Miracle-dz/UniFAR-FTUs huggingface dataset:
Supplemental L-arginine attenuates pulmonary hypertension syndrome (ascites) in broilers.

The incidence of pulmonary hypertension syndrome (PHS; ascites) was evaluated in two experiments using broiler breeder male by-product chicks exposed after 3 wk of age to cool environmental temperatures (10 to 15 C). In Experiment 1, 3- to 6-wk-old birds were fed a grower diet to which 0 (Control), . 25, . 5, or 1% supplemental L-arginine HCl had been added. During Weeks 7 to 8, all groups in Experiment 1 were fed a finisher diet containing no supplemental arginine. In Experiment 2, the Control group received no supplemental arginine, a second group was fed a grower diet supplemented with 1% L-arginine HCl (Weeks 3 to 6), and a third group was fed grower and finisher diets supplemented with 1% L-arginine HCl (Weeks 3 to 8). Cumulative PHS mortality was significantly reduced by 1% L-arginine HCl on Days 34 to 46 in Experiment 1. When data from all birds fed grower or finisher diets supplemented with 1% L-arginine HCl were pooled in Experiment 2, cumulative PHS mortality was marginally lower (P = .065) than for the Control group. Supplemental L-arginine HCl had no effect on final body weights, weight gain, or feed conversion in either experiment. Neither body weight on Day 1 or 21 nor net weight gain from Days 1 to 21 determined susceptibility to PHS during the subsequent grower and finisher intervals in either experiment. (ABSTRACT TRUNCATED AT 250 WORDS)
REDUCING STEREOTYPE THREAT EFFECTS Creating a Critical Mass Eliminates the Effects of Stereotype Threat on Women ’ s Mathematical Performance Declaration of Competing

Background: Women in mathematical domains may become attuned to situational cues that signal a discredited social identity, contributing to their lower achievement and underrepresentation. Aim: The current study examined whether heightened ingroup representation alleviates the effects of stereotype threat on women’s mathematical performance. It further investigated whether single-sex testing environments and stereotype threat influenced participants to believe that their ability was fixed (fixed mindset) rather than a trait that could be developed (growth mindset). Sample and Method: One hundred and forty-four female participants were assigned randomly to a self-as-target or group-as-target stereotype threat condition or to a control condition. They completed a modular arithmetic maths test and a mindset questionnaire either alone or in same-sex groups of 3-5 individuals. Results: Participants solved fewer mathematical problems under self-as-target and group-astarget stereotype threat when they were tested alone but these performance deficits were eliminated when they were tested in single-sex groups. Participants reported a weaker growth mindset when they were tested under stereotype threat and in singlesex groups. Moreover, evidence of inconsistent mediation indicated that single-sex testing environments negatively predicted mindset but positively predicted mathematical performance. Conclusions: These findings suggest that single-sex testing environments may represent a practical intervention to alleviate stereotype threat effects but may have a paradoxical effect on mindset.
Nutritional factors and immune functions of gut epithelium

The intestinal epithelium acts as a barrier to the external environment contained within the lumen of the gut. It also transports solutes for nutrition and for immunological surveillance. The present review develops the hypothesis that changes in diet, through the composition of the lumen environment, alter the expression of genes in the epithelium. These genes include those that encode for proteins that signal to the mucosal immune system. Directly changing the expression of signalling molecules in the intestinal epithelium using transgenic techniques alters immune function. For example, up regulation of the chemokine macrophage inflammatory protein-2 increases neutrophil recruitment. Furthermore, lumen molecules such as short-chain fatty acids regulate chemokine expression by epithelial cells. By this means, the epithelium acts as a transducing monolayer signalling between the contents of the intestine and the mucosal immune system.
Uric acid ameliorates indomethacin‐induced enteropathy in mice through its antioxidant activity

Uric acid is excreted from blood into the intestinal lumen, yet the roles of uric acid in intestinal diseases remain to be elucidated. The study aimed to determine whether uric acid could reduce end points associated with nonsteroidal anti‐inflammatory drug (NSAID)‐induced enteropathy.
Symbolic Models for Isolated Execution Environments

Isolated Execution Environments (IEEs), such as ARM TrustZone and Intel SGX, offer the possibility to execute sensitive code in isolation from other malicious programs, running on the same machine, or a potentially corrupted OS. A key feature of IEEs is the ability to produce reports binding cryptographically a message to the program that produced it, typically ensuring that this message is the result of the given program running on an IEE. We present a symbolic model for specifying and verifying applications that make use of such features. For this we introduce the S`APIC process calculus, that allows to reason about reports issued at given locations. We also provide tool support, extending the SAPIC/TAMARIN toolchain and demonstrate the applicability of our framework on several examples implementing secure outsourced computation (SOC), a secure licensing protocol and a one-time password protocol that all rely on such IEEs.
Targeted embolization reduces hemorrhage complications in partially embolized cerebral AVM combined with gamma knife surgery

This study investigated the effect and safety of targeted embolization in partially embolized cerebral arteriovenous malformation (AVM) followed by gamma knife surgery (GKS). We retrospectively analyzed 86 AVM patients who were targeted embolized by Onyx followed by GKS for residual nidus. Embolization-related complications were collected and the clinical effect was evaluated. During targeted embolization, intranidus or hemodynamic aneurysms and AVM-related fistula were evaluated and targeted embolized. Patients with AVM-related aneurysms and fistula were divided into a targeted embolization group and non-targeted embolization group based on the retrospectively determined treatment strategy. The effect of targeted embolization on hemorrhage risk was evaluated. The overall annual hemorrhage rate was 1.66% with 2.26% for ruptured AVMs and 1.08% for unruptured lesions. The annual mortality rate was 0.4%. Only one in 16 patients with embolization-related complications had permanent neurologic deficit. Twenty-four of 29 cases with intranidus aneurysms were targeted embolized, four of five cases with hemodynamic aneurysms were targeted embolized and eight of nine cases with arteriovenous fistula were targeted embolized. Chi square results showed the hemorrhage complications in the target embolization group were significantly lower than those in the non-target embolization group (p < 0.01). Targeted embolization combined with GKS treatment decreased the annual hemorrhage rate and improved clinical outcome with low permanent complications in partially embolized AVMs. This method could be proposed for the treatment of large brain AVMs when a single-technique treatment is not feasible.
The choline requirement of broiler chicks during the seventh week of life.

Male crossbred chicks were used to quantify the choline requirement and choline-sparing value of methionine and betaine for broiler chicks during the seventh week of life. The sulfur amino acid (SAA) requirement of male and female chicks was also determined. In all assays a crystalline amino acid diet containing 14.9% protein equivalent and 3400 kcal. M.E. /kg, was employed. Increasing increments (0.08%) of SAA (equal mixture of DL-methionine and L-cystine) were fed from 0.38 to 0.70% of the diet. Least squares analysis indicated SAA requirements for maximal weight gain of 0.61 and 0.62% of the diet for males and females, respectively. The choline requirement was determined by feeding six levels of choline in the presence of 0.62% SAA. Gain but not gain/feed responded linearly to choline addition. Least squares analysis of gain indicated a dietary choline requirement of 358 p.p.m. of 30.6 mg. /day. The choline-replacement value of methionine and betaine was found to be minimal.
DEVELOPMENT OF IN SITU GELLING AND MUCOADHESIVE MEBEVERINE HYDROCHLORIDE SOLUTION FOR RECTAL ADMINISTRATION

,An investigation of the ethanolic extract of the pods of Albizzia lebbeck (L.) Benth. afforded a Mebeverine hydrochloride (MbHCl) is well known to suffer from extensive first pass effect. In an attempt to improve its bioavailability and possibility restrict its absorption to only the lower rectum, rectal solution with gelation at temperature range of 30-37C o . Mixtures of poloxamer 407 (P407) and poloxamer 188 (P188) were used to confer the temperature-sensitive gelation property. To modulate the gel strength and the mucoadhesive force of MbHCl poloxamer rectal solution, mucoadhesive polymers such as hydroxypropylmethyl cellulose (HPMC), hydroxyethyl cellulose (HEC), methyl cellulose (MC) and polyvinylpyrrolidone K-25 (PVP K-25) were investigated. Incorporation of 10% w/w MbHCl in the rectal solution increased the gelation temperature of the poloxamers mixtures, while the addition of the mucoadhesive polymers had a reverse effect. On the other hand, these polymers reinforced the gel strength and the mucoadhesive force of the prepared solutions. The effect was most pronounced with MC. Increasing the concentration of cellulosic bioadhesive polymers retarded the release of MbHCl from the poloxamer solutions to different extents, and it was possible to sustain the drug effect over a period of 8 hours. PVP K-25 had no effect on drug release. Pretreatment of guinea pigs with MbHCl rectal solution [P407/ P188/ MC/ MbHCl (23/ 7/ 1.5/ 10% w/w)], having satisfactory gel strength, mucoadhesive properties and acceptable sustained release profile with zero order release kinetics, showed a significant extended spasmolytic effect to spasmogens-induced contractions on guinea pig ileum and did not cause any histological damage to the rectal tissues.
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

Background Bile acids (BAs) regulate cells by activating nuclear and membrane‐bound receptors. G protein coupled bile acid receptor 1 (GpBAR1) is a membrane‐bound G‐protein‐coupled receptor that can mediate the rapid, transcription‐independent actions of BAs. Although BAs have well‐known actions on motility and secretion, nothing is known about the localization and function of GpBAR1 in the gastrointestinal tract.
On a piecewise linear enclosure method of continuous functions of many variables

In this paper theorem of an algebraic identity that rewrites a product of n variables as additions of n th power functions is introduced. Theorem of a representation of continuous functions of many variables is provided as an application of theorem of the algebraic identity. Theorem of piecewise linear (PWL) enclosures (having representable lower and upper bounds) of continuous functions is provided as an application of theorem of the representation. Further the examples of PWL enclosures of polynomials are illustrated for imagining the application of these theorems in rigorously analyzing nonlinear systems, e.g., modeling methodology of a piecewise linear differential inclusion describing a nonlinear system dynamics.
The carbon balance of North American wetlands

We examine the carbon balance of North American wetlands by reviewing and synthesizing the published literature and soil databases. North American wetlands contain about 220 Pg C, most of which is in peat. They are a small to moderate carbon sink of about 49 Tg C yr−1, although the uncertainty around this estimate is greater than 100%, with the largest unknown being the role of carbon sequestration by sedimentation in freshwater mineral-soil wetlands. We estimate that North American wetlands emit 9 Tg methane (CH4) yr−1; however, the uncertainty of this estimate is also greater than 100%. With the exception of estuarine wetlands, CH4 emissions from wetlands may largely offset any positive benefits of carbon sequestration in soils and plants in terms of climate forcing. Historically, the destruction of wetlands through land-use changes has had the largest effects on the carbon fluxes and consequent radiative forcing of North American wetlands. The primary effects have been a reduction in their ability to sequester carbon (a small to moderate increase in radiative forcing), oxidation of their soil carbon reserves upon drainage (a small increase in radiative forcing), and reduction in CH4 emissions (a small to large decrease in radiative forcing). It is uncertain how global changes will affect the carbon pools and fluxes of North American wetlands. We will not be able to predict accurately the role of wetlands as potential positive or negative feedbacks to anthropogenic global change without knowing the integrative effects of changes in temperature, precipitation, atmospheric carbon dioxide concentrations, and atmospheric deposition of nitrogen and sulfur on the carbon balance of North American wetlands.
Nanosuspensions in Nanobiomedicine

The tremendous success in developing new nanomaterials and fostering technological innovation arises from the focus on interdisciplinary research and collaboration between physical and medical scientists. The concept of nano-medicine is one of the most important and exciting ideas ever generated by the applications of nanoscience. One of the most challenging tasks in the pharmaceutical industry is the formulation of poorly soluble drugs. The implication of conventional techniques for improving the solubility has gained limited success. Nanoparticles facilitate formulation with improved solubility and efficacy mainly through nanosuspension approach. Techniques such as media milling, high-pressure homogenization, and use of microemulsion have been used for production of nanosuspensions for a novel delivery system. Moreover, they are manoeuvred to patient-acceptable dosage forms like tablets, capsules, and lyophilized powder products. Nanosuspension technology has also been studied for active and passive targeted drug delivery systems, which the chapter highlights on various formulational perspectives and applications as a biomedicine delivery system.
A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development

Patterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of the morphogenetic furrow (MF), a moving signaling wave that sweeps across the tissue from the posterior to the anterior side, that induces proliferating cells anterior to it to differentiate and become cell cycle quiescent in its wake. Therefore, final eye disc size depends on the proliferation rate of undifferentiated cells and on the speed with which the MF sweeps across the eye disc. We developed a spatio-temporal model of the growing eye disc based on the regulatory interactions controlled by the signals Decapentaplegic (Dpp), Hedgehog (Hh) and the transcription factor Homothorax (Hth) and explored how the signaling patterns affect the movement of the MF and impact on eye disc growth. We used published and new quantitative data to parameterize the model. In particular, two crucial parameter values, the degradation rate of Hth and the diffusion coefficient of Hh, were measured. The model is able to reproduce the linear movement of the MF and the termination of growth of the primordium. We further show that the model can explain several mutant phenotypes, but fails to reproduce the previously observed scaling of the Dpp gradient in the anterior compartment.
IntNetLncSim: an integrative network analysis method to infer human lncRNA functional similarity

Increasing evidence indicated that long non-coding RNAs (lncRNAs) were involved in various biological processes and complex diseases by communicating with mRNAs/miRNAs each other. Exploiting interactions between lncRNAs and mRNA/miRNAs to lncRNA functional similarity (LFS) is an effective method to explore function of lncRNAs and predict novel lncRNA-disease associations. In this article, we proposed an integrative framework, IntNetLncSim, to infer LFS by modeling the information flow in an integrated network that comprises both lncRNA-related transcriptional and post-transcriptional information. The performance of IntNetLncSim was evaluated by investigating the relationship of LFS with the similarity of lncRNA-related mRNA sets (LmRSets) and miRNA sets (LmiRSets). As a result, LFS by IntNetLncSim was significant positively correlated with the LmRSet (Pearson correlation γ2=0.8424) and LmiRSet (Pearson correlation γ2=0.2601). Particularly, the performance of IntNetLncSim is superior to several previous methods. In the case of applying the LFS to identify novel lncRNA-disease relationships, we achieved an area under the ROC curve (0.7300) in experimentally verified lncRNA-disease associations based on leave-one-out cross-validation. Furthermore, highly-ranked lncRNA-disease associations confirmed by literature mining demonstrated the excellent performance of IntNetLncSim. Finally, a web-accessible system was provided for querying LFS and potential lncRNA-disease relationships: http://www.bio-bigdata.com/IntNetLncSim.
Progression of aflatoxicosis in broiler chickens.

The progression of aflatoxicosis was evaluated in young broiler chickens (Hubbard X Hubbard). The experimental design consisted of four dietary treatments of aflatoxin (0, 1.25, 2.5, and 5.0 micrograms of aflatoxin/g of feed, ppm) and 11 replicates of 10 broilers/replicate. The broilers were maintained in electrically heated batteries with feed and water available ad libitum from hatching to 3 weeks of age. The broilers were weighed, bled, killed by cervical dislocation, and necropzied at 3, 6, 9, 12, 15, 17, and 21 days of age. Body weights were significantly decreased by 5.0 ppm aflatoxin at 6 days of age and by 2.5 ppm at 17 days of age. Aflatoxin induced a significant increase in the relative weight of the proventriculus, gizzard, spleen, and kidney. Liver atrophy was indicated in the early stages of aflatoxicosis by a decrease in the relative weight of this organ. As aflatoxicosis progressed, hepatomegaly became apparent due to lipid accumulation in the liver. Packed-cell volume and hemoglobin levels were significantly decreased by 5.0 ppm aflatoxin at 12 days and by 2.5 ppm aflatoxin at 21 days of age. Serum levels of albumin and total protein were significantly reduced at 5.0 and 2.5 ppm aflatoxin by 3 and 6 days of age, respectively. Serum levels of uric acid, triglycerides, and cholesterol were significantly decreased from control values from 12 through 21 days of age by 5.0 ppm aflatoxin and, to a lesser extent, by 2.5 ppm aflatoxin. The activity of serum lactic dehydrogenase was significantly decreased at all aflatoxin treatment levels from 12 through 21 days of age. (ABSTRACT TRUNCATED AT 250 WORDS)
Classification of Alzheimer's Disease, Mild Cognitive Impairment, and Cognitively Unimpaired Individuals Using Multi-feature Kernel Discriminant Dictionary Learning

Accurate classification of either patients with Alzheimer's disease (AD) or patients with mild cognitive impairment (MCI), the prodromal stage of AD, from cognitively unimpaired (CU) individuals is important for clinical diagnosis and adequate intervention. The current study focused on distinguishing AD or MCI from CU based on the multi-feature kernel supervised within-Class-similar discriminative dictionary learning algorithm (MKSCDDL), which we introduced in a previous study, demonstrating that MKSCDDL had superior performance in face recognition. Structural magnetic resonance imaging (sMRI), fluorodeoxyglucose (FDG) positron emission tomography (PET), and florbetapir-PET data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were all included for classification of AD vs. CU, MCI vs. CU, as well as AD vs. MCI (113 AD patients, 110 MCI patients, and 117 CU subjects). By adopting MKSCDDL, we achieved a classification accuracy of 98.18% for AD vs. CU, 78.50% for MCI vs. CU, and 74.47% for AD vs. MCI, which in each instance was superior to results obtained using several other state-of-the-art approaches (MKL, JRC, mSRC, and mSCDDL). In addition, testing time results outperformed other high quality methods. Therefore, the results suggested that the MKSCDDL procedure is a promising tool for assisting early diagnosis of diseases using neuroimaging data.
Reconsidering the relation between serum homocysteine and red blood cell distribution width: a cross-sectional study of a large cohort

Abstract Purpose: In a recent small sample study, red blood cell distribution width (RDW) was suggested as a predictor of homocysteine levels. The current study was aimed to reexamine this association in a large scale sample. Methods: A retrospective cross-sectional study of healthy adults, conducted at Rabin Medical Center, during 2000–2014. Data were retrieved from the medical charts and a logistic regression controlling for interfering factors was carried out. Sensitivity analysis was implemented by exclusion of individuals with anaemia. Results: Five thousand, five hundred fifty-four healthy individuals were included. Mean serum homocysteine level was 10.10 (SD 2.72) μmol/L. 34.4% of the study population had a homocysteine level higher than the upper limit of normal (10.8 μmol/L). Homocysteine showed no association with RDW (OR 1.00; 95% CI 0.97–1.03), but increased with age (OR 1.05; 95% CI 1.04–1.06) and decreased with a rise in haemoglobin (OR 0.77; 95% CI 0.71–0.83), and in the mean corpuscular volume (OR 0.86; 95% CI 0.85–0.88). Exclusion of individuals with anaemia did not reveal an association between homocysteine and RDW but found a somewhat smaller association between haemoglobin and RDW [OR 0.82; 95% CI 0.73–0.91]. Conclusions: In our large scale sample we did not find an association between RDW and serum homocysteine.