Miracle-dz/UniFAR-FTUs huggingface dataset:
Traffic sign detection as a component of an automated traffic infrastructure inventory system ∗

We study the problem of traffic sign detection in the context of traffic infrastructure inventory. The data acquired during filming the roads in Croatia is presented. Based on recent approaches, and motivated by constraints present in our data, we employ the Viola-Jones object detector for triangular warning signs detection. The detector achieves correct detection rates better than 90%, which is sufficient for our application. The false positive rate is a concern, in some cases being higher than 160%, so the causes of false positive detections are analyzed in detail. We suggest a new approach of fusing the Viola-Jones detector with a priori knowledge, in form of a sign model and geometric constraints, in order to increase the correct detection rate and decrease the false positive rate.
Maximum likelihood resolution of multi-block genotypes

We present a new algorithm for the problems of genotype phasing and block partitioning. Our algorithm is based on a new stochastic model, and on the novel concept of probabilistic common haplotypes. We formulate the goals of genotype resolving and block partitioning as a maximum likelihood problem, and solve it by an EM algorithm. When applied to real biological SNP data, our algorithm outperforms two state of the art phasing algorithms. Our algorithm is also considerably more sensitive and accurate than a previous method in predicting and identifying disease association.
High‐resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B‐cell lymphoma and its large cell variant

We studied marginal zone B‐cell lymphomas of the gastrointestinal tract including seven small cell lymphomas, eight large cell areas of composite lymphomas and 13 large cell variants using SNP array profiling. We found an increase of genomic complexity with lymphoma progression from small to large cytology, and identified gains of prominent (proto) oncogenes such as REL, BCL11A, ETS1, PTPN1, PTEN and KRAS which were found exclusively in the large cell variants. Copy numbers of ADAM3A, SCAPER and SIRPB1 were varying between the three different modes of presentation, hence suggestive for aberrations associated with progression from small to large cell lymphoma. The number of aberrations was slightly higher in the large cell part of composite lymphomas than in large cell lymphomas, suggesting that clonal selection takes place and that composite lymphomas are in a transition state. To further investigate this, we comparatively analyzed samples of two morphologically different regions of the same small cell tumor with a BIRC3‐MALT1 translocation, as well as material acquired at two different time points from one composite lymphoma. We found genomic heterogeneity in both cases, supporting the theory of competing subclones in the evolution and progression of extranodal marginal zone B‐cell lymphoma.
Optimizing the Management of High-Risk, Localized Prostate Cancer

Prostate cancer has a high prevalence and a rising incidence in many parts of the world. Although many screen-detected prostate cancers may be indolent, prostate cancer remains a major contributor to mortality in men. Therefore, the appropriate diagnosis and treatment of localized prostate cancer with lethal potential are of great importance. High-risk, localized prostate cancer has multiple definitions. Treatment options that should be individualized to each patient include observation, radical prostatectomy, external beam radiotherapy, brachytherapy, androgen deprivation, and combined modality treatment. Specific outcomes of radical prostatectomy and combined modality treatment for high-risk prostate cancer are reviewed. The rationale for extended pelvic lymphadenectomy at the time of surgery is discussed, as is the role for surgery in the setting of node-positive, high-risk disease. There is not yet a biomarker that accurately identifies lethal prostate cancer, but rigorous clinical studies have identified methods of optimizing oncologic outcomes in high-risk men.
La méthode Delphi pour définir les accords et les controverses : applications à l'innovation dans la traçabilité et dans le e-recrutement

Une innovation se consolide ou s'affaiblit en fonction des evolutions qui se manifestent a travers les differents accords et controverses. Notre objectif est ici de proposer l'utilisation de la methode Delphi, et plus precisement du Delphi argumentaire, pour analyser a la fois les accords et les controverses qui se developpent, aussi bien au niveau d'un projet qu'a un niveau plus societal. Nous presentons d'abord l'origine de la methode Delphi, la mise en œuvre d'un Delphi argumentaire et les outils quantitatifs et qualitatifs pour l'analyse des donnees. Nous detaillons ensuite deux applications de cette methode, avec comme objectif le reperage et la qualification des accords et controverses dans le developpement d'une innovation : une enquete sur les systemes de tracabilite agro-alimentaire et une enquete sur le e-Recrutement via les medias sociaux. Enfin, nous tirons trois grandes conclusions de ce travail, au niveau methodologique, theorique et managerial.
Closed-Loop Basal Insulin Delivery Over 36 Hours in Adolescents With Type 1 Diabetes

OBJECTIVE We evaluated the safety and efficacy of closed-loop basal insulin delivery during sleep and after regular meals and unannounced periods of exercise. RESEARCH DESIGN AND METHODS Twelve adolescents with type 1 diabetes (five males; mean age 15.0 [SD 1.4] years; HbA1c 7.9 [0.7]%; BMI 21.4 [2.6] kg/m2) were studied at a clinical research facility on two occasions and received, in random order, either closed-loop basal insulin delivery or conventional pump therapy for 36 h. During closed-loop insulin delivery, pump basal rates were adjusted every 15 min according to a model predictive control algorithm informed by subcutaneous sensor glucose levels. During control visits, subjects’ standard infusion rates were applied. Prandial insulin boluses were given before main meals (50–80 g carbohydrates) but not before snacks (15–30 g carbohydrates). Subjects undertook moderate-intensity exercise, not announced to the algorithm, on a stationary bicycle at a 140 bpm heart rate in the morning (40 min) and afternoon (20 min). Primary outcome was time when plasma glucose was in the target range (71–180 mg/dL). RESULTS Closed-loop basal insulin delivery increased percentage time when glucose was in the target range (median 84% [interquartile range 78–88%] vs. 49% [26–79%], P = 0.02) and reduced mean plasma glucose levels (128 [19] vs. 165 [55] mg/dL, P = 0.02). Plasma glucose levels were in the target range 100% of the time on 17 of 24 nights during closed-loop insulin delivery. Hypoglycemia occurred on 10 occasions during control visits and 9 occasions during closed-loop delivery (5 episodes were exercise related, and 4 occurred within 2.5 h of prandial bolus). CONCLUSIONS Day-and-night closed-loop basal insulin delivery can improve glucose control in adolescents. However, unannounced moderate-intensity exercise and excessive prandial boluses pose challenges to hypoglycemia-free closed-loop basal insulin delivery.
Solides non organisés: definition, implantation et plongement

Nous proposons ici un schema de representation combinatoire (et la structure de donnees naturellement associee) qui permet de traduire tout solide topologique a l'aide d'un couple de permutations agissant sur l'ensemble des sections frontieres, traduisant respectivement l'organisation des faces (resp. des aretes) autour de chaque arete (resp. face). Nous caracterisons le domaine, et les proprietes d'unicite et de non-ambiguite de ce schema. L'etude (usuellement difficile) de sa validite (plongeabilite, dans R 3 , d'un solide combinatoire donne) est resolue dans le cadre des solides combinatoires effeuillables qui sont prouves etre plongeables si et seulement si les cartes definissant les sommets du solide combinatoire sont planaires. Une classe particuliere de tels solides effeuillables est enumeree par la suite de Schroder-Etherington. L'etude de ces solides effeuillables, generalisant la notion 2D classique d'arbre, nous a conduit a definir une notion de «solide non organise» qui est au solide topologique ce qu'un graphe est a une carte
A survey on influence spreader identification in online social network

In recent years online social network is used as a marketing platform for advertisement industry for advertising their products or services to the huge volume of people in short period of time. In that Information Diffusion is a type of process in social network for predicting the future interest of people for some specific product or services. For example, a people are interested to buy any new product in online that they may prefer the same product their known person who bought the same product recently. From the above example is mentioned that the popularity of user and relationship among other user in the network. So Influence spreader identification is a key factor of the overall framework. Because of that wide interest of selecting the influence node in social network there is a need to develop models to evaluate their performance as a social influence node. In this paper is discussed the extensive survey on influence spreader identification based various methods and models with different set of metrics used in it to measure chances of nodes to become as a social influence. Along with this survey this paper is noticed the framework for influence node selection.
Possible SARS Coronavirus Transmission during Cardiopulmonary Resuscitation

Infection of healthcare workers with the severe acute respiratory syndrome–associated coronavirus (SARS-CoV) is thought to occur primarily by either contact or large respiratory droplet transmission. However, infrequent healthcare worker infections occurred despite the use of contact and droplet precautions, particularly during certain aerosol-generating medical procedures. We investigated a possible cluster of SARS-CoV infections in healthcare workers who used contact and droplet precautions during attempted cardiopulmonary resuscitation of a SARS patient. Unlike previously reported instances of transmission during aerosol-generating procedures, the index case-patient was unresponsive, and the intubation procedure was performed quickly and without difficulty. However, before intubation, the patient was ventilated with a bag-valve-mask that may have contributed to aerosolization of SARS-CoV. On the basis of the results of this investigation and previous reports of SARS transmission during aerosol-generating procedures, a systematic approach to the problem is outlined, including the use of the following: 1) administrative controls, 2) environmental engineering controls, 3) personal protective equipment, and 4) quality control.
Octrees for faster isosurface generation

The large size of many volume data sets often prevents visualization algorithms from providing interactive rendering. The use of hierarchical data structures can ameliorate this problem by storing summary information to prevent useless exploration of regions of little or no current interest within the volume. This paper discusses research into the use of the octree hierarchical data structure when the regions of current interest can vary during the application, and are not known a priori. Octrees are well suited to the six-sided cell structure of many volumes. A new space-efficient design is introduced for octree representations of volumes whose resolutions are not conveniently a power of two; octrees following this design are called branch-on-need octrees (BONOs). Also, a caching method is described that essentially passes information between octree neighbors whose visitation times may be quite different, then discards it when its useful life is over. Using the application of octrees to isosurface generation as a focus, space and time comparisons for octree-based versus more traditional “marching” methods are presented.
The effect of grinding and/or airborne-particle abrasion on the bond strength between zirconia and veneering porcelain: a systematic review

Abstract Objective: The aim of the study was to make an inventory of current literature on the bond strength between zirconia and veneering porcelain after surface treatment of zirconia by grinding with diamond bur and/or with airborne-particle abrasion. Material and methods: The literature search for the present review was made following recommended guidelines using acknowledged methodology on how to do a systematic review. The electronic databases PubMed, Cochrane Library, and Science Direct were used in the present study. Results: Twelve studies were selected. Test methods used in the original studies included shear bond strength (SBS) test, tensile bond strength test, and micro-tensile bond strength test. The majority of studies used SBS. Results showed a large variation within each surface treatment of zirconia, using different grain size, blasting time, and pressure. Conclusions: Airborne-particle abrasion might improve the bond strength and can therefore be considered a feasible surface treatment for zirconia that is to be bonded. Grinding has been recommended as a surface treatment for zirconia to improve the bond strength; however, this recommendation cannot be verified. A standardized test method and surface treatment are required to be able to compare the results from different studies and draw further conclusions.
An Unsupervised Particle Swarm Optimization Approach for Opinion Clustering

Supervised machine learning (ML) and lexicon-based are the most frequent approaches for opinion mining (OM), but they require considerable effort for preparing the training data and to build the opinion lexicon, respectively. This paper presents two unsupervised approaches for OM based on Particle Swarm Optimization (PSO). The PSO-based approaches were evaluated by eighteen experiments with different corpora types, domains, language, class balancing and pre-processing techniques. The proposed approaches achieved better accuracy on twelve experiments. Best results were obtained on corpora with a reduced number of dimensions and for specific domains. Best accuracy (0.79) was obtained by Discrete IDPSO on the OBCC corpus, outperforming supervised ML and lexicon-based approaches for this corpus.
Molecular pathogenesis of sporadic prion diseases in man

The yeast, fungal and mammalian prions determine heritable and infectious traits that are encoded in alternative conformations of proteins. They cause lethal sporadic, familial and infectious neurodegenerative conditions in man, including Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), kuru, sporadic fatal insomnia (SFI) and likely variable protease-sensitive prionopathy (VPSPr). The most prevalent of human prion diseases is sporadic (s)CJD. Recent advances in amplification and detection of prions led to considerable optimism that early and possibly preclinical diagnosis and therapy might become a reality. Although several drugs have already been tested in small numbers of sCJD patients, there is no clear evidence of any agent’s efficacy. Therefore, it remains crucial to determine the full spectrum of sCJD prion strains and the conformational features in the pathogenic human prion protein governing replication of sCJD prions. Research in this direction is essential for the rational development of diagnostic as well as therapeutic strategies. Moreover, there is growing recognition that fundamental processes involved in human prion propagation – intercellular induction of protein misfolding and seeded aggregation of misfolded host proteins – are of far wider significance. This insight leads to new avenues of research in the ever-widening spectrum of age-related human neurodegenerative diseases that are caused by protein misfolding and that pose a major challenge for healthcare.
Multi-Level Cache

Hardware designers are constantly looking for ways to squeeze waste out of architectures to achieve better power e fficiency. Cache resizing is a technique that can remove waste ful power consumption in caches. The idea is to determine the minimum cache a program needs to run at near-peak performance, and then reconfigure the cache to implement this efficient capacity. While there has been significant previou s work on cache resizing, existing techniques have focused on controlling resizing for a single level of cache only. This s acrifices significant opportunities for power savings in moder n CPU hierarchies which routinely employ 3 levels of cache. This paper investigates multi-level cache resizing(MCR). MCR independently resizes all caches in a modern cache hierarchy to minimize dynamic and static power consumption at all caching levels simultaneously. Specifically, we stud y a static-optimal version of MCR, and find resizing a 3-level hierarchy can reduce total energy dissipation by 58.9% with only 4.4% degradation in performance. Our study shows a non-trivial portion of this gain–1 3rd for programs exhibiting good temporal locality–comes from optimizing the interactions between resizing decisions at different caching leve ls. We also propose several dynamic resizing algorithms that ca n automatically find good size configurations at runtime. Our results show dynamic MCR can achieve between 40–62% energy savings with slightly higher performance degradation than static-optimal MCR.
LA ENSEÑANZA DE LA PSICOLOGÍA GENÉTICA Y LOS PROCESOS DE CAMBIO CONCEPTUAL.

Como docentes de la Catedra de Psicologia Genetica de la UNLP, desarrollamos nuestras practicas de ensenanza desde la perspectiva del constructivismo en contexto (Lenzi, 1998, 2001). Asumimos que los estudiantes elaboran teorias ingenuas especificas sobre como se conoce y que papel juega el sujeto en ese proceso, y que desde estas teorias o marcos asimiladores interpretan los contenidos a trabajar. El objetivo de este trabajo es mostrar las posibilidades de modificacion en las definiciones de los conceptos de asimilacion, acomodacion y Objeto de estudio de la Psicologia Genetica. Para ello, analizamos las definiciones sobre los conceptos mencionados que elaboraron 118 estudiantes que desaprobaron el primer examen parcial de la materia, y las comparamos con sus producciones en la instancia recuperatoria, para constatar los posibles cambios en sus conceptualizaciones. Los resultados muestran que las mayores dificultades se encuentran tanto en la definicion como en las posibilidades de modificacion del concepto de acomodacion, que suele comprenderse como algo que le “sucede” al objeto, o como un mecanismo posterior a la asimilacion, evidenciando una “teoria intuitiva” lineal, cuantitativa y no dialectica del desarrollo cognitivo. Consideramos que este tipo de analisis brinda informacion relevante al momento de pensar estrategias posibles para la ensenanza. Palabras clave Psicologia Genetica Cambio conceptual ABSTRACT TEACHING GENETIC PSYCHOLOGY AND THE CONCEPTUAL CHANGE PROCESSES As professors of the Chair of Genetic Psychology in the UNLP, we develop our teaching practices from the contextual constructivism’s perspective. We assume that students elaborate specific naive theories regarding how we attain knowledge and what part does the subject play in this process, and that from these theories or assimilating frameworks they interpret the contents to work on. The main aim of this work is to show the possibilities of modification in the definitions of the concepts of assimilation, accommodation and the Object of study of Genetic Psychology. To this end, we have analyzed the definitions regarding the above mentioned concepts elaborated by 118 students who failed the subject’s first partial examination. We have henceforth compared these responses with the corresponding ones at the recovery stage to ascertain possible changes in conceptualization. The results show that the most important difficulties are found in the definition as well as in the possibilities of modification of the concept of accommodation, which is usually considered as something that “happens” to the object, like a mecanism that follows the assimilation, making apparent a lineal, quantitative and non dialectical “intuitive theory” of cognitive development. We consider that this kind of analysis provides relevant information to develop possible strategies for teaching. Key words Genetic Psychology Conceptual change
Optimized workflow for US/MeVis-CT based registration in image guided liver surgery

In order to utilize the concept of image-guided surgery during liver surgery, a fast and locally accurate patient-to-image registration workflow using ultrasound (US) and MeVis-CT data was developed. The method was applied during the surgery of six patients and available accuracy was identified. We present here the framework, the required time as well as the navigation accuracy reached.
An Improved Algorithm for Bipartite Correlation Clustering

Bipartite Correlation clustering is the problem of generating a set of disjoint bi-cliques on a set of nodes while minimizing the symmetric dierence to a bipartite input graph. The number programs which become prohibitive even for modestly sized tasks. In this paper we present an improved factor 4 ap- proximation algorithm to this problem using a simple combinatorial algorithm which does not require solving large convex programs. The analysis extends a method developed by Ailon, Charikar and Alantha in 2008, where a randomized pivoting algorithm was analyzed for obtaining a 3-approximation algorithm for Correlation Clustering, which is the same problem on graphs (not bipartite). The analysis for Correlation Clustering there required dening events for structures containing 3 vertices and
Surface reconstruction, one triangle at a time

A new algorithm is presented for surface reconstruction from unorganized points. Unlike many existing methods, this algorithm does not select a subcomplex of the Delaunay Triangulation of the points. Instead, it uses an incremental technique, adding one triangle of the surface at a time. As a result, the algorithm does not require the surface’ s embedding space to be ; the dimension of the embedding space may vary arbitrarily without substantially affecting the complexity of the algorithm. A wider variety of surfaces may therefore be reconstructed, including the class of non-orientable surfaces, such as the Klein Bottle. The algorithm is of an experimental character; while it is motivated from geometric and topological intuition, no proofs of homeomorphism are given. Instead, its efficac y is demonstrated from the point of view of correct experimental reconstruction of surfaces of varying genus.
Empowering Processes and Outcomes of Participation in Online Support Groups for Patients With Breast Cancer, Arthritis, or Fibromyalgia

Ever since the rise of online support groups it has been presumed that there is an empowering effect from patients' participating in these groups, despite a lack of evidence to back up this assumption. In this study we explored if, and in which ways, patients feel empowered by participation. Additionally, we studied which empowering and disempowering processes occur as a result of taking part in these groups. To accomplish this aim, we interviewed 32 participants of online support groups. This analysis revealed the following empowering processes: exchanging information, encountering emotional support, finding recognition, sharing experiences, helping others, and amusement. Disempowering processes were mentioned far less often. Empowering outcomes mentioned were being better informed; feeling confident in the relationship with their physician, their treatment, and their social environment; improved acceptance of the disease; increased optimism and control; enhanced self-esteem and social well-being; and collective action. This article demonstrates that participation in online support groups can make a valuable contribution to the emergence of empowered patients.