Miracle-dz/UniFAR-FTUs huggingface dataset:
Pneumonic-type lung adenocarcinoma presenting as non-obstructive lobar pneumonia

© 2023 Indian Chest Society | Published by Wolters Kluwer Medknow protein (CRP), which value was 15.6 mg/dl. Subsequently, a chest Computed Tomography (CT) showed some abnormal findings as shown in Figure 2. Quantiferon was negative. Sputum samples for bacterial cultures were also negative. A flexible bronchoscopy was performed where bronchial washings and bronchoalveolar lavage (BAL) were sent for common pathogens, for microscopy for acid fast bacteria (AFB), for mycobacterial culture and for cytological examination, which were all negative, as well. The patient was given empiric treatment with intravenous anti-bacterial medication with ceftriaxone and azithromycin with clinical improvement. A new chest CT in one month and reevaluation were recommended.
Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts

Abstract Background The mechanisms underlying genetic predisposition to higher body mass index (BMI) remain unclear. Methods We hypothesized that the relationship between BMI-genetic risk score (BMI-GRS) and BMI was mediated via disinhibition, emotional eating and hunger, and moderated by flexible (but not rigid) restraint within two UK cohorts: the Genetics of Appetite Study (GATE) (n = 2101, 2010–16) and the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 1679, 2014–18). Eating behaviour was measured by the Adult Eating Behaviour Questionnaire and Three-Factor Eating Questionaire-51. Results The association between BMI-GRS and BMI were partially mediated by habitual, emotional and situational disinhibition in the GATE/ALSPAC meta-mediation [standardized betaindirect 0.04, 95% confidence interval (CI) 0.02–0.06; 0.03, 0.01–0.04; 0.03, 0.01–0.04, respectively] external hunger and internal hunger in the GATE study (0.02, 0.01–0.03; 0.01, 0.001–0.02, respectively). There was evidence of mediation by emotional over/undereating and hunger in the ALSPAC study (0.02, 0.01–0.03; 0.01, 0.001–0.02; 0.01, 0.002–0.01, respectively). Rigid or flexible restraint did not moderate the direct association between BMI-GRS and BMI, but high flexible restraint moderated the effect of disinhibition subscales on BMI (reduction of the indirect mediation by -5% to -11% in GATE/ALSPAC) and external hunger (-5%) in GATE. High rigid restraint reduced the mediation via disinhibition subscales in GATE/ALSPAC (-4% to -11%) and external hunger (-3%) in GATE. Conclusions Genetic predisposition to a higher BMI was partly explained by disinhibition and hunger in two large cohorts. Flexible/rigid restraint may play an important role in moderating the impact of predisposition to higher BMI.
Synthesizing Samples fro Zero-shot Learning

Zero-shot learning (ZSL) is to construct recognition models for unseen target classes that have no labeled samples for training. It utilizes the class attributes or semantic vectors as side information and transfers supervision information from related source classes with abundant labeled samples. Existing ZSL approaches adopt an intermediary embedding space to measure the similarity between a sample and the attributes of a target class to perform zero-shot classification. However, this way may suffer from the information loss caused by the embedding process and the similarity measure cannot fully make use of the data distribution. In this paper, we propose a novel approach which turns the ZSL problem into a conventional supervised learning problem by synthesizing samples for the unseen classes. Firstly, the probability distribution of an unseen class is estimated by using the knowledge from seen classes and the class attributes. Secondly, the samples are synthesized based on the distribution for the unseen class. Finally, we can train any supervised classifiers based on the synthesized samples. Extensive experiments on benchmarks demonstrate the superiority of the proposed approach to the state-of-the-art ZSL approaches.
Research on the streak tube three-dimensional imaging method based on compressive sensing

Abstract. Streak tube imaging lidar has been widely applied in target recognition and imaging because of its high accuracy and frame rate. Compressed ultrafast photography technique employs a digital micromirror device (DMD) and a streak camera. It is developed to satisfy the requirements of imaging of ultrafast processes. The concept of structure provides a new direction for three-dimensional (3-D) imaging. This paper studies the streak tube 3-D imaging system based on compressive sensing (CS) from the perspective of imaging system construction and image reconstruction algorithms. The system model is built, and mainly structures are introduced such as the fiber array and DMD. Two simulation experiments are organized. First, the stripe images of a simple target are obtained. In the process of reconstructing the intensity image and range image, the extraction methods of the measurement matrix required by the CS algorithm are given, respectively. The resulting images and variance curve show that the image quality increases with the number of measurements. The second experiment with a complex target is carried out. Two levels of distance interval are used to analyze the imaging effect in the simulation. It is found that the image resolution is directly related to the distance interval selection.
What Physical World Do We Live in

It is shown that the hypothesis of Monoverse relevant to the existing version of the special relativity theory is incorrect. Incorrect is also the existing version of the special relativity theory itself. Its revised version, the relativistic formula of which allows to propose the hypothesis of hidden Multiverse is presented. The hypothesis of hidden Multiverse is based on a proof by the author general scientific principle of physical reality of imaginary numbers. It is shown that this hypothesis, unlike many other hypotheses of Multiverse and the hypothesis of Monoverse, is already verifiable. And the experimental proof of the reality of the hidden Multiverse existence is a phenomenon of dark matter and dark energy. Other possible experimental proof of that is proposed as well. As a result, the data processing is obtained by WMAP and Planck spacecrafts, and the structure of hidden Multiverse is determined, which has proved to be a quaternion, and its parameters are defined. According to these calculations, the hidden Multiverse contains from twenty to twenty-two parallel universes, five-six neighboring universes of which constitute dark matter, and the rest parallel universes constitute dark energy. Moreover, it is shown that our hidden Multiverse neighbors with other hidden Multiverses, inaccessible to our observations not only by electromagnetic but also by gravitational manifestations, which together form a Supermultiverse.
College transition Fall 2020 and 2021: Understanding the relationship of COVID-19 experiences and psychosocial correlates with anxiety and depression

Rates of mental health symptoms, particularly anxiety and depression, have increased significantly in college students in the past decade along with utilization of mental health resources. The COVID-19 pandemic created an additional source of stressors to an already challenging landscape of college transition. COVID-19 has been associated with an increase of anxiety among college students, particularly first year students, entering college in Fall 2020. The shifts in policy (e.g., federal, state, and college) accruing medical data, and vaccine availability between Fall 2020 and Fall 2021 provide an opportunity to examine the role of COVID-19 experiences in the transition to college for these two first-year student cohorts. This study examined two cohorts of first-year students, Fall 2020 and 2021, to better understand the relationship between COVID-19 experiences, psychosocial correlates, and mental health symptoms. Results suggest that for students in our Fall 2020 cohort COVID-19 experiences played a distinct role in the prediction of mental health symptoms while in Fall 2021 COVID-19 experiences did not uniquely contribute to prediction of mental health symptoms. These findings have implications for mental health interventions for first-year students transitioning to college.
Genotype by environment interaction and heteroscedasticity influence the expression of parasite resistance in Katahdin sheep

Abstract Increasingly, sheep producers are choosing breeds that express resistance to gastrointestinal parasites due to reduced efficacy of anthelminthic drugs. One such breed is Katahdin. Katahdins are raised in various climates and management systems in the United States, which can be combined into eco-management clusters to describe production environments more holistically. The objectives of this study were to determine if genotype by environment interaction (G × E) and heteroscedasticity existed across these eco-management clusters for traits indicative of parasite resistance. Body weights (BW), FAMACHA scores (FAM), and fecal egg counts (FEC) were collected at around 90 d in 3,527 Katahdin lambs delineated into nine eco-management clusters. A tri-variate animal model including birth-rearing type, sex, and dam age (as a quadratic covariate) as fixed effects, and eco-management cluster, direct additive, uncorrelated maternal environmental (for BW), and residual as random effects, was fitted with ASReml. Heritability estimates for BW, FEC, and FAM were 0.36 ± 0.07, 0.31 ± 0.07, and 0.26 ± 0.05, respectively. The genetic (additive) correlation between BW with FEC was −0.26 ± 0.08 and with FAM was −0.16 ± 0.08, and thereby favorable. Heritabilities were also estimated univariately within eco-management clusters and ranged from 0.30 ± 0.05 to 0.37 ± 0.05 for BW, 0.18 ± 0.12 to 0.50 ± 0.13 for FEC, and 0.07 ± 0.06 to 0.40 ± 0.19 for FAM. Significant genetic and phenotypic heteroscedasticity among eco-management clusters was detected in FEC and FAM. A sire by eco-management cluster interaction term was added to the initial model fitted to evaluate G × E. This interaction defined substantial variation (P < 0.01) in all traits and explained 12% (FEC) to 20% (BW) of the phenotypic variation. Accounting for G × E and heteroscedasticity in the design and implementation of breeding programs may introduce operational challenges. Still, doing so would improve the efficacy of selection programs to improve parasite resistance.
The Two Beam Acceleration Staging Experiment at Argonne Wakefield Accelerator Facility

Staging, defined as the accelerated bunch in a wakefield accelerator continues to gain energy from sequential drive bunches, is one of the most critical technologies, yet be demonstrated, required to achieve high energy. Using the Two Beam Acceleration (TBA) beamline at Argonne Wakefield Accelerator (AWA) facility, we will perform a staging experiment using two X-band TBA units. The experiment is planned to conduct in steps. We report on the most recent progress. STAGING EXPERIMENT AT AWA Linear colliders based on two-beam wakefield acceleration have a modular design [1]. A fundamental requirement of two beam wakefield acceleration that has yet to be demonstrated is the staging of sequential accelerating modules. For a successful staging demonstration two key issues need to be addressed: drive beam separation and the timing between wakefields from different stages and the accelerated (witness) beam. In many approaches a fast deflector is required to direct beams from a drive bunch train into separate power extractor units feeding sequential accelerating stages for a witness beam. In the case of an L-band driver at the AWA the drive beam spacing is 50 ns. Stripline kickers or RF deflecting cavities can be used as fast deflectors on this time scale. We propose to use a standard strip line kicker for this proposal. Another important issue for a staging demonstration is ability to synchronize the witness beam with the wakes generated in different stages. The solution considered up to now has been to bend the drive beam, which raised questions about the energy loss and beam degradation caused by coherent synchrotron radiation. Here we propose a new design based on the time delay of RF pulses in different stages with respect to the witness beam. This approach eliminates the need to bend a high charge beam 180 degrees. For the design of the RF delay line one has to consider two factors: line length and attenuation. Demonstration of wakefield acceleration staging is the next big step towards validation of the approach as a whole. It proves that wakefield acceleration is indeed possible in a modular way. Once staging is demonstrated one can achieve TeV energies by stacking these modules. This approach allows for length reduction of the accelerator, as wakefield acceleration yields a high gradient operation in a short pulse mode.
Comparison of drug‐coated balloon angioplasty versus common balloon angioplasty for arteriovenous fistula stenosis: A systematic review and meta‐analysis

Drug‐coated balloons (DCBs) have been used in dialysis patients with arteriovenous fistula (AVF) stenosis, but whether DCBs have advantages over ordinary balloons is still controversial. A meta‐analysis was designed to investigate the safety and efficacy of DCBs and common balloons (CBs) in the treatment of AVF stenosis. We searched the PubMed, EMBASE, and China National Knowledge Internet (CNKI) databases for randomized controlled trials that evaluated the comparison of DCB angioplasty versus CB angioplasty for AVF stenosis in dialysis patients and reported at least one outcome of interest. The results showed that the DCB group had a higher first‐stage patency rate of the target lesion 6 months [odds ratio, OR = 2.31, 95% confidence interval, CI: (1.69, 3.15), p < . 01] and 12 months [OR = 2.09, 95% CI: (1.50, 2.91), p < . 01] after surgery. There was no statistically significant difference in all‐cause mortality between the two groups at 6 months [OR = 0.85, 95% CI: (0.47, 1.52), p = . 58] and 12 months [OR = 0.99, 95% CI: (0.60, 1.64), p = . 97]. Compared with CB, DCBs as a new endovascular treatment for AVF stenosis have a higher primary patency rate of target lesions and can delay the occurrence of restenosis. There is no evidence that DCB can increase the mortality of patients.
The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs

ABSTRACT BECN2 is a mammal-specific homolog of BECN1. Both proteins serve as a scaffolding molecule in the class III phosphatidylinositol 3-kinase complex (PtdIns3K) to promote macroautophagy/autophagy and endolysosomal trafficking. Our previous studies have shown that the BECN1 coiled-coil domain forms a metastable homodimer and readily self-dissociate to form the BECN1-ATG14 or BECN1-UVRAG coiled-coil complex as part of the scaffolding “arm” of the PtdIns3K complex. Here we report the crystal structure of the BECN2 coiled-coil domain, which forms a metastable homodimer similar to BECN1 but shows reduced stability and large deviation from the ideal coiled-coil geometry due to extra “imperfect” residues. We also report the crystal structure of BECN2-ATG14 coiled-coil complex, which is structurally similar to the BECN1-UVRAG coiled-coil complex we reported previously but functionally distinct. The potent BECN2-ATG14 interaction is selectively critical for endolysosomal degradation of the GPRASP1-associated DRD2/D2R but shows limited effect on EGFR, a cargo that depends on the BECN1-UVRAG interaction. We designed stapled peptides that selectively interacted with the BECN2 coiled-coil domain to enhance the BECN2-ATG14 or BECN1-UVRAG interaction. One such peptide specifically promoted BECN2-dependent processes including autophagy and endolysosomal degradation of DRD2/D2R but did not affect BECN1-dependent EGFR degradation. Our findings suggest that, despite high sequence identity to BECN1, BECN2 coiled-coil domain has unique structural features and the BECN2-ATG14 interaction selectively promotes autophagic or endolysosomal degradation of BECN2-specific cargos including GPRASP1-associated GPCRs. Abbreviations AMBRA1 autophagy and beclin 1 regulator 1; ATG14 autophagy related 14; ATG5 autophagy related 5; ATG7 autophagy related 7; BECN1 beclin 1; BECN2 beclin 2; CC coiled-coil; CQ chloroquine CNR1/CB1R cannabinoid receptor 1 DAPI 4ʹ,6-diamidino-2-phenylindole; dCCD delete CCD; DRD2/D2R dopamine receptor D2 GPRASP1/GASP1 G protein-coupled receptor associated sorting protein 1 GPCR G-protein coupled receptor; ITC isothermal titration calorimetry; IP immunoprecipitation; KD knockdown; KO knockout; MAP1LC3/LC3 microtubule associated protein 1 light chain 3; NRBF2 nuclear receptor binding factor 2; OPRD1/DOR opioid receptor delta 1 PIK3C3/VPS34 phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3R4/VPS15 phosphoinositide-3-kinase regulatory subunit 4; PtdIns3K class III phosphatidylinositol 3-kinase; PtdIns3P phosphatidylinositol-3-phosphate; RUBCN rubicon autophagy regulator; SQSTM1/p62 sequestosome 1; UVRAG UV radiation resistance associated; VPS vacuolar protein sorting; WT wild type.
Pulmonary artery diameter correlates with echocardiographic parameters of right ventricular dysfunction in patients with acute pulmonary embolism

Introduction: Right ventricular dysfunction (RVD) is a key component in the process of risk stratification in patients with acute pulmonary embolism (PE). Echocardiography remains the gold standard for RVD assessment, however, measures of RVD may be seen on CTPA imaging, including increased pulmonary artery diameter (PAD). The aim of our study was to evaluate the association between PAD and echocardiographic parameters of RVD in patients with acute PE. Methods: Retrospective analysis of patients diagnosed with acute PE was conducted at large academic center with an established pulmonary embolism response team (PERT). Patients with available clinical, imaging, and echocardiographic data were included. PAD was compared to echocardiographic markers of RVD. Statistical analysis was performed using the Student's t test, Chi-square test, or one-way analysis of variance (ANOVA); P < 0.05 was considered statistically significant. Results: 270 patients with acute PE were identified. Patients with a PAD >30 mm measured on CTPA had higher rates of RV dilation (73.1% vs 48.7%, P < 0.005), RV systolic dysfunction (65.4% vs 43.7%, P < 0.005), and RVSP >30 mmHg (90.2% vs 68%, P = 0.004), but not TAPSE ≤1.6 cm (39.1% vs 26.1%, P = 0.086). A weak increasing linear relationship between PAD and RVSP was noted (r = 0.379, P = 0.001). Conclusions: Increased PAD in patients with acute PE was significantly associated with echocardiographic markers of RVD. Increased PAD on CTPA in acute PE can serve as a rapid prognostic tool and assist with PE risk stratification at the time of diagnosis, allowing rapid mobilization of a PERT team and appropriate resource utilization.
The dimensional calibration of piston-cylinder units to be used for pressure metrology and the re-determination of the Boltzmann constant

Measurement procedures for the dimensional calibration of piston-cylinder type primary pressure standards which are intended to be used in a project for the re-determination of the Boltzmann constant are described. A numerical post-processing procedure is described to generate precise three-dimensional data sets from the 1D data sets. These data sets are required for the effective area determination of the pressure standards. Typical measurement results are discussed.
Weak pseudo-BCK algebras

Abstract In this paper we define and study the weak pseudo-BCK algebras as generalizations of weak BCK-algebras, extending some results given by Cı⃖rulis for weak BCK-algebras. We give some characterizations of weak pseudo-BCK algebras and we prove that a weak pseudo-BCK algebra satisfying the right distribution laws is a BCK-algebra. We define the class of commutative weak pseudo-BCK algebras, and we give equivalent definitions and characterization theorems for commutative weak pseudo-BCK algebras. The classes of quasi pseudo-BCK algebras and weak pseudo-BCK(E) algebras are introduced and a characterization theorem for quasi pseudo-BCK algebras is given. We prove that any weak pseudo-BCK(E) algebra is a pseudo-BE algebra and the class of commutative weak pseudo-BCK(E) algebras is equivalent to the class of commutative pseudo-BCK algebras.
Cathepsin L regulates oocyte meiosis and preimplantation embryo development

Early embryonic loss, caused by reduced embryo developmental competence, is the major cause of subfertility in humans and animals. This embryo developmental competence is determined during oocyte maturation and the first embryo divisions. Therefore, it is essential to identify the underlying molecules regulating these critical developmental stages. Cathepsin L (CTSL), a lysosomal cysteine protease, is involved in regulating cell cycle progression, proliferation and invasion of different cell types. However, CTSL role in mammalian embryo development is unknown. Using bovine in vitro maturation and culture systems, we show that CTSL is a key regulator for embryo developmental competence. We employed a specific CTSL detection assay in live cells to show that CTSL activity correlates with meiotic progression and early embryo development. Inhibiting CTSL activity during oocyte maturation or early embryo development significantly impaired oocyte and embryo developmental competence as evidenced by lower cleavage, blastocyst and hatched blastocyst rates. Moreover, enhancing CTSL activity, using recombinant CTSL (rCTSL), during oocyte maturation or early embryo development significantly improved oocyte and embryo developmental competence. Importantly, rCTSL supplementation during oocyte maturation and early embryo development significantly improved the developmental competence of heat‐shocked oocytes/embryos which are notoriously known for reduced quality. Altogether, these results provide novel evidence that CTSL plays a pivotal role in regulating oocyte meiosis and early embryonic development.
Perceptions and Attitudes toward a Proposed Digital Health Physical Activity Program among Older Family Caregivers of Persons with Heart Failure: A Qualitative Study

ABSTRACT Tailored physical activity (PA) programs using digital health technologies in the home can promote family caregivers’ (FCGs) physical function and psychological wellbeing. However, there is a gap in research for digital health PA interventions targeting older FCGs of persons with HF (HF-FCGs). The burden of caregiving for persons with HF may displace the FCG’s self-care, including PA. Therefore, we examined older HF-FCGs’ perceptions and attitudes toward three technology components (video-conferencing, fitness tracker, text messaging) that would be most useful in delivering a digital health PA program. Interviews were conducted with 13 HF-FCGs (≥65 years old) between January and April 2021. Directed content analysis was used and the analysis was guided by the adapted unified theory of acceptance and use of technology (UTAUT) model. In addition to HF-FCGs’ perceptions and attitudes toward each technology component in each construct of the adapted UTAUT model (ease of use, usefulness, facilitating conditions), three additional factors were associated with intention to use technology. These were: (1) HF patients’ positive experience, (2) digital skills, and (3) quality of internet connectivity. The findings provide digital health requirements for design and modification of a technology-supported PA program that engages older FCGs who care for persons with HF.