MurphyA/hacker-news huggingface dataset:
by robwwilliams | 2025-06-15 21:06:26+00:00
The explanation of “How” is not made well. Here is the crux:

“This improvement in survival reflects the impact of intensive treatment regimens. These treatments usually still involve years of intensive chemotherapy, which is often physically and mentally challenging and can cause long-term side effects.”

“Intensive treatment regimens” is awkward jargon.

What this should say is “the right dose for the individual patient given their genotype, age, and disease subtype”.

Progress over the last 2+ decades has involved state-of-the-art genotyping of key gene variants involved in handling various aspects of cancer therapeutics: drug transporters, drug metabolizing genes (P450-type), and genes that modulate excretion rates.

What also must be highlighted is MAJOR progress in remission and survival without any major changes in the actual drug armamentarium (until very recently).

Finally a shout-out to NIH programs and extramural support that made much of this possible. And to Saint Jude Children’s Research Hospital in Memphis, Tennessee, with donations received from around the world. Bravo.
by zzo38computer | 2025-06-15 21:07:08+00:00
I had implemented some computer games in DOS.

I had wanted to implement a spreadsheet, although I intended a "zoned spreadsheet", which has a zone grid (separate from the data grid), and each zone row has a number of data rows and each zone column has a number of data columns, and some properties are then properties of zone cells and others are properties of data cells. I think this would be better than most existing spreadsheet programs.

I did not know of some of the things that are mentioned there.
by motohagiography | 2025-06-15 21:07:20+00:00
recently came to appreciate the irony in proving who we are via catchpas, password complexity, and context switching 2FA is that any security method without personal irritation will get automated and broken. therefore, all security requires for us to prove the authenticity of our being by demonstrating suffering somehow- and an authentication method without evidence of suffering cannot prove we are real.

it's funny, but tracks infosec life pretty well, that we've stumbled into a proof that the necessary condition for a system to verify we are alive and are our authentic being is to offer up some minor suffering to it.
by wunderwuzzi23 | 2025-06-15 21:07:31+00:00
Yeah, improving robustness from prompt injection which such techniques will help.

One attack avenue that is surprisingly not discussed much is that the model itself can be the attacker.

In that case prompt injection is not the root cause, but a misaligned/backdoored model that might invoke tools is.

So super risky use-cases should always require human oversight, but I'm worried we are already on a path of normalization of deviance.

It's sort of the unlikely worse case scenario, but Murphys law reminds us that such an attack/accident will happen one day.
by amendegree | 2025-06-15 21:08:04+00:00
Iran’s military spending hasn’t decreased significantly since 2015. Which you would expect if your “hypothesis” had any legs. It has in fact increased. Thus again disproving your spurious claims.

Please point to these supposed experts, everything I saw from that time was that only those naive enough to believe a pack of lies claimed the nuclear deal would work, while everyone else was pointing out all the ways Iran was totally subverting it.
by riordan | 2025-06-15 21:08:20+00:00
Seriously - I find myself coming back to read this once every few years because of how riveting the piece is (oh no -just realized the pun)

Also I’ve heard wonderful things about The Great Miscalculation[0], a recently released book about the Citicorp Tower incident

[0]: https://search.worldcat.org/en/title/1458613829
by andrewstuart | 2025-06-15 21:10:16+00:00
LLMs will usher in a programming future that looks nothing like today’s programming.

Today, we are shoveling the old way into LLMs.

In the future, programming will be optimized for LLMs and not humans.

Do you understand the assembly language that the compiler writes today? Do you inspect it? Do you Analyse it and not trust it? No, you ignore it.

That’s the future.

Languages written purely for LLMs have not yet been invented but they’re coming for sure.
by rco8786 | 2025-06-15 21:10:23+00:00
Yep totally agree. And also realistically once we hit that kind of scale it was perfectly reasonably to start looking at other options as well.

It's been a while but I think we were at like 250mm MAUs when we finally decided to break up the rails monolith (and I think it was still on Rails 3 at the time, but don't quote me on that). The number of companies that ever hit that kind of scale approaches zero, and even less in the B2B space.
by MisterBastahrd | 2025-06-15 21:11:18+00:00
If he didn't want them sold, he should have destroyed them. Because even if his current heirs decide to keep them locked up, eventually someone is going to come to the realization that they don't need to work anymore if they sell a few of them, and why would you spend your life working for someone else when you could just get rid of something that only takes up space to begin with?
by xandrius | 2025-06-15 21:12:05+00:00
One could say this about absolutely any technology.

Using a hoe is making you weaker than if you just used your bare hands. Using a calculator is making your brain lose skill in doing complicated arithmetic in your head.

Most have never built a fire completely from scratch, they surely are lacking certain skills but do/should they care?

But as with everything else, you can take technology to do more, things that might be impossible for you to do without it, and that's ok.
by MangoToupe | 2025-06-15 21:12:52+00:00
Has any country ever functioned like that? The idea seems absurd. Of course you should be held legally accountable for what you say. You can see trivial examples in American culture with defamation law, laws against calling for violence, laws about when and where you're allowed to protest. Agree with it or not, we don't have a right to say what we want with no consequence. The devil as always is in the details. But people need to actually agree what sort of values we should have represented as a people to write those laws, and america has never figured out how to do that without either violence or a massive river of cash to distract us from each other.

For an instance of how bad free speech can get, look no further than the role RTLM played in the genocide of the Tutsi in 1994.
by paxys | 2025-06-15 21:13:22+00:00
I don't know why the article and everyone here is coming away with the conclusion that Bob Ross didn't want his art to be sold.

A simpler reasoning is that there wasn't any demand for his paintings while he was alive. His show ran from 1983-1994 and he died in 1995. He was reasonably popular at that time, sure, but Bob Ross as we know him only blew up in the 2010s in the internet/YouTube/streaming age.

Now there is a trove of 1,165 paintings which are no doubt valuable, but cannot all be sold because they would flood the market and decrease their own value. So Bob Ross, Inc. is cleverly keeping them under lock and key and letting the scarcity drive prices up.
by ylee | 2025-06-15 21:13:51+00:00
I have never been paid to write code, and my formal CS education is limited to AP Computer Science, and a one-credit Java class in college.

I wrote 20 years ago a backup script implementing Mike Rubel's insight <http://www.mikerubel.org/computers/rsync_snapshots/> about using `rsync` and hard links to create snapshots backups. It's basically my own version of `rsnapshot`. I have deployed it across several of my machines. Every so often I fix a bug or add a feature. Do I need to do it given `rsnapshot`'s existence? No. Is it fun to work on it? Yes.

(I've over the years restored individual files/directories often enough from the resulting backups to have reasonable confidence in the script's effectiveness, but of course one never knows for certain until the day everything gets zapped.)
by greybox | 2025-06-15 21:15:01+00:00
I'm so glad someone is taking these forward. Her videos were a god send when I started out learning this language. Besides the sometimes strange rants about text-books, her videos are top notch.

This looks like it took a lot of effort to transcribe with all her helpful graphics too.

Thank you for doing this!

R.I.P Cure Dolly
by AlotOfReading | 2025-06-15 21:16:13+00:00
This is one of those datasets that no one besides an academic with a very narrow research question is likely to find useful. It's not reflective of what we understand about the extent of historical urbanism today, it's just a synthesis from two earlier, systematically flawed datasets into a machine readable form. It misses a lot, like the entirety of ancient urbanism in North Mexico/the American southwest, Numidia, Axum, large urban centers in central Asia, etc. The authors were aware of many of these shortcomings when they published this, but didn't want to add additional shortcomings from omissions beyond what the original datasets had.
by vennom | 2025-06-15 21:16:27+00:00
I got pretty bummed when I heard the Flutter team wouldn't be releasing official support. I'm really impressed with this package so far - it seems to handle the liquid class rendering better than most others I've seen.

Love or hate the design pattern, it's pretty cool to see. Source code here: https://github.com/whynotmake-it/flutter_liquid_glass/tree/m...
by prmoustache | 2025-06-15 21:18:19+00:00
Because he was a celebrity?

I paint myself occasionally some similarly uninspired stuff, and bar 2 painting I hung in the living room and corridor, I throw them away (or rather reuse the canvas) because I don't even consider them art but rather artisanal decorative items.

2 thousand can get you much more interesting paintings. There are many talented but barely known artists anywhere in the world waiting for you. You just have to visit galleries whenever you are visiting a town.
by h2zizzle | 2025-06-15 21:18:27+00:00
On the one hand, yes, but also consider that game animation is fundamentally different from cinematic animation. It often has to be modular and loopable, but that also means that much of it can be treated like anime's "sakuga" stock footage (high quality, because it's going to be seen a lot). Cuphead was also something of a passion project, and the studio insisted on studying and replicating the older techniques to the best of their ability.

Basically, reverse engineering that process is probably a more expensive undertaking than most studios are willing to take. Look also at the Cuphead animated series, which was animated like a modern production (sadly).
by cue_the_strings | 2025-06-15 21:19:01+00:00
When I was a kid in the 90s and early 00s in Serbia, later Montenegro, I knew 2-3 kids that had leukemia at some point, and if my memory serves me well, all of them survived. One neighbor kid had it really rough (was in therapy for years, looked like hell), but still survived. Even then, the treatments were so available that surviving it was the expected outcome.

Just years before it was quite common for children to die from it - I know 2 couples who lost kids to it in the 80s and early 90s.

Another thing was that a couple of kids had congenital heart conditions. Those didn't fare that well. My classmate from elementary survived that with a pacemaker, but a neighbor suddenly died in her mid-20s, that was really sad.
by southernplaces7 | 2025-06-15 21:19:08+00:00
If your being "creative" consists of nothing more than having an AI vomit things up for you with no input on your part except for some prompts, you're not a creative. If my argument above seems repetitive, it's because i'm trying to hammer home a point that should be obvious, and is obvious to any number of people who exercise real creativity, regardless of its medium.

Also, ad hominem is fine as long as it doesn't form the main thrust of an argument.
by heraldgeezer | 2025-06-15 21:20:29+00:00
Really, its own internet system before the internet. Massive load of calls. The routing has to be correct. I never understood it before working in telecom, but phones numbers are unique... for routing, like IP-addresses. And it could never go "down". In the 80s it was all digial too (Ericsson switches) and had to be real-time.
by kjksf | 2025-06-15 21:21:31+00:00
I've listed several reasons why I decided to write and use this implementation:

- better call stacks in crash reports - smaller and faster at runtime - faster compilation because less complicated, less templated code - I understand it

So there's more to it that just that one point.

Did I loose useful attributes? Yes. There's no free lunch.

Am I going too far to achieve small, fast code that compiles quickly? Maybe I do.

My code, my rules, my joy.

But philosophically, if you ever wonder why most software today can't start up instantly and ships 100 MB of stuff to show a window: it's because most programmers don't put any thought or effort into keeping things small and fast.
by ylee | 2025-06-15 21:23:05+00:00
I have never been paid to write code, and my formal CS education is limited to AP Computer Science, and a one-credit Java class in college. But like 2OEH8eoCRo0, I can say that Red Hat Linux changed my life. Experience running Linux from kernel 1.2.13/Red Hat Linux 2.1 onward at home, and contributing small bits of code to a project or two (and RPMs to community repos), got me into a career at Wall Street after college, covering hardware and software companies (including RHAT) as an equity analyst during and after the dotcom bubble.
by sotix | 2025-06-15 21:23:34+00:00
Does the hoe operate itself?

I took a statistics course in high school where we learned how to do everything on a calculator. I was terrible and didn’t understand statistics at the end of it. My teacher gave me a gentleman’s C. I decided to retake the course in college where my teacher taught us how to calculate the formulas by hand. After learning them by hand, I applied everything on exams with my calculator. I finished the class with a 100/100, and my teacher said there was no need for me to take the final exam. It was clear I understood the concept.

What changed between the two classes? Well, I actually learned statistics rather than how to let a tool do the work for me. Once I learned the concept, then I was able to use the tool in a beneficial way.
by CobaltFire | 2025-06-15 21:24:41+00:00
My son, not I, had ALL and is in remission.

I don't know how to quantify the impact it had on him from a personality perspective, as he is severely autistic and barely speaks. He was in treatment from age 3 to 6.

For the rest of his family (parents and sibling) it had a massive impact. I already had anxiety issues (TBI while in the military flipped that switch), now I have something my doc describes as health related PTSD.
by kimixa | 2025-06-15 21:24:51+00:00
I feel there's a generation of Brits burned the wave of random telecoms companies digging up major roads for years for cable, only for the results to be pretty much useless by the time it's done as ADSL and existing POTS lines could do pretty much the same thing without any more digging.

The words "Diamond Cable" still fill me with dread to this day. They dug up half our village to then offer no service.
by rwmj | 2025-06-15 21:25:21+00:00
My physics teacher in the 1980s (sadly RIP a few years ago[1]) told me that the location of telephone exchanges was a UK state secret. The theory was that the Russians would nuke them destroying the country's ability to communicate, but as their location was a secret that outcome could be prevented. 40+ years on, I wonder if any of that was actually true?

[1] https://johnchess.blogspot.com/2019/11/david-welch-1945-2019...
by runarberg | 2025-06-15 21:26:51+00:00
2015: 10.38 Billion USD (inflation adjusted)

2023: 10.28 Billion USD (inflation adjusted)

https://data.worldbank.org/indicator/MS.MIL.XPND.CD?location...

Expert opinion:

* https://carnegieendowment.org/emissary/2025/04/iran-nuclear-...

* https://nationalinterest.org/blog/energy-world/us-iran-nucle...

Note that neither tout the success of 2015 directly (why would they, it failed after USA withdrew) but rather are proposing a new deal would build upon stuff that worked in 2015:

> In 2015, the JCPOA’s durability stemmed in part from expert-level dialogue between scientists, including US Energy Secretary Ernest Moniz and Ali Akbar Salehi, then-head of the Atomic Energy Organization of Iran. Reestablishing that kind of technical cooperation is essential to crafting a framework that can both verify compliance and contain Iran’s nuclear ambitions.
by tanewishly | 2025-06-15 21:27:37+00:00
Bob Ross was known in my country (in Europe) due to his show at the time. Not quite universally, but probably closer to a household name than any other living painter was at the time. Dunno how it was in other countries in Europe, but still. The man was relatively well known for paintings, paintings that were regarded well by the general audience (experts: dunno).

So while maybe he couldn't be selling his paintings for 1000s to the decently-off, there clearly was ample demand. If he truly wanted to make a boatload, he easily could have.

Related: the treasure trove could easily be sold 1 painting at a time. Just don't make it regular - not once a year, but sometimes 2 in 2 months, and then 5 years nothing. That really wouldn't spurs the value that much, if at all.
by dginev | 2025-06-15 21:27:40+00:00
Sure, the repository is open source (linked from the front page).

The selection did not get much thought at all, just a Rust rand shuffle over all ids performed at first page visit and then cached: https://docs.rs/rand/latest/rand/seq/trait.SliceRandom.html#...

I had all IDs already computed for the previous/next article navigation feature, so it seemed fun to reuse them.
by arp242 | 2025-06-15 21:27:52+00:00
They put him in a Mountain Dew ad: https://www.youtube.com/watch?v=q51bomzSQ_s

The Kowalskis sued to exclude Bob Ross from the company bearing his name in the final days of his life, when he was struggling with cancer.

So let me carefully suggest that Bob Ross Inc. is not as benevolently looking out to preserve the heritage and legacy of Bob Ross as you might think.
by p1anecrazy | 2025-06-15 21:28:00+00:00
I came across hobo symbol system in Richard Sproat‘s „Symbols: An Evolutionary History from the Stone Age to the Future“. In an overview of non-linguistic symbols systems he groups hobo signs with Gaunerzinken, signs used by German-speaking vagabonds. The body of research for them was more skewed towards crime as most analysis was done as part of police investigations. Would really recommend this book as a non-professional level introduction on the topic.
by naolketema | 2025-06-15 21:28:21+00:00
I’ve been working on Hook-Engine, a TypeScript-based webhook engine for Node.js, and just open-sourced it.

It’s designed for production use—focused on reliability, observability, and ease of testing. I built it to handle real-world webhook flows without needing to patch together custom logic every time.

Highlights: Supports 7+ providers out of the box (Stripe, GitHub, Shopify, etc.)

Built-in signature verification (HMAC, Ed25519, ECDSA)

Health checks, structured JSON logging, Prometheus metrics

Automatic retries, circuit breakers, and multi-tenant support

CLI for testing, simulating, and benchmarking events

Deploy-ready with Docker and Kubernetes configs If you’re building systems that rely on webhooks, I hope it’s useful.

GitHub: https://github.com/ALPHACOD3RS/hook-engine NPM: npm i hook-engine
by out-of-ideas | 2025-06-15 21:28:35+00:00
there are api monitoring tools; my goto is this: https://learn.microsoft.com/en-us/sysinternals/downloads/pro...

MS had a tool that let you set an applications "observed" system variables, like OS ect; this was back in win2000 and before now modernization of the windows compatibility stuff, new stuff sort of superseded it. i currently recollect the exe name even after inspecting a win2000 iso - edit2: apparently apcompat.exe ( lol this archive page triggered some memories: https://ia802200.us.archive.org/view_archive.php?archive=/33... )

edit: there were even api firewalls, zonealarm had one, and a number of others. i think people lost interest in locking their systems down as they seem very unpopular nowadays
by gambiting | 2025-06-15 21:29:04+00:00
Except they are not, because all of these turbines are "emergency" generators which are completely exempt from any environmental regulations, due to being designed well....for emergencies. But it looks like xAI found a loophole that says they can operate them 364 days a year and it's still legal, so no, they don't actually do any emissions control on them.
by tonymet | 2025-06-15 21:29:18+00:00
on a typical year there are 300,000 deaths due to medical error. If you tell 30% of the population to go to the hospital unnecessarily you can hit 1M excess deaths very easily.

The definition of the disease and disease mortality were nebulous. If someone goes to the hospital in panic because of a cough, they are ventilated and die -- was that from covid?
by JdeBP | 2025-06-15 21:29:55+00:00
I might have an OS/2 programming manual. But I don't need it. (-: This was not an OS/2 thing. We had to make map data structures using thread IDs. Or our language runtimes did.

Look to Windows NT rather than to OS/2 for thread-local storage. TlsAlloc() et al. were in the Win32 API right from NT 3.1, I think.
by d3r1ck | 2025-06-15 21:30:47+00:00
Hi,

* As usercvapp mentioned, I'm fetching nutrition data from USDA (https://fdc.nal.usda.gov/).

* I would say yes, USDA is the gold standard for food and nutrition data.

* Each ingredient is matched with foundational and legacy foods (not pre-packaged or branded) so if the matching is right the values are accurate.

* Final nutrition label relies on specific quantity and unit of each ingredient extracted, which you can edit to ensure the best estimation accuracy.
by hn_throwaway_99 | 2025-06-15 21:31:43+00:00
> that anyone could paint similar low/average uninspired stuff.

I hated this sentence. What is wrong with art that is actually, you know, pretty to look at. Obviously Bob Ross paintings aren't very complicated, as they're designed for amateurs to be able to follow along in the instructions. But I find many of his paintings quite beautiful, and if anything the joy in seeing how simple brush strokes can create such beautiful paintings.

Tracey Emin's "My Bed" "sculpture" sold for two and a half million pounds. So people pretending there is some high objective or moral difference between "high art" and "low/average uninspired stuff" are, frankly, full of themselves IMO.
by sorcerer-mar | 2025-06-15 21:32:19+00:00
> You can see trivial examples in American culture with defamation law, laws against calling for violence, laws about when and where you're allowed to protest.

Defamation is extremely hard to stick in the US.

You also are allowed in general to call for violence in the US. Incitement is very specific and not merely "calling for violence."

> we don't have a right to say what we want with no consequence.

Yes, in the US you absolutely are allowed to say what you want with no state-sanctioned consequence. There are extremely, extremely narrow exceptions. Way, way narrower than most people on either side of the political aisle intuit.

For an instance of how great free speech can get, look no further than the role the 1st Amendment has played in creating a highly adaptive society that, despite the internal chaos, conquers most of its challenges.