Miracle-dz/UniFAR-FTUs huggingface dataset:
Decreases in Stomatal Conductance of Soybean under Open-Air Elevation of [CO2] Are Closely Coupled with Decreases in Ecosystem Evapotranspiration12[W][OA]

Stomatal responses to atmospheric change have been well documented through a range of laboratory- and field-based experiments. Increases in atmospheric concentration of CO2 ([CO2]) have been shown to decrease stomatal conductance (gs) for a wide range of species under numerous conditions. Less well understood, however, is the extent to which leaf-level responses translate to changes in ecosystem evapotranspiration (ET). Since many changes at the soil, plant, and canopy microclimate levels may feed back on ET, it is not certain that a decrease in gs will decrease ET in rain-fed crops. To examine the scaling of the effect of elevated [CO2] on gs at the leaf to ecosystem ET, soybean (Glycine max) was grown in field conditions under control (approximately 375 μmol CO2 mol−1 air) and elevated [CO2] (approximately 550 μmol mol−1) using free air CO2 enrichment. ET was determined from the time of canopy closure to crop senescence using a residual energy balance approach over four growing seasons. Elevated [CO2] caused ET to decrease between 9% and 16% depending on year and despite large increases in photosynthesis and seed yield. Ecosystem ET was linked with gs of the upper canopy leaves when averaged across the growing seasons, such that a 10% decrease in gs results in a 8.6% decrease in ET; this relationship was not altered by growth at elevated [CO2]. The findings are consistent with model and historical analyses that suggest that, despite system feedbacks, decreased gs of upper canopy leaves at elevated [CO2] results in decreased transfer of water vapor to the atmosphere.
A risk management process for consumers: the next step in information security

Simply by using information technology, consumers expose themselves to considerable security risks. Because no technical or legal solutions are readily available, and awareness programs have limited impact, the only remedy is to develop a risk management process for consumers. Consumers need to understand the IT risks they face, and decide how to deal with them in an iterative and structured manner: implement technical mitigations, alter their behavior or simply accept the risks. Such a process is feasible: enterprises already execute such processes, and time-saving tools can support the consumer in her own process. In fact, given our society's emphasis on individual responsibilities, skills and devices, a risk management process for consumers is the logical next step in improving information security information security.
HIGH FREQUENCY OSCILLATORY VENTILATION FOR ADULT RESPIRATORY DISTRESS SYNDROME‐A PILOT STUDY

OBJECTIVE To evaluate the safety and effectiveness of high-frequency oscillatory ventilation using a protocol designed to recruit and maintain optimal lung volume in patients with severe adult respiratory distress syndrome (ARDS). SETTING Surgical and medical intensive care units in a tertiary care, military teaching hospital. DESIGN A prospective, clinical study. PATIENTS Seventeen patients, 17 yrs to 83 yrs of age, with severe ARDS (Lung Injury Score of 3.81 +/- 0.23) failing inverse ratio mechanical conventional ventilation (PaO2/FiO2 ratio of 68.6 +/- 21.6, peak inspiratory pressure of 54.3 +/- 12.7 cm H2O, positive end-expiratory pressure of 18.2 +/- 6.9 cm H2O). INTERVENTIONS High-frequency oscillatory ventilation was instituted after varying periods of conventional ventilation (5.12 +/- 4.3 days). We employed lung volume recruitment strategy that consisted of incremental increases in mean airway pressure to achieve a PaO2 of > or = 60 torr (> or = 8.0 kPa), with an FiO2 of < or = 0.6. MEASUREMENTS AND MAIN RESULTS High-frequency oscillator ventilator settings (FiO2, mean airway pressure, pressure amplitude of oscillation [delta P] frequency) and hemodynamic parameters (cardiac output, oxygen delivery [DO2]), mean systemic and pulmonary arterial pressures, and the oxygenation index (oxygenation index = [FiO2 x mean airway pressure x 100]/PaO2) were monitored during the transition to high-frequency oscillatory ventilation and throughout the course of the high-frequency protocol. Thirteen patients demonstrated improved gas exchange and an overall improvement in PaO2/FiO2 ratio (p < .02). Reductions in the oxygenation index (p < .01) and FiO2 (p < .02) at 12, 24, and 48 hrs after starting high-frequency oscillatory ventilation were observed. No significant compromise in cardiac output or DO2 was observed, despite a significant increase in mean airway pressure (31.2 +/- 10.3 to 34.0 +/- 6.7 cm H2O, p < .05) on high-frequency oscillatory ventilation. The overall survival rate at 30 days was 47%. A greater number of pretreatment days on conventional ventilation (p < .009) and an entry oxygenation index of > 47 (sensitivity 100%, specificity 100%) were associated with mortality. CONCLUSIONS High-frequency oscillatory ventilation is both safe and effective in adult patients with severe ARDS failing conventional ventilation. A lung volume recruitment strategy during high-frequency oscillatory ventilation produced improved gas exchange without a compromise in DO2. These results are encouraging and support the need for a prospective, randomized trial of algorithm-controlled conventional ventilation vs. high-frequency oscillatory ventilation for adults with severe ARDS.
No More Déjà Vu—Eliminating Redundancy With CacheCast: Feasibility and Performance Gains

Due to the lack of multicast services in the Internet, applications based on single-source, multiple-destination transfers such as video conferencing, IP radio, and IPTV must use unicast. This type of traffic exhibits high redundancy with temporal clustering of duplicated packets. The redundancy originates from multiple transfers of the same data chunk over the same link. We propose CacheCast, a link-layer caching mechanism that eliminates the redundant data transmissions using small caches on links. CacheCast's underlying principles are simplicity and reliability. It is a fully distributed and incrementally deployable architecture. It consists of small caches on links that act independently and a server support that simplifies the link cache operation. Our analysis indicates that transfers of the same data to multiple destinations with CacheCast can achieve near-multicast efficiency in terms of consumed link bandwidth. The implementation of CacheCast proves its feasibility, efficiency, and the improvements of the server.
Linguistic foundations for bidirectional transformations: invited tutorial

Computing is full of situations where two different structures must be "connected" in such a way that updates to each can be propagated to the other. This is a generalization of the classical view update problem, which has been studied for decades in the database community [11, 2, 22]; more recently, related problems have attracted considerable interest in other areas, including programming languages [42, 28, 34, 39, 4, 7, 33, 16, 1, 37, 35, 47, 49] software model transformation [43, 50, 44, 45, 12, 13, 14, 24, 25, 10, 51], user interfaces [38] and system configuration [36]. See [18, 17, 10, 30] for recent surveys. Among the fruits of this cross-pollination has been the development of a linguistic perspective on the problem. Rather than taking some view definition language as fixed (e.g., choosing some subset of relational algebra) and looking for tractable ways of "inverting" view definitions to propagate updates from view to source [9], we can directly design new bidirectional programming languages in which every expression defines a pair of functions mapping updates on one structure to updates on the other. Such structures are often called lenses [18]. The foundational theory of lenses has been studied extensively [20, 47, 26, 32, 48, 40, 15, 31, 46, 41, 21, 27], and lens-based language designs have been developed in several domains, including strings [5, 19, 3, 36], trees [18, 28, 39, 35, 29], relations [6], graphs [23], and software models [43, 50, 44, 12, 13, 14, 24, 25, 8]. These languages share some common elements with modern functional languages---in particular, they come with very expressive type systems. In other respects, they are rather novel and surprising. This tutorial surveys recent developments in the theory of lenses and the practice of bidirectional programming languages.
Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic.

CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have been no direct measurements of KSHV prevalence at the beginning of the HIV epidemic. OBJECTIVES To determine the prevalence of KSHV infection in homosexual men in San Francisco, Calif, at the beginning of the HIV epidemic in 1978 and 1979 and to examine changes in prevalence of KSHV at time points from 1978 through 1996 in light of changes in sexual behavior. DESIGN, SETTING, AND PARTICIPANTS Analysis of a clinic-based sample (n = 398) derived from the San Francisco City Clinic Cohort (ages 18-66 years) (n = 2666 for analyses herein) and from population-based samples from the San Francisco Men's Health Study (MHS) (ages 25-54 years) (n = 825 and 252) and the San Francisco Young Men's Health Study (YMHS) (ages 18-29 years) (n = 428-976, and 557); behavioral studies were longitudinal and KSHV prevalence studies were cross-sectional. MAIN OUTCOME MEASURES Antibodies against KSHV and HIV; sexual behaviors. RESULTS The prevalence of KSHV infection in 1978 and 1979 was 26.5% of 235 (a random sample) overall (weighted for HIV infection) vs 6.9% (128/1842) for HIV in the San Francisco City Clinic Cohort sample. The prevalence of KSHV infection remained essentially unchanged between an MHS sample of 252 in 1984 and 1985 (29.6%) and a YMHS sample of 557 in 1995 and 1996 (26.4%), while HIV prevalence dropped from 49.5% of 825 in 1984 and 1985 (MHS) to 17.6% of 428 in 1992 and 1993 (YMHS). The proportion of men practicing unprotected receptive anal intercourse with 1 or more partners declined from 54% to 11% during the 1984 through 1993 period (MHS) with similar though slightly higher values in the YMHS in 1992 and 1993; whereas for unprotected oral intercourse it ranged between 60% and 90% in the 1984 through 1996 period (MHS and YMHS). CONCLUSIONS Infection with KSHV was already highly prevalent in homosexual men when the HIV epidemic began in San Francisco, and its prevalence has been maintained at a nearly constant level. Any declines in the incidence of Kaposi sarcoma do not appear to be caused by a decline in KSHV transmission.
A measurement study of tracking in paid mobile applications

Smartphone usage is tightly coupled with the use of apps that can be either free or paid. Numerous studies have investigated the tracking libraries associated with free apps. Only a limited number of these have focused on paid apps. As expected, these investigations indicate that tracking is happening to a lesser extent in paid apps, yet there is no conclusive evidence. This paper provides the first large-scale study of paid apps. We analyse top paid apps obtained from four different countries: Australia, Brazil, Germany, and US, and quantify the level of tracking taking place in paid apps in comparison to free apps. Our analysis shows that 60% of the paid apps are connected to trackers that collect personal information compared to 85%--95% in free apps. We further show that approximately 20% of the paid apps are connected to more than three trackers. With tracking being pervasive in both free and paid apps, we then quantify the aggregated privacy leakages associated with individual users. Using the data of user installed apps of over 300 smartphone users, we show that 50% of the users are exposed to more than 25 trackers which can result in significant leakages of privacy.
Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

Background Bronchiolisation of distal airspaces is an unexplained feature of idiopathic pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. Immunostaining for components of those pathways and mucins were performed on lung tissue obtained from patients with IPF (n=20), chronic obstructive pulmonary disease (n=13), idiopathic pulmonary artery hypertension (n=5) and from organ donors (n=6). NRG1α and NRG1β were quantified in bronchoalveolar lavage fluid (BALF) of patients with early IPF (n=20), controls (n=9), and patients with other interstitial pneumonias (n=13). Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. IPF mucus cells expressed MUC5B but low levels of MUC5AC and MUC2, a profile typical of submucosal glands. Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. The Notch target, HES1, was present in mucus cells from all groups. NRG1α was detected in serous cells within normal submucosal glands and in epithelial cells lining honeycombing areas in IPF, and was not detected in other patients. NRG1α concentrations were elevated in BALF from patients with early IPF. Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. NRG1α may contribute to bronchiolisation of the distal lung seen in IPF.
Analysis on Target Detection and Classification in LTE Based Passive Forward Scattering Radar

The passive bistatic radar (PBR) system can utilize the illuminator of opportunity to enhance radar capability. By utilizing the forward scattering technique and procedure into the specific mode of PBR can provide an improvement in target detection and classification. The system is known as passive Forward Scattering Radar (FSR). The passive FSR system can exploit the peculiar advantage of the enhancement in forward scatter radar cross section (FSRCS) for target detection. Thus, the aim of this paper is to show the feasibility of passive FSR for moving target detection and classification by experimental analysis and results. The signal source is coming from the latest technology of 4G Long-Term Evolution (LTE) base station. A detailed explanation on the passive FSR receiver circuit, the detection scheme and the classification algorithm are given. In addition, the proposed passive FSR circuit employs the self-mixing technique at the receiver; hence the synchronization signal from the transmitter is not required. The experimental results confirm the passive FSR system’s capability for ground target detection and classification. Furthermore, this paper illustrates the first classification result in the passive FSR system. The great potential in the passive FSR system provides a new research area in passive radar that can be used for diverse remote monitoring applications.
Extruded and Spheronized Beads Containing No Microcrystalline Cellulose: Influence of Formulation and Process Variables

The purposes of this study were to investigate the use of chitosan in the manufacture of beads by extrusion‐spheronization without inclusion of microcrystalline cellulose, and to study the effect of formulation and process variables on the characteristics of the beads. Beads containing chitosan, fine particle ethylcellulose, hydroxypropyl methylcellulose (HPMC), and caffeine as the model drug were manufactured. Bead size, yield, shape, friability, density, porosity, and release studies were determined. Spherical beads with good mechanical properties could be manufactured without microcrystalline cellulose. Release studies showed that there was immediate release of drug from the beads. A five factor, half fraction screening design was employed to study the effect of formulation variables and process variables on the properties of the beads. Statistical analysis indicated that formulation variables such as the chitosan content, HPMC content, and water content, and process variables such as the spheronizer speed and extruder speed significantly affected the physical properties of the beads. The bead size decreased with an increase in chitosan content. Significant two‐factor interactions exist between the variables for several of the measured responses. Beads with high percentage yield and high sphericity can be obtained at high chitosan content, and low HPMC content, water content, spheronizer speed, and extruder speed. Less friable beads can be obtained at high levels of studied formulation variables and low levels of studied process variables. Beads of high density and low porosity can be manufactured at high levels of the studied formulation and process variables. Regression equations were generated using Statgraphics Plus software that can be used to develop formulations with desired bead properties. Chitosan was useful to provide beads of acceptable physical properties using water as a granulating fluid in the extrusion‐spheronization process.
BoSCC: Bag of Spatial Context Correlations for Spatially Enhanced 3D Shape Representation

Highly discriminative 3D shape representations can be formed by encoding the spatial relationship among virtual words into the Bag of Words (BoW) method. To achieve this challenging task, several unresolved issues in the encoding procedure must be overcome for 3D shapes, including: 1) arbitrary mesh resolution; 2) irregular vertex topology; 3) orientation ambiguity on the 3D surface; and 4) invariance to rigid and non-rigid shape transformations. In this paper, a novel spatially enhanced 3D shape representation called bag of spatial context correlations (BoSCCs) is proposed to address all these issues. Adopting a novel local perspective, BoSCC is able to describe a 3D shape by an occurrence frequency histogram of spatial context correlation patterns, which makes BoSCC become more compact and discriminative than previous global perspective-based methods. Specifically, the spatial context correlation is proposed to simultaneously encode the geometric and spatial information of a 3D local region by the correlation among spatial contexts of vertices in that region, which effectively resolves the aforementioned issues. The spatial context of each vertex is modeled by Markov chains in a multi-scale manner, which thoroughly captures the spatial relationship by the transition probabilities of intra-virtual words and the ones of inter-virtual words. The high discriminability and compactness of BoSCC are effective for classification and retrieval, especially in the scenarios of limited samples and partial shape retrieval. Experimental results show that BoSCC outperforms the state-of-the-art spatially enhanced BoW methods in three common applications: global shape retrieval, shape classification, and partial shape retrieval.
Milestones in Time: The Value of Landmarks in Retrieving Information from Personal Stores

We describe the design and analysis of timeline visualizations for displaying the results of queries on an index of personal content. The visualization was built on top of a personal search engine that provides a unified index of all the information a user has seen, including web pages, email, and documents. Results of searches are presented with an overview-plus-detail timeline visualization. A summary view shows the distribution of search hits over time, and a detailed view allows for inspection of individual search results. In a user study, we explore the value of extending a basic time view by adding public landmarks (holidays and important news events) and personal landmarks (photos and important calendar events).
Sex Differences in Major Bleeding With Glycoprotein IIb/IIIa Inhibitors: Results From the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) Initiative

Background— Glycoprotein (GP) IIb/IIIa inhibitors are beneficial in patients with non–ST-segment elevation acute coronary syndromes (NSTE ACS); their safe use in women, however, remains a concern. The contribution of dosing to the observed sex-related differences in bleeding is unknown. Methods and Results— We explored the relationship between patient sex, GP IIb/IIIa inhibitor use, dose, and bleeding in 32 601 patients with NSTE ACS across 400 CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) hospitals, of whom 18 436 were treated. GP IIb/IIIa inhibitor dose was defined as excessive if not reduced when creatinine clearance was <50 mL/min for eptifibatide or <30 mL/min for tirofiban. Major bleeding was defined as a hematocrit drop ≥0.12, need for transfusion, or intracranial bleeding. Major bleeding was adjusted for clinical factors and antithrombotic dose. The risk for bleeding attributable to excess GP IIb/IIIa dose was determined by sex using prevalence and adjusted odds ratios (ORs). Women had higher rates of major bleeding than men among those treated with GP IIb/IIIa inhibitors (15.7% versus 7.3%, P<0.0001) and among those not treated (8.5% versus 5.4%, P<0.0001). Despite similar serum creatinine levels, creatinine clearance averaged 20 points lower among treated women than men. Treated women were also more likely to receive excess GP IIb/IIIa doses than men (46.4% versus 17.2%, P<0.0001; adjusted OR 3.81, 95% confidence interval [CI] 3.39 to 4.27). Excess dosing was associated with increased risk of bleeding in women (OR 1.72, 95% CI 1.30 to 2.28) and men (OR 1.27, 95% CI 0.97 to 1.66); however, bleeding risk attributable to dosing was much higher in women (25.0% versus 4.4%). Conclusions— Women experience more bleeding than men whether or not they are treated with GP IIb/IIIa inhibitors; however, because of frequent excessive dosing in women, up to one fourth of this sex-related risk difference in bleeding is avoidable. Appropriate dosing will improve care of all patients with NSTE ACS, with a particular benefit for women.
An Improved Ant Colony Clustering Algorithm Based on LF Algorithm

Aiming at the deficiencies of ant colony clustering algorithms in distance measure, convergence rate, similarity clustering, and other aspects, WALF algorithm is presented as an improvement to the LF algorithm. Using weighted hybrid distance as distance measure, and introducing the adaptive mechanism during the process of clustering, ant colonies can adjust the radius of neighborhoods dynamically and merge similar clusters in the process, meeting the clustering requirements while improving the convergence speed. Finally WALF algorithm has been shown through experiments to be better than LF algorithm both in clustering results and efficiency.
Identification of Anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig™) Proteins with Unique Activities

Inhibiting ErbB2 signaling with monoclonal antibodies (mAbs) or small molecules is an established therapeutic strategy in oncology. We have developed anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig) proteins that capture the function of a combination of two anti-ErbB2 antibodies. In addition, some of the anti-ErbB2 DVD-Ig proteins gain the new functions of enhancing ErbB2 signaling and cell proliferation in N87 cells. We further found that two DVD-Ig proteins, DVD687 and DVD688, have two distinct mechanisms of actions in Calu-3 and N87 cells. DVD687 enhances cell cycle progression while DVD688 induces apoptosis in N87 cells. Using a half DVD687, we found that avidity may play a key role in the agonist activity of DVD687 in N87 cells.