Title: Zeus Home Trial - Study of transcutaneous electrical stimulation in obstructive sleep apnoea using the ZeusOSA device.
Funder: Department of Health and Social Care

Abstract: The world's most common sleep problem is called Obstructive Sleep Apnoea (OSA) and almost 1 billion people in the world have it. Older people and people with weight problems have OSA more often. It can last a lifetime and can negatively affect their health. People with OSA have more chance of having heart problems, strokes and feeling sleepy during the day. They may also die at a younger age. OSA happens while you sleep. When you sleep the muscles in your throat, which is the tube that goes to your lungs, relax causing the throat to narrow. If it gets too narrow you can stop breathing for a short time. Your brain starts you breathing again but you get less oxygen in your blood. Oxygen is important to how your body works. There are machines to help OSA called CPAP. CPAP stands for Continuous Positive Airway Pressure. The machine pumps air through a tube into a mask which fits over your face, pushing air into the throat to keep it open. Wearing the mask can be uncomfortable and you must wear it all night. As it is difficult to wear less than half the people who have CPAP machines use them every night. Morgan has worked with Kings College London and Guys & St Thomas Hospital to make a more comfortable device called ZeusOSA which can help people with OSA. It uses electrical pulses to keep the muscles in the throat firm keeping the throat open, and you breathing normally as you sleep. The device is small and silent and fits under your chin. Morgan has been helped by people with OSA and doctors to make ZeusOSA. ZeusOSA will be cheaper than a CPAP machine, and as more comfortable, people with OSA will wear it more, helping people to stay healthy. MIAT needs to show ZeusOSA works as well, or better than a CPAP machine. Doctors from Dorset County Hospital (DCH) are going to ask 50 people with OSA to try ZeusOSA. We will measure their breathing while they sleep, see if they stopped breathing when they were asleep and will do a questionnaire every morning about how they slept and how they feel. They will be given two ZeusOSA devices to try for 1 week each. One device works and one does not. This helps MIAT prove that ZeusOSA works and it s not just chance. They will also wear other equipment to measure their sleep before the trial, halfway through and at the end. The results will be studied by the doctors and scientists to work out if ZeusOSA does help people who suffer from OSA. A report will be written up and put on MIAT and DCH websites.

Lay abstract: The world's most common sleep problem is called Obstructive Sleep Apnoea (OSA) and almost 1 billion people in the world have it. Older people and people with weight problems have OSA more often. It can last a lifetime and can negatively affect their health. People with OSA have more chance of having heart problems, strokes and feeling sleepy during the day. They may also die at a younger age. OSA happens while you sleep. When you sleep the muscles in your throat, which is the tube that goes to your lungs, relax causing the throat to narrow. If it gets too narrow you can stop breathing for a short time. Your brain starts you breathing again but you get less oxygen in your blood. Oxygen is important to how your body works. There are machines to help OSA called CPAP. CPAP stands for Continuous Positive Airway Pressure. The machine pumps air through a tube into a mask which fits over your face, pushing air into the throat to keep it open. Wearing the mask can be uncomfortable and you must wear it all night. As it is difficult to wear less than half the people who have CPAP machines use them every night. Morgan has worked with Kings College London and Guys & St Thomas Hospital to make a more comfortable device called ZeusOSA which can help people with OSA. It uses electrical pulses to keep the muscles in the throat firm keeping the throat open, and you breathing normally as you sleep. The device is small and silent and fits under your chin. Morgan has been helped by people with OSA and doctors to make ZeusOSA. ZeusOSA will be cheaper than a CPAP machine, and as more comfortable, people with OSA will wear it more, helping people to stay healthy. MIAT needs to show ZeusOSA works as well, or better than a CPAP machine. Doctors from Dorset County Hospital (DCH) are going to ask 50 people with OSA to try ZeusOSA. We will measure their breathing while they sleep, see if they stopped breathing when they were asleep and will do a questionnaire every morning about how they slept and how they feel. They will be given two ZeusOSA devices to try for 1 week each. One device works and one does not. This helps MIAT prove that ZeusOSA works and it s not just chance. They will also wear other equipment to measure their sleep before the trial, halfway through and at the end. The results will be studied by the doctors and scientists to work out if ZeusOSA does help people who suffer from OSA. A report will be written up and put on MIAT and DCH websites.

Research activity codes: 6.3 MEDICAL DEVICES
Health categories: RESPIRATORY