Miracle-dz/UniFAR-FTUs huggingface dataset:
Endothelial Cell Processing of von Willebrand Proteins a

The endothelial regulation of vWF synthesis, storage, regulated and constitutive release, and now binding are the focus of numerous research laboratories. The understanding of these phenomena is important to the pathophysiology of local hemostasis. Although the structural understanding of the relationship of vW AgII to vWF is now known, its functional role in synthesis, release, or function is yet to be clearly defined.
An Experiment Study on Text Transformation for Compression Using Stoplists and Frequent Words

The paper presents a new text transform algorithm suitable for embedding in compression algorithms. The strategy the new algorithm employed to increase performance of text compression is to replace words with predefined codes. Instead of using a huge dictionary containing exhaustive words as in previous works, the new algorithm uses a list of stoplists and/or frequent words. The research devised different encoding schemes for such a list. It then made experiments of using these schemes with different compression algorithms on standard texts. The result shows that each scheme gives increasing compression when using with specific compression algorithms.
Context and Trust Aware Workflow Oriented Access Framework

Service oriented computing (SoC) changes the way of conducting business as these services are often available on a network. As traditional access control approach may not work in the changed environment, protecting business resource from misuse is a big challenge. Again, static allocation of access right to users will not be an efficient solution as SoC environment changes with time. This paper focuses on design of dynamic access control approach for business process. Here, we propose a context and trust aware workflow oriented access framework. Proposed approach focuses on inter-component relationship where phases are executed either in online or offline mode to avoid performance bottleneck. The concept of static binding in role based access model is extended to support dynamic access control by including context awareness and trust relationship between owner and user. Trust is either directly or indirectly dependent on service level agreement (SLA) compliance, quality of service, reputation and provenance (historical data). In this paper, the framework is designed by mapping proposed access model to workflow instances at run-time. It is validated by workflow net model, where workflow instance can be successfully executed without any interruption and can satisfy soundness property while incorporating proposed access control approach.
From Toy Story to Toy History: a deep analysis of Debian GNU/Linux

The Debian operating system is one of the more popular GNU/Linux distributions today. From its birth, one decade ago, it has undergone many technical, structural and organizational changes. This article tries to study the evolution of Debian in the last five years, comparing the last the four stable versions of this distribution in size, programming languages and packages. Also the evolution of the number of voluntary developers (maintainers) in the Debian project is analyzed and an estimation of the effort is made in human and economic terms that would be necessary to produce a software of this size. The main evidences that we have found are that Debian approximately doubles to the size in lines of code and number of packages every two years, whereas the mean value of the packages’ sizes remain constant. A great majority of the packages of the first version considered in this study “have survived” in time and are present in more modern versions of Debian, many of them even with the same version number. The most widely used programming language is C, although its importance is decreasing with time. At last, the results of the evolution of Debian during these last five years are used to make a prediction of how the next stable version of Debian could be, when it cuold be shipped and what challenges (limiting factors) it will have to surpass.
Comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancer.

BACKGROUND Ovarian cancer is the fifth most common cause of cancer deaths in women in the United States. Numerous gene signatures of patient prognosis have been proposed, but diverse data and methods make these difficult to compare or use in a clinically meaningful way. We sought to identify successful published prognostic gene signatures through systematic validation using public data. METHODS A systematic review identified 14 prognostic models for late-stage ovarian cancer. For each, we evaluated its 1) reimplementation as described by the original study, 2) performance for prognosis of overall survival in independent data, and 3) performance compared with random gene signatures. We compared and ranked models by validation in 10 published datasets comprising 1251 primarily high-grade, late-stage serous ovarian cancer patients. All tests of statistical significance were two-sided. RESULTS Twelve published models had 95% confidence intervals of the C-index that did not include the null value of 0.5; eight outperformed 97.5% of signatures including the same number of randomly selected genes and trained on the same data. The four top-ranked models achieved overall validation C-indices of 0.56 to 0.60 and shared anticorrelation with expression of immune response pathways. Most models demonstrated lower accuracy in new datasets than in validation sets presented in their publication. CONCLUSIONS This analysis provides definitive support for a handful of prognostic models but also confirms that these require improvement to be of clinical value. This work addresses outstanding controversies in the ovarian cancer literature and provides a reproducible framework for meta-analytic evaluation of gene signatures.
Index Policies for Real-Time Multicast Scheduling for Wireless Broadcast Systems

Motivated by the increasing usage of wireless broadcast networks for multicast real-time applications like video, this paper considers a canonical real-time multicast scheduling problem for a wireless broadcast LAN. A wireless access point (AP) has N latency-sensitive flows, each associated with a deadline and a multicast group of receivers that desire to receive all the packets successfully by their corresponding deadlines. We consider periodic and one-shot models of real-time arrivals. The channel from the AP to each receiver is a wireless erasure channel, independent across users and slots. We wish to find a communication strategy that minimizes the total deadlines missed across all receivers, where a receiver counts a miss if it does not receive a packet by its deadline. We cast this problem as a restless bandit in stochastic control. We use Whittle's relaxation framework for restless bandits to establish Whittle-indexability for multicast realtime scheduling under the assumption of complete feedback from all receivers in every slot. For the Whittle relaxation, we show that for each flow, the AP's decision between transmitting in a slot and idling has a threshold structure. For the homogeneous case where the erasure channel to each receiver is identically distributed with parameter p, the Whittle index of a flow is xi(1 - p) , where xi is the number of receivers who have yet to receive the current packet of flow i. For the general heterogeneous case in which the erasure channel to receiver j has loss probability pj, the Whittle index corresponding to each flow is Sigmaj (1- pj), where the sum is over all multicast receivers who are yet to receive the packet. We bound the performance of the optimal Whittle relaxation with respect to the optimal wireless multicast real-time scheduler. The heuristic index policy that schedules the flow with the maximum Whittle index in each slot is simple. To relax the complete feedback assumption, we design a scalable mechanism based on statistical estimation theory that obtains the required feedback from all the receivers using a single ACK per packet transmission. The resultant policy is amenable to low-complexity implementation.
Repression of small toxic protein synthesis by the Sib and OhsC small RNAs

The sequences encoding the QUAD1 RNAs were initially identified as four repeats in Escherichia coli. These repeats, herein renamed SIB, are conserved in closely related bacteria, although the number of repeats varies. All five Sib RNAs in E. coli MG1655 are expressed, and no phenotype was observed for a five‐sib deletion strain. However, a phenotype reminiscent of plasmid addiction was observed for overexpression of the Sib RNAs, and further examination of the SIB repeat sequences revealed conserved open reading frames encoding highly hydrophobic 18‐ to 19‐amino‐acid proteins (Ibs) opposite each sib gene. The Ibs proteins were found to be toxic when overexpressed and this toxicity could be prevented by coexpression of the corresponding Sib RNA. Two other RNAs encoded divergently in the yfhL‐acpS intergenic region were similarly found to encode a small hydrophobic protein (ShoB) and an antisense RNA regulator (OhsC). Overexpression of both IbsC and ShoB led to immediate changes in membrane potential suggesting both proteins affect the cell envelope. Whole genome expression analysis showed that overexpression of IbsC and ShoB, as well as the small hydrophobic LdrD and TisB proteins, has both overlapping and unique consequences for the cell.
CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats

The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear. In this study, we explored the role of CXCL10 and the effect of CXCL10 neutralization in lipopolysaccharide (LPS)-induced ARDS in rats. The expression of CXCL10 and its receptor chemokine receptor 3(CXCR3) increased after LPS induction. Moreover, neutralization of CXCL10 ameliorated the severity of ARDS by reducing pulmonary edema, inhibiting the release of inflammatory mediators (IFN-γ, IL-6 and ICAM-1) and limiting inflammatory cells (neutrophils, macrophages, CD8+ T cells) influx into the lung, with a reduction in CXCR3 expression in neutrophils and macrophages. Therefore, CXCL10 could be a potential therapeutic target in LPS-induced ARDS.
Signal Detection Theory (SDT)

Signal Detection Theory (sdt) is used to analyze data coming from experiments where the task is to categorize ambiguous stimuli which can be generated either by a known process (called the signal) or be obtained by chance (called the noise in the sdt framework). In particular sdt is used to analyze experiments where a binary answer (e.g., “Yes” vs “No”) needs to be provided. For example, if we need to decide if an education program is effective or not, we can use sdt.
PATERNAL ADHD, PARENTING, AND CHILD CONDUCT PROBLEMS: POTENTIAL MECHANISMS.

Title of Dissertation: PATERNAL ADHD, PARENTING, AND CHILD CONDUCT PROBLEMS: POTENTIAL MECHANISMS. Abigail D. Mintz, Doctor of Philosophy, 2012 Dissertation Directed By: Professor Andrea Chronis-Tuscano Department of Psychology Parental factors, specifically psychopathology and parenting, robustly predict negative developmental outcomes among children with attentiondeficit/hyperactivity disorder (ADHD). Indeed, emergent findings have linked maternal ADHD symptoms both with sub-optimal parenting and child conduct problems within families of children with ADHD. Despite considerable research supporting the important and unique contributions of fathers to their children’s development, the role of fathers within families of children with ADHD has seldom been examined. In particular, little research has been conducted with regard to paternal ADHD symptoms and parenting, despite clear evidence for an association between maternal ADHD symptoms and maladaptive parenting. The current study examined psychopathology and parenting behavior among a sample of fathers (N=102) and their 5-12 year-old children with previously-diagnosed ADHD. Results indicated that paternal antisocial personality disorder (ASPD) symptoms (rather than ADHD symptoms) were robustly associated with child conduct problems, and paternal negative parenting mediated this relationship. Future research using prospective longitudinal designs should examine multiple forms of psychopathology and parenting behavior among fathers of children with ADHD in order to identify potential risk factors and associated mechanisms for the development of child conduct problems. PATERNAL ADHD, PARENTING, AND CHILD CONDUCT PROBLEMS: POTENTIAL MECHANISMS.
Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome

There is a need for biological markers of the acute respiratory distress syndrome (ARDS). Exhaled breath contains hundreds of metabolites in the gas phase, some of which reflect (patho)physiological processes. We aimed to determine the diagnostic accuracy of metabolites in exhaled breath as biomarkers of ARDS. Breath from ventilated intensive care unit patients (n=101) was analysed using gas chromatography and mass spectrometry during the first day of admission. ARDS was defined by the Berlin definition. Training and temporal validation cohorts were used. 23 patients in the training cohort (n=53) had ARDS. Three breath metabolites, octane, acetaldehyde and 3-methylheptane, could discriminate between ARDS and controls with an area under the receiver operating characteristic curve (AUC) of 0.80. Temporal external validation (19 ARDS cases in a cohort of 48) resulted in an AUC of 0.78. Discrimination was insensitive to adjustment for severity of disease, a direct or indirect cause of ARDS, comorbidities, or ventilator settings. Combination with the lung injury prediction score increased the AUC to 0.91 and improved net reclassification by 1.17. Exhaled breath analysis showed good diagnostic accuracy for ARDS, which was externally validated. These data suggest that exhaled breath analysis could be used for the diagnostic assessment of ARDS. Metabolites in the breath of ventilated patients may be used to diagnose the acute respiratory distress syndrome http://ow.ly/uWHF1
Inhibition of HIV-1 enhancer-controlled transcription by artificial enhancer-binding peptides derived from bacteriophage 434 repressor.

An artificial HIV-1 enhancer-binding 42-residue peptide (R42) that had been derived from bacteriophage 434 repressor inhibited the cell-free in vitro transcription of HIV-1 enhancer-containing plasmids [Hehlgans, T. , Stolz, M. , Klauser, S. , Cui, T. , Salgam, P., Brenz Verca, S. , Widmann, M. , Leiser, A. , Städler, K. & Gutte, B. (1993) FEBS Lett. 315, 51-55; Caderas, G. (1997) PhD Thesis, University of Zürich]. Here we show that, after N-terminal extension of R42 with a viral nuclear localization signal, the resulting nucR42 peptide was active in intact cells. NucR42 could be detected immunologically in nuclear extracts and produced a 60-70% reduction of the rate of transcription of an HIV-1 enhancer-carrying plasmid in COS-1 cells that had been cotransfected with the HIV enhancer plasmid, an expression plasmid for nucR42, and a control. NucR42 was also synthesized chemically and the synthetic product characterized by HPLC, mass spectrometry, and quantitative amino acid analysis. Band shift, footprint, and in vitro transcription assays in the presence of exogenous NF-kappaBp50 indicated that the binding sites of nucR42 and NF-kappaB on the HIV enhancers overlapped and that a relatively small excess of nucR42 sufficed to displace NF-kappaBp50. Band shift and in vitro transcription experiments showed also that exchange of the 434 repressor-derived nine-residue recognition helix of nucR42 for four glycines abolished the HIV enhancer binding specificity whereas leucine zipper- or retro-leucine zipper-mediated dimerization of R42 analogues increased it suggesting the potential application of such dimeric HIV enhancer-binding peptides as intracellular inhibitors of HIV replication.
Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans

Background Emerging evidence suggests that microRNAs play a critical role in the pathogenesis of breast cancer. Several molecular epidemiological studies were conducted in recent years to evaluate the association between has-miR-146a rs2910164 polymorphism and breast cancer risk in diverse populations. However, the results remain conflicting rather than conclusive. Methodology/Principal findings We performed a meta-analysis of 6 case-control studies that included 4238 breast-cancer cases and 4469 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, this meta-analysis showed that the rs2910164 polymorphism was not associated with a significantly increased risk of breast cancer in all genetic models (for GC vs GG: OR = 1.00, 95% CI = 0.90−1.09, P heterpgeneity = 0.364; for CC vs GG: OR = 1.16, 95% CI = 0.98−1.36, P heterpgeneity = 0.757; for GC+CC vs GG: OR = 1.02, 95% CI = 0.93−1.12, P heterpgeneity = 0.562; for CC vs GC+GG: OR = 1.10, 95% CI = 0.96−1.26, P heterpgeneity = 0.441). However, in the stratified analysis by ethnicity, we found the rs2910164 polymorphism was associated with increased breast cancer risk among Europeans in homozygote comparison (CC vs. GG: OR = 1.29, 95%CI = 1.02−1.63, P heterpgeneity = 0.950, P = 0.032) and recessive model (CC vs. GC+GG: OR = 1.31, 95%CI = 1.05−1.65, P heterpgeneity = 0.839, P = 0.019). No publication bias was found in the present study. Conclusions/Significance This meta-analysis suggests, for the first time, that the CC homozygote of rs2910164 may contribute to breast cancer susceptibility in Europeans.
Recall Improvement in Information Storage and Retrieval System by Enhancing Query Knowledge

The main focus of this paper is the query knowledge improvement scheme for information storage and retrieval system to improve the recall. In information storage and retrieval system instead of searching query lexeme if we search query lexeme with its related lexeme then the recall value improved. Our hypothesis is that a meaning of a lexeme generally decided by its related lexeme for example the meaning of query containing the lexeme ―apple phone‖ is well describe by its related lexeme as ―audio‖, ―video‖, ―iphone‖, ― ipad‖ etc. Thus instead of searching the lexeme ―apple phone‖ if we search ―apple phone‖ with its related lexeme like ―audio‖, ―video‖, ―ipad‖, ―iphone‖ then recall value improved. From the result we have seen that by using the query lexeme with its related lexeme the recall value is improved by 28 percent.
Scale variance analysis coupled with Moran's I scalogram to identify hierarchy and characteristic scale

Scale variance is highly sensitive to multi-scale patterns of variables, which is advantageous in identifying spatial hierarchy and characteristic scale(s). However, the significance of peak(s) in scale variance cannot be statistically tested, and different spatial patterns may be obtained when different zoning systems are used to calculate scale variance. To address these two problems, this study compared the scale levels with peaks in scale variance and the scale levels at which there were breaks in the nature of spatial autocorrelation as identified by shifts in Moran's I scalogram. The estimates for three simulated landscapes showed that accordance between scale levels identified employing the two methods can be used to evaluate the significance of peaks in scale variance and choose a more reasonable zoning system. The approach of scale variance analysis coupled with Moran's I scalogram was also applied to the Xilin River Basin of Inner Mongolia, China. The most vital characteristic scale (64 × 32 km) identified for the growing-season net ecosystem productivity (NEP) of the basin was validated by other spatial pattern analysis methods such as semi-variogram, Moran's I correlogram, and wavelet variance analyses, and the directionality of the chosen zoning systems was found to be similar to the orientation of actual dominant vegetation type patches. The results demonstrate that Moran's I scalogram can be used to improve the interpretation of the results of scale variance analysis and increase the reliability of scale variance analysis for landscapes having a repetitive patch pattern or gradient variation and that the proposed approach is suitable for identifying the hierarchy and the characteristic scales of patterns or processes. In summary, this study used a simple approach to solve two problems in scale variance analysis, thereby improving the methodology and enhancing the theoretical basis of multi-scale analysis.
Multi-projector VR Systems

Immersive multi-projection environments are becoming affordable for many research centers, but these solutions needs several integration steps to be fully operational, and some of these steps are difficult and not in a common domain. This paper presents the most recent techniques involved in multi-projection solutions, from projection to computer cluster software. The hardware in these VR (Virtual Reality) installations is a connection of projectors, screen, speaker, computers and tracking devices. This survey paper will introduce hardware options, explaining their advantages and disadvantages. We will cover software design and open source tools available, and how to administrate the whole solution.
Male Infertility in the Era of ART: Why Treat; How to Treat

Recent dramatic advances in the diagnosis and treatment of male infertility have made it possible to achieve pregnancies in men who were previously considered to be untreatable or even sterile. Moreover, the elucidation of the molecular genetic underpinnings of spermatogenesis and the development of new sperm function tests have led to a better understanding of and to improved treatments for male infertility. Specifically, the advent of in vitro fertilization combined with intracytoplasmic sperm injection (IVF/ICSI) has revolutionized the treatment of even the most severely compromised males. Although IVF/ ICSI has allowed reproductive endocrinologists to treat couples with severe male factor infertility, it is important to emphasize that a careful urologic and genetic evaluation should be performed before IVF/ ICSI as recent studies have demonstrated a higher incidence of testicular cancer and/or genetic abnormalities in these men. In some instances, appropriate medical or surgical treatment can enhance sperm production whereas others with persistent nonobstructive azoospermia, in spite of vigorous treatment, may require testicular sperm extraction. Microsurgical management of obstructive azoospermia and of varicoceles, as well as microdissection testicular extraction, has made the achievement of pregnancies possible in scenarios that were unimaginable only a decade ago. In addition, many conditions associated with infertility, such as varicocele, have been shown to be associated with more rapid declines in testosterone levels compared with those in age-matched men without varicocele. Thus, treatment of these