glycan; a major part of the phosphatidylinositol glycan structure
plasmapepsin IV: enzyme from plasmodium falciparum degrades human hemoglobin starting in the alpha globin chain at the phe33-leu34 bond
plasmatocyte-spreading peptide 1: a 23 amino acid residues peptide from the hemolymph of pseudoplusia includens; amino acid sequence given in first source
plasmepsin: has 35% identity to human renin & represent new targets for antimalarial chemotherapy; amino acid sequence has been determined; see also plasmepsin ii
plasmid Ddp2 protein, Dictyostelium: amino acid sequence given in first source
plasmin C, Physarum polycephalum: amino acid sequence given in first source; from physarum polycephalum; small hydrophobic cysteine-rich protein
plasmin Paris-Trousseau: a g to a transition at the splicing donor site in intron 2 leads to three different types of plasmin inhibitor transcripts
plasmin heavy chain-urokinase conjugate: low mw urokinase coupled to heavy chain of plasmin; binds to fibrin
plasmin-alpha(2)-macroglobulin complex: alpha(2)m is plasma protease inhibitor; mw 725,000; for alpha-2-antiplasmin use alpha-2 antiplasmin (see antiplasmin); see also plasmin-alpha(2)-antiplasmin complex
plasmin-plasmin inhibitor complex: used in enzyme-linked differential antibody immunosorbent assay in blood for the determination of protein-cleaving enzymes; do not use /blood
plasminase A: isolated from embryonal carcinoma f9 cells; mw 160,000; serine protease which digests the light chain of plasmin in a time dependent inactivation process; heavy chain of plasmin not affected
plasminase B: isolated from embryonal carcinoma f9 cells; mw 82,000; serine protease which digests the light chain of plasmin in a time dependent inactivation process; heavy chain of plasmin not affected
plasminogen (S741C-fluorescein): a variant of recombinant plasminogen with the plasmin active site ser replaced by cys & labeled with fluorescein at this residue
plasminogen Chicago III: abnormal variant; from patient with recurring deep vein thrombosis; has both k(m) of activation defect with impaired activator binding & k(cat) of activation defect & impaired arg(560)-val peptide bond cleavage
plasminogen Maywood I: a dysplasminogenemia with active center and kinetic defects, type 1c
plasminogen activator, Agkistrodon blomhoffii Ussurensis: plasminogen activator with arginine ester hydrolysis activity from chinese agkistrodon blomhoffii ussurensis venom; a monomeric protein with molecular mass of 27815.2 da; partial amino acid
plasminogen kringle 5: a proteolytic fragment of plasminogen with potent angiogenic activity
plasminogen-binding protein, bacteria: from streptococcus & haemophilus; amino acid sequence given in first source; genbank z22219; do not confuse with the hydroxylase pam protein
plasminogen-related protein A, human: encodes 9-kda polypeptides; amino acid ; genbank u67178
plasminogen-valine: has nh2-terminal sequence of val-gln-asp
plasminostreptin: protein proteinase inhibitor produced by streptomyces antifibrinolyticus
plasmion: fluid gelatin modified with an ionic ringer lactate solution; may be the same as polygeline
plastatin: phospholipase a2 antagonist isolated from penicillium chermesinum
plastein: substance formed when peptic digests of certain proteins are concentrated and treated with pepsin under slightly acid conditions
plasticin: amino acid sequence given in first source; a novel type iii neurofilament protein from goldfish retina with increased expression during optic nerve regeneration
plasticin-L1 peptide, Leptodactylus laticeps: isolated from the santa fe frog
plastidic glycerol-3-phosphate acyltransferase, Arabidopsis: genbank d00672
plastochromanol 8: has antiproliferative activity against 3t3-l1 cells and anti-adipogenic activity; structure; plastochromanol 3 is gamma-tocotrienol
plastrum testudinis: a chinese preparation of reeves' turtle shell for the treatment of bone diseases
platanic acid: inhibits hiv replication; isolated from syzigium claviflorum
platelet adhesion inhibitor: isolated from human serum; has uv-absorption spectrum characteristic of proteins; antigenic to rabbits; no other information 7/3/80
platelet agglutinating protein, thrombotic thrombocytopenic purpura: mw 37,000
platelet aggregation-associated protein, Streptococcus: a collagen-like immunodeterminant on the surface of streptococcus sanguis that induces platelet aggregation
platelet endothelial cell activated protease: degrades casein and fibrinogen; secreted by endothelial cells and activated in the extracellular medium by platelets; not inhibited by serine protease inhibitors, metalloproteinase inhibitors, or cystein protease inhibitors; ph optimum 7.5
platelet factor 4 (59-70): elicits human neutrophil & monocyte chemotaxis
platelet factor V: protein in alpha granules of human platelets; accelerator of prothrombin conversion similar to plasma factor v
platelet inhibitory factor: mw 43kda; plasma factor that inhibits platelet thromboxane a2 release & renal prostaglandin e2 production
platelet membrane glycoprotein VI: a putative collagen receptor; n-terminal 15 amino acid sequence given in first source
platelet microbicidal protein, Oryctolagus cuniculus: platelet alpha-granule derived protein; bactericidal for common infective endocarditis pathogens; the protein plus oxacillin exert a synergistic bacterial effect
platelet protein P47: platelet granule constituent, mw 47,000, phosphorylated during degranulation of human platelets; refseq nm_002664 (human), nm_019549 (mouse)
platelet receptor for type III collagen, human: mw 68-72 kda; platelet receptor involved in platelet interaction with type iii collagen, localized within platelet lipid rafts where it could interact with other platelet receptors for collagen (gp vi and alpha2beta1 integrin) for efficient platelet activation
platelet's adhering protein, Bos taurus: collagen binding protein isolated from bovine platelet membrane; mw 75,000; consists of identical 4 subunits held by disulfide bridges; different from fibronectins
platelet-derived growth factor A: the a chain of platelet-derived growth factor; can exist as the homodimer pdgf-aa; has been sequenced; refseq nm_008808 (mouse), nm_033023 (human), nm_012801 (rat)
platelet-derived growth factor AB: a heterodimer; a pdgf isoform (the 2 other isoforms are the homodimers pdgf-aa and pdgf-bb); previous to 10/95, pdgf-ab has been indexed as platelet-derived growth factor
platelet-derived growth factor C: member of pdgf/vegf family of growth factors; ligand for pdgf-alpha receptor; amino acid ; refseq nm_016205 (human), nm_019971 (mouse), nm_031317 (rat)
platelet-derived neutrophil chemotactic peptide: from human platelets lysates; induces chemotaxis of human neutrophils; shows structural homology to platelet factor 4; n-terminal amino acid sequence given in first source
platenolide I: from streptomyces platensis; rn & n1 from 9th ci; see also platenolide ii: 52212-95-0
platenolide II: rn & n1 from 9th ci; see also platenolide i: 52212-94-9
platenomycin s: produced by streptomyces platensis malvinus mcrl 0388; cpd not in chemline 7/19/83
platensimycin: has antidiabetic and antisteatotic activities; a pentacyclic ketolide (structurally similar to adamantane) connected by an amide bond to 3-amino-2,4-dihydroxybenzoic acid; inhibits cellular lipid biosynthesis; discovered while screening compounds from streptomyces platensis bacteria in a south african soil sample with s. aureus bacteria deficient in fabf protein
platinated 2'-deoxyguanylyl-(3'--5')-3'-deoxyguanosine: rn given refers to (sp-4-3)
platinum chloride: rn given refers to cpd with unspecified mf; : k2ptcl; see also platinum tetrachloride
platinum diamino-4-methylpyridine chloride: cis-isomer is the active cpd
platinum propylenediamine dichloride: rn given refers to (sp-4-3)-isomer
platinum pyrimidine greens: inhibits the dna synthesis of tumor cells in the s phase of the cell cycle
platinum transferrin: physiologically active platinum transferrin complex; may be a nontoxic treatment for breast cancer
platinum(II) (1,2-cyclohexanediamine)(2-hydroxy-4-oxo-2-pentenoate): ; showed moderate activity against murine leukemia l1210 in mice and high activity against cisplatin-resistant l1210 leukemia
platinum(II) 1,2-diaminocyclohexane bis(glucuronate): rn given refers to (sp-4-2-(1r-trans))-isomer
platinum(II) 1,2-diaminocyclohexane glucuronate: rn given refers to cpd without isomeric designation
platinum(II) 1,2-diaminocyclohexane malonate: rn given refers to (sp-4-2-(trans))-isomer
platinum(II) bis(cyclopropylamine)-1,3-dithiol-2-ylidenemalonate: have shown potent antitumor activity against leukemia l1210 cells
platinum(II) octaethylporphine ketone: a phosphorescence quenching dye
platinum(II) tetrakis(N-methyl-4-pyridyl)porphyrin: a dna intercalating agent
platinum-metallothionein complex: taken up in proximal tubular cells of rat kidney; causes nephrotoxicity
platomycin: members of phleomycin-bleomycin family; cpd not in chemline 7/19/83
platycodigenin 3-O-(glucopyranosyl-(1-3)-glucopyranosyl)-28-O-(apiofuranosyl-(1-3)-xylopyranosyl-(1-4)-rhamnopyranosyl-(1-2)-arabinopyranoside): isolated from platycodon grandiflorum
platycodin: from platycocon grandiflorum; also see platycodin d & d3
platycodin D: triterpenoid saponin from a root of platycodon grandiflorum; rn refers to (2beta,3beta,16alpha)-isomer
platycodin D3: from the root of platycodon grandiflorum (campanulaceae)
platyconic acid: from platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo
platyconic acid B lactone: antiproliferative triterpenoid saponin from roots of platycodon grandiflorum
platycoside D: triterpenoid saponin from platycodon grandiflorum
platycoside E: triterpenoid saponin from platycodon grandiflorum
platyphylline: from senecio platyphyllus; rn given refers to (1 alpha)-isomer
platyphyllonol-5-O-beta-D-xylopyranoside: from the bark of black alder, inhibits the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells
platyphylloside: from the bark of black alder, inhibits the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells
platyphylloside 1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-glucopyranoside: a protective agent isolated from the bark of black adder, alnus glutinosa
plaunotol M-4: rn given for (e,e,z,e)-isomer
plaunotol M-6: rn given for (e,z,e)-isomer
plauracin: macrocyclic depsipeptide antibiotic related to virginiamycin & mikamycin
plebeiolide C: from salvia plebeia, inhibit il-6-induced stat3 activation
plecanatide: a uroguanylin analog and guanylate cyclase (gc-c receptor) agonist that activates receptors on gut epithelial cells to maintain barrier function, mucus production, and suppress inflammation. it is used in the treatment of chronic idiopathic constipation and other gastrointestinal disorders
plectasin: showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by s. pneumoniae
plectosphaeroic acid A: from a marine isolate of the fungus plectosphaerella cucumerina
plectosphaeroic acid B: from a marine isolate of the fungus plectosphaerella cucumerina
plectosphaeroic acid C: from a marine isolate of the fungus plectosphaerella cucumerina
plectranthoic acid: an amp-activated kinase activator with antineoplastic activity
plectranthol A: from plectranthus nummularius (labiatae)
plectranthol B: from plectranthus nummularius (labiatae)
plectranthroyleanone A: isolated from methanol extract of the whole plant of plectranthus africanus; has antibacterial properties
plectranthroyleanone B: isolated from methanol extract of the whole plant of plectranthus africanus; has antibacterial properties
plectranthroyleanone C: isolated from methanol extract of the whole plant of plectranthus africanus; has antibacterial properties
plectrinone A: inhibitor of h/k-atpase isolated from plectranthus barbatus andrews (lamiaceae)
plectrodorine: monoterpene alkaloid from plectronia adorata (rubiaceae)
pleiotrophin: mw 18 kda; developmentally regulated protein that induces mitogenic & neurite outgrowth activity; rn refers to human protein; refseq nm_017066 (rat); nm_008973 (mouse); nm_002825 (human)
plekhg5a protein, zebrafish: required for angiogenesis; has been sequenced; refseq xm_001923778
plekhh2 protein, rat: a podocyte-associated protein; refseq nm_001191770
pleofungins: antifungal cyclicdepsipeptides isolated from phoma sp
pleosporalone A: azaphilone from a marine-derived pleosporales sp. fungus
pleosporone: has antibacterial activity; isolated from staphylococcus aureus
plerixafor: a bicyclam derivate, highly potent & selective inhibitor of hiv-1 & hiv-2
plerocercoid growth factor: human growth hormone analog from plerocercoids of spirometra mansonoides
plesiocin: a synthetic, cross-linked version of psna2 with protease inhibitory activity
pleurocidin: isolated from the skin secretions of the winter flounder pleuronectes americanus; amino acid
pleurosine: catharanthuseus alkaloid; rn from 10th ci, chem subs index for (3'alpha,4'alpha)-isomer
pleurospiroketal A: from the edible mushroom pleurotus cornucopiae
pleurotolysin B, oyster mushroom: 59 kda protein that forms transmembrane pores
plexA protein, Drosophila: neuronal, class i semaphorin receptor; controls axon guidance; genbank af106932
plexB protein, Drosophila: neuronal, class i semaphorin receptor
plexin: a neuronal cell surface protein involved in the formation of retinal plexiform layers in xenopus; recognized by the monoclonal antibody, mabb2; mw 220 kda
plg-1 protein, C elegans: the plugging polymorphism results from the insertion of a retrotransposon into an exon of a novel mucin-like gene, plg-1, whose product is a major structural component of the copulatory plug
plicatic acid: major non-volatile fraction in red cedar dust; identified by inhalation challenge as allergen; rn given refers to (1s-(1 alpha,2 alpha,3 beta))-isomer
plicatin A: lipoxygenase inhibitory sphingolipid from chrozophora plicata
plicatin B acrylate: isolated from the medicinal plants psoralea juncaea and p. plicata
plicatin B sphingolipid: lipoxygenase inhibitory sphingolipid from chrozophora plicata
plipastatin: cyclic acylated decapeptide; phospholipase a2 inhibitors from bacillus cereus
plitidepsin: a cyclodepsipeptide isolated from aplidium albicans; has a pyruvoyl-proline residue instead of the lactyl-proline residue found in the linear peptide moiety of didemnin b
plk4 protein, Xenopus: refseq nm_001089677.1
pll protein, Drosophila: amino acid sequence given in first source; required for nuclear import of dorsal protein in order to establish dorsoventral polarity in drosophila embryos
plnA protein, Lactobacillus plantarum: a 366-bp fragment shows 95% identity with pln locus of lact. plantarum c-11; amino acid
plocamadiene A: halogenated terpene from red alga plocamium cartilageneum affecting neural transmission
plocamenol A: from the red alga plocamium cartilagineum (plocamiaceae)
plocamenol B: from the red alga plocamium cartilagineum (plocamiaceae)
plocamenol C: from the red alga plocamium cartilagineum (plocamiaceae)
plpA protein, Synechocystis sp. PCC 6803: a light-sensing histidine kinase from synechocystis sp. pcc 6803
pls protein, Pyrococcus furiosus: hyperthermostable serine protease from the archaeon, pyrococcus furiosus; amino acid ; genbank u55835
plsX protein, E coli: fatty acid/phospholipid synthesis protein; amino acid
plumbemycin A: isolated from streptomyces plumbeus; an l-threonine antagonist
plumbemycin B: isolated from streptomyces plumbeus; an l-threonine antagonist
plumericin: from bark of plumeria rubra; ; rn given refers to (3as-(3e,3aalpha,4abeta,7abeta,9ar*,9bbeta))-isomer; rn for cpd without isomeric designation not avail 5/91
plumieride: rn refers to (1s-(1alpha,4aalpha,7alpha(r*),7aalpha))-isomer; from allamanda cathartica & himatanthus fallax
plumisclerin A: isolated from the soft coral plumigorgia terminosclera
pluracidomycin: from streptomyces pluracidomyceticus; carbapenem antibiotic
plurivittaside: acetone extract of ferula plurivitta shown to be a benzo-gamma-pyrone glycoside
plusbacin A3: inhibits peptidoglycan synthesis in staphylococcus aureus
plutonium citrate: rn given refers to 2:1 citric:pu(4+) salt
plutonium dioxide: rn given refers to cpd with mf of pu-o2
plutonium nitrate: rn given refers to cpd with mf of pu-hno3
plx protein, Drosophila: a drosophila adhesion molecule belonging to a family of proteins expressed in plants, yeast, nematodes & man; amino acid sequence given in first source; genbank u50542
plxna4 protein, zebrafish: a class iii semaphorin receptor; genbank ab103158
plxnd1 protein, zebrafish: an endothelial receptor; genbank ay648302
pmARC-2 protein, Arabidopsis: marc - mitochondrial amidoxime reducing component
pmc4 protein, S pombe: mediates transactivation of rna polymerase ii promoters; component of mediator complex
pmd1 protein, S pombe: structural & functional counterpart of mammalian mdr proteins; amino acid sequence given in first source
pmi protein, Streptomyces viridochromogenes: aconitase-like enzyme involved in synthesis of phospinothricin tripeptide by streptomyces viridochromogenes
pmr-1 protein, C elegans: a p-type ca2+/mn2+ atpase, is expressed in hypodermal seam cells, intestinal cells and spermatheca; refseq nm_001026689.3
pmrA protein, Aspergillus niger: a homol of yeast pmr1; genbank af232827
pmrA protein, Bacteria: amino acid sequence given in first source; genbank l13395 (s. typhimurium)
pndA protein, E coli: kills plasmid-free segregants by interfering with a vital function in the cell membrane; involved in cell mg(2+) release and stable rna degradation; isolated from plasmid r483 & plasmid r16; has been sequenced; homologous to hok protein as well as srnb protein both from e. coli
pneumadin: lung peptide which triggers antidiuresis; the rat peptide begins with tyr and the peptide from human fetal lungs has ala instead of tyr
pneumocandin D(0): a potent inhibitor of pneumocystis carinii
pneumococcal polysaccharide type 17A: a serotype in the 23-valent ps vaccine
pneumococcal polysaccharide type 17F: a serotype in the 23-valent pneumococcal ps vaccine; carbohydrate sequence known
pneumococcal polysaccharide type 6: isolated from streptococcus pneumoniae; serotypes 6a & 6b are important causes of infections; pneumococcal type 6b conjugate vaccines elicit antibodies that cross-react with type 6a, not all anti-6b antibodies are functionally cross-reactive
pneumococcal polysaccharide type 9V: a linear polymer of pentasaccharide repeating units consisting of d-glucuronic acid & glucose
pneumococcal polysaccharide, type 8: isolated from streptococcus pneumoniae; carbohydrate
pneumococcal purpura-producing principle: high mw peptidoglycan from streptococcus pneumoniae
pneumococcal surface protein A: present on nonencapsulated & some encapsulated strains; monoclonal antibodies against it can protect mice from fatal pneumococcal infection
pneumoxide: consists of 5% carbon dioxide, 94% oxygen & 1% nitrogen; affects na,k atpase
png protein, Drosophila: inhibits the s phase and promotes mitosis; isolated from drosophila; do not confuse with png gene product; refseq nm_058144
pnr protein, Drosophila: regulates achaete and scute genes; has been sequenced
pnt protein, Drosophila: the pointed gene encodes two ets-like proteins (p1 & p2), involved in the development of the midline glial cells; amino acid sequence given in first source
pnut protein, Drosophila: required for cytokinesis in drosophila, similar to yeast bud neck filament proteins; may also play a role in cellularization; 539 amino acid residues, mw 60 kda; amino acid sequence given in first source; refseq nm_057716
pnx protein, zebrafish: a posterior neuron-specific homeobox gene that regulates posterior neurogenesis; amino acid
poaefusarin: metabolite of fusarium thought to be the cause of septic angina in ussr
pobilukast: a leukotriene receptor antagonist; an antiasthmatic agent; ; rn refers to (r-(r*,s*)-isomer
pochonin A: hsp90 inhibitor from fermentation broth of pochonia chlamydosporia
podacycline A: a cyclic nonapeptide; isolated from the latex of jatropha podagrica
podacycline B: a cyclic heptapeptide; isolated from the latex of jatropha podagrica
podj protein, Caulobacter crescentus: the polar organelle development gene podj, is expressed during the swarmer-to-stalked cell transition of the caulobacter crescentus cell cycle; amino acid
podocalyxin: the glomerular polyanion comprises all anionic sites of glomerular cell surfaces, basement membranes and extracellular matrix; refseq nm_013723 (mouse); nm_005397 (human)
podocalyxin-like protein 1, Oryctolagus cuniculus: a transmembrane core glycoprotein from rabbit glomerulus; has many of the characteristics of podocalyxin; genbank u35239
podocan protein, mouse: a small leucine-rich repeat protein; genbank ay313606
podocarpinol: reduced derivative of podocarpic acid with weak oestrogenic activity
podoendin protein, rat: podocyte fuzzy coat protein; also found on the endothelial cell surface; cell differentiation-dependent surface protein; mw 62,000
podolactone A: norditerpene lactone isolated from podocarpus nerifolius with potential activity against development in the housefly; see also records for podolactone e & podolactone c
podolactone C: norditerpene lactone isolated from podocarpus nerifolius with potential activity against development in the housefly; see also records for podolactone e & podolactone a
podolactone E: norditerpene lactone isolated from podocarpus nerifolius with potential activity against development in the housefly; see also records for podolactone a & podolactone c
podolide: antileukemic norditerpene lactone from podocarpus gracilior
podoscyphic acid: ; inhibitor of avian myeloblastosis virus & moloney murine leukemia virus reverse transcriptase;from a podoscypha species
podosporapepsin: from filamentous fungus p. anserina upon carbon starvation; genbank af016054
podoverine A: a microtubule destabilizing agent isolated from podophyllum versipelle
poecillastrin A: polyketide-derived macrolide lactam, was isolated from a deep-water collection of the marine sponge poecillastra species
poecillastrin B: macrolide lactam from the deep-water caribbean sponge poecillastra species
poecillastrin C: macrolide lactam from the deep-water caribbean sponge poecillastra species
poecillastrin D: cytotoxin from marine sponge jaspis serpentina
pohlianin C: has antimalarial activity; isolated from the plant jatropha pohliana
pokeweed antiviral protein: ribosome inactivating protein from phytolacca; pap i from spring leaves, pap ii from summer leaves, pap-r from root, pap-s & s1 & s2 from seed;
pokeweed lectin C: from the roots of phytolaca americana; shows homology to chitin-binding proteins; has 126 amino acid residues; mw 13,747 da; amino acid sequence given in first source
pokeweed lectin D: rn refers to pokeweed root isoform 1; isoform d2 lacks c-terminal leu-thr residues; isolated from phytolacca americana; amino acid
pol protein, Rabbit endogenous retrovirus H: gene hrv-5 is an exogenous retroviral sequence in humans representing an infectiously acquired genome; amino acid sequence given in first source; genbank u46939 & u46940
pol-RFamide neuropeptides protein, Polyorchis penicillatus: rfamide - arg-phe-nh2; contains one copy of pol-rfamide i, 11 copies of pol-rfamide ii & one putative neuropeptide sequence; from hydromedusa polyorchis penicillatus; amino acid sequence given in first source; genbank l14777
polB protein, E coli: amino acid sequence has been determined; a promoter of the sos regulon; polb100 has glycine(401) replaced by aspartic acid