Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver

Regenerating liver was evaluated for the spatiotemporal expression of angiogenic growth factor receptors on endothelial cell (EC) membranes during revascularization resulting from 70% partial hepatectomy (PHx). Fractions enriched in EC membranes were examined by Western blot for angiogenic growth factor receptor expression from 1 to 14 days after PHx. Increases in vascular endothelial growth factor (VEGF) receptors Flt‐1 and Flk‐1/KDR, angiopoietin receptors Tie‐1, Tie‐2, and platelet‐derived growth factor receptor beta (PDGF‐Rβ), modest increases in epidermal growth factor receptor (EGF‐R), and no increase in hepatocyte growth factor receptor (c‐Met) or fibroblast growth factor receptors (FGF‐R) were observed in isolated membranes during EC proliferation. All receptors were tyrosine phosphorylated, and therefore activated, during peak expression. Immunofluorescence staining of regenerating liver identified populations with increased receptor expression, indicating cells receptive to ligand signaling. EGF‐R was upregulated evenly throughout the sinusoidal membrane, whereas c‐Met was observed on hepatocyte canaliculae, bile duct epithelium, and large vessel EC. Tie‐2 and PDGF‐Rβ were increased on sinusoidal and large vessel EC, whereas Tie‐1 was expressed in EC surrounding avascular hepatic islands. Flk‐1/KDR was increased on large vessels with slight increases on sinusoidal EC, whereas Flt‐1 was increased in arterioles, sinusoidal EC as well as in hepatocytes. Although Flt‐1 was phosphorylated on isolated hepatocytes, vascular endothelial growth factor165 (VEGF165) did not induce a proliferative or motogenic response. Proliferation assays on isolated EC indicated responsiveness to VEGF165, but synergism among several growth factors including PDGF‐BB was also observed. The data identify novel autocrine and paracrine interactions and indicate that each growth factor acts on a specific set of EC at specific times during revascularization of regenerating liver.
An Essential Viral Transcription Activator Modulates Chromatin Dynamics

Although ICP4 is the only essential transcription activator of herpes simplex virus 1 (HSV-1), its mechanisms of action are still only partially understood. We and others propose a model in which HSV-1 genomes are chromatinized as a cellular defense to inhibit HSV-1 transcription. To counteract silencing, HSV-1 would have evolved proteins that prevent or destabilize chromatinization to activate transcription. These proteins should act as HSV-1 transcription activators. We have shown that HSV-1 genomes are organized in highly dynamic nucleosomes and that histone dynamics increase in cells infected with wild type HSV-1. We now show that whereas HSV-1 mutants encoding no functional ICP0 or VP16 partially enhanced histone dynamics, mutants encoding no functional ICP4 did so only minimally. Transient expression of ICP4 was sufficient to enhance histone dynamics in the absence of other HSV-1 proteins or HSV-1 DNA. The dynamics of H3.1 were increased in cells expressing ICP4 to a greater extent than those of H3.3. The dynamics of H2B were increased in cells expressing ICP4, whereas those of canonical H2A were not. ICP4 preferentially targets silencing H3.1 and may also target the silencing H2A variants. In infected cells, histone dynamics were increased in the viral replication compartments, where ICP4 localizes. These results suggest a mechanism whereby ICP4 activates transcription by disrupting, or preventing the formation of, stable silencing nucleosomes on HSV-1 genomes.
Study on the Antibacterial Performance of the Antibacterial Shutter Blades

This study used Ag-embedded nanoTiO2, xylan and water-soluble Chitosan as antibacterial agents, respectively prepared shutter blades through the treating solution of the different concentration and the different drug loading amount of the poplar veneer. Through a single factor experiment, this paper analyzes that the different antibacterial agent, concentration of antibacterial agent and the drug loading amount have an effect on the antibacterial properties of the shutter blades. The results show that the order of antibacterial performance of the shutter blades impregnated antibacterial agents is the Ag-embedded nanoTiO2, Chitosan, Xylan. Comprehensiv-ely thought the antibacterial properties and economic index, the optimal concentration of the Ag-embedded nanoTiO2 impregnation solution is 1%.
Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

Large-scale motions of biomolecules involve linear elastic deformations along low-frequency normal modes, but for function nonlinearity is essential. In addition, unlike macroscopic machines, biological machines can locally break and then reassemble during function. We present a model for global structural transformations, such as allostery, that involve large-scale motion and possible partial unfolding, illustrating the method with the conformational transition of adenylate kinase. Structural deformation between open and closed states occurs via low-frequency modes on separate reactant and product surfaces, switching from one state to the other when energetically favorable. The switching model is the most straightforward anharmonic interpolation, which allows the barrier for a process to be estimated from a linear normal mode calculation, which by itself cannot be used for activated events. Local unfolding, or cracking, occurs in regions where the elastic stress becomes too high during the transition. Cracking leads to a counterintuitive catalytic effect of added denaturant on allosteric enzyme function. It also leads to unusual relationships between equilibrium constant and rate like those seen recently in single-molecule experiments of motor proteins.
MathGirls: Toward Developing Girls' Positive Attitude and Self-Efficacy through Pedagogical Agents

MathGirls is a pedagogical-agent-based environment designed for high school girls learning introductory algebra. Since females are in general more interested in interactive computing and more positive about the social presence of pedagogical agents, the environment provides a girl-friendly social learning environment, where pedagogical agents encourage the girls to build constructive views of learning math. This study investigated the impact of agent presence on changes in the girls' math attitude, their math self-efficacy, and their learning; on the girls' choice of their agents; and, on their perceptions of agent affability. The results revealed that the girls with an agent developed a more positive attitude and increased self-efficacy significantly, compared to the girls without an agent. Both groups showed significant increase in their learning. The study also showed that the girls chose female agents significantly more than male agents as their learning partners and perceived peer-like agents as more affable than teacher-like agents. The finding confirms the instructional value of pedagogical agents functioning as a social cognitive tool [1].
Development of eco-friendly surface modification process for 316L austenitic stainless steel weld cladding

Austenitic stainless steels are used for industrial applications due to their improved corrosion resistance properties. Their poor tribological behaviour is a barrier for their wider application under corrosion–wear conditions taking place between rolling and sliding contacts. The present work has been conducted to develop a low temperature liquid nitriding process for austenitic stainless steel claddings to impart better resistance to corrosion–wear. This work presents the results of the corrosion and wear tests performed on liquid nitrided AISI 316L stainless steel claddings. The wear tests were conducted with a Ducom pin on disc machine under rolling–sliding conditions. Surface and subsurface were studied by an optical microscope. The hardness and depth of the modified layer were measured in the sectioned samples using a microhardness tester. The optical metallographic microstructures of the liquid nitrided specimens were revealed using Marbles reagent. The electrochemical behaviour of the liquid nitrided specimens was investigated with a dc anodic potentiodynamic polarisation technique.
Neural and Immunological Synaptic Relations

A synapse is a stable adhesive junction between two cells across which information is relayed by directed secretion. The nervous system and immune system utilize these specialized cell surface contacts to directly convey and transduce highly controlled secretory signals between their constituent cell populations. Each of these synaptic types is built around a microdomain structure comprising central active zones of exocytosis and endocytosis encircled by adhesion domains. Surface molecules that may be incorporated into and around the active zones contribute to modulation of the functional state of the synapse.
PUF as a sensor

The idea to use physical unclonable function (PUF) as a sensor is proposed. Environment-dependent behavior of PUF, which is conventionally unwanted, is used for sensing. Such PUF-based sensor has advantages over ordinary sensors. As a proof of concept, a voltage sensor is prototyped using an ASIC implementation of glitch PUF. The performance of the PUF-based sensor is evaluated by injecting pulses to power supply. The experiment emulates a hostile environment in which an attacker is attempting to inject fault. As a result, the PUF-based sensor successfully detects the injected pulses at high accuracy.
Dynamics of keyhole and molten pool in laser welding

In laser and electron-beam welding, a deep cavity called a keyhole or beam hole is formed in the weld pool due to the intense recoil pressure of evaporation. The formation of the keyhole leads to a deep penetration weld with a high aspect ratio and this is the most advantageous feature of welding by high-energy-density beams. However, a hole drilled in a liquid is primarily unstable by its nature and the instability of the keyhole also causes the formation of porosity or cavities in the weld metal. In particular, the porosity formation is one of the serious problems in very high-power laser welding, but its mechanism has not been well understood. The authors have conducted systematic studies on observation of keyhole as well as weld pool dynamics and their related phenomena to reveal the mechanism of porosity formation and its suppression methods. The article will describe the real-time observation of keyhole and plume behaviors in the pulsed and continuous-wave laser welding by high-speed optical and x-ray transmission methods, the cavity formation process and its suppression measures.
I3A Language Recognition System for Albayzin 2010 LRE

This paper describes the two systems submitted to the Albayzin 2010 Language Recognition Evaluation by I3A. This evaluation is similar to the one organized by NIST every 2 years, but the languages to be recognized are those spoken in the Iberian peninsula (Spanish, Catalan, Basque, Galician and Portuguese) plus English. Both submissions are a fusion of ﬁve phonotactic and three acoustic subsystems. The only difference between them is the normalization and fusion of the scores. State-of-the art methods for Language Recognition are adapted to and investigated in the KALAKA-2 database. Our primary system was ranked in the ﬁrst position of the evaluation.
The Research of the Computation Method for the Ratio of Land Price to House Price

The ratio of land price to house price (LPHP-ratio) is an indicator commonly used to reflect the relationship between house price and land price. However, the precise computation method for the ratio has long remained unspecific, and the different results using different computation methods will exert different influence upon people's perception and judgment of the real relationship between house price and land price. Three different types of LPHP-ratios, namely Static-LPHP-ratio, Dynamic-LPHP-ratio and Internal-LPHP-ratio are proposed in this paper using different methods of computation. An empirical study on the real estate market in Hangzhou during the period 2003-2008 is reported and discussed in the following.
Stent Thrombosis is the Primary Cause of ST-Segment Elevation Myocardial Infarction following Coronary Stent Implantation: A Five Year Follow-Up of the SORT OUT II Study

Background The widespread use of coronary stents has exposed a growing population to the risk of stent thrombosis, but the importance in terms of risk of ST-segment elevation myocardial infarctions (STEMIs) remains unclear. Methods We studied five years follow-up data for 2,098 all-comer patients treated with coronary stents in the randomized SORT OUT II trial (mean age 63.6 yrs. 74.8% men). Patients who following stent implantation were readmitted with STEMI were included and each patient was categorized ranging from definite- to ruled-out stent thrombosis according to the Academic Research Consortium definitions. Multivariate logistic regression was performed on selected covariates to assess odds ratios (ORs) for definite stent thrombosis. Results 85 patients (4.1%), mean age 62.7 years, 77.1% men, were admitted with a total of 96 STEMIs, of whom 60 (62.5%) had definite stent thrombosis. Notably, definite stent thrombosis was more frequent in female than male STEMI patients (81.8% vs. 56.8%, p = 0.09), and in very late STEMIs (p = 0.06). Female sex (OR 3.53 [1.01–12.59]) and clopidogrel (OR 4.43 [1.03–19.01]) was associated with increased for definite stent thrombosis, whereas age, time since stent implantation, use of statins, initial PCI urgency (STEMI [primary PCI], NSTEMI/unstable angina [subacute PCI] or stable angina [elective PCI]), and glucose-lowering agents did not seem to influence risk of stent thrombosis. Conclusion In a contemporary cohort of coronary stented patients, stent thrombosis was evident in more than 60% of subsequent STEMIs.
On the dynamics of dengue virus type 2 with residence times and vertical transmission

A two-patch mathematical model of Dengue virus type 2 (DENV-2) that accounts for vectors’ vertical transmission and between patches human dispersal is introduced. Dispersal is modelled via a Lagrangian approach. A host-patch residence-times basic reproduction number is derived and conditions under which the disease dies out or persists are established. Analytical and numerical results highlight the role of hosts’ dispersal in mitigating or exacerbating disease dynamics. The framework is used to explore dengue dynamics using, as a starting point, the 2002 outbreak in the state of Colima, Mexico.
Shelf Life of PMR Polyimide Monomer Solutions and Prepregs Extended

PMR (Polymerization of Monomeric Reactants) technology was developed in the mid-1970's at the NASA Glenn Research Center at Lewis Field for fabricating high-temperature stable polyimide composites. This technology allowed a solution of polyimide monomers or prepreg (a fiber, such as glass or graphite, impregnated with PMR polyimide monomers) to be thermally cured without the release of volatiles that cause the formation of voids unlike the non-PMR technology used for polyimide condensation type resins. The initial PMR resin introduced as PMR 15 is still commercially available and is used worldwide by aerospace industries as the state-of-the-art resin for high-temperature polyimide composite applications. PMR 15 offers easy composite processing, excellent composite mechanical property retention, a long lifetime at use temperatures of 500 to 550 F, and relatively low cost. Later, second-generation PMR resin versions, such as PMR II 50 and VCAP 75, offer improvements in the upper-use temperature (to 700 F) and in the useful life at temperature without major compromises in processing and property retention but with significant increases in resin cost. Newer versions of nontoxic (non-methylene dianiline) PMR resins, such as BAX PMR 15, offer similar advantages as originally found for PMR 15 but also with significant increases in resin cost. Thus, the current scope of the entire PMR technology available meets a wide range of aeronautical requirements for polymer composite applications.
Wiener Model Identification of Blast Furnace Ironmaking Process

algorithms like singular value decomposition (SVD) and QR factorization. It an attractive alternative to input–out-put methods due to simple and general parameterization of multiple- input multiple-output (MIMO) system. The present work deals with application of subspace based Wiener model to the prediction of silicon content in It accounts for characteristic of and is compared like The proposed model is then tested in from of Baotou It is found that the identiﬁed To this the is To account for the nonlinearity of blast furnace ironmaking process, a nonlinear Wiener identiﬁcation algorithm is presented. The system consists of a linear time invariant (LTI) subsystem followed by a static nonlinearity. The inverse of the nonlinearity is assumed to be a linear combination of known nonlinear basis functions and the linear subspace algorithm is used to identify the model. The inputs to the model are parameters regarded to be most responsible for the ﬂuctuation of thermal state in blast furnace while the output to the model is silicon content in hot metal. The identiﬁed Wiener model is then tested on datasets obtained from No. 6 Blast Furnace from Baotou Steel. It is found that the blast furnace of concern is a short memory system, so that for each prediction the Wiener method is retrained. It is shown that the retrained model well improves the predictive accuracy.
The Equivariant Tamagawa Number Conjecture: A survey

We give a survey of the equivariant Tamagawa number (a.k.a. Bloch-Kato) conjecture with particular emphasis on proven cases. The only new result is a proof of the 2-primary part of this conjecture for Tate-motives over abelian fields. This article is an expanded version of a survey talk given at the conference on Stark’s conjecture, Johns Hopkins University, Baltimore, August 5-9, 2002. We have tried to retain the succinctness of the talk when covering generalities but have considerably expanded the section on examples. Most of the following recapitulates well known material due to many people. Section 3 is joint work with D. Burns (for which [14], [15], [16], [17] are the main references). In section 5.1 we have given a detailed proof of the main result which also covers the prime l = 2 (unavailable in the literature so far).
Towards evidence based medicine for paediatricians

A16 month old boy with stage IV neuroblastoma and hypoalbuminaemia presented with a left sided haemorrhagic pleural effusion. He subsequently developed generalised oedema. You wonder if there was a role of albumin infusion in correcting hypoalbuminaemia and colloid osmotic pressure (COP), in order to treat the extravasation of fluid into tissue spaces. In order to give the best care to patients and families, paediatricians need to integrate the highest quality scientific evidence with clinical expertise and the opinions of the family. Archimedes seeks to assist practising clinicians by providing “evidence based” answers to common questions which are not at the forefront of research but are at the core of practice. They are based on an original format from the Journal of Accident and Emergency Medicine. A word of warning. These best evidence topic summaries (BETs) are not systematic reviews, though they are as exhaustive as a practising clinician can produce. They make no attempt to statistically aggregate the data, nor search the grey, unpublished literature. What Archimedes offers are practical, best evidence based answers to practical, clinical questions. Each topic follows the same format. A description of the clinical setting is followed by a structured clinical question. (These aid in focusing the mind, assisting searching, and gaining answers.) A brief report of the search used follows—this has been performed in a hierarchical way, to search for the best quality evidence to answer the question. A table provides a summary of the evidence and key points of the critical appraisal. For further information on critical appraisal, and the measures of effect (such as number needed to treat, NNT), books by Sackett and Moyer may help. A commentary is provided to pull the information together, and for accessibility, a box provides the clinical bottom lines. Readers wishing to submit their own questions—with best evidence answers—are encouraged to read the Instructions for Authors at http://www.archdischild. com. Three topics are covered in this issue of the journal. c Albumin infusion in hypoalbuminaemic children with oncological disease c Magnesium sulphate in paediatric status asthmaticus c Chiropractic in infantile colic
Treatment of cervical cancer precursors: influence of age, completeness of excision and cone depth on therapeutic failure, and on adverse obstetric outcomes

Sir, We agree with Professor Westgate that umbilical cord compression is one of the possible causes of fetal hypoxia during shoulder dystocia, and that the cord pH may reflect the fetal condition before shoulder dystocia, as we have demonstrated that the presence of a nonreassuring fetal heart rate pattern is one of the factors independent of the pH values. We also agree with Professor Westgate that umbilical cord compression may explain the ‘dissociation’ between cord gas values and the occurrence of hypoxic ischaemic encephalopathy (HIE) in some of the cases. Having said that, we believe that the pathophysiological mechanism could be multiple, and premature separation of placenta is one of the possibilities, as the rate of decline of pH of 0.011 per minute is very similar to women with placental abruption or cord prolapse. Furthermore, we postulate that the compression of the fetal neck and carotid vessels by the maternal tissue at the pelvic outlet level may contribute to the development of HIE, as well as explain the ‘dissociation’ between cord gas values and the occurrence of HIE. When the neck vessels are compressed, not only is there impairment of the supply of oxygenated blood to the brain, but the elimination of products of anaerobic metabolism by brain hypoxia is also delayed. Therefore the cord blood pH, which reflects the systemic circulation, may fail to reflect the degree of cerebral hypoxia and acidosis. This hypothesis may also explain why the Zavanelli manoeuvre may help to improve neonatal outcome even after a long head-to-body delivery interval, as the circulation to the head may be improved after replacement of the fetal head back into the vagina. Nonetheless, we suggest that Apgar score at 5 minutes may be a more robust indicator of brain hypoxia in shoulder dystocia, as it reflects not only the cardiorespiratory status (colour and pulse rate), but also the central neurological responses (breathing, muscle tone and reflex). j
Ieee Transactions on Communications, Accepted for Publication Generalized Belief Propagation for the Noiseless Capacity and Information Rates of Run-length Limited Constraints

— The performance of the generalized belief propagation algorithm to compute the noiseless capacity and mutual information rates of finite-size two-dimensional and three-dimensional run-length limited constraints is investigated. In both cases, the problem is reduced to estimating the partition function of graphical models with cycles. The partition function is then estimated using the region-based free energy approximation technique. For each constraint, a method is proposed to choose the basic regions and to construct the region graph which provides the graphical framework to run the generalized belief propagation algorithm. Simulation results for the noiseless capacity of different constraints as a function of the size of the channel are reported. In the cases that tight lower and upper bounds on the Shannon capacity exist, convergence to the Shannon capacity is discussed. For noisy constrained channels, simulation results are reported for mutual information rates as a function of signal-to-noise ratio.