NCube/papyrus huggingface dataset:
Un pont entre les obédiences : expériences normandes du Grand Schisme d'Occident (1378-1417)

Between 1378 and 1417, the Catholic Church was divided between two, and then three contending popes. While Urban VI and his successors settled in Rome, Clement VII and his successor, Benedict XIII, returned to Avignon. This dissertation documents and analyses the multiple experiences known in Normandy in reaction to the Great Western Schism. Norman commitments to resolve this division were plural and they were expressed in numerous manners. Relying on Vatican archives, University of Paris and local archives, this study demonstrates the different reactions that coexisted in Normandy in response to the Great Western Schism. Although the Norman nobility was generally favourable to the Avignon popes, officially recognized by the King of France, important waves of resistance to that papacy were also expressed amongst Norman clergymen, prelates, as well as university students and professors. This resistance led some to choose exile, in order to recognize the Roman popes. Those Norman exilees, although they formed a modest community, had considerable influence in the Roman obedience, and they have been the object of very little scholarly attention. Amongst the vast majority of those who remained in the obedience of Clement VII, many Norman intellectuals were known for being very critical, even being enemies of the Avignon popes. The relationships that exiled Normans maintained with their colleagues who remained in Clément VII’s obedience played a very important role in the dialogue between obediences that led to the council of Pisa in 1409. This dissertation highlights the multiplicity of Norman attitudes in response to the Great Western Schism, it deepens our knowledge of the various Norman groups touched by the division and it improves our understanding of the different debates that surrounded the crisis. It also allows to further the reflection on the questions of how the schism affected the notion of obedience, and of the Norman networks at work during that period.

Keyphrases: XIVe siècle, Great Western Schism, Normandy, Obedience, Networks, Papacy, 14th century, 15th century
Effets de l'activité physique durant la grossesse sur le cerveau de la mère et de l'enfant

Pregnancy is a pivotal moment in life when a woman reconsiders the value of each of her lifestyle choices. It is well known that physical activity brings benefits for cognition in children and adults, but is this also the case for pregnant women? What about their children? The overall objective of this thesis was to examine the effect of the interaction between physical activity and pregnancy on the cognitive functions of the mother and of the child. A first study shows that the cognition of pregnant women decreases during the third trimester and is not affected by their fitness level. A second study shows the effects of an exercise session on several cognitive abilities of pregnant women. We observed that pregnant women's self-monitoring ability is poorer than that of control women and that pregnant women's self-monitoring and sustained attention diminish after a bout of acute cardiovascular exercise. Finally, a third study shows the impact of physical activity performed throughout pregnancy on the brain of the newborn. This study demonstrates that newborns of active mothers have more mature neurophysiological responses than children of sedentary mothers. Taken together, these results demonstrate that pregnancy induces cognitive deficits. In addition, the cognitive functions of pregnant women are impaired as a result of an exercise session. Thus, they should not plan to exercise before a cognitively demanding activity. Nonetheless, women should still exercise regularly during pregnancy to provide the best possible start in life for their child.

Keyphrases: Exercice, Cognition, MMN, Pregnancy, Physical activity, Exercise, Development, electroencephalography, Mismatch negativity, Newborn
Le développement positif des jeunes en contexte sportif parascolaire : évaluation du programme d’intervention psychosociale Bien dans mes Baskets

The main objective of this thesis was to explore the personal development of youth at risk of delinquency and dropout through their involvement in a psychosocial intervention program named "Bien dans mes baskets" (BdmB). This program uses extracurricular basketball as an intervention tool among youth facing various difficulties. It is worth noting that almost all the coaches have professional training in social work or related fields. This thesis presents the results of three studies as parts of a broader research project dealing with the evaluation of the BdmB program. The first study explored the transfer process of the life skills targeted by the BdmB program to other activity fields. Semi-structured interviews were conducted with 14 men and seven women former athlete-students. Our results suggest that, throughout the adult life, three main factors seem to have played a role in the transfer process involving life skills developed as part of BdmB, namely the presence of contexts favoring experiential learning, the relative value granted to the different activity fields and the life trajectory. Our data also shows that beyond the transfer process on an individual scale, a transfer can also occur within the community. The aim of the second study was to explore how participation in BdmB could foster the process of empowerment. Semi-structured interviews were conducted with seven former female participants of BdmB. Our results suggest that a team sport can lead to empowerment through positive socialization, especially when combined with psychosocial intervention. This improvement was most likely the result of cumulative learning experiences including the development and transfer of life skills, the capacity to resist negative external influences as well as the positive impact of experiences in BdmB on their academic aspirations and persistence. The aim of the third study was to evaluate the impact of BdmB program on sense of belonging to school and the presence of social support. A quasi-experimental design was used to evaluate the impact of the program among current participants. The intervention group consisted of the athlete-students of BdmB and the comparison groups consisted of the students from the same school who are not participating in the program, and taking into account whether they are involved or not in sport participation. Individuals were surveyed two times using a self-administered questionnaire over a period of two academic years. Results indicate that the intervention group has developed a better sense of belonging to school and has a better social support compared to comparison groups.

Keyphrases: Adolescent, Sport, Empowerment, Life skills, Sense of belonging
Étude pangénomique de la variabilité dans le nombre de copies liée à l’hypertension artérielle et ses anomalies métaboliques associées

Essential hypertension (HT) is a multifactorial complex disease with a strong genetic component. However, little is known about the effects of copy number variance on HT. We hypothesized common Copy Number Variants (CNVs) could increase or decrease the risk for HT. We performed GWAS of CNVs with HT and, with HT and Type 2 Diabetes (T2D), in 21 families of the Saguenay-Lac-St-Jean region of Quebec (FC) affected by early-onset hypertension and dyslipidemia. Replication was tested in a cohort of 3349 unrelated diabetic subjects of Caucasian origin from the ADVANCE trial. Replication was also tested in 187 individuals from the Czech Post-Monica (CPM) cross-sectional survey, ascertained by the presence/absence of albuminuria and/or metabolic syndrome. We performed locus-specific transcriptional analyses in 134 subjects from the CARTaGENE population cohort.  We identified two CNV Regions (CNVRs), at 17q21.31, associated with HT and T2D in FC and associated with hypertension in ADVANCE diabetics. A statistical model of association including both CNVRs underlined the main effect size of CNVR1 on insulin resistance, T2D early onset and duration, and risk for cardiovascular diseases (CVD). CNVR1 appeared to influence LOC644172 expression, whose transcript abundance was associated with the prevalence of HT and T2D, and strongly with the risk of CVD and vascular age (P<2×10-16). Our results suggest carriers of copy-number gain at these 17q21.31 loci, principally at the CNVR1 locus, undergo premature β-cell functional deregulation and insulin resistance, due to increase dosage of the LOC644172 pseudogene, which might in turn affect the regulation of expression of its functional paralog, MAPK8IP1. We also report six different CNVR loci, highly heritable and contributing to the risk of hypertension, in French Canadians. The combined CNV risk score appeared robustly related to prevalence of hypertension (p=2×10-10) and age at diagnosis of hypertension. In FC, this combined CNV risk score model showed a C-statistic of 0.71 for HT and appeared as powerful as Framingham HT risk score in predicting hypertension in individuals aged less than 25. We validated the association of a new locus, 19q13.12 deletion-CNVR, with hypertension, in CPM. FFAR3 surrounds this 19q13.12 deletion-CNVR. It has been demonstrated that in mice, a portion of propionate hypotensive effect is mediated by Ffar3, and involves a cross-talk between the gut microbiota and the renal-cardiovascular system. The identified CNVRs appear to influence genes and QTLs mainly related to immune and inflammatory responses and renal damaged and repair. Some CNVRs are exclusive to primates. This study suggests that additive and interactive actions of multiple copy-number variants are involved in the etiology of hypertension or of hypertension associated with T2D.

Keyphrases: Hypertension, QTL, GWAS, T2D, Copy number variant, CNV, CNVR
Vers un marché du carbone au Québec : éléments de réflexion à la lumière de l'analyse économique du droit

As part of the launch of the Western Climate Initiative, the province of Québec has implemented on January 1st, 2012, one of the first carbon emissions trading system in North America (CETS). Such a system could in time become part of the emerging regulated market for carbon on the continent. However, it belongs to a category of economic instruments still timidly explored in legal literature. The CETS forms part of the economic regulation of the environment and is based on concepts drawn from the economic theory such as scarcity, property and the market. The thesis aims at contributing to the dialogue between jurists and economists around the design and implementation of this type of instrument.  In order to explore its architecture and uncover the legal issues at play, we applied the teachings of law and economics in order to reveal the underlying dynamics of incitation and efficiency built in the CETS regulations and highlight the pivotal role played by the formulation of legal rules in their operationalization. The exploration is conducted through a progressive modelling of the exchange of emission rights, which takes into account transaction costs. The resulting model brings to light friction points that are likely to occur at different stages of the exchange of emission rights and might negatively impact its economic efficiency.  The thesis contributes to the advancement of knowledge by offering jurists a coherent and intelligible legal analysis of the rules governing the exchange of emission rights in the CETS. Thus, it provides a systematic arrangement of these rules structured around the diversification strategies of the exchange and the institutionalization of its terms. It also raises market surveillance issues, particularly of the carbon derivatives market, in a context of fragmentation of market authorities.

Keyphrases: Western Climate Initiative, Climate change, Greenhouse gas emissions, Economic instruments for environmental protection, Emissions trading, Emission rights, Carbon market, Law and economics, Property rights, Transaction costs, Regulatory efficiency
La régulation du commerce électronique global

The roll out of e-commerce on a global market gives rise to a number of legal questions. On one hand, the law is conceived on a national scale based on the social context, which itself is dependent on its history and culture, and on the other hand, global e-commerce has very unique characteristics: dematerialization, ubiquity and a cross-border dimension. Such a confrontation is likely to jeopardize the legal security of parties in their online commercial transactions, in addition to the trust necessary for their development. National territories, by limiting the effective State power, present a scale issue: regulating a global phenomenon confronted by multiple territorial sovereignties. The normative framework of global e-commerce is now starting to develop, partly, at the non-state level confirming the erosion of States monopoly in the regulation of the global legal relations. Normativity becomes the result of a normative game, open not only as for regulation actors, but even as for the qualification of the norms involved in this regulation. With regard to the growing complexity of normativity, States intervene in order to attempt to reconcile new practices with the rule of law, while aiming to define the playing fields and to harmonize the behaviour of the economic players. National law systems are learning to interact with multiple norms from different sources. This evolution reflects the articulation of changes in normativity dynamic with the phenomenon of e-commerce globalization.

Keyphrases: Regulation, E-commerce, Globalization, Normativity, Trust, Postmodernism
The involvement of nitric oxide in bovine follicular development and ovulation

Understanding the paracrine events that regulate fertility in the cow is necessary not only because of the agricultural importance of this species, but also its potential use as a model for humans. Nitric oxide (NO), a free-radical gas, has been implicated in follicular growth and ovulation in rodents and other species, but the cow is an intriguing enigma: NO is produced by bovine granulosa cells and is regulated by FSH, but the presence and the expression pattern in granulosa cells of the enzymes responsible for NO synthesis (NOS) throughout follicular growth are unclear. The objectives of the present thesis were (1) to elucidate the mechanism of control of NOS and the consequences of nitric oxide production for granulosa cell function during follicle development in cattle; and (2) to determine the regulation of NOS during the LH-induced ovulatory cascade in bovine granulosa cells and whether NOS activity is critical for the ovulatory cascade in this species. The results are separated in 2 articles. In the first article, the regulation of NOS2 in bovine granulosa cells was explored. Abundance of mRNA encoding NOS2 was stimulated by FSH and IGF1 through increased estradiol, and a blockade of estradiol action consequently lowered NOS2 mRNA levels. Further, inhibition of NOS activity increased apoptosis in granulosa cells in vitro. In the second article, it was demonstrated that the LH surge induces NOS activation in granulosa cells, and that NOS activity induces the production of NO, which is essential for EREG/AREG/PTGS2 expression, critical genes in the LH-induced ovulatory cascade. Together, the results presented in these 2 articles suggest that physiological levels of NOS activity may contribute to growth and survival of granulosa cells, and also indicate that NO may be essential for ovulation in cattle.

Keyphrases: NOS, Follicule, Ovulation, Nitric oxide, Ovary, Follicle, Granulosa cells, Apoptosis, Ovulation, Cow
Différences culturelles au travail : impact sur l'intégration et la santé des travailleurs étrangers

This thesis focuses on the impact of cultural differences on foreign workers’ integration and health. Cultural differences are assessed using the concept of cultural distance between Hofstede’s cultural dimensions, integration using the concept of acculturation, and health using the concept of psychological health at work. The immigrants’ personal resources (proactivity, optimism and resilience) are also considered. The study was conducted in two call centers of a major financial cooperative in Quebec. The sample consists of 100 first generation immigrants in Montreal. The study’s results highlight the significant but moderate impacts of cultural differences on both the psychological health and the acculturation style at work, as well as the significant impact of personal resources (resilience) on foreign workers’ acculturation and psychological health at work. Strong cultural differences would generate greater psychological well-being at work and would engender the adoption of integrative acculturation style. Resilience stands out as a key personal resource for an immigrant’s health. The results further underline the particular role of the work sphere for foreign workers, with scientific literature supporting the idea that the workplace would have a significant impact on their psychological health. In addition to the above, a list of research limitations, recommendations for improvement and paths of action have been suggested.

Keyphrases: Immigration, Acculturation, Cultural diversity, Hofstede's cultural dimensions, Psychological health at work, Cultural distance
Analysing artefacts dependencies to evolving software systems

Program maintenance accounts for the largest part of the costs of any program. During maintenance activities, developers implement changes (sometimes simultaneously) on artefacts to fix bugs and to implement new requirements. Thus, developers need knowledge to identify hidden dependencies among programs artefacts and detect correlated artefacts.  As programs evolved, their designs become more complex over time and harder to change. In the absence of the necessary knowledge on artefacts dependencies, developers could introduce design defects and faults that causes development and maintenance costs to rise. Therefore, developers must understand the dependencies among program artefacts and take proactive steps to facilitate future changes and minimize fault proneness. On the one hand, maintaining a program without understanding the different dependencies between their artefacts may lead to the introduction of faults. On the other hand, when developers lack knowledge about the impact of their maintenance activities, they may introduce design defects, which have a negative impact on program evolution. Thus, developers need mechanisms to understand how a change to an artefact will impact the rest of the programs artefacts and tools to detect design defects impact.   In this thesis, we propose three principal contributions. The first contribution is two novel change patterns to model new co-change and  change propagation scenarios. We introduce the Asynchrony change pattern, corresponding to macro co-changes, i.e., of files that co-change within a large time interval (change periods), and the Dephase change pattern, corresponding to dephase macro co-changes, i.e., macro co-changes that always happen with the same shifts in time. We present our approach, named Macocha, and we show that such new change patterns provide interesting information to developers.  The second contribution is proposing a novel approach to analyse the evolution of different classes in object-oriented programs and to link different evolution behaviour to faults. In particular, we define an evolution model for each class to study the evolution and the co-evolution dependencies among classes and to relate such dependencies with fault-proneness.  The third contribution concerns design defect dependencies impact. We propose a study to mine the link between design defect dependencies, such as co-change dependencies and static relationships, and fault proneness. We found that the negative impact of design defects propagate through their dependencies.  The three contributions are evaluated on open-source programs.

Keyphrases: Change Pattern, Stability, Change Period, Evolutionary history, Co-evolution, Reverse engineering, Fault-proneness, Anti-patterns, Change proneness, Design patterns
Problèmes de tournées de véhicules avec contraintes de chargement

In this thesis, we study mixed vehicle routing and loading problems where a constraint is imposed on delivery sequences. More precisely, the items in the loading area of a vehicle must be directly accessible, without moving any other item, at delivery time. These problems are often found in the transportation of large objects (furniture, appliances). The first paper proposes a branch-and-cut algorithm for a variant of the single vehicle pickup and delivery problem, where the loading area of the vehicle is divided into several stacks. When an item is picked up, it must be placed on the top of one of these stacks. Conversely, an item must be on the top of one of these stacks to be delivered. This requirement is called “Last In First Out” or LIFO constraint. The second paper presents another branch-and-cut algorithm for a vehicle routing and loading problem with two-dimensional rectangular items. The loading area of the vehicles is also a rectangular area where the items are taken out from one side. A constraint states that the items of a given customer must be directly accessible at delivery time. The last paper considers a stochastic vehicle routing and loading problem with two- dimensional rectangular items where the dimensions of some items are unknown when the routes are planned. However, it is possible to associate a discrete probability distribution on the dimensions of these items. The problem is solved with the Integer L-Shaped method.

Keyphrases: méthode L-shaped, Vehicle Routing Problem, Loading constraints, Stochastic two-dimensional items, L-shaped method