NLK-NML/MeSH-CZ-2025-notes huggingface dataset:
anti-thyroglobulin: autoantibody to thyroglobulin present in serum; its presence was measured in attempt to correlate immuno-epidemiological indices in malaria
anti-treponemal lymphotoxin: mw 65,000; fully characterized; produced by spleen lymphocytes of syphilitic rabbit; not an anti-treponemal antibody; exerts a direct killing effect on treponema pallidum
antiadipositum X 112: contains cathine hcl, nikethamide, caffeine, sodium salicylate & nineteen other low-dose herbal ingredients
antiamoebin: antiprotozoal, anthelmintic antibiotic produced by the fungus emericellopsis poonensis thirum
antiarrhythmic peptide: atrial peptide from bovine atria; hexapeptide composed of hydroxyproline(1), proline(1), glycine(3) & alanine(1); both n-terminal & carboxy-terminal residues are glycine
antibacterial polypeptide LCI: antibacterial polypeptide lci expressed in escherichia coli
antibiotic 1233A: beta-lactone antibiotic from cephalosporium; hydroxymethylglutaryl-coa synthase & 3c protease, viral inhibitor
antibiotic 460: from micromonospora, m. chalcea var, flavida (nrrl 3222)
antibiotic 6643-X: from streptomyces sp. kc-6643
antibiotic 80334 C: isolated from actinosporangium xiangfanensis
antibiotic 80334 F: isolated from actinosporangium xiangfanensis
antibiotic A447 C: isolated from a strain of streptomyces cyaneus
antibiotic A447 D: isolated from a strain of streptomyces cyaneus
antibiotic AC6H: from micromonospora carbonaceae; the cpd belongs to the tetrocarcin group of antibiotics
antibiotic AFC-BC11: isolated from burkholderia cepacia; amino acid ; genbank af076477
antibiotic AK 165-3: from streptomyces hygroscopicus; contains a guanidine group in the molecule
antibiotic AS 40: macrolide antibiotic from streptomyces as-40
antibiotic C 19393E5: from streptomyces griseus subsp. cryophilus
antibiotic G0069A: a clavam peptide produced by a streptomyces strain isolated from a soil sample collected in yunnan province, china
antibiotic H107: an aminoglycoside anti-pseudomonas antibiotic produced by spirillospora
antibiotic JI 20A: see also antibiotic complex ji-20 & ji-20b
antibiotic JI 20B: see also antibiotic complex ji-20 & ji-20a
antibiotic PS 6: do not confuse with ps-6, a propanolamine
antibiotic SS 56C: isolated from culture broth of streptomyces eurocidicus
antibiotic complex JI-20: close structural similarity with gentamycin b; see also antibiotic ji-20b & antibiotic ji-20a
antibiotics M-4365: series of macrolide antibiotics of which rosamicin is a member; used for photoinduced affinity labeling of e coli ribosomes; rn given refers to cpd with unknown mf; see also record for de-epoxy rosamicin (antibiotic m-4365 g2)
antibody 28B4: catalyzes the periodate-dependent oxidation of sulfide to sufloxide; partial amino acid
antibody GD3G7, human: antibody gd3g7 identified rare cs-e-like structures that were strongly expressed in ovarian adenocarcinomas. this antibody might therefore be instrumental for identifying tumor-related cs alterations
antibody MDXH447: a bispecific antibody with specificity for the high affinity igg receptor (cd64) and the type i epidermal growth factor receptor type (egf-r)
antibody aldolase: prepared by reactive immunization to catalyze a wide variety of aldol reactions and decarboxylations
anticancer principle GCE: from gymnosporia rothiana laws; has in vitro cytotoxicity against p-388 & l-1210 tumor cells
anticentromere antibody: antibody to centromere (kinetochore) that reacts with centromeric regions of chromosomes derived from humans, mice, and chinese hamsters; present in high frequency in the calcinosis/raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (crest) of scleroderma
antichymotrypsin II: from bombyx mori; contains 375 amino acids; amino acid sequence given in first source
anticoagulant factor Xa protein, Aedes aegypti: from yellow fever mosquito, aedes aegypti; mw 48 kda; amino acid
anticoagulant peptide 5, Ancylostoma caninum: genbank u30795
anticoagulant protein, Ancylostoma caninum: a hookworm-derived inhibitor of human coagulation factor xa; n-terminal amino acid sequence given in first source; genbank u18305
anticoagulant protein, Streptomyces cinnamoneus: inhibits blood coagulation; mw around 12,000 da; sac i, ii, and iii differ only in their amino-terminal sequences; amino acid sequence of sac i given in first source
anticoagulation factor I, Agkistrodon acutus: from the venom of agkistrodon acutus
anticoagulation factor II, Agkistrodon acutus: from the venom of agkistrodon acutus
anticomplement: in serum of children with protein-calorie malnutrition; do not use /antag
antidiuretic hormone water channel protein, Bufo: molecular mass of 53-55 kda; amino acid compositions of 55-, 53-, & 17-kda adh water channel components given in first source
antiegressin, Trypanosoma cruzi: acts late in the intracellular growth cycle of trypanosoma cruzi to inhibit parasite egress
antiflammin P1: nonapeptide fragment of uteroglobin has no phospholipase a2 inhibitory & anti-inflammatory activity; rn given refers to all (l)-isomer
antiflammin P2: nonapeptide fragment of lipocortin i; has no phospholipase a2 inhibitory & anti-inflammatory activity; rn given refers to all (l)-isomer
antifreeze protein precursor: produced by certain marine fish that are threatened by ice contact; studied in drosophila melanogaster; contains 59 amino acids; the preproprotein contains 82 amino acids& the mature protein is 37 amino acids long; amino acid sequence given in first source
antifreeze protein, Myoxocephalus scorpius: alanine-rich, alpha-helical antifreeze protein; amino acid
antifungal protein, Aspergillus: inhibits growth of filamentous fungi; isolated from aspergillus; has been sequenced
antifungal protein, Sarcophaga peregrina: a novel his-rich 67 amino acid residue antifungal protein from the hemolymph of flesh fly, s. peregrina; repressed growth of candida albicans; amino acid sequence given in first source; genbank d13797; do not confuse with anterior fat body protein (aka afp protein, sarchophage peregrina)
antigastrin: inhibits the effect of gastrin & pentagastrin in rats & dogs; rn given refers to parent cpd
antigen 11.1, Plasmodium falciparum: contains 22 repeats of 9 amino acids; antibodies to the 9 amino acid units cross react with human serum albumin; amino acid sequence has been determined
antigen 113, Plasmodium falciparum: a gpi-anchored protein that has been so far localized at the surface of merozoites
antigen 117, Dictyostelium: surface antigen, glycoprotein from dictyostelium discoideum of 69 or 72kda mw; a cell adhesion molecule
antigen 12D3: localised to both the apical complex of the merozoite and the cytoplasm of the parasitised erythrocyte; amino acid sequence known
antigen 1870, Neisseria meningitidis: a promising vaccine candidate for prevention of meningococcal group b disease caused by gna1870 variant 1 strains; amino acid
antigen 24.1-kDa, Mycobacterium tuberculosis: a secreted lipoprotein involved in cellular immunity; amino acid
antigen 3008, Plasmodium chabaudi: a plasmodium chabaudi antigen located in the parasitophorous vacuole membrane; mw about 24 kda; amino acid sequence has been determined
antigen 35, Mycobacterium avium: homolog of m. leprae; amino acid
antigen 3G11, mouse: loss characterizes a distinct population of anergic/regulatory t cells in experimental autoimmune encephalomyelitis
antigen 40-kDa, Mycobacterium avium: a highly conserved mycobacterial antigen in is901(+) mycobacterium avium; genbank af247653
antigen 43, E coli: outer membrane protein of escherichia coli structurally resembles the immunoglobulin a1 protease class of exported protein; amino acid
antigen 4C5: a neuron-specific surface antigen expressed during development and after injury; recognized by monoclonal antibody 4c5
antigen 5, Echinococcus granulosus: is a 67 kda glycoprotein one of the most valuable e. granulosus antigens
antigen 5, Polybia scutellaris: candidate for vespid allergy immunotherapy; amino acid
antigen 7A6: a mitochondrial membrane protein defined by a monoclonal antibody is preferentially detected in apoptotic cells
antigen 7H6: a 155-175 kda protein associated with tight junctions of epithelium
antigen 84, Mycobacterium: rn refers to m. tuberculosis; a mycobacterial antigen; mw 34 kda; amino acid sequence given in first source; genbank x77129 (m. tuberculosis), x77128 (m. leprae)
antigen 85, Mycobacterium bovis: amino acid sequence given in first source; antigen 85 complex is made up of components a, b, and c
antigen 85A, Mycobacterium gordonae: a mature protein of 296 amino acids
antigen 85A, Mycobacterium tuberculosis: a major immunologic antigen part of antigen 85 complex; used in the vaccine formulation against tuberculosis
antigen 85A, Mycobacterium ulcerans: from mycobacterium bovis bcg against buruli ulcer; amino acid
antigen 85B, Mycobacterium leprae: a 17-amino acid peptide from mycobacterium lepare antigen 85 complex which shows fibronectin-binding activity & may afford protective immunogenicity; amino acid sequence given in first source
antigen 85B, Mycobacterium paratuberculosis: the data suggest a plausible mechanism of ag-specific t-cell responses in colitis driven by potent ags conserved in mycobacterium species
antigen 85B, Mycobacterium tuberculosis: amino acid sequence given in first source; mycobacterial antigen 85b is highly conserved within different species
antigen 987P, E coli: from enterotoxigenic escherichia coli; has been sequenced
antigen A, Mycobacterium paratuberculosis: partial amino acid sequence given in first source
antigen A2B7, honeybee: a 91kda surface antigen expressed in adult & developing honeybee of olfactory pathway
antigen B, Echinococcus: a 160 kda thermostable lipoprotein from echinococcus granulosus metacestodes; genbank z26336
antigen B, Echinococcus granulosus: an oligomeric 70-130 kda lipoprotein
antigen BLA.36, human: associated with hodgkin's disease; expressed by t-cell lines derived from anaplastic large cell lymphomas (alcl) and lymphomatoid papulosis
antigen CD63b, human: is a surface antigen expressed on human neutrophils. its expression is enhanced by pacap
antigen CYFRA21.1: a cytokeratin related marker, serum concentrations of which show promising diagnostic utility in patients with bladder cancer
antigen D, Mycobacterium paratuberculosis: mw 400 kda; n-terminal amino acid given in first source
antigen Dlx-2: expressed in the developing forebrain; rn refers to human c-terminal fragment
antigen FORSE-1: a cell surface proteoglycan-like antigen; exhibits regional specificity in the developing rat centeral nervous system; recognized by monoclonal antibody forse-1
antigen G250: renal cell carcinoma-associated antigen g250 encodes a human leukocyte antigen (hla)-a2.1-restricted epitope recognized by cytotoxic t lymphocytes
antigen GL7: an activation antigen expressed by in vitro-stimulated b & t cells as well as by a subpopulation of thymocytes; recognized by mab gl7
antigen I(17), Trypanosome: a diagnostically useful antigen from flagellar cytoskeleton of african trypansomes; genbank z36281
antigen I(2), Trypanosome: a diagnostically useful antigen from flagellar cytoskeleton of african trypanosomes; amino acid sequence given in first source; genbank z36280
antigen KH-1: a potential anticancer vaccine kh-1 adenocarcinoma antigen
antigen Kp 90: detected in 78% of serum and 69% of body fluids from patients with active tuberculosis
antigen LEC-A: encoded by a defective endogenous retroviral sequence of the intracisternal a particle (iap) family; recognized by syngeneic cytolytic t lymphocytes in mouse spontaneous leukemia; amino acid sequence given in first source
antigen LG2-C, human: one of the several antigens expressed by melanoma line lg2-mel which results from a point mutation in gene os-9 & recognized by autologous ctl; amino acid sequence is kelegilll
antigen NU-T2 DEJ: a primate-specific antigen of the dermal-epidermal junction
antigen PIM, Theileria parva: a neutralizing antigen of theileria parva; mw 62-112 kda; amino acid sequence given in first source
antigen Pf11-1, Plasmodium falciparum: a gametocyte-specific antigen involved in the erythrocyte rupture during gametogenesis; composed of tandem repeats of 9 amino acid; amino acid sequence given in first source
antigen Pf332, Plasmodium: amino acid sequence given in first source; a giant protein (mw 2.5 mda) that is translocated from the parasite to the membrane of infected erythrocytes
antigen RhLA-DR: expressed on hematopoietic cells of rhesus monkey
antigen SPAM-H1, Plasmodium falciparum: spam - secreted polymorphic antigen associated with merozoites; from plasmodium falciparum; amino acid sequence given in first source
antigen Sm10, Schistosoma: a 10kda t cell-stimulating antigen associated with protective immunity in humans; amino acid sequence given in first source; genbank x98619
antigen Sm23, Schistosoma: closely resembles melanoma antigen me491; amino acid sequence given in first source
antigen T cell receptor, eta-kappa: alternatively spliced product of the tcr zeta chain, identical to tcr eta chain; amino acid ; genbank u56258 (mouse)
antigen T cell receptor, iota chain: a type-i integral membrane protein; mw 17,670 da; isoelectric point 9.2; an alternatively spliced product of tcr zeta; amino acid sequence given in first source; genbank x84237
antigen T cell receptor, zeta chain: amino acid sequence given in first source; component of the t3 antigen complex; non-glycosylated transmembrane protein in mouse and human
antigen V, Pseudomonas: homolog of yersinia v antigen; immunization with antigen protects against type iii intoxication & lung injury
antigen X-80: plays an important role in growth and differentiation during oogenesis and spermatogenesis
antigen gp 160(6C3): monoclonal antibody-defined b-lineage transformation antigen; specifically identifies abelson-diseased animals
antigen gp195, Plasmodium: mw 195kda; major merozoite surface antigen from plasmodium falciparum; synthesized during late erythrocytic stage of development & proteolytically processed to lower molecular weight fragments; amino acid sequence given in first source
antigen p102: acidic, mannose-containing membrane glycoprotein of mr 102,000 da detected in human sarcomas using murine igg1 monoclonal antibody 23-26
antigen p200: a cell surface monomeric protein of mw 200 kda; expressed in human sarcoma cell lines; detected by moab 29-13-17
antigen pso p27: a psoriasis-associated antigen; n-terminal amino acid sequence given in first source
antigen-specific helper factors: soluble product of t helper cells, binds antigen and can induce b-cell and cytotoxic t-lymphocyte differentiation; its relationship to the t-cell surface antigen receptor is unknown
antigenic factor 9: found in the mannan of candida guilliermondii; contains beta-1,2 and alpha-1,6 linkages
antigenic peptide Ealpha52-68: covalently linked to beta chain of mhc class ii molecule i-a(b)
antigenic protein, guerin epithelioma, neoplasm: amino acid & carbohydrate composition given in first source; mw 61-66kda
antigens, CD200: neuronal membrane glycoprotein recognized by mrc ox-2 monoclonal antibody; mw 41,000 from brain & mw 47,000 from thymocytes; do not confuse with cd 200, a dental ceramic
antiglomerular basement membrane antibody: used in inducing glomerulonephritis in animals as a model of immune renal injury
antigrippen: russian drug; for treatment of influenza; contains acetylsalicylic acid; ascorbic acid; calcium lactate; benadryl; rutin
antihemorrhagic factor: purified serum factor in snakes which inhibited hemorrhagic principles in venoms
antiherpin: contains vaccinia virus soluble antigens; for treatment of recurrent genital herpes
antilipopolysaccharide antibodies: used to treat patients in septic shock or with septic arthritis; see also record for antilipopolysaccharide factor (limulus)
antilipopolysaccharide factor (Limulus): potent anticoagulant which inhibits the endotoxin-mediated activation of limulus coagulation system; mw appr. 10,000
antillatoxin: a neurotoxic lipopeptide from marine cyanobacterium, lyngbya majuscula
antillatoxin B: from the marine cyanobacterium lyngbya majuscula
antimicrobial hybrid peptide CM15: a small 15-residue synthetic hybrid peptide composed of the first seven residues of the silk moth amp cecropin a and residues 2-9 from the bee venom peptide, mellitin
antimicrobial peptide 1, Lippia sidoides: a botryticidal peptide isolated from rosemary pepper
antimicrobial peptide 2, Lippia sidoides: a botryticidal peptide isolated from rosemary pepper
antimicrobial peptide AG-30: a synthetic antimicrobial peptide with angiogenic properties; do not confuse with tyrphostin ag-30
antimicrobial peptide CGA-N12: amino acid sequence from 65th to 76th residue of the n-terminus of chromogranin a
antimicrobial peptide DGL13K: gkiiklkaslkll-nh2
antimicrobial peptide IB-367: a structural analog of protegrin-1; reduces the local microflora densities & may improve clinical outcomes in patients at risk for the development of oral mucositis
antimicrobial peptide V4: v4 is designed based on a known amphipathic cationic pattern bhphb (b: basic; h: hydrophobic; p: polar residue, respectively) and shows a good combination of high antimicrobial activity, low cytotoxic activity and low hemolytic activity
antimicrobial peptide m2163, Lactobacillus casei: can trigger apoptosis in the human colorectal cancer cell line sw480
antimicrobial peptide m2386, Lactobacillus casei: can trigger apoptosis in the human colorectal cancer cell line sw480
antimicrobial peptide, PGAa: amphipathic antimicrobial synthetic peptide; amino acid
antimicrobial peptide, Pharbitis: from seeds of morning glory, pharbitis nil; amino acid sequence given in first source; homologous with hevein
antimony pentoxide: used for determination of manganese in tissue; rn given refers to parent cpd
antimony(V) phosphate: inorganic ion exchanger suitable for the selective adsorption of cadmium & mercury
antineoplastin I: a putative no-generating agent, of m(r) 5 kda prepared from aqueous extract of bovine pancreas
antineoplaston A2: mixture of small peptides and amino acid derivatives isolated from human urine; protects against neoplastic growth
antineoplaston A3: oxidized mixture of small and medium peptides and amino acid derivatives isolated from human urine; inhibits growth of cancer cells
antineoplaston A5: mixture of small to medium size peptides and amino acid derivatives isolated from human urine; used in therapy of human breast cancer and leukemia
antineoplaston AS 2-1: a mixture of sodium salts of phenylacetic acid and phenylacetylglutamine in the ratio 4:1
antioquine: ; bisbenzylisoquinoline alkaloid isolated from pseudoxandra sclerocarpa
antiostatin A1: a potent carbazole-based naturally occurring antioxidant from streptomyces cyaneus
antioxidant biofactor AOB: a phenol-rich processed grain food, extracted from soybeans, wheat, rice bran, malted rice, tear grass, green leaves & citron (complete list of ingredients in first source); has superoxide-scavenging properties; aob treatment considerably improved the antioxidant defenses
antiperinuclear factor: detected by indirect immunofluorescence on smears of human buccal mucosa cells in 92% of rheumatoid arthritis cases
antiplasmin-cleaving enzyme, human: a 97 kda plasma proteinase that potentiates alpha2-antiplasmin inhibition of fibrin digestion; apce cleaves met-alpha(2)ap to the derivative asn-alpha(2)ap, which is more efficiently incorporated into fibrin and consequently makes it strikingly resistant to plasmin digestion
antiproliferative factor APF, human: expressed in patients with interstitial cystitis; inhibits bladder cell proliferation; related to frizzled-8
antiprotease C-II: low mw soybean antiprotease which behaves as outstandingly suitable substrate model casein kinase ts
antiprothrombinase: spontaneously acquired anticoagulant found in patients with systemic lupus erythematosus
antisecretory factor: isolated from pituitary glands of rats, pigs, and humans, as well from the intestinal mucosa of rats and pigs; inhibits cholera-toxin induced intestinal hypersecretion; protein isolated from porcine pituitary gland had molecular weight of 60kd
antiseminalplasmin, Bos taurus: contains three proteins, one with rnaase activity, one with proteinase activity & one one with no proteinase activity; from bovine seminal plasma; antagonist of seminalplasmin
antismoke mouthwash 881010: contains 0.5% silver nitrate as active ingredient
antistasin: from the salivary gland of the mexican leech haementeria officinalis; has both antimetastatic & coagulant activities
antistreptohyaluronidase: this is not an enzyme, but an enzyme inhibitor; russian drug
antitac(FV)-PE38 recombinant immunotoxin: labeled with in(111), a 3- to 4-fold decrease in cytotoxicity observed
antiterminator proteins, Bacteria: rna-binding protein from bacteria; amino acid sequence has been determined
antithrombin BM protein, human: from human plasma; binds only moderately to heparin; mw 70,000; different from antithrombin iii & heparin cofactor a
antithrombin Barcelona 2: abnormal antithrombin; arg replaced by cys at position 47
antithrombin Cambridge II: abnormal antithrombin; ala replaced by ser in position 384; causes minor but consistent decrease in heparin-induced thrombin inhibition
antithrombin Chicago: functionally inactive antithrombin variant; arg replaced by his at position 393
antithrombin III Arg197STOP: arg(197) codon replaced by stop codon tga (r197x); one of two mutations responsible for hereditary type ia antithrombin iii deficiency
antithrombin III Avranches: antithrombin ii variant; has defective serine-protease inhibition
antithrombin III Barcelona: abnormal at iii characterized by a lack of affinity for heparin; present in heterozygous state
antithrombin III Barcelona 2: molecular variant of at iii characterized by a lack of affinity for heparin but no changes to its isoelectric point
antithrombin III Basel: hereditary abnormal antithrombin; proline replaced by leucine in position 41; has impaired heparin cofactor activity
antithrombin III Budapest 2: pathological variant displaying abnormal reaction with heparin was designated at iii budapest 2
antithrombin III Cambridge: abnormal antithrombin; proline substituted for alanine at position 384; has reduced heparin & progressive inhibitory activity
antithrombin III Charleville: functional abnormal antithrombin iii which forms unstable complexes with thrombin
antithrombin III Clichy: abnormal antithrombin with low heparin affinity
antithrombin III Denver: abnormal mutant protein with defective serine protease binding; serine 394 replaced by leucine
antithrombin III Dublin: abnormal antithrombin; mutant has amino acid substitution which gives it a more basic molecule that is clinically silent at the coagulation level; found in increased frequency in children with cancer
antithrombin III Dublin 2: abnormal antithrombin; marginally decreased heparin reactivity
antithrombin III Fontainebleau: variant with heparin cofactor activity close to 50% of normal
antithrombin III Franconville: abnormal antithrombin iii; variant with pro 41 leu mutatuion; causes defective heparin cofactor activity
antithrombin III Geneva: familial abnormal antithrombin with defective heparin cofactor activity
antithrombin III Glasgow: abnormal antithrombin with increased heparin affinity & reduced ability to inactivate thrombin; associated with familial thrombosis; tryptic peptides ala(371)-arg(393) & ser(394)-arg(399) present in reduced amounts; asp(187) replaced by lys
antithrombin III Hamilton: ala 382 replaced by thr; acts as a substrate but not an inhibitor of alpha-thrombin & factor xa
antithrombin III Kumamoto: antithrombin iii variant that lacks affinity for heparin
antithrombin III Milano: hereditary abnormal antithrombin; characterized by an increased affinity for heparin and a total lack of reactivity with thrombin
antithrombin III Nagasaki: abnormal antithrombin iii containing a ser(116) to pro mutation; lacks affinity for heparin
antithrombin III Northwick Park: variant antithrombin with normal affinity for heparin but reduced heparin cofactor activity
antithrombin III Padua: abnormal antithrombin iii characterized by abnormal migration in agarose heparin; arg 47 replaced by his
antithrombin III Padua(2): significantly different from antithrombin iii padua
antithrombin III Paris: familial antithrombin iii variant characterized by a reduced affinity for heparin
antithrombin III Roma: abnormal antithrombin which contains pathological at iii isoforms; has no affinity for heparin
antithrombin III Rouen: hereditary abnormal antithrombin; has heparin-binding defect; arg at position 47 is replaced by his; same mutation reported in at iii rouen and at iii bligny
antithrombin III Sheffield: abnormal antithrombin; arg is relaced by his at position 393 at the reactive site; causes thrombosis
antithrombin III Stockholm: a structural mutant with normal heparin affinity but impaired serine protease activity; gly 392 replaced by asp
antithrombin III Sudbury: ala 384 replaced by pro; abnormal thrombin-binding activity & thrombotic diathesis
antithrombin III Tours: abnormal antithrombin; arginine 47 replaced by cysteine
antithrombin III Toyama: familial abnormal antithrombin iii characterized by low heparin cofactor & recurrent thrombophlebitis
antithrombin III Trento: abnormal antithrombin pattern only in absence of heparin
antithrombin III Vicenza: dysfunctional antithrombin iii characterized by low activity & abnormal pattern of serum two-dimensional crossed immunoelectrophoresis in presence of heparin
antithrombin III-protease complex: found in 46% of patients with disseminated intravascular coagulation
antithrombin La Rochelle: genes for antithrombin and factor v are located at chromosome 1q23. the molecular data and phenotypic behaviour in this family are strongly suggestive of allelic co-segregation of the mutant alleles
antithrombin Morioka: cys 95 replaced by arg; a missense mutation causing type i antithrombin deficiency
antithrombin Okayama: has abnormal antithrombin causing type i at deficiency; has a 4-base pair deletion within exon 2 resulting in a new reading frame starting at thr 61 and a premature stop codon (tga) at position 80 in the amino acid sequence
antithrombin Pescara: arginine at position 393 is replaced by proline; causes thrombosis
antithrombin Rouen-VI: an antithrombin variant with asn at position 187 replaced by asp
antithrombin V: pathological inhibitor or coagulation as an accompanying symptom of various diseases
antithrombin Wibble: methionine replaces threonine at position 85
antitumor-analgesic peptide, Buthus martensii: an antitumor-analgesic peptide (agap) from the venom of chinese scorpion buthus martensii; has been sequenced
antivitamins K: antivitamins k are derivatives of 4-hydroxycoumarin or indane-1,3-dione
antixol: mixture of proteins, unspecified lipoproteins, cellulose esters and triethanolamine salt; used as a barrier cream
antlermicin B: from micromonospora chalcea subsp. kazunoensis; see also antlermicin a & antlermicin c
antlermicin C: from micromonospora chalcea subsp. kazunoensis; see also antlermicin a & antlermicin b
antoksyd S: consists primarily of baicalin and baicalein; derived from scutellaria baicalensis
antramin: secreted by pylorus; consists of histamine & 3 amino acids inhibits gastrin and somatostatin
antrimycin: from streptomyces xanthocidicus mg125-cf1
antrocinnamomin A: from the mycelia of antrodia cinnamomea with nitric oxide inhibitory activities in macrophages
antrocinnamomin B: from the mycelia of antrodia cinnamomea with nitric oxide inhibitory activities in macrophages
antrocinnamomin C: from the mycelia of antrodia cinnamomea with nitric oxide inhibitory activities in macrophages
antrocinnamomin D: from the mycelia of antrodia cinnamomea with nitric oxide inhibitory activities in macrophages
antrodin F: from fermentation of the basidiomycete antrodiella albocinnamomea
antrolactone A: from antrodia heteromorpha, with inhibitory effects on rankl-induced osteoclastogenesis
antrolactone B: from antrodia heteromorpha and their inhibitory effects on rankl-induced osteoclastogenesis
antrolone: benzoid derived from medicinal mushroom antrodia cinnamomea; has anti-inflammatory properties
antrosterol: a bioactive constitute of sterols in edible antrodia camphorata submerged whole broth
aoba alcohol xylopyranosyl-(1-6)-glucopyranoside: from leaves of alangium platanifolium
aogacillin A: capable of overcoming arbekacin resistance in methicillin-resistant staphylococcus aureus (mrsa), isolated from a culture broth of simplicillium sp. fki-5985
aogacillin B: capable of overcoming arbekacin resistance in methicillin-resistant staphylococcus aureus (mrsa), isolated from a culture broth of simplicillium sp. fki-5985
apabetalone: a bromodomain and extra-terminal domain protein (bet) inhibitor; prevents interactions between bet proteins and acetyl-lysine residues on histone tails to modify epigenetic regulation
apakaochtodene A: apakaochtodenes a and b are two tetrahalogenated isomeric monoterpenes from the red marine alga portieria hornemannii
apalbumin 1, honeybee: major honeybee royal jelly and honey glycoprotein with immunostimulatory effect on tnfalpha release; mw 55 kda; has been sequenced
apararenone: non-steroidal compound with mineralocorticoid receptor agonist activity
apatinib: reverses multidrug resistance by inhibiting the efflux function of multiple atp-binding cassette transporters
apatorsen: an antisense oligonucleotide that targets hsp27 for support of cancer therapy
apc protein, zebrafish: antagonist of the wnt/beta-catenin pathway; binds beta-catenin and axin; refseq nm_001143840
apelin-13, Ala(13)-: an agtrl1 antagonsit
apelin-14: synthetic analog of apelin-13; used to form liposomes that target endothelial cells
aph(2')-Ib protein, Enterococcus faecium: has been sequenced; genbank af207840
aph-2 protein, C elegans: nicastrin homolog; an extracellular protein required for glp-1 mediated signaling; amino acid
aphanamixoid A: a potent defensive/antifeedant from aphanamixis polystachya
aphanamixoid B: a potent defensive/antifeedant from aphanamixis polystachya
aphanamolide A: cytotoxic compound from the seeds of aphanamixis polystachya
aphanamolide B: cytotoxic compound from the seeds of aphanamixis polystachya
aphantoxin: from blue-green algea; blocks sodium conductance of squid axon membrane with no effect on potassium conductance
aphelaketotriol: a hemolytic polar steroidal constituent of the starfish, aphelasterias japonica
aphelandrine: rn given for (3s-(3r*,3ar*,15r*))-isomer
aphelasteroside C: a hemolytic polar steroidal constituent of the starfish, aphelasterias japonica
aphid transmission factor, Cauliflower mosaic virus: an 18 kda protein from cauliflower mosaic virus (camv) involved in virus aphid (vector) transmission; amino acid sequence has been determined
aphidicolan-16beta-ol synthase: involved in cyclization of geranylgeranyl diphosphate to aphidicolan-16beta-ol; genbank ab049075
apholate: was mh 1972-92 (see under azirines 1972-90); use aziridines to search apholate 1972-92
aphrodisin protein, Mesocricetus auratus: mw 17 kda protein from hamster vaginal discharge; aphrodisiac pheromone
apical membrane antigen I, Plasmodium: involved in the merozoite invasion of erythrocytes; from five plasmodium species; amino acid sequence given in first source
apicortin protein, Plasmodium falciparum: refseq xm_002808649.1
apidaecin: isolated from lymph fluid of honeybee; amino acid sequence given in first source; not antibiotic, since it does not come from microorganism
apigenin 4'-O-alpha-D-glucopyranoside: from elsholtzia rugulosa hemsl
apigenin 4'-O-beta-D-glucopyranosyl-(1''-4')-O-beta-D-glucopyranoside: immunomodulator from callistemon viridiflorus leaves
apigenin 5-O-rhamnopyranosyl(1''''2'')(6''-O-acetyl)glucopyranoside: an inhibitor of osteoclast differentiation from cephalotaxus koreana
apigenin 6,8-digalactoside: from roots of stellaria dichotoma
apigenin 6-C-(xylopyranosyl-1'''-2''-galactopyranoside)-7-O-(6''''-O-4-coumarylglucopyranoside): isolated from the seeds of syzygium aromaticum
apigenin 6-C-(xylopyranosyl-1'''-2''-galactopyranoside)-7-O-glucopyranoside: isolated from the seeds of syzygium aromaticum
apigenin 6-C-alpha-arabinofuranosyl 8-C-alpha-arabinopyranoside: from bulbophyllum retusiusculum
apigenin 6-C-beta-D-fucopyranosyl-7-O-beta-D-glucopyranoside: antioxidant from bamboo (neosinocalamus affinis) leaves
apigenin 6-C-rhamnopyranoside-8-C-(6'''-(3-hydroxy-3-methylglutaroyl)glucopyranoside): isolated from glycyrrhiza eurycarpa
apigenin 7-O-(6-O-malonylglucoside): vacuolar pigment from parsley (petroselinum)
apigenin 7-O-alpha-L-2,3-di-O-acetylrhamnopyranosyl-(1-6)-beta-D-glucopyranoside: acetylated flavonoid glycoside from scoparia dulcis
apigenin 7-O-alpha-L-3-O-acetylrhamnopyranosyl-(1-6)-beta-D-glucopyranoside: acetylated flavonoid glycoside from scoparia dulcis
apigenin 7-O-alpha-L-rhamnopyranosyl-(1-4)-O-alpha-L-rhamnopyranoside: from asplenium normale in malaysia
apigenin 7-O-alpha-L-rhamnopyranosyl-(1-4)-O-alpha-L-rhamnopyranoside-4'-O-alpha-L-rhamnopyranoside: from asplenium normale in malaysia
apigenin dimethylether: a dimethoxy analog of apigenin from roots of rhus undulata and possibly other plants
apigenin-4'-O-(2' '-O-p-coumaroyl)-beta-D-glucopyranoside: an apigenin-derived xanthine oxidase inhibitor from palhinhaea cernua
apigenin-6,8-di-C-glycopyranoside: a potential anti-inflammatory constituent of urtica circularis
apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside: an insulin secretagogue and insulin mimetic isolated from averrhoa carambola
apigenin-6-C-arabinosylglucoside: flavonol glycoside from the seeds of vaccaria segetalis
apigenin-6-C-beta-L-fucopyranoside: from averrhoa carambola
apigenin-6-C-glucosylglucoside: flavonol glycoside from the seeds of vaccaria segetalis
apigenin-7-O-(3'',6''-di-p-coumaroyl)galactopyranoside: isolated from lagopsis supina
apigenin-7-O-(6''-(E)-p-coumaroyl)-beta-D-galactopyranoside: from cirsium setosum
apigenin-7-O-(6''-O-4-coumaroyl)-beta-glucopyranoside: from chinese folk medicine populus tomentosa carr; used for treatment of arthritis
apigenin-7-O-(6''-O-galloyl)-beta-D-glucopyranoside: antiviral from euphorbia humifusa wild
apigenin-7-O-(6''-butyryl-beta-glucopyranoside): isolated from the methanolic extract of the leaves of phyllanthus emblica l.
apigenin-7-O-(6''-p-coumaroyl)galactopyranoside: isolated from lagopsis supina
apigenin-7-O-beta-D-apiofuranosyl (1-2)-beta-D-glucopyranoside: antiviral from euphorbia humifusa wild
apigenin-7-O-beta-D-lutinoside: antiviral from euphorbia humifusa wild
apigenin-7-O-beta-d-(-6''-p-coumaroyl)-glucopyranoside: derived from clematis tangutica; activates ampk signaling and has cardioprotective properties
apigenin-7-O-beta-neohesperidoside: from marrubium deserti de noé
apigenin-7-O-glucuronide: from the leaves and flowers of the cannabinoid-free cannabis (cannabis sativa subsp. sativa l., cannabaceae)
apigenin-7-O-rhamnosyl-1-6-glucoside: an antioxidant isolated from torenia fournieri
apigenin-7-methylglucuronide: isolated from cynara cardunculus l. ( asteraceae)
apigenin-8-C-alpha-rhamnosyl-(1-2)-beta-4-O-methylglucopyranoside: c-glycosylflavone from piper ossanum
apigenin-8-C-beta-D-(2''-O-alpha-L-rhamnosyl)-glucopyranoside: from leaves of bambusa
apigenin-8-C-beta-D-glucopyranoside: from the endophytic colletotrichum sp. of ginkgo biloba
apiin synthetase: transfers d-apiose from udpapiose to 4',5-dihydroxyflavon-7-yl beta-d-glucopyranoside
apilacum: crude drug prepared from secretions of allotrophic gland of bees used in treatment of nutritional disorders, lactaction disorders, puerperal hemorrhage, hypotension, menopausal hypertension, arteriosclerosis, angina pectoris & seborrhea
apitegromab: monoclonal antibody that binds to human promyostatin and latent myostatin
aplasmomycin: from streptomyces griseus isolated from shallow sea sediment in sagami bay; natural ionophore; rn give refers to na salt
aplaviroc: a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the ccr5 receptor with concomitantly potent antiviral effects for hiv-1
aplexone: an antiangiogenic agent and hmg-coa reductase inhibitor
aplicyanin A: isolated from the ascidian aplidium cyaneum, has antiproliferative activity
aplicyanin B: isolated from the ascidian aplidium cyaneum, has antiproliferative activity
aplicyanin E: isolated from the ascidian aplidium cyaneum, has antiproliferative activity
aplidiopsamine A: an antiplasmodial alkaloid from the australian ascidian, aplidiopsis confluata
aplindore fumarate: a high affinity selective dopamine d2 receptor partial agonist
aplycalcin protein, Aplysia californica: member of the calmodulin superfamily of small calcium-binding proteins, genbank u61222
aplyronine A: depolymerizes actin; potent antitumor cpd from the sea hare aplysia kurodai
aplysamine 7: bromotyrosine alkaloid from the australian sponge pseudoceratina verrucosa
aplysianin E: isolated from supernatant of eggs of sea hare, aplysia kurodai; mw: 250 kd
aplysianin P: isolated from purple fluid of the sea hare, aplysia kurodai; induces tumor lysis; rn given refers to cpd with unknown mf
aplysillin A: isolated from the marine sponge; aplysina fistularis fulva
aplysin: antineoplastic agents, alkylating, derived from laurencia tristicha
aplysinamisine I: ; isolated from the caribbean sponge aplysina cauliformis
aplysinamisine II: ; isolated from the caribbean sponge aplysina cauliformis
aplysinamisine III: ; isolated from the caribbean sponge aplysina cauliformis
aplysinoplide A: isolated from the marine sponge aplysinopsis digitata; exhibited cytotoxic activity against p388 mouse leukemia cells
aplysinoplide B: isolated from the marine sponge aplysinopsis digitata; exhibited cytotoxic activity against p388 mouse leukemia cells
aplysinoplide C: isolated from the marine sponge aplysinopsis digitata; exhibited cytotoxic activity against p388 mouse leukemia cells
aplysioviolin: purple pigment isolated from the ink secretion of aplysia californica
apo B48 receptor: a macrophage receptor for apolipoprotein b48; amino acid
apo E-apo A-II complex: a complex of apolipoprotein e and apolipoprotein a-ii
apo-8'-lycopenal: lycopene metabolite with antimetastatic activity
apo-9'-fucoxanthinone: from a gorgonian coral pinnigorgia
apo-dystrophin 1: there are two promoters in the distal half of the duchenne muscular dystrophy gene that produce apo-dystrophin-1 (dp71) and apo-dystrophin-2 (dp116); refseq nm_007868 (mouse)
apoB 4372-4392, human: an effective inhibitor of lp(a) assembly
apoE antagonist 6KApoEp: composed of the ldl receptor-binding domain of apoe (aa 133-152, apoep) or apoep with 6 lysines (6kapoep) added at the n-terminus
apoHDL-sepharose: apohdl bound to sepharose; immobilizes phosphatidyl cholines
apobec-1 complementation factor, mouse: rna-binding subunit of core enzyme involved in c-to-u editing; has been sequenced
apocarotenal oxygenase, Synechocystis: catalyzes the formation of retinal
apohemanthamine: rn given for (3alpha,5alpha,11r,13beta,19alpha)-isomer
apolipophorin III: mw 17,000; from hemolymph of adult manduca sexta (tobacco hornworm); non-glycosylated polypeptide lacking cysteine & tryptophan; associates with lipophorin
apolipoprotein A-I Baltimore: a variant of apolipoprotein a-i; arginine at position 10 is replaced by leucine
apolipoprotein A-I Giessen: a variant of apolipoprotein a-i; proline (p) at position 143 is replaced by arginine (r); it is defective in activating lecithin-cholesterol acyltransferase
apolipoprotein A-I Helsinki: a variant of apo-a-i with a lys(107) deletion mutation; associated with reduced hdl cholesterol and lpa-i:a-ii (lipoprotein with both apoa-i and apoa-ii) deficiency
apolipoprotein A-I Milano: variant of apo-a-i characterized for a cys for arg substitution at position 173 of the amino acid sequence; causes abnormalities in the hdl fraction, high triglycerides & increased postprandial lipemia
apolipoprotein A-I Paris: variant of apo a-i characterized for a cys for arg substitution at position 173 and 151 leading to the formation of homodimers and heterodimers with apo a-ii; has been sequenced
apolipoprotein A-I Tangier: apolipoprotein a-i and isoforms found in patients with tangier disease
apolipoprotein A-I Zaragoza: a variant of apo-a-i found in spanish patients in zaragoza; the apoa1 gene mutation resulted in the substitution of an arg in place of the wild-type leu, at position 144 of the mature protein
apolipoprotein A-I Zavalla: a variant of apo-a-i; leucine (l) at residue 159 is replaced by proline (p)
apolipoprotein A-I mimetic peptide 4F: a synthetic peptide that enhances paraoxonase-1 activity
apolipoprotein A-II isoproteins, human: isoproteins of human apo a-ii, consisting of 76 to 77 amino acids
apolipoprotein A1, Lys(136)-: genetic variant; glu replaced by lys at position 136
apolipoprotein B 38.7, human: truncated form of apolipoprotein b expressed in patient with homozygous hypobetalipoproteinemia associated with diabetes mellitus
apolipoprotein B,E receptor: capable of binding apo b-ldl & apo e-hdl lipoproteins; from hepatic membrane of dog, swine & man
apolipoprotein B-27.6: the smallest truncated apo b identified in plasma; lipid-associated; originally identified in a patient with homozygous hypobetalipoproteinemia
apolipoprotein B-32: has been sequenced; a new truncated mutant of human apolipoprotein b from an individual with heterozygous hypolipoproteinemia; result of single point mutation (1450 gln to stop) in the apo b gene
apolipoprotein B-37: mw 203,000; associated with familial hypobetalipoproteinemia
apolipoprotein B-46: formed by a single nucleotide substitution in the apolipoprotein gene
apolipoprotein B-53: produced intracellularly in hela cell lines but secreted efficiently only from hlm-40 cells
apolipoprotein C-II (Padova): a cysteine (c) to alanine (a) substitution at position 3002 in the apoc2 gene resulting in a premature stop codon for tyr (residue 37); as apolipoprotein c-ii deficiency in an italian kindred
apolipoprotein C-II (St Michael): a nonfunctional variant of apo c-ii, identified at the st. michaels hospital, toronto; substitution at residue 70, glutamine (q) replaced by proline (p), consistent with a base insertion in the codon for asp69 or gln70 in the apoc2 gene and a subsequent translation reading frame shift; associated with premature ischemic vascular disease
apolipoprotein C-II (Toronto): a nonfunctional human mutant apoc-ii identified in toronto; involves a nucleotide deletion in the codon for either thr68 or asp69 and a translation reading frame shift; caused apoc-ii deficiency
apolipoprotein C-II (Wakayama): abnormal apolipoprotein c-ii; trp replaced by arg at position 26; cause of apo c-ii deficiency in this japanese kindred
apolipoprotein E (Arg61), mouse: an apolipoprotein e expressed in hypomorphic apoe mice; is an apoe4-like variant of mouse apoe; expressed at reduced levels in all tissues; the plasma levels are 2% to 5% of normal
apolipoprotein E-rich HDL: cholesterol-induced high-density lipoprotein containing only e apoprotein
apolipoprotein E1: a minor variant isoform of apolipoprotein e; a comparison with major isoform apoe3, showed exchanges at residues 127 and 158 (asp for gly and cys for arg, respectively) in apoe1
apolipoprotein E1 (Harrisburg): a variant of apolipoprotein e1; dominantly associated with type iii hyperlipoproteinemia
apolipoprotein E1 Baden: a new apolipoprotein e variant with (arg(180) to cys) mutation
apolipoprotein E2 (Bethesda): a variant of apolipoprotein e2 isoform; derived from a mutation of the e2 or e2* allele; associated with type iii hyperlipoproteinemia
apolipoprotein E2 (Kyoto): a variant of apolipoprotein e2 isoform; in which arginine at position 25 is replaced by cysteine (arg25-cys)
apolipoprotein E2 (Lys146 -- Gln): a variant of apolipoprotein e2; with glutamine substitution for lysine at position 146; associated with type iii hyperlipoproteinemia
apolipoprotein E3 (Kochi): a variant of apolipoprotein e3 isoform; in which arginine at position 145 is replaced by histidine (arg145-his); associated with hyperlipoproteinemia
apolipoprotein E3 (Leidein): abnormal apo e3; does not contain cysteine residues; defective in binding to ldl receptor; expresses type iii hyperlipoproteinemia
apolipoprotein E4 (Freiburg): a variant of apolipoprotein e4 isoform, with leu replaced by pro at position 28; associated with the coronary artery disease
apolipoprotein E4 (Philadelphia): a variant of apolipoprotein e4, with glutamic acid at 13 replaced by lysine and arginine at 145 replaced by cysteine (glu13lys, arg145cys); associated with severe type iii hyperlipoproteinemia
apolipoprotein E5: a minor isoform of apolipoprotein e; differs from major isoform apo e3 in that the glutamic acid at 3 position is replaced by lysine
apolipoprotein E7, human: a variant of apoe3 in humans; with two lysine residues replacing glutamic acid at positions 244 and 245 (glu244-lys, glu245-lys) and defective binding to low density lipoprotein (ldl) receptors; associated with hyperlipidemia and atherosclerosis
apolipoprotein F: may be identical to leukemia virus-inactivating factor; minor apolipoprotein from sera; apo f & ltip are identical
apolipoprotein II: estrogen-induced destabilization of apoii protein mrna takes place in avian liver
apolipoprotein N-acyltransferase: from e. coli; catalyzes the conversion of apolipoprotein to mature lipoprotein
apolipoprotein R: amino acid sequence given in first source for 23 kda protein from pig; found in vldl and on chylomicrons; member of the short consensus repeat family of proteins
apolipoprotein SAS(SAM): apoprotein consisting of high density lipoproteins which cross-reacts with antiserum against murine senile amyloid fibril protein
apolipoprotein VLDL II: major apoprotein in avian very low density lipoproteins
apolipoprotein b-17: a recombinant, truncated apolipoprotein b
apolipoprotein(a) Kringle IV37: from human liver; amino acid sequence has been determined
apolizumab: a humanized monoclonal antibody against a polymorphic epitope on hla-dr beta-chains
apolpp protein, Drosophila: member of proapolipophorin gene family; refseq nm_079895
apomab: a pro-apoptotic monoclonal antibody agonist against d5-related apoptosis; has been in phase 1 safety trials
apomucin: deglycosylated mucin containing less than 1% carbohydrate; contains 9 different amino acids; mw 96.5kda
aponin: extracted from cultures of the blue-green alga gomphosphaeria aponina; has deleterious effect on the ichthyotoxicity of g. breve-organism responsible for the red tide
aponitrite reductase: translocated to the periplasm of paracoccus denitrificans in the absence of heme incorporation
apopolysialoglycoprotein, rainbow trout eggs: amino acid sequence given in first source
apopolysialoglycoprotein, salmonid fish eggs: amino acid sequence given in first source; rn given refers to amino acid for salvelinus leucomaenis pluvius
apoptolidin: an apoptosis inducer in transformed cells from nocardiopsis sp.
apoptosis protein inhibitor, porcine: a family of anti-apoptotic proteins; genbank u79142
apoptosis-induced regulator protein: a patented protein derived from a 3564 bp cdna from okadaic acid-treated jurkat cells; genbank ax538681, ax538682, and ac538684
apoptotic nuclease Mr 34,000: 34 kda mg2+-dependent endonuclease from hl-60 cells; introduces single- and double-strand breaks into sv40 dna terminating in 3'-oh ends characteristic of apoptosis
apotirucallane: from simarouba amara (simaroubaceae)
appA protein, E coli: bifunctional enzyme with both phytase and acid phosphatase activity; n-terminal amino acid ; do not confuse with appa protein from rhodobacter sphaeroides
appican: chondroitin sulfate (cs) proteoglycan form of the amyloid precursor protein, expressed in human & rat brain; may play a role in the development of alzheimer's disease neuropathology
applanatumin A: dimeric meroterpenoid from ganoderma applanatum with antifibrotic activity
apple polyphenol extract: from unripe apples; contains about 40% condensed tannin, 20% chlorogenic acid, 7% procyanidin b2, 6% catechin, 4% phloridzin, 3% caffeic acid, 3% procyanidin b1, 1% p-coumaric acid, 1% phloretin, 0.5% (+)- catechinhas; has anti-hepatoma activities
aprII protein, Alteromonas: amino acid sequence shows high homology with those of other class ii subtilases; from alteromonas sp. strain o-7; 621 amino acid residues, mw 64 kda; amino acid sequence given in first source
apramide A: from a species of marine cyanobacterium belonging to the genus symploca that was collected in guam
apramide B: from a species of marine cyanobacterium belonging to the genus symploca that was collected in guam