Miracle-dz/UniFAR-FTUs huggingface dataset:
The Design of Temperature and Pressure Composite Sensor and the Nonlinear Decoupling Research of Two Parameters

In response to the demand for real-time monitoring of temperature and pressure in harsh environments, a microwave substrate-integrated waveguide (SIW) temperature–pressure composite sensor loaded with complementary split resonant ring (CSRR) structure is proposed in this study for real-time testing of temperature and pressure dual parameters in a high-temperature environment. Based on the sensitive texture of the dielectric constant of the alumina ceramic material to temperature and the sensitive mechanism of the sealed cavity film to pressure, the relationships between the resonance frequency of the sensor and the ambient temperature and the resonance frequency and the pressure were established, respectively. The prepared sensor was tested in high-temperature and high-pressure environments, which showed that the sensor can work stably in 25 °C–1200 °C and 0–700-kPa environments. Furthermore, the nonlinear decoupling model of temperature–pressure two parameters is proposed, and the simultaneous acquisition of temperature-pressure two parameters is successfully realized. The sensor has the advantages of simple structure, small size, high sensitivity, and small environmental interference and has the potential to be applied to multiparameter (temperature, pressure, and other parameters) test in high-temperature environment.
A novel method for determining the wax precipitation temperature in wax-based warm mix asphalt

ABSTRACT To accurately determine the wax precipitation temperature (WPT) of wax-based warm mix asphalt binder, a novel algorithm for WPT calculation was proposed, and the process of wax precipitation in asphalt, as well as the effects of aging, cooling rate, and shear rate on wax precipitation characteristics, were investigated through dynamic shear rheometer (DSR) tests and polarised light microscopy (PLM) experiments. The research findings reveal the following: The refined WPT algorithm exhibits heightened precision compared to the traditional viscosity method, showcasing superior reproducibility and mitigating human-induced errors. During the cooling process, wax molecules become oversaturated, leading to the precipitation of wax crystals and the transformation of asphalt into a solid–liquid two-phase system. The aging of asphalt causes changes in its composition, shifting the phase equilibrium towards favouring wax precipitation. The WPT of asphalt is also influenced by the cooling rate and shear rate, and a larger cooling rate and shear rate will reduce the WPT. Wax crystals are less numerous and more regular in shape at low cooling rates.
Head Injury at Early Ages is Associated with Risk of Parkinson’s Disease (P6.051)

Introduction: The literature on the effect of head injuries on the risk of PD is inconclusive. Some researchers have hypothesized that studies that have seen an effect are simply capturing injury related to pre-clinical PD. However in animal models brain inflammation, which can be initiated by head trauma, has been shown to produce PD-like effects. Furthermore, animal studies have found that early life inflammation in particular is of relevance for PD pathology. Methods: We conducted an unmatched caseecontrol study of 379 neurologist confirmed PD patients and 230 controls from the greater Boston, Massachusetts area with questionnaire data on history of head injury and other covariates. We used multivariable logistic regression to estimate adjusted odds ratios (OR) and their corresponding 95% confidence intervals (CI) for PD. Results: Whenwe excluded injuries that occurred less than 10 years prior to the diagnosis of PD (in order to avoid reverse causation), we found an increased risk of PD associated with a head injury that resulted in a loss of consciousness, but it did not reach statistical significance (OR 1⁄4 1.57; 95% CI 1⁄4 0.89e2.80). We found a significant (p 1⁄4 0.04) effect of age at first head injury. For every 5 year earlier age at first head injury with loss of consciousness the OR for PD was 1.37 (95% CI: 1.01e1.86). Conclusion: Our results suggest that head injury in early life increases the risk of PD. © 2015 Published by Elsevier Ltd.
Silicone-specific identification of trace polydimethylsiloxanes in wines with 2D-diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY-NMR)

Present work stresses a novel analytical approach for increasing the specificity of standard NMR approaches for identifying polydimethylsiloxane (PDMS) and further silicone moieties in wines’ organic extracts, by including a second dimension that correlates chemical shifts with diffusion coefficients by means of pulsed-field gradient diffusion ordered spectroscopy (DOSY-NMR). Each silicone source in wines is unambiguously assigned by correlation of both local chemical environments and by a unique diffusion coefficient value, in turn related to a hydrodynamic radius (RH) that can be obtained with respect proper internal standards. Obtained PDMS diffusion coefficient values and hydrodynamic radii in wines’ extracts, in agreement with expected values, present a selectivity and specificity so far not reported, that positions DOSY-NMR spectroscopy as an alternative in oenology for controlling PDMS limits.
Exploring and Engineering Novel Strong Promoters for High-Level Protein Expression in Bacillus subtilis DB104 through Transcriptome Analysis

Bacillus subtilis is widely employed for recombinant protein expression. B. subtilis DB104 offers a distinct advantage as a protein expression host because it is an extracellular protease-deficient derivative of B. subtilis 168. We have conducted a time-course transcriptome analysis of B. subtilis DB104 in a prior study. In the present study, we identified 10 genes that exhibited strong expression at each time point or all, based on transcriptome data. Subsequently, we assessed the strength of 12 promoters that transcribe these genes using enhanced green fluorescent protein (eGFP) as a reporter. Among these promoters, Psdp and PskfA had the highest expression levels. At 24 h, these two promoters exhibited 34.5- and 38.8-fold higher strength, respectively, than the strength of P43, the control promoter. Consequently, these two promoters were selected for further development. We enhanced these promoters by optimizing spacer length, promoter sequence, Shine–Dalgarno sequence, regulator binding sites, and terminator sequences. As a result, we successfully engineered the most potent protein expression cassette, Psdp-4, which exhibited a 3.84-fold increase in strength compared to the original Psdp promoter. Furthermore, we constructed an expression cassette for a human epidermal growth factor (hEGF) using Psdp-4 to evaluate its general application. The expression level of His tagged hEGF, quantified using ImageJ analysis and applied to SDS-PAGE, reached the highest yield of 103.9 μg/mL under the control of Psdp-4 at 24 h. The expressed hEGF protein was purified, and its bioactivity was confirmed through a cell proliferation assay using HT-29 cells. Our work demonstrates the construction of a highly efficient expression system for B. subtilis DB104 based on transcriptome data and promoter engineering. This system enables rapid, inducer-free protein expression within 24 h. It can be used as a valuable tool for various industrial applications.
Association Between Sarcopenic Complications and Readmission in a Kaifukuki Rehabilitation Ward: A Retrospective Cohort Study

Objectives This study investigated the association between sarcopenia and readmission to the Kaifukuki Rehabilitation Ward. Methods We conducted a retrospective observational study in a Kaifukuki Rehabilitation Ward in Japan. Muscle mass was evaluated using a body composition analyzer (InBody, Tokyo, Japan). Grip strength was measured using a grip dynamometer, and walking speed was measured using a 10-meter walk test. Sarcopenia was characterized based on the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia. The presence or absence of readmission was calculated from the medical charts. This study used Rstudio for statistical analysis (Posit, Boston, USA). To examine the effect of sarcopenia on readmissions, we used the Kaplan-Meier method to estimate readmissions. Differences between curves were assessed using the log-rank test. Results A total of 131 patients were selected during the target period (March 1, 2020, to August 31, 2021). Of these, 12 (9%) were readmitted during the study period. The median patient age was 83 years. The study population consisted of 53 males (40%) and 78 females (60%). Sixty (50%) patients in the no-readmission group and seven (58%) patients in the readmission group had sarcopenia. For readmission, the presence of sarcopenia yielded an unadjusted hazard ratio of 1.37 (95% confidence interval: 0.41 to 4.56) and an adjusted hazard ratio of 1.74 (95% confidence interval: 0.52 to 5.83). Conclusions Sarcopenia may be a prognostic factor for readmission in Kaifukuki Rehabilitation Wards. Therefore, further evaluation is necessary.
AN EXTENSIVE ANALYSIS OF THE PRECURSORS AND CONSEQUENCES OF FINANCIAL LITERACY: A SYSTEMATIC REVIEW

The main objective of this research is to investigate the causes that lead to financial literacy and how they affect people's prosperity and the nation's economic prosperity. This study examines a substantial amount of literature using a diagnostic research technique in order to pinpoint the key factors influencing financial literacy. The complex concept of financial literacy is made up of three parts: financial knowledge, attitude, and behaviour. The findings indicate that, in addition to an individual's gender, age, and academic accomplishments, socioeconomic, family, and cultural factors also have a substantial impact on that person's level of financial competence. The aforementioned factors are crucial in molding a person's understanding of finance, which subsequently impacts their aptitude for handling money and their financial conduct. Ultimately, a strong foundation in financial literacy has led to the ability to provide stability in finances and promote general prosperity. To sum up, it is critical to address the antecedents of financial literacy. Further research opportunities may involve empirical studies to assess the antecedents in different regions and the development of a systematic model for understanding and enhancing financial literacy.
Interplay Between Mechanosensitive Adhesions and Membrane Tension Regulates Cell Motility

The initiation of directional cell motion requires symmetry breaking that can happen with or without external stimuli. During cell crawling, forces generated by the cytoskeleton and their transmission through mechanosen-sitive adhesions to the extracellular substrate play a crucial role. In a recently proposed one-dimensional model [P. Sens, Proc. Natl. Acad. Sci. USA 117 , 24670 (2020)], a mechanical feedback loop between force-sensitive adhesions and cell tension was shown to be sufﬁcient to explain spontaneous symmetry breaking and multiple motility patterns through stick-slip dynamics, without the need to account for signaling networks or active polar gels. We extend this model to two dimensions to study the interplay between cell shape and mechanics during crawling. Through a local force balance along a deformable boundary, we show that the membrane tension coupled with shape change can regulate the spatiotemporal evolution of the stochastic binding of mechanosensitive adhesions. Linear stability analysis identiﬁes the unstable parameter regimes where spontaneous symmetry breaking can take place. Using simulations to solve the fully coupled nonlinear system of equations, we show that, starting from a randomly perturbed circular shape, this instability can lead to keratocyte-like shapes. Simulations predict that different adhesion kinetics and membrane tension can result in different cell motility modes including gliding, zigzag, rotating, and sometimes chaotic movements. Thus, using a minimal model of cell motility, we identify that the interplay between adhesions and tension can select emergent motility modes. DOI: 10.1103/PRXLife.1. 023007
Analyzing Digital Image Processing and Neural Network Models for a Pedestrian Crossing the Road

In a surveillance system, pedestrian detection and monitoring are crucial for a variety of utility functions, including the identification of unexpected events, analysis of human gait, appraisal of congested or congested locations, gender classification, and the detection of elderly people falling. The main objective of researchers is to create surveillance systems that can function in a dynamic environment, yet creating such systems involves significant problems and difficulties. The three stages of pedestrian detection—video gathering, person detection, and its tracking—present these difficulties. The difficulties in filming include shifting lighting, sudden movements, a complicated background, shadows, object distortion, etc. Different stances, occlusion, crowd density, area monitoring, etc. provide problems to human identification and tracking. Lower recognition rates are the effect of these. In this proposed study, a brief overview of surveillance systems is provided, along with comparisons of pedestrian recognition and tracking methods in video surveillance. Here, we attempt to evaluate the effectiveness of our suggested work, to explore various datasets, and to contrast many well-known CNN models, including F2DNet, Pedestron, and EGCL. We can finally determine which model will provide greater accuracy and efficiency for pedestrians crossing roads by comparing these two.
The role of the left ventral occipitotemporal cortex in speech processing—The influence of visual deprivation

The role of the left ventral occipitotemporal cortex (vOT) in reading is well-established in both sighted and blind readers. Its role in speech processing remains only partially understood. Here, we test the involvement of the left vOT in phonological processing of spoken language in the blind (N = 50, age: 6.76–60.32) and in the sighted (N = 54, age: 6.79–59.83) by means of whole-brain and region-of-interest (including individually identified) fMRI analyses. We confirm that the left vOT is sensitive to phonological processing (shows greater involvement in rhyming compared to control spoken language task) in both blind and sighted participants. However, in the sighted, the activation was observed only during the rhyming task and in the speech-specific region of the left vOT, pointing to task and modality specificity. In contrast, in the blind group, the left vOT was active during speech processing irrespective of task and in both speech and reading-specific vOT regions. Only in the blind, the left vOT presented a higher degree of sensitivity to phonological processing than other language nodes in the left inferior frontal and superior temporal cortex. Our results suggest a changed development of the left vOT sensitivity to spoken language, resulting from visual deprivation.
Influence Economic Growth and Percentage of the Unemployed Population to Poverty in Indonesia 2016-2020

Focus on the findings of previous studies (gap research) and different perspectives on economic development and factions living unemployed in poverty inform the implementation of this research. Besides that, regardless of the government's effort to combat poverty, there are still problems with research (phenomenon gap) about Indonesia, where the poverty level is still relatively high. The number of people in poverty in Indonesia is not affected significantly by this thing. This research aims to study How the expansion population and the contributing population to poverty interact. Website official Body Center Statistics was used to gather all research data, which was then processed with analysis panel data regression and testing hypothesis (F test, t-test, and coefficient determination). Findings study show that 1) economic growth has a positive and significant impact on poverty, 2) the level of unemployment has a positive and significant impact on poverty, 2) the level of unemployment impact positive and significant on poverty, and 3) economic growth and level of unemployment impact in a way simultaneously to poverty.
Effects of Long-Term Administration of Bovine Bone Gelatin Peptides on Myocardial Hypertrophy in Spontaneously Hypertensive Rats

The research purpose was to investigate the effects and the underlying molecular mechanisms of bovine bone gelatin peptides (BGP) on myocardial hypertrophy in spontaneously hypertensive rats (SHR). BGP relieved myocardial hypertrophy and fibrosis in SHR rats in a dose-dependent manner by reducing the left ventricular mass index, myocardial cell diameter, myocardial fibrosis area, and levels of myocardial hypertrophy markers (atrial natriuretic and brain natriuretic peptide). Label-free quantitative proteomics analysis showed that long-term administration of BGP changed the left ventricle proteomes of SHR. The 37 differentially expressed proteins in the high-dose BGP group participated in multiple signaling pathways associated with cardiac hypertrophy and fibrosis indicating that BGP could play a cardioprotective effect on SHR rats by targeting multiple signaling pathways. Further validation experiments showed that a high dose of BGP inhibited the expression of phosphoinositide 3-kinase (Pi3k), phosphorylated protein kinase B (p-Akt), and transforming growth factor-beta 1 (TGF-β1) in the myocardial tissue of SHR rats. Together, BGP could be an effective candidate for functional nutritional supplements to inhibit myocardial hypertrophy and fibrosis by negatively regulating the TGF-β1 and Pi3k/Akt signaling pathways.
Uses of Plants by the Indians of the Missouri River Region

A classic of ethnobotany, Uses of Plants by the Indians of the Missouri River Region has been enlarged for this Bison Book edition with thirty drawings, by Bellamy Parks Jansen, of plants discussed by Gilmore. The taxonomic glossary has been updated as well. Readers will find here, conveniently described, the uses that Plains Indians made of the wild plants they collected and of those plants they cultivated for food, clothing, medicine, and ornamentation. This fascinating book, originally published in 1919, reveals cultures that evolved in close harmony with their environment.
Temperature Change Recorded by Tree Ring in Jiuquan during the Period from June to September in Recent 240 Years

Some tree-ring samples were collected with increment borers(5 mm and 15 mm) from 4 sites to study the historical temperature variation in the Qilian Mountains,China.Six different tree-ring parameters(earlywood width,latewood width,maximum latewood density,minimum earlywood density,mean earlywood density and mean latewood density) were obtained from Picea crassifolia tree-ring samples from the west Qilian Mountains.The relationships between different tree-ring parameters and temperature were analyzed in this paper.It was found that there was a closest relationship between summer temperature(from June to September) and tree growth.The correlation analysis revealed that there was a significant relationship between precipitation and earlywood width during the period from June to July.The maximum density and average latewood density were not sensitive to climate change.This study demonstrated that the climatic information can be increased and the paleoclimate reconstruction can be improved by using both the tree ring width and tree ring density data.The results also indicated that it is important to understand the physiological properties of tree species and the local climatic conditions in reconstructing paleoclimate.The latewood width(LWW) and the earlywood width(EWW) were used to reconstruct the mean maximum temperature in Jiuquan from June to September during the period AD 1768-2007,and it can be used to explain the 46.6% of the total temperature variance.The estimated temperature revealed that there were 5 warm periods(1786-1836,1851-1885,1924-1933,1959-1967 and 1988-2007) and 5 cold periods(1768-1785,1837-1850,1886-1923,1934-1958 and 1968-1987),1893(25.47 ℃) and 1961(27.47 ℃) were the most extreme years,and the 1810s and 1890s were the most extreme decades.The estimated temperature values in northwest China were compared with the historical data.Climate warning during the period of 1988-2007 was a negative impact to tree radial growth.The multitaper method(MTM) spectral analysis indicated that there were some interannual cycles for 36.6,11.3,6.1,4.8,3.4,3.0,2.6 and 2.4 years in Jiuquan.Wavelet analysis indicated that there were the 20-40-year climatic cycles in the 20th century.The abrupt change of temperature occurred in 1804,1824,1852,1886,1906,1934,1971 and 1985 respectively.
Anti-Biofilm Effect of Ampicillin-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles Conjugated with Lysostaphin on Methicillin-Resistant Staphylococcus aureus

Staphylococcus aureus exhibits the capacity to develop biofilms on various surfaces, encompassing both living and nonliving substrates, enabling it to develop resistance against the immune system and antibiotics. Therefore, this bacterium can cause numerous challenges in healthcare and treatment systems. The present study aimed to investigate the ampicillin-loaded PLGA nanoparticles’ effect on preventing the methicillin-resistant Staphylococcus aureus (MRSA) biofilm formation when it is conjugated with lysostaphin. With the use of the double emulsion evaporation technique, nanodrug carriers were created. Physicochemical attributes of the nanoparticles, such as particle size, drug loading, PDI, encapsulation efficiency, zeta potential, efficiency of lysostaphin conjugation, and morphology, were measured. Minimum inhibitory concentration (MIC), well diffusion, and other techniques were used to investigate the effect of the produced nanodrug carrier on strains of S. aureus. A toxicity test was conducted to examine the toxic effects of artificially generated nanomedicines on the L929 fibroblast culture. The nanoparticle average size, zeta potential, PDI, lysostaphin conjugation efficiency and drug loading encapsulation efficiency, and in the optimum PLGA-AMP-LYS (F4) formulation were 301.9 ± 32 nm, 0.261 ± 0.010, −19.2 ± 3.4 mV, 18.916 ± 1.6, and 94.53 ± 3.8, 40%, respectively. After 72 hours, neither the well diffusion nor MIC techniques revealed any discernible variation between ampicillin and nanodrug carriers. The biofilm investigation’s findings, however, indicated that compared to the free drug, the hindering effect of the nanodrug carrier was greater after 72 hours. The toxicity test findings revealed that the synthesized nanodrug had no toxic effects on the cells. Given the excellent efficacy of the nanomedicine carrier established in the present study, applying this technology to combat hospital-acquired infections caused by Staphylococcus bacteria could yield significant benefits in managing staphylococcal infections.