Miracle-dz/UniFAR-FTUs huggingface dataset:
Larval performance and adult phenotypic variation of Acraea terpsicore (Lepidoptera: Nymphalidae) on congeneric Passiflora host plants

The introduction of exotic plants into different habitats can have varied consequences for local herbivorous insects, such as altered the nutrient profiles that induce the host plant shifting or reduced food availability by competition with native plants. Acraea terpsicore (Linnaeus, 1758), a common butterfly in Southeast Asia that uses Passiflora as a host plant, has been studied to compare larval performance and adult phenotypes on one local wild Passiflora plant, P. foetida and 3 exotic congeneric plants, P. edulis, a fruit crop plant, and P. x alata-caerulea and P. x coccinea-caerulea, both hybrid ornamental plants. Laboratory caterpillars that fed on P. edulis and P. x alata-caerulea died within 1–10 days, while caterpillars fed on P. foetida and P. x coccinea-caerulea completed their life cycle in 30.42 ± 0.25 days. Although the caterpillars differed in several food utilization indices, the relative growth rate and consumption index were not affected. Adult butterflies that hatched from caterpillars fed on these experimental plants had different phenotypes, especially wing colors. Therefore, although some congeneric exotic plants may have a negative impact on the butterfly population, some exotic plants can serve as alternative larval host plants and expand the ecological niche of butterflies. Difference in the composition and concentration of nutrients and defensive chemicals in each host plant may exert an impact on the phenotypic traits of butterflies, such as their body size, coloration, and wing shape. Whether butterflies may separate into different subpopulations in the future due to phenotypic variation should be further examined.
Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche

ABSTRACT Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome. Nevertheless, the link between early androgen excess and these risk factors remains unknown. Epigenetic modifications, and specifically DNA methylation, have been associated with the initiation and progression of numerous disorders, including obesity and insulin resistance. The aim of this study was to determine if prepubertal androgen exposure is associated with a different methylation profile in pubertal girls. Eighty-six healthy girls were studied. At age 7 y, anthropometric measurements were begun and DHEAS levels were determined. Girls were classified into Low DHEAS (LD) [<42 μg/dL] and High DHEAS (HD) [≥42 μg/dL] groups. At Tanner stages 2 and 4 a DNA methylation microarray was performed to identify differentially methylated CpG positions (DMPs) between HD and LD groups. We observed a differential methylation pattern between pubertal girls with and without biochemical PA. Moreover, a set of DNA methylation markers, selected by the LASSO method, successfully distinguished between HD and LD girls regardless of Tanner stage. Additionally, a subset of these markers were significantly associated with glucose-related measures such as insulin level, HOMA-IR, and glycaemia. This pilot study provides evidence consistent with the hypothesis that high DHEAS concentration, or its hormonally active metabolites, may induce a unique blood methylation signature in pubertal girls, and that this methylation pattern is associated with altered glucose metabolism.
On the Analysis of Bivariate Non‐Stationary Processes

In this paper, we propose a general definition of the evolutionary (time dependent) cross-spectrum between two non-stationary processes and describe its physical interpretation. We also study the estimation of the evolutionary cross-spectrum at each time instant t from a single realization of a bivariate process. Further, we propose a definition (and a method of estimation) for the coherency (spectrum) between the two components of the bivariate process and show that the notion of residual variance bound first introduced in the analysis of bivariate stationary processes can be extended to that of non-stationary processes. As an application of the evolutionary cross-spectral analysis of bivariate non-stationary stochastic processes, we consider the estimation of the transfer function of a linear open-loop time dependent system. Numerical illustrations of the estimation of a time dependent transfer function are included.
Fault Diagnosis of Gyroscope Based on Estimated Angular Rate

To diagnose the gyro fault when the redundancy of the gyro in inertial measuring unit could not meet the requirement of odd-even equation, the nonlinear extended Kalman filter was adopted to gain the estimated angular rate according to the kinematic and dynamic equations of satellite attitude and attitude quaternion output from the high accuracy star sensor during the satellite running in stable state. On the basis of this, the gyro fault could be located by the fault diagnosing unit designed. The simulation results showed that this method could diagnose both abrupt and slow change fault of gyro.
Appropriateness of Recommendations Provided by ChatGPT to Interventional Radiologists

Purpose: The purpose of this study was to analyze the answers provided by ChatGPT to various questions in the field of interventional radiology (IR) and compare their correctness to a consensus of three interventional radiologists. Materials and Methods. Twenty questions were proposed to the online chat based ChatGPT about interventional radiology as indications for exams, complications and technical points. Answers were independently evaluated by 3 experts in interventional radiology with 10, 15 and 30 years or experiences and classified as correct, almost correct, or wrong. Results: Considering the consensus between the two IR, nine (9/20; 45%) were considered wrong, three (3/20; 15%) were considered almost correct and eight (8/20; 40%) were considered correct. Conclusion: ChatGPT can be useful in IR but the users must be aware of limitations such as too vague or inaccurate answers for the majority of questions.
The central role of the left inferior longitudinal fasciculus in the face‐name retrieval network

Unsuccessful retrieval of proper names (PNs) is commonly observed in patients suffering from neurological conditions such as stroke or epilepsy. While a large body of works has suggested that PN retrieval relies on a cortical network centered on the left anterior temporal lobe (ATL), much less is known about the white matter connections underpinning this process. Sparse studies provided evidence for a possible role of the uncinate fasciculus, but the inferior longitudinal fasciculus (ILF) might also contribute, since it mainly projects into the ATL, interconnects it with the posterior lexical interface and is engaged in common name (CN) retrieval. To ascertain this hypothesis, we assessed 58 patients having undergone a neurosurgery for a left low‐grade glioma by means of a famous face naming (FFN) task. The behavioural data were processed following a multilevel lesion approach, including location‐based analyses, voxel‐based lesion‐symptom mapping (VLSM) and disconnection‐symptom mapping. Different statistical models were generated to control for sociodemographic data, familiarity, biographical knowledge and control cognitive performances (i.e., semantic and episodic memory and CN retrieval). Overall, VLSM analyses indicated that damage to the mid‐to‐anterior part of the ventro‐basal temporal cortex was especially associated with PN retrieval deficits. As expected, tract‐oriented analyses showed that the left ILF was the most strongly associated pathway. Our results provide evidence for the pivotal role of the ILF in the PN retrieval network. This novel finding paves the way for a better understanding of the pathophysiological bases underlying PN retrieval difficulties in the various neurological conditions marked by white matter abnormalities.
Acute Performance, Daily Well-Being, and Hormone Responses to Water Immersion After Resistance Exercise in Junior International and Subelite Male Volleyball Athletes

Abstract Horgan, BG, Tee, N, West, NP, Drinkwater, EJ, Halson, SL, Colomer, CME, Fonda, CJ, Tatham, J, Chapman, DW, and Haff, GG. Acute performance, daily well-being and hormone responses to water immersion after resistance exercise in junior international and subelite male volleyball athletes. J Strength Cond Res 37(8): 1643–1653, 2023—Athletes use postexercise hydrotherapy strategies to improve recovery and competition performance and to enhance adaptative responses to training. Using a randomized cross-over design, the acute effects of 3 postresistance exercise water immersion strategies on perceived recovery, neuromuscular performance, and hormone concentrations in junior international and subelite male volleyball athletes (n = 18) were investigated. After resistance exercise, subjects randomly completed either 15-minute passive control (CON), contrast water therapy (CWT), cold (CWI), or hot water immersion (HWI) interventions. A treatment effect occurred after HWI; reducing perceptions of fatigue (HWI > CWT: p = 0.05, g = 0.43); improved sleep quality, compared with CON (p < 0.001, g = 1.15), CWI (p = 0.017, g = 0.70), and CWT (p = 0.018, g = 0.51); as well as increasing testosterone concentration (HWI > CWT: p = 0.038, g = 0.24). There were trivial to small (p < 0.001–0.039, g = 0.02–0.34) improvements (treatment effect) in jump performance (i.e., squat jump and countermovement jump) after all water immersion strategies, as compared with CON, with high variability in the individual responses. There were no significant differences (interaction effect, p > 0.05) observed between the water immersion intervention strategies and CON in performance (p = 0.153–0.99), hormone (p = 0.207–0.938), nor perceptual (p = 0.368–0.955) measures. To optimize recovery and performance responses, e.g., during an in-season competition phase, postresistance exercise HWI may assist with providing small-to-large improvements for up to 38 hours in perceived recovery (i.e., increased sleep quality and reduced fatigue) and increases in circulating testosterone concentration. Practitioners should consider individual athlete neuromuscular performance responses when prescribing postexercise hydrotherapy. These findings apply to athletes who aim to improve their recovery status, where postresistance exercise HWI optimizes sleep quality and next-day perceptions of fatigue.
F = ma. Is the macaque brain Newtonian?

ABSTRACT Intuitive Physics, the ability to anticipate how the physical events involving mass objects unfold in time and space, is a central component of intelligent systems. Intuitive physics is a promising tool for gaining insight into mechanisms that generalize across species because both humans and non-human primates are subject to the same physical constraints when engaging with the environment. Physical reasoning abilities are widely present within the animal kingdom, but monkeys, with acute 3D vision and a high level of dexterity, appreciate and manipulate the physical world in much the same way humans do.
Multi-Terrains Assistive Force Parameter Optimization Method for Soft Exoskeleton

Due to the complexity of terrain in natural environments, the soft exoskeleton cannot adaptively adjust parameters to achieve the optimal performance. To this end, a design for a soft exoskeleton assistive force parameter optimization method on multi-terrains is presented in this paper. Firstly, the core control parameters are determined by analyzing the system’s motion dynamics. Then, the collected data from inertial measurement unit (IMU) is transferred to the convolutional neural network (CNN) to recognize the certain terrain. In the meanwhile, the control parameters corresponding to the different terrains are optimized by the Bayesian algorithm. Finally, the optimal assistive force parameters are transferred to the system for improving the performance of the soft exoskeleton. The experiment is conducted on three participants, wherein the net metabolic rates of the subjects are compared with and without the assistive force. The final results show that the metabolic rates of the subjects reduce the average value of 19.6% on flat ground, 11.6% on walking uphill, and 12.7% on walking upstairs. The experimental results confirm the effectiveness of the proposed method.
Course of recovery of respiratory muscle strength and its associations with exercise capacity and handgrip strength: A prospective cohort study among survivors of critical illness

Background Mechanical ventilation affects the respiratory muscles, but little is known about long-term recovery of respiratory muscle weakness (RMW) and potential associations with physical functioning in survivors of critical illness. The aim of this study was to investigate the course of recovery of RMW and its association with functional outcomes in patients who received mechanical ventilation. Methods We conducted a prospective cohort study with 6-month follow-up among survivors of critical illness who received ≥ 48 hours of invasive mechanical ventilation. Primary outcomes, measured at 3 timepoints, were maximal inspiratory and expiratory pressures (MIP/MEP). Secondary outcomes were functional exercise capacity (FEC) and handgrip strength (HGS). Longitudinal changes in outcomes and potential associations between MIP/MEP, predictor variables, and secondary outcomes were investigated through linear mixed model analysis. Results A total of 59 participants (male: 64%, median age [IQR]: 62 [53–66]) were included in this study with a median (IQR) ICU and hospital length of stay of 11 (8–21) and 35 (21–52) days respectively. While all measures were well below predicted values at hospital discharge (MIP: 68.4%, MEP 76.0%, HGS 73.3% of predicted and FEC 54.8 steps/2m), significant 6-month recovery was seen for all outcomes. Multivariate analyses showed longitudinal associations between older age and decreased MIP and FEC, and longer hospital length of stay and decreased MIP and HGS outcomes. In crude models, significant, longitudinal associations were found between MIP/MEP and FEC and HGS outcomes. While these associations remained in most adjusted models, an interaction effect was observed for sex. Conclusion RMW was observed directly after hospital discharge while 6-month recovery to predicted values was noted for all outcomes. Longitudinal associations were found between MIP and MEP and more commonly used measures for physical functioning, highlighting the need for continued assessment of respiratory muscle strength in deconditioned patients who are discharged from ICU. The potential of targeted training extending beyond ICU and hospital discharge should be further explored.
Modulation of Northwest Pacific Tropical Cyclone Genesis by the Intraseasonal Variability

The modulation of tropical cyclone (TC) genesis over the western North Pacific (WNP) by the intraseasonal variability (ISV) is investigated in this study. The two leading ISV modes, i.e., the 40-day Madden–Julian oscillation (MJO) and the 16-day quasi-biweekly oscillation, are found to exert significant impacts on TC genesis over the WNP. A majority of TC geneses over the WNP is found to occur during the period when both the modes are active, suggesting a joint influence of the two modes on TC genesis over the WNP. The modulation of TC genesis over the WNP by the two leading ISV modes can be well depicted by the genesis potential index (GPI). Contributions of the four terms to the total GPI anomalies are further analyzed to determine the key factors involved in modulations of TC genesis by both of the ISV modes. Results indicate that while, in general, the low-level absolute vorticity and the mid-level relative humidity are the two most important factors affecting WNP TC genesis, relative roles of the four GPI factors also tend to be dependent on the ISV phases. This study provides further understanding of the ISV modulation of WNP TC genesis, which could benefit the intraseasonal prediction of the TC activity.
Associations between aberrant working memory-related neural activity and cognitive impairments in somatically healthy, remitted patients with mood disorders

Abstract Background Persistent cognitive deficits are prevalent in patients with bipolar disorder (BD) and unipolar disorder (UD), but treatments effectively targeting cognition in these mood disorders are lacking. This is partly due to poor insight into the neuronal underpinnings of cognitive deficits. Methods The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the neuronal underpinnings of working memory (WM)-related deficits in somatically healthy, remitted patients with BD or UD (n = 66) with cognitive and functional impairments compared to 38 healthy controls (HC). The participants underwent neuropsychological testing and fMRI, while performing a visuospatial and a verbal N-back WM paradigm. Results Relative to HC, patients exhibited hypo-activity across dorsolateral prefrontal cortex as well as frontal and parietal nodes of the cognitive control network (CCN) and hyper-activity in left orbitofrontal cortex within the default mode network (DMN) during both visuospatial and verbal WM performance. Verbal WM-related response in the left posterior superior frontal gyrus (SFG) within CCN was lower in patients and correlated positively with out-of-scanner executive function performance across all participants. Conclusions Our findings suggest that cognitive impairments across BD and UD are associated with insufficient recruitment of task-relevant regions in the CCN and down-regulation of task-irrelevant orbitofrontal activity within the DMN during task performance. Specifically, a lower recruitment of the left posterior SFG within CCN during verbal WM was associated with lower cognitive performance.
Novel behaviour change frameworks for digital health interventions: A critical review

Digital health interventions – interventions delivered over digital media to support the health of users – are becoming increasingly prevalent. Utilising an intervention development framework can increase the efficacy of digital interventions for health-related behaviours. This critical review aims to outline and review novel behaviour change frameworks that guide digital health intervention development. Our comprehensive search for preprints and publications used PubMed, PsycINFO, Scopus, Web of Science and the Open Science Framework repository. Articles were included if they: (1) were peer-reviewed; (2) proposed a behaviour change framework to guide digital health intervention development; (3) were written in English; (4) were published between 1/1/19 and 1/8/2021; and (5) were applicable to chronic diseases. Intervention development frameworks considered the user, intervention elements and theoretical foundations. However, the timing and policy of interventions are not consistently addressed across frameworks. Researchers should deeply consider the digital applicability of behaviour change frameworks to improve intervention success.
CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression

Abstract Aims Haploinsufficiency of the chromo-domain protein CHD7 underlies most cases of CHARGE syndrome, a multisystem birth defect including congenital heart malformation. Context specific roles for CHD7 in various stem, progenitor, and differentiated cell lineages have been reported. Previously, we showed severe defects when Chd7 is absent from cardiopharyngeal mesoderm (CPM). Here, we investigate altered gene expression in the CPM and identify specific CHD7-bound target genes with known roles in the morphogenesis of affected structures. Methods and results We generated conditional KO of Chd7 in CPM and analysed cardiac progenitor cells using transcriptomic and epigenomic analyses, in vivo expression analysis, and bioinformatic comparisons with existing datasets. We show CHD7 is required for correct expression of several genes established as major players in cardiac development, especially within the second heart field (SHF). We identified CHD7 binding sites in cardiac progenitor cells and found strong association with histone marks suggestive of dynamically regulated enhancers during the mesodermal to cardiac progenitor transition of mESC differentiation. Moreover, CHD7 shares a subset of its target sites with ISL1, a pioneer transcription factor in the cardiogenic gene regulatory network, including one enhancer modulating Fgf10 expression in SHF progenitor cells vs. differentiating cardiomyocytes. Conclusion We show that CHD7 interacts with ISL1, binds ISL1-regulated cardiac enhancers, and modulates gene expression across the mesodermal heart fields during cardiac morphogenesis.
A Self-Help Virtual Therapeutic Experience Intervention for Overcoming Psychological Distress Related to the COVID-19 Pandemic: Results From the European Multicentric COVID Feel Good Trial

ABSTRACT Objective The general objective of the current study was to investigate the efficacy of a novel self-help virtual therapeutic experience (specifically, the COVID Feel Good intervention) in lowering the psychological burden experienced during the COVID-19 lockdowns in four European countries. Methods We focused on participants recruited from June 2020 to May 2021 in the context of a European multicenter project including four university/academic sites. The total number of participants in the longitudinal studies was 107 (study 1, N = 40; study 2, N = 29; study 3, N = 38). The randomized controlled trial (study 4) included 31 participants in total, 16 in the intervention group and 15 in the control group. Primary outcome measures were depression, anxiety, stress symptoms, perceived stress level, and perceived hopelessness. The secondary outcome was experienced social connectedness. Results Using separate linear mixed-effects models, the most consistent result across countries was a reduction in perceived stress after the participation in the COVID Feel Good intervention. By pooling the results of the models using a random-effects meta-analysis, we found that after the COVID Feel Good intervention, participants reported a decrease in perceived general distress (mean standardized effect size for general distress in the treatment groups compared with the control conditions was −0.52 [p = .008, 95% confidence interval = −0.89 to −0.14]) and an increase in the perceived social connection (mean standardized effect size for social connection using COVID Feel Good compared with the control conditions was 0.50 [p ≤ .001, 95% confidence interval = 0.25 to 0.76]). Conclusions Findings of this study indicate that a virtual self-help intervention is effective in reducing psychological distress. These results contribute to the growing literature supporting the use of digital psychological therapies to relieve psychological distress among the general population during the COVID-19 pandemic. Trial Registration: ISRCTN63887521.