Miracle-dz/UniFAR-FTUs huggingface dataset:
World Journal of Surgical Oncology Open Access Research Prognostic Value of Hmgb1 Overexpression in Resectable Gastric Adenocarcinomas

article distributed under the terms of the Creative Commons At-tribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction: HMGB1(High mobility group box 1), originally described as a nuclear protein, is now regarded as a multifunctional protein with a paradoxical dual effect in tumors. In the present study, HMGB1 overexpression and its correlation with the clinicopathologic characteristics and recurrence-free survival were evaluated in gastric adenocarcinomas. Methods: 76 gastric adenocarcinomas surgically removed entered the study. The immunohistochemical staining was used to assess HMGB1 expression through tissue microarray procedure. The clinicopathologic characteristics of all patients were recorded, and the regular follow-up was made for all patients. Results: Almost all the gastric adenocarcinomas showed HMGB1 positive staining mainly in the nucleus, and the overexpression of HMGB1 was found in cancerous tissues with higher strong reactivity rate, compared with non-cancerous tissues (total expression score ≥ 9, 42.0% vs. 9.0%, P < 0.001). Survival analysis revealed that tumor stage negatively correlated with cancer-free survival (P = 0.022). Furthermore, HMGB1 overexpression positively associated with cancer-free survival of resectable gastric adenocarcinomas (P = 0.023). Conclusions: The overexpression of HMGB1 protein indicates that HMGB1 may play a role in the tumorigenesis of gastric adenocarcinomas. And the overexpression of HMGB1 may be a marker of good prognosis of gastric adenocarcinoma given curative resection combined with adjuvant chemotherapy. Introduction Gastric cancer (GC) is the second most common cause of cancer-related death in the world. Many Asian countries, including China, have very high rates of GC. For patients in advanced stages, the five-year survival rate is only about 20 percent. There are many factors that limit the prognosis of the disease. High mobility group box l (HMGB1), a nuclear DNA-binding protein, originally described as a nuclear protein that binds to and modifies DNA, stabilizes the structure and function of chromatin and regulates gene transcription. It has been realized that HMGB1 can act either as a DNA binding protein or extracellularly as a cytokine-like danger signal, which is either actively secreted or passively released by necrotic cells[1]. Now HMGB1 is regarded as a central mediator of inflammation by acting as a cytokine, which has been
Impact of High-κ Gate Stacks on Transport and Variability in Nano-CMOS Devices

Scaling of Si MOSFETs beyond the 90 nm technology node requires performance boosters in order to satisfy the International Technology Roadmap for Semiconductors (ITRS) requirements for drive current in high-performance transistors. Amongst the preferred near term solutions are transport enhanced FETs utilising strained Si (SSi) channels. Additionally, high-kappa dielectrics are expected to replace SiO2 around or after the 45 nm node to reduce the associated gate leakage current problem, facilitating further scaling. However, in spite of significant recent technological achievements, in particular, in reducing charge trapping and crystallization of the dielectric, mobility degradation in the devices with the high-kappa gate stacks caused, in part, by the strong soft optical phonon scattering leaves room for further performance improvement. In this work we study the impact of soft optical phonon scattering on the mobility and device performance for conventional and strained Si n-MOSFETs with high-kappa dielectrics using a self-consistent Poisson Ensemble Monte Carlo device simulator, with effective gate lengths of 67 and 35 nm
Long Interspersed Element–1 (LINE-1): Passenger or Driver in Human Neoplasms?

LINE-1 (L1) retrotransposons make up a significant portion of human genomes, with an estimated 500,000 copies per genome. Like other retrotransposons, L1 retrotransposons propagate through RNA sequences that are reverse transcribed into DNA sequences, which are integrated into new genomic loci. L1 somatic insertions have the potential to disrupt the transcriptome by inserting into or nearby genes. By mutating genes and playing a role in epigenetic dysregulation, L1 transposons may contribute to tumorigenesis. Studies of the “mobilome” have lagged behind other tumor characterizations at the sequence, transcript, and epigenetic levels. Here, we consider evidence that L1 retrotransposons may sometimes drive human tumorigenesis.
What Makes a Good Plan? An Efficient Planning Approach to Control Diffusion Processes in Networks

In this paper, we analyze the quality of a large class of simple dynamic resource allocation (DRA) strategies which we name priority planning. Their aim is to control an undesired diffusion process by distributing resources to the contagious nodes of the network according to a predefined priority-order. In our analysis, we reduce the DRA problem to the linear arrangement of the nodes of the network. Under this perspective, we shed light on the role of a fundamental characteristic of this arrangement, the maximum cutwidth, for assessing the quality of any priority planning strategy. Our theoretical analysis validates the role of the maximum cutwidth by deriving bounds for the extinction time of the diffusion process. Finally, using the results of our analysis, we propose a novel and efficient DRA strategy, called Maximum Cutwidth Minimization, that outperforms other competing strategies in our simulations.
An Investigation of FrFT Modulation and FFT-OFDM for Multiple Input Multiple Output Application

This work presents a study of the Fractional Fourier Transform (FrFT) modulation scheme for Multiple Input Multiple Output (MIMO) multicarrier systems. Two forms of FrFT modulation techniques were observed; one involved the FrFT-OFDM implementation style with cyclic prefix, while the other precludes the FrFT following some established logical signal processing justifications. Then, both were compared with the traditional FFT-OFDM. Each in its own case was used as the multiplexing kernel in the baseband for driving MIMO system. With up to 2x2 MIMO transmitter-receiver diversities, we found that the FrFT modulation precluding the cyclic prefix slightly outperforms the traditional FrFT-OFDM modulation technique. However, FFT-OFDM which is highly robust over frequency selective channel outperformed the FrFT modulations.
Companied Edge Flow Histogram and Color Histogram to Represent Tracking Objects

Tracking moving objects from moving platform in videos sequence is a challenging task . object movement and platform movement are sources of variations in scene. Mean Shift Algorithm (MSA) is the common tracking algorithm due simple and efficient procedure. Correct Background Weight Histogram(CBWH)decrease background effect in target representation module . The main drawbacks in MSA is the ineffective model representation to handle illumination variation and occultation problems . MSA failed to track objects in video containing wide ranges of variations and background motion. In this paper motion information is exploited from edge flow by gradient differential. Histogram for edge flow combined with color histogram called Motion Flow Histograms (MFH). MFH used to represent tracking target between two successive frames. New module target representation reduces the false tracker rate without evident increasing time compare to the classical tracking MSA and CBWH. General Terms Moving platform, tracking algorithm
OryzaGenome: Genome Diversity Database of Wild Oryza Species

The species in the genus Oryza, encompassing nine genome types and 23 species, are a rich genetic resource and may have applications in deeper genomic analyses aiming to understand the evolution of plant genomes. With the advancement of next-generation sequencing (NGS) technology, a flood of Oryza species reference genomes and genomic variation information has become available in recent years. This genomic information, combined with the comprehensive phenotypic information that we are accumulating in our Oryzabase, can serve as an excellent genotype–phenotype association resource for analyzing rice functional and structural evolution, and the associated diversity of the Oryza genus. Here we integrate our previous and future phenotypic/habitat information and newly determined genotype information into a united repository, named OryzaGenome, providing the variant information with hyperlinks to Oryzabase. The current version of OryzaGenome includes genotype information of 446 O. rufipogon accessions derived by imputation and of 17 accessions derived by imputation-free deep sequencing. Two variant viewers are implemented: SNP Viewer as a conventional genome browser interface and Variant Table as a text-based browser for precise inspection of each variant one by one. Portable VCF (variant call format) file or tab-delimited file download is also available. Following these SNP (single nucleotide polymorphism) data, reference pseudomolecules/scaffolds/contigs and genome-wide variation information for almost all of the closely and distantly related wild Oryza species from the NIG Wild Rice Collection will be available in future releases. All of the resources can be accessed through http://viewer.shigen. info/oryzagenome/.
Heart Rhythm Monitoring Strategies for Cryptogenic Stroke: 2015 Diagnostics and Monitoring Stroke Focus Group Report

Stroke is a major public health issue worldwide. The prevalence of stroke in 2010 was 33 million, with 16.9 million people having a first stroke. [1][1] Stroke was the second‐leading cause of death behind heart disease globally, accounting for over 10% of total deaths worldwide. [1][1] Stroke is
Heme Oxygenase-1 Induction and Organic Nitrate Therapy: Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress

Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents, and this phenomenon is largely based on induction of oxidative stress with subsequent endothelial dysfunction. We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects. Indeed, we found that hemin cotreatment prevented the development of nitrate tolerance and vascular oxidative stress in response to chronic nitroglycerin therapy. Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1+/– mice. Recently, we identified activation of Nrf2 and HuR as a principle mechanism of HO-1 induction by PETN. With the present paper, we present and discuss our recent and previous findings on the role of HO-1 for the prevention of nitroglycerin-induced nitrate tolerance and for the beneficial effects of PETN therapy.
Elevator Group Control Scheduling Approach Based on Multi-Agent Coordination*

Elevator group control scheduling problem is considered using the approach of multi-agent coordination. Unlike traditional elevator group control scheduling approaches that were implemented by a central agent, this scheduling proposed in this paper was implemented by many elevator agents, and every agent is able to calculate, reason and decide. Based on this, the structure of single elevator agent and the structure of system are designed, and coordination mechanism is then defined. Finally, in computer, the algorithm is simulated and compared with other scheduling algorithms. The results show the approach proposed in the paper can reduce effectively the average waiting time of passengers and rate of waiting long time of passengers, and it indicates an excellent applicability at most of traffic flow pattern
A Cross-Linguistic Study on the Production of Multimodal Referring Expressions in Dialogue

This paper presents a cross-linguistic data elicitation study on fully realised referring expressions (REs) in a dialogue context. A webbased experiment was set up in which participants were asked to choose REs to be uttered by one of two agents for identifying five targets in a scripted dialogue. Participants were told that the agent would point at the referents while uttering their chosen linguistic descriptions. The study was conducted in English, Japanese, Portuguese and Dutch and yielded a total of 1190 referring expressions. Our hypotheses concern sets of objects that need to be considered for identification depending on the effect of the pointing gesture. Results show interesting and significant differences between the language groups.
Open Strings in Exactly Solvable Model of Curved Spacetime and PP-Wave Limit

In this paper we study the superstring version of the exactly solvable string model constructed by Russo and Tseytlin. This model represents superstring theory in a curved spacetime and can be seen as a generalization of the Melvin background. We investigate D-branes in this model as probes of the background geometry by constructing the boundary states. We find that spacetime singularities in the model become smooth at high energy from the viewpoint of open string. We show that there always exist bulk (movable) D-branes by the effect of electric flux. The model also includes Nappi-Witten model as the Penrose limit and supersymmetry is enhanced in the limit. We examine this phenomenon in the open string spectrum. We also find the similar enhancement of supersymmetry can occur in several coset models.
Unique prospects for graphene-based terahertz modulators

The modulation depth of two-dimensional electron-gas (2DEG) based terahertz (THz) modulators using AlGaAs/GaAs hetero-structures with metal gates is inherently limited to <30%. The metal gate not only attenuates the THz signal but also severely degrades modulation depth. Metal losses can be significantly reduced employing an alternative material with tunable conductivity. Graphene presents a unique solution to this problem due to its symmetric band structure and extraordinarily high hole mobility. In this work, we show that it is possible to achieve a modulation depth of >90% while simultaneously minimizing signal attenuation to <5% by tuning the Fermi level at its Dirac point. VC 2011 American Institute of Physics. [doi:10.1063/1.3636435]
DaSIAn: A Tool for Estimating the Impact of Database Schema Modifications on Web Applications

In the light of the extraordinary and continuous growth of the Web, there is a significant development shift from traditional software applications to web applications. The spread of this type of applications raises a demand for new approaches towards their testing and maintenance. Contrary to most previous proposals our interest focuses on the interaction between a web application and its underlying database. This paper describes an approach for the estimation of the impact that database schema modifications imply to the operability of a web application. In addition, a software tool called DaSIAn that is based upon this proposal is presented and its experimental results are being discussed.
Exploring the Playfulness of Tools for Co-Designing Smart Connected Devices: A Case Study with Blind and Visually Impaired Students

In this paper we compare two tools for co-designing smart connected devices on their playfulness. First littleBits, a commercially available tool and Loaded Dice, a self developed tool, are introduced. Second frameworks for comparing the playfulness of such tools are briefly reviewed. We then report on co-design sessions we conducted with blind and visually impaired students and compare those sessions on the playfulness of the two tools. It is shown how tools that engage in playful exploration sustain successful co-design sessions, while tools with a lower level of playfulness constrain such co-design sessions to an extent where more functional and less imaginative design concepts are produced.
A Novel Immunodiagnostic Assay to Detect Serum Antibody Response against Selected Soluble Egg Antigen Fractions from Schistosoma japonicum

Background Schistosomiasis japonica remains a real threat to public health in China. The currently used immunodiagnostic assays are sensitive and have a certain degree of specificity, however, they all use complex crude antigens, are based on detection of schistosome-specific antibodies, and have been shown to cross-react with other parasitic diseases. Therefore, these assays cannot be used to evaluate chemotherapy efficacy. The development of highly sensitive and highly specific immunodiagnostic techniques that can monitor the decline of antibodies specific for S. japonica will be extremely valuable as part of the ongoing strategy to control schistosomiasis in endemic areas. Here we report on the identification of unique fraction antigens of soluble egg antigen (SEA) to which the antibodies disappear 7 weeks after effective treatment. Furthermore, we use these SEA fractions to develop a modified assay with both high sensitivity and specificity. Methodology/Principal Findings SEA of S. japonicum was fractionated by electrophoresis using 7.5% SDS-PAGE under non-reducing conditions. The SEA fraction antigens to which antibodies were decreased soon after treatment were collected and used as the detection antigens to establish the FA-ELISA. Sera from patients with acute and chronic schistosomiasis infection, healthy people, and those with other parasitic diseases, were used to evaluate their sensitivity and specificity. Furthermore, sera from patients with chronic schistosomiasis infection were evaluated before and after treatment at different time points to evaluate their chemotherapeutic efficacy. Conclusion/Significance We demonstrated that this novel FA-ELISA provided high sensitivity and specificity, with very low cross-reactivity, and can serve as an effective tool to determine the efficacy of chemotherapy against S. japonicum.
Transport System Architecture Services for High-Performance Communications Systems

Transport system services that integrate operating system resources such as CPUs, virtual memory, and I/O devices with network protocols to support distributed multimedia applications running on local and wide area networks are described and classified. A taxonomy is presented, and four commercial and experimental transport systems are compared and evaluated in terms of their protocol processing support. The systems discussed are System V UNIX STREAMS, the BSD UNIX networking subsystem, the x-kernel, and the Choices Conduit system. >
Child Abuse & Neglect easuring a year of child pornography trafficking by U . S . omputers on a peer-to-peer network

We used data gathered via investigative “RoundUp” software to measure a year of online child pornography (CP) trafficking activity by U.S. computers on the Gnutella peer-to-peer network. The data include millions of observations of Internet Protocol addresses sharing known CP files, identified as such in previous law enforcement investigations. We found that 244,920 U.S. computers shared 120,418 unique known CP files on Gnutella during the study year. More than 80% of these computers shared fewer than 10 such files during the study year or shared files for fewer than 10 days. However, less than 1% of computers (n = 915) made high annual contributions to the number of known CP files available on the network (100 or more files). If law enforcement arrested the operators of these high-contribution computers and took their files offline, the number of distinct known CP files available in the P2P network could be reduced by as much as 30%. Our findings indicate widespread low level CP trafficking by U.S. computers in one peer-to-peer network, while a small percentage of computers made high contributions to the problem. However, our measures were not comprehensive and should be considered lower bounds estimates. Nonetheless, our findings show that data can be systematically gathered and analyzed to develop an empirical grasp of the scope and characteristics of CP trafficking on peer-to-peer networks. Such measurements can be used to combat the problem. Further, investigative software tools can be used strategically to help law enforcement prioritize investigations. © 2013 Elsevier Ltd. All rights reserved.
Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation

Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD mainly takes place in the substantia nigra pars compacta (SN) region, other brain areas, including the prefrontal cortex, develop Lewy bodies, the neuropathological hallmark of PD. We generated and analyzed expression data from the prefrontal cortex Brodmann Area 9 (BA9) of 27 PD and 26 control samples using the 44K One-Color Agilent 60-mer Whole Human Genome Microarray. All samples were male, without significant Alzheimer disease pathology and with extensive pathological annotation available. 507 of the 39,122 analyzed expression probes were different between PD and control samples at false discovery rate (FDR) of 5%. One of the genes with significantly increased expression in PD was the forkhead box O1 (FOXO1) transcription factor. Notably, genes carrying the FoxO1 binding site were significantly enriched in the FDR–significant group of genes (177 genes covered by 189 probes), suggesting a role for FoxO1 upstream of the observed expression changes. Single-nucleotide polymorphisms (SNPs) selected from a recent meta-analysis of PD genome-wide association studies (GWAS) were successfully genotyped in 50 out of the 53 microarray brains, allowing a targeted expression–SNP (eSNP) analysis for 52 SNPs associated with PD affection at genome-wide significance and the 189 probes from FoxO1 regulated genes. A significant association was observed between a SNP in the cyclin G associated kinase (GAK) gene and a probe in the spermine oxidase (SMOX) gene. Further examination of the FOXO1 region in a meta-analysis of six available GWAS showed two SNPs significantly associated with age at onset of PD. These results implicate FOXO1 as a PD–relevant gene and warrant further functional analyses of its transcriptional regulatory mechanisms.
Foreign Investment and International Plant Configuration: Whither the Product Cycle?

We analyze the determinants of the decision to invest abroad in particular configurations of overseas plants for 120 Japanese firms active in 36 well-defined electronic product markets. We find support for a structured internationalization decision model in which the decision to produce abroad and the choice for a specific international plant configuration are treated as nested strategic options. Drivers at the industry and firm level push firms to consider overseas investment, and locational characteristics pull firms towards particular plant configurations. The product cycle still appears as an important force pushing firms to set up Asia-focused or global plant configurations. In contrast, plant configurations focused on the US and the EU are a result of restrictive trade policies or offensive market access considerations vital to technology intensive firms facing competitive threats in foreign markets.