Miracle-dz/UniFAR-FTUs huggingface dataset:
Perfect Absorber Metamaterial for Designing Low-RCS Patch Antenna

Perfect absorber metamaterial (PAM) to reduce antenna radar cross section (RCS) is proposed. The novel low-RCS antenna is based on the concept of the PAM consisting of a periodic array of metallic dendritic structure and metallic square film etched on each face of a single substrate. The PAM processes high electromagnetic wave absorptivity for a wide incident angle. In the present letter, the PAM patterns are printed on the surface of a patch antenna to reduce the antenna RCS. It is demonstrated that, as compared to an antenna without the PAM, the proposed antenna RCS can be reduced drastically due to the fact that the PAM absorbs electromagnetic wave. Meanwhile, the proposed antenna can still maintain good radiation characteristics.
Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response*

To investigate drug mechanisms of action and identify molecular targets for the development of rational drug combinations, we conducted synthetic small interfering RNA (siRNA)-based RNAi screens to identify genes whose silencing affects anti-cancer drug responses. Silencing of RRM1 and RRM2, which encode the large and small subunits of the human ribonucleotide reductase complex, respectively, markedly enhanced the cytotoxicity of the topoisomerase I inhibitor camptothecin (CPT). Silencing of RRM2 was also found to enhance DNA damage as measured by histone γ-H2AX. Further studies showed that CPT up-regulates both RRM1 and RRM2 mRNA and protein levels and induces the nuclear translocation of RRM2. The checkpoint kinase 1 (Chk1) was up-regulated and activated in response to CPT, and CHEK1 down-regulation by siRNA and small molecule inhibitors of Chk1 blocked RRM2 induction by CPT. CHEK1 siRNA also suppressed E2F1 up-regulation by CPT, and silencing of E2F1 suppressed the up-regulation of RRM2. Silencing of ATR or ATM and inhibition of ATM activity by KU-55933 blocked Chk1 activation and RRM2 up-regulation. This study links the known components of CPT-induced DNA damage response with proteins required for the synthesis of dNTPs and DNA repair. Specifically, we propose that upon DNA damage, Chk1 activation, mediated by ATM and ATR, up-regulates RRM2 expression through the E2F1 transcription factor. Up-regulation in RRM2 expression levels coupled with its nuclear recruitment suggests an active role for ribonucleotide reductase in the cellular response to CPT-mediated DNA damage that could potentially be exploited as a strategy for enhancing the efficacy of topoisomerase I inhibitors.
ACCELERATING IMPACTS OF TEMPERATURE-INDUCED CORAL BLEACHING IN THE CARIBBEAN

Coral bleaching is a stress-related response that can be triggered by elevated sea surface temperatures (SST). Recent increases in the frequency of coral bleaching have led to concerns that increases in marine temperatures may threaten entire coral reef regions. We report exponential increases in the geographical extent and intensity of coral bleaching in the Caribbean with increasing SST anomalies. A rise in regional SST of 0.1°C results in 35% and 42% increases in the geographic extent and intensity of coral bleaching, respectively. Maximum bleaching extent and intensity are predicted to occur at regional SST anomalies of less than +1°C, which coincides with the most conservative projections for warming in the Caribbean by the end of the 21st century. Coral bleaching is therefore likely to become a chronic source of stress for Caribbean reefs in the near future.
Improving gene recognition accuracy by combining predictions from two gene-finding programs

MOTIVATION Despite constant improvements in prediction accuracy, gene-finding programs are still unable to provide automatic gene discovery with desired correctness. The current programs can identify up to 75% of exons correctly and less than 50% of predicted gene structures correspond to actual genes. New approaches to computational gene-finding are clearly needed. RESULTS In this paper we have explored the benefits of combining predictions from already existing gene prediction programs. We have introduced three novel methods for combining predictions from programs Genscan and HMMgene. The methods primarily aim to improve exon level accuracy of gene-finding by identifying more probable exon boundaries and by eliminating false positive exon predictions. This approach results in improved accuracy at both the nucleotide and exon level, especially the latter, where the average improvement on the newly assembled dataset is 7.9% compared to the best result obtained by Genscan and HMMgene. When tested on a long genomic multi-gene sequence, our method that maintains reading frame consistency improved nucleotide level specificity by 21.0% and exon level specificity by 32.5% compared to the best result obtained by either of the two programs individually. AVAILABILITY The scripts implementing our methods are available from http://www.cs. ubc.ca/labs/beta/genefinding/
Suppression of Atomic Radiative Collisions by Tuning the Ground State Scattering Length

We investigate the radiative collision rate in an ultracold, optically trapped cesium gas near a magnetically tunable Feshbach resonance. The radiative trap loss is suppressed by a factor of up to 15 when the node of the ground state pair correlation function is tuned to the Condon point. This constitutes a direct measurement of both the sign and the magnitude of the s-wave scattering length. In addition, we observe several narrow, superimposed loss resonances. Their widths are determined by the gas temperature, and their positions are independent of external parameters to within 5 mG.
Role of Adenosine in Coronary Vasodilation During Exercise

This study examined the hypothesis that increases in myocardial blood flow during exercise are mediated by adenosine-induced coronary vasodilation. Active hyperemia associated with graded treadmill exercise and coronary reactive hyperemia were examined in chronically instrumented awake dogs during control conditions, after intracoronary infusion of adenosine deaminase (5 units/kg/min for 10 minutes), and after adenosine receptor blockade with 8-phenyltheophylline. Both adenosine deaminase and 8-phenyltheophylline caused a rightward shift of the dose-response curve to intracoronary adenosine; 8-phenyltheophylline was significantly more potent than adenosine deaminase. Adenosine deaminase caused a 33 ± 7 to 39 ± 3% decrease in reactive hyperemia blood flow following coronary occlusions of 5–20 seconds duration, respectively, while 8-phenyltheophylline produced a 40 ± 6 to 62 ± 8% decrease in reactive hyperemia. Increasing myocardial oxygen consumption during treadmill exercise was associated with progressive increases of coronary blood flow. Neither adenosine deaminase nor 8-phenyltheophylline attenuated the increase in coronary blood flow or the decrease of coronary vascular resistance during exercise. Neither agent altered the relation between myocardial oxygen consumption and coronary blood flow. Thus, although both adenosine deaminase and 8-phenyltheophylline antagonized coronary vasodilation in response to exogenous adenosine and blunted coronary reactive hyperemia, neither agent impaired coronary vasodilation associated with increased myocardial oxygen requirements produced by exercise. These findings fail to support a substantial role for adenosine in mediating coronary vasodilation during exercise.
A Fully Parameterizable Low Power Design of Vector Fused Multiply-Add Using Active Clock-Gating Techniques

The need for power-efficiency is driving a rethink of design decisions in processor architectures. While vector processors succeeded in the high-performance market in the past, they need a re-tailoring for the mobile market that they are entering now. Floating point fused multiply-add, being a power consuming functional unit, deserves special attention. Although clock-gating is a well-known method to reduce switching power in synchronous designs, there are unexplored opportunities for its application to vector processors, especially when considering active operating mode. In this research, we comprehensively identify, propose, and evaluate the most suitable clock-gating techniques for vector fused multiply-add units (VFU). These techniques ensure power savings without jeopardizing the timing. Using vector masking and vector multi-lane-aware clock-gating, we report power reductions of up to 52%, assuming active VFU operating at the peak performance. Among other findings, we observe that vector instruction-based clock-gating techniques achieve power savings for all vector floating-point instructions. We perform this research in a fully parameterizable and automated fashion using various tools at both architectural and circuit levels.
Postnatal exercise Post-partum Back pain Exercise Postnatal Low back pain Cardiovascular Birth Lumbago Pilates Mother Pelvic pain Yoga Maternal Pelvis pain Core stability Mum Sacroiliac pain Core strengthening Mom Postnatal pain Walking Post-partum pain Running Pelvic girdle pain Jogging

Postnatal low back pain (LBP) and pelvic pain can affect up to 82% of women at some point in the year after they have given birth. Sufferers often report pain of varying intensities, resulting in effects ranging from mild annoyance to severe disability. Neither LBP nor pelvic pain in the first year post-partum are clearly understood, but these problems are thought to be caused by a multitude of factors, including a previous history of LBP, back pain in pregnancy, hormonal changes, the postural changes associated with a new baby, tiredness and mood. This systematic review of the available randomized controlled trials (RCTs) that met certain inclusion and exclusion criteria analyses five studies of the effect of exercise on LBP and pelvic pain in the first year post-partum. All of these trials focused on abdominal strengthening. Two RCTs reported that exercise was associated with positive outcomes, but the remaining three studies concluded that it brought no additional benefit. Although the evidence suggests that abdominal exercise in the first year post-partum may provide some relief for women suffering from LBP and pelvic pain, more research of better methodological quality needs to be completed.
A Real-Time Video Stream Key Frame Identification Algorithm for QoS

As the rapid development of Internet technology and the deployment of Internet multimedia applications, it’s urgent to solve the QoS problems of the real-time multimedia services in the network for clients. This paper proposes a real-time video stream key frame identification algorithm for QoS, named RVKI. In this algorithm, the frame type of IP packets could be identified at the real-time multimedia server and be marked. This result can be used for some autonomic QoS management to improve the success of IP packets transmission to the client, which carrying real-time multimedia key frame information, while network congestion appeared but could not decrease the packet loss of this application. Test has shown that RVKI can effectively dissect key frame in the real-time multi-media stream and helpful for QoS.
Ship course-keeping adaptive Fuzzy controller design using command filtering with minimal parametrization

Ship course-keeping control is an important function for ship autopilot. This paper describes the application of adaptive backstepping theory to automatic steering of ships. The motivation for using fuzzy control theory is that nonlinearities can be compensated for in a systematic manner. In fact, nonlinear manoeuvering properties are observed for most large tankers. Furthermore, Its aim is to make ship course track the reference model's output. The controller can guarantee the ultimate uniform boundedness of the signals in closed-loop system. it is emphasized that The controller design is in the sense of minimal parametrization. That is, only one adaptive law learns the system's unknown parameters online. In order to bypass the iterative differential manipulations in conventional ship course-keeping backstepping adaptive controller, command filtering is used. Simulation researches take ship Yulong as an example. The results demonstrate that the controller design is effective. Finally, some simulation results are reported to demonstrate the usage and effectiveness of the control scheme.
Design and demonstration of paper-thin and low-warpage single and 3D organic packages with chip-last embedding technology for smart mobile applications

This paper presents innovations and advances in demonstrating paper-thin organic packages with low warpage. These advances include: 1) Reduction in over-all substrate warpage, 2) Ultra-low stand off interconnection height, 3) Ultra-thin (30 μm core thickness) and ultra-low CTE (1-5 ppm/°C) organic substrates, 4) Assembly of large die onto the ultra-thin substrate, and 5) Assembly to form advanced package-on-package using conventional batch-type SMT reflow processes. Design, fabrication, assembly and characterization of test-vehicles demonstrating all these innovations are described in this paper. Comprehensive warpage modeling is performed by taking into account all substrate fabrication and assembly steps. The measured warpage data after package fabrication and assembly was used to refine and validate the models. Optimized geometry and material parameters are designed from the validated models.
The emergence of pseudo-stable states in network dynamics

In the context of network dynamics, the complexity of systems increases possible evolutionary paths that often are not deterministic. Occasionally, some map routs form over the course of time which guide systems towards some particular states. The main intention of this study is to discover an indicator that can help predict these pseudo-deterministic paths in advance. Here we investigate the dynamics of networks based on Heider balance theory that states the tendency of systems towards decreasing tension. This inclination leads systems to some local and global minimum tension states called "jammed states" and "balanced states", respectively. We show that not only paths towards jammed states are not completely random but also there exist secret pseudo deterministic paths that bound the system to end up in these special states. Our results display that the Inverse Participation Ratio method (IPR) can be a suitable indicator that exhibits collective behaviors of systems. According to this method, these specific paths are those that host the most participation of the constituents in the system. A direct proportionality exists between the distance and the selectable paths towards local minimums; where by getting close to the final steps there is no other way but the one to the jammed states.
Cell Adhesion Mechanisms in Platelets

At sites of vascular injury, platelets come into contact with the subendothelial extracellular matrix which triggers their activation and the formation of a hemostatic plug. This process is crucial for normal hemostasis, but may also lead to pathological thrombus formation causing diseases such as myocardial infarction or stroke. The initial capture of flowing platelets is mediated by the interaction of the glycoprotein (GP) Ib-V-IX complex with von Willebrand factor (vWF) immobilized on exposed collagens. This interaction allows the binding of the collagen receptor GPVI to its ligand and to initiate cellular activation, a process that is reinforced by locally produced thrombin and soluble mediators released from platelets. These events lead to the shift of &bgr;1 and &bgr;3 integrins on the platelet surface from a low to a high affinity state, thereby enabling them to bind their ligands and to mediate firm adhesion, spreading, coagulant activity, and aggregation. This review summarizes the most important structural and functional properties of these adhesion receptors and briefly discusses their potential as targets for antithrombotic therapy.
The Anatomical Morphology of the Supraorbital Notch: Clinical Relevance to the Surgical Treatment of Migraine Headaches

Background: Current literature for surgical deactivation of frontal migraine trigger points does not incorporate decompression of the supraorbital foramen or fascial bands at the supraorbital rim (frontal exit) as part of the surgical procedure. To evaluate this primary compression site for the supraorbital nerve, anatomical dissections were performed and a classification system was developed. Methods: Sixty supraorbital regions from 30 ethylene glycol–preserved cadaveric heads were dissected. Particular attention was focused on the morphology of the supraorbital rim, specifically, the presence of a supraorbital notch or supraorbital foramen. The presence or absence of a fascial band completing the notch and the patterns of fascial band variations were documented. Results: A supraorbital foramen was identified 27 percent of the time and a notch was identified 83 percent of the time. When a notch was encountered, a fascial band forming the floor of the notch that completed the encirclement of the supraorbital nerve was noted in 86 percent of supraorbital regions. A classification system was developed to categorize the four common fascial band variation patterns observed. Conclusions: This study verifies the presence of a primary compression site for the supraorbital nerve that is proximal to the glabellar myofascial complex. Knowledge of this compression site and its possible anatomical variations will enable surgeons to perform a more complete supraorbital nerve decompression for migraine amelioration.
The ∂ Steepest Descent Method and the Asymptotic Behavior of Polynomials Orthogonal on the Unit Circle with Fixed and Exponentially Varying Nonanalytic Weights

The steepest descent method for asymptotic analysis of matrix Riemann-Hilbert problems was introduced by Deift and Zhou in 1993 [14]. A matrix Riemann-Hilbert problem is specified by giving a triple (Σ, v,N) consisting of an oriented contour Σ in the complex z-plane, a matrix function v : Σ → SL(N) which is usually taken to be continuous except at self-intersection points of Σwhere a certain compatibility condition is required, and a normalization condition N as z → ∞. If Σ is not bounded, certain asymptotic conditions are required of v in order to have compatibility with the normalization condition. Consider an analytic functionM : C \ Σ → SL(N) taking continuous boundary valuesM+(z) (resp., M−(z)) on Σ from the left (resp., right). The Riemann-Hilbert problem (Σ, v,N) is then to find such a matrix M(z) satisfying the normalization condition N as z → ∞ and the jump condition M+(z) = M−(z)v(z) whenever z is a non-self-intersection point of Σ (so the left and right boundary values are indeed well defined). The steepest descent method of Deift and Zhou applies to certain Riemann-Hilbert problems where the jumpmatrix v(z) depends on an auxiliary control parameter, and is a method for extracting asymptotic properties of the solution M(z) (and indeed proving the existence and
Usefulness of different techniques in the study of the epidemiology of salmonellosis

Our objective was to evaluate the usefulness of serotyping, phagotyping, antibiotyping and RAPD (random amplified polymorphic DNA) in the study of the epidemiology of salmonellosis in Elche (Spain). We examined 1232 clinical isolates of non‐typhoid Salmonella serotypes. Serotyping adequately differentiates 12.3% of the isolates and phagotyping raises this percentage to 37%. Antibiotyping is a suitable complement in certain circumstances, such as in the case of specific outbreaks. RAPD is a fast and simple technique which is within the reach of most laboratories, complementing the results obtained by antibiotyping and serotyping, in order to be able to control outbreaks of salmonellosis in everyday practice.
Analyzing the Composite 3-D Printer Frame for Rigidity

Additive Manufacturing offers a wide variety of options when it comes to the construction of a part. Different infill patterns, infill densities, varying shell thickness, and different materials all have different effects on the final strength of a functional 3D printed part. This paper studies the benefits of using a fused deposition modeling (FDM) process to print a part completely hollow and fill the completed hollow shell with epoxy resin to create a solid component. FDM is also known as fused filament fabrication (FFF). Often times, large functional FDM parts can take quite a long time to complete printing due to high strength setting requirements. Hollow parts can print much faster than parts with infill, then be filled with an epoxy resin to create a solid part in much less time. When cured, the resin filled components will produce a stronger and more rigid finished product than a printing the part with comparable print settings. To illustrate this, a 3D printer frame was designed, analyzed with an FEM simulation and fabricated.
Influence of Delivery Method on Neuroprotection by Bone Marrow Mononuclear Cell Therapy following Ventral Root Reimplantation with Fibrin Sealant

The present work compared the local injection of mononuclear cells to the spinal cord lateral funiculus with the alternative approach of local delivery with fibrin sealant after ventral root avulsion (VRA) and reimplantation. For that, female adult Lewis rats were divided into the following groups: avulsion only, reimplantation with fibrin sealant; root repair with fibrin sealant associated with mononuclear cells; and repair with fibrin sealant and injected mononuclear cells. Cell therapy resulted in greater survival of spinal motoneurons up to four weeks post-surgery, especially when mononuclear cells were added to the fibrin glue. Injection of mononuclear cells to the lateral funiculus yield similar results to the reimplantation alone. Additionally, mononuclear cells added to the fibrin glue increased neurotrophic factor gene transcript levels in the spinal cord ventral horn. Regarding the motor recovery, evaluated by the functional peroneal index, as well as the paw print pressure, cell treated rats performed equally well as compared to reimplanted only animals, and significantly better than the avulsion only subjects. The results herein demonstrate that mononuclear cells therapy is neuroprotective by increasing levels of brain derived neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF). Moreover, the use of fibrin sealant mononuclear cells delivery approach gave the best and more long lasting results.
Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.