Miracle-dz/UniFAR-FTUs huggingface dataset:
dbSCI: A manually curated database of SARS-CoV-2 inhibitors for COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of the ongoing coronavirus disease 2019 (COVID-19) global pandemic. Here, by centralizing published cell-based experiments, clinical trials, and virtual drug screening data from the NCBI PubMed database, we developed a database of SARS-CoV-2 inhibitors for COVID-19, dbSCI, which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments, 81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses. dbSCI provides four major functions: (1) search the drug target or its inhibitor for SARS-CoV-2, (2) browse target/inhibitor information collected from cell experiments, clinical trials, and virtual drug screenings, (3) download, and (4) submit data. Each entry in dbSCI contains 18 types of information, including inhibitor/drug name, targeting protein, mechanism of inhibition, experimental technique, experimental sample type, and reference information. In summary, dbSCI provides a relatively comprehensive, credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19. [ FROM AUTHOR]
Examining the Intention to Use Mobile Health Applications Amongst Indonesians

The use of m-health applications in Indonesia is currently increasing drastically during the COVID-19 pandemic. This has led to intense competition between companies providing health application services to continue to retain users, one of which is by understanding the important factors that influence the intention to use applications either directly or indirectly, apart from the COVID-19 pandemic. This study aims to examine the effect of quality application, perceived information quality, trust, perceived usefulness and intention to use. The data employed for this study were collected from 150 users of mobile health applications in Indonesia. Hypothesis testing in this study used the Structural Equation Modelling (SEM) for the statistical analysis method. The results of this study indicate that application quality has a positive effect on perceived information quality, perceived information quality has a positive effect on trust, trust has a positive effect on perceived usefulness, and perceived usefulness has a positive effect on intention to use. Finally, the managerial implications in this study are expected to be a source of thought, especially for companies in the health technology industry to continue to improve and evaluate the quality of application that indirectly affect intention to use.
A Search for H I 21 cm Absorption toward the Highest Redshift (z ∼ 5.2) Radio-loud Objects

We have searched for H I 21 cm absorption toward the two brightest radio AGNs at high redshift, J0924-2201 at z = 5.20 and J0913+5919 at z = 5.11, using the Giant Metrewave Radio Telescope. These data set a 3 σ upper limit to absorption of <30% at 40 km s-1 resolution for the 30 mJy source J0913+5919, and <3% for the 0.55 Jy source J0924-2201 at 20 km s-1 resolution. For J0924-2201, limits to broader lines at the few percent level are set by residual spectral baseline structure. For J0924-2201 the column density limit per 20 km s -1 channel is N(H ) < 2.2 × 1018Ts cm-2 over a velocity range of -700 to +1180 km s-1 centered on the galaxy redshift determined through CO emission, assuming a covering factor of 1. For J0913+5919 the column density limit per 40 km s-1 channel is N(H ) < 2.2 × 1019Ts cm-2 within ±2400 km s-1 of the optical redshift. These data rule out any cool, high column density H I clouds within roughly ±1000 km s-1 of the galaxies, as are often seen in compact steep-spectrum radio AGNs, or clouds that might correspond to residual gas left over from cosmic reionization.
The Structured Chromosphere and Wind of TW Hya

A continuous set of echelle spectra of TW Hya, taken with the MIKE spectrograph on the Magellan2/Clay telescope at Las Campanas Observatory in April 2006 reveals systematic variations in the flux, velocity, and profile of the H-alpha emission line which appear to be consistent with the photometric period of 2.8 days. Absorption features recur at high outflow velocities in the wind. This behavior suggests that: (a) accretion is not uniformly distributed over the stellar hemisphere in view; (b) stable structures are present in the chromosphere, most likely due to the stellar magnetic field configuration. Semi-empirical models of the atmosphere are constructed to reproduce line profiles of H-alpha and He I, 10830A and to define the wind structure. These preliminary calculations suggest the mass loss rate is variable and comparable to H-alpha mass accretion rates in the literature, requiring a very efficient mechanism if the wind is powered only by accretion.
Dark Energy Survey Year 1 results: the effect of intracluster light on photometric redshifts for weak gravitational lensing

We study the effect of diffuse intracluster light on the critical surface mass density estimated from photometric redshifts of lensing source galaxies, and the resulting bias in a weak lensing measurement of galaxy cluster mass. Under conservative assumptions, we find the bias to be negligible for imaging surveys like the Dark Energy Survey with a recommended scale cut of ≥200 kpc distance from cluster centres. For significantly deeper lensing source galaxy catalogues from present and future surveys like the Large Synoptic Survey Telescope program, more conservative scale and source magnitude cuts or a correction of the effect may be necessary to achieve percent level lensing measurement accuracy, especially at the massive end of the cluster population.
Development and evaluation of taste masked orally disintegrating tablets of pioglitazone hydrochloride

: Orally disintegrating tablets, over the years, have become the preferred alternative to conventional tablets and capsule dosage forms because of better compliance. These are suitable for special populations like pediatrics, geriatrics, patient with dysphagia, patients with hand tremors, patients with frequent traveling, etc. The focus of this research was to mask the unpleasant taste of type 2 antidiabetic drug “Pioglitazone Hydrochloride” followed by designing an orally disintegrating tablet of the same. Taste masking was accomplished using a pH-independent polymeric dispersion of ethylcellulose i.e. “Surelease E-7-19040” in combination with a Hypromellose-based ready-to-coat film coating system i.e. “Opadry YS-1-19025-A” in a different ratio. Uncoated powder, coated granules, and prepared tablets of Pioglitazone Hydrochloride were investigated for in-vivo taste evaluation and flow as well as compression behavior, Fourier Transform Infrared spectra, scanning electron microscopy, powder X-ray diffraction, and in-vitro dissolution, disintegration properties. The study demonstrated the use of 3 2 full factorial design study to identify optimal ratio of pore former in Surelease and Opadry polymeric coating combination to achieve desired taste masking of unpleasant Pioglitazone Hydrochloride without any impact on immediate release characterstic of the orally disintegtrating tablet formulation. It further demonstrated that, an increase in pore former concentration resulted in a lower rating by human volunteers indicating relatively more bitterness, however, an increase in percent weight gain resulted in a higher rating by human volunteers indicating efficient taste masking.
A Model for Clumpy Self-enrichment in Globular Clusters

Detailed observations of globular clusters (GCs) have revealed evidence of self-enrichment: some of the heavy elements that we see in stars today were produced by cluster stars themselves. Moreover, GCs have internal subpopulations with different elemental abundances, including, in some cases, in elements such as iron that are produced by supernovae. This paper presents a theoretical model for GC formation motivated by observations of Milky Way star-forming regions and simulations of star formation, where giant molecular clouds fragment into multiple clumps that undergo star formation at slightly different times. Core collapse supernovae from earlier-forming clumps can enrich later-forming clumps to the degree that the ejecta can be retained within the gravitational potential well, resulting in subpopulations with different total metallicities once the clumps merge to form the final cluster. The model matches the mass–metallicity relation seen in GC populations around massive elliptical galaxies, and predicts metallicity spreads within clusters in excellent agreement with those seen in Milky Way GCs, even for those whose internal abundance spreads are so large that their entire identity as a GC is in question. The internal metallicity spread serves as an excellent measurement of how much self-enrichment has occurred in a cluster, a result that is very robust to variation in the model parameters.
Molecular orientation in soft matter thin films studied by resonant soft x-ray reflectivity

We present a technique to study depth profiles of molecular orientation in soft matter thin films with nanometer resolution. The method is based on dichroism in resonant soft X-ray reflectivity using linear s- and p-polarization. It combines the chemical sensitivity of Near-Edge X-ray Absorption Fine Structure spectroscopy to specific molecular bonds and their orientation relative to the polarization of the incident beam with the precise depth profiling capability of X-ray reflectivity. We demonstrate these capabilities on side chain liquid crystalline polymer thin films with soft X-ray reflectivity data at the carbon K edge. Optical constants of the anisotropic refractive index ellipsoid were obtained from a quantitative analysis using the Berreman formalism. For films up to 50 nm thickness we find that the degree of orientation of the long axis exhibits no depth variation and isindependent of the film thickness.
The structure behind the Galactic bar traced by red clump stars in the VVV survey★

Red clump stars are commonly used to map the reddening and morphology of the inner regions of the Milky Way. We use the new photometric catalogues of the VISTA Variables in the V´ia La´ctea survey to achieve twice the spatial resolution of previous reddening maps for Galactic longitudes − 10◦ < l < 10◦ and latitudes −1.5◦ < b < 1.5◦. We use these de- reddened catalogues to construct the Ks luminosity function around the red clump in the Galactic plane. We show that the secondary peak (fainter than the red clump) detected in these regions does not correspond to the bulge red-giant branch bump alone, as previously interpreted. Instead, this fainter clump corresponds largely to the over-density of red clump stars tracing the spiral arm structure behind the Galactic bar. This result suggests that studies aiming to characterize the bulge red-giant branch bump should avoid low galactic latitudes (|b| < 2◦), where the background red clump population contributes significant contamination. It furthermore highlights the need to include this structural component in future modelling of the Galactic bar.
It Is Represented in the Media, So it Exists: Anxiety in the Movies ‘Eighth Grade’ and ‘Silver Linings Playbook’

This paper aims to understand how anxiety disorders are represented in the films Eighth Grade and Silver Linings Playbook. A filmic analysis is conducted, specifically narrative analysis. Additionally, qualitative interviews with qualified informants bring a more robust understanding of anxiety disorders and explanation of the results obtained. The results reveal that the filmmakers choose to represent characters with characteristics that go beyond mental illness, enabling an identification by the viewers. In Eighth Grade, there are characteristics coincident with the symptomatology, such as apathy, restlessness, and irritability, and deviant ones, such as dependence on the Internet, the manifestation of increased maturity, and the revealing of confidence. In Silver Linings Playbook, irritability, mood swings, and refuge in sports are coincident particularities, and the expression of happiness, motivation, and recognition of overcoming are dissonant symptomatology. In both films, there was an attempt by the filmmakers to convey a positive message and a happy ending, condensing the idea of overcoming mental illness. The films, assuming an educational function, provide tools that teach how to deal with anxiety in everyday life.
A Novel Immune-Related Gene Prognostic Index (IRGPI) in Pancreatic Adenocarcinoma (PAAD) and Its Implications in the Tumor Microenvironment

Simple Summary Pancreatic adenocarcinoma (PAAD) is one of the leading causes of cancer death across the world, with extremely poor clinical outcomes within 5 years. From that end, survival prediction for such patients is essential, while in-service biomarkers are in need to be improved. Therefore, in the present study, we developed a machine learning-based prognostic model for robust and accurate survival prediction for PAAD patients. Additionally, we explored its critical implications in the tumor immunological microenvironment, sharing new insights into new therapeutic strategies in the future. Abstract Purpose: Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies, with less than 10% of patients surviving more than 5 years. Existing biomarkers for reliable survival rate prediction need to be enhanced. As a result, the objective of this study was to create a novel immune-related gene prognostic index (IRGPI) for estimating overall survival (OS) and to analyze the molecular subtypes based on this index. Materials and procedures: RNA sequencing and clinical data were retrieved from publicly available sources and analyzed using several R software packages. A unique IRGPI and optimum risk model were developed using a machine learning algorithm. The prediction capability of our model was then compared to that of previously proposed models. A correlation study was also conducted between the immunological tumor microenvironment, risk groups, and IRGPI genes. Furthermore, we classified PAAD into different molecular subtypes based on the expression of IRGPI genes and investigated their features in tumor immunology using the K-means clustering technique. Results: A 12-gene IRGPI (FYN, MET, LRSAM1, PSPN, ERAP2, S100A1, IL20RB, MAP3K14, SEMA6C, PRKCG, CXCL11, and GH1) was established, and verified along with a risk model. OS prediction by our model outperformed previous gene signatures. According to the findings of our correlation studies, different risk groups and IRGPI genes were found to be tightly related to tumor microenvironments, and PAAD could be further subdivided into immunologically distinct molecular subtypes based on the expression of IRGPI genes. Conclusion: The current study constructed and verified a unique IRGPI. Furthermore, our findings revealed a connection between the IRGPI and the immunological microenvironment of tumors. PAAD was differentiated into several molecular subtypes that might react differently to immunotherapy. These findings could provide new insights for precision and translational medicine for more innovative immunotherapy strategies.
A high‐efficiency GaAlAs double‐heterostructure photovoltaic detector

An antireflection‐coated GaAlAs double‐heterostructure photovoltaic detector is described whose extrinsic power conversion efficiency is 56% when used with a focused 8075‐μm wavelength laser beam. This, to our knowledge, is the highest photovoltaic efficiency yet reported. A partially reflective rear contact provides extrinsic quantum efficiencies exceeding 0.90 with a relatively thin active region. By restricting the diameter of this contact to 50 μm and using high dopings to reduce series resistance, open‐circuit voltages of 1.15 V and fill factors up to 0.84 are obtained. The series resistance was 3.0 Ω, with 1.0 Ω being attributable to the contacts.
Structure and Dynamics of Candidate O Star Bubbles in N44

Dynamical studies of superbubbles and Wolf-Rayet ring nebulae show discrepancies from the standard adiabatic model for windblown bubbles. We therefore study the physical properties and kinematics of three candidate bubbles blown by single O stars to evaluate whether these discrepancies are also found in these simpler objects. Our sample candidates are N44 F, N44 J, and N44 M, in the outskirts of the H II complex N44 in the Large Magellanic Cloud. We have obtained ground-based and Hubble Space Telescope emission-line images and high-dispersion echelle spectra for these objects. From the Hα luminosities and the [O III]/Hα ratios of these nebulae, we estimate the spectral types of the ionizing stars to be O7 V, O9.5 V, and O9.5 V for N44 F, N44 J, and N44 M, respectively. We find that the observed expansion velocity of 12 km s-1 for N44 F is consistent with the stellar wind luminosity expected from the central ionizing star, as predicted by the standard bubble model. The observed upper limits for the expansion velocities of N44 J and N44 M are also compatible with the expected values, within the uncertainties. We also report the discovery in N44 F of strongly defined dust columns, similar to those seen in the Eagle Nebula. The photoevaporation of these dense dust features may be kinematically important and may actually govern the evolution of the shell. The inclusion of photoevaporation processes may thus undermine the apparent agreement between the observed bubble dynamics and the simple adiabatic models.
A scoping review protocol on diagnostic and treatment costs of cardiovascular disease management in India

Background: Cardiovascular disease (CVD) is a leading cause of mortality in India. Economic threats due to CVDs have surged, as diagnostic and treatment costs are out-of-pocket expenses. The increasing prevalence of CVDs in India is due to globalization, industrialization, aging, tobacco and alcohol consumption, diet, and sleep patterns. This scoping review provides a summary of the costs incurred in diagnosing and treating CVDs in India. Methods: The JBI updated methodology aligned with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) will guide this scoping review. Searches will be conducted on PubMed, Scopus, Cochrane Library, Embase, Econ Papers, and ProQuest databases. Google Scholar and Shodhganga will be used to search for relevant gray literature. Bibliographic mining will be performed to identify additional relevant studies. The literature published from 2000 onwards will be the primary focus. All direct and indirect costs for the diagnosis and treatment of CVDs across various levels of healthcare settings will be included. A two-stage independent screening, consisting of title and abstract screening, followed by full-text screening, will be conducted to identify eligible articles. Data will be extracted from full-text studies using a customized data extraction form. The results will be compiled and presented in the scoping review performed. Ethics and dissemination: A conference presentation and scientific peer-reviewed journal publication will be the sources for disseminating the review results. This study does not require an ethics review because publicly available sources were used to retrieve data.
The relation between transpolar potential and reconnection rates during sudden enhancement of solar wind dynamic pressure: OpenGGCM‐CTIM results

This study investigates how solar wind energy is deposited into the magnetosphere‐ionosphere system during sudden enhancements of solar wind dynamic pressure (Psw), using the coupled Open Geospace General Circulation Model–Coupled Ionosphere Thermosphere Model (OpenGGCM‐CTIM) 3‐D global magnetosphere‐ionosphere‐thermosphere model. We simulate three unique events of solar wind pressure enhancements that occurred during negative, near‐zero, and positive interplanetary magnetic field (IMF) Bz. Then, we examine the behavior of the dayside and nightside reconnection rates and quantify their respective contributions to cross polar cap potential (CPCP), a proxy of ionospheric plasma convection strength. The modeled CPCP increases after a Psw enhancement in all three cases, which agrees well with observations from the Defense Meteorological Satellite Program spacecraft and predictions from the assimilative mapping of ionospheric electrodynamics technique. In the OpenGGCM‐CTIM model, dayside reconnection increases within 9–13 min of the pressure impact, while nightside reconnection intensifies about 13–25 min after the pressure increase. As the strong Psw compresses the dayside magnetosheath and, subsequently, the magnetotail, their magnetic fields intensify and activate stronger antiparallel reconnection on the dayside magnetopause first and near the central plasma sheet second. For southward IMF, dayside reconnection contributes to the CPCP enhancement 2–4 times more than nightside reconnection. For northward IMF, the dayside contribution weakens, and nightside reconnection contributes more to the CPCP enhancement. We find that high‐latitude magnetopause reconnection during northward IMF produces sunward ionospheric plasma convection, which decreases the typical dawn‐to‐dusk ionosphere electric field. This results in a weaker dayside reconnection contribution to the CPCP during northward IMF.
The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury

Neuropathic pain is a pathological pain state with a broad symptom scope that affects patients after nerve injuries, but it can also arise after infections or exposure to toxic substances. Current treatment possibilities are still limited because of the low efficacy and severe adverse effects of available therapeutics, highlighting an emerging need for novel analgesics and for a detailed understanding of the pathophysiological alterations in the onset and maintenance of neuropathic pain. Here, we show that the novel and highly specific FKBP51 inhibitor SAFit2 restores lipid signaling and metabolism in nervous tissue after nerve injury. More specifically, we identify that SAFit2 restores the levels of the C16 dihydroceramide, which significantly reduces the sensitization of the pain-mediating TRPV1 channel and subsequently the secretion of the pro-inflammatory neuropeptide CGRP in primary sensory neurons. Furthermore, we show that the C16 dihydroceramide is capable of reducing acute thermal hypersensitivity in a capsaicin mouse model. In conclusion, we report for the first time the C16 dihydroceramide as a novel and crucial lipid mediator in the context of neuropathic pain as it has analgesic properties, contributing to the pain-relieving properties of SAFit2.
Team O2AC at the world robot summit 2020: towards jigless, high-precision assembly

High-mix, low-volume assembly has been a long-standing challenge for robot systems. We present a complete 2-armed robot system with general-purpose grippers and hand-held tools, which can perform assembly for a wide variety of objects with tight tolerances. The complete source code and 3D-printed-part designs are available for download and can be executed in simulation and with physical robots using a regular desktop computer. Furthermore, we present the designs of multiple tools which can be grasped and used by the robots in a human-like fashion. The system uses no parts-specific jigs and grippers to be applied to many different parts. It achieves high precision and reliability by using the environment and gripper surfaces to position the grasped objects. The system obtained 3rd place and the Japanese Society for Artificial Intelligence Award at the World Robot Summit 2020 Assembly Challenge. GRAPHICAL ABSTRACT