NCube/papyrus huggingface dataset:
Inconsistencies between measures of cognitive dysfunction in childhood acute lymphoblastic
leukemia survivors : description and understanding

Objectives The frequency of cognitive difficulties in childhood cancer survivors varies according to the measurement strategy. The goal of this research is to (a) describe agreements and differences between measures of working memory and attention (b) identify contributors of these differences, such as emotional distress, affects, and fatigue.  Methods We used data available for 138 adults successfully treated for childhood acute lymphoblastic leukemia (ALL) (PETALE cohort). Working memory and attention were assessed using subtests from the WAIS‐IV and self‐reported questionnaires (BRIEF‐SR and CAARS‐S:L). Potential contributors included emotional distress, anxiety, depression (BSI‐18), affects (PANAS), and fatigue (PedsQL‐MFS). We explored measurement agreements and differences using diagnostic indices and multivariate regression models.  Results The frequencies of working memory and attention deficits were higher when using cognitive tests (15%‐21%) than with self‐reports (10%‐11%). Self‐reported questionnaires showed high specificity (median 0.87) and low sensitivity (median 0.10), suggesting they did not reliably identify positive cases on cognitive tests. We identified negative affectivity as a possible contributor to inconsistencies between self‐report and test results.  Conclusions When measuring working memory and attention in childhood ALL survivors, cognitive test results and self‐reports should not be considered equivalent. At best, self‐report may be used for screening (high specificity), but not to assess prevalence in large samples. Self‐reported difficulties are also probably influenced by the negative mood in this population.

Keyphrases: Attention, Cancer, Childhood leukemia, Cognitive test, Oncology, Self‐report, Survivors, Working memory
Changes in regional cerebral perfusion over time in idiopathic REM sleep behavior disorder

Background Idiopathic rapid eye movement sleep behavior disorder is associated with increased risk of neurodegeneration, but the temporal evolution of regional perfusion, a marker of cerebral activity, has not been characterized. The objective of the current study was to study longitudinal regional perfusion in patients with idiopathic rapid eye movement sleep behavior disorder.  Methods Thirty‐seven patients and 23 controls underwent high‐resolution single‐photon emission computed tomography. After 17 months on average, scans were repeated for idiopathic rapid eye movement sleep behavior disorder patients. We compared regional cerebral blood flow between groups and over time.  Results At baseline, patients showed lower relative regional perfusion in the anterior frontal and lateral parietotemporal cortex compared with controls. However, over time, patients showed an increase in relative regional perfusion in the anterior frontal, lateral parietal, and occipitotemporal cortex, reverting toward normal control levels.  Conclusions Patients with idiopathic rapid eye movement sleep behavior disorder showed significant areas of relative regional hypoperfusion, which disappeared over time to finally return to average levels, suggesting possible developing compensation in areas affected by neurodegeneration.

Keyphrases: Regional cerebral blood flow, REM sleep behavior disorder, Single-photon emission computed tomography, Synucleinopathy
A 2‐year dyadic longitudinal study of mothers' and fathers' marital adjustment when caring for a child with cancer

Objective Studies examining interrelationships within parental couples confronted with pediatric cancer are scarce. This study explored dyadic longitudinal associations between both partners' family functioning and mood at diagnosis, and marital adjustment 2 years later.  Method Parents of children (n = 47 couples) with acute lymphoblastic leukemia (ALL) completed the Family Well‐Being Assessment and Profile of Mood States‐Bipolar Form at diagnosis, and the Locke–Wallace Marital Adjustment Test 2 years post diagnosis. Multilevel linear models using the actor–partner interdependence model (APIM) and controlling for baseline marital adjustment were conducted to evaluate within subject and dyadic longitudinal effects.  Results For mothers, better marital adjustment 2 years post diagnosis was associated with perception of greater family support and less role conflict and role overload at diagnosis. For fathers, better marital adjustment 2 years post‐diagnosis was associated with perception of less role conflict, greater role ambiguity, and being more tired at diagnosis, as well as their partner's perception of less role conflict at diagnosis.  Conclusions These findings highlight the importance of considering both partners' perspectives in understanding marital adjustment across treatment phases in parents of children with ALL. Early interventions for couples should be tailored to meet each partner's needs in order to foster resilience within the couple.

Keyphrases: Pediatric cancer, Parents, Oncology, Marital adjustment, Family functioning, APIM
Are age and sex effects on sleep slow waves only a matter of EEG amplitude ?

Aging is associated with reduced slow wave (SW) density (number SW/min in nonrapid-eye movement sleep) and amplitude. It has been proposed that an age-related decrease in SW density may be due to a reduction in electroencephalogram (EEG) amplitude instead of a decline in the capacity to generate SW. Here, we propose a data-driven approach to adapt SW amplitude criteria to age and sex. We predicted that the adapted criteria would reduce age and sex differences in SW density and SW characteristics but would not abolish them. A total of 284 healthy younger and older adults participated in one night of sleep EEG recording. We defined age- and sex-adapted SW criteria in a first cohort of younger (n = 97) and older (n = 110) individuals using a signal-to-noise ratio approach. We then used these age- and sex-specific criteria in an independent second cohort (n = 77, 38 younger and 39 older adults) to evaluate age and sex differences on SW density and SW characteristics. After adapting SW amplitude criteria, we showed maintenance of an age-related difference for SW density whereas the sex-related difference vanished. Indeed, older adults produced less SW compared with younger adults. Specifically, the adapted SW amplitude criteria increased the probability of occurrence of low amplitude SW (<80 µV) for older men especially. Our results thereby confirm an age-related decline in SW generation rather than an artifact in the detection amplitude criteria. As for the SW characteristics, the age- and sex-adapted criteria display reproducible effects across the two independent cohorts suggesting a more reliable inventory of the SW.

Keyphrases: Slow oscillations, Aging, Sex differences, Slow waves, EEG, Sleep, Nonrapid eye movement sleep
Rapport annuel 2019-2020

Rapport annuel des activités de la Direction des bibliothèques de l’Université de Montréal en 2019-2020.

Keyphrases: Bibliothèques, Rapport annuel
La philosophie au secours des rapports de
responsabilité sociale de l’entreprise, ou comment
dépasser les limites d’un discours "aphilosophique"
sur la responsabilité. Troisième partie. Responsabilité et délibération
morale

Habermas’ ethics of discussion can be used for developing moral deliberation processes in the organizational setting. However, it can be a great challenge to put its main principles into practice, at least between internal and external stakeholders of a given organization. The Habermassian ethics of discussion avoids the trap of a priori universalization of moral norms. Nonetheless, it must also avoid implicit power games that could undermine any consensus among organizational members. We need to identify such interpretative traps that can reduce our capacity to launch an Habermassian process of moral deliberation within the organization. On the other hand, the Habermassian ethics of discussion can allow organizational members to redefine ethically focused corporate documents, especially corporate social responsibility/sustainability reports. Taking all stakeholders’ interests into account is not wishful thinking. Rather, it should imply an active and open discussion with internal and external stakeholders. The Habermassian ethics of discussion can allow organizational members to deepen the meaning and implications of their speech-acts about moral norms. L’éthique habermassienne de la discussion peut être utilisée pour déployer les processus de délibération morale en milieu organisationnel. Cependant, cela peut constituer un immense défi de mettre ses principes en pratique, à tout le moins entre les parties prenantes internes et externes d’une organisation donnée. L’éthique habermassienne de la discussion évite le piège d’une universalisation « a priori » de normes morales. Pourtant, elle doit éviter aussi les jeux de pouvoir implicites qui peuvent miner tout consensus entre les membres organisationnels. Nous devons identifier ces pièges interprétatifs qui peuvent réduire notre capacité d’initier un processus habermassien de délibération morale dans l’organisation. Par ailleurs, l’éthique habermassienne de la discussion peut permettre aux membres organisationnels de redéfinir les documents corporatifs éthiquement orientés, particulièrement les rapports de responsabilité sociale et de développement durable. Tenir compte des intérêts de toutes les parties prenantes n’est pas faire un vœu pieux. Cela devrait plutôt impliquer une discussion active et ouverte avec les parties prenantes internes et externes. L’éthique habermassienne de la discussion peut permettre aux membres organisationnels d’approfondir le sens et les implications de leurs actes discursifs au sujet de normes morales.

Keyphrases: Habermas, Jürgen, Moral deliberation, Responsibility, Philosophy, Ethics, Economics, Délibération morale, Responsabilité, Philosophie, Éthique, Économie
Psychological risk in long-term survivors of childhood acute lymphoblastic leukemia and its association with functional health status : A PETALE cohort study

Background: Recent research has suggested that long-term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes to psychological risk and which domains are most important. The aim of this study was to systematically explore which functional domain could explain anxiety, depression, and distress symptoms.  Procedure: We used data available for 105 adolescents and 182 adults successfully treated for childhood acute lymphoblastic leukemia at two Canadian sites part of the PETALE cohort. Participants were ≥5 years postdiagnosis, aged 22 ± 6 years, 52% female, and 49% acute lymphoblastic leukemia high-risk status. The contribution of health functional status (15D/16D questionnaires) to self-reported anxiety, depression, and distress (Beck scales and distress thermometer) was evaluated using adjusted logistic regression models.  Results: Prevalence rates found for mild-severe anxiety, depression, and distress were 14%, 21%, and 30% among adolescents and 27%, 20%, and 19% among adults. Frequent health domains associated with psychological risk were sleeping and breathing in adolescents, and vitality/fatigue, discomfort/symptoms, mental function, and sleeping in adults. Mental function was systematically associated with psychological risk across age groups (median OR = 10.00, 95% CI 3.01-33.71). Exploratory mediation bootstrapping analyses suggested that the effect on psychological risk of overall health status and mental function problems was partly explained by social/work/school functioning.  Conclusion: The results identified important functional health domains that could be targeted for interventions preventing psychological risk: vitality/fatigue, discomfort/symptoms, sleeping, and mental function issues. Health domains probably affect mood partly by limiting social/work/school functioning.

Keyphrases: Childhood cancer, Health status, Late effects, Psychological risk, Survivorship
Le projet GAP de la Turquie : au-delà du développement

Le Projet GAP ou «South-East Anatolia Development Project » en Turquie est l'un des vastes projets de développement au monde, consistant en la construction de 21 barrages et de 19 centres hydro-électriques sur les fleuves de l'Euphrate et du Tigre.  Toutefois, ce projet pose de nombreuses controverses au cours de la dernière décennie tant au niveau national, avec la question kurde, qu'au niveau régional, en raison de l'enjeu du partage de l'eau avec les pays voisins, notamment la Syrie et l'Irak. Néanmoins, ce sujet fut évoqué dans la plupart des cas sous l'angle exclusif de la question conflictuelle kurde.  Les objectifs de mon mémoire cherchent à comprendre l’utilisation du projet GAP par le gouvernement turc dans les constructions nationales et politiques de la Turquie de 1930 et 1980 dans un but de souveraineté et puissance nationale. Cette analyse s’effectue dans un cadre plus général de géopolitique et d’histoire politique. En s'appuyant sur des travaux en matière de géopolitique et de puissance, et surtout sur les théories de construction nationale, ce mémoire se penche sur l'évolution du projet GAP, ainsi que sur son instrumentalisation dans la construction nationale de 1930 et la reconstruction politique et nationale de 1980. The GAP or “South-Eastern Anatolia Development Project” in Turkey is one of the vast development projects in the world, consisting of the construction of 21 dams and 19 hydroelectric centers on the Euphrates and Tigris rivers.   However, this project posed many controversies during the last decade both at the national level, with the Kurdish question, and at the regional level, because of the issue of sharing water with neighboring countries, notably Syria and Iraq. Nevertheless, this subject was debated in most cases exclusively from the perspective of the Kurdish conflict issue. The objectives of my dissertation are to understand the use of the GAP project by the Turkish government in the national and political constructions of Turkey in 1930 and 1980 with the aim of sovereignty and national power. This analysis is carried out in a more general framework of geopolitics and political history. Drawn on work of geopolitics and power, and especially on theories of national construction, this dissertation focuses mainly on the evolution of the GAP project, as well as its instrumentalization in the national construction of 1930 and the political and national reconstruction of 1980.

Keyphrases: Géopolitique, Histoire-politique, Sud-Est, Puissance, Turcisme, South-East, Güneydoğu Anadolu Projesi (GAP), Nation Building, Mustafa Kemal, Turgut Özal, Geopolitics, History-politics, South-East, Power, Turquism
Prevalence of shedding and antibody to Coxiella burnetii in post-partum
dairy cows and its association with reproductive tract diseases and
performance : a pilot study

The bacterium Coxiella burnetii has been associated with reproduction disorders in dairy cattle. A cross-sectional study was conducted in Québec, Canada, to estimate the prevalence of C. burnetii in dairy cows from C. burnetii RT-PCR-positive and/or ELISA-positive herds. As a secondary objective, the associations between C. burnetii-positivity and three reproductive outcomes (purulent vaginal discharge, cytological endometritis, and success at first service) were assessed. A total of 202 post-parturient dairy cows from nine herds were sampled at 35 ± 7 days in milk. Vaginal mucus and composite milk were collected from each cow and screened for the presence of C. burnetii by real-time PCR (RT-PCR) and ELISA, respectively. Purulent vaginal discharge and cytological endometritis were evaluated using a Metricheck device and a modified cytobrush, respectively. The first insemination postpartum was done following an ovulation synchronization protocol around 70 days in milk, and success at first service was recorded. Multilevel logistic regressions adjusted for parity were used to model purulent vaginal discharge, cytological endometritis and success at first service according to C. burnetii cow status. All 202 RT-PCR-assayed vaginal samples were C. burnetii-negative. A positive result for anti-C. burnetii antibodies detection in composite milk was obtained in 25/202 samples and a doubtful result in 4/202 samples. After adjustment for sampling weights, the 202 ELISA-assayed composite milk samples gave an estimated overall prevalence of C. burnetii positive cows of 12.9 % (CI = 6.1–19.6 %) and of doubtful cows of 1.4 % (CI = 0.0–3.3 %). The proportion of ELISA-positive cows was lower in first parity (0%) compared to second (17.1 %) or third parity cows (20.0 %). The associations between ELISA positivity and reproductive outcomes were not statistically significant, perhaps due to the limited sample size, but could be used as pilot estimate for large-scale studies investigating the impact of C. burnetii infection on reproduction disorders in dairy cattle.

Keyphrases: Coxiella burnetii, Dairy cattle, Endometritis, Reproductive performance, Prevalence
La connexion au quotidien : réflexion sur nos temporalités

Dans les médias d’information, il est de plus en plus régulièrement question, recherches scientifiques à l’appui, du danger que poserait la connexion pour tous ceux et celles qui passent trop de temps branché.e.s à des appareils numériques. Une charge normative est ainsi apposée sur la connexion et le temps. Ce mémoire explore la conception de la connexion par les personnes qui la vivent et l’interrogent au quotidien. L’objectif est aussi de comprendre comment celle-ci pourrait orienter leurs expériences du temps ou comment elle pourrait être tributaire des temporalités induites par la société. La méthodologie de cette recherche exploratoire a pris la forme d’entrevues semi-dirigées menées à Montréal auprès de quatre personnes « connectées » et réfléchissant la connexion au quotidien. Nous nous rencontrions une fois par semaine pendant un mois et les participant.e.s remplissaient régulièrement un journal de bord qu’iels me présentaient ensuite, pour amorcer nos rendez-vous. À la lumière de l’analyse des transcriptions d’entrevues, je suggère que les participant.e.s ont en commun différentes approches de la dé-connexion. Cette dernière peut se conceptualiser en termes d’infrastructures, d’artefacts et de symboles. Aussi, différentes temporalités parcourent, modulent et son modulées par la dé-connexion vécue comme un moyen de s’intégrer socialement et de viser un idéal de connexion (temporellement) équilibré. Based on various scientific studies, news media discourse address more and more regularly the danger posed by connection to all of those who spend too much time using digital devices. A normative load is therefore placed on connection and time. This research project aims to: a) explore what connection means to people whose daily lives involve being connected and questioning their connection; and b) to understand how their approach to connection may orient their experiences of time while at the same time being affected by the temporalities around which today’s societies are organized.  The methodological approach that guides this exploratory research features semi-structured interviews conducted in Montreal with four “connected” people who questioned the place of connection in their daily lives. We met once a week for a month and the participants regularly filled out a logbook which they then presented to me at the beginning of each of our conversations. Based on the analysis of interview transcripts, I suggest that the participants share different approaches to dis-connection. The latter can be conceptualized in terms of infrastructure, artifacts and symbols. Also different temporalities modulate and are modulated by this dis-connection as people experience it as a means to fit in, and to aim for an ideal (time) balanced practice.

Keyphrases: Dé-connexion, temporalités, gadgets numériques, technologies numériques, débranchement, infrastructures, Dis-connection, temporalities, digital gadgets, digital technologies, un-plugging
Le pouvoir des médias et la fragmentation identitaire dans les oeuvres de Larry Tremblay

Plusieurs études ont déjà relevé la place singulière qu’occupe le personnage dans la dramaturgie de Larry Tremblay. Les œuvres de cet auteur québécois regorgent effectivement d’individus tourmentés par l’environnement dans lequel ils évoluent. Durant les 20 dernières années, la thématique des médias a particulièrement été l’objet de l’attention de l’auteur. En créant des pièces ayant comme centre l’univers médiatique, Larry Tremblay entreprend de poser un regard critique sur cet aspect important touchant la société actuelle. Dans le cadre de ce mémoire, l’objectif est donc d’étudier plus spécifiquement les différents personnages du dramaturge lorsque ceux-ci sont placés dans des contextes où ils sont envahis par les médias. Il s’agira de montrer comment le dramaturge expose les effets néfastes du pouvoir des médias en abordant la question du regard, de la banalité, du vide, du narcissisme ainsi que de la désillusion marquant l’époque contemporaine. L’analyse des œuvres Ogre (1995), Téléroman (1997) et Grande écoute (2015) permettra de montrer que c’est par l’intermédiaire de personnages dont l’identité se morcelle et se transforme, que Larry Tremblay expose les conséquences les plus importantes qu’entraine la société médiatique sur l’individu. L’objet de ce mémoire est de saisir l’évolution de la pensée de l’auteur à l’égard des médias et de comprendre comment ses personnages ont évolué au fil du temps parallèlement au domaine médiatique. Many studies have already examined the singular place occupied by the character in Larry Tremblay’s dramaturgy. This Quebec author’s works are filled with many individuals who are deeply affected by the environment they live in. For the past 20 years, the playwright’s particular interest in the theme of media has been observed. By creating plays in which the media are at the forefront, Larry Tremblay takes a critical look at an important aspect of current society. In the context of this thesis, the objective is therefore to study more specifically Tremblay’s characters who are in environments pervaded by the media. In order to show how the author exposes the negative impacts of the power of the media, we will address the question of the gaze, the banality, the void, the narcissism, as well as that of the disillusion that touches our time. The analysis of Ogre (1995), Téléroman (1997) and Grande écoute (2015) will demonstrate that it is through characters whose identity is crumbling and changing that Larry Tremblay denounces the most disastrous consequences stemming from the media for individuals. The purpose of this thesis is to grasp the evolution of the author’s thought regarding media and to understand how his characters have evolved over time alongside the media.

Keyphrases: théâtre contemporain, médias, télévision, étude du personnage, narcissisme, banalité, Larry Tremblay, narcissism, Larry Tremblay, contemporary theatre, media, character, narcissism, banality