Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term Remission Over Six Years for a Patient with Recurrent Glioblastoma Treated with Cediranib/Lomustine

Cediranib is an orally available, pan-VEGFR tyrosine kinase inhibitor. A previous Phase III study of patients with recurrent glioblastoma treated with this drug did not meet the primary end of progressive-free survival (PFS). We identified one patient, a 57-year-old Caucasian female who, following surgery in October 2008 and concurrent temozolomide and radiation therapy from November 8, 2008, to January 6, 2009, developed a tumor progression of the left posterior frontal measuring 1.2 x 1.5 cm in February 2009. She was enrolled in a randomized, Phase III, placebo-controlled, partially-blinded clinical trial of cediranib as either monotherapy or in combination with lomustine (CCNU) versus CCNU. She was randomized to receive a combination therapy with 1st cycle CCNU 190 mg and cediranib 20 mg per day on April 15, 2009. However, she developed nephrotic syndrome and uncontrolled hypertension and was taken off this study in May 2010. Her six-week MRI showed a 50% tumor regression and a complete response at twenty-four weeks. With no enhancement seen on MRI on June 4, 2015, she has been off therapy and in clinical remission over five years with high functional level and good quality of life (KPS-90%). This is a case report of successful therapy for recurrent glioblastoma with long-term remission despite termination of therapy greater than six years from cediranib and limited CCNU dosage.
Intrinsic Period and Light Intensity Determine the Phase Relationship between Melatonin and Sleep in Humans

The internal circadian clock and sleep-wake homeostasis regulate the timing of human brain function, physiology, and behavior so that wakefulness and its associated functions are optimal during the solar day and that sleep and its related functions are optimal at night. The maintenance of a normal phase relationship between the internal circadian clock, sleep-wake homeostasis, and the light-dark cycle is crucial for optimal neurobehavioral and physiological function. Here, the authors show that the phase relationship between these factors—the phase angle of entrainment (ψ)—is strongly determined by the intrinsic period (τ) of the master circadian clock and the strength of the circadian synchronizer. Melatonin was used as a marker of internal biological time, and circadian period was estimated during a forced desynchrony protocol. The authors observed relationships between the phase angle of entrainment and intrinsic period after exposure to scheduled habitual wakefulness-sleep light-dark cycle conditions inside and outside of the laboratory. Individuals with shorter circadian periods initiated sleep and awakened at a later biological time than did individuals with longer circadian periods. The authors also observed that light exposure history influenced the phase angle of entrainment such that phase angle was shorter following exposure to a moderate bright light (~450 lux)–dark/wakefulness-sleep schedule for 5 days than exposure to the equivalent of an indoor daytime light (~150 lux)–dark/wakefulness-sleep schedule for 2 days. These findings demonstrate that neurobiological and environmental factors interact to regulate the phase angle of entrainment in humans. This finding has important implications for understanding physiological organization by the brain’s master circadian clock and may have implications for understanding mechanisms underlying circadian sleep disorders.
Impaired energy homeostasis in C/EBP alpha knockout mice

Mice homozygous for the targeted deletion of the c/ebp alpha gene, which expresses the CCAAT/enhancer-binding protein alpha (C/EBP alpha), did not store hepatic glycogen and died from hypoglycemia within 8 hours after birth. In these mutant mice, the amounts of glycogen synthase messenger RNA were 50 to 70 percent of normal and the transcriptional induction of the genes for two gluconeogenic enzymes, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, was delayed. The hepatocytes and adipocytes of the mutant mice failed to accumulate lipid and the expression of the gene for uncoupling protein, the defining marker of brown adipose tissue, was reduced. This study demonstrates that C/EBP alpha is critical for the establishment and maintenance of energy homeostasis in neonates.
BiCross : A Biclustering Technique for Gene Expression Data using One Layer Fixed Weighted Bipartite Graph Crossing Minimization

has become an important data mining technique for microarray gene expression analysis and profiling, as it provides a local view of the hidden relationships in data, unlike a global view provided by conventional clustering techniques. This technique, in contrast to the conventional clustering techniques, helps in identifying a subset of the genes and a subset of the experimental conditions that together exhibit co related pattern. In this paper, a biclustering technique using weighted crossing minimization paradigm is proposed, which can mine significant patterns by employing a local search instead of a global search of the input data matrix. We present the novel idea of modelling the gene expression data as a weighted bipartite graph between genes and experimental conditions in order to rearrange the vertices in one layer of this graph. Using this model, an efficient biclustering technique is developed that can mine different types of biclusters and works well in practice for simulated and real world data. The experimental results demonstrate that, our method is scalable to practical gene expression data and has superiority over other similar algorithms in terms of accuracy and computational efficiency.
Cloud Armor: Protecting Cloud Commands from Compromised Cloud Services

Infrastructure-as-a-Service (IaaS) clouds can be viewed as distributed systems of cloud services that are entrusted to execute users' cloud commands to provision and manage clouds computing resources (e.g., VM). However, recent vulnerabilities found in cloud services show that this trust is often misplaced. By exploiting a vulnerability in a cloud service, an adversary can hijack or forge commands to modify user VMs, exfiltrate sensitive information, and even modify other service hosts. This paper introduces Cloud Armor, a system that detects and blocks the tampering of user commands without the need for modifications to cloud services. Our insight is that we can construct state machine models to limit the system call sequences executed by cloud services. By applying constraints over system call arguments, we can restrict the way user commands are executed, blocking unauthorized operations from compromised cloud services. We implemented a prototype Cloud Armor system for Open Stack, a widely adopted open source cloud platform. Results show that Cloud Armor can greatly limit attack options available for adversaries while imposing less than 1% overhead for user VMs. As a result, cloud users can leverage Cloud Armor to execute user commands safely even in presence of compromised cloud services.
Study on the Tribological Characteristics of Australian Native First Generation and Second Generation Biodiesel Fuel

Biodiesels are a renewable energy source, and they have the potential to be used as alternatives to diesel fuel. The aim of this study is to investigate the wear and friction characteristics of Australian native first generation and second generation biodiesels using a four-ball tribo tester. The biodiesel was produced through a two-step transesterification process and characterized according to the American Society for Testing and Materials (ASTM) standards. The tribological experiment was carried out at a constant 1800 rpm and different loads and temperatures. In addition, the surface morphology of the ball was tested by scanning electron microscope (SEM)/energy dispersive X-ray spectroscopy (EDX) analysis. The test results indicated that biodiesel fuels have a lower coefficient of frictions (COF) and lower wear scar diameter (WSD) up to 83.50% and 41.28%, respectively, compared to conventional diesel fuel. The worn surface area results showed that biodiesel fuel has a minimum percentage of C and O, except Fe, compared to diesel. In addition, the worn surface area for diesel was found (2.20%–27.92%) to be higher than biodiesel. The findings of this study indicated that both first and second generation biodiesel fuels have better tribological performance than diesel fuel, and between the biodiesel fuels, macadamia biodiesel showed better lubrication performance.
Switching Mature Retinal Ganglion Cells to a Robust Growth State In Vivo: Gene Expression and Synergy with RhoA Inactivation

The inability of mature CNS neurons to regenerate injured axons has been attributed to a loss of inherent growth potential of cells and to inhibitory signals associated with myelin and the glial scar. The present study investigated two complementary issues: (1) whether mature CNS neurons can be stimulated to alter their gene expression profile and switch into a strong growth state; and (2) whether inactivating RhoA, a convergence point for multiple inhibitory signals, is sufficient to produce strong regeneration even without activating the growth state of neurons. In the mature rat, retinal ganglion cells (RGCs) normally fail to regenerate axons through the injured optic nerve but can be stimulated to do so by activating macrophages in the eye (e.g., by lens injury). To investigate underlying changes in gene expression, we retrogradely labeled RGCs with a fluorescent dye, performed optic nerve surgery with or without lens injury, and 4 d later, dissociated retinas, isolated RGCs by fluorescence-activated cell sorting, and examined their profiles of gene expression using microarrays. To investigate the effects of inactivating RhoA, we transfected RGCs with adeno-associated viruses carrying a gene for C3 ribosyltransferase. Our results show that, with appropriate stimulation, mature CNS neurons can undergo dramatic changes in gene expression comparable with those seen in regenerating neurons of the PNS, and that RhoA inactivation by itself results in moderate regeneration, and strongly potentiates axon regeneration through the mature optic nerve when the growth state of neurons is activated.
Universal Traversal Sequences for Arbitrarily Labeled Graphs

A universal traversal sequence is a deterministic walk on an edge-labeled graph that is guaranteed to visit all of the graph’s vertices. We look at the problem of constructing universal traversal sequences for arbitrarily labeled graphs and give a combinatorial construction of quasi-polynomial length universal traversal sequences for expander graphs. This is an alternative to the quasipolynomial length construction given by Nisan [5] for general graphs, which makes use of a pseudorandom generator. We also give a guarantee on the number of vertices a universal traversal sequence for a smaller graph will visit when run on a larger graph. This may allow smaller traversal sequences to be combined to give short universal traversal sequences for arbitrarily labeled graphs.
Let your enemy do the work: within–host interactions between two fungal parasites of leaf–cutting ants

Within–host competition is an important factor in host–parasite relationships, yet most studies consider interactions involving only single parasite species. We investigated the interaction between a virulent obligate entomopathogenic fungus, Metarhizium anisopliae var. anisopliae, and a normally avirulent, opportunistic fungal pathogen, Aspergillus flavus, in their leaf–cutting ant host, Acromyrmex echinatior. Surprisingly, the latter normally out–competed the former in mixed infections and had enhanced fitness relative to when infecting in isolation. The result is most probably due to Metarhizium inhibiting the host's immune defences, which would otherwise normally prevent infections by Aspergillus. With the host defences negated by the virulent parasite, the avirulent parasite was then able to out–compete its competitor. This result is strikingly similar to that seen in immunocompromised vertebrate hosts and indicates that avirulent parasites may play a more important role in host life histories than is generally realized.
NewsCATS: A News Categorization and Trading System

NewsCATS is an automated text categorization (ATC) prototype using a hand-made thesaurus to forecast intraday stock price trends from information contained in press releases. Due to a unique labeling approach and by carefully selecting the appropriate training data NewsCATS achieves a performance which is clearly superior to other ATC prototypes used for stock price trend forecasting. In this paper we describe the architecture, training, and testing of NewsCATS as well as the results of an extensive robustness analysis.
Comparative adsorption of human enteroviruses, simian rotavirus, and selected bacteriophages to soils

Virus adsorption to soils is considered to be the most important factor in removing viruses after land treatment of wastewater. Most of the studies on virus adsorption to soils have utilized poliovirus as the model system. In the present study, comparative adsorption of a number of different types and strains of human enteroviruses and bacteriophages to nine different soil types was studied. Under the experimental conditions of this study, greater than 90% of all viruses adsorbed to a sandy loam soil except echovirus types 1, 12, and 29 and a simian rotavirus (SA-11), which adsorbed to a considerably lower degree. A great deal of variability was observed between adsorption of different strains of echovirus type 1, indicating that viral adsorption to soils is highly strain dependent. Of the five phages studied, f2 and phi X174 adsorbed the least. In addition to being dependent on type and strain of virus, adsorption was found to be influenced also by type of soil. Thus, soils having a saturated pH of less than 5 were generally good adsorbers. From these results, it appears that no one enterovirus or coliphage can be used as the sole model for determining the adsorptive behavior of viruses to soils and that no single soil can be used as the model for determining viral adsorptive capacity of all soil types.
Influence of Endothelial Nitric Oxide on Adrenergic Contractile Responses of Human Cerebral Arteries

The present study was designed to investigate the influence of the endothelium and that of the L-arginine pathway on the contractile responses of isolated human cerebral arteries to electrical field stimulation (EFS) and norepinephrine. Rings of human middle cerebral artery were obtained during autopsy of 19 patients who had died 3–8 h before. EFS (1–8 Hz) induced frequency-dependent contractions that were abolished by tetrodotoxin, prazosin, and guanethidine (all at 10-6 M). The increases in tension were of greater magnitude in arteries denuded of endothelium. NG-monomethyl L-arginine (L-NMMA 10-4 M) potentiated the contractile response to EFS in artery rings with endothelium but did not influence responses of endothelium-denuded arteries. L-arginine (10-4 M) reversed the potentiating effects of L-NMMA on EFS-induced contractions. Norepinephrine induced concentration-dependent contractions, which were similar in arteries with and without endothelium or in arteries treated with L-NMMA. Indomethacin (3 × 10−6 M) had no significant effect on the contractile response to EFS or on the inhibition by L-NMMA of acetylcholine-induced relaxation. These results suggest that the contractile response of human cerebral arteries to EFS is modulated by nitric oxide mainly derived from endothelial cells; although adrenergic nerves appear to be responsible for the contraction, the transmitter involved in the release of nitric oxide does not appear to be norepinephrine. The effects of L-NMMA in this preparation appear to be due to inhibition of nitric oxide formation rather than caused by cyclooxygenase activation.
Mismatch-Based Delayed Thrombolysis: A Meta-Analysis

Background and Purpose— Clinical benefit from thrombolysis is reduced as stroke onset to treatment time increases. The use of “mismatch” imaging to identify patients for delayed treatment has face validity and has been used in case series and clinical trials. We undertook a meta-analysis of relevant trials to examine whether present evidence supports delayed thrombolysis among patients selected according to mismatch criteria. Methods— We collated outcome data for patients who were enrolled after 3 hours of stroke onset in thrombolysis trials and had mismatch on pretreatment imaging. We selected the trials on the basis of a systematic search of the Web of Knowledge. We compared favorable outcome, reperfusion and/or recanalization, mortality, and symptomatic intracerebral hemorrhage between the thrombolyzed and nonthrombolyzed groups of patients and the probability of a favorable outcome among patients with successful reperfusion and clinical findings for 3 to 6 versus 6 to 9 hours from poststroke onset. Results are expressed as adjusted odds ratios (a-ORs) with 95% CIs. Heterogeneity was explored by test statistics for clinical heterogeneity, I2 (inconsistency), and L'Abbé plot. Results— We identified articles describing the DIAS, DIAS II, DEDAS, DEFUSE, and EPITHET trials, giving a total of 502 mismatch patients thrombolyzed beyond 3 hours. The combined a-ORs for favorable outcomes were greater for patients who had successful reperfusion (a-OR=5.2; 95% CI, 3 to 9; I2=0%). Favorable clinical outcome was not significantly improved by thrombolysis (a-OR=1.3; 95% CI, 0.8 to 2.0; I2=20.9%). Odds for reperfusion/recanalization were increased among patients who received thrombolytic therapy (a-OR=3.0; 95% CI, 1.6 to 5.8; I2=25.7%). The combined data showed a significant increase in mortality after thrombolysis (a-OR=2.4; 95% CI, 1.2 to 4.9; I2=0%), but this was not confirmed when we excluded data from desmoteplase doses that were abandoned in clinical development (a-OR=1.6; 95% CI, 0.7 to 3.7; I2=0%). Symptomatic intracerebral hemorrhage was significantly increased after thrombolysis (a-OR=6.5; 95% CI, 1.2 to 35.4; I2=0%) but not significant after exclusion of abandoned doses of desmoteplase (a-OR=5.4; 95% CI, 0.9 to 31.8; I2=0%). Conclusions— Delayed thrombolysis amongst patients selected according to mismatch imaging is associated with increased reperfusion/recanalization. Recanalization/reperfusion is associated with improved outcomes. However, delayed thrombolysis in mismatch patients was not confirmed to improve clinical outcome, although a useful clinical benefit remains possible. Thrombolysis carries a significant risk of symptomatic intracerebral hemorrhage and possibly increased mortality. Criteria to diagnose mismatch are still evolving. Validation of the mismatch selection paradigm is required with a phase III trial. Pending these results, delayed treatment, even according to mismatch selection, cannot be recommended as part of routine care.
Socio-emotional correlates of a schooldog-teacher-team in the classroom

A growing number of teachers in Europe regularly take their dogs with them into the classroom. Limited research points at positive socio-emotional effects of this practice. In this study the effects of a schooldog-teacher-team on socioemotional experiences in school, depression and emotion regulation strategies were investigated in a classroom of third-graders (male n = 12, female n = 13), which had a schooldog present for 1 day per week in comparison with a control class (male n = 11, female n = 10). In contrast to the control class, the dog-class students reported a stronger improvement with regard to positive attitude toward school (repeated measures ANOVA; F = 10.769, df = 1, p = 0.002) and positive emotions related to learning (F = 4.479, df = 1, p = 0.042) over the course of the year. Since a prerequisite of all kinds of effective learning is a positive attitude and mood toward school and learning, the presence of a schooldog-teacher team thus has the potential to support learning.
Author cooperation relationship in digital publishing based on social network analysis

The social network analysis method is used to study the author cooperation relationship of the digital publishing. We selected papers from 2005 to 2014 in the CNKI series database. By determining the core authors, drawing the network diagrams and analyzing the density, centrality and clique of the network, we find some results as follows: The situation of the collaboration in all authors is not good; co-authors are basically from the same organization and the same area; each subgroup has its own characteristics. Through this study, we reveal the author cooperation relationship of the digital publishing, thereby promoting the exchange of knowledge.
Support Tools for Visual Information Management Gökhan Kutlu

Visual applications need to represent, manipulate, store, and retrieve both raw and processed visual data. Existing relational and object-oriented database systems fail to offer satisfactory visual data management support because they lack the kinds of representations, storage structures, indices, access methods, and query mechanisms needed for visual data. We argue that extensible visual object stores offer feasible and effective means to address the data management needs of visual applications. ISR4 is such a visual object store under development at the University of Massachusetts for the management of persistent visual information. ISR4 is designed to offer extensive storage and retrieval support for complex and large visual data, customizable buffering and clustering, and spatial and temporal indexing, along with a variety of multi-dimensional access methods and query languages.
Performance Evaluation for Phase-Coded Spread-Spectrum Multiple-Access Communication - Part I: System Analysis

An analysis of an asynchronous phase-coded spread-spectrum multiple-access communication system is presented. The results of this analysis reveal which code parameters have the greatest impact on communication performance and provide analytical tools for use in preliminary system design. Emphasis is placed on average performance rather than worst-case performance and on code parameters which can be computed easily.
Evaluating effectiveness of risk identification and management using organisational models

In this paper firstly we discuss an approach for supporting risk identification with the use of higher-level organizational models. We provide some intuitive metrics for extracting measures of actor criticality and vulnerability from organizational models. This helps direct risk management to areas of critical importance within organization models. Secondly, we provide details of an experiment that we conducted to evaluate our methodology. We believe our novel approach, will provide added benefits when used with other approaches to risk management during business process management, that do not reference the greater organizational context during risk assessment.