NIHRDataInsights/HRCSData huggingface dataset:
Title: 2012 Cochrane Fellowship- Leeanne O'Hara- Video Intereaction Guidance for Improving Parental Sensitivity
Funder: Health and Social Care Research and Development Division (HSC R&D) of Public Health Agency, Northern Ireland

Abstract: Parental, particularly mothers’ sensitivity, to the behaviour and emotions of their infants is important for the development of secure attachment (Prior and Glasser, 2006), which in turn predicts a less stressful transition to day care and better socio-economic adjustment in later childhood, adolescence and adulthood. Because the attachment relationship is crucial to a child’s physical and mental health and emotional development, there is considerable interest in identifying interventions that can facilitate this, or help address problems in at risk groups (Early Years Framework,2008). A number of interventions are used to improve the sensitivity of mothers to their infants (Bakermans-Kranenburg et al, 2003;2005) including : video interaction guidance (VIG); parent-infant psychotherapy; parenting programmes (e.g. STEEP, Steps towards effective enjoyable parenting); social support and health led services (e.g. Healthy Child Programme). Most are targeted at mothers of infants, though the majority of referrals regarding disrupted parent-child relationships occur between infancy and early school age, when children have ‘adjusted’ to maternal insensitivity in ways that make intervention more challenging (Moss et al., 2001). This review will synthesise the evidence from randomised and quasi-randomised trials of the effectiveness of interventions using VIG to enhance parental sensitivity. Participants: carers of children aged 0-5 years with, or at risk for, problematic attachment. Interventions: any intervention, delivered in any setting by any professional/lay person, designed to improve maternal/parental sensitivity by means of modelling (video feedback), education (discussion of feedback/information giving), the development of empathy (understanding the world from the child’s perspective) and skills development (modelling, shaping, reinforcing sensitive parenting). Comparisons: no intervention or treatment as usual. Outcomes primary: infant mental health using recognised diagnostic classification systems such as DSM-IV-TR; maternal sensitivity; adverse effects. Secondary outcomes: maltreatment ; cognitive and motor abilities and infant social-economic (these last 3 can indicate the onset of infant mental health problems).


Research activity codes: 3.1 PRIMARY PREVENTION INTERVENTIONS TO MODIFY BEHAVIOURS OR PROMOTE WELL-BEING;6.6 PSYCHOLOGICAL AND BEHAVIOURAL
Health categories: MENTAL HEALTH
Title: 2012 Cochrane Fellowship- Aisling McLaughlin- Preventive interventions for improving resilience in children of problem drinkers
Funder: Health and Social Care Research and Development Division (HSC R&D) of Public Health Agency, Northern Ireland

Abstract: Approximately 40,000 children in Northern Ireland are living with parental alcohol misuse (DHSSPS, 2008) and 335,000 children in the UK are living with a dependent drug user (Manning et al., 2009). The effects of ‘Hidden Harm’ on children are wide-ranging and, depending on a child’s age, can include the development of alcohol and drug problems (Corte & Becherer, 2007); depression, anxiety disorders, attachment-related disorder (Velleman & Templeton, 2007); early sexual debut (Chandy et al., 1994); relationship difficulties later in life (Kelley et al., 2010); academic underachievement (Torvik et al., 2011; Sher, 1991) and conduct and behavioural problems (Zucker et al., 1996). Recently, there has been a shift from focusing on how family members can engage and support the substance user through treatment, to adopting a wider holistic focus which considers the needs of family members in their own right (Templeton et al., 2010). This review will synthesise evidence from randomised and quasi-randomised trials of the effects of psychosocial intervention on outcomes for children of parents with substance use problems Participants will be children up to 18 years of age whose parents have substance use problems based on DSM criteria, but including diagnosis by clinicians, parental self-report (e.g. AUDIT, DAST) or child reports (e.g. CAST). Interventions will include cognitive-behavioural interventions, counselling, family focused therapy & psycho-education. Interventions may be of any duration, intensity, or frequency, and delivered in any setting in a variety of ways (e.g. web-based, by a facilitator, delivered individually/in groups, by phone). Comparisons will be no-intervention or management/treatment as usual. Outcome domains will include: i) mental health (primary outcome) (self-esteem, depression, anxiety, psychological adjustment); ii) relationships & support (attachments, relationship satisfaction, social support, social competence, social & coping skills); iii) risky behaviour (substance use, sexual behaviour), iv) educational outcomes (academic achievement) [secondary outcomes, ii-iv].


Research activity codes: 3.1 PRIMARY PREVENTION INTERVENTIONS TO MODIFY BEHAVIOURS OR PROMOTE WELL-BEING
Health categories: MENTAL HEALTH
Title: 2013 Cochrane Fellowship- Antidepressant and antipsychotic medications for children with autism spectrum disorder
Funder: Health and Social Care Research and Development Division (HSC R&D) of Public Health Agency, Northern Ireland

Abstract: Autism spectrum disorder (ASD) is characterised by an impairment in social interaction, an impairment in communication, and restricted or repetitive patterns of behaviours (APA, 2000). Although there is no cure for ASD, some of the behaviours can be reduced through pharmacological interventions, including antidepressants and antipsychotics (Posey 2001). Previous meta-analyses have been conducted on individual examples of each type of pharmacological intervention (e.g. Hurwitz et al., 2012; Jesner et al., 2010), providing useful, high quality information regarding each individual drug’s effectiveness and safety relative to a placebo, waitlist or no treatment. However, no systematic multiple-treatment meta-analysis has been conducted to systematically explore the effectiveness and safety of each drug relative to one other. A network meta-analysis will estimate the relative effects of all the different types of pharmacological interventions, by combining direct and indirect comparisons. Such a review may also be of greater use to clinicians and policy makers, by presenting all the relevant information together in one review and comparing all the different options in relation to one another. This review will synthesise evidence from randomised and quasi randomised trials assessing the effectiveness of antidepressant and antipsychotic medications for reducing the severity of the core symptoms of children with ASD. Participants will include children aged 0 to 18 years with a clinical diagnosis of ASD according to DSM-IV or ICD-10 criteria. Interventions will include any antidepressant or antipsychotic medication, regardless of dosage, duration, and frequency of administration. Studies making direct comparisons of any two or more of these relevant interventions (e.g., SSRI versus haloperidol) will be of primary interest. We will also seek to make indirect comparisons, by combining studies comparing relevant interventions to either placebo treatment, waitlist, or no treatment conditions. Outcomes will include, core features of ASD, aggression, emotional regulation, and attention difficulties.


Research activity codes: 6.1 PHARMACEUTICALS
Health categories: MENTAL HEALTH
Title: Making employment services for people with mental ill-health responsive to need; what are the features of the individual, the work environment and the welfare system that affect the employment of people with mental ill-health.
Funder: Department of Health (England)

Abstract: This research will identify the features of the individual, the work environment and the welfare system that affect the employment of people with mental ill-health in the UK. It will use qualitative interviews to explore factors that make work difficult or that help people stay in or return to work. Analysis of two large national surveys will then identify whether these factors are associated with return to work or loss of work and identify particular groups at risk. The research will be used to develop more responsive mental health services in collaboration with service users, providers and commissioners and make recommendations to influence welfare and health policy.


Research activity codes: 7.1 INDIVIDUAL CARE NEEDS;8.3 POLICY, ETHICS AND RESEARCH GOVERNANCE
Health categories: MENTAL HEALTH
Title: Mediators, Moderators, Mixtures and Model Averaging
Funder: Department of Health (England)

Abstract: Understanding the mechanisms of action of psychological treatments is important. Cognitive behavioural therapy (CBT) is used to treat chronic fatigue syndrome and other diseases. Theoretical models of the pathways through which treatments affect outcomes have been postulated for CBT and other treatments. Using secondary analysis of randomised controlled psychotherapeutic trials, methods for evaluating these potential causal pathways will be applied and further developed. Trials require large resource investments from researchers and the public. Using trial data to understand psychotherapeutic mechanisms in addition to treatment effects maximises the information obtained and informs current practice and future research.


Research activity codes: 1.4 METHODOLOGIES AND MEASUREMENTS
Health categories: MENTAL HEALTH
Title: A simple computerised task ('Tetris') to reduce the build-up of flashbacks after a psychological trauma.
Funder: Department of Health (England)

Abstract: Flashbacks are haunting, distressing memories after psychological trauma. Flashback formation can be impeded using a visual computer task in the laboratory. My objective is to test whether this computer task (‘Tetris’) can reduce flashbacks after real-world trauma. Patients waiting in hospital after a road traffic accident will be randomly assigned to one of two conditions (Tetris/no task). I predict that those given Tetris will develop fewer flashbacks. Parallel laboratory experiments will test underlying memory mechanisms We have no evidence-based interventions immediately after psychological trauma. Findings will provide the first clinical test of a simple new psychological preventative intervention.


Research activity codes: 6.6 PSYCHOLOGICAL AND BEHAVIOURAL;6.3 MEDICAL DEVICES
Health categories: MENTAL HEALTH
Title: Developing and Evaluating an Online Psychoeducational Intervention for Siblings of Individuals with First Episode Psychosis
Funder: Department of Health (England)

Abstract: Siblings of individuals with first episode psychosis (FEP) are both a vulnerable group to develop mental ill health due to the negative impact caused by the psychosis within the family, as well as being the most effective and natural agents to promote service users’ recovery. This study aims to develop and evaluate an online multi-component psychoeducational intervention for this commonly overlooked group of resources and family members. The intervention aims to enhance siblings’ knowledge about psychosis and their coping capacity, thus reducing their vulnerability to mental ill health as well as improving their contribution to the service users’ recovery. The intervention content and delivery formats will be designed as informed by evidence in the literature as well as the siblings’ inputs through consultations and an expert advisory group. Mixed methods incorporated within the MRC phased research design for complex interventions will be used to develop and undertake a preliminary evaluation of the intervention. Qualitative data collection methods such as focus groups and semi-structured individual interviews with siblings will be employed in conjunction with a factorial design randomised trial with several outcome measures to test the effectiveness, feasibility and acceptability of the newly developed intervention with the target population.


Research activity codes: 6.6 PSYCHOLOGICAL AND BEHAVIOURAL;5.6 PSYCHOLOGICAL AND BEHAVIOURAL
Health categories: MENTAL HEALTH
Title: Services for childhood conduct disorder in high need families: A longitudinal, mixed methods investigation.
Funder: Department of Health (England)

Abstract: The proposed research study uses a longitudinal mixed methods design to investigate the changing service use of high need families with one or more children with a conduct disorder. Using interviews with a sample of families and secondary analysis of similar families from longitudinal data sets it looks at what services families receive, what they and practitioners think about the services; what associations are found between receipt of particular kinds of services and outcomes for children, and the likely long-term cost implications of particular approaches. Economic models will be developed using data from the different study strands.


Research activity codes: 3.1 PRIMARY PREVENTION INTERVENTIONS TO MODIFY BEHAVIOURS OR PROMOTE WELL-BEING;8.2 HEALTH AND WELFARE ECONOMICS
Health categories: MENTAL HEALTH
Title: What are Effective Methods to Recruit Research Participants into Mental Health Trials?
Funder: Department of Health (England)

Abstract: “There is a clear need for evidence-based recruitment strategies to enable clinical trials to recruit to target. Adopting the MRC Complex Interventions Framework, we aim to develop an effective recruitment strategy for clinical trials in mental health by; a) surveying and reviewing the existing evidence; b) interviewing stakeholders and observing recruitment in existing trials; and c) testing the new recruitment strategy in an exploratory trial nested in ongoing clinical trials in mental health. The project is linked with: • MRC START (Systematic Techniques for Assisting Recruitment to Trials) (http://www.medicine.manchester.ac.uk/mrcstart/). • Patient Perspectives Theme, MRC North West Hub for Trials Methodology Research (http://www.liv.ac.uk/nwhtmr/).


Research activity codes: 8.4 RESEARCH DESIGN AND METHODOLOGIES (HEALTH SERVICES)
Health categories: MENTAL HEALTH
Title: Identifying the elements of effective hospital management of self-harm: Instrumental variable and meta-regression approaches.
Funder: Department of Health (England)

Abstract: A quarter of all patients who die by suicide are seen in hospital following self-harm in the year before their death. Hospital presenting self-harm thus represents a key opportunity for suicide prevention. Despite this, there is considerable uncertainty about how best to assess, manage and treat self-harm patients to reduce their risk of repetition; existing evidence may be unreliable and few clinical trials have been conducted in this area. Statistical techniques new to this area of research will be used to overcome limitations of previous research and clarify important components in the clinical care of self-harm.


Research activity codes: 6.6 PSYCHOLOGICAL AND BEHAVIOURAL;7.3 MANAGEMENT AND DECISION MAKING
Health categories: MENTAL HEALTH
Title: Core Belief (Schema) Focused Cognitive Therapy for Schizophrenia
Funder: Department of Health (England)

Abstract: Negative beliefs about self and others (“schema”) have been found to be associated with the distress of psychotic experiences such as hearing voices others cannot (hallucinations) and having distressing unusual beliefs (delusions). This is a programme of research to develop a targeted form of cognitive behavioural therapy for schizophrenia, using qualitative approaches, a diary study and a case series of therapy. Findings will inform future controlled trials. It is predicted (hypothesised) that in improving negative beliefs about the self and others, the intervention will lead to improvements in service user outcomes and reduced distressing experiences/symptoms


Research activity codes: 5.6 PSYCHOLOGICAL AND BEHAVIOURAL
Health categories: MENTAL HEALTH
Title: Service use and unmet mental health need in children and young adults: analysis of three years of follow up from the 2004 Child Mental Health Survey and description of primary care psychotropic prescribing and transition in young adults with Attention Deficit Hyperactivity Disorder.
Funder: Department of Health (England)

Abstract: The theme of this research is service use and unmet mental health need amongst children and young adults. The primary objectives are to analyse service use and mental health difficulties over three years in a cohort of school-age children, and to describe primary care mental health prescribing and experiences of transition from child to adult services in young adults with Attention Deficit Hyperactivity Disorder. The research will involve analysis of datasets from the 2004 Child Mental Health Survey and the Clinical Practice Research Database as well as data collection, and will lead to recommendations for improving training and service provision.


Research activity codes: 7.1 INDIVIDUAL CARE NEEDS
Health categories: MENTAL HEALTH
Title: Development of acceptable, feasible and best evidence based course content for training programmes in de-escalation techniques
Funder: Department of Health (England)

Abstract: This project will develop course content for training of mental health staff in techniques to de-escalate potentially violent behaviour. The main aim is to improve the effectiveness of existing training. Data will be gathered through literature review, qualitative interviews with staff, users and carers and training staff. Synthesis of this data will provide a comprehensive list of barriers and facilitators to the effectiveness of training programmes. This will provide the basis for developing an intervention which will be tested to investigate whether regulating the content and duration of training in de-escalation techniques may reduce assaults on NHS mental health staff.


Research activity codes: 7.3 MANAGEMENT AND DECISION MAKING
Health categories: MENTAL HEALTH
Title: The metrics of person-centred care for older people: developing a new care quality measure for community mental health and social care services in later life.
Funder: Department of Health (England)

Abstract: Person-centred care is a central component of any high quality health or social care service. However, for older people with mental health problems in particular, `person-centredness' is difficult to define which causes problems in setting service goals and improving quality. This study aims to develop a new quality measure, focused on person-centred care, for use in community mental health and social care services for older people. Following a literature review and conceptual exercise, a new self-completed questionnaire will be developed, tested and reviewed. A final toolkit will be available to health and social care services nationally.


Research activity codes: 7.1 INDIVIDUAL CARE NEEDS;8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: MENTAL HEALTH
Title: Estimating treatment effects from observational self-harm data in England: the use of propensity score modelling to measure associations between clinical management in general hospitals and patient outcomes
Funder: Department of Health (England)

Abstract: The aim is to use two large observational databases of self-harm attendances to general hospitals in England to investigate the relationship between how patients are managed in hospital and future risk of self-harm and suicide. Careful selection of patients will allow comparison of those who are similar but receive different treatment in hospital. The method uses certain design elements of a randomised controlled trial, whilst retaining the advantage of large numbers of patients from the observational study. The project will inform hospital-level service provision for self-harm patients and help clinicians decide the best treatment and management following a hospital presentation.


Research activity codes: 6.6 PSYCHOLOGICAL AND BEHAVIOURAL;7.1 INDIVIDUAL CARE NEEDS
Health categories: MENTAL HEALTH
Title: Developing effective interventions to prevent or address the adverse effects of loneliness and isolation on the health of older people
Funder: Department of Health (England)

Abstract: Loneliness and social isolation are common amongst older adults. Lonely and isolated older people are more likely to experience ill-health and early death, but there is uncertainty over how to address this. The work proposed here will inform the design of a complex intervention to prevent or tackle the adverse effects of loneliness and isolation on the health and wellbeing of older people. A review of the literature will clarify the nature and size of the problem and identify at-risk groups. Data will be analysed from two national surveys to investigate the relationship between loneliness, isolation and ill-health over time.


Research activity codes: 3.2 INTERVENTIONS TO ALTER PHYSICAL AND BIOLOGICAL ENVIRONMENTAL RISKS;3.1 PRIMARY PREVENTION INTERVENTIONS TO MODIFY BEHAVIOURS OR PROMOTE WELL-BEING
Health categories: MENTAL HEALTH
Title: Personal Recovery in relation to Personality Disorder - Seeking to understand service user experiences in Community and Forensic settings
Funder: Department of Health (England)

Abstract: Personality disorder represents a common form of mental disorder, particularly within prison settings. Little research has been conducted addressing personal experiences of recovery in personality disorder, which may be very distinct from clinical assumptions made in relation to recovery. Interviews with service users and providers will be used to explore important aspects of personal recovery for those with a personality disorder. Additional interviews within prison settings will seek to identify barriers to recovery experienced by individuals within these environments. An understanding of these experiences of recovery will allow services to provide care that is better tailored to an individual’s preferences.


Research activity codes: 7.1 INDIVIDUAL CARE NEEDS
Health categories: MENTAL HEALTH
Title: Modifiable risk factors for depression in adolescence – understanding the causal role of physical activity and obesity
Funder: Department of Health (England)

Abstract: Approximately 6% of adolescents in the UK suffer from depression. Adolescent depression is a serious problem; it is a risk factor for suicide, has a detrimental effect on quality of life, and sufferers are more likely to experience depression as adults. Obesity and low levels of physical activity are associated with depression, but it is not clear how or which comes first. The aim of this project is to look more closely at this association. This could lead to the development of new prevention strategies and guidance, and reduce the burden associated with adolescent depression to individuals and the NHS.


Research activity codes: 3.1 PRIMARY PREVENTION INTERVENTIONS TO MODIFY BEHAVIOURS OR PROMOTE WELL-BEING;2.1 BIOLOGICAL AND ENDOGENOUS FACTORS
Health categories: MENTAL HEALTH