NCube/papyrus huggingface dataset:
La sécrétion de la protéine Tau : nouveau mécanisme de propagation de la pathologie de Tau dans la maladie d'Alzheimer

Tau, a microtubule-associated protein, is enriched in the axon. In Alzheimer’s disease, Tau becomes hyperphosphorylated, redistributes to the somato-dendritic compartment and forms aggregates called neurofibrillary tangles (NFTs). The NFTs propagates in a predictable manner in particular neuronal networks. Indeed, they appear in the trans-entorhinal region and then propagate to the entorhinal cortex where the trans-entorhinal cortex projects. Then, the NFTs propagate to the hippocampus and to different regions of the cortex and neocortex. Recent studies have reported that Tau can be secreted by neuronal cell lines. Besides, when aggregates of Tau protein were injected in mouse brain, they could enter neurons and induced Tau pathology. Based on those observations, it was speculated that Tau could be secreted by neurons and then captured by neighbouring cells to propagate Tau pathology in the brain. The goal of the present study was to prove that Tau can be secreted by neurons and to find the secretory pathway involved in Tau secretion. Moreover, the phosphorylation state of Tau protein was examined and compared to intracellular non-secreted Tau. Our results showed that Tau is secreted by cortical neurons isolated from wild-type mice and by HeLa and PC12 cells overexpressing human Tau. Our results also indicated that autophagosomes would be involved in Tau secretion. Finally, we found that secreted Tau was dephosphorylated and cleaved compared to the non-secreted intracellular Tau.

Keyphrases: Tau, Alzheimer, Phosphorylation, Exosomes, Tauopathies, Secretion
La logique déontique : une application de la logique à l'éthique et au discours juridique

In this essay we aim to provide a critical analysis of the literature regarding deontic logic. First of all, we wish to give a historical account of deontic logic's evolution, which will be done mainly by chapter 2. This chapter concerns the paradoxes of deontic logic and gives an overview of the usual systems and their origin. Our second objective is to provide a synthesis of the literature regarding the formal analysis of the normative discourse. The chapters 3, 4 and 5 give an account of the three principal ways which deal with deontic operators, that is the monadic deontic logic, the dyadic deontic logic and the temporal deontic logic. Finally, we propose a critical analysis of that literature and we show that these systems do not represent adequately some of the normative discourse's fundamental characteristics. We will accomplish this by providing an analysis of the legal discourse and show that the concept of obligation has some properties and behaves in a way that cannot be represented by the actual systems.

Keyphrases: Paradoxes, Deontic logic, Normative discourse, Paradoxes, Modal logic, Standard systems, Semantical analysis of legal discourse, Normative system, Normative inference
Étude exploratoire sur les espaces équivoques, leurs dynamiques d’appropriation et les enjeux urbanistiques à Montréal

This research takes an interest in the equivocal spaces, which means the ambiguous spaces resulting form different forms of spatial appropriation that take place in them. By a heuristic process and with an exploratory two case studies, which use ethnographic research methods, this master thesis aims to characterize the equivocal spaces. The two spaces considered, both situated in the north part of the Plateau-Mont-Royal’s borough in Montreal, are a wasteland informally called Parc sans Nom and an industrial vacant lot informally called Champ des Possibles. With a qualitative approach, the positions of the municipal authorities and of the users of the two sites, in terms of the physical constraints, the coercive measures and the perceptions of risk and potential of conflict in the two spaces, will be analyzed. The results of this analysis allow us to find that the equivocal spaces emerge from a co-construction process. The results allow us also to underline some considerations on the people’s relationship to urban space.

Keyphrases: Co-construction, Public spaces, Private spaces, Appropriation of space, Design, Management, Conflicts, Negociations, Co-construction
Discussions politiques sur Internet : les raisons expliquant le degré de participation de jeunes adultes québécois

This master thesis deals with the reasons some young adult Quebecers have to be or not to be involved in political discussions on the Internet. It was written within the general context of the rise of Web 2.0 and within the specific context of the Canadian elections of May 2011. At the theoretical level, we have worked with German philosopher Jürgen Habermas' Theory of Communicative Action along with his conception of the Public Sphere. From a methodological standpoint, we have studied a sample made up of young adult Quebecers, both men and women, aged between 19 and 30, living in Montreal and its surroundings. These young citizens were questioned throughout four focus group sessions. The collected data was analysed with an argument extraction method in accordance with the rational reconstruction methodology. The results allowed us to expose many reasons that could explain the questioned young adults' level of involvement in online political discussion. These reasons were regrouped in four themes: the lack of knowledge and the public aspect; awareness and feedback; reaction based on content, the nature of the network and the value of information; face-­‐to-­‐face conversation, anonymity and controversial topics. In order to highlight the contributions of this study to the field of communication, the results were discussed while considering those obtained by other researchers. The discussion also allowed us to adopt a critical and theoretical point of view to explore what the results of this thesis reveal on the state of the Public Sphere in Quebec.

Keyphrases: Political discussion, Internet, Internet, Young adult, Public sphere, Montreal
Définition de la pastorale de la Création en tant que nouveau ministère dans l’Église catholique du Québec

This research attempts to define Creation Care so that it is recognized as a ministry in the Catholic Church in Quebec. I followed the method of pastoral praxeology inspired by the humanities so that this practice is both effective in the field and faithful to the Gospel of Jesus Christ. The object of analysis is the practice itself, specifically the parish activities on the theme of the environment. I closely observed some relevant activities, including a training session given to pastoral assistants. Then I interpreted these comments in light of the Christian Tradition by drawing on the Bible, several theological references and Church statements. After this reflection, I improved this practice by organizing a new training for the Church staff, the project of a practical guide and the outline of a course on Creation Care Ministry to be given in universities. Finally, the prospective allowed me to imagine in the long-term how the practice will ensure a sustainable church ... in every sense.

Keyphrases: pastoral, environment, creation, church, ministry, Catholic, Quebec, praxeology
Les cours de danse africaine à Montréal, émergence d’une production socioculturelle et esthétique

This thesis deals with the teaching of African dance in France and in Canada. The research for this thesis began in 2007, when the author took part in a student exchange and ended with a consideration of African dance in Quebec as a consumer good and/or an imaginary sociocultural production. The analysis explores the benefits and the limits of the methodological approach embraced by the anthropologist (who is, in this case, a former dancer with training in classical dance), and the terms of the encounter between Africans and Westerners through dance. While it remains to be shown that the post-modernist critiques of mass art apply to this context, the analysis here points to the presence of a  professional consciousness in African dance lessons in Quebec. Critiques of dance and other arts as democratization tend to get lost in the fear of popular discourse. The main objective of this research is therefore to establish the limits of the fetishism associated with African dance and to discuss in further detail the « hantise du Troisième Homme », communicated by ethnographic research and anthropological analysis

Keyphrases: African dance, Aestheticism, Fetishism, Postmodernism, World culture, Ethnochoreology
Ninon de Lenclos (1623-1705), le parcours d’une libertine au XVIIe siècle

Thanks to the concepts developed by the gender history, this Master's thesis seeks to re-evaluate the life of the seventeenth century libertine courtesan Anne de Lenclos, known as Ninon. The courtesan’s image promoted since the eighteenth century doesn’t reveal the complexity of the character: it only focuses on Ninon’s sexual behaviours or on her intellectual abilities and her role in the literary life of the “Grand Siècle”. A new reading of the courtesan’s correspondence and notarial acts (economical acts, testament, post-mortem inventory) allows us to gain a new understanding of the figure of Ninon. Indeed, our research demonstrates how the courtesan succeeded conciliate transgressions against the established order with an admired and respected “salonnière” reputation.

Keyphrases: Libertinage, Gender History, Libertinism, 17th Century, Sociability, Correspondence
Subepithelial collagen content in the peripheral airways of heaves-affected and control horses

Extracellular matrix remodelling is present in the human asthmatic lung, and is characterized by increased collagen or fibrosis of the subepithelial area of the airway. Heaves, a naturally occurring chronic lower airway inflammatory condition in horses shares aspects of pathophysiology with asthma, including features of airway remodelling. We thus hypothesize that airway fibrosis is a characteristic of remodelling in heaves. The aim of this study was to evaluate the presence of fibrosis in the subepithelial area of the peripheral airways of heaves-affected horses. Peripheral lung biopsies acquired under thoracoscopic guidance were obtained from 5 control and 6 heaves-affected horses, both before (T0) and after a 30 day antigenic challenge with mouldy hay and straw. Prior to the study, diseased horses were in clinical remission and exhibited no clinical signs of disease. Obtained samples were microscopically examined using picrosirius-red, a collagen specific histological staining technique. Collagen area in the subepithelial layer, e.g. the region between the airway smooth muscle and the epithelial layer was measured, and corrected for airway size using standard morphometric techniques. In comparison with controls, heaves-affected horses had an increased collagen content in the airway subepithelial area (p<0.1). No change in fibrosis of the subepithelial area was observed in diseased horses after the 30 day antigenic challenge. Peripheral airway subepithelial collagen at baseline was positively associated with maximal changes in transpulmonary pressure and pulmonary resistance in horses with heaves but not in controls. Results of this study indicate that fibrosis of the subepithelial area is present in the peripheral airways of heaves-affected horses, and may play a role in residual lung function deficits observed in diseased horses even while in clinical remission.

Keyphrases: Heaves, Recurrent airway obstruction, Animal model, Asthma, Horses, Lungs, Fibrosis of the subepithelial area, Remodelling
Régulation des processus de réparation de l’épithélium bronchique sain et Fibrose Kystique par le TNF-alpha

Cystic fibrosis (CF) pathology, caused by mutations of cftr gene, leads to ion and fluid transport dysfunction that results in mucus thickening and accumulation in the airways. This mucus accumulation promotes bacterial infection and airway inflammation associated with progressive airway epithelial damage in CF patients, unfortunately leading to respiratory failure. However, the effect of inflammatory products on the repair capacity of respiratory epithelia is unclear. Thus, the objective of my project was to study the regulation of normal and CF bronchial epithelial repair mechanisms by tumor necrosis factor-alpha (TNF)-alpha, a major component of inflammation initiation and propagation in CF. With a wound healing model, we observed that TNF-alpha stimulated the non-CF (NuLi-1) and CF (CuFi-1) bronchial wound healing rate. Surprisingly, chronic exposure to TNF-alpha enhanced this stimulation as well as the migration rate during repair. This wound healing rate stimulation by TNF-alpha seems to be due to metalloproteinase MMP-9 activation, EGF shedding by epithelial cells and subsequent EGFR transactivation. Furthermore, we recently reported a crucial relationship between the EGF response and K+ channel function, both controlling bronchial repair. We now show that TNF-alpha wound healing stimulation also implicated KvLQT1 and KATP currents activation. In contrast to its effect on cell migration, TNF-alpha downregulate cell proliferation. Thus, in addition to its recognized role in the inflammatory response leading to epithelial injury, TNF-a could exert complex actions on repair mechanisms of CF airway epithelia by upregulating cell migration while downregulating proliferation.

Keyphrases: Inflammation, EGFR, MMP, Airways, Potassium channels
Les pratiques parentales, le désengagement scolaire des amis et le rendement scolaire chez les élèves du secondaire nés en Haïti et fréquentant une école en milieu défavorisé

School underachievement has important consequences, both individual and societal. Haitian adolescents seem particularly at risk of experiencing such academic difficulties. Yet, very few Canadian studies have focused on the academic experience of students in this community. Studies conducted with other minority groups have however reported the important influence of friends and parents in regard to these adolescents’ achievement. The objective of this paper is to examine how school-related parenting practices moderate the relationship between peers’ disengagement in school and academic performance among economically disadvantaged Haitian adolescents.   In the first chapter, we have made a statistical portrait of immigration in Quebec and discussed different aspects related to achievement among immigrant students. These data indicate that the academic difficulties that some of these students experience are complex and involve many factors. The second chapter explains how parents and friends are key actors in the academic success of Haitian students coming from disadvantaged background. We then assessed the moderating effect of school-related parenting practices on the relationship between peers’ disengagement in school and adolescents’ achievement in literacy. Results reveal that parental practices and peers’ disengagement toward school contribute directly (positively or negatively) to adolescents’ academic experience. In the third chapter, we finally discussed the role of the psychoeducator who intervene with Haitian students. It appears that there are many interventions that can be implemented with friends, parents, and teachers to promote the academic success of these students.  Our results highlighted the importance of considering peers’ disengagement from school and parenting practices in the study of academic difficulties among Haitian students coming from disadvantaged backgrounds. Further studies are however needed to understand the mechanisms underlying the contribution of these actors on adolescents’ achievement. These studies ought to include larger samples of participants coming from all regions of Quebec and all socio-economical backgrounds. In addition, these studies ought to rely on several informants and consider factors intrinsic to the student, such as his academic motivation or self-esteem.  Key words: School achievement; Parental practices; Peers’ disengagement from school; Haitian adolescents; Poverty.

Keyphrases: School achievement, Parental practices, Peers’ disengagement from school, Haitian adolescents, Poverty
Symptômes dépressifs et consommation problématique de substances psychoactives : effets modérateurs du contexte social

Of adolescents who use drugs, only a minority develops significant problems related to this drug use. It is then relevant to know and understand the processes by which this problematic consumption develops itself in order to be able to prevent it. This study examines the roles of depression symptoms and social relationships in the development of problematic drug use at the adolescence. More precisely, it aims at determining, with the help of a prospective correlational longitudinal design, if peers support, parental support and the quality of the teacher-student relationship have moderator effects on the relationship between depressive symptoms and problematic drug use. The sample used for this study is taken from the Stratégie d’Intervention Agir Autrement and is comprised of 4473 teenagers. Multiple linear regressions were completed and showed that depressive symptoms enhance the risk of a problematic drug use to be developed, whereas peers support impairs it. Contrary to what was expected, results show that parental support enhances the risk of developing a problematic drug use and that the teacher-student relationship has no significant impact. Moreover, peers support has a protective role, parental support intensifies the relationship between depressive symptoms and problematic drug use, whereas the quality of the teacher-student relationship attenuates it.

Keyphrases: Adolescence, Drug abuse, Problem drug use, Depression (emotion), Emotional states, Social support, Peer relations, Parental support, Teacher/student interaction, Adolescence, Protective factors
Articulations et négociations des identifications ethno-sexuelles des gais et
des lesbiennes d’origine libanaise à Montréal

The main objective of this thesis is to better understand how gays and lesbians of Lebanese background (primo-migrants or their descents) living in Montreal articulate and negotiate their ethno-sexual identifications through the mobilization of diverse capitals (economical, social, cultural and symbolic). Based on seven semi-directed interviews with five lesbians and two gays of Lebanese origin, this research examines, with an intersectional approach, the ways in which their identitary discourses are structured by social axes of division such as class, gender, sexualities, ethnicity, age, etc., on which they occupy majority and minority positions. The stories of our participants reveal, among other things, that there are different ways of representing oneself and being homosexual, and that individuals sharing non-normative sexualities do not necessarily inscribe themselves in the «global gay discourse». Chapters 1 to 3 are devoted to a theoretical and practical contextualization of the research. Chapter 4 consists of an analysis of the ethno-sexual subjectivities of the informants.

Keyphrases: intersectionality, identifications/identities, homosexualities, gays and lesbians, Lebanese, ethnicity
Étude observationnelle de la collision des vents dans les systèmes Wolf-Rayet+O

We present the results from three month-long observational campaigns related to WR+O colliding-wind binaries. This work focuses on southern-hemisphere systems that have not yet been previously studied in this context. To this we add the northern archetype colliding-wind system WR 140 (WC7pd + O5.5fc), which recently suffered another active periastron passage in 2009 January. The first two (spectroscopic) campaigns allowed us to update the orbital elements and to constrain the geometry of the colliding wind region and other fundamental parameters, for 6 binary systems: WR 12 (WN8h), WR 21 (WN5o+O7V), WR 30 (WC6+O7.5V), WR 31 (WN4o+O8), WR 47 (WN6o+O5) and WR 140. A short non-orbital (probably rotational) period was also detected in the WR component of one of our objects, WR 69 (WC9d+OB), with a much longer orbital period. The third (photometric) campaign revealed a surprisingly low level of variability in our sample of 20 WC8/9 stars. This supports the idea that pulsations are not very frequent in this type of star and are unlikely to be the main mechanism for dust formation, suggesting, by default, a predominant role of wind-wind collision.

Keyphrases: (Stars:) binaries: general, Stars: fundamental parameters, Stars: Wolf-Rayet, Stars: winds, outflows, Stars: Wolf-Rayet - circumstellar matter, Étoiles: carbone, Stars: carbon
Between truth and traume : the work of art and memory in Adorno

Analyzing the dialectical processes through which art works through the past, Between Truth and Trauma: The Work of Art and Memory in Adorno examines Adorno’s concept of memory. I argue that, for Adorno, the work of art both has and is a Zeitkern (temporal nucleus). I demonstrate that the reciprocal immanence of history in the work and immanence of the work in history allows for the past to be worked through. The first chapter examines how the past is preserved and negated by the work of art. The second chapter examines how the past is transcended through the work of art via the interpretive process. The final chapter looks at Adorno’s reading of work by Beckett and Brecht in order to illustrate the ability of the work of art to navigate between truth and trauma.

Keyphrases: Adorno, sursomption, Zeitkern, Adorno, memory, artwork, dialectics, sublation, 20th century German philosophy, interpretation, Zeitkern
Les liens sociaux entre les dépendants et le maître/patron dans la Correspondance de Cicéron

This paper will answer these questions: What were the social relationships between Roman masters/ingenui and slaves/freedmen? Were these relationships more often between ingenui and freedmen than ingenui and slaves? Did these relationships influence positively the slaves’ manumission in Cicero’s Letters? This paper will index and analyse the social relationships between ingenui and slaves/freedmen in the Letters. By social relationships, are meant friendships, marriage ties, sexual relations, masters’ and patrons’ estimation of their slaves/freedmen behaviours. Some pages will be devoted to the slaves and freedmen not mentioned in the Letters to explain this absence in the context of Rome in the last century BC. The study of social relationships between slaves/freedmen and masters, patrons and ingenui, in a social approach rather than a purely legal one, permitted the conclusion that friendships and affection often existed between slaves/freedmen and their masters/patrons or other ingenui of the Letters. In addition, this study proves that friendships and affectionate ties were more numerous and lasting between ingenui and freedmen than between ingenui and slaves. Accordingly, I defend the importance of friendships and affections ties in the manumission’s strategies of certain slaves.

Keyphrases: slavery, slave, Cicero, Social Relationships, marriage, Friendships, Freedman, Manumission, Mariage