Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of the Effects of Ultrasound-Guided Interfascial Pulsed Radiofrequency and Ultrasound-Guided Interfascial Injection on Myofascial Pain Syndrome of the Gastrocnemius

Objective To investigate the comparative treatment effects of ultrasound-guided pulsed radiofrequency treatment (UG-PRF) in the gastrocnemius interfascial space and ultrasound-guided interfascial injection (UG-INJ) on myofascial pain syndrome. Methods Forty consecutive patients with myofascial pain syndrome of the gastrocnemius were enrolled and were allocated to one of the two groups. Twenty patients were treated by UG-PRF delivered to the gastrocnemius interfascial space (UG-PRF group) and the other 20 patients were treated by interfascial injection (UG-INJ group). The primary outcome measure was the numeric rating score (NRS) for pain on pressing the tender point in the gastrocnemius, and the secondary outcome measure was health-related quality of life as determined by the Short Form-36 questionnaire (SF-36). NRSs were obtained at the first visit, immediately after treatment, and at 2 and 4 weeks post-treatment, and physical component summary scores (PCS) and mental component summary scores (MCS) of the SF-36 questionnaire were measured at the first visit and at 4 weeks post-treatment. Results Immediately after treatments, mean NRS in the UG-PRF group was significantly higher than that in the UG-INJ group (p<0.0001). However, at 2 and 4 weeks post-treatment, the mean NRS was significantly lower in the UG-PRF group (both p<0.0001). Similarly, at 4 weeks post-treatment, mean PCS and MCS were significantly higher in the UG-PRF group (p<0.0001 and p=0.002, respectively). Conclusion Based on these results, the authors conclude that ultrasound-guided gastrocnemius interfascial PRF provides an attractive treatment for myofascial pain syndrome of the gastrocnemius.
OhioState at IJCNLP-2017 Task 4: Exploring Neural Architectures for Multilingual Customer Feedback Analysis

This paper describes our systems for IJCNLP 2017 Shared Task on Customer Feedback Analysis. We experimented with simple neural architectures that gave competitive performance on certain tasks. This includes shallow CNN and Bi-Directional LSTM architectures with Facebook’s Fasttext as a baseline model. Our best performing model was in the Top 5 systems using the Exact-Accuracy and Micro-Average-F1 metrics for the Spanish (85.28% for both) and French (70% and 73.17% respectively) task, and outperformed all the other models on comment (87.28%) and meaningless (51.85%) tags using Micro Average F1 by Tags metric for the French task.
Trends in epidemiology of colorectal cancer

The approach to the possible causative factors of colorectal cancer has changed substantially during the last 20 years. The enthusiasm aroused by the Burkitt's fiber hypothesis [1] is today partly overcome by the contradictory results from analytical studies and by the trends emerging from descriptive epidemiology. In addition, the identification of precursor lesions, such as adenomas, is shifting the interest of researchers to earlier stages of the natural history of these cancers, in the attempt to link risk factors to the development and progressions of adenomas.
Uniparental Disomy

Address correspondence to Dawn H. Siegel, M.D., 1701 Divisidaro Street, 3rd Floor, San Francisco, CA, or e-mail: siegeld@derm.ucsf. edu. Uniparental disomy (UPD) occurs when part or all of both chromosomes of an individual pair are inherited from only one parent, rather than one chromosome of a pair coming from the mother and the other chromosome in the pair coming from the father, as is the normal situation. Uniparental disomy can occur with either the father’s (paternal) or mother’s (maternal) chromosomes. There are two main types of UPD: uniparental isodisomy or isodisomy occurs if the same chromosome is present in duplicate. This occurs when failure of the chromatids to separate occurs at the second meiotic division. Uniparental heterodisomy or heterodisomy occurs if two different chromosome homologs from one parent are present. This occurs when the failure of normal disjunction occurs at the first meiotic (reduction) division (Fig. 1A,B). The term UPD was first coined by Engel (1) in 1980, who postulated that a partial diploid sequence, or occasionally an entire chromosome pair could come exclusively from one parent. Since the original description, there have been over 100 case reports of uniparental disomy (2,3).
[Assessment of diet in patients with chronic kidney diseases without dialysis and relationship with the nutritional status].

BACKGROUND Diet is one of the pillars of the treatment for patients with chronic kidney disease without dialysis (NDD-CKD). Despite this, very few studies have evaluated the diet in Spanish population. OBJECTIVE To evaluate the diet of a group of patients with advanced CKD, comparing it with the recommendations, and its relation with nutritional status. MATERIAL AND METHODS A cross-sectional study of 74 patients (39 men), with a mean age of 70.9 ± 13.6 years and creatinine clearance of 15.3 ± 2.1 mL/min. Biochemical, anthropometric and intake variables (3-day dietary record) were collected, comparing them with the recommendations for patients with CKD and, if they did not exist, with nutritional recommendations and objectives for the Spanish population. The nutritional status was assessed by modified criteria of protein-energy wasting (PEW). RESULTS The mean energy intake was 23.2 ± 6.5 kcal/kg body weight/day, and the protein intake was 0.93 ± 0.2 g/kg body weight/day. Men had a higher intake of alcohol and vitamin D whereas women presented a higher intake of trans fatty acids and vitamin B1. In addition, 91.4% of patients had high intake of phosphorus and 73% of potassium. Only 2.7% showed an adequate intake of vitamin D and 21.6% of folates; 18.9% of patients presented PEW. A positive correlation was found between albumin, body mass index (BMI) and creatinine clearance. CONCLUSION Most patients with non-dialysis CKD do not meet dietary recommendations or nutritional goals, regardless of gender and PEW status, considering renal function as a limiting factor.
Developmental events and shoot apical meristem gene expression patterns during shoot development in Arabidopsis thaliana.

Critical developmental and gene expression profiles were charted during the formation of shoots from root explants in Arabidopsis tissue culture. Shoot organogenesis is a two-step process involving pre-incubation on an auxin-rich callus induction medium (CIM) during which time root explants acquire competence to form shoots during subsequent incubation on a cytokinin-rich shoot induction medium (SIM). At a histological level, the organization of shoot apical meristems (SAMs) appears to occur during incubation on SIM about the time of shoot commitment, i.e. the transition from hormone-dependent to hormone-independent shoot development. Genes involved in SAM formation, such as SHOOTMERISTEMLESS (STM) and CLAVATA1 (CLV1), were upregulated at about the time of shoot commitment, while WUSCHEL (WUS) was upregulated somewhat earlier. Genes required for STM expression, such as CUP-SHAPED COTYLEDON 1 and 2 (CUC1 and 2) were upregulated prior to shoot commitment. Gene expression patterns were determined for two GFP enhancer trap lines with tissue-specific expression in the SAM, including one line reporting on CUC1 expression. CUC1 was generally expressed in callus tissue during early incubation on SIM, but later CUC1 was expressed more locally in presumptive sites of shoot formation. In contrast, the expression pattern of the enhancer trap lines during zygotic embryogenesis was more localized to the presumptive SAM even in early stages of embryogenesis.
The role of directionally selective neurons in the perception of global motion

Dynamic random dot targets consisting of many localized motion vectors have been used to study the pooling of local motion signals into a global motion percept (Williams and Sekuler, 1984). In such displays, the dots are displaced with a constant step size and the direction of motion for each dot is chosen at random from a specified distribution. When the distribution extends over 360 deg, the display consists only of local random motion of individual dots and no coherent motion is reported. However, when the distribution is less than 360 deg (biased), the stimulus appears to flow in a single direction. We examined the effects of reducing the number of directionally selective (DS) cortical neurons on this integration process. Normal cats and cats with severely reduced proportions of DS neurons were trained on 2 direction discrimination tasks. The discrimination of opposite directions was examined while varying either the range of directions of local motion, or the proportion of dots moving with biased distribution. When all dots in the display were directionally biased, cats with reduced numbers of DS neurons performed the task as well as normal cats and humans (threshold range: 280-320 deg). However, when the proportion of biased dots decreased, these animals had severe deficits. Thus, in the absence of noise, even a very small number of DS neurons can perform spatial pooling of local directional signals, and support normal discrimination of opposite directions. However, a full complement of directional detectors appears necessary when the motion signal is masked by noise. The discrimination of small differences in direction revealed far more severe deficits, even when all the dots in the display were directionally biased (no noise). (ABSTRACT TRUNCATED AT 250 WORDS)
Ergonomics diagnosis components in rehabilitation: statistical evaluation of an assessment instrument

The current paper examines an assessment instrument used for combined medical and occupational rehabilitation (MOR) in a group of German hospitals. Patients with a history of musculo-skeletal disease make up a significant proportion of those undergoing rehabilitation. Scale and factor structures, discriminant factors and clustering procedures used in the Bavaria rehabilitation patient assessment method (BRPAM) are investigated in a cross-sectional study involving a sample of 800 patients. Although the results reveal good correlation between differences in the job demand/patient capability profiles and the typical stresses to which the relevant occupation is exposed, analyses also indicate that several factors and items are unstable. According to subjective assessment by the patients, the therapeutic objectives are fully attained in some 80% of cases. Discrepancies between job demands and patient capability revealed by the BRPAM yield pointers to choice of therapy and its chances of success, but these need to be examined in greater detail in long-term studies.
Effective classes and Lagrangian tori in symplectic four-manifolds

An effective class in a closed symplectic four-manifold (X,ω) is a twodimensional homology class which is realized by a J-holomorphic cycle for every tamed almost complex structure J . We prove that effective classes are orthogonal to Lagrangian tori in H2(X;Z).
The Ability To Replicate in Macrophages Is Conserved between Yersinia pestis and Yersinia pseudotuberculosis

ABSTRACT Yersinia pestis, the agent of plague, has arisen from a less virulent pathogen, Yersinia pseudotuberculosis, by a rapid evolutionary process. Although Y. pestis displays a large number of virulence phenotypes, it is not yet clear which of these phenotypes descended from Y. pseudotuberculosis and which were acquired independently. Y. pestis is known to replicate in macrophages, but there is no consensus in the literature on whether Y. pseudotuberculosis shares this property. We investigated whether the ability to replicate in macrophages is common to Y. pestis and Y. pseudotuberculosis or is a unique phenotype of Y. pestis. We also examined whether a chromosomal type III secretion system (TTSS) found in Y. pestis is present in Y. pseudotuberculosis and whether this system is important for replication of Yersinia in macrophages. A number of Y. pestis and Y. pseudotuberculosis strains of different biovars and serogroups, respectively, were tested for the ability to replicate in primary murine macrophages. Two Y. pestis strains (EV766 and KIM10+) and three Y. pseudotuberculosis strains (IP2790c, IP2515c, and IP2666c) were able to replicate in macrophages with similar efficiencies. Only one of six strains tested, the Y. pseudotuberculosis YPIII(p−) strain, was defective for intracellular replication. Thus, the ability to replicate in macrophages is conserved in Y. pestis and Y. pseudotuberculosis. Our results also indicate that a homologous TTSS is present on the chromosomes of Y. pestis and Y. pseudotuberculosis and that this secretion system is not required for replication of these bacteria in macrophages.
Effects of Mechanical Factors on the Fracture Healing Process

An interdisciplinary study based on animal experiments, cell culture studies, and finite element models is presented. In a sheep model, the influence of the osteotomy gap size and interfragmentary motion on the healing success was investigated. Increasing gap sizes delayed the healing process. Increasing movement stimulated callus formation but not tissue quality. Typical distributions of intramembranous bone, endochondral ossification, and connective tissue in the fracture gap are quantified. The comparison of the mechanical data determined by a finite element model with the histologic images allowed the attribution of certain mechanical conditions to the type of tissue differentiation. Intramembranous bone formation was found for strains smaller than approximately 5% and small hydrostatic pressure (<0.15 MPa). Strains less than 15% and hydrostatic pressure more than 0.15 MPa stimulated endochondral ossification. Larger strains led to connective tissue. Cell culture studies on the influence of strain on osteoblasts supported these findings. Proliferation and transforming growth factor beta production was increased for strains up to 5% but decreased for larger strains. Osteoblasts under larger strains (>4%) turned away from the principal strain axis and avoided larger deformations. It is hypothesized that gap size and the amount of strain and hydrostatic pressure along the calcified surface in the fracture gap are the fundamental mechanical factors involved in bone healing.
Quasi-Discrete Dynamics of a Neural Net: The Lighthouse Model

This paper studies the features of a net of pulse-coupled model neurons, taking into account the dynamics of dendrites and axons. The axonal pulses are modelled by f (2) stability of phase-locked state with respect to perturbations, such as phase jumps and random fluctuations, the correlation functions of the phases are calculated; (3) phase shifts due to spontaneous opening of vesicles or due to failure of opening; (4) effect of different sensory inputs on axonal pulse frequencies of coupled neurons.
Development of incremental strategies for wireless sensor network

Adaptive filter plays an important role in the field of digital signal processing and wireless communication. It incorporates LMS algorithm in real time environment because of its low computational complexity and simplicity. The LMS algorithm encompasses RLS (recursive least square), GN (Gaussian Newton), LMF (least mean fourth) and XE-NLMF algorithms, which provides faster convergence rate and low steady state error when compared to LMS. The adaptive distributed strategy is based on the incremental mode of co-operation between different nodes, which are distributed in the geographical area. These nodes perform local computation and share the result with the predefined nodes. The resulting algorithm is distributed, co-operative and able to respond to the real time change in environment. By using incremental method, algorithms such as RLS,GN, DCT-LMS and DFT-LMS produces faster convergence and better steady state performance than that of the LMS when simulated in the presence of Gaussian noise. Higher Order error algorithm like LMF, XE-NLMF and variable XE-NLMF algorithm produce better convergence and steady state performance under Gaussian and non-Gaussian noise. A spatial-temporal energy conservation argument is used to evaluate the steady state performance of the entire network. A topology named as CLMS (convex LMS) was presented which combined the effect of both fast and accurate filtering at the same time. Initially CLMS have parallel independent connection, the proposed topology consists of series convex connection of adaptive filters, which achieves similar result with reduced time of operation. Computer simulations corroborate the results.
A heads-up no-limit Texas Hold'em poker player: discretized betting models and automatically generated equilibrium-finding programs

We present Tartanian, a game theory-based player for heads-up no-limit Texas Hold'em poker. Tartanian is built from three components. First, to deal with the virtually infinite strategy space of no-limit poker, we develop a discretized betting model designed to capture the most important strategic choices in the game. Second, we employ potential-aware automated abstraction algorithms for identifying strategically similar situations in order to decrease the size of the game tree. Third, we develop a new technique for automatically generating the source code of an equilibrium-finding algorithm from an XML-based description of a game. This automatically generated program is more efficient than what would be possible with a general-purpose equilibrium-finding program. Finally, we present results from the AAAI-07 Computer Poker Competition, in which Tartanian placed second out of ten entries.
Sphenoidal Electrodes Significantly Change the Results of Source Localization of Interictal Spikes for a Large Percentage of Patients With Temporal Lobe Epilepsy

Summary Although scalp EEG is a very useful tool for presurgical evaluation in epilepsy, the 10-20 system of electrodes in many cases fails to accurately localize the source of the epileptic seizures. One suggested solution to this problem is to use additional electrodes. Sphenoidal electrodes especially have been suggested to be helpful in identifying the irritative and seizure onset zones in patients with temporal lobe epilepsy. However, the value of these electrodes has been debated, and in many epilepsy centers they are not used. In this study, we investigate the impact of sphenoidal electrodes by comparing the results of EEG source localization with and without sphenoidal recordings. We retrospectively selected patients with temporal lobe epilepsy based on their clinical semiology and electrophysiologic data. For each patient, a prototype spike was used as a template for an automatic pattern search to find similar activities. The identified spikes were then averaged and analyzed by fitting a dipole to the data. The recordings from sphenoidal electrodes were then excluded and the analysis was repeated. It was found that in more than half of the patients inclusion of sphenoidal electrodes resulted in a shift of more than 2 cm in the location of the fitted dipole, and in some cases moved the dipole from the frontal lobe or the insula to the temporal lobe. Our results suggest that sphenoidal electrodes are helpful in the analysis of the EEG recordings of patients suspected of having temporal lobe epilepsy.
Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry

The role of BubR1 has been established mainly in mitosis as an essential mitotic checkpoint protein although it is expressed throughout the cell cycle. To explore a possible role of BubR1 in regulating the G2 phase of cell cycle, we have employed siRNA–mediated hBubR1 knockdown in HeLa cells. Here, we demonstrate that reducing BubR1 levels during the G2 phase causes accelerated mitotic entry. As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted to centrosomes appearing at early G2 phase in BubR1-depleted cells despite its low levels. This is in contrast to control cells where cyclin B1 appears at the centrosomes in early prophase based on cell cycle-specific localization of CENP-F. Furthermore, cyclin B/Cdk1 kinase activity in early G2 is aberrantly high in BubR1-depleted cells. Together, our results indicate that hBubR1 depletion triggers premature centrosomal localization of cyclin B1 probably leading to premature mitotic entry. This study is the first to suggest a role of hBubR1 in controlling centrosome targeting of cyclin B1 and timing of mitotic entry.
THE EFFECT OF PEER EDUCATION ON UNIVERSITY STUDENTS ’ KNOWLEDGE OF BREAST SELF-EXAMINATION AND HEALTH BELIEFS

Bulgular: Öğrencilerin KKMM bilgilerinin eğitimden sonra anlamlı olarak arttığı belirlendi. Akranı tarafından grup olarak eğitilen öğrencilerin KKMM bilgilerinde, bireysel olarak eğitilenlere göre daha fazla artış saptandı. Gerek bireysel gerekse grup olarak eğitilen öğrencilerin eğitimden sonra güven algılarında anlamlı yükselme olduğu belirlendi. Akran eğitiminde kullanılan yöntemlerin öğrencilerin eğitimden sonraki sağlık inancı alt boyutlarını farklı biçimde etkilemediği saptandı.
Quantitative characterization of the transcriptional regulatory network in the yeast cell cycle

MOTIVATION Genome-wide gene expression programs have been monitored and analyzed in the yeast Saccharomyces cerevisiae, but how cells regulate global gene expression programs in response to environmental changes is still far from being understood. We present a systematic approach to quantitatively characterize the transcriptional regulatory network of the yeast cell cycle. For the interpretative purpose, 20 target genes were selected because their expression patterns fluctuated in a periodic manner concurrent with the cell cycle and peaked at different phases. In addition to the most significant five possible regulators of each specific target gene, the expression pattern of each target gene affected by synergy of the regulators during the cell cycle was characterized. Our first step includes modeling the dynamics of gene expression and extracting the transcription rate from a time-course microarray data. The second step embraces finding the regulators that possess a high correlation with the transcription rate of the target gene, and quantifying the regulatory abilities of the identified regulators. RESULTS Our network discerns not only the role of the activator or repressor for each specific regulator, but also the regulatory ability of the regulator to the transcription rate of the target gene. The highly coordinated regulatory network has identified a group of significant regulators responsible for the gene expression program through the cell cycle progress. This approach may be useful for computing the regulatory ability of the transcriptional regulatory networks in more diverse conditions and in more complex eukaryotes. SUPPLEMENTARY INFORMATION Matlab code and test data are available at http://www.ee. nthu.edu. tw/~bschen/quantitative/regulatory_network. htm