Miracle-dz/UniFAR-FTUs huggingface dataset:
Stress and the HPA Axis

Stress has long been suggested to be an important correlate of uncontrolled drinking and relapse. An important hormonal response system to stress—the hypothalamic–pituitary–adrenal (HPA) axis—may be involved in this process, particularly stress hormones known as glucocorticoids and primarily cortisol. The actions of this hormone system normally are tightly regulated to ensure that the body can respond quickly to stressful events and return to a normal state just as rapidly. The main determinants of HPA axis activity are genetic background, early-life environment, and current life stress. Alterations in HPA axis regulation are associated with problematic alcohol use and dependence; however, the nature of this dysregulation appears to vary with respect to stage of alcohol dependence. Much of this research has focused specifically on the role of cortisol in the risk for, development of, and relapse to chronic alcohol use. These studies found that cortisol can interact with the brain’s reward system, which may contribute to alcohol’s reinforcing effects. Cortisol also can influence a person’s cognitive processes, promoting habit-based learning, which may contribute to habit formation and risk of relapse. Finally, cortisol levels during abstinence may be useful clinical indicators of relapse vulnerability in alcohol-dependent people.
IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.

AIMS Interleukin (IL)-17-producing helper T (Th17) cells have been proposed to participate in the pathogenesis of chronic inflammation, such as autoimmune myocarditis. IL-6 gene ablation confers the resistance to experimental autoimmune myocarditis (EAM). In this study, we have addressed the pathological roles of IL-6 in the regulation of Th17 cells in EAM. METHODS AND RESULTS To induce EAM, mice were immunized twice with α-myosin heavy chain peptide. Three weeks after the first injection, the cardiac expression of the Th17-specific transcription factor, retinoic acid receptor-related orphan nuclear receptor (ROR γt), was up-regulated. Consistently, Th17 cells were recruited into EAM hearts, as analysed by flow cytometry. Using the mice with enhanced green fluorescence protein (eGFP) gene knocked-in at RORγt locus (RORγt-eGFP mice), we observed Th17 cell infiltration into inflamed lesions. Pre-treatment with IL-6 receptor (IL-6R)-blocking antibody (anti-IL-6R Ab) inhibited EAM induction in terms of disease severity score (3.5 ± 0.8; IgG vs. 0.5 ± 0.8; anti-IL-6R Ab, n = 6, P< 0.01) and suppressed the myocardial expression of IL-17 and RORγt. In contrast, the administration of anti-IL-6R Ab 7 days after the first immunization failed to show the inhibitory effects, suggesting that IL-6 plays important roles in EAM initiation. Finally, by generating RORγt-eGFP homozygous mice, we revealed that RORγt gene ablation conferred the resistance to EAM induction. CONCLUSION IL-6-mediated induction of Th17 cells is critical for the onset of EAM, but not for its progression. IL-6/Th17 signalling could be a promising therapeutic target for the prevention of myocardial inflammation.
A popularity-driven controller-based routing and cooperative caching for named data networks

In this work, we investigate cache admission policies and forwarding decisions that account for content popularity in order to optimize the named-based routing performances in Named Data Networks (NDN). To achieve this goal, we propose a new controller-based, neighborhood content-aware, popularity-driven routing tightly coupled with a cooperative caching strategy, named Controller-Based Caching and Forwarding Scheme (CCFS). The rationale behind our proposal is to divide the network into domains mastered by cooperative Controllers forming a Connected Dominating Set (CDS). Controllers are responsible for making judicious request forwarding decisions while holding the most popular content requested in their domains. To gauge the effectiveness of our proposal, we conducted extensive simulations. Results show that CCFS reduces the mean hit distance by up to 30% and minimizes the communication cost by up to 47 times in comparison with a prominent existing approach - COntent-driven Bloom filter based Routing Algorithm (COBRA) as well as the default NDN routing. In addition, we observe that the performances of our proposal are very close to those achieved by the Best-route forwarding scheme using location-based Dijkstra's algorithm.
Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Objective: To develop a clinical practice guideline for red blood cell transfusion in adult trauma and critical care. Design: Meetings, teleconferences and electronic-based communication to achieve grading of the published evidence, discussion and consensus among the entire committee members. Methods: This practice management guideline was developed by a joint taskforce of EAST (Eastern Association for Surgery of Trauma) and the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM). We performed a comprehensive literature review of the topic and graded the evidence using scientific assessment methods employed by the Canadian and U.S. Preventive Task Force (Grading of Evidence, Class I, II, III; Grading of Recommendations, Level I, II, III). A list of guideline recommendations was compiled by the members of the guidelines committees for the two societies. Following an extensive review process by external reviewers, the final guideline manuscript was reviewed and approved by the EAST Board of Directors, the Board of Regents of the ACCM and the Council of SCCM. Results: Key recommendations are listed by category, including (A) Indications for RBC transfusion in the general critically ill patient; (B) RBC transfusion in sepsis; (C) RBC transfusion in patients at risk for or with acute lung injury and acute respiratory distress syndrome; (D) RBC transfusion in patients with neurologic injury and diseases; (E) RBC transfusion risks; (F) Alternatives to RBC transfusion; and (G) Strategies to reduce RBC transfusion. Conclusions: Evidence-based recommendations regarding the use of RBC transfusion in adult trauma and critical care will provide important information to critical care practitioners.
Research on Quantitative Evaluation for Integrity

Integrity is one of essential properties of information security. It is necessary to analyze integrity of system quantitatively in order to protect the system security. For the purpose, we present formal definitions of integrity based on probabilistic computation tree logic (PCTL) and quantitative evaluation model of integrity. In the model, we model interoperations of system and environment by probabilistic automata and evaluate integrity quantitatively by probabilistic model checking algorithm. Analysis results show that the formal description of integrity is of great significance and evaluation results are different with different integrity goals even for the same system.
A LOGISTIC PROCESS SCHEDULING PROBLEM: GENETIC ALGORITHMS OR ANT COLONY OPTIMIZATION?

Abstract This paper compares the optimization of a logistic scheduling problem using two different optimization techniques; the genetic algorithms and the ant colony optimization. The comparison is preceded by a literature review that summarizes the available comparison results for different benchmark problems and tries to generalize the differences between the techniques. The simulation results for the logistic problem confirm the conclusions of the literature survey: both methods perform equally well, but in general the genetic algorithms are faster. However, the ant colonies give more information about the solution, which is advantage in some applications.
Characteristics of Subjects with Very Low Serum Low-Density Lipoprotein Cholesterol and the Risk for Intracerebral Hemorrhage

Background/Aims The clinical implications of hypocholesterolemia have not been well studied, although some studies have revealed an association between hypocholesterolemia and intracerebral hemorrhage (ICH). We evaluated the clinical characteristics of subjects with very low-density lipoprotein cholesterol (LDL-C) and compared the risk for ICH using various clinical parameters. Methods Using hospital records, we evaluated the clinical characteristics of subjects with LDL-C levels ≤ 40 mg/dL (very low LDL-C group). We also evaluated the risk for ICH in this very low LDL-C group and in subjects with low LDL-C ≤ 70 mg/dL (low LDL-C group). Results Among 34,415 subjects who presented at the laboratory for serum LDL-C measurements, 250 subjects had a very low serum LDL-C level (≤ 40 mg/dL). About half of the subjects were statin users; the very low LDL levels in the other subjects were likely attributable to alcohol consumption or a various chronic illness such as liver disease or end-stage renal disease (ESRD). ICH occurred in three subjects with very low LDL-C, all of whom had no history of statin use. ESRD tended to be associated with ICH in subjects with serum LDL-C ≤ 70 mg/dL. Conclusions About 1% of the subjects whose LDL-C was measured in the hospital had a LDL-C level ≤ 40 mg/dL, and about half of these subjects had no history of hypolipidemic therapy. ICH incidence was not related to LDL-C level or statin use.
A 130-nm 6-GHz 256 × 32 bit leakage-tolerant register file

Describes a 256-word /spl times/ 32-bit 4-read, 4-write ported register file for 6-GHz operation in 1.2-V 130-nm technology. The local bitline uses a pseudostatic technique for aggressive bitline active leakage reduction/tolerance to enable 16 bitcells/bitline, low-V/sub t/ usage, and 50% keeper downsizing. Gate-source underdrive of -V/sub cc/ on read-select transistors is established without additional supply/bias voltages or gate-oxide overstress. 8% faster read performance and 36% higher dc noise robustness is achieved compared to dual-V/sub t/ bitline scheme optimized for high performance. Device-level measurements in the 130-nm technology show 703/spl times/ bitline active leakage reduction, enabling continued V/sub t/ scaling and robust bitline scalability beyond 130-nm generation. Sustained performance and robustness benefit of the pseudostatic technique against conventional dynamic bitline with keeper-upsizing is also presented.
Nested synchrony—a novel cross-scale interaction among neuronal oscillations

Neuronal interactions form the basis for our brain function, and oscillations and synchrony are the principal candidates for mediating them in the cortical networks. Phase synchrony, where oscillatory neuronal ensembles directly synchronize their phases, enables precise integration between separated brain regions. However, it is unclear how neuronal interactions are dynamically coordinated in space and over time. Cross-scale effects have been proposed to be responsible for linking levels of processing hierarchy and to regulate neuronal dynamics. Most notably, nested oscillations, where the phase of a neuronal oscillation modulates the amplitude of a faster one, may locally integrate neuronal activities in distinct frequency bands. Yet, hierarchical control of inter-areal synchrony could provide a more comprehensive view to the dynamical structure of oscillatory interdependencies in the human brain. In this study, the notion of nested oscillations is extended to a cross-frequency and inter-areal model of oscillatory interactions. In this model, the phase of a slower oscillation modulates inter-areal synchrony in a higher frequency band. This would allow cross-scale integration of global interactions and, thus, offers a mechanism for binding distributed neuronal activities. We show that inter-areal phase synchrony can be modulated by the phase of a slower neuronal oscillation using magnetoencephalography (MEG). This effect is the most pronounced at frequencies below 35 Hz. Importantly, changes in oscillation amplitudes did not explain the findings. We expect that the novel cross-frequency interaction could offer new ways to understand the flexible but accurate dynamic organization of ongoing neuronal oscillations and synchrony.
Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival

Summary We have demonstrated that the extensive degeneration of motoneurons in the rat facial nucleus after transection of the facial nerve in newborn rats can be prevented by local ciliary neurotrophic factor (CNTF) administration. CNTF differs distinctly from known neurotrophic molecules such as NGF, BDNF and NT-3 in both its molecular characteristics (CNTF is a cytosolic rather than a secretory molecule) and its broad spectrum of biological activities. CNTF is expressed selectively by Schwann cells and astrocytes of the peripheral and central nervous system, respectively, but not by target tissues of the great variety of CNTF-responsive neurons. CNTF mRNA is not detectable by Northern blot or PCR analysis during embryonic development and immediately after birth. However, during the second post-natal week, a more than 30-fold increase in CNTF mRNA and protein occurs in the sciatic nerve. Since the period of low CNTF levels in peripheral nerves coincides with that of high vulnerability of motoneurons (i.e. axonal lesion results in degeneration of motoneuron cell bodies), insufficient availability of CNTF may be the reason for the rate of lesion-induced cell death of early post-natal motoneurons. Highly enriched embryonic chick motoneurons in culture are supported at survival rates higher than 60 % by CNTF, even in single cell cultures, indicating that CNTF acts directly on motoneurons. In contrast to CNTF, the members of the neurotrophin gene family (NGF, BDNF and NT-3) do not support the survival of motoneurons in culture. However, aFGF and bFGF show distinct survival activities which are additive to those of CNTF, resulting in the survival of virtually all motoneurons cultured in the presence of CNTF and bFGF.
Retention in HIV Care for Individuals Not Yet Eligible for Antiretroviral Therapy: Rural KwaZulu-Natal, South Africa

Objectives: To determine retention in HIV care for individuals not yet eligible for antiretroviral therapy (ART) and to explore factors associated with retention in a rural public health HIV program. Methods: HIV-infected adults (≥16 years) not yet eligible for ART, with CD4 cell count >200 cells per microliter from January 2007 to December 2007 were included in the analysis. Retention was defined by repeat CD4 count within 13 months. Factors associated with retention were assessed using logistic regression with clustering at clinic level. Results: Four thousand two hundred twenty-three were included in the analysis (83.9% female). Overall retention was 44.9% with median time to return 201 days [interquartile range (IQR): 127-274]. Retention by initial CD4 count 201-350, 351-500, and >500 cells per microliter was 51.6% [95% confidence interval (CI): 49.1 to 54.0], 43.2% (95% CI: 40.5 to 45.9), and 34.9% (95% CI: 32.4 to 37.4), respectively. Compared with CD4 201-350 cells per microliter, higher initial CD4 count was significantly associated with lower odds of retention [CD4: 351-500 cells/μL adjusted odds ratio (aOR): 0.72, 95% CI: 0.62 to 0.84; CD4 >500 cells/μL aOR: 0.51, 95% CI: 0.44 to 0.60]. Male sex was independently associated with lower odds (aOR: 0.80, 95% CI: 0.67 to 0.96), and older age with higher odds of retention (for each additional year of age aOR: 1.03, 95% CI: 1.03 to 1.04). Conclusions: Retention in HIV care before eligibility for ART is poor, particularly for younger individuals and those at an earlier stage of infection. Further work to optimize and evaluate care and monitoring strategies is required to realize the full benefits of the rapid expansion of HIV programs in sub-Saharan Africa.
Contrasting effects of phosphatidylinositol 4,5‐bisphosphate on cloned TMEM16A and TMEM16B channels

Ca2+‐activated Cl− channels (CaCCs) are gated open by a rise in intracellular Ca2+ concentration ([Ca2+]i), typically provoked by activation of Gq‐protein coupled receptors (GqPCR). GqPCR activation initiates depletion of plasmalemmal phosphatidylinositol 4,5‐bisphosphate (PIP2). Here, we determined whether PIP2 acts as a signalling lipid for CaCCs coded by the TMEM16A and TMEM16B genes.
Surveillance for Waterborne Disease Outbreaks Associated with Drinking Water — United States, 2011–2012

Advances in water management and sanitation have substantially reduced waterborne disease in the United States, although outbreaks continue to occur. Public health agencies in the U.S. states and territories* report information on waterborne disease outbreaks to the CDC Waterborne Disease and Outbreak Surveillance System (http://www.cdc.gov/healthywater/surveillance/index.html). For 2011-2012, 32 drinking water-associated outbreaks were reported, accounting for at least 431 cases of illness, 102 hospitalizations, and 14 deaths. Legionella was responsible for 66% of outbreaks and 26% of illnesses, and viruses and non-Legionella bacteria together accounted for 16% of outbreaks and 53% of illnesses. The two most commonly identified deficiencies† leading to drinking water-associated outbreaks were Legionella in building plumbing§ systems (66%) and untreated groundwater (13%). Continued vigilance by public health, regulatory, and industry professionals to identify and correct deficiencies associated with building plumbing systems and groundwater systems could prevent most reported outbreaks and illnesses associated with drinking water systems.
Separating refusal bias and non-contact bias: evidence from UK national surveys

Refusal by sample units and failure to contact sample units can both contribute to survey non-response bias. However, the nature of the contribution can be rather different in the two cases. Extended field efforts may reduce either or both components of non-response bias. We examine data from several UK surveys on extended field efforts and the effect that they appear to have on non-response bias and its components. Some consistent patterns are found. We also explore the sensitivity of such analyses to the operational definition of extended efforts. The findings provide some evidence of the relative roles of refusal conversion and repeated contact attempts in reducing non-response bias. The study also has implications for the development of appropriate field strategies to combat non-response bias.
New concepts of the pathogenesis of cystic fibrosis lung disease

Although there has been impressive progress in the elucidation of the genetic and molecular basis of cystic fibrosis (CF), the pathogenesis of CF lung disease remains obscure. The elucidation of the pathogenesis of CF lung disease requires both a full description of normal innate airway defence and how absent function of the cystic fibrosis transmembrane regulator protein (CFTR) adversely perturbs this activity. Recent data have linked the abnormal ion transport properties of CF airway epithelia to depleted airway surface liquid (ASL) volume, reflecting the combined defects of accelerated Na+ transport and the failure to secrete Cl−. Depletion of a specific compartment of the ASL, i.e. the periciliary liquid (PCL), appears to abrogate both cilia-dependent and cough clearance. Subsequent to PCL depletion, mucus adheres to airway surfaces and persistent mucin secretion generates the formation of “thickened” mucus plaques and plugs, which become the nidus for bacterial infection. The paucity of liquid in these plaques/plugs, and the hypoxia in this environment, appear to promote biofilm bacterial infection. Therapeutic agents that restore airway surface liquid volume, i.e. blockers of Na+ transport, initiators of Cl− transport and osmolytes, are reviewed, as are strategies that may be required to use volume-restoring agents safely in patients with cystic fibrosis.
Towards Human-Like Bipedal Locomotion with Three-Segmented Elastic Legs

The long-term goal of the recently launched project BioBiped is to develop autonomous bipedal robots that are capable of energy-efficient multi-modal locomotion. In this paper we give a brief review of the important insights and techniques gained in previous and current projects leading to a new generation of human-like robots. Furthermore, we present the hardware design and the applied principles for the bipedal robot with three-segmented elastic legs that is currently under development. In the latter part of the paper we describe optimization methods that yield optimal parameter sets for tuning the walking and running gaits for a robot prototype with the same kinematic leg design.
Candidatus Frankia Datiscae Dg1, the Actinobacterial Microsymbiont of Datisca glomerata, Expresses the Canonical nod Genes nodABC in Symbiosis with Its Host Plant

Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be divided into three clusters, and this division also corresponds to host specificity groups. The strains of cluster II which form symbioses with actinorhizal Rosales and Cucurbitales, thus displaying a broad host range, show suprisingly low genetic diversity and to date can not be cultured. The genome of the first representative of this cluster, Candidatus Frankia datiscae Dg1 (Dg1), a microsymbiont of Datisca glomerata, was recently sequenced. A phylogenetic analysis of 50 different housekeeping genes of Dg1 and three published Frankia genomes showed that cluster II is basal among the symbiotic Frankia clusters. Detailed analysis showed that nodules of D. glomerata, independent of the origin of the inoculum, contain several closely related cluster II Frankia operational taxonomic units. Actinorhizal plants and legumes both belong to the nitrogen-fixing plant clade, and bacterial signaling in both groups involves the common symbiotic pathway also used by arbuscular mycorrhizal fungi. However, so far, no molecules resembling rhizobial Nod factors could be isolated from Frankia cultures. Alone among Frankia genomes available to date, the genome of Dg1 contains the canonical nod genes nodA, nodB and nodC known from rhizobia, and these genes are arranged in two operons which are expressed in D. glomerata nodules. Furthermore, Frankia Dg1 nodC was able to partially complement a Rhizobium leguminosarum A34 nodC::Tn5 mutant. Phylogenetic analysis showed that Dg1 Nod proteins are positioned at the root of both α- and β-rhizobial NodABC proteins. NodA-like acyl transferases were found across the phylum Actinobacteria, but among Proteobacteria only in nodulators. Taken together, our evidence indicates an Actinobacterial origin of rhizobial Nod factors.
A scoop from groups: Equational foundations for loops

Groups are usually axiomatized as algebras with an associative binary operation, a two-sided neutral element, and with two-sided inverses. We show in this note that the same simplicity of axioms can be achieved for some of the most important varieties of loops. In particular, we investigate loops of Bol-Moufang type in the underlying variety of magmas with two-sided inverses, and obtain "group-like" equational bases for Moufang, Bol and C-loops. We also discuss the case when the inverses are only one-sided and/or the neutral element is only one-sided.
Orbifold Riemann surfaces and the Yang-Mills-Higgs equations

We extend Hitchin's results on "The self-duality equations on a Riemann surface" (Proc. LMS (3), vol. 55, 1987) to orbifold Riemann surfaces. We prove existence results for orbifold solutions of the Yang-Mills-Higgs equations and construct the moduli space of solutions. These moduli spaces provide interesting examples of non-compact hyper-Kahler manifolds in all dimensions divisible by 4 and of completely integrable Hamiltonian systems. We also reinterpret these moduli spaces as spaces of orbifold Higgs bundles and as representation varieties of Fuchsian groups.