Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of the Digene HPV Genotyping LQ Test and the PANArray HPV Genotyping Chip for Detection of High-Risk or Probable High-Risk Human Papillomavirus Genotypes

Background We evaluated the performance of two different array-based techniques, a bead-based multiplex genotyping method (LQ; digene HPV Genotyping LQ Test, QIAGEN, Germany) and a DNA chip-based method using peptide nucleic acid probes (PANArray; PANArray HPV Genotyping Chip, Panagene, Korea), for detection of human papillomavirus (HPV) and genotyping of high-risk (HR) or probable high-risk (PHR) HPVs in healthy patients who visited a health-promotion center. Methods We obtained 508 unselected, consecutive cervicovaginal swab specimens. All specimens were examined by using the PANArray and LQ tests. All HPV-positive samples were then analyzed by multiplex PCR and direct sequencing. Results The LQ test detected 47 HPV-positive cases (9.3%) with HR or PHR genotypes and the PANArray test identified 36 cases (7.1%). When the results of LQ and PANArray were compared by using comprehensive genotyping (integrated interpretation of the results of LQ, PANArray, multiplex PCR, and direct sequencing) for the detection of HR or PHR genotypes, the kappa values were 0.44 and 0.30 for LQ and PANArray, respectively. In comparison to comprehensive genotyping, the LQ test yielded 53 (60.0%) concordant and 12 (13.5%) compatible results, and the PANArray yielded 36 (40.4%) concordant and three (3.4%) compatible results. Conclusions The results of the LQ test had higher concordance and/or greater compatibility with those of comprehensive genotyping for the detection of HR or PHR genotypes than those of the PANArray test.
Reaching for the skies: Time and turbulence in digital technologies and practices

This research examines dynamics associated with new representational technologies in complex organizations through a study of the use of a Single Model Environment, prototyping and simulation tools in the mega-project to construct Terminal 5 at Heathrow Airport, London. The ambition of the client, BAA. was to change industrial practices reducing project costs and time to delivery through new contractual arrangements and new digitally-enabled collaborative ways of working. The research highlights changes over time and addresses two areas of 'turbulence' in the use of: 1) technologies, where there is a dynamic tension between desires to constantly improve, change and update digital technologies and the need to standardise practices, maintaining and defending the overall integrity of the system; and 2) representations, where dynamics result from the responsibilities and liabilities associated with sharing of digital representations and a lack of trust in the validity of data from other firms. These dynamics are tracked across three stages of this well-managed and innovative project and indicate the generic need to treat digital infrastructure as an ongoing strategic issue.
Direction-based topology control algorithm for mobile ad-hop networks

The topology of a mobile ad-hop network can be formed by varying transmission power of each node and this topology can be changed frequently by the mobility of nodes. In this paper, we give a detailed analysis of a direction-based distributed topology control algorithm, termed as HCTC(hill climbing topology control). HCTC is presented for improving connectivity and conserving energy over mobile ad-hop wireless networks. Besides outdoor environment which can use GPS information, applying indoor environment we do not assume that nodes have GPS information available; rather, it depends only on directional information. (Angle of Arrival) HCTC is motivated by the stochastic property of the RWP(random waypoint) mobility model(called border effect); we consider that the border effect can affect a node degree of each node in the deployment region and verify it using an analytical model(fDEG). We also devised HCTCREF algorithm to confirm the topology which formed by proposed algorithm. (HCTC). HCTCREF can verify the direction of reference point which determined by HCTC. Simulation results are presented to demonstrate a set of optimization that further reduce power consumption and prove that they retain robust network connectivity.
Community Extraction in Hypergraphs Based on Adjacent Numbers

Community extraction plays an important role in network analysis. This paper discusses communities in hypergraphs. Since hypergraphs can represent multi-relational networks, they are important structures in many domains. In this study, the definition of communities based on the number of adjacent links/nodes is extended to a hypergraph. Four extended models are proposed. The adequacy of these models for hypergraph communities is investigated by using a hypergraph obtained from joint work relationships.
Visualization of Flow Data in Photo-realistic Virtual Environment

of the Master's Thesis Virtual reality technology has been adopted in many different fields and new application areas are searched continuously. At the moment virtual reality has been applied separately for instance to scientific visualization and illustration of architectural spaces. In this work, a photo-realistic room model and a visualization of an air flow inside the room has been combined. The integrated illustrative three-dimensional model is presented within an immersive virtual environment. The first part of the work covers scientific visualization and virtual reality implementation techniques. The visualization review begins with a discussion about human percepion of visual information and proceeds with an introduction to three-dimensional visualization. The focus is on illustration of a flow data produced as a result of a computational simulation. The flow visualization techniques utilizing all three dimensions are discussed and many examples of different graphical elements are presented. Virtual reality is examined from technical solutions point of view. The features having effect on the quality of a virtual experience are discussed and three different commonly used display techniques are introduced. The hardware of Experimental Virtual Environment-facility at Helsinki University of Technology is given as a detailed example. The implementation of a visualization software is described in the applied part of this thesis. Discussion covers the evaluation of different software tools, the tool selection process , and a detailed description of the design principles and implementation of the software. The different visualization solutions are also justified in this part. In the implementation, the real-time system requirements and utilization of all three dimensions have been taken into account. Finally, the results and their meaning are discussed and the performance of the implementation is evaluated. The applied part successfully integrated the room model and the flow visualization in an interactive virtual environment.
A new estimation method of the forestry inventory parameter based on three-dimension laser scan technology

Terrestrial laser scanners, as efficient tools, have opened a wide range of application fields within a rather short period of time. Beyond interactive measurement in 3D point clouds, techniques for the automatic detection of objects and the determination of geometric parameters form a high priority research issue. The quality of 3D point clouds generated by laser scanners and the automation potential make terrestrial laser scanning also an interesting tool for forest inventory and management. The paper will first review current laser scanner systems from a technological point of view and discuss different scanner technologies and system parameters regarding their suitability for forestry applications. Based on a large number of mixed forest plots, accuracy and handling of the laser scanner were tested. Furthermore a method for the automatic detection of the approximate position of trees will be presented. Co-ordinates of the approximate positions and the number of trees in the plots are a result of the first algorithm. In a second step all located trees will be separated and the breast height diameters, the profiles along the stem and their height will be determined automatically. Finally the paper presents results from several pilot studies on the application of terrestrial laser scanning in forest inventory tasks with the goal of automatically determining inventory-relevant tree parameters. The basic data sets have been provided using one terrestrial laser scanners, which based on phase measurement technology.
Environmental Tobacco Smoke Exposure and Children’s Intelligence at 8–11 Years of Age

Background: Evidence supporting a link between postnatal environmental tobacco smoke (ETS) exposure and cognitive problems among children is mounting, but inconsistent. Objectives: We examined the relationship between ETS exposure, measured using urine cotinine, and IQ scores in Korean school-aged children. Methods: The participants were 996 children 8–11 years of age recruited from five administrative regions in South Korea. We performed a cross-sectional analysis of urinary cotinine concentrations and IQ scores obtained using the abbreviated form of a Korean version of the Wechsler Intelligence Scales for Children. Associations were adjusted for potential confounders, and estimates were derived with and without adjustment for mother’s Full-Scale IQ (FSIQ) score. Results: After adjusting for sociodemographic and developmental covariates, urinary cotinine concentrations were inversely associated with FSIQ, Verbal IQ (VIQ), Performance IQ (PIQ), vocabulary, math, and block design scores. Following further adjustment for maternal IQ, only the VIQ scores remained significantly associated with urinary cotinine concentration (B = –0.31; 95% CI: –0.60, –0.03 for a 1-unit increase in natural log-transformed urine cotinine concentration; p = 0.03). Conclusion: Urine cotinine concentrations were inversely associated with children’s VIQ scores before and after adjusting for maternal IQ. Further prospective studies with serial measurements of cotinine are needed to confirm our findings. Citation: Park S, Cho SC, Hong YC, Kim JW, Shin MS, Yoo HJ, Han DH, Cheong JH, Kim BN. 2014. Environmental tobacco smoke exposure and children’s intelligence at 8–11 years of age. Environ Health Perspect 122:1123–1128; http://dx.doi. org/10.1289/ehp.1307088
Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model.

In the first Phase I clinical trials of endostatin as an antiangiogenic therapy for cancer, the protein was administered as an i.v. bolus for approximately 20-30 min each day. This protocol was based on experimental studies in which animals were treated by s.c. bolus once a day. However, it was not clear in the previous studies whether this schedule could be maximized further. Therefore, we developed experimental models involving continuous administration of endostatin to determine the potency and efficacy of this approach. Endostatin was administered to tumor-bearing mice either s.c. or i.p. in single bolus doses. The efficacy of these regimens was compared with endostatin administered continuously via an i.p. implanted mini-osmotic pump. Our results show that endostatin remains stable and active in mini-osmotic pumps for at least 7 days. We show that endostatin injected i.p. is rapidly cleared within 2 h, whereas endostatin administered continuously via mini-osmotic pump maintains systemic concentrations of 200-300 ng/ml for the duration of administration. Furthermore, continuous i.p. administration of endostatin results in more effective tumor suppression at significantly reduced doses (5-fold), compared with bolus administration. Additional experiments using a human pancreatic cancer model in severe combined immunodeficient mice showed that there was a significant decrease in the microvessel density between the treatment groups and the control group. These data show that continuous administration of human endostatin results in sustained systemic concentrations of the protein leading to: (a) increased efficacy manifested as increased tumor regression; and (b) an 8-10-fold decrease in the dose required to achieve the same antitumor effect as the single daily bolus administration of endostatin. On the basis of this approach, an additional clinical trial has been designed and initiated and is under way in two countries.
Towards distributed verification of petri nets properties

The use of distributed or parallel processing gained interest in the recent years to fight the state space explosion problem. Many industrial systems are described with large models, and the state space being even larger, it does not fit completely into the memory of a single computer. In this approach several computers connected over a network cooperate. The state space is then partitionned among these computers, and each of them contributes to the verification by considering its own subspace. In this paper, we address the verification of basic behavioural properties: reachability, liveness and home state and their distributed analysis. In particular, the verification of the latter properties requires the generation of the full state space and the computation of its terminal strongly connected components. Here, we propose to use a distributed Tarjan algorithm to perform this computation. The performance of distributed verification depends on several criteria, e.g. load balancing of the partitionned state space, but also more importantly on a good partitioning. Therefore, choosing an adequate hash function to assign nodes to processors is important.
Gameful Systems: Play in the digital age for young and old.

Games have been used as a tool to introduce older people to digital technology. Here we are developing a gameful system to facilitate the social interactions between older people and young adults in a community run club. We discuss opportunities for gamification as it relates to our current study using a local running group as platform for supporting older people in gaining confidence in integrating digital technologies in their everyday life. We discuss the over arching issue of older people, digital technology usage and participatory design. This provides the background for addressing points of using gameful system to foster empowerment and connection in the intergenerational running group.
Instant expert hunting: building an answerer recommender system for a large scale Q&A website

After years of rapid growth, Q&A websites, such as Yahoo Answers and Baidu Zhidao now start to utilize recommender systems to route questions to potential answerers. Traditional studies on question recommendation on Q&A website usually presume that answerers are always instantly available for askers. They neglect the importance of timely response of answerers to question askers. Such negligence of time-efficiency leads to lower quality of recommender systems, namely the question starvation problem. In this paper, we focus on improving time-efficiency of recommendations on a large scale online Q&A website in order to boost the answer ratio of new posted questions. To achieve this goal, we design an answerer recommender system (ARS) that is capable of instantly routing a new question the potential answerers with the right expertise. We test our system on a real-world large-scale Q&A website. Experimental results demonstrate that compared with a previously used baseline system, in our system both the time-efficiency and the number of answers given to a question are dramatically improved. In addition, we find that timely response to questions can stimulate interactions between question askers and answerers. Such interaction can boost the answer acceptance ratio by askers since it encourages answerers to improve their answers actively and continuously.
Self locomotion of a spherical rolling robot using a novel deformable pneumatic method

The authors have designed and constructed a new type of actuation for a spherical robot. The proposed actuation system consists of a large number of individually inflatable rubber bladders covering a sphere. Inflation of one or more of these bladders imparts a moment to the sphere and coordinated inflation results in a directed motion. Further, the authors introduce a scheme for steering the robot by correctly selecting the proper bladders to inflate so that motive force is developed in a specified direction. The control scheme utilizes a passively rolling inner vehicle with a directional, remotely positioned light source that causes valves housed within the sphere to inflate the designated bladders through optical commutation.
The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus

Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, n = 40), type 2 DM patients without cardiovascular complications (group B, n = 56), and type 2 DM patients with cardiovascular complications (group C, n = 92). The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00–8:00 and 11:00–13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery.
Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior

Bisphenol A (BPA) is a synthetic compound used in the production of many polycarbonate plastics and epoxy resins. It is one of the most widely produced chemicals in the world today and is found in most canned goods, plastics, and even household dust. Exposure to BPA is almost universal: most people have measurable amounts of BPA in both urine and serum. BPA is similar in structure to estradiol and can bind to multiple targets both inside and outside the nucleus, in effect acting as an endocrine disruptor. Research on BPA exposure has accelerated in the past decade with findings suggesting that perinatal exposure to BPA can negatively impact both male and female reproduction, create alterations in behavior, and act as a carcinogen. BPA can have both short term and long term effects with the latter typically occurring through epigenetic mechanisms such as DNA methylation. This review will draw on both human and animal studies in an attempt to synthesize the literature and examine the effects of BPA exposure on reproduction, behavior, and carcinogenesis with a focus on the potential epigenetic mechanisms by which it acts.
Identity verification based on haptic handwritten signatures: Genetic programming with unbalanced data

In this paper, haptic-based handwritten signature verification using Genetic Programming (GP) classification is presented. The relevance of different haptic data types (e.g., force, position, torque, and orientation) in user identity verification is investigated. In particular, several fitness functions are used and their comparative performance is investigated. They take into account the unbalance dataset problem (large disparities within the class distribution), which is present in identity verification scenarios. GP classifiers using such fitness functions compare favorably with classical methods. In addition, they lead to simple equations using a much smaller number of attributes. It was found that collectively, haptic features were approximately as equally important as visual features from the point of view of their contribution to the identity verification process.
Measurement and Modeling of RFID Propagation Channel with in an Indoor Environment

The radio frequency identification (RFID) technology was automatic identify becomes was essential in the service an indoor environment such as contactless smart card and libraries at high frequency in free space transfer function in wireless communication usually consider used Friss's formula for analysis. This paper the RFID propagation channel at 2.45 GHz with indoor environment. The measurement result are evaluation by using Friis's transmission formula to find the magnitude and phase channel transfer function, path loss, and power delay profile. This technique is very useful for analyzed the signal strength and radio propagation loss of RFID transmission signal.
XMM–Newton observations of the relaxed, high‐redshift galaxy cluster ClJ0046.3+8530 at z= 0.62

A detailed analysis of XMM-Newton observations of ClJ0046.3+8530 (z = 0.624) is presented. The cluster has a moderate temperature (kT = 4.1 ± 0.3 keV) and appears to be relaxed. Emission is detected at ≥3σ significance to a radius of 88 per cent of R 200 (the radius enclosing an overdensity of 200 times the critical density at z = 0.624) in a surface brightness profile. A temperature profile (extending to 0.7R 200 ) and hardness ratio map show no significant departures from the global temperature, within the statistical limits of the data. The cluster bolometric X-ray luminosity is L X = (4.3 ± 0.3) x 10 44 erg s -1 , and the total mass derived within R 200 , assuming isothermality and hydrostatic equilibrium, is M 200 = 3.0 +0.6 -0.5 x 10 14 M ○. The gas entropy measured at 0.1 R 200 is compared with a sample of local systems, and found to be consistent with self-similar evolution with redshift. The metallicity, gas density profile slope and gas mass fraction are all consistent with those found in low-z clusters.
Feedback scheduling for real-time control of systems with communication delays

This work is devoted to integrated control-scheduling in the case of real-time control of systems with communications delays, i.e. network induced delay and input output latency. Feedback control of computing resources is tackled to deal with CPU resource variations and unpredictable workload. Thus, two new control schemes are provided for feedback scheduling of single and multi control task systems. Moreover, the system control design takes into account the unknown delays due to the temporal uncertainties that are unavoidable in real-time control. A new method of state feedback control design for discrete time-delay systems is presented in a LMI formulation. Two illustrative examples show the interest of the proposed approach.
An Improved Speech Denoising Method based on Empirical Mode Decomposition

Generally, Speech enhancement aims to improve speech quality and intelligibility of a noise contaminated speech signal by using various signal processing approaches. Removal of a noise from a noisy speech is a common problem; already a vast research was carried out in earlier. However, due to the characteristics of various types of noises, the approaches proposed in earlier are not applicable for all types of noises. In addition, the earlier approaches didn’t focus on the non-linear and non-stationary characteristics on noise environments. EMD is a filtering approach performs efficiently for non-stationary environments. This paper proposes a novel EMDF approach with the inspiration of thresholding to remove the noise from noisy speech sample. The proposed approach also developed a method to select the IMF index for separating the residual low-frequency noise components from the speech estimate, based on the IMF statistics. An experimental study was also done on various types of noise contaminated speech samples like babble noise, restaurant noise and car interior noise at various strengths.