Miracle-dz/UniFAR-FTUs huggingface dataset:
Knemometric assessment of systemic activity of once daily intranasal dry‐powder budesonide in children

Systemic activity of the intranasal glucocorticosteroid budesonide administered once daily from a dry‐powder inhaler (Turbuhaler®) was assessed by knemometry. Lower leg length was measured weekly in 38 children aged 7–15 (mean 11.3) years with allergic or perennial rhinitis. The design was a randomized, double‐blind, parallel‐group study. After 4 weeks’ run‐in, the children were allocated to 4 weeks’ treatment with either budesonide 200 or 400 μg or placebo. Fourteen children in the budesonide 200‐μg group, 13 in the 400‐μg group, and 10 in the placebo group completed the study. In the placebo and budesonide 200‐μg groups, growth velocities during run‐in (0.36 and 0.28 mm/week, respectively) and treatment periods (0.34 and 0.27 mm/week, respectively) were almost identical. In the budesonide 400‐μg group (run‐in: 0.40 mm/week), a nonsignificant reduction in mean growth velocity of 0.18 mm/week was seen (P= 0.11). There were no statistically significant differences among the run‐in mean lower leg growth velocities (F= 1.12; P= 0.34), among growth velocities during treatment (F= 1.10; P= 0.34), or among the run‐in and treatment growth velocities in the three groups (F= 1.19; P= 0.32). These results provide good evidence that systemic activity is low in children with allergic or perennial rhinitis treated with once daily budesonide in doses of 200‐ and 400‐μg administered intranasally from a dry‐powder inhaler.
High selectivity miniaturized broadband filter

Design of a compact broadband filter using tightly coupled line sections in defected (A slot is cut in the ground) microstrip medium operating from 3.1–6.8 GHz has been reported in this article. Filter has been designed and analyzed using an equivalent circuit model based on even and odd mode parameters of coupled line sections. The proposed filter has attenuation poles on either side of the pass band resulting in improved selectivity. This filter features spurious‐free response up to third harmonic frequency. Experimental results of the filter have been validated against the analytical and full wave simulations. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:184–187, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25676
Aportaciones en el estudio de la asimetría funcional

Several theoretical have analysed and studied the dichotomy cerebral. Benedet (1986) considers that the functional asymmetry is not conceptualized in terms dichotomy but if in terms of degrees. There isn't a dominant hemisphere in front of a silent hemisphere. Today, it is known that each hemisphere has multiple possibilities and the question is if there are aptitudes to take to processing information differences for every hemisphere. It is this aspect in which we tare going to study in depth.
Effective coverage in sensor networks: Binary integer programming formulations and heuristics

Coverage is a fundamental task in sensor networks. We present two binary integer programming models for the effective sensor placement on a grid-structured sensor field when there are more than one type of available sensors with varying sensing quality and price. The first model assumes perfect sensor detection. The second one is more realistic and gives an optimal placement strategy for probabilistic sensing. Both models suffer from the intractability of the binary integer programming formulations. We therefore suggest greedy and Lagrangean heuristics, which are both accurate and efficient. Computational results are also provided.
Remotely sensed retrieval of chlorophyll a concentration near Xiangshan sea area in Zhejiang Province with satellite HJ-1

It is very important to explore chlorophyll a concentration variation for studying typhoon by remote sensing. This paper aims to use HJ-1 satellite data of China with 30 m spatial resolution to establish the retrieval algorithm of chlorophyll a concentration and reveal chlorophyll a concentration variation, which can be used for the typhoon study in the future. The study area is near the Xiangshan sea area in Zhejiang Province, China. The band reflectance ratio of R (475) and R (560) was selected for algorithm development. Based on in situ data we established the retrieval algorithm with the correlative coefficient of 0.92(p<;0.01). The result shows that the applied result from the retrieval algorithm in satellite images of July 28, 2011 and August 20, 2011 reveal the spatial variation of chlorophyll a concentration well. In addition, HJ-1 CCD data shows good capability for ocean color research.
Towards a progressive understanding of performativity in critical management studies

A central debate in critical management studies (CMS) revolves around the concern that critical research has rather little influence on what managers do in practice. We argue that this is partly because CMS research often focuses on criticizing antagonistically, rather than engaging with managers. In light of this, we seek to re-interpret the anti-performative stance of CMS by focusing on how researchers understand, conceptualize and make use of the performative effects of language. Drawing on the works of JL Austin and Judith Butler, we put forward the concept of progressive performativity, which requires critical researchers to stimulate the performative effects of language in order to induce incremental, rather than radical, changes in managerial behaviour. The research framework we propose comprises two interrelated processes: (i) the strategy of micro-engagement, which allows critical researchers to identify and ‘ally’ with internal activists among managers, and to support their role as internal agents of change; and (ii) ‘reflexive conscientization’ − that is, a dialogic process between researchers and researched that aims to gradually raise the critical consciousness of actors in order to provide spaces in which new practices can be ‘talked into existence’ through the performative effects of language.
Mathematical Modelling of Impact of Education on Average Age at the First Marriage in Tanzania

This paper examines the impact of education on the average age at the first marriage to women in Tanzania. A mathematical model for the distribution of average age at the first marriage in Tanzania is established and the effect of education on the year at first marriage is estimated for the years 1999 and 2003/04. Both descriptive analysis and model estimate show that education level and education attainment have an impact on the average age at the first marriage. It is established that as one attains further studies, her age at first marriage is delayed. The model validation was presented graphically to illustrate the validity of the model where the proportion of ever married p ( a , x 1 , x 2 ) fitted very closely to the empirical data.
Vision-Based Human Tracking Control of a Wheeled Inverted Pendulum Robot

In this paper, a vision-based adaptive control is designed for a wheeled inverted pendulum (WIP) robot to track a moving human target by integration of multisensor data. A new algorithm is employed in the system to combine an OptiTrack camera and a Kinect camera, such that more robust and efficient performance can be achieved for human target detection and tracking. Robust adaptive control has been developed for the WIP robot to maintain its balance on two wheels and to follow the human target using visual feedback. Leader-follower control, dynamic balance control and visual tracking are efficiently combined together to achieved desired tracking and balancing performance. Extensive experiment studies have been performed to test the effectiveness of the proposed control strategies.
Nonlinear manifold learning based fault classification method

In this paper, nonlinear manifold learning is introduced into equipment fault diagnosis field and solving fault pattern classification problem, a novel method of fault classification based on manifold learning is proposed. Two nonlinear manifold learning algorithms based on LLE and Laplacian Eigenmaps are utilized to learn original fault signal directly and extract intrinsic manifold feature in data set. The new approach can greatly hold the global geometry structure information embedded in the signal, and availably overcome the flaw of general feature extraction methods which only obtain data's local linear structure, obviously improve classify performance of fault classification. The experimentations on simulation and engineering instance show that, the presented method excels compared to PCA, and is a feasibly and effective technique for fault classification.
her subject but at the same time constricted her account of the period in which Mendel actually lived.

Laughter is a ubiquitous human vocalization, a vestige of prelinguistic forms of social communication, which, if it were not so familiar, would seem rather bizarre. Why do we emit these rhythmic, raucous noises, accompanied by spasms of the diaphragm and abdominal muscles, strange facial grimaces, brightening of the eyes, and often violent rocking of the body and shaking of the extremities? In this book, Robert Provine, a biological psychologist at the University of Maryland-Baltimore County, presents the results of 10 years of exploration into this little-understood phenomenon.The book is written in a breezy, highly readable style that is aimed at the general public but is also evi- dently intended as a resource for more serious scientists. Those who are unfamiliar with the research literature on laughter and humor will find here a number of interesting observations and tidbits of infor- mation: laughter is primarily a social rather than a solitary phenomenon; in natural conversation, speakers laugh more than their audience; women laugh more at things that men say than vice versa; laughter tends to occur at the end of sentences and phrases rather than in the middle; we frequently laugh at comments that are not obviously funny; laughter is contagious; and you can't tickle yourself. Based on these and other findings relating to human (as well as chimpanzee) laughter, Provine proposes a number of hypotheses and specu- lates about the implications for our understanding of neuroscience, evolution, and human sociobiology. Unfortunately, although the aims of the book are laudable, it suffers from several limitations.The self-congratulatory and polemical tone of the book is unfortunate and rather disconcerting. From the start, we learn that Provine views himself as a pioneer, one who came to a field of study that was mired in a confusion of philosophical musings and shoddy social science methodolo- gies, and who, by taking a more sophisticated ethological and neuroscience approach, brings order and understanding to the field, making startling new
Haruspex: an image database system for query-by-examples

Describes a color-based approach to effectively resolve query-by-examples in an image database. We present a prototype database system designed to store and query a collection of ceramics. Our case study is a database of images representing ceramics from the International Museum of Ceramics in Faenza. We consider statistical features on color distribution, not requiring a strong segmentation procedure to detect the object from the background. Results on a collection of about 2000 images are reported providing a validation of the approach.
Customizable views on semantically integrated networks for systems biology

Motivation: The rise of high-throughput technologies in the post-genomic era has led to the production of large amounts of biological data. Many of these datasets are freely available on the Internet. Making optimal use of these data is a significant challenge for bioinformaticians. Various strategies for integrating data have been proposed to address this challenge. One of the most promising approaches is the development of semantically rich integrated datasets. Although well suited to computational manipulation, such integrated datasets are typically too large and complex for easy visualization and interactive exploration. Results: We have created an integrated dataset for Saccharomyces cerevisiae using the semantic data integration tool Ondex, and have developed a view-based visualization technique that allows for concise graphical representations of the integrated data. The technique was implemented in a plug-in for Cytoscape, called OndexView. We used OndexView to investigate telomere maintenance in S. cerevisiae. Availability: The Ondex yeast dataset and the OndexView plug-in for Cytoscape are accessible at http://bsu.ncl.ac.uk/ondexview. Contact: anil.wipat@ncl.ac.uk Supplementary information: Supplementary data is available at Bioinformatics online.
Translation of the human genome into clinical allergy

By complete reading of the genome sequence, in the near future we will be able to determine the role of genomic DNA sequence variation among individuals, such a single nucleotide polymorphism (SNP), in the pathogenesis of diseases and responses to drugs. Comprehension of the genome will also accelerate understanding of the transcriptome, the whole transcripts present in a cell. Messages induced by a new therapy, such as an unexpected adverse effects, will not be missed by using such a comprehensive assay. Allergic diseases will be classified into subtypes depending on the impaired or affected molecule. Herein, I introduce our research strategy for genome-wide analysis of SNP related to asthma, granted by the Millennium Genome Project of the Japanese Government, and review the recent results of transcriptome analysis using microarray technology.
The effects of exercise on cardiovascular and renal function in cardiac patients with and without heart failure.

Exercise in the upright position results in the retention of salt and water in normal subjects (1-5) and in patients with congestive failure (6). The mechanisms which set off these antidiuretic and antisaluretic responses are not definitely known. The following factors have been considered: 1) Sensory stimuli from the legs; 2) upright position; 3) hemoconcentration; 4) reduction and/or redistribution of the effective circulating blood volume; 5) metabolic products or alteration of acid-base balance; and 6) a relatively inadequate cardiac output resulting in a tendency to hypotension or collapse. Studies in this laboratory on normal subjects in the supine position showed that strenuous exercise (alternate straight leg-raising) does not regularly produce such antidiuretic and antisaluretic responses (7). In the present investigation the study was extended to include patients with valvular and nonvalvular forms of heart disease with or without congestive failure, and patients with chronic pulmonary disease with or without congestive failure, to determine: 1) Whether exercise in the supine position in these patients causes antidiuretic and antisaluretic responses; and 2) whether there is a consistent relationship between the cardiodynamic and the renal responses to such exercise.
Building Mental Muscle: Conditioning Exercises for the Six Intelligence Zones

This text uses scientific discovery to reveal how to can maximize on the extraordinary power of the human mind. Why does depression destroy memory faster than age? How can changing your facial expression actually change your mood? Why is laughter so beneficial? How does men and women's brain function differ? Why are women less likely to suffer permanent language loss from the effects of a stroke? How can nicotine benefit the brain? "Building Mental Muscle" explains the complexities in the brain in a straight-forward manner, aided by illustrations and tests, detailing how the brain processes new information, how it stores data and how it can trick us. The authors have set conditioning exercises to help sharpen up the six zones of intelligence - memory; executive/social; mathematical; language; emotional response; and spatial visualization.
Compliant layer bearings in artificial joints. Part 2: Simulator and fatigue testing to assess the durability of the interface between an elastomeric layer and a rigid substrate

Abstract Artificial joints have been much improved since their introduction but they still have a limited lifetime. In an attempt to increase their life by improving the lubrication acting within these prostheses, compliant layered polyurethane (PU) joints have been devised. These joints mimic the natural synovial joint more closely by promoting fluid film lubrication. In this study, tests were performed on compliant layer joints to determine their ability to function under a range of conditions. Both static and dynamic compression tests were undertaken on compliant artificial hip joints of two different radial clearances. Friction tests were also performed before and after static loading. In addition to this, knee wear tests were conducted to determine the suitability of a compliant layer in these applications. In the knee tests, variations in experimental testing conditions were investigated using both active and passive rotation and severe malalignment of the tibial inserts. The static compression tests together with the friction studies suggest that a small radial clearance is likely to result in ‘grabbing’ contact between the head and cup. The larger radial clearance (0.33 μm) did not exhibit these problems. The importance of the design of the compliant layer joints was highlighted with delamination occurring on the lateral bearings during the knee wear studies. The bearings with a layer 2 mm thick performed better than the bearings with a layer 3 mm thick. Tests conducted on flat PU bearings resulted in no delamination; therefore, it was concluded that the layer separation was caused by design issues rather than by material issues. It was found that, with careful material choice, consideration of design, and effective manufacturing techniques, the compliant layer joint functioned well and demonstrated durability of the union between the hard and soft layers. These results give encouragement for the suitability of these joints for clinical use.
Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications

Although glucuronidation is generally considered a detoxification route of drug metabolism, the chemical reactivity of acyl glucuronides has been linked with the toxic properties of drugs that contain carboxylic acid moieties. It is now well documented that such metabolites can reach appreciable concentrations in blood. Furthermore, they are labile, undergo hydrolysis and pH-dependent intramolecular acyl migration to isomeric conjugates of glucuronic acid, and may react irreversibly with plasma proteins, tissue proteins, and with nucleic acids. This stable binding causes chemical alterations that are thought to contribute to drug toxicity either through changes in the functional properties of the modified molecules or through antigen formation with subsequent hypersensitivity and other immune reactions. Whereas in vitro data on the toxicity of acyl glucuronides have steadily accumulated, direct evidence for their toxicity in vivo is scarce. Acyl glucuronides display limited stability, which is dependent on pH, temperature, nature of the aglycon, and so on. Therefore, careful sample collection, handling, and storage procedures are critical to ensure generation of reliable pharmacologic and toxicologic data during clinical studies. Acyl glucuronides can be directly quantified in biologic specimens using chromatographic procedures. Their adducts with plasma or cell proteins can be determined after electrophoretic separation, followed by blotting. ELISA techniques have been used to assess the presence of antibodies against acyl glucuronide–protein adducts. This review summarizes the most recent evidence concerning biologic and toxicologic effects of acyl glucuronide metabolites of various drugs and discusses their relevance for drug monitoring. A critical evaluation of the available methodology is included.
Association between subjective and objective measures of lip form and function: an exploratory analysis.

OBJECTIVE In patients with cleft lip and palate, the aims of this study were to generate objective measures of different attributes of lip movement and to explore the utility of these objective measures by examining the association between examiners' subjective assessments with the objective measures. PATIENTS AND PARTICIPANTS Thirteen patients with unilateral cleft lip and palate with varying degrees of cleft scar severity were selected. All patients had a previously repaired complete unilateral cleft lip and palate. INTERVENTIONS Photographs and videotape recordings were made of the patients with cleft at rest and during smiling. Measurements of lip movement were obtained by means of a motion analysis system. MAIN OUTCOME MEASURES The study sought to obtain rankings of cleft scar severity and impairment on a 6-point Likert scale by a lay and professional panel and measurements of displacement, asymmetry, speed, and velocity of upper lip during smiling. RESULTS Displacement was the most consistent and valid objective measurement. An objective analysis of the entire upper lip provided the most information. In general, there was a decrease in the objective measures of upper lip movement as examiners' perceptions of facial appearance or disfigurement at rest and impairment during movement became worse. This relationship was stronger for the at-rest perceptions, implying that subjective assessments should be made with the face at rest. CONCLUSIONS Objective measures provided the promise for differentiation of the components of movement and should be used to supplement subjective evaluations of lip appearance at rest and during movement.
Childhood Posttraumatic Stress Disorder: Diagnosis, Treatment, and School Reintegration

Abstract Childhood, in our culture, does not preclude exposure to trauma. Sexual abuse, physical abuse, natural disaster, urban violence, school violence, and terrorism result in significant numbers of children with posttraumatic stress disorder (PTSD) symptomatology. Many factors contribute to symptomatic expression, with some children showing few effects and others being unable to return to school. School psychologists should have a basic understanding of the impairing effects of PTSD, assessment tools, treatment options, and school reintegration planning. Specifically, this article explicates the prevalence and etiological factors related to PTSD. Assessment tools, therapeutic techniques, and school reintegration are discussed.