NCube/papyrus huggingface dataset:
Changements et évolution des universités conventionnelles sous l’influence des technologies de l’information et de la communication (TIC): le cas du contexte universitaire nord-américain

This research is regarding the increasing use of Information and Communication Technology (ICT) in Higher Education, within conventional universities as well as open and distance education, and focuses on its institutional, educational and technological implications for campus-based and distance programs. The research was undertaken throughout fifteen Canadian universities in which twenty-four directors and experts, working in teaching and learning centres, were interviewed.              For the institutional aspect, the research relied on the Kershaw & Safford's Open System Communications Net (1998, 2001) theoretical framework that considers the universities' structural and function change in the digital era. The research results confirm that conventional universities are in a period of transformation due to the use of digital technologies; and, that blended learning courses, bimodality, virtual universities, universities using diverse models and universities operating with artificial intelligence, will be the models with high-growth probability during the next decades in North America.              Regarding the educational aspect, the research used a theoretical perspective pertaining to Garrison, Anderson & Archer Community of Inquiry Framework (2000) reviewed by Vaughan & Garrison (2005) and Garrison & Arbaugh (2007) that advocates a cultural change in University work, based on three levels of presence. The research results indicate the importance of elements related to teaching presence, cognitive presence and social presence, as the model suggests. However, the recurrence- at the three levels of presence- of some indicators the interviewees mentioned led to conclude that the CoI model has some interchangeable indicators within its categories. Furthermore, some categories frequently mentioned by the respondents should require a greater consideration. That is the case of the “Group Cohesion” category.              Finally, with respect to the technology employed, the theoretical framework used Olapiriyakul & Scher's Content Design and Development Model (2006) that postulates that the technological infrastructure for university teaching must be both instructional technology and student learning technology. The research results reveal that educational reasons are not necessarily the ones for which universities make the decision to apply ICT to teaching; and, because of that, the technology used may not have been chosen for its learning benefits. This observation led to the interviewees describing opportunities for the development of the next generation of learning technologies applicable to conventional universities.

Keyphrases: Information and Communication Technologies, E-learning, Open and Distance Learning, Blended Learning, Virtual Universities, Bimodal Universities, Conventional Universities, Canadian universities, Changes, Evolution
Syndrome inflammatoire chez les schizophrènes toxicomanes

Schizophrenia is a psychosis which presents a frequent comorbidity with substance use disorders (SUD) and with various immune alterations. Using meta-analysis, we have demonstrated previously establishment of an inflammatory syndrome in schizophrenia patients, illustrated by elevated circulating levels of IL-6 (a pro-inflammatory cytokine), sIL-2R (marker of immune activation) and IL-1RA (an anti-inflammatory cytokine). SUD is also associated with dysregulation of inflammatory cytokines, but the effects may depend on the type of substance of abuse. The goal of this project was: 1) To measure plasma concentrations of inflammatory cytokines in schizophrenia patients with comorbid SUD, before, during and after treatment with an atypical antipsychotic, quetiapine; and 2) To perform correlation studies between plasma concentrations of inflammatory cytokines and clinical symptoms, including positive and negative symptoms, cognition, depression and substance use. Relative to normal controls, patients with a dual diagnosis showed increased plasma concentrations of IL-6, IL-1RA, sIL-2R, and IL-8 at baseline, IL-1RA increases being the most important. Quetiapine treatment did not influence plasma cytokine concentrations, except sIL-2R which increased further. Moderate positive correlations were found between IL-6 and depression, IL-6 and alcohol, IL-1RA and cognition, IL-8 and depression, IL-8 and alcohol and between sIL-2R and cannabis. This study demonstrates that the immune and inflammatory response is activated in schizophrenia patients with comorbid SUD. Furthermore, SUD may play a facilitating or potentiating role in the increases in peripheral levels of IL-1RA. Ongoing studies in different patient populations with schizophrenia with or without SUD, and patients with SUD alone will help elucidate the role of different substances of abuse in the inflammatory syndrome in schizophrenia, as well as the clinical and therapeutic relevance of this syndrome.

Keyphrases: IL-6, IL-1RA, sIL-2R, IL-8, IL-17, Schizophrenia, Drug addiction, Quetiapine, clinical Symptoms, Cognition and Depression
Régulation de protéine C-réactive vasculaire dans le diabète de type 2

Atherosclerotic cardiovascular disease is the leading cause of death in western countries and the major complication of metabolic syndrome. It is now widely accepted that atherosclerosis is a chronic inflammatory disease and that inflammation plays a major pathogenic role in the initiation and progression of atherosclerotic disease. It has been demonstrated that increased serum levels of C-reactive protein (CRP), a protein of the acute phase and a major constituent of the innate immune response, is associated with increased cardiovascular risk and that, in both healthy subjects and diabetic patients, high CRP enhances the risk of cardiovascular morbidity and mortality. Several evidences suggest that CRP may not only be a cardiovascular risk marker but may also represent a direct pro-atherogenic factor. Endothelial dysfunction is a characteristic feature of early-state atherosclerosis and a role of CRP in the pathogenesis of endothelial dysfunction has been proposed. In addition to its systemic origin, CRP is produced in atherosclerotic lesions and by various vascular cells, including endothelial cells. To elucidate the role of CRP in endothelial dysfunction associated with the metabolic syndrome, we studied the regulation of endothelial CRP expression by free fatty acids (FFA) and the role of endothelial CRP as mediator of the inhibitory effect of FFA on nitric oxide (NO) production. Our results demonstrated that: 1) Palmitic acid (PA) induced CRP gene expression in cultured human arterial endothelial cells (HAECs) and increased CRP protein expression in a dose-dependent manner; 2) Pretreatment of HAECs with antioxidants and inhibitors of i) protein kinase C (PKC), ii) nuclear factor-kappa B, iii) Janus kinase and signal transducer and activator of transcription and iv) mitogen-activated protein kinases prevented the stimulatory effect of PA on CRP protein and gene expression; 3) Treatment of HAECs by PA led to an increased production of reactive oxygen species, an effect prevented by PKC inhibitors and by AICAR (5-amino-4-imidazole carboxamide 1-β-D-ribofuranoside), an AMP-  activated protein kinase activator; 4) Decreased production of NO was finally observed in PA-treated HAECs, an effect prevented by preincubating endothelial cells with an anti-CRP.  Overall, these data indicate a stimulatory effect of PA on endothelial CRP expression through the activation of oxidative stress-sensitive kinases and transcription factors. They further suggest a role of CRP in FFA-induced endothelial dysfunction.

Keyphrases: PA, inflammation, CRP, Metabolic syndrome, insulin resistance, oxidative stress, PA, atherosclerosis, cardiovascular diseases, endothelial cells, inflammation, C-reactive protein, type 2 diabetes
L’influence du développement durable à travers la formation universitaire
en design industriel

Today, the experience accumulated in the field of environmental design has put into perspective that approximately 75 to 80% of the environmental impacts of a product are determined during the design process. The role of the industrial designer is therefore crucial for achieving a better management of environmental impacts. In Quebec, the university curriculum in product design does not address sustainable development in a comprehensive manner; the introduction of this paradigm remains weak. This research seeks to target those areas of knowledge that should be part of the curriculum for training professionals in product development for environmental design. As a first step, we studied the curriculum of academic programs that "specialize" in environmental and sustainable development in Quebec, and then, the training programs in eco-design available in France. The field work was completed with an in-depth interview with a Quebec speaker who focuses on addressing environmental aspects in product development for enterprises. The information collected during these three phases of the field study was analyzed and highlighted the need for a major transformation of the university curriculum regarding the ways in which the environmental issues are addressed in industrial design as to: 1. Introduce the knowledge related to environmental issues; 2. Promote multidisciplinary team work; 3. Create collaboration between schools and industries for a better understanding of design processes (business culture, economic aspects, schedule, laws, etc.).

Keyphrases: Ecodesign, Sustainable development, Design durable, Sustainable design, Pedagogy, Industrial design
La défense et l'organisation militaire des Gaules de 284 au repli sur Arles des services administratifs romains au début du Ve siècle

The army stationed in Gaul during the Later Empire was one of the three main armies available to the Roman Empire. Its evolution from the late IIIrd century to the early Vth century was marked by reforms applied gradually to the high command, and to the organization of troops and fortifications. These measures have interested scholars who established a model of troop deployment which enjoyed great popularity over a long period of time. The idea of strategy applied on a great scale was later included in this concept. This thesis proposes a synthesis of the latest research on the late Roman army in Gaul. The selected approach of analysis is based on a reevaluation of the sources without the bias of a preconceived defensive model. Some obsolete ideas regarding the late Roman army will also be subject to criticism.

Keyphrases: Roman army, Late Antiquity, Barbarians, Comitatenses, Comitatenses, Limitanei, Limitanei, Diocletian, Constantin, Constantine, Julian, Valentinian, Gaul
Implication des biofilms dans la rhinosinusite chronique et l’évaluation des traitements avec un modèle in vitro

Introduction: The role of biofilms in chronic diseases is increasingly recognized. Chronic rhinosinusitis, with its chronic indolent course, resistance to antibiotics, and acute exacerbations, has an evolution that parallels that of other biofilm-related diseases. Objectives: 1-To develop an in vitro method to assess the biofilm formation capacity. 2- To determine whether biofilm-forming capacity of bacteria demonstrated in chronic rhinosinusitis has an impact on persistence of the disease following endoscopic sinus surgery. 3- To determine the in vitro activity of moxifloxacin against Staphyylococcus aureus in biofilm form. Method: Thirty-one bacterial strains recovered from 19 patients with chronic rhinosinusitis at least one year post-endoscopic sinus surgery. Evolution of disease was assessed by questionnaire and endoscopy as favorable or unfavorable. The bacteria were cultured on a 96-well culture plaque and a semi-quantitative method using crystal violet to quantify biofilm production was used. Confirmation of the effect of the antimicrobial agents on viability was performed with confocal laser microscopy, using a LIVE/DEAD BacLight staining. Results: Twenty-two of 31 samples produced a biofilm thicker or equal to the positive control. Biofilm formation was associated with a poor evolution for Pseudomonas aeruginosa and Staphylococcus aureus, but not for coagulase-negative staphylococci. Biofilm treated with moxifloxacin at 1000X (0.1mg/ml – 0.2 mg/ml) gave a 2 to 2.5 log reduction in number of viable bacteria. Conclusion: We have shown that Crystal violet method is able to detect biofilm formation. There is a correlation between in vitro biofilm production by Pseudomonas aeruginosa and Staphylococcus aureus and unfavorable evolution after endoscopic sinus surgery, suggesting a role for biofilm in chronic rhinosinusitis. Increased concentrations of moxifloxacin, easily attainable in topical solutions have a potential role in the management of biofilm infections.

Keyphrases: Biofilm, Pseudomonas aeruginosa, Staphyloccocus aureus, LIVE/DEAD BacLight, concentration minimal inhibitrice, chronic rhinosinusitis, endoscopic sinus surgery, confocal laser scanning microscopy, moxifloxacin, minimal inhibitory concentration
Savoirs experts et idiome quotidien. Biens et vertus de la conception participative des velos de quartiers à Trois-Rivières

This paper analyzes the development of a public bike system initiated by a civic organization that treats participation as a core principle. The analysis shows that the satisfaction of the goals pursued through the adoption of participative principles, amongst which the respect of citizens' personal experiences in the design of their world, is a difficult task. The near identity between the system designed with the help of citizens and other systems offered by large industrial companies cast doubt on the capacity of the participative principles to produce outputs that would represent genuine alternatives to careless design. The difficulty stems from the willingness to take participatory procedures as necessary conditions to the realization of democratic ideals in modern liberal societies. Putting forward principles for their own sake drives us away from the ideals of liberal democracy that promote efficiency in the actions we adopt, over and above sole obedience to a common practice.

Keyphrases: participation
El Sur como espacio identitario en Torres García, Borges y Solanas

This study conceptualizes the symbolism of the South as an identity space built by a political ideology and a local aesthetics. The Uruguay artist Joaquín Torres García’s inverted maps (1936, 1943) are a political stand that asserts the enunciative power of Latin American artists who create independently of the European cultural centers. His theory of “Constructive Universalism" proposes a new art for Latin America, for the South, and originating in the South, by combining pre-Colombian artistic ethics and modernist abstraction. In the short story "The South" (1953) and the essay "The Argentine writer and the tradition" (1951), the Argentine writer Jorge Luis Borges redefines South American literature, marginalized and peripheral, as a literature that is entitled to all aspects of the Western culture. By doing so, he rejects a culture that would only be nationalist. We analyze Argentine filmmaker Fernando Solanas’ cinematic diptych, which includes the films South (1985) and Tangos, the Exile of Gardel (1988) in dialogue with the manifesto "Towards a Thrid Cinema" (1969), co-written with Octavio Getino. The South is seen as a space for the denunciation of the censorships imposed by the dictatorship and imperialism, but also as a space for the renovation of culture and identity. In the two movies, Solanas uses a regional cultural product, the tango, as tool of political denunciation. Throughout the study, we use Michel Foucault's notion of “heterotopia” and Walter Mignolo’s concept of the “moveable center” to explore South’s multiple meanings.

Keyphrases: Tango, Symbolism of the South, Imperialism, Neocolonialism, Artistic ethics, Argentine dictatorship, Tango, Pre-Colombian art, Modern art, Moveable center, Heterotopia
Approches transcriptomiques dans l’étude de la fibrose kystique

Biotechnical advances have allowed a large number of molecular mechanisms to be identified, and have also underlined the complexity of gene regulation. Nonetheless, we still only have a partial understanding of cellular homeostasis. Even with our current knowledge, molecular dysfunctionality observed in genetic illnesses such as cystic fibrosis remain largely misunderstood, prohibiting us from developing efficient treatments. Cystic fibrosis is caused by a mutation of the CFTR (cystic fibrosis transmembrane conductance regulator) gene which codes for a chloric transmembrane channel. The most frequent mutation (ΔF508) causes the unfolding of the protein and its retention in the endoplasmic reticulum. This absence of a functional CFTR to the membrane has an impact on the ionic homeostasis and the hydration of the respiratory mucus. Consequently, the mucociliary clearance is disrupted, which leads to chronic infection and excessive inflammation - two fundamental factors of CF’s physiopathology. Inflammation plays a key role in the evolution of the illness and despite many studies on this subject, the regulation of the inflammatory process remains a mystery and CFTR’s role is not well established. Additionally, since the physiopathology cannot be explained by mutation alone, several authors suggest the importance of other factors (genetic and/or environmental) which are factors in the clinical picture of the illness. In our study, we use microarray technology to evaluate the transcriptional state of an epithelial lung cell issued from a human with cystic fibrosis. Initially, our analysis identifies 128 inflammatory genes which are over-expressed in the cystic fibrosis cells versus non-cystic fibrosis cells, showing several inflammatory gene families such as cytokines or calgranulins. An analysis of the publications and annotations of these transcripts suggests that their modulations depend upon the cascade of NF-κB and/or signalling pathways associated with interferons (IFN). In other words, their modulations could be associated with epigenetic modifications of their chromosomal loci. Secondly, we study the transcriptional activity of an epithelial lung cell issued from a human with cystic fibrosis in the presence of DMNQ, a cytotoxic molecule. Our goal is to identify the biological processus which are disturbed by the mutation of the CFTR gene in the presence of oxidative stress. Based on a canonical redundancy analysis, we identify 60 genes associated with cell death and their modulation in our study explained by the combined effect of mutation and oxidative stress. By measuring the activity of caspase 3/7, an effector of apoptosis (programmed cell death), we see that the cells containing the mutation ΔF508 could present a problem with apoptosis. Our transcriptomic data suggest that decreased activity of the MAPK cascade and over-expression of anti-apoptotic genes would be a factor in apoptotic imbalance.

Keyphrases: ΔF508, inflammation, Cystic fibrosis, microarray, inflammation, apoptosis, canonical redundancy analysis
Corrélats neuronaux de l'expertise auditive

The human voice is the most meaningful sound category of our auditory environment. Not only is the human voice the carrier of speech, but it is also used to extract a wealth of relevant information on the speaker. Voice-sensitive areas have been identified along the superior temporal sulci of normal adult listeners. Yet little data is available on the nature and development of this selective response to voice. In the visual domain, a vast literature focuses on a similar problem regarding face perception. Several studies have identified processes and regions involved in visual expertise, demonstrating a strong resemblance to those used for faces.  In the auditory domain, very few studies have compared voice expertise to expertise for other sound categories. Such comparisons could contribute to a better understanding of voice perception and hearing. This thesis aims to clarify the nature of the processes and regions involved in voice perception. Different types of experts and different experimental methods were used in three separate studies.  The first study assessed the influence of musical expertise on timbre voice processing, by using using behavioral voice and musical instrument discrimination tasks. The results showed that amateur musicians performed better than non-musicians in both tasks, suggesting a generalization of auditory abilities associated with musical practice. The second study compared event related potentials evoked by birdsongs in bird experts and non-expert participants. Because a different topographical distribution was observed among bird experts in all sound categories, a definitive interpretation was difficult to make.  In the third study, we asked whether the voice-sensitive areas would be recruited by different categories of sounds of expertise in guitar makers, bird experts and non-experts. The behavioral data showed an interaction between the two groups of experts and their respective category of expertise for memory and discrimination tasks. The functional magnetic resonance imaging results showed an interaction of the same type in the left superior temporal sulcus and the left posterior cingulate gyrus. The results show that the voice selective areas do not exclusively process voice stimuli but could also contribute to expert-level processing of other sound categories. Therefore, cortical selectivity to human voice could be due to a prolonged exposure to voice.  The data presented demonstrate several behavioral and anatomo-functional similarities between cerebral voice processing and other types of auditory expertise. These common aspects can be explained by a functional and economical brain organization. Consequently, sound processing would rely on shared neural networks unless necessary. This interpretation is particularly important to suggest an integrative approach for studying voice processing specificity.

Keyphrases: Expertise, Audition, Timbre, Voice, Expertise, Audition, Musicians, Timbre, Neuroimaging