Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the QAMAI tool to assess the quality of health information provided by AI.

Objective: To propose and validate the Quality Assessment of Medical Artificial Intelligence (QAMAI), a tool specifically designed to assess the quality of health information provided by AI platforms. Study design: observational and valuative study Setting. 27 surgeons from 25 academic centers worldwide. Methods: The QAMAI tool has been developed by a panel of experts following guidelines for the development of new questionnaires. A total of 30 responses from ChatGPT4, addressing patient queries, theoretical questions, and clinical head and neck surgery scenarios were assessed. Construct validity, internal consistency, inter-rater and test-retest reliability were assessed to validate the tool. Results: The validation was conducted on the basis of 792 assessments for the 30 responses given by ChatGPT4. The results of the exploratory factor analysis revealed a unidimensional structure of the QAMAI with a single factor comprising all the items that explained 51.1% of the variance with factor loadings ranging from 0.449 to 0.856. Overall internal consistency was high (Cronbach's alpha=0.837). The Interclass Correlation Coefficient was 0.983 (95%CI 0.973-0.991; F(29,542)=68.3; p<0.001), indicating excellent reliability. Test-retest reliability analysis revealed a moderate-to-strong correlation with a Pearson coefficient of 0.876 (95%CI 0.859-0.891; p<0.001) Conclusions: The QAMAI tool demonstrated significant reliability and validity in assessing the quality of health information provided by AI platforms. Such a tool might become particularly important/useful for physicians as patients increasingly seek medical information on AI platforms.
Effects of Preanalytical Sample Collection and Handling on Comprehensive Metabolite Measurements in Human Urine Biospecimens

Epidemiology studies evaluate associations between the metabolome and disease risk. Urine is a common biospecimen used for such studies due to its wide availability and non-invasive collection. Evaluating the robustness of urinary metabolomic profiles under varying preanalytical conditions is thus of interest. Here we evaluate the impact of sample handling conditions on urine metabolome profiles relative to the gold standard condition (no preservative, no refrigeration storage, single freeze thaw). Conditions tested included the use of borate or chlorhexidine preservatives, various storage and freeze/thaw cycles. We demonstrate that sample handling conditions impact metabolite levels, with borate showing the largest impact with 125 of 1,048 altered metabolites (adjusted P < 0.05). When simulating a case-control study with expected inconsistencies in sample handling, we predicted the occurrence of false positive altered metabolites to be low (< 11). Predicted false positives increased substantially (>= 63) when cases were simulated to undergo alternate handling. Finally, we demonstrate that sample handling impacts on the urinary metabolome were markedly smaller than those in serum. While changes in urine metabolites incurred by sample handling are generally small, we recommend implementing consistent handling conditions and evaluating robustness of metabolite measurements for those showing significant associations with disease outcomes.
EEG signatures at different propofol vs sevoflurane concentrations

The depth of anesthesia is contingent upon the concentration of administered hypnotics, but establishing an exact relationship proves challenging, given its variability among individual patients. To elucidate the connection between the depth of anesthesia and hypnotic concentration, we leverage transient EEG patterns specifically, isoelectric suppressions and power distributions within the alpha and delta frequency bands at constant concentrations. Our investigation focuses on two hypnotic: propofol and sevoflurane. In a cohort encompassing children and young adults undergoing general anesthesia, we employ segmentation algorithms to extract a diverse range of spectral representations in EEG profiles. However, as we systematically alter hypnotic concentrations, a consistent trend emerges: heightened hypnotic concentration predominantly aligns with increased delta band power and reduced alpha band power. Notably, the occurrence of isoelectric suppressions is primarily associated with elevated propofol concentrations and infrequently observed with high levels of sevoflurane. Furthermore, we observe a decrease in the maximal power frequency of the alphaband as hypnotic concentrations increase. In summary, this study offers a systematic quantification of EEG patterns corresponding to distinct concentrations of propofol and sevoflurane. These observed patterns contribute to a nuanced EEG representation of brain activity, laying the groundwork for personalized anesthesia strategies.
Task-based and Magnified Mirror Therapy for Unilateral Spatial Neglect among post-stroke subjects: Study protocol for a randomized controlled trial

Background Unilateral spatial neglect (USN) is a commonly occurring neurocognitive disability after a stroke. The neglect may affect the motor recovery of the upper and lower limbs and functional performances. Mirror therapy, a simple and economical approach has the potential to reduce the USN and related impairments. Aim The primary objective of this study is to determine the effectiveness of task-based and magnified mirror therapy on the USN and on the motor recovery of the post-stroke subjects. The secondary objective is to investigate the effectiveness of the intervention on the function and disability of the subjects. Methods In this randomized controlled, assessor-blinded trial, 86 post-stroke subjects will be recruited from the neuro-rehabilitation laboratory of a rehabilitation institute, located in northern India. The participants,aged20 to 80 years, with 1 to 36 months of stroke onset, hemiparesis, and the USN, will be considered eligible for the study. In addition to the conventional rehabilitation, the experimental group(n = 43) will receive 40 sessions (8 weeks) of Task-based and MAGnified Mirror Therapy for Unilateral Spatial Neglect (T-MAGUSN). The control group (n = 43) will undergo a dose-matched conventional program only. The participants will be assessed at baseline, post-intervention and 4-week follow-up using primary (Line Bisection Test, Letter Cancellation Test, and Fugl-Myer Assessment) and secondary (Catherine Bergego Scale, Berg Balance Scale, Functional Ambulation Classification, Modified Rankin Scale) outcome measures. Discussion This proposed study will lead to the development of a novel rehabilitation protocol for the management of USN, aiming to enhance motor and functional recovery. The investigation will consider both the upper and lower limbs for the intervention, reducing the impact of cognitive disability in stroke. Trial registration Clinical Trial Registry of India (CTRI) as CTRI/2023/05/053184 (www.ctri.nic.in/Clinicaltrials/pmaindet2.php? trialid=74659).
The development and validation of a digital biomarker for remote assessment of Alzheimer's diseases risk

Background Digital cognitive assessment is becoming increasingly widespread in ageing research and care, especially since the COVID-19 pandemic. Remote online collection provides opportunities for ageing and dementia professionals to collect larger datasets, increase the diversity of research participants and patients and offer cost-effective screening and monitoring methods for clinical practice and trials. However, the reliability of self-administered at-home tests compared to their lab-based counterparts often goes unexamined, compromising the validity of adopting such measures. Objective Our aim is to validate a self-administered web-based version of the visual short-term memory binding task (VSTMBT), a potential digital biomarker sensitive to Alzheimer's disease processes, suitable for use on personal devices. Methods A final cross-sectional sample of 37 older-adult (51–77 years) participants without dementia completed our novel self-administered version of the VSTMBT, both at home on a personal device and in the lab, under researcher-controlled conditions. Results ANOVA and Bayesian t-test found no significant differences between the task when it was remotely self-administered by participants at home compared to when it was taken under controlled lab conditions. Conclusions These results indicate the VSTMBT can provide reliable data when self-administered at-home using an online version of the task and on a personal device. This finding has important implications for remote screening and monitoring practices of older adults, as well as supporting clinical practices serving diverse patient communities. Future work will assess remote administration in older adults with cognitive impairment and diverse socio-economic and ethno-cultural backgrounds as well as a bench-to-bedside application.
Combining and segmenting geometric shapes into parts depending on symmetry type: Evidence from children and adults

Symmetry is an important geometric feature that affects object segmentation into parts, though De Winter and Wagemans note that partly occluded objects can still be identified by the remaining visible parts. In two sets of experiments with children (n = 31, age 7–11, M = 8.8, SD = 1.4) and adults (n = 19, age 17–57, M = 30.4, SD = 12.6), we used 13 basic geometric figures distinguished by symmetry types to test how they are naturally segmented or combined and what the developmental impacts are on the segmentation and combination. In the first experiment, participants were asked to cut figures into two along a straight line; in the second experiment, participants had to create five sets of connected two-figure combinations where overlapping figures were allowed. The results confirmed the importance of the symmetry axis in both tasks. Other relevant criteria were dividing into half, maximal/minimal curvature, and use of edges or corners for reference. This study allows comparisons of the impact of symmetry type on the segmentation and combining of geometric figures and indicates developmental differences between children and adults.
Bessel smoothing filter for spectral-element mesh

S U M M A R Y Smoothing filters are extremely important tools in seismic imaging and inversion, such as for traveltime tomography, migration and waveform inversion. For efficiency, and as they can be used a number of times during inversion, it is important that these filters can easily incorporate prior information on the geological structure of the investigated medium, through variable coherent lengths and orientation. In this study, we promote the use of the Bessel filter to achieve these purposes. Instead of considering the direct application of the filter, we demonstrate that we can rely on the equation associated with its inverse filter, which amounts to the solution of an elliptic partial differential equation. This enhances the efficiency of the filter application, and also its flexibility. We apply this strategy within a spectral-element-based elastic full waveform inversion framework. Taking advantage of this formulation, we apply the Bessel filter by solving the associated partial differential equation directly on the spectralelement mesh through the standard weak formulation. This avoids cumbersome projection operators between the spectral-element mesh and a regular Cartesian grid, or expensive explicit windowed convolution on the finite-element mesh, which is often used for applying smoothing operators. The associated linear system is solved efficiently through a parallel conjugate gradient algorithm, in which the matrix vector product is factorized and highly optimized with vectorized computation. Significant scaling behaviour is obtained when comparing this strategy with the explicit convolution method. The theoretical numerical complexity of this approach increases linearly with the coherent length, whereas a sublinear relationship is observed practically. Numerical illustrations are provided here for schematic examples, and for a more realistic elastic full waveform inversion gradient smoothing on the SEAM II benchmark model. These examples illustrate well the efficiency and flexibility of the approach proposed.
Cutaneous mycobacteriosis caused by Mycobacterium avium subspecies avium in a dog: Clinical findings, histopathological and molecular diagnosis and treatment

Abstract A 3‐year‐old castrated male Jack Russell Terrier with a history of cholestatic hepatitis was presented with a non‐painful and non‐pruritic, subcutaneous nodule following vaccine injection. The dog was otherwise healthy. The nodule was surgically removed. Upon gross inspection, a firm, glistening and loculated tissue was seen within the panniculus. Histopathologically, extensive pyogranulomatous panniculitis was diagnosed, composed of variably sized lipocyst surrounded by neutrophils and an outer zone of foamy epithelioid macrophages, neutrophils and occasional Langhans form giant cells. Although histopathologic findings were most compatible with mycobacteriosis, other infectious and sterile conditions were considered differential diagnoses. Gram, acid‐fast and periodic acid Schiff staining were negative. However, PCR analyses for mycobacterial rpoB gene and sequencing revealed infection with Mycobacterium avium subsp. avium. Empirical treatment was avoided through the 3‐week course of histopathological and molecular investigations. Considering that there were no newly formed cutaneous masses, marbofloxacin (2 mg/kg, PO q24h) was administered for 2 weeks, and clarithromycin was avoided due to its potential cholestatic hepatitis adverse effects. Eight months following surgery, there are no new or relapsing cutaneous lesions or disease‐specific complications. This suggests that marbofloxacin monotherapy may be sufficient in immunocompetent dogs with early detection of localized cutaneous mycobacteriosis lacking lymph node or organ involvement.
Seroprevalence of small ruminant brucellosis in the state of Qatar

Abstract Background Brucellosis is one of the most important zoonotic diseases worldwide, with a significant economic and health burden. The disease is endemic in many regions around the world. Data regarding the disease in the Arabic Gulf region is scarce, and a limited number of studies have been conducted in Qatar. This study is the first to investigate the seroprevalence of small ruminant brucellosis in the state of Qatar. Methods The country was divided into three zones based on animal population (high, medium and low). A total of 494 blood samples from 57 small ruminant flocks were randomly collected from the three zones. Rose Bengal and competitive enzyme‐linked immunosorbent assay were used to investigate the apparent and true seroprevalence at both the animal and flock levels. A regression model was used to investigate the potential risk factors, including geographic zone, sex and age. Results At the animal level, the overall (sheep and goat) apparent and true seroprevalence were 9.6% (95% confidence interval [95% CI]: 7.3–12.5) and 8.4% (95% CI: 5.9–11.5), respectively. In sheep, the apparent seroprevalence was 16.7% (95% CI: 12.5–21.8), and the true seroprevalence was 16.1% (95% CI: 11.6–21.7), whereas in goats, the apparent seroprevalence was 2.4% (95% CI: 1.1–5.2), and the true seroprevalence was 0.7% (95% CI: −0.7 to 3.7). At the flock level, overall, apparent sheep and goat seroprevalence were 19.3% (95% CI: 11.1–31.3), 30.0% (95% CI: 16.1–49.8) and 7.4% (95% CI: 2.1–23.4) and true seroprevalence was 18.9% (95% CI: 10.1–31.9), 30.5% (95% CI: 16.1–49.8) and 6.1% (95% CI: 0.3–23.3) respectively. Univariable regression analysis revealed age as the only significant risk factor in the sampled population. Conclusions Brucella appears to be endemic to small ruminants in Qatar. The findings of this study provide baseline data regarding small ruminant brucellosis in Qatar and will aid in plans to control and eradicate the disease.
The Development of Population-Wide Descriptions of Human Rib and Rib Cage Geometry

The development of population-wide descriptions of human rib and rib cage geometry by Sven Alan Holcombe Co-Chairs: Professor James B. Grotberg, Professor Stewart C. Wang Elderly individuals, obese individuals, and females all have greater risk of rib fractures and other associated thoracic injuries than younger mid-sized male adults in motor vehicle crashes. Differences in body morphology between these vulnerable populations and the subjects represented by physical or computational human body models is a potential source for this risk disparity, and efforts are required to quantify these differences in order to protect a wider population. We present a novel parametric shape model of the human rib centroidal path using logarithmic spirals. It provides a more accurate and efficient fit than previous models of overall rib geometry, and it utilizes direct geometric properties such rib size, aspect ratio, and “skewness” in its parameterization. The model was fitted to 21,124 ribs from 1000 adult CT scans, and regression analyses produced a flexible rib shape model to build ribs typical for any population of a given age, height, weight, and sex. Significant differences in rib shape were quantified across populations, and a new aging effect was uncovered whereby rib span and rib aspect ratio are seen to increase with age, producing characteristically shallower and flatter overall
ETHYLENE RESPONSE FACTOR 070 inhibits flowering in Pak-choi by indirectly impairing BcLEAFY expression.

APETALA2/ethylene-responsive factors respond to ethylene and participate in many biological and physiological processes, such as plant morphogenesis, stress resistance, and hormone signal transduction. Ethylene responsive factor 070 （BcERF070）is important in flowering. However, the underlying molecular mechanisms of BcERF070 in floral transition in response to ethylene signaling have not been fully characterized. Herein, we explored the function of BcERF070 in Pak-choi [Brassica campestris (syn. Brassica rapa) ssp. chinensis]. Ethylene treatment induced BcERF070 expression and delayed flowering in Pak-choi. Silencing of BcERF070 induced flowering in Pak-choi. BcERF070 interacted with major latex protein-like 328 (BcMLP328), which forms a complex with helix-loop-helix protein 30 (BcbHLH30) to enhance the transcriptional activity of BcbHLH30 on LEAFY (BcLFY), ultimately promoting flowering. However, BcERF070 impaired the BcMLP328-BcbHLH30 complex activation of LEAFY (BcLFY), ultimately inhibiting flowering in Pak-choi. BcERF070 directly promoted the expression of the flowering inhibitor gene B-box 29 (BcBBX29) and delayed flowering by reducing FLOWERING LOCUS T (BcFT) expression. These results suggest that BcERF070 mediates ethylene-reduced flowering by impairing the BcMLP328-BcbHLH30 complex activation of BcLFY and by directly promoting the gene expression of the flowering inhibition factor BcBBX29 to repress BcFT expression. The findings contribute to understanding the molecular mechanisms underlying floral transition in response to ethylene in plants.
Mesoproterozoic fluid events affecting Archean crust in the northern Olympic Cu–Au Province, Gawler Craton: insights from 40Ar/39Ar thermochronology

ABSTRACT The Olympic Cu–Au Province, Gawler Craton, is host to the Olympic Dam and Prominent Hill iron oxide–copper–gold (IOCG) deposits. Both of these deposits and the region between the two are covered by Neoproterozoic to Cenozoic sediment, making inferences about prospectivity in this portion of the Olympic Domain reliant on geophysical interpretation and sparse drill hole information. We present new U–Pb zircon sensitive high resolution ion microprobe (SHRIMP) dates from two basement intersecting drill holes in the region between Olympic Dam and Prominent Hill that show bimodal volcanism occurred at 2555 ± 5 Ma, and was followed by intrusion of tonalite at 2529 ± 6 Ma. Laser 40Ar/39Ar dating of biotite and muscovite from the tonalite yields ages around ca 2000 Ma, consistent with slow cooling trends observed in Archean rocks elsewhere in the northern Gawler Craton. Step heating experiments on K-feldspar from the same tonalite yields an age spectrum with older ages around 1740 Ma from the highest temperature steps becoming progressively younger to a minimum of 1565 Ma in the lowest temperature heating steps; this is consistent with either Paleoproterozic cooling to final closure of K-feldspar by 1565 Ma or a reheating event at ca 1565 Ma, with the latter more likely, given the evidence for sub-solidus alteration of the K-feldspar. Sericite within hematite–sericite–chlorite altered portions of the tonalite yield a poorly defined age of ca 1.6 Ga. Taken together the 40Ar/39Ar data providing evidence for a fluid event affecting this region between Olympic Dam and Prominent Hill during the early Mesoproterozoic. Low temperature quartz–carbonate–adularia veins occur in <10 cm wide fractures within basalt in one drill hole in this region. Adularia from these veins yields 40Ar/39Ar ages that span from ca 1.3–1.1 Ga. This age range is interpreted to approximate either the timing of adularia formation during a hydrothermal event or the timing of resetting of the 40Ar/39Ar systematics within the adularia as a result of fluid flow in this sample. This is evidence for a mid-Mesoproterozoic fluid event in the Gawler Craton and necessitates a reconsideration of the long-term stability of the craton, as it appears to have been affected, at least locally, by fluid flow related to a much larger event within the Australian continent, the Musgrave Orogeny.
Development of a Simulator for the Intermediate Storage Hub Selection Modeling and Visualization of Carbon Dioxide Transport Using a Pipeline

이산화탄소 포집 및 저장 / 격리 (CCS) 기술은 많은 이산화탄소 저감 방법 중 이상적인 방법으로 주목받고 있다. 이산화탄소를 포집해서 파이프라인을 통해 저장소까지 수송할 때, 저장소가 가까운 경우 직접 수송할 수도 있지만, 중간 저장의 역할을 하는 허브를 거쳐 수송할 수도 있다. 허브의 수와 위치를 결정하는 것은 중요한 문제이다. 다목적 의사 결정을 위한 수학 모델은 많은 제약식과 목적식을 수반하는데, 문제의 계산 복잡도가 증가하지만 항상 최적을 보장하지 않는다. 본 연구에서는, 이산화탄소 수송망에서 중간 저장 허브의 위치와 수를 결정하는 알고리즘을 제안하고, 이를 활용하여 이산화탄소 발생지의 연결 네트워크 시뮬레이터를 개발한다. 시뮬레이터에서는 또한 이산화탄소의 수송 경로를 제공한다. 사례 연구로 한국에 모델을 적용한다.
Chlokamycin, a New Chloride from the Marine-derived Streptomyces sp. MA2-12

A new chlorinated metabolite designated chlokamycin (1), was isolated along with ikarugamycin (2) from the culture broth of the marine-derived Streptomyces sp. MA2–12. The structure of 1 was elucidated based on spectroscopic analyses (1D and 2D NMR data and ROESY correlations). Chlokamycin moderately inhibited the growth of Jurkat cells and HCT116 cells with IC50 values of 24.7 and 33.5 μM, respectively.