Miracle-dz/UniFAR-FTUs huggingface dataset:
SoK: Making Sense of Censorship Resistance Systems

Abstract An increasing number of countries implement Internet censorship at different scales and for a variety of reasons. Several censorship resistance systems (CRSs) have emerged to help bypass such blocks. The diversity of the censor’s attack landscape has led to an arms race, leading to a dramatic speed of evolution of CRSs. The inherent complexity of CRSs and the breadth of work in this area makes it hard to contextualize the censor’s capabilities and censorship resistance strategies. To address these challenges, we conducted a comprehensive survey of CRSs-deployed tools as well as those discussed in academic literature-to systematize censorship resistance systems by their threat model and corresponding defenses. To this end, we first sketch a comprehensive attack model to set out the censor’s capabilities, coupled with discussion on the scope of censorship, and the dynamics that influence the censor’s decision. Next, we present an evaluation framework to systematize censorship resistance systems by their security, privacy, performance and deployability properties, and show how these systems map to the attack model. We do this for each of the functional phases that we identify for censorship resistance systems: communication establishment, which involves distribution and retrieval of information necessary for a client to join the censorship resistance system; and conversation, where actual exchange of information takes place. Our evaluation leads us to identify gaps in the literature, question the assumptions at play, and explore possible mitigations.
Re-Emerging Field of Lignocellulosic Fiber – Polymer Composites and Ionizing Radiation Technology in their Formulation

ABSTRACT Natural cellulose-based fibers offer low cost, low density composite reinforcement with good strength and stiffness. Because of their annual renewability and biodegradability, natural fibers have materialized as environmentally-friendly alternatives to synthetic fibers in the last two decades. They are replacing synthetic materials in some traditional composites in industrial manufacturing sectors such as automotive, construction, furniture, and other consumer goods. In this work, the use of lignocellulosic fibers in green materials engineering, particularly their application as polymeric composite reinforcement and surface treatment via ionizing radiation are reviewed. Because these cellulose-based materials are intrinsically hydrophilic, they require surface modification to improve their affinity for hydrophobic polymeric matrices, which enhances the strength, durability, and service lifetime of the resulting lignocellulosic fiber-polymer composites. In spite of a long history of using chemical methods in the modification of material surfaces, including the surface of lignocellulosic fibers, recent research leans instead towards application of ionizing radiation. Ionizing radiation methods are considered superior to chemical methods, as they are viewed as clean, energy saving, and environmentally friendly. Recent applications of controlled ionizing radiation doses in the formulation of natural fiber –reinforced polymeric composites resulted in products with enhanced fiber-polymer interfacial bonding without affecting the inner structure of lignocellulosic fibers. These applications are critically reviewed in this contribution.
Characterizing power delivery systems with on/off-chip voltage regulators for many-core processors

Design of power delivery system has great influence on the power management in many-core processor systems. Moving voltage regulators from off-chip to on-chip gains more and more interest in the power delivery system design, because it is able to provide fast voltage scaling and multiple power domains. Previous works are proposed to implement power efficient on-chip regulators. It is also important to analyze the characteristics of the entire power delivery system to explore the tradeoff between the promising properties and costs of employing on-chip regulators. In this work, we develop an analytical model to evaluate important characteristics of the power delivery system, including on-chip/off-chip voltage regulators and the passive on-chip/on-board parasitic. Compared with SPICE simulations, our model achieves a fast system-level evaluation with comparable accuracy. Based on the model, geometric programming is utilized to find the optimal power efficiency of different architectures of power delivery systems under constraints of output voltage stability and area. Experiments show that compared with the conventional architecture using off-chip regulators, the hybrid one using both on-chip and off-chip voltage regulators achieves 1.0% power efficiency improvement and 68% area reduction of voltage regulators on average. We conclude that the hybrid architecture has potential for high power efficiency and small area at heavy workload, but careful account for the overhead of on-chip regulators is needed.
A UI-DSPL Approach for the Development of Context-Adaptable User Interfaces

Unlike adaptive interfaces which use sensors to adapt themselves, adaptable interfaces need the intervention of end users to adapt their different aspects according to user requirements. These requirements are commonly expressed according to the context of use. This latter was defined by the triplet <platform, environment, user> where the platform refers to the physical device and the device software, the environment refers to the physical environment in which the application is used and the user element refers to the user preferences and user profile. In this paper, we define a dynamic software product line (DSPL) approach for the development of a family of context-adaptable user interfaces. The DSPL paradigm exploits the knowledge acquired in software product line engineering to develop systems that can be context-aware, or runtime adaptable. Our approach satisfies a set of contributions which will be validated by implementing and evaluating them according to an illustrative case study.
Potential Audiological and MRI Markers of Tinnitus

Abstract Background: Subjective tinnitus, or ringing sensation in the ear, is a common disorder with no accepted objective diagnostic markers. Purpose: The purpose of this study was to identify possible objective markers of tinnitus by combining audiological and imaging-based techniques. Research Design: Case-control studies. Study Sample: Twenty adults drawn from our audiology clinic served as participants. The tinnitus group consisted of ten participants with chronic bilateral constant tinnitus, and the control group consisted of ten participants with no history of tinnitus. Each participant with tinnitus was closely matched with a control participant on the basis of age, gender, and hearing thresholds. Data Collection and Analyses: Data acquisition focused on systematic administration and evaluation of various audiological tests, including auditory-evoked potentials (AEP) and otoacoustic emissions, and magnetic resonance imaging (MRI) tests. A total of 14 objective test measures (predictors) obtained from audiological and MRI tests were subjected to statistical analyses to identify the best predictors of tinnitus group membership. The least absolute shrinkage and selection operator technique for feature extraction, supplemented by the leave-one-out cross-validation technique, were used to extract the best predictors. This approach provided a conservative model that was highly regularized with its error within 1 standard error of the minimum. Results: The model selected increased frontal cortex (FC) functional MRI activity to pure tones matching their respective tinnitus pitch, and augmented AEP wave N1 amplitude growth in the tinnitus group as the top two predictors of tinnitus group membership. These findings suggest that the amplified responses to acoustic signals and hyperactivity in attention regions of the brain may be a result of overattention among individuals that experience chronic tinnitus. Conclusions: These results suggest that increased functional MRI activity in the FC to sounds and augmented N1 amplitude growth may potentially be the objective diagnostic indicators of tinnitus. However, due to the small sample size and lack of subgroups within the tinnitus population in this study, more research is needed before generalizing these findings.
Multiple Loss-of-Function Mechanisms Contribute to SCN5A-Related Familial Sick Sinus Syndrome

Background To identify molecular mechanisms underlying SCN5A-related sick sinus syndrome (SSS), a rare type of SSS, in parallel experiments we elucidated the electrophysiological properties and the cell surface localization of thirteen human Nav1.5 (hNav1.5) mutant channels previously linked to this disease. Methodology/Principal Findings Mutant hNav1.5 channels expressed by HEK293 cells and Xenopus oocytes were investigated by whole-cell patch clamp and two-microelectrode voltage clamp, respectively. HEK293 cell surface biotinylation experiments quantified the fraction of correctly targeted channel proteins. Our data suggested three distinct mutant channel subtypes: Group 1 mutants (L212P, P1298L, DelF1617, R1632H) gave peak current densities and cell surface targeting indistinguishable from wild-type hNav1.5. Loss-of-function of these mutants resulted from altered channel kinetics, including a negative shift of steady-state inactivation and a reduced voltage dependency of open-state inactivation. Group 2 mutants (E161K, T220I, D1275N) gave significantly reduced whole-cell currents due to impaired cell surface localization (D1275N), altered channel properties at unchanged cell surface localization (T220I), or a combination of both (E161K). Group 3 mutant channels were non-functional, due to an almost complete lack of protein at the plasma membrane (T187I, W1421X, K1578fs/52, R1623X) or a probable gating/permeation defect with normal surface localisation (R878C, G1408R). Conclusions/Significance This study indicates that multiple molecular mechanisms, including gating abnormalities, trafficking defects, or a combination of both, are responsible for SCN5A-related familial SSS.
Co-existing Hepatitis C and Alcoholic Liver Disease: A Diminishing Indication for Liver Transplantation?

Aims To provide an overview of published literature on the interaction of alcohol and hepatitis C virus (HCV) in the accelerated progression of liver disease to cirrhosis as relates to decision-making for the management of the liver transplant candidate and recipient. Methods General PubMed search was employed along with expert input to identify the relevant articles on the topic. The authors also utilized both backward and forward citation review of the relevant articles and reviews to identify articles on identified topic. Results In HCV cases, heavy alcohol use has been associated with more severe fibrosis, but even low rates of use may have deleterious effects. Patients with chronic hepatitis C and alcoholic liver disease can be cured of the HCV-theoretically positively impacting outcome and reducing the need for liver transplantation. Current antiviral therapy achieves virologic cure or sustained viral response (SVR) in over 90% of cases. Antiviral therapy is so effective that most liver transplant candidates or recipients can be cured of HCV either prior to or after transplantation. However, despite successful antiviral therapy, liver disease may progress after SVR due to the effects of ongoing alcohol use. Conclusion Antiviral therapy in patients with HCV plus alcohol should improve pre- and post-transplant outcomes, but providers must remain firm in limiting use of alcohol to avoid progression of liver disease post HCV cure. Short Summary Abusive alcohol use and chronic hepatitis C virus (HCV) commonly co-exist and both need to be addressed in liver disease. With high rates of HCV cure with new therapies, attention needs to turn toward ongoing abusive alcohol patterns that may determinately impact liver health both before and after liver transplant.
A Review of Discharge-Prediction Processes in Acute Care Hospitals

Aims and Objectives: Discharge prediction is designed to streamline inpatient flow and reduce hospital overcrowding without adding capacity. This study's objective was to describe the literature on discharge prediction and assess its usefulness in evaluating the implementation and outcomes of discharge prediction projects. Methods: The authors reviewed the current peer-reviewed and grey literature on discharge prediction projects in acute care hospitals. Project descriptions were analyzed using Donabedian's structure–process–outcome model for evaluating complex healthcare innovations. Results: The review revealed a paucity of literature on the use and effectiveness of discharge prediction. There is high variation in its use and generally poor reporting of both implementation and outcomes. Conclusions: The literature on discharge prediction generally lacks the descriptive detail that would be useful to parties considering or planning a discharge prediction initiative. Further study is required to determine how best to integrate these prediction tools into acute care hospitals.
Clinical Predictors of Malaria, Acute Bacterial Meningitis and Treatment Outcomes among Febrile Children Admitted with Altered Mental Status in Northwestern Tanzania

Background Malaria and acute bacterial meningitis (ABM) are the leading infectious causes of febrile encephalopathy in malaria endemic settings. The clinical distinction of the two conditions is complicated by overlap in clinical features. Objective To determine the clinical predictors for malaria, ABM and treatment outcome in febrile children aged 2 months to 12 years with altered mentation at two tertiary hospitals in Northwestern Tanzania. Methods Prospective study of 103 children to document demographic data and physical examination findings, such as level of consciousness and meningeal irritations. Laboratory results for cerebrospinal fluid, hemoglobin, malaria and HIV were also evaluated. Results Age >60 months and hemoglobin ≤5 g/dl were independent predictors of malaria; (p = 0.013 and 0.004, respectively). HIV infection was the only predictor of meningitis, p = 0.037, and mortality was high if the diagnosis was unconfirmed. Conclusions Children with febrile encephalopathy are more likely to have malaria than ABM if they have severe anemia.
The Use of Smartphones as a Digital Security Blanket: The Influence of Phone Use and Availability on Psychological and Physiological Responses to Social Exclusion

Objective Mobile phones are increasingly becoming a part of the social environment, and when individuals feels excluded during a socially stressful situation, they often retreat to the comfort of their phone to ameliorate the negativity. This study tests whether smartphone presence does, in fact, alter psychological and physiological responses to social stress. Methods Participants (N = 148, 84% female, mean age = 20.4) were subjected to a peer, social-exclusion stressor. Before exclusion, participants were randomized to one of the following three conditions: (1) phone-present with use encouraged, (2) phone-present with use restricted, or (3) no phone access. Saliva samples and self-report data were collected throughout the study to assess salivary alpha amylase (sAA), cortisol, and feelings of exclusion. Results Participants in both phone-present conditions reported lower feelings of exclusion compared with individuals who had no access to their phone (F(2,143) = 5.49, p = . 005). Multilevel modeling of sAA responses revealed that the individuals in the restricted-phone condition had a significantly different quadratic trajectory after the stressor compared with the phone use (υ = −0.12, z = −2.15, p = .032), and no-phone conditions (υ = −0.14, z = −2.64, p = .008). Specifically, those in the restricted-phone condition showed a decrease in sAA after exclusion, those in the no-phone condition showed a gradual increase, and phone users exhibited little change. Cortisol responses to the stressor did not vary by condition. Conclusions Taken together, these results suggest that the mere presence of a phone (and not necessarily phone use) can buffer against the negative experience and effects of social exclusion.
Antisuicidal Response Following Ketamine Infusion Is Associated With Decreased Nighttime Wakefulness in Major Depressive Disorder and Bipolar Disorder.

OBJECTIVE Insomnia and disrupted sleep are associated with increased risk of suicide. The N-methyl-d-aspartate antagonist ketamine has been associated with reduced suicidal thoughts, but the mechanism of action is unknown. This study sought to evaluate differences in nocturnal wakefulness in depressed individuals who did and did not have an antisuicidal response to ketamine. METHODS Thirty-four participants with baseline suicidal ideation diagnosed with either DSM-IV major depressive disorder (n = 23) or bipolar depression (n = 11) between 2006 and 2013 completed nighttime electroencephalography (EEG) the night before and the night after a single ketamine infusion (0.5 mg/kg over 40 minutes). Suicidal ideation was assessed at baseline and the morning after ketamine infusion via several measures, including the Hamilton Depression Rating Scale suicide item, the suicide item of the Montgomery-Asberg Depression Rating Scale, and the first 5 items of the Scale for Suicide Ideation. A generalized linear mixed model evaluated differences in nocturnal wakefulness, as verified by EEG, between those who had an antisuicidal response to ketamine and those who did not, controlling for baseline nocturnal wakefulness. Results were also compared to the sleep of healthy controls (n = 22). RESULTS After analyses adjusted for baseline sleep, participants with an antisuicidal response to ketamine showed significantly reduced nocturnal wakefulness the night after ketamine infusion compared to those without an antisuicidal response (F₁,₂₂ = 5.04, P = .04). Level of nocturnal wakefulness after antisuicidal response to ketamine did not differ significantly from nocturnal wakefulness in the control sample but did differ at a trend level (F₁,₄₀ = 3.15, P = .08). CONCLUSIONS Reductions in wakefulness following ketamine may point to a biological mechanism underlying the effect of ketamine on suicidal ideation. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT00088699.
Bias Due to Methods of Parasite Detection When Estimating Prevalence of Infection of Triatoma infestans by Trypanosoma cruzi

ABSTRACT: The study aimed to quantify the bias from parasite detection methods in the estimation of the prevalence of infection of Triatoma infestans by Trypanosoma cruzi, the agent of Chagas disease. Three common protocols that detect T. cruzi in a sample of 640 wild-caught T. infestans were compared: (1) the microscopic observation of insect fecal droplets, (2) a PCR protocol targeting mini-exon genes of T. cruzi (MeM-PCR), and (3) a PCR protocol targeting a satellite repeated unit of the parasite. Agreement among protocols was computed using Krippendorff Kα. The sensitivity (Se) and specificity (Sp) of each protocol was estimated using latent class models. The PCR protocols were more sensitive (Se > 0.97) than microscopy (Se = 0.53) giving a prevalence of infection of 17-18%, twice as high as microscopy. Microscopy may not be as specific as PCR if Trypanosomatid-like organisms make up a high proportion of the sample. For small T. infestans, microscopy is not efficient, giving a prevalence of 1.5% when PCR techniques gave 10.7%. The PCR techniques were in agreement (Kα = 0.94) but not with microscopy (Kα never significant with both PCR techniques). Among the PCR protocols, the MeM-PCR was the most efficient (Se=1; Sp=1).
Antioxidant Properties of Probiotic Bacteria

Oxidative stress defines a condition in which the prooxidant–antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ viability. Probiotics have been known for many beneficial health effects, and the consumption of probiotics alone or in food shows that strain-specific probiotics can present antioxidant activity and reduce damages caused by oxidation. However, the oxidation-resistant ability of probiotics, especially the underling mechanisms, is not properly understood. In this view, there is interest to figure out the antioxidant property of probiotics and summarize the mode of action of probiotic bacteria in antioxidation. Therefore, in the present paper, the antioxidant mechanisms of probiotics have been reviewed in terms of their ability to improve the antioxidant system and their ability to decrease radical generation. Since in recent years, oxidative stress has been associated with an altered gut microbiota, the effects of probiotics on intestinal flora composition are also elaborated.
Progression towards smoking cessation: Qualitative analysis of successful, unsuccessful, and never quitters

ABSTRACT Background: Understanding how people transition between phases of not making a quit attempt to stopping smoking successfully is important in order to optimize interventions. This study aimed to explore differences in attitudes towards smoking and quitting among smokers and ex-smokers. Methods: Adult (age 18 and over) successful (n = 8), unsuccessful (n = 8) and never quitters (n = 7) were recruited through stop-smoking services in England. Semi-structured interviews were conducted and data were analysed using framework analysis. Results: Seven themes (starting to smoke, positive appraisal of smoking, responsibility for past/current smoking, negative effects of smoking, reasons to quit, process of quitting, and identity) were identified in all groups. Sub-group differences were explored and used to derive six typologies with descriptive characteristics: committed smokers, aware smokers, forced attempters, struggling attempters, pragmatic ex-smokers, and committed non-smokers. Using these typologies and the smallest number of differentiating factors between them (awareness of negative effects, motivation to stop and acceptance of responsibility), a parsimonious model of progression towards smoking cessation was developed. Conclusions: Awareness of negative effects, motivation and, crucially, a sense of commitment for taking responsibility to take actions towards behavior change may be important for whether smokers attempt to quit and progress to a successful quit attempt.
Dense-HOG-based drift-reduced 3D face tracking for infant pain monitoring

This paper presents a new algorithm for 3D face tracking intended for clinical infant pain monitoring. The algorithm uses a cylinder head model and 3D head pose recovery by alignment of dynamically extracted templates based on dense-HOG features. The algorithm includes extensions for drift reduction, using re-registration in combination with multi-pose state estimation by means of a square-root unscented Kalman filter. The paper reports experimental results on videos of moving infants in hospital who are relaxed or in pain. Results show good tracking behavior for poses up to 50 degrees from upright-frontal. In terms of eye location error relative to inter-ocular distance, the mean tracking error is below 9%.