Miracle-dz/UniFAR-FTUs huggingface dataset:
Short-Term Outcomes for Opiate and Crack Users Accessing Treatment: The Effects of Criminal Justice Referral and Crack Use

Background/Aims: The English drug treatment population doubled in size between 1998 and 2008, increasingly characterised by crack cocaine use and criminal justice system (CJS) referral. We assessed short-term (median 3.5 month) behaviour changes following participation in drug treatment and the moderating effect of CJS referral/crack use. Methods: Opiate and/or crack cocaine users (n = 1,267) were recruited from 342 agencies. Outcome effects were assessed via interaction term regression, clustered at participant level, controlling for client characteristics. Treatment retention effects were tested via Cox proportional hazard models. Results: Statistically significant improvements in health, drug use and offensive behaviour were observed (e.g. heroin use from 87 to 51%, acquisitive offending from 47 to 23%). Referral route was not associated with variation in outcomes. Crack use at baseline was associated with a greater chance of non-fatal overdose at follow-up (p = 0.035, 95% CI 1.08-8.20) but a greater reduction in offending income (p = 0.002, 95% CI £104-£419). Conclusion: Despite changes in the English drug treatment population, equivalent short-term improvements in client behaviour were observed a decade earlier. Outcomes for CJS-referred clients were comparable to non-CJS. Crack use at treatment entry offered some scope for greater improvements in offending but may be a barrier to cessation of mortality-associated risky behaviour.
How to Cluster Evolving Graphs ( Extended Abstract ) ?

Clustering is a frequently used tool in the analysis and evaluation of large and complex networks. Most such networks result from or model dynamic processes, thus clustering techniques need to be adapted. We provide a model for clustering graphs that are subject to changes. More precisely, we address the update problem, i. e. , maintaining the clustering while nodes and edges can be inserted and deleted, as well as the issue of clustering graph sequences. Furthermore, we give some illustrating examples and point out several pitfalls. This work is a first step towards a sound foundation for clustering on evolving graphs.
Occurrence of cardiac arrhythmias in Standardbred racehorses.

REASONS FOR PERFORMING STUDY Cardiac arrhythmias are a recognised but poorly characterised problem in the Standardbred racehorse. Frequency data could aid the development of cardiac arrhythmia screening programmes. OBJECTIVES To characterise the occurrence of cardiac arrhythmias in Standardbreds prior to racing and in the late post race period using a handheld, noncontinuous recording device. STUDY DESIGN Prospective, observational study, convenience sampling. METHODS Noncontinuous electrocardiographic recordings were obtained over a 12 week period from Standardbred horses competing at a single racetrack. Electrocardiograms were obtained before racing and between 6 and 29 min after the race using a handheld recording device. Prevalence of arrhythmias was calculated for all horses and overall frequency of arrhythmias was calculated for race starts and poor performers. Univariate logistic regression analysis was used to identify risk factors for cardiac arrhythmias. RESULTS A total of 8657 electrocardiogram recordings were obtained from 1816 horses. Six horses had atrial fibrillation after racing (prevalence = 0.11%, frequency = 0.14%), one horse had supraventricular tachycardia before racing (prevalence = 0.06%, frequency = 0.02%), and 2 horses had ventricular tachyarrhythmias after racing (prevalence = 0.06%, frequency = 0.05%). The frequency of atrial fibrillation among race starts with poor performance was 1.3-2.0%. Increasing age was a significant risk factor for the presence of atrial premature contractions before racing and atrial fibrillation and ventricular ectopy after racing. CONCLUSIONS Both physiological and pathological cardiac arrhythmias can be detected in apparently healthy Standardbred horses in the prerace and late post race period using noncontinuous recording methods. Future studies should examine cumulative training or racing hours as a risk factor for cardiac arrhythmia. The prevalence and frequency information may be useful for track veterinarians and regulatory personnel following trends in cardiac arrhythmias.
Parallel programming on a high‐performance application‐runtime

High‐performance application development remains challenging, particularly for scientists making the transition to a heterogeneous grid environment. In general areas of computing, virtual environments such as Java and . Net have proved to be successful in fostering application development, allowing users to target and compile to a single environment, rather than a range of platforms, instruction sets and libraries. However, existing runtime environments are focused on business and desktop computing and they do not support the necessary high‐performance computing (HPC) abstractions required by e‐Scientists. Our work is focused on developing an application‐runtime that can support these services natively. The result is a new approach to the development of an application‐runtime for HPC: the Motor system has been developed by integrating a high‐performance communication library directly within a virtual machine. The Motor message passing library is integrated alongside and in cooperation with other runtime libraries and services while retaining a strong message passing performance. As a result, the application developer is provided with a common environment for HPC application development. This environment supports both procedural languages, such as C, and modern object‐oriented languages, such as C#. This paper describes the unique Motor architecture, presents its implementation and demonstrates its performance and use. Copyright © 2008 John Wiley & Sons, Ltd.
Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway

Abstract Purpose To investigate the biological effects of a 50-Hz magnetic field (MF) on mitochondrial permeability. Materials and methods Human amniotic epithelial cells were exposed to MF (50 Hz, 0.4 mT) for different durations. Mitochondrial permeability, mitochondrial membrane potential (ΔΨm), cytochrome c (Cyt-c) release and the related mechanisms were explored. Results Exposure to the MF at 0.4 mT for 60 min transiently induced mitochondrial permeability transition (MPT) and Cyt-c release, although there was no significant effect on mitochondrial membrane potential (ΔΨm). Other than decreasing the total Bcl-2 associated X protein (Bax) level, MF exposure did not significantly affect the levels of Bax and B-cell lymphoma-2 (Bcl-2) in mitochondria. In addition, cells exposed to the MF showed increased intracellular reactive oxidative species (ROS) levels and glycogen synthase kinase-3β (GSK-3β) dephosphorylation at 9 serine residue (Ser9). Moreover, the MF-induced MPT was attenuated by ROS scavenger (N-acetyl-L-cysteine, NAC) or GSK-3β inhibitor, and NAC pretreatment prevented GSK-3β dephosphorylation (Ser9) caused by MF exposure. Conclusion MPT induced by MF exposure was mediated through the ROS/GSK-3β signaling pathway.
The FAB: A frontal assessment battery at bedside

To the Editor: I read with interest the article by Dubois et al.1 describing the Frontal Assessment Battery (FAB). Frontal systems impairment, and the resultant loss of executive control function, has been a neglected aspect of clinical dementia research.2 The FAB joins a very small cadre of “bedside” measures. However, it may be misleading to suggest that the Executive Interview (EXIT25) is sensitive to nonexecutive domains …
Face age estimation using wrinkle patterns

Face age estimation is a challenging problem due to the variation of craniofacial growth, skin texture, gender and race. With recent growth in face age estimation research, wrinkles received attention from a number of research, as it is generally perceived as aging feature and soft biometric for person identification. In a face image, wrinkle is a discontinuous and arbitrary line pattern that varies in different face regions and subjects. Existing wrinkle detection algorithms and wrinkle-based features are not robust for face age estimation. They are either weakly represented or not validated against the ground truth. The primary aim of this thesis is to develop a robust wrinkle detection method and construct novel wrinkle-based methods for face age estimation. First, Hybrid Hessian Filter (HHF) is proposed to segment the wrinkles using the directional gradient and a ridge-valley Gaussian kernel. Second, Hessian Line Tracking (HLT) is proposed for wrinkle detection by exploring the wrinkle connectivity of surrounding pixels using a cross-sectional profile. Experimental results showed that HLT outperforms other wrinkle detection algorithms with an accuracy of 84% and 79% on the datasets of FORERUS and FORERET while HHF achieves 77% and 49%, respectively. Third, Multi-scale Wrinkle Patterns (MWP) is proposed as a novel feature representation for face age estimation using the wrinkle location, intensity and density. Fourth, Hybrid Aging Patterns (HAP) is proposed as a hybrid pattern for face age estimation using Facial Appearance Model (FAM) and MWP. Fifth, Multi-layer Age Regression (MAR) is proposed as a hierarchical model in complementary of FAM and MWP for face age estimation. For performance assessment of age estimation, four datasets namely FGNET, MORPH, FERET and PAL with different age ranges and sample sizes are used as benchmarks. Results showed that MAR achieves the lowest Mean Absolute Error (MAE) of 3.00 ( 4.14) on FERET and HAP scores a comparable MAE of 3.02 ( 2.92) as state of the art. In conclusion, wrinkles are important features and the uniqueness of this pattern should be considered in developing a robust model for face age estimation.
A class of Sudan-decodable codes

In this paper Sudan's algorithm is modified into an efficient method to list-decode a class of codes which can be seen as a generalization of Reed-Solomon codes. The algorithm is specialized into a very efficient method for unique decoding. The code construction can be generalized based on algebraic-geometry codes and the decoding algorithms are generalized accordingly. Comparisons with Reed-Solomon and Hermitian codes are made.
Semantic representation of annotation involving texts and linked data resources

The explosive growth in web documents presents a rich opportunity to use this information to support knowledge discovery, by synthesizing and reasoning over statements and relationships expressed in those documents. However, the use of natural language in these documents means that the information cannot be directly used for computational analysis; it must be transformed into a computable representation. Natural Language Processing systems are being developed to perform this transformation, and the results of their processing can be stored and made available for knowledge discovery applications via structured annotations over documents. In this work, we sought to examine models to capture text-mined annotations. We first examine the utility of existing community-based models for representing annotations, primarily that of the Open Annotation Data Model (OA) and the NLP interchange format (NIF). We then propose a new model consisting of named graphs that separate annotations from resource descriptions. Our work overcomes limitations of existing models, provides interoperability between OA and NIF, and can be deployed to describe any kind of text annotation.
Prevalence and control of hypertension in a Niger Delta semi urban community, Nigeria

Background Hypertension is a public health problem worldwide, but the prevalence in Amassoma, Southern Ijaw Local Government Area is not known. Objective To investigate the prevalence of hypertension in the locality and the extent of control in diagnosed cases. Methods It is a prospective study involving interviewing. Four hundred adults aged 20 years and above selected through stratified random sampling across the various compounds called “AMA”; a unit of settlement comprising extended families of common ancestors. A self-developed, validated and pretested interviewer-administered questionnaire on demographics, predisposing factors, and medication history was used. In addition, measurement of respondents’ blood pressure, weight and height was carried out. The Body Mass Index calculated and the data were appropriately analysed. Results The response rate of questionnaire distribution was 100.0% being interviewer administered alongside weight, height and blood pressure measurement. Majority of respondents were female. Almost half of respondents (46.5%) had their BMI above normal, 15.3% (61) of which falls within the obese region (>30.0kg/m2). The mean (SD) systolic blood pressure among males was 133.3 (3.2) mmHg and that of females was 127.4 (3.0) while the mean (SD) diastolic blood pressures were 86.2 (1.7) and 83.9 (2.4) for males and females respectively. Crude prevalence rate of hypertension in the community was 15.0% (60) out of which 13.8 % (55) were previously diagnosed. The hypertension was that of Stage I in 11.5% (46) and Stage II in 3.5% (14). Hypertension prevalence was slightly higher in males (18.8%) than that of the females (12.5%) (p= 0.0889), Relative Risk (RR)=1.500 [95%CI 0.9422:2.388]. The prevalence rate among 40 years and above was 41.6% (42/101) who also constituted 70.0% (42/60) of participants with hypertension in the survey and 10.5% (42/400) of the total. Of the previously diagnosed cases of hypertension, only 31% (17/55) were taking their drugs during the survey and only 12.7% (07/55) had regular adherence to medication and adequate BP control was achieved in 7.3% (04/55). Majority of the patients on drugs (21.8%) (12/55) were either taking methydopa as monotherapy or in combination with amiloride and hydrochlorothiazide. Other drugs being taken by patients include lisinopril, propranolol, amlodipine, atenolol, nifedipine and low dose aspirin. Conclusions The prevalence of hypertension in the semi urban community is 15.0% with a pre-hypertension in another 23.5%. There was poor control of blood pressure among previously hypertensive patients.
Is the hair nicotine level a more accurate biomarker of environmental tobacco smoke exposure than urine cotinine?

Study objective: The aim of this study was to compare the two biomarkers of exposure to environmental tobacco smoke (ETS); urine cotinine and hair nicotine, using questionnaires as the standard. Design: A cross sectional study of children consecutively admitted to hospital for lower respiratory illnesses during the period of the study. Settings: Three regional hospitals in the larger Wellington area, New Zealand. Participants: Children aged 3–27 months and admitted to the above hospitals during August 1997 to October 1998. A total of 322 children provided 297 hair samples and 158 urine samples. Main results: Hair nicotine levels were better able to discriminate the groups of children according to their household's smoking habits at home (no smokers, smoke only outside the home, smoke inside the house) than urine cotinine (Kruskall-Wallis; χ2=142.14, and χ2=49.5, respectively (p<0.0001)). Furthermore, hair nicotine levels were more strongly correlated with number of smokers in the house, and the number of cigarettes smoked by parents and other members of the child's households. Hair nicotine was better related to the questionnaire variables of smoking in a multivariate regression model (r2=0.55) than urine cotinine (r2=0.31). Conclusions: In this group of young children, hair nicotine was a more precise biomarker of exposure to ETS than urine cotinine levels, using questionnaire reports as the reference. Both biomarkers indicate that smoking outside the house limits ETS exposure of children but does not eliminate it.
Pretreatment quality of life as a predictor of distant metastasis and survival for patients with nasopharyngeal carcinoma.

PURPOSE The purpose of this study was to examine the prognostic value of pretreatment quality of life (QoL) data on locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS A total of 347 new patients with NPC, who were curatively treated by conformal radiotherapy from March 2003 to December 2007, were recruited. The Taiwan Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 was completed before treatment. Multivariate Cox's proportional hazards models were used to analyze the impact of clinical and QoL variables on the treatment results. RESULTS The 5-year LRC, DMFS, and OS rates were 72.9%, 79.1%, and 68.4%, respectively. After adjusting the clinical variables, 10 QoL variables were observed to be significantly (P < .05) related to OS, and four QoL variables were related to DMFS. No QoL variable was predictive of LRC. Among the QoL variables that significantly predicted OS and DMFS, physical functioning was the most powerful predictor. A 10-point increase in the physical functioning score was associated with a 23% (95% CI, 12% to 34%) reduction in the likelihood of death and a 22% (95% CI, 9% to 36%) reduction in the likelihood of distant metastasis. CONCLUSION Our findings indicate that pretreatment QoL variables, especially physical functioning, provide easily available prognostic value for distant metastasis and survival in patients with NPC.
Life Course Pathways From Adverse Childhood Experiences to Adult Physical Health: A Structural Equation Model

Objective: This study examines pathways from adverse childhood experiences (ACEs) to physical health, directly and indirectly through lower income, health risk behaviors, social support, and adult adversity within a theoretical framework postulating stress proliferative and biological trajectories of cumulative adversity. Method: Data were obtained from 12,549 adult respondents of a state Behavioral Risk Factor Surveillance System survey. Multigroup structural equation modeling elucidated pathways differentiated by sex and age (older/younger than 45). Results: Good model fit was achieved in each test, indicating consistency with stress theorizing that ACEs significantly contribute to poorer physical health through direct and mediated paths. Younger adults evidenced direct ACE pathway to poor health suggesting early biological erosion, whereas paucity of social support among older adults was directly associated. Discussion: Findings indicate that stress process roles in eroding physical health and experience of wellness. Addressing early adversity is an important strategy toward reducing preventable health problems.
Psychosocial Determinants of Fruit and Vegetable Consumption in a Japanese Population

There is limited evidence in Japan regarding the psychosocial determinants of fruit/vegetable intake. We performed a cross-sectional study of people aged 18 years or older in four regions of Japan; 2308 (men: 1012, women: 1296) individuals who completed the questionnaires were included. We found that 24.8% of people were aware of the current recommendations for vegetables and 13.2% for fruit and that “ability to design meals” and “availability when eating outside of the home” were the most important factors related to self-efficacy and barriers to fruit and vegetable intake, respectively. People with high self-efficacy (OR: 3.16; 95% CI: 2.17, 4.60 for fruit; OR: 4.52; 95% CI: 3.08, 6.64 for vegetables) were more likely to consume more fruit and vegetables. People with high scores on attitude (OR: 1.54; 95% CI: 1.06, 2.24) and social support (OR: 1.59; 95% CI: 1.11, 2.27) were more likely to consume more fruit. People with high perceived barriers (OR: 0.69; 95% CI: 0.48, 0.98) were less likely to consume fruit. This study suggests a need to increase the general population’s awareness of the fruit and vegetable intake recommendations; facilitating positive attitudes, self-efficacy, and social support for individuals and strengthening the ability of individuals to design meals with more vegetables and fruit might be useful intervention programs.
Ca2+/Calmodulin-Dependent Protein Kinase II&dgr; and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure

Cardiac hypertrophy and heart failure (HF) are associated with reactivation of fetal cardiac genes, and class II histone deacetylases (HDACs) (eg, HDAC5) have been strongly implicated in this process. We have shown previously that inositol trisphosphate, Ca2+/calmodulin-dependent protein kinase II (CaMKII), and protein kinase (PK)D are involved in HDAC5 phosphorylation and nuclear export in normal adult ventricular myocytes and also that CaMKII&dgr; and inositol trisphosphate receptors are upregulated in HF. Here we tested whether, in our rabbit HF model, nucleocytoplasmic shuttling of HDAC5 was altered either at baseline or in response to endothelin-1, which would indicate HDAC5 phosphorylation and transcription effects. The fusion protein HDAC5–green fluorescent protein (HDAC5-GFP) was more cytosolic in HF myocytes (Fnuc/Fcyto 3.3±0.3 vs 7.2±0.4 in control), and HDAC5 was more phosphorylated. Despite this baseline cytosolic HDAC5 shift, endothelin-1 produced more rapid HDAC5-GFP nuclear export in HF versus control myocytes. We also find that PKD and CaMKII&dgr;C expression and activation state are increased in both rabbit and human HF. Inhibition of either CaMKII or PKD in HF myocytes partially restored the HDAC5-GFP Fnuc/Fcyto toward control, and simultaneous inhibition restored Fnuc/Fcyto to that in control myocytes. Moreover, adenovirus-mediated overexpression of PKD, CaMKII&dgr;B, or CaMKII&dgr;C reduced baseline HDAC5 Fnuc/Fcyto in control myocytes (3.4±0.5, 3.8±0.5, and 5.2±0.5, respectively), approaching that seen in HF. We conclude that chronic upregulation and activation of inositol trisphosphate receptors, CaMKII, and PKD in HF shifts HDAC5 out of the nucleus, derepressing transcription of hypertrophic genes. This may directly contribute to the development and/or maintenance of HF.
MARINE: THE ULTIMATE SOURCE OF BIOACTIVES AND DRUG METABOLITES

Bioactive compounds from marine flora and fauna have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Several molecules isolated from various marine organisms (microorganisms, algae, fungi, invertebrates, and vertebrates) are currently under study at an advanced stage of clinical trials, some of them have already been marketed as drugs. This article gives an overview of current trends in screening and the activity analysis of metabolites from marine resources. Although the marine resources have been somewhat limited to date, selected bioactive from marine flora and fauna have already published. This report summarizes the screening for bioactive compounds of marine animals and marine microorganisms. Finally, new approaches for the screening of metabolites from marine resources are discussed. The goal of this article is to expose the new models and mechanisms of action of marine substances to bring new solutions for tackling some of the major public health problems.