by westurner | 2025-10-04 16:16:08+00:00
Though eating them will not solve cancer,

And, I've been chatting with 2.5pro about this, so:

/? which animals don't get cancer? https://www.google.com/search?q=Bats%2C+mole+rats%2C+horses%...

Bats (extra copies of the p53 gene, immune system, survival adaptations to atmospheric radiation exposure, high telomerase activity), Elephants (extra copies of p53), Mole rats (High molecular mass hyaluronan (HMM-HA) regulating sugar, contact inhibition), Blind mole rats (HMM-HA, protein that causes (apoptotic?) cell death)), Horses, Cows (BLV resistance, general resistance), Bowhead whales (prevention by DNA repair, CIRBP and RPA2, live to 200), Squirrels (hypersensitive cell monitoring, high telomerase activity,), and Tasmanian devils (DFTD resistance adaptation) are all cancer resistant?

If there are natural food sources that treat or inhibit cancer, and humans unwittingly were eating such foods until modern times, could it be that humans have prevented adaptation by supplementation (a support that has collapsed as modern diets have changed)?

> [... list of anti-inflammatory diet foods]

How exposed to CPMV Cowpea Mosaic Virus are humans dietarily in modern and in ancient times? CPMV causes a IFN response?

(CPMV is highly prevalent in cowpeas and black-eyed peas (which are "good luck"))

> Antibody evidence: Studies have tested patient sera for antibodies against CPMV and found that over 50% of tested samples were positive, indicating past exposure. [...] The consistent, low-level dietary exposure to CPMV over human history, and its ability to trigger an IFN response without causing infection, could have provided a form of regular, passive immune stimulation. [...]

> Despite being a plant virus, CPMV is recognized by the mammalian immune system as a "danger signal." This recognition happens through special receptors on immune cells called Toll-like receptors (TLRs), specifically TLR2, TLR4, and TLR7.

> CPMV and IFN-gamma: Studies have shown that exposing human immune cells (peripheral blood mononuclear cells or PBMCs) to CPMV induces the secretion of IFN-gamma, a potent anti-tumor cytokine.

> Encapsulated RNA: The CPMV virus nanoparticle contains encapsulated RNA, which is one of the triggers for the immune response. The RNA activates TLR7/8, which leads to the production of Type I interferons (IFN-α and IFN-β), further boosting the immune system's anti-cancer response.

There are (differently encapsulated) RNA cancer vaccines in development.

CPMV is basically already a general purpose bioengineering platform with significant review IIUC?

How dietarily exposed to EPS3.9 polysaccharide are humans and cancer-resistant animals? Is there a one-two CPMV + EPS3.9 cancer treatment opportunity?

From https://news.ycombinator.com/item?id=44988761 :

> Can EPS3.9 cause pyroptosis cause IFN cause epitope spreading for cancer treatment?

/? Spongiibacter nanhainus CSC3.9 : https://www.google.com/search?q=Spongiibacter+nanhainus+CSC3... :

> Spongiibacter nanhainus CSC3.9 is a novel deep-sea bacterium isolated from a [deep ocean] cold seep [with blue light] that produces both a volatile organic compound (VOC) called VOC-3.9 with broad-spectrum antimicrobial activity and a sugar-based compound, exopolysaccharide (EPS3.9), which targets cancer cells by inducing programmed cell death

Could CRISPR or similar produce an alternate bacterium that's easier to brew which also produces EPS3.9 without the cold temperature and high pressure? Are there potentially other natural sources of EPS3.9 besides CSC3.9?

Endocannabinoids and the ECS Endocannabinoid System modulate and regulate immune and inflammatory responses (in non- and pre- insect invertebrates and in all vertebrates). Omega PUFAs are endocannabinoid precursors. There are also (fat-soluble) Omega polyunsaturated fatty acids in algae and in fish.

A bit of research on cancer again today: https://share.google/aimode/Qpar9RPUNy65IDt8n

Would there be advantages to CPMV + EPS3.9 + CPMVprime + mRNA for cancer therapy? https://g.co/gemini/share/9c6526d1991f