Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the clinical learning experience : voices of Malawian undergraduate student nurses

Very little has been done to define the process of clinical learning in Malawi and yet anecdotal observations reveal that it is more challenging than classroom teaching and learning. This set the impetus for this hermeneutic phenomenological study, the aim being to gain an understanding of the nature of the clinical learning experience for undergraduate students in Malawi and to examine their clinical experiences against some experiential learning models (Kolb 1984; Jarvis et al 1998). The study setting was Kamuzu College of Nursing (KCN) and the sample was selected purposively and consisted of 30 undergraduate students who were recruited through volunteering. Conversational interviews were conducted to obtain students’ accounts of their clinical learning experience and an eclectic framework guided the phenomenological analysis. The study raises issues which relate to nursing education and nursing practice in Malawi. From an experiential learning perspective, the study reveals that clinical learning for KCN students is largely non-reflective. The study primarily reveals that the clinical learning experience is enormously challenging and stressful due to structural problems prevalent in the clinical learning environment (CLE). In some clinical settings the CLE appears hostile and oppressive due to negative attitudes which some of the clinical staff display towards KCN students. Consequently, students’ accounts depict emotionally charged situations which confront them and this illustrates that clinical learning for KCN students is an experience suffused with emotions. In literature issues on emotions are commonly discussed under emotional labour (Hochschild 1983) and I used the concept as a basis for my pre-understandings and interpreted the students’ accounts of their clinical learning experience against such a conceptual framework. What resonated from their narratives was the depth of the emotion work they engage in. This enabled me to arrive at a new and unique conceptualisation of clinical learning redefined in terms of emotional labour within the perspective of nurse learning in Africa. The findings are a unique contribution to the literature on emotions and provide essential feedback which forms the basis for improving clinical learning in Malawi.
Revisiting beta thalassemia intermedia: past, present, and future prospects

ABSTRACT Background: The spectrum of thalassemias is wide ranging from thalassemia minor, which consists of mild hypochromic microcytic anemia without obvious clinical manifestations, to thalassemia major (TM), which is characterized by severe anemia since the first years of life and is transfusion dependent. Thalassemia intermedia (TI) describes those patients with mild or moderate anemia. Objective: To describe the genetic features and major clinical complications of TI, and the therapeutic approaches available in the management of this disease. Methods: Publications from potentially relevant journals were searched on Medline. Results and discussion: Over the past decade, the understanding of TI has increased with regard to pathophysiology and molecular studies. It is now clear that clinical presentation and specific complications make TI different from TM. It is associated with greater morbidity, a wider spectrum of organ dysfunction and more complications than previously thought. Conclusion: TI is not a mild disease. The interplay of three hallmark pathophysiologic factors (ineffective erythropoiesis, chronic anemia, and iron overload) leads to the clinical presentations seen in TI. New treatment modalities are currently being investigated to broaden the options available for TI management.
Parsing with Pictures

The development of elegant and practical algorithms for parsing context-free languages is one of the major accomplishments of 20 century Computer Science. These algorithms are presented in the literature using string rewriting systems or abstract machines like pushdown automata, but the resulting descriptions are unsatisfactory for several reasons. First, even a basic understanding of parsing algorithms for some grammar classes such as LR(k) grammars requires mastering a formidable number of difficult concepts and terminology. Second, parsing algorithms for different grammar classes are often presented using entirely different formalisms, so the relationships between these grammar classes are obscured. Finally, these algorithms seem unrelated to algorithms for regular language recognition even though regular languages are a subset of context-free languages. In this paper, we show that these problems are avoided if parsing is reformulated as the problem of finding certain kinds of paths in a graph called the Grammar Flow Graph (GFG) that is easily constructed from a context-free grammar. Intuitively, GFG’s permit parsing problems for context-free grammars to be formulated as path problems in graphs in the same way that non-deterministic finite-state automata do for regular grammars. We show that the GFG enables a unified treatment of Earley’s parser for general context-free grammars, recursive-descent parsers for LL(k) and SLL(k) grammars, and shift-reduce parsers for LR(k) and SLR(k) grammars. Computation of look-ahead sets becomes a simple interprocedural dataflow analysis. These results suggest that the GFG can be a new foundation for the study of context-free languages.
The Sentinel-3 Mission: Overview and status

The series of Global Monitoring for Environment and Security (GMES) Sentinel satellites will continue and extend the European heritage of ENVISAT to provide data to numerous user communities. Sentinel-3 is being developed to support GMES Ocean and global Land monitoring services. Two Sentinel-3 satellites are in development with a first launch in 2014 and the second satellite expected approximately 18 months after the first. This paper provides an overview of the Sentinel-3 Mission.
Development of Smartphone Applications for Nutrition and Physical Activity Behavior Change

Background Young adults (aged 18 to 35) are a population group at high risk for weight gain, yet we know little about how to intervene in this group. Easy access to treatment and support with self-monitoring of their behaviors may be important. Smartphones are gaining in popularity with this population group and software applications (“apps”) used on these mobile devices are a novel technology that can be used to deliver brief health behavior change interventions directly to individuals en masse, with potentially favorable cost-utility. However, existing apps for modifying nutrition or physical activity behaviors may not always reflect best practice guidelines for weight management. Objective This paper describes the process of developing four apps aimed at modifying key lifestyle behaviors associated with weight gain during young adulthood, including physical activity, and consumption of take-out foods (fast food), fruit and vegetables, and sugar-sweetened drinks. Methods The development process involved: (1) deciding on the behavior change strategies, relevant guidelines, graphic design, and potential data collection; (2) selecting the platform (Web-based versus native); (3) creating the design, which required decisions about the user interface, architecture of the relational database, and programming code; and (4) testing the prototype versions with the target audience (young adults aged 18 to 35). Results The four apps took 18 months to develop, involving the fields of marketing, nutrition and dietetics, physical activity, and information technology. Ten subjects provided qualitative feedback about using the apps. The slow running speed of the apps (due to a reliance on an active Internet connection) was the primary issue identified by this group, as well as the requirement to log in to the apps. Conclusions Smartphone apps may be an innovative medium for delivering individual health behavior change intervention en masse, but researchers must give consideration to the target population, available technologies, existing commercial apps, and the possibility that their use will be irregular and short-lived.
Social networks in the guppy (Poecilia reticulata)

Social network theory is used to elicit details of the social structure of a population of free–ranging guppies, Poecilia reticulata. They were found to have a complex and highly structured social network, which exhibited characteristics consistent with the ‘small world’ phenomenon. Stable partner associations between individuals were observed, a finding that fulfils the basic prerequisite for the evolution of reciprocal altruism. The findings are discussed in relation to the ecology and evolution of the wild population, highlighting the potential application of network theory to social associations in animals.
Closed-Form Formulae for Time-Difference-of-Arrival Estimation

For a positioning system with L sensors, a maximum of L(L-1)/2 distinct time-difference-of-arrival (TDOA) measurements, which are referred to as the full TDOA set, can be obtained. In this paper, closed-form expressions regarding optimum conversion of the full TDOA set to the nonredundant TDOA set, which corresponds to (L-1) TDOA measurements with respect to a common reference receiver, in the case of white signal source and noise, are derived. The most interesting finding is that optimum conversion can be achieved via the standard least squares estimation procedure. Furthermore, the Cramer-Rao lower bound for TDOA-based positioning is produced in closed-form, which will be useful for optimum sensor array design.
The shaping of tourist experience: the importance of stories and themes

Introduction: Stories are such a common part of our lives that it is sometimes easy to overlook their central role in the way we communicate with each other, understand and make sense of the world and its events, and store our memories. The importance of stories as a core element in human cognition and social interaction has long been recognised by psychologists (Schank & Abelson, 1977), sociologists (Durkheim et al., 1995) and anthropologists (Holloway, 1997). In tourism research, however, much of the existing focus has been on narratives in general with only a few researchers explicitly analysing tourist stories (Hsu et al., 2009). This chapter argues that stories and themes are critical elements in understanding tourist experiences and that we need to develop integrative conceptual frameworks in order to better understand the nature of tourist experiences. The overall aim of the chapter is to integrate concepts and issues from research into both the role of stories and themes in tourism and factors contributing to positive tourist evaluations, in order to improve our understanding of tourist experiences. The chapter will follow an approach suggested by Fournier (1998) for understanding brand relationships in marketing and Gorke (2001) for analysing entertainment as public communication. After defining key terms, this chapter will identify major themes and concepts in existing research into stories and themes in tourism and major findings from, and theoretical approaches to, research,into tourist experiences. The chapter will then highlight the convergence between these two areas before suggesting how stories and themes might fit within a systems model of the tourist experience. This systems model will then be used to highlight areas for further research as well as suggesting some practical implications.
FoV-Clustering as a solution to a novel camera node activation problem in WVSNs

In Wireless Visual Sensor Networks (WVSNs), node selection and organization to realize applications is the title of some research fields known as network topology models that can be classified into two main categories of single-tier and multi-tier. According to the literature, only multi-tier topology model is able to provide a balance between WVSNs objectives such as low cost, maximum coverage, minimum energy consumption, high functionality, and good reliability. In a general architecture for this model, the lowest tier consists of scalar nodes that can activate camera nodes of upper tier only if necessary. However, regarding the inter-tier communication radio range and camera nodes' covered area, in many cases the activated cameras do not detect any objects. The mentioned problem which wastes energy and processor time for doing unneeded image capturing and object detection operations is introduced for the first time in this paper. Besides, a new clustering method with the aim of determining the scalar nodes located inside the area covered by a camera node is proposed as a solution. As the simulation results indicate, this solution has succeeded in saving camera nodes' energy and prolonging network lifetime.
Children with Imprisoned Parents

This report is based on a comparative study of the experiences of children with imprisoned parents in Denmark, Italy, Poland and Northern Ireland. It is based on primary research. Chapter 5 is on the experience of prisoners children's in Northern Ireland. The editors of the report are Peter Scharff-Smith and Lucy Gampell.
Recombinant human growth hormone in the treatment of Turner syndrome

Turner syndrome (TS) is a common chromosomal disorder in women that is associated with the absence of one of the X chromosomes. Severe short stature and a lack of pubertal development characterize TS girls, causing psychosocial problems and reduced bone mass. The growth impairment in TS seems to be due to multiple factors including an abnormal growth hormone (GH) – insulin-like growth factor (IGF) – IGF binding protein axis and haploinsufficiency of the short stature homeobox-containing gene. Growth hormone and sex steroid replacement therapy has enhanced growth, pubertal development, bone mass, and the quality of life of TS girls. Recombinant human GH (hGH) has improved the height potential of TS girls with varied results though, depending upon the dose of hGH and the age of induction of puberty. The best final adult height and peak bone mass achievement results seem to be achieved when hGH therapy is started early and puberty is induced at the normal age of puberty in a regimen mimicking physiologic puberty. The initiation of estradiol therapy at an age-appropriate time may also help the TS patients avoid osteoporosis during adulthood. Recombinant hGH therapy in TS seems to be safe. Studies so far show no adverse effects on cardiac function, glucose metabolism or any association with neoplasms but research is still in progress to provide conclusive data on long-term safety.
Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate.

The three-dimensional structures of Escherichia coli glycerol kinase (GK) with bound glycerol in the presence and absence of one of the allosteric regulators of its activity, fructose 1,6-bisphosphate (FBP), at 3.2 and 3.0 A, are presented. The molecule crystallized in space group P41212, and the structure was solved by molecular replacement. The models were refined with good stereochemistry to final R-factors of 21.1 and 21.9%, respectively. A tetrameric arrangement of monomers was observed which was essentially identical to the proposed inactive tetramer II previously described [Feese, M. D. , Faber, H. R. , Bystrom, C. E. , Pettigrew, D. W. , and Remington, S. J. (1998) Structure (in press)]. However, the crystal packing in this form was especially open, permitting the FBP binding site to be occupied and identified. The crystallographic data revealed a most unusual type of FBP binding site formed between two glycine-arginine loops (residues 234-236) where one-half of the binding site is donated by each monomer at the regulatory interface. The molecule of FBP binds in two mutually exclusive modes on a noncrystallographic 2-fold axis at 50% occupancy each; thus, a tetramer of GK binds two molecules of FBP. Ionic interactions between the 1- and 6-phosphates of FBP and Arg 236 were observed in addition to hydrogen bonding interactions between the backbone amide of Gly 234 and the 6-phosphate. No contacts between the protein and the furanose ring were observed. Mutagenesis of Arg 236 to alanine drastically reduced the extent of inhibition of GK by FBP and lowered, but did not eliminate, the ability of FBP to promote tetramer association. These observations are consistent with the previously characterized mechanism of FBP inhibition of GK, in which FBP acts both to promote dimer-tetramer assembly and to inactivate the tetramers.
Multilevel full-chip gridless routing considering optical proximity correction

To handle modern routing with nanometer effects, we need to consider designs of variable wire widths and spacings, for which gridless routers are desirable due to their great flexibility. The gridless routing is much more difficult than the grid-based one because the solution space of gridless routing is significantly larger than that of grid-based one. In this paper, we present the first multilevel, full-chip gridless detailed router. The router integrates global routing, detailed routing, and congestion estimation together at each level of the multilevel routing. It can handle non-uniform wire widths and consider routability and optical proximity correction (OPC). Experimental results show that our approach obtains significantly better routing solutions than previous works. For example, for a set of 11 commonly used benchmark circuits, our approach achieves 100% routing completion for all circuits while the famous state-of-the-art three-level routing and multilevel routing (multilevel global routing + flat detailed routing) cannot complete routing for any of the circuits. Besides, experimental results show that our multilevel gridless router can handle non-uniform wire widths efficiently and effectively (still maintain 100% routing completion for all circuits). In particular, our OPC-aware multilevel gridless router archives an average reduction of 11.3% pattern features and still maintains 100% routability for the 11 benchmark circuits.
Pteropine orthoreovirus infection among out‐patients with acute upper respiratory tract infection in Malaysia

This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyngeal swabs, our study demonstrates that PRV is among one of the common causative agents of acute URTI with cough and sore throat as the commonest presenting clinical features. Phylogenetic analysis on partial major outer and inner capsid proteins shows that these PRV strains are closely related to Melaka and Kampar viruses previously isolated in Malaysia. Further study is required to determine the public health significance of PRV infection in Southeast Asia, especially in cases where co‐infection with other pathogens may potentially lead to different clinical outcomes. J. Med. Virol. 87:2149–2153, 2015. © 2015 Wiley Periodicals, Inc.
Factors affecting teachers' use of information and communications technology: a review of the literature

This article reports on the literature associated with practising teachers' uptake of information and communications technology (ICT). Studies reveal a number of factors which influence teachers' decisions to use ICT in the classroom: access to resources, quality of software and hardware, ease of use, incentives to change, support and collegiality in their school, school and national polices, commitment to professional learning and background in formal computer training. The review highlights the role of pedagogy and suggests that teachers' beliefs about teaching and learning with ICT are central to integration. It is suggested that successful implementation of ICT needs to address three interlocking frameworks for change: the teacher, the school and policy makers.
Cardiac surgery in octogenarians; peri-operative outcome and long-term results.

AIMS Because the elderly are increasingly referred for operation, we reviewed the results of cardiac surgery in patients of 80 years or older. METHODS AND RESULTS Records of 182 consecutive octogenarians who had had cardiac operations between 1992 and 1998 were reviewed. Follow-up was 100% complete. Seventy patients had coronary grafting (CABG), 70 aortic valve replacement, 30 aortic valve replacement+CABG, and 12 mitral valve repair/replacement. Rates of hospital death, stroke, and prolonged stay (>14 days) were as follows: CABG: 7 (10%), 2 (2.8%) and 41 (58%); aortic valve replacement: 6 (8.5%), 2 (2.8%) and 32 (45.7%); aortic valve replacement+CABG: 8 (26.5%), 1 (3.8%) and 14 (46.6%); mitral valve repair/replacement: 3 (25%), 1 (8.3%) and 5 (41.6%). Multivariate predictors (P<0.05) of hospital death were New York Heart Association functional class, urgent procedure, prolonged cardiopulmonary bypass time, and, after aortic valve replacement, previous percutaneous aortic valvuloplasty. Ascending aortic atheromatous disease was predictive of stroke, while pre-operative myocardial infarction was predictive of prolonged hospital stay. Actuarial 5-year survival was as follows: CABG, 65.8+/-8.8%; aortic valve replacement, 63.6+/-7.1%; aortic valve replacement+CABG, 62.4+/-6.8%; mitral valve repair/replacement, 57.1+/-5.6%; and total, 63.0+/-5.6%. Multivariate predictors of late death were pre-operative myocardial infarction, and urgent procedure. Ninety percent of long-term survivors were in New York Heart Association class I or II, and 87% believed having a heart operation after age 80 years was a good choice. CONCLUSION Cardiac operations are successful in most octogenarians with increased hospital mortality, and longer hospital stay. Long-term survival and quality of life are good.
Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior. Both increased and decreased aggression in the cocaine-treated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively. The current study was an effort to determine whether the effect of gestational cocaine on maternal aggression is transient or would continue into the postpartum period; whether an intermittent cocaine treatment regimen, which incorporates gestational and postpartum intermittent cocaine treatment, would differ from chronic daily gestational treatment; and finally, whether next generation female offspring of cocaine-treated or control dams would have altered MA behavior and oxytocin system changes attributable to either prenatal drug exposure, rearing condition or both. We now report no increase in maternal aggression following chronic gestational treatment and significantly lower levels of aggression in intermittently treated dams on postpartum day eight, with no significant effects in either group on postpartum day 12.Young adult female offspring of the cocaine-treated and control dams, who reared their own natural litters and were tested on postpartum day eight for maternal aggression, had higher levels of maternal aggression towards an intruder attributable to both prenatal cocaine exposure and rearing condition. Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes.