MurphyA/hacker-news huggingface dataset:
by JumpCrisscross | 2025-10-16 04:41:17+00:00
> Can you cite an example or source for this?

“We previously reconstructed a 1,000-year-old remedy containing onion, garlic, wine, and bile salts, known as ‘Bald’s eyesalve’, and showed it had promising antibacterial activity. In this current paper, we have found this bactericidal activity extends to a range of Gram-negative and Gram-positive wound pathogens in planktonic culture and, crucially, that this activity is maintained against Acinetobacter baumannii, Stenotrophomonas maltophilia, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes in a soft-tissue wound biofilm model” [1].

> How could we be losing if medicine can afford to "wait out" a strain?

In general, “mutations that confer larger” resistance “are more costly” in terms of fitness [2].

Absent the selection pressure of a particular antibiotic, the bugs without that resistance generally outcompete the ones weaving chainmail against Tomahawks.

[1] https://www.nature.com/articles/s41598-020-69273-8

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC4380921/
by antisthenes | 2025-10-16 04:43:14+00:00
To be fair to the OP, the median (so lower than average) salary for a single person with a bachelor's degree (in USA) is ~$80,000, give or take a few bucks.

The average is likely higher, and then higher again for higher COL areas.

So it's not unreasonable for OP to expect to start at this level, and work their way up to $150k over the next 5-7 years.
by m_sahaf | 2025-10-16 04:43:41+00:00
It's a repeat complaint from the same person who admits bringing it up before. The way they framed their complaint is, again, snide.

> That’s a long way beyond exasperation, that’s a massive overreaction.

Your reaction to Francis is _the_ overreaction. Francis simply said to OP to put their money where their mouth is. The "slander" comment comes later as a general statement on why this subject has become annoying.

Stop being hung up on Francis' response. The niche feature was discussed at length multiple times. You're welcome to search the web for all the conversations we had on the subject. Caddy has been around for 11 years. We've seen this subject more than you've seen it brought up. Again, OP referenced the discussion on the issue tracker in one of the earlier times they brought it up. They _admit_ it's niche. What's the point of continuously bringing it up?
by akshayka | 2025-10-16 04:43:49+00:00
Hi! Thanks for your interest. marimo is much more than that — unlike traditional notebooks, marimo is "reactive", meaning it models notebooks as dataflow graphs and keeps code an outputs in sync. Moreover, marimo notebooks are not "just notebooks". They can be seamlessly run as interactive web apps or as Python scripts.

Here is our original ShowHN post that explains what marimo is all about: https://news.ycombinator.com/item?id=38971966

Blog that goes deeper: https://marimo.io/blog/lessons-learned
by erentz | 2025-10-16 04:43:59+00:00
> And then there's little bugs everywhere that just grind away at you on a daily basis:

When I create a new folder or file in a directory in explorer it hangs for a bit and doesn’t show up unless I click refresh. Ditto if I save a file to a directory that is open in explorer.

Thinking about trying to get a copy of Win 10 IoT LTSC instead at this point.
by jpk2f2 | 2025-10-16 04:44:07+00:00
I largely agree with your points, but in this context -

* A microsoft account is only needed for Windows 11 Home. A "semi-power user" is hopefully not using that edition of Windows...

* I'm also greatly annoyed by the right click - but holding shift when right-clicking opens the expected menu, removing the extra click requirement.

Some of my own annoyances though:

* The taskbar/windows button seems to just...crash...sometimes. It'll eventually restart, but extremely annoying. Left clicking taskbar icons still works, but right clicks or the start button don't work as expected.

* Additional clicks to change audio devices...drives me crazy on my main system.

* I like the autosaving aspect of notepad, but they've killed the main reason I used it - an instantaneous, lightweight text app. It's still quick, but is noticeably slower.

* Settings and Control Panel is still a mess, and even less usable than Windows 10 was.
by candeira | 2025-10-16 04:44:13+00:00
I could be wrong about this but, if I had a guess, I'd say the 24GB M5 chips/systems exist due to binning.

Apple is designing and manufacturing a chip/chipset/system with 32GB with integrated memory. During QA, parts that have one non-conformant 8GB internal module out of the four are reused in a cheaper (but still functional) 24GB product line rather than thrown away.

Market segmentation also has its hand in how the final products are priced and sold, but my strong guess is that, if Apple could produce 32GB systems with perfect yield, they would, and the 24GB system would not exist.
by nobody9999 | 2025-10-16 04:44:23+00:00
>you seem to be up on GPL2 , what happens when someone packages distros on disk or stick, and sells them for profit ? thats something to be aware of as well.

Assuming that someone has customers, they have a viable business model, that's what happens.

That was, in fact, the business model of most Linux distros before we were all terminally online.

Don't be shy. Tell us what you're concerned about and why you think that's an issue.

Are you implying some sort of illegality or breach of license?
by cratermoon | 2025-10-16 04:44:50+00:00
> They make the claim that solo and small firms are the most likely to file AI hallucinations because they represent 50% and 40% of the instances of legal briefs with hallucinations.

Show me where she makes any predictive claims about likelihood. The analysis find that of the cases where AI was used, 90% are either solo practices or small firms. It does not conclude that there's a 90% chance a given claim using AI was done by solo or small firm, or make any other assertions about rates.
by silisili | 2025-10-16 04:45:02+00:00
Oh goodness yes. I was forced from Linux to W11 Pro for my new job. Use wsl2 they said, it'll be fine.

And wsl2 is mostly fine. But that doesn't stop the rest of the OS from being a dumpster fire. Why is it asking me to install or play Xbox games constantly? It feels like I have malware...
by jpk2f2 | 2025-10-16 04:47:30+00:00
You don't need IoT, just the normal LTSC (2027, and then security updates until 2032, iirc). And there are easy ways to swap to it, present on GitHub...

Main downside is other applications dropping support for 10, if relevant. I only swapped my main system due to Fusion 360 notifying me they were dropping 10 in January 2026.
by francislavoie | 2025-10-16 04:47:57+00:00
I thought I was clear enough about this already, but clearly not: I encourage anyone who believes there's a bug with Caddy to report it to us on GitHub, where bug reports belong, where we can have focused discussion about it and see it to its natural conclusion. I do not discriminate bug reports based on who makes it.

An HN thread is not the place to report a bug. Nor do I think it's fair to form opinions about project maintenance (which doesn't happen on HN) based on comments in HN.
by orangecat | 2025-10-16 04:48:51+00:00
See https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h... for an IMO compelling argument that amyloid really is the underlying cause. The theory is that amyloid buildup causes misfolded tau proteins which cause the cognitive damage. So reducing amyloid in people already suffering from Alzheimer's doesn't do much because they already have excessive tau; at best it might slow down the progression.
by baka367 | 2025-10-16 04:48:52+00:00
It was different for me. I tried to move from Windows to Linux multiple times, but my Dell just refused to run it reliably no matter what. After fidling with multiple distros I finally bit the bullet and went for a mac. I cant be more happier to have a Linux experience without the Linux pains.

Note that there certainly are quirks around arm64, however, coming from windows, i am no stranger to have to deal with such issues so they bother me less.

The best thing is, that i can confidently put mac into my backpack without worries of it performing a suicide due to not-fully-sleeping (common windowns issue)
by m_sahaf | 2025-10-16 04:48:52+00:00
> If that person found another problem with Caddy, I think they are less likely to report it to you because of this.

Given they're aware of previous discussion and the stance on the feature request, I don't think they're deterred by the discussion here. Your addition of fuel to fire here is the very thing that's not helping.

> If they did report it, I would think you are very likely to dismiss it because of who they are, not the contents of the bug report.

That's a huge assumption on your behalf.
by daxfohl | 2025-10-16 04:49:52+00:00
Reading the article, I don't think it has AI. They've just made the tools in a way that AI assistants can also use them, and so fix linting errors without anyone needing to fine-tune the LLM on the syntax.

That's actually pretty slick. I've been wondering how we could avoid blocking innovation in programming languages because of the death cycle of "no training data on language -> LLM can't learn language -> Assistant can't code language -> nobody uses language -> no training data on language".
by drivebyhooting | 2025-10-16 04:49:53+00:00
There are plenty of studies. Formula is convenient but it is deficient. If it were such a perfect replacement, why do parents go to such length as breast feed, pump, or get donor milk?

Breast feeding increases IQ: https://pubmed.ncbi.nlm.nih.gov/26211556/

Formula causes obesity and diabetes: https://pmc.ncbi.nlm.nih.gov/articles/PMC2812877/

Breast feeding decreases infant mortality: https://bmcpublichealth.biomedcentral.com/articles/10.1186/1...

You can do more of your own research if you want to be convinced. You can ignore it if you don’t like the sound of it.
by kqr | 2025-10-16 04:50:02+00:00
The important part for me is that the experience is legitimate, and secondarily that it's well written. The problem for me with LLM-written texts are that they're rarely very well written, and sometimes unauthentic.

If we had really good AI writing, I wouldn't mind if poor authors used that to improve how they communicate. But today's crop of AI are not that good writers.
by beeflet | 2025-10-16 04:51:27+00:00
they are not incompatible. You can have secure boot and FDE for both linux and windows on the same system.

Just put linux's boot drive on a removable USB that has boot priority over the builtin drive. Then configure UEFI secure boot so that it works for both windows and your custom keys.

https://wiki.gentoo.org/wiki/User:Sakaki/Sakaki%27s_EFI_Inst...

This setup has the added benefit of making it so that windows can't overwrite your linux boot drive, but from linux you can still access your disk from disklocker
by tabbott | 2025-10-16 04:52:32+00:00
I'm sure there's subtle details to manage here. But "You can exfiltrate data be opening a browser" is a weak argument: One can display the URL to be opened to the user if such an Internet-limited app asks to open a browser, or decide that apps that aren't allowed to use the Internet also aren't allowed to open a browser.

I think there's ways to manage the communication with users around which cases it is surprising/suspicious for the app to require that functionality. Personally, I don't love the model that apps ask for certain permissions but aren't required to explain in a way that can be verified by app store reviewers what they need those permissions for.

And even if one doesn't want every consumer to have to explicitly consent to the permission, it seems to me like you could still have an opt-out mechanism, so that the paranoid among us can implement a more restrictive policy, rather than giving up on the idea of having such a permission entirely.
by JumpCrisscross | 2025-10-16 04:52:54+00:00
AI lawyers, wielded by plaintiffs, are a godsend to defendants.

I’ve seen tens of startups, particularly in SF, who would routinely settle employment disputes, who now get complaints fucked to the tee by hallucinations that tank singularly the plaintiffs’ otherwise-winnable cases. (Crazier, these were traditionally contingency cases.)
by Dylan16807 | 2025-10-16 04:53:40+00:00
To prove the claim we need to see that the salve is useful and that it used to be less useful because of resistance. Is that proven somewhere? This just looks like a "new" antibiotic.

And the more important part is losing resistance in a meaningful timeframe, much smaller than 1000 years. Also the relevant genes can't be easy to reactivate.
by alganet | 2025-10-16 04:54:31+00:00
You're trying to deflect the discussion into a polemic tarpit. That's not going to work.

I do not endorse the view that covid was engineered. Also, I consider it to be unrelated to what I am concerned about, and I will kindly explain it to you:

Traditional labs work with the wet stuff. And there are a lot of safeguards (the levels you mentioned didn't came out of thin air). Of course I am in favor of enforcing the existing safeguards to the most ethical levels possible.

However, when I say that I am concerned about AI being used to circumvent international agreements, I am talking about loopholes that could allow progress in the development of bioweapons without the use of wet labs. For example, by carefully weaving around international rules and doing the development using simulations, which can bypass outdated assumptions that didn't foresaw that this could be possible when they were conceived.

This is not new. For example, many people were concerned about research on fusion energy related to compressing fuel pellets, which could be seen as a way of weaving around international treatises on the development of precursor components to more powerful nuclear weapons (better triggers, smaller warheads, all kinds of nasty things).
by klinch | 2025-10-16 04:56:05+00:00
Now I'm wondering which of these extensions and strategies are employed by mainstream mail clients like Thunderbird, Apple Mail and Outlook?

I'm currently doing remote work from a location with an instable connection. Naturally I expected mails to work well in an async fashion, but instead... everything is really janky and I'm always unsure whether actions like moving an mail to a different actually 'went through' without loosing any mails.
by alganet | 2025-10-16 04:57:12+00:00
Covid is irrelevant to the discussion I opened. You're trying to steer the discussion into a place that will lead us nowhere because there's too many artificial polemics around it.

The only thing to be said about it that resonates with what I'm concerned with is that anyone that is good in the head wants better international oversight on potential bioweapons development.
by ip26 | 2025-10-16 04:57:32+00:00
The sales volumes of the 1TB+ models has got to be fairly low, which makes this fascinating. Since they are being somewhat quiet about it (rather than trumpeting "the 1TB+ models are even faster!") it suggests the P-cores don't yield well enough to support 4 P-cores in the 256GB and 512GB SKUs.
by repiret | 2025-10-16 04:57:48+00:00
But most people don't want to enter a password, and if you make people enter a password too much, they'll choose terrible passwords and put them on a sticky note. Windows Hello can only be done securely with a TPM. A server that I want to turn back on all by itself after a power outage can only be done securely with a TPM.

I want a TPM in my computer so I can have the security and convenience. Yes, it's another point of failure. But I need backups in case the hard drive fails anyway. And besides, the OS can be designed so I can enter a password if I need to use the drive without the TPM.
by kjs3 | 2025-10-16 04:57:57+00:00
Kinda overblown. Every country I've ever been to (not all, more than most) has a hard distinction between "you here for fun?" and "you here for business?". So many hours negotiating paperwork the 'for business' line.

Dude went for business (he's an 'influencer', and therefore special), advertised on his channels he was there for business, and booked multiple, money making, in-country events (with advertising).

On a tourist visa.

Well, yes, you're going to have a bad time with immigration pretty much whereever you go.
by AnthonyMouse | 2025-10-16 04:58:36+00:00
> The only “evidence” they give that GB6 is “trash” is that it doesn’t show increasing performance with more and more cores with certain tests. The obvious rejoinder is that GB6 is working perfectly well in testing that use case and those high core processors do not provide any benefit in that scenario.

The problem with this rejoinder is, of course, that you are then testing applications that don't use more cores while calling it a "multi-core" test. That's the purpose of the single core test.

Meanwhile "most consumer programs" do use multiple cores, especially the ones you'd actually be waiting on. 7zip, encryption, Blender, video and photo editing, code compiles, etc. all use many cores. Even the demon scourge JavaScript has had thread pools for a while now and on top of that browsers give each tab its own process.

It also ignores how people actually use computers. You're listening to music with 30 browser tabs open while playing a video game and the OS is doing updates in the background. Even if the game would only use 6 cores by itself, that's not what's happening.
by taurath | 2025-10-16 04:58:53+00:00
Yea but what are you "doing" when you're imagining stuff into the future - you're running some sort of prediction based on the patterns you see in the present. You're planning out moves before you execute them. The biggest difference is accuracy and breadth of simultaneous tracking, and it is relatively difficult to tell when its a good time to slow react or fast react.
by beeflet | 2025-10-16 04:59:35+00:00
Not really.

On linux, you have OpenSCAD (which is okay for some applications) and you have FreeCAD (which sucks imo). Right now, I just use OnShape which works in my web browser and is similar to SOLIDWORKS (and it's $0 for students).

In the future I will try running windows CAD under linux using kvm and this: https://github.com/casualsnek/cassowary
by troupo | 2025-10-16 05:00:00+00:00
Having scrolled through several pages of your complaining about idiots on HN or discussing a yet another AI tool, I guess this is it: https://sweetistics.com/ ? Something you couldn't link in the article for some reason?

I've scrolled bit more. I think in the past 50-100 tweets you only wrote thee talking about this, one of them proudly showing a mistake (invalid tweets containing the same text): https://x.com/steipete/status/1978229441802162548

So, I have to follow you on twitter and sift through garbage indistinguishable from all such "look how great is codex" and "this is my shamanic ritual that works I promise" to maybe see something you work on.

No thank you. I will make my judgement from the long-form article you posted.

And, as I said: depending on actual functionality, after burning $1000 a month on tokens you may actually have a fully functioning app in React + Typescript with little human supervision. I might do the same for anything Twitter-related because I couldn't be arsed to work with Twitter or Twitter APIs.
by AngryData | 2025-10-16 05:01:28+00:00
Ehh, that isn't that far off to me. You have to be pretty dang built to go over that without carrying a decent amount of fat, and im saying that as someone 6'1" and in the trades. Someone can both be built strong and still be carrying around a lot of extra fat, even if they appear well muscled; muscle in itself can hold/hide a decent amount of fat.
by more_corn | 2025-10-16 05:02:49+00:00
Are you really trying to suggest that consumer reports, the most trustworthy consumer advocate of all time is setting unreasonable safety standards?

The FDA is known to set acceptable levels too high especially for lead. The scientific consensus is clear, there is no amount of lead that is safe. If you’re regularly consuming products that contain lead you should stop immediately. If this suggestion makes you frustrated, angry or otherwise disturbed, perhaps you’re experiencing symptoms of lead exposure.
by mk89 | 2025-10-16 05:04:04+00:00
> shows that EU desperately needs to become a country by its own right

And what will be the language spoken in this country? German, I guess, of French? Or English, ironically the language of the only country who left EU? And most importantly of all, what about taxes? That's another EU war right there.

More than a country by its own right, we need less regulations, more freedom of trading, but that's pretty much it. Leave it to the countries to innovate and how. Some regulations are not bad, like the USB stuff, but countries should be free to choose how to do things, without committing to either long term nonsense goals nor to force some countries to accept some things their people don't agree with - in the name of xyz.

EU as a single country means not understanding a single bit of our EU history, of what makes us Europeans, rather than Americans, Indians or Chinese.
by notmyjob | 2025-10-16 05:04:29+00:00
At any level above 100k, the 15k extra per year for h1b workers the admin promised isn’t a meaningful barrier to h1b abuse, so you’ll have to compete with the entire planet and most of those foreign workers will come from terrible third world scammer filled hellholes that nobody would want to have to return to if their h1b gig gets canceled. Meaning your competing with quasi-slave labor.

If you go for lower paying jobs you will be treated better and have much better results without all that h1b soft slavery culture and exploitation, but alas you’ll never be able to live like a prop13’d boomer homeowner on such a salary unless you leave this failed state and move somewhere with enough political diversity to ensure a functional government. You can’t surf in Denver so you’ll have to make a hard choice or pick up a new hobby like snowboarding.
by dylan604 | 2025-10-16 05:04:50+00:00
why people continue to misunderstand this befuddles me. If you bought a budget PSU, then who knows what the voltages really are coming down the +3/+5v lines. You hope they are only +3/+5, but what happens when the power dips. Is the circuitry in the bargain priced PSU going to keep the voltages within tolerance, or do they even have the necessary caps in place to handle the slightest change in mains? we've seen way too meany tear downs to show that's not a reliable thing to bank your gear on.
by beeflet | 2025-10-16 05:05:20+00:00
>Windows Hello can only be done securely with a TPM

I think in general biometrics are in the same ballpark as low-entropy passwords. IDK, I personally have no faith in trusted computing hardware because it can be broken with the right equipment. You're right that it can be used alongside ordinary security measures, but I just think it encourages putting your eggs into a cryptographicially-weak hardware-strong basket (which represents a downgrade because crypto is stronger than hw).

>A server that I want to turn back on all by itself after a power outage can only be done securely with a TPM.

Can you describe how this prevents a MITM attack? I assume you mean a remote server? I've heard of colocation setups like this, but I think they rely on a couple of unstated assumptions.