Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling psychotherapy process by time-series panel analysis (TSPA)

Abstract The authors introduce the methodology of aggregated time-series analysis (time-series panel analysis [TSPA]), by which prototypical process patterns are estimated using longitudinal psychotherapy process data. Empirical trajectories of 202 outpatients (15–107 sessions) were available. Presession questionnaires provided measures of patient's well-being and patient's therapy motivation. TSPA was contrasted with growth curve modeling. Fixed effects were estimated in both methods. Unbalanced longitudinal data considering multiple levels can be analyzed. Using Granger causality derived from time-lagged associations, the TSPA pattern revealed feedback relationships between well-being and therapy motivation. Growth curve analysis highlighted logarithmic increases of well-being trajectories. In particular, TSPA can illuminate change mechanisms in psychotherapy field data by its nonexperimental approximation to an analysis of causal dynamic structures.
Stability of Maternal Autonomy Support between Infancy and Preschool Age

The goals of this article were to examine (1) the relative and absolute stability of maternal autonomy support between infancy and preschool age, and (2) the moderating role of child gender, maternal attachment state of mind, and stressful life events. Sixty-nine mother–child dyads participated in five visits when the child was 8, 15, and 18 months, as well as 2 and 3 years. The results suggested that maternal autonomy support is stable in relative terms, but that its mean level decreases over time. Moreover, there was significant relative stability only for mothers of girls, mothers who showed greater coherence of mind with respect to attachment, and mothers who experienced fewer stressful life events. These results speak to the relevance of investigating parent, child, and contextual factors when examining the conditions that promote or hinder stability in parenting behaviors.
Noise estimation in magnetic resonance SENSE reconstructed data

Parallel imaging methods allow to increase the acquisition rate via subsampled acquisitions of the k-space. SENSE is one of the most popular reconstruction methods proposed in order to suppress the artifacts created by this subsampling. However, the SENSE reconstruction process yields to a variance of noise value which is dependent on the position within the image. Hence, the traditional noise estimation methods based on a single noise level for the whole image fail. Accordingly, we propose a novel method to recover the complete spatial pattern of the variance of noise in SENSE reconstructed images up from the sensitivity maps of each receiver coil. Our method fits applications in statistical image processing tasks such as image denoising.
Automated docking analysis provides new insights on protease inhibitor selection for antiretroviral therapy in HIV-1 infection

Antiretroviral drugs may target four key proteins on the HIV life cycle: reverse transcriptase, protease, transmembrane envelope glycoprotein and integrase. Protease inhibitors (PI) were introduced in clinical use in 1995 immediately leading to the emergence of new drug resistant variants. Due to the high mutation rate of the HIV reverse transcriptase and the strong selective pressure imposed by protease inhibitors there are numerous genetic variants of the HIV protease at the individual and population level. Selection of which protease inhibitors to include in a new therapeutic regimen may be well informed by sequencing analysis of the pol gene. However, in heavily treated patients the increasing genetic complexity of the resistant proteases limits the usefulness of genotypic resistance testing to inform therapeutic decisions. The main goal of this study was to develop an in silico method that allows the choice of PIs based on the structural differences found between drug resistant and drug susceptible proteases. Three dimensional (3D) models of the HIV-1 protease were produced for eight sequences with known PI resistance mutations selected from the Stanford HIV Resistance Database and for one control protease without resistance mutations. Ligand-protein automated docking with flexible ligand was subsequently performed for the binding site of each of the proteases with some of the PIs commercially available in Portugal. Using as an example the resistant mutation 48V to analyze 1) protease-PI binding affinity, 2) complexity of the pathway the drugs take to reach the binding site, 3) number of occurrences with free binding energies below zero and their distribution, we show that amprenavir and tipranavir are the PIs of choice to inhibit the replication of HIV strains bearing this mutation. Our preliminary results suggest that this new method may help to inform difficult therapeutic decisions in heavily treated HIV-1 patients.
Group Performance And Interaction

* Introduction and Overview Basic Group Processes * The Experience of Group Membership * Group Influence Group Performance And Interaction * Group Decisionmaking * Social Facilitation * Social Motivation Losses * Social Dilemmas Specific Types Of Groups * Groups in the Workplace * Juries * Computer-Based Groups * Unique Groups * Future Directions in Group Research Summary
Magnetic resonance imaging-guided surgical design: can we optimise the Fontan operation?

Abstract The Fontan procedure, although an imperfect solution for children born with a single functional ventricle, is the only reconstruction at present short of transplantation. The haemodynamics associated with the total cavopulmonary connection, the modern approach to Fontan, are severely altered from the normal biventricular circulation and may contribute to the long-term complications that are frequently noted. Through recent technological advances, spear-headed by advances in medical imaging, it is now possible to virtually model these surgical procedures and evaluate the patient-specific haemodynamics as part of the pre-operative planning process. This is a novel paradigm with the potential to revolutionise the approach to Fontan surgery, help to optimise the haemodynamic results, and improve patient outcomes. This review provides a brief overview of these methods, presents preliminary results of their clinical usage, and offers insights into its potential future directions.
Performance Evaluation of Best-Worst Selection Criteria for Genetic Algorithm

Genetic algorithm’s performance is based on three major factors, which are selection criteria, crossover and mutation operators. Each factor has its own significant role but the selection criteria to choose parents from the population is the key role to running the genetic algorithm. There is a number of selection schemes that have been introduced in literature and all have their own advantages. Most of the selection criterion is chose the parents which give highly optimum values based on the theory that healthy parents produce healthy offspring. In the current study, we proposed a new selection scheme which selects healthy parents as well as unhealthy parents. The novel selection scheme is simple to implement, and it has notable ability to reduce the effected of premature convergence compared to other selection schemes. We apply this new technique along with some traditional selection schemes on six benchmark problems and Simulation studies show a remarkable performance of the proposed selection scheme.
Small stories, big issues: tracing complex subjectivities of high school students in interactional talk

The influences of family, religion, and social, cultural, and economic discourses are deeply inscribed in the practices of young people. This article argues that by tracing ‘small stories’ through their accounts, we can make visible ‘big issues’ in their world views, and come to a better understanding of the complexities of their subjectification processes. Poststructural inquiry and critical discourse analysis (CDA) are used to frame and analyse the positionings of a small group of 16-year-olds to show how they use ‘small stories’ to mount arguments and counterarguments, introduce ‘theories’, and gain support for their views. Their interactions provide as much insight into their identities as what they actually say; therefore, both content and interaction are key analytical foci. These findings have implications for how we choose sections of interviews for fine-grained textual analysis.
Distribution, activity and evidence for the release of an anti-diuretic peptide in the kissing bug Rhodnius prolixus

SUMMARY In the haematophagous insect Rhodnius prolixus, diuresis is accomplished through the combined actions of peptidergic diuretic hormones and 5-HT released from neurohaemal sites on the abdominal nerves. Preliminary work on anti-diuresis in this blood-feeder, previously believed to occur through a decrease in the levels of the diuretic factors, indicates that an anti-diuretic hormone, with properties similar to CAP2b (pELYAFPRVamide; recently renamed Mas-CAPA-1), might also be present in R. prolixus. Here, we present evidence from immunohistochemical analysis that suggests a PRXamide-like neuropeptide may be released from the abdominal neurohaemal sites beginning 3–4 h following feeding; a time that coincides with the cessation of diuresis. We also show evidence for an endogenous factor, isolated from the central nervous system using reversed-phase high performance liquid chromatography, which mimics the effects of Mas-CAPA-1. Specifically, this endogenous anti-diuretic factor inhibits rates of 5-HT-stimulated secretion in a dose-dependent manner and elevates intracellular cGMP levels of Malpighian tubules stimulated with 5-HT.
A Modeling Study of Coarse Particulate Matter Pollution in Beijing: Regional Source Contributions and Control Implications for the 2008 Summer Olympics

Abstract In the last 10 yr, Beijing has made a great effort to improve its air quality. However, it is still suffering from regional coarse particulate matter (PM10) pollution that could be a challenge to the promise of clean air during the 2008 Olympics. To provide scientific guidance on regional air pollution control, the Mesoscale Modeling System Generation 5 (MM5) and the Models-3/Community Multiscale Air Quality Model (CMAQ) air quality modeling system was used to investigate the contributions of emission sources outside the Beijing area to pollution levels in Beijing. The contributions to the PM10 concentrations in Beijing were assessed for the following sources: power plants, industry, domestic sources, transportation, agriculture, and biomass open burning. In January, it is estimated that on average 22% of the PM10 concentrations can be attributed to outside sources, of which domestic and industrial sources contributed 37 and 31%, respectively. In August, as much as 40% of the PM10 concentrations came from regional sources, of which approximately 41% came from industry and 31% from power plants. However, the synchronous analysis of the hourly concentrations, regional contributions, and wind vectors indicates that in the heaviest pollution periods the local emission sources play a more important role. The implications are that long-term control strategies should be based on regional-scale collaborations, and that emission abatement of local sources may be more effective in lowering the PM10 concentration levels on the heavy pollution days. Better air quality can be attained during the Olympics by placing effective emission controls on the local sources in Beijing and by controlling emissions from industry and power plants in the surrounding regions.
Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations

To determine the effects of transforming growth factor-beta (TGF-beta) on the different cell types that exist in bone, cell populations (I- IV), progressively enriched in osteoblastic cells relative to fibroblastic cells, were prepared from fetal rat calvaria using timed collagenase digestions. TGF-beta did not induce anchorage-independent growth of these cells, nor was anchorage-dependent growth stimulated in most populations studied, despite a two- to threefold increase in the synthesis of cellular proteins. In all populations the synthesis of secreted proteins increased 2-3.5-fold. In particular, collagen, fibronectin, and plasminogen activator inhibitor synthesis was stimulated. However, different degrees of stimulation of individual proteins were observed both within and between cell populations. A marked preferential stimulation of plasminogen activator inhibitor was observed in each population, together with a slight preferential stimulation of collagen; the effect on collagen expression being directed primarily at type I collagen. In contrast, the synthesis of SPARC (secreted protein acidic rich in cysteine/osteonectin was stimulated approximately two-fold by TGF-beta, but only in fibroblastic populations. Collectively, these results demonstrate that TGF-beta stimulates matrix production by bone cells and, through differential effects on individual matrix components, may also influence the nature of the matrix formed by different bone cell populations. In the presence of TGF-beta, osteoblastic cells lost their polygonal morphology and alkaline phosphatase activity was decreased, reflecting a suppression of osteoblastic features. The differential effects of TGF- beta on bone cell populations are likely to be important in bone remodeling and fracture repair.
Single instruction stream parallelism is greater than two

Recent studies have concluded that little parallelism (less than two operations per cycle) is available in single instruction streams. Since the amount of available parallelism should influence the design of the processor, it is important to verify how much parallelism really exists. In this study we model the execution of the SPEC benchmarks under differing resource constraints. We repeat the work of the previous researchers, and show that under the hardware resource constraints they imposed, we get similar results. On the other hand, when all constraints are removed except those ~equired by the semantics oft he program, we have found degrees of parallelism in excess of 17 instructions per cycle. Finally, and perhaps most important for exploiting single instruction stream parallelism now, we show that if the hardware is properly balanced, one can sustain from 2.0 to 5.8 instructions per cycle on a processor that is reasonable to design today.
HLA-B 27-Associated Reactive Arthritis : Pathogenetic and Clinical Considerations

INTRODUCTION . 348 HISTORICAL CONSIDERATIONS . 349 PATHOGENESIS.349 Evidence of Chlamydia in the Joints . 349 Evidence of Enteric Pathogens in the Joints . 350 Bacterium-Host Interaction.350 Chlamydial ReA . 350 Enteric ReA.351 Bacterial Target Antigens . 351 Arthritogenic peptides . 351 Bacterial LPS . 352 Bacterial DNA . 352 Host.352 HLA-B27.352 The gut . 353 The joints . 353 Immune Response to Bacteria . 353 Miscellaneous . 354 CLASSIFICATION CRITERIA.354 EPIDEMIOLOGY.354 ETIOLOGIC AGENTS.355 CLINICAL ASPECTS.355 Articular Findings.356 Extra-Articular Findings.356 LABORATORY FINDINGS.357 RADIOGRAPHIC FINDINGS . 357 DIAGNOSIS . 358 PCR Amplification . 359 HLA-B27.360 DIFFERENTIAL DIAGNOSIS.360 COURSE . 361 PROGNOSTIC FACTORS . 361 THERAPY . 362 Nonpharmacologic Approach . 362 Pharmacologic Approach . 362 Acute presentation . 362 Antibiotic use.362 (i) Antibiotic trials in urogenital arthritis . 363 (ii) Antibiotic trials in enteroarthritis . 363 Refractory ReA: second-line therapy.364 REFERENCES . 364
Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis

Two important biologically active compounds were isolated from Mallotus philippensis. The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin (1) and 11-O-galloylbergenin (2). The in vitro antioxidant and antiplasmodial activities of the isolated compounds were determined. For the antioxidant potential, three standard analytical protocols, namely, DPPH radical scavenging activity (RSA), reducing power assay (RPA), and total antioxidant capacity (TAC) assay, were adopted. The results showed that compound 2 was found to be more potent antioxidant as compared to 1. Fascinatingly, compound 2 displayed better EC50 results as compared to α-tocopherol while being comparable with ascorbic acid. The antiplasmodial assay data showed that both the compound exhibited good activity against chloroquine sensitive strain of Plasmodium falciparum (D10) and IC50 values were found to be less than 8 μM. The in silico molecular docking analyses were also performed for the determination of binding affinity of the isolated compounds using P. falciparum proteins PfLDH and Pfg27. The results showed that compound 2 has high docking score and binding affinity to both protein receptors as compared to compound 1. The demonstrated biological potentials declared that compound 2 could be the better natural antioxidant and antiplasmodial candidate.
Relaying in the Presence of Interference: Achievable Rates, Interference Forwarding, and Outer Bounds

The smallest network model that captures relaying in the presence of multiple communicating pairs causing interference to each other is the interference channel with a relay. In this paper, an achievable rate region for the interference channel with a relay is derived. Special cases of strong interference under which this region is the capacity region are presented. The results obtained demonstrate the benefits of interference forwarding at a relay. By forwarding interfering messages, the relay can improve their reception at unintended receivers and, thus, facilitate interference cancellation. We show that intentionally forwarding interfering messages can improve the achievable rates. The achievable rates and interference forwarding gains are also illustrated by numerical results in Gaussian channels. Finally, a sum-rate outer bound to the capacity region of the Gaussian interference channel with a relay is derived and compared with the achievable rate region. The cut-set bound for this channel is also derived and shown to be much looser than the new sum-rate outer bound.
A novel scheme to reduce power supply noise for high-quality at-speed scan testing

High-quality at-speed scan testing, characterized by high small-delay-defect detecting capability, is indispensable to achieve high delay test quality for DSM circuits. However, such testing is susceptible to yield loss due to excessive power supply noise caused by high launch-induced switching activity. This paper addresses this serious problem with a novel and practical post-ATPG X-filling scheme, featuring (1) a test relaxation method, called path keeping X-identification, that finds don't-care bits from a fully-specified transition delay test set while preserving its delay test quality by keeping the longest paths originally sensitized for fault detection, and (2) an X-filling method, called justification-probability-based fill (JP-fill), that is both effective and scalable for reducing launch-induced switching activity. This scheme can be easily implemented into any ATPG flow to effectively reduce power supply noise, without any impact on delay test quality, test data volume, area overhead, and circuit timing.
RE-ENGINEERING THE TELEPHONE SYSTEM

The evolution of the Internet offers the opportunity to redesign how basic communication services are provided. All services, including (multimedia) telephony, radio and television, can be based on a common, packet-switched, connectionless infrastructure of the Internet. Intelligence is placed into end systems for scalability and controllability. This paper discusses the protocols and technologies that might be used for such a full-service Internet, in particular the role of the access network, resource reservation, and signaling.
Biogenic Aldehyde Metabolism in Rat Brain: Subcellular Distribution of Aldose Reductase and Valproate‐Sensitive Aldehyde Reductase

Abstract: Reductase activity towards two aldose substrates has been examined in subcellular fractions prepared from rat brain. The reduction of glucuronate, which is sensitive to inhibition by the anticonvulsant drug sodium valproate, corresponds to the major high‐Km aldehyde reductase in brain. Xylose reduction that is insensitive to valproate inhibition has characteristics consistent with the activity of aldose reductase (EC 1.1.1.21). Both enzymes are predominantly localized in the cytosolic fraction. The significance of the location of these two reductases is discussed in relation to the compartmentation of catecholamine metabolism in brain.
Cultural Politics of Everyday Life: Social Constructionism, Rhetoric and Knowing of the Third Kind

Traditions of argumentation and knowing of the third kind "getting in touch" - the metamethodology of postmodern sciences of mental life power on the margins - a new place for intellectuals to be Vico and the poetics of practical sociality Wittgenstein and psychology - on our "hook up" to reality Rome Harre - realism and the turn to social constructionism Vygotsky, Volosinov and Bakhtin - "thinking" as a boundary phenomenon conversational realities and academic discourses rhetoric and the social construction of cognitivism what is a "personal relationship"? the politics of identity and belonging epilogue - critical "tool-making" and providential eloquence.
Generalized Representation of Syntactic Structures

Analysis of language provides important insights into the underlying psychological properties of individuals and groups. While the majority of language analysis work in psychology has focused on semantics, psychological information is encoded not just in what people say, but how they say it. In the current work, we propose Conversation Level Syntax Similarity Metric-Group Representations (CASSIM-GR). This tool builds generalized representations of syntactic structures of documents, thus allowing researchers to distinguish between people and groups based on syntactic differences. CASSIMGR builds off of Conversation Level Syntax Similarity Metric by applying spectral clustering to syntactic similarity matrices and calculating the center of each cluster of documents. This resulting cluster centroid then represents the syntactical structure of the group of documents. To examine the effectiveness of CASSIM-GR, we conduct three experiments across three unique corpora. In each experiment, we calculate the clustering accuracy and compare our proposed technique to a bagof-words approach. Our results provide evidence for the effectiveness of CASSIM-GR and demonstrate that combining syntactic similarity and tf-idf semantic information improves the total accuracy of group classification.
Handoff rate analysis in heterogeneous cellular networks: a stochastic geometric approach

Horizontal and vertical handoffs are important ramifications of user mobility in multi-tier heterogeneous cellular networks. They directly affect the signaling overhead and quality of calls in the system. However, they are difficult to analyze due to the irregularly shaped network topologies introduced by multiple tiers of cells. In this work, a stochastic geometric analysis framework on user mobility is proposed, to capture the spatial randomness and various scales of cell sizes in different tiers. We derive theoretical expressions for the rates of all handoff types experienced by an active user with arbitrary movement trajectory. Empirical study using real user mobility trace data and extensive simulation are conducted, demonstrating the correctness and usefulness of our analysis.