Miracle-dz/UniFAR-FTUs huggingface dataset:
Searching for Key Genes in Ulcerative Colitis: a Bioinformatics Study

Objective: The incidence of ulcerative colitis (UC) is increasing year by year, which leads to increasing cost of medical resources investment, and the exact pathogenesis of the disease is still unclear, leading to difficulties in clinical diagnosis and treatment. This study is based on a bioinformatics approach to search for possible key genes leading to the development of this disease, hoping to provide clinicians with new biomarkers that can be used for reference, so that patients can receive timely diagnosis and treatment.Methods: Peripheral blood-related information was first obtained from the Gene Expression Omnibus (GEO) database for UC patients and non-UC populations. Then differentially expressed genes were identified using R language (based on "Limma" software). Functional enrichment analysis was then performed, followed by screening of central genes, and finally correlations between the central genes were investigated using Spearman correlation analysis.Results: Fifty-nine up-regulated and 39 down-regulated DEGs were screened. These genes were involved in pathways such as viral protein-cytokine receptor interaction, cytokine-cytokine receptor interaction, biosynthesis of pantothenic acid and coenzyme A, IL-17 signaling pathway and chemokine signaling pathway. And growth regulatory alpha protein, C-X-C chemokine receptor 1, C-C patterned chemokine 2, and trigger receptor 1 expressed in bone marrow cells were found to be the top ten hub genes. The final correlation analysis showed a positive correlation between these ten hub genes.Conclusion The present study identified 10 DEGs as possible biomarkers for the diagnosis of patients with ulcerative colitis. Experiments are needed to validate the present study.
Brownian motion of a single microscopic sphere in a colloidal force field

Total internal reflection microscopy has been used to monitor the submicroscopic distance separating a microscopic sphere and a transparent plate. Light scattered from an evanescent wave by a single sphere is exponentially sensitive to the elevation of the sphere above the plate. Changes in separation as small as 1 nm are detectable. The technique is virtually instantaneous, non-intrusive, and easily automated. Two applications are discussed: from an equilibrium distribution of separations, a direct measure of the mean potential of surface forces acting on the sphere can be obtained; from an autocorrelation of the separation as a function of time, the sphere's diffusion coefficient, D, can be obtained. Forces as small as 10–13 N can be accurately measured. Owing to its close proximity to the wall, a 10 µm polystyrene sphere in 0.5 mmol dm–3 NaCl has a value of D of ca. 2% of the bulk value. The fractional reduction in D suggests that the sphere resides ca. 100 nm above the glass plate.
Franz–Keldysh effect in lateral GaAs/AlGaAs based npn structures

Lateral npn structures, fabricated by focused laser beam-induced doping, combine large potential modulations with a small width of the p-doped regions. This results in strong lateral electric fields, which can be tuned by applying a bias voltage. Photon absorption for energies below the band gap is allowed due to the Franz–Keldysh effect. We estimate the value of the electric fields by analyzing wavelength-dependent photocurrent measurements. The fields are comparable to attainable fields in existing vertical modulator structures. The spatially resolved photocurrent measurements reveal the location of the highest lateral electric field, which is at the edges of the p-doped region.
Blocker-Tolerant Inductor-Less Harmonic Selection Wideband Receiver Front-End for 5G Applications

A blocker-tolerant harmonic selection receiver front-end with RF bandwidth of 6.5 GHz to support the fifth-generation (5G) sub-6 GHz band is presented. The proposed N-path switching filter-based receiver employs harmonic recombination blocks at the baseband (BB) to select the desired local oscillator (LO) harmonics and suppress blockers. It is demonstrated how the configuration of two feed-forward N-path switching filters and BB harmonic recombination stage can be reconfigured to select the first harmonic of the switching frequency at the low-frequency band (0.5–1.9 GHz) and the third LO harmonic at the high-frequency band (1.95–6 GHz). Thus, the proposed architecture has the capability of supporting an RF input frequency of up to 6 GHz while the switching frequency operates up to 2 GHz. Higher harmonic selection in addition to the fundamental helps to reduce the power consumption and required input frequency of the multiphase LO clock generator. An RF receiver prototype is fabricated in a TSMC 130-nm CMOS technology. It achieves a 5 dB noise figure (NF), −16.6 dBm in-band input-referred third-order intercept point (IIP3), and 9 dBm out-of-band (OOB) IIP3, respectively, at the low-frequency band (0.5–1.9 GHz). The 2nd–5th harmonic rejection ratios (HRRs) are higher than 44 dB without any calibration. The receiver can tolerate a 0 dBm blocker at a 180 MHz offset from a 1 GHz switching frequency with an NF of 9.4 dB. Over the high-frequency band (1.95–6 GHz), the receiver’s NF is less than 7.1 dB. Moreover, in-band IIP3, OOB IIP3, and first HRR are higher than −21 dBm, 7 dBm, and 39 dB, respectively. The receiver achieves an S11 better than −10 dB over 0.5–6 GHz, and has a total power consumption of 17–22.5 mW from a 1.2 V supply.
Compound Interdependences in MOP

We consider multiple objective programming (MOP) problems with compound interdependences, i.e. the case when the states of some chosen objective are attained through supportive or inhibitory feed-backs from several other objectives. MOP problems with independent objectives (i.e. when the cause-effect relations between the decision variables and the objectives are completely known) will be treated as special cases of the MOP in which we have interdependent objectives.
Traveling wave speeds in rapidly oscillating media

In this paper we study the effects of periodically varying heterogeneous media on the speed of traveling waves in reaction-diffusion equations. Under suitable conditions the traveling wave speed of the non-homogenized problem can be calculated in terms of the speed of the homogenized problem. We discuss a variety of examples and focus especially on the influence of the symmetric and antisymmetric part of the diffusion matrix on the wave speed.
Convergence of Fourier methods for the Navier-Stokes equations

Optimal orders of convergence for the Fourier-Galerkin method for two-dimensional Navier–Stokes equations in various energy norms and in $L^p$-norm of the velocity field are proved. Optimal orders of convergence for the Fourier-collocation method are also proved. Extensions of these results to three-dimensional Navier–Stokes equations in the original form and the rotational form are presented. Semigroup formulations and the variation of constants formula are the essential tools in the analysis.
Detection of Quiescent Molecular Hydrogen Gas in the Circumstellar Disk of a Classical T Tauri Star

We have detected emission from the quiescent, molecular hydrogen gas in the disk around the X-ray bright, classical T Tauri star TW Hya in the 1-0 S(1) line at 2.1218 μm through high-resolution spectroscopy using CSHELL on NASA's Infrared Telescope Facility. The brightness of the observed emission line is consistent with that predicted from models for X-ray excitation of the 1-0 S(1) line of H2. This result demonstrates that X-ray ionization is a plausible mechanism for excitation of the H2 in the gaseous disks of T Tauri stars. In addition, from these high-resolution spectra we have measured the radial velocities of three T Tauri stars in the TW Hya association, CD -33°7795, HD 98800, and TW Hya. We find that the radial velocities of these three stars are very similar to each other and to those of at least three other stars presumed to be members of the TW Hya association, Hen 600A, Hen 600B, and CD -29°8887. This result, combined with the similar proper motions of all six of these stars, lends support to the hypothesis that all of these stars share a common origin in a now-dispersed molecular cloud.
Evidence for Matthiessen's rule in the normal state resistivity of zinc doped yttrium barium copper oxide

The authors have measured the electrical resistivity rho (T) for a number of sintered samples of Y1Ba2(Cu1-xZnx)3O7 with x in the range 0.01-0.10. Above Tc, d rho /dT falls smoothly with increasing bulk density and is independent of x as confirmed by measurements on alloys of equal density. Taking d rho /dT to be independent of x, they find that the extrapolated residual resistivity ( rho res) at T=O increases linearly with x in the range O<or=x<or=0.07. These facts suggest that the linear term in rho arises from an intrinsic scattering mechanism which is independent of x, and that the substituting zinc atoms act as independent scattering centres, in accordance with Matthiessen's rule for normal metals.
Effects of Atmospheric Absorption of Incoming Radiation on the Radiation Limit of the Troposphere

AbstractThe limit of the planetary radiation (longwave radiation) of a planet with oceans on its surface is determined by various mechanisms called “radiation limits,” which can be classified as the Komabayashi–Ingersoll limit and the radiation limit of the troposphere. The effects of atmospheric absorption of the incoming central star radiation (shortwave radiation) on the radiation limit of the troposphere are investigated. To clarify the effects, simple parameterization of the absorption is performed. Two cases are found using an atmospheric model without a window for the longwave radiation. When the absorption in the upper atmosphere is effective, the radiation limit becomes larger than in the no-absorption case. On the other hand, the radiation limit disappears in the absence of a window for the incoming radiation.
Patterns of relational aggression, narcissism, and self-esteem: Adolescents’ social goals unraveled

This study applies latent profile analysis to identify profiles of adolescents differentiated on levels of relational aggression (RAgg), self-esteem, and narcissism. To understand the social aspects of these profiles within the adolescent peer context, we compare them to their reported social goals of dominance, popularity, and intimacy. Greek junior high school students (N = 2,207), selected via random stratified cluster sampling, aged 13–16 (M = 14.04, SD =.81), completed a self-report survey. Based on self-esteem, narcissism, and RAgg scores, four groups emerged: the group with the lowest scores in RAgg, narcissism, and self-esteem (“low risk”), the group with the highest scores in RAgg, narcissism, and self-esteem (“relational aggressors with narcissistic self-esteem”), the group with moderate scores in RAgg, narcissism, and self-esteem (“moderate risk”), and the group with high RAgg and narcissism scores but low self-esteem (“relational aggressors with vulnerable self-esteem”). Relational aggressors with high narcissism and self-esteem scored higher on social goals than those with vulnerable self-esteem (high narcissism but low self-esteem). Preventive policies should replace excessive and unconditional praise with more realistic self-esteem sources and teach adolescents how to respond to negative feedback and to cope with ego threats or social placement concerns.
Multiple Scattering of X-Rays and Neutrons. III. A Study of the Sensitivity of the Multiple Scattering Method to Measure Lattice Constants

a) The conditions to attain high sensitivity and precision in the measurement of the ratio γ of the wavelength to the cubic crystal parameter a, by the multiple scattering method are discussed. b) The width of the interaction peaks and a relationship between the peak width and the uncertainty in γ, are obtained theoretically. c) The formulas thus obtained are analyzed in an attempt to optimize the experiment. d) From this study, the possibility arises of performing “divergence-free" experiments, where the contributions of the beam divergence and of mosaic spread to the width of the peak, and then to the uncertainty in γ, cancel out. A comparison between experimental values and those predicted by the theory shows a reasonably good agreement which can be considered as an initial confirmation of the theory.
On the Transience of Circumstellar Shells about |b| ≥ 10° OH/IR Stars. I. Basic Statistics

There are 62 OH/IR stars in the Arecibo sky with |b| ≥ 10°, |l| < 90°, and a 25 μm flux S(25) ≥ 2 Jy. These were identified as a result of a complete OH survey of color-selected IRAS sources, which also identified four O-rich proto-planetary nebulae (PPNs). Since OH/IR stars evolve into PPNs, the ~103 yr expansion age of one, 18095+2704, calibrates an ~1670 yr average net duration for 1612 MHz emission from high-latitude stars. This is comparable with the 770 yr wind travel time from the photosphere out to the 1612 MHz emission zone of WX Psc and the ~500 yr duration of the luminosity spike following after a thermal pulse. There is, however, only one PPN candidate without an OH maser to match to the sample's 118 OH/IR-star color mimics (circumstellar shells with the IR colors of OH/IR stars that do not exhibit 1612 MHz masers), where eight are implied if mimics independently evolve through a PPN phase. Most mimics are therefore likely to be the immediate precursors of OH/IR stars. The average net duration of heavy mass loss in a superwind is then estimated from the ratio between the number of IR sources and PPNs at ~3700 yr. However, the absence of any O-rich PPNs to match to OH/IR stars and mimics in the Galactic anticenter region (AGC), even though there are two carbon stars and four C-rich PPN with appropriate IR colors there, offers a strong hint that most OH/IR stars in the AGC exit their asymptotic giant branch phase as C-rich PPNs. This carries the direct implication that the superwind phase in high-latitude stars is usually a cyclical phase.
Robust Classification Model for Diabetic Retinopathy Based on the Contrastive Learning Method with a Convolutional Neural Network

Diabetic retinopathy is one of the most common microvascular complications of diabetes. Early detection and treatment can effectively reduce the risk. Hence, a robust computer-aided diagnosis model is important. Based on the labeled fundus images, we build a binary classification model based on ResNet-18 and transfer learning and, more importantly, improve the robustness of the model through supervised contrastive learning. The model is tested with different learning rates and data augmentation methods. The standard deviations of the multiple test results decrease from 4.11 to 0.15 for different learning rates and from 1.53 to 0.18 for different data augmentation methods. In addition, the supervised contrastive learning method also improves the average accuracy of the model, which increases from 80.7% to 86.5%.
Symmetry-general least-squares extraction of elastic data for strained materials from ab initio calculations of stress

A symmetry-general approach for the least-squares, therefore precise, extraction of elastic coefficients for strained materials is reported. It analyzes stresses calculated ab initio for properly selected strains. The problem, its implementation, and its solution strategy all differ radically from a previous energy-strain approach that we published last year, but the normal equations turn out to be amenable to the same constrainment scheme that makes both approaches symmetry general. The symmetry considerations governing the automated selection of appropriately strained models and their Cartesian systems are detailed. The extension to materials under general stress is discussed and implemented. VASP was used for ab initio calculation of stresses. A comprehensive range of examples includes a triclinic material (kyanite) and simple materials with a range of symmetries at zero pressure, MgO under hydrostatic pressure, ${\mathrm{Ti}}_{4}{\mathrm{As}}_{3}$ under [001] uniaxial strain, and Si under [001] uniaxial stress. The MgO case agrees with recent experimental work including elastic coefficients as well as their first and second derivatives. The curves of elastic coefficients for Si show a gradual increase in the 33 compliance coefficient, leading to a collapse of the material at -11.7 GPa, compared with -12.0 GPa experimentally. Interpretation of results for Be using two approximations [local density (LDA), generalized gradient (GGA)], two approaches (stress strain and energy strain), two potential types (projector augmented wave and ultrasoft), and two quantum engines (VASP and ORESTES) expose the utmost importance of the cell data used for the elastic calculations and the lesser importance of the other factors. For stiffness at relaxed cell data, differences are shown to originate mostly in the considerable overestimation of the residual compressive stresses at x-ray cell data by LDA, resulting in a smaller relaxed cell, thus larger values for diagonal stiffness coefficients. The symmetry generality of the approach described here enabled the creation of a robust user interface going seamlessly from the database search to the printout of the elastic coefficients. With it, even nonspecialist users can reliably produce technologically relevant results like those discussed here in a simple point-and-click fashion from corresponding entries in the CRYSTMET\textregistered{} and ICSD\textregistered{} structure databases, i.e., for all pure-phase nonorganic materials with known crystal structure. The case of ${\mathrm{Ti}}_{4}{\mathrm{As}}_{3}$ exposes, on a first cluster of properties, stiffness, compliance, and the isotropic properties that can be derived from them, the current reality of mining crystal structure databases with ab initio software for technological properties that were never measured before. Further developments in that direction are currently underway.
Control of the defect in the liquid crystal director field on the slit of the patterned vertical alignment cell

In this letter the authors studied the method to control the position of the generated defect on the slit of the patterned vertical alignment liquid crystal (LC) cell with dynamic stability. The authors modeled the LC director field with a defect on the slit and proposed an advanced wing pattern with a defect trap to stick the defect outside the active area. This shape can prevent the generation of the defect on the slit in the active area even if the authors increase the operation voltage, so that the LC dynamics on the slit is very stable and optical transmittance becomes higher.
The Impact of Financial Development on Renewable Energy Consumption: A Multidimensional Analysis Based on Global Panel Data

In this paper, we examined the impact of financial development on renewable energy consumption from a global perspective based on a dynamic panel model and panel data of 103 economies. We conducted the research from the different levels of financial development using an index system including nine variables, and also explored national heterogeneity by dividing samples into developed economies and developing economies. The empirical results indicated that the financial development had a positive impact on renewable energy consumption from the macro perspective, and this effect was mainly driven by the development of a financial institution (mainly including bank). Further analysis on the depth, access, and efficiency of a financial institution and financial market (mainly including stock market and bond market) revealed that all three aspects of a financial institution had a positive influence on renewable energy consumption, while this effect only existed in the aspect of efficiency for a financial market. The investigation of national heterogeneity showed that the financial development performed well in promoting renewable energy consumption in developed economies, while this positive effect only existed for financial institutions in developing economies. We suggest to policymakers to attach importance to the positive effect of financial development when formulating renewable-energy-related policies, and provide a system guarantee for renewable energy enterprises concerning financial sectors in developing economies.
UAV Path Planning Optimization Strategy: Considerations of Urban Morphology, Microclimate, and Energy Efficiency Using Q-Learning Algorithm

The use of unmanned aerial vehicles (UAVS) has been suggested as a potential communications alternative due to their fast implantation, which makes this resource an ideal solution to provide support in scenarios such as natural disasters or intentional attacks that may cause partial or complete disruption of telecommunications services. However, one limitation of this solution is energy autonomy, which affects mission life. With this in mind, our group has developed a new method based on reinforcement learning that aims to reduce the power consumption of UAV missions in disaster scenarios to circumvent the negative effects of wind variations, thus optimizing the timing of the aerial mesh in locations affected by the disruption of fiber-optic-based telecommunications. The method considers the K-means to stagger the position of the resource stations—from which the UAVS launched—within the topology of Stockholm, Sweden. For the UAVS’ locomotion, the Q-learning approach was used to investigate possible actions that the UAVS could take due to urban obstacles randomly distributed in the scenario and due to wind speed. The latter is related to the way the UAVS are arranged during the mission. The numerical results of the simulations have shown that the solution based on reinforcement learning was able to reduce the power consumption by 15.93% compared to the naive solution, which can lead to an increase in the life of UAV missions.
The stability of plane Poiseuille flow between flexible walls

This paper examines the linear stability of antisymmetric disturbances in incompressible plane Poiseuille flow between identical flexible walls which undergo transverse displacements. Using a variational approach, an approximate solution of the problem is formulated in a form suitable for computational evaluation of the (complex) wave speeds of the system. A feature of this formulation is that the varying boundary conditions (and the Orr-Sommerfeld equation) are satisfied only in the mean; this reduces the labour involved in determining the approximate solution for a variety of wall conditions without increasing the difficulty of obtaining solutions to a given accuracy. In this paper the symmetric stream function distribution across the channel is represented by a series of cosines whose coefficients are determined by the variational solution. Comparisons with previous work, both for the flexible-wall and rigid-wall problems, show that the method gives results as accurate as those obtained previously by other methods while new results, for flexible walls, indicate the presence of a higher wave-number stability boundary which joins the distorted Tollmien-Schlichting stability boundary at lower wave-numbers. In some cases this upper unstable region, which is characterized by large amplification rates, may determine the critical Reynolds number of the system.
Opposing effects of KDM6A and JDP2 on glucocorticoid sensitivity in T-ALL

Key Points • KDM6A inactivation sensitizes T-ALL cells to glucocorticoids, enforces JDP2 expression, reverses this phenotype, and causes resistance. • Alterations in KDM6A and JDP2 modulate glucocorticoid-induced NR3C1 mRNA and glucocorticoid receptor protein expression in T-ALL cells.