MurphyA/hacker-news huggingface dataset:
by SketchySeaBeast | 2025-06-05 21:14:36+00:00
From your chosen quote, it doesn't seem to indicate that fasting specifically changed things, but fasting being an "effective means for weight loss" was the bit that really mattered. I don't see anything to divorce the two - general weight loss and improvement to the FLI.

> Available evidence suggests that any form of caloric restriction may be beneficial and specific forms of IF should be tailored to the individual.

Also important to notice that once the liver is damaged it's not recommended to fast:

> Additionally, it is important we investigate the possible risks of fasting in patients with cirrhosis, which is currently not recommended.
by toomuchtodo | 2025-06-05 21:14:44+00:00
The drugs are the help. Nutrition is of course important (quality macros, broadly speaking, proteins, fats, fiber), but you’re not going to outrun a misfiring reward center demanding you eat when you don’t need to with “willpower” or whatever folks want to call it. There is no shame in needing pharma interventions or other medical assistance. We are imperfect, and that’s okay.
by zbentley | 2025-06-05 21:14:51+00:00
Honestly, that mixing of concerns is the biggest benefit, at least for me.

While Erlang clearly lost the popularity war, using it (well, Elixir in my case) feels like going to an alternate timeline where it wasn’t a given that a good application used separately developed tools for frontend, backend, database, cache, service discovery, load balancing, containerization, orchestration, and so on. We really could have been on a platform that incorporated all of those things into a single runtime.

The way I explain Erlang to folks is: “it’s not a competitor to Python running Django in Gunicorn; it’s a competitor for Python+Django+Gunicorn in Docker on Kubernetes on Linux, talking via a service mesh and storing data in disk-persisted Redis.” In many ways, swapping out only the top of that stack with Erlang is going to leave you worse off than you were before.

Sadly, the Erlang renaissance was years late to the boom of containerization+orchestration+distributed systems, so we’ll never know how good (or bad) things could have been. Ah well, c’est la vie.
by Theodores | 2025-06-05 21:15:00+00:00
The article isn't just poor journalism, it crossed the line into soft propaganda for the weight loss drugs.

There is a lot of money riding on these drugs, and there is a story as to how we have got here. The drug companies that are marketing these weight loss drugs switched up their game after their previous cash cow, insulin, ran out of patent protection. Sure, they have got a new fix, but they care about their shareholders, not anyone's waistline. This does not make them evil, it is just business.

Standard practice for all drugs is to get them through the regulatory hoops for one thing, in this case diabetes (2) and then go off label, to get them prescribed for weight loss and now, fatty liver disease.

All of these conditions are one an the same, metabolic syndrome. So it does make sense to have these 'off label' uses, but you have got to respect the hustle.

If the article was properly researched then it would have outlined how that lifestyle interventions are preferable to prescription drugs, and that plenty of research papers have shown that Mediterranean and whole food, plant based diets (devoid of processed foods and animal products) have had some success at reversing fatty liver disease and enabling patients to obtain a healthy BMI.

I know some people throw a temper tantrum if a banana or a chickpea is placed on their plate, but the heart of the problem is lifestyle choices. Nobody is selected by a cruel roll of the dice to get metabolic syndrome, it is a lifestyle of car dependency, processed foods and saturated fats from animal products, probably washed down with fizzy drinks and alcohol.

Your mates that took Ozempic is anecdotal. Also anecdotal, everyone I know that follows Michael Pollan's advice to eat (mostly) plants has a healthy BMI.
by switchbak | 2025-06-05 21:15:04+00:00
"when someone says", "no one draws" ... who are these people you're talking about? The folks I listen to make it very clear the kinds of platforms they're talking about, and use different terms to describe things at different levels of specificity.

Many/most folks use the term "drone" to talk about CCA's and other expensive platforms. In fact, "drone warfare" predates the common application to quadcopters, people were calling the Predator drone a drone in the early 2000's. I do agree that calling everything a drone is annoying though, and makes it hard to know what people are talking about. "AI" is having the same problem today.
by Amezarak | 2025-06-05 21:15:57+00:00
I eat enormous amounts of dairy and red meat and recently I had abdominal surgery and the doctor afterwards confirmed I was in very good shape and had no signs at all of fatty liver and very little visceral fat generally.

I eat around a pound of beef a day, a gallon of yogurt a week, and almost everything (eg oatmeal) is made with copious amounts of butter.

I think unless you know something specific about your genetics, just eat plain natural foods people have been eating for millennia and you will be perfectly fine. Basically, buy plain meat, vegetables, grains, and dairy and prepare them yourself. Don’t eat preservatives, corn syrups, or novel vegetable oils like canola. Maybe they’re fine but there’s no reason to risk it. Also do your best to make sure what you eat followed the same rule; eg my beef was grass fed and finished and was not fed skittles in a feedlot. Diet affects animal meat as well, just as it does us.
by Qem | 2025-06-05 21:16:26+00:00
I wonder, given the instances of common diseases that were discovered/strongly suspected recently to have a microbial component (eg. ulcers + heliobacter pylori, Guillain–Barré + cytomegalovirus, Alzheimer + HSV, Several cancers in men and women + HPV), what are the odds we'll eventually discover fatty liver disease is a symptom or is triggered by "hepatitis X" or something like that?
by mikeshi42 | 2025-06-05 21:18:30+00:00
First off, always really excited to hear from our production users - glad to hear you're getting good value out of the platform!

HyperDX isn't being deprecated, you can probably see on the marketing page it's still really prominently featured as an integral part of the stack - so nothing changing there.

We do of course want to get users onto HyperDX v2 and the overall ClickStack pattern. This doesn't mean HyperDX is going away by any means - just that HyperDX is focused a lot more on the end-user experience, and we get to leverage the flexibility, learnings and performance of a more exposed ClickHouse-powered core which is the intent of ClickStack. On the engineering side, we're working on making sure it's a smooth path for both open source and cloud.

side note: weird I thought I replied to this one already but I've been dealing with spotty wifi today :)
by voidfunc | 2025-06-05 21:18:35+00:00
Your math is off, here's my schedule:

Sunday 10pm - Tuesday 10am - No food.

Tuesday 10am - Tuesday 10pm = 1500

Tuesday 10pm - Thursday 10am = No food.

Thursday 10am - Thursday 10pm = 1500

Thursday 10pm - Saturday 10am = No food.

Saturday 10am - Sunday 10pm = 3000 (Sat 1500cal, Sun 1500cal)

6000cal.

Though I agree there probably is some fuzziness in those 1500 days that I'm not properly accounting for.
by xandrius | 2025-06-05 21:19:02+00:00
Normally to make a new smallish feature it costs me about $0.40.

The core suggestion is to point specifically at the files you want it to read and use as a reference, otherwise it might go read some huge file for no reason. Also the tokens used depend on the size of the project.

Generally, if I'm doing something I can box, I'd use chatgpt and copy it in myself. If I want something matching the style, I'd use a guided Roo Code.
by ben_w | 2025-06-05 21:19:38+00:00
Given Trump didn't care about protestors chanting to hang his own vice president, skin colour definitely won't save Musk: https://www.politico.com/news/2022/05/25/trump-expressed-sup...

Like you, I'm not so sure the money won't. But at the same time, I think about half Musk's money is an absurd overpricing of Tesla shares, and most of the rest is SpaceX, only minimal resaleable stuff in xAI and x.com, even less in TBC and Neuralink — if there was suddenly no FAA approval for flights, no help selling Starlink to everyone (worldwide), SpaceX just dies.
by sfRattan | 2025-06-05 21:19:41+00:00
Apologies. I misread. Yeah, it sucks that Google Pay doesn't work on GrapheneOS.

Though Google Pay is also probably the least private of the major tech-company payment platforms (the others being Apple Pay, Samsung Pay, and Garmin Pay). It is, I think, the only one that actually requires an open network connection on the phone to work. The others all generate one-time codes that get sent through the payment machine's network for verification by Apple/Samsung/Garmin on the backend (i.e. you can tap an Apple Watch to pay with all its radios off, but you can't do that with Google Pay).

From what I gather, Garmin Pay can work with GrapheneOS if you have one of their smartwatches. And Privacy.com works, but not with tap-to-pay.
by WWLink | 2025-06-05 21:20:05+00:00
That problem plagues every OS. Fortunately, my 14 year old canon networked printer/scanner/fax works in fedora 42 without any configuration at all. As long as it sees it on the network. Scans too! I was surprised about the scanning lol.

The brother wifi laser printer I have works on everything without any installation at all. Windows, mac, linux, my phones.
by bsder | 2025-06-05 21:20:14+00:00
> “They are rich and naive”.

This is blaming the victim, and I'm not having it.

The problem has been that BankCorp are all forcing us into online pathways because it's cheaper for BankCorp. Of course, they don't put good security on the pathways because that would dramatically increase the customer support cost for BankCorp. Getting scammed is "just sucks to be you" because that costs LittlePlebian.

The "solution" is that liability for these kinds of scams need to be on BankCorp, period. LittlePlebian simply cannot be expected to protect themselves from every professional scammer in the universe beyond very basic measures. Bitcoin people regularly get scammed and they are supposedly more "sophisticated" than the average bear. Nobody less sophisticated stands a chance against the professionals.
by pombreda | 2025-06-05 21:20:40+00:00
Yeah, the CPE idea of a vendor for an open source package does not compute too well!

FWIW, PURL came about as I could NOT put my mind around CPEs when I was scanning for package and deps with scancode and could not find any easy way to go from that to looking up a vulnerability/CVE in the NVD, as it was all guesswork and manual.

So we started instead to put the vuln data in our own db, keyed by something that would be easy to relate from the scans. This eventually became PURL

This is all tracked in these places: - The original issue: https://github.com/aboutcode-org/scancode-toolkit/issues/805 - The initial pull request with many comments: https://github.com/package-url/purl-spec/pull/1
by jstummbillig | 2025-06-05 21:20:41+00:00
There is some serious confusion about the strength of OpenAIs position.

"chatgpt" is a verb. People have no idea what claude or gemini are, and they will not be interested in it, unless something absolutely fantastic happens. Being a little better will do absolutely nothing to convince normal people to change product (the little moat that ChatGPT has simply by virtue of chat history is probably enough from a convenience standpoint, add memories and no super obvious path to export/import either and you are done here).

All that OpenAI would have to do, to easily be worth their evaluation eventually, is to optimize and not become offensively bad to their, what, 500 million active users. And, if we assume the current paradigm that everyone is working with is here to stay, why would they? Instead of leading (as they have done so far, for the most part) they can at any point simply do what others have resorted to successfully and copy with a slight delay. People won't care.
Ask HN: Validating a Tool to Help Founders Stay Focused and Build What Matters
by mmarvramm | 2025-06-05 21:21:10+00:00
I’m currently validating a problem I’ve seen often (and experienced myself): early-stage founders wasting time building in the wrong direction.

Inspired by the SaaS Playbook, LeanStack, YC School, and other frameworks, I’m exploring an AI-powered tool that guides founders through idea validation and early-stage decision-making—using the best principles, made actionable.

The idea is a self-guided product that combines structured startup advice with AI models like GPT-4 or Claude Opus to act as a real-time co-pilot for early builders.

I’d love to hear your thoughts. Have you felt this pain? Would something like this be useful?

And if you’re open to a quick feedback chat, let me know—especially if you’re a solo founder or early-stage builder (but anyone’s welcome).

Thanks! ~Mihai
by bokohut | 2025-06-05 21:21:16+00:00
Your sixth sense is accurate @TimTheTinker however it goes beyond just home for your awareness. This opportunity I see is below Oxide and targets any SMB that has data ownership and security for their business over time as an objective(+ many more). I am currently engaged in discussions with several niche businesses about building modular and extensible software specific to their industry needs of which the current industry software, written by non industry experts, doesn't support. Many business owners which contact me are disgusted in being fee'd to death so the opportunity to cut out those middlemen is massive and growing. Maybe this is your sixth sense tingle?
by kentonv | 2025-06-05 21:22:37+00:00
Yes, the ethical debate is fair and worth having, and I don't think someone necessarily has to try it to be able to debate the ethics. I obviously don't quite agree with his opinions here but I respect them.

(Though I would say, before I really tried it, I had believed that AI does a lot more "plagiarism" -- lifting of entire passages or snippets. Actually using it has made clearer to me that it really is more like someone who has learned by reading, and then applies those learnings, at least most of the time.)

I just don't like it when people argue that it doesn't work or doesn't do what they want without having actually tried it... There's too much echo chamber of people who don't want AI to work, and so convince each other that it doesn't, and repeat each other's arguments, all without ever taking a step outside their comfort zones. (Again... this was me, 6 months ago.)
by _wire_ | 2025-06-05 21:24:09+00:00
Consider that strategic nuclear weapons are useless for offensive tactics; they only function as a deterrent. Yet Putin's is still practicing Cold War diplomacy, like nukes are an ace in the hole. By hitting those bombers, the old diplomatic hole card of nuclear primacy is revealed as a strategic deuce. Saavy.

Putin's long game is played out. His solitary, isolated posture as a lone but rational actor only works against him from here on out.

If Russian is in fact democratic in the sense of representation with any care for what its people think, any attempt to re-visit Stalin era mobilization and national sacrifice for the sake of eastern Ukraine is absurd, while if Putin tyrannically commits the people of Russia to the cause, the fragile artifice of Russian state progress in governance and human rights collapses to dust like the leadership of Gaza.

Becoming irrational serves no purpose, because Russian taking on the world at scale is like as if Italy decided to be a world belligerent. Ridiculous, with no upside.

It would be a funny turn if, in the long run, western Russia cedes to Ukraine after all those tribes that sought peace and prosperity in the arms of the ghost of the Supreme Soviet wake up to Putin's belligerence headed in the completely opposite direction to their security towards some weird Soviet state appropriation of U.S. 1950s Ozzie & Harriet purity values.
by genewitch | 2025-06-05 21:24:10+00:00
> only [...] 7TB

Currently that would probably cost ~$500 per car to implement based on retail pricing of 8TB SSDs. It would need to be updated constantly, too, with road closures, potholes, missing signage, construction. With an external GPS unit like a tomtom, they had radio receivers in the power cord that tuned to traffic frequencies, if available, and could route you around closures, construction, and the like, so you need a nationwide network to handle this. Cellphone won't cut it. Starlink might, but regardless, you need to add that radio and accoutrements to the BOM for each car.

and i'm not talking about the processing of the dataset that gets put onto the 8TB SSD in the car; i am talking about the processing of the data on the 8TB SSD on the car while at speed.

furthermore, i am fairly certain that it would take, on average, more than 1.6MB per mile to describe the road, road condition, hazards, etc. a shapefile of all roads in the US - that which gets one closer to knowing where the lanes are, how wide the shoulders are, etc is 616MB. and it's incomplete - i put in two roads near me with fairly unique names and neither are in the dataset. So your self driving car using these GIS datasets won't know those roads.

I had an idea to put an atomicpi in my car, with two cameras. it has a bosch 9-dof sensor on the board, coupled with the cameras you can map road surface perturbations, hazards, and the like, which i believe will be much more than 1KB per meter, especially as you need "base" conditions and updates and current conditions (reported by the cars in front of you, ideally). the csv GIS dataset looks like this:

>OBJECTID,ID,DIR,LENGTH,LINKID,COUNTRY,JURISCODE,JURISNAME,ROADNUM,ROADNAME,ADMIN,SURFACE,LANES,SPEEDLIM,CLASS,NHS,BORDER,Shape__Length

> 568143,964990,0,0.07,02_36250355,2,02_39,Ohio,S161,DUBLIN GRANVILLE RD,State,Paved,4,88,3,7,0,0.000759951397761616

and i ran, for example `awk -F, '/PACIFIC COAST/ {sum += $4} END {print sum}' NTAD*.csv` and it spat out 79.04, which i think is a bit shorter than reality. Looks like the dataset i pulled is only "major roads" as well - but that doesn't explain 79.04 as the sum of lengths of all rows with "PACIFIC COAST" in them. It does show the total length of interstate 10 is 3986.55, which is roughly double what the actual length is (2460mi), so perhaps i'm just not understanding this dataset.

Anyhow 600+ MB for just that sort of information (plus shapes) for only a really quite small subset of roads in the US.

anyhow my thoughts are scattered, this input box is too small, and i'm not really arguing. Maybe it is possible, but it will raise the price thousands of dollars per auto, you need infrastructure (starlink will work) to update the cars, and so on. I'm prepared to admit i am wrong, but your comment didn't move the needle for me.

also, just to be fun, which self driving car could manage this entire drive? https://www.youtube.com/watch?v=sNqFN7KeOYE
by fc417fc802 | 2025-06-05 21:24:14+00:00
Repeatedly making the same comment all over the local tree is childish and effectively spamming.

To your observation, it's certainly relevant to the situation at hand but has little to do with your original supposition. A US court can order any company that operates in the US to do anything within the bounds of US law, in the same way that an EU court can do the converse. Such an order might well make it impossible to legally do business in one or the other jurisdiction.

If OpenAI Ireland is a subsidiary it will be interesting to see to what extent the court order applies (or doesn't apply) to it. I wonder if it actually operates servers locally or if it's just a frontend that sends all your queries over to a US based backend.

People elsewhere in this comment section observed that the GDPR has a blanket carve out for things that are legally required. Seeing as compliance with a court order is legally required there is likely no issue regardless.
by cratermoon | 2025-06-05 21:24:37+00:00
This has been going on in Texas and some other border states for nearly a century. Business interests, formerly agriculture but more recently including the hospitality industry, do not want to be on the hook for controlling immigration. They are happy to hire undocumented workers, pay them less than minimum wage and ignore labor laws.

They want cheap labor, and only give lip service to support for border control.
by dlivingston | 2025-06-05 21:25:47+00:00
To 1) and 2), assuming a digital consciousness capable of self-awareness and introspection, I think the answer is clearly 'no'.

But:

> it would be fair to say that the more advanced the field becomes, the less difference there is between the artificial brain and a real brain.

I don't think it would be fair to say this. LLMs are certainly not worthy of ethical considerations. Consciousness needs to be demonstratable. Even if the synaptic structure of the digital vs. human brain approaches 1:1 similarity, the program running on it does not deserve ethical consideration unless and until consciousness can be demonstrated as an emergent property.
by KaiserPro | 2025-06-05 21:26:03+00:00
> We don't even know if Times uses AI to get information from other sources either

which is irrelevant at this stage. Its a legal principle that both sides can fairly discover evidence. As finding out how much openAI has infringed copyright is pretty critical to the case, they need to find out.

After all, if its only once or twice, thats a couple of dollars, if its millions of times, that hundreds of millions
by pombreda | 2025-06-05 21:27:08+00:00
Yeah, I added generic as an escape hatch, but this should be only used by exception, e.g., a crutch. An abused crutch.

Eventually, let's fix this first for C/C++:

https://github.com/aboutcode-org/www.aboutcode.org/issues/30

And based on that approach we can either: 1. create new, sensible types as needed 2. and/or maintain a last resort open registry of generic types at least so we get some sanity in the process.
by mikeshi42 | 2025-06-05 21:27:16+00:00
Wow this is an incredible throwback! Can't believe your memory is this good. It's quite funny and I totally agree - I met the Gradio founders in an accelerator (when they were just getting started) after we shut down ModelDepot - and they of course ended up getting acquired into Hugging Face. It's funny how things end up sometimes :)
by joshvm | 2025-06-05 21:28:00+00:00
An important caveat here is yes, for coding. Apps are fine for coming up with one-liners, or doing other research. I haven't found the quality of IDE based code to be significantly better than what ChatGPT would suggest, but it's very useful to ask questions when the model has access to both the code and can prompt you to run tests which rely on local data (or even attached hardware). I really don't trust YOLO mode so I manually approve terminal calls.

My impression (with Cursor) is that you need to practice some sort of LLM-first design to get the best out of it. Either vibe code your way from the start, or be brutal about limiting what changes the agent can make without your approval. It does force you to be very atomic about your requests, which isn't a bad thing, but writing a robust spec for the prompt is often slower than writing the code by hand and asking for a refactor. As soon as kipple, for lack of a better word, sneaks into the code, it's a reinforcing signal to the agent that it can add more.

It's definitely worth paying the $20 and playing with a few different clients. The rabbit hole is pretty deep and there's still a ton of prompt engineering suggestions from the community. It encourages a lot of creative guardrails, like using pre-commit to provide negative feedback when the model does something silly like try to write a 200 word commit message. I haven't tried JetBrains' agent yet (Junie), but that seems like it would be a good one to explore as well since it presumably integrates directly with the tooling.