Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrin (cid:98) 2 (CD18)-Mediated Cell Proliferation of HEL Cells on a Hematopoietic-Supportive Bone Marrow Stromal Cell Line, HESS-5 Cells

Cellular interactions between hematopoietic cells and stro- cells play important roles in the proliferation and differentiation of hematopoietic cells. The proliferation of a hu- man erythroleukemia cell line, HEL cells, which can differentiate into macrophage- and megakaryocyte-like cells, and erythroid precursors was dramatically induced on coculture with a hematopoietic-supportive stromal cell line, HESS-5 cells, which can support long-term hematopoiesis in vitro without fetal bovine serum. HEL cells proliferated when they were cocultured with but not without direct cell contact. Because the coculture supernatants with direct cell contact and cytokines such as interleukins and growth factors did not exhibit growth-stimulating activity toward HEL cells, it was suggested that some molecule that has growth-stimulating activity exists on the surface of the cells. Extracellular matrix components such as fibronectin, lami-nin, vitronectin, and collagen did not affect the proliferation of HEL cells. An anti-CD18 monoclonal antibody, which recognizes the common (cid:98) chain of the (cid:98) 2 integrin subfamily, induced dramatic proliferation of HEL cells. Moreover, the proliferation of HEL cells was inhibited by an antisense oligonucleotide of CD18 mRNA. As judged from these obser-vations, the proliferation of HEL cells was mediated by CD18 molecules expressed on HEL cells. On the contrary, the common counter-receptor of the (cid:98) 2 integrin subfamily, intercellular adhesion molecule-1, which is expressed on CHO-K1 cells, did not stimulate the growth of HEL cells. It is known that other counter molecules of the (cid:98) 2 integrin subfamily, such as complement C3bi and fibrinogen, are not produced by stromal cells. These findings suggest that the proliferation of HEL cells may be induced through an interaction between a novel molecule of the (cid:98) 2 integrin subfamily on HEL cells and the counter-receptor on HESS-5 cells. The (cid:98) 2 integrin subfamily may regulate the growth of hematopoietic cells in hematopoiesis in vivo and/or cause the abnormal growth of leukemia cells.
Ovarian suspension for longer than 36 h is necessary for temporary ovarian suspension to fulfil its remit.

multiple births after ART: medical, psychological, social and financial aspects. Hum Reprod 1999;14:2932–2937. Stillman RJ, Richter KS, Jones HW Jr. Refuting a misguided campaign against the goal of single-embryo transfer and singleton birth in assisted reproduction. Hum Reprod 2013;28:2599–2607. Sullivan EA, Wang YA, Hayward I, Chambers GM, Illingworth P, McBain J, Norman RJ. Single embryo transfer reduces the risk of perinatal mortality, a population study. Hum Reprod 2012;27:3609–3615.
Traffic modeling and characterization for UMTS networks

In this paper, we present a synthetic traffic model for the Universal Mobile Telecommunication Systems (UMTS) based on measured trace data. The analysis and scaling process of the measured trace data with respect to different bandwidth classes constitutes the basic concept of the UMTS traffic characterization. Furthermore, we introduce an aggregated traffic model for UMTS networks that is analytically tractable. The key idea of this aggregated traffic model lies in customizing the batch Markovian arrival process (BMAP) such that different packet sizes of IP packets are represented by rewards (ie, batch sizes of arrivals) of the BMAP. The effectiveness of the customized BMAP for modeling UMTS traffic is illustrated using the synthetic traffic model previously presented.
CARING FOR THE CRITICALLY ILL PATIENT Should Immunonutrition Become Routine in Critically Ill Patients ? A Systematic Review of the Evidence

NOSOCOMIAL INFECTION IN critically ill patients is associated with higher morbidity and mortality, prolonged intensive care unit (ICU) and hospital stay, and increased health care costs. Among seriously ill patients, malnutrition has been associated with increased infectious morbidity and prolonged hospital stay. Providing nutrition support has become the standard of care for critically ill patients. Enteral nutrition is preferred to parenteral nutrition for meeting the nutritional needs of critically ill patients with functioning alimentary tracts. Several specific nutrients such as arginine, glutamine, nucleotides, and omega-3 fatty acids, either alone or in combination, have been shown in laboratory and clinical studies to influence nutritional, immunological, and inflammatory parameters. To date, there have been several randomized trials that have evaluated the effect of these immunonutrients on clinically important outcomes. To our knowledge, 2 systematic reviews have already statistically aggregated the results of these randomized clinical trials in critically ill patients. However, methodological limitations of Author Affiliations are listed at the end of this article. Corresponding Author and Reprints: Daren K. Heyland, MD, FRCPC, MSc, Angada 3, Kingston General Hospital, 76 Stuart St, Kingston, Ontario K7L 2V7, Canada (e-mail: dkh2@post.queensu.ca). Caring for the Critically Ill Patient Section Editor: Deborah J. Cook, MD, Consulting Editor, JAMA. Advisory Board: David Bihari, MD; Christian BrunBuisson, MD; Timothy Evans, MD; John Heffner, MD; Norman Paradis, MD. Context Several nutrients have been shown to influence immunologic and inflammatory responses in humans. Whether these effects translate into an improvement in clinical outcomes in critically ill patients remains unclear.
Supplementary Mathematical Methods

We constructed a mathematical model based on individual currents carried by the electrogenic transmembrane proteins in myometrium smooth muscle cell (MSMC). The aim is to analyse in detail the contributions made by these various proteins to the myometrial action potential (MAP). Our approach consists of four basic steps: (i) characterise the potential repertoire of electrogenic proteins by means of expression studies; (ii) model and parametrise each ion channel or pump independently on the basis of independent data obtained from heterologous expression studies in the literature; (iii) characterise all combinations of expression levels of these entities that are consistent with the calcium and membrane potential waveform that we observe in human MSMCs; (vi) select an expression vector based on a parsimony criterion and run a simulation based on these values. The first step is the construction of the complete repertoire of the electrogenic proteins that are potentially expressed in MSMC based on mRNA expression data [1] (Figure D1). The molecular biology yields a list of ion channel subunits that are expressed in MSMC. Since ion channels exist as a various combinations of those subunits, this list generates a sizeable repertoire that may be present in the plasma membrane of the MSMC. The second step is to formulate a mathematical model for every oligomeric channel complex that has been previously attested in the literature and, moreover that is consistent with the subunits in the mRNA expression list [1]. For each conductance, a mathematical model was taken from the literature where available otherwise, a model was formulated on the basis of the available data. Accordingly, the biophysical and kinetic parameters are in some cases adopted directly in the literature and in other cases obtained by means of least-squares fitting to the experimental data on heterologous expression systems as provided by the literature. The gating kinetics of each individual conductance species is represented using either a Hodgkin-Huxley model or a Markov model. The parameters and equations used to describe the kinetics of the individual conductances are listed below.
Joint Group Testing of Time-varying Faulty Sensors and System State Estimation in Large Sensor Networks

The problem of faulty sensor detection is investigated in large sensor networks where the sensor faults are sparse and time-varying, such as those caused by attacks launched by an adversary. Group testing and the Kalman filter are designed jointly to perform real time system state estimation and time-varying faulty sensor detection with a small number of tests. Numerical results show that the faulty sensors are efficiently detected and removed, and the system state estimation performance is significantly improved via the proposed method. Compared with an approach that tests sensors one by one, the proposed approach reduces the number of tests significantly while maintaining a similar fault detection performance.
Internet-based Tele-rehabilitatioon System --Bilateral Tele-control with Variable Time Delay

This paper discussed an Internet-based telerehabilitation sharing system, which aims to achieve the situation where multiple stay home patients in different places can share rehabilitation instruction of one physical therapist at the same time. After the introduction, three main problems are described in this paper. Firstly the stability problem of the master-slave system with variable time delay which is the biggest problem of the tele-control system is focused on, the time delay and its effect to the system is described and the control architecture is proposed; then the operation method of the whole system with single-master and multi-slave is described; After that, the wound-tube actuator and tail-wrist which will be used as slave in the tele-rehabilitation system is introduced
Zhang Neural Network Versus Gradient Neural Network for Solving Time-Varying Linear Inequalities

By following Zhang design method, a new type of recurrent neural network [i.e., Zhang neural network (ZNN)] is presented, investigated, and analyzed for online solution of time-varying linear inequalities. Theoretical analysis is given on convergence properties of the proposed ZNN model. For comparative purposes, the conventional gradient neural network is developed and exploited for solving online time-varying linear inequalities as well. Computer simulation results further verify and demonstrate the efficacy, novelty, and superiority of such a ZNN model and its method for solving time-varying linear inequalities.
The cost of annoying ads

Display advertisements vary in the extent to which they annoy users. While publishers know the payment they receive to run annoying ads, little is known about the cost such ads incur due to user abandonment. We conducted a two-experiment investigation to analyze ad features that relate to annoyingness and to put a monetary value on the cost of annoying ads. The first experiment asked users to rate and comment on a large number of ads taken from the Web. This allowed us to establish sets of annoying and innocuous ads for use in the second experiment, in which users were given the opportunity to categorize emails for a per-message wage and quit at any time. Participants were randomly assigned to one of three different pay rates and also randomly assigned to categorize the emails in the presence of no ads, annoying ads, or innocuous ads. Since each email categorization constituted an impression, this design, inspired by Toomim et al., allowed us to determine how much more one must pay a person to generate the same number of impressions in the presence of annoying ads compared to no ads or innocuous ads. We conclude by proposing a theoretical model which relates ad quality to publisher market share, illustrating how our empirical findings could affect the economics of Internet advertising.
Compressed network monitoring for ip and all-optical networks

We address the problem of efficient end-to-end network monitoring of path metrics in communication networks. Our goal is to minimize the number of measurements or monitors required to maintain an acceptable estimation accuracy. We present a framework based on diffusion wavelets and nonlinear estimation. Our procedure involves the development of a diffusion wavelet basis that is adapted to the monitoring problem. This basis exploits spatial and temporal correlations in the measured phenomena to provide a compressible representation of the path metrics. The framework employs nonlinear estimation techniques using l1 minimization to generate estimates for the unmeasured paths. We describe heuristic approaches for the selection of the paths that should be monitored, or equivalently, where hardware monitors should be located. We demonstrate how our estimation framework can improve the efficiency of end-to-end delay estimation in IP networks and reduce the number of hardware monitors required to track bit-error rates in all-optical networks (networks with no electrical regenerators).
Pulmonary hypertension in patients with chronic obstructive pulmonary disease: Recent advances in pathophysiology and management

Abstract: In patients with chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH) is associated with a worse prognosis. Recently, information has been increasing concerning the cellular and molecular aspects of the pathophysiology of PH in COPD. The most striking finding is the role of vascular endothelial cells and endogenous mediators released by these cells. Endothelial cell‐dependent relaxation is impaired in COPD patients with PH. Moreover, vascular remodelling in these patients is mainly responsible for irreversible PH in advanced COPD. Smoking cessation will slow down the progression of the disease process and may prevent the development of PH in COPD. The timing of initiation of long‐term oxygen therapy is important for the effective management of PH in COPD. Research on therapeutic agents for the effective treatment of PH is still needed in the management aspect of patients with COPD. This review focuses on the recent advances in our understanding of the pathophysiology and treatment of PH in COPD.
Effect of fiber treatment on the water absorption and mechanical properties of hemp fiber/polyethylene composites

The hemp fiber/polyethylene (PE) composites were prepared by varying the fiber shape (hemp flour and hemp fiber from thermomechanical refining), coupling agent (maleic anhydride grafted and copolymerized onto PE), coupling agent loading method (during fiber treating process in the thermomechanical refiner and compositing process in twin screw extruder), and compositing method (twin screw extruding and batch mixing). The paper firstly measured the moisture absorption properties of the treated fibers. The introduction of coupling agent during fiber treating process decreased effectively the moisture uptake. Then, the water absorption and mechanical properties were investigated on the hemp/PE composites. The loading of coupling agent during fiber treating process decreased the water uptake but also decreased the flexural yield strength, consequently resulted in lower flexural yield strength after water exposure. The composites prepared by batch mixing method were better than by twin screw extruding for the water resistance and mechanical properties. V C 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 127: 942-949, 2013
Hough transform with dynamic thresholding for robust and real-time detection of complex curves in images

A dynamic thresholding method is proposed for use in the Hough transform to detect complex curves in images robustly. While determining edge pixels contributing to the peak in the Hough space for detecting a curve with noise and other errors, the proposed method can endure the errors by detecting pixels coming from an equal-width shape which is centered at the curve with a small width everywhere along the curve. This equal-width shape detection capability is accomplished by the use of a dynamic threshold for pixel selection, which is derived from the use of the first-order directional derivative of the function describing the curve. Three conventional methods are compared to show the superiority in robustness of the proposed method via experimental results, and a real-time application of the method for quick detection of lines in omni-images is also demonstrated.
Biopharmaceutics: Topical Delivery of Keloid Therapeutic Drug, Tranilast, by Combined Use of Oleic Acid and Propylene Glycol as a Penetration Enhancer: Evaluation by Skin Microdialysis in Rats

Topical delivery of tranilast (N‐(3,4‐dimethoxycinnamoyl)anthranic acid), an inhibitor of collagen synthesis and a therapeutic drug for keloid and hypertrophic scar, was examined, in rats, with oleic acid alone or a combination of oleic acid and propylene glycol as penetration enhancer. Evaluation was by measurement of the concentration of tranilast in plasma and in the dialysate from skin microdialysis.
Reflection, Transmission and Diffraction Efficiencies in Homogenous Optical Thin Film and Grating Structures: An Overview

The matrix formalism is applied to describe various stratified and periodic systems that are used to couple optical energy into a dielectric film or medium. As the literature is often presenting cases for the transverse electric wave ( TE ), general analytical and numerical solutions are reviewed for many types of optical thin film systems with some emphasis on the transverse magnetic ( TM ) wave. This manuscript is divided into two main parts. In the first part, we look at stratified systems formed by a succession of multilayers and also present some applications for this type of optical systems such as bi-layer dielectric stacks. Tunneling across an air gap formed by two prisms’ long sides brought close to each other is also presented. Tunneling modes in optical system is reviewed in detail in systems that are probing an optical waveguide layer. In the second part of this manuscript, we are looking at optical systems in which a corrugated surface is used to couple energy into a medium. The matrix formalism used in this second part is applied mostly to grating waveguide structures and used in numerical computation of diffraction efficiencies ( DE ). Binary dielectric and metallic grating are also introduced with some emphasis on general ideas leading to the origin of photonic band-gap. This manuscript is reviewing various applications involving the matrix method supported by some results, but is also meant to be an overview with the main emphasis on optical thin film system grating waveguide structures.
HEVC video quality assessment database toward LTE system

Though a lot of video quality assessment (VQA) models have been researched, most of them are lack of a recognized video quality assessment database, especially for High Efficiency Video Coding (HEVC) encoded video transmit on Long Term Evolution (LTE) system. On the one hand, HEVC video coding technology is rapidly growing in popularity, thus, it needs to build a new VQA model for HEVC; on the other hand, the LTE system is more popular than other communicate systems currently, as well as, different channels of mobile communication system has different effects on video, therefore, it is necessary to damage video over LTE channel. To achieve that, this paper combines the Gilbert model with LTE system to damage HEVC video, and assesses the quality of deterioration video by the method of Single Stimulus Continuous Quality Evaluation(SSCQE). Finally, building HEVC video quality assessment database over LTE systems.
Users Polarization on Facebook and Youtube

Users online tend to select information that support and adhere their beliefs, and to form polarized groups sharing the same view—e.g. echo chambers. Algorithms for content promotion may favour this phenomenon, by accounting for users preferences and thus limiting the exposure to unsolicited contents. To shade light on this question, we perform a comparative study on how same contents (videos) are consumed on different online social media—i.e. Facebook and YouTube—over a sample of 12M of users. Our findings show that content drives the emergence of echo chambers on both platforms. Moreover, we show that the users’ commenting patterns are accurate predictors for the formation of echo-chambers.
Mechanical Analysis on the Scour of Submarine Pipeline

The reason about the scour of the submarine pipeline is researched in this paper. Through the mechanical analysis about the sand grain in the downstream of the pipe, the critical condition about of scour start is derived. The balance condition about the scour is studied. Through the mechanical analysis about the sand grain in the scour hole, the maximal scour hole depth is got.
Behavioral Contrast in Short Term Memory : Serial Binary Memory Models or Parallel Continuous Memory Models ?

This paper de"elops a model ,,"herein ST",'l primacy as ,veil as recenc~' effects can occur. The ST",I primacy effects can be used to generate correct immediate recall of short lists that have not been coded in LT:\1. The properties of the model are interpreted in terms of explicit nel:ral mechanisms. The STM primacy effect is a behavioral contrast effect that is analogous to the behavioral contrast that can occur during discrimination lear:-Jng. The adaptaticnal mechanism that &ccounts for these effects is al50 implicated in data on reaction time, retinal &daptation, ratio scales in choice beha,ior, and vor. P.estorfft)'Pe effects. Its ubiquitous appearance is due to the fact that it solves a univers2l problem concc~n;ng the parallel processing of patterned data b:. noisy cells ,vith finitely many excitable sites. It is argued that the STM primacy effect is not measured in interferenc~ experiments becausc it is masked b~. compe:itive ST",i interactions. Thesc competitive interactions do not prevent the L T~I p~. macy effect from influencing performance. The paper crit:cizes recent models of S1'l\I that use computer analogies to justify binal")' codes, serial ST~I buffers, and serial scanning procedures. Several deficiencies of serial models in dealing with psychological and neural proc~sing are overcome by a model in . vhich continuous STM activities and parallel real-time operations play an important role.
Study of Associated Genetic Variants in Indian Subjects Reveals the Basis of Ethnicity Related Differences in Susceptibility to Venous Thromboembolism

The genetic variants linked with the susceptibility of individuals to VTE are well known; however, the studies explaining the ethnicity based difference in susceptibility to VTE are limited. Present study assesses mutations in six candidate genes contributing to the etiology of VTE in Indian subjects. The study comprised 93 VTE patients and 102 healthy controls. A PCR-RFLP based analysis was performed for nine mutations in the following genes associated with VTE: favtor V Leiden (FVL), prothrombin, tissue factor pathway inhibitor (TFPI), fibrinogen-beta, plasminogen activator inhibitor 1 (PAI-1), and methylene tetrahydrofolatereductase (MTHFR). All the subjects were found to be monomorphic for FVL 1691G/A, prothrombin 20210G/A and TFPI −536C/T mutations. The mutation in the MTHFR gene (677C/T) was observed only in patients. Contrarily, higher frequency of mutation in the PAI-1 −844G/A and the fibrinogen-β −455G/A was observed in controls in comparison to the patients. This study suggests that the PAI-1 −844G/A and fibrinogen-β −455G/A could be protective variants against VTE in Indians. While MTHFR 677C/T mutation was found to be associated, in contrast to other populations, the established genetic variants FVL 1691G/A, prothrombin 20210G/A, and TFPI −536C/T may not be associated with VTE in Indians thus revealing the basis of ethnicity related differences in susceptibility of Indians to VTE.