Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors

ABSTRACT Monoclonal antibodies (mAbs) have become a successful therapeutic approach in cancer. However, some patients do not achieve long-term clinical benefit and most mAbs only exert modest effects as monotherapies. Therefore, combinations with chemotherapy are currently being investigated. Emerging studies have shown a synergistic therapeutic effect of PARP inhibitors and mAbs in cancer. PARP enzymes catalytically cleave β-NAD+ and transfer the ADP-ribose moiety to acceptor proteins, modifying their function. In here, we update recent data about the therapeutic effect of the combination of PARP inhibitors with mAbs in cancer treatment and discuss the molecular mechanisms involved in this synergy.
Comparative Neuroanatomy and Genomics of hugin and Pheromone Biosynthesis Activating Neuropeptide (PBAN)

The Drosophila hugin gene encodes a prepropeptide that can potentially generate several neuropeptides.1 The gene is expressed in 20 cells of the subesophageal ganglion (SOG) that are involved in modulating feeding behavior.2 One of the hugin neuropeptides shares homology with mammalian neuromedin U8 (NmU8), which has been shown to regulate feeding behavior in rodents.3,4 Recent clonal analysis indicated that each hugin expressing neuron projects to one of four main targets: the protocerebrum, the ventral nerve cord, the pharynx and the corpora cardiaca.5 In addition all hugin neurons send short neurites to a novel region ventro-lateral to the foramen, which we suggested could be the tritocerebrum. In this short article, we discuss two specific issues brought up by these analyses. One concerns the polarity of hugin neurons. The other is an evolutionary perspective on the processing of hugin neuropeptides in light of new data from mass spectrometric and genomic analyses.
A Laboratory Comparison of Uniform and Discriminative Price Auctions for Reducing Non-point Source Pollution

Auctions allow regulators to identify land management changes with substantial environmental benefit and low opportunity cost. This paper reports an experiment in which seller subjects compete in sealed-offer auctions to obtain part of a fixed budget allocated by the experimenter-regulator to subsidize pollution abatement. One treatment employs uniform-price auction rules, whereas another treatment employs discriminative price auction rules. We find that most offers in the uniform-price auction are within 2% of cost, whereas most offers in the discriminative price auction are at least 8% greater than cost. Nevertheless, the discriminative-price auction has superior overall market performance. (JEL C91, Q15)
2 Global sensitivity , ANOVA and Sobol ’ indices

Global sensitivity analysis measures the importance of some input variables to a function f by looking at the impact on f of making large random perturbations to subsets of those variables. Using measures like those of Sobol' we can attribute importance to input variables based on the extent to which they help predict the target function f. There is a longstanding literature in economics and game theory that considers how to attribute the value of a team effort to individual members of that team. The primary result, known as Shapley value, is the unique method satisfying some intuitively necessary criteria. In this paper we find the Shapley value of individual variables when we take 'variance explained' as their combined value. The result does not match either of the usual Sobol' indices. It is instead bracketed between them, for variance explained or indeed any totally monotone game. Because those indices are comparatively easy to compute, Sobol' indices provide effectively computable bounds for the Shapley value.
Recent advances in the management of acute bronchiolitis

Acute bronchiolitis is characterized by acute wheezing in infants or children and is associated with signs or symptoms of respiratory infection; it is rarely symptomatic in adults and the most common etiologic agent is respiratory syncytial virus (RSV). Usually it does not require investigation, treatment is merely supportive and a conservative approach seems adequate in the majority of children, especially for the youngest ones (<3 months); however, clinical scoring systems have been proposed and admission in hospital should be arranged in case of severe disease or a very young age or important comorbidities. Apnea is a very important aspect of the management of young infants with bronchiolitis. This review focuses on the clinical, radiographic, and pathologic characteristics, as well as the recent advances in management of acute bronchiolitis.
s-Triazines as nitrogen sources for bacteria

Isolation of bacteria able to utilize s-triazines as the sole and limiting nitrogen sources for growth is described. Three strains of Pseudomonas (A, D, and F) and two strains of Klebsiella pneumoniae (90 and 99) were examined. Strains D and F utilized N-ethylammelide, N-isopropylammelide, ammeline, ammelide, cyanuric acid, and ammonium ion as nitrogen sources. Strain A utilized melamine, ammeline, ammelide, cyanuric acid, ammonium ion, and deaminated N-ethylammeline and N-isopropylammeline. Strains 90 and 99 utilized ammelide, cyanuric acid, and ammonium ion. Growth yields of strains were independent of the nitrogen source, and specific growth rates with s-triazines were similar to those with ammonium ion as the nitrogen source (-0.3-0.6 h-l). Suspensions of nongrowing cells generally gave quantitative yields of ammonium ion from s-triazines, and ring carbon atoms were released as carbon dioxide. N-Alkylammelines in mixtures of strains A and D were quantitatively degraded to ammonium ion.
Strong Duality in Nonconvex Quadratic Optimization with Two Quadratic Constraints

We consider the problem of minimizing an indefinite quadratic function subject to two quadratic inequality constraints. When the problem is defined over the complex plane we show that strong duality holds and obtain necessary and sufficient optimality conditions. We then develop a connection between the image of the real and complex spaces under a quadratic mapping, which together with the results in the complex case lead to a condition that ensures strong duality in the real setting. Preliminary numerical simulations suggest that for random instances of the extended trust region subproblem, the sufficient condition is satisfied with a high probability. Furthermore, we show that the sufficient condition is always satisfied in two classes of nonconvex quadratic problems. Finally, we discuss an application of our results to robust least squares problems.
Alternative networks for solving the traveling salesman problem and the list-matching problem

The authors demonstrate that Hopfield-type networks can find reasonable solutions to the traveling salesman problem (TSP) and the optimal list-matching problem (LMP). They show how to avoid the difficulties encountered by G.V. Wilson and G.S. Pawley (1988) by using a modified energy functional which yields better solutions to the TSP than J.J. Hopfield and D.W. Tank's (1985) original formulation. In addition, two fixed-parameter networks are described, one for the TSP and the other for the LMP. The performance of the network for the TSP is comparable to the performance of the modified energy functional formulation, while the network for the list-matching problem is shown to perform better than a simple heuristic method. A major feature of these two networks is that the problem-dependent cost data are contained entirely in the linear term of the energy functional-the quadratic part contains only constraint information. This feature has the advantage that all costs can be presented to the network as inputs rather than as connection weights, much reducing hardware complexity. <<ETX>>
Need for a three‐focused approach to nonalcoholic fatty liver disease

We read with interest the reviews by Ghouri et al. and Martinez et al. Ghouri et al. analyzed the association of nonalcoholic fatty liver disease (NAFLD) with cardiovascular disease (CVD) and concluded that although a diagnosis of NAFLD should prompt diabetes screening, it is insufficient for considering patients to be at high risk for CVD. Martinez et al. evaluated noninvasive methods for assessing liver fibrosis and recommended that those tests with the highest diagnostic accuracy be validated against liver biopsy to facilitate their implementation in clinical practice. We meta-analyzed prospective data regarding the natural history of NAFLD and studies assessing the diagnostic accuracy of noninvasive methods for liver disease severity against liver biopsy in NAFLD, and we reached the following conclusions:
Microstructure Evolution Characterization of Multi-Pass Hot Rolling Simulation of Nb-Ti Microalloyed Steel

In this study, a improved mathematical model was developed for Nb-Ti microalloyed steel during hot rolling simulation. Using the compression test, the dynamic and static recrystallization characteristics of Nb-Ti microalloyed steel were studied. Though multi-pass hot rolling simulation, it is found that the recrystallization during hot rolling can play an important role, it can make the mean flow stress lower and refine the grains. And respective comparison between calculated and measured data of microstructure showed some of the validation of the built model. Meanwhile, the evolution characteristic of average austenite grain size during hot rolling can be achieved by theoretical model and experiment.
Geometry-aware direction field processing

Many algorithms in texture synthesis, nonphotorealistic rendering (hatching), or remeshing require to define the orientation of some features (texture, hatches, or edges) at each point of a surface. In early works, tangent vector (or tensor) fields were used to define the orientation of these features. Extrapolating and smoothing such fields is usually performed by minimizing an energy composed of a smoothness term and of a data fitting term. More recently, dedicated structures (N-RoSy and N-symmetry direction fields ) were introduced in order to unify the manipulation of these fields, and provide control over the field's topology (singularities). On the one hand, controlling the topology makes it possible to have few singularities, even in the presence of high frequencies (fine details) in the surface geometry. On the other hand, the user has to explicitly specify all singularities, which can be a tedious task. It would be better to let them emerge naturally from the direction extrapolation and smoothing. This article introduces an intermediate representation that still allows the intuitive design operations such as smoothing and directional constraints, but restates the objective function in a way that avoids the singularities yielded by smaller geometric details. The resulting design tool is intuitive, simple, and allows to create fields with simple topology, even in the presence of high geometric frequencies. The generated field can be used to steer global parameterization methods (e.g., QuadCover).
Generating queries and replies during information-seeking interactions

Analysis of naturally occurring information-seeking dialogues indicates that they usually consist of a number of distinct discourse segments, such as a greeting segment, a request issued by a user, an optional clarification segment, a transfer of information segment and a final closing segment. The clarification interaction is often initiated by the information provider and it may be due to one of the following reasons: (1) there is confusion regarding the user's intentions, (2) there is insufficient information to formulate a plan to satisfy a recognized intention, or (3) there is difficulty in formulating a plan that satisfies a recognized intention. Once the information provider determines the user's intention and formulates a plan to achieve this intention, the information transfer phase is initiated to inform the user about the proposed plan.In this paper, we present a mechanism for generating queries during the clarification stage and answers during the information transfer stage. Given a hierarchical representation of the alternatives possibly intended by a user and the probabilities of these alternatives, our mechanism determines the hierarchy level at which a query must be directed and the query to be posed in order to determine the alternative intended by the user. Once the user's intentions are ascertained, the mechanism determines whether additional information is required and the manner in which queries may be posed to acquire this information. When a user's intentions cannot be satisfied by means of a single plan, our mechanism enters into a negotiation process to alter the user's specifications until a valid plan is formulated. In the final stages of the interaction, the mechanism determines the information to be transferred and generates an answer to effect the transfer. The mechanisms for negotiation and for the generation of queries and answers described in this paper have been implemented in a system calledRADAR, a computerized information providing system that functions as a travel agent.
Bidi cigarettes: An emerging threat to adolescent health.

The bidi cigarette, or bidi, is a dangerous tobacco product that has rapidly been gaining popularity in the United States during the past few years, particularly with adolescents. Bidis, which are imported from India and sold in convenience stores and gas stations, are being marketed as a new, safe, and natural alternative to regular cigarettes. The cured flakes and dust of dark tobacco leaves are hand-rolled in dried tendu leaves (a broad-leafed plant native to India) and tied at both ends with colorful thread. The unfiltered final product is a small, slim cigarette whose appearance resembles that of a marijuana cigarette. Various flavorings, including vanilla, chocolate, strawberry, and root beer, are added to mask the poor quality of the tobacco. Bidis are sold for around $2 for a pack of 20, which is approximately half the price of regular cigarettes. Walk into a convenience store in a major American city such as New York, and one will likely find bidis displayed behind the counter, beside a cache of Beanie Babies. However, unlike their furry shelf companions of equally innocuous-sounding name, bidis are anything but harmless and are unlikely to disappear any time soon.
A FGFR-2 Inhibitor, Ki23057, Evaluated as a Novel VEGFR-2 KinaseInhibitor

The aim of this study was to clarify the ability of a FGFR-2 inhibitor, Ki23057, to inhibit the VEGFR-2 signaling pathway which was a valuable approach in the treatment of cancers. An efficient and convenient synthetic route to Ki23057 has been developed utilizing a key onepot method. Its biological activities as VEGFR-2 kinase inhibitors were evaluated by immunohistochemistry. The results exhibited that the Ki23057 has potent inhibitory activities against VEGFR-2 tyrosine kinase. Docking simulation was performed to demonstrate that Ki23057 is a potential agent for VEGFR-2 cancer therapy.
Optics in data center: Improving scalability and energy efficiency

Interconnection networks within modern data centers suffer from bandwidth and scalability limitations, and important power consumption. Optical switching solutions can help to overcome such issues when properly designed and optimized. This paper discusses three areas of improvement beyond state of the art: i) the use of more energy-efficient optical devices to realize high-capacity and energy-efficient optical space switches; ii) the enhancement of their scalability by combining space switching with time switching into a space-time interconnection network architecture (STIA); iii) the planning of an energy-efficient STIA-based network meeting data center bisection bandwidth requirements. Performance assessment shows that i) by combining different switching devices in the same space switch, up to 90% of the power can be saved with respect to conventional SOA-based space switches; ii) STIA allows scalability to increase by a factor of 8, thanks to the combined use of space and time switching domains, while limiting the energy per bit; iii) STIA allows the realization of data center topologies, such as folded Clos and flattened butterfly, whose optimized design can lead to power saving up to 50% with respect to an energy unaware design.
Regulation of gene expression and its role in long-term memory and synaptic plasticity.

Histories of science yet to be written will view the latter half of this century as the Age of Molecular Genetics. From a flash of insight that yielded the double helix (1) to the first genetic clone of a mammal (2), molecular genetics has invaded every aspect of biological research. Initially, this molecular-genetic onslaught was limited to species, such as bacteria, yeast, nematodes, and fruit flies, whose size and life cycle constituted an economy of scale that was advantageous to breeding (3). With the introduction of gene-knockout techniques to mice (4), however, molecular genetics now is storming mammals (5, 6). In the broadest sense, the recent paper by Guzowski and McGaugh (7) represents a vanguard of this invasion. By using antisense oligonucleotides as “pharmaceutical” disruptors of gene expression, they have liberated molecular genetics from breeding. Endogenous regulation of gene expression has been outflanked by exogenous control.
Humoral immune response in chinchillas to the capsular polysaccharides of Streptococcus pneumoniae

Vaccines made from the capsular polysaccharides of Streptococcus pneumoniae have been shown to reduce the incidence of pneumococcal disease in certain populations and have recently been evaluated for their ability to elicit protection against experimental pneumococcal otitis media in a chinchilla model. In this study, chinchillas were vaccinated with a dodecavalent preparation of pneumococcal capsular polysaccharides (PCP) to obtain more information on the immunogenicity of these polysaccharide antigens. All 12 PCP types elicited an antibody response, but the optimum PCP dose and the kinetics of the antibody response varied among types. Immunological paralysis was demonstrated with an immunogenic dose of PCP after primary immunization with a large PCP dose (25 micrograms or more). Pertussis vaccine acted as neither an immunoadjuvant nor an immunosuppressant in the serum antibody response to type 7F PCP in chinchillas.
Ancient genomics

The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.
Tracing Tuples Across Dimensions: A Comparison of Scatterplots and Parallel Coordinate Plots

One of the fundamental tasks for analytic activity is retrieving (i.e., reading) the value of a particular quantity in an information visualization. However, few previous studies have compared user performance in such value retrieval tasks for different visualizations. We present an experimental comparison of user performance (time and error distance) across four multivariate data visualizations. Three variants of scatterplot (SCP) visualizations, namely SCPs with common vertical axes (SCP‐common), SCPs with a staircase layout (SCP‐staircase), and SCPs with rotated axes between neighboring cells (SCP‐rotated), and a baseline parallel coordinate plots (PCP) were compared. Results show that the baseline PCP is better than SCP‐rotated and SCP‐staircase under all conditions, while the difference between SCP‐common and PCP depends on the dimensionality and density of the dataset. PCP shows advantages over SCP‐common when the dimensionality and density of the dataset are low, but SCP‐common eventually outperforms PCP as data dimensionality and density increase. The results suggest guidelines for the use of SCPs and PCPs that can benefit future researchers and practitioners.
Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population

AbstractChronic obstructive pulmonary disease (COPD) is a possible risk factor for cardiovascular disease. The association of COPD with the pathogenicity of infection with Chlamydia pneumoniae and Mycoplasma pneumoniae is controversial. We conducted a cross-sectional study to clarify the association between atypical pneumoniae seropositivity and COPD in a general population. We also investigated genetic polymorphisms conferring susceptibility to a pneumonia titer.The study included 9040 Japanese subjects (54 ± 13 years). COPD was defined as a ratio of forced expiratory volume in 1 second to forced vital capacity of less than 70%. Serum levels of IgA and IgG antibodies to C pneumoniae were determined using an enzyme-linked immunoassay, and M pneumoniae seropositivity was assessed by a particle agglutination test.Subjects seropositive for C pneumoniae (26.1%) had a higher prevalence of COPD (seropositive, 5.8%; seronegative, 3.1%; P < 0.001) after adjustment for age, sex, height, weight, and smoking status. The association between M pneumoniae seropositivity (20.4%) and COPD was also significant in covariate-adjusted analysis (P < 0.001). A genome-wide association analysis of the C pneumoniae IgA index identified a susceptible genotype (rs17634369) near the IKZF1 gene, and the seropositive rate of C pneumoniae significantly differed among genotypes (AA, 22.5; AG, 25.3; GG, 29.7%, P < 0.001). On multiple regression analysis, seropositivity for both C pneumoniae (odds ratio = 1.41, P = 0.004) and M pneumoniae (odds ratio = 1.60, P = 0.002) was an independent determinant for COPD, while no direct association was found with the rs17634369 genotype.Seropositivity for both C pneumoniae and M pneumoniae is an independent risk factor for COPD in the general population.