NCube/papyrus huggingface dataset:
Perception de la force musculaire et de la distribution du poids lors d’activités motrices chez le sujet sain

Results of recent studies support the idea that perception of force would have an important role in performing functional tasks such as sit-to-stand (STS). However, very few studies have focused on the quantification of the accuracy with which healthy individuals are able to perceive muscular force. Furthermore, no study has assessed the perception of weight-bearing distribution during the STS in healthy individuals. The purpose of this study was to provide evidence on the capacity to perceive muscular force and weight-bearing distribution in simple and complex tasks in healthy individuals. This study was conducted with 31 individuals, divided into two main age groups (<50 years > 60 years). Its first objective was to quantify the errors in perception of force during a static contraction of knee extensors and to compare these errors between young and elderly groups. Results showed that the absolute and raw errors are greater for force levels higher than 50% of maximum voluntary contraction (MVC) and that raw errors are greater in young participants for high force levels. This study’s second objective was to assess the effect of different sensorimotor references on the magnitude of errors of force perception. The results showed that a reference of 50% MVC presented to the participant beforehand or a simultaneous contraction of hand grip muscles reduced the raw and absolute errors of perception at the level of 70% MVC. A third objective was to quantify the errors of perception of weight-bearing distribution during STS and to measure the effect of age on these errors. The results showed that younger and elderly participants have an ability to perceive their weight-bearing distribution with absolute and raw errors varying respectively from 2.9% to 9.4% and from -5.7% to 5.7%. The intra-class correlation coefficient was higher than 0.75 between the weight-bearing distribution produced and that perceived during STS. The results contribute to extend knowledge about perception of force and weight bearing distribution in young and elderly healthy individuals. This data will be used for comparison in studies conducted with hemiparetic individuals in order to assess if the latter have perceptual problems which may explain the recurrent asymmetry they present in functional tasks.

Keyphrases: perception, force, weight-bearing distribution, static contraction, sit-to-stand, rehabilitation
Importance du stress oxydant dans le diabète secondaire à la fibrose kystique

Introduction: Cystic fibrosis (CF) is the most prevalent lethal genetic disorder affecting mostly lungs and the gastro-intestinal tract. CF is caused by mutations in the gene encoding the CFTR protein, a chloride channel expressed in organs with exocrine secretions. The main functions of the CFTR channel are the following: 1) regulation of electrolyte composition of secretions; 2) maintenance of fluid secretions and; 3) transport of glutathione. The CFTR protein dysfunction leads to thick and viscous secretions with obstructive phenomena responsible for fibrosis occurence in various organs. In the lungs, accumulation of the thick mucus reduces their capacity to eliminate inhaled bacteria responsible for repeated infections and pulmonary tissue damage through inflammatory processes. In the gastro-intestinal tract, the thicknened micus leads to nutritive elements and the major antioxidants malabsorption. Increased oxidative stress has been associated with the onset of diabetes and oxidative stress by-products have been involved in the pathogenesis of diabetic complications. Increased oxidative stress has also been shown in CF but the relationship between oxidative stress and the occurrence of CF-related diabetes (CFRD) remains unclear. Objectives: Our study aims to investigate the role of oxidative stress in the impaired glucose metabolism in CF patients and its relation with the altered glucose-stimulated insulin secretion process. We first determined the impact of lipid peroxidation on glucose tolerance and the antioxidant status in CF patients with altered glucose tolerance. Secondly, we evaluated the role of oxidative stress on insulin synthesis and secretion in the murine pancreatic β-cell line βTC-tet. Results: In CF patients, we demonstrated that conditions of glucose intolerance and diabetes are associated with increased lipid peroxidation as seen with increased blood levels of 4-hydroxynonenal bound to proteins (HNE-P). The antioxidant status evaluated with blood levels of glutathione showed a strong correlation between levels of oxidized glutathione and glucose intolerance. Acute exposure of βTC-tet to oxidative stress led to: 1) increased lipid peroxidation marker levels; 2) increased insulin release in basal conditions; 3) altered glucose-stimulated insulin secretion process and; 4) no effect on the insulin synthessis pathway. We also demonstrated that pancreatic βTC-tet cells can fight against oxidative stress by upregulating their glutathione synthesis whereas the presence of an exogenous antioxidant can restore their secretory function. Conclusion: Oxidative stress can induce β-cell dysfunction through many pathways: 1) it inhibits the glucose metabolism and its by-products which are required for insulin secretion, 2) it activates the signalling pathway involving the pro-inflammatory genes and; 3) it damages the cell structure by inducting the lipid peroxidation process.

Keyphrases: Oxidative stress, Cystic fibrosis, Diabetes
Représentations du sens lexical en lexicologie explicative et combinatoire : étude de trois formalisations spécifiques

This study explores the different formalisations of linguistic meaning as encountered in the Meaning-Text Theory (MST) framework. Its main interest is semantic representation, which is the most important representation in the modeling of the meaning of utterances and lexical units. This study has three objectives: first, describing three existing formalisations of semantic representation in the MST – semantic networks, lexicographical definitions, and BDéf definitions (definitions that are extremely formalized); second, identifying the discrepancies between these formalisations; finally, proposing modifications to these formalisations in order to reduce the disparities as much as possible.

Keyphrases: lexicographical definition, lexical semantic, semantic formalization, Explanatory combinatorial lexicology, semantic networks
Le motif du voile dans Sordidissimes de Pascal Quignard

The bases of our analysis of the veil in Pascal Quignard’s Sordidissimes are the three following paradigms : clothing and nudity, sordes and shroud, and canvas and gaze. Thematic analysis as elaborated by Jean-Pierre Richard and psychoanalysis will guide our interpretation of the relation of the veil to the body, death and arts. The purpose of this study is to demonstrate the constant movement of the veil. It is not static; the breeze that is the willpower of the self always moves the veil without ever tearing it off. What the veil is hiding or partially revealing is the origin of the fascination – bet it morbid or sexual.

Keyphrases: French Literature of the Twentieth Century, Quignard, Pascal, Veil, Sordide, Sordid, Psychoanalysis
La perception du prestige des occupations illicites par des délinquants : une perspective sur les capitaux criminels

Occupational prestige is a measure used in the sociology of profession as a determinant of social status. It is conceptualized on continuum, and organized in a hierarchy defined by income, authority, autonomy and qualifications. Using interviews with incarcerated offenders (n=138), this study assesses if this concept of prestige can be used in the context of unlawful occupations. The results suggest that criminal occupation domains are not homogeneous with regards to prestige. Some indicators which contribute to the explanation of lawful occupations’ prestige, such as income and qualifications, contribute to unlawful occupational prestige as well, contrarily to autonomy and authority. The criminal world possesses some particular features such as the difficulty to attain continuity. This continuity explains unlawful occupational prestige, but not the lawful one. Other indicators, like the criminal network and the presence of a mentor influence criminal incomes, but have no direct impact on unlawful occupational prestige. Structural equation modeling was used to observe indirect relationships and conversion rates between the different forms of capitals according to the Pierre Bourdieu’s social space theory. These analyses suggest the essentiality of the qualification and the continuity. The discussion and conclusion develop on the concepts of continuity, capital accumulation and conversion.

Keyphrases: criminologie, performance criminelle, capital social, criminology, occupational prestige, criminal achievement, social capital, qualification, social space theory
Réactions d’ouverture d’aziridines Troc-protégées

The main subject of this Master thesis is the ring-opening reactions of azirdines and their synthetic applications.  Our group has recently developed a copper-catalyzed enantioselective aziridination reaction from N-tosyloxycarbamates which leads to a variety of carbamate-protected arylaziridines. Although the aziridine motif appears in some natural products, interest in these models comes from the easy access to amine-protected derivatives obtained via the nucleophilic ring-opening of aziridines.  Nucleophilic ring-opening of aziridines has been thoroughly studied for a variety of nucleophiles and aziridines.  However, as carbamate-protected arylaziridines were not previously available, little is known on either their reactivity or regio- or stereoselectivity.  We present herein the results of the ring-opening of Troc-protected p-nitrophenylaziridines with a variety of nucleophiles.  Furthermore, following the discovery that excellent diastereoselectivities could be achieved by using the chiral derivative PhTrocNHOTs, ring-opening reactions were attempted on PhTroc-protected p-nitrophenylaziridine.  Optimized conditions were found to be 10 mol% of BF3∙OEt2 at room temperature with a variety of nucleophiles.  These conditions were also used in the ring-opening of various PhTroc-protected aziridines and the results are disclosed herein.  Finally, these conditions were applied to the synthesis of (R)-Nifenalol, a beta-blocking agent that has shown antianginal and antiarrhythmic properties as described in the third chapter.

Keyphrases: Aziridine, Troc, PhTroc, (R)-Nifenalol, Aziridine, aziridine ring-opening, Troc, PhTroc, (R)-Nifenalol
Pauvreté, criminalité et problèmes de santé mentale : une évaluation qualitative et quantitative des interventions communautaires et policières dans un taudis mal famé

Models of problem-oriented policing and community policing are often shown in opposition to each other. This thesis presents an evaluation of a police crackdown, combining elements of the above mentioned models and aimed at ending disorder outbreaks caused by tenants of a troublesome flophouse. Analyses are based on both qualitative and quantitative evaluations of community and police interventions conducted in a building known as the "Motel".  Results obtained through discussions with community organizations, police and neighbourhood residents have lead to better understanding the phases of this police and community operation. They also provided the operation mode on property buyback by a municipal administration and assessed its impact by means of a preventive perspective. The results also helped to acknowledge the importance of flophouses for a number of helpless tenants in this district, but also the reputation that follows. The management process for this category of building is in close correlation with the type of tenants who live there. A field analysis, conducted three years after the operation, has made it possible to identify the type of problems afflicting the majority of tenants living in flophouses that are privately managed. In this case, the problems are linked to mental health.  Results of the quantitative evaluation have demonstrated that intensive patrol surveillance increases residents’ propensity to place 9-1-1 calls and the strategy to reduce disorder in the general neighbourhood by targeting notorious slums has not been particularly conclusive on the site observed.

Keyphrases: Éviction, Appels 9-1-1, Eviction, Police raid, Mental health, Evaluation, 9-1-1 calls, Displacement, Property buyback
La responsabilité civile de l'industrie pharmaceutique : le risque de développement : étude comparative des droits brésilien et québécois

On the one hand, the scientific development in the pharmaceutical sector provides substantial benefits to human health, thus improving his quality of life. However, developing a new therapeutic substance is a hard task. The laboratories have been investing time and money in research and development to get there.  On the other hand, despite the benefits of science and the efforts of researchers, drugs are potentially dangerous. They pose risks inherent in their nature, can cause serious and irreversible damage. Moreover, the hazardous nature of these products has prompted the creation of standards that impose strict criteria for drug manufacturers in order to protect the public.  By following this global trend, the Brazilian and Canadian legislators have introduced statutory regulations that lay down strict rules of design, manufacture and marketing of drugs. However, as a result of criminal and administrative standards, they are not effective when it comes to compensate the victim of the drug. In this situation, we must resort to civil law, in the case of Brazil and Quebec, or the common law in respect of other Canadian provinces.  In a comparative study, we find out that civil law in Brazil and Quebec and Canadian common law have significant similarities, however, regarding the exclusion of liability based on the risk of scientific development, different solutions apply.

Keyphrases: Liability, pharmaceutical industry, statutory rules, civil law, development risk, Brazil, Quebec
Les manifestations orales de la maladie de Crohn chez les enfants et les adolescents

Oral manifestations of Crohn’s disease are well documented in adults. However, no studies have investigated the oral manifestations of this condition in children and adolescents. Regarding oral health, only a few studies have evaluated the prevalence of dental caries in these patients.  The objectives of this study are to describe the oral manifestations of Crohn’s disease in children and establish a link between the state of the disease (active and in remission) with the prevalence of dental caries and the cariogenicity of the diet of these children. Hypotheses • The oral manifestations described in adults are present in children and adolescents of the Ste-Justine group. • There are different oral manifestations in children. • Children with Crohn’s disease have more dental caries than children in good health. • The cariogenicity index of the diet is high in patients with Crohn’s disease • The state of the disease has an effect on the prevalence of the oral manifestations. Methodology  An ethic’s certification was obtained from Ste-Justine Hospital. Of 40 recruited patients, 21 patients (9 girls, 12 boys) ranging in age from 5.1 to 17.3 years of age participated in our transversal study.  A medical history, a complete oral exam,  a diet analysis  and a review of the medical chart gave us the opportunity to record the presence of oral manifestations, the prevalence of dental caries (DMFT) and the cariogenicity score (SPC).  The DMFT of Crohn’s disease patients was compared with the DMFT of Quebec children establish in the Dr. Brodeur epidemiological study conducted in 1996. The patients were also divided into two groups according to the state of the disease (active or remission) to evaluate if it affected the prevalence of oral lesions, the DMFT and the SPC. Results  The statistics show : • No significant difference between the DMFT of Crohn’s disease patients and the control group. • No oral manifestations other than those published in the  adult literature. • 57% of patients reported to have ulcers  at some time during the disease • The patient in the active phase is not different then those in remission ones regarding oral manifestations,  DMFT and SPC. • Children taking methotrexate have a higher DMFT • Patients with a higher DMFT do not necesserarily have a higher SPC Conclusion  The results of our study do not demonstrate any new oral manifestations in Crohn’s disease in children that have not already been described in adults. In addition,  children with Crohn’s disease do not seem to be at high risk for dental caries. Further studies are necessary on the oral manifestations of Crohn’s disease in the pediatric population.

Keyphrases: Crohn's disease, Oral manifestations, Dental caries
La plume et le glaive : Caligula et la création littéraire chez Camus

For Albert Camus, literature was both an activity crucial to his happiness and a study object. In order to understand what conception of literature can be found in Camus’ writings and the responsibilities of the writer that this definition implies, this memoir studies his two main essays, The Myth of Sisyphus and The Rebel, and one play, Caligula. Our first chapter consist in a research of what makes artistic creation an exceptional activity in the light of Camus’ thoughts on absurd on revolt. In our second chapter, the critics’ various commentaries about Caligula are examined. In spite of what is still the opinion of a majority of critics, the play is not the tale of an absurd emperor who would revolt against his destiny. Also, the theme of literary creation has not been sufficiently studied in that play, in which it plays a determinant role. Finally, the third chapter of this memoir presents our own analysis of the play. The confrontation of fiction and theory reveals a great similarity between the two aspects of Camus’ writings. However, the match is never perfect, and the study of the friction points allows us to shed light on one of the most obscure part of Camus’ essays: the ethic of the creator placed in a situation where he must kill or be killed.

Keyphrases: Twentieth century French literature, Albert Camus, Albert Camus, Literature and philosophy, Absurd, Revolt
La razón de los tontos : protagonismo de los grupos subalternos en la formación de una conciencia de unidad nacional en Latinoamérica

This dissertation represents a study of subaltern groups in Latin America focusing mainly on the study of the literary production that these groups inspired but also on the social, ideological and cultural tensions derived from their presence within a nation. These groups, which I identify methodologically as Subaltern Groups, appeared in the literary and political panorama in an uncommon way, originating more from their negativity in relation to the modern project of positivist institutionalization than through the distinct characteristics of their culture. Nevertheless, they went on to become the iconographical symbol of national identity in their respective countries. Although, by definition destined to be forgotten historically, they later became protagonists of the “guiding fictions” forming an awareness of national unity.  The texts chosen for review in this research project reveal, paradigmatically, the reality and modalities of existence of these communities, characterised by their negativity in relation to the norms of modern hegemonic thought within the socio-cultural and political space of Latin America. These texts reveal a deviation in the course of the countries’ historical-discursive evolution with regards to the vision that the new Nation-states’ ideological artisans wished to impose on these groups at the end of the 19th century. In this study, two paradigmatic examples are analysed: that of the Canudos community in Brazil presented in Da Cunha’s Os sertões and that of the gauchos in Argentina, as portrayed in José Hernández’.  The first part of this thesis gives a general outline of the historical and socio-political references corresponding to the ideologies that lead to the modernisation of Latin America. I also put forward critical concepts the analysis of subaltern groups. In the following chapters, I proceed with a close reading of the above-mentioned texts, while considering, at the same time, the necessity of this analysis, the inherent challenges related to the problems as well as the nature of the subject. In this context, the thesis also characterizes the place that subaltern groups hold in the literary representations of their own countries as well as the impact that have had on the development of their nation’s collective imaginary. By reflecting on the data generated by the analysis, the conclusion of this thesis addresses the epistemological and ideological consequences caused by the discursive regime of the Latin-American Nation-state.

Keyphrases: subaltern groups, nationalism, Os Sertões, Os Sertões, The war of the end of the world, Brazil, Argentina
L'adaptation des agriculteurs vivriers du Sénégal au changement climatique : cas de la communauté rurale de Sessène

Senegal is located in a sudano-sahelian region vulnerable to climate change that renders agriculture, the country's main activity, precarious. In fact, changing climate conditions, particularly since the late 1960s, have considerably weakened the agricultural sector, which is mostly subsistence and pluvial in nature. Because of the importance of the country’s subsistence agriculture, it is imperative to know how subsistence farmers in Senegal have changed or will change their practices in order to satisfy their nutritional requirements in the context of climate change and variability. This study was undertaken in the rural community of Sessène using a qualitative approach composed on interviews, participant observation and phenomenological analysis. The research revealed the general characteristics of the agrarian families and farms, demonstrated how farmers dealt with climate change in the recent past and how they envisage doing so in the next few years, all aimed at contributing to a discussion of their adaptive capacity. In response to the shortening of the rainy season, the decrease in rainfall, the increased frequency of extreme events and the impacts of these changes on the natural environment, subsistence farmers are adopting both technical and socio-economic measures.

Keyphrases: Climate change, Subsistence farming, Senegal, Qualitative approach