NIHRDataInsights/HRCSData huggingface dataset:
Title: Liverpool Clinical PhD programme for Health Priorities in the Global South
Funder: Wellcome Trust

Abstract: This programme will deliver high quality, bespoke doctoral training for 20 clinical scientists across multiple scientific disciplines to address health priorities in the Global South. Through careful selection, high quality supervision and training, and access to excellent facilities in both the UK and globally, we will develop a cohort of trainees highly skilled at implementing research in Low and Middle Income Countries (LMICs). Building on 13 years of successful PhD programme delivery for medical doctors and, more recently, veterinarians, we will broaden the programme to include clinical specialties for which we have established supervisory capacity and research excellence. We will provide new avenues in Global Health training opportunities for midwifes, with expansion to other clinical professions as demand and support develops. The programme will be supported by strong doctoral training frameworks in place at University of Liverpool & Liverpool School of Tropical Medicine. Equality, diversity and inclusivity will be embedded at all points of the programme consistent with the practice of the two institutions. Success will be measured by progression of fellows into academic positions and Fellowships during and after completion of clinical training and their subsequent emergence as independent research leaders addressing health priorities in LMICs.


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UK Biobank
Funder: Wellcome Trust

Abstract: As summarised in the extracted text below from our full application (page 5 "Proposed work") in Section 10 of this application form (and described in more detail on pages 5-16 of Section 10). During the next 5 years, it is intended to: • Extend cohort-wide linkage to primary care health records, while maintaining and updating health outcome data from existing linkages to death, cancer and hospital records (and explore the added value of linkages to additional healthcare datasets); • Further develop and implement large-scale identification and characterization of many different types of health outcome; • Streamline the research access systems, and improve methods for processing, presenting and providing linked healthcare data to researchers; • Maintain the sample resource, and make increasing amounts of different types of genotype and biomarker data available; • Conduct imaging assessments in 100,000 participants, and develop and implement further enhancements (such as cardiac monitoring and further sample collection and assays). Efforts will continue to be made to ensure that researchers from around the world are suitably well informed about the resource so that the effective use of it increases substantially, leading to novel findings that have a major impact on human health.

Lay abstract: No Data Entered

Research activity codes: 1.5 RESOURCES AND INFRASTRUCTURE (UNDERPINNING)
Health categories: GENERIC HEALTH RELEVANCE
Title: Ensembl: A Comprehensive Reference Resource for Genomics
Funder: Wellcome Trust

Abstract: Ensembl is the world’s most comprehensive genome informatics resource. We have powered genomic analyses for over twenty years through our data, know-how, software and deep ties to the research community. Today, as genomic medicine is scaling up across the world and the effects of the sixth mass extinction become increasingly apparent, genomics has a critical role to play in addressing key societal challenges. To meet these challenges and stay relevant in a fast paced environment, we are preparing for landmark innovations in our processes, including (i) a transition to the graph-based human reference genome; (ii) an increased use of cutting-edge technologies including machine learning to more accurately annotate genomes; (iii) an expansion of the number of supported genomes from hundreds to tens of thousands; (iv) an extensive redevelopment of our comparative genomics infrastructure; (v) a complete overhaul of our release cycle to release data as quickly as we can annotate it; (vi) the launch of our new website; and (vii) the release of new APIs that will replace our Perl API for external users. Keywords: genome annotation, bioinformatics, database, biodiversity, functional interpretation of genetic variation, model organisms, genome regulation, agricultural genomics, FAIR data, open source software, open and reproducible science.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY)
Health categories: GENERIC HEALTH RELEVANCE
Title: Academy of Medical Sciences: Breaking Boundaries
Funder: Wellcome Trust

Abstract: The Academy of Medical Sciences’ mission is to advance biomedical and health research and its translation into benefits for society. The vision set out in this proposal is central to our strategy to create a diverse workforce of researchers to advance scientific discovery and to generate and optimise improvements in health. Drawing on our strengths of breadth, connectivity and unparalleled career support activities, over the next five years we will: 1. Support researchers’ transition to independence by enhancing our Starter Grants for Clinical Lecturers and Springboard for Biomedical Researchers schemes 2. Promote health innovation with new programmes that support greater cross-disciplinary and pan-sector connectivity and collaboration by researchers This proposal will enable us deliver a platform of cohesive, innovative activities that enhance research career pathways and achieve wider positive impacts on diversity and research culture. Our proven track record in galvanising action across the sector and leveraging further funding will drive greater coordination and effort across the UK’s university, healthcare and industry sectors.In five years’ time we will have created mechanisms and a regional infrastructure that will equip and support cohorts of excellent researchers and future leaders to work collaboratively and proactively in addressing societal health challenges.


Research activity codes: 1.5 RESOURCES AND INFRASTRUCTURE (UNDERPINNING)
Health categories: GENERIC HEALTH RELEVANCE
Title: UK Biobank: Provision of a managed informatics platform for accessing the UK Biobank resource and supporting research analyses
Funder: Wellcome Trust

Abstract: UK Biobank is an international resource with 500,000 richly phenotyped participants offering non-preferential access to bona fide researchers seeking to understand the determinants of disease. With investments being made by industry, government and charity, the resource is increasingly detailed and is already the most genetically characterised resource in the world. With anticipated inclusion of whole exome and whole genome sequence data, this will remain the case for many years to come. Together with imaging, cardiac monitoring, activity and metabolomics measures, the resource will comprise over 15 Petabytes of health-related data by 2025. These increasingly large and complex datasets mean it is no longer tenable for researchers to download data and requires new platform access methods to allow researchers to generate the scientific discoveries of the next decade. Funding is sought to implement an informatics platform to allow access and analysis of UK Biobank data in-situ in conformance with access policies and security controls. The platform will further democratise access, ensuring researchers around the world can participate on the same, non-preferential basis with appropriate support. Funding will cover implementation and management for a period of 5 years after which the platform will become financially self-sustaining through access charges.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY)
Health categories: GENERIC HEALTH RELEVANCE
Title: The Living Roots Project: Building a community asset and research consortium in Ealing, West London to address health equity
Funder: Arts and Humanities Research Council

Abstract: This grant will support the scoping and formation of a 'community asset and research partnership' to build a 'living roots bridge' that brings together and explores community and public health linkages within the North West London (NWL) Integrated Care System (ICS) to tackle health inequity. Ealing is a 'superdiverse' borough in West London with racially minoritised and migrant communities, longstanding histories of mobilising for racial justice, and rich cultural and community assets. These assets include local parks, allotments, youth centres, a vibrant music scene, art galleries, and food hubs, to name a few. Here, there are vast inequities in health between groups linked to intersecting social determinants of health, including ethnicity, wealth and income. Focusing on Ealing and through a 'syndemics' framework and participatory action research, we will (1) create shared understandings of the main problems related to health (in)equity and potential areas for change, (2) map and scope community assets and facilitate collaboration, and (3) explore collaborative models with a view to establishing one (or more) community asset and research hubs with linkages to the NWL ICS. A 'syndemics' approach enables us to view health problems as interconnected, specifically looking at the social context which drives multiple health problems in disadvantaged populations. This is more robust than 'single disease' approaches which often dominate public health thinking. We will use transdisciplinary, inclusive approaches which critically, seek to build trust amongst partners, and with the aim of facilitating long-term collaboration through a sustainable, engaged research consortium for systems change, health equity and wellbeing in Ealing. We envision that this project will benefit the wider Ealing community through 1) focusing on an 'assets' or strengths-based approach, which includes a better understanding of wellbeing, and 2) bringing together diverse, and also under-represented, voices to take action on health equity in the borough.


Research activity codes: 2.3 PSYCHOLOGICAL, SOCIAL AND ECONOMIC FACTORS;7.1 INDIVIDUAL CARE NEEDS
Health categories: GENERIC HEALTH RELEVANCE
Title: Downloading a new normal - privacy, exclusion, and information behaviour in public library digital services use during COVID
Funder: Arts and Humanities Research Council

Abstract: The necessity to switch from analogue to digital in so much day-to-day living has been the overarching experience of the COVID lockdown for many of the UK population. This project explores "the digital turn" and how compelled use of digital services during COVID lockdown and beyond has impacted one specific sector, namely public libraries across the UK. In doing so it considers issues that have been faced in other public and private organisations across society because of the lockdown, such as (1)privacy and ethical issues in the utilisation of digital in the spaces that were previously overtly analogue in nature, (2)linked issues of digital exclusion and ensuring equity of access, and (3)how information behaviours have adapted and/or been impacted across age groups and other societal demographics. The example of the borrowing of a book brings home the issues; this universally-understood activity of visiting a library building, browsing shelves, and leaving with a physical book has been replaced with (1)visiting library website (2)downloading an app (3)logging into a third party vendor's service (4)agreeing their privacy policy, and (5)navigating their interface to download your content. This is a significant departure from the traditional experience, and raises important issues around privacy, digital equity, and information behaviour that we need to understand. By utilising FoI queries, readability and content analysis of library websites and 3rd party privacy policies, a nationwide survey of library users, and eight UK-wide focus groups, we will gain important insights into how compelled use of digital has impacted society.


Research activity codes: 3.2 INTERVENTIONS TO ALTER PHYSICAL AND BIOLOGICAL ENVIRONMENTAL RISKS
Health categories: GENERIC HEALTH RELEVANCE
Title: Imagining Posthuman Care
Funder: Arts and Humanities Research Council

Abstract: According to the Office for National Statistics, the U.K. has an ageing population. Statisticians predict that "more than a quarter of UK residents will be aged 65 years or over within the next 50 years." Demographers have devised the "dependency ratio" to quantify the difference between (potential) dependents aged 65 and older and working-age members of the population. Demographic predictions suggesting the ratio will rise significantly between 2014 and 2039 alert us to the potential for a care deficit, a significant gap between demand and availability of dependency workers. Caregiving robots, are poised to fill this gap and there is significant public apprehension about the prospect of nonhumans, particularly robots, taking over traditionally human caregiving roles. Titles of recent U.K. newspaper articles -- "A robot carer? No thanks - we still need the human touch" (The Guardian), "Love them or leave them, robot carers are still inhuman" (The Times), and "'Care-bots' for the elderly are dangerous, warns artificial intelligence professor" (The Telegraph) -- provide evidence of this apprehension. Nonhuman caregivers challenge existing models of care that view companionship as distinctly, or even exclusively human. The impending proliferation of a wide variety of caregiving robots complicates the association between "humane" care and the human. This Fellowship examines how representations of human/robot relationships can help us imagine and interpret the ethical, political, and philosophical implications of nonhuman care. How humans regard, use, and relate to care robots is highly dependent on the look, feel and sound of these machines, and how these sensual elements invoke cultural traditions, concepts, and sentiments regarding technology, care, and the nonhuman. Similarly, preexisting cultural and social ideas and feelings can play a significant role in the creation of care robots. This Fellowship considers imaginary robot companions depicted in literature, film and television in order to understand how such representations of nonhuman care reflect, and are reflected by the definitions, ethics, politics, and economics of care. The project stems from a belief that exploring the nuances of robot representation can assist in the development of a posthuman vision of care, that is, an ethic of care that accounts for the complexity of how humans and machines relate.


Research activity codes: 5.3 MEDICAL DEVICES;7.1 INDIVIDUAL CARE NEEDS;8.3 POLICY, ETHICS AND RESEARCH GOVERNANCE
Health categories: GENERIC HEALTH RELEVANCE
Title: Clinical Intelligent Automation of Preventative Care
Funder: Innovate UK

Abstract: In addition to _treating_ disease, healthcare staff in primary care try to _prevent_ disease. Patients who meet clinical risk criteria can benefit from actions like starting medications before they develop a disease. These _preventative interventions_ reduce the risk of disease or delay it. **40% of all yearly deaths are thought to be due to preventable causes**\[1\]**,** signifying the immense potential to improve life span and quality of life. Prevention is the most cost-effective approach compared to the costs and burden on the healthcare system of managing and treating established disease. Clear guidelines are made available by institutions like the National Institute for Health and Care Excellence (NICE). **Delivering prevention is simple and inexpensive -- finding which patients, need which intervention, at what time is a huge and expensive task**. For example, approximately 800,000 out of 18 million patients who meet initial criteria for risk assessment\[2\] would benefit from bisphosphonates, an affordable, easily available drug that strengthens bones and reduces the risk of hip fractures -- a disabling, costly condition. Finding these individuals at risk is currently a complex, repetitive and manual task that involves asking the right patients the right questions and processing this information through complex clinical guidelines. This task is the responsibility of General Practices who are also responsible for managing existing disease and struggling with workload and staffing issues made worse by the COVID pandemic. Current digital solutions only support fragments of this process such as running searches or sending text messages making automation impossible and still requiring multiple touchpoints from clinicians. As a result, coverage is poor -- for example, only 8.2% of patients who fractured their hip were on protective medications\[3\]. This is just one of 33 primary care guidelines promoted by NICE on prevention\[4\] which could be delivered more effectively, uniformly and efficiently. The grant will fund a health-tech company, as well as GPs, a Clinical Commissioning Group, and experts in measuring economic benefits and clinical safety, will deliver the platform to 250,000 patients over the next two years. This project will deliver a software that will continuously find patients who might benefit from interventions that prevent hip fractures, heart attacks and strokes. It will automatically contact those patients to collect specific information required to identify those who need preventative treatment. The evidence collected will allow the Clinical Intelligent Automation platform to be delivered throughout the UK and internationally within 5 years.


Research activity codes: 3.5 RESOURCES AND INFRASTRUCTURE (PREVENTION);8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: An innovative electronic preoperative assessment solution using GP data and ML/AI models that could reduce nursing time required per patient by 40%
Funder: Innovate UK

Abstract: Aire Logic Limited is a UK digital health SME with a core project team of Michael Odling-Smee, Alwyn Kotzee, Kevin Maguire and Cairen Ball. AireLogic is developing a solution that enables preoperative assessments to incorporate GP records and improve their efficiency. Hospitals currently conduct preoperative assessments manually, relying on patient s' own knowledge of their medical history, costing £99M/year. Improving this process is crucial to addressing NHS England's waiting list, which now stands at 5.98M people. The solution enables a range of interactions between patients and assessors and supports preassessment through automation and data transformation, enabling nurses to spend their time more productively.


Research activity codes: 8.1 ORGANISATION AND DELIVERY OF SERVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: Tento+ Regulatory Management Tool
Funder: Innovate UK

Abstract: For over 40 years, AND Technology Research have been developing bespoke electronics/software products and prototypes for the medical device market , and have been advising customers on regularity requirements worldwide. Through previous work and market analysis, there exists a clear need to tackle the overbearing costs and barriers for innovators. They are often confused by regulation and moreover, the journey to achieve certification. Tento+ enables innovators to understand, track and progress the regulatory pathways required for medical devices. Initially targeting UKCA and EU CE, future developments are planned for other markets. It provides a simple, easy to use dashboard where innovators can detail their medical devices, track progression to certification, access advise, be signed posted to resources and utilise AI enabled analytics to ease their journey. Through developing Tento+ as a Software-As-A-Service, it will become an the on-stop-shop for innovators to track and manage their end-to-end regulatory journey.


Research activity codes: 5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT)
Health categories: GENERIC HEALTH RELEVANCE
Title: Liquid Brain: Neuromorphic sensing and computing platform for high-throughput screening of antibody developability
Funder: Innovate UK

Abstract: Drug development costs are rising and pharmaceutical R&D efficiency is falling, increasing costs for BioTech and Pharma companies, healthcare providers, and reducing affordability and accessibility for patients worldwide. 90% of drug candidates fail during clinical-stage development. Poor developability accounts for one third of clinical-stage failures of biologics, costing approximately USD450M per drug developed. High-throughput screening technologies deployed in the critical hit-to-lead phase of drug discovery are used to evaluate thousands of potential drugs against the drug target. Yet, comprehensive assessment of key biophysical properties associated with drug developability remains severely restricted by resource and time constraints, including limited material availability, particularly for biologics. Apoha is a stealth-stage start-up (UK SME), founded in 2021 by Dr Shamit Shrivastava (inventor of Apoha's core platform technology; ex-postdoctoral researcher, University of Oxford) and Anshika Srivastava (ex-Executive Director/Vice President, Goldman Sachs). Our mission is to create a new paradigm for sensing and computing that is powerful and sustainable at scale, inspired by the physics of brain matter. We are developing a "liquid brain", a neuromorphic fluid-based technology that mimics neuron-like activity when it is exposed to a chemical. The fundamental science behind our innovation was highlighted by Scientific American in 2018 as a "Revolution in Science that could change everything". With Innovate UK support, we will apply our "liquid brain" platform technology to the challenge of poor antibody developability, by developing a neuromorphic sensing and computing platform for high-throughput screening of underlying biophysical properties. We will combine our proprietary and patented hardware with cutting-edge neuromorphic algorithms trained to rank antibodies based on their developability potential. Our innovation directly addresses a key barrier to global transformative research highlighted in the UK Innovation Strategy 2021, that of declining pharmaceutical R&D efficiency and the rising cost of drug development.


Research activity codes: 5.1 PHARMACEUTICALS
Health categories: GENERIC HEALTH RELEVANCE
Title: Aston University and Alpharmaxim Limited KTP 21_22 R2
Funder: Innovate UK

Abstract: To apply the latest Behavioural Psychology research to develop a validated tool (H-BIT) that will identify beliefs and barriers in prescribing behaviour of EU healthcare professionals in specific disease areas, to enable targeted communication strategies that maximise the reach of treatments.


Research activity codes: 7.1 INDIVIDUAL CARE NEEDS;7.3 MANAGEMENT AND DECISION MAKING
Health categories: GENERIC HEALTH RELEVANCE