Miracle-dz/UniFAR-FTUs huggingface dataset:
Collective motions in proteins: A covariance analysis of atomic fluctuations in molecular dynamics and normal mode simulations

A method is described for identifying collective motions in proteins from molecular dynamics trajectories or normal mode simulations. The method makes use of the covariances of atomic positional fluctuations. It is illustrated by an analysis of the bovine pancreatic trypsin inhibitor. Comparison of the covariance and cross‐correlation matrices shows that the relative motions have many similar features in the different simulations. Many regions of the protein, especially regions of secondary structure, move in a correlated manner. Anharmonic effects, which are included in the molecular dynamics simulations but not in the normal analysis, are of some importance in determining the larger scale collective motions, but not the more local fluctuations. Comparisons of molecular dynamics simulations in the present and absence of solvent indicate that the environment is of significance for the long‐range motions.
Enumeration of Branched Coverings of Nonorientable Surfaces With Cyclic Branch Points

In this paper, n-fold branched coverings of a closed nonorientable surface ${\mathcal S}$ of genus p with $r\geq 1$ cyclic branch points (that is, such that all ramification points over them are of multiplicity n) are considered. The number Np,r(n) of such coverings up to equivalence is evaluated explicitly in a closed form (without using any complicated functions such as irreducible characters of the symmetric groups). The obtained formulas depend on the parity of r and n. The method is based on some previous enumerative results and techniques for nonorientable surfaces. In particular, we generalize the approach developed for the counting of unbranched coverings of nonorientable surfaces and make use of the analytical method of roots-of-unity sums.
A step by step Methodological approach to appraise the quality of written feedback using Comment Analysis

Several studies have been conducted to analyze the quality of written feedback given by teachers on students’ written assignments. However, it has been observed that there is no clear existing method or tool to facilitate the analysis of teachers’ written feedback. This paper aims to document a step by step methodological approach to analyze teachers’ comments and appraise the quality of feedback on students’ written assignments. A self-initiated tool was developed from the comment analysis process which revealed the use of various formats and modes employed to provide written feedback to the students. In addition, this tool helped to determine the focus and tone of the feedback. Using a step by step approach, the tool also helped to identify clarity in the given feedback. This paper is an addition to the existing literature in the qualitative research method for in-depth analysis of teachers’ comments. This effort will not only appraise the quality of Method Article Ghazal et al.; BJESBS, 10(4): 1-10, 2015; Article no.BJESBS. 17713 2 given feedback but also help in further development of a comprehensive qualitative tool to assess its quality.
Lymphocyte transformation. Absence of increased responses in alleged halothane jaundice.

In vitro tests for cell-mediated immunity were conducted in a group of patients and physicians whose histories suggested the possibility of hypersensitivity to halothane. The results of tests for lymphocyte transformation in these subjects were not significantly different from the results in a group of normal controls. These findings, therefore, have failed to confirm previously reported work, in which it was claimed that positive lymphocyte transformation was demonstrated in ten of 15 patients with alleged halothane hepatitis.
Block Jam: A Tangible Interface for Interactive Music

In this paper, we introduce Block Jam, a Tangible User Interface that controls a dynamic polyrhythmic sequencer using 26 physical artifacts. These physical artifacts, that we call blocks, are a new type of input device for manipulating an interactive music system. The blocks’ functional and topological statuses are tightly coupled to an ad hoc sequencer, interpreting the user’s arrangement of the blocks as meaningful musical phrases and structures. We demonstrate that we have created both a tangible and visual language that enables both the novice and musically trained users by taking advantage of both their explorative and intuitive abilities. The tangible nature of the blocks and the intuitive interface promotes face-to-face collaboration and social interaction within a single system. Linking two Block Jam systems together to create a network further extends the principle of collaboration. We discuss our project vision, design rational, related works, and the implementation of Block Jam prototypes.
Fluid shear stress regulates vascular remodeling via VEGFR-3 activation, although independently of its ligand, VEGF-C, in the uterus during pregnancy

Early pregnancy is characterized by an increase in the blood volume of the uterus for embryonic development, thereby exerting fluid shear stress (FSS) on the vascular walls. The uterus experiences vascular remodeling to accommodate the increased blood flow. The blood flow-induced FSS elevates the expression of vascular endothelial growth factors (VEGFs) and their receptors, and regulates vascular remodeling through the activation of VEGF receptor-3 (VEGFR-3). However, the mechanisms responsible for FSS-induced VEGFR-3 expression in the uterus during pregnancy are unclear. In this study, we demonstrate that vascular remodeling in the uterus during pregnancy is regulated by FSS-induced VEGFR-3 expression. We examined the association between VEGFR-3 and FSS through in vivo and in vitro experiments. In vivo experiments revealed VEGFR-3 expression in the CD31-positive region of the uterus of pregnant mice; VEGF-C (ligand for VEGFR-3) was undetected in the uterus. These results confirmed that VEGFR-3 expression in the endometrium is independent of its ligand. In vitro studies experiments revealed that FSS induced morphological changes and increased VEGFR-3 expression in human uterine microvascular endothelial cells. Thus, VEGFR-3 activation by FSS is associated with vascular remodeling to allow increased blood flow in the uterus during pregnancy.
L'étendue internationale des nouvelles firmes de hautes technologies: le rôle du capital humain et de l'intention stratégique des fondateurs

De recentes recherches ont mis l’accent sur l’importance pour les nouvelles entreprises internationales de l’existence de ressources et de competences specifiques. La presente recherche, qui s’inscrit dans ce courant, montre en particulier l’importance du capital humain acquis par les entrepreneurs sur base de leur experience internationale passee. Mais nous montrons en meme temps que ces organisations sont soutenues par une intention deliberee d’internationalisation des l’origine. Notre recherche empirique est basee sur l’analyse d’un echantillon de 466 nouvelles entreprises de hautes technologies anglaises et allemandes. Nous montrons que ce capital humain est un actif qui facilite la penetration rapide des marches etrangers, et plus encore quand l’entreprise nouvelle est accompagnee d’une intention strategique deliberee d’internationalisation. Des conclusions similaires peuvent etre etendues au niveau des ressources que l’entrepreneur consacre a la start-up : plus ces ressources sont importantes, plus le processus d’internationalisation tend a se faire a grande echelle ; et la aussi, l’influence de ces ressources est augmente par l’intention strategique d’internationalisation. Dans le cadre des etudes empiriques sur les born-globals (entreprises qui demarrent sur un marche globalise), cette recherche fournit une des premieres etudes empiriques reliant l’influence des conditions initiales de creation aux probabilites de croissance internationale rapide.
Remembered Utility of Unpleasant and Pleasant Learning Experiences: Is All Well that Ends Well?

Summary Retrospective evaluation of the pain or pleasure associated with past episodes (i.e. remembered utility) is mainly determined by how the episodes felt when they were at their peak, and when they ended (Kahneman, Fredrickson, Schreiber, & Redelmeier, 1993). Two experiments were conducted to investigate whether this memory bias known as the peak-end rule also affects the remembered utility of learning episodes and shapes study behaviour. Both the first experiment, which focused on unpleasant learning experiences imposing a very high cognitive load, and the second experiment, which focused on pleasant learning experiences imposing a low cognitive load, presented primary school children with a short study list and an extended study list with English–Dutch word pairs. Results showed that study experiences that ended on an experienced peak affect were evaluated as easier to learn and easier to cope with. These measures of remembered utility shaped children's immediate and delayed study behaviour. In addition, the pattern of affect induced by the word pairs that were added to the extended study list in both experiments suggests that the experience with new learning tasks is relative to the affect induced by the original learning task. The findings are congruent with the peak-end rule and support the position that the design of learning environments could be improved by taking remembered utility into account. Copyright © 2012 John Wiley & Sons, Ltd.
The Montreal Cognitive Assessment (MoCA) is Superior to the Mini Mental State Examination (MMSE) in Detection of Korsakoff’s Syndrome

The Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) are brief screening instruments for cognitive disorders. Although these instruments have frequently been used in the detection of dementia, there is currently little knowledge on the validity to detect Korsakoff’s syndrome (KS) with both screening instruments. KS is a chronic neuropsychiatric disorder associated with profound declarative amnesia after thiamine deficiency. A representative sample of 30 patients with KS and 30 age-, education-, gender- and premorbid-IQ-matched controls was administered the MoCA and MMSE. The area under the receiver operating characteristic curve (AUC) was calculated in addition to the sensitivity, specificity, positive predictive value, and negative predictive value for various cut-off points on the MoCA and MMSE. Compared with the MMSE, the MoCA demonstrated consistently superior psychometric properties and discriminant validity—AUC: MoCA (1.00 SE .003) and MMSE (0.92 SE .033). When applying a cut-off value as suggested in the manuals of both instruments, the MMSE (< 24) misdiagnosed 46.7% of the patients, while the MoCA (< 26) diagnosed all patients correctly. As a screening instrument with the most optimal cut-offs, the MoCA (optimal cutoff point 22/23, 98.3% correctly diagnosed) was superior to the MMSE (optimal cutoff point 26/27, 83.3% correctly diagnosed). We conclude that both tests have adequate psychometric properties as a screening instrument for the detection of KS, but the MoCA is superior to the MMSE for this specific patient population.
Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects

The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40–50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway flux (JawNO), airway diffusing capacity (DawNO) and airway wall content (CawNO) will also demonstrate this dependence. Data from healthy subjects were gathered by the current authors from their earlier publications in which healthy individuals were included as control subjects. Healthy subjects (n = 433) ranged in age from 7 to 78 years. Age-stratified reference values of the NO parameters were significantly different. Gender differences were only observed in the 20–49 age group. The results from the multiple regression models in subjects older than 20 years revealed that age, height and gender interaction together explained 6% of variation in FENO at 50 ml s−1 (FENO50), 4% in JawNO, 16% in CawNO, 8% in DawNO and 12% in CANO. In conclusion, in this study we have generated reference values for NO parameters from an extended NO analysis of healthy subjects. This is important in order to be able to use these parameters in clinical practice.
Intrapersonal factors, social context and health-related behavior in adolescence

Previous studies indicate that self-esteem is lower among adolescents of low socioeconomic status and is associated with a number of intrapersonal, interpersonal and sociocultural factors. Evidence on the mechanisms by which these factors contribute to the connection between socioeconomic status and developing self-esteem is incomplete, however. The purpose of this cross-sectional study is to assess whether personality, mental health and social support contribute to the relationship between socioeconomic status and self-esteem. A sample of 3,694 elementaryschool students from Slovakia (mean age 14.3 years, 49% boys) fi lled out the Rosenberg Self-esteem scale, the Family affl uence scale, the Ten-Item Personality Inventory, the 12-item General Health Questionnaire and the Perceived Social Support Scale. Hierarchical linear regression showed family affl uence, personality dimensions of extroversion, emotional stability and openness to experience, as well as mental health subscales and social support from family and signifi cant others to be associated with self-esteem. Results indicate that personality dimensions and mental health subscales contribute to the association between family affl uence and self-esteem. The contribution of personality and mental problems in the relation between socioeconomic status and self-esteem may have important implications for the design of promotional programs aimed at enhancing self-esteem.
Optimal design of repetitive controller for harmonic elimination in PWM voltage source inverters

This paper presents an analysis of the application and optimal design of the repetitive controller for eliminating harmonic distortion in pulse-width modulation voltage source inverter systems. A method of analyzing the repetitive control system from the frequency response viewpoint is introduced. Based on this method, a systematic way of optimizing the design of the system is proposed. Specifically, the closed-loop repetitive controller is modified by including a zero-magnitude-and-phase compensator and a lead-lag compensator to improve the stability and tracking accuracy of the inverter system. It is shown both analytically and by simulations that the harmonics in the inverter's output voltage can be effectively eliminated with the improved repetitive controller.
SURFACE DESIGN IN VIRTUAL REALITY AS INDUSTRIAL APPLICATION

The authors present SpaceDesign, a computer-aided styling application addressed to the early stages of the design process. Virtual Reality devices are used for expressing first design ideas in an unconstrained and natural way, like e.g. sketching shapes. The creative phase is supported by means of intuitive generation of surface functions in a semi-immersive environment. The industrial requirements are fulfilled by means of importing standard CAD file formats and keeping the mathematical representation of the models. Innovative features are provided: real time preview during the surface sketching, the navigation tool and 3D-constrained-interaction techniques with visual feedback. This combination of features makes our approach unique in comparison to similar systems.
Optimal Cell Assignment Algorithms for Pico-Cell Networks

The proliferation of smartphones has unleashed a tremendous growth in wireless traffic, which is projected to continue for the foreseeable future, and put yet greater strain on the capacity of cellular networks. Deployment of pico base stations, reducing cell sizes and allowing more efficient reuse of limited radio spectrum, provides a powerful approach to cope with traffic hot spots and bring capacity relief. This network densification raises a critical need for more intelligent cell selection algorithms, which not only take signal strength values into account, but also load conditions in order to harness the full potential of the pico cells. We describe how the problem of optimally balancing traffic loads among pico cells may be formulated as a linear program (LP), and show how the dual version of the LP provides insight in the structure of the optimal user association. Since the LP formulation involves several system parameters that tend to be time-varying and hard to estimate in practice, the optimal user association can not be calculated in a direct way. Hence, we develop various online cell selection algorithms that solve the LP and determine the optimal user association in a measurement-based manner, without requiring explicit knowledge of the system parameters. Extensive simulation experiments confirm that the algorithms are quite effective in optimally balancing the traffic loads, and further demonstrate that they substantially outperform conventional approaches in terms of user-perceived throughput performance.
Statistics in respiratory medicine. 2. Repeatability and method comparison.

Repeatability and reference ranges for change A measurement that is totally unrepeatable clearly has no validity. Repeatability, however, or reproducibility, is an ambiguous concept without precise definition. To a clinical chemist it may mean reproducibility of results from an autoanalyser for a single blood sample. A technician may spend hours perfecting a non-automatic technique. But if two blood samples taken from the same subject within hours give very different results laboratory repeatability may be relatively unimportant. 'T'he repeatability of most respiratory measurements is necessarily of the "time to time" type with the interval between measurements measured at least in minutes but possibly in hours or days. Differences in the results obtained depend on the time gap, the variation increasing-that is, repeatability decreasing-with the length of the gap. Neild 7t al ' measured forced expiratory volume in one second (FEV,), peak expiratory flow (PEF), respiratory resistance, and specific airway conductance in 25 non-asthmatic subjects three times on each of three consecutive days, and reported the "within subject within day" variance of each, and also the estimate of additional variance due to variation within subjects but between days. Variances were used in the paper by Neild et al' because components of variance may be added. The usual measure of repeatability when only within day or only between day variation is studied is the within subject standard deviation. If more than two repeat measurements are carried out for some or all subjects then repeatability is most easily calculated from the results of a one way anaiysis of variance, with "subjects" as the "group" variable. The within subject standard deviation is the square root of the pooled within subject sum of squares divided by its degrees of freedom (that is, for those used to analysis of variance terminology, of the residual "mean square"). Frequently repeatability studies are carried out with just two repeat measurements per subject; indeed, for most purposes this is the most efficient design. 'Fhen it is natural to take the differences between the first and second measurements for cach subject. For example, C(hinn et al,2 from a study designed to assess rcpeatability of histamine challenge tests, reported the mean difference between the postsaline FEV values mcasured in 107 subiects <^ two occasions as 0-01 litres and the standard deviation of the differences as 0-42 1. To convert a standard deviation of differences, which has double the variance of a single FEV,, to a within subject standard deviation of a single FEV, we divide 0-42 by , 2 to get 0-30. Strictly speaking, the fact that the mean difference is not exactly zero but 0-01 should be taken into account. The within subject standard deviation is actually
The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins.

Abstract The ability of hepatic plasma membranes to bind desialylated glycoproteins as a prelude to transport and catabolism has been reported earlier. The present study describes the purification, by affinity chromatography, of an hepatic protein which retains the characteristic binding properties associated with the membranes. The isolated material, which is watersoluble and free from lipids, has been identified as a glycoprotein in which 10 % of the dry weight consists of sialic acid, galactose, mannose, and glucosamine in a molar ratio of 1:1:2:2. The integrity of the terminal sialic acid residues and the presence of calcium were shown to be absolute requirements for binding. Physical chemical studies indicated a high degree of aggregation in the final, water-soluble preparation.
Enhancing Affective Communication in Embodied Conversational Agents

Embodied Conversational Agents (ECAs) are computergenerated characters whose purpose is to exhibit the same properties as humans in face-to-face conversation. The general goal of researchers in the field of ECAs is to create agents that can be more natural, believable and easy to use. In this paper, we are interested in increasing believability of ECAs. Specifically, we are interested in making the intentionality of the agent believable regarding actions and reactions that create the impression of an independent entity with goals and, specially, feelings.
Pre-positioning of Emergency Supplies for Disaster Response

We describe a two-stage stochastic optimization model for determining locations of emergency supplies and allocating quantities of those supplies. The model includes uncertainty in what the demands for various types of supplies might be, and the locations where those demands might arise. It also includes uncertainties in the capacity of the transportation network to allow movements of supplies from pre-positioning locations to demands, and the possibility that some of the pre-positioned supplies might be destroyed by the event. The formulation can include multiple supply types, including equipment (e.g., portable electric generators), non- consumable supplies (e.g., tents, blankets, etc.), and consumable supplies (e.g., food, water, medicine, etc.). A case study for the southeastern United States illustrates the use of the model.
Motion planning for the fast opening of the protection cover based on high order polynomial interpolation

A high order polynomial interpolation method is proposed for the motion planning of the fast opening of the protection cover, which is based on its characteristics to ensure the steady ability. Fifth-order polynomial is chosen to complete the motion planning, and subsection search method is employed to set its acceleration. Optimal planning path is achieved after several subsection searching, and MATLAB simulation confirms the validity and efficiency of the proposed method.