Miracle-dz/UniFAR-FTUs huggingface dataset:
Avian WNT4 in the Female Reproductive Tracts: Potential Role of Oviduct Development and Ovarian Carcinogenesis

The wingless-type MMTV integration site family of proteins (WNTs) is highly conserved secreted lipid-modified signaling molecules that play a variety of pivotal roles in developmental events such as embryogenesis, tissue homeostasis and cell polarity. Although, of these proteins, WNT4 is known to be involved in genital development in fetuses of mammalian species, its role is unknown in avian species. Therefore, in this study, we investigated expression profiles, as well as hormonal and post-transcriptional regulation of WNT4 expression in the reproductive tract of female chickens. Results of this study demonstrated that WNT4 is most abundant in the stromal and luminal epithelial cells of the isthmus and shell gland of the oviduct, respectively. WNT4 is also most abundant in the glandular epithelium of the shell gland of the oviduct of laying hens at 3 h post-ovulation during the laying cycle. In addition, treatment of young chicks with diethylstilbestrol (DES, a synthetic estrogen agonist) stimulated WNT4 only in the glandular epithelial cells of the isthmus and shell gland of the oviduct. Moreover, results of our study demonstrated that miR-1786 influences WNT4 expression via specific binding sites in its 3′-UTR. On the other hand, our results also indicate that WNT4 is expressed predominantly in the glandular epithelium of cancerous ovaries, but not in normal ovaries of hens. Collectively, these results indicate cell-specific expression of WNT4 in the reproductive tract of chickens and that it likely has crucial roles in development and function of oviduct as well as initiation of ovarian carcinogenesis in laying hens.
Regulation of NKG2D signaling during the epithelial-to-mesenchymal transition

The plasma membrane receptor natural killer group 2 member D (NKG2D) underpins a major mechanism whereby natural killer (NK) and T cells recognize malignant cells. We have recently demonstrated that the epithelial-to-mesenchymal transition, one of the first steps of metastatic dissemination, is under the control of an immunological checkpoint that relies on NKG2D-mediated immune responses.
Sensory gating event-related potentials and oscillations in schizophrenia patients and their unaffected relatives.

BACKGROUND The P50 event-related potential sensory gating deficit, a failure to inhibit responses to repeated stimuli, is a leading endophenotype for schizophrenia (SZ). Both gamma and beta event-related oscillations (EROs) are major contributors to the auditory P50 response. However, the topographic distribution of gamma and beta ERO responses to initial (S1) and repeat (S2) stimuli and the association of these oscillations with P50 sensory gating are not clear. METHODS A total of 51 schizophrenic patients, 25 unaffected first-degree relatives, and 34 healthy comparison subjects were tested using a paired-click paradigm. Evoked power of gamma- and beta-band responses using wavelet analyses to S1 and S2 stimuli and gating of EROs and P50 were the main outcome measures. RESULTS A P50 gating deficit was found in patients (P < .001) and at a trend level in relatives (P = .087). Patients showed widely distributed reductions in gamma and beta EROs to S1 stimuli and S2 stimuli, respectively, and impaired gating in both frequencies. Reduced gamma and beta ERO activity in patients was associated primarily with age of onset. Relatives did not differ significantly from control subjects in either EROs power or gating. Gating of P50, gamma, and beta were not significantly correlated (r = .18-.19, P > .05). CONCLUSIONS These results suggest that ERO deficits in gamma to S1 and beta to S2 stimuli and impaired ERO gating are associated with SZ, but are not related to genetic liability for the illness. The components of information processing assessed by gamma- and beta gating appear to be independent from those mediated by P50 suppression.
Fibroblast Growth Factors and their Emerging Cancer-Related Aspects

Fibroblast growth factors (FGF) are proteins that are involved in several biological and developmental processes. Cell proliferation, cell motility, cell survival, and angiogenesis are the fundamental mechanisms that are carried out by these growth factors. FGF ligands when to interact with their receptors-FGFRs, elicit certain signaling pathways that ultimately lead to precise regulated cellular responses. Alterations in FGF/FGFR signaling results in various types of abnormalities. The transition of normal signaling mode of FGFs/FGFRs to an unusual functional pattern causes neurological disorders, skeletal disorders, tumor progression and tumor neovascularization. Overexpression of FGFs and FGFRs has been correlated with advanced tumor forms, mainly prostate, mammary gland, bladder and renal cell carcinomas. These GFs and their receptors are among the fundamental mediators of tumor angiogenesis, others being VEGF, Ang-1, etc. Many pharmaceutical therapies have evolved in the past years to minimize the effects of FGF/FGFR and VEGF signaling, individually as well as simultaneously. Tyrosine kinase inhibitors are the most prominent compounds that have been investigated exclusively in phase I and II clinical trials. However, the applicability of developing therapeutic techniques needs a further illustration better to comprehend the complexity of the underlying mechanism and to provide patients with a better outcome
Lagrangian Stability and Global Optimality in Nonconvex Quadratic Minimization Over Euclidean Balls and Spheres

where A is an n × n real symmetric matrix, b ∈ IRn, r is a positive number. If A is positive semi-definite then (Q1) is a convex quadratic problem. In general (Q1) is nonconvex. Problem (Q2), whose feasible domain is a sphere, is always nonconvex even if A is positive semi-definite. These are among the few nonconvex optimization problems which possess a complete characterization of their optimal solutions. These problems play an important role in optimization and numerical analysis ([1], [4], [8], [9], [11], [12], [16]). Golub et al. studied (Q2) from both theoretical and computational viewpoints. In [3] the sensitivity of the solutions to primal problem was discussed.
The Importance of Psychological Science in a Voter’s Ability to Cast a Vote

Ensuring the integrity of elections is one of the most important elements in maintaining democracy. While it is commonly believed that threats to election integrity are primarily due to security issues, the reality is that voting systems that are not designed to support human perceptual and cognitive limitations also pose a serious and immediate threat. This mismatch between system design and human capabilities can cause tremendous difficulty for voters who are trying to cast a ballot, and has almost certainly altered the outcome of elections in the United States. This article describes the psychological issues that can impact the ability of a voter to cast a vote as intended.
Core or Immersion? Canadian French-Second-Language Teacher Candidates' Perceptions and Experiences of the Best and Worst Program Options for Students with Learning Difficulties and for English Language Learners.

Responding to the needs of and/or including students with different need profiles has been an area of focus within Canadian French Second Language (FSL) education for many years. This study draws on quantitative data from two questionnaires (administered before and after Canadian teacher candidates in FSL education completed their practica) and on qualitative interview data from a volunteer sample of questionnaire participants. The purpose of the study was to explore how these participants viewed the best and worst FSL program options, among four choices, for students who had learning difficulties or who were English language learners, and to see the extent to which these views could be linked to their practicum experience. Though some participants did mention less common programs, most participants restricted their responses to the traditional FSL program dichotomy of core French and French immersion. We noted differences in the participants’ views according to the program of their student teaching practicum and according to the learning need under consideration. Implications for FSL teacher education and FSL education are discussed. In particular, we recommend providing research information to teacher candidates at the Bachelor of Education level in order to encourage teacher candidates to consider evidence as they move toward greater inclusion in FSL; given that these future teachers will need to support varying student needs in their career, this information should be included in their preparation. ISSN 1918-5227 Pages 1737
The transcriptional activator GvpE for the halobacterial gas vesicle genes resembles a basic region leucine-zipper regulatory protein.

The GvpE protein involved in the regulation of gas vesicles synthesis in halophilic archaea has been identified as the transcriptional activator for the promoter located upstream of the gvpA gene encoding the major gas vesicle structural protein GvpA. A closer inspection of the GvpE protein sequence revealed that GvpE resembles basic leucine-zipper proteins typically involved in the gene regulation of eukarya. A molecular modelling study of the C-terminal part implied a cluster of basic amino acid residues constituting the DNA-binding site (DNAB) followed by an amphiphilic helix, suitable for the formation of a leucine-zipper structure within a GvpE dimer. The model of a GvpE dimer docked onto DNA indicated that the side-chains of the basic residues could perfectly interact with the negatively charged phosphate groups of the DNA backbone. Substitution of three basic amino acid residues of this putative DNAB by alanine and/or glutamate generated mutated GvpE proteins. None of these was able to activate the c-gvpA promoter in vivo, indicating that these basic residues are required for GvpE activity. This identification of an archaeal gene regulator displaying similarity to eukaryal regulatory proteins implies that the basic transcription machinery of eukarya and archaea are closely related, and that the regulatory proteins have evolved according to common principles.
Continuous Traffic Flow Dependency Analysis of Urban Periphery Freeway Consecutive Section base on Principle Component Analysis

Urban periphery road network is a special type of roadwork pattern that scatters and distributes around the specific zone of metropolitan and in that contains different grade and functional roads of arterial road, urban freeway and expressway. Urban traffic flow and inter-cities flow transform and divert intensively and massively in this zone also traffic jams and incidents frequently in this zone. Traffic control is necessary and the first basic sector of various different roads should be clearly. In this paper, from the characteristics analysis of continuous traffic flow, utilized the data mining idea and method, the principle component (PCA) was applied to analyzing the dependency of different types of road section that concluded in junction road network. Took Beijing city junction road network as case study, through the analysis of continuous historic data of traffic flow of urban freeway and inter-cities expressway in junction road network, the dependency and their comparison were obtained independently. As a result, the research can benefit reference for macro traffic flow control and guidance.
Reducing the Environmental Impact of Dietary Choice: Perspectives from a Behavioural and Social Change Approach

Climate change is recognised as a significant public health issue that will impact on food security. One of the major contributors to global warming is the livestock industry, and, relative to plant-based agriculture, meat production has a much higher environmental impact in relation to freshwater use, amount of land required, and waste products generated. Promoting increased consumption of plant-based foods is a recommended strategy to reduce human impact on the environment and is also now recognised as a potential strategy to reduce the high rates of some chronic diseases such as cardiovascular disease and certain cancers. Currently there is a scant evidence base for policies and programs aiming to increase consumption of plant-based diets and little research on the necessary conditions for that change to occur and the processes involved in such a change. This paper reviews some of the environmental and health consequences of current dietary practices, reviews literature on the determinants of consuming a plant-based diet, and provides recommendations for further research in this area.
Identifying Geographic Disparities in the Early Detection of Breast Cancer Using a Geographic Information System

Introduction Identifying communities with lower rates of mammography screening is a critical step to providing targeted screening programs; however, population-based data necessary for identifying these geographic areas are limited. This study presents methods to identify geographic disparities in the early detection of breast cancer. Methods Data for all women residing in Dane County, Wisconsin, at the time of their breast cancer diagnosis from 1981 through 2000 (N = 4769) were obtained from the Wisconsin Cancer Reporting System (Wisconsin's tumor registry) by ZIP code of residence. Hierarchical logistic regression models for disease mapping were used to identify geographic differences in the early detection of breast cancer. Results The percentage of breast cancer cases diagnosed in situ (excluding lobular carcinoma in situ) increased from 1.3% in 1981 to 11.9% in 2000. This increase, reflecting increasing mammography use, occurred sooner in Dane County than in Wisconsin as a whole. From 1981 through 1985, the proportion of breast cancer diagnosed in situ in Dane county was universally low (2%–3%). From 1986 through 1990, urban and suburban ZIP codes had significantly higher rates (10%) compared with rural ZIP codes (5%). From 1991 through 1995, mammography screening had increased in rural ZIP codes (7% of breast cancer diagnosed in situ). From 1996 through 2000, mammography use was fairly homogeneous across the entire county (13%–14% of breast cancer diagnosed in situ). Conclusion The percentage of breast cancer cases diagnosed in situ increased in the state and in all areas of Dane County from 1981 through 2000. Visual display of the geographic differences in the early detection of breast cancer demonstrates the diffusion of mammography use across the county over the 20-year period.
Stochastic Service Placement

Resource allocation for cloud services is a complex task due to the diversity of the services and the dynamic workloads. One way to address this is by overprovisioning which results in high cost due to the unutilized resources. A much more economical approach, relying on the stochastic nature of the demand, is to allocate just the right amount of resources and use additional more expensive mechanisms in case of overflow situations where demand exceeds the capacity. In this paper we study this approach and show both by comprehensive analysis for independent normal distributed demands and simulation on synthetic data that it is significantly better than currently deployed methods.
Improving Design Pattern Quality Using Aspect Orientation

Object oriented (OO) implementations of design patterns (DP) may suffer of some problems due to deficiencies of (OO) languages affecting some quality attributes such as modularity, comprehensibility, maintainability and testability. Aspect oriented programming (AOP) provides powerful constructs able to better handle modularity and composition; these constructs can help to overcome some of the trade-offs in current OO implementations of DPs. An approach to re-implement DPs by AOP is presented in this paper: some different AOP re-implementations of DPs in existing systems from real world have been performed to improve DPs quality. A set of existing metrics has been used to evaluate the quality of the different AOP implementations. Such an evaluation helps to select the implementation to use/reuse in a specified context
A New Approach for the Existence Problem of Minimal Cubature Formulas Based on the Larman-Rogers-Seidel Theorem

In this paper we consider the existence problem of minimal cubature formulas of degree $4k+1$ for spherically symmetric integrals. We prove that, for a minimal formula in sufficiently high-dimensional space, there exists some concentric sphere on which the inner product of any two distinct points is rational. By using this result, we prove that for any $d \ge 2$ there exist no $d$-dimensional minimal formulas of degrees $13$ and $21$ for some special integral.
A new cost function to solve RWA Problem in wavelength routed optical network using Genetic Algorithms

Routing and Wavelength Assignment Problem in wavelength division multiplexed optical network is represented as an Integer Linear Program which is found to be NP-Complete. Our attention is devoted to such networks operating under wavelength continuity constraint, in which a lightpath must occupy the same wavelength on all the links it traverses. In setting up a lightpath, a route must be selected and a wavelength must be assigned to the lightpath. We have proposed ILP formulations for MaxRWA and MinRWA problems with a new cost function. The cost function is based on congestion with delay and hop-count is of secondary importance. Genetic Algorithms provide an attractive approach to compute sub-optimal solutions for the RWA problem. This paper discusses a genetic algorithm way of solving the RWA problem on standard networks such as ARPANET.
Color gradients of spiral disks in the Sloan Digital Sky Survey

We investigate the radial color gradients of galactic disks using a sample of ~ 20 000 face-on spiral galaxies selected from the fourth data release of the Sloan Digital Sky Survey (SDSS-DR4). We combine galaxies with similar concentrations, sizes and luminosities to construct composite galaxies, and then measure their color profiles by stacking the azimuthally averaged radial color profiles of all the member galaxies. Except for the smallest galaxies ( R 50 3 kpc), almost all galaxies show negative disk color gradients with mean g − r gradient mag kpc − 1 and r − z gradient mag kpc − 1 . The disk color gradients are independent of the morphological types of galaxies and strongly dependent on the disk surface brightness μ d , with lower surface brightness galactic disks having steeper color gradients.We quantify the intrinsic correlation between color gradients and surface brightness as G gr = − 0 . 011 μ d + 0 . 233 and G rz = − 0 . 015 μ d + 0 . 324 . These quantified correlations provide tight observational constraints on the formation and evolution models of spiral galaxies.
Concevoir avec la Fabrication Additive : Une proposition d’intégration amont de connaissances relatives à une innovation technologique

La Fabrication Additive (FA) vient aujourd’hui bouleverser des habitudes de conception bien ancrees, et suscite dans le meme temps un interet grandissant pour les perspectives qu’elle offre pour l’innovation produit. Pourtant, alors que les enjeux lies a l’innovation sont preponderants en conception amont, peu de concepteurs connaissent et utilisent le potentiel des connaissances FA pour developper puis selectionner des solutions creatives. Dans ce contexte, notre recherche a pour objectif d’augmenter la capacite d’innovation des concepteurs en integrant des connaissances FA lors de la conception amont. Pour cela nous proposons d’integrer des connaissances FA explicites dites « au juste besoin », c’est-a-dire dont le contenu, l'instanciation et le support sont adaptes aux besoins des equipes de conception. De plus, nous proposons que cette integration s’effectue dans un modele de conception permettant l’approche Design With Additive Manufacturing (DWAM). Nos apports sont la proposition : d’une demarche, basee sur le Knowledge Management, permettant de reperer, capitaliser puis valoriser les connaissances FA au juste besoin ; mais egalement d’un modele de conception amont en 3 etapes dans lequel les connaissances FA utiles a l’approche DWAM sont specifiees. Enfin, ce modele enrichi est valorise dans un outil numerique support afin de faciliter le travail collaboratif et concourant.
Design and analysis of security protocol for RFID without back-end database

RFID security protocol is one of the most important ways to solve security problems of RFID system and it is the focus of current research. This article summarized and classified the common security protocols, then proposed a new mutual authentication protocol without the back-end database which aimed at the actual need of military applications and proved the correctness of the new protocol by GNY logic. Safety analysis shows that the new protocol can effectively protect privacy, prevent tracking and avoid synchronization attack and such common problems. The protocol has not only high security, but also the obvious advantage of flexibility.
Anti-Correlation Digital Halftoning

A new class of digital halftoning algorithms is introduced. Anti-correlation digital halftoning (ACDH) combines the idea of a well-known game, Russian roulette, with the statistical approach to bilevel quantization of digital images. A representative of the class, serpentine anticorrelation digital halftoning, is described and compared to error di usion, ordered dither, and other important digital halftoning techniques. Serpentine ACDH causes fewer unpleasant correlated artifacts and less contouring than the benchmark algorithms. The quantization noise spectra associated with serpentine ACDH possess bene cial characteristics related to properties of the vision system. The term \violet noise" is proposed to describe quantization noise with stronger bias in favor of high-frequency components than that of blue noise. Novel techniques for color visualization of the noise spectra and the corresponding phase spectra are introduced, and the relative signi cance of the magnitudes and phases of the discrete Fourier transform of the quantization noise is studied. Unlike popular algorithms based on error di usion, serpentine ACDH does not enhance edges. This is good for applications to digital holography and medical imaging. A simple input preprocessing technique allows one to introduce edge enhancement if desired, while keeping it more isotropic than that of error di usion. The relation between unwanted transient boundary e ects and edge enhancement accompanying error di usion is examined, and approaches to reduction of boundary e ects are considered. Serpentine ACDH does not cause signi cant boundary e ects. The average intensity representation by di erent algorithms is studied for constant input levels (serpentine ACDH does remarkably well). Prospects for ACDH research are discussed.
Simulation of 3D Eddy Current Testing Of Tubes with External Probes: Modelling Approach and Experimental Validations

A popular approach of eddy current testing (ECT) modelling is the volume integral method (VIM) which leads to fast and accurate calculations for canonical geometries. Models developed at CEA using this approach are integrated into the CIVA platform dedicated to non destructive testing (NDT). New configurations have been modelled for the simulation of eddy current inspection of tubes affected by a 3D flaw. Probes concerned here are a set of encircling coils that may be off-centre or tilted with respect to the tube axis and sectorial probes dedicated to eddy current testing of welding seam areas. This paper presents the modelling approach based on volume integral equations and experimental validations carried out at CEA and at Vallourec Research Center (CEV) for these testing configurations.