Title: NIHR Manchester BRC
Funder: Department of Health and Social Care

Abstract: Manchester has a deep heritage of science, invention and entrepreneurship. We have world-leading strengths in basic science including discovering genes and cellular mechanisms that cause disease, inventing and developing new materials and devices (2010 Nobel Prize for Physics) and computing (e.g. use of big data ). We also have leading strengths in medical sciences with ground-breaking cancer research, discovering how the immune system causes (or controls) disease and understanding how lifestyle and environment may trigger ill-health. Many medical breakthroughs in Manchester have already brought health improvements, nationally and worldwide, including new treatments for cancer and psoriasis as well as newborn deafness screening programmes. The recent Devolution Agreement and One Manchester approach has brought the NHS, public health and local authorities together to form a single Greater Manchester health and social care system with an integrated budget. The Central Manchester NHS Foundation Trust/University of Manchester partnership s Manchester BRC (MBRC) sits at the heart of this revolution and aims to accelerate new discoveries through translational research that will improve health. Links are established with industry, the public and charity partners who are eager to work with us to achieve this vision. MBRC will use P4 Medicine to: Prevent disease; Predict disease progression; Personalise treatment pathways; Empower patients to Participate in their healthcare. We will achieve this by addressing clinical areas which are major causes of premature death and high disability and in which we have highly productive basic science research within the partnership, namely: Musculoskeletal diseases; Hearing health; Respiratory diseases; Skin diseases; Cancer. MBRC will be a dynamic team of researchers working together to drive forward our research plans by learning from each other, sharing ideas, discoveries and methods to provide maximum health benefits in the most cost and time efficient manner. Our new integrated health and social care system provides the ideal proving ground to create compelling evidence of how our research findings can then be applied for health, social and economic benefits across the nation and beyond. The reduction of health inequalities is a priority for us. We believe that all sections of an increasingly diverse society should benefit from our work regardless of ethnic origin, social group, age, gender or economic standing. Disease burden remains disproportionately loaded in socially disadvantaged groups, this is particularly significant in Manchester. We will improve this situation by fully recognising this diversity in the design and execution of our work. MBRC will engage with all sections of the public so that they can shape and participate in our work and encourage patients and carers to be actively involved in managing health. This makes Manchester an ideal environment in which to train future scientists and health-care professionals and the BRC will develop future leaders to allow this work to continue into the future. MBRC will therefore become a world-leading research powerhouse and drive forward research to address major health challenges and transform the prevention, diagnosis and treatment of diseases for the benefit of the population and for wider economic gain.

Lay abstract: Manchester has a deep heritage of science, invention and entrepreneurship. We have world-leading strengths in basic science including discovering genes and cellular mechanisms that cause disease, inventing and developing new materials and devices (2010 Nobel Prize for Physics) and computing (e.g. use of big data ). We also have leading strengths in medical sciences with ground-breaking cancer research, discovering how the immune system causes (or controls) disease and understanding how lifestyle and environment may trigger ill-health. Many medical breakthroughs in Manchester have already brought health improvements, nationally and worldwide, including new treatments for cancer and psoriasis as well as newborn deafness screening programmes. The recent Devolution Agreement and One Manchester approach has brought the NHS, public health and local authorities together to form a single Greater Manchester health and social care system with an integrated budget. The Central Manchester NHS Foundation Trust/University of Manchester partnership s Manchester BRC (MBRC) sits at the heart of this revolution and aims to accelerate new discoveries through translational research that will improve health. Links are established with industry, the public and charity partners who are eager to work with us to achieve this vision. MBRC will use P4 Medicine to: Prevent disease; Predict disease progression; Personalise treatment pathways; Empower patients to Participate in their healthcare. We will achieve this by addressing clinical areas which are major causes of premature death and high disability and in which we have highly productive basic science research within the partnership, namely: Musculoskeletal diseases; Hearing health; Respiratory diseases; Skin diseases; Cancer. MBRC will be a dynamic team of researchers working together to drive forward our research plans by learning from each other, sharing ideas, discoveries and methods to provide maximum health benefits in the most cost and time efficient manner. Our new integrated health and social care system provides the ideal proving ground to create compelling evidence of how our research findings can then be applied for health, social and economic benefits across the nation and beyond. The reduction of health inequalities is a priority for us. We believe that all sections of an increasingly diverse society should benefit from our work regardless of ethnic origin, social group, age, gender or economic standing. Disease burden remains disproportionately loaded in socially disadvantaged groups, this is particularly significant in Manchester. We will improve this situation by fully recognising this diversity in the design and execution of our work. MBRC will engage with all sections of the public so that they can shape and participate in our work and encourage patients and carers to be actively involved in managing health. This makes Manchester an ideal environment in which to train future scientists and health-care professionals and the BRC will develop future leaders to allow this work to continue into the future. MBRC will therefore become a world-leading research powerhouse and drive forward research to address major health challenges and transform the prevention, diagnosis and treatment of diseases for the benefit of the population and for wider economic gain.

Research activity codes: 4.5 RESOURCES AND INFRASTRUCTURE (DETECTION);5.9 RESOURCES AND INFRASTRUCTURE (TREATMENT DEVELOPMENT)
Health categories: MUSCULOSKELETAL