NCube/papyrus huggingface dataset:
La racialisation comme constitution de la différence : une ethnographie documentaire de la santé publique aux États-Unis

At present one can note an intensification of the usage of race in public health in the United States, an idea that is sometimes rejected because of its association with controversial practices. Races are viewed, in this context, as the product of racism, a technology of power of the modern State that consisted of fragmenting humanity to permit colonisations. Thus, race has been established within the discourse to mark difference, discourse that consists of a heterogeneous ensemble of apparatuses, institutions, scientific statements, norms and rules. Racism developed concomitantly with the affirmation of power over life aimed at ruling out bodies and populations through public health practices among others. This thesis is based on an ethnographic study of a corpus of public health documents in the United States from federal Government offices and a major public health journal published between 2001 and 2009.  This study analyzed the ways in which race is represented, produced as object of knowledge, and regulated by discursive practices in these documents. The results confirm that the discourse on race varies throughout time. Hence, results indicate the relative permanence of a racialized regime of representation that consists of identifying, situating and opposing subjects and groups based on standardized labels. This regime constitutes an ensemble of representational practices which, together with disciplinary techniques and the use of culture as an idea, lead to the characterization and formation of racialized objects and stereotypes.  Also, these operations that fabricate racialization, tend, together with medicalization and culturalization, to naturalize difference, reproduce the symbolic order, and constitute racial identities. On the other hand, racialization appears to be torn between a power over life and a power over death. Finally, this study suggests a post-racial alternative that envisages human group constitution as fluid and deterritorialized.

Keyphrases: Race, Discours, Postcolonialisme, Racialization, Race, Medicalization, Ethnography, Public health, Discourse, Power, Representation, Postcolonialism, United States
Caractérisation fonctionnelle de la GTPase Ran dans le cancer épithélial de l'ovaire

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Malignant  epithelial tumors can be divided into different classes reflecting the extent of the disease. Low malignant potential (LMP) tumors have a 5 years survival rate of 90-95%. For invasive cancers (TOVs), the survival rate drops dramatically to 35-40%. In the laboratory, we previously identified that Ran protein, a member of the Ras GTPase family, is highly expressed in high grade and high stage serous epithelial ovarian cancers, and that its over-expression is associated with a poor prognosis. Ran is known to contribute to both nucleocytoplasmic transport and cell cycle progression, but its role in ovarian cancer is not well defined. Using a lentivirus-based tetracycline inducible shRNA approach, we show that down-regulation of Ran expression in aggressive ovarian cancer cell lines drastically affects cellular proliferation by inducing a caspase-3 dependent apoptosis. Using a xenograft tumor assay, we demonstrate that depletion of Ran results in decreased tumorigenesis, and eventual tumor formation is associated with the selection of tumor cells able to re-express the Ran protein. These results suggest a critical role for Ran in ovarian cancer cell survival and tumorigenicity and suggest that this critical GTPase may be suitable as a therapeutic target.

Keyphrases: Ran GTPase, Epithelial ovarian cancer, Low malignant potential and invasive tumors, Ran GTPase, Apoptosis
Déficit familial de la LCAT au Québec : description d’une première mutation et contribution du génotype de l’APO E sur le phénotype lipoprotéique

Familial LCAT deficiency (FLD) is a disease characterized by a defect in the enzyme lecithin:cholesterol acyltransferase (LCAT) resulting in low HDL-C, premature corneal opacities, anaemia as well as proteinuria and renal failure. We have identified the first French Canadian kindred with familial LCAT deficiency. Two brothers, presenting classical signs of FLD, were shown to be homozygous for a novel LCAT mutation. This c.102delG mutation occurs at the codon for His35 and causes a frameshift that stops transcription at codon 61 abolishing LCAT enzymatic activity both in vivo and in vitro. It has a dramatic effect on the lipoprotein profile, with an important reduction of HDL-C in both heterozygotes (22%) and homozygotes (88%) and a significant decrease in LDL-C in heterozygotes (35%) as well as homozygotes (58%). Furthermore, the lipoprotein profile differs markedly between the two affected brothers who had different APOE genotypes. We propose that APOE could be an important modifier gene explaining heterogeneity in lipoprotein profiles observed among FLD patients. Our results suggest that a LCAT-/- genotype associated with an APOE  ε2 allele could be a novel mechanism leading to dysbetalipoproteinemia. Finally we have identified major differences in the HDL sub-populations of both subjects affected by FLD. The carrier of the APOE  ε2 allele presented a much higher proportion of immature HDL particles (discoid preβ) compared to his brother (77.9% vs. 31.0%).

Keyphrases: Mutation, 102delG, LCAT, FLD, HDL, LpX, APOE, Mutation, 102delG, LCAT, FLD, HDL, LpX, dysbetalipoproteinemia, APOE
Dynamique de recombinaison dans les puits quantiques InGaN/GaN

We study the radiative recombination of optically generated charges in thin (2 nm) InGaN quantum wells. We characterise the behaviour of the photoluminescence with varying experimental conditions such as temperature, energy and power of the excitation and externally applied voltage. These measurements show that emission comes from localised states. We also show that electric fields, natively present in these materials, do not have a dominating effect on charge carrier dynamics.  We have shown that the emission spectrum changes significantly and rapidly when the excitation power drops below a certain level. The emission has two phases of which we have measured the diagram. The phase of the emission depends on the power of the excitation, the temperature and the electric field. We propose that the low power phase is associated with an electrically charged state in the material.  Decay dynamics was then characterised. We find that the excitation repetition rate has an influence on the measured dynamics. We conclude that the dynamics are not stretched-exponential as it was originally thought. The dynamics are exponential at short time and follow a power law at long time. This byphasic character results from a single recombination process.   We have developped a three-level recombination model to describe experimental dynamics. It supposes the existence of localisation states where carriers can localise, independently or not. This means that the electron can be localised on the same state as the hole or on any other state. If we suppose that inter-state transitions occurs by a tunnel effect, one can determine the decay dynamics as a function of the localisation states' spatial distribution. Henceforth, we then show that radiative recombination in thin InGaN/GaN quantum wells is dominated by localisation and charge separation.

Keyphrases: InGaN, Photoluminescence, InGaN, Photoluminescence, Quantum well, Nitrides, Semiconductor, Time dynamics
Les effets de l'européanisation de la lutte contre la migration irrégulière sur les droits humains des migrants

In Europe, migration policies are designed to control the entry and residence of foreigners on the national territory. Since the establishment of a common market in the 1980s, the European Union is increasingly involved in the treatment of foreigners. Migration and asylum have become issues of shared jurisdiction between the Union and its members. Policies are dominantly focused on the fight against irregular migration, perceived not only as a challenge to territorial sovereignty, but also as a threat to the welfare state and as a security risk.   This research explores the Europeanization of migration and asylum policy and its impact on irregular migrants’ human rights. It is asserted that, as a process of construction, diffusion and institutionalization of norms, practices and shared convictions, the Europeanization enables States to limit the number of unwanted foreigners on their territory, including asylum seekers. It legitimizes and reinforces already existing preventive and deterrent measures against clandestine migrants. Common norms and cooperation mecanisms are established with a view to optimizing States’ control over irregular migrants. This process transforms the migration paradigm not only in member States, but also in accession countries as they become the gatekeepers of the European Union’s external borders.  The research maintains that these developments have a negative impact on clandestine migrants’ fundamental rights. The vulnerability of asylum seekers is exacerbated by their systematic association to economic migrants. A comparative analysis of the securitization of French, British and Turkish forced removal policies demonstrates how the Europeanization limits the foreigners’ rights and curbs their capacity to claim rights before tribunals.  It is necessary to strike a fair balance between the legitimate aim to ensure citizens’ welfare and security and the protection of irregular migrants’ rights. It is argued that this balance will only be achieved by allowing the judiciary to test over time the constitutionality of repressive measures as well as their compatibility with international obligations of human rights and refugee protection.

Keyphrases: Migration, Human rights, Migration, Irregular migrants, Europeanization, Forced return, European Union, United Kingdom, Turkey
Caractérisation de Cks1, régulateur du cycle cellulaire, dans le cancer épithélial de l'ovaire

Epithelial ovarian cancer is the most lethal gynecologic cancer with a five-year survival rate of only 30-40% in patients diagnosed with high-grade invasive disease (TOV). This contrasts with the 95% five-year survival in patients diagnosed with the low malignant potential (LMP)disease. Previously, we have identified differential expression of Cks1 between serous LMP and TOV tumors through gene expression analysis using Affymetrix HuFL DNA microarrays. Overexpression of this cell cycle regulator was observed in the TOV tumors, but not in the LMP samples. To study its role on the invasive potential of ovarian cancer cell lines, Cks1 was depleted in two tumoral invasive ovarian cancer cell lines established in our laboratory, TOV112D and TOV1946, using an inducible shRNA strategy. Then, tetracycline-inducible stable clones were derived and studied further. Comparisons between clones and controls have shown no Cks1-dependent effect on cellular growth, neither in migration capacity nor spheroid formation. Thus, we can conclude that Cks1 does not play a crucial role in the tested parameters for cancer progression, but further experiments could elucidate the biological differences observed between the two kinds of tumors studied.

Keyphrases: Cks1, Epithelial ovarian cancer, Differential expression, Low malignant potential tumor (LPM), Invasive tumor (TOV), Cks1, Cell cycle
Synthèse de brosses de polyélectrolytes par polymérisation initiée depuis une surface de mica et étude de leur réponse en fonction du pH et de la force ionique

Neutral polymer brushes of poly(tert-butyl acrylate) (PtBA) and polyelectrolyte brushes of poly(acrylic acid) (PAA) were chemically grafted on mica in order to study their conformation as a function of grafting density, pH and ionic strength. The brushes were prepared via surface-initiated atom-transfer radical polymerization (SI-ATRP). This approach allows the control of the polymer growth and of the polymer grafting density. The study of brush conformation was investigated by measuring the dry and the swollen film thicknesses by Atomic Force microscopy (AFM) under various environmental conditions.  Mica substrates were activated by a plasma method leading to OH-functionalized surfaces to which a radical initiator was covalently bound using standard siloxane protocols. The initiator grafting on the mica substrate was confirmed by water contact angle measurements and time-of-flight secondary ion mass spectrometry (TOF-SIMS). The covalently immobilized initiator successfully underwent SI-ATRP with tert-butyl acrylate, yielding end-grafted PtBA brushes that are covalently linked to mica. A linear relationship of the polymer thickness with respect to the molecular weight of the free polymer and with respect to the monomer conversion is obtained confirming that SI-ATRP is well controlled. The PtBA brushes were then hydrolyzed to PAA as confirmed by water contact angle measurements, polymer thickness measurements and FT-IR. The grafted layers show a good stability in air, organic solvent and aqueous solution and a reversible swelling. Film cleavage is observed for long exposure time in basic solution. This study represents the first example of chemically grafted brushes on mica via SI-ATRP.  The polymer grafting density of poly(tert-butyl acrylate) was controlled by tuning the initiator surface coverage. By adjusting parameters such as the immobilization reaction time and concentration of the initiator, a wide range of initiator surface coverages and hence polymer densities on mica were possible ranging from 0.04 chain/nm2 to 0.5 chain/nm2).  The swelling behavior of PAA brushes was investigated as a function of the polymer grafting density, pH and ionic strength cs (NaCl). A sharp transition from collapsed to stretched conformation was found with increasing pH. At neutral pH, the brushes are collapsed and behave like neutral brushes in poor solvent. At high pH, the brushes are swollen and charged and belong to the Pincus regime. In the presence of salt, the Coulombic repulsions are screened. The observed behavior of PAA brushes resembles the one of strong polyelectrolyte brushes. This study contributes to a better understanding of the complex behaviour of weak polyelectrolyte brushes and brings experimental support to theoretical studies.

Keyphrases: ATRP, Mica, Conformation, AFM, Graft from, Surface-initiated polymerization, Polymer brush, Poly(acrylic acid), Grafting density, Stability
Régulations homéostatiques cardiovasculaires suite à une transfusion par échange avec du sang hyperagrégeant chez le rat

The aim of this study was to evaluate the effects of an acute change in erythrocyte aggregation on cardiovascular parameters by exchanging one third of the blood volume with hyperaggregating blood in the Brown Norway rat model. Values of caudal pressure, systolic cardiac volume, ejection fraction, cardiac output, heart rate and peripheral resistance to blood flow were observed non-invasively over 19 days after transfusion. The rats were sacrificed after more than a month following the procedure and an ex vivo study in response to pharmacological agents (acetylcholine and sodium nitroprussiate) was performed on mesenteric arterioles. Variations in cardiac output, systolic volume and peripheral resistance were noted for the first three days post-transfusion. The vascular smooth muscles of rats transfused with the hyperaggregating erythrocytes seemed to have developed a resistance to nitric oxide but no endothelial dysfunction was observed in response to acetylcholine.

Keyphrases: transfusion, erythrocyte aggregation, cardiac function, vascular function, endothelial function, hemorheology, blood viscosity, mean arterial pressure, cardiac
L'Institut économique de Montréal, un Think Tank influent sur la scène des idées au Québec

Since the election of Jean Charest in 2003, we notice that the neoliberal’s ideas (deregulation, privatization, liberalization, and reduction of government expenditures) have regularly inundated all public exchange of ideas in Quebec, from elected politicians to media conglomerates.  The author tried to determine how conservative ideas became part of the public discourse in Quebec. Our research lead us to a Quebec think tank: Montreal Economic Institute. The managers of this organization used its important influence with written media, particularly Gesca. Thanks to its large, powerful social network and its influence strategy, the Montreal Economic Institute think tank was able to transmit its neoliberal ideas.  In this way, this think tank has spread these ideas in the pages of the most read Quebecois daily newspapers.  Young think tanks, such as Montreal Economic Institute, believe that access to the media is essential to shape public opinion and public policy. Their purpose is to influence the setting of the agenda and the framing of discourse in the media to favor the respective think tank’s propositions and ideas.   The author analyzed three different cases, at three different times, in which she demonstrates that the Montreal Economic Institute has influenced the agenda setting of Gesca, and that the framing was largely favorable to the Montreal Economic Institute’s propositions.

Keyphrases: Think Tank, Propagande, Gesca, Montreal Economic Institute, Neoliberalism, Social Influence Network, Framing, Agenda Setting, Propaganda, Think Tank, Gesca
Synthèse formelle de l’hormaomycine et de la bélactosine A par utilisation d’une réaction de cyclopropanation intramoléculaire catalysée par un complexe de rhodium (II)

This master’s thesis presents three different approaches toward the synthesis of 3–(trans–2–nitrocyclopropyl)alanine, a key constituent of the natural product hormaomycin. This unusual compound demonstrates interesting biological and pharmaceutical activity. It is noteworthy that this unique amino acid can be readily converted to the corresponding 3–(trans–2–aminocyclopropyl)alanine, the central core of belactosin A, a natural compound exhibiting interesting biological properties. Efficient syntheses of these aminocyclopropane derivatives are of current interest since several structure-activity relationships in syntheses of belactosin A and hormaomycin analogues are currently under study in an effort to discover enhanced biological activity. A methodology developed in our research group based on a diastereoselective intramolecular cyclopropanation reaction will be used to elaborate a unique and elegant pathway to the synthesis of the 3–(trans–2–nitrocyclopropyl)alanine.  By using a rhodium carbene generated either by the degradation of a diazoic derivative or by the formation of the corresponding iodonium ylide, a diastereoselective cyclopropanation reaction can be applied in the concerted elaboration of two chiral centers needed in the desired aminocyclopropanes, avoiding in this way the utilisation of chiral reagents. Following this key sequence, an intramolecular rearrangement followed by synchronous ring–opening/decarboxylation reactions will permit a convenient formation of the desired product in an acceptable overall yield and in few ensuing steps. In this manner, the formal synthesis of the hormaomycin and the belactosin A can be achieved. This synthesis is unique since it involves only one asymmetric step in the whole synthetic process.

Keyphrases: 3–(trans–2–aminocyclopropyl)alanine, 3–(trans–2–nitrocyclopropyl)alanine, diazoester, hormaomycin, belactosin A, 3–(trans–2–aminocyclopropyl)alanine, 3–(trans–2–nitrocyclopropyl)alanine, diastereoselective intramolecular cyclopropanation reaction, intramolecular rearrangement, formal synthesis, diazoester, aminocyclopropane
Les recueils de correspondances des poilus, vers une mémoire collective française de la Grande Guerre

My research aims to address the phenomenon of the publication of the “poilus” correspondences (French soldiers of the First World War) and to determine their role in the collective memory of the Great War. Preceded by a historiographic review, my work is divided into three chapters around three main themes, correspondences, publishing and memory. The first chapter puts into context the production of letters and identifies the factors influencing it. The second chapter considers the leading goals of publishing correspondences and their transformation over time. Finally, the last chapter analyzes the need for these publications for commemoration of the Great War. Research goes beyond the analysis of letters and focuses on the leading intentions of the editions. The sources used are anthologies of the “poilus” letters, published between 1922 (La dernière lettre) and 2006 (Paroles de Verdun).

Keyphrases: First World War, Correspondence, Publishing, Memory, Commemoration
Approches algorithmiques pour l’inférence d’histoires de duplication en tandem
avec inversions et délétions pour des familles multigéniques

[English] Tandemly arrayed genes (TAGs) represent an important fraction of most genomes. A fundamental mechanism at the origin of TAG clusters is unequal crossing-over during meiosis, leading to the duplication of chromosomal segments containing one or many adjacent genes. Such duplications are called tandem duplications, as the duplicated segment is placed next to the original one on the chromosome. Different algorithms have been proposed to infer the tandem duplication history of a TAG cluster. However, their applicability is limited in practice since they do not take into account other frequent evolutionary events such as inversion, inverted duplication and deletion. In this thesis, we propose different algorithmic approaches allowing to integrate these evolutionary events in the original tandem duplication model of evolution. Our contributions are summarized as follows: • We integrate inversion events in a tandem duplication model restricted to single gene duplications, and we propose an exact algorithm allowing to compute the minimum number of inversions explaining the evolution of a TAG cluster. • We generalize this model to the study of orthologous TAG clusters in different species. • We propose an algorithm allowing to infer the evolutionary history of a TAG cluster through tandem duplication, inverted duplication, inversion and deletion of chromosomal segments containing one or many adjacent genes.

Keyphrases: duplication tree, gene tree, inverted duplication, gene family, median, gene loss, genomic rearrangement, reconciliation
Les notions de possession et d'exorcisme en Grèce ancienne à la lumière des auteurs anciens, des phylactères et des PGM

The notion of an alien and invisible spirit who takes possession of a person is believed to be Semitic. The Near East and Jewish people had developed rituals and specific practices to get rid of them. The Greeks, meanwhile, had to deal with numbers of entities, daimones, dead or apparitions and sometimes with the gods themselves, whose actions could be very harmful, if not clearly invasive. Nevertheless, the communis opinio holds that the concepts of possession and exorcism where belatedly introduced, and this only under the influence of Semitics. However the literature and the epigraphic, archaeological and papyrological sources seems to show that the Greeks already had, from the classical period, in their own culture and religion, the characteristic elements of possession and exorcism. A detailed analysis of some ancient texts, of magical formularies, including the well-known Greek Magical Papyri, and of various amulets, provides decisive arguments in this direction.

Keyphrases: Magic, Possession, Exorcism, PGM, Literature, Tragedy, Amulets, Vocabulary, Disease, Demons