NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
scytonemin: an ultraviolet sunscreen pigment from the sheaths of cyanobacteria
scytovirin protein, S varium: a potent anti-hiv protein, isolated from cultured cyanobacterium scytonema varium; amino acid
sd protein, Drosophila: do not confuse with segregation distorter protein, drosophila; has been sequenced; sd is a duplicate gene symbol in flybase; refseq nm_167465
sdf2l1 protein, mouse: is an endoplasmic reticulum stress-inducible gene and encodes a new member of the pmt/rt protein family; refseq nm_022324
sdhb-1 protein, C elegans: refseq nm_063591.6
sdiA protein, E coli: may activate transcription of ftsqaz cluster; similar to luxr; has been sequenced
sdk protein, Drosophila: member of immunoglobulin superfamily; required for pattern formation in eye; isolated from drosophila; amino acid ; refseq nm_057941
sds22 protein, S pombe: amino acid sequence given in first source; essential for a midmitotic transition; leucine-rich repeat protein that positively modulates protein phosphatase-1; genbank m57495
sdsB protein, Pseudomonas sp.: amino acid sequence given in first source; a 33.6 kda protein isolated from pseudomonas and involved in sodium dodecyl sulfate (sds) degradation; a positive activator protein similar to the lysr family of helix-turn-helix dna-binding activator proteins
sea protein, Gallus gallus: a tyrosine kinase receptor; encoded by proto-oncogene c-sea; related to the met/hepatocyte growth factor/scatter factor receptor; amino acid sequence given in first source; genbank l12024 (g gallus)
sea star factor: 39,000 da protein form the coelomocytes of the echinoderm asteria forbesi; has biological effects in humans which resemble those of lymphokines
sea1 protein, Enterococcus faecalis: amino acid sequence given in first source; homologous to surface exclusion protein sec10 encoded by sex pheromone plasmid pcf10
sebastianine A: biologically active pyridoacridine alkaloid from the brazilian ascidian cystodytes dellechiajei
sebastianine B: biologically active pyridoacridine alkaloid from the brazilian ascidian cystodytes dellechiajei
sec10 protein, Drosophila: has no detectable role in most forms of polarized trafficking/exocytosis, including neurotransmission, but rather is essential for endocrine secretion
sec8 protein, S pombe: a hydrophilic protein essential for exocytosis; forms complex with sec6; may be involved in transport of basal-lateral proteins via vesicles to regions of cell-cell contact
secD protein, Bacteria: protein-export membrane protein; component of preprotein translocase; amino acid sequence has been determined
secErbB4-26-549: antagonizes ligand-induced erbb4 tyrosine phosphorylation
secF protein, Bacteria: protein-export membrane protein; component of preprotein translocase; amino acid sequence has been determined
secalonic acid: consists of 4 acids (a,c,d,e) differing only in their stereochemistry; rn given is for parent cpd
secamine: from amsonia elliptica; rn & nl from 9th ci; cpd not in chemline 8/83
secapin-2: from africanized honeybee (apis mellifera) venom
secaubryenol: 3,4-seco-cycloartane from an exudate collected on the aerial parts of gardenia aubryi
secaubryolide: 3,4-seco-cycloartane from an exudate collected on the aerial parts of gardenia aubryi
secaubrytriol: 3,4-seco-cycloartane from an exudate collected on the aerial parts of gardenia aubryi
secbutabarbital: butabarbital (a synonym for secbutabarbital) should be distinguished from butobarbital
secernin 1 protein, mouse: involved in regulating exocytosis in mast cells; genbank ak012765
sechiumin protein, Sechium edule: a 27 kda ribosome-inactivating protein from edible gourd, sechium edule; amino acid
seclazone: was mh 1975-91 (see under oxazines 1975-90)
seco(D-Asp(3))microcystin-RR: from a planktothrix rubescens toxic bloom collected in lake bled, slovenia
seco-A-oleanane-3,4-lactone: suppresses hepatitis b virus antigen (hbeag) secretion
seco-bipinnatin J: isolated from the west indian gorgonian octocoral pseudopterogorgia bipinnata
seco-briarellinone: from the panamanian octocoral briareum asbestinum
seco-milbemycin A: isolated from streptomyces bingchenggensis
seco-milbemycin B: isolated from streptomyces bingchenggensis
secobotrytriendiol: a phytotoxic metabolite from botrytis cinerea
secoemestrin D: from emericella sp. ast0036, a fungal endophyte of astragalus lentiginosus1
secoferruginol: activates dendritic cells; isolated from cryptomeria japonica
secohalichondramide: oxazole-containing metabolite from the sponge chondrosia corticata
secoheliosphane A: a diterpenoid isolated from whole plants of euphorbia helioscopia
secoheliosphane B: a diterpenoid isolated from whole plants of euphorbia helioscopia
secoheliospholane A: a diterpenoid isolated from whole plants of euphorbia helioscopia
secoisolariciresinol: rn given refers to ((r-(r*,r*))-isomer); rn for cpd without isomeric designation not available 8/89; precursor of lignans found in human urine
secoisolariciresinol dehydrogenase: catalyzes the conversion of secoisolariciresinol to matairesinol; genbank af352734 and af352735
secoisolariciresinol diglucoside: major precursor of mammalian lignans; ; rn given refers to b-d-gluco isomer
secoisolariciresinol-O-rhamnopyranoside: from rubus amabilis
secologanic acid: a major secoiridoid in the flower buds of lonicera japonica
secologanin synthase: catalyzes oxidative cleavage of the cyclopentane ring of loganin to form secologanin
secomilbemycin C: from streptomyces bingchenggensis
secomilbemycin D: from streptomyces bingchenggensis
secondary alkyksulfohydrolases: from detergent-degrading pseudomonas
secondary amine monooxygenase: catalyzes nadh or nadph dependent oxidative n-dealkylation of short chain aliphatic secondary amines with a methyl or ethyl group
secorhodomollolide A: from the flower buds of rhododendron molle
secramine A: inhibits vsvg transport from the golgi to the plasma membrane; also inhibits cdc42-dependent cell functions
secreted antigen 1, Babesia gibsoni: 59kda secreted antigen used in serodiagnosis; amino acid
secreted autotransporter toxin, E coli: produced by a diffusely adhering escherichia coli strain that causes intestinal damage in animal model assays
secreted glycoprotein, Ebola virus: secreted form of ebola virus glycoprotein; secreted and transmembrane forms arise from rna editing; amino acid
secreted ookinete adhesive protein, Plasmodium: an extracellular malaria protein expressed in ookinetes and young oocysts; soap gene is highly conserved amongst plasmodium species and appears to be unique to this genus; genbank ay046918
secreted phosphoprotein 24: a bone phosphoprotein; related in sequence to the cystatin family of thiol protease inhibitors; multiply phosphorylated at ser residues in ser-x-glu/ser(p) sequences; mw 24 kda; amino acid sequence given in first source; genbank u08018
secretin releasing peptide: exists in dog pancreatic juice it is trypsin-sensitive and heat-resistant
secretogranin 2, rat: gonadotrope polypeptide (gp 87) released from rat pituitary cells under luteinizing hormone-releasing hormone stimulation is a secretogranin ii form
secretogranin III: a member of the granin protein family, is expressed specifically in neuronal and endocrine cells
secretogranin IV: a member of the granin protein family, components of secretory granules in most neuroendocrine cells
secretolytin: an endogenous c-terminal fragment of chromogranin b; amino acid sequence given in first source; genbank p23389
secretoneurin: a 33-amino acid sequence generated upon proteolytic processing of secretogranin ii
secretory carrier membrane protein 2, mouse: an nkcc2 binding partner; genbank af295402
secretory component receptor, human: 15 kda protein expressed from human eosinophils; rn refers to immunoglobulin receptor (human polymeric protein secretory component)
secretory granule proteoglycan: nucleotide sequence given in first source; mw 17,600 and contains an 18 amino acid glycosaminoglycan region that consists primarily of alternating serine and glycine
secu'amamine B: from the wood of securinega suffruticosa var. amamiensis
secu'amamine C: from the wood of securinega suffruticosa var. amamiensis
secu'amamine D: from the wood of securinega suffruticosa var. amamiensis
secukinumab: a fully human antibody to interleukin-17a for treatment of psoriasis, rheumatoid arthritis, and uveitis
securidacaxanthone A: a heptaoxygenated xanthone from securidaca longepedunculata
securinine: a quinolizine pseudoalkaloid (not from amino acid) from securinega suffurutiosa or securinini nitras
securixanside A: xanthone glycoside from securidaca inappendiculata
securixanside B: xanthone glycoside from securidaca inappendiculata
securixanside C: xanthone glycoside from securidaca inappendiculata
sedi-stain: simple stain for differentiating semen constituents not available commercially; said to be similar in content to sternheimer-malbin stain
sedlin protein, mouse: gene sedlin mutations cause spondyloepiphyseal dysplasia tarda; refseq nm_025432
sedoheptulose-7-phosphate isomerase, Neisseria gonorrhoeae: catalyzes the first step of nucleotide-activated-glycero-manno-heptose biosynthesis
sedridine: rn given refers to (s-(r*,r*))-isomer; allosedridine is the (r*,s*)-isomer
seeligeriolysin O, Listeria seeligeri: a protein toxin that stimulates macrophage cytokine production via toll-like receptors in a profile different from that induced by other bacterial ligands
sefA protein, Salmonella enteritidis: a 14 kda fimbrial gene product; mature form of 16-kda protein ap16; amino acid sequence given in first source
sefB protein, Salmonella: a 28 kda fimbrial gene product; amino acid sequence given in first source
sefC protein, Salmonella enteritidis: a 90 kda fimbrial gene product; amino acid sequence given in first source
seganserin: mw=471.55+72.92; mf=c29-h27-f2-n3-o. 2hcl
segetalin C: a natural phenylalanine-rich cycloheptapeptide; antifungal and cytotoxic agent
segetoside B: inhibits luteal cell activity; isolated from the seeds of vaccaria segetalis
seglitide: more potent than somatostatin for inhibition of insulin, glucagon & growth hormone release; used experimentally in treatment of alzheimer's disease; somatostatin receptor antagonist
seimatopolide A: isolated from an extract of seimatosporium discosioides; ppar-gamma agonist and a possible therapeutic candidate for treatment of diabetes
seimatopolide B: isolated from an extract of seimatosporium discosioides; ppar-gamma agonist
seimatoporic acid A: isolated from an endophytic fungus, seimatosporium sp.
seimatoporic acid B: isolated from an endophytic fungus, seimatosporium sp.
seimatorone: from the endophytic fungi, microsphaeropsis sp. and seimatosporium sp. with moderate antibacterial, antialgal, and antifungal activities
seimisochromene A: from the endophytic fungus, seimatosporium sp.
seimisochromene B: from the endophytic fungus, seimatosporium sp.
seipin protein, S cerevisiae: a transmembrane protein that resides in the endoplasmic reticulum and concentrates at junctions between the er and cytosolic lipid droplets
seirogan: folk remedy in japan consisting of a mixture of wood creosote and plant extracts; used for stomach aches; may cause stomach neoplasms
sekgranaticin: a sek34b-granaticin hybrid polyketide isolated from streptomyces sp. 166
sel protein, Drosophila: an endoplasmic reticulum-resident protein of the saposin-like protein family; refseq nm_136703
selaginellin G: has antifungal activity; isolated from selaginella pulvinata
selagintriflavonoid A: bace1 inhibitor from the fern selaginella doederleinii
selectin 1, Biomphalaria glabrata: a 36 kda protein expressed by biomphalaria glabrata embryonic cells with a domain homologous to the lectin domain of mammalian selectins; amino acid
selective progesterone receptor modulator EC313: steroidal progestin with differential binding towards steroids receptors such as pr and glucocorticoids
selectride: l-, n-, and k-selectrides are lithium, sodium, and potassium salts, respectively, of selectride
selenate reductase: terminal electron acceptor for anaerobic respiration in thauera selenatis; reduces selenate to selenite
selenazofurin 5'-triphosphate: rn given from toxline; rn not in chemline 7/86
selenium transferase: converts phosphoseryl-trna to selenocysteinyl-trna; product of sela gene; converts seryl-trna(sec)(uca) to selenocysteyl-trna(sec)(uca) in pyridoxal-phosphate dependent reaction
selenobiotin: replaces biotin as a growth factor for several microorganisms; incorporated into carboxymethylases without loss of enzyme activity; with e. coli, the selenoacetyl-coa carboxylase is as active as the normal enzyme
selenocystaldimine: cyclicized aminoaldehyde from selenocystamine structure
selenocysteine insertion sequence binding protein, mammalian: secis - selenocysteine insertion sequence; has been sequenced but no links available
selenocysteine lyase: decomposes l-selenocysteine into l-alanine & h2se
selenocysteine methyltransferase: transfers methyl group from s-adenosylmethionine to the selenium atom of selenocysteine to form se-methyl-selenocysteine; plays a crucial role in conferring selenium tolerance; from astragalus bisculatus
selenocysteinyl-tRNA: selenocysteinylated trna, which may be either serine-accepting trna(ser) or selenocysteine-accepting trna(sec); do not confuse with trna, selenocysteine- which is the trna which has not yet been selenocysteinylated
selenodeiodinase type 1, mouse: targeted disruption of the type 1 selenodeiodinase gene (dio1) results in marked changes in thyroid hormone economy; refseq mrna sequence nm_007860; source sequence ak002549,u49861; product np_031886
selenomethionine glycinamide ribonucleotide synthetase: selenomethionine incorporated into phosphoribosyl-glycinamide synthetase (ec 6.3.4.13); amino acid sequence known
selenomethionyl choriogonadotropin: used to solve the crystallization and phase problems of hcg
selenonium choline: ; more toxic than choline; exerts protective effect against acetylcholinesterase inhibition
selenophosphate synthetase: involved in selenium metabolism; gamma-phosphate of atp is transferred to hse resulting in formation of monoselenophosphate; amino acid
selenoprotein A: part of the clostridial glycine reductase complex; amino acid sequence given in first source
selenoprotein B, Bacteria: part of glycine reductase complex; mw 47 kda; genbank u24268 ( clostridium litorale)
selenoprotein H, human: involved in redox homeostasis by affecting glutathione synthesis; also affects phase ii detoxification; genbank af085883
selenosubtilisin: catalytically essential serine of subtilisin replaced by selenocysteine; possesses peroxidase activity
selenotrisulfide: inhibits initiation by rna polymerase ii but not elongation
selesconol: fungal polyketide isolated from culture of daldinia eschscholzii ifb-tl01; induces differentiation of rat bone marrow mesenchymal stem cells into neural cells
seletalisib: a phosphatidylinositol 3-kinase delta inhibitor
self incompatibility associated protein S3, Solanum chacoense: amino acid sequence given in first source; pistil-specific protein of 30 kda
self-assembled cyclic trisporphyrin trimer: a macroring that consists of three triporphyrin molecules, each porphyrin ring of which is coordinated with zinc, that coordinate each other via bonds between zinc and one of the 1-methylimidazol-2-yl groups
self-incompatibility associated protein S2, Solanum chacoense: amino acid sequence given in first source; pistil-specific protein of 30 kda
self-incompatibility glycoprotein, Nicotiana: si gene has 3 alleles, s2, s3 & s6 with overall 56% homology; the self-incompatibility (si) system is controlled by a single s-gene; from nicotiana alata; amino acid sequence given in first source; rn refers to s2
self-incompatibility locus specific glycoprotein, Brassica: from brassica plants; amino acid
self-incompatibility ribonuclease S3: a style glycoprotein from wild tomato, lycopersicon peruvianum; amino acid
self-incompatibility ribonuclease S4: amino acid ; genbank ab009385
self-induced endogenous elicitor: an acidic polysaccharide; mw 9,200 da; composed of a 2:3:4:7 mixture of galactose, rhamnose, arabinose and galacturonic acid
selfotel: a n-methyl-d-aspartate (nmda) antagonist; used to treat stroke-induced impairment
selicrelumab: a fully human and selective cd40 agonist monoclonal antibody, was well tolerated and biologically active, and was associated with antitumor activity
selina-1,3,7(11)-trien-8-one: a component of the essential oil of eugenia uniflora
selina-4 (14),7(11)-dien-8-one: from atractylodes macrocephala rhizoma (amr), a traditional chinese medicine
selinidin: from angelica keiskei, ashitaba in japan; suppresses ige-mediated mast cell activation by inhibiting multiple steps of fc epsilonri signaling
selligueain A: ; a proanthocyanidin isolated from the rhizomes of selliguea feei
sellowin A: norditerpene lactone isolated from podocarpus hallii with potential activity against development in housefly
selurampanel: anticonvulsant that antagonizes both ampa and kainate receptors
sem-4 protein, C elegans: controls neuronal & mesodermal cell development in caenorhabditis elegans; rn refers to long isoform; amino acid ; genbank u60112-3
sema3ab protein, zebrafish: inhibits growing motor axons; may play a role by influencing the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite; amino acid
semaphorin 3G, mouse: mainly expressed in the lung and kidney, and a little in the brain; binds neuropilin-2, but not neuropilin-1, and induces the repulsion of sympathetic axons; refseq mrna sequence xm_138955 xp_138955
semaphorin 4E, zebrafish: a transmembrane sema4e that guides branchiomotor axons to their targets in zebrafish; both necessary and sufficient for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and sufficient for guidance of gill motor axons; has been sequenced
semaphorin 5A, rat: a bifunctional axon guidance cue; has been sequenced
semaphorin 5A, zebrafish: a bifunctional axon guidance cue; genbank fj209030
semaphorin 6D, zebrafish: genbank ab212073 (sema6d-l) and ab212074 (sems6d-s)
semaphorin A(V): nerve growth cone guidance signal; amino acid ; genbank u28369
semaphorin IV: nerve growth cone guidance signal; amino acid ; genbank u32172 (clone h1.47) and u32171 (clone h2.6)
semaphorin K1: gpi-anchored protein related to viral semaphorins; amino acid ; genbank af071542; nm_003612
semaphorin Z7: isolated from zebrafish; amino acid ; genbank af073289
semaphorin Z8: isolated from zebrafish; amino acid ; genbank af073290
semapimod: macrophage-deactivating agent used to treat experimental autoimmune encephalomyelitis in mice; prevents postoperative ileus in mice independently of anti-inflammatory vagus nerve signaling
semecarpifoline: from the root bark of melicope semecarpifolia (rutaceae)
semenoclotin: a clot-forming protein of mouse semen; similar in sequence but smaller than svs ii, the major clot-forming protein of rat semen; mw 38.4 kda; isoelectric point 10.68; amino acid sequence given in first source
semicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouse: a bifunctional protein that both catalyzes conversion of primary amines to aldehyde and promotes interaction between lymphocytes and endothelial cells; genbank af054831
semicochliodinol A: inhibits hiv-1 protease and egf-r protein-tyrosine kinase; isolated from chrysosporium merdarium
semicochliodinol B: inhibits hiv-1 protease and egf-r protein-tyrosine kinase; isolated from chrysosporium merdarium
seminal plasma inhibin (85-94), Tyr(85), Cys(Acm)(87)-: suppresses follicle stimulating hormone release in rats
seminal vesicle autoantigen: autoantigen secreted from mouse seminal-vesicles; androgen-stimulated secretory protein; core protein consists of 131 amino acid; mw 19 kd
seminal vesicle secretory protein 109, Bos taurus: a major acidic protein of 109-amino acids found in bovine seminal plasma; mw of 13 kda; a polypeptide with two structurally similar domains of 38 and 41 amino acids (bsp-a1 and bsp-a2), each containing two disulfide bonds; these proteins potentiate sperm capacitation
seminal vesicle secretory protein 109, porcine: from porcine seminal plasma; contains 109 amino acid residues & has a glycosylation site at the asparagine residue at position 47; amino acid
seminal vesicle secretory protein II, porcine: from porcine seminal plasma; amino acid
seminal vesicle-specific antigen: svsa is the predominant protein in seminal plasma; contributes to the rapid clotting of ejaculate; semg1 is a 15 kda secretory protein inhibitor of sperm motility; semg2 is mw 62.9 kda and participates in the formation of gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa; refseq nm_003007 (semg1); nm_003008 (semg2)
seminalplasmin, Lys(13)-: lysine replaces glutamine of seminalplasmin; has antibacterial properties but does not cause hemolysis
seminolipid: main glycolipid in testis and spermatozoa of various mammals
senA protein, E coli: an enterotoxin in enteroinvasive escherichia coli and shigella flexneri; mw 63 kda; amino acid sequence given in first source; genbank z54194
senS protein, Bacillus subtilis: from bacillus subtilis; the gene stimulates expression of several extracellular protein genes; codes for a highly charged basic protein containing 65 amino acid residues; amino acid sequence given in first source
senaparib: a novel, potent poly-(adp-ribose) polymerase 1/2 inhibitor; has demonstrated promising clinical antitumour activity
senecionine N-oxygenase: an nadph-dependent flavin monooxygenase that catalyzes the conversion of senecionine to senecionine n-oxide
senecrassidiol: from aerial parts of bethencourtia hermosae, transformed by agrobacterium rhizogenes
senegalensin: from stem bark of cameroonian medicinal plant erythrina senegalensis
senescence-associated receptor-like kinase, Phaseolus vulgaris: isolated from the bean phaseolus vulgaris; genbank af285172
senescent cell differentiation antigen: terminal differentiation antigen; appears on surface of senescent & damaged cells; initiates immunologic binding of physiologic igg autoantibodies & removal of the cells by macrophages; derived from band 3 protein
senesionine: from miracle tea (packera candidissima and p. bellidifolia)
senfolomycin A: ; isolated from streptomyces paulus; senfolomycin b is also available
senfolomycin B: ; isolated from streptomyces paulus; may be dihydrosenfolomycin a
senkirkine: macrocyclic secopyrrolizidine alkaloid from senecio; ; rn given refers to senkirkine
senkyunolide H: from ligusticum chuanxiong; structure nin first source
senkyunolide I: has antioxidant and anti-migraine activities; isolated from ligusticum chuanxiong
sennomotokounou: a chinese dietary supplement for weight loss; contains fenfluramine, n-nitroso-fenfluramine, and dried thyroid tissue powder
sennoside C: rn given refers to sennoside c; see also record for sennoside a&b
sens protein, Drosophila: necessary and sufficient for sensory organ development in drosophila; amino acid ; refseq nm_080079
sensor rhodopsin csR-3, Haloarcula vallismortis: isolated from haloarcula vallismortis; amino acid
sensorin A protein, Aplysia: expressed in sensory neurons in mollusk aplysia; has been sequenced
sensory neuron membrane protein 1: from olfactory neurons of silk moth, antheraea polyphemus; mw 67 kda; amino acid sequence given in first source; genbank u95026
sensory neuron membrane protein 2, Antheraea polyphemus: member of invertebrate cd36-like proteins from silk moth antheraea polyphemus; genbank af323589
sensory neuron-specific receptor 1, rat: refseq nm_172158.2
sensory rhodopsin II protein, archaeal: from halobacterium halobium; sopii is the blue light receptor from halobacterium salinarium
sentulic acid: has antineoplastic activity; isolated from sandoricum koetjape
seonghyangjeongkisan: a traditional korean medicine used to treat cerebral infarction
seongomycin: a kinamycin-related metabolite isolated from streptomyces murayamaensis mutants generated via chemical mutagenesis
sep1 protein, S pombe: a forkhead homologue isolated from schizosaccharomyces pombe; amino acid ; do not confuse with sep1 protein
sepA protein, Serratia entomophila: isolated from serratia entomophila; amino acid ; ; do not confuse with sepa protein
sephadex, 2-hydroxypropyl ether: rn given refers to 2-hydroxypropyl ether sephadex g 50
sepharose-4B-(dodecanate)-5'-luciferinylglucuronate: chemoluminescent probe; partial
sepiapterin synthase: dihydroneopterin is converted to sepiapterin in the presence of one or more enzymes
seprase, human: a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer
septemlobin D: has antineoplastic activity; isolated from solanum septemlobum
septilin: combination of herbominerals, primarily guggul and phyllanthus emblica
septocylindrin A: peptaibol produced by the terrestrial fungus septocylindrium sp.
septocylindrin B: peptaibol produced by the terrestrial fungus septocylindrium sp.
seq protein, Drosophila: a tramtrack-related pan-neural regulator for both axon and dendrite morphogenesis; isolated from drosophila; genbank af421370
sequosempervirin A: isolated from dried and powdered branches and leaves of sequoia sempervirens
serantrypinone: from penicillium thymicola; a tricyclic pyrazinoquinazolinedione base bridged by a 3-methyleneoxindole substructure
seratrodast: has thromboxane a2 & prostaglandin h2 receptor antagonistic action
serdexmethylphenidate and dexmethylphenidate: fda approved for the treatment of attention deficit hyperactivity
sergeolide: quassinoid from simaroubaceae picrolemma pseudocoffea
sergliflozin: a hypoglycemic agent that inhibits sglt2 sodium-glucose transporter
serglycin: peptide core of a secretory granule protoglycan; has been sequenced
seribantumab: an anti-erbb3 antibody in clinical trials (2014) for treating cancer
serin-rich spermatogenic protein 1, rat: a rat gene differentially expressed during spermatogenesis and coding for a serine stretch-containing protein; amino acid
serine containing aminolipid: analog of ornithine containing aminolipid; rarely present in bacteria; protects mice form lethal endotoxemia
serine dipeptide lipid 654: isolated from porphyromonas gingivalis
serine protease PB92: a subtilase from bacillus alcalophilus; 269 amino acid residues; amino acid sequence has been determined
serine protease inhibitor Kazal-type-like protein, mouse: found to be primarily expressed in seminal vesicles
serine proteinase P-57: from erythrocyte membranes; mw 57kda; cleaves alpha- & beta-chains of human complement 3; inhibited by phenylmethylsulfonyl fluoride; see also factor i, c 3b inactivator
serine proteinase PC: isolated from camchatka crab; mw 29 kda; splits the peptide bonds formed by the carboxyl group of hyrophobic amino acids, arginine and lysine, in peptides and proteins; hydrolyzes fibrin & collagen; n-terminal amino acid sequence given in first source
serine racemase: refseq nm_013761 (mouse); nm_021947 (human); nm_198757 (rat)
serine repeat antigen, Plasmodium: an exported blood stage antigen; mw 111 kda; amino acid sequence in first & second source
serine-7-amino-4-methylcoumarin carbamate: fluorogenic tryptophanase substrate
serine-borate complex: affects leukotriene binding; consists of serine & sodium borate
serine-glyoxylate aminotransferase: pea enzyme; also uses asparagine as amino donor with either pyruvate or glyoxylate as acceptor
serine-pyruvate aminotransferase: do not confuse with alanine-glyoxylate aminotransferase (ec 2.6.1.44), even though they may be products of the same gene; index whichever is discussed or both
serine-rich glycoprotein A, Streptococcus sanguis: mediates adhesion to platelets via gpib; has been sequenced
serine-rich protein, Entamoeba histolytica: plays a role in amebic adhesions to mammalian cells; amino acid has been determined
serjanic acid 3-O-(beta-D-glucopyranosyl-(1''-3')-alpha-L-arabinopyranosyl)-28-O-beta-D-glucopyranoside: oleanane saponin from chenopodium quinoa
serogroup C meningococcal conjugate vaccine: safe & immunogenic for infants 2-4 months
serosophil: absorbable suture made from serous membrane of pigs' small intestine
serotonin 2Lym receptor, Lymnaea stagnalis: from mollusc lymnaea stagnalis; genbank u50080
serotonin 5 receptor: has remarkable heterogeneity within the 5ht1d receptor family; 5a & 5b are two subtypes; amino acid
serotonin 6 receptor: amino acid ; genbank l41147 (human) and l41146 (rat)
serotonin adipinate: prevents postoperative intestinal paresis; rn given refers to (1:1) mixture
serotonin receptor-like planarian receptor 1, Dugesia japonica: 5htlpla - serotonin receptor-like planarian receptor; genbank ab004541
serotonin-O-carboxymethyl-Gly-Tyr: ; ligand for serotonin receptor subtypes
serotonin-binding protein: see also serotonectin which is a serotonin-binding protein from platelets; differs from neuronal serotonin-binding protein
serotonin-binding protein kinase: an aspect of protein kinases ec 2.7.1.37
serotonin-rat serum albumin conjugate: used to induce production of antibodies against serotonin
serp protein, Drosophila: a tracheal matrix protein with chitin n-deacetylase activity; refseq nm_168811
serpentine (alkaloid): do not confuse with mineral serpentine; rn given refers to (19alpha)-isomer
serpin A1 (A1-C26), human: a c-terminal fragment that inhibts hiv-long terminal repeat-driven transcription
serpin-enzyme complex receptor: high-affinity cell surface receptor; capable of modulating the production of at least one of the serpins, alpha1-antitrypsin; may be involved in the clearance of certain serpin-enzyme complexes
serpinin protein, mouse: a c-terminal peptide that upregulates protease nexin-1 expression and granule biogenesis
serralongamine B: inhibits foam cell formation; isolated from lycopodium serratum
serralongamine D: inhibits foam cell formation; isolated from lycopodium serratum
serralysin: zinc metalloproteinases with broad similar specificity for cleavage of the oxidized insulin b chain
serrat-14-ene-3,21-diol: from the stem bark of erythrina eriotriocha
serratanine: serratanine is mixture of serratanine a & serratanine b; serratanine a same as lucidine b; serratanine b same as oxolucidine b; structures of serratanine a & serratanine b in first source
serrate2 protein, mouse: involved in mouse limb-development in syndactylism (sm) mutation; also from chicken; ligand for notch protein; amino acid
serratiopeptidase: proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections
serrawettin W2: extracellular cyclic lipopeptide which promotes flagellum-dependent & -independent spreading growth of serratia marcescens; amino acid sequence given in first source
serrawettin W3: from serratia marcescens; cyclodepsipeptide which is a surface active exolipid
serrulatic acid: bactericidal and cyclooxygenase inhibitory diterpene from eremophila sturtii
serrumab: neutralizes toxins in tityus serrulatus scorpion venom
sertraline carbamoyl-O-glucuronide: metabolite of sertraline
serum albumin-EDTA-gadolinium complex: relaxation agent for the measurement of water exchange rates in erythrocyte suspensions
serum albumin-EDTA-manganese complex: relaxation agent for the measurement of water exchange rates in erythrocyte suspensions
serum cancer-suppressive peptide, mouse: protein from mouse ascites; mw apprx 3,000
serum immunosuppressive factor, human: found in serum of cancer patients; also found in patients with infectious diseases & chronic renal failure; mw 52,000
serum resistance associated protein, Trypanosoma brucei: a member of the variable surface glycoprotein family; isolated from trypanosoma brucei rhodesiense; genbank af097331
serum sodium transport inhibitor: substance in blood of patients with essential hypertension which influences active transport of sodium; peptide from cultured leukemic promyelocytes
serum thyroid hormone reducing factor: biologically active factor that induces the deviation of thyroid hormone metabolism; has been partially purified from the soluble cytosol fraction of walker 256 carcinoma cells; heat-labile protein and specific to the tumor tissue
serum tumorlytic factor: a tumor necrosis factor homolog induced in serum of mice injected with t-cell mitogen from corynebacterium kutscheri; partial amino acid sequence given in first source
serum-glucocorticoid regulated kinase: highly regulated at the transcriptional level by glucocorticoid hormones & serum; suggests a novel interplay between glucocorticoid receptor signalling & a protein kinase of the second messenger family; may play a role in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion; amino acid sequence given in first source; refseq nm_011361 (mouse), nm_005627 (human), nm_019232 (rat)
serum-inducible kinase: do not confuse with snake protein, drosophila; refseq nm_152804 (mouse)
seryl-HYPE(transpropyl)-octahydroindole-2-carbonyl-arginine: bradykinin receptor antagonist; amino acid sequence given in first source
seryl-alanyl-leucy-leucyl-arginyl-seryl-isoleucyl-prolyl-alanine: a neuroprotective agents
seryl-arginyl-leucyl-leucyl-argininamide: a proteinase-activated receptor agonist
seryl-aspartyl lysine acetylated: tripeptide which is a strong inhibitor of liver cell proliferation
seryl-glutaminyl-alanyl-phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide: a human neuropeptide ff-related peptide
seryl-glutaminyl-asparaginyl-tyrosyl-prolyl-isoleucyl-valyl-glutamine: an hiv-1 protease peptide substrate
seryl-histidine: both amino acids function together as key catalytic amino acids in the active sites of diverse enzymes as the serine- and thiol-proteases, lipases, and esterases
seryl-isoleucyl-lysyl-valyl-alanyl-valinamide: laminin-derived sikvav-containing peptide can promote angiogenesis & tumor growth
seryl-leucyl-isoleucyl--glycyl-lysyl-valine: derived from amino-terminus of proteinase-activated receptor 2 (par-2)
seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide: a proteinase-activated receptor-2-activating peptide; sl-nh2 is not ser-leu-nh2 here
seryl-leucyl-isoleucyl-glycyl-lysyl-valinamide: a proteinase-activated receptor agonist
seryl-leucyl-seryl-arginyl-tyrosyl-alanyl-lysyl-leucyl-alanyl-asparaginyl-arginyl-leucyl-alanine: a 13 aa residue segment in seminalplasmin; has only antibacterial activity without hemolytic properties
seryl-lysyl-prolyl-tyrosyl-methionyl-arginyl-phenylalaninamide: fmrfamide peptide from extracts of the cns of the fresh water snail lymnaea stagnalis
seryl-methionyl-seryl-alanyl-arginyl-glutaminyl-leucine: has both nootropic and anti-inflammatory activity
seryl-phenylalanyl-lysyl-leucyl-arginyl-tyrosinamide: has angiogenic activity
seryl-phenylalanyl-octahydroindole-2-carbonyl-arginine: bradykinin receptor antagonist; amino acid sequence given in first source
seryl-phenylalanyl-phenylalanyl--leucyl-arginyl-asparaginyl-prolyl-seryl-glutamic acid: a par1 receptor agonist
seryl-phenylalanyl-phenylalanyl-leucyl-arginyl-asparaginyl-proline: a synthetic thrombin receptor peptide
seryl-prolyl-arginyl-prolyl-arginyl-histidyl-threonyl-leucyl-arginyl-leucyl-seryl-leucine: a synthetic transferrin receptor 1 ligand
seryl-prolyl-lysyl-lysine: nucleic acid-binding unit of protein found in histone
seryl-seryl-leucyl-seryl-lysyl-leucine: has immunomodulatory activity; isolated from a mexican frog
seryl-seryl-seryl-arginine: derived from insulin-like peptide factor-1
seryl-tRNA(GCU): mammalian mitochondrial trna that lacks the whole d arm; also found in squid
seryl-tRNA-ATP phosphotransferase: produces phosphoseryl trna; plays suppressor role in in vitro globin synthesis
seryl-tetrahydroisoquinolinecarbonyl-octahydroindole-2-carbonyl-arginine: bradykinin receptor antagonist; amino acid sequence given in first source
seryl-tryptophyl-lysyl-leucyl-prolyl-prolyl-serine: contains the klp motif that may serve as targeting ligand for peritoneal tumors of gastric cancer
seryl-tryptophyl-threonyl-leucyl-tyrosyl-threonyl-prolyl-seryl-glycyl-glutaminyl-seryl-lysine: synthetic peptide that binds n-cadherin
sesB protein, Drosophila: encoded by temperature-sensitive allele, involved in acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation; refseq nm_078554
sesamex: minor descriptor (72-85); on-line & index medicus search dioxoles (72-85); rn given refers to parent cpd
sesamin: constituent of sesame oil; rn given refers to (1s-(1alpha,3aalpha,4alpha,6aalpha)-isomer); episesamin is an epimer of sesamin
sesaminol: ; rn given from cas index guide 1990; rn given refers to the (1s-(alpha,3aalpha,4alpha,6aalpha))-isomer; rn for cpd without isomeric designation not available 11/90
sesaminol triglucoside: dietary glucoside from sesame that inhibits azoxymethane-induced premalignant lesions of rat colon
sesaminone: a tetrahydrofuran lignan; produced by streptomyces
sesamolin: constituent of sesame oil; rn given refers to the (1s-(1alpha,3aalpha,4alpha,6aalpha)-isomer); inhibits proliferation of human lymphocytic leukemia cells in culture
sesamolinol diglucoside: lignan glucoside from defatted sesame seed flour
sesamoside: an iridoid glucoside; from phlomis mongolica turz; rn given refers to (1ar-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-isomer
sesbagrandiflorain A: arylbenzofuran isolated from stem bark of sesbania grandiflora
sesbagrandiflorain B: arylbenzofuran isolated from stem bark of sesbania grandiflora
sesbanine: spirocyclic alkaloid from sesbania drummondii devoid of antitumor activity; rn given refers to (1r-trans)-isomer
seselinone: a cytotoxic tetrahydrofuranoid lignan from the aerial parts of seseli annuum
sespendole: an inhibitor of lipid droplet synthesis in macrophages, produced by pseudobotrytis terrestris
sesquibastadin: a trimeric hemibastadin derivative from the marine sponge ianthella basta
sesquiterpenoid dehydrogenase: converts elema-1,3,11(13)-trien-12-ol and elema-1,3,11(13)-trien-12-al to elema-1,3,11(13)-trien-12-oic acid; requires nadp+; involved in sesquiterpene lactone biosynthesis
sessiline: a new nitrogenous compound from the fruits of acanthopanax sessiliflorus
sesteralterin: from the marine-alga-epiphytic fungus alternaria alternata k21-1
sesterstatin 1: sesterterpene isolated from the marine sponge hyrtios erecta
sesterstatin 2: sesterterpene isolated from the marine sponge hyrtios erecta
sesterstatin 3: sesterterpene isolated from the marine sponge hyrtios erecta
sesterstatin 4: sesterterpene isolated from the marine sponge hyrtios erecta
sesterstatin 5: sesterterpene isolated from the marine sponge hyrtios erecta
sesterstatin 6: antineoplastic agent from the indian ocean sponge hyrtios erecta
sesterstatin 7: antimycobacterial scalarane-based sesterterpene from the red sea sponge hyrtios erecta
setA protein, E coli: a sugar efflux pump isolated from e. coli; has been sequenced
setB protein, E coli: a sugar efflux pump isolated from e. coli; has been sequenced
setC protein, E coli: a sugar efflux pump isolated from e. coli; has been sequenced
setanaxib: nox4/nox1 inhibitor; a pyrazolopyridine dione derivative
setarud: prepared from rosa canina, tanacetum vulgare and urtica dioica; has immunomodulatory, anti-inflammatory and antioxidant properties
setomimycin: isolated from culture broth of streptomyces pseudovenezuelae
seungma-galgeun-tang: used to treat skin disorders; consists of cimicifuga heracleifolia kom, pueraria lobata ohwi, paeonia lactiflora pallas, and glycyrrhiza uralensis
sev protein, Drosophila: 2554 amino acid residues given in first source; tyrosine kinase domain plays an essential role in the function of the sev protein in the determination of the r7 photoreceptor cell
sevadicin: antibacterial non-ribosomal peptide secondary metabolite produced by the honey bee pathogenic bacterium paenibacillus larvae
seven in absentia protein, Schistosoma mansoni: stimulates ubiquitination of smrxr1 and smrxr2; genbank ay227022
seven-transmembrane G-protein-coupled receptor: a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells & induced in hypoxia; has been sequenced
severin kinase, Dictyostelium: 62-kda member of the germinal center kinase subfamily of the ste20 protein kinase family; isolated from dictyostelium; genbank af059534
severin protein, Dictyostelium: 40,000 dalton protein from dictyostelium that dissociates actin filaments in ca++ dependent manner
sevirumab: an anti-cytomegalovirus antibody directed against envelope glycoprotein h
sewarine: rn is from 9th ci; cpd not in chemline 9/17/82
sex pheromone cAM373, Staphylococcus aureus: differs from strep f cam373 only in the c-terminal residue
sex pheromone cAM373, Streptococcus faecalis: isolated from streptococcus faecalis; heptapeptide of mw 733
sex pheromone inhibitor iAD1: enterococcus faecalis plasmid pad1 encodes a mating response to peptide cad1 (see record for cad1 bacterial sex hormone); shuts down production of cad1 and encodes the secretion of peptide iad1 which acts as a competitive inhibitor of cad1
sex pheromone inhibitor iAM373: a heptapeptide; from enterococcus faecalis
sex pheromone inhibitor iPD1: excreted by streptococcus faecalis donor strains harboring bacteriocin plasmid ppd1; inhibits sex pheromone cpd1
sex-influenced esterase: sex hormone-dependent enzyme; liver enzyme may be a precursor of sex-influenced esterase
seychellene: from the essential oil of indian valerian (valeriana jatamansi)
sezolamide: decreases intraocular pressure, topically in vivo; inhibits carbonic anhydrase; rn given refers to parent cpd without isomeric designation
sfa-1 protein, C elegans: belongs to the family of signal transduction & activator of rna proteins; refseq nm_070632
sfericase: serine protease from bacillus sphaericus, has 2 undializable calcium ions
sfl protein, Drosophila: a [heparan sulfate]-glucosamine n-sulfotransferase involved in tracheal cell migration
sfu proteins, Serratia marcescens: amino acid sequences given in first source; involved in a periplasmic-binding protein-dependent iron transport mechanism
sgm protein, Micromonospora zionensis: catalyzes the methylation of 30s ribosomal units to confer sisomicin-gentamicin resistance in micromonospora zionensis
sh2d4a protein, mouse: glomerulus-associated protein, transcribed solely by podocytes
shaggy-related protein kinase eta, Arabidopsis: a component of the brassinosteroid signalling pathway
shanchol: an oral vaccine derived from bivalent o1 and o139 strains without the ct b subunit
shank2E protein, rat: binds nap(i) cotransporter at the apical membrane of proximal tubule cells; a spliceoform of a family of pdz proteins that is concentrated at the apical domain of liver and pancreatic epithelial cell types and is expressed in kidney
shankhpushpi: an ayurvedic medicine with anxiolytic, antidepressant, and memory enhancing activities; prepared from convolvulus pluricaulis, evolvulus alsinoides, or clitoria ternatea
shao yao decoction: composed of radix paeoniae alba, radix angelicae sinensis, rhizoma coptidis, semen arecae, radix aucklandiae, radix et rhizoma glycyrrhizae, radix et rhizoma rhei, radix scutellariae, cortex cinnamomi; ameliorates colitis-associated colorectal cancer
shaoyao gancao decoction: composed of paeoniae radix (shao-yao), glycyrrhizae radix (gan-cao), panax notoginseng (san-qi), radix angelicae sinensis (dang-gui), and rhizoma corydalis (yanhu-suo)
shark cartilage extract: has antiangiogenic properties & potential role in the treatment of psoriasis
sharkquinone: from marine-derived streptomyces sp. egy1 with trail resistance-overcoming activity
sharpin: postsynaptic density protein; directly interacts with shank family of proteins; genbank af203906
shashen-maidong decoction: composed of ophiopogon japonicus, glehnia littoralis, lablab purpureus, morus alba l, polygonatum odoratum (mill.) druce, trichosanthes kirilowii maxim, glycyrrhiza uralensis fisch
shea oleine: an oil fraction derived from the nut of the tree butyrospermum parkii, which grows in central and western africa; used as a frying oil and, after hardening, in margarine and toffee fat
shearinine D: isolated from the marine-derived strain of the fungus penicillium janthinellum biourge
shearinine E: isolated from the marine-derived strain of the fungus penicillium janthinellum biourge
shearinine F: isolated from the marine-derived strain of the fungus penicillium janthinellum biourge
sheath degrading enzyme: an enzyme with either hydrolytic or polysaccharide eliminase activity that catalyzes the degradation of sphaerotilus natans sheath
shellolic acid A: has antibacterial activity; isolated from shellac secreted by kerria lacca
shemamruthaa: has antineoplastic activity; consists of phyllanthus emblica and hibiscus rosa-sinensis
shen-zhi-ling: 10 types of tcm components: codonopsis pilosula, cassia twig, paeonia lactiflora, honey-fried licorice root, poria cocos, rhizoma zingiberis, radix polygalae, acorus tatarinowii, ossa draconis and concha ostreae
sheng-ma-ge-gen-tang: used against pediatric viral infection; composed of pueraria lobata, paeonia lactiflora, cimicifuga foetida, glycyrrhiza uralensis, and zingiber officinale
shengbai decoction: included six kinds of traditional chinese medicine: ren shen (panax ginseng c. a. mey), huang qi (radix astragali seuhedysari), shu di (rehmannia glutinosa), dang gui (radix angelica sinensis), bai shao (paeonia lactiflora pall), and chuan xiong (rhizoma ligustici)
shenghe: reverses multidrug resistance of gastric carcinoma; constituent herbs listed in first source
shengqifuzheng: promotes the recovery of b cells in gut-associated lymphoid tissues of mice treated with cyclophosphamide
shengqing: down-regulates nf-kappab expression; helps prevent gallstone formation and inflammation of the biliary tract
shengyu: used for treating brain dysfunction; isolated from panax ginseng, astragalus membranaceus, angelica sinensis; paeonia lactiflora, ligusticum chuanxiong, and rehmannia glutinosa
shenhua: has anti-inflammatory activity; consists of astragalus membranaceus, ligustrum lucidum, atractylodes macrocephala, curcumae phaeocaulis, lonicera japonica, paeonia lactiflor, and sparganium stoloniferum
shenkang: could inhibit hypertrophy of glomerular mesangial cells cultured in high glucose partly through inhibiting overexpressions of p2l mrna, p21 and p27 protein
shenkangning capsule: consists of of eight chinese medicinal herbs including astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, poria cocos (schw) wolf., alisma orientale (sam.) juz., leonurus japonicus houtt., cynomorium songaricum rupr., dioscorea opposita
shenle: used to reduce proteinuria and tcm syndrome in patients with iga nephropathy
shenling baizhu san: contains herbs: panax ginseng, atractylodes ovata, poria cocos, dioscorea batatas, dolichos lablab, coix lacryma-jobi, nelumbo nucifera, glycyrrhiza uralensis fisch, platycodon grandiflorum, and amomum xanthioides in a ratio of 5':'5':'5':'5':'4
shenqi: for the treatment of idiopathic membranous nephropathy; comprised of astragalus membranaceus, angelica sinensis, atractylodes chinensis, atractylodes macrocephala, dioscorea opposita, polyporus umbellatus, poria cocos, bombyx mori, hedyotis diffusa, coix lacryma-jobi, codonopsis pilosula, salvia miltiorrhiza, and whitmania pigra
shenqinmycin: isolated from metabolite of pseudomonas sp.; has antifungal activity
shenqui-wan: antioxidant; contains rehmanniae radix, dioscorae radix, corni fructus, alimatis rhizoma, moutan cortex radicis, hoelen, maximowicziae fructus and cervi cornu
shenshao: consists of radix salviae miltiorrhizae, astragalus membranaceus, radix paeoniae rubra, radix angelicae sinensis, rhizoma chuanxiong, semen persicae, flos carthami, pheretima aspergillum, hirudo , and rhizoma pinelliae
shenshuai yangzhen: can improve malnutrition and reduce renal damage in rats with renal insufficiency
shensongine A: alkaloid from anti-arrhythmic shensong yangxin capsule
shentong zhuyu: consists of radix gentianae macrophyllae, rhizoma ligusticum wallichii, semen juglandis, flos carthami, radix glycyrrhizae, rhizoma et radix notopterygii, myrrha, radix angelicae sinensis, faeces trogopterori, rhizoma cyperi, radix achyranthis bidentatae, and pheretima
shenxinning: used to improve cardiac remodeling; isolated from rhubarb, salvia miltiorrhiza, semen persicae, radix astragali, hartshorn, radix curcumae, and rhizoma smilacis glabrae
shenyan kangfu: used to treat diabetic nephropathy; consists of american ginseng, ginseng, rehmannia glutinosa, eucommia ulmoides, chinese yam, oldenlandia diffusa, black bean, poria cocos, leonurus, radix salviae miltiorrhizae, and cogongrass rhizome