MurphyA/hacker-news huggingface dataset:
by akerl_ | 2025-10-29 00:36:44+00:00
I'm not asking for an intrinsic difference: I'm suggesting that if "I can install custom applications/code on this device I own" is a fundamental right, there would need to be an intrinsic difference. My personal opinion is that there is not an intrinsic difference. That "I want to do it to these devices and not those" can't be the justification for it being a right that I'm able to.
by miffy900 | 2025-10-29 00:36:56+00:00
for the longest time, no one in linux land cared about API stability or backward compatibility - then app/game developers realised if they could port a portion of Win32 to Linux via WINE, they could just target the win32 API or at least a portion of it and so long as WINE was installed, their app/game would always work. i find it a bit ironic; desktop Linux is being enabled by re-implementing APIs from another OS.
by makeitdouble | 2025-10-29 00:37:25+00:00
Commercial products usually require knowledge (expertise?), and have their own limitations. Even repairability can be an issue in a different way.

I don't know for dishwashers, commercial printers are expected to be serviced by the maker or affiliated business and getting parts as a mere peasant can be pretty complex. Surely rich people can just throw money at a contractor, but that's not what we're talking about I think (otherwise having a new one delivered everytime would also just work)
by brucehoult | 2025-10-29 00:38:03+00:00
I'm confused. You appear to be against adding new instructions, but also against picking a baseline such as RVA23 and sticking with it for a long time.

Every ISA adds new instructions over time. Exactly the same considerations apply to all of them.

Some Linux distros are still built for original AMD64 spec published in August 2000, while some now require the x86-64-v2 spec defined in 2020 but actually met by CPUs from Nehalem and Jaguar on.

The ARMv8-A ecosystem (other than Apple) seems to have been very reluctant to move past the 8.2 spec published in January 2016, even on the hardware side, and no Linux distro I'm aware of requires anything past original October 2011 ARMv8.0-A spec.
by lmm | 2025-10-29 00:38:06+00:00
> This only holds if you assume that the hiring process is already fully meritocratic (which it very clearly isn't) and that it isn't missing talented women already (which it very clearly is).

Citation needed. Certainly neither of those is "clearly".

> If hiring managers are, subconsciously or not, more likely to pick the male candidate when faced with a choice for equally capable male/female candidates then there is inherent discrimination in the process and the DEI approach balances the scale.

And if it's the opposite, as the best available evidence (not that there is any really solid evidence in this space) suggests?

I'm all for ensuring that everyone gets a fair chance that reflects their skills and experience, regardless of personal characteristics. As far as I can see DEI initiatives are working against that.
by BLKNSLVR | 2025-10-29 00:38:56+00:00
I'll have to get back to you. I had to go through the process three or four times to get it to stick across reboots and not leave me with a useless TV just showing a black screen (I had a panic moment when that happened).

You can ask Perplexity, but this doesn't give the adb commands to disable the default launcher (which you need to do so that it doesn't override what the user has chosen upon reboot): https://www.perplexity.ai/search/how-do-i-install-project-iv...

I should also mention: This may render some of the TV remote shortcut buttons useless. There's an app that's meant to help with this, but I've found it unreliable.

I'll find my notes tonight...
by BoorishBears | 2025-10-29 00:39:01+00:00
No one is sleeping on nano-banana/Gemini Flash, it's highly over-tuned for editing vs novel generation and maxes out at a pretty low resolution.

Seedream 4.0 is somewhat slept on for being 4k at the same cost as nano-banana. It's not as great at perfect 1:1 edits, but it's aesthetics are much better and it's significantly more reliable in production for me.

Models with LLM backbones/omni-modal models are not rare anymore, even Qwen Image Edit is out there for open-weights.
by pfisherman | 2025-10-29 00:39:33+00:00
This article kind of grinds my gears. I feel like there is an unstated assumption that people in pharma R&D are idiots and haven’t thought of this stuff.

Pharma companies care very much about off target effects. Molecules get screened against tox targets, and a bad tox readout can be a death sentence for an entire program. And you need to look at the toxicity of major metabolites too.

One of the major value propositions of non small molecule modalities like biologics is specificity, and alternative metabolism pathways; no need to worry about the CYPs.

Another thing they fail to account for is volume of distribution. Does it matter if it hits some receptor only expressed in microglia if it can’t cross the blood brain barrier?

Also the reason why off targets for a lot of FDA approved drugs are unknown is because they were approved in the steampunk industrial era.

To me this whole article reads like an advertisement for a screening assay.
by throw0101c | 2025-10-29 00:41:01+00:00
> While a new CPU alone isn’t a thrilling update, it’s important that they do these regularly so consumers looking to buy aren’t forced to buy a 3 year old product with no idea when a refresh will come.

Also: incremental updates add up.

A (e.g.) 7% increase from one year to the next isn't a big deal, but +7%, +7%, +7%, …, adds up when you finally come up for a tech refresh after 3-5 years.
by tinmith | 2025-10-29 00:41:40+00:00
The people who build proper home cockpits inside real aircraft, especially interfacing with old aircraft hardware, are always very impressive. This takes a lot of time, dedication, and reverse engineering.

But it is also easy to get started at home. Using some 42 inch televisions and old Android tablets, you can replicate a lot of the immersion very easily and have fun, see if you like it. Check out my open source projects and free apps for X-Plane and more details on building your own immersive flight simulator experience: https://www.waynepiekarski.net/projects/xplane.htm

Although be aware, these projects tend to turn more into an adventure building than actually flying much :)
by porphyra | 2025-10-29 00:42:09+00:00
I maintain a personal dotfiles repo on github, and when I start at a new job etc, I just git clone my dotfiles repo and then run ./setup.sh and everything is set up nicely with my fonts, colors, and stuff. It didn't take much effort at all and I get to use what I like. And I haven't tweaked my dotfile in years.
by opan | 2025-10-29 00:42:23+00:00
I wish this viewpoint were more common/well-known. Somehow people get it in their head that people are tinkering with all their stuff constantly and never working, but just as TFA says, you'll have configs that haven't changed in over 6 months and are customized to your liking so you can work more efficiently and comfortably. Get a new PC? rsync configs over, or git clone your dotfiles repo or whatever. The work you put in doesn't disappear.
by 201984 | 2025-10-29 00:43:18+00:00
Not that dissimilar to Wirecutter's advice on appliances: either buy the cheapest of the cheap because it'll have the fewest parts that can break, or the most expensive since it'll be built with high quality components and hopefully be repairable.

https://www.nytimes.com/wirecutter/reviews/modern-appliances...
by qiqitori | 2025-10-29 00:43:41+00:00
I think your position is valid.

Note: Apple restricts apps uploaded with Xcode, (depending on how it is signed I believe) to 7 days or 1 year. adb currently doesn't have this limit.

But what if they find that somebody made 'sideloading' 'too easy' again. E.g. somebody could come up with the idea of running adb or an adb emulator on another phone, or even a small hardware dongle, integrating it with a pretty UI that looks like a regular app shop. Then their currently proposed new rule would become ineffective and due to whatever thought process they arrived at their current conclusion, could place similar limits on adb.
by hollerith | 2025-10-29 00:44:06+00:00
>The US presidential candidates are appointed

Is this really true? Aren't the outcome of primary elections much much more important in determining who will be the Republican and Democratic presidential nominees than elected officials and party officials are?

Specifically, an unreliable source that gives fast answers to questions says that a candidate who wins enough primaries to get over half the delegates is almost certain to be the presidential nominee for his or her party.
by frikskit | 2025-10-29 00:44:47+00:00
Net migration US/Ireland is positive to Ireland.

UK numbers yes, though maybe gloomy weather plays a role? Just kidding. That said, Brits are slightly more likely to move to Spain than US despite it being a tiny country in comparison and not necessarily easier to move to after Brexit.

Spain, not sure. It’s tricky to compare since non immigrant Spanish speaking population in US is probably significantly lower than Spaniards speaking English. But yeah, you probably have a point on that one.
by SpicyUme | 2025-10-29 00:45:14+00:00
I struggle with the music one. I listen to a lot of different music, used see live music at least once a week, and have some strong opinions. I still struggle to explain music to others or why I enjoy certain artists/songs.

It is like the details don't register in a usable way, where one of my good friends will tell me he likes a band because of the guitar tone or the drummer's technique or something else that I struggle to explain or even pick out of the music. I wish I could explain my preference better.
by shaggie76 | 2025-10-29 00:46:07+00:00
My first thought was this blog article I saw on HN a while back:

https://lukeplant.me.uk/blog/posts/should-we-use-llms-for-ch...

He argued, persuasively I thought, that "this is an area where truthfulness is of paramount importance" and consequently would be extremely ill-suited to AI.
by Brian_K_White | 2025-10-29 00:46:25+00:00
Tinkering with fonts is the only way to get fonts that improve legibility by replacing ambiguous glyphs with unabiguoius. ie programmer fonts. Every day it boggles my mind that password managers use fonts that don't distinguish 1Il| 0O etc. cut & paste does not help when you need to speak them into a phone or type them into some other device. Same applies to simple part numbers, serial numbers etc, just all data.

Something I say about complainers applies here:

In the entire history of the world not one thing has ever gotten better by accepting something as it is.

Go ahead and never tinker, but don't delude yourslef it's a virtue. It's merely something you're free to do because it doesn't actively harm anyone else.
by stavros | 2025-10-29 00:46:46+00:00
Decades ago, an old friend told me "I became a coffee expert, I learned everything there is to learn about beans, the ways to prepare them, the chemistry that goes into it, and now I can only enjoy a cup of coffee prepared by the most expensive machines from the most expensive beans. The shit part is that I enjoy it just as much as I enjoyed my shitty supermarket coffee back when I didn't know anything about coffee."

That advice has stuck with me, and I try to have the least taste I can. I use $20 headphones and a $200 TV because I can't tell what "good" is, and I enjoy music and movies as much as my friends with $600 headphones and $3k TVs do.
by derefr | 2025-10-29 00:48:13+00:00
I mean, my point was that there are actually three different ways you can spend a lot of money on a fridge, and it's a lot like with PCs.

You can buy:

• a big ugly powerful repairable/durable industrial one (like a server);

• an average-sized, somewhat-fancy (because high-trim), repairable/durable commercial one (like a workstation);

• or an average-sized fancy "aesthetic" one, made by a design company rather than an appliance company, that isn't repairable or durable (like one of those bespoke "sleeper desk PCs.")

The same goes for most things you can spend a lot of money on. A sound system, a vacuum cleaner, a car, etc. In each of these cases, "premium" has these same three distinct meanings. None of which involve showing you ads. But all of which have their own trade-offs. And all of which are usually quite a bit more expensive (each for their own reasons) than the highest-trim product sold directly to the average consumer by what you'd think of as a "consumer brand."
by guy_5676 | 2025-10-29 00:49:33+00:00
Very uncharitable way to phrase that, American second language prevalance is similar to other English dominant countries like the UK or the Australia.

Americans in general don't speak as many languages as Europeans because they already speak arguably the most useful language. I've lived in 20 countries, and in every single one for them I've been able to find someone who speaks English. People are so ingrained with the need to know the language that I've actually met people who are embarrassed about their English talking to me in their own native country.

If you grew up speaking Greek, Romanian, or even something like Italian, this absolutely would not be true. Maybe you could find a person or two to talk to, but definitely not dozens casually in everyday situations. So you have to learn multiple languages by necessity. And since European countries are so small, close together and all have their own languages, you also end up picking up your neighbors languages.
by adventured | 2025-10-29 00:49:48+00:00
Bezos is calculating his years remaining with regards to Blue Origin and that a given President can cause severe disruption to the pathway Bezos has in mind for his organization. I'm sure his ideal would be to finely balance WaPo's reputation and his need to placate the current President, and I'm also certain with Trump it's not doable (so he'll sacrifice some of WaPo's reputation to keep progress going on Blue Origin during the Trump years).
by asveikau | 2025-10-29 00:50:23+00:00
This community has pockets of people who like authoritarian control, and genuinely believe in Apple or Google Play as some kind of superego that they need to defend, that they believe is protecting us.

This surfaces in many types of discussions, including discussions where they may be prompted to defend the locked down nature of mobile devices.

I say it's just pockets. A vocal pocket. It's not everyone here. But it elicits comments justifying that stuff, which can feel surprising for those who don't share those views.
by fsniper | 2025-10-29 00:50:49+00:00
Most of the time, people without weight problems, or who has bodies that acts in favor of calorie restriction likes to reject claims of this kind.

If I had a nickel everytime I heard "You have to be doing something wrong".

However science is not clear cut, our bodies and genetics are less so. My personal experience also suggest trying to limit calories is not working for me either. It’s absolutely more complex than that. And I managed to lose 45 kgs to 72 once , and recently around 20 to 105. As this implies yes it was not long term at all. ( 3-4 years of slim body ).

Psychology, Hormones, Stress, Sedantal everyday life, eating habit changes has different effects and if the stars don’t align the correct way I can’t lose weight, or keep doing it. Particularly trying to limit calories with conventional ways requires steel nerves which also affects everyday life inversely.

In my experience this satiety looks like has some - small or big- effect.

There are different effects like NEAT, p-ratios or Adaptive Thermogenesis. As google gemini told me recently, (check for facts as I didn’t do much) there are few theories working towards understanding these body responses to similar diets like set point theory, or thrifty gene theory.

So instead of rejecting these claims perhaps we need to look with more accepting eyes to understand these kinds of calori restriction responses for different gene compositions.
by znort_ | 2025-10-29 00:52:56+00:00
>You have the right to install whatever you want on your computer, regardless of whether that computer is on your desk or in your pocket. That's a hill I'll die on. I'm dismayed to see that this sentiment is not more widespread in this of all communities.

agreed, but i'm not going to die on any hill. i don't see much point in this discussion, these corps will do whatever they like. for me it is simple: iphone never was an option precisely because of this reason, and i've been quite content with android, but i don't think my current smartphone will run android for much longer, and the next one will definitely not.
by pessimizer | 2025-10-29 00:53:31+00:00
> The only reason Google has decided to lock-down Android is because of apps like ICEblock and the ability for anonymous individuals to mass distribute information that governments do not like.

Nah. The only reason Google has decided to lock-down Android is because they think they can get away with it. They would have done it from the first minute except that not doing it gave them a competitive advantage in the market over Apple - back when pretending to be into FOSS and to "not be evil" was a major part of their marketing. They're ready to make the move. If it fails, they'll try to make the move again a few years from now. They don't give a shit about ICE or whatever.
by CamperBob2 | 2025-10-29 00:54:33+00:00
Topical: https://hex.ooo/library/nine_billion_names_of_god.html

“Your Mark V Computer can carry out any routine mathematical operation involving up to ten digits. However, for our work we are interested in letters, not numbers. As we wish you to modify the output circuits, the machine will be printing words, not columns of figures.”
by iroger321 | 2025-10-29 00:54:41+00:00
Honestly I feel like this is the last big wall for a lot of creative pros. Affinity Photo is closing in on Photoshop-level capability, and things like Bottles + Wine can actually run older versions of Creative Cloud surprisingly well now.

The real issue isn’t capability but just adoption (IMO): most studios and agencies are chained to Adobe’s ecosystem. If even one major studio publicly switched pipelines to Linux, the floodgates would probably open to actually allow this.
by heavyset_go | 2025-10-29 00:54:41+00:00
This is the way I am with hiking and biking. I genuinely enjoy them, but I have a tendency to really get into the weeds with things I'm interested in and ruining the fun.

I purposely just go for hikes for the sake of it, and refuse to give in and buy anything other than a generic bike, even though a part of me really wants __ hardware. If I buy it, that will be the point of no return for becoming a bike nerd and I'll start caring about stuff I don't want to care about.

Now computers, I've learned a million ways to hate them, and learn new ways to hate them every day. Not with bikes, though :)
by xenophonf | 2025-10-29 00:55:05+00:00
> While internal modules and libraries should be kept as generic as possible, external-facing components, on the other hand, are a good place to put business-specific domain logic. External-facing components here refer not only to views but also to any kind of externally-triggered handlers including external API endpoints (e.g. HTTP/REST API handlers).

That goes against every bit of advice and training I've ever gotten, not to mention my experience designing, testing, and implementing APIs. Business logic belongs in the data model because of course the rules for doing things go with the things they operate on. API endpoints should limit themselves to access control, serialization, and validation/deserialization. Business logic in the endpoint handler—or worse, in the user interface—mixes up concerns in ways that are difficult to validate and maintain.
by kragen | 2025-10-29 00:55:08+00:00
A lot of truly rich people live in houses that haven't been on the market for generations, or centuries, or ever. The particular hectomillionaire's vacation home I spent a few months in wasn't one of those (he's self-made) but also didn't have the kinds of features you're talking about at all. No separate hidden "main fridge", no butler's pantry, no second kitchen, no kitchen island, no great rooms, no panoramic picturesque views. It did have a dining room and bedrooms, though. It had been built as a small hotel, so it had five bedrooms (on the upper floor), an atrium, and a small swimming pool. From the street it just looked like a regular house. You could walk from the bedroom overlooking the swimming pool down the hall, down the stairs, down the other hall and dining room, across the patio, up the other stairs, and into the last bedroom, in about two minutes.
by mynameisash | 2025-10-29 00:55:59+00:00
I agree with you. The "smart" in "smart appliance" to me always indicates some bullshit I definitely don't want.

What's especially frustrating to me is that my appliances that should have a delay on them don't; specifically, my dryer and dishwasher should be able to delay until later in the evening when my electricity rates go down. Instead, I have to get them ready and press the button with my thumb like my parents did with their appliances 40 years ago.

But hey! These things can chew up gigabytes of bandwidth[0], so there's that.

[0] https://www.reddit.com/r/smarthome/comments/mn3p6c/lg_dryer_...
by vunderba | 2025-10-29 00:56:04+00:00
> That said, I am surprised Seedream 4.0 beat it in these tests.

OP here. While Seedream did have the edge in adherence it also tends to introduce slight (but noticeable) color gradation changes. It's not a huge deal for me, but it might be for other people depending on their goals in which case NanoBanana would be the better choice.
by colordrops | 2025-10-29 00:57:57+00:00
Will it though? The human mind can hold less context at any one time than even a mediocre LLM. The problem isn't architecture. It's capturing context. Most of it is in a bunch of people's heads and encoded in the physical world. Once it's digitized and accessible through search, RAG, or whatever, the LLM will be able to use it effectively.
by abhishaike | 2025-10-29 00:58:22+00:00
>molecules get screened against tox targets

sure! i cover this in the essay, the purpose of this dataset is not just toxicity, but repurposing also

>toxicity of major metabolites

this is planned (and also explicitly mentioned in the article)

>no need to worry about CYP’s

again, this is about more than just toxicity

>volume of distribution

i suppose, but this feels like a strange point to raise. this dataset doesnt account for a lot of things, no biological dataset does

>advertisement

to some degree: it is! but it is also one that is free for academic usage and the only one of its kind accessible to smaller biopharmas
by LexiMax | 2025-10-29 01:00:03+00:00
> exemplars of excellent user moderation

This is a contradiction. There's no such thing, only shades of bad, and HN has about the worst possible implementation.

For what it's worth, I didn't flag or downvote you. YC is seemingly fine with your behavior, and I've seen much worse out of people who have been here longer. I'd rather your mask-off rants be out in the open than swept under the rug.