NIHRDataInsights/HRCSData huggingface dataset:
Title: HAITI-POC - High Accuracy Immunoassay Test at Point-of-Care
Funder: Innovate UK

Abstract: Biomarker assays offer robust and accurate diagnosis for some conditions but cannot be performed at the point-of-care, increasing costs to the system and inconvenience for patients. In addition, current technologies are not well-suited to the complex, multi-factor analysis needed by the next generation of assays. Orphidia proposes a ground-breaking technology that brings lab-quality tests to the point-of-care and maintains accuracy for complex tests. Orphidia will transform the process of biomarker development, significantly accelerating the uptake of new assays and increasing profitability and investment in the sector. In this project we will validate the accuracy of tests run on Orphidia's chip, confirm clinical specifications for the product and refine the commercial proposition of the system. Successful delivery will allow us to move forward with completion of the full Orphidia system, in order to enter the market one year after project-end and enable faster, better treatment for patients.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES
Health categories: GENERIC HEALTH RELEVANCE
Title: Microbial Enzymatic Drug Modification to Improve Treatment Outcomes
Funder: Innovate UK

Abstract: The major healthcare imperatives are to deliver effective prevention and treatment of diseases. Whist pharmaceutical intervention of disease progress is effective in many cases, the use of medicines can also lead to adverse reactions resulting in the need for further medical intervention, compounding the cost of therapy. The aim of this project is to further develop a platform product, already used in part by the pharmaceutical industry, to allow the greater exploration of the chemical space of a potential drug to overcome the main cause of adverse reactions, polymorphic variation of cytochrome P450 enzymes (CYPs). Hypha currently uses microbial biotransformations to produce metabolites and effect lead molecule-diversification for Pharma-based clients. The feasibility of a cell-free version of the product will be assessed to target advantages comprising speed of delivery and use in a kit form, enabling Pharma clients to innovatively deliver improved medicines with more predictable properties.


Research activity codes: 5.1 PHARMACEUTICALS
Health categories: GENERIC HEALTH RELEVANCE
Title: A wireless, wearable, automated early warning system for patients in emergency care
Funder: Innovate UK

Abstract: This project aims to design and develop an automated wireless and wearable system for early detection and notification of patient deterioration in the emergency care pathway. This will be achieved by incorporating additional physiological measurements into our existing wireless, ambulatory platform, enabling automated calculation and notification of NICE-recommended National Early Warning Scores (NEWS). This development is highly innovative because there are no systems in current clinical use which automate the detection and notification of patient deterioration via NEWS, while allowing patients to remain comfortable and mobile as they move through the emergency care phase. The output from the project will be a prototype system ready for clinical validation and/or clinical trials in an emergency care setting. This project has the potential to save costs while delivering more effective and timely treatment to emergency care patients.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;4.2 EVALUATION OF MARKERS AND TECHNOLOGIES
Health categories: GENERIC HEALTH RELEVANCE
Title: UbiquiSon - Ubiquitous ultrasound; machines within the reach of every clinician, all the time.
Funder: Innovate UK

Abstract: The UbiquiSon project is about realising the enticing prospect of ubiquitous ultrasound - putting ultrasound within the reach of every clinician, all the time. In essence the goal is to produce low-cost, highly portably devices that are capable of generating the high quality images that clinicians need and desire, with significant benefit in a wide range of clinical settings. Four clinical impacts of ubiquitous ultrasound have been identified: (1) Faster access to ultrasound; (2) Broader access to ultrasound; (3) Reduced clinical risk and (4) Change in clinical behaviour. The expectation is that this will lead to both improved patient care and substantial healthcare efficiency improvements. The cost of these innovative ultrasound machines will be low enough to make their purchases part of discretionary spend. The proprietary SmartUS technology is what makes this leap feasible.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES
Health categories: GENERIC HEALTH RELEVANCE
Title: Service Design Research UK
Funder: Arts and Humanities Research Council

Abstract: Service Design Research UK (Sdr UK) aims to create a UK research network in an emerging field in Design that is Service Design. This field has a recent history and a growing, but still small and dispersed, research community that strongly needs support and visibility to consolidate its knowledge background and enhance its potential impact. Services represent a significant part of the UK economy and can have a transformational role in our society, if we think of how they affect the way we organize, move, work, study or take care of our health and family. Design introduces a more people-centred and creative approach to service innovation, which is critical to delivering more effective and novel solutions that have the potential to tackle contemporary challenges. The UK is a leader in the development of Service Design, mainly driven by design practitioners (Engine, Livework, Thinkpublic, Participle, Snook, etc.) and organizations such as the Design Council, Design Wales, Demos, Young Foundation, NHS Institute for Innovation and Improvement. In this scenario the academic contribution to the development of Service Design as a subject of research and practice has been instead weak and dispersed. This network aims to: 1. Identify, compare and map current research work into Service Design in UK; 2. Increase understanding of and demand for Service Design as a practice and research field in UK; 3. Identify research and knowledge gaps in the field to inform PhD studies and future research projects collaborations and ideas; 4. Increase visibility and connectivity of Sdr UK nationally and internationally. The research network will create the opportunities, for the Sdr UK's emerging research community, to converge around three main themes: 1) Service Design for Innovation; 2) Service Design for Social Good; 3) Service Design for Sustainability. Three thematic workshops will bring together academics, designers, public and private sector organizations and relevant institutions to collect and map the research work done till now, discuss project exemplars, share experiences and identify research gaps and future research themes. The workshops outcomes will be made available on a dedicated on-line platform, where the emerged research questions will be used to inform an on-line forum. Sdr website will be linked with existing national and international initiatives and on-line communities related to the topics of service research and innovation. The international Service Design and Innovation (ServdDes) conference to be held at Lancaster University in April 2014, will host a final public event to present Sdr UK results and to organize discussion tables around the emerged research themes to springboard possible future research collaborations.


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: Culture Change for Health Care Green Space Engagement
Funder: Arts and Humanities Research Council

Abstract: The proposed work builds on a project that aimed to encourage greater use of hospital grounds for health and well-being benefit. It will utilise materials produced within the project such as workshop frameworks, an engagement toolkit and greenspace intervention evaluation guidance to disseminate knolwedge to health services managers, clinical staff, other health care workers, environmental sector professionals and voluntary sector agencies about how to get staff, visitors and patients using healthcare buildings' grounds and adjacent 'public' greensapce for health and well-being benefit. The main activities will be: (i) Combined dissemination and training workshops for health service managers and clinical staff. (ii) Cross-sector (health, environment, public and voluntary) networking and exchange events. Each of these activities will be held at three sites within the NHS Forth Valley region; one in NHS Highalnd and an additional two sites in other Scottish health board areas. We will hold workshops at which NHS staff, environmental sector staff and voluntary sector staff can learn about the knowledge and materials generated in our original project. The workshops will involve training in tools and methods for encouraging greenspace use through participatory planning; leading conservation and other outdoor activities; and monitoring and measuring the benefits of outdoor activities. As a result of the workshops, the stakeholders will devise a plan for activities and small changes that could be made at their healthcare settings (e.g. healthcare centres) to encourage people to use the outdoors for health and well-being benefit. These plans will outline the roles that stakeholders such as the NHS, Forestry Commission, Local Authority and local voluntary sector will play in the future development of greenspace activities. Taking part in the workshops will equip stakeholders with the tools needed to plan and deliver greenspace activities at various types of healthcare setting. This work will help build relationships between the health, environment and community sectors for the management and use of outdoor spaces associated with, or adjacent to, healthcare buildings. The work aims to bring health and well-being benefits to staff, patients and community members through their increased use of such spaces.


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: Communities within spaces of flows
Funder: Arts and Humanities Research Council

Abstract: The Communities within Spaces of Flows project is situated in a period of public sector spending cuts in which services are stretched and there has been a government call for a return to localism to address well-being needs (Localism Act, 2011; The Scottish Government, 2009). This idealistic desire to involve people in local decision making and community empowerment is at odds with the evolving concept of community where the place related connectivity of traditional communities has been replaced by more dispersed social networks maintained by technology and new mobility patterns. The networks of interpersonal ties that provide sociability, support, a sense of belonging and social identity are now less likely to reside in place and are less able to react to local need. At the same time there is growing recognition of the importance of integrating digital technology and health (Tinder Foundation, 2011) and a need to find new mechanisms to support an ageing population with increasing accessibility needs (Musselwhite & Haddad, 2010). The Connectivity and Conflict in Periods of Austerity project has illustrated how those with access to network capital (i.e. the resources, such as cars and mobile technology, needed to sustain and generate social capital) are best placed to exert influence on their localities while others remain excluded. This provides the grounding for this follow-up project with its revelations about middle class political activism and its effects on public services while other groups are marginalised. This poses fundamental questions about public engagement and people's ability to take control of their own well-being. This application for follow-up funding therefore explores important questions about technological interventions and their role in community well-being, fostering responsibility for place and local connectivity. The project will reflect on the fit of a combination of AHRC Connected Communities funded technologies, in addition to a collaborative travel App developed by the Sixth Sense Transport project (EPSRC Digital Economy funding, EP/J004650/1) (Davies et al. 2012), to extend and enable place based community support networks to obtain health and well-being gains. The project builds on the previous good working relationship with Wester Hailes and considers how the work of the Connected Communities groups might complement the more traditional patient/GP relationship and help produce measurable improvements in health.


Research activity codes: 1.2 PSYCHOLOGICAL AND SOCIOECONOMIC PROCESSES
Health categories: GENERIC HEALTH RELEVANCE
Title: A Development project to determine and progress the 'state of the Art' of Design theory and Practice in healthcare
Funder: Arts and Humanities Research Council

Abstract: We welcome the AHRC's identification of Design as a strategic priority. The Art and Design research centre at Sheffield Hallam University has a rich tradition of design research and practice spanning over 20 years. Over the last 5 years this expertise has been brought to bear on the complex and hitherto untapped potential of design in Health and social care. This critical mass of work has been centred around two specific collaborations within the research centre. Firstly Lab4Living, which is a partnership between researchers in health and design, between practitioners and designers and, most importantly between individuals who use products and services and the designers of these (www.lab4living.org.uk). Secondly the National Institute of Health Research (NIHR) funded User-centred Healthcare Design (UCHD). UCHD is another multidisciplinary project specifically exploring the use of design theory and practice in healthcare (www.uchd.org.uk). These collaborations have resulted in the International Design4Health conference being held in 2011 and 2013 (http://www.design4health.org.uk/) This conference and associated activities have provided an excellent focus for the discussion around the translation of design research into healthcare and have linked business, university and third sectors around a bewildering array of projects. The conversations around the key challenges for this area of design have started in this forum, but the AHRC funding would allow a literature review and a series of seminars to explore the key themes identified at the close of the last conference, namely: Languages of evaluation across design and health projects How to articulate Design's unique contribution to the field of healthcare innovation The range of modes of engagement with health care that designers can have The first stage of the proposed project would be to commission a comprehensive literature review to determine the range and amount of activity already underway in the UK and internationally in design for health. This would provide a sound evidence base for the second phase of the work. The conference steering committee already has excellent representation from across the UK design academic landscape, who alongside those with experience of Healthcare and Health research, would be able to start to frame and then answer the questions, and ground the answers in the practical experience of delivering projects. The latter part of the project will translate the outputs of the literature review and workshops into an engaging digital form of dissemination All of these activities will have a natural outlet in the Design4Health conference 2015.


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: A Critical Review of the Effectiveness of the Therapeutic Use of Artistic Activity
Funder: Arts and Humanities Research Council

Abstract: Within the body of research on arts and healthcare, there have been attempts at measuring and valuing the effects of the arts on clinical outcomes although often this is context specific (e.g. for specific amenities or initiatives/programmes in specific locations) and lacking a policy purpose. Despite this, the role and value of the arts in healthcare continues to be recognised and carry weight in policy terms Although there is also evidence of silos of knowledge, and critics point out that there is a split between individualised notions of maintaining health and a more socially determined appreciation of the impacts of health inequalities and social interactions on everyone. Both arts and health operate across both sides of this divide but rarely are seen in this dual context. We propose to conduct a multi-dimensional critical review of the effectiveness of art therapy for the patient, published in academic journal articles and articles written for a healthcare audience (e.g. practitioner, healthcare manager/provider or policy), that has the stated goal of providing evidence of therapeutic benefit from an artistic activity through measurement of a health state. We will follow the processes used within public health for conducting a critical review of literature on a body of mixed research-study designs. This will involve setting out pre-determined criteria for literature to be included in the study; double reading all the papers and classifying the literature by study design, health state, stated therapeutic mechanism; expert assessment of possible therapeutic mechanism; and finally providing a narrative summary of the findings based on the quality of evidence and the volume of available evidence. The approach we will adopt for reviewing the literature will enable the current state of knowledge about the value of arts and culture in clinical and therapeutic contexts to be consolidated in relation to the overall quality of evidence. By adopting a recognised public health process to review and synthesise a large body of low-quality evidence we are using the current body of research to best advantage rather than simply criticising the quality. This will provide a holistic and, up to date, picture of the state of knowledge in the area of arts and therapeutic and clinical interventions, which is robust and transparent. In addition we will provide new ways of classifying the techniques which move beyond the simple classifications based on the form of the media (eg, music based or fibre art based therapies).


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: Data-driven quality improvement in primary care using informatics to implement new prescribing quality measures integrated with educational interventions and existing quality inprovement mechanisms
Funder: Chief Scientist Office (Scotland)

Abstract: The research programme will design and test a comprehensive intervention to improve the safety and quality of prescribing in general practice. We have shown in pilot work that new types of prescribing measure can identify significant numbers of patients with clear opportunities for safer or better prescribing. We will use evidence-based methods to prompt practices to review these patients to improve their care. These include educating GPs and nurses about when patients taking particular combinations of drugs should be reviewed, helping practices identify who these patients are, and motivating them to act on the information through education, feedback of how their quality of care compares to other practices, and possibly financial incentives to take part in quality improvement. We will carefully design the intervention working with doctors, nurses and patients, and test whether or not it is effective in a clinical trial. This will be done in a series of six linked studies over five years, and we will work with patient representatives to make sure that we keep patient perspectives to the fore. We will design the intervention in such a way that it can be easily used in any Scottish Health Board. The main intended outcome is better and safer prescribing for patients. Additionally, we will explore whether this kind of work improves collaboration between practices and Health Boards, and what patients think about the use of their clinical data in this kind of quality improvement work.


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: CCP4: Low resolution complexes handling difficult data; empowering structural biologists and supporting UK structural biology
Funder: Biotechnology and Biological Sciences Research Council

Abstract: 1.RA Post 1. Low resolution structures present special problems. Template-matching methods developed by Dr Cowtan provide a proven basis for the interpretation of maps of limited quality, and these methods will be enhanced by the use of larger scale structural information; this approach will be applied to model building and refinement at lower resolutions. 2. RA Post 2. Integrating intensities from diffraction images represents a crucial and fundamental step in the structure determination process, as all subsequent steps are dependent on these measurements and their estimated standard uncertainties. New data processing algorithms will be developed to handle multiple lattices, to automate processing and data analysis and to deal with the new Pilatus detectors. 3. RA Post 3. A database back-end will be developed to systematise and store all the data relevant to structure solution. We will design sensible 'wizards' to improve the consistency and accelerate the rate of structure determination, based on systematic handling of this information. 4. RA Post 4. Finally, for these tools to have the maximum benefit they will be translated into robust well-supported software distributed to the community. Software produced by tasks 1-3, by other CCP4 supported projects, and by independent contributors will be integrated into the suite in a way that is intuitive for a non-specialist. These major tasks will be complemented by suite-wide changes that keep CCP4 relevant to the latest challenges, such as large complexes


Research activity codes: 1.4 METHODOLOGIES AND MEASUREMENTS;1.5 RESOURCES AND INFRASTRUCTURE (UNDERPINNING)
Health categories: GENERIC HEALTH RELEVANCE