Miracle-dz/UniFAR-FTUs huggingface dataset:
Turtle Dorsal Cortex Pyramidal Neurons Comprise Two Distinct Cell Types with Indistinguishable Visual Responses

A detailed inventory of the constituent pieces in cerebral cortex is considered essential to understand the principles underlying cortical signal processing. Specifically, the search for pyramidal neuron subtypes is partly motivated by the hypothesis that a subtype-specific division of labor could create a rich substrate for computation. On the other hand, the extreme integration of individual neurons into the collective cortical circuit promotes the hypothesis that cellular individuality represents a smaller computational role within the context of the larger network. These competing hypotheses raise the important question to what extent the computational function of a neuron is determined by its individual type or by its circuit connections. We created electrophysiological profiles from pyramidal neurons within the sole cellular layer of turtle visual cortex by measuring responses to current injection using whole-cell recordings. A blind clustering algorithm applied to these data revealed the presence of two principle types of pyramidal neurons. Brief diffuse light flashes triggered membrane potential fluctuations in those same cortical neurons. The apparently network driven variability of the visual responses concealed the existence of subtypes. In conclusion, our results support the notion that the importance of diverse intrinsic physiological properties is minimized when neurons are embedded in a synaptic recurrent network.
Essentialist Beliefs About Homosexuality: Structure and Implications for Prejudice

The structure of beliefs about the nature of homosexuality, and their association with antigay attitudes, were examined in three studies (Ns = 309, 487, and 216). Contrary to previous research, three dimensions were obtained: the belief that homosexuality is biologically based, immutable, and fixed early in life; the belief that it is cross-culturally and historically universal; and the belief that it constitutes a discrete, entitative type with defining features. Study 1 supported a three-factor structure for essentialist beliefs about male homosexuality. Study 2 replicated this structure with confirmatory factor analysis, extended it to beliefs about lesbianism, showed that all three dimensions predicted antigay attitudes, and demonstrated that essentialist beliefs mediate associations between prejudice and gender, ethnicity, and religiosity. Study 3 replicated the belief structure and mediation effects in a community sample and showed that essentialist beliefs predict antigay prejudice independently of right-wing authoritarianism, social dominance orientation, and political conservatism.
An RKHS formulation of the inverse regression dimension-reduction problem

Suppose that $Y$ is a scalar and $X$ is a second-order stochastic process, where $Y$ and $X$ are conditionally independent given the random variables $\xi_1,. ,\xi_p$ which belong to the closed span $L_X^2$ of $X$. This paper investigates a unified framework for the inverse regression dimension-reduction problem. It is found that the identification of $L_X^2$ with the reproducing kernel Hilbert space of $X$ provides a platform for a seamless extension from the finite- to infinite-dimensional settings. It also facilitates convenient computational algorithms that can be applied to a variety of models.
A validated security policy modeling approach

The paper presents a security policy modeling approach that can be applied to many types of systems, including networks and distributed systems. The approach is driven by security requirements and by system architecture. It is compatible with the modeling principles offered by recent modeling guidelines and the TCSEC modeling requirements at the B1-A1 assurance levels. The approach has been validated through its application to various development, certification and research projects, including tactical systems, secure gateways, and C/sup 3/I systems. The approach presented here has been favorably reviewed by security evaluation teams for government agencies. The paper illustrates the approach by applying it to an example tactical system. <<ETX>>
Assessing the User Experience Design as a Persuasive Methodology in a Real World Sport Application

In the last years, researchers are experimenting with innovative methodologies to help people in their daily training routines. Our research activity focuses on the study of the effects of the former technologies on people's sport habits. This work describes an experimentation conducted on Everywhere Run! (EWRun), a mobile application part of a bigger platform, that aims at helping people to stay active behaving like a virtual personal trainer. In this work we show some interesting results that arise from recent radical changes we made to the software usability and its graphical design. We observed a considerable increment of the user base and, as a consequence, of the total number of daily trainings. To statistically prove the effectiveness of the redesign, we decided to compare the two versions of the application. The results confirm its effectiveness in terms of usability and brought us to investigate how the new design is affecting user motivation by means of a custom questionnaire and a well known motivation assessment tool. The positive result observed will be the starting point of our forthcoming researches: we aim at further validating the results presented in this work over a longer period of time and over a larger number of real users.
Pharmacist-led management of chronic pain in primary care: costs and benefits in a pilot randomised controlled trial

Objectives To explore differences in mean costs (from a UK National Health Service perspective) and effects of pharmacist-led management of chronic pain in primary care evaluated in a pilot randomised controlled trial (RCT), and to estimate optimal sample size for a definitive RCT. Design Regression analysis of costs and effects, using intention-to-treat and expected value of sample information analysis (EVSI). Setting Six general practices: Grampian (3); East Anglia (3). Participants 125 patients with complete resource use and short form-six-dimension questionnaire (SF-6D) data at baseline, 3 months and 6 months. Interventions Patients were randomised to either pharmacist medication review with face-to-face pharmacist prescribing or pharmacist medication review with feedback to general practitioner or treatment as usual (TAU). Main outcome measures Differences in mean total costs and effects measured as quality-adjusted life years (QALYs) at 6 months and EVSI for sample size calculation. Results Unadjusted total mean costs per patient were £452 for prescribing (SD: £466), £570 for review (SD: £527) and £668 for TAU (SD: £1333). After controlling for baseline costs, the adjusted mean cost differences per patient relative to TAU were £77 for prescribing (95% CI −82 to 237) and £54 for review (95% CI −103 to 212). Unadjusted mean QALYs were 0.3213 for prescribing (SD: 0.0659), 0.3161 for review (SD: 0.0684) and 0.3079 for TAU (SD: 0.0606). Relative to TAU, the adjusted mean differences were 0.0069 for prescribing (95% CI −0.0091 to 0.0229) and 0.0097 for review (95% CI −0.0054 to 0.0248). The EVSI suggested the optimal future trial size was between 460 and 690, and between 540 and 780 patients per arm using a threshold of £30 000 and £20 000 per QALY gained, respectively. Conclusions Compared with TAU, pharmacist-led interventions for chronic pain appear more costly and provide similar QALYs. However, these estimates are imprecise due to the small size of the pilot trial. The EVSI indicates that a larger trial is necessary to obtain more precise estimates of differences in mean effects and costs between treatment groups. Trial registration number ISRCTN06131530.
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism among individual humans (Kleinbloesem, C. H., van Brummelen, P., Faber, H., Danhof, M., Vermeulen, N. P. E., and Breimer, D.D. (1984) Biochem. Pharmacol. 33, 3721-3724). Nifedipine oxidation has been shown to be catalyzed by cytochrome P-450 (P-450) enzymes. Reconstitution, immunoinhibition, and induction studies with rat liver indicated that the forms designated P-450UT-A and P-450PCN-E are the major contributors to microsomal nifedipine oxidation. The P-450 which oxidizes nifedipine (P-450NF) was purified to electrophoretic homogeneity from several human liver samples. Antibodies raised to P-450NF were highly specific as judged by immunoblotting analysis and inhibited greater than 90% of the nifedipine oxidase activity in human liver microsomes. A monoclonal antibody raised to the human P-450 preparation reacted with both human P-450NF and rat P-450PCN-E. Immunoblotting analysis of 39 human liver microsomal samples using anti-P-450NF antibodies revealed the same 52,000-dalton polypeptide, corresponding to P-450NF, with only one of the microsomal samples showing an additional immunoreactive protein. The level of nifedipine oxidase activity was highly correlated with the amount of P-450NF thus detected using either polyclonal (r = 0.78) or monoclonal (r = 0.65) antibodies, suggesting that the amount of the P-450NF polypeptide may be a major factor in influencing the level of catalytic activity in humans as well as rats. Cytochrome b5 enhanced the catalytic activity of reconstituted P-450NF, and anti-cytochrome b5 inhibited nifedipine oxidase activity in human liver microsomes. P-450NF also appears to be a major contributor to human liver microsomal aldrin epoxidation, d-benzphetamine N-demethylation, 17 beta-estradiol 2- and 4-hydroxylation, and testosterone 6 beta-hydroxylation, the major pathway for oxidation of this androgen in human liver microsomes.
Rhabdoid papillary meningioma: A clinicopathologic case series study

World Health Organization (WHO) grade III meningiomas are subclassified on the basis of their architectural pattern into papillary and rhabdoid subtypes. Some meningiomas even combine papillary architecture with rhabdoid cytology. Additionally, they always show malignant histological features, follow an aggressive clinical course and tend to spread through the CSF after frequent local recurrence. We render the first series of rhabdoid papillary meningioma with review of the literature to further elucidate its biological behavior. From six patients (three male, three female), nine specimens of rhabdoid papillary meningioma were obtained between 1994 and 2010. Correlations of histologic parameters, immunohistochemical study, and clinical features were assessed. The mean age of patients was 44.7 years at their first operation. The mean postoperative follow‐up period was 63.2 months. Five patients experienced tumor recurrence, and one of them died from the disease after diffuse leptomeningeal dissemination. The mean time to first recurrence was 28 months. Only one patient was free of tumoral recurrence after an 8‐year follow‐up. Immunohistochemically, all tumors were positive for vimentin and epithelial membrane antigen. MIB‐1 labeling indices were higher following tumor recurrence. The present study expands the clinicopathologic horizon of rhabdoid papillary meningioma and suggests that it will behave aggressively based on its histology and concomitant features of atypia or malignancy or high MIB‐1 labeling indices. Close follow‐up and aggressive treatments of these tumors are warranted.
Dual‐polarized MIMO antenna system for WiFi and LTE wireless access point applications

In this paper, a dual‐polarized multiple‐input multiple‐output (MIMO) antenna system suitable for indoor wireless access point is proposed. The presented MIMO antenna system consists of two coplanar‐waveguide‐fed monopole antennas with orthogonally polarized modes. According to the closely spaced structure of the MIMO antenna system, the mutual coupling between the ports is a big challenge. Therefore, a new structure of parasitic element is introduced in order to improve the mutual coupling between the ports. For the purpose of validating the simulated results, the antenna prototype has been fabricated and measured; the comparison of the results shows that there is an acceptable agreement between the measurement and simulation results. The proposed design covers the frequency bands of WiFi (2.4 GHz), Worldwide Interoperability for Microwave Access (2.3 and 2.5 GHz), and Long‐Term Evolution (LTE; 1.5 and 2.6 GHz) applications with a reflection coefficient less than −10 dB and a mutual coupling coefficient better than −15 dB. The MIMO antenna system provides an envelope correlation coefficient less than 0.15, polarization diversity gain more than 9.985 dB, and quasi‐omnidirectional pattern within the expected frequency band. In addition, LTE downlink throughput measurements show that the proposed antenna system delivers data rates close to the theoretical maximum for quadrature phase shift keying, 16 quadrature amplitude modulation (QAM), and 64‐QAM modulations. Copyright © 2014 John Wiley & Sons, Ltd.
Combination of age and head pose for adult face verification

Age progression and other sources of variations such as head pose change have adverse effects on the performance of face verification systems. In this paper, we propose to manage the influence of both the age progression and head pose change on the adult face verification system by a general Q-stack age modeling technique, which uses the age and head pose as class-independent quality measures together with the scores from baseline classifiers, in order to obtain better verification performance. This allows for improved long-term class separation by introducing a 2D parameterized decision boundary in the scores-age space using a short-term enrollment model. This new method, based on the concept of classifier stacking with age- and head pose aware decision boundary compares favorably with the conventional face verification approach, which uses age- and head-pose-independent decision threshold calculated only in the score space at the time of enrollment. In this paper, we also show the advantages of user-specific approach for the face verification task over user-independent approach. The proposed approach is evaluated on the MORPH database.
Cavities determine the pressure unfolding of proteins

It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by pressure implies that the molar volume of the unfolded state of a protein is smaller than that of the folded state. This decrease in volume has been proposed to arise from differences between the density of bulk water and water associated with the protein, from pressure-dependent changes in the structure of bulk water, from the loss of internal cavities in the folded states of proteins, or from some combination of these three factors. Here, using 10 cavity-containing variants of staphylococcal nuclease, we demonstrate that pressure unfolds proteins primarily as a result of cavities that are present in the folded state and absent in the unfolded one. High-pressure NMR spectroscopy and simulations constrained by the NMR data were used to describe structural and energetic details of the folding landscape of staphylococcal nuclease that are usually inaccessible with existing experimental approaches using harsher denaturants. Besides solving a 100-year-old conundrum concerning the detailed structural origins of pressure unfolding of proteins, these studies illustrate the promise of pressure perturbation as a unique tool for examining the roles of packing, conformational fluctuations, and water penetration as determinants of solution properties of proteins, and for detecting folding intermediates and other structural details of protein-folding landscapes that are invisible to standard experimental approaches.
Hypercholesterolemia Tunes Hematopoietic Stem/Progenitor Cells for Inflammation and Atherosclerosis

As the pathological basis of cardiovascular disease (CVD), atherosclerosis is featured as a chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD. Accumulated studies have shown that hypercholesterolemia is associated with myeloid cell expansion, which stimulates innate and adaptive immune responses, strengthens inflammation, and accelerates atherosclerosis progression. Hematopoietic stem/progenitor cells (HSPC) in bone marrow (BM) expresses a panel of lipoprotein receptors to control cholesterol homeostasis. Deficiency of these receptors abrogates cellular cholesterol efflux, resulting in HSPC proliferation and differentiation in hypercholesterolemic mice. Reduction of the cholesterol level in the lipid rafts by infusion of reconstituted high-density lipoprotein (HDL) or its major apolipoprotein, apoA-I, reverses hypercholesterolemia-induced HSPC expansion. Apart from impaired cholesterol metabolism, inhibition of reactive oxygen species production suppresses HSPC activation and leukocytosis. These data indicate that the mechanisms underlying the effects of hypercholesterolemia on HSPC proliferation and differentiation could be multifaceted. Furthermore, dyslipidemia also regulates HSPC-neighboring cells, resulting in HSPC mobilization. In the article, we review how hypercholesterolemia evokes HSPC activation and mobilization directly or via its modification of BM microenvironment. We hope this review will bring light to finding key molecules to control HSPC expansion, inflammation, and atherosclerosis for the treatment of CVD.
A Distribution based Approach of Outlier Removal for Software Effort Data

are unavoidably a few outliers in the software measurement data. When software effort estimation models are made using the data samples with outliers, these models reduce the effort estimation precision for future planning. Therefore, this work investigated the influence of outlier upon the accuracy of prediction and proposed a distribution based outlier elimination method for effort estimation. The proposed work shows that the applied outlier elimination method improves the estimation accuracy of the software effort estimation process. In contrast, the effects of outlier elimination on the accuracy of effort estimation may differ depending on the characteristics of the data set, the effort estimation method.
Molecular Genetic Variation in Emmonsia crescens andEmmonsia parva, Etiologic Agents of Adiaspiromycosis, and Their Phylogenetic Relationship to Blastomyces dermatitidis (Ajellomyces dermatitidis) and Other Systemic Fungal Pathogens

ABSTRACT Emmonsia crescens, an agent of adiaspiromycosis,Blastomyces dermatitidis, the agent of blastomycosis, andHistoplasma capsulatum, the agent of histoplasmosis, are known to form meiotic (sexual) stages in the ascomycete genusAjellomyces (Onygenaceae,Onygenales), but no sexual stage is known for E. parva, the type species of the genus Emmonsia. To evaluate relationships among members of the putativeAjellomyces clade, large-subunit ribosomal and internal transcribed spacer region DNA sequences were determined from PCR-amplified DNA fragments. Sequences were analyzed phylogenetically to evaluate the genetic variation within the genus Emmonsiaand evolutionary relationships to other taxa. E. crescens and E. parva are distinct species.E. crescens isolates are placed into two groups that correlate with their continents of origin. Considerable variation occurred among isolates previously classified as E. parva. Most isolates are placed into two closely related groups, but the remaining isolates, including some from human sources, are phylogenetically distinct and represent undescribed species. Strains ofB. dermatitidis are a sister species of E. parva. Paracoccidioides brasiliensis andHistoplasma capsulatum are ancestral to mostEmmonsia isolates, and P. brasiliensis, which has no known teleomorph, falls within the Ajellomycesclade.
Testosterone therapy and prostate cancer

The use of exogenous testosterone to treat hypogonadism in the men with a history of prostate cancer (CaP) remains controversial due to fears of cancer recurrence or progression. Due to the detrimental impact of hypogonadism on patient quality of life, recent work has examined the safety of testosterone therapy (TTh) in men with a history of CaP. In this review, we evaluate the literature with regards to the safety of TTh in men with a history of CaP. TTh results in improvements in quality of life with little evidence of biochemical recurrence or progression in men with a history of CaP, or de novo cancer in unaffected men. An insufficient amount of evidence is currently available to truly demonstrate the safe use of TTh in men with low risk CaP. In men with high-risk cancer, more limited data suggest that TTh may be safe, but these findings remain inconclusive. Despite the historic avoidance of TTh in men with a history of CaP, the existing body of evidence largely supports the safe and effective use of testosterone in these men, although additional study is needed before unequivocal safety can be demonstrated.
A Novel Framework for a Systematic Integration of Pneumatic-Muscle-Actuator-Driven Joints into Robotic Systems Via a Torque Control Interface

In this paper, two different torque control approaches for PMA-driven (PMA = Pneumatic muscle actuator) revolute joints are presented and tested. In previous work controllers for PMA-driven robots are typically customized for the use on a specific robotic system. In contrast, the proposed controllers define a general control interface for every robot that is actuated by PMA-driven joints. It will be shown that controlling the torque of a PMA-driven joint enables the use of standard robotic motion control frameworks, because the torque represents the natural input of the robotic equation of motion. Therefore, both proposed torque control approaches are interconnecting PMAs and their challenging characteristics on the one hand and “conventional” motion control strategies for robots on the other hand. After a detailed discussion of two different torque control approaches, we show that a torque controller handles all characteristics and dynamics of a PMA-driven joint internally, which implies that only its bandwidth and its static torque characteristic must be taken into account for the design of the outer motion control loop. This feature simplifies the integration of PMA-driven joints in robotic systems enormously, as will be demonstrated by a design of a cascade-structured, flatness-based motion controller for an exemplary robot with one degree of freedom.