Miracle-dz/UniFAR-FTUs huggingface dataset:
Metamorphic Conditions of an Archean Core Complex in the Northern Wind River Range, Wyoming

The Archean granulite-facies rocks of the northern Wind River Range consist of extensive granitic orthogneisses and migtnatites hosting banded iron formations, amphibolites, metapelites, metabasites, ultramafites and quartzites. Quantitative pressure and temperature estimates from inclusions within garnet porphyroblasts are 815±5O°C and 8±1 kb using equilibria buffered by the assemblages spinel-quartz-garnet-sillimanite and garnet-rutile-ilmenite-sillimanite-quartz. Pressure-temperature estimates from the groundmass core assemblages of the banded iron formations and hornblende granulites are 750 ± 50 °C and 5-5 + 1 kb using garnet-clinopyroxene, garnet-orthopyroxene, and twopyroxene thermometry, and geobarometers based on the assemblages garnet-quartz-plagioclaseorthopyroxene and orthopyroxene-olivine-quartz. Rim compositions of the matrix minerals indicate nearly isobaric cooling from the conditions of 750 °C and 5-5 kb to < 600°C at 5 kb. Taken together, the P-T estimates from both the garnet inclusions and matrix assemblages are consistent with a clockwise P-T-t path for this terrane. Temperature estimates based on oxygen isotope thermometry in the banded iron formations vary systematically with the degree of visible late-stage deformation. There is no correlation between the isotopic temperature estimates and those from cation-based thermometers. The highest pressures and temperatures for the Wind River terrane are preserved by the inclusions in garnet porphyroblasts. The ability of these inclusions to preserve chemistries corresponding to higher pressures and temperatures is attributed to the combined effects of inclusion isolation and fixed inclusion volume within the garnet porphyroblasts. Cation-based thermometers in the groundmass preserve lower temperatures as a result of diffusional partial resetting. Isotopic thermometry will yield the lowest temperatures if there is even minor retrograde deformation. Geothermobarometry for the northern Wind River Archean terrane is consistent with a tectonic regime of doubly thickened crust. Peak metamorphic conditions preserved in the cores of the garnets are compatible with deep burial during the early stages of tectonism. Rapid to intermediate uplift due to erosion of the upper plate could explain the nearly isothermal decompression from 80 to 5-5 kb. The later, nearly isobaric, cooling path indicated by the rim compositions of the matrix minerals is consistent with relaxation of the elevated geotherm.
Factors Affecting Public Transport Use in Touristic Areas

The paper explores the underlying unobserved factors that influence transit ridership as well as the levels of satisfaction when using transit services of both tourists and residents in tourist areas in the peak summer period and in winter. The popular tourism destination of the Island of Kos in Greece was used as the case study for this research, while two appropriate statistical methods were employed, Factor Analysis and Ordered Probit models. According to the analysis, the most significant factor for the tourists when deciding to use public transport is service production, reflecting route frequencies and reliability of service. On the contrary, residents place more focus on qualitative aspects such as comfort, safety and information. Furthermore, a common factor that holds a high position in the preferences of both tourists and residents is transfer quality, comprising attributes related to transfer coordination. The paper presents in detail the results derived from the two analyses and discusses the use of these results by local authorities in order to adjust their policy plans accordingly and to define actions that can better tackle the residents and tourists’ needs and expectations.
SPREMLJANJE PRETOKA V MOŽGANSKIH ARTERIJAH S TCD TCD MONITORING OF CEREBRAL BLOOD FLOW Superkritični CO 2 , čistejša alternativa tradicionalnim metodam procesiranja polimernih biomaterialov Supercritical CO , a clean alternative to traditional methods of processing polymeric biomaterials

A wide variety of natural and synthetic polymers have applications in biomedical devices. They are usu-ally processed by melting or by using organic solvents, but these methods may affect the efficiency of incorpo-rating delicate bioactive compounds, such as drugs and proteins, during polymer processing. These short-comings can be avoided by using supercritical fluids as processing solvents or plasticizers. Supercritical carbon dioxide (scCO 2 ) has attracted attention for its potential as a plasticizer in polymer processing. It is used for obtaining microspheres, microcapsules, foams, membranes and polymer/drug composites. The method offers important advantages over other techniques, including the absence of harmful organic solvents, the mild processing conditions, and the ready control of particle and foam morphology simply by varying
The Effects of Progressive Resistance Strength Training on Pain, Mobility and Activities of Daily Living among Knee Osteoarthritis Patients: A randomized controlled trial

Purpose Knee osteoarthritis (OA) is a degenerative and weight-bearing joint disease that resulted from wear and tear of articular cartilage and its underlying bone. It is more common in overweight and obese knee OA patients. The purpose of this study was to investigate the effects of progressive resistance strength training of lower limb rehabilitation protocol (LLRP) on pain, activities of daily living (ADL) and mobility among knee OA patients who are overweight or obese. Methods Fifty-six overweight or obese knee OA patients were included and randomly assigned to a Rehabilitation Protocol Group (RPC) or Control Group (CG). The patients in the RPG performed the progressive resistance strength training of LLRP and followed the instructions of daily care (IDC) for duration of twelve weeks at home. The patients in the CG followed the IDC (conventional treatment) only. Outcome measures were assessed at baseline and after the interventions in both groups by comparing Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score for pain, Timed Up and Go (TUG) test score for mobility and Katz Index of Independence scores for ADL. Results The patients in the RPG reported significant improvements in WOMAC score for pain (p = 0.001), Katz Index of Independence scores for ADL (p = 0.003) and TUG test score for mobility (p = 0.004). The patients in the CG also reported significant improvements in WOMAC score for pain (p = 0.002) and ADL (p = 0.052), but not in mobility score (p = 0.065). The improvement in the pain and ADL scores was greater in the patients of RPG than the CG with p-value of 0.001 and 0.000 respectively. Conclusions The progressive resistance strength training of LLRP is effective in terms of reducing pain, improving mobility and ADL among knee OA patients who are overweight or obese.
Long term peatland subsidence: Experimental study and modeling scenarios in the Venice coastland

[1] Land subsidence in drained cultivated peatlands is responsible for a number of serious environmental concerns and economical problems at both the local and the global scale. In low-lying coastal areas it enhances the risk of flooding, the saltwater contamination of shallow aquifers, and the maintenance costs of the systems that help keep the farmland drained. Since the subsidence is a major consequence of the bio-oxidation of the soil organic fraction in the upper aerated zone, cropped peatlands in temperate and tropic regions are important sources of CO2 into the atmosphere. A 4-year long experimental study has been performed in a drained peatland located south of the Venice Lagoon, Italy, to help calibrate a land subsidence model developed to predict the expected behavior of the ground surface elevation. Continuous monitoring of the hydrological regime and land displacements shows that the vertical movement of the peat surface consists of the superimposition of daily/seasonal time-scale reversible deformations related to soil moisture, depth to the water table, and temperature fluctuations, and long term irreversible subsidence due to peat oxidation. A novel two-step modeling approach to separate the two contributions from the available observations is presented. First, the elastic component is computed by integrating the peat vertical deformations evaluated by a constitutive relationship describing the porosity variation with the moisture content and pore pressure changes implemented into a variably saturated flow equation-based numerical code. The observed trend is then filtered from the computed reversible displacement and is used to calibrate an empirical relationship relating land subsidence rate to drainage depth and soil temperature. The results show that in recent years the subsidence rate ranged from 3 to 15 mm a−1. The large variability is due to the different climate conditions underlying the monitoring period, in particular a wet 2002 and a very dry 2003. The model is then used to investigate the effect of human activities and climate change on the expected reduction of the peat thickness. The results suggest that the long term subsidence is mainly controlled by the manner in which the water table is managed in the peatland. For example, the subsidence rate is almost halved if the current 0.5 m mean water table depth is kept at 0.2 m. Conversely, even the extreme warning scenario provided by the IPCC in 2007 do not suggest significant changes on the expected subsidence trend, at least in low lying reclamation areas where the average temperature rise should not be accompanied by a significant reduction of water availability.
The global mismatch between equitable carbon dioxide removal liability and capacity

ABSTRACT Limiting climate change to 1.5°C and achieving net-zero emissions would entail substantial carbon dioxide removal (CDR) from the atmosphere by the mid-century, but how much CDR is needed at country level over time is unclear. The purpose of this paper is to provide a detailed description of when and how much CDR is required at country level in order to achieve 1.5°C and how much CDR countries can carry out domestically. We allocate global CDR pathways among 170 countries according to 6 equity principles and assess these allocations with respect to countries’ biophysical and geophysical capacity to deploy CDR. Allocating global CDR to countries based on these principles suggests that CDR will, on average, represent ∼4% of nations’ total emissions in 2030, rising to ∼17% in 2040. Moreover, equitable allocations of CDR, in many cases, exceed implied land and carbon storage capacities. We estimate ∼15% of countries (25) would have insufficient land to contribute an equitable share of global CDR, and ∼40% of countries (71) would have insufficient geological storage capacity. Unless more diverse CDR technologies are developed, the mismatch between CDR liabilities and land-based CDR capacities will lead to global demand for six GtCO2 carbon credits from 2020 to 2050. This demonstrates an imperative demand for international carbon trading of CDR.
Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study

Introduction: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk of infection, and hospital admission is occasionally required for surgical or daily conservative treatment. Therefore, the development of promising treatments that promote faster, uneventful healing is a must. Composed of cryoprecipitate and thrombin, fibrin glue has a history of surgical use for preventing bleeding and spinal fluid leakage. Moreover, in-house cryoprecipitates contain higher concentrations of coagulation factors and cytokines that may enhance wound healing than commercially available products. However, the efficacy of completely autologous fibrin glue (AFG) in tissue repair has not yet been fully demonstrated. Patient concerns: This study aimed to evaluate the efficacy of AFG in the treatment of refractory skin ulcers in comparison with the conventional treatment. Diagnosis: Two patients with skin ulcer on their lower extremities due to trauma or scleroderma who showed resistance to conventional treatment were included in the study. Both study participants were diagnosed with refractory skin ulcer and were ineligible for autologous skin transplantation. Interventions: AFG was prepared following autologous blood donation using a Cryoseal® system. Subsequently, AFG was administered to 50% of the area of each ulcer and observed for 4 weeks in comparison with recombinant basic fibroblast growth factor with bucladesine sodium treatment that was administered to the rest of the ulcer. Outcomes: The skin ulcer after trauma in participant 1 showed better improvement in the AFG-treated area. Although AFG did not show superiority regarding the ulcer area of a patient with scleroderma, it guarded the continuous exudation from the edge of the swollen skin surrounding the ulcer. Conclusion: AFG showed effective and beneficial results for wound healing of refractory skin ulcer and prevented exudation without any severe adverse events.
The impact of two dietary patterns on hyperuricemia in adults: A meta analysis of observational studies

Background: Hyperuricemia (HUA) is a crucial factor contributing to some chronic diseases among adults. In past observational literatures, scholars have debated the effectiveness of dietary pattern on HUA and inconsistencies exist. Given this condition, the study aimed to provide a comparative assessment of the relation between dietary pattern and HUA risk and offer implications to policy makers. Methods: A systematic research was undertaken in PubMed, Web of Science, Cochrane, Embase, Medicine, ScienceDirect and Medline to identify observational studies examining the effect of dietary pattern on HUA, and search period was from past to January 2022. Meta analysis was applied by using the Stata version 11.0 software. Results: A total of 34,583 adults from 8 observational studies, 45,525 adults from 6 observational studies were included to examine the effectiveness of “healthy” and “meat/western” dietary patterns on HUA risk respectively. The findings suggested that “healthy” dietary pattern significantly decreased the HUA risk (OR = 0.73; 95% CI: 0.61–0.88) both in Eastern countries (OR = 0.79; 95% CI: 0.64–0.98) and Western countries (OR = 0.53; 95% CI: 0.30–0.92) while the “Meat/Western” pattern increased the HUA possibilities (OR = 1.26; 95% CI: 1.17–1.37). Stratified analysis exhibited that “healthy” pattern reduced HUA risk in adults was more effective in cohort study (OR = 0.79; 95% CI: 0.72–0.86). Conclusions: This study’s findings highlighted the potential benefit of healthy dietary pattern in decreasing HUA risk. Accordingly, implementing policy makers of countries should enhance to appeal adults to keep a healthy diet, offer financial support to low-income staff, or provide guidelines for adult’s dietary behavior changes. Trial registration number: INPLASY: INPLASY202290034.
Boreal and Lusitanian species display trophic niche variation in temperate waters

Abstract Climate change has non‐linear impacts on species distributions and abundance that have cascading effects on ecosystem structure and function. Among them are shifts in trophic interactions within communities. Sites found at the interface between two or more biogeographical regions, where species with diverse thermal preferenda are assembled, are areas of strong interest to study the impact of climate change on communities' interactions. This study examined variation in trophic structure in the Celtic Sea, a temperate environment that hosts a mixture of cold‐affiliated Boreal species and warm‐affiliated Lusitanian species. Using carbon and nitrogen stable isotope ratios, trophic niche area, width, and position were investigated for 10 abundant and commercially important demersal fish species across space and time. In general, the niches of Boreal species appear to be contracting while those of Lusitanian species expand, although there are some fluctuations among species. These results provide evidence that trophic niches can undergo rapid modifications over short time periods (study duration: 2014–2021) and that this process may be conditioned by species thermal preferenda. Boreal species displayed spatial variation in trophic niche width and seem to be facing increased competition with Lusitanian species for food resources. These findings underscore the need to utilize indicators related to species trophic ecology to track the ecosystem alterations induced by climate change. Such indicators could reveal that the vulnerability of temperate ecosystems is currently being underestimated.
TMUB1 expression is associated with the prognosis of colon cancer and immune cell infiltration

Background TMUB1 is a transmembrane protein involved in biological signaling and plays an important role in the stability and transcription of P53. However, its role in tumor remains unknown. Methods Using R language, the expression level of 33 cancer spectrum TMUB1 was analyzed by the public database TCGA, GEO and HPA, the differential expressed gene (DEG) screening and protein interaction (PPI) network was constructed, and the differential genes of TMUB1 in colon cancer were identified. The relevant signaling pathways were identified by gene functional annotation and enrichment analysis. The ssGSEA algorithm in GSVA were used for immune infiltration analysis. The Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, nomogram and calibration map analysis were constructed to evaluate the correlation between TMUB1 expression and clinical prognosis. The expression levels of TMUB1 in intestinal cancer cell lines as well as in 10 intestinal cancer tissues were verified by qPCR experiments. Results Through the bioinformatics analysis of multiple databases and preliminary experimental studies, we found that the expression of TMUB1 was significantly increased in colon cancer tumors, and was correlated with the clinical N stage, pathological grade, lymphatic metastasis and BMI of colon cancer. TMUB1 may be involved in the regulation of the malignant progression of colon cancer. Meanwhile, patients with high expression of TMUB1 mRNA had worse OS and DSS, and TMUB1 expression was an independent prognostic factor for OS and DSS. It was further found that highly expressed TMUB1 tissues showed low levels of immune infiltration and stromal infiltration. Conclusion We reported the expression level of TMUB1 in colon cancer and analyzed its potential prognostic value in colon cancer through the bioinformatics analysis and preliminary experimental studies. The high expression of TMUB1 is a negative prognostic factor for colon cancer patients. TMUB1 may be a potential target for colon cancer.
Photodynamic toluidine blue-gold nanoconjugates as a novel therapeutic for Staphylococcal biofilms

Staphylococci are among the most frequent bacteria known to cause biofilm-related infections. Pathogenic biofilms represent a global healthcare challenge due to their high tolerance to antimicrobials. In this study, water soluble polyethylene glycol (PEG)-coated gold nanospheres (28 ppm) and nanostars (15 ppm) with electrostatically adsorbed photosensitizer (PS) Toluidine Blue O (TBO) ∼4 μM were successfully synthesized and characterized as PEG-GNPs@TBO and PEG-GNSs@TBO. Both nanoconjugates and the TBO 4 μM solution showed remarkable, if similar, antimicrobial photodynamic inactivation (aPDI) effects at 638 nm, inhibiting the formation of biofilms by two Staphylococcal strains: a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate and Staphylococcus epidermidis (S. epidermidis) RP62A. Alternatively in biofilm eradication treatments, the aPDI effects of PEG-GNSs@TBO were more effective and yielded a 75% and 50% reduction in viable count of MRSA and S. epidermidis RP62A preformed biofilms, respectively and when compared with untreated samples. This reduction in viable count was even greater than that obtained through aPDI treatment using a 40 μM TBO solution. Confocal laser microscopy (CLSM) and scanning electron microscope (SEM) images of PEG-GNSs@TBO's aPDI treatments revealed significant changes in the integrity and morphology of biofilms, with fewer colony masses. The generation of reactive oxygen species (ROS) upon PEG-GNSs@TBO's aPDI treatment was detected by CLSM using a specific ROS fluorescent probe, demonstrating bright fluorescence red spots across the surfaces of the treated biofilms. Our findings shine a light on the potential synergism between gold nanoparticles (AuNPs) and photosensitizers in developing novel nanoplatforms to target Staphylococcal biofilm related infections.
Big data analysis identified a telomere-related signature predicting the prognosis and drug sensitivity in lung adenocarcinoma

Telomeres exert a critical role in chromosome stability and aberrant regulation of telomerase may result in telomeres dysfunction and genomic instability, which are involved in the occurrence of cancers. However, limited studies have been performed to fully clarify the immune infiltration and clinical significance of telomeres-related genes (TRGs) in lung adenocarcinoma (LUAD). The number of clusters of LUAD was determined by consensus clustering analysis. The prognostic signature was constructed and verified using TCGA and GSE42127 dataset with Least Absolute Shrinkage and Selection Operator cox regression analysis. The correlation between different clusters and risk-score and drug therapy response was analyzed using TIDE and IMvigor210 dataset. Using several miRNA and lncRNA related databases, we constructed a lncRNA-miRNA-mRNA regulatory axis. We identified 2 telomeres-related clusters in LUAD, which had distinct differences in prognostic stratification, TMB score, TIDE score, immune characteristics and signal pathways and biological effects. A prognostic model was developed based on 21 TRGs, which had a better performance in risk stratification and prognosis prediction compared with other established models. TRGs-based risk score could serve as an independent risk factor for LUAD. Survival prediction nomogram was also developed to promote the clinical use of TRGs risk score. Moreover, LUAD patients with high risk score had a high TMB score, low TIDE score and IC50 value of common drugs, suggesting that high risk score group might benefit from receiving immunotherapy, chemotherapy and target therapy. We also developed a lncRNA KCNQ1QT1/miR-296-5p/PLK1 regulatory axis. Our study identified 2 telomeres-related clusters and a prognostic model in LUAD, which could be helpful for risk stratification, prognosis prediction and treatment approach selection.