NCube/papyrus huggingface dataset:
Post orthodontic effects of SARPE on sleep-disordered breathing in young adults as observed in a sleep laboratory

Introduction: Orthopedic expansion appears to have several positive effects on respiration as well as sleep quality, but a lack of studies examine these findings using SARPE on skeletally mature individuals.  The aim of this study was to evaluate post-SARPE stability as well as its effect on sleep disordered breathing after completing full fixed orthodontics.  Methods:  9 patients (average age 21, range 16-39) requiring SARPE underwent polysomnographic testing in sleep laboratory before SARPE (T0), after SARPE (T1), and after removal of full fixed appliances (T2).  Study models and anteroposterior cephalometric radiographs were also taken at the 3 time points.  Results:  Study model analysis showed significant relapse for intermolar and intercanine widths.  Anteroposterior cephalometric results were significant only for effective maxillary width.  There were no significant changes in any sleep stages, however a dramatic reduction in snoring as well as fewer stage shifts were observed.  Conclusions: Although statistically significant relapse was observed on study models and anteroposterior cephalometric radiographs, the dental relapse appears to be more clinically significant than the skeletal relapse.  SARPE appears to have a positive effect on sleep quality by reducing the snoring index as well as reducing transitions between sleep stages.

Keyphrases: SARPE, SLEEP, Snoring, Surgically assisted rapid palatal expansion
Effet d'une intervention infirmière de soutien favorisant l'autodétermination sur la pratique des auto-soins chez des patients atteints d'insuffisance cardiaque

Heart failure (HF) is a chronic disease with severe symptoms that may lead to repeated hospitalizations. To manage these symptoms, the treatment plan involves several self-cares, such low-salt diet and fluid restriction, which is sometimes difficult to achieve. The purpose of this randomized pilot study of two groups (n = 16 / group) was to assess the feasibility, acceptability and preliminary effectiveness of a nursing intervention aimed at improving the self-care practice in HF patient’s. The intervention is based on self-determination theory (SDT) which promotes autonomy in self-care practice. Seldetermination is enhanced by individual’s perceived competence, autonomy and relatedness. To sustain affiliation need, a primary caregiver participates in the intervention, which consists of five interviews with the experimental group (EG), two during hospitalization and three by a telephone follow-up after discharge. Interventions based on this theory include offering choice rather than imposing restrictions, avoiding criticism, encouraging empathy and positive reinforcement. The interviews were also used to guide the primary caregivers so they could themselves support their HF relatives’ with self-determination. The results support the feasibility and acceptability of the intervention evaluated in this study and help improve self-care practice with positive results for the majority of the hypotheses tested. These promising results will guide clinical nursing practice and provide avenues for future research.

Keyphrases: Heart failure, Self-cares, Family caregiver, Self-determination
Excrétion nasale et réponse sérologique à Mycoplasma bovis chez les génisses de remplacement de 0 à 7 mois d'âge dans 4 troupeaux laitiers au Québec: Étude de cohortes

In North America, Mycoplasma bovis is the most pathogenic mycoplasma found in cattle. The main diseases associated with it (respiratory disease, mastitis, septic arthritis and otitis median and/or internal) are a challenge to the dairy industry because of the difficulty to treat them and to prevent them by vaccination. The principal objective of this project was to study nasal shedding and serological response to M. bovis in replacement heifers, between birth and 7 months of age, in four dairy herds in Quebec. Eighty three pairs cow/heifer in 4 cohorts of dairy cattle were sampled monthly (heifers: 0 to 7 months; cows: 0, 1 and 5 months after calving). Nasal swabs and milk samples were analyzed by bacteriological culture and by indirect immunofluorescence. Circulating antibodies were detected by ELISA test. At birth, the serologic prevalence of heifers was significantly higher than the serologic prevalence of cows (P = 0,01). Transmission of M. bovis to heifers in milk and nasal shedding from cows was low. The average age (days) of a heifer for first nasal shedding and first seroconversion to M. bovis was far from the neonatal period: 77,5 ± 11,2 days (n = 22) and 96,8 ± 7,4 days (n = 36) respectively. Conclusion, cows were only a minor route of transmission of M. bovis to heifers, the main route of transmission was most likely the direct or indirect contact with other heifers shedding M. bovis in their upper respiratory tract.

Keyphrases: Mycoplasma bovis, Pneumonia, Arthritis, Mastitis, Nasal shedding
Rôle de l'acétylation du facteur de transcription IRF3

Innate immunity is our first line of defense against invading pathogens. This process is based on the recognition of invariable molecular patterns present on different pathogens by germ-line encoded receptors. In the innate immune response against invading viruses, the transcription factor Interferon Regulatory Factor 3 (IRF3) plays a major role in the regulation of type I interferons, priming the defense of infected and surrounding cells against viral infection. The phosphorylation and activation of IRF3 is regulated by the kinases TBK1 and IKKi. Here we suggest that acetylation is also an important post-translational modification in the regulation of this transcription factor. We have observed by immunoblot analysis a basal acetylation of IRF3, which is increased in the presence of its co-factor CBP and inhibited in the presence of its kinase TBK1. Also, we have identified on IRF3 eight different lysine residues subjected to acetylation using mass spectrometry and we have mutated these sites using sitedirected mutagenesis. We found that the K87R mutation inhibits IRF3-DNA binding in EMSA and leads to the transactivation of its promoter in luciferase assays. We also suggest that by masking the positive charge of the lysine 87 residue, acetylation negatively controls the activity of IRF3. Our group thus demonstrates for the first time the acetylation of IRF3 in a cellular model and suggests that this modification plays a role in the inhibition of the IRF3 transcription factor.

Keyphrases: IRF3, Anti-viral response, Type I interferon, IRF3, Acetylation
Advances in therapeutic risk management through signal detection and risk minimisation tool analyses

The four main components of therapeutic risk management (RM) consist of risk detection (identification), evaluation, minimisation, and communication. This thesis aims at addressing RM methodologies within the two realms of risk detection and risk minimisation, through the conduct of two distinct studies: i) The development and evaluation of a data mining tool to support signal detection using health care claims databases, and ii) A systematic review to characterise risk minimisation interventions (RMIs) implemented so far. The data mining tool is based on a Maximised Sequential Probability Ratio Test (MaxSPRT), using drug dispensing and medical claims data found in the Quebec health claims databases (RAMQ). It was developed and validated in a cohort of 87,389 community-dwelling elderly aged 66+, randomly sampled from all elderly drug plan members between 2000 and 2009. Four known drug-AE associations and two "negative" controls were used. The systematic review on RMIs is based on a literature search as well as a review of the websites of six main regulatory agencies. Types of RMIs have been summarized and implementation gaps identified. The data mining tool detected signals in one of four of the known drug-AE associations. Major contributions are: a) The first signal detection data mining tool applied to a Canadian claims database; b) Methodological improvements over published methods by considering the depletion of susceptibles effect and adjusting for overall health status to control for prescription channelling. The review yielded 119 distinct RMIs from the literature and 1,112 from the websites. The review demonstrated that an increase in RMI numbers among websites occurred since the introduction of guidances in 2005, but their effectiveness remains insufficiently examined.

Keyphrases: Therapeutic risk management, Risk minimisation, Pharmacovigilance, Pharmacovigilance, Data mining, Data mining, Drug safety, Signal detection
Le cardinal Paul Grégoire et l'Église de Montréal (1968-1990)

The recent historiography on Catholicism in the Province of Québec has neglected the life and episcopate of Paul Grégoire, archbishop of Montréal from 1968 to 1990. Yet his episcopate covers a crucial period in the history of the Province and the Catholic Church. When he became archbishop of Montréal in April 1968, the Province of Québec was still in the midst of its Quiet Revolution, a period of growing change in mentalities and morals brought on by a rejection of the past and the rising tide of secularization and dechristianization. For its part, the Catholic Church was going through its own renewed identity process as a result of the Second Vatican Council which had ended December 1965. It is at the juncture of these two renewed identities that Archbishop Grégoire’s episcopate took shape. The prelate had to cope with many new challenges both on the external and internal fronts. Ad extra, he had to meet the challenges of a new social order extremely unfavorable towards his Church, particularly concerning the denominational school system. Ad intra, he had to implement the Council reforms throughout his diocese and in so doing encountered a great deal of resistance and much misunderstanding which sometimes led to crises casting doubt on his leadership. At the time of his retirement in March 1990, Cardinal Grégoire had seen the Catholic Church lose the greater part of its moral and spiritual influence on the Montréal and Québec societies. He had set out to mold the Church of Montréal according to his doctrinal orientation, his discipline and his style. Even while taking into consideration that his personality was not best suited for the task, we fail to see how he could have significantly countered the great opposing forces at work. The study of his episcopate clearly reveals this.

Keyphrases: Paul Grégoire, Quebec Catholicism, Church of Montreal, Paul Grégoire, Assembly of Quebec Catholic Bishops, Quiet Revolution, Secularization, Dechristianization, School denominationalism
Rapport à soi et citoyennetés alimentaires :
diagnostic d'une politique des plaisirs

This dissertation examines food and eating as a social discourse on “what to eat” that unfolds with a remarkable intensity within the current advanced liberal regime of government. More specifically, I propose to conceive of this intensity as participating of an investment of food and eating as a privileged site in the production of articulations of the ethics of the care of the self (ethical self-formation) and of a normative understanding of citizenship. This productivity is put forth by means of an “exemplification” of clusters of regularities in food and eating discourses that appear to be the most prominent in terms of their effects of citizenship.   The first of these clusters is explored through an analysis of Jamie’s School Dinners, a campaign for a reform of the British school dinner system that I consider exemplary of discourses that are currently positing (a specific) food culture as an issue of cultural citizenship. I then look at some operations at play in Mettez le Québec dans votre assiette!, a social marketing campaign in favour of local food that, I contend, is exemplary of the contemporary production of “local eating” as an expression of trust and of patriotism toward a nation defined by its terroirs. I finally turn to Michael Pollan’s book In Defense of Food. An Eater’s Manifesto as an example of co-presence of the two clusters of regularities already discussed and a third one (“nutritionism”) that I regard as a rearticulation of the “duty to be well” put forth by nutritional science. This dissertation concludes on an examination of some of the effects of this co-presence and of the food citizenships that it informs. More specifically, I argue that these citizenships are pervaded by a politics of pleasure which works through anxiety (toward an uncertain future) and according to a generational logic which unfolds simultaneously in the space of the nation and in that of the family.

Keyphrases: citizenship, ethics of the care of the self, food and eating, advanced liberalism, pleasure
Peut-on être blâmé pour ses croyances? : le déontologisme épistémique face au problème de l'involontarisme doxastique

Can we sometimes be blamed for our beliefs ? According to epistemic deontologism, the ordinary practice of blaming and criticizing people for their beliefs is a legitimate one. However, some philosophers argue that despite its pervasiveness in everyday life, doxastic blame is never appropriate. According to the argument from doxastic involuntarism, we can never be blamed for our beliefs since (1) we can be blamed for a belief only if it is under our voluntary control, and (2) our beliefs are never under our voluntary control.  The goal of this thesis is to determine whether deontologists can reply convincingly to this argument. In other words, can we sometimes be blamed for our beliefs despite what anti-deontologists claim, or do we have to accept the argument from doxastic involuntarism and reject the practice of doxastic blame ?  In order to answer that question, I first clarify the anti-deontologist argument by making more precise the nature of its central thesis: doxastic involuntarism. I then review different strategies proposed by deontologists to defend doxastic blame against this argument. Given the failure of these replies, I propose an alternative defense of deontologism according to which doxastic involuntarism is not incompatible with doxastic blame. If this reply is sound, then we do not have to accept the anti-deontologist argument: we can sometimes be blamed for our beliefs.

Keyphrases: Philosophy, Epistemology, Epistemic normativity, Belief, Doxastic involuntarism, Blame, Responsibility, Reasons for belief, Ethics of belief
Age and species related variation in the development of growth plates of the knee and implications for the locomotion of Australopithecus afarensis

Understanding the evolution of bipedality is a critical part of research in paleoanthropology, as it is the single-most important trait used to identify fossils as belonging to the hominin lineage. The topography of the infradiaphyseal plane could provide insight into the locomotor behaviour of fossil species, but has not been studied extensively. This trait directly reflects differences in locomotion, as the surface changes to resist loads incurred by regular movement. Humans have an infradiaphyseal plane that is relatively flat, while this feature is very convoluted in great apes.   This project studied this feature in the femur and tibia quantifiably to allow for statistical comparisons between species and to provide a better understanding of its ontogenic development. Three-dimensional landmarks were recorded from the metaphyses of the knee in humans, chimpanzees, gorillas, orang-utans, and three Australopithecus afarensis fossils. Using these landmarks, angles formed by the salient points of these planes were analyzed to confirm observations that development and species have a significant effect on the topography of growth plates of the knee. Carrying angles of the femur and tibia were also measured and analyzed. Results revealed that development and species, and by extension, mode of locomotion, have a significant effect on the overall metaphyses of the knee, especially on the sagittal plane. It was also found that A. afarensis have values that overlap human and great ape ranges, suggesting this species had probably retained an arboreal component in its regular locomotion.

Keyphrases: Australopithecus afarensis, Bipedality, Knee, Obliquity angle, Growth plates, Metaphysis, Biomechanics
Rôle différentiel des cellules épithéliales intestinales et pulmonaires dans le recrutement des cellules Th17 vers les sites de réplication du virus de l'immunodéficience humaine de type 1

The HIV-1 infection is associated with a severe loss of CD4+ T-cells with Th17 polarization from the gut-associated lymphoid tissues (GALT). These alterations lead to microbial translocation, which is a cause of chronic immune activation and disease progression in HIV-infected subjects. Epithelial cells (EC) play a critical role in maintaining mucosal integrity and homeostasis in the GALT by mechanisms including recruitment of innate (e.g., neutrophils) and adaptive immunity cells (e.g., Th17 cells). Neutrophils produce antiviral molecules (e.g., -defensins) that may limit HIV replication at mucosal sites. Th17 cells play a dual role in HIV pathogenesis. Th17 cells contribute to the defence against different opportunistic pathogens by increasing the ability of epithelial cells to attract neutrophils in an IL-17-dependent manner. On the other hand, Th17 cells play a deleterious role in HIV pathogenesis as they are sites of productive viral replication and a source of pro-inflammatory cytokines. The frequency of Th17 cells is decreased in the GALT but not in the lungs of HIV-infected individuals, suggesting distinct mechanisms of Th17 recruitment in these anatomic sites in the context of HIV pathogenesis. In this manuscript we tested the hypothesis that HIV differentially interfere with the ability of intestinal but not pulmonary EC to produce chemokines that attract Th17 cells and neutrophils. We demonstrated that both intestinal and pulmonary EC produce chemokines that specifically attract Th17 cells (CCL20) and neutrophils (CXCL8) upon stimulation with the pro-inflammatory cytokines IL-1 and TNF- . TNF-α acted in synergy with IL-17, a recently identified « danger signal », and increases the capacity of intestinal but not pulmonary EC to produce CCL20. This synergistic effect can be explained by the preferential upregulation of IL-17 receptor expression on intestinal EC upon TNF- stimulation. The exposure of intestinal EC to HIV did not affect their ability to produce CCL20 and CXCL8; however, exposure to HIV altered the production of these chemokines by alveolar EC, consistent with their selective permissiveness to infection. In conclusion, our results demonstrate that (i) HIV does not interfere directly with the ability of intestinal EC to attract Th17 cells and neutrophils and that (ii) the ability of intestinal EC to recruit the Th17 cells via CCL20 production is selectively dependent on the synergy between TNF- and IL-17. Thus, the depletion of Th17 cells and the shortage in IL-17 in the GALT of HIV-infected subjects may preferentially lead to functional alterations of the intestinal barrier resulting by the alteration of Th17 recruitment in response to CCL20.

Keyphrases: Infection a VIH, HIV Infection, Th17 cells
Effet du développement résidentiel sur l'habitat et la distribution des macrophytes dans les lacs des Laurentides

Effects of residential development on macrophyte habitat and distribution in the littoral zone of six lakes of the Laurentian region were assessed with quadrats and small cores. Residential development increases the proportion of open area which reduces coarse woody debris inputs and enhances erosion and nutrient inputs into the sediments. Sediments are then finer, more compact and contain less organic matter. With less important proportion of forested area in developed watersheds, nutrients inputs are then more important in sediment as well. These changes in macrophyte habitats enhance coverage of the littoral by aquatic plants in developed lakes. Submerged species are also favoured at the expense of floating species that are more typical of pristine conditions. Despite the limitation of aquatic plants biomass in some lakes, macrophyte biomass is higher in developed lakes and showed signs of a buffering effect on nutrient inputs, especially for phosphorus. Macrophyte nutrient content represented values between 35 and 230% of annual phosphorus inputs by residents on the shore of developed lakes and between 79 and 659% of the annual nitrogen inputs. Sediments are enriched by macrophytes at their senescence and therefore contain more nutrients than the water column and macrophytes for all lakes. The greater presence of submerged macrophytes, and the higher amount of nutrients in macrophytes of developed lakes combined with absence of phytoplankton blooms in spite of greater nutrient supply, suggests that Laurentian lakes are in an early stage of eutrophication.

Keyphrases: macrophytes, littoral, macrophytes, littoral, residential development, sediment, phosphorus, nitrogen, eutrophication
Ethnomusicologie et esthétique : de la réflexion épistémologique à la recherche de terrain : une étude comparative de la vocalité de tradition orale au sud de l’Italie

This dissertation addresses epistemological and methodological problems related to studying the aesthetics of traditional vocal practices in Salento.  In the first two sections of the dissertation, I examine from an epistemological perspective the ontological status of aesthetic experience and the relevance of studying aesthetics in ethnomusicological fieldwork. In the third and fourth sections I present the results of my fieldwork research, conducted with two distinct socio-cultural groups of Salentine singers: traditional singers and revival singers. In addition to coming from two different generations, these two groups of singers are also rooted in two distinct socio-cultural and economic milieux: in one case, the agro-pastoral world that subsisted in Salento until the 1960s; in the other case, contemporary society, which since the second half of the 1970s has been marked by urbanization, globalization, and the shift to a service economy.  This dissertation explains in detail how each of the two groups of singers experience aesthetics. I develop two different investigations based on the socio-cultural and musical characteristics peculiar to each generational context, studying various kinds of aesthetic expressions and especially the singers’ discourse. In the conclusion I compare the results of the investigations I carried out with the two groups. Besides considering the variety of criteria, behaviors, reactions, and other factors that characterize the aesthetic experience of these two generations of singers, I propose that there exists a single, constant paradigm of aesthetic criteria that is valid for both traditional singers and for revival singers.

Keyphrases: Salento, Tradition orale, World music, Aesthetics, Vocal practices, Salento, Southern Italy, Rural universe, Revival, Oral tradition, World music