Miracle-dz/UniFAR-FTUs huggingface dataset:
Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of a Vicia faba Hydrolysate, in a Healthy Male Population

Delayed onset muscle soreness (DOMS) due to intense physical exertion can negatively impact contractility and performance. Previously, NPN_1 (PeptiStrong™), a Vicia faba hydrolysate derived from a protein concentrate discovered through artificial intelligence (AI), was preclinically shown to help maintain muscle health, indicating the potential to mediate the effect of DOMS and alter molecular markers of muscle damage to improve recovery and performance. A randomised double-blind placebo-controlled trial was conducted on 30 healthy male (30–45 years old) volunteers (NCT05159375). Following initial strength testing on day 0, subjects were administered either placebo or NPN_1 (2.4 g/day). On day 14, DOMS was induced using resistance exercise. Strength recovery and fatigue were measured after 48 and 72 h. Biomarker analysis was performed on blood samples collected prior to DOMS induction and 0, 2, 48 and 72 h post-DOMS induction. NPN_1 supplementation significantly improved strength recovery compared to placebo over the 72 h period post-resistance exercise (p = 0.027), measured by peak torque per bodyweight, but not at individual timepoints. Muscle fatigue was significantly reduced over the same 72 h period (p = 0.041), as was myostatin expression (p = 0.006). A concomitant increase in other acute markers regulating muscle protein synthesis, regeneration and myoblast differentiation was also observed. NPN_1 significantly improves strength recovery and restoration, reduces fatigue and positively modulates alterations in markers related to muscle homeostasis.
The Road to Trustworthy 6G: A Survey on Trust Anchor Technologies

While 5G networks are driving a growing number of use cases in the fields of iot and industrial applications, the vision of the next generation of mobile communications systems already includes concepts massively transforming the way people will interact with the digital world through the network, as humans are shifting into the center of diverse network driven applications. Envisaged use cases and possibilities to provide services and resources in a distributed manner render an architectural solution for trust establishment a critical component of 6G networks. This survey provides an overview of terms and visions related to the topic of trust in general and in mobile communications systems. Requirements for an end-to-end trust building framework are derived, in order to give a starting point for the design process of a trust anchor service as a component of 6G networks.
ANALYSIS OF SPEED-DENSITY TRAFFIC FLOW MODELS ON A MERGE INFLUENCE SECTION IN UNINTERRUPTED FACILITY

An uninterrupted facility reflects the interrelation of cause and effect on the traffic volume speed density; therefore, if a ramp of traffic flow is merged into the main line at a merged section, single variables (such as speed or density) change, as well as interaction effects. Thus, this study used temporally- and spatially-continuous traffic data for various traffic conditions in order to find changes to correlations and interaction effects in a speed-density traffic flow model with a merging section. These changes were also analyzed in comparison with other sections. As a result of this analysis, it was found that the downstream section where traffic flows (decelerated by merging) can be depicted with "Greenshields" model and that the spatial transition occurs as traffic flow moves farther downstream. It was also found that the upstream, merge and downstream sections showed heterogeneous traffic flow characteristics, i.e., the free flow speed and the speed change rate versus flow density were different from each other.
Research on optimization of tourism route in West Sichuan based on ant colony algorithm

In recent years, tourism in Western Sichuan has just started, coupled with the impact of its own geographical characteristics, the travel research to adapt to the plateau area is still blank. When tourists travel, because there are many scenic spots, the scenic spots that they visit most in a limited time need to plan the path in advance. The current navigation software can only optimize the path between single points, It cannot realize how to choose an optimal path between multiple scenic spots. In view of the above problems, this paper combines the symbolic method of geospatial data provided by AreGIS software, realizes the path optimization problem between multiple scenic spots through ant colony algorithm, and forms a new western Sichuan tourism destination with air travel as the main line and multiple traffic linkage; Ease the inconvenience caused by long and rugged mountain roads in Western Sichuan tourism and improve travel efficiency.
Effects of Enamel Matrix Derivative on Cell Spheroids Made of Stem Cells Obtained from the Gingiva on Osteogenic Differentiation

Background and Objectives: A derivative of the enamel matrix was used to speed up periodontal regeneration, including the formation of new cementum, alveolar bone, and periodontal ligament. In this study, human gingiva-derived stem cell–derived cell spheroids were used to assess the effects of an enamel matrix derivative on cell viability, osteogenic differentiation, and mineralization. Materials and Methods: Human gingiva-derived stem cells were used to create spheroids, which were then coupled with unloaded control groups and an enamel matrix derivative at a final concentration of 2.7, 27, 270, and 2700 μg/mL. The morphological examination of the created stem cell spheroids took place on days 1, 3, 5, and 7. The Live/Dead Kit assay was used to determine the qualitative viability of cells on days 3 and 7. Using the Cell Counting Kit-8, the quantitative vitality of the cell spheroids was assessed on days 1, 3, and 5. On days 7 and 14, alkaline phosphatase activity assays and Alizarin Red S staining were carried out to examine the osteogenic differentiation of the cell spheroids. RUNX2 and COL1A1 expression levels on days 7 and 14 were determined using real-time polymerase chain reaction. Results: The added enamel matrix derivative at the tested concentrations did not significantly alter the morphology of the applied stem cells’ well-formed spheroids on day 1. On days 3 and 7, the majority of the spheroids’ cells fluoresced green while they were being cultivated. Alkaline phosphatase activity data revealed a substantial rise in the 2700 μg/mL group on day 7 when compared to the unloaded control (p < 0.05). On days 7 and 14, calcium deposits were distinctly seen in each group. In the 27 and 2700 μg/mL groups, the treatment with the enamel matrix derivative resulted in noticeably higher values for the Alizarin Red S staining (p < 0.05). qPCR results showed that adding an enamel matrix derivative to the culture of the 27 μg/mL group raised the level of RUNX2 mRNA expression. Conclusions: These results lead us to the conclusion that a derivative of the enamel matrix may be used to promote osteogenic differentiation in stem cell spheroids.
Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production

Amyloid-β peptides (Aβs) are produced via cleavage of the transmembrane region of the amyloid precursor protein (APP) by γ-secretase and are responsible for Alzheimer’s disease. Familial Alzheimer’s disease (FAD) is associated with APP mutations that disrupt the cleavage reaction and increase the production of neurotoxic Aβs, i.e., Aβ42 and Aβ43. Study of the mutations that activate and restore the cleavage of FAD mutants is necessary to understand the mechanism of Aβ production. In this study, using a yeast reconstruction system, we revealed that one of the APP FAD mutations, T714I, severely reduced the cleavage, and identified secondary APP mutations that restored the cleavage of APP T714I. Some mutants were able to modulate Aβ production by changing the proportions of Aβ species when introduced into mammalian cells. Secondary mutations include proline and aspartate residues; proline mutations are thought to act through helical structural destabilization, while aspartate mutations are thought to promote interactions in the substrate binding pocket. Our results elucidate the APP cleavage mechanism and could facilitate drug discovery.
An integrated approach to boundary finding in medical images

A key issue in biomedical image analysis is to accurately segment and quantify structures. Gradient based boundary finding and region based segmentation, the two conventional methods of image segmentation often suffer from a variety of limitations. Here the authors propose a method which endeavors to integrate the two approaches in an effort to form a unified approach that is robust to noise and poor initialization. The authors' approach uses Green's theorem to derive the boundary of a homogeneous region-classified area in the image and integrates this with a grey-level-gradient-based boundary finder. This combines the perceptual notions of edge/shape information with gray level homogeneity. A number of experiments were performed both on synthetic and real medical images of the brain and heart to evaluate the new approach and it is shown that the integrated method typically performs better than conventional gradient based boundary finding. <<ETX>>
Hydromagnetic oscillations of the Earth's core

The dispersion relationship for hydromagnetic waves in a rotating system indicates that, under plausible assumptions concerning the strength of the toroidal magnetic field in the earth's liquid core, the periods associated with slow planetary-scale waves in the core would be comparable with the characteristic time scales found in the geomagnetic secular variation, decades to centuries, and it now seems likely that such waves could also play a key role in the production of the geomagnetic field by the ‘dynamo’ process. Attempts to interpret specific features of the field in terms of hydromagnetic oscillations of the core (or of any other type of fluid motion, for that matter) have not yet proved entirely successful, for they encounter serious and in some cases fundamental mathematical difficulties. The present paper reviews theoretical work on free hydromagnetic oscillations of a bounded rotating fluid in the context of the geomagnetic problem.
Pronunciation Scoring With Goodness of Pronunciation and Dynamic Time Warping

The current pronunciation scoring based on Goodness of Pronunciation (GOP) uses posterior probabilities of the Acoustic Models. Such algorithms suffer from generalization since they are utilized to determine a score metric for each phoneme rather than on the completeness or comparison with the ideal utterance of the words. This paper proposes a novel method to overcome such limitations by using combined scores of prosodic, fluency, completeness, and accuracy. This is achieved using context-aware GOP in conjugation with dynamic time warping (DTW) matching of the pitch contours of a weighted average of the context tokens found in the audio file that is rich in mispronounced phonemes. The proposed work gives flexibility in tuning the results according to different speech aspects based on a single hyperparameter. The results achieved are encouraging and have been validated on the speechocean762 dataset, where Automatic Speech Recognition (ASR) model has been trained on the Librispeech dataset. The resultant mean error of the proposed approach is 3.38% and the value of the correlation coefficient achieved is 0.652.
The detection of interstellar OH absorption in the Zeta Ophiuchi cloud

New Copernicus scans have been made of several molecular line wavelengths in the ultraviolet spectrum of zeta Oph. Multiple scans in the far-ultraviolet and a new noise-reduction scheme for the near-ultraviolet were used to obtain significantly better signal-to-noise ratios than in previous observations. The OH D /sup 2/. sigma. /sup -/ - X /sup 2/II (0,0)Q1(/sup 3///sub 2/) transition at 1222.071 A was detected with an equivalent width of 3.5 +- 0.42 A, implying a column density of (1.54 - 1.96) x 10/sup 14/ cm/sup -2/. Improved upper limits were determined for the remainder of the molecules which were sought. Although the abundance of OH exceeds the values predicted by published calculations using gas-phase ion-molecule reactions, the discrepancy is not large, and probably does not necessitate the assumption of other formation processes. (auth)
Is the Gravitational Constant Changing

The question posed by the title is not yet conclusively resolved. Nonetheless, determinations of the lunar tidal acceleration based on dynamical time scales are now in reasonable accord with one another, whether based on the transits of Mercury, ancient eclipse observations, ocean tide models, or artificial satellite observations; these give a purely tidal component of −28.8 ± 1.5 ″/cy2. Lunar occultations and laser ranging now give concordant results for the total anomalous acceleration of about −22.8 ± 1.5. The difference in these results gives an acceleration of possible cosmological origin of \( \dot n/n = + 3.5 \pm 1.2 \times 10^{ - 11} \) per year, which is also consistent with very preliminary planetary radar studies. If interpreted in the scalar covariant cosmology of Canuto and Hsieh, this implies that Ġ/G = (−6.9 ± 2.4) × 10−11 per year, if measured in atomic time, but zero if measured in dynamical time. The implications for relativity and cosmology are discussed briefly in the paper, scheduled for the Astrophysical Journal issue of 1 September 1981.
The extreme, possible symbiotic Mira V 407 Cyg and its relevance to the OH/IR sources

Les nouvelles magnitudes optiques et IR sont presentees et toutes les donnees photometriques disponibles sont passees en revue pour la variable V407 Cyg. La nature de V407 Cyg est discutee et une classification comme etoile symbiotique est suggeree. La presence d'une variable Mira dans V407 Cyg avec une periode de pulsation de 745 j semble bien etablie. Les variables Mira avec une periode de pulsation aussi longue sont generalement des sources OH/IR, avec une enveloppe de poussiere tres epaisse qui empeche l'observation directe de l'etoile centrale. L'enveloppe de poussiere mince autour de la variable Mira dans V407 Cyg pourrait etre due a la presence d'une naine blanche en phase d'accretion dont le rayonnement ionisant empeche la formation de poussiere dans une grande fraction du vent de la variable Mira.
Entrepreneurial Intention and Skills Needed by Today's Youths for Sustainable Development

The development of entrepreneurial intention and raising the attitudes of today's youths to launch their own firms in Nigeria has continued to center on entrepreneurship and skill acquisition. Based on these, the study looked into various skills needed by today's youths for Sustainable Development. The study was further guided by two research questions and one hypothesis tested at the 0.05 level of significance. A descriptive survey research approach was implemented. The participants in this study were students and lecturers at Nwafor Orizu College of Education, Nsugbe, Anambra State, Nigeria. The population size was made up of 70 students and 30 lecturers. Data were collected using a questionnaire produced by the researcher. The responses were analysed using arithmetic mean and standard deviation scores, and the null hypothesis was tested using a t-test. The result revealed that self-motivation is among the influencing factors of entrepreneurial intentions by today's youths. Additionally, creativity was considered essential since most entrepreneurs are beginning from zero position with limited resources. The results further revealed that students and lecturers do not differ significantly in their mean perception scores regarding sustainable entrepreneurial soft skills required by today's youths. It was recommended among others that the federal government should create an atmosphere that is conducive to learning and supply all the tools and resources required for Nigeria's economy to grow sustainably.
Lifetime Analysis of Mica Paper Capacitors Under Microsecond Pulse

In recent years, the development of mica paper capacitor (MPC) technology has dramatically improved the withstand voltage and energy storage density of capacitors, which is suitable for pulse power systems. The lifetime of capacitors is a key factor that ensures the reliability of a system. In this article, the investigation of the lifetime characteristics of MPCs under microsecond pulse is presented. The structure of an MPC is analysed, and two numerical simulations are performed to study its characteristics. A lifetime test platform is established to test MPCs, which has stable operation performance. Essential electrical degradation parameters of MPCs are obtained and analyzed. The operational factors that influence the lifetime of MPCs are analysed, and a lifetime empirical model under given operational factors is proposed based on the lifetime test results. The results suggest that the lifetime empirical model could match well with lifetime test results. Furthermore, the structure of a pulse forming network (PFN)-Marx is analyzed by the lifetime model, and constructive suggestions are proposed. This article is devoted to studying the characteristics of MPCs and analyzing the lifetime under various operational factors, which finally helps the device to specify operating conditions and ensure reliability.
A Comparative Study of High School Students' Math Achievement and Attitudes: Do Math Teacher Qualifications Matter?

Using nationally representative High School Longitudinal Study of 2009 data, this quantitative study examined how math teacher qualifications affect U. S. 9th graders’ math achievement and attitudes. The study is guided by the Cognitive Apprenticeship Theory that emphasizes that expert teachers enable students to learn as apprentices and construct knowledge within the activity, context, and culture in which it is learned. The study shows that not only does cognitive apprenticeship enable skill development and knowledge acquisition, but it shapes student math self-efficacy and interest in the subject, and it develops their math identity if students viewed math teachers as role models. The study employs a comparative research design to explore the main effects and interaction between teachers’ credential type and field of study degree on student outcomes. One notable finding is that teacher credentials (i.e., level of education certification) affected student math achievement and math identity but had weaker effects on math self-efficacy, math utility and interest in math courses. Second, holding a math degree affected students’ math achievement and math identity, while holding a degree in education had some positive effects on increasing students’ interest in math courses. Results have direct implications for the field of Mathematics Education showing that teacher qualifications affect student beliefs and attitudes toward mathematics.
Evaluation of Precipitation Estimates from Remote Sensing and Artificial Neural Network Based Products (PERSIANN) Family in an Arid Region

Accurate and continuous rainfall monitoring is essential for effective water resources management, especially in arid and semi-arid regions such as the United Arab Emirates (UAE). Significant spatio-temporal precipitation variation in the UAE necessitates the use of the latest techniques to measure rainfall intensity accurately. This study investigates the consistency and applicability of four satellite precipitation products, namely PERSIANN, PERSIANN-CCS, PERSIANN-CDR, and PDIR-Now, over the UAE. Daily time series data from 2011 to 2020 were analyzed using various statistical measures and climate indices to develop the belief in the products and for their inter-comparison. The analysis revealed that the average probability of detection (POD) for PDIR and CDR was the highest, with values ranging from 0.7–0.9 and 0.6–0.9, respectively. Similarly, CDR has a better Heidke Skill Score (HSS) with an average value of 0.26. CDR outperformed its counterparts with an average correlation coefficient value of 0.70 versus 0.65, 0.40, and 0.34 for PDIR, CCS, and PERSIANN, respectively. Precipitation indices analysis revealed that all the products overestimated the number of consecutive wet days by 15–20%, while underestimating consecutive dry days by 5–10%. The quantitative estimations indicate that all the products were matching with the gauge values during the wet months (January–April), while they showed significant overestimation during the dry months. CDR and PDIR were in close agreement with the gauge data in terms of maximum daily rainfall with an error of less than 10% for both products. As compared to others, PERSIANN-CDR provided better estimates, particularly in terms of capturing extreme rainfall events and spatial distribution of rainfall. This study provides the first comprehensive evaluation of four PERSIANN family products based on recent daily rainfall data of UAE. The findings can provide future insights into the applicability and improvement of PERSIANN products in arid and semi-arid regions.
A Log File Analysis on the Validity of Partial Solutions in Figural Matrices Tests

As a component of many intelligence test batteries, figural matrices tests are an effective way to assess reasoning, which is considered a core ability of intelligence. Traditionally, the sum of correct items is used as a performance indicator (total solution procedure). However, recent advances in the development of computer-based figural matrices tests allow additional indicators to be considered for scoring. In two studies, we focused on the added value of a partial solution procedure employing log file analyses from a computer-based figural matrices test. In the first study (n = 198), we explored the internal validity of this procedure by applying both an exploratory bottom-up approach (using sequence analyses) and a complementary top-down approach (using rule jumps, an indicator taken from relevant studies). Both approaches confirmed that higher scores in the partial solution procedure were associated with higher structuredness in participants’ response behavior. In the second study (n = 169), we examined the external validity by correlating the partial solution procedure in addition to the total solution procedure with a Grade Point Average (GPA) criterion. The partial solution procedure showed an advantage over the total solution procedure in predicting GPA, especially at lower ability levels. The implications of the results and their applicability to other tests are discussed.
The Gravity-induced Quasi-Gaussian Correlation Hierarchy

The correlation hierarchy that first emerges from a Gaussian field, with a given initial spectrum, owing to the nonlinearities of the dynamics in an expanding universe, is calculated. The mean matter p-point correlation functions are shown to be given by a set of characteristic numbers S p , so that c = S p p-1 at the lowest order in , where c stands for the connected part of the expectation values. These parameters, calculated assuming no cosmological constant, enlarge at every order the results obtained by Peebles and Fry for S 3 and S 4 . They turn out to be completely independent of the initial spectrum, and almost independent of Ω