Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender Disparity in the Prevalence of Metabolic Syndrome in Korea:Results from the Korea National Health and Nutrition Examination Survey,2012

Objectives: To evaluate gender specific characteristics in the prevalence of metabolic syndrome (MetS) and abnormalities in Korean population using the 2009 Joint Interim Statement of the International Diabetes Federation. Methods: We performed a secondary analysis of data based on the 2012 Korea National Health and Nutrition Examination Survey (KNHANES). MetS prevalence was calculated for 5,935 Korean adults (≥ 20 years of age) by sex and age group. Incidence rates of five MetS risk factors were also assessed. Results: The prevalence of MetS among Koreans was 21.7% (22.9% for men, 20.6% for women). Elderly women after menopause had the highest prevalence of MetS and all five risk factors. Young and middle-aged men had higher prevalence and risk factors of MetS than similarly-aged women, but the rate of MetS in women surged significantly from age 50 and surpassed that of men thereafter. Women had a higher prevalence of low HDL cholesterol than men in all age groups. Of the five MetS risk factors, the prevalence of hypertension was highest (36.0%). About one-third of Korean have hypertension as a main risk factor. Conclusion: We observed a mounting gender disparity with age due to an increase in the prevalence of metabolic abnormalities in female. Preventive strategies including lifestyle interventions and health education about MetS need to be implemented pre-menopausal women and middle-aged men. Therapeutic strategies including drug intervention should be employed for elderly women. In 2012, more than one-fifth of Korean have MetS. These results indicate that MetS is an imperative public health issue that needs to be managed at the national level. Reducing the rates of hypertension and dyslipidemia will be critical to controlling MetS. This study provides not only the latest information but also target population and high risk factors for controlling MetS.
Hippocampal LTP and memory in mouse strains: Is there evidence for a causal relationship?

The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long‐term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenotypical changes is debated. The problem of causality can be addressed in numerous ways. One suggestion is to investigate natural variation in both LTP and memory performance in mouse strains. If variation in synaptic and behavioral phenomena is found, correlation between these traits may be investigated. The advantages and disadvantages of this approach are discussed. An empirical example using four mouse strains is also presented to highlight some general problems. The following arguments are made. First, multiple electrophysiological and behavioral paradigms with idiosyncratic condition characteristics should be conducted to avoid false‐positive findings due to alterations unrelated to memory and its mechanisms. Multiple stimulation and memory protocols may also allow one to study the complexity and multiplicity of processes. Second, analysis of a large number of mouse strains may be needed to avoid false interpretation of results due to spurious gene associations and/or linkage disequilibrium. Third, quantitative genetic analysis using, for example, diallele crosses, may be employed to properly investigate biologically meaningful, i.e., genetic, effects. It is concluded that with the use of additional methods (e.g., QTL analysis, gene expression arrays, and biochemical analysis) providing converging evidence, analysis of mouse strains will be instrumental in addressing the question regarding the role LTP may play in memory. Hippocampus 2002;12:657–666. © 2002 Wiley‐Liss, Inc.
Sleep Restriction Alters the Hypothalamic‐Pituitary‐Adrenal Response to Stress

Chronic sleep restriction is an increasing problem in many countries and may have many, as yet unknown, consequences for health and well being. Studies in both humans and rats suggest that sleep deprivation may activate the hypothalamic‐pituitary‐adrenal (HPA) axis, one of the main neuroendocrine stress systems. However, few attempts have been made to examine how sleep loss affects the HPA axis response to subsequent stressors. Furthermore, most studies applied short‐lasting total sleep deprivation and not restriction of sleep over a longer period of time, as often occurs in human society. Using the rat as our model species, we investigated: (i) the HPA axis activity during and after sleep deprivation and (ii) the effect of sleep loss on the subsequent HPA response to a novel stressor. In one experiment, rats were subjected to 48 h of sleep deprivation by placing them in slowly rotating wheels. Control rats were placed in nonrotating wheels. In a second experiment, rats were subjected to an 8‐day sleep restriction protocol allowing 4 h of sleep each day. To test the effects of sleep loss on subsequent stress reactivity, rats were subjected to a 30‐min restraint stress. Blood samples were taken at several time points and analysed for adrenocorticotropic hormone (ACTH) and corticosterone. The results show that ACTH and corticosterone concentrations were elevated during sleep deprivation but returned to baseline within 4 h of recovery. After 1 day of sleep restriction, the ACTH and corticosterone response to restraint stress did not differ between control and sleep deprived rats. However, after 48 h of total sleep deprivation and after 8 days of restricted sleep, the ACTH response to restraint was significantly reduced whereas the corticosterone response was unaffected. These results show that sleep loss not only is a mild activator of the HPA axis itself, but also affects the subsequent response to stress. Alterations in HPA axis regulation may gradually appear under conditions of long total sleep deprivation but also after repeated sleep curtailment.
“Urban-Rural Integration” in the Earthquake Zone: Sichuan's Post-Disaster Reconstruction and the Expansion of the Chengdu Metropole

One of the more recent movements in China’s policy for periurban planning and development is the pursuit of “town and country integration” (cheng xiang yi ti hua). The officially reframed approach to planning suggests possibilities for the official reconsideration of developmental practice, but entrenched conditions of governance, land, environmental and developmental policy, and the planning profession itself constrain these possibilities. Perhaps no other context in China illustrates these constraints more dramatically than the reconstruction effort underway in Sichuan following the earthquake of May 12, 2008. Cultural, environmental and economic differences among settlements in the earthquake zone vary widely, and local and national leaders frequently mention the opportunity the recovery presents for innovative and sustainable development, but the “cataclysmic” nature of reconstruction investment, and the extremely rapid and construction-dominated approach to recovery has prevented planners from considering local conditions or alternative approaches. If the official earthquake response has served to propel urbanization along preexisting trajectories, local geographical, historical and cultural conditions nevertheless assert themselves, even if informally. The uniquely dense, dispersed and agriculturally productive Chengdu Plain has already shaped a national discourse on urban-rural relations. The expansion of Chengdu’s urban region into the narrow valleys and minority ethnic settlements across the Longmen Mountains presents new and unpredictable challenges for considering how city and country are related.
Money, interest rates and the real activity

This paper examines the effectiveness of monetary aggregates through various nominal interest rates by integrating the financial sector into the Cash-in-Advance (CIA) economy. The model assumes that there are two types of representative agents in the financial sector, which are: productive banks and financial intermediates. The productive banks supply a financial service, which is an exchange technology service to households and financial intermediates receive savings fund from savers and offer loans to borrowers. The monetary expansions are increased banking costs through the rate of inflation. It leads households to use more exchange credit relative to cash at the goods market. Since the number of savings funds is equal to the number of exchange credits used at the goods market, money injections are lower the nominal interest rate on saving as the saving fund increases with exchange credit. By assuming that firms are the only borrowers at the capital market from Fuerst (1992), a lower nominal interest rate on the saving fund reduces the marginal cost of labour and increases labour demand. Meanwhile, the increasing marginal cost of money through the expected inflation effect has a negative effect on labour supply. With labour demand dominating labour supply effects, both output and employment increase with monetary expansion. The paper is able to generate a decreasing nominal interest rate with an increasing money supply with an absence of limited participation monetary shocks from Lucas (1990),and by allowing firms to borrow wage bills payment from financial intermediates, it examines the positive response of aggregate output subject to monetary expansion under flexible price framework.
The efficacy and safety of complete pericardial drainage by means of intrapericardial fibrinolysis for the prevention of complications of pericardial effusion: a systematic review protocol

Introduction Intrapericardial fibrinolysis has been proposed as a means of preventing complications of pericardial effusion such as cardiac tamponade, persistent and recurrent pericardial effusion, and pericardial constriction. There is a need to understand the efficacy and safety of this procedure because it shows promise. Methods and analysis We aim to assess the effects of intrapericardial fibrinolysis in the treatment of pericardial effusion. We will search PubMed, the Cochrane Library, African Journals online, Cumulative Index to Nursing and Allied Health Literature, Trip database, Clinical trials.gov and the WHO International Clinical Trials Registry Platform for studies that evaluate the efficacy and/or safety of complete pericardial fluid drainage by intrapericardial fibrinolysis irrespective of study design, geographical location, language, age of participants, aetiology of pericarditis or types of fibrinolytics. Two authors will do the search independently, screen the search outputs for potentially eligible studies and assess whether the studies meet the inclusion criteria. Discrepancies between the two authors will be resolved through discussion and arbitration by a third author. Data from the selected studies shall be extracted using a standardised data collection form which will be piloted before use. The methodological quality of studies will be assessed using the Cochrane Collaboration's tools for assessing risk of bias for experimental studies and non-randomised studies, respectively. The primary meta-analysis will use random effects models due to expected interstudy heterogeneity. Dichotomous data will be analysed using relative risk and continuous with data mean differences, both with 95% CIs. Ethics and dissemination Approval by an ethics committee is not required for this study as it is a protocol for a systematic review of published studies. The results will be disseminated through a conference presentation and peer-reviewed publication. Review registration number PROSPERO, CRD42014015238.
Incidence of infectious diseases and survival among the Roma population: a longitudinal cohort study.

BACKGROUND Roma ethnicity is greatly affected by tuberculosis (TB), AIDS, injecting drugs use (IDU) and imprisonment. METHODS We assessed the incidence of several health problems by means of a retrospective cohort study performed in Camp de la Bota, Barcelona (Spain). The 380 individuals included in the 1985 TB outbreak investigation were followed-up until 31 December 2008. One hundred ninety-two subjects (50.5%) were men and 188 (49.5%) women. Information sources included questionnaires taken at the time of this outbreak, a population census and other registries from Barcelona and Catalonia. Cox proportional hazards mixed models were employed in the multivariate survival analysis. RESULTS By the end of the follow-up, the survival rate was 79.4%; 50 persons (13.1%) had deceased and 28 (7.3%) had emigrated. The incidence of AIDS was 104 cases per 100 000 person-years of follow-up (pyf), IDU was 240 cases pyf, imprisonment was 642 cases pyf and that of TB was 91 cases pyf. Male survival was lower [hazard ratio (HR) 4.22], when the effect of family was taken into account, than when it was not taken into account (HR 3.67). CONCLUSIONS High incidences of AIDS, TB, IDU, imprisonment and poor survival rates have been observed among Roma. Family was found to be an important factor influencing the survival rates: when not considered, the risk of death among men was underestimated.
An Asynchronous FPGA Block with Its Tech-Mapping Algorithm Dedicated to Security Applications

This paper presents an FPGA tech-mapping algorithm dedicated to security applications. The objective is to implement—on a full-custom asynchronous FPGA—secured functions that need to be robust against side-channel attacks (SCAs). The paper briefly describes the architecture of this FPGA that has been designed and prototyped in CMOS 65 nm to target various styles of asynchronous logic including 2-phase and 4-phase communication protocols and 1-of-n data encoding. This programmable architecture is designed to be electrically balanced in order to fit the security requirements. It allows fair comparisons between different styles of asynchronous implementations. In order to illustrate the FPGA flexibility and security, a case study has been implemented in 2-phase and 4-phase Quasi-Delay-Insensitive (QDI) logic.
Evolutionarily Conserved Polyadenosine RNA Binding Protein Nab2 Cooperates with Splicing Machinery To Regulate the Fate of Pre-mRNA

ABSTRACT Numerous RNA binding proteins are deposited onto an mRNA transcript to modulate posttranscriptional processing events ensuring proper mRNA maturation. Defining the interplay between RNA binding proteins that couple mRNA biogenesis events is crucial for understanding how gene expression is regulated. To explore how RNA binding proteins control mRNA processing, we investigated a role for the evolutionarily conserved polyadenosine RNA binding protein, Nab2, in mRNA maturation within the nucleus. This study reveals that nab2 mutant cells accumulate intron-containing pre-mRNA in vivo. We extend this analysis to identify genetic interactions between mutant alleles of nab2 and genes encoding a splicing factor, MUD2, and RNA exosome, RRP6, with in vivo consequences of altered pre-mRNA splicing and poly(A) tail length control. As further evidence linking Nab2 proteins to splicing, an unbiased proteomic analysis of vertebrate Nab2, ZC3H14, identifies physical interactions with numerous components of the spliceosome. We validated the interaction between ZC3H14 and U2AF2/U2AF65. Taking all the findings into consideration, we present a model where Nab2/ZC3H14 interacts with spliceosome components to allow proper coupling of splicing with subsequent mRNA processing steps contributing to a kinetic proofreading step that allows properly processed mRNA to exit the nucleus and escape Rrp6-dependent degradation.
Autonomy of the Political - Development of the Irish Party System

It is generally accepted that Irish party politics represent a rather incongruous strain within the relatively clear-cut patterns which exist throughout the rest of Western Europe. While some recent research demonstrates a certain limited scope for usefully including Ireland in cross-national comparative frameworks,1 the ultimate uniqueness of the Irish party system in relation to other Western European countries has not been substantially disputed. Much of the difficulty encountered in trying to situate the development of Irish parties within a comparative perspective lies in the problem of definition, in that the two largest parties, Fianna Fdil and Fine Gael, seem incapable of other than sui generis classification, their initial momentum deriving from the positions they adopted in, or as a result of, the civil war.2 The only other major party in Ireland is the Labour party, and while it is classifiable within the cross-national social-democratic tradition, its relative weakness vis-a-vis its larger opponents, and its inability as yet to develop a level of voting support equivalent to most of its European counterparts, simply seem to confirm Ireland's anomalous position.
IDENTIFIKASI DAN MIKROENKAPSULASI MINYAK IKAN YANG MENGANDUNG ASAM LEMAK OMEGA-3

Beberapa ikan pelagis seperti komu/tongkol (au x is tha z a r d), momar ( dec a pt e r u s sp. ) , make/lemuru ( sa r d in e ll a sp . ), lema/kembung (rastrelliger sp . ) dan kawalinya (se l ar sp .) merupakan ikan hasil tangkapan nelayan terbanyak disekitar perairan Maluku. Karena lokasi hidup ikan pelagis berada pada permukaan membuat ikan ini mengandung asam lemak omega3. Penelitian ini bertujuan untuk mengidentifikasi kandungan asam lemak omega-3 ikan pelagis diperairan Maluku dan melakukan mikroenkapsulasi untuk melindungi minyak ikan dari terjadinya oksidasi dan mengubah minyak ikan tersebut dari bentuk cair menjadi bentuk tepung sehingga lebih mudah dalam sistem penanganan. Isolasi minyak ikan dilakukan menggunakan pelarut heksan dan kandungan asam lemaknya diidentifikasi menggunakan GCMS-2010S SHIMADZU. Minyak ikan dengan kandungan asam lemak omega-3 terbaik dimikroenkapsulasi menggunakan gum arab dan etil selulosa. Hasil isolasi minyak ikan dari setiap 50 gram tepung ikan diperoleh sebesar 7 - 8 ml. Identifikasi omega-3 minyak ikan menunjukkan bahwa ikan make/lemuru (sardi n ella sp . ) memberikan hasil terbaik dengan kandungan omega-3 terkomplit dari ikan yang lain. Hasil mikroenkapsulasi ikan make/lemuru (sardinela sp.) dengan gum arab diperoleh kadar air sebesar 0,26 ± 0.05%, kecepatan alir 6,5 gram/detik, dan sudut istirahat 2 7 , 5°. Mikroenkapsulasi menggunakan etil selulosa diperoleh kadar air sebesar 0,14 ± 0,03%, kecepatan alir 6,2 gram/detik, dan sudut istirahat 25,5°. Berdasarkan nilai hubungan antara sudut istirahat dan aliran serbuk maka mikroenkapsulasi yang dihasilkan dapat dibuat menjadi tablet. Kata Kunci: Mikroenkapsulasi, asam lemak, omega-3, gum arab, etil selulosa.
T cell cytokine profiles in childhood asthma

Background: An imbalance of T cell subsets in asthma with a predominance of Th2 type cells has been proposed. The aim of this study was simultaneously to detect surface markers and intracellular production of cytokines in T cells from the airways of children with and without asthma. Methods: Bronchoalveolar lavage (BAL) fluid was obtained by wedging a suction catheter into the distal airway immediately before elective surgery. Cells were stimulated with phorbol 12-myristrate 13-acetate (PMA) and ionomycin and intracytoplasmic cytokine retention was achieved using monensin. The cells were stained with the relevant antibodies and analysed by flow cytometry. Results: No statistical difference was observed between children with atopic asthma, atopic non-asthmatic subjects, and normal controls in the percentage of CD3+ cells producing interleukin (IL)-2 or IL-4. Interferon (IFN)γ+ T cells were, however, present in a much higher percentage than either IL-2 or IL-4 positive cells. The percentage of IFNγ+ T cells was significantly increased in subjects with atopic asthma (median 71.3%, interquartile range (IQR) 65.1–82.2, n=13) compared with both atopic non-asthmatic subjects (51.9%, IQR 37.2–70.3, n=12), p<0.05 and normal controls (58.1%, IQR 36.1–66.1, n=23), p<0.01. Conclusions: These findings indicate that IFNγ producing T cells are more abundant in the airways of children with atopic asthma than in atopic non-asthmatic subjects and controls. The proinflammatory activities of IFNγ may play an important role in the pathogenesis of childhood asthma and may suggest that asthma is not simply a Th2 driven response.
Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.

CONTEXT During the development of endometriotic lesions, excess fibrosis may lead to scarring and to the alterations of tissue function that are the characteristic features of this disease. Enhanced extracellular matrix contractility of endometriotic stromal cells (ECSC) mediated by the mevalonate-Ras homology (Rho)/Rho-associated coiled-coil-forming protein kinase (ROCK) pathway has been shown to contribute to the pathogenesis of endometriosis. DESIGN To assess the use of fasudil, a selective ROCK inhibitor, for the medical treatment of endometriosis-associated fibrosis, the effects of this agent on the cell proliferation, apoptosis, cell cycle, morphology, cell density, and contractility of ECSC were investigated. The effects of fasudil on the expression of contractility-related, apoptosis-related, and cell cycle-related molecules in ECSC were also evaluated. RESULTS Fasudil significantly inhibited the proliferation and contractility of ECSC and induced the cell cycle arrest in the G2/M phase and apoptosis of these cells. Morphological observation revealed the suppression of ECSC attachment to collagen fibers and decrease of cell density by fasudil. The expression of α-smooth muscle actin, RhoA, ROCK-I, and ROCK-II proteins was inhibited by fasudil administration. The expression of the antiapoptotic factors, Bcl-2 and Bcl-X(L), in two-dimensional cultured ECSC were down-regulated by the addition of fasudil, whereas, the expression of p16(INK4a) and p21(Waf1/Cip1) was up-regulated by the addition of fasudil. CONCLUSIONS The present findings suggest that fasudil is a promising agent for the treatment of endometriosis. The inhibition of cell proliferation, contractility, and myofibroblastic differentiation, the attenuation of attachment to collagen fibers, the decrease of cell density, and the induction of cell cycle arrest and apoptosis of ECSC are involved in the active mechanisms of fasudil.
Occurrence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea worldwide. Four categories of antigens have been commonly studied: O serogroup, H serogroup, colonization factor antigens (CFA), and toxins. A database has been complied from published reports of nearly 1,000 ETEC isolates from 18 locations and analyzed to determine the occurrence, distribution, and associations of O serogroup, H serogroup, CFA, and toxin type. Tables listing the associations of antigens are presented. This analysis documents the widespread nature and variety of ETEC. Even the most common combination of antigens, O6:H16 CFA/II LTST, accounted for only 11% of the ETEC isolates in the database. It was isolated from 12 locations. Many phenotypes occurred only once. CFA detection based on enzyme-linked antibodies with polyclonal sera is suggested as the preferred assay. A combination of CFA and toxin-based antigens is suggested as the most practical vaccine.