NCube/papyrus huggingface dataset:
Universal cannabis outcomes from the Climate and Preventure (CAP) study : a cluster randomised controlled trial

Background: The Climate and Preventure (CAP) study was the first trial to assess and demonstrate the effectiveness of a combined universal and selective approach for preventing alcohol use and related harms among adolescents. The current paper reports universal effects from the CAP study on cannabis-related outcomes over three years. Methods: A cluster randomized controlled trial was conducted with 2190 students from twenty-six Australian high schools (mean age: 13.3 yrs., SD 0.48). Participants were randomised to one of four conditions; universal prevention for all students (Climate); selective prevention for high-risk students (Preventure); combined universal and selective prevention (Climate and Preventure; CAP); or health education as usual (Control). Participants were assessed at baseline, post intervention (6–9 months post baseline), and at 12-, 24- and 36-months, on measures of cannabis use, knowledge and related harms. This paper compares cannabis-related knowledge, harms and cannabis use in the Control, Climate and CAP groups as specified in the protocol, using multilevel mixed linear models to assess outcomes. Results: Compared to Control, the Climate and CAP groups showed significantly greater increases in cannabis-related knowledge initially (p < 0.001), and had higher knowledge at the 6, 12 and 24-month follow-ups. There was no significant difference between the Climate and CAP groups. While no differences were detected between Control and the CAP and Climate groups on cannabis use or cannabis-related harms, the prevalence of these outcomes was lower than anticipated, possibly limiting power to detect intervention effects. Additional Bayesian analyses exploring confidence in accepting the null hypothesis showed there was insufficient evidence to conclude that the interventions had no effect, or to conclude that they had a meaningfully large effect. Conclusions: Both the universal Climate and the combined CAP programs were effective in increasing cannabisrelated knowledge for up to 2 years. The evidence was inconclusive regarding whether the interventions reduced cannabis use and cannabis-related harms. A longer-term follow-up will ascertain whether the interventions become effective in reducing these outcomes as adolescents transition into early adulthood.

Keyphrases: Cannabis, Prevention, Universal, Combined, School, Selective, Online
Why is maternal depression related to adolescent internalizing problems? : a 15-year population-based study

Objective: Exposure to maternal depression during early childhood is a well-documented risk factor for offspring's internalizing problems, but the long-term risk and the psychosocial mechanisms underlying the association remain largely unknown. We examined whether maternal depression during early childhood was associated with offspring internalizing problems in adolescence, and the extent to which negative parenting, peer victimization, and poor friendship quality during middle childhood mediated this association. Method: We report on a population-based sample of children (n=1443) followed-up from 5 months to 15 years. We use yearly assessments of the exposure variable – maternal depression (5 months-5 years); the putative mediators – peer victimization, friendship quality, and parenting practices (6-12 years); and assessment of the outcome variables at 15 years: self-reported major depressive (MD), generalized anxiety (GA), and social phobia (SP) symptoms. Structural Equation Modeling was used to test mediation by peer and family relationships. Results: Exposure to maternal depression during early childhood was associated with higher levels of adolescent MD, GA and SP. Peer victimization was the only significant mediator and explained 35.9% of the association with adolescent MD; 22.1% with GA; and 22.1% with SP. Conclusion: Exposure to maternal depression prior to age 5 years was associated with depression, anxiety, and social phobia extending to adolescence via its impact on peer victimization during middle childhood. Particular attention should be paid to victimization as one potential psychosocial factor via which maternal depression is associated with adolescent internalizing problems.

Keyphrases: Maternal depression, Adolescent internalizing problems, Peer victimization, Parenting, Friendship quality
Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli : a study of adolescent monozygotic twins

Several studies have examined associations between peripheral DNA methylation patterns of the serotonin transporter gene (SLC6A4) promoter and symptoms of depression and anxiety. The SLC6A4 promoter methylation has also been associated with frontal-limbic brain responses to negative stimuli. However, it is unclear how much of this association is confounded by DNA sequence variations. We utilized a monozygotic-twin within-pair discordance design, to test whether DNA methylation at specific CpG sites in the SLC6A4 promoter of peripheral cells is associated with greater frontal-limbic brain responses to negative stimuli (sadness and fear), independently of DNA sequence effects. In total 48 pairs of healthy 15-year-old monozygotic twins from the Quebec Newborn Twin Study, followed regularly since birth, underwent functional magnetic resonance imaging while conducting an emotion-processing task. The SLC6A4 promoter methylation level was assessed in saliva samples using pyrosequencing. Relative to the co-twins with lower SLC6A4 promoter methylation levels, twins with higher peripheral SLC6A4 methylation levels showed greater orbitofrontal cortical (OFC) activity and left amygdala-anterior cingulate cortex (ACC) and left amygdala-right OFC connectivity in response to sadness as well as greater ACC-left amygdala and ACC-left insula connectivity in response to fearful stimuli. By utilising a monozygotic-twin design, we provided evidence that associations between peripheral SLC6A4 promoter methylation and frontal-limbic brain responses to negative stimuli are, in part, independent of DNA sequence variations. Although causality cannot be determined here, SLC6A4 promoter methylation may be one of the mechanisms underlying how environmental factors influence the serotonin system, potentially affecting emotional processing through frontal-limbic areas.

Keyphrases: Depression, Human behaviour
Prédiction de la revictimisation et de la récidive en violence conjugale

En violence conjugale on ne peut négliger l’impact des circonstances immédiates et les caractéristiques individuelles des protagonistes dans la modulation du cours des évènements. Toutefois, peu d’études ont analysé simultanément les effets des circonstances immédiates, des caractéristiques de la victime et de l’agresseur sur la séquence des violences conjugales. L’objectif de cette étude est de mieux comprendre ce qui prédit la revictimisation ainsi que la récidive. Les résultats se fondent sur 52 149 évènements violents commis entre conjoints actuels ou passés enregistrés par les policiers sur le territoire d’une grande ville du Québec, de 2000 à 2009. Nos résultats montrent l’importance du sens de la violence, des expériences de victimisation et des antécédents criminels dans l’explication de la répétition de la violence, tout en nuançant leur effet en fonction de la récidive ou de la revictimisation. Cette étude peut permettre d’orienter les interventions sur plusieurs plans, en améliorant l’efficacité des mesures préventives et en permettant, par exemple, de déterminer des indicateurs facilement observables sur lesquels on peut baser l’intervention afin de mieux répondre au cours des évènements.

Keyphrases: Violence conjugale, Récidive, Revictimisation, Antécédents criminels, Données policières
Only a matter of time? The role of criminal competence in avoiding arrest

While prior research has shown that the probability of detection plays a role in the decision-making of many offenders, much less is known on offenders’ relative success in avoiding arrest. In this study, we draw from detailed criminal career data on 172 offenders involved in lucrative criminal activities to examine the role of criminal competence in the probability of being arrested in a given month. We examine a particular aspect of competence, criminal efficiency, which is defined as the ability to earn a relatively large amount of money for each crime committed. Our research design allows us to disentangle the effect of criminal efficiency as a static trait of offenders from the dynamic variations in efficiency that offenders experience over time. Results show that efficiency is a strong, negative predictor of arrest, both at the static and dynamic levels.

Keyphrases: Arrest, Criminal competence, Criminal efficiency, Exposure time, Criminal careers, Life history calendars
Transformational leadership and incivility : a multilevel and longitudinal test

Objective: This research examines group-level perceptions of transformational leadership (TFL) as negative longitudinal predictors of witnessing person-related (e.g., insults/affronts) and work-related (e.g., negation/intentional work overload) acts of incivility at work. Witnessing workplace incivility was also postulated to negatively predict employee need satisfaction. Method: Data was collected among production employees in different Canadian plants of a major manufacturing company (N = 344) who worked for 42 different managers (Mgroup size = 9.76). Two waves of data collection occurred one year apart. Results: Results from multilevel analyses showed that workgroups where managers were perceived to engage in more frequent TFL behaviors reported reduced levels of person- and work-related incivility one year later. However, group-level incivility did not predict change in group-level need satisfaction one year later. At the individual level, results showed that witnessing higher levels of person-related incivility than one’s colleagues predicted reduced satisfaction of the need for relatedness one year later. Conclusions: These longitudinal findings build upon previous literature by identifying TFL as a potential managerial strategy to reduce incivility in workgroups over time. They also show that mere exposure to workplace misbehavior still impacts employees’ adjustment, suggesting that every effort to reduce deviance in workplaces are worthwhile.

Keyphrases: Transformational leadership, Incivility at work, Psychological need satisfaction, Multilevel modeling, Longitudinal assessment, Witnesses
Épisodes d’inactivité et revenus criminels dans une trajectoire de délinquance

L’instabilité de l’activité criminelle dans le temps est déjà bien documentée. On connaît toutefois peu les circonstances qui expliquent ces variations à court terme. Une meilleure connaissance de ces facteurs est souhaitable puisqu’il est possible que les transitions et les changements à court terme précèdent les points tournants des carrières criminelles. Les conditions qui rendent compte d’une interruption temporaire des activités peuvent, par exemple, contribuer à expliquer un désistement définitif. L’étude se fonde sur les trajectoires de 172 délinquants impliqués dans des crimes à but lucratif et analyse les variations mensuelles de leurs revenus criminels ainsi que les épisodes d’inactivité criminelle à l’intérieur d’une période fenêtre de 36 mois. La méthode des calendriers d’histoire de vie combinée aux modèles hiérarchiques permet d’examiner conjointement le rôle de facteurs statiques (les caractéristiques individuelles des sujets) et dynamiques (les circonstances de vie). Les résultats mettent en évidence l’importance des événements qui marquent le style de vie des délinquants et des paramètres qui caractérisent l’engagement criminel dans la compréhension des variations dans les trajectoires à l’étude. Ils soulignent également l’importance de la finalité derrière les activités criminelles pour expliquer la décision des délinquants de cesser temporaire leurs activités illicites.

Keyphrases: Performance criminelle, Épisode d’inactivité criminelle, Carrière criminelle, Circonstances de la vie conventionnelle et délinquante
Pathways to prevention: protocol for the CAP (Climate and Preventure) study to evaluate the long-term effectiveness of school-based universal, selective and combined alcohol misuse prevention into early adulthood

Background: Alcohol use and associated harms are among the leading causes of burden of disease among young people, highlighting the need for effective prevention. The Climate and Preventure (CAP) study was the first trial of a combined universal and selective school-based approach to preventing alcohol misuse among adolescents. Initial results indicate that universal, selective and combined prevention were all effective in delaying the uptake of alcohol use and binge drinking for up to 3 years following the interventions. However, little is known about the sustainability of prevention effects across the transition to early adulthood, a period of increased exposure to alcohol and other drug use. This paper describes the protocol for the CAP long-term follow-up study which will determine the effectiveness of universal, selective and combined alcohol misuse prevention up to 7 years post intervention, and across the transition from adolescence into early adulthood. Methods: A cluster randomized controlled trial was conducted between 2012 and 2015 with 2190 students (mean age: 13.3 yrs) from 26 Australian high schools. Participants were randomized to receive one of four conditions; universal prevention for all students (Climate); selective prevention for high-risk students (Preventure); combined universal and selective prevention (Climate and Preventure; CAP); or health education as usual (Control). The positive effect of the interventions on alcohol use at 12-, 24- and 36-month post baseline have previously been reported. This study will follow up the CAP study cohort approximately 5- and 7-years post baseline. The primary outcome will be alcohol use and related harms. Secondary outcomes will be cannabis use, alcohol and other drug harms including violent behavior, and mental health symptomatology. Analyses will be conducted using multi-level, mixed effects models within an intention-to-treat framework. Discussion: This study will provide the first ever evaluation of the long-term effectiveness of combining universal and selective approaches to alcohol prevention and will examine the durability of intervention effects into the longer-term, over a 7-year period from adolescence to early adulthood.

Keyphrases: Alcohol, Prevention, Universal, Selective, Combined, School, Personality
Robust regression for large-scale neuroimaging studies

Multi-subject datasets used in neuroimaging group studies have a complex structure, as they exhibit non-stationary statistical properties across regions and display various artifacts. While studies with small sample sizes can rarely be shown to deviate from standard hypotheses (such as the normality of the residuals) due to the poor sensitivity of normality tests with low degrees of freedom, large-scale studies (e.g. > 100 subjects) exhibit more obvious deviations from these hypotheses and call for more refined models for statistical inference. Here, we demonstrate the benefits of robust regression as a tool for analyzing large neuroimaging cohorts. First, we use an analytic test based on robust parameter estimates; based on simulations, this procedure is shown to provide an accurate statistical control without resorting to permutations. Second, we show that robust regression yields more detections than standard algorithms using as an example an imaging genetics study with 392 subjects. Third, we show that robust regression can avoid false positives in a large-scale analysis of brain–behavior relationships with over 1500 subjects. Finally we embed robust regression in the Randomized Parcellation Based Inference (RPBI) method and demonstrate that this combination further improves the sensitivity of tests carried out across the whole brain. Altogether, our results show that robust procedures provide important advantages in large-scale neuroimaging group studies.

Keyphrases: Robust regression, Large cohorts, Neuroimaging genetics, fMRI, Outliers
Prenatal urinary triclosan concentrations and child neurobehavior

Background: Exposure to triclosan, an antimicrobial chemical, is ubiquitous among pregnant women and may reduce thyroid hormone levels that are important for fetal neurodevelopment. Few studies have examined the association between prenatal triclosan exposure and children's neurobehavior. Objective: We investigated the relationship of prenatal urinary triclosan concentrations with children's behavior and cognitive abilities at age three years in a prospective pregnancy and birth cohort in Canada. Methods: We measured triclosan in urine samples collected at ~12 weeks of gestation in 794 Canadian women enrolled in a prospective pregnancy and birth cohort study (MIREC) from 2008 to 2011. Around age 3 years, we assessed children's cognitive abilities using the Wechsler Primary and Preschool Scale of Intelligence-III (WPPSIIII), and two scales of the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). Parents reported children's problem and reciprocal social behaviors using the Behavior Assessment System for Children-2 (BASC-2) and Social Responsiveness Scale-2 (SRS-2), respectively. Results: After adjusting for confounders using multivariable linear regression, triclosan was not associated with most of the 30 examined neurobehavioral scales. Each 10-fold increase in triclosan was associated with better WPPSI-III picture completion scores (β: 0.2; 95% CI: 0,0.5) and BASC-2 externalizing (β: −0.5; 95% CI: −1.1, 0) and hyperactivity (β: −0.6; 95% CI: −1.2, −0.1) scores, suggesting less externalizing and hyperactive behaviors. Child sex did not modify these associations. Conclusions: In this cohort, urinary triclosan concentrations measured once in early pregnancy were not associated with most assessed aspects of neurobehavior and weakly associated with a few others, but not in the hypothesized direction.

Keyphrases: Triclosan, Prenatal exposure, Child neurobehavior, Children's environmental health
Prenatal, concurrent, and sex-specific associations between blood lead concentrations and IQ in preschool Canadian children

Background: Lead exposure predicts altered neurodevelopment and lower intelligence quotient (IQ) in children, but few studies have examined this association in children who have relatively low blood lead concentrations. Objectives: To test the associations between blood lead concentrations and cognitive function in Canadian preschoolers, with a possible moderation by sex. Methods: The data were gathered from 609 mother-child pairs from the Maternal–Infant Research on Environmental Chemicals (MIREC) Study. Lead was measured in umbilical and maternal blood, and in children's venous blood at age 3–4 years. Cognitive function was measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) at 3–4 years. We tested the relationship between WPPSI-III scores and blood lead concentrations with multiple linear regression, adding child sex as a moderator. Results: Median blood lead concentrations for the mother at 1st trimester and 3rd trimester of pregnancy, and for cord and child blood were 0.60 μg/dL, 0.58 μg/dL, 0.79 μg/dL and 0.67 μg/dL, respectively. We found no association between cord blood lead concentrations and WPPSI-III scores in multivariable analyses. However, cord blood lead concentrations showed a negative association with Performance IQ in boys but not in girls (B = 3.44; SE = 1.62; 95% CI: 0.82, 5.98). No associations were found between WPPSI-III scores and prenatal maternal blood or concurrent child blood lead concentrations. Conclusions: Prenatal blood lead concentrations below 5 μg/dL were still associated with a decline in cognitive function in this Canadian cohort, but only for boys.

Keyphrases: Blood lead concentrations, Sex differences, Intelligence quotient, Canadian children
Friends with(out) benefits : Co-offending and re-arrest

Research shows that co-offending has contradictory effects on rates of re-arrest. On the one hand, group offending may be riskier: for example, co-offenders might be targeted by police or might snitch to protect themselves. Criminal networks may also have indirect effects: offenders embedded in criminal networks commit more offenses and thus should have a higher risk of being arrested at some point. On the other hand, networks generate steady criminal opportunities with relatively low risk of arrest and high monetary benefits (e.g., drug trafficking). Few authors have empirically explored the relation between co-offending and re-arrest. This paper does so, using data from seven years of arrest records in the province of Quebec (Canada). The analysis is designed to explore why some offenders are re-arrested after an initial arrest while others are not. It focuses on the factors involved in re-arrest, considering two distinct levels of measures of co-offending. The first level of analysis takes into account a situational measure that indicates whether a given offense was committed by co-offenders (group offense). The second level is used to examine whether being part of a criminal network influences re-arrest. For offenders embedded in such networks, two network features (degree centrality and clustering coefficient) show that the global position of individuals within the Quebec arrest network are analyzed. Our results suggest that co-offending is a crucial factor that should be taken into account when looking at the odds of being caught again. The use of generalized linear mixed model brings interesting nuances about the impact of co-offending. The paper adds to the recently growing literature on the link between networks and criminal careers.

Keyphrases: Co-offending patterns, Criminal networks, Re-arrest, Criminal career, Offense participation