Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative

explore. The course will begin by reviewing Foucault's final lectures on parrhesia and "the courage of truth. " It will then examine some of the ancient Greek and Christian texts that Foucault analyzed. It will go on to consider early modern instances of parrhesia (e.g. Galileo and Descartes) and will conclude by surveying relatively recent versions (e.g. Greta von Thunberg and James Comey, JD'85), including contemporary feminist and queer practices of parrhesia. Lectures and discussions in English. No prerequisites. and they in and philosophy the to the present. This course introduces students to the foundational concepts for the critical study of race and religion through exploring the constructions of Black and Jewish identity. We examine the contradictions of secular politics and culture in and the United States, and discuss how religion, race, and intersecting categories such as gender and sexuality, can become tools of critique. Readings works by and Foucault, along with contemporary critical and Talal Asad. Throughout this course, we will examine how the concepts of race and components of the political, philosophical and ethical projects of these authors. No prerequisite knowledge of critical theory, or this historical period, is expected. erotic desires and sexual practices intersect with our beliefs? This interdisciplinary class explores these questions in conversation with foundational thinkers from the Islamic tradition alongside insights from feminist and queer theory. We will delve into questions on the relationship between romantic, familial, and divine love; gender, sexuality, and the body; and Orientalism and the politics of reading desire cross-culturally. Exploring a diverse set of primary sources that range from the Qur'ān to Rūmī's Masnāvī to contemporary Bollywood, we will encounter different representations of love, desire, and sexuality in religious and philosophical discourses, literary representations, and visual media. We will examine not only how these representations reflect different historical norms, but also how and to what extent texts and images can inform or impact the norms of their contexts as well. No prerequisite knowledge of the topics or time periods discussed is needed, and students will have the opportunity over the course of the class to develop a project that relates our content to their own interests. exemplars of autotheory and autofiction in light of exemplars from earlier phases of modernity. Readings will include: Fernando Pessoa, Virginia Woolf, Jorge Luis Borges, Roland Barthes, Robert Glück, Lyn Hejinian, Clarice Lispector, Rachel Cusk, Cecilia Vicuña, Paul Preciado, Gloria Anzaldúa, and Raquel Salas-Rivera. All readings will be in English, although there will be an opportunity to discuss texts in French and Spanish in the original language.Instructor(s):
Polar observations of convection with northward interplanetary magnetic field at dayside high latitudes

This study of dayside electrodynamics provides a first view of quasi-dc electric fields measured by Polar at middle altitudes. Three high-latitude passes chosen for analysis, occurred while Polar was in the midday sector and the interplanetary magnetic field (IMF) maintained a steady northward orientation at clock angles near 40° in the YGSM – ZGSM plane. At different times during the passes, Polar encountered electron and ion fluxes from the central plasma sheet (CPS), the boundary plasma sheet, the polar rain, and various magnetospheric boundary regions. Although electric fields measured within the boundary layers were highly variable, we derived average components of plasma convection. The results compare favorably with convection characteristics of four-cell patterns observed at ionospheric altitudes with northward IMF. We show that Polar encountered lobe cells of both positive and negative polarity in the early postnoon sector. The negative potential extends well into the prenoon sector. Inverse, energy-dispersed fluxes of He++ were detected in regions of sunward convection. Sunward convection extended into the region of polar rain north of the merging line's projection. The magnetic merging signatures indicate that the process is both time varying and patchy. Particle and field measurements are consistent with the afternoon, auroral convection cell closing in the low-latitude boundary layer, which extend many tens of RE tailward of the dusk terminator. Taken in a larger context, the Polar measurements provide new insight concerning the evolution of high-latitude convection from distorted two-cell patterns at large IMF clock angles to four cells at low clock angles.
Strategic Delegation Under Cost Asymmetry

We revisit the two-stage duopoly game with strategic delegation and asymmetric technologies of Sen and Stamatopoulos (2015). We show that their conclusions are driven by the restrictive assumption that the extent of delegation to managers is confined to a binary set. Allowing for a continuous set of delegation incentives, we prove that the delegation stage is a prisoners' dilemma, the unique subgame perfect equilibrium entailing both firms hiring managers. At equilibrium, the more efficient firm makes higher profits.
Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes

Transcription factors TFIIB and TFIIF are both required for RNA polymerase II preinitiation complex (PIC) assembly, but their roles at and downstream of initiation are not clear. We now show that TFIIF phosphorylated by casein kinase 2 remains competent to support PIC assembly but is not stably retained in the PIC. PICs completely lacking TFIIF are not defective in initiation or subsequent promoter clearance, demonstrating that TFIIF is not required for initiation or clearance. Lack of TFIIF in the PIC reduces transcription levels at some promoters, coincident with reduced retention of TFIIB. TFIIB is normally associated with the early elongation complex and is only destabilized at +12 to +13. However, if TFIIF is not retained in the PIC, TFIIB can be lost immediately after initiation. TFIIF therefore has an important role in stabilizing TFIIB within the PIC and after transcription initiates.
Leveraging an Electronic Medical Record to Improve Compliance with Pediatric Asthma Care Documentation

Asthma is our institution’s third most common admitting diagnosis with 653 admissions in 2011. The Joint Commission monitors core measures of pediatric asthma care during hospitalization: (1) were relievers given (2) were systemic corticosteroids given and (3) was the patient discharged with a complete asthma action plan (AAP). We describe the sue of three standard quality improvement (QIP) cycles to improve compliance using a computerized AAP. Our historical compliance using paper documentation averaged 32%. In Phase 1, we replaced the paper AAP form with an electronic version within our Electronic Medical Record (EMR) and improved our average compliance to 45%. In Phase 2, we identified barriers to additional improvement and modified the electronic form with soft stops and visual reminders. These modifications improved our compliance to 70%. In Phase 3, we identified remaining barriers, modified the form to include automated decision support and defaulting and improved our compliance to 90%. Using this phased QIP, we were able to achieve significant improvement in overall compliance with the core measure of providing an accurate and complete asthma action plan at the time of hospital discharge. With additional QIP cycles, we believe achievement of 100% documentation compliance for this core measure is possible.
Characterization and Identification of cis-Regulatory Elements in Arabidopsis Based on Single-Nucleotide Polymorphism Information[W][OPEN]

Information on genomic variation provided by novel sequencing technologies offers new and powerful approaches to identify regulatory elements and characterize gene promoter sequences. Identifying regulatory elements and revealing their role in gene expression regulation remains a central goal of plant genome research. We exploited the detailed genomic sequencing information of a large number of Arabidopsis (Arabidopsis thaliana) accessions to characterize known and to identify novel cis-regulatory elements in gene promoter regions of Arabidopsis by relying on conservation as the hallmark signal of functional relevance. Based on the genomic layout and the obtained density profiles of single-nucleotide polymorphisms (SNPs) in sequence regions upstream of transcription start sites, the average length of promoter regions in Arabidopsis could be established at 500 bp. Genes associated with high degrees of variability of their respective upstream regions are preferentially involved in environmental response and signaling processes, while low levels of promoter SNP density are common among housekeeping genes. Known cis-elements were found to exhibit a decreased SNP density than sequence regions not associated with known motifs. For 15 known cis-element motifs, strong positional preferences relative to the transcription start site were detected based on their promoter SNP density profiles. Five novel candidate cis-element motifs were identified as consensus motifs of 17 sequence hexamers exhibiting increased sequence conservation combined with evidence of positional preferences, annotation information, and functional relevance for inducing correlated gene expression. Our study demonstrates that the currently available resolution of SNP data offers novel ways for the identification of functional genomic elements and the characterization of gene promoter sequences.
Golgi-associated anion exchanger, AE2 : identification, cell type specific targeting and structural role in the Golgi complex

Anion exchanger 2 (AE2) is a member of the anion exchanger gene family, which includes three additional members, AE1, AE3, and AE4. They are also known as Na+-independent Cl/HCO3 exchangers, and their major function is to regulate intracellular pH and chloride concentration. All four isoforms have several N-terminally truncated variants that are often expressed cell type specifically. Red blood cells express the full-length AE1 isoform that interacts with ankyrin, an adapter protein linking plasma membrane to the spectrin-based membrane skeleton. This membrane skeleton association is essential for maintaining the membrane integrity of red blood cells. AE3 variants are mainly found in the brain and heart, whereas AE4 is localized in the kidney. Anion exchanger 2 is expressed in every cell line and tissue studied thus far, and it has been mainly localized to the plasma membrane. However, we found two types of localization/targeting of the AE2 protein in several of the cell lines studied. The protein was localized to either the plasma membrane or the Golgi complex, depending on the cell type. The AE2 variant expressed in these cells was identified as the full-length AE2 protein. The determinants of differential intracellular targeting were assessed. We hypothesized that Golgi-AE2 is anchored to the Golgi membranes via its association with the Golgi membrane skeleton. We were able to show that the Golgi localization of AE2 correlated with the cell type specific expression of Ank195, a Golgi membrane skeletal protein. In cells where AE2 was targeted to the plasma membrane, Ank195 was not expressed. In addition, the detergent insolubility and coredistribution properties of AE2 and Ank195 strongly suggested that these proteins interact with each other. The Golgi membrane skeleton has been shown to be necessary for maintaining the Golgi structure. Our studies were consistent with these findings, showing that in cells in which AE2 expression was reduced by using AE2-specific antisense oligonucleotides, the Golgi complex was dispersed. The spectrin-based membrane skeleton was probably partially detached from the Golgi membranes leading to breakdown of the Golgi structure and disorganization of the microtubules associated with it. The present findings suggest that the targeting of AE2 is cell type specific, and that Golgilocalized AE2 serves as a membrane association site for the spectrin-based Golgi membrane skeleton, thereby participating in the maintenance of the Golgi structure.
New Applications of Formal Concept Analysis : A Need for Original Pattern Domains

We survey the results obtained by our research group (joint work with Jérémy Besson and Löıc Cerf, Kim-Ngan T. Nguyen, Marc Plantevit, and Céline Robardet) concerning the design of pattern domains to support knowledge discovery and information retrieval in arbitrary n-ary relations. Our contribution is related to Formal Concept Analysis and its recent developments in direction of, for instance, Triadic Concept Analysis. We focus on a real data mining perspective. It means that we need for both the design of scalable constraint-based mining algorithms and fault-tolerant approaches to support the discovery of relevant patterns from noisy data.
The Approximability of Three-valued MAX CSP

In the maximum constraint satisfaction problem (MAX CSP), one is given a finite collection of (possibly weighted) constraints on overlapping sets of variables, and the goal is to assign values from a given domain to the variables so as to maximize the number (or the total weight, for the weighted case) of satisfied constraints. This problem is NP-hard in general, and, therefore, it is natural to study how restricting the allowed types of constraints affects the approximability of the problem. It is known that every Boolean (that is, two-valued) MAX CSP with a finite set of allowed constraint types is either solvable exactly in polynomial time or else APX-complete (and hence can have no polynomial-time approximation scheme unless P=NP). It has been an open problem for several years whether this result can be extended to non-Boolean MAX CSP, which is much more difficult to analyze than the Boolean case. In this paper, we make the first step in this direction by establishing this result for MAX CSP over a three-element domain. Moreover, we present a simple description of all polynomial-time solvable cases of our problem. This description uses the well-known algebraic combinatorial property of supermodularity. We also show that every hard three-valued MAX CSP contains, in a certain specified sense, one of the two basic hard MAX CSPs which are the Maximum k-Colorable Subgraph problems for k=2,3.
Constraints on the Validity of Equilibrium and First-Order Kinetic Transport Models in Structured Soils

Solutions are presented for solute transport in a system of spherical aggregates for flux concentrations Cf and for resident concentrations in mobile and immobile zones and in the bulk porous medium subject to continuous injection or pulse injection of infinitesimal or finite duration. By equating second moments of Cf versus time for the bicontinuum spherical diffusion model (SD) with those of a monocontinuum model which assumes local equilibrium (LE), an expression for the apparent dispersion coefficient De in the LE model is obtained in terms of physically meaningful SD model parameters, i.e., aggregate size, diffusion coefficient, etc. Constraints on the validity of the LE model are derived by evaluating differences Δμ3LE between third moments of Cf versus a temporal variable normalized by the mean residence time. The expression for Δμ3LE indicates the manner in which SD-LE model deviation decreases with diminishing aggregate size and immobile zone retardation factor and with increasing mobile zone retardation, mobile pore fraction, and distance from source. For continuous injection Δμ3LE = 0.01 generally yields close correspondence between SD and LE models when appropriate De values are used in the latter. For pulse injection of diminising duration, criteria for the degeneration of the SD model to the LE model become more stringent. The SD model is also compared to a first-order kinetic (FO) model to evaluate constraints on the latter in structured soils. Equating second moments of SD and FO models yields an expression for the apparent first-order rate coefficient in terms of SD model parameters. Comparison of third moments yields a criterion Δμ3FO for SD-FO model equivalence. A comparison of the error criteria for SD-FO and SD-LE equivalence indicates that the FO model always represents the diffusional kinetics more accurately than the LE model when near-equilibrium conditions prevail. Surprisingly, for severe nonequilibrium conditions, the LE model may in some instances approximate the SD model results more accurately than the FO model.
An innovative tsunami detector operating in tsunami generation environment

On August 25th 2007 a tsunami detector installed onb oard the multi-parameter observatory GEOSTAR was succes sfully deployed at 3200 b. s. l. in the Gulf of Cadiz, Portugal. This activity is within the NEAREST EC Proje ct (http://nearest.bo.ismar.cnr.it/ ). Among other de liverables, the NEAREST project will produce and test the basic parts of an op erational prototype of a near field tsunami warning syst em. This system includes an onshore warning centre, base d on the geophysical monitoring networks which are alrea dy operating, and a tsunami detector installed on boa rd GEOSTAR. On land the warning centre is in charge of collecting, integrating, and evaluating data recorded at sea. At the sea botto m, data are recorded and processed by an advanced type of tsunami detector which includes a pressure sensor, a seismometer and two accelerometers. The detector comm unicates acoustically with a surface buoy in two-way mode. The buoy is equipped with me teo station, GPS and tiltmeter and is connected to a sh ore station via satellite dual-link. The prototype is designed to operate in tsunami generation areas for det ection-warning purpose as well as for scientific measureme nts. The tsunami detector sends a near real time automatic alert message w hen a seismic or pressure threshold are exceeded. Press ure signals are processed by the tsunami detection algo rithm and the water pressure perturbation caused by the seafloor motion is taken into account. The algorithm is de igned to detect small tsunami waves, less than one centimetre, in a very noi sy environment. Our objective is to combine a novel appro ach to the tsunami warning problem, with a study of the coupling between the water column perturbations and sea floor motion, together with the long term monitoring of geophysical, geochemical and oceanographic parameters.
Result-size estimation for information-retrieval subqueries

Estimating the approximate result size of a query before its execution based on small summary statistics is important for query optimization in database systems and for other facets of query processing. This also holds for queries over text databases. Research on selectivity estimation for such queries has focused on Boolean retrieval, i.e., a document may be relevant for the query or not. But with the coalescence of database and information retrieval (IR) technology, selectivity estimation for other, more sophisticated relevance functions is gaining importance as well. These models generate a query-specific distribution of the documents over the [0, 1]-interval. With document distributions, selectivity estimation means estimating how many documents are how similar to a given query. The problem is much more complex than selectivity estimation in the Boolean context: Beside document frequency, query results also depend on other characteristics such as term frequencies and document lengths. Selectivity estimation must take them into account as well. This paper proposes and evaluates a technique for estimating the result of retrieval queries with non-Boolean relevance functions. It estimates discretized document distributions over the range of the relevance function. Despite the complexity, compared to Boolean selectivity estimation, it requires little additional data, and the additional data can be stored in existing data structures with little extensions. Our evaluation demonstrates the effectiveness of our technique.
Genomic Makeup of the Marine Flavobacterium Nonlabens (Donghaeana) dokdonensis and Identification of a Novel Class of Rhodopsins

Rhodopsin-containing marine microbes such as those in the class Flavobacteriia play a pivotal role in the biogeochemical cycle of the euphotic zone (Fuhrman JA, Schwalbach MS, Stingl U. 2008. Proteorhodopsins: an array of physiological roles? Nat Rev Microbiol. 6:488–494). Deciphering the genome information of flavobacteria and accessing the diversity and ecological impact of microbial rhodopsins are important in understanding and preserving the global ecosystems. The genome sequence of the orange-pigmented marine flavobacterium Nonlabens dokdonensis (basonym: Donghaeana dokdonensis) DSW-6 was determined. As a marine photoheterotroph, DSW-6 has written in its genome physiological features that allow survival in the oligotrophic environments. The sequence analysis also uncovered a gene encoding an unexpected type of microbial rhodopsin containing a unique motif in addition to a proteorhodopsin gene and a number of photolyase or cryptochrome genes. Homologs of the novel rhodopsin gene were found in other flavobacteria, alphaproteobacteria, a species of Cytophagia, a deinococcus, and even a eukaryote diatom. They all contain the characteristic NQ motif and form a phylogenetically distinct group. Expression analysis of this rhodopsin gene in DSW-6 indicated that it is induced at high NaCl concentrations, as well as in the presence of light and the absence of nutrients. Genomic and metagenomic surveys demonstrate the diversity of the NQ rhodopsins in nature and the prevalent occurrence of the encoding genes among microbial communities inhabiting hypersaline niches, suggesting its involvement in sodium metabolism and the sodium-adapted lifestyle.
Dynamic Time Warping and Geometric Edit Distance

Dynamic Time Warping (DTW) and Geometric Edit Distance (GED) are basic similarity measures between curves or general temporal sequences (e.g., time series) that are represented as sequences of points in some metric space (X, dist). The DTW and GED measures are massively used in various fields of computer science and computational biology. Consequently, the tasks of computing these measures are among the core problems in P. Despite extensive efforts to find more efficient algorithms, the best-known algorithms for computing the DTW or GED between two sequences of points in X = Rd are long-standing dynamic programming algorithms that require quadratic runtime, even for the one-dimensional case d = 1, which is perhaps one of the most used in practice. In this article, we break the nearly 50-year-old quadratic time bound for computing DTW or GED between two sequences of n points in R by presenting deterministic algorithms that run in O(n2 log log log n/ log log n) time. Our algorithms can be extended to work also for higher-dimensional spaces Rd, for any constant d, when the underlying distance-metric dist is polyhedral (e.g., L1, Linfin).