MurphyA/hacker-news huggingface dataset:
by maximz | 2026-01-02 16:29:49+00:00
Immunera | Principal Machine Learning Engineer | NYC area (hybrid) | Full-time | immunera.ai

Hey! I’m Maxim, cofounder/CEO of Immunera.

We're building blood tests that use gene sequencing and machine learning to help patients with autoimmune disease. Immunera spun out of years of research at Stanford, and our technology has been published in Science and covered by The New York Times.

We're hiring a Principal Machine Learning Engineer to shape the core models and infrastructure that power our blood tests. We are partnering with hospitals to generate training data from real patients for our language models and other biological sequence models.

This is a senior engineering role with significant autonomy at an early-stage, venture-backed startup. We're looking for strong experience building and operating ML systems in production (Python, PyTorch/TensorFlow, cloud platforms). Prior biology or healthcare experience is NOT required; we care much more about your ability to reason about data, models, and systems.

Full JD: https://www.immunera.ai/jobs

Contact: maxim@immunera.ai (subject: “HN ML job”)
by RiverCrochet | 2026-01-02 16:29:50+00:00
Incorrect. Previously at least some lip service consideration to public benefit was given.

Television, for example, had many FCC regulations at its inception to ensure it served in the public interest. This of course devolved over time into nomimal compliance like showing community bulletins at 5am when no one was watching.

You might be somewhat correct with the release of the Internet upon the public in the early 90's, but imagine if common carrier rules were not in effect for the phone lines everyone was using to access the Internet back then. The phone companies would have loved to collect the per-minute charges AOL initially was doing before they went to unlimited. They already had a data solution in place - ISDN - but it was substantially more expensive from what I understand and targeted to business only.

With AI, it's the complete opposite, everything is full steam ahead and the government seems to be giving it its full blessing.
by Ukv | 2026-01-02 16:30:18+00:00
> The issue is that the kid wants to play a game with his friends [...] This is a clear and meaningful distinction and it doesn't sound supported.

Clear how it could allow friends-only when connecting directly to another Nintendo Switch user, but a bit murky how it'd make that determination in cases like Minecraft where the client is connecting to a cross-platform user-hosted game server that is not associated with any Nintendo/Microsoft account.

Could work if you have the parents manually whitelist specific server IPs, as they could with router/firewall, though not sure if "could you whitelist 209.216.230.207 please?" would be a meaningful choice in most cases.
by ryandrake | 2026-01-02 16:30:53+00:00
I can't seem to ween myself off of reliance on Quicken. I really want to, and I hate that I am tied to Intuit software. I hate that every transaction I've made since 2000 is stored in a proprietary binary blob.

But I can't find an alternative that has cracked the killer feature: Syncing with each of my online accounts. I like to track every expense and every transfer down to the penny, and then update from the bank's online connection to confirm each of them. I do this daily so I can catch any fraud or mistakes. I have 27 accounts tracked, and I'm simply not going to log in to each of them using their janky web sites, download CSVs, and import them manually into personal finance software. It's just not going to happen. Quicken's support for this is far and away the best out there.

Doing this all in plaintext and copy/pasting from downloaded CSVs every day seems like an absolute nightmare.

Unfortunately, the trend seems to be banks turning down their public-facing OFX services, and instead moving to the model where Intuit is the middleman and you need to tether yourself to them, who in turn channel your requests to the banks. So it's been getting even more and more difficult to escape from Quicken.
by throw0101d | 2026-01-02 16:31:43+00:00
> Certainly, if the objective is (merely) security for one's children, that can be secured with much (much) less money (and likely was secured in the secondary that the author makes reference to); […]

See perhaps Nick Maggiulli's post "The Ideal Level of Wealth":

> Financial Independence (28.6x Your Annual Spending): $3.5M. Assuming you never wanted to work again, you would need about 28.6x your annual spending to cover your costs indefinitely [$120,000 * 28.6 ~ $3,500,000]. This 28.6 comes from the Kitces research[1] showing that the 3.5% Rule[2] is the safe withdrawal rate for a 40-year time horizon and beyond. This research suggests that if you can make it 40 years while withdrawing 3.5% per year, then you’ll likely make it 50 years (or more).

[…]

> Whether your goal is Coast FIRE or full financial independence, the ideal level of wealth in the U.S. is in the low-to-mid range of Level 4 ($1M-$10M), or $2M-$5M. I know this is a lot of money and many people will never reach it, but that’s why it’s an ideal. It’s something to strive for. It’s enough where you don’t have to worry about money anymore, but not so much that it becomes a burden or warps your identity.

* https://ofdollarsanddata.com/the-ideal-level-of-wealth/

Adjust the $120k annual spend for your own lifestyle and cost of living.

You're not going to fly private, but it will take most of the worry out of life. Morgan Housel, author of the recently release The Art of Spending Money (and previously The Psychology of Money):

> 00:50:16 […] You have the independence to be who you are and wake up every morning and say, I can do whatever I want today. That’s wealth.

* https://ritholtz.com/2025/11/transcript-morgan-housel-spend/
by mrjay42 | 2026-01-02 16:31:48+00:00
Contrary to some other comments: no, IPV6 hasn't taken over the world at all.

In my case, I administrate a small server at home, where I self host many services that are made available to myself, friends and families, over the internet.

In that context, IPv6, is SADLY (please note that I have NOTHING against IPv6), a limitation, even a nightmare to use.

Some programs do not handle IPv6 at all. Game servers for instance, do not support it, the one that I think about is: Arma 3. But there are many others

In 2025 (and 2026 too?), 4G (5G?) operators do not all route over IPv6 -> which means that if your domain only has a AAAA record, some people using 4G will not be able to access ANY of your services. This issue forced me to beg my ISP to obtain an IPv4 "fullstack" as they call it.

Without that IPv4 you have to go through some kind of tunneling (like Cloudflare) -> and guess what? Cloudflare sometimes crashes (it happened super recently remember?) and in that situation -> ALL your services accessible through the tunnel are "down" for your users. Plus, it is EXTREMELY unsatisfying to rely on an external private-owned service for a selfhosting project.

In almost ALL context IPv6 is seen as optional, additional, additional configuration and is NEVER the default. NEVER. Which means: more configuration, possibly more struggle.
by kstrauser | 2026-01-02 16:31:59+00:00
It’s ok to understand something and disagree with it. It’s another to proudly wear ignorance on one’s sleeve. That’s never a good look.

There’s no way in which IPv6 is less private than IPv4. An ISP issues your house an IPv4 address and an IPv6 /48 network. Both of those can be subpoenaed equally. The privacy extensions work as advertised.

And in reality land, the big companies are the ones pushing for the upgrade because they’re the ones hardest hit by IPv4’s inherent limitations and increasing costs. Same rando in Tampa isn’t leading the charge because it doesn’t affect them much either way.
by ErroneousBosh | 2026-01-02 16:32:06+00:00
> Is there a way to "undo" motion blur and get a sharp picture?

Not really, no, any more than there is a way to unblur something that was shot out of focus.

You can play clever tricks with motion estimation and neural networks but really all you're getting is a prediction of what it might have been like if the data had really been present.

Once the information is gone, it's gone.
by michaelmrose | 2026-01-02 16:32:11+00:00
If your kid lies you might not get a truthful answer to that question in person or online.

You are actually expecting a lot from devices that you never had in the real world in the first place in order to mitigate a risk that is very scary but less likely to kill them than drugs and alcohol, swimming, bad driving, biking, getting hit by a car whilst walking, getting shot, or suicide.

People are freaking out over stranger danger not because it is by the numbers prevalent but because they feel like they can control it then find out the controls suck.

What if I started Bikesafe an always online dash cam / coach for your rider where AI would identify unsafe behaviour and coach your kid and virtually eliminate bike deaths. Would you feel more safe?

What if you read again and again that it didn't work because of how many accidents are caused by drivers or momentary mistakes.

Would you feel only as unsafe as before or worse?
by ljm | 2026-01-02 16:32:27+00:00
One of the most frustrating and perhaps thought-terminating clichés on the internet and social media at large is alluded to in this reply:

“I personally could not view this page [because I turned off JS], therefore I will dismiss it out of hand as it didn’t cater to my needs.” A choice made by the consumer somehow makes the author accountable for it.

Or more succinctly, “but what about me [or people I’ve anointed myself as spokesperson for]?”spoken by someone not the intended audience for the piece, trying to make the author responsible for their need.

The answer to which, I think, is either, “it’s not for you then so move on,” or perhaps even “misery is optional, just enable JS ffs.”

The idea that the creator of a work must bend to the will of those that consume it seems to be highly prevalent, and is pretty much at odds with creativity itself.
by podgorniy | 2026-01-02 16:32:54+00:00
> What exactly is wrong with Americans or for the most part the rest of the world valuing economic performance as a measure of prosperity and progress?

Prosperity of the nation? Or average people of the nation?

Imagine economy grows. But created value is distributed in hands of few. How then we think about prosperity? It is a prosperity of those few not a nation's?
by sowbug | 2026-01-02 16:33:20+00:00
Even inside of EU, seemingly BYD have reasonable prices, especially compared to their EU competitors.

This will usually be the case, because domestic manufacturers raise prices once tariffs (import taxes) on foreign manufacturers are imposed.

This is also why import taxes are so hard to eliminate once they're introduced: domestic manufacturers get used to the gratuitous revenue cushion, and the government gets used to the gratuitous tax cushion. Meanwhile consumers wonder why everything has gotten so expensive.
by esrauch | 2026-01-02 16:33:54+00:00
In practice mutation fuzz testers are able to whitebox see where branches are in the underlying code, with a differential fuzz test under that approach its generally able to fuzz over test cases that go over all branches.

So I think under some computer science theory case for arbitrary functions its not possible, but for the actual shape of behavior in question from this library I think its realistic that a decent corpus of 'real' examples and then differential fuzzing would give you more confidence that anyone has in nearly any program's correctness here on real Earth.
by iso1631 | 2026-01-02 16:34:33+00:00
You can nat all your ipv6 traffic behind a single IP if you want. Or a new IP for every connection.

Realistically though there's enough fingerprinting in browsers to track you regardless of your public IP and whether it's shared between every device in the house or if you dole out a routable ipv4 to every device.

CG-NAT gives more privacy benefits as you have more devices behind the same IP, but the other means of tracking still tend to work.

For me I just don't see the appeal of supporting both ipv4 and ipv6. It means a larger attack surface. Every year or two I move onto my ipv6 vlan and last a few hours before something doesn't work. I still don't see any benefit to me, the user.
by Ekaros | 2026-01-02 16:34:51+00:00
It is very confident in producing first output. Confidence works on lot of people. And then well there is lot of demand for good enough looking content. Be it email, easy answer or art. Or translation.

I can actually see value in AI generated content with stuff that is already considered low value. Slap a image on your spam post. Hell, just write that spam post. Do that enough time and you might make more than you spend in time and money.

Seems like on net for individuals doing this there is some value on it.
by torginus | 2026-01-02 16:35:11+00:00
Can they? I can get a lot of car for that money if I buy something used that's just a few years old, and I'll have a fairly good idea how to get my car serviced and how much it will cost, and how much I'll be able to sell it for.

Even if we don't consider these things, here in the EU, very few Chinese models look like a steal.

Tariffs or not (PHEVs and ICE cars are not tariffed like EVs afaik), the consensus seems to be that Chinese cars at a given category, are built better, cost like 10-20% less, are well equipped, but generally drive worse and often have annoying usability issues

All things considered, they're certainly competitive depending on what you're looking for, but don't look likely to oust the existing competition.

And I don't get the West's obsession with BYD - imo they look weird, they either get the interior or exterior styling wrong (with the notable exception of the Seal U), and aren't really selling that well compared to other Chinese brands.
by d4mi3n | 2026-01-02 16:35:21+00:00
Unless my understanding of how IPv6 is flawed, I don’t think your assertion is true in practice. One of the big benefits to IPv6 is that addresses are plentiful and fairly disposable. Getting a /48 block and configuring a router to assign from the block is pretty straightforward.

I’m aka unsure if IPv4 really gets you the privacy advantages you think it does. Your IP address is a data point, but the contents of your TCP/HTTP traffic, your browser JS runtime, and your ISP are typically the more reliable ways to identify you individually.
by Auhrii | 2026-01-02 16:35:42+00:00
Location: Doncaster, UK
Remote: Yes
Willing to relocate: No
Technologies: HTML, CSS, JavaScript, Node.js, PHP, MySQL, C#, Lua(u), Python
Résumé/CV: https://auhrii.dev/CV.pdf https://www.linkedin.com/in/auhrii/
Email: violet@auhrii.dev

On-site is an option in Doncaster and Scunthorpe.

Self-hosting full stack developer and hobbyist game developer. Relatively inexperienced in professional/corporate settings and with frameworks (this one owing to the limited compute of my server and a preference for portability), but I can learn and get up to speed quickly. I will not touch generative AI outside of an academic context.
by throwway120385 | 2026-01-02 16:35:54+00:00
This is just generally true even as an adult. A lot of social events used to start out on text threads in the early 2000's and then moved on to Facebook Calendar by the mid 2000's and then Instagram and I don't even know how it would work now. But if you wanted to be in any particular social group you probably had to deal with the icky features of all of these social media apps just to do that. We needed a public square for our little villages everywhere and instead we got a man screaming at clouds and occasionally handing out invitations.
by Beretta_Vexee | 2026-01-02 16:35:55+00:00
"Liberation of the Freebox", A slightly crazy Frenchman embarks on a quest to find exploit and write a complex exploit chain, using PrDoom and the Linux HFS+ driver to gain root privileges on his set-top box. All this in order to unlock the recording of somewhat rubbish TV channels such as TF1 and M6.

And he waited almost ten years and the retirement of the hardware to reveal it because he didn't want it to be patched.

If you are into hardware emulation "From silicon to Darude sand-storm" is fun.

the https://media.ccc.de/v/39c3-from-silicon-to-darude-sand-stor...
by tuetuopay | 2026-01-02 16:36:06+00:00
I'm not. The situation is improving rapidly, and I'd expect the gap to close soon.

I still have the windows install. And with an RTX 3090, framerate is not that much of a consideration for most games, especially since my main monitor is "only" 1440p, albeit a 144Hz one.

Couple that with GSync, framerate fluctuations is not really noticeable. Gone are the days where dipping below 60Hz is a no-no. The most important metric is stutter and 1% lows, those will really affect the feeling of your game. My TV is 120Hz with GSync too, and couch games with a controller are much less sensitive to framerate.

Do I leave performance on the table? Surely. Do I care? In the short term, no. The last GPU intensive games I played are Hogwarts Legacy and Satisfactory, both of which can take a hit (satisfactory does not max the GPU, and Hogwarts can suffer DLSS). The next intensive game I plan on playing is GTA VI, and by this time I'd fully expect the perf gap to have closed. And the game to play fine, given how Rockstar puts care on how the performance of their games, more so with the Gabe Cube being an actual target.

In the long run, I agree this is not a "happy" compromise. I paid for that hardware dammit. But the NVIDIA situation will be solved by the time I buy a new GPU: either they completely drop out of the gaming business to focus on AI, or they fix their shit because Linux will be an actual gaming market and they can't keep giving the finger to the penguin.
Building an OS from scratch, need your opinion on volume names
by C_IsTheGOAT | 2026-01-02 16:36:40+00:00
Hello,

I’m programming my own operating system completely from scratch (not Linux-based), and I’d like to ask you a question:
What is your preferred volume naming scheme?

Do you prefer something similar to Windows (C:, D:, etc.), or more like Linux (sda1, etc.)?

I genuinely respect your preference and care about your opinion, who knows, you might even use my OS in the future once I finish developing it!

Thanks bro.
by hasperdi | 2026-01-02 16:37:14+00:00
In 2025 I started managing my small business finances using hledger (started with beancount, but got confused with missing packages in the new version). I use Claude Code to help me enter transactions eg from pdf receipts and to ensure the books are balanced. It's quite a pleasant experience I must say, as I find accounting tedious / not my cup of tea
by kstenerud | 2026-01-02 16:37:57+00:00
Basically, for better or worse JSON is here to stay. It exists in all standard libraries. Swift's codec system revolves around it (it only handles types that are compatible with JSON).

It sucks, but we're stuck with JSON. So the idea here is to make it suck a little less by stopping all this insane text processing for data that never ever meets a human directly.

The progression I envisage is:

1. Dev reaches for JSON because it's easy and ubiquitous.

2. Dev switches to BONJSON because it's more efficient and requires no changes to their code other than changing the codec library.

3. Dev switches to a sane format after the complexity of their app reaches a certain level where a substantial code change is warranted.
by mystraline | 2026-01-02 16:38:19+00:00
In reality, the whole "stranger danger" is way overblown and always has been. Most of the time, sexual predators are going to be either family or friends.

https://rainn.org/facts-statistics-the-scope-of-the-problem/...

93% of victims under 18 know their abuser.

Sure there's 7% thats not, but a significant supermajority is family/friends. 59% were acquaintances, and 34% are family.

Edit: seriously, -1 cause I link to actual facts, rather than shitty emotional outbursts? Family and friends of family have always been the major list of suspects for child sex abuse. They're the ones who have time and access.

But somehow linking to cited facts is -1 central. Sigh.
by nirvdrum | 2026-01-02 16:38:35+00:00
I'd encourage you to read the HN guidelines, linked in the site footer:

https://news.ycombinator.com/newsguidelines.html

Repeatedly, you've been dismissive and insulting. It's not conducive to productive conversation. Your characterization of what I do or how I work is wrong. You latched on to some small part you thought would let you "win" and ran with it. If you actually care, I do a lot of open source work so you can find exactly how I work. Naturally, you can't see what I do in private, but I assure you it's not significantly different.

I aim to ship reasonably complete functionality. The "V" in "MVP" means it needs to be viable, not just minimal. Shipping some part that doesn't work standalone isn't useful to anyone. Yes, the PR is smaller, but now the context for that work is split over multiple PRs, which may not be reviewed by the same people. No one really has the full picture beyond me, which I guess is a good way to get my PRs rapidly approved, but a terrible way to get feedback on the overall design.

I don't work with you so I don't particularly care how you work. Again, I was offering up other solutions than running "git commit" every 15 minutes. If you want to manually simulate filesystem snapshots, that's your prerogative. But, you're incorrect that any model other than the one you employ is niche an not how software is written. Elsewhere you dismissed the examples of large, open source projects as being unique. But, you'll find substantially smaller ones also employ a model closer to what I've described.
by frumenty | 2026-01-02 16:38:39+00:00
I don't think that's what the summary is saying.

My reading of the following is that the cost of each additional quality adjusted life year would be over $100,000, rather than that each vaccination prompts $100k in economic value

> Including preadolescent boys in a routine vaccination programme for preadolescent girls resulted in higher costs and benefits and generally had cost effectiveness ratios that exceeded $100 000 per QALY across a range of HPV related outcomes, scenarios for cervical cancer screening, and assumptions of vaccine efficacy and duration
by JeremyNT | 2026-01-02 16:39:42+00:00
My daughter has always used a normal low end Android phone with the default parental controls. She only installs what I whitelist. It's really not that much effort.

Honestly, maybe the Gabb Phone marketing is lulling users into a false sense of security. If you still have to do the same legwork as the default Android experience, what's the point of their devices?
by maxglute | 2026-01-02 16:39:42+00:00
Consider PRC has 90%+ home ownership rate and declining population, i.e. almost every person in PRC is functionally going to inherit a house, likely multiple, the floor for stability is going to be much higher. This is not west where high % of population is one paycheck away from eviction. Worst case scenario for PRC youth is to have roof over head. Worst case scenario for PRC elderly is they die 100s of times more materially affluent than any past Chinese. VS west deals with onerous social safety nets that's increasingly unsustainable, old gen will lose benefits while new gens finance and live worse off then old gens... because everything is financialized, something CCP very keen to guard against... because it regulates capitalism. IMO very different scale instability to govern for.
by pfannkuchen | 2026-01-02 16:40:16+00:00
Consider that demand for food delivery is not constant throughout the day and night.

I believe throughput would actually be reduced every time demand increases, which would happen in the morning, at various meal times, around the different opening and closing times of various restaurants, etc.

I do agree that the throughput reduction would be more complex than “1 driver sits idle for <delay time> every 1 order”.