Miracle-dz/UniFAR-FTUs huggingface dataset:
Achieving Real-time Guarantees in Mobile Ad Hoc Wireless Networks

Timely wireless communication is essential to allow real-time mobile applications, such as communication between mobile robots or inter-vehicle communication to be realized. The real-time event-based communication paradigm has been recognized as an appropriate highlevel communication scheme to connect autonomous components in large distributed control systems [1]. We investigate whether real-time event constraints can be guaranteed in a mobile ad hoc wireless network. In this work in progress paper we present our analysis of the impact of mobile ad hoc wireless networks on achieving real-time guarantees. We introduce our ongoing work on the use of a proactive routing and resource reservation protocol using mobility awareness and prediction to reduce the unpredictability of a dynamic mobile ad hoc wireless network.
From Syllables to Syntax: Multilevel Statistical Learning by 12-Month-Old Infants

To successfully acquire language, infants must be able to track multiple levels of regularities in the input. In many cases, regularities only emerge after some learning has already occurred. For example, the grammatical relationships between words are only evident once the words have been segmented from continuous speech. To ask whether infants can engage in this type of learning process, 12-month-old infants in 2 experiments were familiarized with multiword utterances synthesized as continuous speech. The words in the utterances were ordered based on a simple finite-state grammar. Following exposure, infants were tested on novel grammatical and ungrammatical sentences. The results indicate that the infants were able to perform 2 statistical learning tasks in sequence: first segmenting the words from continuous speech, and subsequently discovering the permissible orderings of the words. Given a single set of input, infants were able to acquire multiple levels of structure, suggesting that multiple levels.
Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis

Combined Janus kinase 1 (JAK1) and JAK2 inhibition therapy effectively reduces splenomegaly and symptom burden related to myelofibrosis but is associated with dose-dependent anemia and thrombocytopenia. In this open-label phase II study, we evaluated the efficacy and safety of three dose levels of INCB039110, a potent and selective oral JAK1 inhibitor, in patients with intermediate- or high-risk myelofibrosis and a platelet count ≥50×109/L. Of 10, 45, and 32 patients enrolled in the 100 mg twice-daily, 200 mg twice-daily, and 600 mg once-daily cohorts, respectively, 50.0%, 64.4%, and 68.8% completed week 24. A ≥50% reduction in total symptom score was achieved by 35.7% and 28.6% of patients in the 200 mg twice-daily cohort and 32.3% and 35.5% in the 600 mg once-daily cohort at week 12 (primary end point) and 24, respectively. By contrast, two patients (20%) in the 100 mg twice-daily cohort had ≥50% total symptom score reduction at weeks 12 and 24. For the 200 mg twice-daily and 600 mg once-daily cohorts, the median spleen volume reductions at week 12 were 14.2% and 17.4%, respectively. Furthermore, 21/39 (53.8%) patients who required red blood cell transfusions during the 12 weeks preceding treatment initiation achieved a ≥50% reduction in the number of red blood cell units transfused during study weeks 1–24. Only one patient discontinued for grade 3 thrombocytopenia. Non-hematologic adverse events were largely grade 1 or 2; the most common was fatigue. Treatment with INCB039110 resulted in clinically meaningful symptom relief, modest spleen volume reduction, and limited myelosuppression.
Viewing seismic velocity anomalies with 3‐D continuous Gaussian wavelets

Seismic velocity anomalies (SVA) have traditionally been viewed as spatial objects. We present a new method for looking at SVA, based on a 3‐D continuous Gaussian wavelet transform. Local spectra of the seismic anomalies are calculated with the wavelet transforms. Two proxy quantities based on wavelets are used for viewing SVA. These proxy quantities are the 3‐D spatial distributions of (1.) the local maxima of the L2‐norm of the seismic anomalies, E‐max, and (2.) the associated local horizontal wavenumber k‐max. The P1200 tomographical model [Zhou 1996] has been used for this purpose. Geographical distributions of E‐max and k‐max yield information which are not obvious from direct visual inspection of SVA. Some examples are the depth extent of the tectonic boundaries and the inference of a plume‐like object beneath the transition zone under Iceland.
Coupling hydrocarbon degradation to anaerobic respiration and mineral diagenesis: theoretical constraints

The diagenetic mineral assemblages in petroleum reservoirs control the formation fluid pH and pCO2. Anaerobic biodegradation of petroleum is controlled by the transfer of electrons from reduced organic species to inorganic, redox sensitive, aqueous and mineral species in many cases through intermediates such as H2 and CH3COO−. The terminal electron accepting reactions induce the dissolution or precipitation of the same minerals that control the ambient pH and pCO2 in petroleum reservoirs. In this study, we develop a model for anaerobic biodegradation of petroleum that couples the production of acetate and H2 to ‘late stage’ diagenetic reactions. The model reveals that the principal terminal electron accepting process and electron donor control the type of diagenetic reaction, and that the petroleum biodegradation rate is controlled through thermodynamic restriction by the minimum ΔG required to support a specific microbial metabolism, the fluid flux and the mineral assemblage. These relationships are illustrated by modeling coupled microbial diagenesis and biodegradation of the Gullfaks oil reservoir. The results indicate that the complete dissolution of albite by acids generated during oil biodegradation and the corresponding elevated pCO2 seen in the Gullfaks field are best explained by methanogenic respiration coupled to hydrocarbon degradation and that the biodegradation rate is likely controlled by the pCH4. Biodegradation of Gullfaks oil by a consortium that includes either Fe3+‐reducing or ‐reducing bacteria cannot explain the observed diagenetic mineral assemblage or pCO2. For octane, biodegradation, not water washing, was the principal agent for removal at fluid velocities <20 m Myr−1.
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity

Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed on subsets of natural killer (NK) cells and T cells, for which no endogenous ligands are known. Here, we show that KLRG1 binds three of the classical cadherins (E-, N-, and R-), which are ubiquitously expressed in vertebrates and mediate cell–cell adhesion by homotypic or heterotypic interactions. By expression cloning using the mouse KLRG1 tetramer as a probe, we identified human E-cadherin as a xenogeneic ligand. We also identified a syngeneic interaction between mouse KLRG1 and mouse E-cadherin. Furthermore, we show that KLRG1 binds N- and R-cadherins. Finally, we demonstrate that E-cadherin binding of KLRG1 prevents the lysis of E-cadherin–expressing targets by KLRG1+ NK cells. These results suggest that KLRG1 ligation by E-, N-, or R-cadherins may regulate the cytotoxicity of killer cells to prevent damage to tissues expressing the cadherins.
Relation between spring water radon anomalies and seismic activity in Garhwal Himalaya

The variations of spring water radon concentration and meteorological parameters were analysed in relation to the seismic activities in Garhwal Himalaya, India. The radon anomalies were classified on the basis of statistical treatment of the daily observations. The precise measurements of water discharge rate from the spring have been made along with radon measurements for earthquake precursory study. The earthquakes with epicentral distances less than 150 km were considered by an empirical relationship. Pre-, co-, and post-seismic changes in the radon concentration were taken carefully into account in the empirical relationship to establish this behaviour as a potential earthquake precursor. The empirical relationship has been validated by the radon data recorded from the spring waters. The magnitudes of the earthquakes were estimated by using the empirical relationship by introducing computed correlation coefficient of radon and meteorological parameters. The calculated magnitude of some local earthquakes matches exactly with the magnitude recorded by the laboratory seismograph. The possible mechanisms that may cause a radon anomaly are also discussed.
ESMART: Energy-Efficient Slice-Mix-Aggregate for Wireless Sensor Network

Wireless sensor network consists of a large number of resource-constrained sensor nodes and is usually deployed in unattended area to collect specific information. Energy consumption is always a major concern in the research field of wireless sensor network. Thus, data aggregation schemes emerged and were deployed for prolonging network lifetime by reducing data transmitted within the network. Meanwhile, along with the wide application of the data aggregation schemes, the security issues of data aggregation have been increasingly drawing attention and the designing of secure data aggregation scheme is becoming a hot spot. In this paper, we proposed an energy-efficient secure data aggregation scheme, ESMART: energy-efficient slice-mix-aggregate based on the technique of data slicing and mixing. The proposed scheme performs secure data aggregation in a more efficient way while keeping a good performance of privacy preservation. And the simulation result shows that the security performance of ESMART scheme is better than that of some existing and widely used schemes.
Holocene environmental change and the Mesolithic-Neolithic transition in north-west Europe: revisiting two models

Abstract Two previously proposed models relating the Mesolithic-Neolithic transition to environmental change in north-west Europe are critically re-examined in the light of accumulating palaeoenvironmental data, and a realistic appraisal of spatial and temporal resolution. The first deals with declining marine productivity in the western Baltic, and the other with a proposed shift to drier, more continental conditions across north-west Europe. Both models are found to be unsatisfactory, although the case for southern Scandinavia seems to hold greater potential, at least for this region. Problems arise in the spatial scale over which climate change models are intended to apply, and over poor chronological resolution. Understanding the extent and nature of climate change at the relevant period, c. 6000/5800 cal. BP, is far from straightforward, as is the chain of causality between this and the adoption of mixed farming as a way of life.
Actin-Depolymerizing Factor2-Mediated Actin Dynamics Are Essential for Root-Knot Nematode Infection of Arabidopsis[C][W]

Reorganization of the actin and microtubule networks is known to occur in targeted vascular parenchymal root cells upon infection with the nematode Meloidogyne incognita. Here, we show that actin-depolymerizing factor (ADF) is upregulated in the giant feeding cells of Arabidopsis thaliana that develop upon nematode infection and that knockdown of a specific ADF isotype inhibits nematode proliferation. Analysis of the levels of transcript and the localization of seven ADF genes shows that five are upregulated in galls that result from the infection and that ADF2 expression is particularly increased between 14 and 21 d after nematode inoculation. Further analysis of ADF2 function in inducible RNA interference lines designed to knock down ADF2 expression reveals that this protein is required for normal cell growth and plant development. The net effect of decreased levels of ADF2 is F-actin stabilization in cells, resulting from decreased F-actin turnover. In nematode-infected plants with reduced levels of ADF2, the galls containing the giant feeding cells and growing nematodes do not develop due to the arrest in growth of the giant multinucleate feeding cells, which in turn is due to an aberrant actin network.
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Ethionamide is an antituberculous drug for the treatment of multidrug-resistant Mycobacterium tuberculosis. This antibiotic requires activation by the monooxygenase EthA to exert its activity. Production of EthA is controlled by the transcriptional repressor EthR, a member of the TetR family. The sensitivity of M. tuberculosis to ethionamide can be artificially enhanced using synthetic ligands of EthR that allosterically inactivate its DNA-binding activity. Comparison of several structures of EthR co-crystallized with various ligands suggested that the structural reorganization of EthR resulting in its inactivation is controlled by a limited portion of the ligand-binding-pocket. In silico simulation predicted that mutation G106W may mimic ligands. X-ray crystallography of variant G106W indeed revealed a protein structurally similar to ligand-bound EthR. Surface plasmon resonance experiments established that this variant is unable to bind DNA, while thermal shift studies demonstrated that mutation G106W stabilizes EthR as strongly as ligands. Proton NMR of the methyl regions showed a lesser contribution of exchange broadening upon ligand binding, and the same quenched dynamics was observed in apo-variant G106W. Altogether, we here show that the area surrounding Gly106 constitutes the molecular switch involved in the conformational reorganization of EthR. These results also shed light on the mechanistic of ligand-induced allosterism controlling the DNA binding properties of TetR family repressors.
Translating Documents into Semantic Documents using Semantic Web and Web2.0

Managing metadata of documents is a difficult and slippery for desktop users. A wide variety of technologies have been applied for supporting requirements of metadata management, ranging from the acquisition, creation, maintenance, retrieval, reuse, and publishing of metadata. We introduce essential concepts of a semantic document and implement the necessary functionality of metadata managing process. We also propose that three tasks are required to facilitate unambiguous representation of metadata in documents: using XMP to store metadata with the file itself, using ontologies to represent semantic concepts and using Social Web services to interact with web based resources. So our approach allows a user to interact and share the resources among a Desktop and Web more easily.
Impact of neutron flux on soft errors in MOS memories

Investigation of the effect of neutrons on MOS memory devices showed that such devices are sensitive to neutrons. Neutron irradiation of DRAMs and SRAMs caused bit errors due to soft errors; however, no errors occurred in FRAMs and flash memories. The irradiation of alpha-rays caused only single-bit-errors, but when neutrons were irradiated, both single-bit-errors and adjacent multi-bit-errors (about 5% of the total) occurred on our results. Soft errors in RAM were estimated not to occur when the energy of the neutron particles is about 5 MeV or less. Two tendencies were identified between the error rate and the collected charge, depending on the device structures. In particular, presence of a triple-well played a significant role for lowering the error rate. Simulation using a simplified two-dimensional model produced results close to the experiment results, in terms of error mode and device configurations.
GVGrid: A QoS Routing Protocol for Vehicular Ad Hoc Networks

In this paper, we present a QoS routing protocol called GVGrid for multi-hop mobile ad hoc networks constructed by vehicles, i.e., vehicular ad hoc networks (VANETs). GVGrid constructs a route on demand from a source (a fixed node or a base station) to vehicles that reside in or drive through a specified geographic region. The goal of GVGrid is to maintain a high quality route, i.e. a robust route for the vehicles movement. Such a route can be used for high quality communication and data transmission between roadsides and vehicles, or between vehicles. The experimental results have shown that GVGrid could provide routes with longer lifetime, compared with an existing routing protocol for VANETs
Understanding Bjerknes Compensation in Atmosphere and Ocean Heat Transports Using a Coupled Box Model

AbstractA coupled box model is used to study the compensation between atmosphere and ocean heat transports. An analytical solution to the Bjerknes compensation (BJC) rate, defined as the ratio of anomalous atmosphere heat transport (AHT) to anomalous ocean heat transport (OHT), is obtained. The BJC rate is determined by local feedback between surface temperature and net heat flux at the top of atmosphere (TOA) and the AHT efficiency. In a stable climate that ensures global energy conservation, the changes between AHT and OHT tend to be always out of phase, and the BJC is always valid. This can be demonstrated when the climate is perturbed by freshwater flux. The BJC in this case exhibits three different behaviors: the anomalous AHT can undercompensate, overcompensate, or perfectly compensate the anomalous OHT, depending on the local feedback. Stronger negative local feedback will result in a lower BJC rate. Stronger positive local feedback will result in a larger overcompensation. If zero climate feedback.
Web-based question answering system for restricted domain based of integrating method using semantic information

In this paper, we propose the construction of a Web-based question answering(QA) system for restricted domain that combined three resource information databases for the retrieval mechanism, including a question & answer database, a special domain documents database and a Web resource retrieved by Google search engine. We describe a new retrieval technique of integrating a probabilistic technique based on OkapiBM25 and a semantic analysis based on an ontology of HowNet knowledge base and a special domain HowNet created for the restricted domain. Furthermore, we provide a method of question expansion by computing word semantic similarity. The system is first developed for a middlesized domain of sightseeing information. The experiments proved the efficiency of our method for restricted domain and it is feasible to transfer to other domains expediently using the proposed method.
Cartographies of the Future: Julie Mehretu's Dynamic Charting of Fluid Spaces

Abstract If maps make meaning by locating us as agents in the world, the dynamic cartographies by the Ethiopian-American painter Julie Mehretu suggest the extent to which the modern project has given way to fragmented social identities and thus to new kinds of spatial awareness. Such excentric space is shot through with other spaces functioning in relation to and interaction with other spaces. In addition, these new spaces both produce and are produced by our active and continuous interchanges with sophisticated technologies in real time and virtual time, which themselves constitute spaces that are unbounded, heterogeneous and fluid, making spatial orientation indeterminate and jagged, ruled by chance and contingency. How can such territories be mapped? What do these cartographies of the future tell us about our present technosocial world? What relationship between the map and its territory do they suggest? That is what this contribution discusses by examining Mehretu's high-velocity urban charts which not only embody these indeterminate, jagged and indeed chaotic facets of spatial orientation and situatedness. Despite their bleakness and the uncertain future emerging from these hybrid fragmented maps, the stor(ies) they tell suggest poetic ways for agents to create new sensibilities and sensualities that do not rely on consumerism or consumption but evoke the potential for collective action and social change.
False prophets: exploring hybrid board/video games

In order to develop technology that promotes social interaction rather than isolation, we are exploring the space between board games and video games. We created a hybrid game that leverages the advantages of both physical and digital media. A custom sensor interface promotes physical interaction around the shared public display while the un-oriented tabletop display encourages players to focus on each other rather than on the interface to the game. The ensuing social interactions define the course that the game takes, while the computer enhances the gaming experience by completing the menial tasks and providing dynamic, exciting environments. Our hybrid board/video game has the potential to enhance natural and enjoyable recreational interaction between friends.
Internalising Survival Values into Science: Sustainability Implementation Science

Science discerns, processes, tests and incorporates changing reality. Human Geography theory acknowledges, as part of science theory evolution, that humans do care, that humans are agents of changing reality and that we have value and knowledge-based preferences of how our collective future may be influenced by our choices and resultant actions and impacts. Climate change, disaster mitigation and sustainability implementation planning are linked aspects of an emerging value system in science: Sustainability Implementation Research (SIR). SIR starts with the value systems of Ecologically Sustainable Development, embraces the rigours of science replication and extends Action Research to take a whole-systems approach using the David Suzuki model. This defines long-term values, principles and processes to achieve sustainability. This paper draws on extensive disaster risk communication and community engagement research and consultancies by the author at Australian national, state and local government levels, with focus on Sustainability Implementation Planning (SIP) in North Queensland and James Cook University, described in this paper.
Alix/AIP1 Antagonizes Epidermal Growth Factor Receptor Downregulation by the Cbl-SETA/CIN85 Complex

ABSTRACT The assembly of the Cbl-SETA/CIN85-endophilin complex at the C terminus of the epidermal growth factor receptor (EGFR) following ligand activation mediates its internalization and ubiquitination. We found that the SETA/CIN85-interacting protein Alix/AIP1, which also binds endophilins, modulates this complex. Alix was found to associate indirectly with EGFR, regardless of its activation state, and with ΔEGFR, which signals at low intensity and does not bind Cbls or SETA/CIN85. In agreement with this, Alix interaction did not occur via SETA/CIN85. However, SETA/CIN85 and Alix were capable of mutually promoting their interaction with the EGFR. Increasing the level of Alix weakened the interaction between SETA/CIN85 and Cbl and reduced the tyrosine phosphorylation of c-Cbl and the level of ubiquitination of EGFR, SETA/CIN85, and Cbls. This antagonism of the Cbl-SETA/CIN85 complex by Alix was reflected in its diminution of EGFR internalization. In agreement with this, small interfering RNA-mediated knockdown of Alix promoted EGFR internalization and downregulation. It has been suggested that SETA/CIN85 promotes receptor internalization by recruiting endophilins. However, Alix was also capable of increasing the level of endophilin associated with EGFR, implying that this is not sufficient to promote receptor internalization. We propose that Alix inhibits EGFR internalization by attenuating the interaction between Cbl and SETA/CIN85 and by inhibiting Cbl-mediated ubiquitination of the EGFR.