Miracle-dz/UniFAR-FTUs huggingface dataset:
Reported school experiences of young people living with sickle cell disorder in England

A survey of 569 young people with sickle cell disorder (SCD) in England has found such pupils miss considerable periods of time from school, typically in short periods of two or three days. One in eight has school absences equating to government-defined ‘persistent absence’. Students with SCD report that they are not helped to catch up after these school absences. Half the children reported not being allowed to use the toilet when needed and not being allowed water in class; a third reported being made to take unsuitable exercise and being called lazy when tired. Children perceived both physical environment (temperature, school furniture) and social environment (being upset by teachers or other pupils) as triggers to episodes of their illness. Policy initiatives on school absences; preventive measures to ensure maintenance of good health; and measures to prevent perceived social attitudes precipitating ill health would also support children with other chronic illnesses at school.
Buprenorphine maintenance treatment of opiate dependence: a multicenter, randomized clinical trial.

AIMS To evaluate the safety and efficacy of an 8 mg/day sublingual dose of buprenorphine in the maintenance treatment of heroin addicts by comparison with a 1 mg/day dose over a 16-week treatment period. As a secondary objective, outcomes were determined concurrently for patients treated with two other dose levels. DESIGN Patients were randomized to four dosage groups and treated double-blind. SETTING Twelve outpatient opiate maintenance treatment centers throughout the United States. PARTICIPANTS Two hundred and thirty-nine women and 497 men who met the DSM-III-R criteria for opioid dependence and were seeking treatment. INTERVENTION Patients received either 1, 4, 8 or 16 mg/day of buprenorphine and were treated in the usual clinical context, including a 1-hour weekly clinical counseling session. MEASUREMENT Retention in treatment, illicit opioid use as determined by urine toxicology, opioid craving and global ratings by patient and staff. Safety outcome measures were provided by clinical monitoring and by analysis of the reported adverse events. FINDINGS Outcomes in the 8 mg group were significantly better than in the 1 mg group in all four efficacy domains. No deaths occurred in either group. The 8 mg group did not show an increase in the frequency of adverse events. Most reported adverse effects were those commonly seen in patients treated with opioids. CONCLUSIONS The findings support the safety and efficacy of buprenorphine and suggest that an adequate dose of buprenorphine will be a useful addition to pharmacotherapy.
Concentración y extranjerización del capital en la Argentina Reciente: ¿Mayor autonomía nacional o incremento de la dependencia?

El abandono del régimen de convertibilidad en 2002 implicó cambios sustantivos a nivel macroeconómico que tuvieron un fuerte impacto en el desempeño de los distintos sectores de la economía argentina. Sin embargo, durante la posconvertibilidad parece haberse registrado también cierta continuidad en determinados procesos económico-sociales: si bien desde los elencos gubernamentales se ha reivindicado sucesivamente la necesidad de recuperar un empresariado nacional fuerte, el peso del capital extranjero entre las empresas más grandes del país no ha disminuido. Esto es sumamente relevante teniendo en cuenta que la Argentina es una economía dependiente y, por lo tanto, el rol del capital transnacional en su proceso de acumulación es determinante. El objetivo del artículo es indagar sobre las continuidades y las rupturas en el proceso de extranjerización del gran capital en la Argentina a partir de un análisis de lo ocurrido con las quinientas empresas líderes de la economía durante el período 1993–2008.
Belief and Values in the Nuclear Debate1

A questionnaire was administered to 47 participants attending a workshop on nuclear energy shortly after publication of a report on a proposed nuclear fuel reprocessing plant. Supporters and opponents of the proposed development differed markedly in their estimates of its possible consequences, and of the relative importance of these consequences. They also differed in their endorsement of pro- and anti-nuclear lobbies, and the factors which they felt contributed most to the “quality of life”. Overall, pro-nuclear subjects appear to place emphasis on the economic benefits of nuclear energy, while anti-nuclear subjects appearad more concerned with social and political risks, and regraded alternative energy sources as more viable. It is concluded that an analysis of such attitudinal differences requires a consideration not only of differences in beliefs, but also of differences in belief salience.
Young Children's Exposure to Community Violence

Exposure to community violence can affect young children's development, even when the children are not direct victims of violence. This review explores the impact of community violence on young children, discusses some of the processes through which early development can be affected, and suggests the potential vulnerabilities of young children with developmental disabilities. Characteristics of young children's responses to stress and trauma are reviewed. Child, family, and community factors contributing to resilience are noted. Intervention approaches are described and suggestions offered for supporting children and families in order to reduce the negative impact of exposure to violence.
Brief Motivational Interventions for College Drinkers: What We Still Need to Know

Isolating the mechanisms of change that lead to reduced risk for heavy drinking by college students—a high-risk population—will permit development of succinct, targeted, and thereby more effective interventions. Examinations of currently used empirically supported brief interventions provide a starting point for identifying mediators (i.e., mechanisms) of change. Extrapolating from such work, it appears that there may be utility in using face-valid and possibly genderspecific interventions. In moving forward, it behooves clinical researchers to continue to draw on theory to identify potential proximal predictors of change. Continuing to think broadly will allow us to not only refine the current content of brief interventions but also open up the opportunity to introduce new components to treatment.
Characterization of airway mucus from a fatal case of status asthmaticus

We used density gradient methods to analyze mucus recovered from the airways of a patient who died from status asthmaticus. At postmortem the mucus that plugged the length of the bronchial tree could only be removed by cutting with forceps. It was dispersed in cesium bromide (CsBr) and examined in the analytical ultracentrifuge. Surprisingly, no macromolecular component was seen in the buoyant density region typical of mucus glycoprotein (at 1.5 g/ml). The gelatinous material migrated to the region of lowest density, typical of lipids, and thin‐layer chromatography indicated that besides neutral lipids, a variety of phospho‐ and glycolipids (including gangliosides) were present. The residue left after the lipid extraction contained all sugar components of mucus glycoprotein, and alkaline borohydride cleaved oligosaccharides three to 12 sugars long, indicating that the sugars were O‐glycosidically linked as in mucus glycoproteins. Prior desulfation of the residue increased the number of oligosaccharides released by borohydride; analysis showed the presence in these of components (glucose, methylmannuronate) not present in epithelial glycoprotein. A trace component of high buoyant density was also present: Glucose was the predominant component in this, but glycoprotein sugars were also present. The above results suggest that in status asthmaticus plugging of the airways with mucus can occur even in the absence of typical epithelial glycoprotein and that lipids play a crucial role in such plugging.
Surgical Outcomes of Forearm Loop Arteriovenous Fistula Formation Using Tapered versus Non-Tapered Polytetrafluoroethylene Grafts

Background Tapered grafts, which have a smaller diameter on the arterial side, have been increasingly used for arteriovenous fistula (AVF) formation. We compared the outcomes of 4–6-mm tapered and 6-mm straight forearm loop arteriovenous grafts. Methods A total of 103 patients receiving forearm loop arteriovenous grafts between March 2005 and March 2015 were retrospectively analyzed and separated into 2 groups (group A, 4- to 6-mm tapered grafts, n=78; group B, 6-mm straight grafts, n=25). In each group, complications and patency rates after surgery were assessed. Results Clinical characteristics and laboratory results, except for cerebrovascular disease history (group A, 7.7%; group B, 28.0%; p=0.014), were similar between the groups. No significant differences were found for individual complications. Kaplan-Meier survival analysis revealed no significant differences in 1-year, 3-year, and 5-year patency rates between groups (61.8%, 44.9%, and 38.5% vs. 62.7%, 41.1%, and 35.3%, respectively). Conclusion We found no significant differences in complication and patency rates between the tapered and straight graft groups. If there are no differences in complication and patency between the two graft types, tapered grafts may be a valuable option for AVF formation in light of their other advantages.
The Glycocalyx of the Human Umbilical Vein Endothelial Cell: An Impressive Structure Ex Vivo but Not in Culture

Potter and Damiano recently assessed the hydrodynamic dimensions of the endothelial glycocalyx in vivo (mouse cremaster muscle venules) and in vitro (human umbilical vein and bovine aorta endothelium cultured in perfused microchannels) using fluorescent microparticle image velocimetry (Circ Res. 2008;102:770–776). Great discrepancy was observed, the glycocalyx presenting a zone of interaction extending ≈0.52 &mgr;m into the vessel lumen in vivo, but only 0.02 to 0.03 &mgr;m from cultured cells. In an accompanying editorial, Barakat cautioned that the difference in hydrodynamic interaction did not allow one to conclude that the cultured cells totally lack a physical cell surface layer capable of mechanotransduction (Circ Res. 2008;102:747–748). To stabilize the glycocalyx for electron microscopic investigation, we perfusion-fixed 6 human umbilical veins and confluent and nonconfluent cultures (5 each) of human umbilical vein endothelial cells (HUVECs) with lanthanum/glutaraldehyde solution. Ex vivo, the thickness of glycocalyx of umbilical vein endothelium averaged 878 nm. HUVECs in vitro presented a glycocalyx with a dense-zone thickness of only 29.4 nm, plus sparse filaments reaching out on average to 118 nm, there being no difference between the nonconfluent and confluent cells. Immunohistology demonstrated the presence of heparan sulfates and syndecan-1, main constituents of the glycocalyx, both ex vivo and in vitro. These results support the observed discrepancy between glycocalyx thickness in vivo and in vitro, now for one and the same type of human cell. The presence of heparan sulfates and syndecan-1 also on cultured cells may explain why mechanotransduction phenomena can be observed even with a nonmature glycocalyx.
Analysis of Novel NEFL mRNA Targeting microRNAs in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motor neuron degeneration and neurofilament aggregate formation. Spinal motor neurons in ALS also show a selective suppression in the levels of low molecular weight neurofilament (NEFL) mRNA. We have been interested in investigating the role of microRNAs (miRNAs) in NEFL transcript stability. MiRNAs are small, 20–25 nucleotide, non-coding RNAs that act as post-transcriptional gene regulators by targeting the 3′ untranslated region (3′UTR) of mRNA resulting in mRNA decay or translational silencing. In this study, we characterized putative novel miRNAs from a small RNA library derived from control and sporadic ALS (sALS) spinal cords. We detected 80 putative novel miRNAs, 24 of which have miRNA response elements (MREs) within the NEFL mRNA 3′UTR. From this group, we determined by real-time PCR that 10 miRNAs were differentially expressed in sALS compared to controls. Functional analysis by reporter gene assay and relative quantitative RT-PCR showed that two novel miRNAs, miR-b1336 and miR-b2403, were downregulated in ALS spinal cord and that both stabilize NEFL mRNA. We confirmed the direct effect of these latter miRNAs using anit-miR-b1336 and anti-miR-b2403. These results demonstrate that the expression of two miRNAs (miRNAs miR-b1336 and miR-b2403) whose effect is to stabilize NEFL mRNA are down regulated in ALS, the net effect of which is predicted to contribute directly to the loss of NEFL steady state mRNA which is pathognomic of spinal motor neurons in ALS.
Real‐time Animation of Dressed Virtual Humans

In this paper, we describe a method for cloth animation in real‐time. The algorithm works in a hybrid manner exploiting the merits of both the physical‐based and geometric deformations. It makes use of predetermined conditions between the cloth and the body model, avoiding complex collision detection and physical deformations wherever possible. Garments are segmented into pieces that are simulated by various algorithms, depending on how they are laid on the body surface and whether they stick or flow on it. Tests show that the method is well suited to fully dressed virtual human models, achieving real‐time performance compared to ordinary cloth‐simulations.
Untreated ADHD in Adults

Objective: To analyze sex differences among adult, never-treated patients referred for central stimulant treatment of ADHD. Method: Data for 600 consecutive patients from northern Norway referred for evaluation by an expert team during 7 years were analyzed. General background information, diagnostic and social history, and symptom profiles were compared between previously never-treated men and women. Results: The sex ratio was skewed. Of the previously untreated patients, more than 20% fell outside society's ordinary vocational activities or social benefit system. Most patients had the combined form, one third the inattentive type, and only 2% the hyperactive/impulsive subtype. Abuse and criminality were more common among men, and affective, eating, and somatization disorders were more common among women. Otherwise few sex differences were found. Conclusion: AD/HD symptom intensity and subtypes did not differ between the sexes and was unrelated to age. Symptom intensity was linked with criminality, abuse, and other psychiatric problems, differentially for the two sexes. (J. of Att. Dis. 2009; 12(4) 353-360)
Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children

Rapid eye movement (REM) sleep has been shown to be related to many adaptive cognitive and behavioral functions. However, its precise functions are still elusive, particularly in developmental psychiatric disorders. The present study aims at investigating associations between polysomnographic (PSG) REM sleep measurements and neurobehavioral functions in children with common developmental psychiatric conditions compared to typically developing children (TDC). Twenty-four children with attention-deficit/hyperactivity disorder (ADHD), 21 with Tourette syndrome/tic disorder (TD), 21 with ADHD/TD comorbidity, and 22 TDC, matched for age and gender, underwent a two-night PSG, and their psychopathological scores and intelligence quotient (IQ) were assessed. Major PSG findings showed more REM sleep and shorter REM latency in the children with psychiatric disorders than in the TDC. Multiple regression analyses revealed that in groups with developmental psychopathology, REM sleep proportion correlated positively with scores of inattention and negatively with performance IQ. In contrast, in the group of TDC, REM sleep proportion correlated negatively with scores of inattention and positively with performance IQ. Whilst shorter REM latency was associated with greater inattention scores in children with psychopathology, no such an association existed in the group of TDC. Altogether, these results indicate an opposite impact of REM sleep on neurobehavioral functioning, related to presence or absence of developmental psychiatric disorders. Our findings suggest that during development, REM sleep functions may interact dissimilarly with different pathways of brain maturation.
Researching counterterrorism: a critical perspective from the field in the light of allegations and findings of covert activities by undercover police officers

The article addresses some of the key issues that are raised for researchers engaging with counterterrorism police officers and initiatives, when undertaking research. A significant area to explore in this context is, in fact, the issue of relationships with counterterrorism police officers who may themselves directly have been covert police officers in the past and/or who may be continuing in their current, apparently more open, role (wittingly or otherwise) as agents of broader state strategies of exploiting trust for intelligence-gathering purposes. This article suggests that it is important for researchers to understand that working within the counterterrorism field involves degrees and shades of risk in the service of trust-building, sensitivity and the empowerment of communities, and that researchers themselves can (wittingly and unwittingly) be part of wider strategies instigated by security-minded individuals or groups of counterterrorism police officers. Reflecting upon the research that we have undertaken individually and collectively over the last number of years, in the light of the most recent spate of allegations about counterterrorism police officers infiltrating activist and political protest groups, having sexual relationships, and indeed, on occasion, children, with women whilst undercover and of potentially working to entrap vulnerable individuals into planning terrorist acts, this article raises questions around trust, credibility, legitimacy, the prevalence and near unavoidability of dysfunctional agendas and the implications of all of the above for community-based approaches to counterterrorism.
Performance Evaluation of FPGA-Embedded Web Servers

Embedded web servers have a growing presence in a wide range of fields related to consumer electronics and industrial applications. FPGAs are a valid alternative in the implementation of these systems adding additional advantages to the traditional architectures based on microprocessors or microcontrollers. In this paper we introduce two web server implementations on FPGA devices. The first uses an embedded hard core microprocessor and the second is based on specifically designed hardware. The performance of these implementations has been evaluated and compared with commercial architectures. The results show that FPGA-based servers have a similar or superior throughput than other approaches but with reduced consumption of resources and low clock rates.
H∞ control for parameter uncertain T-S fuzzy systems with time-delay in state and control input

This paper focuses on the problem of H<sup>∞</sup> fuzzy control for a class of nonlinear uncertain delay systems in both state and control input through Takagi-Sugeno (T-S) fuzzy model approach. Sufficient conditions for the existence of H<sup>∞</sup> state feedback controller for the systems are presented on the basis of the linear matrix inequalities(LMIs) approach. Design example of robust H<sup>∞</sup> controller is given to illustrate the effectiveness of approaches proposed in this paper.
Developmental Theory-Driven Evaluation: Strategies for Course Development and Improvement.

This article focuses on the longitudinal evaluative strategies used in the development of a new teaching approach for a university course with high failure rates. The subject is compulsory for all first year engineering students at our university. The evaluation has been conducted as part of a process of developmental action research, and has focused on the cognitive and implementation theories represented in the course’s instructional approach. It has been based on qualitative focus group, interview and questionnaire analyses, and quantitative pre-experimental, predictive and quasi-experimental studies. The research has been conducted over a twenty five year period to validate the theory on which teaching has been based, to establish effects of the intervention and to identify ongoing needs for the type of instruction offered in the course. Based on improvement in both spatial ability and pass rates, the materials used in the course have been published in workbook form.
Validation of Consumer-Based Hip and Wrist Activity Monitors in Older Adults With Varied Ambulatory Abilities

Background: The accuracy of step detection in consumer-based wearable activity monitors in older adults with varied ambulatory abilities is not known. Methods: We assessed the validity of two hip-worn (Fitbit One and Omron HJ-112) and two wrist-worn (Fitbit Flex and Jawbone UP) activity monitors in 99 older adults of varying ambulatory abilities and also included the validity results from the ankle-worn StepWatch as a comparison device. Nonimpaired, impaired (Short Physical Performance Battery Score < 9), cane-using, or walker-using older adults (62 and older) ambulated at a self-selected pace for 100 m wearing all activity monitors simultaneously. The criterion measure was directly observed steps. Intraclass correlation coefficients (ICC), mean percent error and mean absolute percent error, equivalency, and Bland–Altman plots were used to assess accuracy. Results: Nonimpaired adults steps were underestimated by 4.4% for StepWatch (ICC = 0.87), 2.6% for Fitbit One (ICC = 0.80), 4.5% for Omron HJ-112 (ICC = 0.72), 26.9% for Fitbit Flex (ICC = 0.15), and 2.9% for Jawbone UP (ICC = 0.55). Impaired adults steps were underestimated by 3.5% for StepWatch (ICC = 0.91), 1.7% for Fitbit One (ICC = 0.96), 3.2% for Omron HJ-112 (ICC = 0.89), 16.3% for Fitbit Flex (ICC = 0.25), and 8.4% for Jawbone UP (ICC = 0.50). Cane-user and walker-user steps were underestimated by StepWatch by 1.8% (ICC = 0.98) and 1.3% (ICC = 0.99), respectively, where all other monitors underestimated steps by >11.5% (ICCs < 0.05). Conclusions: StepWatch, Omron HJ-112, Fitbit One, and Jawbone UP appeared accurate at measuring steps in older adults with nonimpaired and impaired ambulation during a self-paced walking test. StepWatch also appeared accurate at measuring steps in cane-users.
Gender, risk and finance: why can't a woman be more like a man?

Whilst acknowledging that the influence of gender upon women's business ownership is now included as a legitimate addition to the contemporary entrepreneurship research agenda, we question the assumptions which frame this inclusion. We argue that whilst the masculinity of the entrepreneurial discourse has been recognized, this has promoted an almost exclusive focus upon women as the cipher for and personification of the gendered subject. Using explorations of risk and business finance in the context of entrepreneurship, we demonstrate how this presumption ascribes women a discrete but generic theoretical and empirical status associated with weakness and lack. Drawing upon a feminist stance, we suggest that the framing of this contemporary critique, rather than addressing the gender blindness endemic within entrepreneurship, actually generates ontological biases and associated epistemological limitations which perpetuate female disadvantage. These, in turn, constrain the theoretical and empirical reach of the broader field of entrepreneurship research.