Title: NIHR HPRU on Chemical and Radiation Threats and Hazards at Imperial College London
Funder: Department of Health and Social Care

Abstract: Through this HPRU we will address today s most pressing chemical and radiation hazards and threats, advance understanding of how the everyday and exceptional contact we have with chemicals and radiation leads to ill health and deliver timely impact on policy to improve the long-term health of the nation. This HPRU is led by Imperial College London in partnership with Public Health England, King s College London and MRC Toxicology Unit, Cambridge. Our four research themes integrate basic science, molecular and cell biology and large-scale population studies. Theme 1 - Radiation will improve understanding of the health impact of exposures to natural and man-made sources of radiation, including cancer risks near nuclear installations, from using telecommunications (mobile phones and police radios) and the role of ionising radiation and ultraviolet light in cardiovascular disease. Theme 2 - Biomarkers will enhance understanding of how chemical and radiation exposures cause disease by studying molecules found in blood or urine (biomarkers) that tell us about contact with specific agents. We will study biomarkers of ionising radiation used in healthcare (e.g. CT scans), common man-made chemicals (e.g. flame retardants, organophosphates, persistent organic pollutants) and chemical exposures near landfill sites. Theme 3 - Linking in vitro testing to real-world data will deliver new knowledge on how chemicals damage cells (human or the micro-organisms that live within us) to cause disease. We will apply this learning in two real-world settings: reproductive health near landfill sites and long-term health among workers exposed to radiation. Theme 4 - Neurotoxins and high toxicity agents will investigate novel highly toxic chemicals, how best to protect people from the effects of these agents (including decontamination after contact) and how to remove them from the environment. This will include study of household mould, chemicals in drinking water and chemical warfare agents. We will embed Public and community involvement and engagement (PCI/E) at the centre of the HPRU, incorporating the public voice in all stages of the research cycle and co-designing our PCI/E strategy and activities. Our Knowledge and Mobilisation activities will deliver timely impact on public health policy. Our research will be underpinned by a strong programme of training and capacity development that will create 10 PhD studentships and 3 early career researcher posts. Through close collaboration with the NIHR Academy we will train skilled researchers in priority areas to translate public health research into practice and strengthen the future of health protection research.

Lay abstract: Through this HPRU we will address today s most pressing chemical and radiation hazards and threats, advance understanding of how the everyday and exceptional contact we have with chemicals and radiation leads to ill health and deliver timely impact on policy to improve the long-term health of the nation. This HPRU is led by Imperial College London in partnership with Public Health England, King s College London and MRC Toxicology Unit, Cambridge. Our four research themes integrate basic science, molecular and cell biology and large-scale population studies. Theme 1 - Radiation will improve understanding of the health impact of exposures to natural and man-made sources of radiation, including cancer risks near nuclear installations, from using telecommunications (mobile phones and police radios) and the role of ionising radiation and ultraviolet light in cardiovascular disease. Theme 2 - Biomarkers will enhance understanding of how chemical and radiation exposures cause disease by studying molecules found in blood or urine (biomarkers) that tell us about contact with specific agents. We will study biomarkers of ionising radiation used in healthcare (e.g. CT scans), common man-made chemicals (e.g. flame retardants, organophosphates, persistent organic pollutants) and chemical exposures near landfill sites. Theme 3 - Linking in vitro testing to real-world data will deliver new knowledge on how chemicals damage cells (human or the micro-organisms that live within us) to cause disease. We will apply this learning in two real-world settings: reproductive health near landfill sites and long-term health among workers exposed to radiation. Theme 4 - Neurotoxins and high toxicity agents will investigate novel highly toxic chemicals, how best to protect people from the effects of these agents (including decontamination after contact) and how to remove them from the environment. This will include study of household mould, chemicals in drinking water and chemical warfare agents. We will embed Public and community involvement and engagement (PCI/E) at the centre of the HPRU, incorporating the public voice in all stages of the research cycle and co-designing our PCI/E strategy and activities. Our Knowledge and Mobilisation activities will deliver timely impact on public health policy. Our research will be underpinned by a strong programme of training and capacity development that will create 10 PhD studentships and 3 early career researcher posts. Through close collaboration with the NIHR Academy we will train skilled researchers in priority areas to translate public health research into practice and strengthen the future of health protection research.

Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY);4.5 RESOURCES AND INFRASTRUCTURE (DETECTION)
Health categories: CANCER AND NEOPLASMS;CARDIOVASCULAR