Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity and reliability of the Neurobehavioral Evaluation of Infant Development (VANEDELA). Screening Instrument from one to 24 months in primary health care in Mexico

Introduction. Early identification of developmental delays or disabilities in children is a challenge and a global concern. In Mexico, the prevalence of childhood disability is 6%, and it is estimated that 25% of the unattended delays will have consequences on their potential. VANEDELA is a rapid screening test to detect and prevent developmental disorders in primary health care. Objective. To determine the external validity and test-retest reliability of the behavioral (DB) and reflex (DR) developmental formats of the VANEDELA screening test, compared with the diagnostic test of Gesell’s Developmental Schedule Test. Method. Descriptive, transversal, and prospective study in 379 infants aged one to 24 months attending the Neurodevelopment Monitoring Laboratory / INP and the ISSSTE Tlalpan Family Medicine Clinic from 2011 to 2014. Measurements: A set of four aspects was evaluated including validity by external criteria: sensitivity, specificity, positive-negative predictive criteria, and test-retest reliability. Results. In the DB format, we found a 79% - 89% sensitivity (S) and a 83% - 95% specificity (Sp). In the DR format, a 18% - 35% sensitivity and a 81% - 96% specificity were found. Using both DB-DR formats, we found a 82% - 89% sensitivity and 72% to 91% specificity, and a test-retest reliability . 62-1. Discussion and conclusion. The VANEDELA increased its validity parameters with respect to the previous assessment with adequate stability. The DB formats and the DB-DR combination of VANEDELA have an adequate validity based on external criteria, making them suitable for use in primary health care.
The Empathy Enigma: An Empirical Study of Decline in Empathy among Undergraduate Nursing Students

The purpose of this study was to examine changes in empathy during an academic year among undergraduate nursing students. The research followed a descriptive methodology with a sample of 214 undergraduate nursing students who completed the Jefferson Scale of Empathy at the beginning and at the end of 2006-2007 academic year. Data were collected using a questionnaire. Results showed a statistically significant decline of empathy for nursing students who were exposed more than others to patient encounters during study period (F (2, 211) = 4.2, p< 0.01). Findings were consistent with those found among medical students in that nursing students' encounters with patients, though not very clear on those who had less encounters with clients. The authors suggested that changes to the modalities of teaching may be contributing a disconnect in human connections, due to an emphasis on self-directed and simulated learning experiences. Further studies to identify whether findings of the research impacted on patient outcomes and nurse-students were recommended.
Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions

Sequence analysis of chromosome IX of Saccharomyces cerevisiae revealed an open reading frame of 166 residues, designated TPM2, having 64.5% sequence identity to TPM1, that encodes the major form of tropomyosin in yeast. Purification and characterization of Tpm2p revealed a protein with the characteristics of a bona fide tropomyosin; it is present in vivo at about one sixth the abundance of Tpm1p. Biochemical and sequence analysis indicates that Tpm2p spans four actin monomers along a filament, whereas Tpmlp spans five. Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis. Loss of Tpm2p has no detectable phenotype in otherwise wild type cells, but is lethal in combination with tpm1 delta. Over-expression of Tpm2p does not suppress the growth or cell surface targeting defects associated with tpm1 delta, so the two tropomyosins must perform an essential function, yet are not functionally interchangeable. S. cerevisiae therefore provides a simple system for the study of two tropomyosins having distinct yet overlapping functions.
Post-bond test techniques for TSVs with crosstalk faults in 3D ICs

Three-dimensional (3D) integration is expected to cope with the difficulties faced by current 2D system-on-chip designs using through silicon via (TSV). However, coupling capacitance exists between two neighboring TSVs such that TSVs are prone to crosstalk faults. In this paper, we propose a builtin self-test (BIST) scheme for the post-bond test of TSVs with crosstalk faults in 3D ICs. A test algorithm for testing crosstalk faults of TSVs is proposed. The proposed BIST scheme has the feature of low area cost. Simulation results show that the area overhead of the BIST circuit implemented with 90nm CMOS technology for a 512×16 TSV array in which each TSV cell size is 15 × 15μm2 is 6.7%.
EXPERT GROUP STUDY ON RECOMMENDED PRACTICES 13. WIND ENERGY PROJECTS IN COLD CLIMATES

FOREWORD The International Energy Agency Implementing Agreement for Cooperation in the Research, Development and Deployment of Wind Energy Systems (IEA Wind) is a vehicle for member countries to exchange information on the planning and execution of national, large-scale wind system projects and to undertake cooperative research and development projects called Tasks or Annexes. As a final result of research carried out in the IEA Wind Tasks, Recommended Practices, Best Practices, or Expert Group Reports may be issued. These documents have been developed and reviewed by experts in the specialized area they address. They have been reviewed and approved by participants in the research Task, and they have been reviewed and approved by the IEA Wind Executive Committee as guidelines useful in the development and deployment of wind energy systems. Use of these documents is completely voluntary. However, these documents are often adopted in part or in total by other standards-making bodies. A Recommended Practices document includes actions and procedures recommended by the experts involved in the research project. A Best Practices document includes suggested actions and procedures based on good industry practices collected during the research project. An Experts Group Studies report includes the latest background information on the topic as well as a survey of practices, where possible. PREFACE Numerous cold climate sites around the world offer great wind energy potential in demanding winter climates. Activities have been conducted in a number of countries to master the difficulties that atmospheric icing and low temperatures pose for wind energy technology. The current wind capacity in cold climates (defined as those that experience either icing events or temperatures lower than the operational limits of standard wind turbines) in Scandinavia, North America, Europe, and Asia, is about 60 GW. Increased experience, knowledge, and improvements in cold climate technology have enabled the economics of wind projects to become more competitive in relation to standard wind projects. The internationally accepted procedures for testing and evaluating wind turbines or wind energy conversion systems encompass a variety of aspects. Although there is vast wind energy potential in cold climates, little attention has so far been paid to the environmental impacts of wind projects in these areas. The large-scale exploitation of cold climate sites has been limited by our lack of knowledge about their special challenges and the lack of proven and economical technological solutions. The purpose of this report is to provide the best available recommendations …
DESIGN OF HIGH SPEED SINE WAVE FLASH ADC FOR UWB APPLICATIONS

Multigigahertz flash ADC is limited by sampling clock timing jitter. Since it is used in high frequency applications it is essential to remove jitter effects which will reduce the efficiency of ADC. This paper describes the effect of clock transition time on the spurious free dynamic range of a CMOS sample and hold circuit. To improve SFDR the effect of finite clock transition time of the signal and sinusoidal signal sampling clock are considered that is mainly based on signal dependent non linearity model. Where a square wave clock exhibits a shorter transition time but more jitter susceptibility, sinusoidal clocking provides a longer transition time but shorter jitter spectrum. To verify this concept a 6GS/s, 4b flash ADC is designed along with this interpolation technique is added in order to reduce the power consumption achieving effective number of bits of 3.93 bits with a SNR of 22.9dB. GENERAL TERMS: Flash ADC, ENOB, SNR, SFDR, Jitter
A Language-Action Approach to Electronic Negotiations

The current state-of-the-art in electronic negotiations shows a focus on the trade of standardised mostly inexpensive products in fixed networks of suppliers and customers. To overcome these shortcomings, the goal must be to enable the trade of complex and valuable goods and to support many-to-many marketplace for that purpose. Once valuable goods are concerned, the trade process involves negotiations which consist of a number of communicative exchanges. The Language-Action Perspective has proved to be relevant for the analysis and modelling of communication acts. We will show that a LAP approach is indeed useful as the basis for complex negotiations but only if combined with other theoretical and conceptual foundations.
Aspect based Sentiment Analysis using support vector machine classifier

Sentiment Analysis involves the process of identifying the polarity of opinionated texts. Lots of social networking sites are being used for expressing thoughts and opinions by users to rate products. These user opinionated text is highly unstructured in nature and thus involves the application of various natural language processing techniques. In aspect based sentiment analysis, the various features of a product is identified through the training process. For e.g. the aspects of a camera are picture quality, size, resolution etc. The quantitative analysis of each aspect is done using support vector machine classifier. In most of the previous works, a product review is analysed as a whole rather than considering each aspect of it. Aspect based opinion mining is tedious since the identification of individual features is in itself a challenging task.
A trispecies Aspergillus microarray: Comparative transcriptomics of three Aspergillus species

The full-genome sequencing of the filamentous fungi Aspergillus nidulans, Aspergillus niger, and Aspergillus oryzae has opened possibilities for studying the cellular physiology of these fungi on a systemic level. As a tool to explore this, we are making available an Affymetrix GeneChip developed for transcriptome analysis of any of the three above-mentioned aspergilli. Transcriptome analysis of triplicate batch cultivations of all three aspergilli on glucose and xylose media was used to validate the performance of the microarray. Gene comparisons of all three species and cross-analysis with the expression data identified 23 genes to be a conserved response across Aspergillus sp. , including the xylose transcriptional activator XlnR. A promoter analysis of the up-regulated genes in all three species indicates the conserved XlnR-binding site to be 5′-GGNTAAA-3′. The composition of the conserved gene-set suggests that xylose acts as a molecule, indicating the presence of complex carbohydrates such as hemicellulose, and triggers an array of degrading enzymes. With this case example, we present a validated tool for transcriptome analysis of three Aspergillus species and a methodology for conducting cross-species evolutionary studies within a genus using comparative transcriptomics.
Spitzer 24 μm Time Series Observations of the Eclipsing M Dwarf Binary GU Boötis

We present a set of Spitzer 24 μm MIPS time series observations of the M dwarf eclipsing binary star GU Boötis. Our data cover three secondary eclipses of the system: two consecutive events and an additional eclipse 6 weeks later. The study’s main purpose is the long-wavelength (and thus limb-darkening-independent) characterization of GU Boo’s light curve, allowing for independent verification of the results of previous optical studies. Our results confirm previously obtained system parameters. We further compare GU Boo’s measured 24 μm flux density to the value predicted by spectral fitting and find no evidence for circumstellar dust. In addition to GU Boo, we characterize (and show examples of) light curves of other objects in the field of view. Analysis of these light curves serves to characterize the photometric stability and repeatability of Spitzer’s MIPS 24 μm array over short (days) and long (weeks) timescales at flux densities between approximately 300 and 2000 μJy. We find that the light-curve rms about the median level falls into the 1%-4% range for flux densities higher than 1 mJy. Finally, we comment on the fluctuations of the 24 μm background on short and long timescales.
Investigating the effects of psychological empowerment and interpersonal conflicts on employees' knowledge sharing intentions

PurposeThe purpose of this paper is to investigate how different forms of interpersonal conflicts and employees’ psychological empowerment may affect knowledge sharing intentions directly or indirectly via interpersonal trust in the workplace.Design/methodology/approachSurvey data collected from 249 employees of 37 of the top 500 corporations in the manufacturing industry in Taiwan were used for the data analysis. The research model was analyzed using the component-based structural equation modeling technique, namely, the partial least squares (PLS) approach.FindingsThe results indicate that both relationship and task conflicts have significant indirect effects on employees’ knowledge sharing intentions via psychological empowerment and trust. Additionally, psychological empowerment significantly influences employees’ knowledge sharing intentions both directly and indirectly via trust.Research limitations/implicationsThe primary theoretical implication is an advancement in the understanding of the critical antecedents of and their different effects on employees’ knowledge sharing intentions from the perspectives of conflict management and individual psychological empowerment. Future research may concentrate on investigating the bidirectional interactions among trust, relationship conflicts and task conflicts in different knowledge-sharing contexts.Practical implicationsThis study provides practical insights into conflict resolution intended to facilitate psychological empowerment and interpersonal trust that encourage knowledge sharing in the workplace.Originality/valueTo the best of the authors’ knowledge, this study is the first knowledge sharing study that empirically examines how task and relationship conflicts affect employees’ knowledge sharing intentions differently via the mediation of their perceived psychological empowerment and interpersonal trust in one another in the workplace.
Class Structure and Economic Growth: India and Pakistan since the Mughuls

1. Introduction 2. The Moghul Economy and Society 3. The Economic and Social Impact of Colonial Rule 4. The Social Origins and Ideology of the Nationalist Movement 5. Reasons for the Acceleration of Economic Growth Since Independence 6. The Social Impact of India's 'Socialist Pattern' 7. The Social Impact of Pakistan's 'Functional Inequality'
COMBINING MEDICINAL CHEMISTRY WITH CHEMOGENOMIC AND COMPUTER-AIDED STRUCTURE-BASED DESIGN IN DEVELOPMENT OF NOVEL KINASE INHIBITORS

Although only 6% of the estimated 518 protein kinases [1] encoded in the human genome have had structures of their catalytic domains determined by Xray crystallography, structure-based design techniques can significantly aid in the discovery of novel kinase inhibitors across this protein class. Conservation of the ATP binding site between known kinase structures, together with knowledge of the human kinase genome and an abundance of selectivity data, allows for significant advances in understanding the relationship between kinase targets and inhibitors. Utilization of this information in discovery of kinase inhibitors defines practical chemogenomics [2]. Chemogenomics technologies at Lilly aid in lead generation strategies and in making informed decisions about advancement of chemical entities in the drug discovery pipeline. In turn, computational docking and scoring, aided by X-ray crystallography, is used to optimize chemical series discovered with the aid of chemogenomics . In this paper we present the Lilly Kinase portal and show examples of two projects that highlight the utility of integrated technologies. Specific examples include novel classes of kinase inhibitors directed at CDK2 and TGFBR1 kinases. The implementation of a strategy of compound profiling across a kinase panel led to the identification of a group of benzimidazole s as inhibitors of several kinases. This finding led to the evaluation of aminoimidazo[ 1,2-a]pyridine [3] as a potentially novel ATP-competitive CDK2 inhibitor. Our exploration hypothesis was guided by docking experiments [4] that correctly predicted the binding mode of these compounds. Chemogenomic tools provided direction for selectivity exploration and determined a primary focused-kinase selectivity panel for the project. The hypothesis was tested through both SAR studies and X-ray crystallographic analysis. An initial lead against CDK2 with a potency of 320 nM was optimized to achieve a 28 nM inhibitor with improved cyclin selectivity and high selectivity against a representative set of other serine/threonine kinases. This compound selectively inhibited the CDK2dependent phosphorylation of Rb in HCT116 tumor cells and showed an IC50 for growth inhibition of 0.21 uM after a 72 hour exposure. Another application in the use of integrated technologies was used to discover a group of aryl- and heteroaryl-substituted pyrazole inhibitors of the TGFBR1 kinase [5]. In this case, our efforts began with the in vitro screening of a large library of compounds. SAR exploration of identified diheteroaryl-substituted
How does market orientation affect business relationships

Many studies have shown that market orientation is important for firms because it has a positive impact on performance. However, several studies have indicated that the relation between a firm’s market orientation and its success is sometimes weak and that moderating variables need to be considered at least under certain circumstances. As such the overall message from the market orientation studies is not clear. The usefulness of the market orientation concept must be also questioned when looking at the realities of business markets. In most if not all cases the firms’ “surroundings” should be seen as a network of interorganizational relationships rather then an anonymous market. Therefore, in this paper the notion of market orientation is explored with particular focus on inter-organizational relationships. Hereby, it is argued that the relationships are important and that the overall market orientation of firms needs to be translated to a relationship level in order to be effective. It is further argued that market orientation on a relationship level can be interpreted in terms of a firm's employed resources and executed activities dedicated to relational exchange processes.
Mixed-ligand Complexes of Copper(ii) with A-hydroxycarboxylic Acids and 1,10-phenanthroline Dedicated to Professor Kurt Dehnicke on the Occasion of His 70th Birthday

Eight new two-ligand complexes of copper(II) with 1,10-phenanthroline and one of four different a-hydroxy-carboxylic acids (glycolic, lactic, mandelic and benzylic) were prepared. The complexes of general formula [Cu(HL) 2-(phen)] ´ nH 2 O (HL = monodeprotonated acid) (1±4) were characterized by elemental analysis, IR, electronic and EPR spectroscopy, magnetic measurements and thermo-gravimetric analysis. The complexes of general formulae [Cu(HL)(phen) 2 ](HL) ´ H 2 L ´ nSolv [1 a (HL = HGLYO ± , n = 1, Solv = MeCN) and 3 a (HL = HMANO ± , n = 0)] and [Cu(L)(phen)(OH 2)] ´ nH 2 O [2 a (L = LACO 2± , n = 4) and 4 a (L = BENO 2± , n = 2)] were characterized by X-ray dif-fractometry. In all these latter a pentacoordinated copper atom has a basically square pyramidal coordination polyhe-dron, the distortion of which towards a trigonal bipyramidal configuration has been evaluated in terms of the parameter s. In 1 a and 3 a there are three forms of a-hydroxycarboxylic acid: a monodentate monoanion, a monoanionic counterion, and a neutral molecule lying in the outer coordination sphere; in 2 a and 4 a the a-hydroxycarboxylic acid is a bi-dentate dianion coordinating through carboxyl and hydroxyl oxygens. Gemischtliganden-Komplexe von Kupfer(II) mit a-Hydroxycarbonsa È uren und 1,10-Phenanthrolin Inhaltsu È bersicht. Acht neue Zweiligand-Komplexe von Kup-fer(II) mit 1,10-Phenanthrolin und einer von vier a-Hydro-xycarbonsa È uren (Glykol-, Milch-, Mandel-, Benzilsa È ure) wurden dargestellt. Die Komplexe mit der allgemeinen For-mel [Cu(HL) 2 (phen)] ´ nH 2 O (HL = monodeprotonierte Sa È ure) (1±4) wurden elementaranalytisch, durch IR-, UV/ Vis-und EPR-Spektroskopie, magnetische Messungen sowie thermogravimetrisch charakterisiert. Die Komplexe [Cu(HL)(phen) 2 ](HL) ´ H 2 L ´ nSolvens [1 a (HL = HGLYO ± , n = 1, Solvens = MeCN) und 3 a (HL = HMNO ± , n = 0] und [Cu(L)(phen)(OH 2)] ´ nH 2 O [2 a (L = LACO 2± , n = 4) und 4 a (L = BENO 2± , n = 2)] wurden ro È ntgenographisch charak-terisiert. In allen letztgenannten Komplexen bildet das fu È nf-fach koordinierte Kupferatom ein im wesentlichen quadra-tisch-pyramidales Koordinationspolyeder, die Verzerrung zu einer trigonal-bipyramidalen Konfiguration wird u È ber den Parameter s definiert. In 1 a und 3 a liegen die a-Hydroxy-carbonsa È ure in drei Formen vor: als einza È hniges Monoanion, als monoanionisches Gegenion und als neutrales Moleku È l in der …
An Innovative Rapid Processor Platform Design for Early Engineering Education

A new course for the early stage of digital design education is demonstrated. An innovative usage of technologies and an effective organization of numerous subjects to leverage the current classroom practices are presented. In particular, the new course objectives and organization are explained to provide an overall view and details of our rapid design process, as well as to achieve engineering educational goals for reducing a gap between the technologies used in industry and in academia. Expected impacts on realistic, pre-industrial experiences at the early stage of engineering education are also discussed.