Miracle-dz/UniFAR-FTUs huggingface dataset:
UNIVERSIDADE TECNOLÓGICA FEDERAL DO PARANÁ COORDENAÇÃO DE TECNOLOGIA E ENGENHARIA DE ALIMENTOS CURSO SUPERIOR DE TECNOLOGIA DE ALIMENTOS CAMPUS CAMPO MOURÃO - PARANÁ

The objective of this study was to evaluate the physicochemical and antioxidant activity of propolis extract microencapsulated by spray dextrins, maltodextrins and gum arabic. The samples were evaluated for moisture, water activity, density, hygroscopicity, encapsulation efficiency, solubility, stability of phenolic compounds and flavonoids during storage and antioxidant activity. Propolis microencapsulated with maltodextrin common value showed lower hygroscopicity, greater retention of phenolic compounds and higher drying loss of phenolic compounds during the storage time. Propolis microencapsulated with acetylated maltodextrin showed lower moisture content, water activity, density, suffered the smallest losses of phenolics and greater stability during 60 days of storage. Microencapsulation of propolis extract proved to be a very effective method in the retention of the active ingredients in the same.
Robust Continuous System Integration for Critical Deep-Sea Robot Operations Using Knowledge-Enabled Simulation in the Loop

Deep-sea robot operations demand a high level of safety, efficiency and reliability. As a consequence, measures within the development stage have to be implemented to extensively evaluate and benchmark system components ranging from data acquisition, perception and localization to control. We present an approach based on high-fidelity simulation that embeds spatial and environmental conditions from recorded real-world data. This simulation in the loop (SIL) methodology allows for mitigating the discrepancy between simulation and real-world conditions, e.g. regarding sensor noise. As a result, this work provides a platform to thoroughly investigate and benchmark behaviors of system components concurrently under real and simulated conditions. The conducted evaluation shows the benefit of the proposed work in tasks related to perception and self-localization under changing spatial and environmental conditions.
Auditory Proprioceptive Integration: Effects of Real-Time Kinematic Auditory Feedback on Knee Proprioception

The purpose of the study was to assess the influence of real-time auditory feedback on knee proprioception. Thirty healthy participants were randomly allocated to control (n = 15), and experimental group I (15). The participants performed an active knee-repositioning task using their dominant leg, with/without additional real-time auditory feedback where the frequency was mapped in a convergent manner to two different target angles (40 and 75°). Statistical analysis revealed significant enhancement in knee re-positioning accuracy for the constant and absolute error with real-time auditory feedback, within and across the groups. Besides this convergent condition, we established a second divergent condition. Here, a step-wise transposition of frequency was performed to explore whether a systematic tuning between auditory-proprioceptive repositioning exists. No significant effects were identified in this divergent auditory feedback condition. An additional experimental group II (n = 20) was further included. Here, we investigated the influence of a larger magnitude and directional change of step-wise transposition of the frequency. In a first step, results confirm the findings of experiment I. Moreover, significant effects on knee auditory-proprioception repositioning were evident when divergent auditory feedback was applied. During the step-wise transposition participants showed systematic modulation of knee movements in the opposite direction of transposition. We confirm that knee re-positioning accuracy can be enhanced with concurrent application of real-time auditory feedback and that knee re-positioning can modulated in a goal-directed manner with step-wise transposition of frequency. Clinical implications are discussed with respect to joint position sense in rehabilitation settings.
Perovskite-based solar cells: impact of morphology and device architecture on device performance

Organic–inorganic metal halide perovskites have recently shown great potential for application in solar cells with excitingly high performances with an up-to-date NREL-certified record efficiency of 20.1%. This family of materials has demonstrated considerable prospects in achieving efficiencies comparable to or even better than those of thin film solar cells. The remarkable performances thus far seem not to be limited to any specific device architecture. Both mesoscopic and planar cells showed good device performance and this eventually leads to the inevitable comparison between both architectures. Regardless of device architecture, device performance is highly dependent on the film morphology. The factors influencing the film morphology such as the deposition method, material composition, additives and film treatment will be discussed extensively in this review. The key to obtaining good-quality film morphology and hence performance is to essentially lower the energy barrier for nucleation and to promote uniform growth of the perovskite crystals. A comparison of the material selection for various layers as well as their corresponding impact on the perovskite film and device behavior in both device architectures will be presented.
Molecular aspects of uterine diseases in dogs

Uterine diseases are common in dogs, particularly in countries where elective spaying is not usually performed. The associated clinical illnesses may be of varying degree ranging from merely decreased fertility to a critical pyometra requiring intensive care to survive. The diagnosis of some uterine diseases is generally uncomplicated, such as in a classic pyometra presenting with enlarged, fluid-filled uterus, purulent vaginal discharge and characteristic signs of illness or in other disorders associated with uterine enlargement. However, it can be more puzzling in diseases with normal uterine size and very mild or obscure clinical signs. It is important to recognize the uterine diseases early because of the risk of potentially life-threatening complications such as sepsis developing if treatment is delayed in cases where bacterial infection is present. In breeding bitches, an early diagnosis, that is when the disease has not developed extensively, will increase the possibility of non-surgical treatment options without increased risk and thereby also increasing chances of maintained fertility. Early diagnosis and treatment initiation are thus favourable for complete recovery, also in less severe uterine diseases and those without infection. Molecular markers are molecules in biological samples that can be measured for diagnostic purposes, outcome prediction, and for gaining more information about different physiological and pathological conditions. Examples of commonly evaluated markers include laboratory variables analysed in blood, urine, cytological or tissue biopsy samples. Regarding the genetic pre-disposition for different uterine diseases in dogs, information is lacking. Recently, the global gene expression in uterine tissue in dogs has been investigated more closely, and newly developed technologies provide excellent opportunities for identifying molecular markers worth exploring further. The focus of this review article is to highlight findings on markers relevant for diagnosis, prediction of prognosis and treatment outcome in the most common uterine diseases in dogs.
The p38 signaling pathway mediates quiescence of glioma stem cells by regulating epidermal growth factor receptor trafficking

EGFR pathway is upregulated in malignant gliomas, and its downstream signaling is important for self-renewal of glioma cancer stem-like cells (GSC). p38 mitogen-activated protein kinase (MAPK) signaling, a stress-activated signaling cascade with suppressive and permissive effects on tumorigenesis, can promote internalization and ubiquitin ligase mediated degradation of EGFR. In this study, we investigated the role of p38 MAPK signaling on the self-renewal of GSCs with the hypothesis that inhibition may lead to enhanced self-renewal capacity by retention of EGFR. Inhibition of p38 MAPK pathway led to increase in EGFR expression but surprisingly, reduced proliferation. Additional functional evaluation revealed that p38 inhibition was associated with decrease in cell death and maintenance of undifferentiated state. Further probing the effect of p38 inhibition demonstrated attenuation of EGFR downstream signaling activity in spite of prolonged surface expression of the receptor. In vitro observations were confirmed in xenograft in vivo experiments. These data suggest that p38 MAPK control of EGFR signaling activity may alter GSC cell cycle state by regulating quiescence and passage into transit amplifying state.
Mining topic-level opinion influence in microblog

This paper proposes a Topic-Level Opinion Influence Model (TOIM) that simultaneously incorporates topic factor, user opinions and social influence in a unified probabilistic model with two stages learning processes. In the first stage, topic factor and user influence are integrated to generate users' influential relationship based on different topics; in the second stage, users' historical messages and social interaction records are leveraged by TOIM to construct their historical opinions and neighbors' opinion influence through a statistical learning process, which can be further utilized to predict users' future opinions on some specific topics. We evaluate our TOIM on a large-scaled dataset from Tencent Weibo, one of the largest microbloggings website in China. The experimental results show that TOIM can better predict users' opinion than other baseline methods.
Predictive Factors for Premature Discontinuation of Docetaxel-Based Systemic Chemotherapy in Men With Castration-Resistant Prostate Cancer

Purpose The objective was to determine predictive factors for premature discontinuation of docetaxel-based systemic chemotherapy in men with castration-resistant prostate cancer (CRPC). Materials and Methods We retrospectively reviewed the medical records of men who were treated with docetaxel-based systemic chemotherapy for CRPC in a single institution between May 2005 and April 2010. After being screened, 30 patients fit the eligibility criteria for inclusion in this study. Group 1 included 12 patients who were treated with five or fewer cycles of docetaxel chemotherapy for CRPC, and group 2 included 18 patients who were treated with six or more cycles of docetaxel chemotherapy for CRPC. The treatment consisted of 5 mg prednisolone twice daily and 75 mg/m2 docetaxel once every 3 weeks. Results The median age was 72 years, and the median Eastern Cooperative Oncology Group (ECOG) performance status was 0. The median baseline prostate-specific antigen (PSA) level was 33.8 ng/mL. The median cycle of docetaxel-based chemotherapy was 5.8. Of 30 patients, 13 patients (48.2%) had a decline in PSA of >50% from baseline; 3 of 22 patients (13.6%) with measurable disease had achieved partial response on imaging. No differences in age, ECOG performance status, hemoglobin, serum creatinine, or PSA response were observed between the two groups. Body mass index was significantly lower (p=0.034) in group 1 (21.8 kg/m2) than in group 2 (23.6 kg/m2). Group 1 included more patients with prior systemic chemotherapy (p=0.039), and group 1 had a shorter overall survival rate (p=0.039). Conclusions Premature discontinuation of docetaxel-based systemic chemotherapy is associated with lower body mass index and prior systemic chemotherapy. Premature discontinuation of docetaxel-based chemotherapy is associated with a shorter overall survival rate.
Postpartum unconscious dynamics emerging from the Lüscher color test in Ethiopian women

Abstract The aim of this study was to explore the feasibility of the Lüscher color test (LCT), a psychological instrument based on theory that colors are selected in unconscious way and that the color sensory perception of color is objective and universal. The research has involved 24 Ethiopian women, which delivered at the Getche Health Center in Gurage. It seemed to be relevant for the majority of Ethiopian women identify the rejected color (58.66%), the gray, than the favorite color, the yellow 33.33%). The yellow color suggests that they better express their personality in a physical context, while the gray color indicates that they want to live this experience intensely. This exploratory work lays the foundations for further studies in disadvantaged women, both in developing low-income Countries as well as in industrialized Countries characterized by an high level of emigration, and for clinical applications by the complete LCT version.
Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis

It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 might be associated with the susceptibility to sports-related tendon and ligament injuries such as ACL injuries, Achilles tendon injuries, shoulder dislocations and tennis elbow. But the data from different studies have been conflicting. Here we attempted to systematically summarize and clarify the association between the SNP and sports-related tendon and ligament injuries risk. Six eligible studies including 933 cases and 1,381 controls were acquired from PubMed, Web Of Science and Cochrane library databases. Significant association was identified in homozygote model (TT versus GG: OR=0.17, 95%CI 0.08-0.35, PH=0.00) and recessive model (TT versus GT/GG: OR=0.21, 95%CI 0.10-0.44, PH=0.00). Our results indicated that COL1A1 rs1800012 polymorphism may be associated with the reduced risk of sports-related tendon or ligament injuries, especially in ACL injuries, and that rare TT may played as a protective role.
Soft Tissue Mineralization in Captive 2-Toed Sloths

Soft tissue mineralization was diagnosed in 19 captive 2-toed sloths (Choloepus didactylus and Choloepus hoffmanni) ranging from 2 months to 41 years of age. Gross mineralization was evident at necropsy in 6 of 19 sloths and was prominent in the aorta and arteries. Histologically, 11 sloths had arterial mineralization, including mural osseous and chondroid metaplasia and smooth muscle hyperplasia consistent with arteriosclerosis. Visceral mineralization most commonly involved the gastric mucosa (17 sloths), kidneys (17 sloths), and lungs (8 sloths). Eleven sloths ranging in age from 5 to 41 years old had moderate to severe renal disease, which may be an important underlying cause of soft tissue mineralization in adult sloths. However, 5 sloths (juveniles and adults) had severe soft tissue mineralization with histologically normal kidneys or only mild interstitial inflammation or fibrosis, suggesting other causes of calcium and phosphorus imbalance. Degenerative cardiac disease was a common finding in 10 sloths with vascular mineralization and varied from mild to severe with fibrosis and acute noninflammatory myocardial necrosis. Although the prevalence of cardiac disease in adult sloths has not been documented, disease may be exacerbated by hypertension from degenerative arteriosclerosis as noted in this study group. Although renal disease likely contributed substantially to mineralization of tissues in most sloths in this study, nutritional causes of soft tissue mineralization—such as imbalances in dietary vitamin D or calcium and phosphorus—may be an important contributing factor.
Mortality Rates After the First Diagnosis of Psychotic Disorder in Adolescents and Young Adults

Importance Individuals with psychotic disorders have increased mortality, and recent research suggests a marked increase shortly after diagnosis. Objective To use population-based data to examine overall and cause-specific mortality after first diagnosis of a psychotic disorder. Design, Setting, and Participants This cohort study used records from 5 integrated health systems that serve more than 8 million members in 5 states. Members aged 16 through 30 years who received a first lifetime diagnosis of a psychotic disorder from September 30, 2009, through September 30, 2015, and 2 comparison groups matched for age, sex, health system, and year of diagnosis were selected from all members making an outpatient visit (general outpatient group) and from all receiving a first diagnosis of unipolar depression (unipolar depression group). Exposures First recorded diagnosis of schizophrenia, schizoaffective disorder, mood disorder with psychotic symptoms, or other psychotic disorder in any outpatient, emergency department, or inpatient setting. Main Outcomes and Measures Death within 3 years after the index diagnosis or visit date, ascertained from health system electronic health records, insurance claims, and state mortality records. Results A total of 11 713 members with first diagnosis of a psychotic disorder (6976 [59.6%] men and 4737 [40.4%] women; 2368 [20.2%] aged 16-17 and 9345 [79.8%] aged 18-30 years) were matched to 35 576 outpatient service users and 23 415 members with a first diagnosis of unipolar depression. During the year after the first diagnosis, all-cause mortality was 54.6 (95% CI, 41.3-68.0) per 10 000 in the psychotic disorder group compared with 20.5 (95% CI, 14.7-26.3) per 10 000 in the unipolar depression group and 6.7 (95% CI, 4.0-9.4) per 10 000 in the general outpatient group. After adjustment for race, ethnicity, and preexisting chronic medical conditions, the relative hazard of death in the psychotic disorder group compared with the general outpatient group was 34.93 (95% CI, 8.19-149.10) for self-inflicted injury or poisoning and 4.67 (95% CI, 2.01-10.86) for other type of injury or poisoning. Risk of death due to heart disease or diabetes did not differ significantly between the psychotic disorder and the general outpatient groups (hazard ratio, 0.78; 95% CI, 0.15-3.96). Between the first and third years after diagnosis, all-cause mortality in the psychotic disorder group decreased from 54.6 to 27.1 per 10 000 persons and injury and poisoning mortality decreased from 30.6 to 15.1 per 10 000 persons. Both rates, however, remained 3 times as high as in the general outpatient group (9.0 per 10 000 for all causes; 4.8 per 10 000 for injury or poisoning). Conclusions and Relevance Increases in early mortality underscore the importance of systematic intervention for young persons experiencing the first onset of psychosis. Clinicians should attend to the elevated suicide risk after the first diagnosis a psychotic disorder.
Rhythmic micro-gestures: discreet interaction on-the-go

We present rhythmic micro-gestures, micro-movements of the hand that are repeated in time with a rhythm. We present a user study that investigated how well users can perform rhythmic micro-gestures and if they can use them eyes-free with non-visual feedback. We found that users could successfully use our interaction technique (97% success rate across all gestures) with short interaction times, rating them as low difficulty as well. Simple audio cues that only convey the rhythm outperformed animations showing the hand movements, supporting rhythmic micro-gestures as an eyes-free input technique.
Health Care Professionals’ Evidence-Based Medicine Internet Searches Closely Mimic the Known Seasonal Variation of Lyme Borreliosis: A Register-Based Study

Background Both health care professionals and nonprofessionals seek medical information on the Internet. Using Web-based search engine searches to detect epidemic diseases has, however, been problematic. Physician’s databases (PD) is a chargeable evidence-based medicine (EBM) portal on the Internet for health care professionals and is available throughout the entire health care system in Finland. Lyme borreliosis (LB), a well-defined disease model, shows temporal and regional variation in Finland. Little data exist on health care professionals’ searches from Internet-based EBM databases in public health surveillance. Objective The aim of this study was to assess whether health care professionals’ use of Internet EBM databases could describe seasonal increases of the disease and supplement routine public health surveillance. Methods Two registers, PD and the register of primary health care diagnoses (Avohilmo), were used to compare health care professionals’ Internet searches on LB from EBM databases and national register-based LB diagnoses in order to evaluate annual and regional variations of LB in the whole country and in three selected high-incidence LB regions in Finland during 2011-2015. Results Both registers, PD and Avohilmo, show visually similar patterns in annual and regional variation of LB in Finland and in the three high-incidence LB regions during 2011-2015. Conclusions Health care professionals’ Internet searches from EBM databases coincide with national register diagnoses of LB. PD searches showed a clear seasonal variation. In addition, notable regional differences were present in both registers. However, physicians’ Internet medical searches should be considered as a supplementary source of information for disease surveillance.
Locating dependence clusters and dependence pollution

A dependence cluster is a set of program statements all of which are mutually inter-dependent. Such clusters can cause problems for maintenance, because a change to any statement in the cluster will have a potential impact on all statements in the cluster. This paper introduces the concept of dependence clusters and dependence pollution and shows how a simple visualisation can be used to quickly and effectively locate them. The paper presents the results of two empirical studies and several case studies which evaluate the approach. The results indicate the importance of dependence cluster analysis: for a set of 20 programs, ranging in size from 1,170 LoC to 179,623 LoC, 99.6% of clusters identified were within 1% tolerance of being identical, while dependence clusters were found to be surprisingly common: 80% of the programs studied contained clusters of 10% or more of the program.
In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress

Mammalian circadian rhythms are governed by an endogenous circadian clock system, including the molecular clock works in each cell and tissue. Adaptation of the circadian clock to different environmental stimuli such as light, food, and stress is essential for homeostasis maintenance. However, the influence of oxidative stress on the circadian clock phase is not fully understood in vitro and in vivo. Here, we examined the effects of hydrogen peroxide (H2O2)-induced oxidative stress on the PERIOD2::LUCIFERASE bioluminescence rhythm in mouse embryonic fibroblasts in vitro and in mouse peripheral tissues in vivo. The circadian clock phase changed with the dose of H2O2 and time of day in vitro; similar phase changes were observed in vivo in the circadian clocks of the peripheral tissues. In addition, mice treated with hemin-induced oxidative stress also showed phase changes of peripheral clocks, similarly as H2O2 treatment. Thus, oxidative stress can entrain circadian clock systems.