NCube/papyrus huggingface dataset:
Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model

Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.

Keyphrases: Acetylcholinesterase inhibitors, Bone healing, Osseointegration, Donepezil, Hemostasis
Contribution of a reflective debriefing to nursing students' clinical judgment in patient deterioration simulations : a mixed-methods study

Background While reflection is a hallmark of debriefing, there is little understanding of how it contributes to nursing students' clinical judgment.  Objectives The aim of this study was to describe how nursing students perceived that the Reflective dEbriefing after a PatieNt Deterioration simulation (REsPoND) fostered learning and how it contributed to their clinical judgment in patient deterioration simulations.  Design A sequential explanatory mixed-methods study.  Participants Nineteen students who showed the greatest clinical judgment score variation in a randomized controlled trial of the effectiveness of REsPoND.  Methods Students participated in interviews on their learning experience in REsPoND. Data were subjected to thematic analysis and themes were contrasted according to students' score variations.  Results Through guided exchanges with their peers, students configured a causes–observations–interventions framework that embodied their understanding of the patient's situation. They evaluated their own simulation performance based on that framework. The contribution of REsPoND to students' clinical judgment differed depending on (1) the value placed on the review of the simulation through a systematic assessment approach; (2) their focus on anticipating the situation or on performing in the simulation; and (3) their preference for who participated more in debriefing.  Conclusion Clinical judgment might be improved when a systematic assessment approach is used to structure debriefing. The relationship between reflection and self-assessment during debriefing remains to be disentangled.

Keyphrases: Clinical judgment, Debriefing, Nursing students, Patient deterioration, Plus-Delta, Mixed-methods, Reflection, REsPoND, Simulation
La place du bonheur dans la doctrine de la vertu

Le lecteur de la Critique de la raison pratique risque d’être intrigué par le fait que Kant affirme dans l’Analytique que le bonheur ne doit jouer aucun rôle dans la motivation à agir selon la loi morale, alors que la Dialectique réintroduit de manière inopinée le thème du bonheur comme faisant l’objet d’une attente raisonnable de la part du sujet moral vertueux. Or, tant Fichte que Schopenhauer exprimeront des réserves face à ce geste de Kant. Dans cet article, je cherche à montrer que les trois explications habituellement fournies pour rendre plausible cette espérance en un bonheur proportionnel à la vertu sont sujettes à caution : 1) le dualisme ontologique (suprasensible/sensible), 2) le préjugé religieux de Kant (F. Schroeter) et 3) une concession faite par Kant à la faiblesse de la nature humaine (L. W. Beck). J’avance alors une autre explication, fondée sur la conception kantienne de la raison pratique. The reader of the Critique of Practical Reason is often puzzled by Kant’s claim in the Analytic that happiness must not play any role in the motivation to act according to the moral law, whereas the Dialectic unexpectedly reintroduces the topic of happiness as a reasonable expectation from the part of the virtuous moral subject. In fact, both Fichte and Schopenhauer had reservations about this move. In this paper I argue that the three explanations usually provided in order to make sense of the hope for happiness are questionable: 1) the ontological dualism (intelligible/sensible), 2) Kant’s religious prejudice (F. Schroeter), and 3) a concession made by Kant to the weakness of human nature (L. W. Beck). I give another explanation, based on Kant’s conception of practical reason.

Keyphrases: Kant, Fichte, Schopenhauer, Souverain bien, Bonheur, Salaire, Kant, Fichte, Schopenhauer, Remuneratio gratuita, Highest good, Happiness, Salary
Examining the impact of a social skills
training program on preschoolers’ social
behaviors : a cluster-randomized controlled
trial in child care centers

Background Preschoolers regularly display disruptive behaviors in child care settings because they have not yet developed the social skills necessary to interact prosocially with others. Disruptive behaviors interfere with daily routines and can lead to conflict with peers and educators. We investigated the impact of a social skills training program led by childcare educators on children’s social behaviors and tested whether the impact varied according to the child’s sex and family socio-economic status.  Methods Nineteen public Child Care Centers (CCC, n = 361 children) located in low socio-economic neighborhoods of Montreal, Canada, were randomized into one of two conditions: 1) intervention (n = 10 CCC; 185 children) or 2) wait list control (n = 9 CCC; 176 children). Educators rated children’s behaviors (i.e., disruptive and prosocial behaviors) before and after the intervention. Hierarchical linear mixed models were used to account for the nested structure of the data.  Results At pre-intervention, no differences in disruptive and prosocial behaviors were observed between the experimental conditions. At post-intervention, we found a significant sex by intervention interaction (β intervention by sex = − 1.19, p = 0.04) indicating that girls in the intervention condition exhibited lower levels of disruptive behaviors compared to girls in the control condition (f2 effect size = − 0.15). There was no effect of the intervention for boys.  Conclusions Girls may benefit more than boys from social skills training offered in the child care context. Studies with larger sample sizes and greater intervention intensity are needed to confirm the results.

Keyphrases: Childcare-based intervention, Child development, Social skills, Early childhood education, Problem behavior
Assessment of library liaison programs

Session Format: Lighting talks by three librarians interspersed with facilitated small group breakout activities and discussion. Objective: This session aims to further the conversation about the evolving nature of liaison roles and duties. Through activities, attendees will explore differences in liaison roles and examine the evolution of the liaison librarian in health sciences libraries. Facilitated activities provide an opportunity to brainstorm and discuss what’s next for the role of the liaison librarian. Attendees will share information about ways to assess liaison duties and gain insights that further develop their familiarity with functional support models and other methods to support library users.Instructional  Methods: Lightning talks will present background information on three topics relevant to liaison models. The attendees will further explore these topics through inquiry-based learning activities. Using a participant-centered teaching approach, attendees will work collaboratively with information related to the lightning talk topic, summarize and categorize this information, arrive at questions based on their own experience that further elucidate the content, and then synthesize group findings by sharing back finding with all participants. Facilitators will float among the tables to provide guidance on all activities. Participant Engagement: Participants will be asked to respond to lightning talks through a combination of facilitated small group activities and discussion based on Liberating Structures activity plans. During the activities and discussion, participants will record notes and takeaways into a shared online document that will combine across all groups and will be shared with participants and broader MLA membership after the conference as a follow-up.

Keyphrases: Évaluation, Assessment, Bibliothécaires universitaires, Academic librarians, Bibliothécaires disciplinaires, Liaison librarians
Enhancing relationships between criminology and cybersecurity

‘Cybercrime’ is an umbrella concept used by criminologists to refer to traditional crimes that are enhanced via the use of networked technologies (i.e. cyber-enabled crimes) and newer forms of crime that would not exist without networked technologies (i.e. cyber-dependent crimes). Cybersecurity is similarly a very broad concept and diverse field of practice. For computer scientists, the term ‘cybersecurity’ typically refers to policies, processes and practices undertaken to protect data, networks and systems from unauthorised access. Cybersecurity is used in subnational, national and transnational contexts to capture an increasingly diverse array of threats. Increasingly, cybercrimes are presented as threats to cybersecurity, which explains why national security institutions are gradually becoming involved in cybercrime control and prevention activities. This paper argues that the fields of cyber-criminology and cybersecurity, which are segregated at the moment, are in much need of greater engagement and cross-fertilisation. We draw on concepts of ‘high’ and ‘low’ policing (Brodeur, 2010) to suggest it would be useful to consider ‘crime’ and ‘security’ on the same continuum. This continuum has cybercrime at one end and cybersecurity at the other, with crime being more the domain of ‘low’ policing while security, as conceptualised in the context of specific cybersecurity projects, falls under the responsibility of ‘high’ policing institutions. This unifying approach helps us to explore the fuzzy relationship between cyber-crime and cyber-security and to call for more fruitful alliances between cybercrime and cybersecurity researchers.

Keyphrases: Cybercrime, Cyber harms, Cybersecurity, Criminology, Networks, Security, Security actors
Inclusion of relatives in stroke rehabilitation : Perception of quality of services they received in the context of early supported discharged (ESD), in- and out-patient services

Background Relatives of stroke patients should be an integral part of the continuum of rehabilitation services.  Objective The objective was to describe their perception of the quality of the services they received in the context of early supported discharged (ESD), in- and out-patient rehabilitation services.  Methods Descriptive study using the Quality of Services Questionnaire for Relatives post-stroke (QSQR) completed online by relatives after the patient’s discharge. It consists of 22 statements with respect to three subscales: 1) the training/instructions, 2) the information provision and 3) the organizational process of the service offer. Space is allowed for free comments and two open-ended questions. Quantitative data were analyzed descriptively, and we used a content analysis for qualitative data.  Results One-third (30/90; 33.3%) of the sample are composed of relatives aged 55 and under, with a majority (81%) of women and 51.3% of spouses. The training/instructions and information provision were perceived positively with a mean % agreement at 85.0 ± 29.6 and 84.8 ± 22.4, respectively. The mean % agreement was 91.4 ± 17.8 for the organizational process subscale. A significantly higher score (p = 0,03; Kruskal Wallis test) was found for out-patient services (n = 20) as compared to ESD (n = 29) or in-patient rehabilitation (n = 41). Qualitatively, a lack of involvement of relatives was mentioned as well as a lack of personalized information about stroke and its consequences and provision of resources available. However, communication between professionals, their availability, and their professionalism were appreciated.  Conclusion Despite quantitative high scores, qualitative data allowed the identification of concrete avenues for improvement to truly and systematically include relatives in stroke rehabilitation.

Keyphrases: Stroke, Rehabilitation, Relatives, Quality of services, Early supported discharged, Information and training
Longitudinal associations between delinquency, depression and anxiety symptoms in adolescence : testing the moderating effect of sex and family socioeconomic status

Purpose To examine the cross-lagged associations between delinquency (nonviolent and violent), depression and anxiety symptoms in adolescence and to test the moderating effect of sex and family socioeconomic status (SES).  Methods Participants (n=1,515) were from a birth cohort in the Canadian province of Quebec. Autoregressive cross-lagged panel analyses were used to examine the associations between delinquency (nonviolent and violent), depression and anxiety symptoms from ages 15 to 17 years, while taking into account conduct and emotional problems at ages 10-12 years.  Results Findings suggest that delinquency (violent delinquency especially) and depression symptoms may develop according to a spiraling model, such that conduct problems in childhood give rise to depression symptoms in mid-adolescence, which in turn, contribute to more delinquent acts at the end of adolescence. Family SES, but not sex, had a moderating effect on the paths. We found that anxiety symptoms at age 15 years were associated with nonviolent delinquency at age 17 years when family SES was low, and that violent delinquency at age 15 years was associated with anxiety symptoms at age 17 years when family SES was high.  Conclusions Delinquency and emotional problems do not develop independently from each other; both dimensions should be examined simultaneously.

Keyphrases: Nonviolent and violent delinquency, Depression and anxiety symptoms, Adolescence, Cross-lagged associations, Sex differences, Family socioeconomic status
More ‘Europe’, less Democracy? : European integration does not erode satisfaction with democracy

The process of European integration, through institutions such as the European Union, the Eurozone, or Schengen, implies a shift in political decision-making away from the national governments and towards international institutions. This gradual shift in the balance of power, furthermore, is increasingly debated by citizens. As a result, European integration might lead to an erosion of satisfaction with democracy in European countries. By means of a longitudinal analysis of the determinants of satisfaction with democracy in European countries, we test this expectation. We find no indication that the shift in the balance of power, and the trend towards more European integration indeed have eroded satisfaction with the functioning of (national) democracy.

Keyphrases: Europe, European integration, Satisfaction with democracy, Democratic deficit
Posterior cortical atrophy : impact on daily living activities and exploration of a cognitive rehabilitation approach

Posterior cortical atrophy (PCA) is a neurodegenerative disease affecting the posterior region of the brain. Little is known about both the impact of PCA on functioning and how to support patients on a daily basis. The purpose of this study was to describe the functional profile of DD, a woman diagnosed with PCA, as well as to explore a pilot cognitive rehabilitation program designed to optimize functioning in daily living. The ADL Profile was used to assess the daily tasks that DD chose to undertake. Four operations, i.e. formulate a goal, plan, carry out and verify goal attainment, were scored for each task. Difficulties were observed during the execution of all tasks, as she struggled to find items or showed unsafe behaviors. Impairments were also seen in formulating a goal and planning, especially for less routine tasks. DD identified two tasks to be addressed in rehabilitation: setting the table and dealing cards. Learning was optimized using errorless learning and compensatory aids when setting the table, while dealing cards received no intervention. Only setting the table improved significantly with time. Further studies should be conducted to portray a wider functional profile of people living with PCA and develop effective rehabilitation programs.

Keyphrases: Behavioral sciences, Allied health, Health conditions
Diagnosis and surgical management of cholecystolithiasis in two adult inland beardeddragons (pogona vitticeps)

Two male inland bearded dragons (Pogona vitticeps) of 5 and 6 yr of age were presented for anorexia with and without lethargy, respectively. In both cases, a firm, spherical, and mobile mass, measuring 2 cm in diameter, was palpated in the cranio-medial coelom. Radiographs were unremarkable. Ultrasonographic evaluation was highly suggestive of cholecystolithiasis. Coeliotomy confirmed the presence of a markedly enlarged gallbladder containing a cholecystolith in both cases, and cholecystectomies were performed. Both dragons resumed eating after 1–7 days and were doing well 3–6 months postoperatively. The gallbladder wall was unremarkable on histology, and the choleliths were composed of protein and calcium carbonate crystals. Cholecystolithiasis in bearded dragons has been the subject of very few case reports, probably due to its low occurrence. The lack of available data on the diagnosis and management may have led to this condition being underdiagnosed in this species. Ultrasonography was essential to the clinical diagnosis of cholecystolithiasis in our two cases and should be recommended as part of the diagnostic approach of bearded dragons with cranio-medial coelomic masses.

Keyphrases: Pogona vitticeps, Cholecystectomy, Gallstone, Lizard, Nutrition, Surgery
The 3D-Transition study : objectives, methods, and implementation of an innovative planned missing data design

The prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children’s early vulnerabilities with mental health after the transition to formal schooling. The 3D-Transition study (2017-2021; ClinicalTrials.org ID: NCT04873518) follows 939 participants from a pregnancy cohort in Québec (Canada) as they transition to kindergarten and first grade to examine these mechanisms. Biannual assessments include questionnaires from two parents as well as teachers, parent-child observations, anthropometric measurements, and age-sensitive cognitive assessments. Salivary cortisol is also collected on 11 days over a 16-month period in a subsample of 384 participants to examine possible changes in child salivary cortisol levels across the school transition, and their role in difficulties observed during the transition. A combination of planned missing data designs is implemented to reduce participant burden, where incomplete data is collected without introducing bias after the use of multiple imputation. The 3D-Transition study will contribute to an evidence-based developmental framework of child mental health from pregnancy to school age. In turn, this framework can help inform prevention programs delivered in health care settings during pregnancy, childcare centers, preschools, and schools.

Keyphrases: Childhood, Cortisol, Externalizing, Family, Internalizing, Longitudinal, School, Stress
«En finir avec la géographie» : détournements ludiques de l’écriture du voyage dans Six degrés de liberté de Nicolas Dickner et Document 1 de François Blais

Portés par un imaginaire hérité des récits de voyage ou d’exploration, ainsi que du roman de la route américain et québécois, les romans contemporains Six degrés de liberté de Nicolas Dickner et Document 1 de François Blais subvertissent l’écriture du voyage en mettant en cause ses conventions et ses présupposés, de même qu’en ébranlant une compréhension stable de l’espace. Ces deux textes mettent en scène des déplacements insolites : que ce soit à bord d’un conteneur réfrigéré ou sur le web, traversant de vastes territoires ou choisissant plutôt d’être cloîtrés, les protagonistes y transforment la visée cartographique du voyage. Tout en reprenant et en déplaçant une écriture du voyage codifiée, car marquée par nombre de topoï et de clichés qui apparaissent comme une véritable matière à s’approprier et à travailler, ces deux textes déploient des cartographies singulières, lesquelles mêlent invention et réalité, espaces géographiques et lieux imaginaires. Aussi ce mémoire entend-t-il s’intéresser à la représentation des lieux et du voyage dans ces deux récits, et ce, en portant une attention particulière au jeu que les romanciers instaurent avec leur lecteur, car c’est par le biais d’une ironie ludique que Document 1 et Six degrés de liberté observent et écrivent la réalité contemporaine. Influenced by travel and exploration stories, as well as the American and Quebec road narratives, the contemporary novels Six Degrees of Freedom by Nicolas Dickner and Document 1 by François Blais subvert travel writing by challenging its conventions and assumptions, while interrogating a stable understanding of space. These two novels feature unusual journeys: whether on board a refrigerated container or through the web, crossing vast territories or confined, Blais and Dickner’s protagonists transform the cartographic purpose of travel. As they rewrite codified travel narratives and take over a number of topoï and clichés, these two texts deploy singular cartographies, which mix invention and reality, geographical spaces and imaginary places. This thesis therefore intends to focus on the representation of space and travel in these two novels, with a particular attention to the way novelists play with their reader, for it is through a ludic irony that Document 1 and Six degrees of freedom observe and record today’s reality.

Keyphrases: Nicolas Dickner, François Blais, Littérature québécoise, Ironie, Espace, Space, Nicolas Dickner, François Blais, Roman contemporain, Quebec litterature, Contemporary novel, Space, Irony