MurphyA/hacker-news huggingface dataset:
by petesergeant | 2026-01-29 12:01:38+00:00
Yah. Measuring the effects of these drugs with a single effect size number is ridiculous. They work exceptionally well for some people (myself included). It seems as well that SSRIs work much more reliably on anxiety disorders than on depression.

Getting on them can be a ball ache (or entirely painless; escitalopram was easy on and easy off, Wellbutrin was a nightmare to get on, but also easy off), but entirely worth a shot for anyone symptomatic.
by pseufaux | 2026-01-29 12:01:39+00:00
I read though the GitHub readme but I'm still unsure what "new" this brings this brings to the table. It seems like a thin wrapper over existing tools. Since Microsoft rarely deprecates and removes anything, this feels like just another unnecessary complexity layer.

I'm not a traditional app dev on Windows though, so I'm likely missing something. For those of you who are more familiar, what about this are you excited about?
by Lerc | 2026-01-29 12:01:49+00:00
I don't think 99% of the best is a good metric.

It is highly dependent on what the best represents.

If you had a 100% chance of not breaking your arm on any given day, what kind of value would you place on it over a 99% chance on any given day. I would imagine it to be pretty high.

The top models are not perfect, so they don't really represent 100% of anything on any scale.

If the best you could do is have a 99% chance of not breaking your arm on any given day, then perhaps you might be more stoic about something that is 99% of 99% Which is close enough to 98% that you are 'only' going to double the number of broken arms you get in a year.

I suspect using AI in production will be a calculated more as likelihood of pain than increased widgets per hour. Recovery from disaster can eat any productivity gains easily.
by funkyfiddler369 | 2026-01-29 12:02:16+00:00
If you spend a lot of time among some folks or talk a lot to LLMs, you are guaranteed to pick up manners, manners of speech, ways of thinking, behaviors (where applicable) ...

Me and my brother just can't stop mixing English and German when we talk to each other. But we don't or barely do it when we talk to others.

When I learned about code, logic, math, I started talking and thinking in different ways and from different and towards different perspectives.

The more I read, which I haven't done in a long long while, the more massive and vast the info I pack into a few sentences becomes.

The more I draw or play the guitar or work on game mechanics and story design or dialogues, the more annoying my speech and manners become but to my environment, that also means that I become "more" social and actually somewhat likeable and bearable.

You smell like Non-evidence based arrogance. I was always surrounded by people who smelled like that. But they are good little copypasta soldiers who follow trends and mutually assure that they don't go completely off the rails. But if one does, they leave him on his real or imaginary battlefield. Nobody wants to evolve anymore. It hurts some people just a little too much, I guess. They'd rather poison others and have their code deleted before getting to live a second life. I hope I could get you on edge a little. I'm just fucking around. But you will probably think something the likes of ... "there's always some truth to it when ..."
by infinitezest | 2026-01-29 12:02:38+00:00
> When you let the cat out of the box yourself...

I could say the same thing to you. Go back a few more years to his first term, to his campaign. He is absolutely the main architect of the chaos that has ensued. You don't get to start fights and then get mad when people fight back. The selective outrage you're demonstrating here is baffling.
by onli | 2026-01-29 12:02:53+00:00
2033 is not that far away. If they sell a few thousand items there would still be users, so the kernel would usually not remove the drivers if not defunct.

You might very well be right about the company, it is the likely outcome after all for all companies. But if the kernel support is seeded properly there should be a bit more time than predicted even then.

Also, positively: They did the communication on the website really well (I stumbled over the comet before), extended it nicely and the kickstarter campaign seems to be a big success. They have a good chance to stick around.
by adornKey | 2026-01-29 12:03:00+00:00
Mice can fit through tiny holes. An old rule says that if a pencil can get through - a mouse will get through.
Some mice even fly.
I once had a bat clinging on my good old CAT cable. So even leaving windows open at night might affect bandwidth...

Another classic is the "Frog on Keyboard error". Software developers have to be prepared for everything...

https://thedailywtf.com/articles/Classic-WTF-Cursed-and-ReCu...
by CMay | 2026-01-29 12:04:23+00:00
7 different video angles or 7000 different video angles doesn't really change this. What will matter is the testimony of the people combined with the evidence that exists. They'll have to go over the full timeline of events with radio chatter, officer testimony, testimony of activists, make assessments of who are being the most credible and objective observers, look into these claims about a gun misfiring and so on.

There is no version of this where nobody made mistakes and mistakes don't mean someone should have to die, but laws exist for a reason and you don't know what each person was experiencing simply after watching a video.

Video evidence does not generally have infinite credibility in court, because it is often a limited perspective on the reality of what happened. The cameras can only catch sound waves and photons, but almost the majority of everything important that occurred is invisible. If the audio had much value, all the whistles ruined some of that. It may even turn out that the whistles contributed to this death, because it weakened officer communication. Maybe there could be a justification for involuntary manslaughter by people blowing whistles if they were blowing them precisely with intentions like that. I don't know.

We just don't know and claiming these videos show everything you will ever need to know is simply logically false.
by woadwarrior01 | 2026-01-29 12:04:24+00:00
That's a very tenuous analogy. Microcontrollers are circuits that are designed. LLMs are circuits that learned using vast amounts of data scraped from the internet, and pirated e-books[1][2][3].

[1]: https://finance.yahoo.com/news/nvidia-accused-trying-cut-dea...

[2]: https://arstechnica.com/tech-policy/2025/12/openai-desperate...

[3]: https://www.businessinsider.com/anthropic-cut-pirated-millio...
by compounding_it | 2026-01-29 12:04:50+00:00
As someone who tried citalopram escitalopram and sertraline, along with venlaflaxine and fluvoximine, I would suggest doing a pharmacological test for psychiatric medications.

I am an intermediate metabolized for the first three and the ones I was on most long. It did not suit me and made my orgasms go from ‘wtf’ to ‘that’s it?’ And they are still not normal 2 years after discontinuation.

I am still depressed and anxious to the point of serious consideration of these medicines to save myself, but you can save yourself the experimentation by doing a simple test and avoiding those medicines.

Anxiety depression panic attacks are something I wish more people studied along with sexual health.
by jofzar | 2026-01-29 12:05:20+00:00
> Not just switching to "decaf" (which isn't)

Going to argue here, this is wildly bad advice. Decaf practically has no caffeine, it has 2-7 mg from what I can tell which is less then chocolate. 2-7mg is like impossible to notice and might aswell be water with how little there is.
by luqtas | 2026-01-29 12:05:22+00:00
> I enjoy not drinking feces for example but I'd love to hear your thoughts on how regulation against poopy drinking water is going to be turned against me.

you can't interfere or comment effectively on the policies or processes of your water treatment plant. on the Patreon case the user can simply stop using Apple hardware or move to the web

throwing every problem down to the goverment feels like: i believe in animal rights so instead of going vegan i'll protest to the goverment make it illegal to kill sentient animals for products.

i know we can do both but OP's anarchy solutions feels much more reasonable than expecting the goverment solve stuff. creating a culture that uses de-centralized approaches is times better than sticking to a centralized platform, regulated or not
by shellkr | 2026-01-29 12:05:27+00:00
This made me think of Pauling (https://en.wikipedia.org/wiki/Linus_Pauling) who was a famous scientist and big proponent of high-dosage C-vitamin. He claimed it could cure everything from a cold to heart disease and cancer. Later studies did though not find any benefit of high-dosage C-vitamin and that potentially had a higher risk of prostate cancer. Pauling died of prostate cancer.

Edit: This may also be of interest: https://en.wikipedia.org/wiki/Orthomolecular_psychiatry
by steveBK123 | 2026-01-29 12:05:35+00:00
The Uber comparison is funny because they burned $32B over 14 years before profitability. OpenAI alone is burning something like $10B/year and growing, so the US AI labs are probably close to 10x Ubers burn rate.

Given the scale of AI lab burn rates being so high that the AI Capex shows up in nationwide economic stats, it clearly cannot burn for that long.

So what happens first - labs figure out how to get compute costs down by an order of magnitude, they add enough value to raise prices an order of magnitude (Uber), or some labs begin imploding?

Keep in mind another aspect of the comparison is that there wasn't an entire supply chain spend effect triggered by Uber. That is - you didn't have new car companies building new factories to produce 10x more cars, new roads being built, new gas stations being built, etc the way you have for AI.

It's like the entire economy has taken 1 giant correlated bet here.
by londons_explore | 2026-01-29 12:05:38+00:00
> the exact people who would buy such a car are now avoiding Teslas

The traditional fix for this is to license the technology and do manufacturing for another carmaker to brand.

It's super common for brand X of car to actually be a rebadged Y with slightly different shaped body panels.

However, it only works if your product is good and you have decent margins. That means you have to compete with china cars, since the obvious thing for a western brand to do is to rebadge a chinese designed car and split the margins with the chinese designer/manufacturer.
by neRok | 2026-01-29 12:05:40+00:00
The first link makes the problem sound like it can happen to anyone, but then when you tease out the details;

* Toxicity resulting from lack of monitoring is frequently seen in patients requiring high doses to treat ailments like osteoporosis, renal osteodystrophy, psoriasis, gastric bypass surgery, celiac, or inflammatory bowel disease.

* Patients who are on high doses of Vitamin D and taking inadvertently increased amounts of highly fortified milk are also at increased risk for vitamin D toxicity.

* According to the latest report from America's Poison Centers (APC), there were 11,718 cases of vitamin D exposure recorded in the National Poison Data System. More than half of these cases were in children younger than 5 years.

* The clinical signs and symptoms of vitamin D toxicity manifest from hypercalcemia's effects.

* Clinical management of vitamin D toxicity is mainly supportive and focuses on lowering calcium levels.

* Isotonic saline should be used to correct dehydration and increase renal calcium clearance.

A lot of those point to people drinking too much milk! (enriched milk)

* People with osteoporosis thinking "I better drink more milk for strong bones" when they are already on supplements/medicine.

* Kids drinking lots of milk and presumably not drinking any water - hence the dehydration.

PS: There are a lot of people out there that don't drink any water, and stick to juice or milk or soda, etc. They are not always fat, but that doesn't mean they don't have issues.
Show HN: Zvec – The SQLite of Vector Databases
by zvec | 2026-01-29 12:05:47+00:00
Zvec is a lightweight, SQLite-like embedded vector database purpose-built for edge and on-device workloads. It delivers four core advantages: out-of-the-box usability, configurable resource budgets, extreme performance, and versatile vector capabilities. Open-sourced under the Apache 2.0 license, Zvec aims to provide developers with a one-stop path from prototyping to production deployment on the edge. Try Zvec—we’re excited to see your adoption, feedback, and contributions.

For a more detailed introduction, you can refer to https://zvec.org/en/blog/introduction/
by FridgeSeal | 2026-01-29 12:06:11+00:00
Well the company of the former microcontroller has gone out of their way to make getting and developing on actual hardware as difficult and expensive as possible as possible, and could reasonably accused of doing “suspect financial shenanigans”, and the other company will happily sell me the microcontroller for a reasonable price. And sure, thy started off cloning the former, but their own stuff is getting really quite good these days.

So really, the argument pretty well makes itself in favour of the $0.5 micro controller.
by TuringNYC | 2026-01-29 12:06:29+00:00
>> I wouldn't say thin air, exactly.

Fair but have you seen how long things take in the US? The original proposal for the 2nd ave line was in 1920 and they have only managed to deploy four stops. I read about it in the news when I was in 5th grade and still read about it now, 40yrs later. https://en.wikipedia.org/wiki/Second_Avenue_Subway

Similar for the Hudson tunnel which is supposed to allow commuter trains to function w/o the current madness...
by Deklomalo | 2026-01-29 12:06:45+00:00
I just calculated it for 40 cents per mi and just the basic commute to my company would cost already 40 euros.

But I calculated traveling 2 times a week, of course at the commute time everyone else commutes and public transport costs 50 Euros per month.

My company car though costs 200 Euros + 100 Euros energy.

Im pretty sure cybertaxi can't and will not provide 40 cents / mi in high demand times, for middle class paying more mone for the convinince of having your own car is still cheap and if i need to do anything further away like any trip, it will be expensive again.

And all of these cybertaxis have to live somewere.

The math doesn't make sense already.
by account42 | 2026-01-29 12:06:55+00:00
> We live in a time where innocently surfing the web can result in seeing a single screenshot and completely ruining a game

A game where seeing a single screenshot ruins the experience wasn't very substantial to begin with.

> Because information equals progress in this genre, there’s typically no way to brute force the path forward whenever you find yourself truly stuck.

Except that is almost always possible - games by their very nature are usually very restricted in what you can do which makes exploration of all possible options possible. But usually better would be trying to reason about the problem. Looking up outside help is and has always been equivalent to giving up - which is fine if you don't want to solve the puzzle but definitely not needed to progress if you are patient.
by soulofmischief | 2026-01-29 12:07:29+00:00
1. I never asked to "debate" with you.

2. You decided to leave a comment on one of my comments, except it contained multiple straw man arguments and a gross mischaracterization, arguing in bad faith from the start.

3. I pointed out the issues with your comment, and asked if you had an actual point to make, or if it was just straw man arguments. I had no intention of continuing a discussion with you and do not need to provide you "points to respond to". I agree, when I have to stop and explain why your argument has issues, it derails the thread. That's the problem with straw man arguments.

4. It is your problem if you take issue with criticism and think it means I need to be "helped out" by "someone with more patience". That's quite a condescending response.

I can see that you didn't have a point to make, and instead elected to just take a bunch of negative jabs at me as retaliation for pointing out the errors in your argument.

So yes, let's end the conversation. It's quite ridiculous.
by cbolton | 2026-01-29 12:08:15+00:00
I think you have the right idea, if poorly worded. The economy is not a zero sum game, but the idea works when you apply it not on wealth but on wealth increase. That's more or less the famous r > g formula of Piketty: when the rate of return of capital is larger than the growth rate of the economy, wealth gets more concentrated. The idea has been disputed but the basic principle certainly applies in many situations.
by TuringNYC | 2026-01-29 12:08:47+00:00
>> The Elizabeth Line was unbelievably expensive to build; that's how the UK did it.

Fair. But what is also expensive is every single citizen taking $100 Uber rides to the airport, like in NYC. In NJ, the transit service has become so volatile and sporadic and opaque that people have reduced NJTransit use for Newark airport in favor of simply driving.
by myrmidon | 2026-01-29 12:09:15+00:00
Relevant excerpt from your own wiki guideline:

"Do not rely too much on your own judgment. [...] if you are an expert user of LLMs and you tag 10 pages as being AI-generated, you've probably falsely accused one editor."

Never accuse people of LLM writing based on short comments, your false positive rate is invariably going to be way too high to be acceptable given the very limited material.

It's just not worth it: Even if you correctly accuse 9/10 times, you are being toxic to that false positive case for basically no gain.
by xmcqdpt2 | 2026-01-29 12:09:36+00:00
> And there are reasons to even be really bullish about AI’s long-run profitability — most notably, the sheer scale of value that AI could create. Many higher-ups at AI companies expect AI systems to outcompete humans across virtually all economically valuable tasks. If you truly believe that in your heart of hearts, that means potentially capturing trillions of dollars from labor automation. The resulting revenue growth could dwarf development costs even with thin margins and short model lifespans.

We keep seeing estimates like this repeated by AI companies and such. There is something that really irks me with it though, which is that it assumes companies that are replacing labor with LLMs are willing to pay as much as (or at least a significant fraction of) the labor costs they are replacing.

In practice, I haven't seen that to be true anywhere. If Claude Code (for example) can replace 30% of a developers job, you would expect companies to be willing to pay tens of thousands of dollars per seat for it. Anecdotally at $WORK, we get nickel and dimed on dev tools (better for AI tools somewhat). I don't expect corporate to suddenly accept to pay Anthropic 50k$ per developer even if they can lay off 1/3 of us. Will anyone pay enough to realize the capture of "trillion dollar"?
by abelitoo | 2026-01-29 12:10:00+00:00
Oral has felt very effective for me. I take a daily supplement that has roughly 100% of the recommended daily dose of everything. I split it in half.

For D3, it is 25mcg / 1000 IU / 125%

After splitting in half it's 12.5 mcg / 500 IU / 62.5%.

I take with some fat-containing food to allow ir to absorb which is usually breakfast (yogurt, some nuts, some kind of fruit, oats), and it's a night and day difference in my mood (how easily I can control my temper if already agitated, how easily I brush off annoying stuff, takes the intensity off of my reactions and mood during conversations).

I did a blood test before starting, and if normal is between 30 - 70, I was at 10. Dr prescribed megadose of D2, followed by daily D3, but I skipped on the megadose and went straight to D3 -- makes me wonder if a megadose would build up my stores since D is fat-soluble and make it so I could miss a day and not notice.

All of the above is anecdotal from me, a self-professed cave dweller, but it's been a couple of years now, and I still notice the difference. Also, what I heard from people in Boston is that 90% of them are on a vitamin D supplement. My friend from there laughed at me when I was raving about it, saying "yeah, literally everyone here is on it".
by cyphar | 2026-01-29 12:10:24+00:00
I am aware of that, my (personal) view is that DRM is a social issue caused by modes of behaviour and the existence or non-existence of technical measures cannot fix or avoid that problem.

A lot of the concerns in this thread center on TPMs, but TPMs are really more akin to very limited HSMs that are actually under the user's control (I gave a longer explanation in a sibling comment but TPMs fundamentally trust the data given to them when doing PCR extensions -- the way that consumer hardware is fundamentally built and the way TPMs are deployed is not useful for physical "attacks" by the device owner).

Yes, you can imagine DRM schemes that make use of them but you can also imagine equally bad DRM schemes that do not use them. DRM schemes have been deployed for decades (including "lovely" examples like the Sony rootkit from the 2000s[1], and all of the stuff going on even today with South Korean banks[2]). I think using TPMs (and other security measures) for something useful to users is a good thing -- the same goes for cryptography (which is also used for DRM but I posit most people wouldn't argue that we should eschew all cryptography because of the existence of DRM).

[1]: https://en.wikipedia.org/wiki/Sony_BMG_copy_protection_rootk...
[2]: https://palant.info/2023/01/02/south-koreas-online-security-...
by senko | 2026-01-29 12:10:33+00:00
Responses API is a commodity.

That's why OpenAI tries to push Assistants API, Agents SDK and ChatGPT Apps which are more of a lock in: https://senkorasic.com/articles/openai-product-strategy-2025

Funny thing is, even OpenAI seems to ignore Assistant/Apps API internally. Codex (cli) uses Responses API.
by shoaibmerchant | 2026-01-29 12:13:03+00:00
Creator here.

I can completely understand the skepticism, any startup today releasing something and promising to support will be taken with a grain of salt. I cannot guarantee that Mecha will not run out of business in 7 years. But at the very least we have the confidence to commit to 7 years of support, if we are able to keep the show going.

Why we are confident of extending this support -

1. The SOC from NXP is widely used in automotives and industries. Their support is listed till 2036, https://www.nxp.com/products/nxp-product-information/nxp-pro... which means their downstream will keep seeing updates. In above comment I mentioned that they follow 6 months+LTS release dates. To give an example, IMX6 that were released in 2011 are still actively supported in 2026. You can even buy SOMs and are still deployed in production.

2. The WiFi chip we are using is NXP IW612, again has longevity till 2038, which means it will still see its driver being updated and maintained.

3. Our audio codec is from Analog (MAX98090) again widely used and in production.

4. Most of our usb and power controllers are from TI, which can be expected to be around in the kernel for a long time.

5. None of the parts we've used are not recommended for new design or obsolete or come from unknown vendors. A lot of care has been taken in choosing the right parts?

From my point of view our work in supporting is to ensure we pull changes, run our test suites, see if everything works and repeat. What am I missing? There are no device drivers built that are exclusive to the Comet at this stage. You can review our device trees on our repos.

Also, we have a longer roadmap ahead of us - selling few thousand units in 5 days is no indicator of how things will be in the future. We are betting on this hardware and more hardware that we release later.

You can sit on the fence and keep expecting us to fail, that is your prerogative. But that doesn't automatically imply that we are ill-prepared.

(edit: formatting)