NCube/papyrus huggingface dataset:
Les inégalités sociales dans la durée de vie la plus commune : la répartition des décès selon l'âge et le quintile de défavorisation au Québec en 2000-2002 et 2005-2007

"Social inequalities in the most common age at death : the distribution of deaths by age and deprivation quintile in Quebec in 2000-2002 and 2005-2007" We chose to focus our analysis on the social inequalities of mortality at older ages especially. The use of the modal age at death, combined with the dispersion of deaths above this age is particularly adapted to capture such disparities.  Indeed, these measures are not dependent on premature mortality. From the distribution of ages at death by level of deprivation in Quebec during the periods of 2000-2002 and 2005-2007, we determined the most common age at death and the dispersion of deaths above it. We first estimated the distribution of deaths by age and level of deprivation with a nonparametric smoothing approach based on P-splines developed by Nadine Ouellette in her doctoral thesis. Our results show that the modal age at death does not allow to detect disparities in mortality among women by level of deprivation in Quebec in 2000-2002 and in 2005-2007. Nevertheless, mortality shifted to older ages, while the compression of mortality seems to have stabilized. For men, social inequalities in mortality are particularly important between the most and least favored subgroups. There is a shift in male modal age at death towards older ages, regardless of the level of deprivation. However, unlike their female counterparts, the phenomenon of compression of mortality still seems ongoing.

Keyphrases: deprivation, modal age at death, social inequalities, P-spline smoothing, Quebec, mortality compression
L'alimentation selon l'âge et la culture : une analyse logico-naturelle des représentations construites par des enfants canadiens/québécois et roumains

This research focuses on children’s representations of food and nutrition from a constructivist epistemological perspective based on an interdisciplinary approach integrating communication and social psychology. Our goal was to determine which representations of food and nutrition could be understood as social representations, and if children’s age and cultural background interfered with the development of those representations. The subjects were children aged 7 to 12 from three different cultural backgrounds - we compared representations of food and nutrition built by children born, raised and educated in Romania and Quebec, as well as children from families of Romanian immigrants born (or raised from a very young age) in Quebec. The research methodology integrated social psychology and communication perspectives, instrumentally derived from natural logic and theories on social representations. Results suggest that children build social representations of food and nutrition, and that these representations become progressively more complex, undergoing a similar developmental process, according to children’s age, both from a cognitive and moral viewpoint. Moreover, the research highlights that socio-cultural background influences on the representations content and complexity refer either to cultural or ideological influences with regards to the differences and similarities between socio-cultural groups. Furthermore, we proposed scenarios of communication strategies aiming to increase the effectiveness of nutritional education programs. Finally, the research provides contributions to theories of social representations and child development as well as to the development of new methods for the analysis of representations.

Keyphrases: representations of food and nutrition, social representations, natural logic, healthy food, junk food, nutritional education, developmental research
Facteurs associés à la présence d’une orchidée rare au Québec : Arethusa bulbosa L

Arethusa bulbosa L. is a peatland orchid rare in Québec because of the small size of its populations and the pressures on its habitat. It is known to be intolerant to edaphic changes of its habitat, and particularly to drainage. To determine if A. bulbosa is a good indicator species of the ecological integrity of peatlands, this study compares plots where the species is present from plots where it is absent. During the summers of 2009 and 2010, 37 peatlands were surveyed in southern Québec. Discriminant analyses were performed to find which natural or anthropogenic factors best explain the difference between plots with or without the orchid. Also, indicator species of the presence of A. bulbosa were found using INDVAL analyses. Overall, the results suggest that A. bulbosa was mostly growing in peatlands characterized by minerotrophic conditions. Two evidences supported this point, the high pH values measured and the presence of indicator species of minerotrophy in plots with the orchid. It is likely that A. bulbosa is favored by a certain interception of light by scattered trees or species growing in lower strata. Finally, despite a high floristic quality assessment index (FQAI) in A. bulbosa plots, it is likely that the species takes advantage of small-scale disturbances in it habitat and is therefore not a good indicator species of peatlands ecological integrity.

Keyphrases: Arethusa bulbosa, Plante rare, Dragon's-mouth, Orchid, Peatland, Rare species, Plant indicator species, Disturbance
L’attribution au Liban du comportement du Hezbollah selon le droit international de la responsabilité de l’État

The 33 days of war that took place in Lebanon in the months of July and August 2006 have given rise to a wide range of questions about the legality of Israel’s use of force on behalf of its so-called right to self-defence. The issue at stake is mostly the result of the fact that the attack which provoked the beginning of the hostilities, on 12 July 2006, was performed by Hezbollah, an armed group whose status as a State or non-State actor remains difficult to pinpoint. This study puts forward the analysis of whether Lebanon must be held accountable for Hezbollah’s actions. A review of the history of Lebanon and of Hezbollah’s creation illustrates that the relationship between these two actors is particularly complex and that Hezbollah’s status is still widely contested. This will directly influence the answer to the question of the attribution of Hezbollah’s actions to the Lebanese State. An in-depth study of the international principles regulating the act of « attribution », a pivotal concept in the international law on the responsibility of States, will reveal that discerning the nature of the link between a State and an entity whose actions are contested is extremely important. In today’s world, where non-State actors have a major role on the international scene, and in the case of Hezbollah in Lebanon – an armed militia operating from within a State with limited sovereignty – the notion of attribution itself might lose much of its significance.

Keyphrases: Hezbollah, Lebanon, Hezbollah, State responsibility, Non-State actors, International Law Commission, Sovereignty, Due diligence, Failed States, Terrorism, International legal personality
Liens prédictifs entre l’agressivité proactive et la délinquance : le rôle modérateur des normes prosociales du groupe-classe et du rejet par les pairs

The purpose of this study is to examine the predictive relationships between the behavior of proactive aggression in childhood and adolescent delinquency, and possibly the effect of moderating standards prosocial class group and the rejection by the peer group. Specifically, linkages will be examined: 1) the main positive link between proactive aggression in childhood and adolescent delinquency, 2) the moderating effect (ie, guard) first-level standards in prosocial class group on the link between proactive aggression and delinquency and 3) the moderating effect of the second level of peer rejection, given the dampening effect of the first level of prosocial norms of their class group. Two theoretical models are used to support the choice of assumptions and provide a framework in interpreting the results: The model group and model group similarity person. The data come from a sample of 327 children were assessed at six times the age of 10 years (ie, grade 4) and 15 (third year of secondary). Delinquency was measured using self-reported data by participants. Standards prosocial class group are based on average ratings made by teachers of prosocial behavior in their class. The rejection by peers was measured using sociometric assessments in group classes. The hierarchical linear regression models were used. The results show a positive link between proactive aggression in childhood and adolescent delinquency. Despite obtaining a marginal interaction coefficient, the results indicate that moderate pro-social norms, but increasing, the link between aggression and delinquency. The moderating effect of peer rejection is not as significant. These results will be discussed to better understand the link between aggression and elements of social context in which the child grows, and their involvement in the prevention of problems with aggression and delinquency in schools.

Keyphrases: Proactive aggressiveness, Delinquency, Rejection by peers, Prosocial standards, Moderators, School, Prevention
Las trayectorias de los estudiantes universitarios : un modelo integral =
Les trajectoires des étudiants universitaires : un modèle intégré

We developed a model that seeks to identify the determinants of university student academic paths articulating two theoretical perspectives trough the use of a mixed methodological approach in two phases: quantitative and qualitative.  First, the quantitative model based on Tinto (1992) with the incorporation of other variables from Crespo and Houle (1995). This phase attained two purposes. In the first, were determined the differences between the exogenous variables (economic index, parents’ educational level, high school average and average of the entrance exam) and three types of trajectory: persistent, lagged and attrition. This phase was based on data from a survey applied to 800 students at the University of Sonora (Mexico). The results show that those who left the institution had scores significantly lower at the exogenous variables. The second objective was achieved from the trajectories persistent and lagged. It was found that there is a greater chance of having a persistent trajectory when students have a high academic integration, better scores on the entrance exam, more employment expectations, having obtained a scholarship and being a woman. In the second phase a deeper understanding (verstehen) of the processes of articulation between the academic and social integration was developed through three registers: integration, project and vocation, as proposed by Dubet (2005). This phase consisted in conducting of 30 interviews with students of all three types of trajectories. From the work of Bourdages (1994) and Guzman (2004), we sought the meaning of the experience given by the students to the educational process. The results reveal five groups of students with identifiable college experiences: the ones with highest academic and social integration, the female workers with academic integration, the ones most economically disadvantaged and lower academic integration, those who sought his vocation in a different institution and the ones who dropped out. The use of different statistical tools (correlation analysis, logistic regression analysis and cluster analysis) handled in the first phase identified key variables in each type of trajectory, which were validated with the results of the qualitative phase. This thesis, in addition to showing the usefulness of a mixed methodological approach, extends the Tinto’s model (1987) and confirms the importance of academic integration for persistence in university studies.

Keyphrases: Trajectories of university students, Social integration, Academic integration, Persistence, Delay, Attrition
Amélioration de l'exactitude de l'inférence phylogénomique

The explosion of sequence number allows for phylogenomics, the study of species relationships based on large multi-gene alignments, to flourish. Without any doubt, phylogenomics is essentially an efficient way to eliminate the problems of single gene phylogenies due to stochastic errors, but numerous problems remain despite obvious progress realized in modeling evolutionary process. In this PhD-thesis, we are trying to characterize some consequences of a poor model fit and to study their impact on the accuracy of the phylogenetic inference. In contrast to heterotachy, the variation in the amino acid substitution process over time did not attract so far a lot of attention. We demonstrate that this heterogeneity is frequently observed within animals, but also that its existence can interfere with the quality of phylogenomic inference. In absence of an adequate model, the elimination of heterogeneous columns, which are poorly handled by the model, can eliminate an artefactual reconstruction. In a phylogenomic framework, the sequencing strategies often result in a situation where some genes are absent for some species. The issue about the impact of the quantity of empty cells was recently relaunched, but the majority of studies on missing data is performed on small datasets of simulated sequences. Therefore, we were interested on measuring the impact in the case of a large alignment of real data. With a reasonable amount of missing data, it seems that the accuracy of the inference is influenced rather by the choice of the model than the incompleteness of the alignment. For example, the addition of an incomplete sequence that breaks a long branch can at least partially re-establish an artefactual phylogeny. Because, model violations are always representing the major limitation of the accuracy of the phylogenetic inference, the improvement of species and gene sampling remains a useful alternative in the absence of an adequate model. Therefore, we developed a sequence-selection software, which allows the reproducible construction of datasets, based on the quantity of data, their evolutionary speed and their compositional bias. During this study, we did realize that the human expertise still furnishes an indispensable knowledge. The various analyses performed in the course of this PhD thesis agree on the primordial importance of the model of sequence evolution.

Keyphrases: Phylogenomics, Accuracy of the inference, Heteropecilly, Heterogeneity of the evolutionary process, Species sampling, Sequence sorting, Missing data, Model violation
Modulation de la signalisation du récepteur de type 2 du facteur de croissance de l’endothélium vasculaire (VEGFR-2) par l’ubiquitination

Abstract Angiogenesis is one of the most important processes to maintain oxygen homeostasis throughout the different tissues. The different signaling pathways of the vascular endothelial growth factor receptor 2, VEGFR-2, play a primordial role in the angiogenic response induced by different angiogenic factors, one of which is the vascular endothelial growth factor, VEGF. Following VEGFR-2 activation, many signaling cascades are triggered in endothelial cells; in order to attenuate this response, VEGFR-2 undergoes multi ubiquitination on lysine residues and in this fashion it is brought into the degradation pathways, mainly through the lysosomes. This ubiquitination is induced by the association of the ubiquitin ligase (E3) c-Cbl to a phosphorylated tyrosine residue in the c-terminal domain of VEGFR-2. In this study, we identified tyrosine residue 1319 as being necessary for the association of c-Cbl to VEGFR-2 and for its ubiquitination. Our results show as well that overexpression of the mutant Y1319F version of VEGFR-2 in bovine aortic endothelial cells, BAEC, slows down the degradation process of VEGFR-2 and at the same time increases and prolongs the activation of endothelial nitric oxide synthase, eNOS. These results allow us to better understand the process of VEGFR-2 signaling regulation at the intracellular level. Keywords: [Angiogenesis, VEGFR-2, VEGF, c-Cbl, Ubiquitination, Tyrosine 1319, Degradation]

Keyphrases: VEGFR-2, VEGF, c-Cbl, Ubiquitination, Tyrosine 1319, Angiogenesis
La expresión del deseo en la literatura femenina como respuesta a la opresión dictatorial y patriarcal en la obra de Luisa Valenzuela

This thesis studies the antiauthoritarian specificity of the short stories that Luisa Valenzuela published in the Cambio de armas (1982) and Simetrías (1993), written during the military dictatorship (1976-1983), and ten years after the return to dictatorship. The analysis of the stories establishes a dialogue with Valenzuela’s essay Peligrosas palabras (2001) and with different theoretical perspectives that we study in each chapter (socio-linguistic, feminist theory, and cultural criticism).  This study emphasizes how the expression of desire, in Valenzuela’s work, criticizes the relations of domination that appear during the dictatorship and in the patriarchal society. The short stories 1) denounce the effects of repression on the subject trough open sexuality and a rejection of the public-private division: 2) underline the materiality of the body, marked by social and power relations, allowing for the creation of a feminine objectivity without separating the body from the mind; 3) create new ways of representing memory, allowing for a redefinition of the relations to history and to the other. In Valenzuela’s discourse, desire is presented as a demand for equality in social relationships, and for an alternative vision of language, subjectivity, and memory.

Keyphrases: Luisa Valenzuela, Argentine literature, Hispanic women's writing, Antiauthoritarian discourse, Dialogism, Dialogismo
Le rôle de la barrière hémato-encéphalique dans la pathogénèse de l'oedème chez des rats souffrant d'insuffisance hépatique chronique

Brain edema is a complication associated with hepatic encephalopathy (HE) due to chronic liver failure (cirrhosis). It is unclear whether brain edema is of vasogenic (blood brain barrier (BBB) breakdown) or cytotoxic (abnormal cellular uptake of ions) origin. It has been demonstrated that the Na-K-Cl cotransporter (NKCC1) located on the luminal side of the cerebral microvessels (CMV) is implicated in the pathogenesis of brain edema in animal models of ischemia and that the administration of bumetanide, an inhibitor of NKCC, attenuates brain water increase. Two distinct animal models of chronic liver failure and HE are used in the present study; 1) bile duct ligation (BDL) where brain edema, chronic hyperammonemia and systemic oxidative stress are observed; 2) portacaval anastomosis (PCA) where only chronic hyperammonemia is observed. The aims of the study were to: i) determine the origin of brain edema in BDL rats measuring brain extravasation, tight junctions expression and matrix metalloproteinase activation; ii) observe the effects of chronic hyperammonemia on the BBB in PCA rats; iii) study the role of oxidative stress and hyperammonemia; iv) evaluate the role of NKCC in CMV in the pathogenesis of brain edema. The results of the study determined that brain edema in BDL rats is of cytotoxic origin and chronic hyperammonemia independently has no effect on the BBB. An increase of NKCC1 mRNA is associated with brain edema but protein expression and phosphorylation are not. Furthermore, hyperammonemia and oxidative stress independently are not implicated in the development of brain edema however a synergistic effect between the two pathogenic factors in BDL rats remains a possibility.

Keyphrases: AST-120, bumetanide, NKCC1, hepatic encephalopathy, hyperammonemia, blood brain barrier, NKCC1, bumetanide, AST-120, bile duct ligation, portacaval anastomosis, cytotoxic edema
Étude génétique et fonctionnelle de variantes de la région chromosomique 3p21 associée aux maladies inflammatoires de l'intestin

Linkage studies and association studies allowed the discovery of some of the genetic risk factors of inflammatory bowel disease (IBD) in the chromosomal region 3p21. In this region, the non-synonymous coding single nucleotide polymorphism (SNP) rs3197999, situated in the gène MST1 and encoding for the mutation R689C, has been associated to UC and CD multiple times, and an other SNP, correlated to non-synonymous coding SNPs in the gene MST1R, has also been associated to CD. In order to verify if other variants of MST1 and MST1R are associatied to UC, we tested the association of some of their SNPs. Apart from R689C, only its proxy showed a significative association signal to IBD. It suggests that R689C might be the causal variant of IBD in the region 3p21.  In the aim to determine if the region 3p21 has multiple independant association signals, 3 SNPs have been identified, from the results of a published meta-analysis of UC genome-wide association studies, as being possibly independant risk factors for UC based on their correlation.  Their association to IBD and their independance have been tested by genotyping them in a cohort composed of controls, and UC and CD cases. The results of the association tests have been combined, in a meta-analysis, to the results of 3 other independent association studies.  The 3 SNPs, R689C (MST1), rs6802890 and rs7629936 (CDHR4) are associated to IBD, but the results of the subsequent conditional association tests suggest that there is only 2 independant association signals in the region 3p21. The main signal is raising from R689C, a mutation of the protein MSP. According to published studies, this protein has a function in the inflammation in murine macrophages, and also in the scattering, wound healing and survival of epithelial cells.   In this thesis, we investigated the role of MSP in human macrophage models and in human côlon epithelial cells, and it has been show that MSP modulates the phosphorylation of AKT, an actor in the pathway of cellular survival. This project brought some knowledges about the IBD genetic risk factors in the region 3p21. We identified 2 independent association signals to IBD in this region, and the main signal is coming from a SNP in MST1, a gene which has a role, based on our results, in the survival in human colon epithelial cells.

Keyphrases: 3p21, 3p21, MST1, MST1, MST1R, MST1R, association, association, meta-analysis, inflammatory bowel diseases, ulcerative colitis, Crohn’s disease, phosphorylation of AKT