NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
pp40 protein, Human herpesvirus 5: protein isolated from infected chicken with sequence & biochemical properties similar to those of mad-3 i kappa b; specific inhibitor of nf-kappa b; amino acid sequence has been determined
pp75 protein, rat: undergoes tyrosine phosphorylation in response to oxidative stress; mw 75 kda; homologous to glucose-related protein 75, mortalin, pbp74 and hsp75 proteins; pp75 most likely represents the mature form of a hepatic member of the hsp75 family; partial amino acid sequence given in first source
ppan protein, Drosophila: drosophila gene required for larval growth; homologs from a wide variety of organisms; amino acid
ppargc1a protein, zebrafish: refseq xm_017357138.2
ppe1 protein, S pombe: a serine/threonine phosphatase from fission yeast with high homology to pp6; involved in cell shape control and mitosis; amino acid sequence given in first source
ppk protein, Drosophila: has been sequenced; refseq nm_057884
ppkA protein, Pseudomonas aeruginosa: serine/threonine protein kinase from pseudomonas aeruginosa that is highly and specifically inducible during infection of neutropenic mice; genbank af035395
ppl protein, Drosophila: homologous to subunit h of the glycine cleavage system; isolated from drosophila; amino acid ; do not confuse with ppl gene product; refseq nm_079473
ppp2r2a protein, Xenopus laevis: refseq nm_001090669
ppp2r3a protein, Xenopus: refseq nm_001089158
ppp2r3a protein, zebrafish: regulatory subunit of protein phosphatase 2
pps1 protein, Mycobacterium sp.: intein (protein intron)-containing protein isolated from mycobacterium leprae and mycobacterium tuberculosis; the protein undergoes a protein self-splicing that involves a post-translational excision of the intervening region (intein) which is followed by a peptide ligation; don not confuse with pps1 protein, saccharomyces, which is a protein-tyrosine phosphatase; has been sequenced; genbank u00013
ppxA protein, Photorhabdus luminescens: hemopexin-like protein isolated from photorhabdus luminescens; partial amino acid ; genbank ay004319
ppxB protein, Photorhabdus luminescens: a hemopexin-like protein isolated from photorhabdus luminescens; partial amino acid ; genbank ay004319
pqi5 protein, E coli: isolated from e. coli; amino acid ; has two subtypes, pqi5a protein and pqi5b protein; genbank x81561
pqn-59 protein, C elegans: refseq nm_058326.5
pqr620: 1,3,5-triazine derivative, mtorc1/2 inhibitor pqr620
pr1 protein, Metarhizium anisopliae: isolated from metarhizium flavoviride
pr12 protein, Potato virus M: isolated from potato virus m; genbank x57440
pr160 gag-pol precursor protein, Human immunodeficiency virus 1: mw 160 kda; encoded by both the viral pol gene and the upstream gag gene; has been sequenced
prM protein, Dengue virus type 3: amino acid sequence given in first source; sequences known for h87 and 1153 strains
prM protein, Flavivirus: isolated from many different flaviviruses; upon virus release, proteolytic cleavage of prm in acidic post-golgi vesicles leads to separation of prm-e heterodimer in m and e protein moieties; has been sequenced
prabotulinumtoxin A: originating from wild-type clostridium botulinum
pradimicin A: from actinomycete strain no. p157-2; has inhibitory effect against hiv in vitro
pradimicin FA 2: ; des-n-methyl analog of pradimicin fa-1; isolated from actinomadura hibisca
pradimicin FB: ; isolated from actinomadura spinosa; deglucosyl analog of pradimicin fl
pradimicin FH: 11-hydroxyl analog of pradimicin fa-1; from actinomadura verrucosospora
pradimicin H: 11-hydroxyl analog of pradimicin a; from actinomadura verrucosospora
pradimicin S: ; isolated from actinomadura spinosa; the 3'-o-(3''-o-sulfo-beta-d-glucopyranosyl) analog of pradimicin a
pradimicin-IRD: polycyclic antibiotic produced by the actinobacteria amycolatopsis sp
praecordin: ointment used as tranquilizing agent in angina pectoris; contains camphor, menthol, oil melissae, oil eucalyptus extract of capsicum, benzyl nicotinate, tinct crataegi, tinct valerianae
praelolide: diterpene lactone from gorgonian menella praelonga; molecular formula c28-h35-o12-cl
praeruptorin A: isolated frompeucedanum praeruptorum dunn. roots
praeruptorin C: isolated from root of peucedanum praeruptorum dunn; rn from toxlit
pralidoxime: rn given refers to parent cpd; chloride was minor descriptor (75-80); on-line & index medicus search pralidoxime compounds (66-80)
pralnacasan: nsaid, ice inhibitor & metastasis inhibitor; rn &
pramiconazole: has antifungal activity; r-126638 is the (2s-cis)-isomer
pramiverine: long acting cholinolytic proposed for gastrointestinal spasms; minor descriptor (78-84); on-line & index medicus search cyclohexylamines (78-84); rn given refers to parent cpd
pranferol: isolated from maquira calophylla; rn given refers to (-)-isomer
pranlukast: srs-a antagonist; leukotriene d4 receptor antagonist
prasinon A: metabolite of streptomyces prasinus; delta potent insecticide against sheep blowfly larva
prasinon B: metabolite of streptomyces prasinus; potent insecticide against sheep blowfly larva
prasinoxanthin: from dinoflagellates, lepidodinium chlorophorum and l. viride
pratosine: a pyrrolophenanthridine alkaloid; a tetracyclic lactam; isolated from amaryllidaceae sp.
pravadoline: interact with a g-protein coupled receptor which is distinct from several known g-protein coupled receptors; rn given refers to parent cpd
prazocillin: rn given refers to (2s-(2 alpha,5 alpha,6 beta))-isomer
pre-B lymphocyte gene 1 protein, mouse: an immunoglobulin constant region-like peptide that is a component of surrogate light chain which associates with mu ig heavy chain to form pre b cell receptor
pre-B lymphocyte gene 2 protein, mouse: an immunoglobulin constant region-like peptide that is a component of surrogate light chain which associates with mu ig heavy chain to form pre b cell receptor
pre-B lymphocyte protein 3, human: a possible alternate partner subunit for the 2nd type of pre-b-cell receptor, i.e., alternate to surrogate light chain components
pre-T cell receptor alpha: a glycosylated type 1 membrane protein; mw 33 kda; covalently associates with tcrbeta; amino acid sequence given in first source; genbank u16958 (mouse); refseq nm_011195 (mouse), nm_138296 (human)
pre-aurantiamine: from the marine-derived fungus aspergillus aculeatus
pre-hemoglobin A, glycosylated: in children with insulin dependent diabetes mellitus
pre-kinamycin: intermediate in the biosynthetic pathway of kinamycin d; isolated from streptomyces murayamaensis
pre-prodynorphin: characterized; contains 256 amino acid residues; opioid peptide
pre-ribosomal RNA endoribonuclease: substrate is pre-rrna
pre-schisanartanin P: from the stems and leaves of schisandra viridis
preMBP protein, E coli: contains 396 amino acid residues; from e coli
preS (120-145) peptide: a synthetic lipophilic hepatitis b virus peptide fragment; elicits immune response; amino acid sequence given in first source
preadrenodoxin: mw 22,000d, appx 10,000d larger than mature adrenodoxin
prealbumin, Ile(122)-: abnormal prealbumin; ile substituted for val at position 122; found in patient with systemic senile amyloidosis
preaustinoid A: solated from the root bark of melia azedarach and cultivated over sterilized rice
preaustinoid B: solated from the root bark of melia azedarach and cultivated over sterilized rice
precarthamin: precursor of carthamin; isolated from the petals of carthamus tinctorius
precarthamin decarboxylase: catalyzes the oxidative decarboxylation of precarthamin to carthamin
precartilage protein 35.5: mw 35.5-kda; non-histone protein family from nuclei of precartilage mesenchyme cells; component phosphorylated during early chondrogenesis
precirol: octadecanoic acid esters; 2,3-dihydroxypropyl ester mixed with 3-hydroxy-2-((1-oxohexadecyl)oxy)propyl octadienoate & 2-((1-oxohexadecyl)oxy)-1,3-propanediol; auxiliary in tableting; alpha glycerol palmitostearate
preclamol: centrally acting dopamine receptor agonist with selectivity for autoreceptors
precocene I: cpd not in chemline 7/20/83; structure; inhibits juvenille hormones
precocene II: has antibacterial, antifungal, insecticidal, and antioxidant activities; from plants of genus ageratum; an antiallotropin compound capable of inhibiting juvenile hormone biosynthesis
precorrin 6x: metal-free precursor of the corrin macrocycle retaining five s-adenosylmethionine-derived peripheral methyl groups
precorrin 6x oxidoreductase: catalyzes nadph-dependent reduction of precorrin-6x to precorrin-6y; involved in vitamin b12 synthesis in pseudomonas denitrificans
precorrin-2 O-methyltransferase: catalyzes the c-20 methylation of precorrin-2 to precorrin-3
precorrin-3 11-methyltransferase: one of enzymes involved in hydrogenobyrinic acid synthesis; 11 aa amino-terminal sequence given in first source
precorrin-4 methyltransferase, E coli: catalyzes the coversion of precorrin-4 to precorrin-5
precorrin-5 methyltransferase, bacteria: catalyzes conversion of precorrin-5 to precorrin-6x; cobf isolated from e. coli; has both deacetylase and methyltransferase activities
precorrin-6 decarboxylase, E coli: catalyzes the conversion of precorrin-6y to precorrin-8x; has both methyltransferase and decarboxylase activity
precorrin-6 reductase: catalyzes reduction of precorrin-6x to precorrin-6y
precorrin-6 reductase, E coli: catalyzes reduction of precorrin-6x to precorrin-6y
precorrin-8w methyltransferase: a precorrin methyltransferase that catalyzes the decarboxylation, does not have the canonical precorrin methyltransferase fold; from methanobacterium thermoautotrophicum
precorrin-8x methylmutase, Thermoplasma acidophilum: catalyzes conversion of precorrin-8x to hydrogenobyrinic acid; genbank al445065
prednazoline: combination of 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-(di-h phosphate) and 2-((2-isopropylphenoxy)methyl)-2-imidazoline
prednefrin: topical ophthalmic solution combination of prednisolone phenylephrine
preflagellin: peptide that results when 11- or 12-amino acid leader peptides are cleaved prior to incorporation of the flagellin into the growing filament; has been sequenced
prefoldin: prefoldin transports unfolded proteins to cytosolic chaperonin (c-cpn); it consists of subunits pfd1-pfd6; refseq nm_002622 (pfdn1, human); nm_011070 (pfdn2, mouse); nm_012394 (pfdn2, human); nm_002623 (pfdn4, human)
pregestimil: a hypoallergenic infant formula in which casein hydrolysates replaces protein
pregna-1,4-diene-11-ol-3,20-dione: rn given refers to 11beta-isomer in chemline; rn for unspecified isomer not in chemline 7/11/83
pregna-4,17-diene-3,16-dione: steroid from guggulu extract; rn & n1 from c1 form index; rn given refers to cpd without isomeric designation; ; antagonist of farnesoid x receptor
pregna-7-en-3,11,15,20-quadriol: from poria cum radix pini
pregnancy protection protein P4: alpha-globulin mw 200,000; present in serum of pregnant women; natural inhibitor of cellular cytotoxicity reaction
pregnancy serum protein PSP60: 60-kda protein; produced by the placenta of cows; has been sequenced (inra patent fr 88 03590 filed 3-18-88)
pregnancy specific glycoprotein 18: secreted by mouse placenta; induces il-10 expression in murine macrophages; member of the psg family; amino acid
pregnancy-associated alpha 1-glycoprotein, rat: major secretory protein product of endometrium; a 32 kd insulin-like growth factor binding protein
pregnancy-associated esterase: in baboons, amount of activity correlates with stage of pregnancy; hydrolyzes alpha-naphthyl butyrate in preference to alpha-naphthyl acetate
pregnancy-associated glycoprotein 2: proteolytically active; amino acid sequence given in first source; genbank l34361
pregnancy-associated growth factor: from crude human chorionic gonadotropin obtained from pregnancy urine; mw 18,000-22,000; stimulates cultured peripheral blood lymphocytes
pregnancy-associated leporine protein, rabbit: mw for palp-2 is 45,000; species specific to rabbit; do not confuse with pyridoxal-5-phosphate which is also known as palp
pregnancy-associated murine protein 1: glycoprotein with mw l40,000 & isoelectric point of 4.2; significantly increased in serum during pregnancy but declines in concentration after mid-pregnancy; immunologically similar to human pregnancy zone protein (pzp, sp-3, alpha 2-pag)
pregnancy-associated murine protein 2: mw 70,000; immunologically similar to the pregnancy-specific beta 1-glycoprotein in human
pregnancy-associated murine protein 3: glycoprotein with mw 65,000 & isoelectric point of 4.1; present in male & non-pregnant mice in small amounts, but in greatly elevated amount in pregnant mice
pregnancy-specific beta-1-glycoprotein 12: a pregnancy-associated protein produced by the human placenta; belongs to the immunoglobulin superfamily; has been sequenced
pregnancy-specific beta-1-glycoprotein 7: a pregnancy-associated protein; expressed in human fetal liver; belongs to the carcinoembryonic antigen (cea) gene family of the immunoglobulin superfamily; amino acid sequence given in first source
pregnancy-specific glycoprotein (baboon): a placental glycoprotein, member of the pregnancy-specific glycoprotein family; amino acid
pregnancy-specific glycoprotein 17, mouse: binding of pregnancy-specific glycoprotein 17 to cd9 on macrophages induces secretion of il-10, il-6, pge2, and tgf-beta1
pregnancy-specific protein D1: from decidual tissue of pregnant women; mw 50,000-55,000; ph 5.6-6.0
pregnancy-specific protein D2: from decidual tissue of pregnant women; mw 150,000-160,000; ph 5.6-6.0
pregnane-3,17-diol-11,20-dione: induces delta-aminolevulinic acid synthetase in chick embryo & rat liver; rn given refers to cpd without isomeric designation
pregnant specific uterus protein, PSUP: a novel mouse gene expressed in pregnant uterus; homologs rat; expressed uterus,duodenum ; amino acid
prehispanolone: from chinese medicinal herb leonurus heterophyllus; ; platelet activating factor antagonist
preimplantation factor, human: a 15-mer peptide secreted by viable embryos and expressed in the placenta
preimplantation factor, mouse: a peptide secreted by viable embryos; required during pregnancy
prekininogens: amino acid sequence of both high & low molecular weight prekininogens given in first source
prel protein, Drosophila: a member of the preli/msf1p' family; refseq nm_136643
prelamin A: expression of prelamin a confers sensitivity to inhibition of dna biosynthesis by lovastatin on f9 cells; sequence known
prelamin A endoprotease: catalyzes conversion of 74-kda lamin a precursor to 72-kda lamin a; dependent on farnesylation
prelox: a vasodilator agent used to treat erectile dysfunction; consists of pine bark extract (pycnogenol) and l-arginine aspartate
prelycopersene pyrophosphate: 40-carbon terpene; biosynthetic product of squalene synthetase
premarrubiin: rn given for (2''as-(2''aalpha,5''abeta,6''alpha(s*),7''alpha,8''aalpha,8''balpha))-isomer
premnaspirodiene synthase: catalyzes the conversion of farnesyl pyrophosphate to premnaspirodiene
premnone A: cytotoxic clerodane diterpenoid from the leaves of premna tomentosa
premnone B: cytotoxic clerodane diterpenoid from the leaves of premna tomentosa
premnone C: cytotoxic clerodane diterpenoid from the leaves of premna tomentosa
preneocarzinostatin: neocarzinostatin-related protein, produced at same time by streptomyces carzinostaticus, which antagonizes activity of neocarzinostatin
prenostodione: an uv-absorbing metabolite from a natural bloom of the cyanobacterium nostoc species
prenyl caffeate: ; formed in the bud excretion of poplar species; major contact allergen in bee-glue
prenyl diphosphate synthase, subunit 2, human: refseq nm_020381.3; np_065114.3
prenyl-alpha-elemenone: lobane diterpenoid isolated from a population of bomean soft coral sinularia sp
prenyl-cysteine methyltransferase: carboxyl-methylates prenylated cam53 protein
prenylated methylated protein methyl esterase, rat: hydrolyses the prenylated protein methyl esters, thus making this step reversible and possibly regulatory
prenylated peptide-specific endoprotease: cleaves c-terminal tripeptide from prenylated protein having c-terminal sequence caax; race is rac and a-factor converting enzyme with same activity
prenylcysteine lyase: an fad-dependent thioesther oxidase that is involved in prenylcysteine metabolism in mammalian cells
prenyldiphosphate synthase, subunit 1, human: pdss1 mutations in ubiquinone deficiency are involved in oxidative phosphorylation disorders; refseq nm_014317.3; np_055132.2
prenylin protein, mouse: a golgi protein that may be involved in regulation of prenylated proteins; genbank af252856
prenylterphenyllin: an antineoplastic antibiotic; isolated aspergillus candidus
prepacol: contains sodium monohydrogen phosphate, sodium dihydrogen phosphate & bisacodyl; used to cleanse colon for double-contrast study
preparation B 100: combination of o-cymol & o-mentha-1,4-diene
prepenicillinase: precursor of penicillinase (ec 3.5.2.6)
prephenate aminotransferase: from tobacco; forms l-arogenate (intermediate precursor of tyrosine and phenylalanine); l-aspartate and l-glutamate are only amino-donors
prephenic acid: nonaromatic biosynthetic intermediate, probable immediate precursor of aromatic systems such as phenylalanine, tyrosine, tannins, flavanoids; isolated from cultures of mutant e coli
prephenoloxidase-activating enzyme: activates inactive phenol oxidase (ec 1.10.3.1); occurs in larval cuticle of silkworms, other insects, & lobster shells; also has esterase activities
prephyson: standardized extract of the anterior lobe of the pituitary gland of swine
prepilin peptidase protein, Bacteria: necessary for posttranslational modification & assembly of pilin monomers into pilus organelles; functions as a prepilin leader peptidase; amino acid sequence has been determined
prepro-26RFa protein, human: has orexigenic activity; amino acid ; refseq nm_198180
prepro-THR (160-169) receptor: recognizes thyrotropin-releasing hormone-potentiating peptide; located on rat anterior pituitary membranes
prepro-gonad-inhibiting hormone: from lobster homarus americanus, also found in hamsters, mice, rats and birds; amino acid sequence given in first source
prepro-major basic protein homolog: 64% identical to human prepro-major basic protein; amino acid
prepro-orphanin FQ(141-157): a precursor peptide, corresponding to murine ppofq141-157; amino acid
prepro-orphanin FQ(160-187): from mouse, rat & human; amino acid
prepro-thyrotropin releasing hormone (160-169): pro-trh-connecting peptide; amino acid sequence given in first source
prepro-thyrotropin-releasing hormone (178-199): pro-trh-connecting peptide; amino acid sequence given in first source
preproabrin: from the seeds of abrus precatorius; consists of an a-chain of 251 amino acids preceded by 34 amino acids containing an n-terminal signal peptide, followed by a 14-amino acid linker & a b-chain of 263 amino acids; amino acid sequence given in first source
preproacrosin: amino acid sequence same as proacrosin except it contains a 15-amino acid leader sequence; located on chromosome 22
preproalbumin: compared to prealbumin, it contains 18 additional amino acids at the nh2 terminal
preproaprotinin: contains 100-amino acid residue with a signal peptide for translation into the endoplasmic reticulum; partial aa sequence given in first source
preproatrial natriuretic factor (104-123): increases renal guanylate cyclase activity; amino acid sequence given in first source
preproatrial natriuretic factor (26-55): increases renal guanylate cyclase activity; amino acid sequence given in first source
preproatrial natriuretic factor (56-92): increases guanylate cyclase activity; amino acid sequence given in first source
preprocalcitonin: calcitonin with 20 amino acid extension beyond carboxyl terminal proline
preprocalcitonin gene-related peptide: complementary to bases 311-350 of the respective mrna
preprocathepsin C: mw 51.8 kda; has 463 amino acid residues; amino acid sequence given in first source; genbank x87212
preprocecropin D protein, Hyalophora cecropia: from hyalophora cecropia; cecropins are antibacterial peptides; amino acid sequence given in first source
preproceruloplasmin: primary product of cell-free translation of ceruloplasmin messenger rna
preprocholecystokinin: from porcine cerebral cortex & duodenal mucosa; 114 amino acids
preproconopressin: from mollusc lymnaea stagnalis; vasopressin-related precursor; amino acid sequence given in first source
preproendothelin-3: amino acid sequence of rat preproet-3 given in first source
preprogastrin: contains primary amino acid sequence of big gastrin extended at both the n- and c-terminus
preproglobulin beta: consists of 21 amino acid residues given in first source; precursor protein of 11-s globulin betal subunit
preprohormone A: a hydra-rfamide preprohormone; amino acid
preprohormone B: a hydra-rwamide preprohormone; amino acid
preprohormone KVamide: a hydra-kvamide preprohormone; amino acid
preprohormone LWamide: a hydra-lwamide preprohormone; amino acid
preprohormone c: a hydra-rwamide preprohormone; amino acid
preproinsulin-like growth factor: amino acid sequence from atlantic hagfish given in first source
preproinsulin-like growth factor I: has 158 amino acid residues and an e-peptide sequence of 24 residues
preproinsulin-like growth factor II: 180-amino acid protein; from human liver
preprokallikrein: precursor of prekallikrein which is a precursor of tissue kallikrein ec 3.4.21.35
preproneurokinin-C, mouse: encoded by preprotachykinin-c (ppt-c) gene; has been sequenced
preproneuropeptide Y: neuropeptide tyrosine precursor; mw 12 kda; see also record for proneuropeptide y
preproparathormone: has an additional 25 peptide extension on the amino terminal end of proparathormone
prepropeptide GLa, frog: precursor to secretory protein containing 64 amino acids; processd by dog pancreas microsomes
preprorennin: precursor of prorennin, which is precursor of rennin (chymosin): ec 3.4.23.4
preprotachykinin: beta-preprotachykinin contains both substance p & substance k sequence; alpha-preprotachykinin contains substance p sequence only; gamma-preprotachykinin contains the sequence of both substance p and neurokinin a; delta-preprotachy kinin contains the sequence of substance p but not neurokinin a; refseq nm_009312 (mouse)
preprotachykinin B (50-79): amino acid sequence given in first source; found in both neurokinin b and preprotachykinin b
preprourokinase: consists of 431 amino acids, with the first 20 residues being a signal peptide
preprovasoactive intestinal peptide: after the signal sequence, contains 5 functional domains which are: n-terminal flanking peptide, 2nd biologically active peptide, a bridging peptide, vip, and a c-terminal flanking peptide
presclerotized eggshell protein, Fasciola hepatica: mw 31 kda; aa composition and sequence given; contains high levels of dopa and lysine; from liver fluke
presecamine: from amsonia elliptica; rn & nl from 9th ci; cpd not in chemline 8/18/83
presenegenin: rn given for (2beta,3beta,4alpha)-isomer
presenilin-alpha protein, Xenopus: isolated from brain; genbank d84427
presenilin-beta, protein, Xenopus: isolated from xenopus brain; amino acid ; genbank d84428
presenilinase, human: presenilin undergoes endoproteolysis by presenilinase to generate the functional n-terminal and c-terminal fragment heterodimers (ntf/ctf) that may harbor the gamma-secretase active site; presenilinase has characteristics of an aspartyl protease, but this activity is distinct from gamma-secretase
presequence protease PreP, Arabidopsis: degrades targeting peptides as well as other unstructured peptides in both mitochondria and chloroplasts
presphaerene: from the red alga sphaerococcus coronopifolius
prespore protein EB4-PSV, Dictyostelium discoideum: amino acid sequence known
prespore-specific antigen, Dictyostelium discoideum: amino acid sequence known; isolated from dictyostelium discoideum
presqualene alcohol: rn & n1 from 9th ci; cpd not in chemline 8/18/83
prestegane B: synthetic lignan; has diuretic & natriuretic properties; ; rn given refers to (3r-trans)-isomer
presulfophilin: consists of a signal peptide and amino-terminal amino acid of secretogranin ii, a glycine residue, 12 heptapeptide (eepeyge) units, and 3 carboxyl-terminal acid residues pro-gly-arg; mol wt 14,200 da; amino acid sequence given in first source
presurface protein 1, hepatitis B surface antigen: 226 amino acid product of hepatitis b virus s gene + 163 amino acids; may be important in virion assembly & infectivity
presurface protein 2, hepatitis B surface antigen: 226 amino acid product of hepatitis b virus s gene + 55 amino acids; may be important in virion assembly & infectivity
pretazettine: potent inhibitor of viral reverse transcriptase; narcissus alkaloid; prolongs life of leukemic mice; rn given refers to (6a beta,8 beta)-isomer
prethcamide: mixture of cropropamide & crotethamide used as respiratory stimulant & analgesic; major descriptor (66-85); on-line search aminobutyric acids (66-85); index medicus search prethcamide (66-85)
prethrombins: removal of profragment 1 from prothrombin leaves prethrombin 1; subsequent removal of profragment 2 leaves prethrombin 2; cleavage of an arg-ile bond in prethrombin 2 yields thrombin; rn given refers to cpd with unknown mf
pretomanid: nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial f420-depedent glucose-6-phosphate dehydrogenase (fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis
pretrichodermamide A: an unusually bridged epidithiodiketopiperazine from the fungus trichoderma sp.
pretyrosine dehydratase: pretyrosine is converted to phenylalanine
preuisolactone a: norsesquiterpenoid isolated from preussia isomera
preussiadin A: from the ascomycetous fungus preussia typharum
preussiadin B: from the ascomycetous fungus preussia typharum
preussochromone A: from an endolichenic fungus, preussia africana
preussomerin EG1: from the endophytic fungus edenia gomezpompae
preussomerin EG2: from the endophytic fungus edenia gomezpompae
preussomerin EG3: from the endophytic fungus edenia gomezpompae
preussomerin G: isolated from the fungi preussia isomera and harmonema dematioides
preussomerin I: rn given for (3r-(3alpha,3aalpha,8abeta,9abeta,9balpha))-isomer; isolated from the fungi preussia isomera and harmonema dematioides
prevezol C: first isolated from the organic extracts of the red alga laurencia obtusa
priA protein, Lentinus edodes: amino acid sequence given in first source; 258 amino acid residues, mw 26.7 kda; rich in ser, pro and thr residues; may play a role in the beginning of fruiting
pridinol: antispasmodic & muscle relaxant; rn given refers to parent cpd; structure in merck index, 9th ed, #7539
prieurianin: a limonoid from turraea obtusifolia that interferes with endocytosis in seedlings; ; rn refers to (alpha,4abeta,5beta,11beta,12alpha(2r,3r),13alpha,14beta,17alpha)-isomer
prim-O-glucosylcimifugin: from peucedanum dissolutum
primabond: consists of 4 components-triethyleneglycoldimethacrylate, aliphatic polyesterurethane acrylate, pentaerythriol and epoxysilane
primary biliary cirrhosis antigen 95k: a 95 kilodalton nuclear autoantigen in primary biliary cirrhosis
primase-reverse transcriptase complex: from halobacterium halobium; contains reverse transcriptase, dna polymerase & rnase h activities; synthesizes oligonucleotides (8-12) bases) that can be used as primer by e coli dna nucleotidyltransferase i
primase-stimulating factor: contains two polypeptide components of 146 kda and 47 kda; specifically stimulates primase; found in bovine thymus
primer activating enzymes: enzymes which convert gamma-ray induced lesions to effective priming sites (3'-oh terminals) for repair replication by dna polymerase
primextra: a commercial pesticide consisting of atrazine and s-metolachlor
primidolol: antihypertensive agent with both alpha & beta adrenoceptor blocking activity; rn & n1 from 9th ci form index; rn given refers to parent cpd; structure in ud 31;139f
primosiston: contains hydroxyprogesterone caproate & estradiol benzoate, note: primosiston is a multi-meaning drug name
primulic acid: rn given refers to (3 beta,16 alpha)-isomer
primuline: a fluorescent terbenzothiazole; do not confuse with a malvidin anthocyanin which sometimes uses a similar name; transported retrogradely through axons to the neuronal soma
prindamine: inhibits gastric secretion & motility; rn given refers to parent cpd
prinomastat: a diazepine-based hydroxamic acid inhibitor; matrix metalloproteinase (mmp) inhibitor; angiogenesis inhibitor;
prinomide: rn given from toxline; rn not in chemline 7/87
prinsepicyanoside A: antibacterial from the seeds of prinsepia utilis
prinsepiol-4-O-beta-D-glucopyranoside: lignan glycoside from the roots of valeriana prionophylla
prion protein (106-126): protease-resistant, amyloidogenic & neurotoxic peptide homologous to residues 106-126 of the prion protein
prion protein (121-231): a mouse prion protein domain; contains 3 alpha-helices and a 2-stranded antiparallel beta-sheet
prismane protein, Desulfovibrio vulgaris: a 52 kda novel iron-sulfur stable monomeric protein from sulfate-reducing bacterium desulfovibrio vulgaris (hildenborough); amino acid sequence known
pristanoyl-CoA oxidase: pristanoic acid undergoes beta-oxidation giving alternatively rise to acetyl-coa or propionyl-coa & h2o2
pristinamycin I synthetase: involved in pristinamycin 1 biosynthesis; includes at least 4 peptide synthetases involved in the activation and condensation of the pristinamycin i precursors - snba, snbc, snbd and snbe (pi synthetase 1, 2, 3, 4 respectively)
pristinamycin IIA synthase: a heterodimer of snaa & snab proteins (snaa & snab gene products, respectively); catalyzes the oxidation of piib to piia with fmnh2 and o2 as cofactors; from streptomyces pristinaespiralis; amino acid sequence and reaction given in first source; genbank u21215
pristinol: a sesquiterpene alcohol isolated from streptomyces pristinaespiralis
pritelivir: herpes simplex virus 1 helicase-primase inhibitor
prizidilol: rn given refers to parent cpd; synonyms prizidilol & sk&f 92657 refer to di-hcl
prlC protein, E coli: amino acid sequence given in first source; homologous to opda protein (oligopeptidase a); from e. coli
prmC protein, E coli: from escherichia coli; has 225 amino acid residues; genbank d28567
pro-AKAP82 protein, mammalian: precursor for the major sperm fibrous sheath protein akap82; similar to a-kinase anchoring proteins
pro-F-EGCG2: antitumor fluoro-substituted epigallocatechin gallate (egcg) analog
pro-F-EGCG4: antitumor fluoro-substituted epigallocatechin gallate (egcg) analog
pro-LHRH (14-69)OH: 56-residue peptide of pro-lhrh
pro-MMP-9 activator: a chymotrypsin-like proteinase
pro-OmpA nuclease A: a hybrid protein of staphylococcal nuclease a fused to the signal peptide of the ompa protein
pro-aldosterone secretion inhibitory factor: contains 103 amino acids; amino acid sequence given in first source
pro-alpha-2-plasmin inhibitor: the precursor contains a 12 amino acid leader peptide
pro-alpha1(V-XI) collagen: genbank ab045975 (alpha 1 type v/xi collagen)
pro-alpha3(V) collagen: amino acid ; genbank af176645 and af177941
pro-argin: consists of arginine, calcium carbonate, and sodium monofluorophosphate
pro-brain natriuretic peptide (1-76): amino-terminal pro-brain natriuretic peptide; marker of cardiac impairment
pro-calcitonin gene-related peptide: mw 12.5 kda; generates cgrp from the midregion as well as amino- & carboxy-terminal flanking peptides
pro-clotting enzyme: enzyme capable of causing the gelation of clottable proteins in horseshoe crab; activation of enzyme needs presence of calcium & endotoxin
pro-concanavalin A: converted to active lectin by deglycosylation; mr 33,500; from seeds of jackbeans; has been sequenced
pro-enkephalin-Leu: endogenous precursor to leu-enkephalin; see also record for proenkephalin
pro-gastrin-releasing peptide (31-98): a specific tumor marker in patients with samll cell lung carcinoma; has been sequenced
pro-growth hormone releasing hormone, mouse: contains 103 amino acids; amino acid sequence given in first source; see also record for prepro grf; refseq nm_010285 (for full-length ghrh)
pro-hepatocyte growth factor: single chain molecule from which the hgf molecule is formed by proteolytic cleavage at arg494-val495 site
pro-islet amyloid polypeptide: the precursor of the beta-cell peptide islet amyloid polypeptide (iapp) (amylin); amino acid sequence known
pro-macrophage stimulating protein convertase: catalyzes the cleavage of pro-msp to yield active msp
pro-nerve growth factor, human: ngf is synthesized as a precursor, prongf, which undergoes processing to generate mature ngf; prongf is abundant in central nervous system tissues and has been reported to have both apoptotic activity and neurotrophic activity
pro-nerve growth factor, mouse: ngf is synthesized as a precursor, prongf, which undergoes processing to generate mature ngf; prongf is abundant in central nervous system tissues and has been reported to have both apoptotic activity and neurotrophic activity
pro-ocytocin-neurophysin convertase: cleaves pro-ocytocin-neurophysin at the cooh-terminal side of arg 12 to release the bioactive peptide
pro-opiomelanocortin amino-terminal glycopeptide: has aldosterone-stimulating activity
pro-opiomelanocortin human joining peptide(77-109): see also related record pro-opiomelanocortin joining peptide(14-23)
pro-opiomelanocortin joining peptide(14-23): region between gamma-msh & acth; see also related record pro-opiomelanocortin human joining peptide(77-109)
pro-opiomelanocortin joining peptide(77-97): situated between gamma(3)-msh & acth; in rat & mouse preceeded by arg(76) & terminates with arg(97)
pro-phenol oxidase activating proteinase: a member of the prophenoloxidase activating factor (ppaf) family; isolated from manduca sexta; amino acid ; genbank af059728
pro-sigmaE protein, Bacillus subtilis: majority in cell lysates of sporulating cells is membrane-associated which may facilitate its proteolytic processing to activate sigma e
pro-sigmaK protein, Bacillus subtilis: majority in cell lysates of sporulating cells is membrane-associated and inhibits rna polymerase core binding, which may facilitate activating pro-sigma k; amino acid sequence known
pro-thyrotropin releasing hormone: found in rat brain; 5 amino acid sequence also in xenopus skin & bovine hypothalamus
pro-transforming growth factor-alpha processing protease: converts membrane-bound protgf-alpha to soluble tgf-alpha; mw 84 kda
proIslet peptide, human: a 14-mer peptide encoded by a portion of the reg3a gene
proOmpF-Lpp secretory protein, recombinant: hybrid secretory protein composed of the signal region of proompf & the mature part of the major lipoprotein; used to study the proton motive force required for translocationacross the cytoplasmic membrane of e coli
proacame: a derivative of natural estrogenic steroid with a 17-beta-amino-alcohol side chain; with no anti-platelet-aggregating effect
proacrosin: precursor of ec 3.4.21.10, acrosin
proaerolysin: a bacterial toxin that forms pores in host cells by oligomerization; protein precursor of aerolysin; amino acid sequence given in first source
proalbumin convertase, mammalian: requires ca++; cleaves normal human albumin from proalbumin; requires sequence arg-arg-asp and splits off the dibasic sequence
proalbumin endoproteinase: calcium-dependent endopeptidase from golgi membrane fractions of rat liver; ph optimum 6.0; specific for carboxyl side of paired basic residues (arg-arg & lys-arg) in proalbumin & proparathyroid hormone
proalbumin hexapeptide extension: hexapeptide at n-terminal end by which proalbumin differs from serum albumin
proalbumin pentapeptide extension: pentapeptide extension at n-terminal end of serum albumin
proangiotensin-12, rat: a 12-mer peptide that may be part of the renin-angiotensin system; amino acid
proanthocyanidin: rn given refers to proanthocyanidin a; cannabinoid receptor cb1 antagonist
proanthocyanidin B4: from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes
proatherocytin protein, Proatheris superciliaris: fosters platelet aggregation; partial amino acid
probable amylase-protease inhibitor-B, Oryza sativa: from rice; mw 9 kda; its function may be phospholipid transfer; amino acid sequence has been determined
probasin: androgen-dependent secretory proteins from rat dorsal prostate & coagulating gland; member of transglutaminase family
probestin: inhibitor of aminopeptidase m; from streptomyces azureus mh663-2f6
probon: proposed analgesic; minor descriptor (75-86); on-line & index medicus search pyrimidinones (75-86); rn given refers to parent cpd
probursin: tetradecapeptide; amino acid sequence given in first source; from bovine marrow & liver; amino acids 1-5 correspond to the active site of somatostatin, 5-8 to tuftsin & 9-11 to bursin
procaerulein: isolated from xenopus laevis and other frogs; amino acid
procalpain: calcium-dependent proteinase present in erythrocytes in inactive heterodimeric form containing a 80,000 & 30,000 subunit; see record for mu-calpain proenzyme for the 80,000 subunit
procamine: histamine-terminal peptide from venom of honeybee; rn is from 9th ci; cpd not in chemline 9/10/82
procarboxypeptidase A-S6: ternary complex consisting of procarboxypeptidase a-s6 plus a c-type chymotrypsinogen plus a defective serine endopeptidase like protein (subunit iii)
procarboxypeptidase E: precursor of ec 3.4.17.10
procardosin A: 64-kda cardosin a precursor that contains a plant-specific insert (psi)
procaricain: caricain is naturally expressed as an inactive zymogen (procaricain); contains an inhibitory proregion which consists of an additional 106 n-terminal amino acids; amino acid sequence of proregion given in first source
procasomorphin protein, Heliothis zea: isolated from the plant parasite heliothis zea; amino acid
procathepsin G: shows carboxyl-terminal prodomain of 11 amino acids which are not present in cathepsin g
processing enzyme 1, Vigna mungo: homologous to jackbean asparaginyl endopeptidase (legumain); a protease involved in the processing of the plant cysteine endopeptidase (sh-ep) 43-kda intermediate to the 36-kda intermediate
procinolol: rn given refers to parent cpd & from cas registry handbook, numbers section, 1965-1971
procion blue MX-R: used in affinity labeling of enzymes; rn given refers to parent cpd
procion brilliant orange M-2RS: rn given refers to tri-na salt & for procion brilliant orange 2rs; marker for identification of demineralized enamel in teeth
procirsin: an active aspartic protease precursor from cirsium vulgare (asteraceae)
proclavaminate amidino hydrolase: hydrolyzes guanidinoproclavaminate to proclavaminate; amino acid sequence given in first source
procoligenoids: heat-labile enterotoxins from e coli porcine & human strains heated & polymerized to high mw aggregates with accompanying loss of toxicity
procolipase activation peptide: n-terminal pentapeptide which is cleaved from procolipase in process of activation
procollagen Type III-N-terminal peptide: precursor-specific segments located at the amino end of procollagen
procollagen type I carboxy terminal peptide: elevated in alcoholic hepatitis & cirrhosis
procollagen type II carboxy-terminal peptide: marker of cartilage matrix metabolism in human joint fluid
procollagenase: precursor of ec 3.4.24.3, clostridiopeptidase a
procollagenase proactivator: metalloproteinase which converts procollagenase to active collagenase; amino acid sequence given in first source
proctofoam-HC: aerosol containing hydrocortisone acetate & pramoxine
procumbenoside A: isolated from the whole plant of justicia procumbens (acanthaceae)
procumbentin: an antiinflammatory and antinociceptive from the aerial parts of tridax procumbens
procumboside A: a cyclooxygenase-2 inhibitor; isolated from veronicastrum axillare
procurcumenol: rn given for (1s-(1alpha,3abeta,8aalpha))-isomer; epiprocurcumenol is the (1s-(1alpha,3aalpha,8aalpha))-isomer; a tnf-alpha antagonist isolated from curcuma zedoaria
procyanidin trimer C1: a flavonoid found in multiple plant sources including grape, apple, and cacao, which has antioxidant and anti-inflammatory properties
procyclic acidic repetitive protein, Trypanosoma: from multiple trypanosoma species; an invariant cell surface protein; do not confuse with parp protein (from collagen) or parp (abbreviation for poly adp ribose polymerase (mh))
prod protein, Drosophila: required for mitotic chromosome condensation and cell proliferation; mainly found in centromeres; amino acid ; refseq nm_166317
prodelphinidin B-2 3'-O-gallate: a proanthocyanidin gallate isolated from green tea leaf
prodelphinidin B2 3,3' di-O-gallate: from green tea
prodepin: an adrenomedullin gene product; rn given refers to human prodepin
prodigiosin condensing enzyme: condenses 2-methyl-3-amylpyrrole with 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde to form prodigiosin
prodigiosin r2: prodigiosin from the roseophilin producer streptomyces griseoviridis
proelastase: precursor of ec 3.4.21.11, pancreatopeptidase
proendothelin 1: a 195 amino acid residues inactive precursor produced upon removal of the signal peptide from preproendothelin-1 (212 residues); undergoes proteolysis to yield big endothelin (38 residues), which is an immediate precursor to endothelin (21 residues)
proendothelin-1 (22-39): peptide fragment of proendothelin-1 which contains 39 amino acids
proenkephalin: rn given refers to 5-pro-enkephalin; see also record for pro-met-enkephalin & pro-leu-enkephalin
proenkephalin carboxyl-terminal peptide B: 3.6kda, 31 amino acid carboxyl-terminal peptide b present in adrenal medulla proenkephalin is phosphorylated at multiple sites; amino acid sequence given in first source
profadol: was mh 1976-92 (see under pyrrolidines 1976-90); use pyrrolidines to search profadol 1976-92; a synthetic narcotic that acts like pentazocine, but with a sharp onset & short duration of action; used as an analgesic
profenamine: was heading 1972-94 (see under phenothiazines 1972-90); use phenothiazines to search ethopropazine 1972-94
profermin: a dietary supplement for those with ulcerative colitis; consists of fermented oats, lactobacillus plantarum, barley malt, lecithin and water
proferrorosamine A: produced by pseudomonas roseus fluorescens; rn given refers to parent cpd
profilactin: 1:1 complex between monomeric actin & profilin
proflamin protein, Flammulina velutipes: active against adenocarcinoma and melanoma in mice
progelatinase: mw 72 kda; tissue inhibitor of metalloproteinase-2 binds to stabilization site, thereby preventing autocatalytic activation & degradation but not gelatinolysis by the enzyme-inhibitor complex
progenipoietin-1: a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3; a potent mobilizer of hematopoietic stem cells
progestasert (progesterone-IUD): membrane enclosed reservoir inserted in uterus containing progesterone; once-a-year contraceptive; chemline gives progestasert as a synonym for progesterone
progesterone 11-glucuronide-alkaline phosphatase conjugate: 11 alpha-hydroxyprogesterone 11-glucuronide conjugated with alkaline phosphatase
progesterone 11-hemisuccinate: rn given refers to cpd without isomeric designation
progesterone 20-keto-reductase: rat liver microsome enzyme requires nadph to form the 20beta alcohol, also forms 20alpha oh using nadh
progesterone 3-(O-carboxymethyl)oxime-bovine serum albumin: used to ascertain the effects of progesterone at the plasma membrane; or as an antigen for anti-progesterone antibodies
progesterone 5 beta-reductase: a stereospecific enzyme; forms 5 beta-pregnane-3,20-dione from progesterone; see also progesterone 5 alpha-reductase
progesterone 6-hemimaleate: used in a radioimmunoassay for progesterone
progesterone 6-hemisuccinate: used in a radioimmunoassay for progesterone
progesterone-11-bovine serum albumin: modulates amphetamine evoked dopamine release
progesterone-11HS-horseradish peroxidase: used as a tracer in an immunoassay for progesterone
progesterone-3-(O-carboxymethyl oxime)-horseradish peroxidase: used as a tracer in an immunoassay for progesterone
progesterone-induced uterine protein-1, human: a product of secretory endometrial stromal cells; relative mol mass 70,000; isoelectric point 5.7
progestogen receptor 2, Anguilla japonica: progestogen receptor subtype in the testis of japanese eel, anguilla japonica; genbank ab028024
proglobeflowery acid: from leaves & stalks of trollius macropetalus
proglycosyn: ; proglycosyn is short for "promotes glycogen synthesis"
progonadoliberin I: decapeptide gonadorelin with 59 amino acid carboxy-terminal extension
progresin (Retard): combination drug: magnesium nicotinate & magnesium dehydrocholate; magnesium is important part of drug combination
prohaptoglobin: glycosylated primary translation product cleaved in biosynthesis of rat haptoglobin
prohead protease, bacteriophage T4: has been sequenced; p21 protein is autocatalytically cleaved to form t4 prohead protease; gene 21 also codes for p21s protein, expressed concomitantly with p21
proheparum: combination of vitamin b12, l-cysteine hcl, 2-hydroxy-trimethylethanaminium salt with 2,3-dihydroxybutanedioic acid, myo-inositol and liver extracts; used for the treatment of chronic hepatitis and liver cirrhosis
prohexadione-Ca: a 2-oxoglutarate-dependent dioxygenase inhibitor reduces the incidence and severity of fire blight caused by erwinia amylovora and other plant diseases
prohormone thiol protease: catalyzes the final step of (met)enkephalin sythesis in chromaffin granules
proinsulin endopeptidase I: involved in proteolytic conversion of proinsulin into insulin; ph optimum 5.5; cleaves exclusively on the c-terminal side of arg 31.arg 32 (b-chain/c-peptide junction); not inhibited by inhibitors of aspartic proteinases
proinsulin endopeptidase II: involved in proteolytic conversion of proinsulin into insulin; cleaves preferentially on the c-terminal side of lys 64.arg 65 of proinsulin (c-peptide/a-chain junction); ph optinum 5.5; not inhibited by inhibitors of aspartic proteinases
proinsulin, des-(23-63)-: amino acid sequence from pig given in first source
proinsulin-E. coli tryptophan E chimeric polypeptide: human proinsulin coupled at its amino terminus to portion of e coli tryptophan e gene product
proinsulin-like growth factor II: abnormal processing of pro-igf-ii takes place in patients with hepatoma & in some hepatitis b virus antibody-positive asymptomatic individuals
projectin: amino acid sequence has been determined; a large protein of insect muscles; similar to titin & twitchin
prokallikrein, tissue: precursor to tissue kallikrein (ec 3.4.21.35)
prokaryotic potassium channel: a 160 amino acid residues k+ channel from streptomyces lividans; amino acid sequence given in first source
prolactin 16-kDa fragment, human: 16-kda n-terminal fragment of human prolactin (16k hprl); a potent antiangiogenic factor that has been shown to prevent tumor growth in a xenograph mouse model
prolactin, polymeric: causes hyperprolactinemia; has substantially less biological activity than prolactin
prolactin-like protein B: has 44% homology to rat prl at the amino acid level; expressed in the antimesometrial cells of the artificially produced deciduoma in the pseudopregnant rat & by the homologous cells in the decidua during pregnancy
prolactin-releasing factor (placenta): mw 23.5kda; from placenta; stimulates the release of prolactin from human decidua
prolame: a derivative of natural estrogenic steroid with a 17-beta-amino-alcohol side chain, 3-hydroxypropylamine; exhibits estrogenic and anti-coagulation effects
proliferating cell marker 1 protein, rat: prom - proliferating cell marker; amino acid sequence known; 37 amino acid residues
proliferation arrest transcription factor, Coturnix japonica: a bzip protein involved in cellular proliferation arrest; genbank af395439
proliferation associated nuclear element 1 protein, mouse: expressed in the nucleus of non-confluenet cells; genbank ay243537
proliferation regulatory factors, human urine: composed of 3 molecules with mw 41,000, 7,800, & 5,100 named prf-i, -ii, -iii respectively; from normal human urine; stimulate growth of normal cells at optimum concentration & suppress growth of tumor cells
prolifix: contains the mitogenic compound gcr-1003; no further info available 10/2004
proline chloromethyl ketone: rn given refers to (l)-isomer; cpd not in chemline 7/21/83
proline transport protein: mw 100-kda peptide; facilitates transport of proline in cytoplasmic membrane vesicles; refseq nm_053996 (rat); nm_201353 (mouse)