MurphyA/hacker-news huggingface dataset:
by A_D_E_P_T | 2025-11-16 23:35:29+00:00
The report-writer must have been from Goldman Sachs' B-team. It takes five minutes to turn up ample evidence which demonstrates that curing patients can be extremely profitable.

Take, for instance, Harvoni -- a drug introduced in late 2014 which cures Hepatitis C following a single course of treatment. It has done something like $100B in revenue for Gilead Biosciences, and, minimally, earned them $7-10B in profit. (Possibly much more than that.) Its pricing was scandalous, but that's not the issue here; the point is that it was unequivocally one of the most profitable drug launches in history.

Sure, the eradication of Hep C might make it "unsustainable" -- but it's not as though there's a lack of other diseases or maladies to contend with. Take the profits and plant new seeds, buy new technologies, develop new drugs. Besides, the research and development of new drugs has never been a stable business model, and never truly sustainable off one discovery, on account of patent expiry terms, generic competition, etc.
by Dylan16807 | 2025-11-16 23:35:48+00:00
It's "not unsafe" if you take dozens of ever changing and hard to learn precautions and also get lucky that new exploits and your exposed services don't overlap? That's the internet being very unsafe.

> If you want to see unsafe, look at how someone who doesn't understand tech tries to interact with it.

Personal actions (and their safety) are a different category from environments (and their safety).
by FridayoLeary | 2025-11-16 23:35:55+00:00
Several points: firstly i would assume every country has a process for disposing of bad and worn out notes and coins. If not i'm sure someone could work out how to profit from recycling dead pennies in true capitalist fashion. This leads on to my second point which is when the government has time they should get around to issuing a bill removing pennies (and maybe other smaller denominations) from legal tender.

But there is a wider point which i want to discuss. How long will physical cash last? I'm very fuzzy on this but i think in some of the Asian countries it is practically an endangered species. Tax people don't like large denomination notes. And virtually no legal big transactions take place in cash. America must profit massively from the fact that in many other countries dollars are the go to black market currency but that is a very singular advantage.
by summa_tech | 2025-11-16 23:36:36+00:00
The issue with the lengthy deliberative process is that it provides multiple opportunities for motivated, but ultimately damaging to the public, operators to intervene. In this case, I present to you the Americans for Common Cents:

https://en.wikipedia.org/wiki/Americans_for_Common_Cents

They care more to keep the cent than normal Americans, who ultimately pay for its cost of manufacturing, care to get rid of it. So they'll always win a careful, deliberative process; because they'll show up for the cent _every time_ this comes up. And everyone else gets mildly shafted for no reason.
by sodality2 | 2025-11-16 23:36:48+00:00
Sorry but comparing NSO Group's state actor malware to the tens of thousands of Android malware campaigns targeting everyone's bank account is so completely bad-faith. Every single thing you point to on iOS is about 10000x worse on Android; even if you look straight to state actors, Cellebrite can crack almost every android ever, whereas iPhones take at least a few years and the latest models are almost always protected.

That's ignoring the fact that literally zero average consumers are even targeted by these groups, nor do they have any perception of it. The average person is worried about exactly one thing: common consumer malware.
Show HN: Hirelens – AI Resume Analyzer for ESL and Global Job Seekers
by hl_maker | 2025-11-16 23:37:14+00:00
I built Hirelens (https://hirelens.co) after seeing many ESL and international job seekers struggle with resumes that don’t match job descriptions or parse cleanly in ATS systems, even when they have strong experience.

What it does:

Extracts skills/experience from a resume

Compares it to a target job description

Flags unclear or “non-native” phrasing

Suggests clearer rewrites

Identifies ATS parsing issues

Deletes files after processing (no storage)

Tech: Next.js + FastAPI, lightweight CV parsing → embeddings → scoring logic, LLM-based suggestions, no data retention.

I’d love feedback on:

parsing edge cases

rewriting clarity

what features matter most for job seekers or hiring managers

Try it here: https://hirelens.co
by talking_penguin | 2025-11-16 23:37:31+00:00
You're right. Monitoring is critical for this. You need to know exactly what changed and why.

This is actually where streaming + the actual architecture behing this becomes valuable beyond just "letting users watch." In Helix, every agent interaction is persisted with timing data (DurationMs), tool calls, error states, and even user feedback (thumbs up/down). Sessions track the full conversation history bidirectionally, so you can reconstruct exactly what the agent saw and did at each step.
by 6510 | 2025-11-16 23:37:36+00:00
What epic creation, I probably couldn't stomach reading or viewing this material in any other format.

This is the original programming. You might visualize it complete with a bug tracker, version control, patches, feature updates and programming languages. We can only see it when absurd enough but it gets much more absurd than this and the software may run for thousands of years.

I remember reading and seeing videos about training child soldiers. The weak or injured ones were killed as hunting targets and the more they killed the higher their rank. In the final ceremony that completes the training they had to shoot their parents. It was a great honor and they truly enjoyed it.

We have to remember death is nowhere near the worse punishment. It might be the nicest thing on the list.

Perhaps it is even worse if people don't notice they are in a similar program because it has been refined to such extend.

Imagine if you left the house without clothing. Like a default human, like any other species, or if you like, how god put you on this earth.

Or say, who decided you must use language? Not just that, you must say the correct things at the correct time.

If you get the dress code wrong, fail to speak or construct the wrong sentences well conditioned people from all over the world will come to beat you back in line.

We force the little ones to sit on designed to be uncomfortable chairs the whole day, the entire week. They must sit, not move, shut up and listen.

Someone once "rescued" a small child living on a garbage heap. Gave him foster parents and put him in school. The kid escaped, he went back to playing in the garbage. When asked why he said he wanted to play with his friends. With a look on his face as if he was talking to a crazy person. It was obvious he didn't want to sit, shut up and not move.... forever?

Seems to me we have many bug reports to fill and that patches are welcome. Our cult is far from perfect.
by Gibbon1 | 2025-11-16 23:37:44+00:00
People get confused the hyper inflation in Germany was right after the end of WWI when Germany's economy was collapsing. Turns out you can't fix that with monetary policy.

A point. Economists like people to believe that hyper inflation lead to Hitler. When it was austerity policies at the start of the great depression 10 years later that lead to the Nazi's winning in 33. Same austerity policies in the US lead to FDR and the Democrats winning.
by iLemming | 2025-11-16 23:38:41+00:00
> VSCode is familiar in its UX

That's by design. It must have appealing looks and employ every trick from psychology books to get you to try it and keep using it.

You don't have to be a genius to realize that a for-profit corporation with a $3 trillion market cap, spending millions on building a code editor with no direct licensing model; that they are distributing for "free" is not some kind of unseen goodwill; That shit eventually will generate billions in downstream Azure/services revenue. What is it if not a trivial ROI? It is a "loss leader" in traditional business terms, but a strategic necessity for cloud/services dominance.

VSCode is essentially a Trojan horse for the Microsoft developer services ecosystem - a mental prison that is designed to be easy to get in but hard to escape.

In comparison - vim/emacs have not a single profit motive; their network effect works differently; Yes, there's no entity with trillion dollar market cap to keep the pace with vscode, but no deprecation risks, no corporate pivot that ever is a treat to lock-in your data or your workflow or compatibility with older hardware. Vim & Emacs win by not being a loss leader for anything.

Who can ever predict what happens 5–10–20 years from now? Who can guarantee that some evil CEO wouldn't replace Nadella and secretly start implementing changes in the strategy that would change the essence and the meaning of being a programmer? It is already assumed that every dev has to use GitHub and to know VSCode at least on some basic level today. What if tomorrow your employers would be able to analyze your telemetry data to "measure" your performance? What if the use of anything but VSCode as the code editor would simply be banned?
by jorams | 2025-11-16 23:38:58+00:00
> after frustration with Tailscale in environments where it couldn’t properly penetrate NAT/firewall and get a p2p connection, I decided to invest some time into learning something new: Cloudflare Zero Trust + Warp

...which doesn't even try to get a p2p connection. Instead you always get the thing you didn't want. If you're okay with that you could've just ignored how Tailscale connected those devices, that's kind of the point. You've also in the process converted your entire security model to Cloudflare's idea of "Zero Trust" which involves 100% trusting Cloudflare.

The rest of the blog post is fine, but the motivation is honestly baffling.
by amypetrik8 | 2025-11-16 23:39:22+00:00
yes but what is worth more to the sanfranciscon 400000 mostly non-sanfranciscan hu-man deaths, or 1 outrageous death of a beloved san francisco cat

It is of course such an emotional vs rational argument, so extreme, so ridiculous, what can you do but grab a picket sign and say to ban all cars and combustion engines for the sake of poor kit kat. A very easy sell since combustion engines are already viewed as the devil
by yieldcrv | 2025-11-16 23:39:29+00:00
My vote is “don't need MCP” given that

a) I have agents in production for enterprise companies that did what they were supposed to (automate a human process, alter the point of the whole division, lower cost, increase revenue)

b) the whole industry seems to be failing at doing a) to the point they think its all hype

c) the whole industry thinks they need MCP servers and I don’t
by tsimionescu | 2025-11-16 23:39:30+00:00
> God ordered Israel to wipe out entire people groups, even the children, while listing the sins they committed (including burning their children alive). As I try to understand the morality of it, it would make more sense if our behavior is passed down genetically because some groups could be corrupted beyond all repair. In fact, sparing just one kid later led to Haman in Xerxes' Persia nearly killing all Jews because that bloodline passed its hate and habits down.

Wonderful, trying to justify the evil, bloody, genocidal, murderous god of the Old Testament with modern pseudo-science - and coming from a Christian, apparently. The religion of love and peace, of course, not like all of those other barbarians.
by aw1621107 | 2025-11-16 23:39:31+00:00
> Wrong, for any reasonable definition of memory safety, languages like Java and Javascript are memory safe. Java has escape hatches, but the necessity and prevalence of those escape hatches are way, way less than that of Rust.

What definition of memory safety are you using where (supposed) "necessity" and "prevalence" are factors, and at what thresholds for those two factors do languages cross from unsafe to safe or vice versa?

> In Java, there would typically AFAIK rarely ever be even a single usage of escape hatches. For Rust, the collection implementations in the Rust standard library are typically riddled with the unsafe keyword, even for simple collections. Java handles performance by generally relying on JIT.

So you have Rust, which uses unsafe code for performant collections, and Java, which uses unsafe code via its JIT for performant collections. I'm not sure I see a substantial difference here.
by ssl-3 | 2025-11-16 23:40:26+00:00
Discontinuing the penny is obviously an important thing (otherwise, we'd have been done talking about it by now).

It is always best that important government moves are done in public, with processes that are replete with discourse and understanding, instead of with surprises and confusion.

Ideally, the government would had resolved the (present-day, recently-introduced, inevitable, foreseeable) conflict with SNAP benefits and come up with a single-page, large-print summary that uniformly defined how rounding at the checkout counter works in ways that regular people conducting regular transactions would be able to comprehend and follow.

These details certainly all need to be figured out at some point, and sooner would be better than later: We should have started figuring it out years (perhaps even a decade) ago.

Unfortunately, we did not take that path.

Discontinuing the penny could have been a very orderly nothingburger wherein everyone (on all sides of the cash register) knew exactly what to expect, and exactly when to expect it. But but we didn't do it that way.

So instead, we now we have an element of surprise and confusion instead of simplicity.
by slg | 2025-11-16 23:40:57+00:00
>I read that as a cynical view of the motivations of corporations, not humans.

This is really just the mirror image of what I was originally criticizing. Any decision made by a corporation is a decision made by a person. You don't get to ignore the morality of your decisions just because you're collecting a paycheck. If you're a moral person, the decisions you make at work should reflect that.
by nandomrumber | 2025-11-16 23:41:26+00:00
Is this true in many places in the USA?

You have seperate drainage for shower water and effluent?

That’s certainly not the case here in Australia.

Here, typically storm water and household waste water are carried over a common system. Usually if it rains more than 3mm in 24hrs the treatment systems are overwhelmed and untreated waste is sent out to sea. Coastal areas anyways.
by gadsnprch | 2025-11-16 23:41:38+00:00
Thanks for responding. Solving it will involve public discourse. The negative externality will not be forever ignored and frantic, knee-jerk, legislative or judicial solutions are rarely optimal. Everyone, including Anthropic, benefits from starting the culpability discussion now, ideally in a context just like this. Maybe that’s exactly what Anthropic is doing by framing this news as “we stopped some cybercrime” rather than “we were involved in some cybercrime.” But smart people shouldn’t fall for such a blatant shifting of corporate liability onto the public, imo, and that’s why I’m confused. I must be missing something fundamental.
by api | 2025-11-16 23:42:13+00:00
It’s because a bunch of the tech elite backed Trump, therefore anything tech related must now be evil according to people left of center.

If they’d all opposed Trump you’d see MAGA people making up any reason for anything tech to be evil and calling for AI to be outlawed, and lefty puff pieces about how wonderful and liberating AI is.

Reality is now subordinate to political hyper partisanship. If Trump says the sky is blue, the left thinks it must be green. If Trump says it’s green, MAGA people will swear they see green and seeing blue would become “woke.”
by jjmarr | 2025-11-16 23:43:22+00:00
The suggestions on making sustainable cures:

“Solution 1: Address large markets: Hemophilia is a $9-10bn WW market (hemophilia A, B), growing at ~6-7% annually.” “Solution 2: Address disorders with high incidence: Spinal muscular atrophy (SMA) affects the cells (neurons) in the spinal cord, impacting the ability to walk, eat, or breathe.” “Solution 3: Constant innovation and portfolio expansion: There are hundreds of inherited retinal diseases (genetics forms of blindness) … Pace of innovation will also play a role as future programs can offset the declining revenue trajectory of prior assets.”

It's easy to handwave "capitalism makes curing patients unsustainable" but here we have three strategies for sustainable cures that have a positive impact on society.

e.g. Curing blind children is profitable, since there's so many genetic reasons a child would be blind that you can keep introducing new cures reapplying the same technology.
by throwaway314155 | 2025-11-16 23:43:45+00:00
1.) Awareness doesn’t mean they will use it. And in practice they often don’t use them.

2.) “ unlike cli tools or APIs you don't have to constantly remind it what MCPs it has available” - this doesn’t match my experience. In fact, bash commands are substantially more discoverable.

3.) Again, this doesn’t match my experience and the major providers recommend including available MCP tools in system prompts/CLAUDE.md/whatever.

4.) Can’t speak to this as it’s not part of my workflow for the previous reasons.

The only useful MCP for me is Playwright for front end work.
by weitendorf | 2025-11-16 23:44:35+00:00
Average person stops at this step because you generally need to use at least 2-3 services with separate accounts, logins, guides, and documentation (registrar, DNS/CDN, hosting, GitHub, various other dev tools) and to be prepared to spend some time reading technical documentation and guides, getting it all working together, just to have a website on the Internet that says something you made it say.

Once you start getting into analytics and development and payments and seo and hosts that aren’t just static sites, it’s just too much. There are some companies that try to hide it all behind products positioned towards non-technical website creators but really very few that do a good job at taking you from nothing to a full site. We’re about 2 weeks away from becoming one of those because I think it really isn’t as simple as saying “make your own site” now, even though it could be.
by ekjhgkejhgk | 2025-11-16 23:44:54+00:00
This is so exciting.

Julia's multiple dispatch is really powerful. In my opinion it's great user experience for implementing generic code.

It has a downside: since you don't know at build-time what types you'll shove inside your functions, you don't know what to compile.

But some times the user does know. What does this, according to my understanding, is that if you tell the compiler what types you'll be using it can compile everything ahead of time.
by the_mitsuhiko | 2025-11-16 23:44:54+00:00
> * Contrary to APIs, they can change their interface whenever they want and with little consequences.

I already made this argument before, but that's not entirely right. I understand that this is how everybody is doing it right now, but that in itself cause issues for more advanced harnesses. I have one that exposes MCP tools as function calls in code, and it encourages the agent to materialize composed MCP calls into scripts on the file system.

If the MCP server decides to change the tools, those scripts break. That is is also similar issue for stuff like Vercel is advocating for [1].

[1]: https://vercel.com/blog/generate-static-ai-sdk-tools-from-mc...
by RunningDroid | 2025-11-16 23:44:58+00:00
You can use xcancel.com or farside.link's nitter redirect to avoid that, if you're on Android it's easiest to use URLcheck‡ with these chunks added to the pattern checker:

``` "Twitter to Nitter": { "regex": "^https?:\\\/\\\/(www\\.|mobile\\.)?(twitter|x)\\.com\\\/(.)", "replacement": "https:\/\/farside.link\/nitter\/$3", "enabled": "true" }, "Twitter image to Nitter": { "regex": "^https?:\\\/\\\/(pic\\.twitter|pbs\\.twimg)\\.com\\\/(.)", "replacement": "https:\/\/farside.link\/nitter\/pic\/$1", "enabled": "true" }, ``` (I haven't updated my copy of the Twitter image regex for the rename because I haven't seen any X.com image links and upstream seems dead)

‡: https://github.com/TrianguloY/URLCheck
by antasvara | 2025-11-16 23:45:13+00:00
This could be anything, so making a sweeping generalization is premature IMO.

It could be insider knowledge that Intel/AMD/other has made a huge step forward and has reduced Nvidia's moat (unlikely considering his public support for Nvidia's hardware, but possible).

It could be that the AI bubble is popping.

It could be that he wants to "lock in" the gains that Nvidia has made; having that much capital in one company tied to a pretty volatile sector is risky.

Maybe he thinks that the beneficiaries of AI will be B2B companies like Microsoft with connections to most major businesses.

Maybe it's a changing view on how much compute will be needed to fuel AI developments moving forward.

And this is just the list I could thing of off the top of my head. There are plenty of other reasons this move could be happening. Absent an inside line on Thiel, anything else is speculation.
by talking_penguin | 2025-11-16 23:45:35+00:00
Ha, we'll take it! It's definitely ambitious - we're essentially building a full remote desktop streaming stack on top of an AI stack on private data.

The 'madness' part is probably the part where we said 'let's do hardware-accelerated H.264 encoding and real-time agent control and make it all work with sub-100ms latency.' We think the problem space is worth the complexity.
by themafia | 2025-11-16 23:45:35+00:00
> Just say it and stop wasting everyone’s time.

I didn't waste your time. I posed a question. Your options were to ignore it, answer it, or complain about it. You've decided to complain and thus have maximally wasted your own time.

The point was, perhaps instead of saying things that are absurd, one should look at the graphed data to draw conclusions. I didn't /want/ you to guess, I wanted you to just go look. Or probably just admit to what you almost certainly could have guessed or already know is true.
by 5555624 | 2025-11-16 23:45:53+00:00
Per the U.S. Mint, the life span of a coin is 30 years:

"A coin’s typical lifespan is 30 years. See https://www.gao.gov/assets/gao-19-300.pdf, page 6."

For paper money, depending on denomination, 5.7 to 24 years. (https://www.federalreserve.gov/faqs/how-long-is-the-life-spa...)
by CuriouslyC | 2025-11-16 23:45:54+00:00
To add to this, agents view the world through sort of a "choose your own adventure" lens. You want your help output to basically "prompt" the agent, and provide it a curated set of options for next steps (ideally between 4-8 choices). If your CLI has more options than that, you want to break as much as possible into commands. The goal is to create an "decision tree" for the agent to follow based on CLI output.
by vel0city | 2025-11-16 23:45:55+00:00
I think a lot of people would consider having a rack at a colo to be "on-prem". I usually thought of that term meaning you're renting space and the services provided are redundant/reliable power, a public internet drop (or multiple), and physical security. Where you need to rack it yourself, run your own networking gear, etc.

I don't see how that's too functionally different from having a suite at a commercial office building, save for the fact the power and data isn't going to be nearly as reliable. It's just your "suite" is only a bit more than 19" wide.
by refurb | 2025-11-16 23:46:43+00:00
I had the same impression - this article demonstrates the depth of knowledge I’d expect from someone completely unfamiliar with the industry.

Most people in the industry could name several examples of cures that are highly profitable.

Not to mention patented drugs are inherently an “unsustainable business” due to the eventual introduction of generics/biosimilars.

Depending on your development pathway, you’d be lucky to get 6-8 years to turn a profit.