Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation of the input/output function of rat piriform cortex pyramidal cells.

1. In transverse brain slice preparations of rat piriform cortex, we characterized the repetitive firing properties of layer II pyramidal cells in control conditions (n = 78) and during perfusion of the cholinergic agonist carbachol (n = 26), with the ultimate goal of developing realistic computational simulations of the cholinergic modulation of the input/output function of these neurons. The response of neurons to prolonged (1 s) intracellular current injections was examined at a full range of current injection amplitudes, providing three-dimensional plots of firing frequency versus current amplitude versus time. 2. All neurons showed adaptation in response to intracellular current injection, with repetitive generation of action potentials at frequencies that were highest at the onset of the pulse and that decreased considerably thereafter. Substantial differences were observed between cells with regard to their rates of adaptation and the maximal number of action potentials they could generate during the current pulse. 3. The adaptation characteristics of each neuron were quantified by plotting the number of action potentials generated in 1 s as a function of the normalized current injection amplitude and measuring the area beneath this plot of the number of spikes versus current injection amplitude (S-I plot). This value was termed S-I value and allowed neurons to be plotted on a continuum including neurons showing strong adaptation (S-I value < 8.0) and neurons showing weak adaptation (S-I value > 8.0). The group showing weak adaptation contained 36% of the cells in control solution and 93.8% of the cells in 20 microM carbachol. 4. Neurons showing strong adaptation did not differ significantly from neurons showing weak adaptation in control conditions in measurements of resting potential, input resistance, threshold, and spike amplitude. Only a small difference was found in frequencies of firing measured soon after pulse onset (after 100 ms). This implies that differences in S-I values are primarily due to different rates of adaptation in later parts of the response. 5. Perfusion with solution containing the cholinergic agonist carbachol (2-100 microM) or 0 Ca2+ and 200 microM cadmium resulted in a substantial increase in the S-I values of neurons showing strong adaptation but had only a small effect on their initial firing rates. The effect on weakly adapting cells was smaller. In the presence of 20 microM carbachol, neurons showed a distribution shifted predominantly toward weak adaptation (n = 26). (ABSTRACT TRUNCATED AT 400 WORDS)
Objectives and Evaluation in Public Relations Work: What Do They Tell Us About Expertise and Professionalism?

This article investigates objectives and evaluations used in 111 prize-winning case studies to understand types of knowledge used in public relations and ways that the effectiveness of such a professional service is ascertained in practice. The discussion of the empirical findings is framed by ideas from the sociology of the professions, focusing specifically on the complex relationships between the professional body of knowledge, skills, and power strategies used by professional groups as well as ideas from the ongoing debate about evaluation in public relations. This article concludes by identifying 2 strategies in current practice: introspective focus and public performance.
US Welfare Reform: The Institutional Dimension

Making a success of welfare reform has as much to do with implementation as with policy design. The experience in Wisconsin and New York generalises too much of the US, with states divided into those successfully implementing work-based reform, those incapacitated by partisan divisions and those that have never seriously framed welfare policy. Three decisions are key: the degree of toughness, the amount of programme integration; and the locus of administrative control which are shaped by long standing differences in political culture, moralistic, individualistic and traditionalistic. States adopting a moralistic approach to policy administration generally achieve most success.
The key theorem of statistical learning theory of complex rough samples corrupted by noise

The key theorem plays an important role in the statistical learning theory. However, the researches about it at present mainly focus on real random variable and the samples which are supposed to be noise-free. In this paper, the definitions of complex rough variable and primary norm are introduced. Then, the definitions of the complex empirical risk functional, the complex expected risk functional, and complex empirical risk minimization principle about samples corrupted by noise are proposed. Finally, the key theorem of learning theory based on complex rough samples corrupted by noise is proposed and proved. The investigations help lay essential theoretical foundations for the systematic and comprehensive development of the statistical learning theory of complex rough samples.
Effects of embryo reduction from trichorionic triplets to twins

Sixty‐six trichorionic triplet pregnancies reduced to twins were compared with 47 triplet pregnancies that were not reduced. The miscarriage rate was higher (7.6% compared with 2.6%) but the number delivering between 24 and 32 weeks was lower (8.2% compared with 24.0%). Since severe preterm delivery is associated with risks of neonatal death and severe handicap, embryo reduction of triplets to twins may not improve the chance of survival but may reduce the rate of handicap.
Mosaic trisomy 13: understanding origin using SNP array

Background Trisomy 13 occurs in 1/10 000–20 000 live births, and mosaicism accounts for 5% of these cases. Phenotype and outcome of mosaic trisomy 13 are variable and poorly understood. Microsatellite analyses of trisomy 13 have indicated the high incidence of maternal meiotic origin and reduced recombination, but no study has focused on mosaic trisomy 13 in live born patients. Methods and results Single-nucleotide polymorphism (SNP) array, fluorescence in situ hybridisation and bioinformatics analyses were performed in three cases of mosaic trisomy 13. Two cases of complete mosaic trisomy 13 originated from meiosis I non-disjunction followed by trisomic rescue; one had crossovers resulting in segmental uniparental disomy in the disomic line, and one had no crossover. Mosaicism for partial trisomy 13 in the third complex case either arose from meiosis II non-disjunction without crossover or in early mitosis followed by anaphase lags. The extra chromosome 13 was maternal in origin in all three cases. Mosaicism percentage calculated from B allele frequencies ranged from 30 to 50. Conclusions Genotypes and copy number information provided by SNP array allow determination of parental origin and uniparental disomy status and direct quantification of mosaicism. Such information may lead to a better understanding of mechanisms underlying mosaic aneuploidies and the observed phenotypic variability and better prediction of recurrent risk.
The Interpretation of Cash Flow Reports and the Other Allocation Problem

Allocations continue to be a cause of concern to accountants. Allocations may be distributional (i.e. allocation of resources through budgets) or metrical (e.g. overhead costs to departments). Cash flow accounting is often advocated because it avoids metrical allocations. However, the interaction effects of cash flows may nullify their claimed advantages.
Foreign vs domestic investors and the post‐announcement drift

Purpose - This paper aims to investigate who causes post-announcement drift and whether this drift is observed for various types of news announcements. Design/methodology/approach - Using Finnish share ownership data, the authors examine the trading behavior of foreign and domestic investors during the post-announcement periods of scheduled earnings and unscheduled non-earnings announcements. Findings - The results show that the post-announcement drift exists for both types of news, but only if the news is negative. As a group, foreign investors react first by selling shares of firms reporting negative information. Domestic investors act in the opposite manner. Originality/value - The results imply that the post-announcement drift is a special case of a more general post-disclosure phenomenon and that investor differences (most likely information processing skills) is one likely explanation for its pervasiveness.
Impact of globalisation on entrepreneurial enterprises in the world markets

Globalisation has a significant impact on entrepreneurial enterprises in many ways. The changing international environment in finance, human resources, technology, politics, economics, and social conditions has created opportunities for the entrepreneurial enterprises to expand their international businesses at a much faster pace. Globalisation provides a great opportunity for entrepreneurial ventures to expand their business internationally. With the help of local governments, large corporations, and international organisations, entrepreneurial enterprises are able to confront the challenges posed by globalisation and economic liberalisation, to improve their competitiveness in the global market, and better serve the global consumers. A number of hypotheses are examined to understand how globalisation has affected the survival and sustainable development of entrepreneurial enterprises.
What Is a Life Worth? Robustness of VSL Values from Contingent Valuation Surveys

The value of a statistical life (VSL) is a key input for estimating the benefits of policies that save lives. Several recent studies have obtained estimates of the VSL from contingent valuation surveys, i.e., by asking people to say how much they would pay to reduce their risk of dying. This article examines statistical factors that may influence the estimates of the VSL obtained from such surveys. We examine the importance of distributional assumptions, the choice of the welfare statistics of interest, the procedure for computing them, outliers, undesirable response effects, and internal validity of the willingness‐to‐pay (WTP) responses. We illustrate the importance of these factors using dichotomous‐choice and open‐ended WTP data from four recent contingent valuation surveys.
Inner city engagement and the university: Mutuality, emergence and transformation

The potential transformative impact of university-based entrepreneurship programs on local economic development is examined using the example of a multifaceted inner city initiative. Using complex adaptive systems theory as a guiding framework, core elements of the South Side Entrepreneurial Connect Program (SSECP) are summarized. The emergence of parallel and interacting effects within the community and on the university campus are described, while underlying properties of the SSECP initiative contributing to these effects are specified. Qualitative and quantitative outcomes are specified at a number of levels within the community and the university. Based on the SSECP experience, ten principles are derived for use by entrepreneurship programmes and others involved with economic development and community engagement initiatives.
Inhibition of Cell-Free Human T-Cell Leukemia Virus Type 1 Infection at a Postbinding Step by the Synthetic Peptide Derived from an Ectodomain of the gp21 Transmembrane Glycoprotein

ABSTRACT To investigate the roles of human T-cell leukemia virus type 1 (HTLV-1) envelope (Env) proteins gp46 and gp21 in the early steps of infection, the effects of the 23 synthetic peptides covering the entire Env proteins on transmission of cell-free HTLV-1 were examined by PCR and by the plaque assay using a pseudotype of vesicular stomatis virus (VSV) bearing the Env of HTLV-1 [VSV(HTLV-1)]. The synthetic peptide corresponding to amino acids 400 to 429 of the gp21 Env protein (gp21 peptide 400-429, Cys-Arg-Phe-Pro-Asn-Ile-Thr-Asn-Ser-His-Val-Pro-Ile-Leu-Gln-Glu-Arg-Pro-Pro-Leu-Glu-Asn-Arg-Val-Leu-Thr-Gly-Trp-Gly-Leu) strongly inhibited infection of cell-free HTLV-1. By using the mutant peptide, Asn407, Ser408, and Leu413, -419, -424, and -429 were confirmed to be important amino acids for neutralizing activity of the gp21 peptide 400-429. Addition of this peptide before or during adsorption of HTLV-1 at 4°C did not affect its entry. However, HTLV-1 infection was inhibited about 60% when the gp21 peptide 400-429 was added even 30 min after adsorption of HTLV-1 to cells, indicating that the amino acid sequence 400 to 429 on the gp21 Env protein plays an important role at the postbinding step of HTLV-1 infection. In contrast, a monoclonal antibody reported to recognize the gp46 191-196 peptide inhibited the infection of HTLV-1 at the binding step.
MACROECONOMIC FACTORS, THE APT AND THE UK STOCKMARKET

This paper examines the macroeconomic sources of risk priced in the UK stockmarket between 1983 and 1990 using monthly data on 840 stocks to form both beta-sorted and market value sorted portfolios using the methodology proposed by Chen, Roll and Ross (1986) and Chan, Chen and Hsieh (1985) for the US. We find that several intuitively plausible macroeconomic variables were priced over this period using the beta sorted portfolios and that once these variables are included there is little role for the return on the market. However, when the market value sorted portfolios were used only inflation and a measure of equity market 'expense' relative to gilts was priced; furthermore with the market value sorted portfolios a role for the market return was found.
ON THE STABILITY OF CONTINUOUS‐TIME PORTFOLIO PROBLEMS WITH STOCHASTIC OPPORTUNITY SET

In this paper we present some counterexamples to show that an uncritical application of the usual methods of continuous‐time portfolio optimization can be misleading in the case of a stochastic opportunity set. Cases covered are problems with stochastic interest rates, stochastic volatility, and stochastic market price of risk. To classify the problems occurring with stochastic market coefficients, we further introduce two notions of stability of portfolio problems.
Integrated Reporting: An Opportunity for Australia's Not‐for‐Profit Sector

Integrated Reporting is a new reporting paradigm that is holistic, strategic, responsive, material and relevant across multiple time frames. Emphasising enhanced disclosure of the value drivers for today's organisations, Integrated Reporting represents a journey to more meaningful reporting that can be instrumental for Australia's reporting organisations, including not-for-profits. With momentum behind the concept of Integrated Reporting building and contemporaneous local regulatory reform on the agenda, there are nascent opportunities for Integrated Reporting to guide the future of not-for-profit reporting in Australia.
The determinants of work-related training in Britain in 1995 and the implications of employer size

This study uses a familiar set of variables to characterize the determinants of training (based around individual characteristics, qualifications, and workplace characteristics). However, it goes further by using data drawn from a recent quarter of the UK Labour Force Survey, and thus contains an up-to-date and extensive set of core variables. The dependent variable used covers three subgroups: those who have never been offered training by their current employer; those who have been offered but did not receive training in the last three months; and those workers who received training within the last three months. The hypothesis that large employers not only provide more work-related training, but that they are also more willing to train workers with characteristics that indicate a lower probability of obtaining a return on any investment outlay, is tested. This was confirmed (especially for male workers), along with a range of results that mostly accord with previous studies into the determinants of UK employer-based training.
Mastering mindfulness for survival in medicine

We all lead busy, frantic lives. We often get so caught up in our own thoughts that we don’t see what is happening around us. This tunnel vision is self-perpetuating, and we easily become disconnected from our surroundings and enter autopilot mode. This can be useful for getting things done efficiently. However, if your mind is constantly like a busy motorway that never slows down, the more likely you are to become exhausted, suffer the effects of stress and burn out. Mindfulness can be helpful for finding a place of calm among the chaos, especially in high-stress careers like medicine.
Sustainability versus liveability: an investigation of neighbourhood satisfaction

Recent years have witnessed an increasing emphasis placed on planning systems in most advanced capitalist societies to develop a more sustainable urban development pattern, resulting in policies to increase residential densities. Although belief in the virtues of the compact city approach is now widespread among the policy community, questions remain relating to the ‘sustainability versus liveability’ implications of compact city environments. In this regard, while the public may support sustainability principles, there is a perception that high-density development poses too great a cost on individuals' quality of life. Combining both quantitative and qualitative research data, this paper evaluates the relationship between high-density living and neighbourhood satisfaction within the central city. Findings suggest that, in many instances, it is not high density per se that is the source of dissatisfaction for respondents, but rather other related factors such as environmental quality, noise, lack of community involvement, traffic and lack of services and facilities.
The Power of Institutions

This article investigates the ways in which government activity, or demand-side forces, influence interest mobilization and formal inclusion in the policy-making process in the European Union. Drawing on an original dataset of nearly 700 civil society groups active in the European Union, the paper provides empirical evidence of three routes by which the EU institutions influence interest group activity: (1) direct interest group subsidy; (2) manipulation of the establishment and composition of formal arenas of political debate; and (3) broader, system-wide expansion of competencies and selective development of chosen policy areas.
p63α Mutations Lead to Aberrant Splicing of Keratinocyte Growth Factor Receptor in the Hay-Wells Syndrome*

p63, a p53 family member, is required for craniofacial and limb development as well as proper skin differentiation. However, p63 mutations associated with the ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome (Hay-Wells syndrome) were found in the p63 carboxyl-terminal region with a sterile α-motif. By two-hybrid screen we identified several proteins that interact with the p63α carboxyl terminus and its sterile α-motif, including the apobec-1-binding protein-1 (ABBP1). AEC-associated mutations completely abolished the physical interaction between ABBP1 and p63α. Moreover the physical association of p63α and ABBP1 led to a specific shift of FGFR-2 alternative splicing toward the K-SAM isoform essential for epithelial differentiation. We thus propose that a p63α-ABBP1 complex differentially regulates FGFR-2 expression by supporting alternative splicing of the K-SAM isoform of FGFR-2. The inability of mutated p63α to support this splicing likely leads to the inhibition of epithelial differentiation and, in turn, accounts for the AEC phenotype.
Profiling Local-Level Outcomes of Environmental Decentralizations: The Case of Cameroon’s Forests in the Congo Basin

Since the mid-1990s, Cameroon has launched a process of decentralization of the management of its forests. Among other innovations, this decentralization process has transferred powers over forests and financial benefits accruing from their exploitation to local communities. This article explores and profiles such local-level outcomes. It shows that the experiment has not yet brought up expected positive results and very often generates internal conflicts, a new social stratification and the marginalization of traditional authorities. Second, the article argues that decentralized management is not producing positive economic results, as there is no significant economic change in the case study villages. Third, it demonstrates that the experiment is leading to negative environmental results, such as the degradation of many community forests in the forested Cameroon. The author recommends that policy makers, researchers, nongovernmental organizations, and the local communities design a monitoring framework .
Coalition Policy in Parliamentary Democracies

This study investigates several hypotheses relating to the policy positions adopted by coalition governments in parliamentary democracies. Previous research, based on the comparative manifestos project's coding of party manifestos and coalition government declarations, has found that the linkage between the left-right positions of coalition governments and the positions of the parties that compose them is surprisingly weak. This investigation uses the same data to reveal a much closer correspondence between the two in West European systems. This linkage initially appeared to be weak because it is partially masked by additional influences on government policy emanating from the formateur party, the finance minister's party, the external support parties sustaining the government (if any), and the parliamentary center of gravity. In addition, government policy is affected by the position of the preceding government and shows a marked tendency to drift rightward with the passage of time since the last election.
How Do the Elderly Form Expectations? an Analysis of Responses to New Information

In this paper, I outline and test a simple theory that describes the evolution of expectations concerning social security benefits during the pre-retirement period. After correcting for the presences of measurement error, I obtain results that are consistent with this theory: expectations appear to evolve as a random walk, and innovations in this process are unrelated to previously available information. I also estimate responses of expectations to the arrival of new information. Although previous research indicates that individuals do not form expectations on the basis of all available information (and in particular ignore much of the information contained in concurrent statutory entitlements to social security benefits), responses to new information during the period immediately preceding retirement appear to be highly rational. The bulk of information affects the evolution of expectations only through its impact on actual benefit calculations. Furthermore, the data support the view that individuals form accurate assessments of the ultimate impact of new information on actual benefits.