Miracle-dz/UniFAR-FTUs huggingface dataset:
Lactiplantibacillus plantarum N-1 improves autism-like behavior and gut microbiota in mouse

Introduction The gut-brain axis has been widely recognized in autism spectrum disorder (ASD), and probiotics are considered to potentially benefit the rescuing of autism-like behaviors. As a probiotic strain, Lactiplantibacillus plantarumN-1(LPN-1) was utilized to investigate its effects on gut microbiota and autism-like behaviors in ASD mice constructed by maternal immune activation (MIA). Methods Adult offspring of MIA mice were given LPN-1 at the dosage of 2 × 109 CFU/g for 4 weeks before subject to the behavior and gut microbiota evaluation. Results The behavioral tests showed that LPN-1 intervention was able to rescue autism-like behaviors in mice, including anxiety and depression. In which the LPN-1 treatment group increased the time spent interacting with strangers in the three-chamber test, their activity time and distance in the central area increased in the open field test, and their immobility time decreased when hanging their tails. Moreover, the supplementation of LPN-1 reversed the intestinal flora structure of ASD mice by enhancing the relative abundance of the pivotal microorganisms of Allobaculum and Oscillospira, while reducing those harmful ones like Sutterella at the genus level. Discussion These results suggested that LPN-1 supplementation may improve autism-like behaviors, possibly via regulating the gut microbiota.
A REVIEW ON AUTHENTICATION AND PRIVACY PROTECTION SCHEMES IN VEHICULAR AD HOC NETWORKS (VANETS)

Vehicular ad hoc networks (VANETs) is a sort of mobile ad hoc network (MANET) that is designed based on moving vehicles, which are referred to as nodes. The nodes communicate with one another wirelessly, without the need for a network infrastructure that physically connects them. Once the network design has changed, nodes are free to migrate in whatever direction they want as long as the nodes are available to move in that direction. As a result, each node acts as a router, sending traffic to the nodes to which it has been directed. VANET’ popularity however brings with it a variety of issues, including security, routing, and data dissemination. Many solutions have already been presented by different researchers to address these issues, but due tothe constant emergence of new threats and attacks, privacy of users must be prioritized above all in VANET. Consequently, a review of authentication, privacy and security solutions presented in different researches have been discussed in this paper, as well as the security services they have studied which were centered towards Authentication, Confidentiality, Availability, and Integrity. In this paper, 10 most relevant schemes were analysed and the result shows that privacy challenges and high computation overhead which causes transmission delays and adds a difficult verification process to VANET communications was the major challenge affecting the VANETs.
Erosion of metal cathodes by arcs and breakdowns in vacuum

The formation of erosion structures on metal cathodes by arcs and breakdown in UHV was studied experimentally by FEM and SEM and theoretically by a simple model. Nanosecond high-voltage breakdowns and quasi-stationary arcs had analogous effects on the production of surface craters. The existence of sharp micropoints could be proved directly by SEM. In accordance with the experiments the theory shows three distinct stages of crater formation on a nanosecond time scale: initially micropoints explode without strong erosion, then melting occurs with pronounced smoothing of the surface and finally craters are formed by the action of ion pressure. The latter process is connected with the production of a few sharp micropoints at crater boundaries, and of numerous droplets. The results presented here support the non-stationary model of arc cathode spots and the field-emission model of vacuum breakdown.
Climatology of Lake-Effect Precipitation Events over Lake Tahoe and Pyramid Lake

AbstractThe frequency, timing, and environmental conditions of lake-effect (LE) precipitation over Lake Tahoe and Pyramid Lake in northern California and western Nevada were examined for the 14 winters (September–March) from 1996/97 through 2009/10. Weather Surveillance Radar-1988 Doppler (WSR-88D) data from Reno, Nevada (KRGX), were used to identify 62 LE events. LE precipitation occurred as single bands extending downwind from overlake areas, and as isolated regions of overlake precipitation with little or no extension over land. Mesoscale vortices were also identified during both Lake Tahoe and Pyramid Lake LE events. An average of 4.4 LE events occurred each winter in the Lake Tahoe and Pyramid Lake region, with events occurring most frequently in October. LE events had an average duration of 6.3 h, approximately half the duration of LE events observed over Lake Champlain, the New York State Finger Lakes, or the Great Salt Lake. The observed conditions during LE events in the Lake Tahoe and Pyramid La.
Constructing the Landscape Ecological Security Pattern in the Dawen River Basin in China: A Framework Based on the Circuit Principle

With the rapid development of urbanization, land cover, and land use patterns have greatly changed in China, which has damaged the landscape structure, affected the energy balance and material flow within the system, and reduced the value of ecosystem services. The construction of landscape ecological security patterns could promote species exchange between biological groups and increase material and energy exchange between landscape elements. Few studies have focused on the randomness of species to migration path, thus failing to objectively reflect the process of species migration and diffusion. Therefore, circuit theory was used in this study to better match the random selection of migration paths by species. In this paper, 14 typical mammal species from the Dawen River basin of the lower Yellow River in China were selected as examples, and the conclusions were as follows: (1) The ecological sources of the Dawen River basin were 49, with forest land and lakes as the main sources, and they were crucial to the stability of the regional ecological security pattern. A total of 128 ecological corridors were identified, among which 83 were key corridors and the rest were potential corridors. The key corridors throughout the whole region need priority protection and can be used as a core area for the observation and monitoring of natural resources. (2) Based on the circuit principle, 32 pinch points and 21 barrier points were identified, indicating that regional habitat connectivity must be further improved. (3) Four types of zones were determined, and optimization measures were proposed. (4) On the basis of conceptual protection, the ecological protection network of the Dawen River basin was built to enhance ecological resilience. The landscape ecological security pattern of the Dawen River basin was constructed from the three levels of points, corridors, and areas. Based on the concept of regional ecological security, a resource optimization strategy for ecological security patterns was proposed, which is significant for maintaining the integrity of watershed ecosystems.
Global Diabatic Heating during FGGE SOP-1 and SOP-2

Abstract With the increase in the observations data provided by FGGE and the use of global circulation models with full physics for the data assimilation, it is now becoming feasible to attempt to estimate globally the atmospheric diabatic heating. The thermodynamic equation in isobaric coordinates and the data generated by the FGGE III-b analysis of the Goddard Laboratory for Atmospheres (GLA) are employed to serve this purpose. The results of the present study generally agree with other previous investigations. However, some important difference are also revealed. 1) The diabatic heating obtained in the tropics in the present study is larger than that obtained elsewhere; 2) the relatively large heating over the mountainous areas shown in other studies does not appear; 3) no significant negative values of diabatic heating are found in the polar regions; and 4) unlike other studies cooling is noted over parts of Eurasia in the summer.
Computer simulations of nematic droplets

Abstract Nematic droplets are intimately connected with disclinations, because in nematic droplets, point and line-shaped defects, as well as surface defects, are not generated at random, but inevitably by topological constraints. Thus, droplets provide a good means for investigating nematic defects. There is a growing interest in both topics due to the applications in polymer dispersed liquid crystal devices [1–3], but also in classical display modelling, where nematic defects are to be avoided. Various types of droplets are investigated theoretically with the aid of a previously developed numerical algorithm [4,5], which is based on a dynamic equation for the alignment tensor a μv. The rotational diffusion, the influence of an orienting external field, and the Frank elasticity (in the one-coefficient approximation) are taken into account, but flow processes are neglected. For the application to nematic droplets, a new type of boundary conditions had to be used, which I have called ‘true planar anchoring.
Increased Dietary Intakes of Total Protein, Animal Protein and White Meat Protein Were Associated with Reduced Bone Loss—A Prospective Analysis Based on Guangzhou Health and Nutrition Cohort, South China

In this study, we aimed to prospectively investigate the relationships between different types of dietary protein and changes in bone mass in Chinese middle-aged and elderly people. Dietary intakes were evaluated by means of a validated food frequency questionnaire. Bone mineral density (BMD) was measured using a dual-energy bone densitometer at multiple bone sites. Multivariable regression models were applied to investigate the associations of the participants’ dietary intakes of total protein, intakes of protein from various sources, and amino acid intakes with the annualized changes in BMD during a 3-year follow-up. A total of 1987 participants aged 60.3 ± 4.9 years were included in the analyses. Multivariable linear regression results showed that dietary intakes of total protein, animal protein, and protein from white meat were positively correlated with BMD changes, with standardized coefficients (β) of 0.104, 0.073, and 0.074 at the femur neck (p < 0.01) and 0.118, 0.067, and 0.067 at the trochanter (p < 0.01), respectively. With each increase of 0.1g·kg−1·d−1 in animal protein and white meat protein intakes, the BMD losses were reduced by 5.40 and 9.24 mg/cm2 at the femur neck (p < 0.05) and 1.11 and 1.84 mg/cm2 at the trochanter (p < 0.01), respectively. Our prospective data, obtained from Chinese adults, showed that dietary total and animal protein, especially protein from white meat, could significantly reduce bone loss at the femur neck and trochanter.
Flat versus Simulated Mountain Trail Running: A Multidisciplinary Comparison in Well-Trained Runners

This paper compares cardiopulmonary and neuromuscular parameters across three running aerobic speeds in two conditions that differed from a treadmill’s movement: flat condition (FC) and unpredictable roll variations similar to mountain trail running (URV). Twenty well-trained male runners (age 33 ± 8 years, body mass 70.3 ± 6.4 kg, height 1.77 ± 0.06 m, V˙O2max 63.8 ± 7.2 mL·kg−1·min−1) voluntarily participated in the study. Laboratory sessions consisted of a cardiopulmonary incremental ramp test (IRT) and two experimental protocols. Cardiopulmonary parameters, plasma lactate (BLa−), cadence, ground contact time (GT) and RPE values were assessed. We also recorded surface electromyographic (sEMG) signals from eight lower limb muscles, and we calculated, from the sEMG envelope, the amplitude and width of peak muscle activation for each step. Cardiopulmonary parameters were not significantly different between conditions (V˙O2: p = 0.104; BLa−: p = 0.214; HR: p = 0.788). The amplitude (p = 0.271) and width (p = 0.057) of sEMG activation peaks did not change between conditions. The variability of sEMG was significantly affected by conditions; indeed, the coefficient of variation in peak amplitude (p = 0.003) and peak width (p < 0.001) was higher in URV than in FC. Since the specific physical demands of running can differ between surfaces, coaches should resort to the use of non-traditional surfaces, emphasizing specific surface-related motor tasks that are normally observed in natural running environments. Seeing that the variability of muscle activations was affected, further studies are required to better understand the physiological effects induced by systematic surface-specific training and to define how variable-surface activities help injury prevention.
Comprehensive Study of Components and Antimicrobial Properties of Essential Oil Extracted from Carum carvi L. Seeds

Carum carvi L. belongs to the Apiaceae family and is widely used as a vegetable, food spice, preservative, and herbal medicine. This study investigated the impact of essential oil extracted from Carum carvi L. seeds (CEO) on methicillin-resistant Staphylococcus aureus (MRSA) and its possible action mechanism. The dominant chemical components of CEO determined by GC-MS were carvone and limonene. It was observed that CEO had a considerable inhibitory effect against the growth of planktonic bacteria and biofilm in MRSA cells. Untargeted metabolomics based on GC-Q-TOF-MS was used to analyze the possible mechanism of the interaction of MRSA with CEO. It was determined that there were 63 different metabolites based on fold change values greater than 1.5 or less than 1.5, p < 0.05, VIP > 1, which demonstrated amino acid metabolism in MRSA was significantly affected by CEO. In conclusion, CEO has a potent antimicrobial property and has promising potential for use in food and drugs.
A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems

The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies.
Identification of the protonation and oxidation states of the oxygen-evolving complex in the low-dose X-ray crystal structure of photosystem II

In photosystem II (PSII), the O3 and O4 sites of the Mn4CaO5 cluster form hydrogen bonds with D1-His337 and a water molecule (W539), respectively. The low-dose X-ray structure shows that these hydrogen bond distances differ between the two homogeneous monomer units (A and B) [Tanaka et al., J. Am Chem. Soc. 2017, 139, 1718]. We investigated the origin of the differences using a quantum mechanical/molecular mechanical (QM/MM) approach. QM/MM calculations show that the short O4-OW539 hydrogen bond (~2.5 Å) of the B monomer is reproduced when O4 is protonated in the S1 state. The short O3-NεHis337 hydrogen bond of the A monomer is due to the formation of a low-barrier hydrogen bond between O3 and doubly-protonated D1-His337 in the overreduced states (S−1 or S−2). It seems plausible that the oxidation state differs between the two monomer units in the crystal.
Improving driving ability using biofeedback by monitoring the mental situation by RGB camera

In this study, we propose to improve driving ability by biofeedback using an RGB camera by monitoring the mental situation of driver. Driving a car or other vehicle while distracted is extremely dangerous. For example, distracted driving may lead to an accident because of the delay in noticing pedestrians. We believe that it is important for drivers to understand and improve their own distractibility in order to prevent accidents. However, it is difficult to estimate whether a driver is distracted or not, and to improve the situation. Therefore, it is expected to build a method for drivers to understand and improve their own attentiveness. Distractibility is known to be related to sympathetic arousal. In this study, we obtained pulse waves from facial video images using an RGB camera and estimated sympathetic nervous system values from the pulse waves. Biofeedback is provided by optical signals in real time. Biofeedback is performed by presenting color using threshold values based on the estimated sympathetic nerve values. To validate the proposed method, we generated a distracted state by subjecting him to a task and compared the results with and without biofeedback. As a result, it is shown that the amount of time spent in the distracted state with biofeedback was reduced compared to that without biofeedback.
DC-Side Soft-Switching Inverter With Modified Space-Vector Modulation Scheme

Three-phase soft-switching inverters are promising in order to reduce the losses in the switching devices and to reduce the electromagnetic interference produced by severe di/dt and dv/dt, which enables the operation of the inverter at higher switching frequency. This work proposes a dc-side three-phase zero-voltage soft-switching inverter topology that can be sub-categorized under actively clamped resonant dc-link topologies. Moreover, a modified space-vector modulation scheme is proposed, such that all the devices operate under zero-voltage switching condition. Compared to other similar dc-link soft-switching topologies, the proposed topology does not require feedback from the inverter output currents to achieve soft-switching operation. Unlike conventional space-vector modulation techniques, the proposed modified space-vector modulation does not require to turn-on the top and/or the bottom three switches of the two-level inverter at the same time to implement the zero vectors, which allows a reduction of the effective commutating time of the two-level inverter switches by one-third, during a grid voltage cycle. The auxiliary capacitor is only charged to a fraction of the dc-bus voltage. Simulation and experimental results on a 10-kW and 100-kHz switching frequency lab-scale prototype are presented to demonstrate the validity and effectiveness of the proposed zero-voltage switching topology and modulation scheme on reducing the switching losses and electromagnetic interference.
A Multi-Mode Convolutional Neural Network to reconstruct satellite-derived chlorophyll-a time series in the global ocean from physical drivers

Time series of satellite-derived chlorophyll-a concentration (Chl, a proxy of phytoplankton biomass), continuously generated since 1997, are still too short to investigate the low-frequency variability of phytoplankton biomass (e.g. decadal variability). Machine learning models such as Support Vector Regression (SVR) or Multi-Layer Perceptron (MLP) have recently proven to be an alternative approach to mechanistic ones to reconstruct Chl synoptic past time-series before the satellite era from physical predictors. Nevertheless, the relationships between phytoplankton and its physical surrounding environment were implicitly considered homogeneous in space, and training such models on a global scale does not allow one to consider known regional mechanisms. Indeed, the global ocean is commonly partitioned into biogeochemical provinces (BGCPs) into which phytoplankton growth is supposed to be governed by regionally-”homogeneous” processes. The time-evolving nature of those provinces prevents imposing a priori spatially-fixed boundary constraints to restrict the learning phase. Here, we propose to use a multi-mode Convolutional Neural Network (CNN), which can spatially learn and combine different modes, to globally account for interregional variabilities. Each mode is associated with a CNN submodel, standing for a mode-specific response of phytoplankton biomass to the physical forcing. Beyond improving performance reconstruction, we show that the different modes appear regionally consistent with the ocean dynamics and that they may help to get new insights into physical-biogeochemical processes controlling phytoplankton spatio-temporal variability at global scale.
Do Biliary Stents Affect EUS-Guided Tissue Acquisition (EUS-TA) in Solid Pancreatic Lesions Determining Biliary Obstruction? A Literature Review with Meta-Analysis

Simple Summary There is a paucity of evidence assessing the impact of bile duct stenting at the time of EUS-guided tissue sampling, either using fine-needle biopsy (EUS-FNB) or fine-needle aspiration (EUS-FNA) in patients with head of pancreas (HOP) masses. Our main aim was to assess the diagnostic accuracy of endoscopic ultrasound-guided tissue acquisition (EUS-TA) in patients with or without concurrent bile duct stents. Pooled accuracy was not statistically different between both patient subsets. However, we found that, compared to plastic stents, patients with biliary metal stents had a significantly lower yield of EUS-TA for pancreatic head lesions. Abstract There is a paucity of evidence regarding whether biliary stents influence endoscopic ultrasound-guided tissue acquisition using either fine-needle biopsy (EUS-FNB) or fine-needle aspiration (EUS-FNA), among patients with head of pancreas (HOP) lesions. We aimed at assessing the diagnostic accuracy of endoscopic ultrasound-guided tissue sampling in patients with or without bile duct stents. A total of seven studies with 2458 patients were included. The main aim was to assess overall pooled diagnostic accuracy. A pairwise meta-analysis was performed using a random effects model. Outcomes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). We found that pooled accuracy was 85.4% (CI 78.8–91.9) and 88.1% (CI 83.3–92.9) in patients with and without stents, respectively. There was no statistically significant difference between the two (OR 0.74; p = 0.07). Furthermore, patients with metal stents demonstrated a significant difference (OR 0.54, 0.17–0.97; p = 0.05), which was not seen with plastic stents. EUS-FNB showed poorer diagnostic accuracy with concurrent biliary stenting (OR 0.64, 0.43–0.95; p = 0.03); however, the same was not observed with EUS-FNA. Compared to plastic stents, metal biliary stenting further impacted the diagnostic accuracy of EUS-guided tissue acquisition for pancreatic head lesions. There was no difference in the rate of procedure-related adverse events between the stent and no-stent groups.