Miracle-dz/UniFAR-FTUs huggingface dataset:
An Online Dynamic Cable Rating System for an Industrial Power Plant in the Restructured Electric Market

In addition to market information, available energy and capacity to participate in the market are also essential to be an effective market participant. This paper discusses the development of an online dynamic cable rating system (DCRS) that can help a system engineer maximize asset utilization without jeopardizing system facilities or compromising the reliability of the cables. Based on real-time cable loading, cable surface temperature, ambient temperature, and forecasting temperature, the DCRS can estimate both steady-state and dynamic cable rating. To confirm with the actual operation condition, both real-time cable temperature and forecasting ambient temperature are taken into consideration to perform short-term cable ampacity estimation to prevent overestimation and/or underestimation. Based on the information provided by the DCRS, the system engineer can establish or adjust the bidding strategy in time to effectively participate in the restructured electric markets.
String Theory and the Shape of the Universe

Much effort has been expended recently on attempts to determine the topology of the Universe by means of direct astronomical evidence. However, little is known about how theory, in particular, string theory, constrains cosmic topology. Here we show that if our world is a de Sitter-like brane-world in an anti-de Sitter background -- an assumption which corresponds to one of the proposed ways of reconciling an accelerating universe with string theory -- then there is a conflict with the "dodecahedral" cosmology proposed recently. The argument is based on the Adams-Polchinski-Silverstein conjecture, evidence for which has recently been accumulating.
İstismarcı Yönetici Algısının Kaytarma Üzerindeki Etkisinde Duygusal Tükenmenin Aracılık Rolü: Otel İşletmelerinde Bir İnceleme

Bu calismada, istismarci yonetici algisinin, kaytarma uzerindeki dogrudan etkisi ve duygusal tukenmenin, istismarci yonetici algisi ile kaytarma iliskisi uzerindeki araci etkisi incelenmistir. Bu kapsamda, Antalya iline bagli Side-Manavgat ve Alanya bolgesinde faaliyet gosteren 13 otel isletmesinin (dort adet bes yildizli, yedi adet dort yildizli ve iki adet uc yildizli) on buro, kat hizmetleri ve yiyecek icecek departmanlarinda calisan 269 katilimcidan elde edilen veriler analize dâhil edilmistir. Kolayda ornekleme yonteminin tercih edildigi calismada verilerin analizinde, SPSS 16 ve Lisrel 8.51 paket programlarindan yararlanilmistir. Calisma sonucunda duygusal tukenmenin, istismarci yonetici algisi ile kaytarma iliskisinde kismi araci bir rolunun oldugu ortaya cikmistir.
Lean production and agile organizaton : the link between supply chain and sustainable development

While there could be separate streams of established research on lean production, agile organization and sustainable supply chain, the idea is to address the intersection of these strategic initiatives in order to find synergies and competitive advantage for companies. The goal of this mission is to explore the link between supply chains and sustainable development with the insights of the two main paradigms in the changing competitive environment : lean and agility. On the one side, the focus of the lean approach has essentially been on the elimination of waste and all non value activities. On the other side, a key characteristic of an agile organization is flexibility at different echelon. The concern is to analyze how companies could manage the lean and agility principles in the supply chain with sustainable development at the different stage of the supply chain.
Early Life Nutrition, Epigenetics and Programming of Later Life Disease

The global pandemic of obesity and type 2 diabetes is often causally linked to marked changes in diet and lifestyle; namely marked increases in dietary intakes of high energy diets and concomitant reductions in physical activity levels. However, less attention has been paid to the role of developmental plasticity and alterations in phenotypic outcomes resulting from altered environmental conditions during the early life period. Human and experimental animal studies have highlighted the link between alterations in the early life environment and increased risk of obesity and metabolic disorders in later life. This link is conceptualised as the developmental programming hypothesis whereby environmental influences during critical periods of developmental plasticity can elicit lifelong effects on the health and well-being of the offspring. In particular, the nutritional environment in which the fetus or infant develops influences the risk of metabolic disorders in offspring. The late onset of such diseases in response to earlier transient experiences has led to the suggestion that developmental programming may have an epigenetic component, as epigenetic marks such as DNA methylation or histone tail modifications could provide a persistent memory of earlier nutritional states. Moreover, evidence exists, at least from animal models, that such epigenetic programming should be viewed as a transgenerational phenomenon. However, the mechanisms by which early environmental insults can have long-term effects on offspring are relatively unclear. Thus far, these mechanisms include permanent structural changes to the organ caused by suboptimal levels of an important factor during a critical developmental period, changes in gene expression caused by epigenetic modifications (including DNA methylation, histone modification, and microRNA) and permanent changes in cellular ageing. A better understanding of the epigenetic basis of developmental programming and how these effects may be transmitted across generations is essential for the implementation of initiatives aimed at curbing the current obesity and diabetes crisis.
Clinical Significance of Cerebral Microbleeds Locations in CADASIL with R544C NOTCH3 Mutation

Background and Purpose Although cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common single-gene disorder of cerebral small blood vessels caused by NOTCH3 mutations, little has been described about the variation in the clinical findings between its underlying types of mutations. In particular, the presence of cerebral microbleeds (CMBs) has been an increasingly recognized magnetic resonance imaging finding in CADASIL, but their clinical significance is not clear. The purpose of this study is to assess whether CMBs are associated with symptomatic stroke in the CADASIL patients with R544C mutation and to compare the cerebral distribution of CMBs between CADASIL patients with and without symptomatic stroke. Methods This is a cohort study of patients who were diagnosed with genotype-confirmed R544C-mutation CADASIL. Primary neurologic symptoms were recorded. Symptomatic strokes were defined as transient ischemic attack, ischemic strokes and hemorrhagic strokes. CMBs were defined as focal areas of round signal loss on T2*-weighted gradient echo planar images with a diameter of less than 10 mm. The locations of CMBs were divided into lobar, basal ganglia, thalamus, brain stem and cerebellum. Multiple logistic regressions were performed to identify the epidemiologic or vascular risk factors associated with symptomatic stroke in patients with CADASIL. Results Among total of 51 subjects in this cohort, CMBs were present in 20 of 32 patients (64.5%) in the symptomatic stroke-group and in 8 of 19 patients (42.1%) in the non-stroke group (p = 0.16). CMBs were observed more frequently in the basal ganglia (p<0.001) and the cerebellum (p<0.018) in the symptomatic stoke group compared to the non-stroke group. The mean number of CMBs was significantly higher in the symptomatic stroke group (15.4±18.0 lesions per patients with CMBs) versus those without symptomatic stroke (3.3±3.0 lesions per patients with CMBs) (p = 0.003). Hypertension was an independent risk factor for symptomatic stroke in CADASIL (p = 0.014). It was independently associated with CMBs locations as basal ganglia (p = 0.016), thalamus (p = 0.010), brainstem (p = 0.044), and cerebellum (p = 0.049). However, It was not independently associated with CMBs on lobar lesion (p = 0.152). Conclusions In this study hypertension was an independent predictor of CMBs presence in specific brain locations, as well as symptomatic stroke in the CADASIL patients. The distribution and burden of CMBs might be a clinically useful marker for the risk of symptomatic stroke. However, further prospective studies on the relationship between CMBs distribution and symptomatic stroke are required in order to support these preliminary findings.
Syntaxin 1B, but Not Syntaxin 1A, Is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses

Two syntaxin 1 (STX1) isoforms, HPC-1/STX1A and STX1B, are coexpressed in neurons and function as neuronal target membrane (t)-SNAREs. However, little is known about their functional differences in synaptic transmission. STX1A null mutant mice develop normally and do not show abnormalities in fast synaptic transmission, but monoaminergic transmissions are impaired. In the present study, we found that STX1B null mutant mice died within 2 weeks of birth. To examine functional differences between STX1A and 1B, we analyzed the presynaptic properties of glutamatergic and GABAergic synapses in STX1B null mutant and STX1A/1B double null mutant mice. We found that the frequency of spontaneous quantal release was lower and the paired-pulse ratio of evoked postsynaptic currents was significantly greater in glutamatergic and GABAergic synapses of STX1B null neurons. Deletion of STX1B also accelerated synaptic vesicle turnover in glutamatergic synapses and decreased the size of the readily releasable pool in glutamatergic and GABAergic synapses. Moreover, STX1A/1B double null neurons showed reduced and asynchronous evoked synaptic vesicle release in glutamatergic and GABAergic synapses. Our results suggest that although STX1A and 1B share a basic function as neuronal t-SNAREs, STX1B but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
Change analysis of dynamic copula for measuring dependence in multivariate ﬁnancial data

This paper proposes a new approach to measure the dependence in multivariate ﬁnancial data. Data in ﬁnance and insurance often cover a long time period. Therefore, the economic factors may induce some changes inside the dependence structure. Recently, two methods using copulas have been proposed to analyze such changes. The ﬁrst approach investigates the changes of copula’s parameters. The second one tests the changes of copulas by determining the best copulas using moving windows. In this paper we take into account the non stationarity of the data and analyze: (1) the changes of parameters while the copula family keeps static; (2) the changes of copula family. We propose a series of tests based on conditional copulas and goodness-of-ﬁt (GOF) tests to decide the type of change, and further give the corresponding change analysis. We illustrate our approach with Standard & Poor 500 and Nasdaq indices, and provide dynamic risk measures.
A New Generalized Approach to Application-Defined Scheduling

In previous papers we had presented an application program interface (API) that enabled applications to use application-defined scheduling algorithms in a way compatible with the scheduling model defined in POSIX. This paper presents a new more general API with three main enhancements. First, the application scheduler is described as an abstract object that needs not be implemented as a thread, thus potentially increasing efficiency in some operating system architectures. Second, we define an abstract notion of urgency that is used by the kernel to order the threads in the scheduling queue, freeing the application scheduler of the responsibility of keeping the desired ordering of threads, and thus simplifying it and reducing overhead. In third place, we also consider thread synchronization through mutexes by adding the Stack Resource Policy or the Priority Inheritance Policy adapted to the generalized concept of urgency, both of which can be used in a large variety of fixed and dynamic priority scheduling policies without explicit intervention of the application scheduler.
My online teacher 2.0

This paper describes a new design of MOT, My Online Teacher, an authoring system for adaptive delivery of content, called MOT 2.0. The new design focuses on collaborative authoring and social annotation between communities of authors, as well as applying adaptivity based on users’ activities. The MOT 2.0 observes authors’ interaction patterns and suggests recommended/related materials and can recommend collaborators. Furthermore, it enables adaptive collaboration support by harnessing Web 2.0 and its characteristics (i.e., tagging, voting, commenting, and user-generated content), thus, allowing for group-based adaptation. In this way, MOT 2.0 combines the strength of Web 2.0 authoring with adaptive hypermedia –based authoring for personalization. Therefore, the paper answers the question of how to harness the strengths of Web 2.0 to provide group based adaptation for the authoring process.
Redundant trees for preplanned recovery in arbitrary vertex-redundant or edge-redundant graphs

We present a new algorithm which creates redundant trees on arbitrary node-redundant or link-redundant networks. These trees are such that any node is connected to the common root of the trees by at least one of the trees in case of node or link failure. Our scheme provides rapid preplanned recovery of communications with great flexibility in the topology design. Unlike previous algorithms, our algorithm can establish two redundant trees in the case of a node failing in the network. In the case of failure of a communications link, our algorithm provides a superset of the previously known trees.
Should Stroke Trials Adjust Functional Outcome for Baseline Prognostic Factors ?

Background and Purpose—Many stroke trials have provided neutral results. Suboptimal statistical analyses may be failing to detect effective interventions. Adjusting outcomes for baseline prognostic factors in the analysis may improve the efficiency of analysis of outcomes. Methods—Data from 23 stroke trials (25 674 patients) assessing functional outcome were included. The prognostic variables considered were age, sex, and baseline severity. Unadjusted and adjusted ordinal logistic regression models were compared using simulated data from each trial (10 000 simulations per trial). Three levels of treatment effect were assessed with ORs of 0.95, 0.74, and 0.57. The reduction in sample size gained from using the adjusted models, as compared with an unadjusted model, was then calculated as a reflection of the increase in statistical power. Results—Adjusting outcome for baseline factors led to a reduction in sample size, which was similar across all 3 treatment effects (median percentage reduction, interquartile range): OR 0.95: 35.3% (21.0 to 42.1); OR 0.74: 38.4% (29.4 to 42.7); and OR 0.57: 38.4% (27.4 to 42.2). As the treatment effect increased, the proportion of simulations in which the treatment effect for the adjusted model was greater than for the unadjusted model also increased. Conclusion—Adjusting for prognostic factors in stroke trials can reduce sample size by at least 20% to 30% (the lower interquartile range) for a given power. Conversely, trialists may want to power for an unadjusted analysis and then increase statistical power by adjusting for prognostic factors. (Stroke. 2009;40:888-894.)
Biomechanical correlates of club-head velocity during the golf swing

Golfers are able to attain a competitive advantage when they are able to achieve long hitting distances from the tee. Club-head velocity is perhaps the most commonly reported kinematic variable in the golfing scientific literature. This study aimed to identify 3-D kinematic aspects of the golf swing linked to the generation of club-head velocity using regression analyses. Maximal golf swings were obtained from fifty golfers using an eight camera motion capture system operating at 500 Hz. Full body three-dimensional kinematics were obtained. Multiple regression modelling was used to identify the discrete 3-D kinematic parameters associated with the development of club-head velocity. Two biomechanical parameters; sagittal plane wrist velocity and peak transverse plane torso rotation (Adj R2=0.58, p≤0.01) were obtained as significant predictors of club-head velocity. The findings from this study therefore suggest these parameters are the strongest contributors to ball velocity and potentially overall driving performance. It is conceivable based on these observations, that golfers may benefit from exposure to coaching and conditioning techniques geared towards the improvement of these parameters in order to improve their driving distance.
Domain of Dentine Sialoprotein Mediates Proliferation and Differentiation of Human Periodontal Ligament Stem Cells

Classic embryological studies have documented the inductive role of root dentin on adjacent periodontal ligament differentiation. The biochemical composition of root dentin includes collagens and cleavage products of dentin sialophosphoprotein (DSPP), such as dentin sialoprotein (DSP). The high abundance of DSP in root dentin prompted us to ask the question whether DSP or peptides derived thereof would serve as potent biological matrix components to induce periodontal progenitors to further differentiate into periodontal ligament cells. Here, we test the hypothesis that domain of DSP influences cell fate. In situ hybridization and immunohistochemical analyses showed that the COOH-terminal DSP domain is expressed in mouse periodontium at various stages of root development. The recombinant COOH-terminal DSP fragment (rC-DSP) enhanced attachment and migration of human periodontal ligament stem cells (PDLSC), human primary PDL cells without cell toxicity. rC-DSP induced PDLSC cell proliferation as well as differentiation and mineralization of PDLSC and PDL cells by formation of mineralized tissue and ALPase activity. Effect of rC-DSP on cell proliferation and differentiation was to promote gene expression of tooth/bone-relate markers, transcription factors and growth factors. The results for the first time showed that rC-DSP may be one of the components of cell niche for stimulating stem/progenitor cell proliferation and differentiation and a natural scaffold for periodontal regeneration application.
The Current and Future Status of the Concealed Information Test for Field Use

The Concealed Information Test (CIT) is a psychophysiological technique for examining whether a person has knowledge of crime-relevant information. Many laboratory studies have shown that the CIT has good scientific validity. However, the CIT has seldom been used for actual criminal investigations. One successful exception is its use by the Japanese police. In Japan, the CIT has been widely used for criminal investigations, although its probative force in court is not strong. In this paper, we first review the current use of the field CIT in Japan. Then, we discuss two possible approaches to increase its probative force: sophisticated statistical judgment methods and combining new psychophysiological measures with classic autonomic measures. On the basis of these considerations, we propose several suggestions for future practice and research involving the field CIT.
An elective radiation dose of 46 Gy is feasible in nasopharyngeal carcinoma treated by intensity-modulated radiotherapy

Abstract The purpose of this study is to compare the treatment outcome of different radiation doses of elective neck irradiation (ENI) in nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT). In total, 504 patients with nondisseminated NPC who underwent magnetic resonance imaging before radical IMRT between 2000 and 2008 were retrospectively reviewed. The patients were classified into 2 groups based on the ENI dose: low ENI when the ENI dose was 46 Gy (n = 446) and high ENI when the ENI doses were 50 to 60 Gy (n = 58). All the patients in both the groups received a median dose of 72 Gy to the gross tumor and involved nodes. The fraction size was 2 Gy per fraction. Matching was performed between low ENI and high ENI in a 2:1 ratio, and the matching criteria were N-stage, T-stage, treatment modality, pathology classification, sex, and age. The median follow-up for all patients was 63.5 months. In all patients, the 5-year progression-free survival (PFS), local control (LC), regional control (RC), distant metastasis-free survival (DMFS), overall survival (OS), and cancer-specific survival (CSS) for low ENI and high ENI patients were 69.0% and 63.2% (P = 0.331), 89.0% and 83.9% (P = 0.235), 90.1% and 85.2% (P = 0.246), 86.8% and 76.6% (P = 0.056), 77.5% and 80.8% (P = 0.926), and 84.4% and 82.5% (P = 0.237), respectively. In the matched-pair analysis, the 5-year PFS, LC, RC, DMFS, OS, and CSS for matched low ENI and high ENI patients were 74.1% and 63.2% (P = 0.134), 92.0% and 83.9% (P = 0.152), 90.1% and 85.2% (P = 0.356), 86.2% and 76.6% (P = 0.125), 87.0% and 80.8% (P = 0.102), and 88.6% and 82.5% (P = 0.080), respectively. In the multivariable analysis for all patients, the ENI group was not a significant factor for PFS, LC, RC, DMFS, OS, and CSS. A low ENI dose of 46 Gy in 23 fractions is feasible in NPC patients treated with IMRT, and this concept should be validated in the prospective studies.
Non-contact tactile sensation synthesized by ultrasound transducers

This paper describes a new tactile device which produces stress fields in 3D space. Combined with mid-air and/or 3D stereoscopic displays, this device provides high-fidelity tactile feedback for interaction with visual objects. The principle is based on a nonlinear phenomenon of ultrasound; acoustic radiation pressure. The fabricated prototype device consists of 324 airborne ultrasound transducers, and the phase and intensity of each transducer are controlled individually. The total output force within the focal region is 1.6 gf. The spatial resolution is 20 mm. The prototype can produce sufficient vibrations up to 1 kHz. An interaction system including the prototype is also introduced which tracks user's hand and provides suitable touch feeling.
Performance of an optimal receiver in the presence of alpha-stable and Gaussian noises

This paper deals with the optimal (in the maximum likelihood sense) detection performance of binary transmission in a mixture of a Gaussian noise and an impulsive interference modeled as an alpha-stable process. The main contribution is in the Monte Carlo simulation that shows that the Gaussianity assumption for the test statistic as reported in earlier works is not valid unless a very large number of repetitions is used.
A design architecture for OSEK/VDX-based vehicular application specific embedded operating systems

The open vehicular industry standard OSEK/VDX is introduced briefly and an OSEK/VDX-based architecture for vehicular application specific embedded operating systems are proposed in this paper. This architecture is designed based on a microkernel mode since its flexibility, reliability and portability are critical to the safety and performance of vehicles. Finally, the UML is used to model the architecture of vehicular application specific embedded operating systems. Through analyzing the functions and the proposed relationships among different components, the feasibility of constructing a Linux-based vehicular application specific embedded operating system is demonstrated.