MurphyA/hacker-news huggingface dataset:
by cthalupa | 2025-10-01 21:25:51+00:00
Trig/HDL and LDL/HDL ratios are outdated science that have been superseded by our better understanding of the causative factors and our ability to drive LDL way lower than we could in the past.

MR studies have shown very little evidence higher HDL does much, if anything, to prevent CVD or serious adverse events.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

CETP inhibitors keep getting abandoned because they're not seeing improvement in cardiovascular outcomes, despite significant increases in HDL. One of the few that did show improvements in outcomes, anacetrapib, appears to have done it through a more significant reduction in LDL than the others, but even then, it was not promising enough for Merck to continue development, and it has since been abandoned.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5756107

The current CETP inhibitors still in development such as obicetrapib are focused primarily on their ability to lower LDL rather than raise HDL.

MVMR studies are also quite clear that absolute atherogenic particle count - primarily LDL-C/Lp(a) - are far more important than HDL #s. ApoB, which calculates the total of your atherogenic particles is probably the best marker we have.

https://journals.plos.org/plosmedicine/article%3Fid%3D10.137...

For a while we thought looking at sdLDL in particular might be a more specific signal to look at, since these are more atherogenic than larger LDL particles, but we've found they correlate so strongly in the vast majority of cases that it's really only something that matters as an exception rather than the rule
by somethoughts | 2025-10-01 21:26:14+00:00
I feel like it'd be perfect if all these school replacements (home-school, charter school, online only schools) went after replacing the dearth of quality after school options.

Really the only options for after school activities after graduating from elementary school are competitive sports, competitive math, competitive music, competitive chess, etc. which are pretty much all zero sum in nature.

I'd love options for kids that let them gradually explore their interests to help them discover future vocational interests in a way that was beneficial to society such that they don't have an existential crisis when they hit senior year in high school and have to pick a college major.
by ryandrake | 2025-10-01 21:26:15+00:00
Everywhere I've worked, come annual review time, everyone is supposed to emphasize what they did, not what the team did. "We're considering promoting you, not the team, so tell us what you did!" Same with interviews: You're not supposed to say "I was a key contributor of Team X that shipped Product Y." You're supposed to say "I shipped Product Y."

So you have this weird contradiction where you're expected to work as part of a team, but then measured on your own contributions in a vacuum. So if you take credit for the team's effort, you're the bad guy who gets rewarded, but if you admit it was a team effort and take credit only for your contributions, you're forgotten for not having enough impact.
by ElevenLathe | 2025-10-01 21:26:20+00:00
> Electricity is fundamentally priced on the margin and if you start forcing nuclear costs on the ratepayers they will build rooftop solar and storage like crazy, leaving you without any takers for the nuclear based electricity.

The regime can just make it illegal to do rooftop solar or home batteries. In a functioning country this is easy enough to push through as a safety measure (lithium battery fires are legit scary, at least in videos). In the U.S. you can just start a campaign to get people fired for endangering their neighbors with dangerous woke energy, no legislation needed at all.
by MatteoFrigo | 2025-10-01 21:27:30+00:00
I don't dispute your general sentiment that the ZK terminology is abused. However, at least one serious attempt exists to deploy a real ZKP system.

Specifically, our system [1] is available as open source [2] and work is underway to implement it in the EU age verification app [3]. I understand that this thread is about the UK and not the EU, and I make no claims about the UK. The system is not theory, but it is already shipping in Google Wallet [4] and in the Open Wallet Foundation multipaz system [5].

[1] https://eprint.iacr.org/2024/2010

[2] https://github.com/google/longfellow-zk

[3] https://ageverification.dev/av-doc-technical-specification/d...

[4] https://blog.google/products/google-pay/google-wallet-age-id...

[5] https://github.com/openwallet-foundation/multipaz
by input_sh | 2025-10-01 21:28:23+00:00
I mean not the whole Europe and this is obviously geography-dependent, but those "dark periods" are fairly common for Germany, as in there are weeks-long periods where Germany itself produces basically no electricity from wind or solar. In the most extreme case some years back, that "dark period" lasted almost two months.

This isn't to say they can't import it from elsewhere, they just can't make any of their own. Adding more capacity wouldn't do anything, it would take an incredible amount of batteries to handle the more extreme end of those "dark periods".
by pfdietz | 2025-10-01 21:28:44+00:00
That report is from 2020. Costs have fallen greatly since then, particularly for battery storage. And even so, that report doesn't say fossil fuels are needed (although the "net zero" solution still is allowed to burn some, I'm guessing because CO2 absorbed into the oceans isn't being counted?) It even says explicitly that hydrogen would be used for long term storage! See pages 5 and 6.

With hydrogen available renewables can straightforwardly get to 100%. Germany has plenty of geology for hydrogen storage. As I mentioned elsewhere, long term thermal storage is also a possibility, with recent developments there suggesting very competitive capex.
by ndelage | 2025-10-01 21:28:57+00:00
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by shawneechase | 2025-10-01 21:28:57+00:00
Most AI “agents” are just slightly smarter chatbots. They suggest, they recommend, but they don’t actually do.

A student team (Chex) just won a hackathon by showing what happens when you split responsibilities across three specialized agents with the right tools:

1. Check-in agent – monitors calendars/notes, spots stress, reaches out via voice.

2. Resource finder – scrapes + searches to assemble therapist options.

3. Scheduling agent – calls offices, negotiates times, books appointments, sends confirmations.

During the live demo, the system actually called a therapist, scheduled a Monday 11 AM appointment, and dropped invites into calendars. That’s a very different experience from “AI suggests you should maybe call someone.”

Why it worked:

- Separation of concerns → each agent has a tight job and only the tools it needs.

- Least privilege auth → the scheduler doesn’t touch your Notion notes.

- Async handoffs → research continues while you do other things.

- Specialized interfaces → voice for empathy, text for lists, background for scheduling.

This “3-agent pattern” is bigger than mental health. Same flow works for:

- Sales (monitor CRM → research prospects → book meetings)

- DevOps (monitor logs → diagnose issues → deploy fixes)

- Recruiting (scan applicants → research candidates → schedule interviews)

Curious: for those experimenting with multi-agent systems, how are you structuring responsibilities and handoffs?
by humanfromearth9 | 2025-10-01 21:29:19+00:00
This may have multiple causes (past experience/trauma, energy levels, existing depression, sleep troubles, anything on the spectrum of autism, like ADHD...).

As far as energy levels go, if you are already tired, you may lack energy to cope with stressful situations, which leads you to procrastinate or even sleep too just not face it. From personal experience, low (just below the lower limit, so nothing seemingly dramatic) vitamin D levels may affect one's energy levels negatively (always tired, brain fog, everything feels hard...), and having appropriate vitamin D levels may already provide one with a clear mind and remove the hardship of dealing with most of what others consider as seemingly simple situations.

You might be depressed because of low energy levels, instead of the other way around.

So, make sure your energy levels are appropriate and that your mitochondria work fine. (Any LLM will provide you with detailed info about energy levels and mitochondria).

Of course, that's only based on personal experience, and I'm a software engineer, not a Doctor.

Have a nice day.
by posix86 | 2025-10-01 21:29:29+00:00
Cursor does this for me already all the time though, give that another shot maybe. For refactoring tasks in particular; it uses regex to find interesting locations , and the other day after maybe 10 of slow "ok now let me update this file... ok now let me update this file..." it suddenly paused, looked at the pattern so far, and then decided to write a python script to do the refactoring & executed it. For some reason it considered its work done even though the files didn't even pass linters but thats' polish.
by godelski | 2025-10-01 21:29:42+00:00
Honestly it's difficult to understand exactly what you're arguing. Because I understand laymen not understanding your argument about infinities not being real (and even many HN users don't understand code is math bit a CS degree doesn't take you far in math. Some calc and maybe lin alg) but are we concerned about laymen? I too am frustrated by nonexperts having strong opinions and having difficulties updating them, but that's not a culture problem. We're on HN and we know the CS stereotypes, right?

If instead you're talking about experts then I learned about what you're talking about in my Linear 2 course in a physics undergrad and have seen the topic appear many times since even outside my own reading of set theory. The axiom of choice seems to have even entered more main stream nerd knowledge. It's very hard to learn why AoC is a problem without learning about how infinities can be abused. But honestly I don't know any person that's even an amateur mathematician that thinks infinities are physical
by jelkand | 2025-10-01 21:29:48+00:00
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by zdragnar | 2025-10-01 21:30:23+00:00
For many countries, pure renewables plus batteries only works with an international grid. In a different thread here, Germany was coming up quite a bit during the dunkelflaute, and the only way to go pure renewable is to import energy from, say, Morocco.

It does achieve potential independence from current adversaries, but only by introducing dependence on other nations instead.

Countries like the US have it a little better independence-wise, except we need (a) significant buildouts of batteries that don't rely on rare earths, because we can't mine them here for environmental reasons, and (b) massive buildouts of solar panels in regions across the country.

The upper midwest has something similar to Germany's dunkelflaute- it gets cold enough windmills may even be net negative to keep their turbines ice free, and we can go weeks under total cloud coverage.

Supporting all of that is possible, but requires overbuilding the grid to such an extent that the carbon cost of the cement and metals added to the grid would extend the payoff period quite a bit. It's definitely not a free lunch, though probably better to start now than hope for miracle cold fusion or something equally silly.
by androng | 2025-10-01 21:30:38+00:00
Location: San Francisco Bay Area

Remote: yes

Willing to relocate: California only

Technologies: C, UART, SPI, I2C, Bluetooth Low Energy (BLE), Git, Python, AVR, ARM, Altium Designer, EAGLE PCB, SketchUp, SPICE, oscilloscopes, logic analyzers, multimeters, function generators, soldering irons, power tools

Résumé/CV: https://drive.google.com/file/d/15deWAuB09VRwO2hWFmT4Xi15RTw...

Email: andrew@speedysignals.com

Linkedin: https://linkedin.com/in/androng
by ndriscoll | 2025-10-01 21:30:48+00:00
At least in the US, some grocery stores will scan IDs when someone buys alcohol. In some states they are required to do so. I would be very surprised if they didn't then store that information. As far as I know there's no law against it, and they'll gather whatever they can. Firearms dealers are required to keep information about their customers. In contrast, the recent laws here that I've looked at all make it illegal for the service to store information related to online age verification. So you actually have better privacy protections with online adult content.
by ryandrake | 2025-10-01 21:30:56+00:00
Most of my kid's friends can't even get through a feature-length movie--even one made for kids. Every time there's a lull in the action for 10 seconds or more, the phones come out (or they start talking with each other, if no phones are present). If that happens more than 3-5 times, they're pretty much checked out and usually just leave the room. It's got to be constant stimulation and/or constant dialog to keep them interested. A slow, panning shot across some scenery? Forget it.
by quintes | 2025-10-01 21:30:59+00:00
Seeking: Strategy, Technology and Architecture advisory and consultancy to startups, scaling teams or established companies / organisations.

Location: New Zealand, willing to support APAC, APJ, Australia, New Zealand and West Coast US remotely.

Remote: Yes

Willing to relocate: No

Technologies: See below.

Résumé/CV: https://architectfwd.com/about

Email: hackernews at architectfwd dot com

Need a consultant, strategic thinking, architecture or related tech advice, coaching/ mentoring for you or your team? Need governance improvement?

How could we work together? An hour, a couple of hours or something more regular but flexible/fractional? I am looking for part hours, or retainers, or work toward fully moving into a consulting / advisory capacity

Let’s figure out how to work together.

I have 20+ years solving business problems and maximising opportunities through technology in a variety of industries internationally.

My core skills are in strategy, enterprise architecture, technology architecture, consulting and advice, agile, team leadership, coaching and mentoring. Can do operating model work.

I am currently a Principal Architect. I operate in strategic advisory and technology architecture with many years in architecture and technology in the private and public sector. I know how to use enterprise architecture frameworks, practices and principles from concept stage to delivery in order to execute on strategy and how to work with product and development teams to set direction and manage product evolution.
by magospietato | 2025-10-01 21:31:22+00:00
Whitehall - the UK civil service - persists between governments in a fairly unique way. It's essentially a political entity that exists beyond democracy that has pinky-promised to be politically ambivalent.

To paraphrase an adage I've forgotten: you can skim as much shit as you like off the Thames, it'll still be a filthy river.
by ebb_earl_co | 2025-10-01 21:31:25+00:00
I like the `VARIANTS` env. var [0] to take advantage of x86_64 newer extensions if one’s processor has them.

CachyOS is a whole distro compiled with these flags, if possible, which is appealing.

[0] https://github.com/tvlabs/edge264#compiling-and-testing
by sidechaining | 2025-10-01 21:31:34+00:00
Location: Durham, NC Remote: Yes Willing to relocate: Yes (prefer East Coast) Technologies: Python, AWS, SAS, Machine Learning Résumé/CV: https://dropover.cloud/7d3662

Email: resume at elitemail.vip

A highly-skilled software engineer with 7+ years of experience specializing in AI, data engineering, backend development, and AWS infrastructure.
by Anon84 | 2025-10-01 21:31:38+00:00
Location: NYC Remote: Yes Willing to relocate: No Technologies: Machine Learning, Python, LLMs Résumé/CV: By request Website: https://www.data4sci.com GitHub: https://github.com/DataForScience/ Substack: http://data4sci.substack.com/ Email: bgoncalves@gmail.com
by timschmidt | 2025-10-01 21:31:43+00:00
> I'm an engineer not just by training, but by nature. When the only tool you have is an engineer, every problem looks like it can be solved with better engineering.

I am also an engineer. But I've spent a decade working with biologists, mathematicians, physicists, and chemists understanding and repurposing evolutionary algorithms. For complex tasks such as these, they are often our best tools.

> Similarly, it seems to me that you may be unfairly biased against man made solutions. The problems you describe are just engineering challenges. Difficult ones to be sure, but we have some very clever scientists and some very sophisticated tools that are improving at a non-linear pace. We may not crack the nut this week, but someone will eventually.

Selective breeding _is_ man made.

> Plants are also technology now. Why not a genetically modified plant that produces only the desired cannabanoids, or modified versions of the cannabanoids?

As I pointed out earlier in the thread, pure THC has worse therapeutic outcomes than the whole plant.

Purity != efficacy.

You could probably survive on protein powder and multivitamins, but no one would enjoy that.

Opiates are similar BTW. The whole poppy product provides relatively gentle rise and fall and an overall pleasant experience, whereas specific isolates can be quite harsh. It's called the entourage effect or synergistic interaction of the phytocomplex.
by dudeinhawaii | 2025-10-01 21:32:13+00:00
I've found GPT-5-Codex (the model used by default by OpenAI Codex CLI) to be superior but, as others have stated, slower.

Caveat, requires a linux environment, OSX, or WSL.

In general, I find that it will write smarter code, perform smarter refactors, and introduce less chaos into my codebase.

I'm not talking about toy codebases. I use agents on large codebases with dozens of interconnected tools and projects. Claude can be a bit of a nightmare there because it's quite myopic. People rave about it, but I think that's because they're effectively vibe-coding vastly smaller, tight-scoped things like tools and small websites.

On a larger project, you need a model to take the care to see what existing patterns you're using in your code, whether something's already been done, etc. Claude tends to be very fast but generate redundant code or comical code (let's try this function 7 different ways so that one of those ways will pass). This is junior coder bullshit. GPT-5-Codex isn't perfect but there's far far less of that. It takes maybe 5x longer but generates something that I have more confidence in.

I also see Codex using tools more in smart ways. If it's refactoring, it'll often use tools to copy code rather than re-writing the code. Re-writing code is how so many bugs have been introduced by LLMs.

I've not played with Sonnet 4.5 yet so it may have improved things!
by Clamchop | 2025-10-01 21:32:18+00:00
Calling it "the perfume industry" is a half truth. It's the flavoring industry, but it so happens that there's a lot of overlap between perfume and flavoring in terms of raw materials.

However, flavoring is a distinct profession. Besides that, very few novel compounds are allowed in food compared to fragrance. If any flavoring is synthetic in origin (which is not the same thing as novel, to be clear) then the product must be labeled as artificially flavored. If they call the product 100% juice and added flavoring is used, then that flavoring in turn has to have been sourced from the fruit.

In other words, they're using extracts from real oranges to reconstitute the flavor lost during pasteurization. They can further adjust which parts of the extract they use (called fractions and isolates) to dial in a particular flavor.
by zahlman | 2025-10-01 21:32:28+00:00
>But if I ask Python to [add up about a hundred million] [32-bit floating point numbers in the naive way], Python takes about twenty seconds anyway

Really?

$ python -m timeit -s 'import random; x = [random.random() for _ in range(100000000)]' 'sum(x)' 1 loop, best of 5: 806 msec per loop

This is on 11-year-old hardware. Even the generation isn't that slow:

$ time python -c 'import random; x = [random.random() for _ in range(100000000)]' real 0m10.942s user 0m9.590s sys 0m1.346s

Of course, Python forces the use of doubles internally. Any optimizations inherent to 32-bit floats are simply not available.
by scottlamb | 2025-10-01 21:32:36+00:00
Be careful with "they". The "zero effect" in the headline was likely written by a Register editor, two steps removed from the authors of the study. I think the quote in the fourth paragraph is more telling:

> "Overall, our metrics indicate that the broader labor market has not experienced a discernible disruption since ChatGPT’s release 33 months ago, undercutting fears that AI automation is currently eroding the demand for cognitive labor across the economy," said Martha Gimbel, Molly Kinder, Joshua Kendall, and Maddie Lee in a report summary.
by totemandtoken | 2025-10-01 21:32:45+00:00
Location: Detroit, Mi Remote: Yes, but open to onsite Willing to relocate: Yes Technologies: Python, C++, JavaScript (React, some Typescript, Node.js), Java, Résumé/CV: https://www.linkedin.com/in/nasir-sharaf/ Email: nsrsharaf7 [at] gmail.com

Hi all, my name is Nasir, I'm a software developer in the metro Detroit area looking for work where I can grow and further develop my technical skills. I'm attracted to interesting, niche projects and working with open minded people who are willing to share and coach. Please reach out at linkedin if you would like to connect
by palata | 2025-10-01 21:32:45+00:00
I do what I can with my own threat model. Actually, I probably do a lot more than what my threat model requires, just because it's interesting and for the learning experience. I don't go as far as to turn off my cell phone when not using it, but I run GrapheneOS :-).

> But it seems like others are incapable of acting on the knowledge.

That's wrong. They just don't understand and don't care to understand. They choose not to act, because they don't see a need. Which is true for many things and different groups. You care about turning off your cell phone, how much do you care about climate change or the mass extinction we are responsible for?

I would argue that the equivalent of turning off your cell phone would at the very least be to be a vegetarian. Are you, or are you "incapable of acting on the knowledge"? :-)