Miracle-dz/UniFAR-FTUs huggingface dataset:
Ovarian secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one during rat estrous cycle in chronological relation to pituitary release of luteinizing hormone.

The secretory rates of progesterone and 20α-hydroxypregn-4-en-3-one (20α-OHP) from the ovary and the concentration of both progestins in the ovarian tissues were determined during the estrous cycle in 4-day cyclic rats illuminated 12 hrs. a day (8a.m. to 8 p.m.). The progesterone secretion increased twice a cycle, markedly on the evening (peak at 7p.m.) of the day of proestrus and slightly on the afternoon of the day of early diestrus. The prompt and tremendous increase of progesterone secretion at the preovulatory stage almost synchronized with the release of luteinizing hormone (LH). It was also demonstrated that a marked preovulatory rise of progesterone secretion depended upon pituitary LH discharge, and a slight increase in both progestin secretions-at early diestrus was not dependent on the pituitary function at that stage. These facts together with the following fmdings, (a) an enormous increase in the ratio of progesterone over total progestin (progesterone plus 20α-OH-P) in the ovarian venous blood at the preovulatory stage, (b) the secretory pattern of 20α-OH-P which roughly paralleled with that of progesterone at the diestrous phase, and (c) a higher concentration of progesterone in the ovary as compared with that of 20α-OH-P at the diestrous phase and its reverse relationship of the concentrations at the stages of proestrus and estrus, suggest that a drastic shift occurs at the sites of progesterone synthesis from the involuting corpora lutea to the LH sensitive ripening follicles or interstitial tissues under the influence of released LH which exerts both luteinizing effect and steroidogenic action on the ovary, and the present data suggest that the newly developed corpora lutea after ovulation gain the automaticity of progestin synthesis, storage and secretion independently of the pituitary function.
Biology and prognostic factors in CLL

The immunoglobulin heavy and light chain genes which encode the antigen binding site of the B cell receptor (BCR) in CLL may be either mutated or unmutated raising the question as to whether CLL originates from a single, or more than one target cell. Microarray studies performed to address this issue have been inconclusive but do show a common ‘‘CLL signature’’ quite similar to that of both normal naive unmutated B cells and mutated memory B cells. However, the pattern of surface antigen expression which is consistent with an activated B cell, the presence of short telomeres reflecting multiple cell divisions, and the finding of biased IgVH gene usage all suggest that unmutated CLL cells have been exposed to antigen. The analysis of IgVH gene usage in large numbers of patients with CLL has recently revealed that there are several sub-groups of patients (comprising approximately 10% of all cases of CLL) that have highly or moderately homologous CDR3 regions, encoded by V D and J genes, and critical for antigen binding. There is a B/1 in 10 chance of normal B cells having identical CDR3’s, suggesting a role for specific antigen(s) in the pathogenesis of CLL. Whether antigen is responsible for selecting B cell clones for expansion and increasing the chance of a transforming event or is responsible for the subsequent survival and expansion of the leukaemic clone remains uncertain. The ability of CLL cells to signal through the BCR is diminished as compared to normal B cells, and is especially poor in the mutated subgroup. There are a number of hypotheses to account for this difference in signalling between the two mutational subsets. These include an inability to bind antigen through the BCR, and/or a defect in the organization of the BCR in mutated cases, and the expression of Zap 70, a key molecule in T-cell signalling, in the majority of unmutated cases. The increased cell turnover in unmutated CLL may favor the acquisition of poor prognostic secondary cytogenetic abnormalities.
Uterine Fibroid Pseudocapsule: an Update of its Importance in Fibroid Management and Female Reproduction

Uterine fibroids or myomas are the most common benign tumors of the female genital tracts, consisting mainly of smooth muscle cells with different amounts of fibrous tissue and are benign. During its growth, fibroid causes compressive phenomena on the surrounding myometrium, that for ischemic phenomena, produce a sort of pseudocapsule, constituted by a surrounding network of collagen fibers, neurofibers and blood vessels, as a separate fibroneurovascular tissue. Occasionally the pseudocapsule surface is interrupted by collagen fibers and vessels that anchor the fibroid to myometrium, well represented in microscopic sections. At the ultrastructural level, visualized by transmission electron microscopy, the pseudocapsule cells have the features of smooth muscle cells similar to the myometrium. So, the pseudocapsules are part of the myometrium which compresses the leiomyoma. Studies confirmed preliminary evidence that pseudocapsules is rich of neuropeptides together with their related fibers, as a neurovascular bundle, containing a vascular network rich in neurotransmitters, as a neurovascular bundle, with biological very important biological functions and a significant impact on the reproductive uterine functions. In this paper, after a review of all papers in such topic, I summarize the importance of this small structure in the context of the myometrium, for the purpose anatomical, pathophysiological and reproductive systems.
Mentoring School-Based Careers in Graduate Education

ABSTRACT Competition has increased in mental health practice. Still, while opportunities in private practice have lessened, school-based mental health practice has witnessed steady growth. Mentoring relationships can serve a critical role in fostering knowledge of school-based careers and about practitioner and higher education opportunities in school psychology. Defined as a process whereby a senior colleague guides, supports, and assists a less developed colleague, mentoring can be critical in fostering practitioner and training careers. This article examines positive contributions of mentoring and provides an example of one successful mentoring relationship involving a 38-year-old student pursuing a graduate program leading to credentialing as a Certified School Psychologist.
Educating Reason: Rationality, Critical Thinking and Education

Preface Acknowledgements Introduction :Rationality, Critical Thinking and Education 1: Three Conceptions of Critical Thinking 2: The Reasons Conceptions 3: The Justification of Critcal Thinking as an Educational Ideal 4: The Ideology Objection 5: The Indoctrination Objection 6: Science Education 7: Minimun Competency Testing Postscript: Towards a Theory of Rationality Notes Bibliography Index.
The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production

A key event in the pathogenesis of Alzheimer’s disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs), on Aβ production in AD cellular and animal models. We found that lansoprazole enhances Aβ37, Aβ40 and Aβ42 production and lowers Aβ38 levels on amyloid cell models. Interestingly, acute lansoprazole treatment in wild type and AD transgenic mice promoted higher Aβ40 levels in brain, indicating that lansoprazole may also exacerbate Aβ production in vivo. Overall, our data presents for the first time that PPIs can affect amyloid metabolism, both in vitro and in vivo.
Variables sociodemográficas y síndrome de burnout en una muestra multiocupacional del Hospital Psiquiátrico Penitenciario de Sevilla

This study aims to assess the relationship between sociodemographic variable and the burnout syndrome in a multiocupational sample of the Hospital Psychiatric Prison of Seville. The sample consisted of 136 workers of the Hospital Psychiatric Prison (93% of the total staff) that were gathered in three groups (security, services and treatment) their level of contact with the inmates was also taked into account. Results show that prison employees with high levels of contact with the inmates experience higher levels of depersonalization and were less satisfied with their personal accomplishment at work than the personnel with less contact. Significant differences were also found among the three groups (security, services and treatment). Depersonalization and low personal accomplishment were higher in the security officer’s group. On the other hand, lower levels of depersonalization were found between women and personnel with university studies. This study also shows that to have an only child is positively related to depersonalization and emotional exhaustion.
Thinking mathematically : a framework for developing positive attitudes amongst undergraduates

This thesis tests the hypothesis that problem-solving activities caused positive changes in students attitudes towards mathematics. A pilot test, carried out in a problem-solving course at the University of Warwick, tested possible questions that would indicate change of attitudes. The findings indicate that the course affected students attitudes to mathematics in what was considered a positive manner. Using that experience gained through the pilot study, the main study was carried out at Universiti Teknologi Malaysia (UTM) in which data was collected from 44 students who took the course in problem-solving taught by the researcher. A pre-test, post-test and a delayed post-test (six months later) were administered, which included interviews with selected students and staff. To establish what might be considered a positive change, the staff at the Mathematics Department were asked what attitudes they would expect students have as a result of the mathematics teaching at the University, and then specify the attitudes they would prefer students to have. The direction of change between the two responses were considered to be positive, and this is defined as the "desired direction of change". The results show that the problem-solving course affected students attitudes such that the change, identified as the difference between pretest and post-test results, was largely in the desired direction of change. However, when students return to normal mathematics lectures many of the indicators reverted in the opposite direction; away from what the staff preferred.
Stability and Completion of Zeno Equilibria in Lagrangian Hybrid Systems

This paper studies Lagrangian hybrid systems, which are a special class of hybrid systems modeling mechanical systems with unilateral constraints that are undergoing impacts. This class of systems naturally display Zeno behavior-an infinite number of discrete transitions that occur in finite time, leading to the convergence of solutions to limit sets called Zeno equilibria. This paper derives simple conditions for stability of Zeno equilibria. Utilizing these results and the constructive techniques used to prove them, the paper introduces the notion of a completed hybrid system which is an extended hybrid system model allowing for the extension of solutions beyond Zeno points. A procedure for practical simulation of completed hybrid systems is outlined, and conditions guaranteeing upper bounds on the incurred numerical error are derived. Finally, we discuss an application of these results to the stability of unilaterally constrained motion of mechanical systems under perturbations that violate the constraint.
Le Plan de Développement International de Bruxelles (PDI). Promesses de développements immobiliers et d’inégalités croissantes ?

L’adoption, fin 2007, d’un Plan de Developpement International (PDI) par le gouvernement regional marque une transition significative dans les politiques urbaines a Bruxelles. Ce texte cherche a mettre en evidence les options essentielles du PDI et en propose une critique. A nos yeux, le PDI signale essentiellement la formalisation d’une strategie, relativement neuve a Bruxelles, misant sur la valorisation de portions importantes du territoire regional aux fins de developpements immobiliers prives a caractere speculatif et censes fonctionner comme nouveaux leviers de « revitalisation » urbaine. Le PDI bruxellois s’inscrit en cela dans une tendance lourde a la generalisation de politiques urbaines d’inspiration neoliberale, centrees sur l’encouragement du reinvestissement des villes centrales et qui ne prennent pas la mesure de leurs effets d’approfondissement des divisions sociales et spatiales de la ville.
Matriliny and the New Intestate Succession Law of Ghana

ResumeCet article examine les implications pour les Akans matrilineaires de quatre lois promulguees en juin 1985 par le gouvernement du Ghana sur la devolution de l'heritage de quiconque meurt sans laisser de testament ecrit ou oral (proprieteintestate), sur l'enregistrement des mariages et divorces coutumiers, et sur l'enregistrement de la propriete familiale (tenant compte de tous ses membres) (Lois PNDC 111–114). Pour les Akans matrilineaires, les lois sabotent la structure tout entiere de leur organisation socio-economique. Mais les changements sont devenus necessaires a cause de ceux qui se produisent dans la societe. Le menage conjugal emerge peu a peu comme une unite d'organisation socio-economique et les mariages mixtes entre hommes Akan et femmes non-Akan produisent des enfants sans heritage automatique puisqu'ils n'appartiennent ni au systeme patriarcal ni au systeme matriarcal. En assignant sept-huitiemes de la propriete intestate a la famille nucleaire, la loi accorde a la veuve et aux enfants.
Daily Quantity of Infant Leg Movement: Wearable Sensor Algorithm and Relationship to Walking Onset

Background: Normative values are lacking for daily quantity of infant leg movements. This is critical for understanding the relationship between the quantity of leg movements and onset of independent walking, and will begin to inform early therapy intervention for infants at risk for developmental delay. Methods: We used wearable inertial movement sensors to record full-day leg movement activity from 12 infants with typical development, ages 1–12 months. Each infant was tested three times across 5 months, and followed until the onset of independent walking. We developed and validated an algorithm to identify infant-produced leg movements. Results: Infants moved their legs tens of thousands of times per day. There was a significant effect of leg movement quantity on walking onset. Infants who moved their legs more walked later than infants who moved their legs less, even when adjusting for age, developmental level or percentile length. We will need a much larger sample to adequately capture and describe the effect of movement experience on developmental rate. Our algorithm defines a leg movement in a specific way (each pause or change in direction is counted as a new movement), and further assessment of movement characteristics are necessary before we can fully understand and interpret our finding that infants who moved their legs more walked later than infants who moved their legs less. Conclusions: We have shown that typically-developing infants produce thousands of leg movements in a typical day, and that this can be accurately captured in the home environment using wearable sensors. In our small sample we can identify there is an effect of leg movement quantity on walking onset, however we cannot fully explain it.
The fundamental role of ecological feedback mechanisms for the adaptive management of seagrass ecosystems – a review

Seagrass meadows are vital ecosystems in coastal zones worldwide, but are also under global threat. One of the major hurdles restricting the success of seagrass conservation and restoration is our limited understanding of ecological feedback mechanisms. In these ecosystems, multiple, self‐reinforcing feedbacks can undermine conservation efforts by masking environmental impacts until the decline is precipitous, or alternatively they can inhibit seagrass recovery in spite of restoration efforts. However, no clear framework yet exists for identifying or dealing with feedbacks to improve the management of seagrass ecosystems. Here we review the causes and consequences of multiple feedbacks between seagrass and biotic and/or abiotic processes. We demonstrate how feedbacks have the potential to impose or reinforce regimes of either seagrass dominance or unvegetated substrate, and how the strength and importance of these feedbacks vary across environmental gradients. Although a myriad of feedbacks have now been identified, the co‐occurrence and likely interaction among feedbacks has largely been overlooked to date due to difficulties in analysis and detection. Here we take a fundamental step forward by modelling the interactions among two distinct above‐ and belowground feedbacks to demonstrate that interacting feedbacks are likely to be important for ecosystem resilience. On this basis, we propose a five‐step adaptive management plan to address feedback dynamics for effective conservation and restoration strategies. The management plan provides guidance to aid in the identification and prioritisation of likely feedbacks in different seagrass ecosystems.
LEXICALLY-BASED VOWEL DISPERSION : A CASE STUDY FOR DUTCH 1

The 'vowel dispersion theory' states that the acoustic structure of the vowel inventory in a language can be explained by optimizing the acoustic inter-vowel contrast, under the constraint of articulatory conditions. In this paper, the primacy of the acoustic principles of contrast and effort is questioned by considering the possible effect of the lexicon on vowel dispersion. As an extreme point of view, the need for acoustic contrast between two vowels will be assumed to be determined only by the 'functional load' of the vowel opposition. This functional load is determined by the lexicon. The results for Dutch indicate that the functional load explains at least a part of the acoustic structure of the Dutch vowel inventory. Since the model is tested for one language only, we emphasize the used methodology, rather than the language-specific results.
Bug busters

One way to deal with bugs is to avoid them entirely. The approach would be wasteful because we'd be underutilizing the many automated tools and techniques that can catch bugs for us. Most tools for eliminating bugs work by tightening the specifications of what we build. At the program code level, tighter specifications affect the operations allowed on various data types, our program's behavior, and our code's style. Furthermore, we can use many different approaches to verify that our code is on track: the programming language, its compiler, specialized tools, libraries, and embedded tests are our most obvious friends. We can delegate bug busting to code. Many libraries come with hooks or specialized builds that can catch questionable argument values, resource leaks, and wrong ordering of function calls. Bugs many be a fact of life, but they're not inevitable. We have some powerful tools to find them before they mess with our programs, and the good news is that these tools get better every year.
Challenges to Success in Higher Education: An Examination of Educational Challenges from the Voices of College-Bound Black Males

Abstract:In recent years, researchers have devoted much discussion to finding ways to increase the academic success of Black males in K-12 and higher education. Despite this emphasis, Black male enrollment in higher education stands at 4.5%, which is the same as it was in 1976. One factor noted by researchers for the stagnation among Black male college enrollment is their disproportionate departure from high school. Therefore, this qualitative study of college-bound high school seniors discusses four critical factors that contribute to Black males premature departure from high school. Implications for practice and future research are discussed.
LINDA: distributed web-of-data-scale entity matching

Linked Data has emerged as a powerful way of interconnecting structured data on the Web. However, the cross-linkage between Linked Data sources is not as extensive as one would hope for. In this paper, we formalize the task of automatically creating "sameAs" links across data sources in a globally consistent manner. Our algorithm, presented in a multi-core as well as a distributed version, achieves this link generation by accounting for joint evidence of a match. Experiments confirm that our system scales beyond 100 million entities and delivers highly accurate results despite the vast heterogeneity and daunting scale.
Microfinanciamiento para la vivienda progresiva en México: evaluación de los efectos sociales de Patrimonio Hoy en Zinacantepec, Estado de México

Mediante la comparacion estadistica de caracteristicas de bienestar para dos grupos de hogares del municipio de Zinacantepec, Estado de Mexico, en este trabajo se estima el alcance de los objetivos sociales de un programa de responsabilidad social administrado por la empresa Cementos Mexicanos (Cemex). Los resultados establecen que, por una parte, los usuarios de este programa construyen viviendas mas grandes, con mas habitaciones y en menos tiempo que sus vecinos no participantes, y por otra, que algunos objetivos sociales del programa aun no han sido alcanzados.
Comparison of laser beam propagation at 785 nm and 1550 nm in fog and haze for optical wireless communications

12 There is currently a misconception among designers and users of free space laser communication (lasercom) equipment that 1550 nm light suffers from less atmospheric attenuation than 785 or 850 nm light in all weather conditions. This misconception is based upon a published equation for atmospheric attenuation as a function of wavelength, which is used frequently in the free-space lasercom literature. In hazy weather (visibility > 2 km), the prediction of less atmospheric attenuation at 1550 nm is most likely true. However, in foggy weather (visibility < 500 m), it appears that the attenuation of laser light is independent of wavelength, ie. 785 nm, 850 nm, and 1550 nm are all attenuated equally by fog. This same wavelength independence is also observed in snow and rain. This observation is based on an extensive literature search, and from full Mie scattering calculations. A modification to the published equation describing the atmospheric attenuation of laser power, which more accurately describes the effects of fog, is offered. This observation of wavelength-independent attenuation in fog is important, because fog, heavy snow, and extreme rain are the only types of weather that are likely to disrupt short (< 500 m) lasercom links. Short lasercom links will be necessary to meet the high availability requirements of the telecommunications industry.
Early epigenetic cancer decisions

Abstract A cancer dogma states that inactivation of oncogene(s) can cause cancer remission, implying that oncogenes are the Achilles’ heel of cancers. This current model of cancer has kept oncogenes firmly in focus as therapeutic targets and is in agreement with the fact that in human cancers all cancerous cells, with independence of the cellular heterogeneity existing within the tumour, carry the same oncogenic genetic lesions. However, recent studies of the interactions between an oncogene and its target cell have shown that oncogenes contribute to cancer development via developmental reprogramming of the epigenome within the target cell. These results provide the first evidence that carcinogenesis can be initiated by epigenetic stem cell reprogramming, and uncover a new role for oncogenes in the origin of cancer. Here we analyse these evidences and discuss how this vision offers new avenues for developing novel anti-cancer interventions.