MurphyA/hacker-news huggingface dataset:
by loeg | 2025-04-20 19:37:57+00:00
I was curious about the mechanism.

https://www.nature.com/articles/s43856-025-00752-7

> YCT-529 works by interfering with vitamin A signaling necessary for sperm production and fertility.

> The importance of dietary vitamin A and retinoid signaling for male germ cell development and differentiation has been recognized for many years6. All trans-retinoic acid (Fig. 1a) is an active metabolite of vitamin A that exerts its function, at least partly, by binding to retinoic acid receptors (RARs). The RARs α, β, and γ, are encoded by the Rara, Rarb, and Rarg genes in mice, and Rarα and Rarγ have been validated as contraceptive targets by genetic knockouts resulting in male sterility7,8. Notably, the effects on spermatogenesis in the absence of RARα most resemble the loss of RAR signaling in vitamin A deficiency, and the mice are otherwise normal7,8. Further, the effects on spermatogenesis in animals treated orally with the dual RARα/RARγ antagonist BMS-189453 (Fig. 1a, b) closely phenocopied the absence of RARα function. Importantly, the resulting male sterility is reversible9,10,11. We, therefore, wished to identify RARα−selective inhibitors for potential male non-hormonal contraception. Our study describes the development of YCT-529, a highly selective RARα antagonist that reduces sperm counts in mice and non-human primates. Mating studies with male mice treated with 10 mg/kg/day for 4 weeks show that YCT-529 is 99% effective in preventing pregnancies and that the mice fully regain fertility after drug cessation.
by jandrese | 2025-04-20 19:38:40+00:00
Human suck at driving. Almost 2 million people are killed by vehicles on roads every year. While not all of this is due to limitations of vision, it's certainly a contributing factor. Tesla tries to handwave this saying that their systems don't text and drive, get distracted, etc..., but this strikes me as more "AI will become superintelligent real soon now and render humans obsolete" when actual experience with AI is that it is dumb, forgetful, and prone to hallucinations.
by goatlover | 2025-04-20 19:39:19+00:00
The Jewish Temple wasn't a church. Animals were sold there for people who couldn't bring animals with them to sacrifice on that Jewish holiday when they made pilgrimage to Jerusalem. There was plenty of disagreements between Jewish sects. We get the early Christianized perspective on some of the disagreements the Jesus movement had with the Pharisees and Sadducees, who also didn't agree with one another. Paul wasn't poor. He was an educated Pharisee who could write Greek, like Philo or Josephus. Some of the communities he wrote to like the one in Rome probably weren't poor either.

But the Jesus movement led by James the Just and Peter after his death probably was, if the Ebionites were their 2nd-4th century descendants.
by tbocek | 2025-04-20 19:40:27+00:00
This is probably due to this: https://github.com/ggml-org/llama.cpp/issues/12637. This GitHub issue is about interleaved sliding window attention (iSWA) not available in llama.cpp for Gemma 3. This could reduce the memory requirements a lot. They mentioned for a certain scenario, going from 62GB to 10GB.
by tripdout | 2025-04-20 19:40:32+00:00
17 out of 20. Was super easy until #10 and I had to stop and think more carefully (which was actually my first mistake), and then I got #14 and #15 wrong. The score was about what I expected, though - would've been surprised if it was <15 correct.

I wonder how much of this would come down to screen calibration / color accuracy? If everything's consistently off in 1 direction I guess not much, but I would imagine certain shades might appear effectively the same on some cheaper screens?
by namaria | 2025-04-20 19:41:03+00:00
Yeah this paper is great fodder for the LLM pixel dust argument.

They use a replacement model. It isn't even observing the LLM itself but a different architecture model. And it is very liberal with interpreting the patterns of activations seen in the replacement model with flowery language. It also include some very relevant caveats, such as:

"Our cross-layer transcoder is trained to mimic the activations of the underlying model at each layer. However, even when it accurately reconstructs the model’s activations, there is no guarantee that it does so via the same mechanisms."

https://transformer-circuits.pub/2025/attribution-graphs/met...

So basically the whole exercise might or might not be valid. But it generates some pretty interactive graphics and a nice blog post to reinforce the anthropomorphization discourse
by cosmic_cheese | 2025-04-20 19:41:12+00:00
Much of the frustration inspired by GNOME/GTK’s unthemability comes down to not having a few very simple knobs for users to tweak. Point in case, one of the primary reasons I used to theme GNOME desktops was to clean up Adwaita’s padding, which is utterly egregious for desktop usage. If GNOME just had a padding slider with 3-5 notches that’d go a long way and wouldn’t impair developers’ ability to build consistent apps in the least. Affordances like these are rarely given however and have to be fought for.

Aside from that, consistency and themability are not at all mutually exclusive. Back in the early days of OS X, theming by hacking system resource files (or patching them in memory via haxies[0]) was quite popular and for the most part, worked very well — generally, the only apps that didn’t play nice with themes were those sitting in the uncanny valley between native and custom, using bits of both, which tended to not be the highest quality applications anyway. This was way before Apple started pushing devs to parameterize their apps, too, and so similar theming capabilities today would work even better since themes can just tweak the parameterized fonts, colors, etc as needed to maintain coherence and usablity.

The real problem with GNOME/GTK is simply that it wasn’t designed with user customization in mind even as a remote possibility. A UI framework that did keep these things in mind combined with a strong dev culture of parametrization would make for a desktop that’s both customizable and consistent.

[0]: https://en.wikipedia.org/wiki/Unsanity
by randysalami | 2025-04-20 19:41:55+00:00
100%. We have built-in faculties for stopping and halting. My point wasn’t that humans physically need a monitor to determine when to stop or else suffer an infinite loop; sleep, eating, and death are perfectly effective at that. I was making a bit of a joke in the efficacy of agents being subjective around halting. A classical or quantum agent might go on forever to solve its goal, getting stuck and needing an outside monitor to reset or redefine it. Contrast that to a human agent; given a goal, they might never even try to solve it in the first place! Without outside monitors, systems of human agents may not start when needed or halt when optimal yet we’ve kept it going for thousands of years!
by Jensson | 2025-04-20 19:42:04+00:00
> I feel this misses the point and I think it dismisses attention heads and transformers

Those just makes it better at completing the text, but for very common riddles those tools still gets easily overruled by pretty simple text completion logic since the weights for those will be so extremely strong.

The point is that if you understand its a text completer then its easy to understand why it fails at these. To fix these properly you need to make it no longer try to complete text, and that is hard to do without breaking it.
by layer8 | 2025-04-20 19:43:02+00:00
This is from the creator of the ScienceClic YouTube channel [0]:

“As part of the next video, which will be out in a few weeks, l'd like to invite you to take part in an experiment about color perception. If you don't experience color blindness, l'd greatly appreciate it if you could take this test. Feel free to try it as many times as you like, think about it as a game!”

[0] https://youtube.com/@scienceclicen
by crazygringo | 2025-04-20 19:43:11+00:00
> Painting out these movie mistakes as part of a restoration is wrong. What's in the movie is in the movie, and altering the movie to this extent is a form of revisionist history. Cinema is worse off when over-aggressive restorations alter the action within the frame. To me, this is equivalent to swapping out an actor's performance with a different take, or changing the music score during an action sequence, or replacing a puppet creature with a computer graphics version of the same creature decades after release.

It's really not the equivalent though. I don't see anything wrong with fixing a license plate or removing a reflection or a modern-day wristwatch.

It's the equivalent of fixing a spelling error in a novel, or a wrong chord in sheet music. None of the filmmakers wanted those things there. They weren't done with intent. They were just mistakes.

Changing music or replacing a puppet with CG, of course I'm against. That's changing the art of it. Different music makes you feel different. A CG creature has a different personality. Just like you don't want to replace vocabulary in a novel to make it more modern-day.

I think it's usually pretty easy to distinguish the two. The first ones would have been corrected at the time if they'd noticed and gone for another take. They take us out of the movie if we notice them. The latter category is a reflection of the technology, resources, and intentional choices. They keep us in the world of moviemaking as it was at that time.
by bsder | 2025-04-20 19:43:16+00:00
> The zig community bewilders me at times with their love for lashing themselves. The sort of discussions which new sort of self-harm they'd love to enforce on everybody is borderline disturbing.

Personally, I find the idea that a compiler might be able to reach outside itself completely terrifying (Access the network or a database? Are you nuts?).

That should be 100% the job of a build system.

Now, you can certainly argue that generating a text file may or may not be the best way to reify the result back into the compiler. However, what the compiler gets and generates should be completely deterministic.
by KennyBlanken | 2025-04-20 19:43:25+00:00
> Small government: cut things we don't like (e.g. social programs)

Yeah, and guess how? By claiming the program is rife with abuse, demanding all sorts of record-keeping and auditing...and then a few years later shouting blue-bloody-murder about "administrative cost" in the program.

I wonder what the actual stats are for TANF and SNAP in terms of paper-pushing and auditing vs funds dispersed to recipients.

> remove freedoms for things we don't (e.g. LGBTQ)

Or the really big one: abortion. Doing things like passing legislation that forces doctors to say certain things to their patients, for example...and mandate medical procedures like forcing the mother to go through an ultrasound so they have to see the fetus and if it's old enough, listen to its heart.

Can you imagine how much outrage there would be if democrats passed legislation mandating doctors tell their patients that the vast overwhelming majority of scientific evidence supports efficacy of vaccines, and oh by the way, flu shots are now compulsory? They'd lose their goddamn minds and riot in the streets (er...again?)
by Gracana | 2025-04-20 19:43:56+00:00
You can probably find some long-form tuned models on HF. I've had decent results with QwQ-32B (which I can run on my desktop) and Mistral Large (which I have to run on my server). Generating and refining an outline before writing the whole piece can help, and you can also split the piece up into multiple outputs (working a paragraph or two at a time, for instance). So far I've found it to be a tough process, with mixed results.
by Jensson | 2025-04-20 19:44:06+00:00
> When you wrote your comment, you were completing text.

I didn't train to complete text though, I was primarily trained to make accurate responses.

And no, writing a response is not "completing text", I don't try to figure out what another person would write as a response, I write what I feel people need to read. That is a completely different thought process. If I tried to mimic what another commenter would have written it would look very different.
by goopthink | 2025-04-20 19:45:54+00:00
No disagreement, I think developer augmentation is an amazing productization of LLMs, and will likely be better at converting enterprises so paying customers.

But OpenAI has the best brand recognition and the largest user base, and they have the core tech powering all of this. Whats the number on “tons” of customers, given that these VSCode-spinoff/plugin GPT wrappers are sprouting around like mushrooms after a rain?

If this is a build-vs-buy decision, $3 billion? Is that worth 1/3rd of the money in the bank when they’re burning cash at insane rates just running servers, and the rest of the $30b fundraise is tenuous and there may not be a followup? I’m skeptical of the financial decision here.
by ck2 | 2025-04-20 19:45:55+00:00
Pretty sure ICE has sovereign immunity which is how they get away with this.

They also have deputized every state and even local law enforcement with their powers.

This has happened at least a dozen times this year, US Citizen detained for days.

Last story I read the judge immediately realized the mistake and wanted him released but ICE had put a hold on him so he had to go back to jail FOR NO CRIME, US CITIZEN BORN IN USA
by alabastervlog | 2025-04-20 19:46:17+00:00
I’m a lot more bothered by the change to the color grading in the “after” of Alien than the minor change to the effect, and by the picture looking way shittier in the “fixed” Goodfellas shot (the first is blu ray, the second “blu ray and streaming”, so hopefully the example was taken from streaming and that’s why it looks so much worse)
by digianarchist | 2025-04-20 19:47:27+00:00
Pretty sure SF has the same story as here in San Diego. Homelessness is not actually down but far less visible thanks to last year's Supreme Court ruling. No more tent cities downtown but now camps have shifted along federal highways.

https://www.npr.org/2024/06/28/nx-s1-4992010/supreme-court-h...
by NitpickLawyer | 2025-04-20 19:47:29+00:00
> but you'll know it when you see it.

I agree, but with the caveat that it's getting harder and harder with all the hype / doom cycles and all the goalpost moving that's happening in this space.

IMO if you took gemini2.5 / claude / o3 and showed it to people from ten / twenty years ago, they'd say that it is unmistakably AGI.
by mdaniel | 2025-04-20 19:47:39+00:00
> What callback url are you going to use?

There is actually a dedicated redirect_uri URN for fixing that: "urn:ietf:wg:oauth:2.0:oob" or, if the service is modern enough, RFC 8252 offers custom scheme support https://datatracker.ietf.org/doc/html/rfc8252#section-7.1
by madrox | 2025-04-20 19:48:42+00:00
I also found this take interesting coming from someone at ILM where they grafted Hayden Christensen into Return of the Jedi.

Though in this day and age I can’t help but ask “why not both?” It feels easy to add a choice to your viewing experience. If they can do it for Black Mirror then they can certainly ask up front “which version would you like to see?”
by ForOldHack | 2025-04-20 19:49:10+00:00
Which is course leads to the misnomer in the title: The integral was long solved by numeric means, more easily so with the inventions, but the proof of the solution, took a while... and as some other brilliant hacker-newsestition, pointed out, it because even easier with an ingenious u-substitution, related to the solution of the integral of 1/x discovered in the late 1930s...

( The solution is both possible, and proved, and there is a goddamned youtube video about the trick, and its not a minor trick either, like the proofs of int (sec (x)) or int (1/x ). )

In my text book, and current text books, it is said it cannot be resolved by elementary means, and it cannot, but it can be solved, and proven by one whopper of an idea.

The research is left as an exercise.
by CharlieDigital | 2025-04-20 19:49:11+00:00
Taiwan not far behind, but with a smaller population to start with.

Domestic policy seems to be hard to fix since it requires a massive cultural shift that may take a generation and requires big changes in the economic structure (income, employment law, child care capacity, etc.) that are going to have push back from corporations.

Immigration is also a bit of a challenge as SK, Japan, and Taiwan are all a bit xenophobic to extents and of course, the languages are not easy to gain proficiency.

I also think that this generation of people just think differently on matters of child rearing and what it means in life. (East Asian elder millennial w/2 kids). Even if money were no issue, I wouldn't want more kids.

Will be an interesting couple of decades.
by badsectoracula | 2025-04-20 19:49:55+00:00
> I as an app developer want to guarantee that my app looks good on your desktop

When your app doesn't follow how my desktop looks it doesn't look good on my desktop. And unsurprisingly most modern Gtk3 and especially Gtk4 apps do not look good on my desktop.

What you actually mean here is that you want to guarantee that your app looks good on your desktop, not mine.
by ChocolateGod | 2025-04-20 19:50:42+00:00
GTKs CSS engine is great for app developers because it's powerful and easy. You can make something look slick with little work.

But its terrible for themers, it's like running a CSS override on every site that runs Bootstrap and expecting it to work properly. It won't.

I don't run any themes anymore so it doesn't bother me.
by jimbokun | 2025-04-20 19:51:00+00:00
All of those are absolutely wrong.

In the vast majority of cases it’s “fixing” the original in this sense;

https://www.theguardian.com/world/2016/nov/18/painting-match...

Also, it’s important to be able to see these works as originally published. Otherwise, you are passing off a forgery as the original.
by ramesh31 | 2025-04-20 19:51:14+00:00
OpenAI has massive B2C brand value, but their enterprise offerings are scant. The era of consumer chatbot AI is coming to a close, and the winner will be the one who captures the B2B mindshare for real applications.

It’s about buying time as well. Could they put out a competitive product in less than six months? Maybe, but even that would leave them light years behind the market by the time it was ready.
by sarah-brussels | 2025-04-20 19:51:18+00:00
Thanks SO much for trying! Honestly, interacting with real people who have tried my game after thinking about it non stop for 16 years is truly exciting! Indeed, the AI part is necessary (well I don't want to say evil but...) in order to show off he game as it will be, and after posting it on Reddit last week, it was working like a dream with real live juries answering! My dream jury will be age 16 - 99, from every continent, every profession and culture...because I do believe the more diverse the jury, the better the verdict!
by crazygringo | 2025-04-20 19:51:58+00:00
Oh yeah. Totally agreed on not changing the color grading. That's as big as changing the music.

With blogs that take screenshots of 4K content though, sometimes that's using a media player with poor HDR color decoding though. Bad HDR always winds up with a green tint, that's the telltale sign. VLC is the worst with that.

But I don't think that's the case here. There are definitely a lot of rereleases with badly done color.
by swalling | 2025-04-20 19:52:45+00:00
The evidence that falsifies this idea is the fact that policies considered “progressive” in America are just called “universal status quo” in almost all countries with higher human development indexes and lower inequality. In fact some of the fastest growing cities in America, like Austin and Denver, are also famously progressive (not that they are perfect). Seems doubtful even total hegemony by conservatives would fix SF’s problems in short order. The common sense solutions do not fall exclusively on one end of the spectrum or the other.
by johnisgood | 2025-04-20 19:53:02+00:00
The similarity is not the same.

If no semen is emitted, the chance of pregnancy is null (more about it in my other comments).

Plus 90–99% suppression of ejaculation has been recorded and suggested that it has a potentially high contraceptive efficacy, so that is way better than withdrawal.

Experiment, maybe it affects you in a way that you get 99%, which would make it a very efficient hormone-free male birth control pill.

Side-note: personally I prefer IUDs, and/or a medication that has been extensively studied, so this pill can wait.
by Jensson | 2025-04-20 19:54:46+00:00
> IMO if you took gemini2.5 / claude / o3 and showed it to people from ten / twenty years ago, they'd say that it is unmistakably AGI.

No they wouldn't, since those still can't replace human white collar workers even at many very basic tasks.

Once AGI is here most white collar jobs are gone, you'd only need to hire geniuses at most.
by jpc0 | 2025-04-20 19:54:51+00:00
I don't think this is capabilities humans do not have, this to me is the one capability humans destinctly have over LLMs, the ability to introspect and shape their own future.

I feel this definition doesn't require a current LLM model to be able to change its own working but to be able to generate a guided next generation.

It's possible that LLMs can surpass human beings, purely because I believe we will inevitably be limited to short term storage constraints which LLMs will not. It will be a bandwidth vs througput question. An LLM will have a much larger although slightly slower store of knowledge than what human have. But will be much quicker than a human looking up and validating the data.

We aren't there yet.
by hilbert42 | 2025-04-20 19:55:27+00:00
There's no point further arguing about this matter with someone who hasn't lived through both pre and post mobile phone eras.

I'll just add this, I was amongst the first to ever own a cellular mobile phone. I owned several Motorola 'bricks' (DynaTAC) if you're old enough to know what that is, and before that I owned a mobile car phone in pre-cellular times, the nature of that tech was such that very few phone numbers were available—simply it was damed expensive and one had to be very keen to own one.

What I'm taking about is a lot more complex than your understanding (or that which you wish to admit to).
by aylmao | 2025-04-20 19:55:53+00:00
Some I liked and/or found interesting:

- https://maximecb.github.io/Turing-Drawings/#4,3,0,2,1,1,2,0,...

- https://maximecb.github.io/Turing-Drawings/#6,6,4,2,3,0,4,2,...

- https://maximecb.github.io/Turing-Drawings/#6,6,0,5,2,4,3,1,...

- https://maximecb.github.io/Turing-Drawings/#3,6,2,5,1,2,3,3,...
by 1024core | 2025-04-20 19:56:07+00:00
Agreed.

The fact is, SF's city government is fat and bloated with all sorts of cushy jobs for friends and family.

This article by the SJ Mercury News captures it best (how much we spend on staff in the city of SF): https://www.mercurynews.com/2024/08/23/5-charts-that-show-ho...
by aisenik | 2025-04-20 19:56:09+00:00
You'll be surprised to learn that neovaginas are also possessed by cis women. Trans men requiring vaginoplasty and receiving a uterine transplant are the nichest possible edge case, your "gotcha" is pure distraction.

Trans women will receive the modern* uterine transplant operation, this I can state with certainty. Birth is done via C-section as a requirement of the UTx operation, the vagina is required for discharge. I haven't been able to pay attention to the operation for a few years, but it is clear that you are operating from uninformed conjecture.

*The first uterine transplant was performed on a trans woman in Germany in 1930, Lili Elbe. This pioneering surgery lead to her death, as transplantation medicine was not adequately developed at that point in time.
by fsckboy | 2025-04-20 19:56:30+00:00
> FTA: Court documents say a Border Patrol agent arrested Hermosillo “at or near Nogales, Arizona, without proper immigration documents” and that Hermosillo admitted to illegally entering the U.S.

the article indicates he was visiting the area from where he lived in New Mexico and he was "lost", but it's not clear from the article whether he was seen crossing the border, or other evidence like that.