NIHRDataInsights/HRCSData huggingface dataset:
Title: UK Biobank Genetic Analyses Enhancement
Funder: Medical Research Council

Abstract: During the next 2 years, all 500,000 participants in UK Biobank will be genotyped. Dense “biobank” genotyping chips have recently been developed that combine measurement of about 250,000 SNPs in a whole-genome array, about 200,000 markers covering copy number variation, loss of function, insertions and deletions, and previously identified risk factor or disease associations, and about 150,000 exome markers which cover a high proportion of non-synonymous coding variants with allele frequency over 0.02%. These “biobank” genotyping chips provide a powerful tool for enabling genome-wide interrogation of common variants, and a scaffold that allows extension to lower frequency and rarer variants by imputation from reference sequence data sets (e.g. 1000Genomes, UK10K, GoT2D). Availability of these genotype data on the whole UK Biobank cohort would allow inference of haplotype phase at the genotyped SNPs at higher accuracy than is typical with whole-genome association studies (GWAS), using novel methods that exploit haplotype sharing within populations. The exome-focused component would allow exploration of phenotypic effects of a large number of functional coding variants, which would benefit from the data on a wide range of traits that are available on the participants in UK Biobank. Improvements in inference of phase, and the subsequent imputation, would increase the statistical power for associating genetic variants with biomarkers, phenotypes and disease outcomes. These genotyping data would remain of value even when UK Biobank participants start to be sequenced as they can be used to validate the sequencing data and to impute even more detailed genetic information for the whole cohort. Combination of such rich genotyping data with the extensive range of known biochemical risk factors currently being measured (about 50 analytes that are related to cardiovascular disease, cancer, metabolic and renal disease, and other conditions), along with the detailed phenotyping from the baseline assessment visit (which includes information about prevalent disease) and data on the development of disease during follow-up from linkage to health records, will make UK Biobank uniquely rich as a resource for scientists from all areas of health research to conduct genetic association studies rapidly and cost-effectively (since they would only need to request data rather than fund genotyping). Hence, acquisition of dense genotype data in all of the UK Biobank participants will facilitate analyses that harness the full power of the resource.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY)
Health categories: GENERIC HEALTH RELEVANCE
Title: High-throughput Genomics and Transcriptomics of the Human Developmental Biology Resource
Funder: Medical Research Council

Abstract: The Human Developmental Biology Resource (HDBR) is an on-going collection of human fetal material ranging from 3 to 20 weeks of development, jointly funded by the MRC and Wellcome Trust and hosted by Institute of Genetic Medicine, Newcastle University and Institute of Child Health, University College London (http://www.hdbr.org/). Highly specialised human materials including tissues for cell culture, RNAs from sub-organ specific regions, and slides for spatial gene expression studies are available to the international scientific community, and linked studies contribute to a growing atlas of gene expression data throughout early fetal human development. These data are made publicly available on the Human Developmental Studies Network (HuDSeN) website (www.hudsen.org), and have underpinned over 250 projects to date in research groups across the globe. Here we aim to: (i) genetically characterise 450 of the human fetuses in the HDBR using high-density arrays to determine single nucleotide and copy number variants; and, (ii) generate forebrain transcriptome data by RNAseq from a subset of 200 where frozen tissue is available. These data will be made publically available on the HuDSeN website to enable the international research community to: (i) study the impact of the genetic variants on gene expression profiles in the developing brain; and/or (ii) access a range of fetal tissue harbouring a variant in a gene of interest to guide functional studies of a particular gene or pathway. This will provide a unique resource to evaluate genetic data being generated by several MRC resources, and advance our understanding of the developing human brain.


Research activity codes: 1.5 RESOURCES AND INFRASTRUCTURE (UNDERPINNING)
Health categories: GENERIC HEALTH RELEVANCE
Title: Expanding Interdisciplinary Translational Project Infrastructure.
Funder: Medical Research Council

Abstract: Confidence in Concept Award toUniversity of Birmingham. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoBath Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Bath. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoC Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Cambridge. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoCardiff Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to Cardiff University. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoDundee Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to ???????????. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoEdinburgh Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Edinburgh. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoGlasgow Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Glasgow. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: ICL Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to Imperial College London. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: KCL Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to King's College London. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoL Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Leeds. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoLeicester Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Leicester. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoLiverpool Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Liverpool. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: London School of Tropical Medicine Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to Liverpool school of Tropical Medicine. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoManchester Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to The University of Manchester. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY);5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT)
Health categories: GENERIC HEALTH RELEVANCE
Title: UoNewcastle Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to Newcastle University. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoNottingham Confidence in Concept2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Nottingham. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY);5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT)
Health categories: GENERIC HEALTH RELEVANCE
Title: UoOxford Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Oxford. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 6.9 RESOURCES AND INFRASTRUCTURE (TREATMENT EVALUATION);5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT)
Health categories: GENERIC HEALTH RELEVANCE
Title: QMUL Confidence in Concept 2014
Funder: Medical Research Council

Abstract: Confidence in Concept Award to Queen Mary, University of London. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY);5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT);4.5 RESOURCES AND INFRASTRUCTURE (DETECTION)
Health categories: GENERIC HEALTH RELEVANCE
Title: Queens University Belfast Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to Queen's University, Belfast. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UoSheffield Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Sheffield. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 2.6 RESOURCES AND INFRASTRUCTURE (AETIOLOGY);5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT)
Health categories: GENERIC HEALTH RELEVANCE
Title: UoStrathclyde Confidence in Concept2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University of Strathclyde. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: UCL Confidence in Concept 2013
Funder: Medical Research Council

Abstract: Confidence in Concept Award to University College London. The Confidence in Concept scheme provides awards of £300k-£1m to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.


Research activity codes: 4.1 DISCOVERY AND PRECLINICAL TESTING OF MARKERS AND TECHNOLOGIES;5.1 PHARMACEUTICALS;5.2 CELLULAR AND GENE THERAPIES;5.3 MEDICAL DEVICES
Health categories: GENERIC HEALTH RELEVANCE
Title: Modifying a weight management intervention for people with intellectual disabilities
Funder: Medical Research Council

Abstract: Obesity is a major public health concern nationally and internationally. There is a higher prevalence of obesity in adults with intellectual disabilities (ID) compared to the general population (39.3% women; 27.8% men with ID are obese compared with 25.1% women;22.7% men in the general population). Interventions shown to be clinically effective at achieving sustained weight loss in the general population are unlikely to be accessible and appropriate to this population because of their complexity. Research is needed to develop and test weight loss interventions designed to meet the needs of this population (recognising communication and literacy needs as well as broader issues of participation and inclusion). The proposed study is informed by the MRC framework and involves both development and feasibility components. The study will adopt a participatory approach to review and where necessary, modify and existing weigh management intervention (Slimming World), for use with adults (age ≥18) with ID who are overweight or obese (BMI>25). It will explore the feasibility and acceptability of delivering the modified intervention from the perspectives of a range of stakeholders. Only adults with the capacity to consent prior to recruitment. The study will be carried out in collaboration with eight people with ID in recognition of the importance of involving disabled people in the development of services addressing their needs. Outputs from the study will include a prototype of a modified Slimming World (SW) intervention for use with adults with ID who are overweight or obese, a protocol for establishing capacity to consent, a set of measures and procedures for collecting data from participants with ID and briefing notes on the development process to inform similar work on other issues. The study will conclude with an assessment of whether to proceed to a pilot trial made in collaboration with representatives from Sheffield University Clinical Trials Research Unit.


Research activity codes: 3.1 PRIMARY PREVENTION INTERVENTIONS TO MODIFY BEHAVIOURS OR PROMOTE WELL-BEING
Health categories: GENERIC HEALTH RELEVANCE
Title: Evidence synthesis of clinical trials and human genome epidemiology
Funder: Medical Research Council

Abstract: The proposed research programme addresses issues in evidence synthesis, working largely to improve the methods used in systematic reviews undertaken by international organisations such as The Cochrane Collaboration. Parallel streams of work in clinical trials and human genome epidemiology include consideration of meta-analysis methods, advanced evidence syntheses, sequential methods and dealing with biases. Some major areas of work will be (i) generalised synthesis of clinical trials, including multiple treatments and variation in their delivery; (ii) understanding the extent and causes of heterogeneity in clinical trials; (iii) evaluating the properties of genetic tests; (iv) developing sequential methods for meta-analyses of clinical trials and epidemiological studies; (v) developing approaches for assessing potential reporting biases; (vi) major contributions to organisations that undertake and promote systematic reviews, and to the generic methodological guidance they offer.


Research activity codes: 8.4 RESEARCH DESIGN AND METHODOLOGIES (HEALTH SERVICES);2.5 RESEARCH DESIGN AND METHODOLOGIES (AETIOLOGY)
Health categories: GENERIC HEALTH RELEVANCE