Miracle-dz/UniFAR-FTUs huggingface dataset:
Quadriceps weakness in knee osteoarthritis: the effect on pain and disability

OBJECTIVES (1) To determine the importance of quadriceps strength, structural change, and psychological status in terms of knee pain in the community. (2) To determine the relative importance of quadriceps function, structural change, and psychological status with respect to disability in subjects with knee pain. METHODS 300 men and women with pain and 300 controls without pain (aged 40–79) were seen. Isometric quadriceps strength (MVC) was measured and muscle activation was assessed by twitch superimposition. Disability (Western Ontario McMaster Osteoarthritis Index (WOMAC)) and anxiety and depression were assessed (Hospital Anxiety and Depression Index (HAD)). Radiographs were obtained of the tibiofemoral and patellofemoral joints and total score for osteophyte, narrowing, and sclerosis calculated for each knee. RESULTS Subjects with knee pain had lower voluntary quadriceps strength than those without pain (p<0.005). Quadriceps activation was also lower (p<0.005), but did not fully explain the reduction in strength. When analysed by multiple logistic regression: quadriceps strength (odds ratio 18.8, CI 4.8, 74.1 for MVC ⩽10 kgF); depression (odds ratio 2.4, CI 1.0, 5.5 for HAD score⩾8); and radiographic change (odds ratio 4.1, CI 1.9, 8.6 for radiographic score ⩾4) were independently associated with pain. In those with knee pain, disability was independently associated with quadriceps strength (odds ratio 8.2, CI 1.5, 44.4 for MVC ⩽10 kgF) and depression (odds ratio 6.2, CI 2.1, 18.0 for HAD score⩾8); but not with radiographic score. CONCLUSIONS Quadriceps strength is strongly associated with knee pain and disability in the community, even when activation and psychological factors are taken into account. This has important therapeutic implications.
Near-optimum decoding of product codes: block turbo codes

This paper describes an iterative decoding algorithm for any product code built using linear block codes. It is based on soft-input/soft-output decoders for decoding the component codes so that near-optimum performance is obtained at each iteration. This soft-input/soft-output decoder is a Chase decoder which delivers soft outputs instead of binary decisions. The soft output of the decoder is an estimation of the log-likelihood ratio (LLR) of the binary decisions given by the Chase decoder. The theoretical justifications of this algorithm are developed and the method used for computing the soft output is fully described. The iterative decoding of product codes is also known as the block turbo code (BTC) because the concept is quite similar to turbo codes based on iterative decoding of concatenated recursive convolutional codes. The performance of different Bose-Chaudhuri-Hocquenghem (BCH)-BTCs are given for the Gaussian and the Rayleigh channel. Performance on the Gaussian channel indicates that data transmission at 0.8 dB of Shannon's limit or more than 98% (R/C>0.98) of channel capacity can be achieved with high-code-rate BTC using only four iterations. For the Rayleigh channel, the slope of the bit-error rate (BER) curve is as steep as for the Gaussian channel without using channel state information.
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1 (heat stable antigen). Functional differences among these fractions can be correlated with Ig gene rearrangement status. The largest fraction, lacking S7, consists of pre-B cells whereas the others, expressing S7, include B lineage cells before pre-B. These S7+ fractions, provisionally termed Fr. A, Fr. B, and Fr. C, can differentiate in a stromal layer culture system. Phenotypic alteration during such culture suggests an ordering of these stages from Fr. A to Fr. B to Fr. C and thence to S7- pre-B cells. Using polymerase chain reaction amplification with pairs of oligonucleotide primers for regions 5' of JH1, DFL16.1, and Jk1, we find that the Ig genes of Fr. A are in germline configuration, whereas Fr. B and C are pro-B cell stages with increasing D-J rearrangement, but no V-D-J. Finally, functional analysis demonstrates that the proliferative response to IL-7, an early B lineage growth factor, is restricted to S7+ stages and, furthermore, that an additional, cell contact-mediated signal is essential for survival of Fr. A.
Balancing competition for resources with multiple pest regulation in diversified agroecosystems: a process‐based approach to reconcile diversification and productivity

Abstract Agroecosystem plant diversification can enhance pest biological regulation and is a promising alternative to pesticide application. However, the costs of competition for resources between plants may exceed the benefits gained by pest regulation. To disentangle the interactions between pest regulation and competition, we developed a generic process‐based approach that accounts for the effects of an associated plant and leaf and root pests on biomass production. We considered three crop–plant associations that differ in competition profiles, and we simulated biomass production under wide ranges of both pest regulation rates and resources’ availability. We analyzed outputs to quantify the pest regulation service level that would be required to attain monoculture yield and other production goals. Results showed that pest regulation requirements were highly dependent on the profile of resource interception of the associated plant and on resources’ availability. Pest regulation and the magnitude of competition between plants interacted in determining the balance between nitrogen and radiation uptake by the crop. Our findings suggest that productivity of diversified agroecosystems relative to monoculture should be optimized by assembling plants whose characteristics balance crops’ resource acquisition. The theoretical insights from our study draw generic rules for vegetation assemblage to optimize trade‐offs between pest regulation and production. Our findings and approach may have implications in understanding, theorizing and implementing agroecosystem diversification. By its generic and adaptable structure, our approach should be useful for studying the effects of diversification in many agroecosystems.
Myristoylation is important at multiple stages in poliovirus assembly

The N-terminal glycine of the VP4 capsid subunit of poliovirus is covalently modified with myristic acid (C14 saturated fatty acid). To investigate the function of VP4 myristoylation in poliovirus replication, amino acid substitutions were placed within the myristoylation consensus sequence at the alanine residue (4003A) adjacent to the N-terminal glycine by using site-directed mutagenesis methods. Mutants which replace the alanine residue with a small hydrophobic residue such as leucine, valine, or glycine displayed normal levels of myristoylation and normal growth kinetics. Replacement with the polar amino acid histidine (4003A.H) also resulted in a level of myristoylation comparable to that of the wild type. However, replacement of the alanine residue with aspartic acid (4003A.D) caused a dramatic reduction (about 40 to 60%) in myristoylation levels of the VP4 precursors (P1 and VP0). In contrast, no differences in modification levels were found in either VP0 and VP4 proteins isolated from mature mutant virions, indicating that myristoylation is required for assembly of the infectious virion. The myristoylation levels of the VP0 proteins found in capsid assembly intermediates indicate that there is a strong but not absolute preference for myristoyl-modified subunits during pentamer formation. Complete myristoylation was observed in mature virions but not in assembly intermediates, indicating that there is a selection for myristoyl-modified subunits during stable RNA encapsidation to form the mature virus particle. In addition, even though mutant infectious virions are fully modified, the severe reduction in specific infectivity of both 4003A.D and 4003A.H purified viruses indicates that the amino acid residue adjacent to the N-terminal glycine apparently has an additional role early during viral infection and that mutations at this position induce pleiotropic effects.
Cascaded directional binary pattern for CBIR

Cascaded directional binary pattern (CDBP) using directional extrema pattern is proposed for content based image retrieval in this paper. It avoids the problems associated with standard local binary pattern as well as its many variants. The directional information (0°, 45°, 90° and 135°) along with color information is incorporated in the proposed feature. The feature provides a balanced combination of local and global feature such that fine directional information is not lost. It works on spatial domain so the image characteristics remain intact. Experiments are performed on benchmark image database and improved performance of the proposed feature is justified over many variants of related features i.e. local binary pattern.
Role of Autofluorescence in Inflammatory/Infective Diseases of the Retina and Choroid

Fundus autofluorescence (FAF) has recently emerged as a novel noninvasive imaging technique that uses the fluorescent properties of innate fluorophores accumulated in the retinal pigment epithelium (RPE) to assess the health and viability of the RPE/photoreceptor complex. Recent case reports suggest FAF as a promising tool for monitoring eyes with posterior uveitis helping to predict final visual outcome. In this paper we review the published literature on FAF in these disorders, specifically patterns in infectious and noninfectious uveitis, and illustrate some of these with short case histories.
Retention: The Time-Dependent Nature of Academic and Social Integration. AIR 1992 Annual Forum Paper.

In response to increased attrition at federal service academies including Department of Defense and Coast Guard Academies, a multidimensional study was conducted of proposed theoretical longitudinal attrition models. The primary goal was to determine if persisters and resignees at the Coast Guard Academy could be differentiated based on a multidimensional measure of social and academic integration and to determine if the effect of such a measure was time-dependent. The study sample consisted of 281 cadets who entered the Coast Guard Academy class of 1991 and remained at the end of the fall freshman term. Measures of academic and social integration included grade-point averages, adaptability for service ratings, officer evaluation scores, conduct ratings, and dates of resignation. Results of the study suggest that cadets' sense of integration may be viewed as evolving over time and that measures of integration have their most profound effects in the immediate subsequent time period, for instance, fall freshman measures provided a practical means to discriminate between persisters and resignees only during the time period immediately following their reporting. The overall conclusion of the study was that the measures of social and academic integration are time-dependent, as the ability to predict group membership utilizing the vector of academic and social integration outcomes wanes with time. Included are 2 figures, 5 tables, and 25 references. (JB) *********************************************************************** AepioaucLlons suppiieo oy LoRS are une best Mat can be made from the original document. *********************************************************************** 7,4 RETENTION: THE TIME-DEPENDENT NATURE OF ACADEMIC AND SOCIAL INTEGRATION
A Methyltransferase Targeting Assay Reveals Silencer-Telomere Interactions in Budding Yeast

ABSTRACT We have designed a modified version of the Dam identification technique and used it to probe higher-order chromatin structure in Saccharomyces cerevisiae. We fused the bacterial DNA methyltransferase Dam to the DNA-binding domain of TetR and targeted the resulting chimera to Tet operators inserted in the yeast genome at the repressed locus HML. We then monitored the methylation status of HML and other sequences by a quantitative technique combining methylation-sensitive restriction and real-time PCR. As expected, we found that TetR-Dam efficiently methylated HML in cis. More strikingly, when TetR-Dam was present at HML, we observed increased methylation in the III-L subtelomeric region but not in intervening sequences. This effect was lost when the HML silencers were inactivated by mutations. When the HM silencers and the Tet operators were transferred to a plasmid, strong methylation was clearly observed not only in the III-L subtelomeric region but also at other telomeres. These data indicate that HM silencers can specifically associate with telomeres, even those located on different chromosomes.
Taser Dart-to-Heart Distance That Causes Ventricular Fibrillation in Pigs

Electromuscular incapacitating devices (EMDs), such as Tasers, deliver high current, short duration pulses that cause muscular contractions and temporarily incapacitate the human subject. Some reports suggest that EMDs can kill. To help answer the question, "Can the EMD directly cause ventricular fibrillation (VF)? ," ten tests were conducted to measure the dart-to-heart distance that causes VF in anesthetized pigs [mass=64 kgplusmn6.67 standard deviation (SD)] for the most common X26 Taser. The dart-to-heart distance that caused VF was 17 mmplusmn6.48 (SD) for the first VF event and 13.7 mmplusmn6.79 (SD) for the average of the successive VF events. The result shows that when the stimulation dart is close enough to the heart, X26 Taser current will directly trigger VF in pigs. Echocardiography of erect humans shows skin-to-heart distances from 10 to 57 mm (dart-to-heart distances of 1-48 mm). These results suggest that the probability of a dart on the body landing in 1 cm2 over the ventricle and causing VF is 0.000172
Blockchain Technology: Applications in Health Care

Blockchain technology has gained substantial attention in recent years with increased interest in several diverse fields, including the healthcare industry. Blockchain offers a secure, distributed database that can operate without a central authority or administrator. Blockchain uses a distributed, peer-to-peer network to make a continuous, growing list of ordered records called blocks to form a digital ledger. Each transaction, represented in a cryptographically signed block, is then automatically validated by the network itself. Blockchain has also garnered interest as a platform to improve the authenticity and transparency of healthcare data through many use cases, from maintaining permissions in electronic health records (EHR) to streamlining claims processing. In this article, we describe the basics of blockchain and illustrate current and future applications of this technology within the healthcare industry. Bitcoin, a cryptocurrency and payment system first introduced in 2008, is one of the most well-known implementations of blockchain.1 The transfer of digital assets, such as bitcoin, within a blockchain is initiated when a seller or payer submits a transaction (Figure [A]). 2 These transactions are broadcasted to every peer connected to the blockchain network where clients, called miners, use a cryptographic algorithm to validate the transaction. This validation solves 2 key problems that previously existed with digital currency exchange: ensuring that the digital asset exists and that it has not already been spent. A transaction is said to be valid if a miner deems it is well formed (the input and output contain only the fields that are defined in the protocol), and the outputs it attempts to transfer exist. Miners are not certified and can be anyone who volunteers to invest their resources. The incentive for miners comes in the form of the bitcoin, which are generated and rewarded to the miners for every block of transactions validated. …
Virtual medical model modificiation with Laplacian system

This paper challenges the difficult problem of building accurate virtual medical models. We design an efficient system and method to modify existing three dimensional (3D) human medical models to obtain more accurate ones for different persons in real time. Our presented system can be constructed as a linear system, and this linear system can be solved by computer in real time.
Fast and Robust Memory Reclamation for Concurrent Data Structures

In concurrent systems without automatic garbage collection, it is challenging to determine when it is safe to reclaim memory, especially for lock-free data structures. Existing concurrent memory reclamation schemes are either fast but do not tolerate process delays, robust to delays but with high overhead, or both robust and fast but narrowly applicable. This paper proposes QSense, a novel concurrent memory reclamation technique. QSense is a hybrid technique with a fast path and a fallback path. In the common case (without process delays), a high-performing memory reclamation scheme is used (fast path). If process delays block memory reclamation through the fast path, a robust fallback path is used to guarantee progress. The fallback path uses hazard pointers, but avoids their notorious need for frequent and expensive memory fences. QSense is widely applicable, as we illustrate through several lock-free data structure algorithms. Our experimental evaluation shows that QSense has an overhead comparable to the fastest memory reclamation techniques, while still tolerating prolonged process delays.
Cellular mechanisms of myocardial infarct expansion.

Infarct expansion is acute regional dilatation and thinning of the infarct zone. There are several possibilities for the mechanism of this alteration in cardiac shape: thinning could be caused by 1) cell rupture, 2) a reduction in the intercellular space, or 3) stretching of myocytes or 4) slippage of groups of myocytes so that less cells are distributed across the wall. To determine the relative contributions of these cellular mechanisms of wall thinning and dilatation, detailed study of transverse histological sections of rat hearts with infarct expansion was performed 1, 2, and 3 days after coronary ligation. The number of cells across the wall was determined in six regions within, adjacent to, and remote from the infarct. Cell counting was performed so that the total number of cells across the wall and the number of cells per unit length (cell density) across the wall were determined. The transmural cell count and the cell density were correlated with the wall thickness in each region. Myocyte cross-sectional areas and sarcomere lengths were also measured. The results from the infarct expansion hearts were compared with those of sham-operated control hearts that had been similarly analyzed. To ensure that mechanisms identified in the rat were applicable to human infarct expansion, five hearts from patients who died within 3 days of infarction and two hearts from patients without coronary disease were studied histologically in a similar fashion. Wall thinning occurred in all regions of the rat infarct expansion hearts compared with controls (p less than 0.0001) but, as expected, was most pronounced in the infarct zone. A decrease in the number of cells across the wall accompanied the wall thinning at each site (p less than 0.0001), and this change in cell number was highly correlated with the changes in wall thickness (r = 0.915, p less than 0.001). Cell density increased from controls only within the infarct zone (p less than 0.001) and accounted for at most 20% of the thinning in that region. The change in cell density was attributable to both cell stretch (measured by increased sarcomere length and decreased myocyte cross-sectional area) and a decrease in the intercellular space. A similar strong correlation between wall thinning and decreased number of cells across the wall was identified in the human hearts (r = 0.94, p less than 0.001). (ABSTRACT TRUNCATED AT 250 WORDS)
Mathematical models of vegetation pattern formation in ecohydrology

Highly organized vegetation patterns can be found in a number of landscapes around the world. In recent years, several authors have investigated the processes underlying vegetation pattern formation. Patterns that are induced neither by heterogeneity in soil properties nor by the local topography are generally explained as the result of spatial self‐organization resulting from “symmetry‐breaking instability” in nonlinear systems. In this case, the spatial dynamics are able to destabilize the homogeneous state of the system, leading to the emergence of stable heterogeneous configurations. Both deterministic and stochastic mechanisms may explain the self‐organized vegetation patterns observed in nature. After an extensive analysis of deterministic theories, we review noise‐induced mechanisms of pattern formation and provide some examples of applications relevant to the environmental sciences.
Wireless capacity with oblivious power in general metrics

The capacity of a wireless network is the maximum possible amount of simultaneous communication, taking interference into account. Formally, we treat the following problem. Given is a set of links, each a sender-receiver pair located in a metric space, and an assignment of power to the senders. We seek a maximum subset of links that are feasible in the SINR model: namely, the signal received on each link should be larger than the sum of the interferences from the other links. We give a constant-factor approximation that holds for any length-monotone, sub-linear power assignment and any distance metric. We use this to give essentially tight characterizations of capacity maximization under power control using oblivious power assignments. Specifically, we show that the mean power assignment is optimal for capacity maximization of bi-directional links, and give a tight θ(log n)-approximation of scheduling bi-directional links with power control using oblivious power. For uni-directional links we give a nearly optimal O(log n + log log Δ)-approximation to the power control problem using mean power, where Δ is the ratio of longest and shortest links. Combined, these results clarify significantly the centralized complexity of wireless communication problems.
Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum fibrogenesis marker, YKL-40, in patients with HCV-associated liver disease.

AIM To evaluate the clinical utility of serum fibrosis markers, including YKL-40, in patients with HCV-associated liver disease. METHODS A total of 109 patients with HCV-associated liver disease were enrolled. We measured serum type IV collagen, amino-terminal peptide of type III procollagen (PIIIP), hyaluronic acid (HA), YKL-40 levels and biochemical. Parameters by RIA or ELISA. Eighty-eight patients underwent liver biopsy, and 67 of 109 patients received interferon (IFN) therapy. We also investigated the relationship between the concentrations of serum fibrosis markers and histological fibrosis scores (METAVIR), and evaluated the changes of the levels of fibrosis markers before and after the IFN therapy. RESULTS The increase in serum levels of all markers, particularly HA, was correlated with the progression of liver fibrosis (for type IV collagen, F = 9.076, P<0.0001; for PIIIP, F = 9.636, P<0.0001; for HA, F = 13.128, P<0.0001; and for YKL-40, F = 8.016, P<0.0001). YKL-40 had strong correlation with HA (r = 0.536, P<0.0001). Based on the receiver operating curve (ROC), the ability of serum HA exceeded the abilities of other serum markers to determine fibrosis score 4 from fibrosis score 0-3 (AUC = 0.854). While YKL-40 was superior to other fibrosis markers for predicting severe fibrosis (F2-F4) from mild fibrosis (F0-F1) (YKL-40, AUC = 0.809; HA, AUC = 0.805). After IFN therapy, only YKL-40 values significantly decreased not only in the responder group, but also in the nonresponder group (P = 0.03). CONCLUSION YKL-40 may be a useful non-invasive serum marker to estimate the degree of liver fibrosis and to evaluate the efficacy of IFN therapies in patients with HCV-associated liver disease.