Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of lightning incidence on ships

In this paper calculations of lightning incidence on a bulk carrier ship model are presented with comparative application of various lightning attachment models and stroke current distributions. Depending on the ship structure, a lightning strike on coastal areas is expected approximately every two years. Regions exposed to lightning strikes were highlighted with application of the Rolling Sphere Method on the initial structure and after additional measures for the improvement of the external lightning protection system. Furthermore, impulse voltage experiments on a scaled down model of the above ship were conducted to assess the accuracy of lightning interception models. Lightning interception probability and proximity effects arise as factors that should be incorporated in shielding design.
Maximizing mutual information for multipass target search in changing environments

Motion planning for multi-target autonomous search requires efficiently gathering as much information over an area as possible with an imperfect sensor. In disaster scenarios and contested environments the spatial connectivity may unexpectedly change (due to aftershock, avalanche, flood, building collapse, adversary movements, etc.) and the flight envelope may evolve as a known function of time to ensure rescue worker safety or to facilitate other mission goals. Algorithms designed to handle both expected and unexpected changes must: (1) reason over a sufficiently long time horizon to respect expected changes, and (2) replan quickly in response to unexpected changes. These ambitions are hindered by the submodularity property of mutual information, which makes optimal solutions NP-hard to compute. We present an algorithm for autonomous search in changing environments that uses a variety of techniques to improve both the speed and time horizon, including using e-admissible heuristics to speed up the search.
Epigenetic regulation of cognition: A circumscribed review of the field

Abstract The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes.
Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster by an autogenous transcriptional attenuation mechanism

A complete transcript of the Bacillus subtilis pyr operon contains the following elements in 5' to 3' order: a 151-nucleotide (nt) untranslated leader; pyrR, encoding a 20-kDa protein; a 173-nt intercistronic region; pyrP, encoding a 46-kDa protein; a 145-nt intercistronic region; and eight overlapping cistrons encoding all of the six enzymes for de novo pyrimidine biosynthesis. Transcription is controlled by the availability of pyrimidines via an attenuation mechanism. There are three transcription terminators within the operon, each of which is preceded by another stem-loop structure, the antiterminator, whose formation would prevent formation of the terminator stem-loop. These are located in the leader, the pyrR-pyrP intercistronic region, and the pyrP-pyrB intercistronic region. Northern (RNA) blot analysis has identified transcripts of lengths which coincide with termination at these proposed attenuation sites and whose relative abundances vary in the expected pyrimidine-dependent manner. Each antiterminator contains a 50-base conserved sequence in its promoter-proximal half. Various transcriptional fusions of the pyr promoter and surrounding sequences to promoterless reporter genes support an attenuation mechanism whereby when pyrimidines are abundant, the PyrR protein binds to the conserved sequence in the pyr mRNA and disrupts the antiterminator, permitting terminator hairpin formation and promoting transcription termination. Deletion of pyrR from the chromosome resulted in the constitutive, elevated expression of aspartate transcarbamylase, which is encoded by pyrB, the third gene in the operon. Complementation of an E. coli upp mutant, as well as direct enzymatic assay, has demonstrated that pyrR also confers uracil phosphoribosyltransferase activity. Analysis of pyrR and upp deletion mutants demonstrated that upp, not pyrR, encodes the quantitatively important uracil phosphoribosyltransferase activity. The pyrP gene probably encodes an integral membrane uracil permease.
Analysis of Selected Kinematic and Physiological Performance Determinants During Incremental Testing in Elite Swimmers

This study examined the relationships between selected kinematic and physiological parameters and their influence on performance during incremental exercise in elite swimmers competing at the international level. Eleven men and ten women (all specialized in 200-m events) performed an incremental 7 × 200-m test in their specialized stroke. Stroke rate (SR), stroke length (SL), velocity (V), and blood lactate concentration (BLa) were measured for each 200 m. In addition to the cross-sectional group design, the longitudinal performance of a male swimmer was evaluated by 4 tests during a period of 20 weeks. Stroke rate increased and SL decreased with V, regardless of the age, stroke, or gender of the swimmer. Statistically significant correlations were found between SR and V (p < 0.01; r = 0.66 to 0.99), SR and SL (p < 0.01; r = −0.78 to -0.99), SL and V (except for women's freestyle and breaststroke) (p < 0.01; r = −0.67 to -0.98), and BLa and V (p < 0.01; r = 0.7 to 0.96). Changes in SR and SL were not affected by changes in BLa. Similar velocities were produced with different combinations of SR and SL. The fastest times reached in the test were generally slower than expected, and the performance in the test was not associated with competition performance. The case study revealed similar results to those of the group. The test used in this study was informative with respect to identifying the most economical and effective stroke kinematics combination for slow to submaximal velocities. It is possible that the swimming speeds were not maximal in the final 200-m swim because of cumulative fatigue, which is a major limitation for assessing race pace. An additional test that produces velocities similar to those used in competitions would be more useful for the purpose of providing optimal kinematic information specific to racing speeds, which would facilitate performance improvement through regular monitoring in training.
Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects

BACKGROUND This study was designed to establish the number and area (as a percentage) of bronchial wall vessels in subjects with and without asthma, to obtain information on the morphology of the vessels, and to see whether changes differed in patients with mild, moderate, and severe asthma. METHODS Biopsy specimens were taken using a rigid bronchoscope from the carina of the middle lobe bronchus of 20 patients with allergic asthma and 20 non-asthmatic controls. Specimens were sectioned and stained with haematoxylin-eosin, Masson trichrome, PAS, alcian blue-PAS, and orcein. The vessels were counted and the vascular area was calculated as a percentage in the lamina propria, in blind conditions, on PAS stained sections in 50 microscopic fields (magnification ×1000, 0.02 mm2 per field). The vascular area was calculated using the points counting procedure (Chalkley point array). The vascular morphology, intravascular cells, and the perivascular area were also studied using a magnification up to ×1200. RESULTS Patients with asthma had more vessels (mean (SD) 226.70 (74.53)v 172.05 (30.58), p=0.0043) and a larger percentage vascular area (8.61 (2.38)% v6.81 (2.25)%, p=0.028) than non-asthmatic subjects. Patients with severe asthma had significantly more vessels than those with mild or moderate disease (p=0.0044). Asthmatic capillaries and venules had oedematous walls and thickening of the subendothelial basement membrane, and hypotrophic or atrophic myocytes and fibrosis in the arterioles. Vessels from asthmatic subjects showed eosinophil recruitment, activation, and intravascular lysis. Intense eosinophil recruitment was associated with more marked vascular structural changes. Muscular formations protruded into the lumen in the arterioles of both groups, and in asthmatics these had hypotrophic or atrophic myocytes and fibrosis. CONCLUSIONS Morphometric analysis showed that the bronchial lamina propria of asthmatic subjects had a larger number of vessels, occupying a larger percentage area than in non-asthmatic subjects. The number of vessels was correlated with the severity of the asthma. Marked alterations to the vascular structure appeared to be associated with intense eosinophil recruitment and intravascular activation. This is the first report of asthmatic and non-asthmatic bronchial wall specimens containing intra-arteriolar muscular formations, presumably to regulate blood flow to the capillary network and/or sinusoids. This function might be impaired when these structures are remodelled in asthmatic patients.
Teetering near the edge; women's experiences of anal incontinence following obstetric anal sphincter injury: an interpretive phenomenological research study

Obstetric anal sphincter injury (OASIS) following vaginal delivery increases the risk of anal incontinence (AI). Subsequent vaginal delivery and ageing increase the risk of worsening symptoms. Very little literature describes any in‐depth understanding of what it is like to live with AI following a history of known OASIS.
Basketball event recognition technique using Deterministic Finite Automata(DFA)

Recently, many researchers and sport managers are trying to analyse the movement of sports players by combining sports and ICT technology, and to change the contents of the game using these analysis results. In the case of basketball, leading companies such as STATS Sports are focusing on tracking the players and analysing the players' movements. However, the recording of sports events such as shoot, foul, and rebound resulting from the players' movements is made entirely by the manual work of the recorders. In this paper, we propose a technique to automatically extract events generated by players or judges in basketball games. Experiments have shown that it is possible to automatically extract events by tracking players and referees and analysing the predefined motion of players and referees.
System Innovation and the Transition to Sustainability

This book considers two main questions: how do system innovations or transitions come about and how can they be influenced by different actors, in particular by governments. The authors identify the theories which can be used to conceptualise the dynamics of system innovations and discuss the weaknesses in these theories. They also look at the lessons which can be learned from historical examples of transitions, and highlight the instruments and policy tools which can be used to stimulate future system innovations towards sustainability. The expert contributors address these questions using insights from a variety of different disciplines including innovation studies, evolutionary economics, the sociology of technology, environmental analysis and governance studies. The book concludes with an extensive summary of the results and practical suggestions for future research.
An MDP-based model for optimal relay selection in OFDMA cooperative networks

In this paper we present a joint resource allocation and optimal relay selection scheme that meets the data rate QoS requirement of traffic in OFDMA networks. The proposed scheme selects the relay that best utilizes the attainable data rate for all subcarriers, as opposed to existing works which are based on selecting the optimal relay independently per single subcarrier. The scheme is further designed as a finite horizon Markov Decision Process (MDP). Simulation results show that the proposed scheme outperforms representative existing schemes in terms of the network total throughput and end-to-end outage probability.
Terahertz Radiation Modulated by Confinement of Picosecond Current Based on Patterned Ferromagnetic Heterostructures

The ultrashort laser excitation of nonmagnetic/ferromagnetic/nonmagnetic (NM/FM/NM) heterostructures is intensively studied as a terahertz (THz) emitter. Herein, the combined spintronic and photonic ultrathin metal heterostructures are exploited to realize actively modulated THz radiation. It is demonstrated that the THz radiation can be mediated coherently through the charge current induced by the inverse spin Hall effect (ISHE) and the built‐in transient current quasi‐simultaneously created within the striped NM/FM/NM heterostructures. The waveforms of THz radiation can be shaped by the charge current confinement effect, including the amplitude modulation and the center‐frequency shift. These findings can be utilized for device‐oriented opto‐spintronics and also extend the established THz emitter to THz modulator.
Development of androgenetic mouse embryos produced by in vitro fertilization of enucleated oocytes

Enucleated mouse oocytes were successfully fertilized in vitro, and the resultant androgenetic eggs developed to the blastocyst stage. The proportion of enucleated oocytes fertilized in vitro was high (87–99%) at sperm concentrations ranging from 10–100 × 104/ml. At high sperm concentrations (100–1,000 × 104), 35–45% of the fertilized eggs resulted in heterozygous bispermic androgenones. The proportion of hemizygous haploid and heterozygous diploid androgenones developing to blastocysts was 11% and 43%, respectively. Hemizygous diploidization, however, showed no positive effect on development. These results clearly show that the procedure reported here is efficient and reliable for the production of androgenetic eggs. © 1993 Wiley‐Liss, Inc.
Changes in tissue calcium and phosphorus content and plasma concentrations of parathyroid hormone and calcitonin after long-term magnesium deficiency in rats.

OBJECTIVE The present study was undertaken to investigate the effect of dietary magnesium (Mg) deficiency on plasma levels of parathyroid hormone (PTH) and calcitonin (CT), and the changes in tissue calcium (Ca) and phosphorus (P) content. METHODS Wistar rats were fed an Mg-deficient diet. Plasma levels of PTH and CT, and Ca and P content in plasma, whole blood, skeletal muscle, heart, kidney, femoral bone and brain, were determined after 7, 35, 42, 49, 56, 63 and 70 days. RESULTS Mg deficiency significantly increased plasma levels of ionic Ca after 1 week of deficiency, and significantly increased total Ca in plasma and whole blood after 5 weeks. Whole blood and plasma levels of P decreased significantly after 8 and 5 weeks, respectively, in comparison with values obtained in pair-fed control rats. Plasma levels of CT were not modified by hypercalcemia and hypomagnesemia. Plasma PTH decreased significantly during the first 3 weeks, then recovered gradually, reaching control values in week 7 and remaining stable thereafter, despite elevated levels of ionic Ca. The Mg-deficient diet led to calcification in skeletal muscle, heart, kidney and femur, detectable as early as week 5. However, P content increased only in kidney after 1 week, decreased in heart and femur after 5 weeks, and did not change in muscle. The Mg-deficient diet did not significantly modify Ca or P content in brain. CONCLUSION Mg deficiency led to tissue calcification and decreased P levels in blood, heart, and femur. These changes did not affect CT secretion. PTH appeared to be more closely related with hypomagnesemia than with hypercalcemia.
Metabolic effects of low aflatoxin B1 levels on broiler chicks

The effects of daily ingestion of aflatoxin B1 (AFB1) on growth, feed intake, plasma glucose, plasma cholesterol, plasma amino acids, plasma albumin, plasma ceruloplasmin, muscle amino acids, liver lipid, and bone strength were studied. For 3 weeks, beginning at an age of 2 days, broiler chicks were dosed daily per os with 50 or 100 micrograms of AFB1 per kg of body weight. Body weight and feed consumption were recorded daily, and metabolic responses were determined at 3 weeks. Treatment with AFB1 did not significantly alter body weight or feed intake. Relative liver weight showed a significant increase at the highest dose, with a significant concomitant increase in liver lipid and decrease in hepatic zinc. Relative spleen and heart weights were not affected by the toxin. Plasma glucose and cholesterol were significantly elevated at the highest dose. AFB1 significantly decreased plasma lysine and histidine and significantly increased muscle histidine, arginine, and valine. AFB1 decreased plasma albumin and markedly increased plasma ceruloplasmin. Dimensions of the long bones (femur and tibiotarsus) were not altered by the toxin. However, AFB1 caused a significant linear decline in the resistance of bone to breakage ("bone breaking strength"). The results indicate that low levels of AFB1 reduced bone strength in broiler chicks. The alterations in blood parameters indicated that AFB1 can disrupt metabolism even at low levels.
Viruses, chemotherapy and immunity

An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate that for many antiviral agents the response to therapy is highly dependent on the integrity of the underlying host immune response. In particular, the response to zidovudine, acyclovir and ganciclovir in persons with HIV-1 infection is highly dependent upon CD4 number, which can be considered a surrogate marker for the state of host immune function in these subjects. Responses to interferons likewise can be shown to depend on the host immune response, with responses due to both direct antiviral effects of this agent as well as immunomodulatory effects mediated through interferon-induced upregulation of HLA molecule expression.
Toll‐like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection

Hepatitis C virus (HCV) infection affects an estimated 3% of the world's population. The natural outcome of infection and the natural course of disease are highly variable. Sensing of viral single‐stranded RNA (ssRNA) by Toll‐like receptor 7 (TLR7) is likely involved in early pathogen detection and host response to viral infections. This study analyzed epidemiological and clinical data from 136 patients with HCV infection with regard to rs179008/Gln11Leu, a non‐synonymous polymorphism within exon 3 of the X‐linked TLR7 gene, the variant allele of which is suggested to code for a functionally impaired protein. Allele‐specific transcript quantification (ASTQ) analyses in heterozygous females revealed individual skewed mosaicism in peripheral blood mononuclear cells (PBMCs). Thus, analyses were restricted to homo‐ and hemizygous individuals. Among the clinical and histological parameters studied, the variant allele T was found to be solely associated with the presence of portal lymphoid aggregates. Whereas hepatic viral load and expression of genes known to be induced in chronic HCV infection were not found to differ in patients with wild‐type or variant TLR7 rs179008 genotype, significant lower gene expression of interleukin‐29 (IL‐29)/lambda1 interferon (IFN‐λ1) and both of its receptor subunits was found for T homo‐ and hemizygous patients. Irrespective of the minor differences in disease phenotype including hepatic viral load, natural, and alpha interferon (IFN‐α)‐mediated outcome of infection, and disease activity and progression, the significant differences in hepatic IL‐29/IFN‐λ1 and IFN‐λ receptor gene expression between TLR7 rs179008 T and A allele patients might have implications for responsiveness to future IFN‐λ‐based approaches. J. Med. Virol. 82:1859–1868, 2010. © 2010 Wiley‐Liss, Inc.
Protein Information and Knowledge Extractor: Discovering biological information from proteomics data

One of the main goals in proteomics is to solve biological and molecular questions regarding a set of identified proteins. In order to achieve this goal, one has to extract and collect the existing biological data from public repositories for every protein and afterward, analyze and organize the collected data. Due to the complexity of this task and the huge amount of data available, it is not possible to gather this information by hand, making it necessary to find automatic methods of data collection. Within a proteomic context, we have developed Protein Information and Knowledge Extractor (PIKE) which solves this problem by automatically accessing several public information systems and databases across the Internet. PIKE bioinformatics tool starts with a set of identified proteins, listed as the most common protein databases accession codes, and retrieves all relevant and updated information from the most relevant databases. Once the search is complete, PIKE summarizes the information for every single protein using several file formats that share and exchange the information with other software tools. It is our opinion that PIKE represents a great step forward for information procurement and drastically reduces manual database validation for large proteomic studies. It is available at http://proteo.cnb. csic.es/pike.
Comparison of the Fascia Iliaca Compartment Block with the 3‐in‐1 Block in Children

A new single injection procedure, the fascia iliaca compartment block, is described for blocking the femoral, lateral cutaneous, and obturator nerves. The technique consists of injecting a local anesthetic immediately behind the fascia iliaca at the union of the lateral with the two medial thirds of the inguinal ligament, and forcing it upward by finger compression. This block was prospectively evaluated in 60 pediatric patients aged 0.7 to 17 years undergoing surgery of the lower limb, and then compared with a similar group of 60 children given a 3-in-1 block. Adequate analgesia was only obtained in 20% of the patients given 3-in-1 blocks (group 1), whereas the fascia iliaca compartment block proved to be easy, free of complications, and effective in more than 90% of patients (group 2). Such a high failure rate in group 1 was not due to misplacement of the needle since a femoral nerve block developed in all patients. Therefore it is unlikely that the local anesthetic can spread rostrally towards the lumbar plexus then return peripherally along the issuing nerves, and this was, indeed, not confirmed by radiological findings. In the authors' opinion, a multieffective block can only develop when the local anesthetic is introduced behind the fascia iliaca, which circumscribes a potential space where the femoral, lateral cutaneous, and obturator nerves run for a considerable part of their course. This report shows that deliberately injecting this space almost always results in an easy and effective block of these three nerves. The fascia iliaca compartment block can be recommended for use in children.