Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic evaluation of sQ-standardized grass allergy immunotherapy tablet (grazax ® ) in children

Background: Grass pollen-induced rhinoconjunctivitis is a common allergic respiratory disorder affecting over 20% of the UK population in terms of quality of life and sleep, work, and school patterns. The SQ-standardized grass allergy immunotherapy tablet (AIT) has been demonstrated as a disease-modifying treatment which gives a sustained effect even after completion of a treatment course. The objective of this study was to provide an economic assessment of whether treatment with the SQ-standardized grass AIT, Grazax ® ( Phleum pratense ) in combination with symptomatic medications is preferable to the standard of care using symptomatic medications only. The analysis was performed for children with grass pollen-induced rhinoconjunctivitis, with or without concomitant asthma, in the UK. Methods: The model evaluated the two treatment regimens in a cohort of 1,000 children from a payer’s perspective. Treatment was modeled in terms of management of symptoms, impact on resource use, and development of allergic asthma. The analysis modeled the use of SQ-standardized grass AIT and the sustained effects of treatment over a 9-year time horizon (ie, 3 years of treatment, with modeled long-term benefits). Data inputs were drawn from a recent clinical trial, published studies, and databases. Results: SQ-standardized grass AIT improves patient outcomes, generating an incremental cost per quality-adjusted life year gained of £12,168. This is below commonly accepted thresholds in the UK. Conclusion: The resulting incremental cost per QALY falls below commonly accepted willingness to pay thresholds. Therefore, the SQ-standardized grass AIT is a cost-effective option for the treatment of grass pollen-induced rhinoconjunctivitis in the UK pediatric population.
Aliso: A Journal of Systematic and Floristic Botany Aliso: A Journal of Systematic and Floristic Botany

Costaceae are a pantropical family, distinguished from other families within the order Zingiberales by their spiral phyllotaxy and showy labellum comprised of five fused staminodes. While the majority of Costaceae species are found in the neotropics, the pantropical distribution of the family as a whole could be due to a number of historical biogeographic scenarios, including continental-drift mediated vicariance and long-distance dispersal events. Here, the hypothesis of an ancient Gondwanan distri bution followed by vicariance via continental drift as the leading cause of the current pantropical distribution of Costaceae is tested, using molecular dating of cladogenic events combined with phy logeny-based biogeographic analyses. Dispersal-Vicariance Analysis (DIVA) is used to determine an cestral distributions based upon the modem distribution of extant taxa in a phylogenetic context. Diversification ages within Costaceae are estimated using chloroplast DNA data (trnL-F and trnK) analyzed with a local clock procedure. In the absence of fossil evidence, the divergence time between Costaceae and Zingiberaceae, as estimated in an ordinal analysis of Zingiberales, is used as the cali bration point for converting relative to absolute ages. The results of the temporal analysis based on extant taxa indicate that the initial diversification within Costaceae occurred approximately 65 million years ago, long after the final break up of the Gondwanan supercontinent. Considering this minimum age of diversification, potential scenarios for the current biogeographic patterns found in Costaceae are presented in a temporal and spatial context. The evolution of specialized floral forms associated with specific pollinators is also discussed within the biogeographic framework.
Using the PMO to enforce and standardize the attention of Using the PMO to enforce and standardize the attention of software project managers to needs of software project teams software project managers to needs of software project teams

: Software project teams (SPTs) are critical stakeholders. Their contribution in successful delivery of software projects is unquestionable. However, the empirical evidence of their importance seems to exist on paper only, as software project managers (SPMs) and scholars in the project management field ignore their individual needs, and as a result, SPTs remain the most neglected stakeholder group in the software industry. In endeavoring to address the neglect of SPTs by SPMs, the authors of this study developed a model aimed at assisting SPMs to pay due consideration to the needs of this important stakeholder group. At the heart of the model’s functionality is the Project Management Office (PMO), which intends to enforce and standardize the gathering and addressing of software project team needs and interests by SPMs. The aim of the research study is to investigate how the functions of the PMO can be applied to operationalize the enforcement and standardization of the overall function of the model. Since the study is practical-oriented, the pragmatic interpretive approach was considered a suitable methodology. Through the interpretative methodology, several appropriate functions of the PMO, such as «Project management methodology, standards, and tooling», «Monitoring and controlling project performance», «Human resource management» and «Development of project management competencies» as established from project management literature were utilized to achieve the study’s purpose. Even though the interpretation process was guided by literature, the inference was also influenced, to a certain extent, by the researcher opinion as «interested observer». Therefore, the approach presents a limitation to the study. Future studies should include the validation of the feasibility of the study’s claim in a real-world project setup
Geochronology and geochemistry of the Taipingchuan copper-molybdenum deposit in Inner Mongolia,and its geological significances

Recently discovered Taipingchuan porphyry Cu-Mo deposit is located in the north of Derbugan metallogenic belt,Ergun city of Inner Mongolia.Concentric rings of hydrothermal alteration and Cu-Mo mineralization occurred surrounding the granodiorite porphyry.Two hydrothermal alteration zones from the host porphyry to wall rocks have been recognized in Taipingchuan mine:A silicified-sericite zone and an argillic alteration zone.The Cu-Mo mineralization is clearly controlled by the silicified-sericite alteration.By using the zircon U-Pb dating methods a precise age data of the host porphyry is obtained.The dating data show that the age of host porphyry is 202 ± 5.7Ma. The inherited zircon(784Ma) has also been found in the host porphyry,which indicates that a Proterozoic block was probably located in the study area.Geochemically,the host porphyry of Wunugetushan possesses some geochemical characteristics of adakite(i.e.,high SiO2,Al2O3,Na2O and Sr contents,as well as La/Yb ratios,low MgO,Y and HREE contents). Some geochemical characteristics of the host porphyry,including relatively high SiO2,Yb contents and Th/Nb,Ce/Nb ratios and relatively low Al2O3,TiO2,MgO,Sr,Th contents and Th/Ce ratio indicate that the porphyry derived from partial melting of the subducted slab.The Sr-Nd isotopic composition of the porphyry displays an initial(87 Sr/86 Sr) i ratio of 0.70943 to 0.71019,a negative eNd(t) values of -3.4 to -3.9. The Sr-Nd isotopic data indicates that Proterozoic block had some contribution to the magma sources of the host porphyry.Combining the regional geology,we infer that the subduction of Mongol-Okhotsk ocean slab under the Ergun block led to the host porphyry forming,and Taipingchuan Cu-Mo deposit was related to a continental arc environment.
In-Advance Prediction of Pressure Ulcers via Deep-Learning-Based Robust Missing Value Imputation on Real-Time Intensive Care Variables

Pressure ulcers (PUs) are a prevalent skin disease affecting patients with impaired mobility and in high-risk groups. These ulcers increase patients’ suffering, medical expenses, and burden on medical staff. This study introduces a clinical decision support system and verifies it for predicting real-time PU occurrences within the intensive care unit (ICU) by using MIMIC-IV and in-house ICU data. We develop various machine learning (ML) and deep learning (DL) models for predicting PU occurrences in real time using the MIMIC-IV and validate using the MIMIC-IV and Kangwon National University Hospital (KNUH) dataset. To address the challenge of missing values in time series, we propose a novel recurrent neural network model, GRU-D++. This model outperformed other experimental models by achieving the area under the receiver operating characteristic curve (AUROC) of 0.945 for the on-time prediction and AUROC of 0.912 for 48h in-advance prediction. Furthermore, in the external validation with the KNUH dataset, the fine-tuned GRU-D++ model demonstrated superior performances, achieving an AUROC of 0.898 for on-time prediction and an AUROC of 0.897 for 48h in-advance prediction. The proposed GRU-D++, designed to consider temporal information and missing values, stands out for its predictive accuracy. Our findings suggest that this model can significantly alleviate the workload of medical staff and prevent the worsening of patient conditions by enabling timely interventions for PUs in the ICU.
Cadmium exposure of heavy metal-tolerant Mesembryanthemum crystallinum L. (the common ice plant) stimulates gas exchange

et al. 2019, Śliwa-Cebula et al. 2020, 2023). In the case of cadmium, it has been shown that M. crystallinum can accumulate and deposit this metal in plant organs at relatively high levels without showing any overt signs of damage (Nosek et al. 2019, 2020, Śliwa-Cebula et al. 2020). However, the effect of the Cd ion presence on the transpiration process and photosynthetic rate in the common ice plant has not been investigated, yet. It is well known that, when analyzing plant sensitivity/ tolerance to different stresses, photosynthetic activity plays a crucial role. In considering the mechanisms of the stress response, a key question arises whether they depend on the plant’s carboxylation potential (involving RubisCO, ribulose-1,5-bisphosphate carboxylase/oxygenase or PEPC, phosphoenolpyruvate carboxylase), or on photochemical activities connected with PSI and PSII function, along with the chloroplastic electron transport chain. Thus, it is important
Investigation of trends in basin-scale temperature variables

This research paper presents an analysis of temperature variables over the West Banas basin in order to detect the presence of underlying trends employing historical temperature data for three points viz., Abu Road, Mount Abu and Pindwara obtained for a period of 40 years (1981 – 2020) from MERRA-2 database. The study aims to investigate the long-term changes in temperature trends and identify any significant patterns or anomalies in mean, maximum and minimum temperatures at monthly, seasonal and annual timescales at the three locations amounting to a total of 162 series. The trends were evaluated using the Mann-Kendall test, a popular and powerful statistical technique formulated for analysing abnormal distributions. Prior to the application of the trend test, autocorrelated time series were identified and the trend test was modified using a variance correction approach to incorporate the influence of autocorrelations upon the resultant trends. The findings of autocorrelation analysis revealed that 11 of the 162 series were autocorrelated, a majority of which were associated with the temperature series at Abu Road. The results of the trend test showed that 27 out of the 162 series possessed significant trends with the mean and maximum monsoon temperatures in most of the series exhibiting a reducing trend while the minimum temperature appeared to be rising. Overall, the research highlights the importance of monitoring temperature trends, particularly in regions that may be more vulnerable to the impacts of climate change. The findings of this study can inform future climate adaptation strategies and support decision-making processes aimed at mitigating the effects of global warming on the natural and built environment.
Surface Geophysical Methods for Characterising Frozen Ground in Transitional Permafrost Landscapes

The distribution of shallow frozen ground is paramount to research in cold regions, and is subject to temporal and spatial changes influenced by climate, landscape disturbance and ecosystem succession. Remote sensing from airborne and satellite platforms is increasing our understanding of landscape‐scale permafrost distribution, but typically lacks the resolution to characterise finer‐scale processes and phenomena, which are better captured by integrated surface geophysical methods. Here, we demonstrate the use of electrical resistivity imaging (ERI), electromagnetic induction (EMI), ground penetrating radar (GPR) and infrared imaging over multiple summer field seasons around the highly dynamic Twelvemile Lake, Yukon Flats, central Alaska, USA. Twelvemile Lake has generally receded in the past 30 yr, allowing permafrost aggradation in the receded margins, resulting in a mosaic of transient frozen ground adjacent to thick, older permafrost outside the original lakebed. ERI and EMI best evaluated the thickness of shallow, thin permafrost aggradation, which was not clear from frost probing or GPR surveys. GPR most precisely estimated the depth of the active layer, which forward electrical resistivity modelling indicated to be a difficult target for electrical methods, but could be more tractable in time‐lapse mode. Infrared imaging of freshly dug soil pit walls captured active‐layer thermal gradients at unprecedented resolution, which may be useful in calibrating emerging numerical models. GPR and EMI were able to cover landscape scales (several kilometres) efficiently, and new analysis software showcased here yields calibrated EMI data that reveal the complicated distribution of shallow permafrost in a transitional landscape. Copyright © 2016 John Wiley & Sons, Ltd.
Diversity, Ecology, And Conservation Of Bird Communities Of Polylepis Woodlands In The Northern Andes Of Peru

The tropical Andes are recognized as one of the most diverse places in the world. Yet, our understanding of the extent to which elevation and seasonality drive diversity in the High Andes (>3,500 m) remains incomplete, despite that climate change is expected to both alter and threaten montane ecosystems. In this study, I described seasonal patterns of avian species richness in Polylepis forests distributed along an elevational gradient (~3,300 – 4,700 m) in five glacial valleys in Huascaran National Park, within the Cordillera Blanca range of Peru. In 2014-2015, birds were surveyed at 130 point count locations and systematically observed between points during wet and dry seasons. Number of species expected (S(est)) was calculated using the asymptotic Abundance-Coverage Estimator (ACE) for valleys, seasons, and within 100-m elevational bands. An estimated 70 to 100 species occupied each of the five glacial valleys, with 10 bird species dominating over half of the individuals recorded in communities. Species richness was lower in dry than wet seasons, particularly at lower elevations (<3,800 m). Reductions in species richness during the dry season were least likely to occur at high elevations in areas with Polylepis forest remnants. Species richness peaked at mid-elevations for the bird community overall and for three guilds (nectarivores, granivores and aerial insectivores), and was highest at ~4,000 m. Number of frugivorous species decreased with elevation, whereas terrestrial insectivores increased. The greatest number of endemics and threatened species, which primarily were Polylepis specialists, were found at ~4,300 m. The high estimates of species richness,
Accounting, Charities and local government in modern Italy: the case of the Congrega della carità apostolica in Brescia

Within the framework of the social charity systems born in Italy during the modern age, the case of Brescia stands out because of its complexity and of the presence of a significant charitable organization denominated Congrega della carita apostolica (CCA). Initially aimed at addressing the needs of the shamefaced poor - i.e. of those impoverished people who could no longer preserve the lifestyle of the social status they had previously enjoyed - in the early 20th century, this organization was the largest urban charity institution in the Kingdom of Italy. This paper aims to outline its institutional profile, the organizational and governance forms adopted and - especially - the accounting and internal and external control practices used in both ordinary and extraordinary administration, with reference to the years between the 19th and the 20th centuries - a period in the history of Italy that was crucial, due to the great economic, social and political transformation it brought about. This research has been supported by an extensive historical archive, which offers valid opportunities for deeper investigation in the future.
“It doesn’t feel like exercise”: a realist process evaluation of factors that support long-term attendance at dance classes designed for healthy ageing

Introduction Dance can positively impact older people’s health and wellbeing across cultures and socioeconomic groups, countering age-related physical, sensorimotor and cognitive decline. Background/objectives The RIPE (Really Is Possible for Everyone) Dance program aims to improve older people’s physical, mental, cognitive and social wellbeing by integrating engaging dance sequences with evidence-based fall prevention exercises. We sought to identify what mechanisms support observed long-term participation in this program, including by people living with challenging health conditions. Methods Following a realist evaluation approach, we co-developed and tested program theories iteratively with participant interviewees (n = 20), dance teachers (n = 2) and via observation of a dance class. Initial data were dual-coded and emergent findings were interrogated by the research team. Findings were organised to express Program activities + Context + Mechanism = Process outcomes configurations. Results We identified four program theories comprising 14 mechanisms which explained long-term attendance: 1. RIPE Dance benefits my body and mind (trust in the program, belief in health benefits), 2. RIPE Dance helps me feel good about myself (self-efficacy, pride in achievement, psychological safety, defying expectations, feeling valued), 3. RIPE Dance creates camaraderie (social connection, mutual support, rapport with the teacher), and 4. RIPE Dance is uplifting (raised spirits, fun, synchrony, musical reactivity). Conclusion The RIPE Dance program provides effective and enjoyable ‘exercise in disguise’ for older people with diverse mobility profiles. Significance/implications This research confirms that participation in dance can contribute significantly to healthy, happy ageing. Findings detail program activities that were most strongly associated with process outcomes, offering guidance for further program development, implementation and scaling up.
Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

Abstract Background Survival outcomes for glioblastoma (GBM) patients remain unfavorable, and tumor recurrence is often observed. Understanding the radiological growth patterns of GBM could aid in improving outcomes. This study aimed to examine the relationship between contrast-enhancing tumor growth direction and white matter, using an image registration and deformation strategy. Methods In GBM patients 2 pretreatment scans (diagnostic and neuronavigation) were gathered retrospectively, and coregistered to a template and diffusion tensor imaging (DTI) atlas. The GBM lesions were segmented and coregistered to the same space. Growth vectors were derived and divided into vector populations parallel (Φ = 0–20°) and perpendicular (Φ = 70–90°) to white matter. To test for statistical significance between parallel and perpendicular groups, a paired samples Student’s t-test was performed. O6-methylguanine-DNA methyltransferase (MGMT) methylation status and its correlation to growth rate were also tested using a one-way ANOVA test. Results For 78 GBM patients (mean age 61 years ± 13 SD, 32 men), the included GBM lesions showed a predominant preference for perineural satellitosis (P < .001), with a mean percentile growth of 30.8% (95% CI: 29.6–32.0%) parallel (0° < |Φ| < 20°) to white matter. Perpendicular tumor growth with respect to white matter microstructure (70° < |Φ| < 90°) showed to be 22.7% (95% CI: 21.3–24.1%) of total tumor growth direction. Conclusions The presented strategy showed that tumor growth direction in pretreatment GBM patients correlated with white matter architecture. Future studies with patient-specific DTI data are required to verify the accuracy of this method prospectively to identify its usefulness as a clinical metric in pre and posttreatment settings.
Quality of Life of Young Gastric Cancer Survivors: An Interpretation in the Context of Our Society

Background and Objectives: This retrospective case-control study aimed to investigate the quality of life (QoL) of young gastric cancer survivors and determine what should be pursued to obtain the best QoL for them after surgery. Materials and Methods: Patients with stage I gastric cancer who underwent distal subtotal gastrectomy were included. The European Organization for Research and Treatment of Cancer Quality of Life questionnaires were used to assess QoL. The QoL outcomes of younger (age 30–49 years, n = 76) and older (age 50–69 years, n = 232) groups were compared preoperatively, 3 months, and 1 year postoperatively. Results: There was no statistically significant difference in the preoperative QoL except for the physical functioning scale, which favored the younger group (p = 0.020). This difference remained significant throughout the postoperative periods (3 months, p = 0.002; 1 year, p = 0.004). Better QoL was found for the younger group according to the body image scale (p = 0.031). However, it was limited to the 3-month postoperative assessment. Persistent QoL disadvantages for the younger group were revealed by the diarrhea scale at the 3-month (p = 0.007) and 1-year (p = 0.005) postoperative assessments. Conclusions: While young gastric cancer survivors enjoyed better QoL in physical functioning and body image, worse QoL was related to diarrhea after surgery. Despite ever-rising concerns about QoL deterioration in elderly patients in our aged society, young gastric cancer survivors also need QoL support.
Infective Endocarditis: Inflammatory Response, Genetic Susceptibility, Oxidative Stress, and Multiple Organ Failure

Infective endocarditis is defined by a focus of infection within the heart. Despite the optimal care, the mortality approaches 30% at 1 year, so the care for this type of patients represents a challenge to improve the result in your care. The challenges in this clinical entity have several aspects such as the diversity of germs that cause endocarditis, and the most important epidemiologically has generated resistance to antimicrobial treatment along with the possibility of apoptosis in their host-germ interaction. The immunogenetic susceptibility to host infection is discussed, which represents a deep area of research. Inflammation, local and systemic, is complex, with the genesis of reactive oxygen species, which are harmful when the antioxidant defenses are exceeded, causing the break in the mitochondrial electron transport chain with the fall in energy genesis, multiple organ failure, and death. Both at the cellular level and in the mitochondria, possible therapeutic targets are also commented.