NCube/papyrus huggingface dataset:
Initiatives médiatiques pour baliser le développement des nanotechnologies : une enquête qualitative auprès des journalistes et des chercheurs en nanobiotechnologies

Thanks to nanotechnologies, mankind can control matter at the nanometer scale, on the level of individual atoms and molecules. Materials obtained following these nanoscale manipulations demonstrate novel properties with the potential for application to all scientific and technological disciplines. Nanotechnologies are therefore often considered a foundation for a deep technological and social revolution. However, while nanotechnologies interest investors, government, private enterprises and universities, they also raise ethical questions, particularly regarding their toxicity, their outcome and the modification of human beings. On top of these ethical questions several other interrogations arise with respect to the governance of nanotechnologies: how, indeed, should their development be initially monitored in order to avoid eventual negative consequences in the future? Among these many questions, the role of the media in the relations between the developers of nanotechnologies and the public is often mentioned. Some see in the media an actor that researchers might refer to in order to establish a dialogue with the public to insure a harmonious development of nanotechnologies. While this recommendation seems very relevant, no empirical study exists to our knowledge to assess its feasibility among the concerned stakeholders (researchers, media). Within the scope of this thesis, we thus wanted to examine and analyze the perception of researchers and journalists from Quebec towards media initiatives to monitor the development of nanotechnologies. To do so, we proceeded to perform a qualitative study with twenty (20) researchers in the fields of nanobiotechnology/nanomedicine and ten (10) journalists specialized in scientific popularization. The analysis of interviews with responders revealed that while the concerned parties are in favour of these initiatives, there are several constraints that may impede such an enterprise.  Following the study of these constraints, we have suggested concrete initiatives that Quebec researchers may implement in order to better monitor the development of nanotechnologies through a dialogue with the public. These suggestions mainly consist in creating private media for researchers, resorting to independent media and engaging the World Wide Web. Such initiatives, however, can only be obtained at the price of a realignment of researchers’ priorities.

Keyphrases: Bioethics, Researcher, Media Ethics, Journalist, Media, Nanoethics, Nanotechnologie, Nanotechnology, Nanobiotechnology, Nanomedicine, Nanoscience
Évaluation d’une intervention infirmière basée sur une approche caring et cognitive comportementale sur l’acceptation d’un défibrillateur cardiaque implantable

Patients with an implantable cardiac defibrillator (ICD) decrease their risk of mortality related to life threatening arrhythmias. However, multiple concerns about this device exist, including ICD shocks, which may result in increased anxiety and a perceived limitation in performing everyday activities. These emotional reactions and behavioral changes may have a negative impact on the acceptance of the device. The purpose of this randomized pilot study with a group control (n=15 / group), was to verify the feasibility and acceptability of an individualized nursing intervention aiming to decrease anxiety, improve performance in everyday activities and device acceptance in patients with newly implanted ICDs. Based on Human Caring theory and a cognitive behavioral approach, this intervention addressed each patient’s unique concerns. From the identified concerns, the nurse intervened focussing on the patient’s dysfunctional beliefs that can lead to anxiety and avoidance behavior. After randomization, the first encounter for the experimental group (EG) was face-to-face before hospital discharge. Subsequently, two encounters were made via telephone, 7 and 14 days after discharge. The results support the feasibility and acceptability of the study design and the intervention evaluated. In addition, they emphasize the potential of the intervention to reduce symptoms of anxiety among the participants of the EG. The results of this pilot study may provide directions for future research and help guide clinical practice.

Keyphrases: Implantable cardioverter defibrillator, Pilot study, Nursing intervention, Device acceptance, Anxiety
Polyamides and polyesters made of bile acids in the main chain

Bile acids have drawn attention in the synthesis of polymers for biomedical and pharmaceutical applications due to their natural origin. The objective of this work is to synthesize main-chain bile acid-based polymers. The step-growth polymerization was used to prepare two important classes of polymers used in textile fibers, polyamides and polyesters. Heterofunctional bile acid-based monomers were synthesized and used in order to overcome stoichiometric imbalances during step-growth polymerization. The lithocholic acid derivative bearing amine and protected carboxylic functional groups was polymerized in bulk at high temperatures, yielding polyamides that were poorly soluble in common organic solvents. Soluble triazole-linked polyamides and polyesters were obtained when the cholic acid derivative bearing azide and alkyne functional groups was polymerized under mild conditions via copper(Ι)-catalyzed azide-alkyne cycloaddition. Two different catalytic systems, copper(Ι) bromide and copper(ΙΙ) sulfate, were tested. Only copper(Ι) bromide proved to be an effective catalyst for the system, allowing the synthesis of the polymers with a degree of polymerization of ca. 50 and an unimodal molecular weight distribution(PDI ˂ 1.7). The main-chain cholic acid-based polymers are thermally stable (307 °C ≤ Td ≤ 372 °C) with high glass transition temperatures (137 °C ≤ Tg ≤ 167 °C) and Young’s moduli in excess of 280 MPa, depending on the chemical structure of the linker.

Keyphrases: Bile acids, Polycondensation, Azide-alkyne cycloaddition, Polyamides, Polyesters
Un nouvel acteur dans la résolution des conflits : le Procureur de la Cour pénale internationale

The thesis aims to determine how international justice can contribute to peace-building and ending conflicts and more specifically whether the powers given to the International Criminal Court Prosecutor, in the Rome Statute, enable him to take action on ongoing conflicts.  The first chapter describes the events that led to the adoption of the Rome Statute in 1998 and explains the evolution from a post-conflict justice to a justice for peace. The Peace and Justice debate is further analysed as to demonstrate that the International Criminal Court Prosecutor may have an impact on ongoing conflicts if granted with prosecutorial discretion.  The second chapter looks into prosecutorial discretion in the Rome Statute and how it is implemented during the main steps of the process leading to an arrest warrant. It is demonstrated that prosecutorial discretion is limited by complementarity and cooperation issues between State Parties. Therefore it restricts the Prosecutor’s ability to ending conflicts.  The third chapter analyses two ongoing situations at the International Criminal Court that is Uganda and Darfur, as to verify if the Prosecutor can have an effect on ongoing conflicts. It is concluded that in the current Rome Statute, the Prosecutor is dependent on State Parties cooperation to influencing conflict resolution.

Keyphrases: Justice, International criminal court, Prosecutor, Peace, Justice, Uganda, Darfur
Détection des chutes par calcul homographique

The main objective of video surveillance is to protect persons and property by detecting any abnormal behavior. This is not possible without detecting motion in the image. This process is often based on the concept of subtraction of the scene background. However in video tracking, the cameras are themselves often in motion, causing a significant change of the background. So, background subtraction techniques become problematic. We propose in this work a motion detection approach, with the example application of fall detection. This approach is free of background subtraction for a rotating surveillance camera. The method uses the camera rotation to detect motion by using homographic calculation. Our results on synthetic and real video sequences demonstrate the feasibility of this approach.

Keyphrases: Camera rotation, points SIFT, SIFT keypoints, points SURF, SURF keypoints, matching, homography, motion detection, fall detection
Systématisation du contenu théologique de l’expression « nouvelle évangélisation » à la lumière de la théologie pastorale de Jean-Paul II

The entire pontificate of Pope John Paul II, polarized by the event of the Jubilee of the year 2000, can be summarized as a long pilgrimage of the Catholic Church towards the Third Millennium of humanity. At the dawn of the XXIst century, having as a sure guide the theological contents of Vatican Council II, the Polish Pope held up for all to see an original pastoral vision marked by the expression “new evangelization”. Borrowed from the Latin American Bishops this expression became his emblem and spearhead during nearly 27 years of pontificate. Since it has been largely appropriated by various ecclesial groups, a systematic study of the expression, in the light of the pastoral theology of its privileged discloser, had to be initiated. To do so we chose, as founding text of our study, the Apostolic Letter Tertio Millennio Adveniente, published in 1994, due to its pastoral vision at the dawn of the year 2000. This text, covering the period of the Vatican Council II up to the entry of the Roman Catholic Church in the Third Millennium, defined the temporal framework of our research and permitted us to retain three theological tenets. We analyzed them and produced a theological synthesis through three synoptic views which gradually led the thesis to its conclusion. The Apostolic Exhortation Evangelii Nuntiandi of Pope Paul VI was the starting point; the second theological tenet was the document of John Paul II entitled Sources of Renewal, and the final tenet was the Post Synodal Exhortation Ecclesia in America. By the analysis and the synthesis of these three tenets, with a justified hermeneutical initiative, three outcomes emerged. The first one looked at the pastoral application of the Vatican Council II: in a pastoral outlook justified by a defined anthropology, the minister articulated the Constitutions Lumen Gentium and Gaudium et Spes to suggest a pastoral praxis. The second outcome then developed the notion of the creativity of the faith. This creativity of the faith declined itself in the cultural mediations  – third outcome – which articulate themselves around the concepts of attitudes and Wojtylien dialogue. The proposed critical conclusion of the thesis directly concerned the anthropology proposed by John Paul II underlying in each of these three outcomes.

Keyphrases: Evangelii Nuntiandi, Dialogue, New Evangelization, John Paul II, Pastoral Theology, Vatican Council II, Jubilee of the Year 2000, Christology, Ecclesiology, Hermeneutics
Jeunes filles mineures traduites devant la Cour des jeunes délinquants de Montréal de 1912 à 1949 : problèmes et procédure judiciaire

The objective of this thesis is to describe, understand and explain the treatment of young girls brought before the Montreal Juvenile Delinquents Court during the course of its existences from 1912 to 1950. First, a sample of 1,465 young girls for which we had extracted information from the court register was used in a quantitative statistical analysis. Second, a documentary analysis was used on a subsample of 126 girls based on various documents contained in their legal files.   Several conclusions can be drawn from these analyses. One of them is that young girls brought before the Court were treated differently from boys who appeared before this same court. This means that the enforcement of the law differed depending on the sex of the minors brought into the juvenile justice system. Indeed, young girls were prosecuted for different reasons than boys. Girls were charged with incorrigibility, sexual related offenses, desertion and protection while boys were mostly charged with criminal offenses related to the Criminal Code. Furthermore, girls were more often taken into the juvenile system by their own parents rather than by officers of the Court. They also faced measures that differed from those imposed on boys for the same offence. Girls were more frequently placed in institutions or foster homes whereas boys were more often put on probation. The definition of what was problematic with these youngsters as well as the desirable solutions to their problems varied greatly according to various actors (probation officers, Court’s officers, parents and young girls).

Keyphrases: Montreal Juvenile Delinquent’s Court, Delinquency, Juvenile, Youth, Female delinquency
Systèmes superintégrables avec spin et intégrales du mouvement d’ordre deux

This thesis is part of a research program studying superintegrable systems with spin. In particular, we consider a Hamiltonian with a spin-orbital interaction in three dimensions admitting an integral of motion that is a matrix polynomial second order in the momenta. Since we are considering a Hamiltonian which is invariant under rotation and parity, we classify the integrals of motion into irreducible O(3) multiplets. We obtain the commutator of the Hamiltonian with the scalar, pseudoscalar, vector and axial vector operators. We provide a complete classification for the scalar and vector cases. We find the necessary condition for superintegrability on the potential as a differential equation. We use symmetry reduction methods to obtain particular solutions of this equation.

Keyphrases: Quantum superintegrability, Superintegrable, Symmetries, Spin, Spin-orbital
Étude numérique des premières étapes d'agrégation du peptide amyloïde GNNQQNY, impliqué dans une maladie à prion

Amyloid proteins are involved in neurodegenerative diseases such as Alzheimer’s, Parkinson’s and prion diseases and form complex structures called amyloid fibrils. The fibril formation mechanism is a complex process, which involves several intermediary species. Among these species, small early aggregates, called oligomers, are thought to be the toxic amyloid species but their toxicity and aggregation mechanisms are poorly understood. This thesis aims at presenting the results of a numerical study of the first oligomerization steps of the model peptide GNNQQNY, from a prion protein, for system sizes ranging from the trimer to the 50-mer, via molecular dynamics simulations using the OPEP coarse-grained potential. We find that GNNQQNY’s assembly follows a complex nucleation process, as observed experimentally for numerous amyloid proteins. We also observe that the 20-mer and 50-mer systems form polymorphic structures that are the byproducts of different formation pathways. We further report the spontaneous formation of protofibrillar oligomers with structural characteristics typical of experimentally determined amyloid fibril structures.

Keyphrases: amyloid fibrils, prion, GNNQQNY, protein aggregation, nucleation, oligomers, protofibres, protofibrils
Study on the activation of the biceps brachii compartments in normal subjects

The latest myoelectric prostheses have several degrees of freedom and therefore require a large number of myoelectric signals to fully exploit their capabilities. Muscle compartments, which are intra-muscular subdivisions innervated by an individual muscle nerve branch, can be exploited to provide additional independent muscle control sites to operate such prostheses. This research presents a work to investigate the activation of the 6 biceps brachii compartments in healthy subjects to see if they have the ability to activate those compartments voluntarily. Therefore, electromyographic (EMG) signals were recorded from an array of seven and ten pairs of equally spaced surface electrodes positioned across the short and long head of the biceps of ten healthy subjects. The EMG signals are collected in two positions: 1) with the subject seated, right elbow flexed ~100°, and 2) with the subject standing with the right arm extended horizontally in the coronal plane (90°shoulder abduction). In both positions, the hand is either fully supinated, neutral, or fully pronated. The average root mean square value of the EMG signals obtained from the pairs of electrodes positioned over the short head are compared with the average obtained for the other pairs placed over the biceps long head. Ultrasound imaging also used to visualize the long and short heads of the biceps in flexed and extended arm while the hand was in different postures. Depending on the task to be accomplished, activity was larger in one head or in the other. Being able to activate either head of the biceps, while not yet completely independently, suggests that the selective use of compartments could be a possible avenue for controlling upper limb myoelectric prostheses.

Keyphrases: BIceps brachii, compartment, Electrode array, Surface EMG, Ultrasound
Le niveau réduit d’AMPc dans la surexpression des protéines G(alpha)i et la prolifération accrue des cellules du muscle lisse vasculaire des rats spontanément hypertendus

We have previously shown that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit enhanced expression of inhibitory G proteins (Gi) and enhanced cell proliferation as compared to VSMC from Wystar-Kyoto rats (WKY). The levels of cAMP were shown to be decreased in VSMC from SHR. The present study was therefore undertaken to examine the contribution of the decreased intracellular level of cAMP in the enhanced expression of Gi proteins and increased proliferation of VSMC from SHR and to further explore the underlying molecular mechanisms responsible for this response. VSMC from SHR showed an enhanced expression of Giα-2 and Giα-3 as compared to VSMC from WKY which was decreased in a dose-dependent manner by dbcAMP, a cell-permeable cAMP analog. In addition, the enhanced functions of Gi proteins as demonstrated by enhanced inhibition of adenylyl cyclase by inhibitory hormones and forskolin (FSK)-stimulated adenylyl cyclase activity by low concentration of GTPγS in VSMC from SHR were also restored to the WKY levels by dbcAMP. The enhanced proliferation of VSMC exhibited by SHR was also attenuated by dbcAMP and forskolin, an activator of adenylyl cyclase. In addition, dbcAMP also restored the increased production of superoxide anion   (O2-), NAD(P)H oxidase activity and enhanced expression of Nox 4 and p47phox proteins observed in VSMC from SHR to control levels. Furthermore, the increased phosphorylation of PDGF-R, EGF-R, c-Src and ERK1/2 exhibited by VSMC from SHR were also decreased by dbcAMP in a dose-dependent manner. These results suggest that decreased levels of intracellular cAMP exhibited by VSMC from SHR contributes to the enhanced expression of Gi proteins and hyperproliferation through increasing oxidative stress and transactivation of EGF-R, PDGF-R and MAP kinase signaling pathway.

Keyphrases: Rats SHR, Gi proteins, Cell proliferation, cAMP, Oxidative stress, Growth factor receptors, ERK1/2, Vascular smooth muscle cells, SHR
Literary meals in Canada : the Food/books of Austin Clarke, Hiromi Goto, Tessa McWatt and Fred Wah

Literary Meals in Canada examines Austin Clarke’s Pig Tails ’n Breadfruit, Hiromi Goto’s Chorus of Mushrooms and The Kappa Child, Tessa McWatt’s This Body, and Fred Wah’s Diamond Grill. It asks, what does food mean to these stories, what does it allow the writers in question to say—about social structures, culture, language, and subjectivity—and how do they go about making these connections or drawing these conclusions? In other words, what are their food-writing strategies? I also read these texts as part of a larger conversation about food, a conversation taking place in academic circles as well as at the supermarket, on food labels, on television, and other media outlets. I look for moments in which my literary corpus responds to and challenges food-centred discourse. Comprised of four chapters—Production, Procurement, Preparation, and Consumption—this dissertation explicates Rachel Bowlby’s term, “literary supermarket,” through Michael Pollan and Hiromi Goto; it compares Escoffier’s haute cuisine with Austin Clarke’s “hot-cuisine”; it tracks the kinship between “doing-cooking” and writing cooking, as articulated by Luce Giard, Austin Clarke, and Fred Wah; it reads Emily Post’s advice on table manners against Hiromi Goto’s cacophony of gnashing and nibbling; and it pairs Tessa McWatt with Elspeth Probyn, both of whom share a similar approach to, and interest in, bodies that eat. The texts that make up this corpus are foodbooks. Food and the activities and processes associated with it are therefore mediated by language. For this reason the dissertation attends to the particularities and the potential effects of writing food.

Keyphrases: Literary meals in Canada, Foodbooks, Austin Clarke, Hiromi Goto, Tessa McWatt, Fred Wah
Monohalogénocyclopropanations stéréosélectives à l'aide de carbénoïdes de zinc, couplages croisés de cyclopropylsilanols, cyclisations d'iodures d'alkyle catalysées par le nickel

Cyclopropanes are important subunits because of their presence in numerous bioactive natural products and synthetic molecules as well as synthetic intermediates. In this work we have investigated the stereoselective halocyclopropanation of allylic alcohols using a dioxaborolane-type stoichiometric chiral ligand and substituted zinc carbenoids derived from organozinc compounds and haloforms. We have thus developed conditions for the stereoselective iodo-, chloro- and fluorocyclopropanation reactions. A mechanistic study on the nature of alpha-chloro and alpha-bromomethylzinc carbenoids has revealed that halogen scrambling is taking place in the case of these carbenoids. During the chlorocyclopropanation reaction, the most reactive carbenoid (alpha-chloromethyl zinc) reacts predominantly, in line with the Curtin-Hammet principle. The enantioenriched iodocyclopropanes have been functionalized through a lithium-iodine exchange followed by treatment with electrophiles or transmetallation to zinc and Negishi cross-coupling. Therefore, a wide array of enantioenriched 1,2,3-substituted cyclopropanes have been synthesized using these methods.    In order to develop new methodologies for the functionalization of cyclopropanes, we have studied the Hiyama-Denmark cross-coupling of cyclopropylsilanols. In this approach, the silanol group bears two functions: it serves as a proximal basic group in the Simmons-Smith cyclopropanation and it is involved in the transmetallation event during the cross-coupling reaction. In the cross-coupling step, the nature of the ligands bound to the silicon atom is crucial to the efficiency of the reaction. Hence, the in situ formation of the cyclopropyltrifluorosilane via a ligand exchange with boron trifluoride etherate is required for good yields.    The final chapter of this work is on the nickel-catalyzed cyclization of alkyl iodides via a homolytic aromatic substitution mechanism. A series of tetrahydronaphthalene and thiochroman related compounds have been synthesized using this methodology. A mechanistic study has confirmed the radical nature of this reaction and strongly suggests the catalytic role of nickel. DOSY NMR spectrometric investigations have demonstrated an association between substrate, the base employed in this reaction and the nickel complex.

Keyphrases: Stereoselective halocyclopropanation, Simmons-Smith reaction, Zinc carbenoids, Asymmetric synthesis, Cyclopropylsilanols, Hiyama-Denmark cross-coupling, Alkyl iodide cyclization, Nickel catalysis, Homolytic aromatic substitution