Miracle-dz/UniFAR-FTUs huggingface dataset:
Report of fertility in a woman with a predominantly 46,XY karyotype in a family with multiple disorders of sexual development.

CONTEXT We report herein a remarkable family in which the mother of a woman with 46,XY complete gonadal dysgenesis was found to have a 46,XY karyotype in peripheral lymphocytes, mosaicism in cultured skin fibroblasts (80% 46,XY and 20% 45,X) and a predominantly 46,XY karyotype in the ovary (93% 46,XY and 6% 45,X). PATIENTS A 46,XY mother who developed as a normal woman underwent spontaneous puberty, reached menarche, menstruated regularly, experienced two unassisted pregnancies, and gave birth to a 46,XY daughter with complete gonadal dysgenesis. RESULTS Evaluation of the Y chromosome in the daughter and both parents revealed that the daughter inherited her Y chromosome from her father. Molecular analysis of the genes SOX9, SF1, DMRT1, DMRT3, TSPYL, BPESC1, DHH, WNT4, SRY, and DAX1 revealed normal male coding sequences in both the mother and daughter. An extensive family pedigree across four generations revealed multiple other family members with ambiguous genitalia and infertility in both phenotypic males and females, and the mode of inheritance of the phenotype was strongly suggestive of X-linkage. CONCLUSIONS The range of phenotypes observed in this unique family suggests that there may be transmission of a mutation in a novel sex-determining gene or in a gene that predisposes to chromosomal mosaicism.
Knowledge management and HRD

Knowledge management is introduced and it is suggested there are two main models, the dominant technology-focused one and a people-oriented one. Neither model recognizes that HRD might play a role in knowledge management; HRD writers have also ignored knowledge management. Knowledge management rests implicitly on a definition of 'knowledge'. Three perspectives on knowledge are outlined, and it is argued that, however knowledge is defined, HRD skills and knowledge will be essential to managing it. The emerging situative perspective provides the strongest theoretical basis for knowledge management's need for HRD.
A glucose sensor hiding in a family of transporters

We have examined the expression and function of a previously undescribed human member (SGLT3/SLC5A4) of the sodium/glucose cotransporter gene family (SLC5) that was first identified by the chromosome 22 genome project. The cDNA was cloned and sequenced, confirming that the gene coded for a 659-residue protein with 70% amino acid identity to the human SGLT1. RT-PCR and Western blotting showed that the gene was transcribed and mRNA was translated in human skeletal muscle and small intestine. Immunofluorescence microscopy indicated that in the small intestine the protein was expressed in cholinergic neurons in the submucosal and myenteric plexuses, but not in enterocytes. In skeletal muscle SGLT3 immunoreactivity colocalized with the nicotinic acetylcholine receptor. Functional studies using the Xenopus laevis oocyte expression system showed that hSGLT3 was incapable of sugar transport, even though SGLT3 was efficiently inserted into the plasma membrane. Electrophysiological assays revealed that glucose caused a specific, phlorizin-sensitive, Na+-dependent depolarization of the membrane potential. Uptake assays under voltage clamp showed that the glucose-induced inward currents were not accompanied by glucose transport. We suggest that SGLT3 is not a Na+/glucose cotransporter but instead a glucose sensor in the plasma membrane of cholinergic neurons, skeletal muscle, and other tissues. This points to an unexpected role of glucose and SLC5 proteins in physiology, and highlights the importance of determining the tissue expression and function of new members of gene families.
THE DEPARTMENT CHAIR AS SPEAKER OF THE HOUSE: SHARED AUTHORITY IN THE COMMUNITY COLLEGE DEPARTMENT

The department chair position is vital to the effective administration of both the academic unit and the entire college. Inherent in the roles and tasks of the individual position is a responsibility for consensus development, which in turn requires the involvement of faculty in decision-making activities. This consensual development dictates that faculty who are specialists in their particular academic disciplines be involved in decisions ranging from admissions and grading to institutional policy formation and cross-disciplinary curricula development. The current study was conducted to examine the perceptions of department chairs in the involvement of faculty in departmental decision-making.
Bipartition Polynomials, the Ising Model, and Domination in Graphs

Abstract This paper introduces a trivariate graph polynomial that is a common generalization of the domination polynomial, the Ising polynomial, the matching polynomial, and the cut polynomial of a graph. This new graph polynomial, called the bipartition polynomial, permits a variety of interesting representations, for instance as a sum ranging over all spanning forests. As a consequence, the bipartition polynomial is a powerful tool for proving properties of other graph polynomials and graph invariants. We apply this approach to show that, analogously to the Tutte polynomial, the Ising polynomial introduced by Andrén and Markström in [3], can be represented as a sum over spanning forests.
Review Paper: Inertial Measurement

Applications of inertial measurement units are extremely diverse, and are expected to see a further increase in number due to current trends in robotics as well as recent advances in Micro Electromechanical sensors (MEMS). The traditional method of inertial measurement has depended on costly, power-intensive, error-prone Inertial Measurement Units (IMUs) that represent a single point of failure. Promising areas of current research include methods for combining multiple redundant sensors, which collectively provide more accurate and more dependable estimates of state, and wholly new IMU layouts that seek to reduce error. New types include: gyro-free, timing, wireless, distributed redundant IMUs, and IMUs that incorporate MEMS components for miniaturization in general. This review paper highlights these new research directions and lays out the design and experimental implementation of a complementary filter for inertial measurement.
Multiple sigma factor genes in Brevibacterium lactofermentum: characterization of sigA and sigB

Four rpoD hybridizing signals have been identified in the chromosome of Brevibacterium lactofermentum. Two rpoD-like genes, sigA and sigB, have been cloned and sequenced, and they encode principal sigma factors of the RNA polymerase. The deduced amino acid sequences of SigA and SigB showed very high similarities to those of Mycobacterium smegmatis MysA and MysB proteins, respectively, and also to those of HrdB proteins from different Streptomyces species. SigA and SigB maintain the conserved motifs of sigma 70-like principal sigma factors. sigB is closely linked to the dtxR gene (encoding a repressor of iron-regulated promoters homologous to the diphtheria toxin repressor from Corynebacterium diphtheriae.
Serveur agent d'information : application à l'information des voyageurs

Dans cet article, nous proposons une architecture de serveur informationnel fondee sur le paradigme multi-agent. Notre proposition s’appuie sur le modele EASI (Environnement comme support Actif des Interactions) qui met en œuvre dans le domaine multi-agent le concept d’ecoute flottante. Il s’agit de permettre aux agents d’evoluer au sein d’un environnement fortement interactionnel. Nous avons applique notre proposition au domaine du transport et plus particulierement de l’information des voyageurs. Nous montrons dans cet article, que notre proposition repond a la problematique du domaine en permettant a chaque voyageur d’organiser sa recherche ainsi que la gestion de la mise a jour des informations pertinentes pour son voyage.
Experimental Evaluation of a Model of Mental Workload

This study was designed to test predictions from a model of mental workload. The model predicts that mental workload grows as perceived distance from a task goal increases and the effective time for action decreases. Decreases in workload can be achieved by actions that bring the task goal into the region of acceptable time/distance constraints for successful resolution. We reported an experiment that tested these assertions using the Timepools performance task. Timepools generates a spatial representation of a shrinking temporal target to assess the effects of path length (i.e., the number of sequential targets to be acquired) and shrink rate (i.e., elapsed time during which the circle is halved in area) on reaction time (RT), movement time (MT), error rate, and the subjective perception of workload. Data from the experiment indicated systematic effects for task-related factors across performance and workload measures. Path length and shrink rate had differential effects on both RT and MT, which were also reflected in the components of the individual workload scales. The results support a general form of the workload model which may help researchers and practitioners in the difficult task of work load prediction
A Specific Dileucine Motif Is Required for the GGA-dependent Entry of Newly Synthesized Insulin-responsive Aminopeptidase into the Insulin-responsive Compartment*

In muscle and adipose cells, the insulin-responsive aminopeptidase (IRAP) is localized to intracellular storage sites and undergoes insulin-dependent redistribution to the cell surface. Following expression, the newly synthesized IRAP protein traffics to the perinuclear insulin-sensitive compartment and acquires insulin sensitivity 6-9 h following biosynthesis. Knockdown of GGA1 by RNA interference prevented IRAP from entering, but not exiting, the insulin-responsive compartment. Mutation of the dileucine motif at positions 76 and 77 (EGFP-IRAP/AA76,77), but not the dileucine motif at positions 53 and 54, resulted in the rapid default of the reporter to the cell surface beginning at 3 h following biosynthesis. Alanine substitution of 9 residues amino- or carboxyl-terminal to LL76,77 did not perturb basal intracellular sequestration or abrogate insulin-stimulated IRAP translocation. Moreover, a dominant interfering GGA mutant (VHS-GAT) potently inhibited insulin-stimulated translocation of EGFP-IRAP/WT but did not block the constitutive exocytotic trafficking of EGFP-IRAP/AA76,77. In addition, the EGFP-IRAP/WT and EGFP-IRAP/AA76,77 constructs occupied morphologically distinct tubulovesicular compartments in the perinuclear region. Taken together, these data indicate that LL76,77 functions during the GGA-dependent sorting of newly made IRAP into the insulin-responsive storage compartment.
Drug-induced long QT syndrome.

This listcan be accessed via the internet:n www.torsades. org n www.qtdrugs. org n www.longqt. orgn www.sads. orgThe prescription of non-cardiac QT-prolonging agents has recently been asso-ciated with a significantly increased risk ofsudden cardiac death in the general popu-lation. The risk of death has been shownto be higher in women and in recentstarters.
A Low Cost Fly back Continuous Conduction Mode Inverter With Lcl Filter For Ac Module Application

This paper presents a method to improve the efficiency by operating the flyback inverter in continuous conduction mode with sliding mode controller for Ac module application. The unfolding type flyback inverter operating in discontinuous conduction mode is the conventional method used for low cost solution for photovoltaic AC application. In this proposed method we have aimed to get an improved efficiency compared with conventional method by using continuous conduction mode flyback inverter with sliding mode controller and the output power quality at rated power level is improved by connecting LCL filter between the inverter and load. Photovoltaic (PV), or solar cells as they are often used for Ac module application, they are used here to convert sunlight into direct-current (DC) electricity.MPPT or Maximum Power Point Tracking algorithm is included in sliding mode controllers used for extracting maximum available power from PV module under certain conditions. Normally, the DC output voltage produced by PV panel is very low which is converted into high AC voltage by using flyback inverter. The main advantage of the flyback inverter is , it does not require any additional circuit to convert the low output voltage of PV panel into high voltage because it has capability to step up the voltage.
Epicardial left atrial appendage clip occlusion also provides the electrical isolation of the left atrial appendage.

OBJECTIVES The exclusion of the left atrial appendage (LAA) has been used to reduce the risk of stroke associated with atrial fibrillation (AF). While LAA exclusion has been associated with a reduced risk of stroke, the effect on the electrical activity of the LAA (a potential source of AF) remains unknown. As such, we sought to demonstrate whether surgical epicardial clip occlusion leads to the electrical isolation of the LAA. METHODS From December 2010 until August 2011, 10 patients with paroxysmal AF underwent off-pump coronary artery bypass surgery with bilateral pulmonary vein isolation and an LAA clip occlusion with a new epicardial clip. Before and after the clip was placed, pacing manoeuvres were performed to assess the electrical exit and entry blocks from the LAA. RESULTS All clips were applied successfully. The mean procedure time for the clip application was 4 ± 1 min. No complications occurred related to clip application. Prior to the pericardial closure, 18 ± 3 min after the clip placement, the LAA stimulation and pacing manoeuvres demonstrated complete electrical isolation of the LAA in all cases. CONCLUSIONS Epicardial LAA clip occlusion leads to the acute electrical isolation of the LAA and may not only provide stroke prevention but also reduce the recurrence of AF.
SELF-COMMAND IN ADAM SMITH'S THEORY OF MORAL SENTIMENTS

Building on an analysis of Adam Smith's enumeration of five classes of passions, we show that self-command in his Theory of Moral Sentiments (TMS) can be modeled as a game whose structure is identical to endogenous quality or reputation models. While acknowledging Smith's views on the evolutive nature of the general rules of morality (as well as the individual's understanding of them), we take the general rules as given. Within the game's framework we show how self-command can be attained in equilibrium solely due to the `internal reputation effect' arising from one's self-interested behavior. Our game-theoretic reinterpretation of TMS sheds new light on the acquisition of self-command and casts Smith as a sophisticated early theorist: he had already dealt with the issue of reputational enforcement, and wrestled with the same tension that has led to the eductive and evolutive approaches to non-cooperative game theory.
R3: A Real-Time Route Recommendation System

Existing route recommendation systems have two main weaknesses. First, they usually recommend the same route for all users and cannot help control traffic jam. Second, they do not take full advantage of real-time traffic to recommend the best routes. To address these two problems, we develop a real-time route recommendation system, called R3, aiming to provide users with the real-time-traffic-aware routes. R3 recommends diverse routes for different users to alleviate the traffic pressure. R3 utilizes historical taxi driving data and real-time traffic data and integrates them together to provide users with real-time route recommendation.
Influencia de los indicios sensoriales en la automatización de los componentes de una tarea de búsqueda categorial

componentes. Palabras clave: Automatizacion, busqueda categorial, indicios sensoriales, entrenamiento Abstract: After confirming (Garcia-Sevilla y Romero, 1991) the facilitation of sensorial cues in automatizing that some components of a categorial search task, now in this experiment the interfering role of inversion technique (change of target stimulus after the sensorial cue) along training is analyzed. The results (with a sample of 60 adults subjects) shows a nega- tive transfer effect at the training start, especially with total incompatibility between sensorial cue and stimulus target. The presence of sensorial cues reduce the amount of resources asigned to categorial search task, producing so a partal automa-
Multiple Fault Attack on PRESENT with a Hardware Trojan Implementation in FPGA

Internet of Things connects lots of small constrained devices to the Internet. As in any other environment, communication security is important and cryptographic algorithms are one of many elements that we use in order to keep messages secure. It is necessary to use algorithms that do not require high computational power, lightweight ciphers are therefore an ideal candidate for this purpose. Since these devices work in various environments, it is necessary to test security of implementations of cryptographic algorithms. In this paper, we explore a possibility of attacking an ultralightweight cipher PRESENT by using a multiple fault attack. Utilizing the Differential Fault Analysis technique, we were able to recover the secret key with two faulty encryptions and an exhaustive search of 216 remaining key bits. Our attack aims at four nibbles in the penultimate round of the cipher, causing faulty output in all nibbles of the output. We also provide a practical attack scenario by exploiting Hardware Trojan (HT) technique for the proposed fault injection in a Xilinx Spartan-6 FPGA.
The vimentin‐GFA protein transition in rat neuroglia cytoskeleton occurs at the time of myelination

Extraction with Triton, a nonionic detergent, is a common procedure to prepare intermediate filament enriched fractions from cells maintained in culture. The Triton‐Insoluble fraction is called a cytoskeletal preparation. Using this procedure, we previously demonstrated that vimentin and glial fibrillary acidic protein (GFA) are major cytoskeletal proteins of neuroglia, in newborn and adult rat brain, respectively. In the present communication we report that the vimentin‐GFA transition in rat brain occurs during the 2nd‐3rd week, ie, at the time of rapid myelination when dividing glioblasts in white matter differentiate into oligodendroglia and interfascicular astrocytes.
NMDA lesions of Ammon's horn and the dentate gyrus disrupt the direct and temporally paced homing displayed by rats exploring a novel environment: evidence for a role of the hippocampus in dead reckoning

Dead reckoning, a form of navigation used to locate a present position and to return to a starting position, is used by rats to return to their home base. The present experiment examined whether dead reckoning is displayed by rats during their first exploratory excursions in a novel environment and also examined whether the behaviour requires the integrity of the cells of the hippocampus. Experimental rats, those with NMDA (N‐methly d‐aspartate) lesions of Ammon's horn and the dentate gyrus, and control rats could leave a cage to explore a large circular table under light and dark conditions. Home base behaviour, use of olfactory cues, and thigmotaxic‐ based navigation were evaluated. Temporal, topographical and kinematic analyses were conducted on the first three exploratory excursions that extended at least halfway across the table. Groups did not differ in numbers of exits from the home base, lingering near the home base, distance travelled, or the use of surface cues as might be exemplified by thigmotaxic and olfactory behaviour. Temporal, topographical and kinematic reconstructions of homing behaviour, however, indicated that control rats, but not hippocampal rats, made direct high velocity return trips to the home base in both the light and the dark. Peak velocity of the trips occurred at the trip midpoint, independent of trip distance, suggesting the movements were preplanned. These results are discussed in relation to the ideas that dead reckoning is used in the homing of exploring rats and that this form of navigation involves the hippocampus.
A low power protocol to broadcast real-time data traffic in a clustered ad hoc network

Energy saving is an extremely important design criteria for mobile ad hoc networks. We present the intra-cluster data-dissemination protocol (Icdp). The Icdp is used to group nodes around a special one, called the cluster leader (CL). The CL centralizes the power management mechanism and acts as a proxy for data transfer between the cluster and the rest of the nodes in the region. When a cluster node enables the power management it goes into "sleep" mode, to minimize power consumption. The CL buffers data frames for power saving stations and delivers them on the stations' request. We periodically distribute the cluster leader role among all the nodes inside the cluster, to not overload a single node. We evaluate the performance benefits of this proposal by simulating the use of our protocol to distribute real-time video in a bounded region.
Efeitos da depressão materna no desenvolvimento neurobiológico e psicológico da criança

Varios estudos recentes tem demonstrado a repercussao da privacao materna no desenvolvimento neurobiologico e psicologico da crianca. A depressao pos-parto, quando persistente, pode favorecer a ocorrencia de situacoes de negligencia e abuso infantil. Este trabalho tem como objetivo revisar estudos publicados a partir de 1988 que demonstrem alteracoes no desenvolvimento neurologico, endocrino, mental e comportamental de criancas cujas maes tiveram depressao pos-parto. A importância do meio ambiente inicial foi revisada em estudos pre-clinicos com mamiferos nao-humanos, demonstrando que, quando ha privacao ou estresse no inicio do desenvolvimento, ocorrem alteracoes persistentes em estruturas encefalicas, em secrecoes neuro-hormonais e na densidade de receptores especificos. Tambem serao descritos alguns aportes teoricos sobre a importância da relacao mae-bebe concordantes com os achados experimentais.
An integrated state- and event-based framework for verifying liveness in supervised systems

Supervisory control theory deals with synthesis of discrete-event supervisory controllers that ensure safe (and nonblocking) behavior of the supervised system. However, the synthesized supervisor comes with no guarantees regarding desired functionality beyond nonblocking behavior. This typically occurs when the control requirements imposed on the system are too strict, or the model of the system needs to be refined. To provide concise and useful feedback to the modeler, we propose an integrated state- and event-based systems engineering framework using state-of-the-art tools: Supremica for supervisor synthesis and mCRL2 for verification. Stating properties in terms of both states and transitions is important in the domain of supervisor synthesis as many control and liveness requirements involve combined state- and event-based specifications. However, many of the available verification tools either focus on state-based or event-based properties. We seek to remedy this situation by providing verification patterns that typically occur in industrial application of supervisory control. We illustrate the framework by revisiting an industrial case study of coordinating maintenance procedures of a high-tech Oce printer, for which we verify the functionality of the solution.
Hacking nondeterminism with induction and coinduction

We introduce bisimulation up to congruence as a technique for proving language equivalence of nondeterministic finite automata. Exploiting this technique, we devise an optimization of the classic algorithm by Hopcroft and Karp. We compare our approach to the recently introduced antichain algorithms and we give concrete examples where we exponentially improve over antichains. Experimental results show significant improvements.