Miracle-dz/UniFAR-FTUs huggingface dataset:
Unhealthy diets, obesity and time discounting: a systematic literature review and network analysis

There is an increasing policy commitment to address the avoidable burdens of unhealthy diet, overweight and obesity. However, to design effective policies, it is important to understand why people make unhealthy dietary choices. Research from behavioural economics suggests a critical role for time discounting, which describes how people's value of a reward, such as better health, decreases with delay to its receipt. We systematically reviewed the literature on the relationship of time discounting with unhealthy diets, overweight and obesity in Web of Science and PubMed. We identified 41 studies that met our inclusion criteria as they examined the association between time discount rates and (i) unhealthy food consumption; (ii) overweight and (iii) response to dietary and weight loss interventions. Nineteen out of 25 cross‐sectional studies found time discount rates positively associated with overweight, obesity and unhealthy diets. Experimental studies indicated that lower time discounting was associated with greater weight loss. Findings varied by how time discount rates were measured; stronger results were observed for food than monetary‐based measurements. Network co‐citation analysis revealed a concentration of research in nutrition journals. Overall, there is moderate evidence that high time discounting is a significant risk factor for unhealthy diets, overweight and obesity and may serve as an important target for intervention. © 2016 The Authors Obesity Reviews published by John Wiley & Sons Ltd on behalf of International Association for the Study of Obesity (IASO)
Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago.

OBJECTIVE Two polymorphisms in the promoter region of the gene encoding cytosolic aldehyde dehydrogenase (ALDH1A1), ALDH1A1*2 and ALDH1A1*3, have recently been identified. The present study sought to determine whether an association exists between ALDH1A1 genotypes, alcohol dependence, drinking history, and liver function tests in the two major ethnic groups of Trinidad and Tobago (TT). METHOD The participants in this study were 137 alcohol dependents of either East Indian ancestry (Indo-TT) or African ancestry (Afro-TT) and 108 controls matched by age, gender, and ethnicity. A structured interview was used to gather information on demographics, psychiatric diagnoses, and personal drinking and drug use. A blood sample was obtained from each participant, and leukocyte DNA was extracted and used to genotype for the presence of the ALDH1A1 promoter polymorphisms. Serum levels of hepatic enzymes, as well as presence of HIV, hepatitis B surface antigen, and antihepatitis C virus antibody, were also determined. RESULTS Twenty-four participants (10%) possessed the ALDH1A1*1/*2 genotype (frequency = .05), 4 were Afro-TT (2 alcohol dependents, 2 controls), and 20 were Indo-TT (18 alcohol dependents, 2 controls). Two participants (1 Indo-TT alcohol dependent, 1 Afro-TT alcohol dependent) had the ALDH1A1*2/*2 genotype. Four participants possessed ALDH1A1*3, all of whom were Afro-TT controls. Indo-TT participants with at least one ALDH1A1*2 allele were more likely to have a lifetime diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, alcohol dependence (p < .002). Indo-TT participants with ALDH1A1*2 also reported significantly higher levels of current alcohol consumption (p < .05). The small number of Afro-TT participants with atypical polymorphisms limits any conclusions on the possible impact on alcohol dependence in that population. CONCLUSIONS Results from this study suggest that ALDH1A1*2 may be associated with increased risk for the development of alcohol dependence in Indo-Trinidadians.
TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression

Purpose: TMEM16A is a calcium-activated chloride channel that is amplified in a variety of cancers, including 30% of head and neck squamous cell carcinomas (HNSCCs), raising the possibility of an anti-apoptotic role in malignant cells. This study investigated this using a multimodal, translational investigation. Experimental Design: Combination of (i) in vitro HNSCC cell culture experiments assessing cell viability, apoptotic activation, and protein expression (ii) in vivo studies assessing similar outcomes, and (iii) molecular and staining analysis of human HNSCC samples. Results: TMEM16A expression was found to correlate with greater tumor size, increased Erk 1/2 activity, less Bim expression, and less apoptotic activity overall in human HNSCC. These findings were corroborated in subsequent in vitro and in vivo studies and expanded to include a cisplatin-resistant phenotype with TMEM16A overexpression. A cohort of 41 patients with laryngeal cancer demonstrated that cases that recurred after chemoradiation failure were associated with a greater TMEM16A overexpression rate than HNSCC that did not recur. Conclusions: Ultimately, this study implicates TMEM16A as a contributor to tumor progression by limiting apoptosis and as a potential biomarker of more aggressive disease. Clin Cancer Res; 23(23); 7324–32. ©2017 AACR.
Polio Endgame : Information Gaps Related to Vaccines and Immunity

Evidence generated through research studies has guided programmatic actions and fine-tuned strategies for the Global Polio Eradication Initiative (GPEI). However, many gaps still persist in the understanding of a risk-free implementation of the polio endgame. Immediate concerns relate to the introduction of inactivated polio vaccine (IPV) and switch from trivalent oral polio vaccine (tOPV) to bivalent oral polio vaccine (bOPV) in routine immunization schedule. A comprehensive understanding of mucosal immunity in populations and best response options against circulating vaccine derived poliovirus (cVDPV) outbreaks in post tOPV-bOPV switch is essential to mitigate the risks of wild and vaccine-derived poliovirus importations and emergence of cVDPVs in polio-free countries. A clearer picture is also needed on few operational issues, interference between polio vaccines and other EPI vaccines and products related to polio endgame. It is also extremely important to develop mechanisms to identify and manage long-term poliovirus excretors who may pose a risk of reintroduction into the population after global eradication of poliovirus.
An interest control protocol for named data networking based on explicit feedback

Named Data Networking (NDN) is currently a hot research topic in the field of network architecture, and its transport control mechanism is one of the key technologies needed to be studied. Since the transport in NDN network has the characteristic of multi-source, the implicit congestion detection mechanism of the traditional TCP protocol is no longer suitable for the NDN network. In this paper, we propose a novel congestion control protocol for NDN network based on explicit feedback - ECP (Explicit Control Protocol), which detects the condition of network congestion proactively, and sends explicit feedback to the receiver. According to the feedback, the receiver can adjust the sending rate of Interests in order to control the sending rate of Datas from the sender, thus to realize the congestion control of the network. The simulation results based on NdnSIM show that the ECP protocol performs higher transfer efficiency and stability compared to the current NDN transport protocol using TCP implicit detection mechanism.
A robust and representative lower bound on object processing speed in humans

How early does the brain decode object categories? Addressing this question is critical to constrain the type of neuronal architecture supporting object categorization. In this context, much effort has been devoted to estimating face processing speed. With onsets estimated from 50 to 150 ms, the timing of the first face‐sensitive responses in humans remains controversial. This controversy is due partially to the susceptibility of dynamic brain measurements to filtering distortions and analysis issues. Here, using distributions of single‐trial event‐related potentials (ERPs), causal filtering, statistical analyses at all electrodes and time points, and effective correction for multiple comparisons, we present evidence that the earliest categorical differences start around 90 ms following stimulus presentation. These results were obtained from a representative group of 120 participants, aged 18–81, who categorized images of faces and noise textures. The results were reliable across testing days, as determined by test–retest assessment in 74 of the participants. Furthermore, a control experiment showed similar ERP onsets for contrasts involving images of houses or white noise. Face onsets did not change with age, suggesting that face sensitivity occurs within 100 ms across the adult lifespan. Finally, the simplicity of the face–texture contrast, and the dominant midline distribution of the effects, suggest the face responses were evoked by relatively simple image properties and are not face specific. Our results provide a new lower benchmark for the earliest neuronal responses to complex objects in the human visual system.
Evolving patch-based terrains for use in video games

Procedurally generating content for video games is gaining interest as an approach to mitigate rising development costs and meet users' expectations for a broader range of experiences. This paper explores the use of evolutionary algorithms to aid in the content generation process, especially the creation of three-dimensional terrain. We outline a prototype for the generation of in-game terrain by compiling smaller height-map patches that have been extracted from sample maps. Evolutionary algorithms are applied to this generation process by using crossover and mutation to evolve the layout of the patches. This paper demonstrates the benefits of an interactive two-level parent selection mechanism as well as how to seamlessly stitch patches of terrain together. This unique patch-based terrain model enhances control over the evolution process, allowing for terrain to be refined more intuitively to meet the user's expectations.
Rollenbasierte Kooperationsunterstützung in CSCL-Umgebungen

CSCL-Umgebungen, also technische Systeme zur Unterstutzung von Lernen in Gruppen, sind Mehrbenutzersysteme, fur die Nutzer in der Regel einen Zugang benotigen. Dafur sind als Bestandteil einer jeden CSCL-Umgebung Zugriffskontrollsysteme notwendig. Eine mogliche Herangehensweise sind rollenbasierte Zugriffskontrollsysteme, die Thema dieses Beitrags sind. Als Vorteile gelten gemeinhin eine aufgrund der Vermeidung von Mehrfachzuweisungen vereinfachte und gegenuber Fehlern robustere Administration von Zugriffsrechten sowie die Moglichkeit, Aspekte der Aufbauund Ablauforganisation eines Systems als strukturierende Metapher der Zugriffskontrolle zu verwenden. Rollenbasierte Zugriffskontrollsysteme konnen insbesondere reglementieren, welche Interaktionen in einer CSCL-Umgebung zu einem bestimmten Zeitpunkt moglich sind und stellen somit ein geeignetes Instrument zur Gestaltung lernforderlicher Situationen im Kontext prozessorientierten kollaborativen Lernens dar. Nach einer allgemeinen Begriffsbestimmung und Eingrenzung des Betrachtungsgegenstandes gehen wir auf den theoretischen Hintergrund rollenbasierter Kooperationsunterstutzungen ein, bevor wir auf technischer Ebene die Integration eines rollenbasierten Ansatzes in die CSCL-Umgebunge KOLUMBUS beleuchten. Anhand des Beispiels der Moderatorenrolle verdeutlichen wir abschliesend, wie sich Rollen in dem technischen System konkret darstellen.
Experimental Models of Endotheliopathy: Impact of Shock Severity

Background: Hemorrhagic shock (HS) followed by resuscitation is often associated with sympathoadrenal activation (SAA) and endothelial damage (ED). Objective: We aimed to evaluate the impact of HS alone on the magnitude of SAA and consecutive ED, and to characterize potential targets for a standardized and reproducible model of HS-induced endotheliopathy in rats. Methods: Rats were subjected either to a volume-controlled HS (40% of total blood volume: v-HS group) or to a laboratory-guided HS (l-HS) targeting base deficit (BD) more than 5.5 mmol/L and/or lactate more than 2.2 mmol/L using a pressure-controlled volume loss. Results: At the end of shock, mean arterial pressure was significantly higher in the v-HS than the l-HS group (36 ± 5.6 vs. 30 ± 3.0 mmHg; P < 0.01). Base deficit and lactate were higher in l-HS than the v-HS group (BD: 9.5 ± 2.5 vs. 3.0 ± 1.0 mmol/L; P < 0.001; lactate: 4.1 ± 1.3 vs. 1.6 ± 0.6 mmol/L; P < 0.001). sVEGFR-1 and syndecan-1 were approximately 50% higher in the l-HS than the v-HS group (% changes vs. baseline: 160 ± 10 vs. 116 ± 36; P < 0.01; 170 ± 37 vs. 113 ± 27; P < 0.001). Adrenaline was 2-fold higher in l-HS than the v-HS group (1964 ± 961% vs. 855 ± 451%; P < 0.02, respectively). Moreover, linear regression analysis revealed an independent association of shock severity BD with syndecan-1 (rho = 0.55, P = 0.0005), sVEGFR1 (rho = 0.25, P < 0.05), and adrenaline (rho = 0.31, P = 0.021). Conclusions: Our findings indicate that ED has already occurred during HS without reperfusion; intensity is strongly related to the severity of HS and consecutive SAA; and severity may appropriately be targeted and standardized in a HS model controlled by biological endpoints such as BD and/or lactate.
Grid Evolution Method for DOA Estimation

Off-grid direction of arrival (OGDOA) estimation methods deal with the situations where true direction of arrivals (DOAs) are not on the discretized sampling grid. However, existing OGDOA estimation methods are faced with a tradeoff between density of initial grid and computational workload. Furthermore, these methods fail if more than one true DOA is located in a same grid interval. In order to speed up the OGDOA estimation methods and solve the problem of more than one DOA in one initial grid interval, a grid evolution direction of arrival (GEDOA) estimation method is proposed. Based on the combination of OGDOA estimation methods and grid refinement, this new approach makes the grid nonuniformly evolve from coarse to dense. The proposed method contains two subprocesses, i.e., learning process and fission process. The learning process aims to update locations of grid points and estimate DOAs. The fission process aims to generate new grid points and guarantees that there is only one DOA in a grid interval. The two processes iterate alternatively. Finally, an adaptive and nonuniform grid and an estimated spatial spectrum based on this grid are achieved. Compared with the previous methods, GEDOA has better computational efficiency because fewer grid points are used at each iteration. Furthermore, GEDOA has better resolution and lower MSE at relative high SNR. This is because that the evolved grid obtained by this new approach is information adaptive. Numerical simulations validate the effectiveness of the proposed method.
Effectiveness of A Body Shape Index (ABSI) in predicting chronic diseases and mortality: a systematic review and meta‐analysis

Anthropometric measures are simple, inexpensive, noninvasive tools to assess the risk of morbidity and mortality. This systematic review assessed the performance of A Body Shape Index (ABSI) in predicting hypertension, cardiovascular disease, type 2 diabetes and all‐cause mortality and compared the differential predictability between ABSI and two other common anthropometric measures – body mass index and waist circumference. A keyword and reference search were conducted in the PubMed and Web of Science for articles published until 1 November 2017. Thirty‐eight studies were included in the review, including 24 retrospective cohort studies and 14 cross‐sectional studies conducted in 15 countries. Meta‐analysis found that a standard deviation increase in ABSI was associated with an increase in the odds of hypertension by 13% and type 2 diabetes by 35% and an increase in cardiovascular disease risk by 21% and all‐cause mortality risk by 55%. ABSI outperformed body mass index and waist circumference in predicting all‐cause mortality but underperformed in predicting chronic diseases. ABSI is highly clustered around the mean with a rather small variance, making it difficult to define a clinical cutoff for clinical practice. Future studies are warranted to assess ABSI's potential usefulness as an anthropometric measure in population‐level health surveillance.
Improving HIV test uptake and case finding with assisted partner notification services

Objective: Despite the enormous expansion of HIV testing services (HTS), an estimated 40% of people with HIV infection remain undiagnosed. To enhance the efficiency of HTS, new approaches are needed. The WHO conducted a systematic review on the effectiveness of assisted partner notification in improving HIV test uptake and diagnosis, and the occurrence of adverse events, to inform the development of normative guidelines. Methods: We systematically searched five electronic databases through June 2016. We also contacted experts in the field and study authors for additional information where needed. Eligible studies compared assisted HIV partner notification services to passive or no notification. Where multiple studies reported comparable outcomes, meta-analysis was conducted using a random-effects model to produce relative risks (RRs) or risk ratios and 95% confidence intervals (CIs). Results: Of 1742 citations identified, four randomized controlled trials and six observational studies totalling 5150 index patients from eight countries were included. Meta-analysis of three individually randomized trials showed that assisted partner notification services resulted in a 1.5-fold increase in HTS uptake among partners compared with passive referral (RR = 1.46; 95% CI: 1.22–1.75; I2 = 0%). The proportion of HIV-positive partners was 1.5 times higher with assisted partner notification than with passive referral (RR = 1.47; 95% CI: 1.12–1.92; I2 = 0%). Few instances of violence or harm occurred. Conclusion: Assisted partner notification improved partner testing and diagnosis of HIV-positive partners, with few reports of harm. WHO strongly recommends voluntary assisted HIV partner notification services to be offered as part of a comprehensive package of testing and care.
Preventive Measurement and Online Insulation Evaluation of Power Transformer

Cellulose based non conducting materials and mineral oils have widely been used in liquid filled transformers. Environmental and fire-safety concerns have accelerated the use of Natural Esters (NE) as a sustainable alternative to mineral oil. To ensure a safe and long-term operation of the vegetable oil filled transformers, it is need to clarify the knowledge gaps with respect to the ageing of vegetable oil impregnated cellulose and insulation diagnostic methods. The condition monitoring of mineral oil filled transformers has been well characterised, due to the numerous laboratory and field studies conducted during the past several decades. The application of these available condition monitoring techniques for NE filled transformers is yet to be validated as the use of NE for power transformers is in the tested stage. In this paper the performance of NE as insulation in transformers by evaluating the ageing of NE impregnated cellulose pressboard is presented. For this purpose, an accelerated ageing experiment has been carried out in sealed tubes at 120 ⁰C. The ageing of oil impregnated pressboard has been characterised by decrease in the degree of polymerisation (DP) of pressboard, and the formation of both 2-furfuraldehyde and dissolved carbon dioxide (CO2) in the oil. The structural changes of cellulose have been supported by fuzzy logic algorithm. Moreover, the results have been compared with cellulose insulation samples aged under similar conditions in conventional mineral oil.
Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus

ABSTRACT Staphylococcus aureus persistently colonizes the nasopharynx in humans, which increases the risk for invasive diseases, such as skin infection and bacteremia. Nasal colonization triggers IgG responses against staphylococcal surface antigens; however, these antibodies cannot prevent subsequent colonization or disease. Here, we describe S. aureus WU1, a multilocus sequence type 88 (ST88) isolate that persistently colonizes the nasopharynx in mice. We report that staphylococcal protein A (SpA) is required for persistence of S. aureus WU1 in the nasopharynx. Compared to animals colonized by wild-type S. aureus, mice colonized with the Δspa variant mount increased IgG responses against staphylococcal colonization determinants. Immunization of mice with a nontoxigenic SpA variant, which cannot cross-link B cell receptors and divert antibody responses, elicits protein A-neutralizing antibodies that promote IgG responses against colonizing S. aureus and diminish pathogen persistence. IMPORTANCE Staphylococcus aureus persistently colonizes the nasopharynx in about one-third of the human population, thereby promoting community- and hospital-acquired infections. Antibiotics are currently used for decolonization of individuals at increased risk of infection. However, the efficacy of antibiotics is limited by recolonization and selection for drug-resistant strains. Here, we propose a model of how staphylococcal protein A (SpA), a B cell superantigen, modifies host immune responses during colonization to support continued persistence of S. aureus in the nasopharynx. We show that this mechanism can be thwarted by vaccine-induced anti-SpA antibodies that promote IgG responses against staphylococcal antigens and diminish colonization.
Dengue knowledge, attitudes and practices and their impact on community-based vector control in rural Cambodia

Background Globally there are an estimated 390 million dengue infections per year, of which 96 million are clinically apparent. In Cambodia, estimates suggest as many as 185,850 cases annually. The World Health Organization global strategy for dengue prevention aims to reduce mortality rates by 50% and morbidity by 25% by 2020. The adoption of integrated vector management approach using community-based methods tailored to the local context is one of the recommended strategies to achieve these objectives. Understanding local knowledge, attitudes and practices is therefore essential to designing suitable strategies to fit each local context. Methods and findings A Knowledge, Attitudes and Practices survey in 600 randomly chosen households was administered in 30 villages in Kampong Cham which is one of the most populated provinces of Cambodia. KAP surveys were administered to a sub-sample of households where an entomology survey was conducted (1200 households), during which Aedes larval/pupae and adult female Aedes mosquito densities were recorded. Participants had high levels of knowledge regarding the transmission of dengue, Aedes breeding, and biting prevention methods; the majority of participants believed they were at risk and that dengue transmission is preventable. However, self-reported vector control practices did not match observed practices recorded in our surveys. No correlation was found between knowledge and observed practices either. Conclusion An education campaign regarding dengue prevention in this setting with high knowledge levels is unlikely to have any significant effect on practices unless it is incorporated in a more comprehensive strategy for behavioural change, such a COMBI method, which includes behavioural models as well as communication and marketing theory and practice. Trial registration ISRCTN85307778.