Miracle-dz/UniFAR-FTUs huggingface dataset:
Internet-Based Programs Incorporating Behavior Change Techniques Are Associated With Increased Smoking Cessation in the General Population: A Systematic Review and Meta-analysis.

Background and aims This study aims to (i) examine the effectiveness of internet-based smoking cessation programs; (ii) describe the number and type of behavior change techniques (BCTs) employed; and (iii) explore whether BCTs included in internet-based smoking cessation programs are related to program effectiveness. Methods MEDLINE, CINAHL, EMBASE, PsycINFO, and CENTRAL databases were searched. Randomized controlled trials were included if they described the study of a smoking cessation program delivered via the internet; included current adult tobacco smokers from the general population; and were written in English. Random effects meta-analyses and meta-regressions were used to examine program effectiveness (pooled odds ratios, by outcome measure, i.e., 7 day point prevalence abstinence [PPA], 30 day PPA, other abstinence measure) in short- and long-term outcomes, and examine the associations between BCT number and type (individual BCTs and BCT domain) and program effectiveness. Results Results from 45 studies were included (n = 65,736). Intervention effectiveness was found in the short term for all outcome measures (OR = 1.29, 95% CI 1.12, 1.50, p = .001), for "prolonged abstinence" (OR = 1.43, 95% CI 1.09, 1.87, p = .009), and "30 day PPA" (OR = 1.75, 95% CI 1.13, 2.72, p = .013). Internet-based programs were effective in the long term for all outcome measures (OR = 1.19, 95% CI = 1.06, 1.35, p = .004) and for "prolonged abstinence" (OR = 1.40, 95% CI 1.19, 1.63, p < .001). On average, interventions used more BCTs than comparison groups (6.6 vs. 3.1, p = .0002). The impact of specific individual BCTs and BCT domains on effectiveness was examined and is reported. Conclusions Internet-based smoking cessation interventions increased the odds of cessation by 29 per cent in the short term and by 19 per cent in the long term. Internet-based smoking cessation intervention development should incorporate BCTs to increase effectiveness. Registration CRD42015014676.
Utility of serum ischemia modified albumin in the early diagnosis of acute coronary syndrome

Context: Coronary artery disease (CAD) is the leading cause of death. Early detection of myocardial ischemia can decrease morbidity and mortality due to CAD. Ischemia modified albumin (IMA) is a newer biomarker for early detection of myocardial ischemia in patients of acute coronary syndrome (ACS) as compared to cardiac troponin T (cTnT). Aims: The aim of this study was to test the utility of IMA, a new biomarker of myocardial ischemia, in the early diagnosis of ACS. Settings and Design: The cross-sectional study group consisted of 101 patients between the age group of 27 and 85 years having ACS and 100 control from a healthy population. Materials and Methods: Blood was collected from all the enrolled patients immediately after admission, and samples were analyzed for cTnT on the fully automated analyzer and IMA on a spectrophotometer. Statistical Analysis Used: Statistical analysis was carried out by calculation of the area under a curve using receiver operating characteristics (ROC) curve analysis for the IMA test in the 101 patients included in the study population. Results: ROC curve area for IMA was 0.89 (95% confidence interval 0.81-0.94). At the cut-off 95 U/ml, sensitivity, and specificity were 85% and 82% and positive predictive value and negative predictive value (NPV) were 88% and 78%, respectively. Conclusions: IMA is a useful ischemic marker for diagnosis of myocardial ischemia due to high sensitivity, and it also facilitates to rule out myocardial ischemia due to high NPV.
Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga

Context and Aims: Impairment in cognition is well-known in patients with major depressive disorder. This study examined the effect of yoga therapy with or without antidepressants and antidepressants alone on certain neuropsychological functions in patients with depression. Correlation between changes in neuropsychological test performance and serum brain-derived neurotrophic factor (BDNF) levels was also explored. Materials and Methods: Antidepressant-naïve/antidepressant-free outpatients with depression received antidepressant medication alone (n = 23) or yoga therapy with (n = 26) or without (n = 16) antidepressants. Depression was assessed using the Hamilton Depression Rating Scale. Neuropsychological tests included digit-span forward and backward, Rey Auditory Verbal Learning Test, and Trail Making Tests (TMT-A and B). These tests were administered before and 3 months after the treatment in patients, and once in healthy comparison subjects (n = 19). Statistical Analysis: Baseline differences were analyzed using independent sample t-test, Chi-square, and one-way ANOVA. Paired t-test was used to analyze the change from baseline to follow-up. Pearson's correlation was used to explore the association of change between 2 variables. Results: Patients had impaired performance on most neuropsychological tests. After 3 months, there was significant improvement – patients' performance was comparable to that of healthy controls on majority of the tests. Significant inverse correlation was observed between increase in BDNF levels and improvement in TMT "A" duration in Yoga-alone group (r = −0.647; P = 0.009). Conclusions: To conclude that, Yoga therapy, alone or in combination with medications, is associated with improved neuropsychological functions and neuroplastic effects in patients with depression.
Conflict among athletes and their coaches: what is the theory and research so far?

ABSTRACT Although social and personal relationships are vital for productivity, health and wellbeing, conflict is inevitable and is likely to cause upset and hurt feelings as well as anxiety and distrust. Despite the potentially central role of interpersonal conflict in sport, researchers have yet to pay concerted attention to exploring the nature of conflict, its antecedents and consequences. Following a thorough literature search 80 research papers were identified, of which only a small number (6) studied interpersonal conflict directly, most captured dysfunctional interpersonal processes such as breakdown of communication. The current review aims to provide a critical summary of the existing literature around the psychological construct of interpersonal conflict, including its antecedents, management strategies and outcomes within the context of coach–athlete relationships as well as other relational contexts in sport. Based on the relevant literature, a framework of interpersonal conflict is proposed, which includes a specific focus on a key dyad within sport coaching – namely the coach–athlete dyad. Future research directions and potential practical implications for sport psychology consultants, coach educators, coaches and athletes as well as other stakeholders are discussed.
Pneumonitis: a serious adverse effect of PD-L1 inhibitors including pembrolizumab

A 70-year-old man presented with breathlessness, cough and fever while receiving pembrolizumab for melanoma. A CT pulmonary angiogram demonstrated small bilateral upper lobe segmental pulmonary emboli with patchy ground-glass opacities and basal perilobular consolidation, in keeping with organising pneumonia. He was treated for community-acquired pneumonia and pulmonary emboli but rapidly deteriorated, with increasing hypoxia and dyspnoea. He was admitted to the intensive care unit for support with continuous positive airway pressure and high flow nasal oxygen. His clinical condition improved once he received high-dose intravenous methylprednisolone to treat pneumonitis. His treatment was continued with a weaning course of high-dose oral steroids, and he was discharged with a persistent oxygen requirement. The patient maintained a requirement for high doses of oral steroids and continued to deteriorate. He was referred to palliative care for symptom management and died a month following hospital discharge, as a result of pneumonitis due to pembrolizumab.
Cost-Effectiveness Analysis of Routine Venous Doppler Ultrasound for Diagnosis of Deep Venous Thrombosis at Admission to Inpatient Rehabilitation

Objective The aims of the study were to identify whether timing of venous thromboembolism diagnosis is associated with differences in patient outcomes and to perform a cost-effectiveness analysis of routine venous Doppler ultrasound at admission to inpatient rehabilitation, taking into account costs associated with prolonged inpatient rehabilitation length of stay, and development of pulmonary embolism. Design This was a retrospective cohort study of 2312 consecutive patient discharges from a single inpatient rehabilitation facility for an 18-mo period. Cost-effectiveness model was built using TreeAge Healthcare Pro. The base case was constructed using probabilities and inpatient rehabilitation length of stay identified from retrospective analysis. Cost of Doppler ultrasound was obtained through the literature, and daily inpatient rehabilitation cost was obtained from the study institution. Results Venous thromboembolism was diagnosed in 6.6% of patients. Asymptomatic patients diagnosed with venous thromboembolism on screening Doppler ultrasound had shorter inpatient rehabilitation length of stay (P = 0.045) and lower rate of pulmonary embolism (P < 0.001) and acute hospital transfer (P = 0.002) than those diagnosed after clinical symptoms developed. Use of routine Doppler ultrasound at inpatient rehabilitation admission was found to be cost-effective, with a total cost of US $20,265 per admission compared with $20,269 per admission without use of Doppler ultrasound at inpatient rehabilitation admission. Conclusions Routine Doppler ultrasound screening for venous thromboembolism at inpatient rehabilitation admission is associated with improved patient outcomes without added cost per admission.
Transfer Behavior of the Weakly Acidic BCS Class II Drug Valsartan from the Stomach to the Small Intestine During Fasted and Fed States

The objective of this study was to investigate the transfer behavior of the weakly acidic BCS class II drug valsartan from the stomach to the small intestine during fasted and fed states. An in vitro transfer model previously introduced by Kostewicz et al. (J Pharm Pharmacol 56(1):43–51, 2004) based on a syringe pump and a USP paddle apparatus was used to determine the concentration profiles of valsartan in the small intestine. Donor phases of simulated gastric fluid during fasted (FaSSGF) and fed (FeSSGF) states were used to predisperse Diovan® tablets (160 mg valsartan). The initial concentrations of valsartan in FaSSGF and FeSSGF were 6.2 and 91.8%, respectively. Valsartan dispersions were then transferred to acceptor phases that simulate intestinal fluid and cover the physiological properties (pH, buffer capacity, and ionic strength) of the gastrointestinal fluid at a flow rate of 2 mL/min. The pH measurements were reported at time intervals corresponded to those of the transfer experiments to investigate the effect of percent dissolved of valsartan in the donor phase on lowering the pH of the acceptor phases. The f2 similarity test was used to compare the concentration profiles in the acceptor phases. In fasted state, the concentration of valsartan in the acceptor phases ranged between 33.1 and 89.4% after 240 min. Whereas in fed state, valsartan was fully dissolved in all acceptor phases within a range of 94.5–104.9% after 240 min. Therefore, the transfer model provides a useful screen for the concentrations of valsartan in the small intestine during fasted and fed states.
[Glycyrrhetinic acid selectively inhibits proliferation of hepatocellular carcinoma cells in vitro].

OBJECTIVE To investigate the selective inhibitory effect of glycyrrhetinic acid on 4 hepatocellular carcinoma (HCC) cells with different proliferation rates and explore the underlying mechanisms. METHODS MTT method was used to detect the proliferation rates of 4 HCC cell lines, namely SMMC-7721, SK-HEP1, HEPG2 and HEP3B. Following treatment of the cells with glycyrrhetinic acid (5, 10, 20, 30, 40, and 60 µmol/L), the cell viability was analyzed using MTT assay and the expressions of total ERK protein, p-ERK protein and topoisomerase IIα were detected using Western blotting. RESULTS Among the 4 cell lines, SMMC-7721 had the lowest and SK-HEP1 had the highest proliferation rate. Treatment with glycyrrhetinic acid for 48 h dose-dependently inhibited the proliferation of all the 4 cell lines in vitro and produced the strongest inhibitory effect in SMMC-7721 cells with the IC50 of 28.04 µmol/L. The proliferation rate of the cells was positively correlated with the expression levels of p-ERK and topoisomerase IIα, which were the lowest in SMMC-7721 cells and the highest in SK-HEP1 cells. Treatment with 50 µmol/L glycyrrhetinic acid significantly down-regulated the expressions of p-ERK and topoisomerase IIα in the 4 HCC cell lines (P<0.05), while 25 µmol/L glycyrrhetinic acid significantly reduced the expression of topoisomerase IIα and p-ERK in SMMC-7721, HEPG2 and HEP3B cells (P<0.05) but not in SK-HEP1 cells. CONCLUSION Glycyrrhetinic acid can inhibit the proliferation of different HCC cells particularly in cells with a low proliferation rate. The inhibitory effect of glycyrrhetinic acid might be mediated by reducing the expressions of topoisomerase IIα and inhibiting the ERK pathway.
Sex‐dependent evolution of life‐history traits following adaptation to climate warming

Summary Thermodynamic processes increase metabolic rate and decrease longevity at high temperatures in ectotherms. However, how sustained long-term increase in temperature affects the evolution of longevity is poorly understood. Stress theory of ageing predicts that increased longevity is positively genetically correlated with resistance to different types of environmental stressors implying that evolutionary trajectories of ageing may be mediated by correlative selection for robust phenotypes under thermal stress. Here, we test this hypothesis by using replicate populations of the seed beetle Callosobruchus maculatus, evolving under two thermal environments: ancestral 30 °C and incremental increase towards novel 36 °C. Beetles evolving under climate warming became larger, more fecund and lived longer than the beetles evolving under 30 °C across both environments. However, the increase in longevity was partly due to parental effects because after two generations of acclimatization it persisted only in males. Our results support the hypothesis that evolution of stress resistance confers increased longevity through positive pleiotropy but demonstrate that such effects can be sex specific. These findings suggest that sex differences can evolve as correlated responses to selection under environmental change.
Impact of Hospital Context on Transitioning Patients From Hospital to Skilled Nursing Facility: A Grounded Theory Study

Background Twenty-five percentage of patients who are transferred from hospital settings to skilled nursing facilities (SNFs) are rehospitalized within 30 days. One significant factor in poorly executed transitions is the discharge process used by hospital providers. Objective The objective of this study was to examine how health care providers in hospitals transition care from hospital to SNF, what actions they took based on their understanding of transitioning care, and what conditions influence provider behavior. Design Qualitative study using grounded dimensional analysis. Participants Purposive sample of 64 hospital providers (15 physicians, 31 registered nurses, 8 health unit coordinators, 6 case managers, 4 hospital administrators) from 3 hospitals in Wisconsin. Approach Open, axial, and selective coding and constant comparative analysis was used to identify variability and complexity across transitional care practices and model construction to explain transitions from hospital to SNF. Key Results Participants described their health care systems as being Integrated or Fragmented. The goal of transition in Integrated Systems was to create a patient-centered approach by soliciting feedback from other disciplines, being accountable for care provided, and bridging care after discharge. In contrast, the goal in Fragmented Systems was to move patients out quickly, resulting in providers working within silos with little thought as to whether or not the next setting could provide for patient care needs. In Fragmented Systems, providers achieved their goal by rushing to complete the discharge plan, ending care at discharge, and limiting access to information postdischarge. Conclusions Whether a hospital system is Integrated or Fragmented impacts the transitional care process. Future research should address system level contextual factors when designing interventions to improve transitional care.
Distributed Algorithms on Exact Personalized PageRank

As one of the most well known graph computation problems, Personalized PageRank is an effective approach for computing the similarity score between two nodes, and it has been widely used in various applications, such as link prediction and recommendation. Due to the high computational cost and space cost of computing the exact Personalized PageRank Vector (PPV), most existing studies compute PPV approximately. In this paper, we propose novel and efficient distributed algorithms that compute PPV exactly based on graph partitioning on a general coordinator-based share-nothing distributed computing platform. Our algorithms takes three aspects into account: the load balance, the communication cost, and the computation cost of each machine. The proposed algorithms only require one time of communication between each machine and the coordinator at query time. The communication cost is bounded, and the work load on each machine is balanced. Comprehensive experiments conducted on five real datasets demonstrate the efficiency and the scalability of our proposed methods.
Nonequilibrium dissipation in living oocytes

Living organisms are inherently out-of-equilibrium systems. We employ recent developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy dissipated by such dynamics. Our model includes complex rheological effects and nonequilibrium stochastic forces. By performing active microrheology and tracking micron-sized vesicles in the cytoplasm of living oocytes, we provide unprecedented measurements of the spectrum of dissipated energy. We show that our model is fully consistent with the experimental data, and we use it to offer predictions for the injection and dissipation energy scales involved in active fluctuations.
Two-Stage Frequency Recognition Method Based on Correlated Component Analysis for SSVEP-Based BCI

A canonical correlation analysis (CCA) is a state-of-the-art method for frequency recognition in steady-state visual evoked potential (SSVEP)-based brain–computer interface (BCI) systems. Various extended methods have been developed, and among such methods, a combination method of CCA and individual-template-based CCA has achieved the best performance. However, the CCA requires the canonical vectors to be orthogonal, which may not be a reasonable assumption for the EEG analysis. In this paper, we propose using the correlated component analysis (CORRCA) rather than CCA to implement frequency recognition. CORRCA can relax the constraint of canonical vectors in CCA and generate the same projection vector for two multichannel EEG signals. Furthermore, we propose a two-stage method based on the basic CORRCA method (termed TSCORRCA). Evaluated on a benchmark data set of 35 subjects, the experimental results demonstrate that CORRCA significantly outperformed CCA, and TSCORRCA obtained the best performance among the compared methods. This paper demonstrates that CORRCA-based methods have a great potential for implementing high-performance SSVEP-based BCI systems.
Investigating the Strain, Temperature and Humidity Sensitivity of a Multimode Graded-Index Perfluorinated Polymer Optical Fiber with Bragg Grating

In this work we investigate the strain, temperature and humidity sensitivity of a Fiber Bragg Grating (FBG) inscribed in a near infrared low-loss multimode perfluorinated polymer optical fiber based on cyclic transparent optical polymer (CYTOP). For this purpose, FBGs were inscribed into the multimode CYTOP fiber with a core diameter of 50 µm by using a krypton fluoride (KrF) excimer laser and the phase mask method. The evolution of the reflection spectrum of the FBG detected with a multimode interrogation technique revealed a single reflection peak with a full width at half maximum (FHWM) bandwidth of about 9 nm. Furthermore, the spectral envelope of the single FBG reflection peak can be optimized depending on the KrF excimer laser irradiation time. A linear shift of the Bragg wavelength due to applied strain, temperature and humidity was measured. Furthermore, depending on irradiation time of the KrF excimer laser, both the failure strain and strain sensitivity of the multimode fiber with FBG can be controlled. The inherent low light attenuation in the near infrared wavelength range (telecommunication window) of the multimode CYTOP fiber and the single FBG reflection peak when applying the multimode interrogation set-up will allow for new applications in the area of telecommunication and optical sensing.
Voter Turnout and the Dynamics of Electoral Competition in Established Democracies since 1945

Figures Tables Preface The authors Introduction 1. Confronting the puzzles of voter turnout 2. A new approach to the calculus of voting 3. The role of generational replacement in turnout change 4. Rational responses to electoral competition 5. Explaining turnout change in 22 countries 6. Electoral competition and the individual citizen 7. Understanding turnout decline 8. The turnout puzzles revisited Appendices: A. The surveys employed in this book B. Aggregate data for established democracies, 1945-9 C. Supplementary findings Bibliography Author index Subject index.
Signal modeling of BC-GPPM for WBAN communication based on IEEE 802.15.6

In this paper, we propose signal-modeling of the block-coded group pulse position modulation (BC-GPPM) for the wireless body area network (WBAN). The BC-GPPM is one of modulation methods for the WBAN application taking the technical requirements such as data-rate scalability, low complexity and low-power. This paper describes concept of WBAN non-coherent standard related to BC-GPPM and proposes a BC-GPPM signal-modeling derived from the conventional pulse position modulation (PPM).