Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvements in red blood cell transfusion utilization following implementation of a single‐unit default for electronic ordering

The prevention of excessive allogeneic red blood cell (RBC) transfusion is an important component of patient blood management initiatives. In this investigation, changes in transfusion behaviors following modification of computerized physician order entry (CPOE) procedures for RBC transfusions to a single‐unit default quantity were assessed.
Bacterial effector kinases and strategies to identify their target host substrates

Post-translational modifications (PTMs) are critical in regulating protein function by altering chemical characteristics of proteins. Phosphorylation is an integral PTM, catalyzed by kinases and reversibly removed by phosphatases, that modulates many cellular processes in response to stimuli in all living organisms. Consequently, bacterial pathogens have evolved to secrete effectors capable of manipulating host phosphorylation pathways as a common infection strategy. Given the importance of protein phosphorylation in infection, recent advances in sequence and structural homology search have significantly expanded the discovery of a multitude of bacterial effectors with kinase activity in pathogenic bacteria. Although challenges exist due to complexity of phosphorylation networks in host cells and transient interactions between kinases and substrates, approaches are continuously being developed and applied to identify bacterial effector kinases and their host substrates. In this review, we illustrate the importance of exploiting phosphorylation in host cells by bacterial pathogens via the action of effector kinases and how these effector kinases contribute to virulence through the manipulation of diverse host signaling pathways. We also highlight recent developments in the identification of bacterial effector kinases and a variety of techniques to characterize kinase-substrate interactions in host cells. Identification of host substrates provides new insights for regulation of host signaling during microbial infection and may serve as foundation for developing interventions to treat infection by blocking the activity of secreted effector kinases.
Perceived Risk of Diabetes Among Vietnamese Americans With Prediabetes: Mixed Methods Study

Background Vietnamese Americans have a relatively high risk of developing diabetes at younger ages, yet there are no published studies exploring their risk perceptions. Objective This mixed methods study describes perceived diabetes risk in the context of an underserved population. Methods This study was guided by the Common-Sense Model of Self-Regulation. Snowball sampling was used to recruit 10 Vietnamese Americans with prediabetes and achieve data saturation. Qualitative and quantitative descriptive methodologies with data transformation were used to analyze data from semistructured interviews and questionnaires to explore the dimensions of perceived diabetes risk. Results Participants were between the ages of 30 and 75 years with diversity also noted in diabetes risk factors. The 3 risk perception domains from qualitative data were risk factors, disease severity, and preventing diabetes. The main perceived diabetes risk factors were eating habits (including cultural influences), sedentary lifestyle, and family history of diabetes. Quantitative data supported qualitative findings of a low-to-moderate level of perceived diabetes risk. Despite the lower levels of perceived diabetes risk, Vietnamese Americans do believe that the severity of diabetes is a “big concern. ” Conclusions Vietnamese Americans with prediabetes have a low-to-moderate level of perceived diabetes risk. Understanding the perceived diabetes risk in this population provides a foundation for diabetes prevention interventions that consider cultural influences on diet and exercise.
On linear block codes and deterministic compressive sampling

We suggest and explore a parallelism between linear block code parity check matrices and binary zero/one measurement matrices for compressed sensing. The resulting family of deterministic compressive samplers renders itself to the development of eective and ecient recovery algorithms for sparse signals that are not ℓ1-based. Experimental results that we include herein demonstrate the utility of the presented developments.
Potential chirp-free characteristics (negative chirp parameter) in electroabsorption modulation using a wide tensile-strained quantum well structure

The possibility of nearly chirp‐free electroabsorption (EA) characteristics in intensity modulation at an operating wavelength of 1.55 μm is studied theoretically. The TE‐polarized EA spectra, their Kramers–Kronig (K–K) transformed refractive index changes, and the chirp parameters derived under both small‐signal and large‐signal conditions are calculated including excitonic effect within the framework of the effective mass theory. We investigate on the basis of the simulated EA results how to keep chirp parameters always negative. This can be accomplished by following two successive steps: (1) Widen the well width to increase the Stark shift. This makes it easier for the chirp parameter to turn negative at smaller applied electric field. (2) Apply tensile strain to the wide QW to induce a negative refractive index changes even in the vicinity of zero electric fields, indicating that there exists a desirable condition where the chirp parameter is negative independently of applied fields.
Absolute differential cross sections for elastic and inelastic electron scattering from benzene with 1 kev impact energy

The absolute generalized oscillator strength and absolute inelastic differential cross section have been determined, as a function of the momentum transfer, for the 1E1u + 1B1u ← 1Ag transition in the benzene molecule. A previously described electron energy-loss spectrometer, featuring a Wien-filter velocity analyser, has been used. Employing 1000 eV incident electron energy and 1.0 eV energy resolution, absolute oscillator strength distribution as a function of electron energy loss was obtained in the 2–8° scattering angle range. The absolute elastic differential cross section was also determined spanning an angular range of 2°–14°. The photoabsorption spectrum converted from the electron energy-loss spectrum was compared with the interstellar extinction curve where we confirm the proportionality between the cross section and extinction.
Exposure to Steady‐State Noise and Impairment of Hearing

A damage risk criterion for exposure to noise is specified primarily in terms of the impairment of speech communication as the result of noise‐induced deafness. The criterion allows as permissible any noise exposure that, on the average, causes a temporary threshold shift measured 2 min after exposure, in the average normal ear, of no more than 10 dB at 1000 cps or below; 15 dB at 2000 cps; or 20 dB at 3000 cps or above. It is held that after 10 years of near daily exposure to such a noise, the average person will have a stable hearing level, relative to present‐day audiometric zero, of a similar magnitude. To determine what kinds of sounds and durations of exposure would meet this criterion, twelve ears were exposed to bands of filtered, random noise for durations ranging from 3 min to 8 h. Temporary threshold shifts for pure tones were obtained by comparing pre‐ and post‐exposure audiograms. From these data functions were obtained which show the sound‐pressure level, durations, bandwidth, and center fre.
"Overqualified" ? Research on the Influence Mechanism of Illegitimate Tasks on Employees' Creative Performance

As a new type of stressor in the workplace, illegitimate tasks (IT) bring some confusion to employees' rational allocation of resources, and reduce employees' work passion because of their offensive professional identity. In turn, it reduces the creative performance that can benefit the long-term development of the organization and the individual. Based on the conservation of resources theory and the stress-as-offense-to-self theory (SOS), using the method of multi-period survey data, this paper discusses the influence mechanism of illegitimate tasks on employee creative performance (CP) from a cognitive perspective. The results show that IT are negatively related to employee CP, and can be indirectly related through organization-based self-esteem (OBSE), that is, OBSE plays an intermediary role between IT and employee CP. In addition, the study found that psychological resilience (PR) plays a double moderating role in the direct or indirect relationship between IT and employee CP. This study expands and deepens the discussion of the mechanism between IT and employee CP, and lays a foundation for promoting the follow-up research of IT.
SANDWICH PANELS WITH INTERLAYER SLIP SUBJECTED TO THERMAL LOADS

Thermally induced bending of sandwich panels composed of three symmetrically arranged layers is studied under the consideration of plane strain. Moderately thick elastic layers made of dissimilar transverse isotropic materials are considered. Analyzing two special cases of interlaminar connections, namely, perfect bond and elastic interlayer slip, a complete analogy between the corresponding initial boundary-value problems is derived. Subsequently, the response of the panel with elastic interlayer slip can be determined directly from the solution of the perfectly bonded sandwich panel with moderately thick faces by substituting effective parameters.
Versatile application of a compact compound imaging system

Based on compound-eye imaging, a compact image capturing system called TOMBO (Thin Observation Module by Bound Optics) is developed. The TOMBO system consists of a microlens array, a signal separator, and an image sensor. The captured compound image is a set of low-resolution unit images, which is processed to retrieve information of the target object. Owing to flexibility in configuration of the compound imaging system, the TOMBO system can be used for versatile applications. Possible configurations of the TOMBO system are summarized. As examples of the applications, multispectral imaging, 3-D data acquisition, short range imaging, gonio-imaging, and 3-D image interface are presented.
Whole-Genome Sequence of the Novel Rubrobacter taiwanensis Strain Yellowstone, Isolated from Yellowstone National Park

The family Rubrobacteraceae is often represented by its thermophilic and radiotolerant species. Rubrobacter radiotolerans and Rubrobacter xylanophilus have been extensively studied, contributing to defining the characteristics of the family. ABSTRACT The family Rubrobacteraceae is often represented by its thermophilic and radiotolerant species. Rubrobacter radiotolerans and Rubrobacter xylanophilus have been extensively studied, contributing to defining the characteristics of the family. We have now sequenced the genome of a Rubrobacter taiwanensis strain, isolated from Yellowstone National Park, to further characterize the family.
LPIH2V: LncRNA-protein interactions prediction using HIN2Vec based on heterogeneous networks model

LncRNA-protein interaction plays an important role in the development and treatment of many human diseases. As the experimental approaches to determine lncRNA–protein interactions are expensive and time-consuming, considering that there are few calculation methods, therefore, it is urgent to develop efficient and accurate methods to predict lncRNA-protein interactions. In this work, a model for heterogeneous network embedding based on meta-path, namely LPIH2V, is proposed. The heterogeneous network is composed of lncRNA similarity networks, protein similarity networks, and known lncRNA-protein interaction networks. The behavioral features are extracted in a heterogeneous network using the HIN2Vec method of network embedding. The results showed that LPIH2V obtains an AUC of 0.97 and ACC of 0.95 in the 5-fold cross-validation test. The model successfully showed superiority and good generalization ability. Compared to other models, LPIH2V not only extracts attribute characteristics by similarity, but also acquires behavior properties by meta-path wandering in heterogeneous networks. LPIH2V would be beneficial in forecasting interactions between lncRNA and protein.
Numerical Study on Thermal Stress of High Temperature Proton Exchange Membrane Fuel Cells during Start-Up Process

High-temperature proton-exchange membrane fuel cells (HT-PEMFCs) with phosphoric-doped polybenzimidazole (PBI) membranes have a higher operating temperature compared to the PEMFCs operating below 373.15 K. The fuel cell is first heated from room temperature to the minimum operating temperature to avoid the generation of liquid water. The existence of liquid water can result in the loss of phosphoric acid and then affect the cell performance. In this study, the start-up process of HT-PEMFCs is numerically studied by establishing a three-dimensional non-isothermal mathematical model. Preheated gas is supplied into gas flow channels to heat the fuel cell, and then voltage load is applied to accelerate the start-up process. Effects of voltage (0.9 V, 0.7 V and 0.5 V) and flow arrangement (co-flow and counter flow) on temperature, current density, proton conductivity and stress distributions of fuel cells are examined. It is found that the maximum stress is increased when a lower voltage is adopted, and the counter-flow arrangement provides a more uniform stress distribution than that of co-flow arrangement.
On local linear transform and Gabor filter representation of texture

Presents a comparative study of two approaches to texture representation under the computational framework of multichannel spatial filtering. The two approaches compared are the Gabor multichannel receptive field model and local linear transform techniques. In the local linear transform approach, it is shown that the orthogonal masks derived from the discrete cosine transform (DCT) have some interesting features which resemble Gabor filters. Although the texture representation concepts of orthogonal DCT basis masks and Gabor filters are fundamentally different, it is demonstrated that the representational structure of both approaches is inherently identical. This allows one to devise an experiment to compare the two approaches in terms of their computational efficiency and the representation potential of the extracted texture features. The performance of the approaches is assessed by means of their segmentation result accuracy on a set of images composed of Brodatz textures. <<ETX>>
Moduli space of semistable pairs on a curve

Let X be a smooth projective curve over an algebraically closed field k of any characteristic. A stable pair (E, <p) on X, as defined by Hitchin [2], is a vector bundle E on X together with a morphism <j>: E^>QX ® E of (^-modules such that for any ^-invariant proper subbundle F of E, the inequality JU(F) < /i(£) holds (where JU = degree/rank). In [2], Hitchin has proved that the set of all isomorphism classes of stable pairs of rank 2 over a compact Riemann surface can be given the structure of a complex manifold which has the coarse moduli property in the analytic category. In this paper we construct a coarse moduli scheme within the algebraic category in the following more general setup. Instead of taking (£, 0) with cf>: £ • Qx <8> E, we consider the more general situation where <p takes values in any fixed line bundle L on X. We do not place any restriction on the rank of E. In § 5 below, we complete the proof that for any line bundle L, there exists a coarse moduli scheme M(r, d, L) for (5-equivalence classes of) semistable pairs (E, <p: E—»L®£) of rank r, degree d, on X. The scheme M(r, d, L) is quasi-projective, and has an open subscheme M' which is the moduli scheme of stable pairs. Our construction of M is a generalization of the construction of the moduli of ordinary vector bundles; for an exposition of the latter, see [7] or [9]. In § 6, we show that the Hitchin morphism from M(r, d, L) to H°(X, L)x . x H°(X, U), which maps a pair (E, <j>) to its characteristic polynomial, is a proper morphism. In § 7, we study some properties of the scheme M(r, d, L). From these it follows, in particular, that M(2, d, Qx) is a non-singular variety (irreducible and reduced) when d is odd.
JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T-cell lymphoma, nasal type

The inactivation of tumor suppressor gene positive regulatory domain containing I (PRDM1) and activation of signal transducer and activator of transcription 3 (STAT3) have been detected in the majority of extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT) cases. In the present study, their association with and effects on the clinicopathologic features of EN-NK/T-NT are described. PRDM1 was revealed to be expressed in 19 out of 58 patients (32.8%) with EN-NK/T-NT, and phosphorylated STAT3 was overexpressed in 42 out of 58 (72.4%). Oncogenic pathways were investigated by NanoString encounter technology in 5 PRDM1(+) and 5 PRDM1(−) EN-NK/T-NT specimens. Multiple oncogenic pathways involved in cell apoptosis, cellcycle (CC) and angiogenesis were discriminately activated in EN-NK/T-NT cases, and in PRDM1(+) cases in particular. The sustained activation of the Janus kinase 3 (JAK)/STAT3 pathway was more pronounced. In addition, missense mutations in the SRC homology 2 domain of STAT3 were detected in 7 out of 37 EN-NK/T-NT cases (18.92%), and the acquired mutation was related to the activation of the JAK3/STAT3 pathway. The downregulation of PRDM1 and upregulation of phospho-STAT3 (Tyr705) were associated with angiocentric infiltration of EN-NK/T-NT (P=0.039). Notably, the prognosis of patients in the PRDM1(+)/STAT3 [mutated (mut-)] group was considerably improved than that of patients in the STAT3(mut+)/PRDM(−) group (P=0.037). In addition, the inhibition of NK/T cell lymphoma cell lines by Stattic and tofacitinib could suppress cell proliferation by inducing cell apoptosis or arresting the CC. The present results revealed that the JAK3/STAT3 oncogenic pathway and PRDM1 expression could stratify clinicopathologic features of EN-NK/T-NT. The inhibition of the JAK3/STAT3 pathway may serve as a treatment option for EN-NK/T-NT.
Upper bound calculations of ATR performance for ladar sensors

The use of robust and representative synthetic imagery data to test and evaluate automatic target recognition (ATR) systems has long been desired but generally considered beyond the current state of the art. The use of synthetic data is investigated here to calculate upper bounds on potential ATR system performance. This paper presents the use of synthetically generated imagery templates as a means of developing upper bounds of ATR performance for laser radar based seekers. This approach employs a synthetic scene generation capability and integrates it with error models that represent decrements in performance due to resolution, noise and geometric distortion resulting from the sensing process. This paper describes the modeling approach take and presents preliminary results. The model is currently undergoing testing against real imagery and is being used to select test sets to more effectively evaluate ATR's.
Dissipationless Collapses in Modified Newtonian Dynamics

Dissipationless collapses in modified Newtonian dynamics (MOND) are studied by using a new particle-mesh N-body code based on our numerical MOND potential solver. We found that low surface density end products have shallower inner density profiles, flatter radial velocity dispersion profiles, and more radially anisotropic orbital distributions than high surface density end products. The projected density profiles of the final virialized systems are well described by Sérsic profiles with index m ≲ 4, down to m ~ 2 for a deep MOND collapse. Consistent with observations of elliptical galaxies, the MOND end products, if interpreted in the context of Newtonian gravity, would appear to have little or no dark matter within the effective radius. However, we found it impossible (under the assumption of constant stellar mass-to-light ratio) to simultaneously place the resulting systems on the observed Kormendy, Faber-Jackson, and fundamental plane relations of elliptical galaxies. Finally, the simulations provide strong evidence that phase mixing is less effective in MOND than in Newtonian gravity.
TRPC channels are not required for graded persistent activity in entorhinal cortex neurons

Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short‐lasting form of memory involves sustained (“persistent”) neuronal firing which may be generated by cell‐autonomous biophysical properties of neurons or/and neural circuit dynamics. A number of studies from brain slices reports intrinsically generated persistent firing in cortical excitatory neurons following suprathreshold depolarization by intracellular current injection. In layer V (LV) neurons of the medial entorhinal cortex (mEC) persistent firing depends on the activation of cholinergic muscarinic receptors and is mediated by a calcium‐activated nonselective cation current (ICAN). The molecular identity of this conductance remains, however, unknown. Recently, it has been suggested that the underlying ion channels belong to the canonical transient receptor potential (TRPC) channel family and include heterotetramers of TRPC1/5, TRPC1/4, and/or TRPC1/4/5 channels. While this suggestion was based on pharmacological experiments and on effects of TRP‐interacting peptides, an unambiguous proof based on TRPC channel‐depleted animals is pending. Here, we used two different lines of TRPC channel knockout mice, either lacking TRPC1‐, TRPC4‐, and TRPC5‐containing channels or lacking all seven members of the TRPC family. We report unchanged persistent activity in mEC LV neurons in these animals, ruling out that muscarinic‐dependent persistent activity depends on TRPC channels.
Ultralow-threshold (50 A/cm2) strained single-quantum-well GaInAsSb/AlGaAsSb lasers emitting at 2.05 μm

Strained single-quantum-well, broadened-waveguide GaInAsSb/AlGaAsSb diode lasers have exhibited room-temperature threshold current densities as low as 50 A/cm2, one of the lowest values reported for diode lasers at room temperature. These lasers, grown by molecular beam epitaxy, have emission wavelengths of ∼2.05 μm, characteristic temperature of 65 K, internal quantum efficiency of 95%, and internal loss coefficient of 7 cm−1. Single-ended cw power of 1 W is obtained for a 100-μm aperture.