MurphyA/hacker-news huggingface dataset:
by cthalupa | 2025-11-09 07:45:31+00:00
The National Lipid Association and American Heart Association have both been advocating that lower cholesterol numbers are better, e.g. https://www.lipidjournal.com/article/S1933-2874(25)00317-4/f...

Research science in this area has been in agreement for a long time now that ApoB is a more informative indicator than just LDL-C, because there are a variety of different atherogenic particles, not all LDL particles are created the same, etc.

His ApoB numbers are quite readily and apparently out of range. Hell, even his LDL is out of range for the two largest lab providers in the US - Labcorp and Quest both have <100 for their reference range. But the science shows that plaque progression is still generally occurring at levels above 70 LDL-C even with low Lp(a) and other atherogenic particles - the reference ranges are likely to get moved lower and lower as practice catches up with research.

His numbers are well within the range of concern based on pretty universal consensus across the research in this area over the past couple of decades. Preventative cardiologists and lipidologists would almost certainly agree with this concierge doctor.
by netsharc | 2025-11-09 07:46:48+00:00
Man, looking forward to the paying experience also being enshittified.

Actually with my card in Europe it's already happened: any payment purpotedly being done overseas (even if it's in the local currency) has some % surcharge. One time some pop-up store came to my town, and they brought a card machine from their store in France. Charged in my local currency, and my bank charged me more. Luckily I could call them with much annoyance and get it credited back.

From online chatter I've heard that paying for Netflix or some other foreign service induces this charge too.
by JumpCrisscross | 2025-11-09 07:48:17+00:00
> Be specific. Which article and which citation? Otherwise this is insinuation or even slander

I’m literally calling out a liar. Not sure how you missed that.

But sure. This is the article [1]. Excerpt from my e-mail to the author:

“I came across your post through Dealbook today. In your article you mention that it is ‘argued that [Sarbanes-Oxley] would hurt initial public offerings, which it didn’t.’ You link through to a working paper on the SSRN at ‘didn't’. From the paper linked to:

‘Although the 2002 Sarbanes-Oxley Act and the 2003 Global Settlement have reduced the attractiveness of being public for small companies, we argue that the more fundamental problem is the increased inability of small companies to become and remain profitable.’

The paper, in whole, posits that structural changes in the attractiveness of exit by acquisition versus IPO are the salient factor behind a secular decrease in IPO activity…Furthermore, the paper directly concedes (see quote above) that SOX negatively impacted IPO activity. This is not how you represented it in your article.”

Eisinger’s response: “Thanks, [JumpCrisscross], for your thoughts.”

> what you've done here is defame every member of the ProPublica staff, past and present (because you don't name a particular writer or article)

I’m calling Jesse Eisinger unreliable. Since he’s a founder in good standing at Pro Publica, I’m calling out the publication. Honest journalists don’t get free passes for negligent or crooked bosses.

Pro Publica is worth reading. It is not authoritative—it does not hold itself up to journalistic standards, a rot which starts at the top.

(I’ve used the above exchange to block Pro Publica from influencing lawmaking on Cheyenne, Albany, Sacramento and D.C. I would want anything they say independently corroborated before being acted on.)

[1] https://www.propublica.org/article/the-sox-win-how-financial...
by kalleboo | 2025-11-09 07:49:47+00:00
> Under terms being discussed, Visa and Mastercard would lower credit-card interchange fees, which are often between 2% and 2.5%, by an average of around a tenth of a percentage point over several years, the people said

Meanwhile interchange fees in places like EU and Australia are more like 0.3%

The Visa/Mastercard duopoly really needs to be broken up somehow.

I live in Asia where there is a cambrian explosion of QR-code based payment methods. At many shops you'll see a list of accepted payment methods like this[0], indicating a healthy amount of competition in payments.

[0] https://corporate.fithouse.co.jp/wp/wp-content/uploads/2021/...
by gadiyar | 2025-11-09 07:50:00+00:00
TIer here. I used to work on OMAP USB back in the day, including on the OMAP3 and this particular board. Mainly Linux drivers, so not directly on the boot behavior which was done by ROM code. Fond memories and nice to see this pop up today. I’m generally curious if Doug ever asked about the behavior on the linux-usb mailing list or elsewhere and what the response was. There were a few of us from that time that might have been able to help.
by winternewt | 2025-11-09 07:50:00+00:00
I see where you're coming from. But I often find that when I have some idea or challenge that I want to solve, I get bogged down in details (like how do I build that project)... before I even know if the idea I _wanted_ to solve is feasible.

It's not that I don't care about learning how to build Rust or think that it's too big of a challenge. It's just not the thing I was excited about right now, and it's not obvious ahead of time how sidetracked it will get me. I find that having an LLM just figure it out helps me to not lose momentum.
by Brajeshwar | 2025-11-09 07:50:45+00:00
Quite a while back (I think 10+ years), I began to realize that I was too dependent on Phones for even the basic info. So, I’ve gotten back to writing a lot more and use Notebook + pen. It helps. I still use Phones but I like the idea of being able to know numbers, and details without pulling out the phone for everything.

Using the dialpad instead of the Saved/Favorite Name in the phones is an interesting habit I built up even for most used numbers such as my wife, sister, and even the neighbors. I remember quite a few numbers; even if I cannot say it, I can look at a keypad and the muscle memory kicks in.

This is the same for some key Passwords, I quite often just type them out. Again, I might not remember but my fingers just glides through the keyboard. I remember it being handy at a hospital making some large payment saving my brother’s family from malaria in a Hospital in Bombay.

Btw, it is also fun to no look at Map on the phone for most journey that I already have an idea or traveling for the 2nd time and henceforth.
by Someone | 2025-11-09 07:52:16+00:00
The article doesn’t mention performance. Because Forth programs basically chain subroutine calls together, it’s a safe bet it is bad on modern hardware with its multitude of caches.

That’s something you could prevent with an advanced compiler that inlines lots of code and carefully tries to put functions often called together in cache lines, but this code doesn’t do that, and if you did, why spend that effort on your compiler if a simple traditional language makes that inlining easier?
by invaliduser | 2025-11-09 07:52:21+00:00
Most people have no sense of security. They say yes to strangers if asked to plug in a USB device on their laptop. When I said no in the train to someone asking to plug their device "for charging", I was definitely the bad guy.

Just find anything plausible, for backup storage, or say, to share family photos with grand parents but it does not work on my home wifi because my ISP is blocking ports, whatever.
by LexiMax | 2025-11-09 07:53:14+00:00
> So your position is that opinions (from all parts of the political spectrum, depending on topic) get routinely supressed via the flagging system, making HN a "non-functional social space"?

Pretty much. Hacker News is half sockpuppets/throwaways, and half internet handles who smile in your face while holding a knife behind their back, ready to stab you in the darkness.

That's not an environment suitable for conducive connections with other human beings, though it's a mighty fine way to drive engagement by turning any slightly controversial thread into a voting/flagging war zone.

You want my advice, find communities with real people in them, places where people are more than an internet handle. Find communities with accountable moderation. Get to know people, learn about their life outside of whatever the topic of the day is. Heck, even meet them IRL. Touch grass.
by krasin | 2025-11-09 07:53:31+00:00
In the meantime, China is constructing nuclear cargo ships ([1], [2]) that will be able to transport 14,000 containers at full throttle (200MW) without a need to refuel for years.

Obviously, it's still not done, and yet to prove to be profitable, but their reactor design does suggest that they have a chance to make it work and replace a lot of CO2 emissions.

1. Original article, but paywall: https://www.scmp.com/news/china/science/article/3331031/chin...

2. Derivative (+based commentary), but no paywall: https://www.chosun.com/english/world-en/2025/11/07/MND3QUGUT...
by bsder | 2025-11-09 07:54:03+00:00
The plural of anecdote is not data.

Maybe he got missed--let's concede that. What about the other 10 or 100 or 1000 or subjected themselves to tests and didn't find anything? Where are their stories?

If you have enough people, the tests, themselves are eventually going to harm somebody.

For example, certain scans require contrasts like gadolinium that bioaccumulates. That's not a big deal if we only pump it into people 2 or 3 times in their lives when something in their body is about to explode. It's a lot bigger deal if we're doing that to them every year.
by mekoka | 2025-11-09 07:54:14+00:00
I see a few of my words and others that I neither said nor thought. With respect, perhaps you're rushing in a particular unrelated tangent and drawing conclusions.

The points I was trying to draw your attention to was that duck-typing as it's done in Go (structural typing to be more exact), is at the crux of its approach to interfaces. Do you understand duck typing or structural typing?

To summarize what I've already tried to say before, Go interfaces are not Java interfaces. Java cares about the interface as a type, while Go cares only about the listed methods (the behavior). These are two completely different paradigms, they don't mix so well, as former Java programmers doing Go are discovering. In Java, interfaces themselves are important because they're treated as types and programmers tend to be economical about them. They're used everywhere to say that a class implements them and that they're a dependency of some consumer. In Go the interface is just a convenient but unimportant label that points to a list of methods that a consumer expects a particular dependency to have. Only the list of methods is meaningful. The label isn't. That's it. Done.

Again, completely different paradigms. If you embrace Go interfaces, the way you read, write and think about Go code also changes. But complaining about them with a Java mindset is complaining that a wrench is a bad screwdriver.

At the end of the day, it's up to you to decide whether you can open your mind and actually learn to use a tool as it was meant, or just assume that its creator and all the people that claim to do so successfully are in denial for not admitting to share the pains you have.
by rixed | 2025-11-09 07:54:32+00:00
Sigils are just one of the things that concern me (use of UTF-8 character for keywords is another one).

The problem with sigils is that they compose poorly when casting (refs, counts), and do not generalize to other types.

Plus, they seem to encourage the language designers to implement semantic that is "context aware" which would have been another billion dollars mistake if perl had become more popular.

In other words, that's unnecessary complexity bringing the attention to a poor type system. A bad idea that deserves to die, in my opinion.
by Tadpole9181 | 2025-11-09 07:54:59+00:00
The DHS and ICE just randomly changed rules to this articles "expedited" process, officially declared that no paper documents count - only their homebrew app, and are now engaging mass raids without evidence or warrants that cause damage to people and their property with no means of reconciliation; this includes targeting home-born American citizens.

This article is explicitly reactive and says so itself! None of these documents mean just about anything anymore - yesterday it was A, today it is B, tomorrow it is C. The rule of law has broken down in America.

We've seen an entire national campaign about a man deported to a prison in a country he was being protected from. The administration has been caught with numerous citizens now. While arguing they have no requirement of due process and have a right to deport anyone anywhere they please.

There's not negative value, you should still do it and hope there's still someone to stop them somewhere in the process. But believing this is simply a matter of "getting your papers in order" or explaining how "this is a bad idea" to them is nuts... as if the Nazis ever cared about the papers. If a Nazi official wanted you gone, you were gone. That's how fascism works.

And before I hear anyone say "oh, please, Nazis, don't be irrational", Greg Bovino is effectively the commander-at-large of CBP. Today he did a Nazi salute in front of a crowd of people.

And that's what America is, just 10 months in. An authoritarian police state with a Gestapo that's rapidly escalating. With no one left to stop them, it seems, what with local LEO and the NG and SCOTUS and Congress all being in on the game.
by cthalupa | 2025-11-09 07:55:01+00:00
Every organ in your body that utilizes LDL can synthesize it de novo. Some of the heaviest users, like your brain, literally can't get it from your serum LDL levels - they do not pass the blood brain barrier. It is all synthesized locally.

PKCS9 inhibitors and mendelian randomization studies show that people function just fine with <10 LDL-C. (Other comments I have made in here have links to all the relevant studies)

Googling for statin and aggression links I find a fairly small set of studies with fairly disparate outcomes.
by gsf_emergency_4 | 2025-11-09 07:56:27+00:00
OP needs to drop CO2 DAC* and focus on scaling radiative cooling (this is probably the most effective research that the West can undertake)

https://youtu.be/dWJi8pRBW4E

*not to say that getting China to require (PASSIVE) CO2 filters on their ULCVs IS the optimal path forward-- but that tech already exists

The following is just bad marketing https://www.wartsila.com/marine/products/exhaust-treatment/c...
by autoexec | 2025-11-09 07:57:04+00:00
> Those 4.5 million survey responses were gathered over a decade

I'd feel more confident about the results of this research if it didn't entirely depend on self-reported data from a survey. At least in this case it was a phone survey and not just an internet questionnaire posted to social media sites. I'd put more faith in a much smaller sample of young people being professionally evaluated for memory problems.

The survey asks the question: "Because of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions?"

It doesn't ask what physical/mental/emotional condition they have, or even if they were diagnosed with it by a professional (although it does at one point ask if a doctor has told them they have a depressive disorder).

Some years the survey included optional questions (which people may or may not have been asked) that asked if they were taking medicine or receiving treatment from a doctor or other health professional for any type of mental health condition or emotional problem, but again, didn't ask what that condition was.

If you told me that there has been a surge in young people over the last ~10 years who self-identify as having a mental or emotional problem that they themselves suspect has caused difficulty concentrating, remembering, or making decisions I wouldn't be at all surprised.

I'd be more curious to know if there were a surging number of young people who were being diagnosed and treated for serious memory disorders recently.
by jackjeff | 2025-11-09 07:57:44+00:00
The UK has no problem asking their ISPs to block the Pirate Bay. Why can’t OFCOM do this? I don’t understand the attempt to pursue this in a foreign country. It’s fairly obvious that what they’re doing are not considered crimes in the US and politically it looks bad from Trump and his administration. And also, until 5 mins ago I had no idea this site existed. Now I do. Seems to achieve the polar opposite as I’m in the UK and browsing a dangerous forbidden site now. Wooooo
by apparent | 2025-11-09 07:58:09+00:00
I recently participated in a research study, and at one point, the researcher told me I was going to be given 3 minutes with a list of 20 words. I was to memorize as many of the words as possible. I would then be asked to perform a specific task, and then repeat back as many of the words as I could.

When I was given these instructions, I realized it's been many years since I had to memorize anything of meaningful length. I spent the first 20 seconds trying to remember as much as I could about how to memorize things, and the rest of the time actually memorizing. It truly is a muscle, and I was very out of practice.
by martin82 | 2025-11-09 07:58:40+00:00
"adults use smartphones"

Is this so?

I think of it like the time when Hong Kong was flooded with Opium.

"adults smoke opium"

If you find that too crass, there are countless other ways to put it:

"adults eat sugar"

"adults watch TV"

Just because everyone in the mainstream does something, DOES NOT mean that this is a good thing or a smart thing to do.

In fact, we can easily observe that the few adults who are at the absolute top of their game, the most skilled, the most wealthy, the most powerful... well guess what? They DO NOT use smartphones. They don't tweet. They don't have profiles anywhere.

Except for GPS directions, there is actually very very little actual need to use a smartphone. At work, you have a computer for access to Google. At home, you have a tablet or TV or books or a Kindle for media consumption.

You can just swipe a credit card for payments.

A smartphone is not at all needed to be a highly functioning adult.

In fact - it actually prevents you from ever unlocking your fullest potential by removing any chance for your brain to ever catch a breath and just be bored for half an hour and hear your own thoughts.
by wjnc | 2025-11-09 07:59:57+00:00
Profound point. My mother struggled with alcoholism and ultimately succumbed to that disease. In philosophy of mind they use “akrasia” and “akratic thinking” for acting against ones better judgement. It helped me somewhat getting to understand what my mother was going through at that time.

She wanted to change, tried a many multiple of times and it failed. Fault, guilt, blame are useless concepts to use on the Other. And only in moderation should they be applied to the Self. There deep disconnects between what we think, know and do.
by adalacelove | 2025-11-09 08:00:05+00:00
Everybody chooses a favorite depending on their domain.

A function executes, and some error happens:

- Return error value: try to handle the error ASAP. The closer to the error the more detailed the information. Higher probability of recovery. Explicit error code handling throughout the code. Example: maybe you try again in one millisecond because the error is a very low probability but possible event.

- Exception: managing errors requires a high-level overview of the program state. Example: no space left on device, inform the user. You gather the detailed information where the error happened. The information is passed as-is or augmented with more information as it bubbles up the stack until someone decides to take action. Pros: separate error handling and happy path code, cleaner code. Cons: separate error handling and happy path code, unhandled errors.

Worst case scenario: you program in C. You don't have exceptions. You are forbidden to use setjmp because rules. A lot of errors are exposed directly to the programmer because this is a low-level language. You return error codes. Rules force you to handle every possible return code. Your code gets incorporated as an appendix to the Necronomicon.
by cthalupa | 2025-11-09 08:00:36+00:00
You really should push for an ApoB test in general - most people are bit by LDL-C and not other atherogenic particles like Lp(a), but it's still common enough to find out. The good news is Lp(a) is largely genetic so if you know you have low levels you likely don't need to test again anytime soon.

A CAC will show calcified build-up, not reversible (or at least not in any appreciable way)

A CTA will show soft plaque buildup, which IS reversible with a low enough atherogenic particle load. This generally means keeping your LDL-C below the 50-70 range, though if Lp(a) is the cause you'll likely need a PKCS9 inhibitor or an upcoming CETP inhibitor to drive it down.
by pogue | 2025-11-09 08:03:23+00:00
This was the model YikYak used and it was so much fun. They very much promoted it for use at colleges for students, but ended up geofence blocking it around high schools/middle schools because of cyberbulling concerns.

But, if enough people used it around certain areas, it could be a lot of fun & very helpful just to chit chat & talk about the weather & etc.

https://en.wikipedia.org/wiki/Yik_Yak

EDIT I can't accept the terms on my Samsung phone, as the text is over top of the buttons and I can't do anything but scroll the terms. Not sure if this is a browser (Brave) problem or a font size or what.

https://imgur.com/a/LjFFLn5
by AnthonyMouse | 2025-11-09 08:03:40+00:00
There are two major classes of pirates.

The first is people who don't have the money, e.g. students. They will never pay you; they don't have the money.

The second is people who do have the money but value the experience above other things. These would be your best customers, if you provide the better experience.

If you don't provide the better experience, they don't pay. Is that a rationalization? Maybe, but are you better off to whinge about it or to take away their excuse?
by insin | 2025-11-09 08:05:48+00:00
JSX was such a breath of fresh air after having written and maintained apps which used both of these formats for years (and also having written a library which supported both of them for reusing the same templates on the server and in the browser) - it's the commas! I'm glad it's everywhere now.

But that was also back in the days when trailing commas at the end could break things, JavaScript editor support was relatively poor, and tooling wasn't where it is now (knowing your code is once again valid because the autoformatter just kicked in).
by sim7c00 | 2025-11-09 08:06:24+00:00
it is used here n there but unlike bullets the attacks if they remain unknown have no armer to defend against them, but are single use.

since the 2010s atleast more than 140 countries spend over 10 mil a year on purly offensive cyber. most of those countries spend astronomical amounts more than that. that includes purchase of attack tools and exploits
by martin82 | 2025-11-09 08:07:45+00:00
There is no reason take statins, ever. They will destroy your muscles, then cause diabetes and thus indirectly kill you. They will prevent a heart attack by... four days.

If biomarkers are elevated, the question must always be, "why is this elevated", and "is there a natural change in habit and diet that can reverse this elevation".

Artifically lowering the marker with a drug is like pasting duct tape on a leaking pipe - the leak is still there and it will likely quietly get worse over time and then eventually kill you anyways.

I find it unbelievable that our society swallows any drug without second thought. You body produces cholesterol on purpose. There must be reason why it produces it. "Ah well, who cares, let's just throw in a wrench and make it stop producing the cholesterol" and hope for the best...