Miracle-dz/UniFAR-FTUs huggingface dataset:
Brroadband, High Intercept Points, Cost-Effective Power-Efficient Double Balanced Mixer (DBM)

A high intercept points, cost-effective, and power-efficient switching FET double balanced mixer (DBM) is reported. The Switching FET DBM demonstrated in this work offers input intercepts points (IIP3) and conversion loss typically 43 dBm and 9 dB respectively with 16 dBm LO power for the frequency band (RF: 900-2650 MHz, LO: 850-2450 MHz, IF: 50-200 MHz). The measured interport isolation is typically better than 30 dB for broadband applications, and the circuit topology is not limited to these frequencies, and can be easily extended 3rd and later generation of communication systems.
The price risk of options positions: measurement and capital requirements

This article evaluates supervisory approaches to the measurement and capital treatment of the price risk of options positions. The authors find that approximate value-at-risk rules tend to provide better estimates of potential losses than simple strategy-based rules. The value-at-risk rules are particularly effective when they adjust for nonlinear changes in options prices. The authors also consider the reporting burdens posed by the different approaches and the consistency of the rules with existing and proposed supervisory frameworks.
Assessment of Acute Episodes in Chronic Stable Angina: A Clinical-Laboratory Approach to the Use of the Coronary Vasodilator Propatyl Nitrate

Background/Objectives: Propatyl nitrate is a coronary vasodilator with immediate and prolonged action, indicated in the treatment and prevention of acute angina pectoris episodes. Methods: This was an open, self-paired comparative study performed at UNIFESO Medical School evaluating the clinical and laboratory results of treatment with propatyl nitrate in patients with chronic stable angina pectoris. Subjects received 10 mg of propatyl nitrate, at the dose of three sublingual tablets per day, to be taken at 8:00 A.M., 2:00 P.M. , and 8:00 P.M. Subjects returned to the study center after 15 days of treatment for Visit 2 assessments, and at the end of the 30-day treatment period (Visit 3). Results: A total of 200 subjects were included in the study. There was a statistically significant reduction in blood pressure (p < 0.0001) and heart rate (p = 0.0001), but no change in respiratory rate (p = 0.23). Laboratory results did not vary throughout the treatment period. There was no significant change from pretreatment in the SAQ Physical Limitation scale (p = 0.7415). The Angina Stability, Angina Frequency, and Treatment Satisfaction, and Quality of Life scales showed a significant improvement from pretreatment (p < 0.0001). Adverse events were observed among 41 subjects at Visit 2 and 35 subjects at Visit 3. Conclusions: Propatyl nitrate was safe and effective in treating chronic stable angina pectoris over the course of the 30-day treatment period. Treatment with propatyl nitrate increased angina stability and reduced angina frequency while increasing treatment satisfaction and quality of life in the patient population evaluated.
CD117 expression in oesophageal carcinosarcoma: a potential diagnostic pitfall

A 74-year-old man presented to the upper gastrointestinal surgical clinic with a 3-month history of dysphagia and epigastric pain. There had been 3 kg weight loss and his full blood count showed a microcytic, hypochromic anaemia. At endoscopy a polypoid centrally ulcerating lesion was identified arising within 10 mm of the gastro–oesophageal junction. This was suspected of being malignant and biopsies were taken. Subsequent to the biopsy results, a trans-hiatal oesophago-gastrectomy was performed, removing the distal 19 mm of oesophagus.
Reconfigurable Artificial Surfaces Based on Impedance Loaded Wires Close to a Ground Plane

This contribution investigates artificial surfaces based on arrays of impedance loaded wires in the proximity of a ground plane. It is found that for specific loads it is possible to realize high impedance surfaces and absorbing boundaries with very low profile. Furthermore, it is demonstrated that such loads correspond with realistic values which can be implemented with lumped elements and/or magnetic wires. Moreover, a wide bandwidth can be covered by using reconfigurable loads. Finally, bandwidth limitations and robustness of the system against variations in the angle of arrival are analyzed in detail.
Use of ‘Dear Colleague’ Letters in the US House of Representatives: A Study of Internal Communications

‘Dear colleague’ letters – formal, written, member-to-member correspondence – provide a unique window into internal communications in the US House of Representatives. In general, studies of congressional political communications tend to focus on external messaging by members (candidates) to their constituents (voters) through a focus on electoral or constituent communication. Yet these studies may or may not tell us why members choose to engage in internal communication. To address this gap, this paper draws on the literature and presents new hypotheses about factors that increase a member's likelihood of using dear colleague letters. Using House dear colleague letter data from the first session of the 111th Congress (2009), a negative binomial regression tests the importance of seniority, electoral vulnerability, leadership status, and majority party status for dear colleague letter senders. The analysis demonstrates that rank-and-file majority party members who are electorally ‘safe’ are more likely to use the dear colleague system.
TIGER: A software system for fine-mapping quantitative trait loci

The localisation of quantitative trait loci which contribute significantly to phenotype variation of economically important traits in domestic species has become an important goal in animal genomics. Several such loci have been roughly identified using linkage analyses; however the focus has now shifted towards fine mapping and pinpointing causal mutations. In the context of a cooperative national research project, the software system TIGER was developed. TIGER is a UNIX script linking several individual Fortran programmes and is used for comprehensive variance component analysis of fine mapping data. Starting with raw genotype data, pedigree and marker map information and ending with a residual maximum likelihood-based test for each putative quantitative trait locus position, the software provides the user with an ‘all in one’ package capable of linkage analysis, linkage disequilibrium analysis and combined linkage/linkage disequilibrium analysis. The software system has been employed in 4 fine mapping projects on 4 distinct cattle chromosomes.
Targeting OX40 Promotes Lung-Resident Memory CD8 T Cell Populations That Protect against Respiratory Poxvirus Infection

ABSTRACT One goal of vaccination is to promote development of mucosal effector cells that can immediately respond to peripheral infection. This is especially important for protection against viruses that enter the host through the respiratory tract. We show that targeting the OX40 costimulatory receptor (CD134) strongly promotes mucosal memory in the CD8 T cell compartment. Systemic injection of an agonist antibody to OX40 strongly enhanced development of polyfunctional effector CD8 T cells that were induced after intraperitoneal infection with a highly virulent strain of vaccinia virus. These cells were located in lymphoid organs and also the lung, and importantly, long-term memory CD8 T cells were maintained in the lung over 1 year. Anti-OX40 also boosted memory development when mice were vaccinated subcutaneously with viral peptide. These CD8 T cells were sufficient to provide protection from lethal respiratory infection with live vaccinia virus independent of CD4 T cells and antibody. Again, the CD8 T cell populations that were induced after secondary infection displayed polyfunctionality and were maintained in the lung for over a year. These data suggest that agonists to the OX40 costimulatory receptor represent potential candidates for incorporation into vaccines for respiratory viruses.
Reengineering Nonprofit Financial Accountability: Toward a More Reliable Foundation for Regulation

Today, the annual IRS Form 990 tax filing is the principal annual disclosure mechanism of nonprofit organizations. Over time, considerable thought has been put into finding ways to improve access and use of the 990 Form, with only scant attention focused on whether the 990 is the right data source on which to build a system of nonprofit accountability. This paper takes a broader perspective, assessing not only the quality of the financial data and its availability, but also the entire financial reporting model. The paper begins with a framework for thinking about organizational accountability. It then examines the current structure of nonprofit financial reporting and contrasts it with alternative systems developed for publicly traded firms and credit unions. The paper concludes with recommendations for improving nonprofit accountability by reengineering the reporting and oversight systems in the sector.
Speech encryption applying a modified Blowfish algorithm

This paper applied the high quality speech coding algorithm G.729 which has been standardized by ITU-T with low bit rate 8kb/s. This algorithm is based on a conjugate- structure algebraic CELP (CS_ACELP) coding technique with 10ms speech frames. The output of encoder is encrypted by a symmetric key Blowfish algorithm which has 64 bits block size and a variable key length from 32 up to 448 bits. One of the main disadvantages of Blowfish algorithm is the time required to initialize the algorithm with the key. This paper proposes a new method for generating S-boxes and P-arrays which are considered as the main building elements of the Blowfish algorithm. This new generating method leads to a reduction in time complexity of generating S-boxes and P-arrays. The proposed speech encryption system has been implemented using Matlab and the output is analyzed using Avalanche effect. The results showed that the modified design of the algorithm continues to offer the same level of security as the original Blowfish cipher with a less computational overhead in key generation.
The Knowledge Economy and Education and Training in South Asia

How education and training systems respond to the sweeping changes brought about by globalization and the knowledge economy can have far-reaching implications for developing countries in terms of sustainability of growth, competitiveness, job creation, and poverty reduction. This issue is especially pertinent to the countries of South Asia, which are currently growing at a rapid pace and are gradually becoming more integrated into the world economy. This regional study is a first attempt to address these questions. Its main objective is to document and compare trends in education and training in the countries of South Asia, as well as the associated changes in earnings and employment. It draws upon household, labor force, and firm-level surveys from 1990 to the most recent year available. The analysis focuses on Bangladesh, India, Pakistan, and Sri Lanka (countries with well-developed surveys), with some references to Bhutan, the Maldives, and Nepal, along with comparisons with countries in East Asia and with other regions.
CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis1

ABSTRACT The active metabolite of vitamin A, retinoic acid (RA), is known to be essential for spermatogenesis. Changes to RA levels within the seminiferous epithelium can alter the development of male germ cells, including blocking their differentiation completely. Excess RA has been shown to cause germ cell death in both neonatal and adult animals, yet the cells capable of degrading RA within the testis have yet to be investigated. One previous study alluded to a requirement for one of the RA degrading enzymes, CYP26B1, in Sertoli cells but no data exist to determine whether germ cells possess the ability to degrade RA. To bridge this gap, the roles of CYP26A1 and CYP26B1 within the seminiferous epithelium were investigated by creating single and dual conditional knockouts of these enzymes in either Sertoli or germ cells. Analysis of these knockout models revealed that deletion of both Cyp26a1 and Cyp26b1 in either cell type resulted in increased vacuolization within the seminiferous tubules, delayed spermatid release, and an increase in the number of STRA8-positive spermatogonia, but spermatozoa were still produced and the animals were found to be fertile. However, elimination of CYP26B1 activity within both germ and Sertoli cells resulted in severe male subfertility, with a loss of advanced germ cells from the seminiferous epithelium. These data indicate that CYP26 activity within either Sertoli or germ cells is essential for the normal progression of spermatogenesis and that its loss can result in reduced male fertility.
Evidence for glutamatergic tectotectal neurons in the cat superior colliculus: a comparison with GABAergic tectotectal neurons

The tectotectal commissural pathway is commonly regarded as responsible for the reciprocal inhibition that takes place between the two superior colliculi (SC). Although this hypothesis has received strong support from electrophysiological studies, more recent investigations have suggested that some collicular cells, e.g. fixation neurons, may establish excitatory connections with cells in the contralateral SC through the collicular commissure. The goal of the present study was to seek immunohistochemical evidence for glutamatergic tectotectal cells in the cat SC by using a double‐labelling technique. Tectotectal cells were retrogradely labelled with wheat germ agglutinin (WGA) –horseradish peroxidase (HRP) coupled to colloidal gold injected in the contralateral SC, and neurons containing glutamate or γ‐aminobutyric acid (GABA) were then identified with immunohistochemical techniques. The present study provides evidence that, in the cat SC, equal numbers of tectotectal cells are immunopositive to glutamate and GABA, suggesting that the tectotectal pathway may consist of two distinct functional components. The finding that an equal number of tectotectal cells are GABAergic and glutamatergic is somewhat surprising as electrophysiological studies have invariantly indicated that the inhibitory component of the tectotectal projection predominates. Another striking feature of the GABAergic and glutamatergic tectotectal cell populations is their identical topographic distribution in the SC. These results suggest that not only cells in the rostral fixation zone establish excitatory connections with the contralateral SC. Tectotectal projections could be potentially important to shape the spatial pattern of saccade‐related activity that may occur simultaneously in the two SC during vertical and oblique orienting movements.
Chlorpromazine (thorazine) in the treatment of intractable hiccups.

Hiccups may be a minor symptom of transient duration or may progress to exhaust the patient's strength and produce marked depression or even death. Many widely divergent causes for hiccups are known, such as diaphragmatic irritation in pleurisy, subphrenic abscess, or retention of toxic products in uremia. When there is no specific cause, the methods of therapy available are of uncertain value in refractory cases. In the past year, 50 patients with intractable hiccups have been treated with chlorpromazine (Thorazine). This agent is a chlorinated phenothiazine and has the following formula: 10-(γ-dimethylaminopropyl)-2-chlorophenothiazine hydrochloride. The group included 46 men and 4 women from 26 to 80 years of age. Symptoms had persisted from days to weeks and had not responded to heavy sedation, carbon dioxide inhalations, or any other therapy including phrenic nerve crush in five cases (table 1). A dose of 50 mg. was given intravenously. This was sufficient to
Spatial variations in the hidden enterprise culture: Some lessons from England

Despite the growing recognition that many businesses start by trading on a partially or wholly off-the-books basis, there has been little investigation of whether the prevalence and character of this hidden enterprise culture varies spatially. The aim of this paper is to start to fill that gap. Reporting the results of face-to-face interviews conducted in affluent and deprived urban and rural English localities with 91 early-stage entrepreneurs and 81 established self-employed, it is shown that in all localities wholly legitimate businesses are just the tip of the iceberg and that beneath the surface is a large hidden enterprise culture. However, the preponderance of early-stage entrepreneurs and the established self-employed to trade off-the-books is greater in some locality-types than others. Not only do early-stage entrepreneurs and the established self-employed more commonly trade off-the-books in deprived and rural localities, but they are also more likely to trade wholly off-the-books and therefore not be even recognized as existing by official data sources. The implication is that deprived and rural communities are more enterprising and entrepreneurial than is currently recognized and, consequently, that legitimizing this hidden enterprise culture could be an important means of promoting enterprise and economic development in such communities. The paper concludes by briefly reviewing how this might be achieved.
Risk Factors for Arterial Ischemic Stroke in Childhood

Abstract Stroke affects up to 13 of 100,000 children, is more common in boys and African Americans, and is associated with considerable cognitive and psychiatric morbidity, as well as motor disability. Around half are hemorrhagic and half are ischemic. Underlying conditions include sickle cell disease, cardiac abnormalities, chromosomal abnormalities (eg, Down syndrome), and neurocutaneous conditions (eg, neurofibromatosis), but up to half the patients with ischemic stroke have no previously diagnosed condition. Although there is almost certainly an important genetic component to stroke risk, head trauma, infections, drugs and radiation appear to play an etiological role in some patients. The majority of the patients with infarction in an arterial distribution have associated cerebrovascular disease. Vascular pathologies include carotid or vertebrobasilar dissection, intracranial vasculopathy affecting the middle and anterior cerebral arteries, which is often transient, and moyamoya. Intermediate risk factors may include hypertension, hypoxia, and poor nutrition leading, for example, to iron deficiency and hyperhomocysteinemia. Some chronic conditions may directly influence the child's behavior and stroke recurrence risk, although large cohorts and randomized controlled trials will be needed before strategies for modification can be evidence-based.
Accountability towards enabling commercialisation of research in public tertiary education institutions

xv ABBREVIATIONS xviii CHAPTER 1: INTRODUCTION 1 1.1 Background 2 1.2 The Need for and Justification of this Research 4 1.3 Research Questions and Objectives 9 1.4 Structure of this Thesis 11 CHAPTER 2: LITERATURE REVIEW 12 2.
Market Segmentation of Golf Event Spectators Using Leisure Benefits

ABSTRACT The proliferation of golf events has provided increased opportunities to watch professional golf tournaments. The purpose of this study is to examine a variety of leisure benefits sought by Korean golf event spectators and provide useful marketing strategies to fulfill their needs. Within the contexts of leisure benefits, different individuals tend to assign different meanings to the same leisure experience. In this sense, golf event spectators are likely to pursue heterogeneous leisure benefits from their engagement. This study identified four distinct spectator groups (i.e., escape seekers, exercise seekers, interest seekers, and excitement seekers) and uncovered significant differences among these segments. Results provided empirical support that event-based sport tourism marketers need to implement diverse strategies to increase and reinforce their customer base.
Contribution of pilA to Competitive Colonization of the Squid Euprymna scolopes by Vibrio fischeri

ABSTRACT Vibrio fischeri colonizes the squid Euprymna scolopes in a mutualistic symbiosis. Hatchling squid lack these bacterial symbionts, and V. fischeri strains must compete to occupy this privileged niche. We cloned a V. fischeri gene, designated pilA, that contributes to colonization competitiveness and encodes a protein similar to type IV-A pilins. Unlike its closest known relatives, Vibrio cholerae mshA and vcfA, pilA is monocistronic and not clustered with genes associated with pilin export or assembly. Using wild-type strain ES114 as the parent, we generated an in-frame pilA deletion mutant, as well as pilA mutants marked with a kanamycin resistance gene. In mixed inocula, marked mutants were repeatedly outcompeted by ES114 (P < 0.05) but not by an unmarked pilA mutant, for squid colonization. In contrast, the ratio of mutant to ES114 CFUs did not change during 70 generations of coculturing. The competitive defect of pilA mutants ranged from 1.7- to 10-fold and was more pronounced when inocula were within the range estimated for V. fischeri populations in Hawaiian seawater (200 to 2,000 cells/ml) than when higher densities were used. ES114 also outcompeted a pilA mutant by an average of twofold at lower inoculum densities, when only a fraction of the squid became infected, most by only one strain. V. fischeri strain ET101, which was isolated from Euprymna tasmanica and is outcompeted by ES114, lacks pilA; however, 11 other diverse V. fischeri isolates apparently possess pilA. The competitive defect of pilA mutants suggests that cell surface molecules may play important roles in the initiation of beneficial symbioses in which animals must acquire symbionts from a mixed community of environmental bacteria.
Prophylactic or Early Selective Surfactant Combined With nCPAP in Very Preterm Infants

OBJECTIVE: Early surfactant followed by extubation to nasal continuous positive airway pressure (nCPAP) compared with later surfactant and mechanical ventilation (MV) reduce the need for MV, air leaks, and bronchopulmonary dysplasia. This randomized, controlled trial investigated whether prophylactic surfactant followed by nCPAP compared with early nCPAP application with early selective surfactant would reduce the need for MV in the first 5 days of life. METHODS: A total of 208 inborn infants who were born at 25 to 28 weeks' gestation and were not intubated at birth were randomly assigned to prophylactic surfactant or nCPAP within 30 minutes of birth. Outcomes were assessed within the first 5 days of life and until death or discharge of the infants from hospital. RESULTS: Thirty-three (31.4%) infants in the prophylactic surfactant group needed MV in the first 5 days of life compared with 34 (33.0%) in the nCPAP group (risk ratio: 0.95 [95% confidence interval: 0.64–1.41]; P = .80). Death and type of survival at 28 days of life and 36 weeks' postmenstrual age and incidence of main morbidities of prematurity (secondary outcomes) were similar in the 2 groups. A total of 78.1% of infants in the prophylactic surfactant group and 78.6% in the nCPAP group survived in room air at 36 weeks' postmenstrual age. CONCLUSIONS: Prophylactic surfactant was not superior to nCPAP and early selective surfactant in decreasing the need for MV in the first 5 days of life and the incidence of main morbidities of prematurity in spontaneously breathing very preterm infants on nCPAP.