Miracle-dz/UniFAR-FTUs huggingface dataset:
Exchange Rate Choices of Microstates

In this paper we first explain why most microstates (countries with less than 2 million inhabitants) have gained independence only in the last 30 years. Despite the higher costs and risks microstates face, their ability to better accommodate local preferences combined with a more integrated world economy probably explains why the benefits of independence have risen. We explain why microstates at independence have chosen either dollarization, currency board arrangements, or fixed exchange rates rather than more flexible forms of exchange rate systems. We then, using the Geweke-Hajvassiliou-Keane multivariate normal simulator, model empirically the determinants of each of the different fixed exchange rate regimes in microstates and analyze the policy implications.
A comparison of serum androgens in pre-eclamptic and normotensive pregnant women during the third trimester of pregnancy

Objective: To compare the serum androgens level during the third trimester of pregnancy between normotensive and pre-eclamptic women. Method: A case–control study was performed on 64 pregnant women with the gestational age of 28–34 weeks. 32 women were pre-eclamptic (case group), and 32 women were normotensive till term gestation (control group). The serum level of androgens including sex hormone binding globulin (SHBG), total and free testosterone, androstenedione (ADD), and dehydroepiandrosterone sulfate (DHEA-S), were compared between the two groups. Results: The women of the two groups had no statistically significant difference according to age, gestational age, BMI (body mass index), parity and fetal sex. Serum level of SHBG (90.86 ± 9.30 vs. 55.86 ± 8.02 nmol/l, p = 0.02), total testosterone (3.70 ± 0.57 vs. 2.06 ± 0.24 ng/ml, p = 0.01), free testosterone (1.28 ± 0. 17 vs. 0. 74 ± 0.07 pg/ml, p = 0.01), and ADD (2.47 ± 0.10 vs. 2.17 ± 0.10 ng/ml, p = 0.04), was higher in the pre-eclamptic women. However, there was no difference between the two groups for DHEA-S (0.75 ± 0.18 vs. 0.51 ± 0.08 μg/ml, p = 0.19). Conclusion: Serum androgen levels during third trimester of pregnancy are higher in pre-eclamptic women and this may propose an effect of androgens in the pathogenesis of pre-eclampsia.
Diet patterns and the risk of renal cell carcinoma

Abstract Objectives: Our objective was to identify food intake patterns that might be associated with the risk of renal cell carcinoma. Design: A total of 461 cases (210 females, 251 males) were age frequency matched to population controls. Diet factors were created using factor analysis of 69 food items from a food-frequency questionnaire. These factors were modelled using logistic regression to identify those associated with renal cell carcinoma. Setting: We investigated the role of diet in the aetiology of renal cell carcinoma using a population-based case–control study conducted in Ontario between 1995 and 1996. Subjects: Cases were Ontario residents 20 to 74 years of age identified through review of pathology reports in the Ontario Cancer Registry. Results: A ‘dessert’ diet factor was positively associated with disease for both sexes (odds ratio estimate (OR) for males = 3.7, 95% confidence interval (CI) 2.0–6.9; OR for females = 1.4, 95% CI 0.8–2.2, for the highest vs. lowest quartile). In males, a ‘beef’ diet factor was identified and was associated with an increased risk of renal cell carcinoma. Furthermore, a ‘juices’ diet factor also showed an association with increased risk in males ( OR = 1.8, 95% CI 1.0–3.1). For females, a positive association was observed between renal cell carcinoma and an ‘unhealthy’ diet factor ( OR = 1.4, 95% CI 0.8–2.4). Conclusions: Our findings confirmed that high-fat and high-protein diets might be risk factors for renal cell carcinoma. The data also suggest an increased risk associated with juice intake, a finding not previously reported.
The Impact of Entrepreneurship Education and Project-Based Education on Students’ Personal Development and Entrepreneurial Intentions at the Lower Levels of the Educational System: Too Much of Two Good Things?

I present an analysis of a survey in which the effect of entrepreneurship education and project-based education on students at lower secondary level is investigated. The results are based on a random sample of 2000 Danish students. The analysis indicates that entrepreneurship education has a positive effect on students’ personal development, and that its effect on entrepreneurial intentions is fully mediated by its effect on students’ self-conception. A finding with important policy implications is that there is a negative interaction effect between entrepreneurship education and project-based education regarding impact on students’ self-conception. The implication of the results is that we should replace project-based education with entrepreneurship education rather than having them run in parallel.
Recent Research on the Economics of Patents

This review surveys recent research on the economics of patents. The topics covered include theoretical and empirical evidence on patents as incentives for innovation, the effectiveness of patents for invention disclosure, patent valuation, and the design of patent systems. We also look at some current policy areas, including software and business method patents, university patenting, and the growth in patent litigation.
Board composition, CEO duality and performance among Malaysian listed companies

This study investigates the roles of board independence and CEO duality on a firm’s performance relying on financial ratios, namely ROA, ROE, EPS and profit margin. This paper argues that if boards and leadership structure are well in place and conform to the practices in other developed countries, the long‐term shareholder value is expected to increase and shareholder interests are also well protected. To test the roles of board independence and CEO duality, data from the KLSE Main Board companies for the 1994‐1996 financial years were used. The 1994‐1996 financial years were chosen because, during this period, the issue of corporate governance in Malaysia was not as prominent as it was during, and after, the 1997/1998 financial crisis. Thus, this period could be considered as the period during which guidelines on the structure of the board of directors were not yet available in Malaysia. The findings, generally, suggest that neither board independence, leadership structure nor the joint effects of these two showed any relations with firm performance. Findings of this study, nonetheless, showed that Malaysian companies’ boards were generally dominated by outside directors and the majority of the companies in the study practiced non‐dual leadership structures. Thus, this evidence suggests that the structure of the boards of directors in Malaysia is largely independent of management and the absence of any dominant personality.
Euro Area Fiscal Policies and the Crisis

In mid-September 2008, a global financial crisis erupted which was followed by the most serious worldwide economic recession for decades. As in many other regions of the world, governments in the euro area stepped in with a wide range of emergency measures to stabilise the financial sector and to cushion the negative consequences for their economies. This paper examines how and to what extent these crisis-related interventions, as well as the fall-out from the recession, have had an impact on fiscal positions and endangered the longer-term sustainability of public finances in the euro area and its member countries. The paper also discusses the appropriate design of fiscal exit and consolidation strategies in the context of the Stability and Growth Pact to ensure a rapid return to sound and sustainable budget positions. Finally, it reviews some early lessons from the crisis for the future conduct of fiscal policies in the euro area. JEL Classification: E5, E2
Mitochondrial permeability transition as a critical coordinating step of apoptosis : a few hard facts

Recent evidence indicates that a profound alteration in mitochondrial function constitutes an obligatory early event of the apoptotic process. The molecular mechanism accounting for this alteration is mitochondrial permeability transition (PT). PT is both sufficient and necessary for apoptosis to occur. Experiments performed in cell-free systems of apoptosis demonstrate that mitochondria undergoing PT release protease activators that can trigger nuclear manifestations of apoptotis. Bcl-2 and its homologs are endogenous regulators of PT. It appears that some types of necrosis, those inhibited by Bcl-2, involve PT. If PT is a rate-limiting event of both apoptosis and necrosis, then downstream events including caspase activation and the bioenergetic consequencesof PTmustdetermine thechoicebetweenbothmodes of cell death. PT without caspase activation would cause necrosis. These findings have important implications for the comprehension of the apoptotic process, for the dichotomy between apoptosis and necrosis, and for the phylogeny of programmed cell death. Apoptosis may have evolved together with the endosymbiotic incorporation of aerobic bacteria (the precursors of mitochondria) into ancestral unicellular eukaryotes.
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

Fatty acid synthase (FAS) is a molecule found in tumor cells from breast carcinomas of patients whose prognosis is very poor. Recently, this molecule has been identified as the key enzyme in fatty acid biosynthesis. This study was done to test the strength of FAS as a prognostic indicator for disease free survival (DFS) and overall survival (OS).
Lower Corneal Temperature in Neuroleptic-Treated vs. Drug-Free Schizophrenia Patients

Antipsychotic drugs (APDs) can decrease core body temperature in schizophrenia patients. Core temperature may correlate with corneal temperature and thus, we hypothesized that neuroleptic-treated schizophrenia patients would display lower corneal temperature compared with drug-free patients. Corneal temperature of 12 typical APD-treated and 9 drug-free male schizophrenia patients was assessed using a FLIR thermal imaging camera. The APD-treated patients exhibited substantially and significantly lower corneal temperature compared with the drug-free patients (31.57 ± 0.98°C vs. 34.55 ± 1.65°C; p < 0.0001). Our results suggest that APDs may decrease corneal/core temperature in schizophrenia patients. The relevance of this finding to the pathophysiology of schizophrenia or to the antipsychotic effect of neuroleptics merit further investigation.
The G-protein Regulator AGS3 Controls an Early Event during Macroautophagy in Human Intestinal HT-29 Cells*

AGS3 contains GoLoco or G-protein regulatory motifs in its COOH-terminal half that stabilize the GDP-bound conformation of the α-subunit of the trimeric Gi3 protein. The latter is part of a signaling pathway that controls the lysosomal-autophagic catabolism in human colon cancer HT-29 cells. In the present work we show that the mRNA encoding for AGS3 is expressed in human intestinal cell lines (Caco-2 and HT-29) whatever their state of differentiation. Together with the full-length form, minute amounts of the mRNA encoding a NH2-terminal truncated form of AGS3, previously characterized in cardiac tissues, were also detected. Both the endogenous form of AGS3 and a tagged expressed form have a localization compatible with a role in the Gαi3–dependent control of autophagy. Accordingly, expressing its non-Gαi3-interacting NH2-terminal domain or its Gαi3-interacting COOH-terminal domain reversed the stimulatory role of AGS3 on autophagy. On the basis of biochemical and morphometric analysis, we conclude that AGS3 is involved in an early event during the autophagic pathway probably prior to the formation of the autophagosome. These data demonstrate that AGS3 is a novel partner of the Gαi3 protein in the control of a major catabolic pathway.
Pricing and hedging basket options to prespecified levels of acceptability

The concept of stress levels embedded in S&P500 options is defined and illustrated with explicit constructions. The particular example of a stress function used is MINMAXVAR. Seven joint laws for the top 50 stocks in the index are considered. The first time changes a Gaussian one factor copula. The remaining six employ correlated Brownian motion independently time changed in each coordinate. Four models use daily returns, either run as Lévy processes or scaled to the option maturity. The last two employ risk-neutral marginals from the VGSSD and CGMYSSD Sato processes. The smallest stress function uses CGMYSSD risk-neutral marginals and Lévy correlation. Running the Lévy process yields a lower stress surface than scaling to the option maturity. Static hedging of basket options to a particular level of acceptability is shown to substantially lower the price at which the basket option may be offered.
A Pilot Study of Topiramate as Monotherapy in the Treatment of Acute Mania

This small-scale pilot study was performed to grossly document safety and any evidence of efficacy of topiramate in bipolar disorder. Ten patients hospitalized for acute mania were given open-label topiramate monotherapy for up to 28 days. The mean Young Mania Rating Scale (YMRS) score decreased from 32 (range, 26–40) at baseline to 22 (range, 2–40) at the end of the study. Five patients exhibited evidence of moderate to marked improvement, three subjects had at least a 50% reduction in YMRS scores, and the other two patients experienced an improvement of 25% to 49% on the YMRS. The preliminary findings of this small series suggest that topiramate may be effective in acute mania. Double-blind controlled trials are now needed to further investigate the efficacy and safety of topiramate in bipolar disorder.
Frustrations in Collaborative Working

Abstract Qualitative evidence from an action research study is used to address the research question ‘how can institutional context help explain frustrations within local collaborations? ’ This study of multi-agency collaboration for local economic strategy in Ireland finds that individual and organization actions at a local level are substantially shaped along paths structured by funding and performance management arrangements of multiple central government departments. The article concludes that any calls for greater collaboration at a local level will produce limited effects without a simultaneous scrutiny of cross-boundary working at the centre.
Realising the Potential of Co-production: Negotiating Improvements in Public Services

The concept of co-production – also called co-creation – is gaining widespread attention as a way to increase user involvement in service provision in the UK. It is usually taken as self-evident that more co-production will improve services. However, it is necessary to be clear about how far and in what ways co-production can improve public services. This article looks at the purported advantages of co-production, and considers how these can best be accessed. A case study workshop involving social housing users and providers, conducted as part of the National Consumer Council-Unison Shared Solutions project, is used to illustrate the need for collective dialogue and deliberation between co-producers rather than purely transactional forms of co-production.
Microvesicles Contribute to the Bystander Effect of DNA Damage

Genotoxic treatments elicit DNA damage response (DDR) not only in cells that are directly exposed but also in cells that are not in the field of treatment (bystander cells), a phenomenon that is commonly referred to as the bystander effect (BE). However, mechanisms underlying the BE remain elusive. We report here that etoposide and ultraviolet (UV) exposure stimulate the production of microvesicles (MVs) in DU145 prostate cancer cells. MVs isolated from UV-treated DU145 and A431 epidermoid carcinoma cells as well as etoposide-treated DU145 cells induced phosphorylation of ataxia-telangiectasia mutated (ATM) at serine 1981 (indicative of ATM activation) and phosphorylation of histone H2AX at serine 139 (γH2AX) in naïve DU145 cells. Importantly, neutralization of MVs derived from UV-treated cells with annexin V significantly reduced the MV-associated BE activities. Etoposide and UV are known to induce DDR primarily through the ATM and ATM- and Rad3-related (ATR) pathways, respectively. In this regard, MV is likely a common source for the DNA damage-induced bystander effect. However, pre-treatment of DU145 naïve cells with an ATM (KU55933) inhibitor does not affect the BE elicited by MVs isolated from etoposide-treated cells, indicating that the BE is induced upstream of ATM actions. Taken together, we provide evidence supporting that MVs are a source of the DNA damage-induced bystander effect.
Racial Disparity in Foster Care Admissions

sUmmARY AND ImpLICATIONs Although the rate of foster care placement within the African American community has been a focal point for some time now, it seems that the issue of racial disproportionality is now gaining real traction as a critical policy and practice issue within the child welfare system. The Government Accountability Office (GAO) recently completed a study of what is known about the issue. State-sponsored research in Texas, Michigan, and Tennessee further attests to the interest in the issue among state child welfare directors (Michigan Advisory Committee on the Overrepresentation of Children of Color in Child Welfare, 2006; Texas Health and Human Services Commission, 2006; Wulczyn, Lery, and Haight, 2006). Within the private sector, the Race Matters Consortium and The Casey/Center for the Study of Social Policy Alliance for Racial Equity in Child Welfare have helped move the issue to the forefront of policy discussions.With these developments in mind, it is important to unpack the issue of disproportionality into the dynamics that define whether one population is overrepresented relative to another. On the one hand, where disproportionality is a function of admission disparities, the strategies for addressing the issue have to focus on entry into care. On the other hand, if disproportionality is more closely tied to how quickly children achieve permanency, then policy and programmatic solutions have to stress the system’s back door. In the more likely event that disproportionality is a function of both entry and exit disparities, policymakers and practitioners will have to put nuanced approaches in place if they hope to solve the problem and monitor success.In this paper, we seek to contribute to this unpacking by looking at disparity in 1,034 counties selected from states that contribute to the Multistate Foster Care Data Archive. The focus is on entry rate disparities, with a special emphasis on age at admission and county characteristics. For county characteristics, we examined a subset of 705 counties and considered the urban character of the county as well as other characteristics of county population. The goal of the analysis is to describe the ways in which disparity differs within populations so that policymakers and practitioners view disproportionality as a multidimensional issue that affects different populations in different ways.
Regulating London's Bus Services 1919–1924: A Reappraisal

Abstract This paper re-examines the events between 1919 and 1924 that culminated in the regulation of London's bus services under the London Traffic Act, 1924. Prior to this, bus services in London were not subject to any form of regulatory control. The commissioner of the Metropolitan Police licensed vehicles under the Metropolitan Public Carriage Act, 1869, and once a licence was granted, the holder had complete freedom of operation. The 1924 act was introduced by Ramsay MacDonald's first Labour government as part of a deal to settle a strike by London's tramway and bus men, and is commonly portrayed as a measure that was enacted in haste to solve this crisis. The evidence presented in this paper demonstrates that plans to regulate London's bus services were longer in the making than is generally supposed, and that the form of control was shaped by influences other than transport and industrial relations. The other factors that form part of this re-examination are the national economic crisis, debate about the structure of London government, and a fresh assessment of the interplay between the transport employers and employees in making common cause for protection from competition.
Using choice experiments to design wetland management programmes: The case of Severn Estuary Wetland, UK

Abstract This paper reports the results of a pilot valuation study, which was undertaken to investigate whether the public located around the Severn Estuary derive positive economic values from its sustainable management. One hundred members of the public took part in a choice experiment, the results of which indicate that overall the public derives positive and significant values from sustainable management of this wetland, however, there is some preference heterogeneity. The findings demonstrate that the choice experiment method is a promising tool, which can aid the design of socially optimal policies for sustainable management of the Severn Estuary, with possible implications for other similar wetlands in the UK.
Measuring Program Impacts on Earnings and Employment: Do Unemployment Insurance Wage Reports from Employers Agree with Surveys of Individuals?

This article attempts to determine whether wage records reported by employers to state unemployment insurance (UI) agencies provide a valid alternative to more costly retrospective sample surveys of individuals as the basis for measuring the impacts of employment and training programs for low‐income persons. We analyze UI data and survey data for a sample of low‐income adults and youths from 12 sites in the National Job Training Partnership Act (JTPA) study. Our comparison indicates that impact estimates based on UI data and survey data were usually comparable. However, average surveyreported earnings were higher than average UI‐reported earnings.
Incentives for Collaborative Governance: Top-Down and Bottom-Up Initiatives in the Swedish Mountain Region

Governance collaborations between public and private partners are increasingly used to promote sustainable mountain development, yet information is limited on their nature and precise extent. This article analyzes collaboration on environment and natural resource management in Swedish mountain communities to critically assess the kinds of issues these efforts address, how they evolve, who leads them, and what functional patterns they exhibit based on Margerum's (2008) typology of action, organizational, and policy collaboration. Based on official documents, interviews, and the records of 245 collaborative projects, we explore the role of the state, how perceptions of policy failure may inspire collaboration, and the opportunities that European Union funds have created. Bottom-up collaborations, most of which are relatively recent, usually have an action and sometimes an organizational function. Top-down collaborations, however, are usually organizational or policy oriented. Our findings suggest that top-down and bottom-up collaborations are complementary in situations with considerable conflict over time and where public policies have partly failed, such as for nature protection and reindeer grazing. In less contested areas, such as rural development, improving tracks and access, recreation, and fishing, there is more bottom-up, action-oriented collaboration. State support, especially in the form of funding, is central to explaining the emergence of bottom-up action collaboration. Our findings show that the state both initiates and coordinates policy networks and retains a great deal of power over the nature and functioning of collaborative governance. A practical consequence is that there is great overlap—aggravated by sectorized approaches—that creates a heavy workload for some regional partners.