Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Acoustic and Tactile Multi-Modal Stimulation on Objective and Subjective Measures of Permanent Intractable Tinnitus: A Prospective Research Study

Tinnitus is a complex condition comprising of three components, audiological, neurological and psychological which together produce the problems most commonly experienced by tinnitus suffers. It is believed that brainstem structures, such as cochlear nuclei, play a major role in tinnitus generation and that perception occurs at the cortical level. Studies suggest that hearing-loss causes a cascade of neuropathic effects in the central hearing system that is driven by maladaptive neuroplasticity. This model is supported by Eggermont et al. (2006); Kaltenbach et al. (2005); Weisz et al. (2007) which report that tinnitus patients with an underlying hearing-loss exhibited increased spontaneous firing rates, increased synchronicity and a reorganization of tonotopic maps in the auditory brainstem and auditory cortex. Similarly, Parra & Pearlmutter (2007) reports that individuals with tinnitus were more susceptible to the Zwicker tone auditory illusion, suggesting that tinnitus may be related to a central phenomenon of frequency dependent adaptive gains in their hearing-response. Tinnitus may also partially involve the cranial somatosensory central nervous systems. Shore et al. (2005); Herraiz et al. (2007) demonstrated a functional interaction between auditory brainstem structures and input from the branches of the trigeminal nerve and that stimulation of these nerves can qualitatively and quantitatively influence tinnitus perception. Studies have shown that using Transcutaneous Electrical Nerve Stimulation (TENS) to stimulate the C2 dermatome can have a significant beneficial effect on the perception of tinnitus (Vanneste et al., 2010; Shore; 2005). We present the findings of a research study into the impact of acoustic and tactile multi-modal stimulation on objective and subjective measures of permanent intractable tinnitus. This 16-week study was conducted with 54 patients suffering from permanent intractable tinnitus. Patients demonstrated statistically significant mean improvements in Minimum Masking level (-8.6dB); Tinnitus Loudness Matching (-7.2dB); and Tinnitus Handicap Inventory (-9.4pts). We discuss the implications of these findings for the clinical treatment of tinnitus and finally we make recommendations for the continued clinical investigation of this area of research.
Logics and rationalisations underpinning entrepreneurial decision-making

Purpose The purpose of this paper is to explore the logics that expert entrepreneurs use when faced with a critical incident threat. Design/methodology/approach Attempts have been made to define “entrepreneurial logic”. This paper is influenced by Sarasvathy’s work on high-performance entrepreneurs, which finds that when faced with uncertainty entrepreneurs employ unconventional logic, and encompasses later research acknowledging social contexts where entrepreneurs operate. A typology of decision-making logics is developed, taking into account the situation of crisis. Seven expert entrepreneurs who faced crisis and, despite this, are still successfully operating businesses were interviewed. The paper develops a critical incidents methodology. Findings Experienced entrepreneurs were found to tend towards causal logic when “the stakes were high” and the decision may affect the survival of their business. They also weigh up options before acting and tend to seek advice from trusted “others” within their network before or after they have made a decision. A mixture of causal and intuitive logic is evident in decisions dealing with internal business problems. Research limitations/implications The decisions that entrepreneurs make shape and define their business and their ability to recover from crisis. If researchers can develop an understanding of how entrepreneurs make decisions – what information they draw upon, what support systems they use and the logic of their decision-making and rationalisation – then this can be used to help structure support. Originality/value By exploring decision-making through critical incidents we offer an innovative way to understand context-rich, first-hand experiences and behaviours of entrepreneurs around a focal point.
Joint use of echosounding, fishing and video techniques to assess the structure of fish aggregations around moored Fish Aggregating Devices in Martinique (Lesser Antilles)

From April 2003 to April 2004 monthly sea surveys were conducted around 2 fish aggregating devices (FADs) moored at 2000 and 2500 m depth in Martinique (Lesser Antilles). The use of a dual frequency splitbeam echosounder combined with an underwater camera and fishing methods allowed assessment of average space and time distribution of pelagic fish aggregated beneath the FADs, as well as identification of their overall size and species com- position. At daytime, 4 fish aggregations were identified at each FAD, representing 4 distinct types: i) an aggregation of small juvenile tuna (mean fork length, FL: 30 cm) observed very close to the surface in 25% of daytime periods; ii) a small surface aggregation dominated by carangids, Caranx crysos, present in 65% of daytime periods; iii) a large sub- surface aggregation observed during all daytime periods: this aggregation appeared to be primarily comprised of 58 cm FL blackfin tuna (Thunnus atlanticus), mixed with yellowfin (Thunnus albacares) and skipjack (Katsuwonus pelamis) tunas of the same size; and iv) sub-surface scattered large predators (mainly blue marlin, Makaira nigricans )p resent in 10% of daytime periods. A smaller sub-surface aggregation comprised of medium tuna mixed with "extranatants" (fishes which remain within 10 to 50 m of a FAD) was observed in 75% of night-time periods, whereas unidentified scattered fishes were detected from 70 to 400 m depth. The low daytime vulnerability of medium sub-surface tunas to applied line techniques leads us to assume that their feeding motivation was low during daytime. These tunas could pref- erentially feed on mesopelagic organisms during night-time and transition periods around Martinican moored FADs. Local fishermen mainly targeted the large scattered predators using very small tunas as living bait. The sub-surface tuna aggregation hence appeared to be currently unexploited by local fisheries, though it represented the large majority of the pelagic biomass around the moored FADs.
Approximate Nash Equilibria via Sampling

We prove that in a normal form n-player game with m actions for each player, there exists an approximate Nash equilibrium where each player randomizes uniformly among a set of O(log(m) + log(n)) pure strategies. This result induces an $N^{\log \log N}$ algorithm for computing an approximate Nash equilibrium in games where the number of actions is polynomial in the number of players (m=poly(n)), where $N=nm^n$ is the size of the game (the input size). In addition, we establish an inverse connection between the entropy of Nash equilibria in the game, and the time it takes to find such an approximate Nash equilibrium using the random sampling algorithm.
Dynamical D4-D8 and D3-D7 branes in supergravity

We present a class of dynamical solutions for intersecting D4-D8 and D3-D7 brane systems in ten-dimensional type IIA and IIB supergravity. We discuss if these solutions can be recovered in lower-dimensional effective theories for the warped compactification of a general p-brane system. It is found that an effective p+1-dimensional description is not possible in general due to the entanglement of the transverse coordinates and the p+1-dimensional coordinates in the metric components. For the D4-D8 brane system, the dynamical solutions reduces to a static warped AdS{sub 6}xS{sup 4} geometry in a certain spacetime region. For the D3-D7 brane system, we find a dynamical solution whose metric form is similar to that of a D3-brane solution. The main difference is the existence of a nontrivial dilaton configuration in the D3-D7 solution. Then we discuss cosmology of these solutions. We find that they behave like a Kasner-type cosmological solution at {tau}{yields}{infinity}, while it reduces to a warped static solution at {tau}{yields}0, where {tau} is the cosmic time.
Use of Time for Outdoor Recreation in the United States, 1965–2007

This study examines time-use for outdoor recreation during 1965 to 2007. Using data on over 47,000 individuals from six nationally representative time-use surveys, we first document time-use trends between 1965 and 2007. We then develop a two-part instrumental variable censored regression model (a hurdle model) to predict individual-level time-use. Our results show that per capita time-use in outdoor recreation has more than doubled since 1965. This long-term increase was driven largely by increased participation rate. However, in the last decade or two, per capita time-use in outdoor recreation has stayed constant or slightly decreased. This change was driven mostly by reduced time-use by active participants; participation rate has not changed considerably. Demographics, amount of leisure, and other factors all have contributed to changes over time, but their effects and relative importance vary between participation, time-use per active participant, and time periods.
Identification of Biomarkers for Footpad Dermatitis Development and Wound Healing

Footpad dermatitis (FPD) is a type of skin inflammation that causes necrotic lesions on the plantar surface of the footpads in commercial poultry, with significant animal welfare, and economic implications. To identify biomarkers for FPD development and wound healing, a battery cage trial was conducted in which a paper sheet was put on the bottom of cages to hold feces to induce FPD of broilers. Day-of-hatch Ross 308 male broiler chicks were fed a corn–soybean meal diet and assigned to 3 treatments with 8 cages per treatment and 11 birds per cage. Cages without paper sheets were used as a negative control (NEG). Cages with paper sheets during the entire growth period (d 0–30) were used as a positive control (POS) to continually induce FPD. Cages with paper sheets during d 0–13 and without paper sheets during d 14–30 were used to examine the dynamic of FPD development and lesion wound healing (LWH). Footpad lesions were scored to grade (G) 1–5 with no lesion in G1 and most severe lesion in G5. Covering with paper sheets in POS and LWH induced 99% incidence of G3 footpads on d 13. Removing paper sheets from LWH healed footpad lesions by d 30. One representative bird, with lesions most close to pen average lesion score, was chosen to collect footpad skin samples for biomarker analysis. Total collagen protein and mRNA levels of tenascin X (TNX), type I α1 collagen (COL1A1), type III α1 collagen (COL3A1), tissue inhibitor of metalloproteinase 3 (TIMP3), and integrin α1 (ITGA1) mRNA levels were decreased (P < 0.05), while mRNA levels of tenascin C (TNC), tumor necrosis factor (TNF) α, Toll-like receptor (TLR) 4 and vascular endothelial growth factor (VEGF), IL-1β, and the ratio of MMP2 to all TIMP were increased (P < 0.03) in G3 footpads in POS and LWH compared to G1 footpads in NEG on d 14. These parameters continued to worsen with development of more severe lesions in POS. After paper sheets were removed (i.e., LWH), levels of these parameters gradually or rapidly returned to levels measured in NEG. Regression analysis indicated significant quadratic changes of these parameters to footpad lesion scores. In summary, these biomarkers were interrelated with dynamic changes of footpad lesion scores, suggesting they may be used as potential biomarkers for footpad lesion development and wound healing process.
What If A Fish Got Drunk? Exploring the Plausibility of Machine-Generated Fictions

Within the WHIM project, we study fictional ideation: processes for automatically inventing, assessing and presenting fictional ideas. Here we examine the foundational notion of the plausibility of fictional ideas, by performing an empirical study to surface the factors that affect judgements of plausibility. Our long term aim is to formalise a computational method which captures some intuitive notions of plausibility and can predict how certain types of people will assess the plausibility of certain types of fictional ideas. This paper constitutes a first firm step towards this aim.
Predictive model of load and price for restructured power system using neural network

Load and price prediction are an important component in the economic and secures operation of the competitive restructured power system energy market. This paper presents the use of an artificial neural network to half hourly ahead load prediction and half hourly ahead price prediction applications. By using historical weather, load consumption, price and calendar data, a multi-layer feed forward (FF) neural network trained with Back propagation (BP) algorithm was developed for the half hour ahead prediction. The developed algorithm for half hourly prediction has been tested with Australian market data. The result of ANN prediction model is compared with the conventional Multiple Regression (MR) prediction model.
Age of differentiation determines rat retinal germinal cell phenotype: induction of differentiation by dissociation

We are interested in the mechanisms that control cell phenotype during the development of the CNS. Since different neuronal types arise at different times during neurogenesis in the retina, we predicted that the factors that determine cell type must be developmentally regulated as well. To test this hypothesis, we induced retinal germinal cells to differentiate at different ages by dissociating the retina into single cells and culturing them on a variety of substrates. Prior to dissociation, the S-phase germinal cells were labeled with 3H-thymidine so that their fate could be specifically followed. We found that our culture conditions promoted the differentiation of the majority of the germinal cells and that these cells differentiated into different neuronal types depending on the age of the animal from which the retina had been taken; embryonic day 14 germinal cells differentiated primarily into ganglion cells, and never produced rods, while germinal cells from postnatal day 1 retina differentiated into rods, but not ganglion cells. These results are consistent with the hypothesis that temporally regulated factors determine cell phenotype during the development of the retina.
Trends in pan evaporation and actual evapotranspiration across the conterminous U.S.: Paradoxical or complementary?

Pan evaporation (ETpan) has decreased at 64% of pans in the conterminous U.S. over the past half‐century. Comparing trends in ETpan and water budget‐derived actual evapotranspiration (ET*a), we observe the so‐called “Pan Evaporation Paradox,” which we confirm is no more than a manifestation of the complementarity between actual evapotranspiration (ETa) and potential evapotranspiration (ETp). Examining trends in the components of ETa—the radiative energy and regional advective budgets—we show that both components must be considered together to explain the relationship between ETpan and ET*a.
Recurrent Plasmodium falciparum Malaria Infections in Kenyan Children Diminish T-Cell Immunity to Epstein Barr Virus Lytic but Not Latent Antigens

Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002–2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5–9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30–0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5–9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology.
Mobile agent based secure code update in wireless sensor networks

Most of the sensor nodes are battery powered and energy utilization is one of the important criteria. At the same time Securing code update is very much essential for military, health care and environmental applications. But to send the code updates in a distributed, multihop sensor networks, most of the energy will be consumed in forwarding the packets to next hop sensor nodes. In order to avoid this and save energy consumption at sensor nodes, a small number of mobile agents are used to distribute the code. Mobile agents traverse along the desired path to disseminate the code. Sensor nodes have to authenticate the mobile agent and at the same time they have to check the integrity of the packets. Mobile agents are more vulnerable for adversaries, hence measures are taken to detect the attacks and rectify them. Secure code update using mobile agents provides confidentiality and immediate authentication. This protocol is implemented on Tiny OS platform, tested using Tossim simulator and evaluated the Performance.
Generalized Volterra and Wiener nonlinear filters for applications in digital Communications

New developments in nonlinear dynamical systems are permitting Volterra and Wiener nonlinear functional series representations to be optimally approximated by artificial neural networks, which are capable of adaptation, learning and evolution by training with or without supervision.The framework based on Generalized Fock Space, enabling these developments is briefly reviewed. In particular, the realization of a best approximation to Wiener’s Laguerre / Hermite representation in terms of a dynamical functional artificial neural network (D-FANN) is presented. Applications of this technology to emerging telecommunications systems such as wireless, digital subscriber lines, and cable TV are discussed.
A Fault-Tolerant Scheduling Algorithm for Real-Time Periodic Tasks with Possible Software Faults

A hard real-time system is usually subject to stringent reliability and timing constraints. One way to avoid missing deadlines is to trade the quality of computation results for timeliness, and software fault tolerance is often achieved with the use of redundant programs. A deadline mechanism which combines these two methods is proposed to provide software fault tolerance in hard real-time periodic task systems. We consider the problem of scheduling a set of real-time periodic tasks each of which has two versions: primary and alternate. The primary version contains more functions and produces good quality results, but its correctness is more difficult to verify. The alternate version contains only the minimum required functions and produces less precise results and its correctness is easy to verify. We propose a scheduling algorithm which 1) guarantees either the primary or alternate version of each critical task to be completed in time and 2) attempts to complete as many primaries as possible. Our basic algorithm uses a fixed priority-driven preemptive scheduling scheme to preallocate time intervals to the alternates and, at runtime, attempts to execute primaries first. An alternate will be executed only if necessary because of time or bugs.
The epidemiological patterns of honour killing of women in Pakistan.

BACKGROUND Honour killing (HK) is a problem of public health concern but published data on the phenomenon are limited and many cases likely go unrecognized. Our study focuses on the epidemiological patterns of HK of women in Pakistan, where domestic violence is common and HK occurs but is poorly described. METHODS Human Rights Commission of Pakistan (HRCP) systematically collected data on HK of women using newspaper reports from January 2004 till December 2007. We analysed the aggregated data on HK through December 2007 and estimated the rates of HK. RESULTS A total of 1957 HK events occurred from 2004 to 2007; complete data was not available for all variables. Adults (>or=18 years) constituted 82% (803/978) of death toll with 88% (1257/1435) being married. Alleged extramarital relation was the major reason for the killing (92%; 1759/1902). Husbands (43%; 749/1739), brothers (24%; 421/1739) and 'other' close relatives (12%; 200/1739) were the perpetrators in known HK events. Among the weapons/methods used for killing, firearms (61%; 1071/1768), stabbing (4%; 65/1768), use of axe (12%; 220/1768), edged tool (8%;136/1768) and strangulation (9%; 167/1768) were the main means of execution. The mean annual rate of HK in females (age 15-64 years) was found to be 15.0 per million. CONCLUSIONS Newspaper reports are good source of surveillance when information is limited. We found that adult married women constituted the majority of victims of HK. Ongoing surveillance would serve to better characterize HK in Pakistan and assess the effectiveness of preventive strategies.
An Enterococcus faecium Secreted Antigen, SagA, Exhibits Broad-Spectrum Binding to Extracellular Matrix Proteins and Appears Essential for E. faecium Growth

ABSTRACT A gene encoding a major secreted antigen, SagA, was identified in Enterococcus faecium by screening an E. faecium genomic expression library with sera from patients with E. faecium-associated endocarditis. Recombinant SagA protein showed broad-spectrum binding to extracellular matrix (ECM) proteins, including fibrinogen, collagen type I, collagen type IV, fibronectin, and laminin. A fibrinogen-binding protein, purified from culture supernatants of an E. faecium clinical isolate, was found to match the N-terminal sequence of the predicted SagA protein and to react with the anti-SagA antibody, confirming that it was the SagA protein; this protein appeared as an 80- to 90-kDa smear on a Western blot that was sensitive to proteinase K and resistant to periodate treatment and glycoprotein staining. When overexpressed in E. faecium and Escherichia coli, the native and recombinant SagA proteins formed stable oligomers, apparently via their C-terminal domains. The SagA protein is composed of three domains: (i) a putative coiled-coil N-terminal domain that shows homology to the N-terminal domain of Streptococcus mutans SagA protein (42% similarity), previously shown to be involved in cell wall integrity and cell shape maintenance, and to the P45 protein of Listeria monocytogenes (41% similarity); (ii) a central domain containing direct repeats; and (iii) a C-terminal domain that is similar to that found in various proteins, including P45 (50% similarity) and P60 (52% similarity) of L. monocytogenes. The P45 and P60 proteins both have cell wall hydrolase activity, and the latter has also been shown to be involved in virulence, whereas cell wall hydrolase activity was not detected for SagA protein. The E. faecium sagA gene, like the S. mutans homologue, is located in a cluster of genes encoding proteins that appear to be involved in cell wall metabolism and could not be disrupted unless it was first transcomplemented, suggesting that the sagA gene is essential for E. faecium growth and may be involved in cell wall metabolism. In conclusion, the extracelluar E. faecium SagA protein is apparently essential for growth, shows broad-spectrum binding to ECM proteins, forms oligomers, and is antigenic during infection.