Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model

ABSTRACT Out of an estimated 31,100 cases since their discovery in 1976, ebolaviruses have caused approximately 13,000 deaths. The vast majority (∼11,000) of these occurred during the 2013-2016 West African epidemic. Three out of five species in the genus are known to cause Ebola Virus Disease in humans. Several monoclonal antibodies against the ebolavirus glycoprotein are currently in development as therapeutics. However, there is still a paucity of monoclonal antibodies that can cross-react between the glycoproteins of different ebolavirus species, and the mechanism of these monoclonal antibody therapeutics is still not understood in detail. Here, we generated a panel of eight murine monoclonal antibodies (MAbs) utilizing a prime-boost vaccination regimen with a Zaire ebolavirus glycoprotein expression plasmid followed by infection with a vesicular stomatitis virus expressing the Zaire ebolavirus glycoprotein. We tested the binding breadth of the resulting monoclonal antibodies using a set of recombinant surface glycoproteins from Reston, Taï Forest, Bundibugyo, Zaire, Sudan, and Marburg viruses and found two antibodies that showed pan-ebolavirus binding. An in vivo Stat2−/− mouse model was utilized to test the ability of these MAbs to protect from infection with a vesicular stomatitis virus expressing the Zaire ebolavirus glycoprotein. Several of our antibodies, including the broadly binding ones, protected mice from mortality despite lacking neutralization capability in vitro, suggesting their protection may be mediated by Fc-FcR interactions. Indeed, three antibodies displayed cellular phagocytosis and/or antibody-dependent cell-mediated cytotoxicity in vitro. Our antibodies, specifically the two identified cross-reactive monoclonal antibodies (KL-2E5 and KL-2H7), might add to the understanding of anti-ebolavirus humoral immunity. IMPORTANCE This study describes the generation of a panel of novel anti-ebolavirus glycoprotein monoclonal antibodies, including two antibodies with broad cross-reactivity to all known ebolavirus species. The antibodies were raised using a heterologous DNA-viral vector prime-boost regimen, resulting in a high proportion of cross-reactive antibodies (25%). Similar vaccination regimens have been used successfully to induce broad protection against influenza viruses in humans, and our limited data indicate that this might be a useful strategy for filovirus vaccines as well. Several of our antibodies showed protective efficacy when tested in a novel murine challenge model and may be developed into future therapeutics.
Glycerol adsorption energy onto Pt and PtSn (001) surfaces using density functional theory and vdW corrections

The glycerol is a very versatile molecule that has a wide applicability, among them the promising use as a fuel for fuel cells, in which glycerol is oxidized to provide protons and electrons. The adsorption of this molecule on the surface of the catalyst (usually a metal or metal alloy) is a fundamental step for the oxidation of this alcohol. Therefore, in this work, the glycerol adsorption on Pt and PtSn surfaces in plane 001 was studied using the density functional theory with and without the van der waals correction to perform computational computations in order to better understand the adsorption process of glycerol on such surfaces.
Direct and indirect climate controls predict heterogeneous early-mid 21st century wildfire burned area across western and boreal North America

Predicting wildfire under future conditions is complicated by complex interrelated drivers operating across large spatial scales. Annual area burned (AAB) is a useful index of global wildfire activity. Current and antecedent seasonal climatic conditions, and the timing of snowpack melt, have been suggested as important drivers of AAB. As climate warms, seasonal climate and snowpack co-vary in intricate ways, influencing fire at continental and sub-continental scales. We used independent records of seasonal climate and snow cover duration (last date of permanent snowpack, LDPS) and cell-based Structural Equation Models (SEM) to separate direct (climatic) and indirect (snow cover) effects on relative changes in AAB under future climatic scenarios across western and boreal North America. To isolate seasonal climate variables with the greatest effect on AAB, we ran multiple regression models of log-transformed AAB on seasonal climate variables and LDPS. We used the results of multiple regressions to project future AAB using GCM ensemble climate variables and LDPS, and validated model predictions with recent AAB trends. Direct influences of spring and winter temperatures on AAB are larger and more widespread than the indirect effect mediated by changes in LDPS in most areas. Despite significant warming trends and reductions in snow cover duration, projected responses of AAB to early-mid 21st century are heterogeneous across the continent. Changes in AAB range from strongly increasing (one order of magnitude increases in AAB) to moderately decreasing (more than halving of baseline AAB). Annual wildfire area burned in coming decades is likely to be highly geographically heterogeneous, reflecting interacting regional and seasonal climate drivers of fire occurrence and spread.
Incremental Hospital Cost and Length-of-Stay Associated With Treating Adverse Events Among Medicare Beneficiaries Undergoing Lumbar Spinal Fusion During Fiscal Year 2013

Study Design. A retrospective study. Objectives. To report the incremental hospital resource consumption associated with treating selected adverse events experienced by Medicare beneficiaries undergoing a two- or three-level lumbar spinal fusion. Summary of Background Data. Hospitals are increasingly at financial risk for the incremental resources consumed in treating patients experiencing adverse events because of public and private third-party payers’ efforts to base hospital reimbursement on “pay for performance” measures. However, little is known about average incremental resources consumed in treating patients experiencing adverse events following lumbar spinal fusions. Methods. The 2013 fiscal year Medicare Provider Analysis and Review file was used to identify 83,658 Medicare beneficiaries who underwent two- or three vertebrae-level lumbar spinal fusion. International Classification of Diseases-9th—Clinical Modification diagnostic and procedure codes were used to identify the frequencies of nine adverse events. This study estimated both the observed and risk-adjusted incremental hospital resources consumed (cost and length of stay [LOS]) in treating Medicare beneficiaries experiencing each adverse event. Results. Overall, 17.7% of Medicare beneficiaries undergoing lumbar spinal fusion experienced at least one of the study's adverse events. Medicare beneficiaries experiencing any complication consumed significantly more hospital resources (incremental cost of $8911) and had longer LOS (incremental stays of 5.7 days). After adjusting for patient demographics and comorbid conditions, incremental cost of treating adverse events ranged from a high of $32,049 (infection) to a low of $9976 (transfusion). Conclusion. Adverse events frequently occur and add substantially to the hospital resource costs of patients undergoing spinal fusion. Shared decision-making instruments should clearly provide these risk estimates to the patient before surgical consideration. Investment in activities that have been shown to reduce specific adverse events is warranted, and this project may allow health systems to prioritize performance improvement areas. Level of Evidence: 3
Mamontovaya Kurya : an enigmatic , nearly 40 000 years old Paleolithic site in

There is a need to fill in the gap in the archeological record from high latitudes to increase our understanding of early human colonization and adaptation to the arctic environment. Until recently it was a common opinion that the Eurasian Arctic was not occupied by humans until the final stage of the last Ice Age some 13-14 000 years ago (Hoffecker et al., 1993; Powers, 1996). However, the discovery of the Paleolithic site Mamontovaya Kurya in the Russian Arctic implies that this view should be reconsidered (Pavlov et al., 2001). This site, radiocarbon dated to 35-40 000 years BP, is believed to represent the oldest reported evidence of human occupation in the Arctic. In addition to a handful of stone artifacts, an important find was a mammoth tusk with a series of regular marks which were inscribed by humans. In this paper we present an updated documentation of the
Patterns of locomotor regulation during the pole vault approach phase

ABSTRACT A successful approach phase is key to achieving high performances in the pole vault. The aim of this study was to explore the nature of locomotor control patterns during the pole vault approach phase. Fourteen well-trained athletes performed ten jumps which were recorded using 2D video sampling at 200 Hz and analysed. Key kinematics were reconstructed from camera data using a modified 2D-DLT. Patterns of regulation were determined from the standard deviation of footfall locations during the approach phase. These patterns were found to be highly individual but structural differences between those who did and those who did not regulate were identified. Regulation of locomotion was associated with an ability to produce functionally adaptable movement patterns and the consistent achievement of desired performance outcomes. Coaches should include training exercises that require intentional use of regulation to aid athletes in achieving the flexibility to adapt to changing constraints during the approach phase. Athletes should be considered on an individual basis in order to effectively, efficiently and safely improve performance.
A comparative study of hyperelastic constitutive models to characterize the behavior of a polymer used in automotive engines

The global automotive industry faces the challenge of increasing engine efficiency, reducing fuel consumption and the size of them gradually. Not only the engine block must reduce its size, but also other components, requiring more compact and flexible designs using materials such as thermoplastic elastomers. These kinds of materials are used due to their characteristics, such as ability of deformation, durability, recyclability, and its cost/weight ratio. They are able to hold large deformations and they have very good damping characteristics, making them suitable for use in energy dissipation. Characterization of the dynamic mechanical properties of these materials is essential to make a correct analysis and modeling of the behavior of components. Although the constitutive models of these materials are complex due to high deformability, quasi-incompressibility, softening, and time dependent effects, typically, these materials have a mechanical behavior which can be represented by a phenomenological hyperelastic model. While it is easy to fit a model of elastic behavior, set a model for a hyperelastic material is a very complex task, so in practice simplified models are used. This paper proposes a comprehensive comparison of six hyperelastic models to simulate the behavior of Santoprene 101-73 material manufactured by ExxonMobil. The ability of these models to reproduce different types of loading conditions is analyzed through uniaxial tensile data obtained experimentally. The parameters of each of the hyperelastic models are determined by a least-squares fit and then a classification of these six models is established, highlighting those that are most suitable for characterizing the material.
Learning from My Success and from Others' Failure: Evidence from Minimally Invasive Cardiac Surgery

Learning from past experience is central to an organization's adaptation and survival. A key dimension of prior experience is whether an outcome was successful or unsuccessful. Although empirical studies have investigated the effects of success and failure in organizational learning, to date, the phenomenon has received little attention at the individual level. Drawing on attribution theory in psychology, we investigate how individuals learn from their own past experiences with both failure and success and from the experiences of others. For our empirical analyses, we use 10 years of data from 71 cardiothoracic surgeons who completed more than 6,500 procedures using a new technology for cardiac surgery. We find that individuals learn more from their own successes than from their own failures, but they learn more from the failures of others than from others' successes. We also find that individuals' prior successes and others' failures can help individuals overcome their inability to learn from their own failures. Together, these findings offer both theoretical and practical insights into how individuals learn directly from their prior experience and indirectly from the experiences of others. This paper was accepted by Jesper Sorensen, organizations.
Player action recognition in broadcast tennis video with applications to semantic analysis of sports game

Recognition of player actions in broadcast sports video is a challenging task due to low resolution of the players in video frames. In this paper, we present a novel method to recognize the basic player actions in broadcast tennis video. Different from the existing appearance-based approaches, our method is based on motion analysis and considers the relationship between the movements of different body parts and the regions in the image plane. A novel motion descriptor is proposed and supervised learning is employed to train the action classifier. We also propose a novel framework by combining the player action recognition with other multimodal features for semantic and tactic analysis of the broadcast tennis video. Incorporating action recognition into the framework not only improves the semantic indexing and retrieval performance of the video content, but also conducts highlights ranking and tactics analysis in tennis matches, which is the first solution to our knowledge for tennis game. The experimental results demonstrate that our player action recognition method outperforms existing appearance-based approaches and the multimodal framework is effective for broadcast tennis video analysis.
Bilingualism as a strategy to delay the onset of Alzheimer’s disease

The purpose of this study is to explore original studies which provide evidence about the effects of bilingualism on the delay of the onset of dementia, specifically Alzheimer’s disease (AD). A literature review was conducted in the world’s acknowledged databases: Web of Science, Scopus, and MEDLINE. Altogether, 14 original studies focusing on the research topic were detected. These included six prospective cohort studies and eight retrospective studies. Both types of studies suggest different conclusions. The findings from the prospective cohort studies state that there is no association between bilingualism and the delay of the onset of AD, while the retrospective studies claim the opposite. Despite the negative results of the prospective cohort studies, more research should be conducted on bilingualism and its impact on the delay of the onset of AD, since the brain studies have brought positive findings as far as the enhancement of cognitive reserve is concerned.
Sexual assault incidents among college undergraduates: Prevalence and factors associated with risk

Sexual assault on college campuses is a public health issue. However varying research methodologies (e.g., different sexual assault definitions, measures, assessment timeframes) and low response rates hamper efforts to define the scope of the problem. To illuminate the complexity of campus sexual assault, we collected survey data from a large population-based random sample of undergraduate students from Columbia University and Barnard College in New York City, using evidence based methods to maximize response rates and sample representativeness, and behaviorally specific measures of sexual assault to accurately capture victimization rates. This paper focuses on student experiences of different types of sexual assault victimization, as well as sociodemographic, social, and risk environment correlates. Descriptive statistics, chi-square tests, and logistic regression were used to estimate prevalences and test associations. Since college entry, 22% of students reported experiencing at least one incident of sexual assault (defined as sexualized touching, attempted penetration [oral, anal, vaginal, other], or completed penetration). Women and gender nonconforming students reported the highest rates (28% and 38%, respectively), although men also reported sexual assault (12.5%). Across types of assault and gender groups, incapacitation due to alcohol and drug use and/or other factors was the perpetration method reported most frequently (> 50%); physical force (particularly for completed penetration in women) and verbal coercion were also commonly reported. Factors associated with increased risk for sexual assault included non-heterosexual identity, difficulty paying for basic necessities, fraternity/sorority membership, participation in more casual sexual encounters (“hook ups”) vs. exclusive/monogamous or no sexual relationships, binge drinking, and experiencing sexual assault before college. High rates of re-victimization during college were reported across gender groups. Our study is consistent with prevalence findings previously reported. Variation in types of assault and methods of perpetration experienced across gender groups highlight the need to develop prevention strategies tailored to specific risk groups.
Iron deficiency and cognitive functions

Micronutrient deficiencies, especially those related to iodine and iron, are linked to different cognitive impairments, as well as to potential long-term behavioral changes. Among the cognitive impairments caused by iron deficiency, those referring to attention span, intelligence, and sensory perception functions are mainly cited, as well as those associated with emotions and behavior, often directly related to the presence of iron deficiency anemia. In addition, iron deficiency without anemia may cause cognitive disturbances. At present, the prevalence of iron deficiency and iron deficiency anemia is 2%–6% among European children. Given the importance of iron deficiency relative to proper cognitive development and the alterations that can persist through adulthood as a result of this deficiency, the objective of this study was to review the current state of knowledge about this health problem. The relevance of iron deficiency and iron deficiency anemia, the distinction between the cognitive consequences of iron deficiency and those affecting specifically cognitive development, and the debate about the utility of iron supplements are the most relevant and controversial topics. Despite there being methodological differences among studies, there is some evidence that iron supplementation improves cognitive functions. Nevertheless, this must be confirmed by means of adequate follow-up studies among different groups.
Multiregional Tumor Drug-Uptake Imaging by PET and Microvascular Morphology in End-Stage Diffuse Intrinsic Pontine Glioma

Inadequate tumor uptake of the vascular endothelial growth factor antibody bevacizumab could explain lack of effect in diffuse intrinsic pontine glioma. Methods: By combining data from a PET imaging study using 89Zr-labeled bevacizumab and an autopsy study, a 1-on-1 analysis of multiregional in vivo and ex vivo 89Zr-bevacizumab uptake, tumor histology, and vascular morphology in a diffuse intrinsic pontine glioma patient was performed. Results: In vivo 89Zr-bevacizumab measurements showed heterogeneity between lesions. Additional ex vivo measurements and immunohistochemistry of cervicomedullary metastasis samples showed uptake to be highest in the area with marked microvascular proliferation. In the primary pontine tumor, all samples showed similar vascular morphology. Other histologic features were similar between the samples studied. Conclusion: In vivo 89Zr-bevacizumab PET serves to identify heterogeneous uptake between tumor lesions, whereas subcentimeter intralesional heterogeneity could be identified only by ex vivo measurements. 89Zr-bevacizumab uptake is enhanced by vascular proliferation, although our results suggest it is not the only determinant of intralesional uptake heterogeneity.
Friedreich Ataxia: Clinical Report of an Uncommon Point Mutation (R165C)

Introduction: Friedreich ataxia (FRDA) is the most common hereditary ataxia now. It is inherited as an autosomal recessive disease. Most of the patients are homozygotes, with an expansion of a GAA triplet in both alleles of the first intron of the frataxin gene (FXN, 9q13) (95-98% of the patients). The rest of the patients are heterozygotes with an expansion in only one allele and a point mutation in the other. These cases are more difficult to diagnose due to the low prevalence and the needed of enlarge molecular tests. Case Report: An ambulant 42-year-old man was referred to our hospital due to gait instability that had started 7 years ago. A clinical examination showed gait ataxia, areflexia, decrease vibration sense, scoliosis, and pes cavus. Results and Discussion: Laboratory tests, neuroimaging and neurophysiologic studies had been done since then without relevant findings. Somatosensory evoked potentials were also done and described a sensitive axonal neuropathy with an affectation of the posterior columns of the spinal cord. Due findings of 300-350 repetitions of GAA in one allele and the point mutation R165C in the other that confirmed the diagnosis. Conclusion: This case report highlights that, although most patients of Friedreich ataxia are usually homozygotes, there are a small number of patients that are heterozygotes and can have different phenotypes being important to identify them to give genetic counselling and detect new complications that suppose a risk for their lives.
a reaction to Thomas Sheridan's "Musings on Telepresence"

In an initial section, operators' sense of remote presence during teleoperation or use of virtual environment interfaces is analyzed as to what characteristics it should have to qualify it as an explanatory scientific construct. But the implicit goal of designing virtual environment interfaces to maximize presence is itself questioned in a second section in which examples of human-machine interfaces beneficially designed to avoid a strong sense of egocentric presence are cited. In conclusion, it is argued that the design of a teleoperation or virtual environment system should generally focus on the efficient communication of causal interaction. In this view the sense of presence, that is of actually being at t h e simulated or remote workplace, is an epiphenomena of secondary importance for design.