Miracle-dz/UniFAR-FTUs huggingface dataset:
PRESS: PRotEin S-Sulfenylation server

MOTIVATION Transient S-sulfenylation of cysteine thiols mediated by reactive oxygen species plays a critical role in pathology, physiology and cell signaling. Therefore, discovery of new S-sulfenylated sites in proteins is of great importance towards understanding how protein function is regulated upon redox conditions. RESULTS We developed PRESS (PRotEin S-Sulfenylation) web server, a server which can effectively predict the cysteine thiols of a protein that could undergo S-sulfenylation under redox conditions. We envisage that this server will boost and facilitate the discovery of new and currently unknown functions of proteins triggered upon redox conditions, signal regulation and transduction, thus uncovering the role of S-sulfenylation in human health and disease. AVAILABILITY AND IMPLEMENTATION The PRESS web server is freely available at http://press-sulfenylation.cse. uoi.gr/ CONTACTS agtzakos@gmail.com or gtzortzi@cs.uoi.gr SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Suzhi, Relevance, and the New Curriculum

There have been ongoing discussions about the most recent curriculum reform in China. The new curriculum aims at a more quality-oriented (suzhi) education and producing more well-rounded citizens to meet the challenges of global competition. However, it is questioned how suzhi education is possible with entrance examination still being the sole sorting mechanism. A semester-long ethnography in a rural middle school in northwest China reveals how rural students face many challenges with the new curriculum. Based on interviews, analyses of textbooks, and observations of classroom teaching, the study examines how rural students question the relevance of their curriculum and further the meaning of formal schooling. In addition to the dichotomy between an exam-oriented and quality-oriented curriculum, students are also troubled by the dichotomy between general/academic education and relevant/practical education. The study raises concerns about the urban-centered curriculum and how the rural community's absence in the picture has led to rural students' increasing disengagement in schooling and even dropout. It also reveals how the substance of suzhi education and the new curriculum have further reduced rural students' chance to move upward socially. The article concludes by pushing for discussions on how formal schooling can better serve rural children and youth.
Comparison of the Angles and Corresponding Moments in the Knee and Hip During Restricted and Unrestricted Squats

Abstract Lorenzetti, S, Gülay, T, Stoop, M, List, R, Gerber, H, Schellenberg, F, and Stüssi, E. Comparison of the angles and corresponding moments in the knee and hip during restricted and unrestricted squats. J Strength Cond Res 26(10): 2829–2836, 2012—The aim of this study was to compare the angles and corresponding moments in the knee and hip during squats. Twenty subjects performed restricted and unrestricted squats with barbell loads that were 0, ¼, and ½ their body weight. The experimental setup consisted of a motion capture system and 2 force plates. The moments were calculated using inverse dynamics. During the unrestricted squats, the maximum moments in the knee were significantly higher, and those in the hip were significantly lower than during restricted squats. At the lowest position, the maximum knee flexion angles were approximately 86° for the restricted and approximately 106° for the unrestricted techniques, whereas the maximum hip flexion angle was between 95° and 100°. The higher moments in the hip during restricted squats suggest a higher load of the lower back. Athletes who aim to strengthen their quadriceps should consider unrestricted squats because of the larger knee load and smaller back load.
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF

Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood circulation to the distal target organ. Here, we investigate whether leptin, an endocrine hormone, induces the formation of vascular fenestrations and permeability, and we characterize its angiogenic property in the presence of other angiogenic factors. We provide evidence that leptin-induced new blood vessels are fenestrated. Under physiological conditions, capillary fenestrations are found in the leptin-producing adipose tissue in lean mice. In contrast, no vascular fenestrations were detected in the adipose tissue of leptin-deficient ob/ob mice. Thus, leptin plays a critical role in the maintenance and regulation of vascular fenestrations in the adipose tissue. Leptin induces a rapid vascular permeability response when administrated intradermally. Further, leptin synergistically stimulates angiogenesis with fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF), the two most potent and commonly expressed angiogenic factors. These findings demonstrate that leptin has another new function—the increase of vascular permeability.
Pyrosequencing the Midgut Transcriptome of the Banana Weevil Cosmopolites sordidus (Germar) (Coleoptera: Curculionidae) Reveals Multiple Protease-Like Transcripts

The banana weevil Cosmopolites sordidus is an important and serious insect pest in most banana and plantain-growing areas of the world. In spite of the economic importance of this insect pest very little genomic and transcriptomic information exists for this species. In the present study, we characterized the midgut transcriptome of C. sordidus using massive 454-pyrosequencing. We generated over 590,000 sequencing reads that assembled into 30,840 contigs with more than 400 bp, representing a significant expansion of existing sequences available for this insect pest. Among them, 16,427 contigs contained one or more GO terms. In addition, 15,263 contigs were assigned an EC number. In-depth transcriptome analysis identified genes potentially involved in insecticide resistance, peritrophic membrane biosynthesis, immunity-related function and defense against pathogens, and Bacillus thuringiensis toxins binding proteins as well as multiple enzymes involved with protein digestion. This transcriptome will provide a valuable resource for understanding larval physiology and for identifying novel target sites and management approaches for this important insect pest.
Patterns of Individual and Organizational Adaptation: The Impact of Blacks in Predominantly White Organizations,

Abstract : The objective of the study was to explore and describe the impact of the induction of an increasing number of black minority members within the boundaries of two types of traditionally and predominantly white formal organizations: institutions of higher education and the United States Navy. An exploratory, field research design was used, employing both qualitative and quantitative methods of data gathering from a variety of sources. The study was conducted during a post-social revolutionary period. Organizational Responses: The organizations were responsive to the forces operating in the society; however, their responsiveness was dictated by the strength of force inherent in their historical values and commitments in the face of new or emerging values. Tensions were generated by adherence to old values while simultaneously evincing compliance with new ones. While the number of black recruits to the organizations was increasing, the number was insignificant to effect any structural changes. Group Responses: The adaptive patterns of blacks as an ethinic group were influenced by three controlling variables: group size, perceived oppressiveness of the organization and prevailing conditions in the society. During the 1960's the number of blacks in the organizations was very small; however, they formed a cohesive group. Individual Responses: It is at the individual level that the range and variation of adaptive patterns among blacks can be seen most clearly.
WDM-based local lightwave networks. II. Multihop systems

For pt.I see ibid., vol.6, no.3, p.12-27, 1992. A survey of wavelength-division-multiplexing (WDM)-based local lightwave networks is presented. The general characteristics of multihop systems are discussed, and various multihop approaches are reviewed. The construction of optimal structures based on minimizing the maximum link flow and optimizations based on minimization of the mean network packet delay are also reviewed. Regular topologies that have been studied as candidates for multihop lightwave networks, including the perfect shuffle, the de Bruijn graph, the toroid, and the hypercube, are discussed. Near-optimal node placement algorithms and shared-channel multihop systems are also discussed. <<ETX>>
AntibodyComplement Function but Not a Lack of Results from Impaired Salmonella against Invasive African Nontyphoidal Absent Bactericidal Activity of Mouse Serum

Nontyphoidal strains of Salmonella are a major cause of fatal bacteremia in Africa. Developing a vaccine requires an improved understanding of the relevant mechanisms of protective immunity, and the mouse model of Salmonella infection is useful for studying immunity to Salmonella in vivo. It is important to appreciate the similarities and differences between immunity to Salmonella in mice and men. Ab is important for protection against nontyphoidal Salmonella in both species, and we have previously found an important role for Ab in cell-free complement-mediated bactericidal activity against Salmonella in Africans. It is unclear whether this modality of immunity is relevant in the mouse model. C57BL/6, BALB/c, and C3H mice immunized with heat-killed Salmonella Typhimurium strains D23580 (African invasive strain) and SL1344 and live-attenuated strain SL3261 produced a Salmonella -speciﬁc Ab response. Sera from these mice deposited reduced levels of C3 on Salmonella compared with human sera and were unable to kill both wild-type and galE 2 rough mutant of D23580, indicating absent cell-free killing via classical and alternative complement pathways. Supplementing immune mouse sera with human complement enabled killing of Salmonella , whereas addition of human anti- Salmonella Ab to immune mouse sera had no effect. These ﬁndings indicate that mouse serum cannot affect cell-free complement-dependent killing of Salmonella , because of the reduced mouse complement ability to kill these bacteria compared with human complement. This difference in Ab-dependent immunity to Salmonella in mice and men must be considered when applying ﬁndings from the mouse model of Salmonella disease and vaccination response to man. The Journal of Immunology , 2011, 186: 000–000.
A “cultura como recurso” e a auto-explicitação do gesto cultural em programas de televisão

El objetivo de este articulo es evidenciar como la television deja ver procesos culturales contemporaneos. Especificamente, investigamos la tesis de la "cultura como recurso" (Yudice, 2004); y demostramos como la television puede cumplir un importante rol en la comprension de esa nueva forma de practica cultural, en la sociedad contemporanea. Para tanto, desarrollamos el analisis de un episodio de la serie "Minha Periferia" - exhibido dentro del programa "Fantastico" de la "Rede Globo de Televisao", donde la presentadora aborda tanto a la produccion cultural como a los moradores de la periferia. Metodologicamente, proponemos una articulacion entre el genero televisivo y el modo de direccionamiento, para comprender como este programa presenta la referida tesis. Tal persperctiva nos permite investigar lo caracteristico del lenguaje televisivo y lidiar con las especificacidades del contexto socio-cultural en el cual el procuto esta inserido.
Self-similarity cryptanalysis of the block cipher ITUbee

Recent developments in the resource constrained devices have led to a renewed interest in designing light-weight primitives with inventive and unconventional structures. Using round-dependent constants instead of a strong key schedule is one of the most widely used trick against the self-similarity cryptanalysis in recent cipher proposals. So far there has been little discussion about the effect of the round constants on the security of the ciphers. In this study, the authors identify several weaknesses in round-reduced versions of the block cipher ITUbee, which was presented recently at LightSec 2013. These weaknesses allow to build relations between the round constants. The author's technique leads to several cryptanalysis in the weak-key, related-key and single-key models and shows that the resistance of ITUbee against self-similarity cryptanalysis is not independent of the values of round constants. They show that the round-reduced cipher under a fraction of the keys is distinguishable from an ideal random permutation. Then they utilise a similar technique to show there exists a deterministic related-key differential distinguisher for up to eight rounds of the cipher. This observation leads to the decrease of the security of 8-round ITUbee in the single-key model by one bit.
Transient management of reconfigurable digital filters in case of sinusoidal excitation

Reconfigurable digital filters are promising solutions to filtering problems in hybrid systems, where digital filters with time-invariant configuration are found to be inappropriate. However, reconfiguration of digital filters causes intermediate disturbances, reconfiguration transients that have to be minimized by proper transient management. In this paper, the one-step reconfiguration method is analyzed for reconfigurable digital filters in case of sinusoidal excitation. First, the energy function of the reconfiguration transient is formulated, and later analyzed. The implementation structure is identified as key factor influencing the energy of the reconfiguration transients. Orthogonal implementation structures are proposed as the most suitable alternatives.
PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications

Multimodality imaging and, more specifically, the combination of PET and CT has matured into an important diagnostic tool. During the same period, concepts for PET scanners integrated into an MR tomograph have emerged. The excellent soft-tissue contrast of MRI and the multifunctional imaging options it offers, such as spectroscopy, functional MRI, and arterial spin labeling, complement the molecular information of PET. The development of a fully integrated PET/MRI system is technologically challenging. It requires not only significant modifications of the PET detector to make it compact and insensitive to magnetic fields but also a major redesign of the MRI hardware.
Core Muscle Activity during TRX Suspension Exercises with and without Kinesiology Taping in Adults with Chronic Low Back Pain: Implications for Rehabilitation

This study aimed to examine the effects of kinesiology taping (KT) and different TRX suspension workouts on the amplitude of electromyographic (EMG) activity in the core muscles among people with chronic low back pain (LBP). Each participant (total n = 21) was exposed to two KT conditions: no taping and taping, while performing four TRX suspension exercises: (1) hamstring curl, (2) hip abduction in plank, (3) chest press, and (4) 45-degree row. Right transversus abdominis/internal oblique (TrAIO), rectus abdominis (RA), external oblique (EO), and superficial lumbar multifidus (LMF) activity was recorded with surface EMG and expressed as a percentage of the EMG amplitude recorded during a maximal voluntary isometric contraction of the respective muscles. Hip abduction in plank increased TrAIO, RA, and LMF EMG amplitude compared with other TRX positions (P < 0.008). Only the hamstring curl was effective in inducing a high EMG amplitude of LMF (P < 0.001). No significant difference in EMG magnitude was found between the taping and no taping conditions overall (P > 0.05). Hip abduction in plank most effectively activated abdominal muscles, whereas the hamstring curl most effectively activated the paraspinal muscles. Applying KT conferred no immediate benefits in improving the core muscle activation during TRX training in adults with chronic LBP.
How we know our minds: The illusion of first-person knowledge of intentionality

Abstract As adults we believe that our knowledge of our own psychological states is substantially different from our knowledge of the psychological states of others: First-person knowledge comes directly from experience, but third-person knowledge involves inference. Developmental evidence suggests otherwise. Many 3-year-old children are consistently wrong in reporting some of their own immediately past psychological states and show similar difficulties reporting the psychological states of others. At about age 4 there is an important developmental shift to a representational model of the mind. This affects children's understanding of their own minds as well as the minds of others. Our sense that our perception of our own minds is direct may be analogous to many cases where expertise provides an illusion of direct perception. These empirical findings have important implications for debates about the foundations of cognitive science.
Hyperbaric oxygen for experimental intracerebral haemorrhage: Systematic review and stratified meta-analysis

ABSTRACT Objective: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and meta-analysis on studies describing the efficacy of HBO in animal models of ICH. Methods: Studies were identified by searching mainstream databases through November 2015. The efficacy of HBO in animal models of ICH was assessed by changes in the brain water content (BWC), neurobehavioural outcome (NO) or both. Subgroup analyses were performed according to different design characteristics. Results: In total 15 studies met our inclusion criteria. HBO can reduce the BWC (−0.982, 95% CI, −1.148 to −0.817; P < 0.01; 57 comparisons), and improve NO (−0.767, 95% CI, −1.376 to −0.159; P < 0.01; eight comparisons). HBO was most effective in reducing BWC when given 72 h after ICH for a 4- to 5-day consecutive treatment at the chamber pressure of 3.0 atmosphere absolute. Efficacy was higher with phenobarbital anaesthesia, the blood infusion model and in rabbits. Conclusion: Although HBO was found to be effective in experimental ICH, additional confirmation is needed due to possible publication bias, poor study quality and the limited number of studies conducting clinical trials.
Practicing Servant-Leadership: Succeeding Through Trust, Bravery, and Forgiveness

Foreword: Why Servant-Leadership Matters (Warren Bennis). Preface. Acknowledgments. The Editors and The Greenleaf Center for Servant-Leadership. The Contributors. 1. Who Is the Servant-Leader? (Robert K. Greenleaf). 2. The Understanding and Practice of Servant-Leadership (Larry C. Spears). 3. The Unique Double Servant-Leadership Role of the Board Chairperson (John Carver). 4. Love and Work A Conversation with James A. Autry. 5. Servant-Leadership and Philanthropic Institutions (John C. Burkhardt, Larry C. Spears). 6. On the Right Side of History (John C. Bogle). 7. Anatomy of a Collaboration: An Act of Servant-Leadership (Wendell J.Walls). 8. Servant-Leadership Characteristics in Organizational Life (Don DeGraaf, Colin Tilley, Larry Neal). 9. Toward a Theology of Institutions (David L. Specht with Richard R. Broholm). 10. Foresight as the Central Ethic of Leadership (Daniel H. Kim). 11. Servant-Leadership, Forgiveness, and Social Justice (Shann R. Ferch). 12. The Servant-Leader: From Hero to Host An Interview with Margaret J. Wheatley. Endnotes. Recommended Reading. Index.
Characterization of Silicon Photomultiplier (SiPM) for Silicon Geiger Hybrid Tube (SiGHT) to Improve Dark Matter Experiments

For the purpose of direct dark matter detection experiments, highly sensitive photodetectors are needed. The UCLA dark matter team is testing and developing a novel hybrid photodector called Silicon Geiger Hybrid Tube (SiGHT) that can potentially replace the currently used photomultiplier tube. The main component of SiGHT is the silicon photomultiplier. The characterization of the SiPM is being discussed here. Data were taken for five Sensl SiPM type MicroSM-30035-X13-NE. With the amplifier, the average gains at mininum operating voltage is 8.8374 × 106.
Investigating the Link between Adult Neurogenesis and the Innate Immune System

Adult neurogenesis is defined as the mechanism by which new neurons are generated in adult organisms and is widely conserved across many different species. In mammalian systems, adult neurogenesis is mediated by the presence of neuronal stem cells. These stem cells lie in a neurogenic niche, divide asymmetrically (one daughter cell remains a stem cell [self-renewal], the other differentiates) and are multipotent. In the crayfish, Procambarus clarkii (Crustacea, Decapoda), 1-generation neuronal precursors, functionally analogous to neuronal stem cells, also lie within bilateral neurogenic niches on the ventral surface of the brain. However, these precursors divide symmetrically, as both daughter cells leave the neurogenic niche, divide again, and their descendants differentiate. Nonetheless, the neuronal precursor population in the niche is never depleted, indicating there must be an extrinsic source that replenishes these cells. Recently, our lab proposed that the innate immune system is the source of 1-generation neuronal precursors in the crayfish neurogenic niche. The innate immune system is composed of two main regions: the anterior proliferation center (APC) and the posterior hematopoietic tissue (HPT) located on the surface of the stomach. Here, we expand upon our current knowledge of the innate immune system and the interaction between the innate immune system and the neurogenic niche, with the ultimate objective of localizing the source tissue of the neuronal precursors. The overarching goal of this thesis is to gain further understanding of the contribution of the innate immune tissues to adult neurogenesis by performing timed studies using BrdU and examining the cell cycle times in the APC and HPT, as well as in vitro studies necessary for characterizing the morphology of cells that are attracted to the niche and that transform into neuronal
Probabilistic 21st and 22nd century sea‐level projections at a global network of tide‐gauge sites

Sea‐level rise due to both climate change and non‐climatic factors threatens coastal settlements, infrastructure, and ecosystems. Projections of mean global sea‐level (GSL) rise provide insufficient information to plan adaptive responses; local decisions require local projections that accommodate different risk tolerances and time frames and that can be linked to storm surge projections. Here we present a global set of local sea‐level (LSL) projections to inform decisions on timescales ranging from the coming decades through the 22nd century. We provide complete probability distributions, informed by a combination of expert community assessment, expert elicitation, and process modeling. Between the years 2000 and 2100, we project a very likely (90% probability) GSL rise of 0.5–1.2 m under representative concentration pathway (RCP) 8.5, 0.4–0.9 m under RCP 4.5, and 0.3–0.8 m under RCP 2.6. Site‐to‐site differences in LSL projections are due to varying non‐climatic background uplift or subsidence, oceanographic effects, and spatially variable responses of the geoid and the lithosphere to shrinking land ice. The Antarctic ice sheet (AIS) constitutes a growing share of variance in GSL and LSL projections. In the global average and at many locations, it is the dominant source of variance in late 21st century projections, though at some sites oceanographic processes contribute the largest share throughout the century. LSL rise dramatically reshapes flood risk, greatly increasing the expected number of “1‐in‐10” and “1‐in‐100” year events.