Title: RCUK Innovation Fellow
Funder: Science and Technology Facilities Council

Abstract: The University of Leicester also has a unique heritage in space instrumentation; every year since 1967 has seen a Leicester-built instrument operating in space. Leicester is particularly well known for its work in X-ray astronomy and planetary science, designing and building detectors of high energy photons for space missions such as XMM-Newton, Beagle 2 and BepiColombo. The detection of high energy photons is also important for aspects of medicine, nuclear power and security, and for characterising materials in sectors like manufacturing, mining, and archaeology. This project aims to build research, innovation and translation programmes based on core STFC funded research through investigating technology designed for detecting high energy photons in space and applying these to terrestrial applications. One key application is medical imaging. A portable gamma camera has been developed at the University of Leicester that has made use of similar technology to that developed for the XMM-Newton EPIC X-ray camera. Medical gamma cameras, which are used for a wide range of medical diagnostic tests including determining whether cancer has spread to other areas of the body, can take up a whole room in a hospital. The portable camera developed at Leicester is small enough to be hand held and so it can be brought to the patient wherever they may be, even in the operating theatre. This could make a big difference to surgeons, who currently perform radioguided surgery with a non-imaging detector, which beeps when detecting radioactivity (similar to a metal detector). The gamma camera can show the position and shape of any radioactive sources, in addition to showing their location on an optical overlay, which should greatly help surgeons in localising sources within the body, reducing surgical trauma and improving patient outcomes. As the detection of high energy photons has a wide array of applications, and the portable gamma camera from Leicester includes unique technology for combining high energy photons invisible to the naked eye along with visible light, there is potential to transfer this to a number of other sectors. Part of the project will entail adapting this platform technology for testing in target environments to determine whether it can be of interest to other industries. Adaptations of the gamma camera have the potential to open up research and commercialisation in a wide number of sectors. The fellow will also be involved in the University of Leicester's research into novel detector materials. Semiconductors (silicon being the most commonly used) are vital components in all sorts of electronics, including detectors. Novel compound semiconductors are varied and many are 'tunable', able to exhibit different properties depending on their chemical makeup. Detectors made from new semiconductor materials may, for example, be far more sensitive to high energy photons than silicon, or may be able to operate at far higher temperatures. This opens up applications in a range of industries, including in nuclear security. The fellow will work with lead players in the UK nuclear security sector to determine gaps in current detector provision where new materials would be useful, and will then work to investigate materials to fill that gap. The fellow will have the full support of the University, which will provide high quality training in a number of key areas related to knowledge transfer and innovation. Sectorial specific training will also be provided by industrial partners. Embedding this experience within the department will accelerate current and future commercialisation projects, and further capitalise on funding provided by the STFC.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.5 RADIOTHERAPY AND OTHER NON-INVASIVE THERAPIES
Health categories: CANCER AND NEOPLASMS