MurphyA/hacker-news huggingface dataset:
by net01 | 2026-01-06 21:51:30+00:00
i remember reading about "lumina probiotic" Has anyone done research on it since, reviewing thier claims ?

their claims on their website:

replaces S. mutans, alters oral microbiome, reduces acid via ethanol metabolism, produces antibiotic, freshens breath, brightens teeth, lasts decades. etc

i am very skeptical of it
by simonw | 2026-01-06 21:52:22+00:00
Alarmingly well! https://gisthost.github.io/?1bf98596a83ff29b15a2f4790d71c41d...

It couldn't quite beat the Rust implementation on everything, but it managed to edge it out on at least some of the benchmarks it wrote for itself.

(Honestly it feels like a bit of an afront to the natural order of things.)

That said... I'm most definitely not a Rust or C programmer. For all I know it cheated at the benchmarks and I didn't spot it!
by notepad0x90 | 2026-01-06 21:52:47+00:00
But why? I routinely see typos and grammar errors on major news articles. LLMs catch that stuff really well, it's like the one thing they're good at. They can be as opinionated as humans on the subject. Perhaps sycophantic mainstream models might be to eager to please, but that's not an issue with the tech itself. I like to think that every publication that is using LLMs to write content has also replaced copyeditors/writers with them.
by godelski | 2026-01-06 21:53:17+00:00
While I don't use the AI part I have a very similar scheme and it is one of the reasons I encourage people to live in the terminal.

The idea is to create a modern "terminal"[0]

My main computer is a Macbook Air, which I carry around with me. It's purpose is for: internet, using Microsoft products when I'm forced to, Zoom/meetings, and SSH (or Mosh).

Most of my work is not done on this Macbook, instead I use it mostly as a terminal. I have a desktop that's sitting behind my TV so that it can be my TV and gaming system (yeah I know Monitor > TV. I'm a filthy casual and I don't care). I have a mouse connected to that computer and instead of using a keyboard I use ydotool (Wayland xdotool) with a shortcut on my iPhone or a script on my android phone or from my Macbook. I don't have to get up from the couch and I don't need a clunky wireless keyboard to clutter my livingroom.

Additionally I have a few pis and an old android phone with Tailscale installed on them. That's come in handy before as a machine's been disconnected and so I couldn't ssh from outside. Also makes it really easy to do a jump if you want to keep a machine off Tailscale or you don't have full control (like my 3D printer).

This setup is very natural feeling if you live in the terminal. I actually started doing this when I started doing HPC work. In a setting like that you're never sitting in front of the computer you're doing most of your work on so it kinda clicked "why was I restricting myself outside work?" Plus there's the side benefits of I always have access to my media, tools, and other stuff. You can do exactly the same thing with a phone but I like having a keyboard and the air is very lightweight and has a long battery life. Any netbook would have done the job tbh.

[0] There's a reason they're called "terminal emulators" rather than just "terminals".
by SirensOfTitan | 2026-01-06 21:53:20+00:00
Only tangentially relevant, but I’ve dealt with mouth and gut microbiome issues my whole life, the latter exacerbated by a strong antibiotic I had to go on in mid 2017 for a super resistant staph infection. L Reuteri supplementation and “L Reuteri yogurt” was one of those alternative methods I read about (though I’m skeptical that reuteri is the dominant strain in this “yogurt”)

Doctors don’t really care to look at these kinds of issues. It took years of suffering and autoimmune issues (particularly muscle spasms and joint pain) alongside gut problems before I demanded a gastroenterologist test me for H pylori and SIBO: I was positive for both.

H pylori was a painful treatment process, but I cleared it after one round of quad therapy. SIBO on the other hand, a condition I think we hardly understand, has been hard to deal with. Many rounds of rifaximin with very minimal relief and no real answer as to how to deal with it.

Doctors are hesitant to help, so I’ve resulted to a lot of personal experimentation to deal with it. The only thing that ever worked (and it’s just anecdata so unsure) was sulbultiamine supplementation, but I can’t actually get that anymore and normal thiamine doesn’t help.

This is all to say: I think microbiome is supremely important to health, very few things seem to really impact it, and doctors are hesitant to deal with these systems at all. I’m sure FMTs will become much more popular for a variety of conditions, but it seems like it’s a real risk where not only might someone else’s microbiome not be a fit for your physiology, but you could be inheriting a variety of risks the donor is susceptible to but you are not.

I am not a doctor and much of what I’m saying may be wrong. Don’t quote me please.
by notahacker | 2026-01-06 21:53:49+00:00
In fairness, Astro Mechanica and Hermeus claim to have a pathway to Mach 5. Not saying I expect to see it, particularly not for regular people flights to the Middle East, but believing in it is kind of the premise of the article.

(I must admit I was more curious about Astro Mechanica's engine tech before they also threw in the intention to operate Uber for business jets...)
by hairofadog | 2026-01-06 21:53:51+00:00
I'm finding it hard to imagine a scenario in which this version of the United States would go to war to protect Europe, and I have little doubt that Putin and Trump have a handshake deal in which each will let the other carve up its neighbors. Putin gets Ukraine and Eastern Europe, Trump gets Greenland and parts of Central and South America. As much as I don't want it to be true, I believe NATO is dead.
by codyb | 2026-01-06 21:54:13+00:00
I believe we should judge folk based on their actions not their gaffes personally.

Under Biden the US reduced inflation faster than any other peer country, reduced student loan debt by billions, secured 1 trillion in mostly green infrastructure investment, secured 500 billion in semiconductor manufacturing, had a low 4% unemployment rate, helped with the NATO expansion, supported Ukraine, fought for consumer protections, expanded transgender rights and visibility, and so much more.

Literally the most successful president in my lifetime, and all I hear is people tell me about how he couldn't do his job.

It just, doesn't mesh with reality. What it does mesh with is the messaging that's been pounded pounded pounded through everyone's heads for the last four years though.

Of course anyone trying to refute 15 lies in 60 seconds while actually performing the duties of his job (instead of say... tweeting, golfing, and calling women derogatory names while fostering hate, and rewarding sycophants with insider trades and contracts) and then also make their own point is going to fail.

Lots more people than Biden, who're a lot more physically fit would fail at debating serial liars and thugs like Trump.
by axus | 2026-01-06 21:54:27+00:00
I'm OK with anyone expressing their feelings on Kapersky, Ellison, Musk, their boats, and their politics. My guess is that throwaway has similar feelings about all three.

Personally I do feel that we share guilt proportional to our contributions to the ones hurting others; and I'd be interested in the calculus of their respective moral burdens. My tax payments mean I bear 0.0000001 % of the responsibility for US government behavior.
by the_af | 2026-01-06 21:54:28+00:00
> Is your position that if someone commits a coup, some other country or the international community can't go in and uninstall that person from power?

I find the assumptions behind your question fascinating.

Where did I say anything about what a country can or cannot do? A country can do whatever its military might and ability to absorb repercussions allows it to do.

This is completely unrelated to whether the path the country does decide to take constitutes an act of war or not.

If you're asking me whether I like that the US is playing world police and deciding who must face the law, and take them by force anywhere in the world, weeeell... let's say it's really messy to try to justify the US when it supports some coups, some dictators, and some brutal regimes, but acts against others, and the overall rule seems to be "if they play ball with the US it's ok, if they don't then war".

A small consolation is that the US is seemingly stopping their horrifying practice of extraordinary renditions and torturing suspects abroad, outside the scrutiny of US society and institutions. I think that was Bush era, but maybe it persisted during Obama too.
by tgsovlerkhgsel | 2026-01-06 21:54:54+00:00
Android is slightly less horrendous but still bad - probably because at least in some markets enough people have low end phones that size does somewhat matter. I suspect Uber made optimizing app size a priority once they realized that their 1 GB behemoth was hovering on the top of the "things you can delete instead of your wedding photos if you want to be able to continue to use your phone" list, and they were losing customers over it. But there are still apps that are hundreds of MB with no valid reason to be that fat.

Meanwhile, well-written browsers - which are essentially whole operating systems - are in the dozens, so this is 100% bloat.

There simply is little incentive to optimize apps for size, because someone else pays the price and there is little consequence for making it big. Slapping another data collection or ad SDK into the app is easy and free.

If the EU was serious about it, it would consider it part of the ecodesign rules since it forces people to buy new phones for more storage much earlier than needed.

If the app stores were serious about it, they'd either re-introduce the hard cap and stick to it, or at least show the size prominently. Or start charging fees for bloaty apps. At least on the mobile version of the Play store, I don't think you can even see the app size without starting an install - let alone search or filter by it. It's as if they want to encourage bloat.
by fragmede | 2026-01-06 21:56:31+00:00
Why does it matter? If it works, it works, no? Or are we now artisanal hipsters, where the code is better if it was hand-typed on a really shitty keyboard where the N key sticks, and it just feels better using the software because of how much pain the coder in the forests outside of Portland experienced while writing the code. Do we need an international fair trade organization to make sure the code was ethically sourced?
by sfink | 2026-01-06 21:57:04+00:00
> you want to keep users hooked to extract some value from them

Ironically, that's what I initially liked about the daily puzzles like Wordle: they forcibly prevented you from sinking too much time into them. It was sort of like, "hey here's something cool, and I'm going to make sure it's a positive addition to your life by preventing you from succumbing to your own addictive impulses". You could call that condescending or infantilizing, but to me it's just part of the look and feel of a thing. Especially if the author isn't charging money, they get to use whatever tools are at their disposal to craft the users' experience of it. Wordle Over And Over Again is a different game than Wordle Once Daily. (And WOAOA done properly would probably have a progression of difficulties, or themes, or something, whereas WOD makes more sense with pure randomness.)
by giancarlostoro | 2026-01-06 21:57:32+00:00
This is how Beads works, especially with Claude Code. What I do is I tell Claude to always create a Bead when I tell it to add something, or about something that needs to be added, then I start brainstorming, and even ask it to do market research what are top apps doing for x, y or z. Then ask it to update the bead (I call them tasks) and then finally when its got enough detail, I tell it, do all of these in parallel.
Ask HN: Do you write things down for your future self? If so, how?
by mcsgroi | 2026-01-06 21:57:40+00:00
I have been thinking about how often I wish I remembered what I was thinking at an earlier point in time.

Not just what decision I made, but the reasoning behind it, the assumptions I was operating under, or the message I would have wanted to leave for myself once more time had passed.

I sometimes write notes, but they usually capture facts or outcomes, not my thinking. When I come back later, the context is missing, and it is easy to second guess decisions that actually made sense at the time.

I am curious how others approach this.

Do you write down decisions or reasoning explicitly?
Do you leave notes or messages for your future self?
Do you ever revisit past thinking intentionally, or do you mostly let it go?

I am exploring a small personal tool focused on recording thinking and returning it later, but I am more interested in how people already handle this today.
by soulofmischief | 2026-01-06 21:57:43+00:00
Opus 4.5 is currently helping me write a novel, comprehensive and highly performant programming language with all of the things I've ever wanted, done in exactly my opinionated way.

This project would have taken me years of specialization and research to do right. Opus's strength has been the ability to both speak broadly and also drill down into low-level implementations.

I can express an intent, and have some discussion back and forth around various possible designs and implementations to achieve my goals, and then I can be preparing for other tasks while Opus works in the background. I ask Opus to loop me in any time there are decisions to be made, and I ask it to clearly explain things to me.

Contrary to losing skills, I feel that I have rapidly gained a lot of knowledge about low-level systems programming. It feels like pair programming with an agentic model has finally become viable.

I will be clear though, it takes the steady hand of an experience and attentive senior developer + product designer to understand how to maintain constraints on the system that allow the codebase to grow in a way that is maintainable on the long-term. This is especially important, because the larger the codebase is, the harder it becomes for agentic models to reason holistically about large-scale changes.

If left to its own devices, Opus 4.5 will delete things, change specification, shirk responsibilities in lieu of hacky band-aids, etc. You need to know the stack well so that you can assist with debugging and reasoning about code quality and organization. It is not a panacea. But it's ground-breaking. This is going to be my most productive year in my life.

On the flip side though, things are going to change extremely fast once large-scale, profitable infrastructure becomes easily replicable, and spinning up a targeted phishing campaign takes five seconds and a walk around the park. And our workforce will probably start shrinking permanently over the next few years if progress does not hit a wall.
by mjasny | 2026-01-06 21:58:22+00:00
Thanks a lot for the kind words, we really appreciate it!

Regarding your questions:

1) Yes. If you want to take advantage of IOPOLL while still handling network I/O, you typically need two rings per thread: an IOPOLL-enabled ring for storage and a regular ring for sockets and other non-polled I/O.

2) They are not mutually exclusive. SQPOLL was enabled in addition to IOPOLL in the experiments (+SQPoll). SQPOLL affects submission, while IOPOLL changes how completions are retrieved.

3) The main trade-off is CPU usage vs. latency. SQPOLL spawns an additional kernel thread that busy spins to issue I/O requests from the ring. With IOPOLL interrupts are not used and instead the device queues are polled (this does not necessarily result in 100% CPU usage on the core).

4) Yes. For a modern DBMS, a thread-per-core model is the natural fit. Rings should not be shared between threads; each thread should have its own io_uring instance(s) to avoid synchronization and for locality.
by laughing_man | 2026-01-06 21:58:28+00:00
>History is full of such examples. IBM thought nothing much of the software layer that ran their PC hardware layer and happily allowed Microsoft to own the OS market.

IBM didn't "happily" do anything of the sort. The company was undergoing multiple anti-trust investigations at the time and was trying to avoid incurring a large fine or even a structural remedy for creating a vertical monopoly.

The reason Microsoft went to the mat so hard when the government was trying to separate IE from Windows was Gates' fear that the company would end up being similarly crippled by the specter of anti-trust action from the government.
by samuell | 2026-01-06 21:58:44+00:00
Nice experiment and writeup!

On a tangent, nice to see Plasmidsaurus using Emu [1], which has been shown to work great for 16S ribosomal RNA analysis on ONT by basically everyone I've heard who tried it. It has a nice algorithm for predicting if variants are due to ONT sequencing errors or are true variants, based on an expectation maximization algorithm, and thus working around the somewhat limited accuracy in ONT reads. Pretty clever stuff.

And if you want to run your own analysis on the raw data using Emu, you might want to try out our Trana pipeline built around Emu in Nextflow [2]. Apart from running Emu, it does some of the preprocessing like filtering, as well as exporting as Krona diagrams etc.

We're just putting it through validation at the clinical microbiology lab at Karolinska here in Stockholm right now.

The main caveat worth mentioning is that the choice of database will affect your results a lot. Might be worth comparing Plasmidsaurus' choice of databasese with the one shipped by default with Emu.

[1] https://github.com/treangenlab/emu

[2] https://github.com/genomic-medicine-sweden/TRANA
by legitster | 2026-01-06 21:58:53+00:00
I keep thinking of Caesar crossing the Rubicon.

Congress has no power, the courts leave it to congress (lol). Every agency has been purged of anyone willing to put up resistance. Checks and balances and the Constitution are essentially meaningless.

To be fair, this is not necessarily new for America. People forget that much of the 1800s was ruled by the spoils system and imperialist, nationalistic presidents. The difference is none of them ruled over the largest standing military in the world or the linchpins of the global economy.
by necovek | 2026-01-06 21:59:07+00:00
Certainly!

But, if a 4-year old boy finds "there's more of them with bigger guns", and a general has a personal interest in hurting someone without you knowing that, you'd be unwise to not consider the words of the boy as you prep your military strategy.

Note that you were careful to establish hard-to-prove circumstances ("served in similar circumstances"), which seems to say that you don't want to discount what the non-expert is saying too easily either.
by theothertimcook | 2026-01-06 21:59:24+00:00
I know I’m not alone in enjoying the rituals and habits around coffee, whether I’m making it, or grabbing a colleague and going for a walk.

Caffeine doesn’t hit the same way nicotine does, but then both are inferior to dexamphet/methylphenidate/modafinil/etc.

I wouldn’t stake my fortune on trying to get something like this off the ground, especially when most convenience stores (barely) sell caffeinated gum.

I would try adding some L-theanine to your caffeine though, 2:1 theanine to caff.

That delivers some of the best bang for buck boost without sucking on pouches or abusing pharmaceuticals, but even then, being non habit forming sometimes I won’t bother rebuying.

Hope I haven’t spoiled anything, best of luck on your product development journey.
by aurumque | 2026-01-06 21:59:51+00:00
In a circuitous way, you can rather successfully have one agent write a specification and another one execute the code changes. Claude code has a planning mode that lets you work with the model to create a robust specification that can then be executed, asking the sort of leading questions for which it already seems to know it could make an incorrect assumption. I say 'agent' but I'm really just talking about separate model contexts, nothing fancy.
by quesera | 2026-01-06 22:00:04+00:00
True, but it required congressional approval to change the name then, and it would now as well.

This congress is not likely to approve it. And the next congress, even less so.

That said, "ever" is probably too strong. There's a window wherein the chaos which is currently being actively created by the US will develop to an extent that compels the US (or is sold to US voters as a necessary step) to adopt a foreign policy where it would be the more appropriate title. And if the adults can't manage that with charismatic leadership in the next election cycle or two, we could be right back here again, with quasi-legitimate geopolitical justification for the sort of big-stick wagging we see today.
by the_af | 2026-01-06 22:00:32+00:00
> Not in itself, but the trafficking of drugs into the US is a US issue.

They are already backtracking on the "Cartel de los Soles" accusation, after finally realizing there's no such organization, but it was always a slang frase about corruption in the military. Source: NYT.

The indictment removed almost all of the mentions of this cartel, now phrasing the accusation in much broader, vague terms.

It wouldn't surprise me if at some stage they changed tack entirely and tried a different angle than drug trafficking, since, let's face it:

It's about oil. Trump is not shy about this.
by headcanon | 2026-01-06 22:01:14+00:00
Yep, I literally built this last night with Opus 4.5 after my wife and I challenged each other to a typing competition. I gave it direction and feedback but it wrote all the actual code. Wasn't a one shot (maybe 3-4 shot) but didn't really have to think about it all that hard.

https://chronick.github.io/typing-arena/

With another more substantial personal project (Eurorack module firmware, almost ready to release), I set up Claude Code to act as a design assistant, where I'd give it feedback on current implementation, and it would go through several rounds of design/review/design/review until I honed it down. It had several good ideas that I wouldn't have thought of otherwise (or at least would have taken me much longer to do).

Really excited to do some other projects after this one is done.
by godelski | 2026-01-06 22:01:38+00:00
In the last 5 years I pretty much fully migrated to my laptop being a terminal for other machines. I more use it like a local machine in HPC: web browsing, word processing, scripting. Anything serious is done remotely. But I also live in the terminal and so realistically what's the difference? 99% of the time the result is that I get to use a "big" computer without having to carry it around.

FWIW, I'm not a big fan of AI coding. I use AI (including LLMs) and I am an AI researcher, but the vibe coding just hasn't clicked despite constant efforts. I guess it can make more sense to do it if you're programming from your phone because while normally typing isn't the bottleneck it definitely is on the phone (or at least far less comfortable)
by toephu2 | 2026-01-06 22:02:10+00:00
"law enforcement could quickly locate and recover the stolen vehicle"

"law enforcement agencies can achieve faster resolutions, greater efficiency, and better outcomes for vehicle theft cases"

Could and would are two very different things in America.

In most cases, the police would simply do nothing.

Facial recognition technology (see Facebook auto-detecting your friends when uploading a photo) has existed for decades. Why do the police still post photos of suspects asking the public in help identifying so-and-so?* Can't they cross-reference with the DMV database or even Facebook to see if there are any matches?

*Although these days they even stopped doing that, I've seen cases where they blurred out the suspects face and then asked the public in help identifying them. They do this to protect the criminal's identity. Sigh. I wish we could bring back name and shame.