Miracle-dz/UniFAR-FTUs huggingface dataset:
Fecal Transplantation using a Nasoenteric Tube during an Initial Episode of Severe Clostridium difficile Infection

The incidence of Clostridium difficile infection is increasing worldwide, and its severity and resulting mortality are also on the rise. Metronidazole and oral vancomycin remain the treatments of choice, but there are concerns about treatment failure and the appearance of resistant strains. Furthermore, antibiotic therapy results in recurrence rates of at least 20%. Fecal transplantation may be a feasible treatment option for recurrent C. difficile infection; moreover, it may be an early treatment option for severe C. difficile infection. We report a case of severe C. difficile infection treated with fecal transplantation using a nasoenteric tube during an initial episode. This is the first reported case of fecal transplantation using a nasoenteric tube during an initial episode of C. difficile infection in Korea.
Registration of Complex Free-Form Objects from 3D Image Edge Using the Hausdorff Distance

are imposed. What characterizes our approach is that it The Hausdorff distance [6] [7] is a max-min dis-does not require explicit feature extraction, correspond-tance for comparing two sets. In fact, the Hausdorff dis-ence determination, or Surface normal estimation, an tance can be considered as a metric to measure operation that it is often sensitive to noise. (quantify) the similarity between two sets of points, i.e. the extent to which each point belonging to a model lies
Comparison of two tests of auditory temporal resolution in children with central auditory processing disorder, adults with psychosis, and adult professional musicians

Abstract Objective: Evaluate auditory temporal resolution threshold outcomes across three different populations. Design: Two commercially available tests of auditory gap detection (Random gap detection (RGDT) test, and Gaps-in-noise (GIN) test) were administered to all participants. Study sample: Adult professional musicians (APM) (N = 11, age range 28–61 years); children with central auditory processing disorder (CAPD) (N = 22, age range 7.5–17 years); and first episode psychosis patients (FEP) (N = 17, age range 18–48 years). Results: It was not possible to calculate a threshold for the RGDT for 13 of 22 children with CAPD and for 7 of 17 adults with FEP due to response inconsistency. Analysis of variance (ANOVA) excluding cases that produced inconsistent RGDT results showed that only RGDT thresholds differed across groups (F = 8.73, p = 0.001). Three t-tests comparing test means within group revealed statistically significant differences between the gap detection thresholds obtained with the RGDT vs. the GIN for each group. No significant correlations were seen between RGDT and GIN. Conclusion: Lower/better gap detection thresholds and smaller standard deviations were obtained using the GIN in all three groups. Lack of correlation between the two tests suggests that they may measure different processes.
Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a.

BACKGROUND Clinical trial data have shown that among breast cancer patients who were disease free after 5 years of adjuvant treatment with tamoxifen, further extended treatment with the nonsteroidal aromatase inhibitor letrozole reduces breast cancer recurrence. We examined the efficacy and tolerability of extended adjuvant therapy with another aromatase inhibitor, anastrozole, for 3 years among women who had completed 5 years of adjuvant therapy. METHODS Austrian Breast and Colorectal Cancer Study Group (ABCSG) Trial 6a is an extension of ABCSG Trial 6, in which hormone receptor-positive postmenopausal patients received 5 years of adjuvant tamoxifen, with or without the aromatase inhibitor aminoglutethimide, for the first 2 years of therapy. For ABCSG Trial 6a, patients who were disease free at the end of Trial 6 were randomly assigned to receive either 3 years of anastrozole or no further treatment. Efficacy data were analyzed with the use of a Cox proportional hazards regression model with two-sided P values and Kaplan-Meier curves, and tolerability data were estimated using logistic regression analysis with odds ratios and 95% confidence intervals (CIs). RESULTS ABCSG Trial 6a included 856 patients. At a median follow-up of 62.3 months, women who received anastrozole (n = 387) had a statistically significantly reduced risk of recurrence (locoregional recurrence, contralateral breast cancer, or distant metastasis) compared with women who received no further treatment (n = 469; hazard ratio = 0.62; 95% CI = 0.40 to 0.96, P = .031). Anastrozole was well tolerated, and no unexpected adverse events were reported. CONCLUSIONS These data confirm the benefit of extending adjuvant tamoxifen therapy beyond 5 years with anastrozole compared with no further treatment. Further research is required to define the optimum length of extended adjuvant therapy and to investigate the possibility of tailoring this period to suit different disease types.
Determining the outcome of field‐based competition between two Rhizopogon species using real‐time PCR

Interest in the ecology of ectomycorrhizal (ECM) fungi has increased considerably, but little is known about interspecific interactions among ECM species. We examined competitive interactions between Rhizopogon occidentalis and R. salebrosus at Point Reyes National Seashore, California, USA. At three field sites, species abundances were compared in single‐ and two‐species treatments on Pinus muricata seedlings inoculated with spores. Competition for root tips was assessed using real‐time polymerase chain reaction (PCR) of internal transcribed spacer rDNA. In general, we found strong competitive exclusion of R. salebrosus by R. occidentalis, with ≥ 75% of the seedlings in the two‐species treatment colonized exclusively by R. occidentalis after 5 and 10 months. However, on the seedlings that were co‐colonized, we observed no significant difference in the abundances of R. salebrosus and R. occidentalis, suggesting that once R. salebrosus was established, it was no longer competitively inferior. There were no significant differences in survival, growth, or percentage leaf nitrogen of seedlings colonized with either Rhizopogon species, but both growth and percentage leaf nitrogen were significantly higher for ECM than non‐ECM seedlings. We also observed strong positive correlations between actual ECM root tip weight and that inferred from real‐time PCR for both species, indicating that this method provided an accurate assessment of root tip occupation and hence ECM competitive dynamics. In conjunction with a previous experiment, our results indicate that competition between these two Rhizopogon species occurs similarly in both field and laboratory settings and that when colonizing from spore, timing largely determines the outcome of initial competitive interactions.
Neural Correlates of Spatial Navigation Changes in Mild Cognitive Impairment and Alzheimer’s Disease

Although the memory impairment is a hallmark of Alzheimer’s disease (AD), AD has also been characterized by spatial disorientation, which is present from its early stages. Spatial disorientation in AD manifests itself in getting lost in familiar and unfamiliar places and have been characterized more specifically using spatial navigation tests in both real space and virtual environments as an impairment in multiple spatial abilities, including allocentric and egocentric navigation strategies, visuo-spatial perception, or selection of relevant information for successful navigation. Patients suffering mild cognitive impairment (MCI), who are at a high risk of development of dementia, show impairment in a subset of these abilities, mainly connected with allocentric and egocentric processing. While spatial disorientation in typical AD patients probably reflects neurodegenerative changes in medial and posterior temporal, parietal, and frontal lobes, and retrosplenial cortex, the impairment of spatial navigation in MCI seem to be connected mainly with the medial temporal and also parietal brain changes. In this review, we will summarize the signs of brain disease in most MCI and AD patients showing in various tasks of spatial memory and navigation.
Secure Mobile Agents on Ad Hoc Wireless Networks

This paper describes SWAT, a Secure Wireless Agent Testbed. Our goal is to create an integrated environment to study information assurance for mobile agent systems on ad hoc wireless networks. The present SWAT consists of dozens of mobile hosts, both PDAs and laptops, and hundreds of both static and mobile software agents. In deploying the testbed, we have developed novel mechanisms for integrating autonomous agent technologies with public-key and symmetric key encryption to support secure communication, at multiple OSI layers, among groups of hosts and agents. The paper describes the architectural technology used in SWAT, the integration challenges, as well as applications for group collaboration, network health monitoring and system security at both the agent and the host level.
Pattern Field Classification with Style Normalized Transformation

Field classification is an extension of the traditional classification framework, by breaking the i.i. d. assumption. In field classification, patterns occur as groups (fields) of homogeneous styles. By utilizing style consistency, classifying groups of patterns is often more accurate than classifying single patterns. In this paper, we extend the Bayes decision theory, and develop the Field Bayesian Model (FBM) to deal with field classification. Specifically, we propose to learn a Style Normalized Transformation (SNT) for each field. Via the SNTs, the data of different fields are transformed to a uniform style space (i.i.d. space). The proposed model is a general and systematic framework, under which many probabilistic models can be easily extended for field classification. To transfer the model to unseen styles, we propose a transductive model called Transfer Bayesian Rule (TBR) based on self-training. We conducted extensive experiments on face, speech and a large-scale handwriting dataset, and got significant error rate reduction compared to the state-of-the-art methods.
Aqueous Fraction of Nephelium ramboutan-ake Rind Induces Mitochondrial-Mediated Apoptosis in HT-29 Human Colorectal Adenocarcinoma Cells

The aim of this study was to investigate the cytotoxic and apoptotic effects of Nephelium ramboutan-ake (pulasan) rind in selected human cancer cell lines. The crude ethanol extract and fractions (ethyl acetate and aqueous) of N. ramboutan-ake inhibited the growth of HT-29, HCT-116, MDA-MB-231, Ca Ski cells according to MTT assays. The N. ramboutan-ake aqueous fraction (NRAF) was found to exert the greatest cytotoxic effect against HT-29 in a dose-dependent manner. Evidence of apoptotic cell death was revealed by features such as chromatin condensation, nuclear fragmentation and apoptotic body formation. The result from a TUNEL assay strongly suggested that NRAF brings about DNA fragmentation in HT-29 cells. Phosphatidylserine (PS) externalization on the outer leaflet of plasma membranes was detected with annexin V-FITC/PI binding, confirming the early stage of apoptosis. The mitochondrial permeability transition is an important step in the induction of cellular apoptosis, and the results clearly suggested that NRAF led to collapse of mitochondrial transmembrane potential in HT-29 cells. This attenuation of mitochondrial membrane potential (Δψm) was accompanied by increased production of ROS and depletion of GSH, an increase of Bax protein expression, and induced-activation of caspase-3/7 and caspase-9. These combined results suggest that NRAF induces mitochondrial-mediated apoptosis.
Stochastic Approximation in Monte Carlo Computation

The Wang–Landau (WL) algorithm is an adaptive Markov chain Monte Carlo algorithm used to calculate the spectral density for a physical system. A remarkable feature of the WL algorithm is that it is not trapped by local energy minima, which is very important for systems with rugged energy landscapes. This feature has led to many successful applications of the algorithm in statistical physics and biophysics; however, there does not exist rigorous theory to support its convergence, and the estimates produced by the algorithm can reach only a limited statistical accuracy. In this article we propose the stochastic approximation Monte Carlo (SAMC) algorithm, which overcomes the shortcomings of the WL algorithm. We establish a theorem concerning its convergence. The estimates produced by SAMC can be improved continuously as the simulation proceeds. SAMC also extends applications of the WL algorithm to continuum systems. The potential uses of SAMC in statistics are discussed through two classes of applications, importance sampling and model selection. The results show that SAMC can work as a general importance sampling algorithm and a model selection sampler when the model space is complex.
Self-collision detection and prevention for humanoid robots

We present an approach to self-collision detection suitable for complex articulated robots such as humanoids. Preventing self-collisions is vital for the safe operation of robots that generate body trajectories online. Our approach uses a fast distance determination method for convex polyhedra in order to conservatively guarantee that a given trajectory is free of self-collision. Experimental results using an online joystick control application for the humanoid robot "H7" demonstrate the feasibility and effectiveness of the method.
Reduced lung function due to biomass smoke exposure in young adults in rural Nepal

This study aimed to assess the effects of biomass smoke exposure on lung function in a Nepalese population, addressing some of the methodological issues seen in previous studies. We carried out a cross-sectional study of adults in a population exposed to biomass smoke and a non-exposed population in Nepal. Questionnaire and lung function data were acquired along with direct measures of indoor and outdoor air quality. Ventilatory function (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and forced expiratory flow at 25–75% of FVC) was significantly reduced in the population using biomass across all age groups compared to the non-biomass-using population, even in the youngest (16–25 yrs) age group (mean FEV1 (95% CI) 2.65 (2.57–2.73) versus 2.83 (2.74–2.91) L; p=0.004). Airflow obstruction was twice as common among biomass users compared with liquefied petroleum gas users (8.1% versus 3.6%; p<0.001), with similar patterns for males (7.4% versus 3.3%; p=0.022) and females (10.8% versus 3.8%; p<0.001), based on the lower limit of normal. Smoking was a major risk factor for airflow obstruction, but biomass exposure added to the risk. Exposure to biomass smoke is associated with deficits in lung function, an effect that can be detected as early as the late teenage years. Biomass smoke and cigarette smoke have additive adverse effects on airflow obstruction in this setting.
Assessment of elastosis in invasive ductal carcinoma of the breast compared to fibroadenoma among Sudanese patients using conventional histochemical methods

We aimed to identify, using histochemical methods, the degree of elastosis in a malignant breast tumor compared to a benign tumor. Sixty-four tissue blocks were used in this study of which 34 (53.1%) were Invasive ductal carcinoma (IDC) (cases) and 30 (46.8%) were fibroadenomas (controls). Examination of Verhoeff's stained sections revealed different grades of elastosis in 29 (85.2%) cases compared to seven (23.3%) in controls. These findings indicated that elastosis was a prominent feature of IDC (p < 0.000). IDC was associated with more frequent occurrence of different grades of elastosis and should, therefore, be considered a valuable histological finding. Nevertheless, more advanced technology for quantitative measurements of the staining density is recommended to confirm this variation.
Corrosion-Induced Concrete Cracking Model Considering Corrosion-Filled Paste

A TCP–TCL model is established to describe the relationship between the thickness of the corrosion-filled paste (CP) and that of the corrosion layer (CL). This model can describe the phenomenon that the corrosion filling in the concrete pores and accumulating at the steel/concrete interface occur synchronously. Based on the TCP–TCL model, a corrosion-induced concrete cracking model, which can quantitatively consider corrosion-filled paste at concrete/steel interface, is proposed. Combined with damage analysis in corrosion-induced cracking process of concrete cover, the model is developed to describe the quantity of steel corrosion required to crack the concrete surface.
B2b eMarketplaces: A classification framework to analyse business models and critical success factors

Purpose – The purpose of the paper is to look in depth at the role of business‐to‐business (B2b) eMarketplaces in supporting B2b relationships, identifying the successful business models and the related critical success factors (CSFs), and to propose a new classification framework to classify eMarketplace business models. Design/methodology/approach – The paper is based on the analysis of 30 international eMarketplaces through case study methodology. Findings – Nine different business models are identified, which can be classified in terms of a service‐provisioning model and supported processes between companies. For each business model, different CSFs are highlighted. Research limitations/implications – The study has been conducted on a sample of 30 significant international eMarketplaces. Future studies could apply the framework to other cases in specific industries. Originality/value – The paper offers an overview of the eMarketplace business models linking them with the most relevant CSFs. On one hand, the identified CSFs must be considered by managers and entrepreneurs launching new eMarketplaces or managing existing ones, in order to define the strategy, the business model, and the value proposition for the company users. On the other hand, managers facing the problem of adopting internet technology to support a B2b relationship with business partners must learn to distinguish between the different B2b business models, in order to understand their impact on processes and more precisely evaluate the potential value offered by a B2b electronic intermediary.
Trypsin Action on the Growth of Sendai Virus in Tissue Culture Cells

Sendai virus grown in fertile eggs (egg Sendai) infects L cells in which the synthesis of L Sendai (grown in L cells) occurs by the one-step mechanism. L Sendai is not infectious for L cells when tested by the tube titration method although it is infectious for chick embryos. When L cells infected with egg Sendai were dispersed by trypsin and plated on a monolayer culture of L cells, the viral agents spread to the adjacent recipient cells in which the synthesis of L Sendai occurred. The newly infected L cells became infectious for L cells again by trypsin treatment. Kinetic experiments suggested that the target of trypsin is the mature virus, of L Sendai nature, just budding from the L-cell surface. By using an immunofluorescent cell-counting technique, recovery of the infectivity of L Sendai for L cells due to a direct enzymatic action of trypsin was demonstrated. Under the optimal condition, the infectivity increased 1,000-fold for L cells and 10-fold for chick embryos, and both the titers could favorably be compared. No increasing effect of trypsin was observed on the infectivity of egg Sendai. Density centrifugation studies revealed a difference between egg Sendai and L Sendai in the density. Trypsin treatment which induced the maximal enhancement of L Sendai infectivity did not affect both the densities, showing that variations of Sendai virus in the infectivity for L cells and in the density are independent types of host-controlled modification.
MRF4 gene expression in Xenopus embryos and aneural myofibers

Vertebrate embryos express the transcription factor MRF4 during skeletal muscle differentiation. Previous studies of MRF4 expression in embryonic Xenopus laevis and its response to muscle denervation in adults have led to the suggestion that its transcription may be activated in myotomes and in multinucleate myofibers through an interaction with the motor nerves. We tested this hypothesis by assaying for MRF4 gene transcripts in early neurula stage embryos, beginning before the appearance of neurons. MRF4 transcripts were detectable by reverse transcriptase‐polymerase chain reaction (RT‐PCR) from at least stage 13–14, well before the differentiation of either nerves or myocytes. We also tested the nerve‐dependence of MRF4 gene expression in multinucleate myofibers by comparing transcript levels between interhyoideus muscles in normal larvae and muscles whose motor innervation had been prevented through surgical removal of the brain before cranial motor axon outgrowth. RT‐PCR demonstrated similar MRF4 transcript levels in the aneural muscles and controls. These results fail to support the hypothesis that MRF4 gene expression is triggered or is significantly up‐regulated in myogenic cells by signals from motor axons. © 2003 Wiley‐Liss, Inc.
Controlling the onset of turbulence by streamwise travelling waves. Part 2. Direct numerical simulation

This study builds on and confirms the theoretical findings of Part 1 of this paper (Moarref & Jovanović, J. Fluid Mech., 2010, doi:10.1017/S0022112010003393). We use direct numerical simulation of the Navier–Stokes equations to assess the efficacy of blowing and suction in the form of streamwise travelling waves for controlling the onset of turbulence in a channel flow. We highlight the effects of the modified base flow on the dynamics of velocity fluctuations and net power balance. Our simulations verify the theoretical predictions of Part 1 that the upstream travelling waves promote turbulence even when the uncontrolled flow stays laminar. On the other hand, the downstream travelling waves with parameters selected in Part 1 are capable of reducing the fluctuations' kinetic energy, thereby maintaining the laminar flow. In flows driven by a fixed pressure gradient, a positive net efficiency as large as 25 % relative to the uncontrolled turbulent flow can be achieved with downstream waves. Furthermore, we show that these waves can also relaminarize fully developed turbulent flows at low Reynolds numbers. We conclude that the theory developed in Part 1 for the linearized flow equations with uncertainty has considerable ability to predict full-scale phenomena.
The vanilloid receptor (VR1)‐mediated effects of anandamide are potently enhanced by the cAMP‐dependent protein kinase

The endogenous cannabinoid receptor ligand, anandamide (AEA), is a full agonist of the vanilloid receptor type 1 (VR1) for capsaicin. Here, we demonstrate that the potency and efficacy of AEA at VR1 receptors can be significantly increased by the concomitant activation of protein kinase A (PKA). In human embryonic kidney (HEK) cells over‐expressing human VR1, AEA induces a rise in cytosolic Ca2+ concentration that is mediated by this receptor. The EC50 for this effect was decreased five‐fold in the presence of forskolin (FRSK, 1–5 µm) or the cAMP analogue, 8‐Br‐cAMP (10–100 µm). The effects of 8‐Br‐cAMP and FRSK were blocked by a selective PKA inhibitor. The FRSK (10 nm) also potently enhanced the sensory neurone‐ and VR1‐mediated constriction by AEA of isolated guinea‐pig bronchi, and this effect was abolished by a PKA inhibitor. In rat dorsal root ganglia slices, AEA‐induced release of substance P, an effect mediated by VR1 activation, was enhanced three‐fold by FRSK (10 nm). Thus, the ability of AEA to stimulate sensory VR1, with subsequent neuropeptide release, appears to be regulated by the state of activation of PKA. This observation supports the hypothesis that endogenous AEA might stimulate VR1 under certain pathophysiological conditions.