Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro.

Small unilamellar neutral, negatively and positively charged liposomes composed of egg phosphatidylcholine, various amounts of cholesterol and, when appropriate, phosphatidic acid or stearylamine and containing 6-carboxyfluorescein were injected into mice, incubated with mouse whole blood, plasma or serum or stored at 4 degrees C. Liposomal stability, i.e. the extent to which 6-carboxyfluorescein is retained by liposomes, was dependent on their cholesterol content. (1) Cholesterol-rich (egg phosphatidylcholine/cholesterol, 7:7 molar ratio) liposomes, regardless of surface charge, remained stable in the blood of intravenously injected animals for up to at least 400min. In addition, stability of cholesterol-rich liposomes was largely maintained in vitro in the presence of whole blood, plasma or serum for at least 90min. (2) Cholesterol-poor (egg phosphatidylcholine/cholesterol, 7:2 molar ratio) or cholesterol-free (egg phosphatidylcholine) liposomes lost very rapidly (at most within 2min) much of their stability after intravenous injection or upon contact with whole blood, plasma or serum. Whole blood and to some extent plasma were less detrimental to stability than was serum. (3) After intraperitoneal injection, neutral cholesterol-rich liposomes survived in the peritoneal cavity to enter the blood circulation in their intact form. Liposomes injected intramuscularly also entered the circulation, although with somewhat diminished stability. (4) Stability of neutral and negatively charged cholesterol-rich liposomes stored at 4 degrees C was maintained for several days, and by 53 days it had declined only moderately. Stored liposomes retained their unilamellar structure and their ability to remain stable in the blood after intravenous injection. (5) Control of liposomal stability by adjusting their cholesterol content may help in the design of liposomes for effective use in biological systems in vivo and in vitro.
Position and attitude feedback controller of a planar satellite with two thrusters

This paper proposes a feedback control method for the in-plane motion of a satellite equipped with two thrusters, whose force directions are fixed to the satellite. The satellite's equations of motion have second-order nonholonomic constraints. This paper utilizes an invariant manifold and develops a feedback controller based on the Lyapunov's second method. The developed controller can control the satellite's state composed of six components for the position and attitude angle by two thruster systems. Furthermore, the controller has robustness for the system's modeling errors. Some simulations results are shown to demonstrate the effectiveness of the developed controller.
Incremental re-execution of programs

Interpreters replace the edit/compile/run cyle with edit/run. Dynamic computing environments, like spreadsheets, shorten this still more to just edit. So-called "Visiprog" environments, such as Maryland's XED, permit developing normal imperative programs in a dynamic computing environment, XED and similar environments, because they show the results of executing a program after every (reasonable) editing step, raise the issue of efficient incremental execution. Incremental execution optimizations are also applicable to any programming situation, including batch/cards, in which nearly the same program is run many times on nearly the same data. However, the requirement of remembering large amounts of internal state between runs make incremental exectution most natural for interpreted languages. This paper examines some algorithms for incremental execution. Based on the frequency of typical program editing changes, we predict the importance of optimizing certain kinds of incremental execution. We also examine actual speedups obtained in executing programs after subjecting them to these simulated incremental edits under these optimizations. The speedups range from factors of 1.1 to near 10. Finally, we discuss the feasibility of including these optimizations in an actual dynamic computing environment like XED, and in more traditional programming environments.
The state of critical thinking today

Research demonstrates that most college faculty lack a substantive concept of critical thinking, though they mistakenly think otherwise. This chapter spells out the implications of such a robust concept and emphasizes that success in bringing a substantive concept of critical thinking to college faculty requires well-planned, long-term professional development based explicitly on the multiple dimensions of a substantive concept of critical thinking.
Extracting Ontological Knowledge from Textual Descriptions through Grammar-based Transformation

In this paper, we propose a new CNL called tedei (TExtual DEscription Identifier) whose grammar is inspired by the different ways in which OWL-DL constructs are expressed in English. We built a system that transforms Tedei sentences into corresponding OWL-DL axioms. Now, ambiguity due to different possible lexicalizations of sentences and semantic ambiguity present in sentences are challenges in this context. We find that the best way to handle these challenges is to construct axioms corresponding to alternative formalizations of the sentence so that the end-user can make an appropriate choice. The output is compared against human-authored axioms and in substantial number of cases, human-authored axiom is indeed one of the alternatives given by the system. The proposed system substantially enhances the types of sentence structures that can be used for ontology authoring.
Whole-body leucine and lysine metabolism: response to dietary protein intake in young men.

Whole-body leucine and lysine metabolism was explored in young adult men by a primed constant intravenous infusion of a mixture of L-[1-13C]leucine and L-[alpha-15N]lysine over a 4-h period. Subjects were studied after an overnight fast (postabsorptive state) or while consuming hourly meals (fed state) after adaptation to diets providing either a surfeit level of protein (1.5 g.kg body-1.day-1), a level approximating maintenance requirements (marginal intake) (0.6 g.kg body wt-1.day-1), or a grossly inadequate level (0.1 g.kg-1.day-1). The change in protein intake from a marginal to a surfeit level was associated with an increased leucine flux and incorporation of leucine into body protein. In the fed state, oxidation of leucine increased sharply and release of leucine from tissue protein diminished. When dietary protein intake was reduced from the requirement to inadequate level, leucine flux and body protein synthesis and protein breakdown were reduced, together with a smaller reduction in leucine oxidation. The response of the metabolism of [15N]lysine was responsible for maintenance of leucine and other essential amino acid economy, and they appear to be related to the nitrogen and amino acid requirements of the subject. These findings also demonstrate an effect of meals, modulated by their protein content, on the dynamics of whole-body amino acid metabolism.
Issues in designing learning by teaching systems

Learning by teaching systems are a relatively recent approach to designing Intelligent Learning Environments that place learners in the role of tutors. These systems are based on the practice of peer tutoring where students take on defined roles of tutor and tutee. An architecture for learning by teaching systems is described that does not require the domain model of an Intelligent Tutoring System. However a mutual communication language is needed and is defined by a conceptual syntax that delimits the domain content of the dialogue. An example learning by teaching system is described for the domain of qualitative economics. The construction and testing of this system inform a discussion of the major design issues involved: the nature of the learnt model, the form of the conceptual syntax, the control of the interaction and the possible introduction of domain knowledge.
Maple Syrup Urine Disease (MSUD): A Case with Long-Term Follow-up after Liver Transplantation

Maple syrup urine disease (MSUD) is a rare hereditary metabolic condition where the body is unable to breakdown amino acids causing toxic buildup. Acute and long-term management of MSUD involves a restricted diet and regular monitoring of amino acid levels; however, more recently liver transplants have been shown to be successful in treating this condition. Even with successful management of MSUD there is evidence from pediatric cases that shows a distinct pattern of neurocognitive deficits associated with this condition, including impaired nonverbal skills and psychomotor functioning with relatively intact verbal abilities. In the present paper, we report an adult case of MSUD with associated neurocognitive deficits and functional limitations following liver transplantation. Neuroimaging revealed no structural abnormalities, while the results from the neuropsychological evaluation showed impairment in visual-spatial processing, attention, executive functioning, and psychomotor abilities, with relative strengths in verbal skills. The patient also showed reduced adaptive functioning and mild anxiety. This case demonstrates neurocognitive deficiencies within the context of normal magnetic resonance imaging. The possible underlying mechanism of this neuropsychological profile is discussed in relation to other neurodevelopmental models.
Improve the Evaluation of Fluency Using Entropy for Machine Translation Evaluation Metrics

The widely-used automatic evaluation metrics cannot adequately reflect the fluency of the translations. The n-gram-based metrics, like BLEU, limit the maximum length of matched fragments to n and cannot catch the matched fragments longer than n, so they can only reflect the fluency indirectly. METEOR, which is not limited by n-gram, uses the number of matched chunks but it does not consider the length of each chunk. In this paper, we propose an entropy-based method, which can sufficiently reflect the fluency of translations through the distribution of matched words. This method can easily combine with the widely-used automatic evaluation metrics to improve the evaluation of fluency. Experiments show that the correlations of BLEU and METEOR are improved on sentence level after combining with the entropy-based method on WMT 2010 and WMT 2012.
The baryonic asymmetry of the Universe

We discuss a possible process of appearance of an excess of baryons and antileptons during the early stage of expansion of a charge-symmetric hot universe in the framework of a unified gauge theory of strong, weak, and electromagnetic interactions. According to the estimates of the present paper, the baryon asymmetry A = NB/N, (the ratio of the mean baryon density to the density of quanta of the background radiation, which, up to a numerical factor, equals the ratio of the number of baryons to the initial entropy of the hot universe in the same comoving volume element) has the order of magnitude A -a36'6, (a = g2 is the coupling constant of the gauge field, 8 is a quantity of the order of the Cabibbo angle, 6, is the phase of the complex quark mixing). The numerical coefficient in this formula may contain an additional small parameter. The paper presents some arguments relative to the "multifoliated" (manysheeted) model of the universe previously proposed by the author.
Hepatitis B virus sub-genotype A1 infection is characterized by high replication levels and rapid emergence of drug resistance in HIV-positive adults receiving first-line antiretroviral therapy in Malawi.

BACKGROUND It has been proposed that hepatitis B virus (HBV) sub-genotype A1 infections have mild outcomes and a low risk of drug-resistance among patients infected with human immunodeficiency virus (HIV) receiving lamivudine-containing antiretroviral therapy (ART) without tenofovir in Africa. METHODS The virologic expression of HBV sub-genotype A1 coinfection was studied over 12 months in HIV-positive adults starting stavudine/lamivudine/nevirapine in Malawi, using Sanger, deep, clonal, and single full-genome sequencing for the sensitive characterization of HBV resistance-associated mutations (RAMs). RESULTS Among 1117 subjects, 133 (12%) tested HBsAg-positive. After starting ART, retention rates were 96/133 (72%) at 6 months and 54/133 (41%) at 12 months. Based upon the last available follow-up, 92/96 (96%) subjects achieved HIV-1 RNA <40 copies/mL, 48/96 (50%) showed HBV DNA <14 IU/mL, and 24/96 (25%) acquired HBV RAMs. At 6 months, M204I was detected in 8/46 (17%) and 16/17 (94%) subjects using Sanger and deep sequencing, respectively. At 12 months, all viremic patients had multiple resistance and compensatory mutations coexisting on the same HBV genomes. Comparing HBeA-positive (67/133, 50%) with HBeAg-negative subjects, 64/67 (96%) vs 35/66 (55%) showed baseline HBV DNA >2000 IU/mL (P = .0006), 39/47 (17%) vs 9/49 (82%) had persistent HBV DNA detection during follow-up (P < .0001), and 23/47 (49%) vs 2/49 (4%) acquired HBV RAMs (P < .0001). Baseline HBV DNA levels were median 8.1 vs 5.3 log10 IU/mL in subjects with vs those without treatment-emergent RAMs (P < .0001). CONCLUSIONS HBV sub-genotype A1 infections showed a severe virologic expression in HIV-positive Malawians. The findings strengthen the urgency of interventions to improve ascertainment and management of chronic hepatitis B in the region.
The effect of a model melanoidin mixture on faecal bacterial populations in vitro

The Maillard reaction produces coloured, macromolecular materials (melanoidins) in a variety of foods, on heating. Significant quantities may enter the human gut on a daily basis, but there is little information on their metabolism in the human colon. As the large bowel contains a diverse population of bacteria involved in normal bowel function, it is possible that melanoidins are metabolized therein. Depending on the bacteria involved, there may be disease or health implications. The aim of the present study was to use in vitro models to determine the digestibility of melanoidins and the effect of melanoidins on colonic bacteria in the gastrointestinal tract. Melanoidins were prepared and the effects of simulated upper-gut secretions on their stability determined in a model system. The effects of faecal bacteria were also determined, in batch culture, with a combination of phenotypic and genotypic (probes) criteria being used to identify the microbial diversity involved. Simulation of peptic and pancreatic digestion showed that the melanoidins did not produce detectable amounts of low-molecular-mass degradation products. However, melanoidins affected the growth of gut bacteria during mixed culture growth. The effect was to cause a non-specific increase in the anaerobic bacteria enumerated. This in vitro study indicates that melanoidins can affect the growth of human large-bowel bacteria and serves to demonstrate possible effects that may occur in vivo. Given the large and varied number of food items that contain Maillard reaction products, this may have relevance for lower-gut health.
Comparison of 30 mCi and 50 mCi I-131 doses for ablation of thyroid remnant in papillary thyroid cancer patients

ABSTRACT Purpose of the study: To compare efficacy of thyroid remnant ablation using 30 mCi or 50 mCi 131-I in papillary thyroid cancer patients. Materials and methods: Five hundred and fifteen consecutive patients with Tumor-Node-Metastasis (TNM) stages T1-T3 N1/N0/NX receiving either 30 mCi or 50 mCi I-131 were analyzed for the effectiveness of remnant ablation using rhTSH-stimulated serum thyroglobulin. One hundred and five consecutive patients receiving 100 mCi I-131 were analyzed for the incidence of radiation thyroiditis and sialadenitis. Results and conclusions: Doses of 30 mCi and 50 mCi were equally effective for low- and moderate-risk disease but 30 mCi was less effective for T1T2NX disease, and 50 mCi was less effective for T3 compared to T1T2 disease. Low dose radiation hypersensitivity or unknown more extensive disease may have accounted for observed differences. Radiation thyroiditis and sialadenitis were more common in a comparison series of 100 mCi dose compared to 30 mCi, but not more common than in 50 mCi doses.
Motion Trajectory of Players using Optical Flow

This paper gives a brief idea of the moving objects tracking and its application. In sport it is challenging to track and detect motion of players in video frames. Task represents optical flow analysis to do motion detection and particle filter to track players and taking consideration of regions with movement of players in sports video. Optical flow vector calculation gives motion of players in video frame. This paper presents improved Luacs Kanade algorithm explained for optical flow computation for large displacement and more accuracy in motion estimation.
Evolutionary many-objective optimization: A short review

Whereas evolutionary multiobjective optimization (EMO) algorithms have successfully been used in a wide range of real-world application tasks, difficulties in their scalability to many-objective problems have also been reported. In this paper, first we demonstrate those difficulties through computational experiments. Then we review some approaches proposed in the literature for the scalability improvement of EMO algorithms. Finally we suggest future research directions in evolutionary many-objective optimization.
Neural activity associated with attention orienting triggered by gaze cues: A study of lateralized ERPs

This study investigated the electrophysiological (event-related potential, ERP) and behavioral (reaction time, RT) correlates of gaze-cued shifts of visuospatial attention. Participants viewed centrally presented faces with neutral expressions in which eyes looked straight ahead and then shifted to the left or right. Upon movement of the eyes, the facial expression either stayed the same (neutral) or changed to a fearful or happy expression. Participants' task was to identify a probe letter (T or L), which appeared in either the same or the opposite location to the direction of the eye gaze. There was behavioral evidence of a gaze congruency effect, as RTs were faster when the eyes looked toward rather than away from the location of the target. The ERP data indicated the presence of a significant gaze-congruent anterior directing attention negativity (ADAN) at anterior locations (300–500 ms after the onset of the gaze cue). ERP data did not show evidence of initial orienting of attention triggered by gaze cues in the early directing attention negativity (EDAN) at posterior locations (200–300 ms post-cue onset). The gaze cueing effects in the RT and ERP data were not significantly influenced by the emotional expression of the faces. The presence of the ADAN may reflect neural mechanisms that underlie the holding of attention on gazed-at locations.
Large-Scale Fabrication of Ordered Silicon Nanotip Arrays Used for Gas Ionization in Ion Mobility Spectrometers

The 9/11 events have led to an increase in the request for sensors and sensor systems that can detect rapidly, efficiently, and at moderate cost trace explosives and a whole range of toxic substances at diverse control points, e.g., at airports and inside air conditioning systems in aircraft and public buildings. To date, the security screening instruments of choice are ion mobility spectrometers (IMS), which are basically time-of-flight mass spectrometers (Sielemann, 1999 and Stach, 1997). Such instruments allow for the detection of explosives, chemical warfare agents, and illicit drugs. Widespread adoption of the IMS technology in civilian security screening applications, for instance, at airports, has been hindered due to the fact that state-of-the-art spectrometers employ radioactive ion sources. We report on fabrication and measurements of large-scale-ordered silicon nanotip arrays, used to replace the radioactive source for IMS gas ionization. Surface ionization mechanisms on the platinum-coated silicon surface can be significantly increased compared to flat structures due to the strong field enhancement at the tips. We will show measurements of the ion current of planar surfaces compared to microstructured surfaces as well as a photoelectrochemical etching process that allows to etch flat tips with a low aspect ratio as well as long tips with high aspect ratios with exact control about the tip profile.
Learning Domain-specific Sentiment Lexicon with Supervised Sentiment-aware LDA

Analyzing and understanding people's sentiments towards different topics has become an interesting task due to the explosion of opinion-rich resources. In most sentiment analysis applications, sentiment lexicons play a crucial role, to be used as metadata of sentiment polarity. However, most previous works focus on discovering general-purpose sentiment lexicons. They cannot capture domain-specific sentiment words, or implicit and connotative sentiment words that are seemingly objective. In this paper, we propose a supervised sentiment-aware LDA model (ssLDA). The model uses a minimal set of domain-independent seed words and document labels to discover a domain-specific lexicon, learning a lexicon much richer and adaptive to the sentiment of specific document. Experiments on two publicly-available datasets (movie reviews and Obama-McCain debate dataset) show that our model is effective in constructing a comprehensive and high-quality domain-specific sentiment lexicon. Furthermore, the resulting lexicon significantly improves the performance of sentiment classification tasks.
ResearchGate: Disseminating, communicating, and measuring Scholarship?

ResearchGate is a social network site for academics to create their own profiles, list their publications, and interact with each other. Like Academia.edu, it provides a new way for scholars to disseminate their work and hence potentially changes the dynamics of informal scholarly communication. This article assesses whether ResearchGate usage and publication data broadly reflect existing academic hierarchies and whether individual countries are set to benefit or lose out from the site. The results show that rankings based on ResearchGate statistics correlate moderately well with other rankings of academic institutions, suggesting that ResearchGate use broadly reflects the traditional distribution of academic capital. Moreover, while Brazil, India, and some other countries seem to be disproportionately taking advantage of ResearchGate, academics in China, South Korea, and Russia may be missing opportunities to use ResearchGate to maximize the academic impact of their publications.
Dystonia and DBS: The Jury Arrives

Even before the deep brain stimulation (DBS) era, stereotactic functional neurosurgery such as thalamotomy and pallidotomy had been used for control of medically intractable dystonia (Cooper, 1976; Lozano et al., 1997). However, unreliability and variability in the results and furthermore, needs for bilateral surgery in most patients with generalized dystonia and the occurrence of unacceptable adverse effects including dysarthria and cognitive impairment have greatly limited their use. In this regard, DBS, which provides a more stable response with fewer side effects, has revolutionized the treatment of dystonia. The first report of DBS for dystonia was by Mundinger in 1977 (Mundinger, 1997). Since then, over the past few decades, bilateral globus pallidus internus (GPi) DBS has emerged as the best therapeutic option for medication-refractory dystonia (Lang, 2011).