Miracle-dz/UniFAR-FTUs huggingface dataset:
Prostatectomy using different lasers for the treatment of benign prostate hyperplasia in aging males

Purpose Endoscopic lasers have become a treatment option for benign prostate hyperplasia (BPH). The study reported here sought to elucidate the benefits and drawbacks of different laser systems in the treatment of patients with BPH. Methods The study enrolled 741 patients diagnosed with lower urinary tract symptoms secondary to BPH during the period January 2005 to December 2011. The techniques used in the study were photoselective vaporization of the prostate, thulium laser prostatectomy, and diode laser prostatectomy. Patients were assigned to one of three groups according to the type of laser treatment they received. Outcomes were evaluated using the International Prostate Symptom Score (IPSS), quality of life, maximal urinary flow rate, post-voiding residual urine volume, and prostate-specific antigen (PSA) level. Results The baseline characteristics of patients who received diode laser prostatectomy show a significant elevated risk and high American Society of Anesthesiology score (P=0.001). Operative time and catheter removal time differed significantly between the three groups (P=0.001). No cases were converted to transurethral resection of the prostate intraoperatively due to bleeding (P=0.142). Among the three groups, there were no significant differences in maximal flow rate, lower post-void residual urine, and postoperative PSA level during the entire follow-up period (P<0.05). Further, no significant differences in postoperative IPSS, quality of life, or bladder neck contracture (P=0.23) were observed. However, a significant difference was observed with regard to prolonged use of Foley catheters and prolonged hospital stay among patients in the diode laser group (P=0.001). Conclusion Laser prostatectomies are effective in dealing with lower urinary tract symptoms. Early subjective functional results (maximal flow rate, IPSS, and post-void residual urine) appeared the same as those obtained following laser prostatectomy. Thus, it appears that lasers are safe and effective as long as the patients are carefully selected for treatment.
A new deep-sea Cirripedia of the genus Heteralepas from the northeastern Atlantic

A new species of the sessile deep-sea barnacle, Heteralepas (Crustacea, Cirripedia), Heteralepas gettysburgensis sp. nov., is described. The specimens were collected at a depth of 225 m at the Gettysburg Seamount on the Gorringe Bank, located in the Portuguese Exclusive Economic Zone, approximately 200 km off the southwestern coast of mainland Portugal. Extensive morphological and molecular (COI, 12S and 16S) analyses were carried out to separate the species from its nearest congeners with similar geographic distribution, i.e., Atlantic waters.
Information Technology Literacy: Implications on Teaching and Learning

This paper aims to discuss the role and impact that information technology (IT) has on the future and existing style of learning and teaching. It highlights the importance of acquiring computer skills and being literate in IT. The focus is put on certain areas related to IT and education which include pedagogy and training to build IT literacy among both educators and learners. Particularly, it covers the current trends in IT development and how it has started to change and will further influence the way learning and teaching will take place in the future. This paper also discusses various theoretical frameworks and methodologies designed to cope with progress in IT. In summary, this paper delivers a message that IT literacy is the key to today’s empowerment and that education is the best foundation for it.
Interzone microtubule behavior in late anaphase and telophase spindles

We have studied microtubule behavior in late anaphase and telophase spindles of PtK1 cells, using fluoresceinated tubulin (DTAF-tubulin), microinjection, and laser microbeam photobleaching. We present the results of two novel tests which add to the evidence that DTAF-tubulin closely mimics the behavior of native tubulin in vivo. (a) Microinjected DTAF-tubulin was as effective as injected native tubulin in promoting division of taxol-dependent mitotic mutant cells that had been deprived of taxol. (b) Microinjected colchicine-DTAF-tubulin complex was similar to injected colchicine-native tubulin complex in causing depolymerization of spindles. Immediately after microinjection of DTAF-tubulin into wild-type cells during late anaphase or telophase, fluorescence incorporation by microtubules was seen in chromosomal half- spindles and just behind the chromosomes, but there was no fluorescence incorporation near the middle of the interzone. Over the next few minutes, tubulin fluorescence accumulated at the center of the interzone (the equator), becoming progressively more intense. In other experiments, cells were microinjected with DTAF-tubulin at prophase and allowed to equilibrate for 30 min. Cells that had progressed to late anaphase were then photobleached to reduce the fluorescence in the central portion of the interzone. Over a period of several minutes, the only substantial redistribution of fluorescence was the appearance of a bright area at the equator of the interzone. Both the site of fluorescence incorporation and the photobleaching data suggest that tubulin adds to the elongating spindle interzone near the equator where the plus ends of the interdigitated microtubules are located. In further experiments, several dark lines were photobleached perpendicular to the pole-to-pole axis of fluorescent anaphase- telophase spindles. Time-dependent changes in the spacings between the lines indicated that the two halves of the interzone lying on opposite sides of the spindle equator moved away from one another. This shows that the interdigitated microtubules, which make up most of the interzone, can undergo antiparallel sliding. Our data support a model for anaphase B in which plus end elongation of interdigitated microtubules and antiparallel sliding contribute to chromosome separation.
Analysis of fitness noise in particle swarm optimization: From robotic learning to benchmark functions

Population-based learning techniques have been proven to be effective in dealing with noise and are thus promising tools for the optimization of robotic controllers, which have inherently noisy performance evaluations. This article discusses how the results and guidelines derived from tests on benchmark functions can be extended to the fitness distributions encountered in robotic learning. We show that the large-amplitude noise found in robotic evaluations is disruptive to the initial phases of the learning process of PSO. Under these conditions, neither increasing the population size nor increasing the number of iterations are efficient strategies to improve the performance of the learning. We also show that PSO is more sensitive to good spurious evaluations of bad solutions than bad evaluations of good solutions, i.e., there is a non-symmetric effect of noise on the performance of the learning.
Miniature Antennas and Arrays Embedded Within Magnetic Photonic Crystals

This letter presents the performance of small antennas embedded within a new class of magnetic photonic crystals (MPCs) constructed from periodic arrangements of homogenous and anisotropic material layers. Earlier studies of these crystals demonstrated that they exhibit slow modes within their propagation bands associated with minimal reflection at the air-crystal interface, drastic slow down of the group velocity and concurrent increase in the amplitude of the field within the crystal. In this letter, we take advantage of the latter to demonstrate the extraordinary high gain that small antennas exhibit when placed within the MPC. We also examine array configuration inside the MPC to enhance power reception and to further narrow the radiation pattern beam. An initial investigation on the effect of crystal thickness and material loss due to the MPC is also considered.
Optimizing nitrogen application rate and plant density for improving cotton yield and nitrogen use efficiency in the North China Plain

Plant population density (PPD) and nitrogen (N) application rate (NAR) are two controllable factors in cotton production. We conducted field experiments to investigate the effects of PPD, NAR and their interaction (PPD × NAR) on yield, N uptake and N use efficiency (NUE) of cotton using a split-plot design in the North China Plain during 2013 and 2014. The main plots were PPDs (plants m−2) of 3.00 (low), 5.25 (medium) and 7.50 (high) and the subplots were NARs of 0 (N-free), 112.5 (low), 225.0 (moderate) and 337.5 (high). During both 2013 and 2014, biological yield and N uptake of cotton increased significantly, but harvesting index decreased significantly with NAR and PPD increasing. With NAR increasing, internal nitrogen use efficiency(NUE) decreased significantly under three PPDs and agronomical NUE, physiologilal NUE, nitrogen recovery efficiency(NRE) and partial factor productivity from applied nitrogen (PFPN) also decreased significantly under high PPD between two years. Lint yield increment varied during different PPDs and years, but NAR enhancement showed less function under higher PPD than lower PPD in general. Taken together, moderate NAR under medium PPD combined higher lint yield with higher agronomic NUE, physiological NUE, and NRE, while low NAR with high PPD would achieve a comparable yield with superior NRE and PFPN and high NAR under high PPD and medium PPD produced higher biological yield but lower harvest index, lint yield and NUE compared to moderate NAR with medium PPD. Our overall results indicated that, in this region, increasing PPD and decreasing NAR properly would enhance both lint yield and NUE of cotton.
Pac-learning Recursive Logic Programs: Negative Results

In a companion paper it was shown that the class of constant-depth determinate k-ary recursive clauses is efficiently learnable. In this paper we present negative results showing that any natural generalization of this class is hard to learn in Valiant's model of pac-learnability. In particular, we show that the following program classes are cryptographically hard to learn: programs with an unbounded number of constant-depth linear recursive clauses; programs with one constant-depth determinate clause containing an unbounded number of recursive calls; and programs with one linear recursive clause of constant locality. These results immediately imply the non-learnability of any more general class of programs. We also show that learning a constant-depth determinate program with either two linear recursive clauses or one linear recursive clause and one non-recursive clause is as hard as learning boolean DNF. Together with positive results from the companion paper, these negative results establish a boundary of efficient learnability for recursive function-free clauses.
Confounding Equivalence in Causal Inference

Abstract The paper provides a simple test for deciding, from a given causal diagram, whether two sets of variables have the same bias-reducing potential under adjustment. The test requires that one of the following two conditions holds: either (1) both sets are admissible (i.e. satisfy the back-door criterion) or (2) the Markov boundaries surrounding the treatment variable are identical in both sets. We further extend the test to include treatment-dependent covariates by broadening the back-door criterion and establishing equivalence of adjustment under selection bias conditions. Applications to covariate selection and model testing are discussed.
VulMPFF: A Vulnerability Detection Method for Fusing Code Features in Multiple Perspectives

Source code vulnerabilities are one of the significant threats to software security. Existing deep learning-based detection methods have proven their effectiveness. However, most of them extract code information on a single intermediate representation of code (IRC), which often fails to extract multiple information hidden in the code fully, significantly limiting their performance. To address this problem, we propose VulMPFF, a vulnerability detection method that fuses code features under multiple perspectives. It extracts IRC from three perspectives: code sequence, lexical and syntactic relations, and graph structure to capture the vulnerability information in the code, which effectively realizes the complementary information of multiple IRCs and improves vulnerability detection performance. Specifically, VulMPFF extracts serialized abstract syntax tree as IRC from code sequence, lexical and syntactic relation perspective, and code property graph as IRC from graph structure perspective, and uses Bi-LSTM model with attention mechanism and graph neural network with attention mechanism to learn the code features from multiple perspectives and fuse them to detect the vulnerabilities in the code, respectively. We design a dual-attention mechanism to highlight critical code information for vulnerability triggering and better accomplish the vulnerability detection task. We evaluate our approach on three datasets. Experiments show that VulMPFF outperforms existing state-of-the-art vulnerability detection methods (i.e., Rats, FlawFinder, VulDeePecker, SySeVR, Devign, and Reveal) in Acc and F1 score, with improvements ranging from 14.71% to 145.78% and 152.08% to 344.77%, respectively. Meanwhile, experiments in the open-source project demonstrate that VulMPFF has the potential to detect vulnerabilities in real-world environments.
Natural wastewater treatment in Hungary.

Over the last few decades more and more natural wastewater treatment systems have been built in Hungary. The present study is the first step in creating a broad database on the water quality parameters and on the pollutant removal efficiency of these systems. The investigation included 78 plants out of which we analysed 16 systems in detail. Four types of natural methods are evaluated: wetlands, ponds, biomechanical combined oxidation (BMKO) systems, and poplar plantations. Pond systems are efficient in ammonium-nitrogen (NH4-N) removal, reducing it with 83% (41-88%). Their chemical oxygen demand (COD(Cr)) removal capacity is only 55% (37-81%). The only BMKO system that could be evaluated performs high COD(Cr) (77%) and total suspended solid (TSS) (89%) removal. Removal of NH4-N and total nitrogen (TN) declines during the years of operation giving an average value of 39% and 49%, respectively. The system is not efficient in phosphorus removal (13%). In wetlands the 71% COD(Cr) (53-96%), and 57% TSS (33-91%) removal provides satisfactory effluent quality most of the time. Wetlands performed low nutrient removal, i.e., 17% (-21-46%) for TN and 26% (-20-92%) for phosphorus. Poplar plantations are very effective in pollutant removal. Even the average removal of each nutrient type is above 75%. Several problems have occurred in the operation of natural treatment systems. However, if carefully planned and constructed, and the required maintenance work is done properly, they can be possible alternatives for wastewater treatment.
Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells

Modification of intestinal microbiota early in life by administration of probiotic bacteria may be a potential approach to prevent allergic disease. To select probiotic bacteria for in vivo purposes, we investigated the capacity of probiotic bacteria to interact with neonatal dendritic cells (DC) and studied the ensuing T cell polarizing effect. Immature DC were generated from cord blood‐derived monocytes and maturation was induced by maturation factors (MF), lipopolysaccharide (LPS) plus MF and Bifidobacterium bifidum, B. infantis, Lactobacillus salivarius, Lactococcus lactis alone or combined with MF. After 12 days of co‐culture with DC and Staphylococcus aureus enterotoxin B (SEB) as antigenic stimulus, cytokine production by autologous T cells was determined by intracellular cytokine staining. Additionally, cells were stimulated with CD3 and CD28 monoclonal antibodies and cytokines were measured in supernatants by multiplex assay. The probiotic strains induced partial maturation of DC. Full maturation of DC was induced for all strains tested when MF was added. The percentage of interleukin (IL)‐4 producing T cells was lower in T cell cultures stimulated with B. bifidum matured DC compared to MF and LPS matured DC, which coincided with a higher percentage of interferon (IFN)‐γ‐producing T cells. Furthermore, T cells stimulated by B. bifidum matured DC produced significantly more IL‐10 compared to MF matured DC. Selected species of the Bifidobacterium genus prime in vitro cultured neonatal DC to polarize T cell responses and may therefore be candidates to use in primary prevention of allergic diseases.
Erosion Based Visibility Preprocessing

This paper presents a novel method for computing visibility in 2.5D environments based on a novel theoretical result: the visibility from a region can be conservatively estimated by computing the visibility from a point using appropriately "shrunk" occluders and occludees. We show how approximate, yet conservative, shrunk objects can be efficiently computed in an urban environment. The technique provides a tighter potentially visible set (PVS) compared to the original method in which only occluders are shrunk. Finally, theoretical implications of the shrinking theorem are discussed, opening new research directions.
Sustained suppression in congruency tasks

In a list version of the Stroop task, Thomas (1977) observed that Stroop interference was smaller when the irrelevant word was repeated through parts of the list. MacLeod (1991) formulated the sustained-suppression hypothesis for this effect. It is assumed that the automatic response activation on the basis of the irrelevant word is selectively suppressed. In this paper this hypothesis is further investigated. In a serial Stroop task with short response–stimulus interval (RSI) we demonstrate that the Stroop effect disappears when the irrelevant word is repeated, whereas the Stroop effect is evident when the word changes. With a long RSI, there is no influence of the sequence of the irrelevant word. The same pattern of results is observed in a flanker task. The results are discussed in terms of the activation-suppression model (Ridderinkhof, 2002) and the sustained-suppression hypothesis.
Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays

The circadian clock in the mammalian hypothalamic suprachiasmatic nucleus (SCN) is entrained by the ambient light/dark cycle, which differentially acts to cause the clock to advance or delay. Light-induced changes in the rhythmic expression of SCN clock genes are believed to be a critical step in this process, but how the two entrainment modalities—advances vs. delays—engage the molecular clockwork remains incompletely understood. We investigated molecular substrates of photic entrainment of the clock in the SCN by stably entraining hamsters to T cycles (non–24-h light/dark cycles) consisting of a single 1-h light pulse repeated as either a short (23.33-h) or a long (24.67-h) cycle; under these conditions, the light pulse of the short cycle acts as “dawn,” whereas that of the long cycle acts as “dusk. ” Analyses of the expression of the photoinducible and rhythmic clock genes Period 1 and 2 (Per1 and Per2) in the SCN revealed fundamental differences under these two entrainment modes. Light at dawn advanced the clock, advancing the onset of the Per1 mRNA rhythm and acutely increasing mRNA transcription, whereas light at dusk delayed the clock, delaying the offset of the Per2 mRNA rhythm and tonically increasing mRNA stability. The results suggest that the underlying molecular mechanisms of circadian entrainment differ with morning (advancing) or evening (delaying) light exposure, and such differences may reflect how entrainment takes place in nocturnal animals under natural conditions.
The use of health related quality of life data to produce information sheets for patients with head and neck cancer.

INTRODUCTION Health related quality of life information gives patients and carers an indication of how they will be affected following treatment. Such knowledge can promote realistic expectations and help patients come to terms with their outcome. The aim of this paper is to describe the background development of patient information sheets produced at our unit. METHODS The data were compiled using a common head and neck cancer specific quality of life questionnaire (University of Washington Quality of Life [UW-QOL]). There are 12 domains comprising activity, appearance, anxiety, chewing, mood, pain, recreation, saliva, shoulder, speech, swallowing and taste. The data were collected over 19 years at our unit and focus on follow-up records at around 2 years as this gives a good indication of health related quality of life in survivorship. UW-QOL questionnaires were available from 1,511 patients treated following primary diagnosis of head and neck cancer, and there were 24 subgroups based on cancer site, stage and treatment. There were 2 other subgroups: 132 having transoral laser resection and 176 having laryngectomy. RESULTS The patient and carer research forum helped to design the information sheets, which display overall quality of life, percentages with 'good' outcome and 'significant problem' by domain, and the most important domains. Three examples are included in this paper: early stage oral cancer treated by surgery alone, early laryngeal cancer treated by surgery alone, and late stage oropharyngeal cancer treated by surgery and postoperative radiotherapy. All 26 subgroup information sheets are available in booklet form and on the internet. CONCLUSIONS How the surgical community best utilises this type of resource needs further research.
Asymmetric Lee distance codes for DNA-based storage

We consider a new family of asymmetric Lee codes that arise in the design and implementation of DNA-based storage systems and systems with parallel string transmission protocols. The codewords are defined over a quaternary alphabet, although the results carry over to other alphabet sizes, and have symbol distances dictated by their underlying binary representation. Our contributions are two-fold. First, we derive upper bounds on the size of the codes under the asymmetric Lee distance measure based on linear programming techniques. Second, we propose code constructions which imply lower bounds.
Molecular cloning and expression in Escherichia coli K‐12 of the rfb gene cluster determining the O antigen of an E. coli O111 strain

The O antigen of Escherichia coli O111 is identical in structure to that of Salmonella enterics serovar adelaide. Another O‐antigen structure, similar to that of E. coli O111 and S. enterica serovar adelaide is found in both E. coli O55 and S. enterica serovar greenside. Both O‐antigen structures contain colitose, a 3,6 dideoxyhexose found only rarely in the Enterobacteriaceae. The O‐antigen structure is determined by genes generally located in the rfb gene cluster. We cloned the rfb gene cluster from an E. coli O111 strain (M92), and the clone expressed O antigen in both E. coli K‐12 and a K‐12 strain deleted for rfb. Lipopoly‐saccharide analysis showed that the O antigen produced by strains containing the cloned DNA is polymerized. The chain length of O antigen was affected by a region outside of rfb but linked to it and present on some of the plasmids containing rfb. The rfb region of M92 was analysed and compared, by DNA hybridization, with that of strains with related O antigens. The possible evolution of the rfb genes in these O antigen groups is discussed.