MurphyA/hacker-news huggingface dataset:
by gwerbret | 2025-05-18 04:30:41+00:00
You should have read the paper (or at least the abstract) first, as they used macaque and human organoid models, too. :) But yes, the overall effects of the region of DNA in question (an enhancer) are fairly small.

The preprint is available here: https://www.biorxiv.org/content/10.1101/2024.04.10.588953v1....
by ActorNightly | 2025-05-18 04:31:21+00:00
This is really weird take.

If you were to just erase private sector debt, not much happens on a socio-economic scale. If a company is owed money, but at the same time owes people money, the debt on either side is cancelled out.

With government being the actual source of money, if it owes a lot of money, it has to "print" it, which is exactly how you historically get inflation, which then causes rising prices. This literally happened during Covid.

Lets also not pretend that the current administration actually understands anything about economy either.
by _blk | 2025-05-18 04:32:48+00:00
True but that lies in the nature of choices people make. Apart from mortgage (or in general credit on appreciable assets) I would not recommend the on-credit lifestyle that is ad-suggested as the American Dream™ (that's different for businesses, I'm not against credits in general). As an individual carry insurance, pay the year ahead. Yes it hurts, but not as much as that unexpected 500$ expense... The boot theory works pretty well with credit though ;)
by notpushkin | 2025-05-18 04:33:08+00:00
This is neat. I’ve been thinking about doing something like this on my Quest 3, but it’s a fair bit bulkier than this setup. One upside is, you already get an Android and can setup pretty much anything you might want! (I’ve sideloaded F-Droid on mine, going to see if Termux works.)

Re: Bluetooth keyboard – you can get a Thinkpad keyboard as a Bluetooth one. It’s slimmer that the usual bottom half, so it’s much more portable. But it’s not folding, of course.
by WarOnPrivacy | 2025-05-18 04:33:23+00:00
This is a shift away from informal family-based responsibility for raising children, where parents followed their intuition, ...

Informal family-based responsibility was a byproduct of extended families - back when extended families were common.

to a more child-centred, expert-informed approach,

My wife and I were fully on our own for our first child. With no extended family to draw on, we got knowledge wherever we could.

where parents pour in more time, emotion and financial investment to ensure the success of their children for which they feel personally responsible.

Because parenting went from a few hours a week with extended family support to 24/7 adulting w/ no support.

When there is no life beyond your children, it turns out that rat-racing them toward a bleak future is the best of the bad options.
by zahlman | 2025-05-18 04:34:52+00:00
>I've had my posts edited to remove phrases like "thanks for any advice which you can provide"

Yes. Doing this makes your post better, because it means everyone who reads it later saves time. Your post is not there to talk to people. Your question is there to ask a question. Your answer is there to answer the question.

This is explicit policy:

https://meta.stackexchange.com/questions/2950

https://meta.stackexchange.com/questions/131009

https://meta.stackexchange.com/questions/403176

https://meta.stackoverflow.com/questions/328379

https://meta.stackexchange.com/help/behavior ("Do not use signature, taglines, greetings, thanks, or other chitchat.")

And it follows directly from it not being a discussion forum (https://meta.stackexchange.com/questions/92107).

> Maybe you don't think eliminating gratitude from basic communications qualifies as "dehumanizing"

What you miss is that it is not communication between the person who asks and the person who answers. It is publication of a question and answer so that everyone can benefit.

When you see someone say "thanks for any advice which you can provide" directly to someone else, does that feel welcoming to you? It doesn't to me. It feels like suddenly I'm unintentionally eavesdropping on some conversation, and that I'm not supposed to be there. But I only came to learn (or teach) something.

> BTW - to the guy who called me a "troll". If you can't disagree with a fellow of your species, without branding them a troll, you've just made my point. Thank you

You appear to be making multiple throwaway accounts rather than risking your HN reputation. From the guidelines:

> Throwaway accounts are ok for sensitive information, but please don't create accounts routinely. HN is a community—users should have an identity that others can relate to.
by alephnerd | 2025-05-18 04:34:56+00:00
There will be bipartisan support for this (only 164 Ds voted against repeal in the house) - as long as Michigan, Pennsylvania, and Illinois matter, California's EV mandate will be undermined.

Neither party dares alienate the UAW or Teamsters, and thousands of automotive employees.

HN needs to reconcile whether they support unions or whether they support EVs. It's a one or the other decision at this point in the US.

Amongst the younger (Gen Z/Gen Alpha) generations, the choice is unions due to idealism (despite havint positive sentiment for EVs). Amongst high earning members of Gen X (which I think seems to represent HN), the choice appears to be EVs.
There Won't Be Spam Ads in the Future – Thanks to AI
by mrkrieg | 2025-05-18 04:35:57+00:00
AI is changing internet marketing, and it’s going to kill spam ads completely.

Let’s define spam ads: they’re the ads you didn’t ask for and don’t care about, but they still show up in your feed.

People are tired of seeing irrelevant ads. The old playbook—broad targeting, generic messages—doesn’t work anymore. To get someone’s attention today, you need to say something they actually care about. That means showing relevant messages to the right people, across the right channels.

The next logical step? Personalized marketing for everyone. Data providers are already gathering more intent data, and software will use that to generate ads and messages tailored to each person. Not just by audience segment—by individual.

This is already starting. Smarter companies are doing it now. The rest will catch up once they realize their marketing is falling flat. The answer will be obvious: more personalization.

And when that happens, even people who never buy from ads will start clicking, booking calls, and signing up—because the message will feel like it was made for them.
by fragmede | 2025-05-18 04:36:00+00:00
technically yes, at the lowest levels (polled interrupts anybody) but there's a material difference (or not, as this blog argues) depending on how they're processed. At one end of the spectrum you have bank records being reconciled at the end of the day. At the other extreme, reading individual chunks of video data off disk, not saving it, and chucking it into the Internet via udp as fast as the client can handle, but could be dropped on the floor as necessary; that doesn't really require the same kind of assurances as a day's worth of bank records.
by vunderba | 2025-05-18 04:36:19+00:00
I'm not sure stereotype is the correct word here. But even setting that aside, a thesaurus being a referential work containing words grouped by similarity is the CONVENTIONAL definition.

Everyone of my friends and family had one growing up. It wasn't completely uncommon as a young child to glaze your eyes "beautiful mind style" to suss out repetitious or excessive duplicate word usage in your hastily prepared 5-paragraph MLA format essay and then run it through the nearest Merriam-Webster thesaurus.

https://youtu.be/XAD13c3UkS0?t=49
by rixed | 2025-05-18 04:36:41+00:00
Maybe it's not worse, maybe it's just as bad, who knows?

I'd try to get my kids away from TV or comics just as hard as I tried to get my kids away from their phone.

There are of course real and worthwhile culture artifacts on any media, TikTok included, but we are talking about addiction here.

Our generation would have been so much better off without tv addiction!

(Comics? Yes, they have been well known vectors of propaganda for one, and favor in general an idiotically simple manichean worldview, and therefore an adult explaining to a kid why they are potentially harmful was also in order, no?)
by starchild3001 | 2025-05-18 04:37:16+00:00
Guys, we have predictable problems -- namely deficit. And "unpredictable" problems (such as covid and the great financial crisis). So I think US cannot even control the predictable problems that are within our control. What do you think will happen when the next unforseen crisis hits? Sadly, the government's main responsibility is to minimize the likelihood and cost of so-called "unpredictable" problems, yet through the actions of DOGE and similar regulation cutting zeal we're only increasing their likelihood and making the outcomes worse. Moody's is doing us a favor by calling our debt A- (or whatever), it's in fact junk at this point. We're one crisis away from complete bankruptcy, which is bound to happen thanks to reckless governance.

PS: See how Clinton/Bush Jr's deregulatory policies were a major contributor to the great financial crisis. See how Trump took over a pandemic playbook and office from Obama, only to disband it upon arrival. If the federal government won't even try to protect us from systemic risk, who will?
by mitthrowaway2 | 2025-05-18 04:37:56+00:00
That's one possibility, but it depends a lot on where the money gets injected and where the inflation happens. If it balloons real estate prices before wages catch up, you don't necessarily get that growth of investment into productive areas. Instead it gets more expensive and riskier to start a business, with higher rent payments, and meanwhile a lot of asset-owners retire on their newfound wealth. It gets harder to convince lenders and investers to put money into real production when speculating on land and collecting rents starts getting such good consistent returns.
by riffraff | 2025-05-18 04:41:03+00:00
Google has as much data on me as anyone is ever going to have.

At a minimum, it knows I'm middle aged and have a family, and where I live.

And yet, this morning it adviced me to go to a youth-hostel-with-nightclub in my own city (via Google assistant or whatever the thing in android is called).

I can't imagine this is due to lack analytical/focusing capabilities that will be solved by AI, it's just that the interest of ad providers and ad buyers is clearly not aligned.
by landl0rd | 2025-05-18 04:41:26+00:00
Block grants are bad.

I would prefer non-corporate tax cuts focusing on the middle class. This would also help us balance the federal budget.

I like national parks. They are one of the few things I don't mind paying taxes for. Most of the federal budget does not go to national parks.

I also live in a state that has really good state parks. Well-run, widely available, well-maintained. Hopefully we can have states help pick up the slack if there are challenges with the NPS.

You can't lump NHS in with those. I do not like public health care.

I did not put "woke" in there. I don't like the "wrapper" language. I do like some of the content.

I do not think trump in office is a good thing. I just think harris is a bad thing. Since roosevelt we have been stuck on a leftward ratchet. Liberals take office and change things. Conservatives take power and fail to reverse them.

Trump is not much of a conservative. I do think he can at least promote some reversal of the social parts. I don't care much about the social parts. But I do hope that sets a precedent for someone to reverse the practical economic parts.
by Spooky23 | 2025-05-18 04:44:06+00:00
Very few people make a lot of money, it those who do make a shockingly large amount of it.

There’s two drivers to the actual problem here… one is that wage growth slowed a lot since wage indexing and the yield on those taxes is lower in real terms. People who are making more make a lot more, and frankly that’s a well that needs to be tapped.

The other is less popular… but we’re in wind down of nearly 25 years of conflict. The events of 9/11 were engineered to and succeeded in created the same type of economic attrition the US ultimately inflicted on the Soviets.

We’re at a tipping point… our social insurance is approaching entirely avoidable cash flow insolvency. 25 years of war means that the military is worn out and needs trillions of investment to maintain parity. Ignoring the problems our strategies created brought us with a reactionary buffoon destroying the government and a fairly dim decade ahead.
by Thorrez | 2025-05-18 04:44:40+00:00
Maybe I misunderstood mixologist's point. I thought mixologist's point was that there's a logical inconsistency if someone wants states to regulate one issue, but not another issue.

You seem to be fine with allowing states to regulate AI, but not abortion. So either you disagree with mixologist, or I misunderstood mixologist. If mixologist wasn't making that point, then my previous comment doesn't make sense.

>GOP does hide behind states rights when it suits them.

It's an interesting situation. Prior to 2024, the GOP's policy was that abortion should be banned at the federal level. Trump disagreed with that, and in 2024, Trump convinced the GOP to change policy, and defer it to the states[1].

AIUI, the previous policy was based on the idea that abortion is morally wrong due to killing a person, and thus should be banned. I think the new policy is based on the idea that abortion is a moral uncertainty: the GOP doesn't know whether the fetus is a person or not, so it's unclear whether abortion is morally wrong or not, and because it's unclear, there shouldn't be a federal decision one way or the other on it, it should be deferred to the states. You could call that "hiding behind states rights", or you could call it "deferring unclear issues to the local level instead of making sweeping laws on unclear issues".

AIUI, the GOP's policy on AI is different. The GOP doesn't think AI has the same moral uncertainty as abortion does. Instead, the GOP views AI under an economic lens, not a moral lens. And under an economic lens, consistent laws across the states help economically.

[1] https://apnews.com/article/republicans-abortion-party-platfo...
by alephnerd | 2025-05-18 04:44:53+00:00
> We are going to have to transition away from ICE vehicles and we should do it asap

How do you do so without making the party that passes such legislation politically toxic for a generation? Heck, 49 Dems broke ranks and voted in favor of repealing California's waiver in the House.

Plug-in Hybrids and EVs require significantly less parts and have fairly automated manufacturing processes, so thousands of voters will lose jobs.

This is why you see the UAW and Teamsters leadership back the incumbent admin.
by jebarker | 2025-05-18 04:44:59+00:00
I don't know the answer to the question in this case, but this quote from [1] has been stuck in my mind for a while and feels relevant:

"I wish my high school biology teacher had asked the class how an embryo could possibly differentiate—and then paused to let us really think about it. The whole subject is in the answer to that question. A chemical gradient in the embryonic fluid is enough of a signal to slightly alter the gene expression program of some cells, not others; now the embryo knows “up” from “down”; cells at one end begin producing different proteins than cells at the other, and these, in turn, release more refined chemical signals; ...; soon, you have brain cells and foot cells."

[1] https://jsomers.net/i-should-have-loved-biology/
by MichaelRo | 2025-05-18 04:46:03+00:00
As a "senior" (expert) software developer you got a slight edge over a junior as long as you work in the same domain of expertise. As soon as you change project, you're at loss.

General intelligence helps but can't make up for domain-specific expertise. Example: move from accounting software to map navigation software. Clueless. Move from map navigation software to financial software. Within financial software move from quantitative pricing to exchange interfacing. Clueless.

Sure, you mostly get away with it but inevitably problems will arise that you have no idea what's causing them or even that they are a problem, so you spend days and weeks chasing what the expert figures out in minutes.

That's why I prefer to keep the domain when changing jobs because it adds up to being just a software developer.
by DavidPiper | 2025-05-18 04:48:01+00:00
Hmm I take your logical point. I think I disagree with the premises though.

> the kids on america can relate to kids that live on middle east and asia ... if this not shared cultural experience, then idk what else is

This sounds like parasocial connection standing in for shared cultural experience to me, but I don't really know because I'm quite distant from that kind of connection anyway.
by safety1st | 2025-05-18 04:49:30+00:00
I mean, in the period of history from the 1980s to now, in contrast to other periods, wealth disparity increased as a direct result of laws being changed, policies being amended, and which regulations the government chose to enforce or not enforce.

It's hard for me to look at the idea of "law, policy and regulation should now move the needle in the other direction" and see that as grossly unjust. We can debate whether social security is the right place to do it, but it seems like one of the top options to me, considering the huge wave of people who are going to be jobless, old, poor and alone, and therefore vulnerable, as the Millennials age.
by ActorNightly | 2025-05-18 04:50:16+00:00
Its a catch 22.

If the government stops spending money on programs, it looks bad.

If the government raises taxes, it looks bad.

Essentially people don't understand this, which is why grifters like Trump got elected who promise the impossible, make the economy seem good for 4 years then once shit starts going down the Dems win and have to deal with the outcome, which then they get shit for not being able to fix.
by mousomashakel | 2025-05-18 04:52:13+00:00
Thanks! That’s a great combo — manifold-sql + duckdb gives you strong typing with powerful SQL under the hood. Fahmatrix is aiming to complement that approach for cases where you want quick, native Java code without SQL — e.g., when building data flows or custom logic inline. Would love to hear if you’ve hit any pain points that a Java-native approach could help with.
by AtlasBarfed | 2025-05-18 04:52:35+00:00
Before reading article: I would like to know if this architecture will help Linux close to Apple architecture efficiencies....

After reading article: I suddenly realize that CPUs will probably no longer pursue making "traditional computing" any faster/efficient. Instead, everything will be focused on AI processing. There are absolutely no market/hype forces that will prompt the investment in "traditional" computing optimization anymore.

I mean, yeah, there's probably three years of planning and execution inertia, but any push to close the gap with Apple by ARM / AMD / Intel is probably dead, and Apple will probably stop innovating the M series.
by anenefan | 2025-05-18 04:53:12+00:00
Once the lower service (enshitification) was accepted as the norm, one could guess the higher costs to extract data from various sites these last few years, it's not that worthwhile for newcomers to spend up big without being able to offer up anything much better than what the main search engine google can offer, given a good percentage of searches are easy searches where the first page of results is probably going to satisfy the user query.
by Aurornis | 2025-05-18 04:55:16+00:00
> Because the government owns the currency it's debts are denominated in. There is zero risk the government couldn't pay it's dollar debts if there is still a US government.

> The deficit hawks don't understand how money works.

I’m afraid it’s you who doesn’t understand how national debt works. The US government doesn’t have infinite leverage to do whatever it wants with its currency with no consequences. We have to sell our debt on the public market. If we start acting like we’re going to pull currency tricks as the way to fight the debt, the interest rate we have to pay on the debt goes up quickly.

As it goes up, we have to pay more every year to service the interest on that debt. If we’re in a situation of high budget deficits the only way to service that additional interest charge is by issuing more debt, which turns into a debt spiral.

Waving it all away as a non-issue is a severe misunderstanding of the threat.
by paulddraper | 2025-05-18 04:56:31+00:00
The `using` proposal is so bad. [1]

There is exactly zero reason to introduce a new variable binding for explicit resource management.

And now it doesn't support destructuring, etc.

It should have been

using (const a = resource()) { }

Similar to for-of.

[1] https://github.com/tc39/proposal-explicit-resource-managemen...

[2] https://github.com/tc39/proposal-explicit-resource-managemen...
by dataflow | 2025-05-18 04:56:43+00:00
This is a referendum that changes the fundamental rules of the game, not a pizza order. The onus isn't on the population to waste their time vetoing your bad or mediocre ideas, it's on you to come up with good ideas. And disgusting your constituents enough that they abstain entirely should very much not be a viable strategy. If you want to change the constitution, you gotta convince people that you're doing something good, including those who are hard to convince. That's literally the entire point. If you're not managing that, clearly your change isn't good enough to make.

Anyway, I wasn't even trying to argue in favor of this position, or against it. I was merely replying to the parent comment that Brexit did not meet the threshold that their parent comment had suggested.
by klardotsh | 2025-05-18 04:56:54+00:00
That described Dutch system also sounds relatively easy compared to the US model, which requires 2/3 votes in each chamber of Congress (meaning the people-based one and the land-based one), *then* 3/4 of the states (so another land-based check) have to ratify it.

Functionally this means that in the modern political climate, the US Constitution is fully frozen with no hope of amendment really ever again.
by adrian_b | 2025-05-18 04:58:12+00:00
Indeed, reentrance and recursivity and the use of stacks and/or heaps for dynamic memory allocation have appeared in programming languages that have descendants still used today only in 1960, in ALGOL 60 and LISP I. These features have become ubiquitous in the later programming languages, all of which have been at least partially inspired by ALGOL or LISP.

Fortran is the only surviving programming language older than that (first specification in 1954 and first implementation in 1956). Cobol is the only surviving programming language equally old with LISP and ALGOL, so that it has not been influenced by either of them. Thus now Fortran and Cobol are the only surviving programming languages from the era when only static memory allocation was used in programs, though their later versions have added most modern programming language features.