Transition nutritionnelle et double fardeau de la malnutrition chez des adultes de Ouagadougou au Burkina Faso (Afrique de l’Ouest)

This study is a part of a project on the double burden of malnutrition in sub-Saharan Africa, developed and implemented by TRANSNUT, a WHO collaborating centre on nutrition changes and development, of the Department of Nutrition, Université de Montréal, in collaboration with its partners in Burkina Faso (Institut de Recherche en Sciences de la Santé and Institut Supérieur des Sciences de la Population). The study is among the first to focus on the double burden of malnutrition in French speaking Africa and aimed to describe the occurrence of the double burden among adults living in Ouagadougou, Burkina Faso, by determining its prevalence and to what extent it was related to life style factors. More specifically, the study aimed to: 1) describe nutrition deficiencies, cardio-metabolic risk factors (CMRF) and double burden phenotypes, to 2) examine the relationship between lifestyle characteristics and the double burden of malnutrition, and finally, 3) to examine the relationship between subclinical inflammation and both CMRF and nutrition deficiencies. We hypothesised that: ‘among the adults of Ouagadougou, the more frequent phenotype of double burden of malnutrition is the association of overweight/obesity with at least one micronutrient deficiency, which is more prevalent in women’; ‘an inadequate quality of the diet related to poor socioeconomic and living conditions is associated to both CMRF and micronutrients deficiencies’ and finally, that ‘subclinical inflammation is a mediator variable between lifestyle and both CMRF and nutrition deficiencies’. We carried out a population based cross-sectional study, descriptive and analytical, with a random sample of 330 adults aged 25-60y, selected from the population observatory of Ouagadougou located in the northern district. This sample was stratified in three income groups using household assets as a proxy of socioeconomic status, with 110 subjects in the following three income strata: low, middle and high. Each subject provided sociodemographic, anthropometric, clinical and lifestyle data and a blood sample for the assessment of the following study variables: age, and socioeconomic conditions (food insecurity, education and income); lifestyle factors (dietary intake and diet quality, physical activity, alcohol and tobacco consumption, body image perception, and psychosocial stress); subclinical inflammation; CMRF (overweight/obesity, high blood pressure or hypertension, hyperglycaemia, dyslipidemia, insulin resistance); nutritional deficiency markers ( underweight, anaemia, iron and vitamin A deficiencies); the double burden of malnutrition phenotypes featured by combining CMRF with nutrition deficiencies factors.  We reported a high prevalence of overweight/obesity, abdominal obesity, hypertension, hyperglycaemia, insulin resistance and low concentration of high density lipoprotein cholesterol (HDL-C), which was 24.2%, 12.5%, 21.9%, 22.3%, 25.1%, and 30.0% respectively. When using International Diabetes Federation (IDF) cut-offs for abdominal obesity, high blood pressure, and hyperglycaemia, their prevalence were 23.5%, 36.1%, and 34.5% respectively. Anaemia, iron and vitamin A deficiencies and underweight were found in 25.5%, 15.4%, 12.7%, and 9.7% of subjects, respectively. Women were more affected by both CMRF and deficiencies than men. When combining CMRF and deficiencies within the same individual, the double burden of malnutrition was reported in 23.5% of subjects and even in 25.8% of them when IDF cut-offs for abdominal obesity, high blood pressure, and hyperglycaemia were used. Two main phenotypes were reported: the co-occurrence of ‘overweight/obesity with at least one micronutrient deficiency’, with a prevalence rate of 7.8% (11.8 % ♀ vs. 3.4 % ♂); and the co-occurrence of ‘CMRF other than overweight/obesity with at least one micronutrient deficiency’, with a prevalence rate of 9.0% (12.4 % ♀ vs. 5.4 % ♂). This prevalences was higher when using IDF cut-offs instead of WHO cut-offs. Finally, 72.9% of the subjects exhibited at least one CMRF and even 81.2% of the subjects when using IDF cut-offs. We also identified in this study population two dietary patterns: “urban” and “traditional”. Nutritional deficiencies were associated with ‘traditional’ dietary pattern, whereas CMRF were found in both patterns without statistical difference. The “urban” dietary pattern was significantly more common in men, high income subjects, whereas low income subjects and women were significantly more numerous in the ‘traditional’ one.  Time devoted to sedentary activities was significantly higher than time spent in moderate to vigorous activities. Time in moderate to vigorous activities was significantly and negatively associated with body mass index (BMI), waist circumference (WC), and body fat mass, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceridemia, and low density lipoprotein cholesterol (LDL-C), while BMI and WC were associated to sedentary time. The double burden of malnutrition was associated to low income status, women, and sedentary time.  We reported that 39.4% of the subjects exhibited subclinical inflammation, which was independently and positively associated with serum ferritin, BMI, WC, body fat mass, and negatively to HDL-C.  Body image evaluation revealed that overweight was perceived as desirable body image among the study subjects. Psychosocial stress was associated with hypertension and subjects who probably faced stunting during infancy (using Cormic Index) exhibited significantly higher prevalence of overweight/obesity, abdominal obesity and insulin resistance. The results allowed us to achieve the study objectives and confirm our hypotheses. CMRF represents an overwhelming issue in adults of Ouagadougou complicated with their coexistence with nutritional deficiencies, also highly prevalent. A nutrition transition is at play in the city, contributing to lifestyle changes favorable to the double burden of malnutrition in such a context where the early life nutritional conditions of the subjects may put them at further enhancement of CMRF. The progression of this prevalence can still be averted or at least be slowed if suitable actions were taken from now.

Keyphrases: Burkina Faso, Micronutrient deficiencies, Cardio-metabolic risk factors, Subclinical inflammation, Double burden of malnutrition, Adults, Burkina Faso, West Africa