Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

We studied the immunocytochemical localization of urokinase-type plasminogen activator (u-PA) and the type 1 plasminogen activator inhibitor (PAI-1) in human fibroblasts and sarcoma cells, using both polyclonal and monoclonal antibodies. The u-PA was found to be located at discrete cell-substratum contact sites, and also at areas of cell- cell contacts, whereas PAI-1 was distributed as a homogeneous carpet excluding strialike areas on the substrate under the cells. To confirm the extracellular localization of u-PA and PAI-1, we stained the cells live at 0 degree C before fixation. A double-labeling experiment showed different distribution of u-PA and PAI-1 under the cells, and especially their peripheral parts. The staining pattern of u-PA and PAI- 1 resisted treatment with 0.2% saponin followed by mechanical removal of cells, a method previously reported to isolate focal contact membranes of fibroblasts. We further demonstrated the deposition of u- PA to the contact areas of cells obtained by saponin treatment by zymography, and that of PAI-1 by metabolic labeling, reverse zymography, immunoblotting, and immunoprecipitation. Fibronectin was also present in the preparations. The deposition of both PAI-1 and fibronectin by the sarcoma cells was enhanced, after treating the cells with 10(-6) M dexamethasone. The confinement of u-PA to discrete contact sites and the more uniform distribution of PAI-1 on the cell substratum may explain how cells producing large amounts of enzyme inhibitors can produce PA-mediated focal proteolysis.
A Compact 77% Fractional Bandwidth CMOS Band-Pass Distributed Amplifier With Mirror-Symmetric Norton Transforms

This paper presents the design of a high fractional-bandwidth millimeter-wave band-pass distributed amplifier (BPDA) implemented in a 40 nm (LP) CMOS process. A high-order load impedance with multiple resonant elements is often used to realize wideband amplifiers. However, these implementations require the use of numerous inductors which occupy a prohibitively large amount of silicon area. A mirror-symmetric Norton transformation technique which reduces inductor component values for a wideband amplifier, allowing an area-efficient layout, is described in this paper. The BPDA consumes 34 mW while providing a power-gain of 7 dB from 24-to-54 GHz with less than 2 dB in-band gain-variation. The BPDA has a measured 77% fractional bandwidth, a +11 dBm in-band IIP3, and an in-band noise-figure less than 6.2 dB, while occupying an area of 0.15 mm2.
Effects of yoga exercise on maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity in female patients with skeletal muscle pain syndrome

[Purpose] This study analyzed the effects of yoga exercise on maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity in female patients with skeletal muscle pain syndrome. [Subjects] The subjects were 24 female patients with skeletal muscle pain syndrome. [Methods] The subjects were divided into 2 groups: a yoga exercise group (n = 12) and a non-exercise control group (n = 12). Body composition, maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity were measured before and after a 12-week yoga exercise program. [Results] After the 12-week yoga exercise program, the exercise group exhibited slightly higher maximum oxygen uptake and creatine kinase myocardial bond activity than the control group, but the differences were not statistically significant. In addition, the exercise group exhibited a significant decrease in cortisol level. [Conclusion] Regular and continuous aerobic exercise such as yoga improves body composition, maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity in female patients with skeletal muscle pain syndrome.
Scaling for interfacial tensions near critical endpoints.

Parametric scaling representations are obtained and studied for the asymptotic behavior of interfacial tensions in the full neighborhood of a fluid (or Ising-type) critical endpoint, i.e., as a function both of temperature and of density/order parameter or chemical potential/ordering field. Accurate nonclassical critical exponents and reliable estimates for the universal amplitude ratios are included naturally on the basis of the "extended de Gennes-Fisher" local-functional theory. Serious defects in previous scaling treatments are rectified and complete wetting behavior is represented; however, quantitatively small, but unphysical residual nonanalyticities on the wetting side of the critical isotherm are smoothed out "manually. " Comparisons with the limited available observations are presented elsewhere but the theory invites new, searching experiments and simulations, e.g., for the vapor-liquid interfacial tension on the two sides of the critical endpoint isotherm for which an amplitude ratio -3.25+/-0.05 is predicted.
Clinicopathological and Prognostic Factors in 106 Prostate Cancer Patients Aged ≤55 Years: A Single-Center Study in China

Background Early-onset prostate cancer patients (aged ≤55 years) from Western countries have been well characterized in previous studies. However, the clinicopathological and prognostic characteristics of early-onset Chinese prostate cancer patients have not yet been assessed. This study aimed to examine the clinicopathological and prognostic factors of prostate cancer patients aged ≤55 years in a single Chinese center. Material/Methods One hundred six prostate cancer patients aged ≤55 years with complete clinicopathological data who were treated at our hospital between January 2000 and June 2014 were selected for this study. Survival rate was investigated by Kaplan-Meier analysis, and prognostic factors were examined by univariate and multivariate analysis. Results The median time from the onset of symptoms to diagnosis was 3.5 months (range, 2–55 months). The median time after endocrine therapy to development of androgen-independent prostate cancer was 10.5 months. A total of 54 patients died (50.9%), of whom 96.2% died from prostate cancer. The 1-, 3-, and 5-year overall survival rates were 88.7%, 66.2%, and 36.0%, respectively. Univariate and multivariate analysis showed that T staging, visceral metastasis, pathological pattern, and Gleason sum were independent prognostic factors in these patients. Conclusions Prostate cancer patients aged ≤55 years are often omitted or misdiagnosed in China. Furthermore, the pathology patterns in this age group were mostly complicated with a high degree of malignancy. Late staging, visceral metastasis, pathological pattern, and high Gleason score were independent prognostic factors in these patients. Comprehensive therapy combined with local therapy is an effective treatment strategy.
Factors Associated with Increased Mortality in a Predominantly HIV-Infected Population with Stevens Johnson Syndrome and Toxic Epidermal Necrolysis

Introduction Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening drug reactions with a higher incidence in HIV-infected persons. SJS/TEN are associated with skin and mucosal failure, predisposing to systemic bacterial infection (BSI), a major cause of death. There are limited data on risk factors associated with BSI and and mortality in HIV-infected people with SJS/TEN. Methods We conducted a retrospective study of patients admitted to a university hospital with SJS/TEN over a 3 year period. We evaluated their underlying illnesses, eliciting drugs, predictive value of bacterial skin cultures and other factors associated with mortality and BSI in a predominantly HIV-infected population by comparing characteristics of the patients who demised and those who survived. Results We admitted 86 cases during the study period and 67/86(78%) were HIV-infected. Tuberculosis was the commonest co-morbidity, diagnosed in 12/86(14%) cases. Skin cultures correlated with BSI by the same organism in 7/64(11%) cases and 6/7 were Gram-negative. Two of the 8 cases of Gram-negative BSI had an associated Gram-negative skin culture, although not always the same organism. All 8 fatalities had >30% epidermal detachment, 7 were HIV-infected, 6 died of BSI and 6 had tuberculosis. Conclusions Having >30% epidermal detachment in SJS/TEN carries an increased risk of BSI and mortality. Tuberculosis and BSI are associated with higher risk of death in SJS/TEN. Our data suggests there may be an association between Gram-negative BSI and Gram-negative skin infection.
Anthroponotic Enteric Parasites in Monkeys in Public Park, China

Some infections are known to spread from animals to humans; others, from humans to animals. And some are not so neatly categorized. Recently, 3 diarrhea-causing parasites of humans were found in apparently healthy monkeys in a public park in China. How the monkeys became infected is unknown. It is possible that the parasites were spread from humans. No matter how the monkeys became infected, park visitors are at risk for infection from the monkeys. Park visitors, who are allowed to feed and play with the monkeys, should be informed that they can get diarrhea directly from the monkeys or from contaminated lake or drinking water.
P-norm minimization over intersections of convex sets

We consider the minimization of the ℓp norm subject to convex constraints. The problem considered in this paper may be regarded as a relaxation of a similar problem that employs the ℓ1 norm. We derive the dual problem, which is unconstrained and devise an algorithm for the dual problem by adapting the Douglas-Rachford algorithm. We demonstrate the utility of the algorithm on an experiment and discuss its differences with an existing algorithm.
Model of Hilbert Curve Fractal Antenna Fed by Coplanar Waveguide for Multi-band Wireless Communications

There are many techniques to improve the characteristic of antennas. In this work we use ideas of the fractal. The purpose of this work is to design and analyze Hilbert curve fractal antennas resulting in the empirical model. We use the Zealand program for simulating antennas. The antennas receive and transmit in many frequency resonances. The first frequency resonance is 1.8 GHz band and others are higher than 1.8 GHz. We design a small Hilbert curve fractal antenna. We analyze this antenna by using the concept of resonance frequency that depends on the dimension size of the antenna to yield the model of Hilbert curve antenna that can be used to predict the multi resonance frequency. In the experiment we found that the percent of difference for this model is lower than 4.6%. That model will be helpful for design Hilbert curve fractal antennas.
Distribution of the inositol 1,4,5‐trisphosphate receptor, P400, in adult rat brain

The distribution of the inositol 1,4,5‐trisphosphate receptor protein, P400, was investigated in adult rat brain by immunocytochemistry with the monoclonal antibody 4C11 raised against mouse cerebellar inositol 1,4,5‐trisphosphate receptor protein. Immunoreactive neuronal cell bodies were detected in the cerebral cortex, the claustrum, the endopiriform nucleus, the corpus callosum, the anterior olfactory nuclei, the olfactory tubercle, the nucleus accumbens, the lateral septum, the bed nucleus of the stria terminalis, the hippocampal formation, the dentate gyrus, the caudate‐putamen, the fundus striatum, the amygdaloid complex, the thalamus, the caudolateral part of the hypothalamus, the supramammillary nuclei, the substantia nigra, the pedunculopontine tegmental nucleus, the ventrotegmental area, the Purkinje cells in the cerebellum, the dorsal cochlear nucleus, the subnucleus oralis and caudalis of trigeminal nerve, and the dorsal horn of the spinal cord. Immunoreactive fibres were found in the midial forebrain bundle, the globus pallidus, the stria terminalis, the pyramidal tract, the spinal tract of trigeminal nerve, and the ventral horn of spinal cord. Nerve fibres forming a dense plexus ending in terminal‐like boutons were detected in relation to nonimmunoreactive neurons of the dentate, interpositus, and fastigial nuclei of the cerebellum and around neurons of the vestibular nuclei. This receptor protein binds a specific second messenger, inositol 1,4,5‐trisphosphate, which produces a mobilization of intracellular Ca2+ and a modulation of transmitter release. © 1993 Wiley‐Liss, Inc.
Feed me: motivating newcomer contribution in social network sites

Social networking sites (SNS) are only as good as the content their users share. Therefore, designers of SNS seek to improve the overall user experience by encouraging members to contribute more content. However, user motivations for contribution in SNS are not well understood. This is particularly true for newcomers, who may not recognize the value of contribution. Using server log data from approximately 140,000 newcomers in Facebook, we predict long-term sharing based on the experiences the newcomers have in their first two weeks. We test four mechanisms: social learning, singling out, feedback, and distribution. In particular, we find support for social learning: newcomers who see their friends contributing go on to share more content themselves. For newcomers who are initially inclined to contribute, receiving feedback and having a wide audience are also predictors of increased sharing. On the other hand, singling out appears to affect only those newcomers who are not initially inclined to share. The paper concludes with design implications for motivating newcomer sharing in online communities.
Light source estimation from a single image

One of the most difficult problems in Augmented Reality is how to ensure that the luminance of virtual objects embedded in a real scene is consistent with the real luminance. This paper shows an approach to identifying the illumination information from a single image of a real scene. Based on the assumption that the object used as a light probe has a globally convex shape, we can employ it to determine the illumination information in terms of the direction and the intensity.
Data-driven temporal filters based on maximum mutual information for robust features in speech recognition

Linear discriminant analysis (LDA), principal component analysis (PCA) and minimum classification error (MCE) have been used to derive data-driven temporal filters in order to improve the robustness of speech features for speech recognition. In this paper, the criterion of maximum mutual information (MMI) is proposed for constructing the temporal filters, and detailed comparative analysis among these various approaches are presented and discussed. Experimental results show that the MMI-derived temporal filters significantly improve the recognition performance of the original mel frequency cepstrum coefficients (MFCC) features compared to LDA/PCA/MCE-derived filters. Also, while the MMI-derived filters are combined with the conventional temporal filters, cepstral mean and variance normalization (CMVN), the recognition performance can be further improved.
Night and daytime water relations in five fast‐growing tree species: Effects of environmental and endogenous variables

Our aim was to investigate the responses of night and daytime water fluxes to environmental stimuli and endogenous drivers in 5 tree species with different water‐use strategies. Data analysis revealed that air vapour pressure deficit (VPD) and wind speed were the main drivers of night‐time sap flux density (Fnight) in all studied species. For Populus × wettsteinii, Populus tremula, Betula pendula, and Alnus glutinosa, VPD was also the major driver of daytime sap flux density (Fday). In Alnus incana, VPD explained less from the total variation in Fday than the photosynthetic photon flux density (QP). The Fday versus VPD regression slope decreased significantly (p < .001) in the following sequence P. × wettsteinii = P. tremula > B. pendula > A. glutinosa > A. incana. However, the Fnight versus VPD regression slope declined (p < .05) in sequence P. × wettsteinii > B. pendula > P. tremula > A. incana = A. glutinosa. P. × wettsteinii and B. pendula demonstrated highest net photosynthesis rates (Pn) among the all investigated species. Multiple regression analysis (independent factors: leaf dark respiration rate and sucrose, glucose, and starch contents) revealed that sucrose content was the only factor, which explained variation (R2 = 0.35; p < .01) in predawn leaf conductance (gpd). Our findings suggest that trees ability to open stomata and lose water at night does not depend directly on their daily water‐use strategy but is determined probably by species photosynthetic capacity, growth potential, and nitrogen‐use strategy.
Constructions of Generalized Concatenated Codes and Their Trellis-Based Decoding Complexity

In this article, constructions of generalized concatenated (GC) codes with good rates and distances are presented. Some of the proposed GC codes have simpler trellis complexity than Euclidean geometry (EG), Reed-Muller (RM), or Bose-Chaudhuri-Hocquenghem (BCH) codes of approximately the same rates and minimum distances, and in addition can be decoded with trellis-based multistage decoding up to their minimum distances. Several codes of the same length, dimension, and minimum distance as the best linear codes known are constructed.
Design and analysis of slot coupled cavity for wide band band-stop filter application

This paper presents the analysis of slot coupled cavity for wide band band-stop filter applications. The bandstop filter structure consists of a rectangular cavity fed by a coupling slot milled at the broad wall of a rectangular waveguide. The structure has been analyzed using Multiple Cavity Modeling Technique (MCMT). The analysis has been validated by the excellent agreement obtained between the MCMT data, Ansoft HFSS simulated data and experimental data for a first order filter. Later the structure has been applied for a fourth order band-stop filter to demonstrate its wide band characteristic.
Reverted indexing for feedback and expansion

Traditional interactive information retrieval systems function by creating inverted lists, or term indexes. For every term in the vocabulary, a list is created that contains the documents in which that term occurs and its relative frequency within each document. Retrieval algorithms then use these term frequencies alongside other collection statistics to identify the matching documents for a query. In this paper, we turn the process around: instead of indexing documents, we index query result sets. First, queries are run through a chosen retrieval system. For each query, the resulting document IDs are treated as terms and the score or rank of the document is used as the frequency statistic. An index of documents retrieved by basis queries is created. We call this index a reverted index. With reverted indexes, standard retrieval algorithms can retrieve the matching queries (as results) for a set of documents (used as queries). These recovered queries can then be used to identify additional documents, or to aid the user in query formulation, selection, and feedback.
Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.

PURPOSE Flavopiridol is the first cyclin-dependent kinase inhibitor to enter clinical trials. Activity in gastric cancer xenografts and in a patient with gastric cancer on the phase I trial led to this phase II study of flavopiridol in patients with metastatic gastric cancer. PATIENTS AND METHODS Sixteen patients were entered onto the study, and 14 were assessable for response. Flavopiridol was administered initially at a dose of 50 mg/m(2)/d by continuous infusion for 72 hours every 2 weeks. Assessment of plasma pharmacokinetics was performed in all patients. Peripheral mononuclear cells were collected throughout the 72-hour infusion for determinants of apoptosis. RESULTS There were no major objective responses (exact confidence interval 0% to 23%). One patient achieved a minor response in his liver metastases, though the primary progressed. Other patients exhibited histologic and radiographic evidence of tumor necrosis. Common toxicities included fatigue in 93% of patients (grade 3 or 4 in 27%) and diarrhea in 73% of patients (grade 3 or 4 in 20%). Five patients (33%) developed venous thromboses at the central catheter tip. The studies performed on peripheral mononuclear cells indicated no induction of apoptosis. CONCLUSION Flavopiridol administered as a single agent for 72 hours every 14 days is inactive in the treatment of gastric cancer. The drug also induced an unexpected higher incidence of vascular thrombosis and fatigue than was anticipated from the phase I trials. Future development of flavopiridol will depend on other doses and schedules in combination with chemotherapy.
Predicting Quality of Answer in Collaborative Q/A Community

Community Question Answering (CQA) services have emerged allowing information seekers pose their information need which is questions and receive answers from their fellow users, also participate in evaluating the questions or answers in a variety of topics. Within this community information seekers could interact and get information from a wide range of users, forming a heterogeneous social networks and interaction between users. A question may receive multiple answers from multiple users and the asker or the fellow users could choose the best answer. Freedom and convenience in participation, led to the diversity of the information. In this paper we present a general model to predict quality of information in a CQA by using non textual features. We showing and testing our quality measurement to a collection of question and answer pairs. In the future our models and predictions could be useful for predictor quality information as a recommender system to complete a collaborative learning.
PiNiZoRo: a GPS-based exercise game for families

Obesity is a growing problem among children, due in part to their sedentary lifestyles. Time spent engaged in physical activity is decreasing, while time spent playing computer and video games is on the rise. We leverage children's interest in digital games to encourage families to engage in purposeful walking. We present a GPS-based game, played on a mobile device that uses walking as a primary gameplay mechanic. Our game, PiNiZoRo, includes a fighting game, triggered at points along a real-world route, and a map editor that allows parents and recreation specialists to create custom routes in their neighbourhoods. Results from an initial focus group with parents were positive, as they showed enthusiasm for the concept, implementation, and gameplay.