by nick__m | 2025-06-30 12:39:20+00:00
how do you know which is better?

Well you try the generic first, if it's does what it says on the tin, you continue the generic! Antibiotics, pain killer, antidepressants are usually not problematic.

Hopefully, the doctor will account for that when prescribin...

I never saw a doctor or pharmacist do that. Probably because you cannot predict the difference in a specific individual.

is there a difference between generics of the same drug ?

Sometimes the generic are better and yes there is a variation between manufacturers, when the pharmacy change my clonazepam supplier, I feel it. Sometimes I feel drugged out, sometime I am sleepless, but it take a few nights and then I feel the same. When that happen, I check the letter before clonazepam on bottle and systematically they changed, ex: apo-clonazepam to pms-clonazepam (the first three letters indicate the manufacturers, and I couldn't tell you which is better, just that there is a subtle difference when you switch) .

For stuff like that works on the hormonal system the difference between them is more pronounced. Like the femara, an aromatase inhibitors the block estrogen production, the brand name was significantly better for my wife but reading MBC survivors forums it's not the case for everyone. And reading those forums, it's a problem in place like the UK where the only things available is the brand NHS choosed for you.

How much is too much ?

Now about how much is too much, well it's an hard question. It depends mostly on the alternative available, there are a lot of asthma drugs so switching from generic ventolin to something else like xopenex is easy so it limits the pricing power of the original manufacturer. Thing like anticancer with a specific mechanism where no direct alternative exists, the price is significantly higher, something like 300$ a month instead of 60-80$. But for my insurance it's relatively nothing compared to the Kisquali that cost 5700$/month. They have to reauthorized it every 6 months (it's a bureaucratic formality but they don't want to pay for it if the cancer has reappear because it's useless to continue the treatment)

Note that I have something my pharmacist call a gold-plated drugs insurance. If we were only covered by Québec's public regime, my wife would probably be dead by now as they still do not reimburse Kisquali, it's suppose to change soon but I am not that informed on that because of my gold-plated insurance. (which is fucking stupid because the alternative was weekly in hospital chemotherapy that cost a lot more than 5700 a month, but then people with that treatment doesn't usually live that long so cynically it probably cost less to the system that way even)

Edit:

Why do I know that

A friend of my parents is a pharmacist and I used to ask him a lot's of questions when I was a child. Two of my female cousin (cousines in French) are pharmacists and I ask them questions on every new year day since at least the last 25 years. One practice in a drugstore, the other negotiate with the federal government for a big company that I won't name. Let's says they have a quite complementary vantage point. And I had quite the motivation to ramps up my knowledge of oncology to be the best advocate I can be for my wife.