Miracle-dz/UniFAR-FTUs huggingface dataset:
miR‑3120/Hsc70 participates in forced swim stress‑induced mechanical hyperalgesia in rats in an inflammatory state

The heat shock cognate 71 kDa protein (Hsc70) is a stress-inducible ATPase that can protect cells against harmful stimuli. Transient receptor potential vanilloid 1 (TRPV1) is a well-documented nociceptor. Notably, Hsc70 can inhibit TRPV1 expression and function, suggesting that Hsc70 may have pain regulation potential. However, the role of Hsc70 in stress-induced hyperalgesia remains unclear. In the present study, the participation of Hsc70 and its regulator microRNA (miR)-3120 were investigated in forced swim (FS) stress-induced mechanical hyperalgesia in rats in an inflammatory state. Complete Freund's adjuvant (CFA) hind paw injection was performed to induce inflammatory pain in rats (CFA rats). Furthermore, in FS + CFA rats, FS stress was performed for 3 days before CFA injection. The levels of Hsc70, miR-3120 and their downstream molecule TRPV1 were measured in the dorsal root ganglion (DRG) with western blotting, immunofluorescence, reverse transcription-quantitative polymerase chain reaction and fluorescence in situ hybridization. The results revealed that FS stress significantly exacerbated CFA-induced mechanical pain. Furthermore, CFA upregulated Hsc70 and TRPV1 expression, which was partially inhibited or further enhanced by FS stress, respectively. In FS + CFA rats, intrathecal injection of a lentiviral vector overexpressing Hsc70 (LV-Hsc70) could decrease TRPV1 expression and improve the mechanical pain. Additionally, the expression level of miR-3120, a regulator of Hsc70, was markedly upregulated on day 3 following FS stress. Finally, miR-3120 was identified to be colocalized with Hsc70 and expressed in all sizes of DRG neurons. In CFA rats, DRG injection of miR-3120 agomir to induce overexpression of miR-3120 resulted in similar TRPV1 expression and behavioral changes as those caused by FS stress, which were abolished in the presence of LV-Hsc70. These findings suggested that miR-3120/Hsc70 may participate in FS stress-induced mechanical hyperalgesia in rats in an inflammatory state, possibly via disinhibiting TRPV1 expression in the DRG neurons.
Unlocking the Potential for Creative Thinking Ability and Self-Efficacy: Implementation of Numbered Head Together and Algebra Blocks in Middle School Students

This study examines how algebra block support and the Numbered Head Together (NHT) learning paradigm affect secondary school students' mathematical creativity and self-efficacy. The literature review highlights the necessity of creative teaching strategies in mathematics education. In this study, a non-equivalent control group was utilized in a controlled experimental design, with one group implementing the NHT model with algebra block support and another group employing traditional teaching techniques. Pretest, posttest, and self-efficacy instruments were used to gather data. The study's results indicated a significant increase in students' mathematical creativity capacity when utilizing algebra blocks to support the NHT model. In addition, there was a noticeable increase in the pupils' self-efficacy. An examination of the data using statistical methods revealed notable distinctions between the experimental and control groups. The primary finding indicates that the NHT learning paradigm, in conjunction with algebra blocks, helps enhance secondary school students' mathematical creativity and self-efficacy capacity. The study's findings offer insightful information about initiatives to enhance methods for teaching mathematics.
CLIMATE VARIABILITY IN DRY REGIONS OF INDIA: A CASE STUDY OF RAJASTHAN

The global community is in panic with fear of changing climate. Though it is very difficult to experience phenomenon of climate change but we can say that the climate is showing huge variability. To understand the impact of human on climate and vice-versa the knowledge of climate variability is necessary and moreover it helps in prediction of future trends of climate. In this paper spatio-temporal analysis of climate variation has been done by using interpolation technique. About 61 per cent of total area of India has dry climate and its typical example is western part of Rajasthan. In the Western Rajasthan during last 30 years the temperature has shown a great variability with an average rise of about 0.5 oC for the month of June and 1oC for the month of January. During the same period the average annual rainfall has shown a decrease of 50 mm. With an overall rise in temperature over the region and changing precipitation trends the humidity provinces as defined by Thornthwaite, have shifted eastward. The climate variability studies can help to identify vulnerability of a region towards climate change which further helps in formulation of mitigation and adaptation strategies.
Adequacy of governance in the link between foreign direct investment and structural transformation

Abstract The inflow of foreign direct investment has increased in developing nations. The study used panel data from sub-Saharan Africa and East Asia and the Pacific countries to observe the adequacy of governance in linking FDI and structural transformation. Pooled Mean Group estimation technique is utilized for analysis purposes using 31-year-old data. The econometric results suggest that FDI inflows boost structural transformation, while debt and inflation dis-improve structural transformation. Across countries, in the short run, FDI with governance had a negative effect for South Korea. Accordingly, the governments of these regions that attempt to succeed in structural transformation should focus on active utilization of FDI and minimize massive inflow of foreign public debts.
Response to Cadmium in Silene vulgaris Ecotypes Is Distinctly Affected by Priming-Induced Changes in Oxidation Status of Macromolecules

This study investigated the impact of several priming agents on metal-tolerant and sensitive Silene vulgaris ecotypes exposed to environmentally relevant cadmium dose. We analyzed how priming-induced changes in the level of lipid, protein, and DNA oxidation contribute to calamine (Cal) and non-calamine (N-Cal) ecotype response to Cd toxicity, and whether the oxidative modifications interrelate with Cd tolerance. In non-primed ecotypes, the levels of DNA and protein oxidation were similar whereas Cal Cd tolerance was manifested in reduced lipid peroxidation. In both ecotypes protective action of salicylic acid (SA) and nitric oxide (NO) priming was observed. SA stimulated growth and reduced lipid and DNA oxidation at most, while NO protected DNA from fragmentation. Priming with hydrogen peroxide reduced biomass and induced DNA oxidation. In N-Cal, priming diminished Cd accumulation and oxidative activity, whereas in Cal, it merely affected Cd uptake and induced protein carbonylation. The study showed that priming did not stimulate extra stress resistance in the tolerant ecotype but induced metabolic remodeling. In turn, the lack of adaptive tolerance made the sensitive ecotype more responsive to the benefits of the primed state. These findings could facilitate priming exploitation with a view of enhancing metallophyte and non-metallophyte suitability for phytoremediation and land revegetation.
Genome assembly and annotation of the Brown-Spotted Pit viper Protobothrops mucrosquamatus

The Brown-Spotted Pit viper (Protobothrops mucrosquamatus), also known as the Chinese habu, is a widespread and highly venomous snake distributed from Northeastern India to Eastern China. Genomics research can contribute to our understanding of venom components and natural selection in vipers. Here, we collected, sequenced and assembled the genome of a male P. mucrosquamatus individual from China. We generated a highly continuous reference genome, with a length of 1.53 Gb and 41.18% of repeat elements content. Using this genome, we identified 24,799 genes, 97.97% of which could be annotated. We verified the validity of our genome assembly and annotation process by generating a phylogenetic tree based on the nuclear genome single-copy genes of six other reptile species. The results of our research will contribute to future studies on Protobothrops biology and the genetic basis of snake venom.
Comparative assessment of actuator-Line modeling of FOWT rotor aerodynamics to wind tunnel experiments

The paper presents aerodynamic analyses of the scaled DTU 10MW laboratory model with surge and pitch platform motion in controlled environment applying an Actuator Line Method (ALM) to reproduce the experiments conducted in the large-scale Wind Tunnel of the Politecnico di Milano during UNAFLOW and OC6 Phase III test campaigns. The Effective Velocity Method (EVM) is implemented in the in-house ALM solver to sample the velocity at actuator points and determine the angle of attack. Fixed-bottom wind turbine URANS simulations reveal that thrust and torque deviations are within 3% and 5% respectively to experimental counterparts. Platform surge and pitch are simulated with ALM adopting a combination of motion frequencies and amplitudes finding a good agreement with experimental counterparts both in terms of loads and wake quantities. This paper also shows the capability of in-house ALM to model control strategies, imposing sinusoidal variation of blade collective pitch, which might generate dynamic inflow conditions. An in-depth cross comparison is conducted on FOWT wake quantities to investigate the flow behaviour and wake recovery induced by floating motion.
Settlement of Bioreactor Landfills During Filling Operation

The knowledge of the rate and amount of settlement is important for effective design and operation of bioreactor landfills. Accurate knowledge of settlement would allow estimation of air space, planning of construction sequence, design of both intermediate and final covers as well as planning for expansions. It is also essential for the design of piping systems used for the delivery of re-circulated leachate and landfill gas recovery. Though the majority of settlement takes after landfill closure over a number of years, considerable amount occurs during the filling and construction stages, which usually goes unnoticed. In the Calgary biocell, which is a bioreactor landfill, real-time waste settlement data was collected during the filling of the cell. The field data collected during the cell construction stage is presented in this manuscript. The settlement trend follows the waste filling operation. The data was analyzed and the average unit weight of the waste matrix and the compression index were calculated. These two parameters are can be used in models to predict early stage waste settlement. The compression index was calculated as 0.21 while the unit weight of waste was 5.6 kPa.
Control of the Agulhas leakage by the Antarctic Circumpolar Current: The role of the Weddell Sea sea-surface salinity

We used a global ocean model with coarse horizontal, but high vertical resolution, isopycnal mixing, meso-scale eddy parameterizations and Last Glacial Maximum (LGM) surface boundary conditions based on the GLAMAP 2000 project (Sarnthein et al. 2003). The surface wind forcing was simulated by an atmospheric general circulation model and kept constant in all glacial experiments. However, we used different values of the LGM Weddell Sea sea-surface salinity (SSS) anomaly (see Paul and Schäfer-Neth 2003 for details of the experimental set up).
Measuring and modelling the water use of fruit tree orchards in the Western Cape province of South Africa

INTRODUCTION There is increasing competition among the various sectors of the South African economy for limited water resources, and irrigated agriculture is estimated to use approximately 60% of available surface water (NWRS2, 2012). With a 90% dependence on irrigation, it is important that the fruit tree industry improves irrigation scheduling and efficiencies in both the summer and winter rainfall areas of South Africa, where water stress is increasing. It is a goal of the modern horticultural industry to use less water, without compromising fruit quality, size, yield and profits. Technological advances in sap flow and energy balance monitoring instrumentation allow for the quantification of exact amounts of water used for transpiration (individual tree water use) and total evaporation (orchard water use). This knowledge can aid on-farm water management planning, irrigation scheduling, and the development of decision support tools such as models for predicting water use by fruit tree orchards. In a project solicited and funded by the Water Research Commission (WRC, 2008), the CSIR is collaborating with the University of Pretoria to study the water-use of fruit tree orchards. The primary objectives are:
Mineralogical and Chemical Characteristics of the Serpentinites from Boula-Nausahi Igneous Complex, Orissa

The ultramafic rocks of Boula-Nausahi igneous complex have undergone extensive alteration resulting in the development of serpentinites. Petrographic and mineralogical observations have led to the recognition of two stages of mineral formation. The first stage (retrograde metamorphism) is characterised by complete transformntion of magmatic olivine to lizardite and the second stage (prograde metamorphism) in the formation of antigorite and alteration of accessory chrome spinels. Mineral assemblages indicate serpentinization to be a low temperature oxidation phenomenon. Formation of magnetite, ferritchromit and sulphide minerals is controHed by oxygen and sulphur fugacities prevalent during the process of serpentinization. Mineralogy, chemistry and geological setting of the serpentinites indicate an isochemical nature of the serpentinization process.
An earth system approach to understanding the end-Ordovician (Hirnantian) mass extinction

The Hirnantian mass extinction is recognized as the first of the "big three" extinctions and, along with the end-Permian and end-Cretaceous events, is the result of an acceleration in biotic extinctions concomitant with a rise in originations. The Hirnantian mass extinction is characterized by high taxonomic impact and within-­community extinctions. The Hirnantian mass extinction is also unusual in that (1) it is associated with glaciation, but there is little evidence elsewhere in the younger Phanerozoic that glaciations have been a cause of mass extinction, and (2) there is limited understanding of how glaciation could directly cause mass extinction, particularly in the marine realm. In this review, we argue that coordinated extinctions occurred at the onset and termination of glaciation and were due to climatically induced changes in relative sea level, ocean redox stratification, and sea-surface temperature gradients. These earth system changes resulted in a reduction in prospective niche space, both in the water column and on the seafloor, which in turn led to increased competition and selection pressures, resulting in extinctions where the carrying capacities of particular ecological niches were exceeded. The long-term ventilation of the oceans broke the link between glaciation and mass extinction.
Method Validation and Measurement Uncertainty (MU) Evaluation on Enrofloxacin and Ciprofloxacin in the Aquatic Products

This study aimed to investigate a detection method of enrofloxacin and ciprofloxacin to be avail for strictly supervising the quality and safety of aquatic products. The results displayed that the optimal extraction conditions for enrofloxacin and ciprofloxacin were the following five aspects: 15 g dosages of Na2SO4 to dehydrate, 8‰ of acetonitrile and 50% hydrochloric acid to deproteinization, 2 mL dosages of n-hexane to degrease, 10 min of ultrasonic time, and 20 min of extraction (stand) time. Meanwhile, it was also obtained for the optimal detection performance indexes of the recovery, precision, and accuracy from the tests of shrimp, grass carp, and tilapia. In particular, the expanded uncertainties were 2.8601 and 0.8613, and the factors of both the calibration curves (Urel(C)) and the analysis of the experiment (Urel(E)) were the two MU main contributors for enrofloxacin and ciprofloxacin together with the results above 40%. Consequently, the developed novel method was suited for the determination of the enrofloxacin and ciprofloxacin residues in aquatic products and would contribute to reinforce in supervision and inspection of the quality and safety of aquatic products.
Mediterranean Conference on Information Systems ( MCIS ) 10-2008 GLOBAL INDEX CONSTRUCTION FOR DATA INTEGRATION IN LARGE SCALE SYSTEM

Several scientific projects focused on the creation of Peer-to-Peer data management system. The main objective of these systems is to allow data sharing and integration among a large set of distributed, heterogeneous data sources. The emergence of large scale systems provides solutions and brings to surface new challenging unsolved problems, among which, we address the data integration problem. In order to address this problem, we propose a new data integration approach that allows the semantic integration of heterogeneous and distributed data sources in a Peer-to-Peer environment with high distribution and evolution support. In this paper, we provide an introduction to the approaches; problems and research issues encountered when dealing with data integration.We present our approach and describe the several methods for constructing a global index that is the core of our approach by using semantic similarities. We end our work by an application example.
Impact of COVID-19 Pandemic on Healthcare-Associated Infections: A Systematic Review and Meta-Analysis

This study investigated how the Coronavirus Disease 2019 (COVID-19) pandemic has affected the rate of healthcare-associated infections (HAIs). PubMed, Scopus and Google Scholar were searched to identify potentially eligible studies published from December 2019 to September 2022. A random effect model was used to determine the changes in the rate of HAIs during the pandemic. Thirty-seven studies, mostly from the United States (n = 13), were included. Fifteen studies described how the pandemic affected the rate of CLABSIs and CAUTIs, and eight of them showed a significant increase in CLABSIs. The risk of CLABSIs and CDIs was 27% (pooled odds ratio [OR]: 0.73; confidence interval [CI]: 0.61–0.89; p < 0.001) and 20% (pooled OR: 1.20; CI: 1.10–1.31; p < 0.001) higher during the pandemic compared to before the COVID-19 pandemic period, respectively. However, the overall risk of HAIs was unaffected by the pandemic (pooled OR: 1.00; 95 CI: 0.80–1.24; p = 0.990). Furthermore, there were no significant changes in the risk of CAUTIs (pooled OR: 1.01; 95 CI: 0.88–1.16; p = 0.890), and SSIs (pooled OR: 1.27; CI: 0.91–1.76; p = 0.16) between the two periods. The COVID-19 pandemic had no effect on the overall risk of HAIs among hospitalized patients, but an increased risk of CLABSIs and CDI were observed during the pandemic. Therefore, more stringent infection control and prevention measures and prudent interventions to promote the rational use of antibiotics are warranted across all healthcare facilities to reduce the burden of HAIs.
Emergency communications after earthquake reveal social network backbone of important ties

Abstract Social networks provide a basis for collective resilience to disasters. Combining the quasi-experimental context of a major earthquake in Ya’an, China, with anonymized mobile telecommunications records regarding 91,839 Ya’an residents, we use initial bursts of postdisaster communications (e.g. choice of alter, order of calls, and latency) to reveal the “important ties” that form the social network backbone. We find that only 26.8% of important ties activated during the earthquake were the strongest ties during normal times. Many important ties were hitherto latent and weak, only to become persistent and strong after the earthquake. We show that which ties activated during a sudden disaster are best predicted by the interaction of embeddedness and tie strength. Moreover, a backbone of important ties alone (without the inclusion of weak ties ordinarily seen as important to bridge communities) is sufficient to generate a hierarchical structure of social networks that connect a disaster zone's disparate communities.
A Summary of First Year Activities of the United Arab Emirates Unified Aerosol Experiment: UAE(2)

Abstract : In August and September of 2004, scientists from two dozen international research organizations converged in the Arabian Gulf region to participate in the United Arab Emirates Unified Aerosol Experiment (UAE). The four primary goals of the mission were to (a) provide the first ground truth of a variety of environmental satellite and model products in this extremely complicated region of the world, (b) perform the first assessment of the nature of aerosol particles in the Arabian Gulf, (c) determine the role of aerosol particles on the radiative balance of desert regions, and (d) understand how perturbations in the earth's radiative balance can influence atmospheric flow patterns from local to regional scales. This progress report is compiled for mission sponsors and other interested parties. Given, is an overview of the program and individual reports from key investigators. Specific areas of intense interest include understanding the atmospheric flow patterns of Southwest Asia using a suite of mesoscale and global models. The calibration/validation of satellite sensors such as the Multi-angle Imaging Spectro-radiometer (MISR), the MODerate resolution Imaging Spectro-radiometer (MODIS), the Advanced Along Tract Scanning Radiometer (AATSR), and the Advanced Very High Resolution Radiometer (AVHRR) was also very successful. Lastly, this mission has provided the very first complete study of the chemical, physical, and optical properties of pollution and dust particles in the Arabian Gulf.
Diagnostic accuracy of a remote eye exam in measuring refractive errors and detecting cataract, glaucoma, and diabetic retinopathy

Porpuse: Approximately 2.2 billion people worldwide have some type of visual impairment and among these, many could have been avoided or solved if adequate care had been provided in a timely manner. In these cases, telemedicine can assist in solving the problems of many ophthalmological conditions by providing support, performing screening, telediagnosis or supervision of distant appointments. The use of telemedicine for eye health is well established for some eye diseases, such as diabetic retinopathy, macular diseases and strabismus, however, there is a lack of information on diagnostic accuracy for other ophthalmological pathologies prevalent in the world population, such as refractive errors. To evaluate the reliability of the diagnosis made through teleophthalmology, using the ophthalmologist's face-to-face diagnosis as the gold standard. Methods: A diagnostic accuracy study was carried out, with 216 patients assessed by the TeleOftalmo project who underwent eye examinations both on-site and through telemedicine. The patients underwent refraction tests, intraocular pressure measurement, photodocumentation in the slit-lamp and subjective refraction using the visual acuity screen and the digital refractor. Results: The conditions evaluated were refractive errors, cataracts, diabetic retinopathy and suspected glaucoma. Kappa values, sensitivity, specificity, positive predictive value and negative predictive value were calculated. Approximately, 61.6% of the sample were women, with mean age of 47 years old. Kappa values show strong reliability regarding the diagnosis of cataracts (k = 0.86) and diabetic retinopathy (k = 0.79). Regarding refractive errors and suspected glaucoma, the kappa values were considered moderate (k = 0.598 and 0.478, respectively). Conclusion: The use of telemedicine has shown favorable results regarding the diagnosis of refractive errors, cataracts and diabetic retinopathy, as well as moderate reliability for suspected glaucoma.