Miracle-dz/UniFAR-FTUs huggingface dataset:
Angiotensin II exerts dual actions on sodium-glucose transporter 1-mediated transport in the human jejunal mucosa

Abstract Objectives. Intestinal glucose absorption is mainly mediated via the sodium-glucose transporter 1 (SGLT1) at the apex of the enterocytes, whereas the glucose transporter 2 (GLUT2) provides a basolateral exit. It has been shown in rats that Angiotensin II (AngII), the principal mediator of renin-angiotensin system (RAS), inhibits jejunal SGLT1-mediated glucose absorption. The aim of the present study was to investigate if a similar mechanism exists also in the human jejunal mucosa. Material and methods. Enteroscopy with mucosal biopsy sampling was performed in 28 healthy volunteers. Functional assessments were performed in Ussing chambers using a pharmacological approach. Western blotting and immunohistochemistry were used to assess the presence of the AngII type 1 (AT1R) and type 2 receptor (AT2R), as well as the glucose transporters SGLT1 and GLUT2. Results. Exposure of the mucosa to 10 mM glucose elicited a ≈50% increase in the epithelium-generated current (Iep). This glucose-induced electrogenic response was sensitive to the competitive SGLT1 inhibitor phlorizin, but not to AngII when given alone. AngII combined with the AT2R blocker PD123319 markedly inhibited the response. AngII in combination with the AT1R antagonist losartan tended to increase the electrogenic response, whereas direct activation of AT2R using the agonist C21 significantly enhanced the mucosal response to glucose. The AT1R and AT2R as well as SGLT1 and GLUT2 were detected inside the human enterocytes. Conclusions. The pharmacological analysis indicated that activation of AT1R inhibits, whereas activation of AT2R enhances SGLT1-mediated glucose transport in the human jejunal mucosa.
Resistance of Thermus spp. to Potassium Tellurite

Two members of the genus Thermus were examined for their resistance to toxic inorganic compounds. They both proved to be fairly resistant to tellurite and selenite and to many other heavy metal salts. Cell extracts of Thermus thermophilus HB8 and of T. flavus AT-62 catalyze the reduction of K2TeO3 in a reaction which is dependent on NADH oxidation.
Optimal Convergence Trading Vladislav Kargin

This article examines arbitrage investment in a mispriced asset when the mispricing follows the Ornstein-Uhlenbeck process and a credit-constrained investor maximizes a generalization of the Kelly criterion. The optimal differentiable and threshold policies are derived. The optimal differentiable policy is linear with respect to mispricing and risk-free in the long run. The optimal threshold policy calls for investing immediately when the mispricing is greater than zero with the investment amount inversely proportional to the risk aversion parameter. The investment is risky even in the long run. The results are consistent with the belief that creditconstrained arbitrageurs should be risk-neutral if they are to engage in convergence trading. Myron [Scholes] once told me they are sucking up nickels from all over the world. But because they are so leveraged that amounts to a lot of money. Merton Miller about the essence of arbitrage.
Selecting multiple network spreaders based on community structure using two-phase evolutionary framework

The identification of multiple network spreaders is an appropriate solution to spread information, ideas or diseases in many practical applications. For instance, in target marketing, the spreaders are selected from customer groups classified by similar purchase behaviors to advertise the products, and to optimize the allocation of limited resources. The community detection approaches intuitively are used to identify the community structures or social groups in a social/complex network. However, how to determine the number of community K is a difficult issue. Hence, two-phase evolutionary framework (TPEF) is proposed for automatically determining the number of community K and maximizing the modularity of communities. In the preliminary experiment, the LFR benchmark networks are used to test the proposed method, and to analyze the execution time, the community quality and the network spreading effect. The experiment results show that TPEF can perform well and produce the satisfied quality of community structures. The community detection approaches can be used to assist selecting the multiple network spreaders, and to gain the benefit in network spreading when the community structure is obvious. Furthermore, our results suggest that developing an index, a mechanism or a sampling technic is necessary to decide whether the community detection approaches are applied for selecting multiple network spreaders.
Wnt5a Does Not Support Hematopoiesis in Stroma-Free, Serum-Free Cultures

Previously we reported that Wnt5a is highly expressed in the murine urogenital ridge-derived UG26-1B6 cells but not embryonic liver-derived EL08-1D2 cells. Mouse long-term repopulating hematopoietic stem cells (LTR-HSC) were maintained in non-contact UG26-1B6 cultures but not EL08-1D2 non-contact cultures, unless Wnt5a was also added to the cultures, suggesting a role for Wnt5a in the in vitro maintenance of LTR-HSC. Here, we investigated if the effect of Wnt5a on adult LTR-HSC activity is HSC-autonomous. To test the effect of Wnt5a on maintenance of LTR-HSC, we performed limiting dilution competitive transplantation assays of murine Lin-Sca1+ c-kit+ (LSK) cells cultured for 5 days with TPO and SCF with and without Wnt5a. The effect of Wnt5a on the generation of colony forming units (CFU) and the homing ability of LSK progeny was also tested. No effects were found of Wnt5a on total cell expansion, the number of CFU, or homing ability of day 5 LSK progeny. Furthermore, addition of Wnt5a did not improve, but may have impeded maintenance of LTR-HSC. In conclusion, our data indicate that Wnt5a does not enhance the maintenance and expansion of adult murine LTR-HSCs or committed progenitors cultured in vitro in serum- and stroma-free conditions.
Stepping into cooperative buildings

If we are stepping out of windows (of the GUI kind), what are we stepping into? We suggest it is into cooperative buildings. For the foreseeable future, at least, we can identify two major characteristics of the cooperative building. The spaces of the building will be augmented in various ways, providing an ambient environment that bridges spatial discontinuities in workgroups and provides a continuous window into the state of the virtual world. Secondly, the ways in which the spaces themselves are used will evolve to be more congruent with the fluid, dynamic and distributed nature of the work taking place in the building. These two characteristics are deeply interconnected. This evolution need not happen entirely in the physical world; the essence of a cooperative building will become the way in which it mixes both physical and virtual affordances to support the workaday activities of its inhabitants.
Design selection criteria for discrimination between nested models for binomial data

The aim of an experiment is often to enable discrimination between competing forms for a response model. We consider this problem when there are two competing generalized linear models (GLMs) for a binomial response. These models are assumed to have a common link function with the linear predictor of one model nested within that of the other. We consider selection of a continuous design for use in a non-sequential strategy and investigate a new criterion, TE-optimality, based on the difference in the deviances from the two models. A comparison is made with three existing design selection criteria, namely T-, Ds- and D-optimality. Issues are raised through the study of two examples in which designs are assessed using simulation studies of the power to reject the null hypothesis of the simpler model being correct, when the data are generated from the larger model. Parameter estimation for these designs is also discussed and a simple method is investigated of combining designs to form a hybrid design to achieve both model discrimination and estimation. Such a method may offer a computational advantage over the use of a compound criterion and the similar performance of the resulting designs is illustrated in an example. MSC: primary 62K05, 62J12; secondary 62K20
Intellectual Investment, Dopaminergic Gene Variation, and Life Events: A Critical Examination

Abstract Need for Cognition (NFC) and Openness to Ideas are intellectual investment traits that are characterized by a tendency to seek out, engage in and enjoy effortful cognitive activity. Little, however, is known about the extent to which they are influenced by genetic and environmental factors. With the present contribution, we aim at furthering our knowledge on the mechanisms underlying intellectual investment traits by following-up on a recent investigation of the role of dopaminergic gene variation in intellectual investment. Employing a standard approach that relied on null-hypothesis significance testing, we found that, first, two dopaminergic genetic variants interacted in modulating individual differences in NFC, but not in Openness to Ideas; that, second, negative life events played a role in the modulation of Openness to Ideas, but not of NFC; and that, third, negative life events as assessed using another measure were only marginally related to Openness to Ideas while positive life events were associated with both Openness to Ideas and NFC, with the latter effect being also dependent on DRD4 exon III genotype. However, employing a Bayesian approach, the assumption of a genetic effect on investment traits was overall not supported, while the assumption of a role of positive life events in the modulation of investment traits could be confirmed, with a tentative increment in the prediction of NFC by adding an interaction of positive life events and DRD4 variation to the main effect of positive life events. Our findings underscore the importance to use different approaches in the field of personality neuroscience. To gain deeper insight into the basis of personality traits does not only require to consider genetic as well as environmental influences and their interplay, but also requires more differentiated statistical analyses that can at least in part tackle the often inconsistent findings in this field.
Longitudinal Investigation of Methicillin‐Resistant Staphylococcus aureus in Piglets

Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as an important public health concern and pigs have been implicated in human infections. Cross‐sectional studies have demonstrated that MRSA can be commonly found in pigs internationally, but little is known about age‐related changes in MRSA colonization. This study evaluated MRSA colonization in piglets in a longitudinal manner. Serial nasal swabs were collected from piglets born to 10 healthy sows. The prevalence of MRSA colonization on days 1, 3, 7, 14 and 21 was 1% (1/100), 6.2% (3/97), 8.5% (8/94), 4.4% (4/91) and 20% (18/91) respectively, with an overall pre‐weaning prevalence of 34.5%. The prevalence on days 28, 42, 56 and 70 was 34% (31/91), 65% (57/88), 50% (44/88) and 42% (36/87) respectively, with an overall post‐weaning prevalence of 85%. Eighty‐four percent of piglets from negative sows and 100% of piglets from positive sows that survived at least until the time of weaning were colonized with MRSA at one or more times during the study. There was a significant association between sow and piglet colonization. The age of the piglet was significantly associated with the probability of colonization. No piglets or sows received antimicrobials during the study period. These results indicate that age must be considered when designing surveillance programmes and interpreting results of different studies on MRSA.
Non-contact wide-field hemodynamic imaging reveals the inverted jugular venous pulse waveform

Cardiovascular disease is the leading cause of death globally. Cardiovascular monitoring is important to prevent diseases from progressing. The jugular venous pressure waveform (JVP) is able to provide important information about cardiac health. Factors such as mechanical deformations, electric abnormalities, and irregular external forces change the fundamental shape of the JVP. However, current methods for measuring the JVP require invasive catheter insertion, or subjective qualitative visual inspection of the patient's jugular pulse. Thus, JVP are not routinely performed, and are scheduled only when there is probable cause for catheterisation. Non-invasive monitoring methods would benefit JVP monitoring. Recently, there has been a surge in focus on photoplethysmographic imaging (PPGI) systems. These systems are non-contact wide-field imaging systems able to assess blood pulse waveforms across a large area of the body. However, PPGI has not been previously explored for measuring jugular venous pulse. In this study, we demonstrate for the first time that the jugular venous pulse waveform can be observed non-invasively using a novel PPGI system, Coded Hemodynamic Imaging (CHI). While traditional monitoring methods measure the JVP at a single location, CHI's wide-field imaging capabilities made observing the pulse's spatial trajectory possible for the first time. Two distinct types of pulse waveforms were observed traveling through the neck using CHI. By analysing the interparticipant spatial patterns, signal temporal characteristics, and comparing the blood pulse waveforms to the JVP, it was concluded that these two waveforms were major arterial (carotid) and venous (jugular) blood pulse waveforms, and that the jugular pulse exhibited a strong correlation to the JVP. Thus, CHI provides a novel way to analyse cardiac health through non-contact jugular pulse waveform monitoring.
Bacterial vaginosis: an update on diagnosis and treatment

Bacterial vaginosis is the most common cause of vaginal complaints. Bacterial vaginosis is further associated with a sizeable burden of infectious complications. Diagnosis relies on standardized clinical criteria or on scoring bacterial cell morphotypes on a Gram-stained vaginal smear. A few point-of-care tests have not gained footage in clinical practice, but molecular diagnosis is now pending. Treatment remains cumbersome and clinicians are currently rather poorly armed to treat bacterial vaginosis in the long run. As an adjuvant to standard treatment with antibiotics, alternative treatments with antiseptics and disinfectants, vaginal-acidifying and -buffering agents, and probiotics hold some promise for long-term prevention.
UMTS: The Fundamentals

Preface. Digital Data Transmission. Cellular Mobile Radio Networks. Standardisation and Spectrum. UMTS System Architecture. The Protocol Stack at the Radio Interface. Data Transmission at the UMTS Radio Interface. The Physical Layer at the Radio Interface. Physical Channels and Procedures at the Radio Interface. Cellular CDMA Networks. Service Architectures and Services in UMTS. The Next Generation of Mobile Radio Systems. Answers to Questions. List of UMTS Release 4 Specifications. Acronyms. Index.
Quantitative estimation of the degree of hepatic macrovesicular steatosis in a disease‐free population: A single‐center experience in mainland China

The aim of this study was to derive a simple equation to enable the extent of hepatic macrovesicular steatosis (HMS) to be predicted quantitatively from data obtained noninvasively and hence avoid unnecessary liver biopsies. One hundred sixty‐seven potential living liver donors and 45 subjects suspected of having nonalcoholic fatty liver disease (NAFLD) underwent percutaneous liver biopsy to evaluate HMS quantitatively. Their hepatic unenhanced computed tomography (CT) attenuation, body mass index (BMI), and indices of serum lipids were reviewed. Logistic regression analysis was undertaken to screen for independent predictors of HMS. Linear regression analysis was then used to plot the relationship between the severity of histologically confirmed HMS and identified independent predictors of HMS. For potential donors with HMS of severity ≥ 5% by histological assessment, the following equation was derived: The calculated HMS for potential donors with histologically confirmed HMS of severity < 5% seemed to be unreliable (R2 = = 0.230, P < 0.3). In addition, in subjects suspected of having NAFLD, there was a close agreement between values for histologically confirmed HMS and calculated values for HMS derived from the equation (intraclass correlation coefficient = 0.88). Hepatic CT imaging in conjunction with other noninvasive clinical data may enable the extent of HMS to be accurately predicted with the equation derived from potential donors with appreciable degrees of histologically confirmed HMS. Liver Transpl 15:1605–1612, 2009. © 2009 AASLD.
Preparation and characterization of HDPE/chitosan composites for bone replacement applications

A study carried out in the Netherlands has reported that the mean rates of infections related to surgery that involves implants are in the range of 1.5% in the case of total knee implantation and 6.8% for femur head replacement, where polyethylene is widely used as cotyle. Such infections result in disease for the patient and prolongation of hospital stay, then increasing cost of care. Chitosan is the second most abundant polysaccharide found in nature after cellulose and it is the most promising bio-based polymer for tissue engineering. Chitosan is nontoxic and shows biocompatibility and antimicrobial properties. In view of preventing the disease arising from infections, this work investigates the study of HDPE composites containing chitosan in different shapes and compositions. The HDPE composites have been prepared by melt extrusion with the aim to achieve materials with good mechanical properties and antimicrobial activity for bone replacement applications. Their thermal behavior has been investigated by means of Thermogravimetric and Differential Scanning Calorimetry analyses. Dynamic-Mechanical Analysis and Scanning Electron Microscopy have provided information about mechanical behavior of the composites and the distribution of the filler within the polymer matrix, respectively.
Laparoscopic ligation of internal ring-three ports versus single-port technique: are working ports necessary?

BACKGROUND From three ports, technical refinements in laparoscopy have facilitated the ligation of the internal ring (IR) with a single port. OBJECTIVES The aims of this study were to determine whether, when, and where working ports are needed by assessing the differences in outcome between the three-port technique (TPT) and the single-port technique-subcutaneous endoscopically assisted ligation (SEAL). METHODS Short-term outcomes of 163 children operated on by either technique (51 with TPT, and 112 with SEAL) were audited. Technical difficulties, operation time, intra- and postoperative complications, and postoperative stay were studied. RESULTS IR could be ligated faster by SEAL than TPT (unilateral: 15 vs. 25 minutes; P = 0.0005; bilateral: 25 vs. 40 minutes; P = 0.001). SEAL proved cosmetically more appealing (one 5-mm vs. three 5-mm scars). Complication rates, recovery, and hospital stay were similar. Recurrences were marginally higher following SEAL (4.8 vs. 2.98%; P = 0.49). Intracorporeal suturing and knotting were the limiting steps in TPT, while wide rings (>10 mm) and thick abdominal wall were the limitations of SEAL. CONCLUSIONS Both TPT and SEAL are safe and efficacious day-care procedures. In the ligation of average-sized IR of thin patients, working ports may not be necessary, as SEAL proves cosmetically and temporally efficacious over TPT. However, patients with wide rings and thick anterior abdominal walls may need the placement of working ports for successful laparoscopic repair.
OPTIMIZATION OF THE FORMULATION PARAMETERS OF A PARAPHARMACEUTICAL 100% BIO CREAM

The extraction of the aromatic fraction (hydrolat, essential oil) fresh aerial part of Lavandula vera was accomplished by steam distillation. The average yield of essential oil is 1-2%. The anti-inflammatory cream BIO obtained has interesting dermal properties. This cream is endowed with remarkable healing properties and anti-infectious. It leads to dermatological applications and opens the way eventually fruitful research. During this work we have formulated an anti-inflammatory cream 100% BIO whose active ingredient is the essential oil of lavender with these attractive properties. Optimization of formulation parameters made it possible to have a stable cream. Physicochemical analysis, sensory (with diagram properties evaluation) and comparative study with a reference cream (conventional) was able to show the qualities of our BIO cream. Article DOI: https://dx.doi. org/10.20319/mijst.2017. 33.104112 This work is licensed under the Creative Commons Attribution-Non-commercial 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
The dermatoscopic universe of basal cell carcinoma

Following the first descriptions of the dermatoscopic pattern of basal cell carcinoma (BCC) that go back to the very early years of dermatoscopy, the list of dermatoscopic criteria associated with BCC has been several times updated and renewed. Up to date, dermatoscopy has been shown to enhance BCC detection, by facilitating its discrimination from other skin tumors and inflammatory skin diseases. Furthermore, upcoming evidence suggests that the method is also useful for the management of the tumor, since it provides valuable information about the histopathologic subtype, the presence of clinically undetectable pigmentation, the expansion of the tumor beyond clinically visible margins and the response to non-ablative treatments. In the current article, we provide a summary of the traditional and latest knowledge on the value of dermatoscopy for the diagnosis and management of BCC.
Thorny ganglion cells in marmoset retina: Morphological and neurochemical characterization with antibodies against calretinin

In primates, over 17 morphological types of retinal ganglion cell have been distinguished by their dendritic morphology and stratification, but reliable markers for specific ganglion cell populations are still rare. The calcium binding protein calretinin is known to be expressed in the inner nuclear and the ganglion cell layer of marmoset retina, however, the specific cell type(s) expressing calretinin in the ganglion cell layer are yet to be determined. Here, we identified calretinin positive retinal ganglion cells in the common marmoset Callithrix jacchus. Double labeling with the ganglion cell marker RBPMS demonstrated that the large majority (80%) of the calretinin positive cells in the ganglion cell layer are ganglion cells, and 20% are displaced amacrine cells. The calretinin positive ganglion cells made up on average 12% of the total ganglion cell population outside of the foveal region and their proportion increased with eccentricity. Prelabeling with antibodies against calretinin and subsequent intracellular injection with DiI revealed that the large majority of the injected cells (n = 74) were either narrow thorny or broad thorny ganglion cells, 14 cells were displaced amacrine cells. Narrow thorny cells were further distinguished into outer and inner stratifying cells. In addition, weakly labeled cells with a large soma were identified as parasol ganglion cells. Our results show that three types of thorny ganglion cells in marmoset retina can be identified with antibodies against calretinin. Our findings are also consistent with the idea that the proportion of wide‐field ganglion cell types increases in peripheral retina.