Miracle-dz/UniFAR-FTUs huggingface dataset:
Silk fibroins modify the atmospheric low temperature plasma-treated poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) film for the application of cardiovascular tissue engineering

Tissue engineered scaffold is one of the hopeful therapies for the patients with organ or tissue damages. The key element for a tissue engineered scaffold material is high biocompatibility. Herein the poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) film was irradiated by the low temperature atmospheric plasma and then coated by the silk fibroins (SF). After plasma treatment, the surface of PHBHHx film became rougher and more hydrophilic than that of original film. The experiment of PHBHHx flushed by phosphate buffer solution (PBS) proves that the coated SF shows stronger immobilization on the plasma-treated film than that on the untreated film. The cell viability assay demonstrates that SF-coated PHBHHx films treated by the plasma significantly supports the proliferation and growth of the human smooth muscle cells (HSMCs). Furthermore, the scanning electron microscopy and hemotoylin and eosin (HE) staining show that HSMCs formed a cell sub-monolayer and secreted a large amount of extracellular matrix (ECM) on the films after one week's culture. The silk fibroins modify the plasma-treated PHBHHx film, providing a material potentially applicable in the cardiovascular tissue engi-neering.
The Other Side of Cognitive Control: Can a Lack of Cognitive Control Benefit Language and Cognition?

Cognitive control refers to the regulation of mental activity to support flexible cognition across different domains. Cragg and Nation (2010) propose that the development of cognitive control in children parallels the development of language abilities, particularly inner speech. We suggest that children's late development of cognitive control also mirrors their limited ability to revise misinterpretations of sentence meaning. Moreover, we argue that for certain tasks, a tradeoff between bottom-up (data-driven) and top-down (rule-based) thinking may actually benefit performance in both children and adults. Specifically, we propose that a lack of cognitive control may promote important aspects of cognitive development, like language acquisition and creativity.
Martensitic Transformation Characteristic of Ni-Mn Based Ferromagnetic Shape Memory Alloys

Ferromagnetic shape memory alloys emerge as new functional materials which have interesting magnetomechanical coupling effects such as the ferromagnetic shape memory effect. These types of materials significantly change their shape and dimensions under the application of external fields i.e. either by using thermal energy or magnetic energy. Among them, some are the magnetostrictive alloys which in turn can change their shape by magnetic field up to 0.1 percent and by mechanical stress up to 10 percent in martensitic state. Up to 6 percent deformation can be obtained in materials under the action of the magnetic field which undergo the thermoelastic transformation into ferromagnetic phase. Due to higher processing cost and costly elements for alloying, ferromagnetic shape memory alloy have not so broadly utilization and satisfactorily use. Among different type of Ni-Mn based Heusler ferromagnetic shape memory alloys, Ni-Mn-Sn alloy have potential properties and exhibits lower cost. In this paper martensitic transformation of Ni 50 Mn 50-y Sn y (y= 5, 10, 12.5) alloys were investigated. By differential scanning calorimetric measurement, it has been observed that, by keeping one element i.e. Ni as constant weight percentage, if we increase the weight percent of Sn; then martensitic starting temperature as well as austenitic starting temperature gradually decreases.
PTK7 recruits dsh to regulate neural crest migration

PTK7 regulates planar cell polarity (PCP) signaling during vertebrate neural tube closure and establishment of inner ear hair cell polarity; however, its signaling mechanism is unknown. Here, we demonstrate a new function for PTK7 in Xenopus neural crest migration and use this system in combination with in vitro assays to define the intersection of PTK7 with the non-canonical Wnt signaling pathway that regulates PCP. In vitro, using Xenopus ectodermal explants, we show that PTK7 recruits dishevelled (dsh) to the plasma membrane, a function that is dependent on the PDZ domain of dsh, as well as on the conserved kinase domain of PTK7. Furthermore, endogenous PTK7 is required for frizzled7-mediated dsh localization. Immunoprecipitation experiments confirm that PTK7 can be found in a complex with dsh and frizzled7, suggesting that it cooperates with frizzled to localize dsh. To evaluate the in vivo relevance of the PTK7-mediated dsh localization, we analyzed Xenopus neural crest migration, as loss-of-function of PTK7 inhibits neural crest migration in whole embryos as well as in transplanted neural crest cells. Supporting the in vivo role of PTK7 in the localization of dsh, a PTK7 deletion construct deficient in dsh binding inhibits neural crest migration. Furthermore, the PTK7-mediated membrane localization of a dsh deletion mutant lacking PCP activity inhibits neural crest migration. Thus, PTK7 regulates neural crest migration by recruiting dsh, providing molecular evidence of how PTK7 intersects with the PCP signaling pathway to regulate vertebrate cell movements.
Pharmacokinetics of ceftazidime in newborn infants

Doses of 50 mg of ceftazidime per kg were administered intravenously to 29 newborn infants every 8 or 12 h for 3 to 5 days. Mean peak concentrations in plasma ranged from 102 to 124 micrograms/ml. Mean elimination half-life values ranged from 2.9 to 6.7 h and varied inversely with gestational age and plasma clearances. Peak and trough plasma bactericidal titers against an Escherichia coli and a group B streptococcus strain were at least 1:16 and 1:32, respectively.
Validating IGE Mode of Block Cipher from Quantum Adversaries

The Telegram which is a very popular messenger uses a special mode called IGE(Infinite Garble Extension). IGE mode is not included in standard mode of operation recommended by National Institute of Standards and Technology(NIST) in 2001. Block cipher encrypts fixed length of plaintext into the corresponding fixed-length of ciphertext using a secret key shared by two parties and utilizes lots of mode of operation for various length of plaintext. Even though Telegram uses non-standard IGE mode, Telegram is claimed to be secure and demonstrate their security is stronger than other IM’s. Thus, we need to verify the security of IGE mode depending on underlying block ciphers. In this paper, we show that IGE mode block cipher used in Telegram assuming sPRF is not IND-qCPA, but assuming qPRF is IND-qCPA.
Vero cytotoxin-producing Escherichia coli, particularly serogroup O 157, associated with human infections in the United Kingdom: 1989–91

This survey reports the results of investigations performed by the Laboratory of Enteric Pathogens (LEP), to identify evidence of human infection with Vero cytotoxin-producing Escherichia coli (VTEC) in the UK during the period 1989–91. Bacterial isolates, faecal specimens and serum samples were received from patients suffering from diarrhoea, bloody diarrhoea and haemolytic uraemic syndrome. Using serotyping, Vero cytotoxin gene probing and an ELISA for serum antibodies to E. coli 0 157, evidence of infection was detected in 232, 428 and 615 individuals in 1989. 1990 and 1991 respectively. Of these individuals, 15% were reported as having HUS. Vero cytotoxin-producing E. coli O 157 was the most frequently encountered serogroup. with isolations from a total of 1092 individuals over the 3-year period. The incidence of VTEC infection increased from 0·41/ 100000 in 1989 to 1· 07/100000 in 1991. The area with the highest rate of infection in each year was Scotland, increasing from 1–37/100000 in 1989 to 3·97/ 100000 in 1991.
Issues in Informing Science and Information Technology Performance Analysis of Double Buffer Technique ( DBT ) Model for Mobility Support in Wireless IP Networks

Existing mobility support models in cellular communications misinterpret mobility loss in cellular networks as congestion loss, thus it degrades the performance by invoking unnecessary congestion control action. In this paper, we investigated the performance of Double Buffer Technique (DBT) model for mobility support in wireless IP networks. The DBT model uses the END message and the TQRS timer to maintain the packet sequence and decrease the load on the new foreign agent when the timer expires, respectively. Also, the protocol showed improved performance degradation caused by the handover of the mobile terminal. In order to demonstrate the superiority of our scheme over the existing ones, we used the following performance metrics: packet out-of-sequence, cell loss ratio, bandwidth overhead, and suitability for real-time services. The numerical results obtained revealed that the buffer size, the waiting time, and the packet loss probabilities in the model were suitable to the wireless IP environment.
Structural and Machine Design Using Piezoceramic Materials: A Guide for Structural Design Engineers

Using piezoceramic materials is one way the design engineer can create structures which have an ability to both sense and respond to their environment. Piezoceramic materials can be used to create structural sensors and structural actuators. Because piezoceramic materials have transduction as a material property, their sensing or actuation functions are a result of what happens to the material. This is different than discrete devices we might attach to the structure. For example, attaching an accelerometer to a structure will yield an electrical signal proportional to the acceleration at the attachment point on the structure. Using a electromagnetic shaker as an actuator will create an applied force at the attachment point. Active material elements in a structural design are not easily modeled as providing transduction at a point, but rather they change the physics of the structure in the areas where they are used. Hence, a designer must not think of adding discrete devices to a structure to obtain an effect, but rather must design a structural system which accounts for the physical principles of all the elements in the structure. The purpose of this manual is to provide practicing engineers the information necessary to incorporate piezoelectric materials in structural design and machine design. First, we will review the solid-state physics of piezoelectric materials. Then we will discuss the physical characteristics of the electrical-active material-structural system. We will present the elements of this system which must be considered as part of the design task for a structural engineer. We will cover simple modeling techniques and review the features and capabilities of commercial design tools that are available. We will then cover practical how-to elements of working with piezoceramic materials. We will review sources of piezoceramic materials and built-up devices, and their characteristics. Finally, we will provide two design examples using piezoceramic materials, first as discrete actuators for vibration isolation, and second as structurally-distributed sensor/actuators for active acoustic control.
Detecting anomalous and unknown intrusions against programs

The ubiquity of the Internet connection to desktops has been both a boon to business as well as a cause for concern for the security of digital assets that may be unknowingly exposed. Firewalls have been the most commonly deployed solution to secure corporate assets against intrusions, but firewalls are vulnerable to errors in configuration, ambiguous security policies, data-driven attacks through allowed services, and insider attacks. The failure of firewalls to adequately protect digital assets from computer-based attacks has been a boon to commercial intrusion detection tools. Two general approaches to detecting computer security intrusions in real time are misuse detection and anomaly detection. Misuse detection attempts to detect known attacks against computer systems. Anomaly detection uses knowledge of users' normal behavior to detect attempted attacks. The primary advantage of anomaly detection over misuse detection methods is the ability to detect novel and unknown intrusions. This paper presents a study in employing neural networks to detect the existence of anomalous and unknown intrusions against a software system using the anomaly detection approach.
A Model for Musical Rhythm

At least four elements characterize musical rhythm: 1) metric content, a quantized attribute; 2) ametric phrases, those unrelated to any tactus; 3) tempo variation, change in the number of beats per second; and 4) event shifting, time deviations from a steady beat. This deconstruction provides a means to represent timing features from di erent musical styles. Both tempo variation and event shift information can operate at di erent levels of the metric hierarchy found in music. This representation will facilitate the analysis and production of musical style to the extent that it is rhythmically expressed.
Pathological Mechanisms of Fatal Late Coronary Stent Thrombosis in Humans

Background—Coronary stent deployment is associated with a low incidence of acute thrombosis. However, late stent thrombosis (LST) has likely been underrecognized clinically, and pathological descriptions are lacking. Methods and Results—LST was defined as an acute thrombus within a stent that had been in place ≥30 days. Cases of LST were selected from a registry of human coronary stents submitted for analysis. Thirteen cases of LST (9 men, 4 women) were identified. The mean duration from implantation to thrombosis was 3.6±3.5 months (range, 1 to 11.9 months). The causes of death were sudden cardiac death (n=10), acute myocardial infarction (n=2), and heart failure (n=1). The pathological mechanisms of LST were as follows: (1) stenting across ostia of major arterial branches (5 cases); (2) exposure to radiation therapy (3 cases); (3) plaque disruption in the nonstented arterial segment within 2 mm of the stent margin (2 cases); (4) stenting of markedly necrotic, lipid-rich plaques with extensive plaque prolapse (2 cases); and (5) diffuse in-stent restenosis (1 case). Twelve cases demonstrated a failure to form a completely healed neointimal layer overlying stent struts. Underlying in-stent restenosis was present in only 4 (31%) of 13 cases. Conclusions—LST is a potentially fatal complication of coronary stenting. Stenting across branch ostia, disruption of adjacent vulnerable plaques, radiation therapy, and extensive plaque prolapse can precipitate LST. Impaired intimal healing (ie, the failure to form a complete neointimal layer over stent struts) extends the window during which stents are prone to thrombosis.
Fundamental relations between short-term RR interval and arterial pressure oscillations in humans.

BACKGROUND One of the principal explanations for respiratory sinus arrhythmia is that it reflects arterial baroreflex buffering of respiration-induced arterial pressure fluctuations. If this explanation is correct, then elimination of RR interval fluctuations should increase respiratory arterial pressure fluctuations. METHODS AND RESULTS We measured RR interval and arterial pressure fluctuations during normal sinus rhythm and fixed-rate atrial pacing at 17.2+/-1.8 (SEM) beats per minute greater than the sinus rate in 16 healthy men and 4 healthy women, 20 to 34 years of age. Measurements were made during controlled-frequency breathing (15 breaths per minute or 0.25 Hz) with subjects in the supine and 40 degree head-up tilt positions. We characterized RR interval and arterial pressure variabilities in low-frequency (0.05 to 0.15 Hz) and respiratory-frequency (0.20 to 0.30 Hz) ranges with fast Fourier transform power spectra and used cross-spectral analysis to determine the phase relation between the two signals. As expected, cardiac pacing eliminated beat-to-beat RR interval variability. Against expectations, however, cardiac pacing in the supine position significantly reduced arterial pressure oscillations in the respiratory frequency (systolic, 6.8+/-1.8 to 2.9 +/-0.6 mm Hg2/Hz, P=.017). In contrast, cardiac pacing in the 40 degree tilt position increased arterial pressure variability (systolic, 8.0+/-1.8 to 10.8 +/-2.6, P=.027). Cross-spectral analysis showed that 40 degree tilt shifted the phase relation between systolic pressure and RR interval at the respiratory frequency from positive to negative (9 +/-7 degrees versus -17+/-11 degrees, P=.04); that is, in the supine position, RR interval changes appeared to lead arterial pressure changes, and in the upright position, RR interval changes appeared to follow arterial pressure changes. CONCLUSIONS These results demonstrate that respiratory sinus arrhythmia can actually contribute to respiratory arterial pressure fluctuations. Therefore, respiratory sinus arrhythmia does not represent simple baroreflex buffering of arterial pressure.
On Designing Robust Path-Delay Fault Testable Combinational Circuits Based on Functional Properties

Although path-delay faults (PDF) have been studied extensively during the last three decades, design of combinational circuits to achieve low-overhead robust PDF testability, still poses many challenges. In this paper, we revisit the problem of synthesizing a robust path-delay fault testable combinational circuit based on certain new functional properties. Given the boolean cubes of a function, we first design a two-level robust PDF testable circuit by properly grouping the cubes using a few additional control lines. Next, we apply some testability-preserving algebraic factorization techniques to design multi-level circuits. The method readily extends to multi-output circuits as well. Experimental results establish that the proposed functional approach yields fully robust PDF-testable circuits with much lower overhead as compared to earlier approaches.
Genetic structure of harbour porpoise Phocoena phocoena populations in the northwest Atlantic based on mitochondrial and nuclear markers

The harbour porpoise, Phocoena phocoena, experiences high levels of nonnatural mortality owing to interactions with commercial fisheries throughout its range. To accurately evaluate the significance of this bycatch, information on population structure is required. We have examined the population structure of this species in the northwest Atlantic Ocean using mitochondrial DNA (mtDNA) sequence and nuclear microsatellite data. Samples from four previously proposed summer breeding populations—the Gulf of Maine, eastern Newfoundland, the Gulf of St Lawrence and West Greenland—were analysed. Control‐region sequences revealed a significant partitioning of genetic variation among most of these summer populations, indicating that northwest Atlantic harbour porpoises should not be considered one panmictic population. Analysis of females alone yielded the highest levels of population subdivision, suggesting that females are more philopatric than males. At least three management units may be defined for harbour porpoises in the northwest Atlantic based on these data. Analysis of six microsatellite loci failed to detect significant population subdivision. Male‐mediated gene flow may maintain homogeneity among nuclear loci, while female philopatry is sufficient to produce a signal of population subdivision in the maternally inherited mtDNA genome. mtDNA analyses also indicate that winter aggregations of harbour porpoises along the US mid‐Atlantic states comprise animals from more than one summer breeding population.
Data-Driven Mortality Prediction for Trauma Patients

Trauma is the leading cause of death between the ages of 1 to 44. A large number of these deaths occur within days of the arrival of the patient at the hospital. Accurate prediction of the outcomes of trauma patients and the identification of a few key predictors would be highly valuable. In this paper we focus on (1) the prediction of mortality within any given time frame after arrival, and (2) the selection of key predictors. We consider that patients have both static and temporal data, and that a large number of missing values is inevitable in this type of dataset. We propose a novel mortality prediction model, which extends the logistic regression with elastic net to accommodate large numbers of missing values as well as highly-correlated time-course data. Specifically, we formulate the prediction of mortality as a logistic regression with elastic net regularization by employing static data and all temporal measurements up to the current time. We include an impact function in the weights of each group of time measurements to reduce the correlation across different time points. The impact function is a function of time, which can be adjusted to emphasize earlier or later measurements. We also include a scaled missing value indicator function, which allows us to accommodate variable numbers of missing values. Our method preserves the sparsity property of the elastic net while extending its applicability to time course data with numerous missing values. We compare our method to unmodified logistic regression with elastic net run on either the first or the last time point measurements in the dataset.
Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei

The defined shape and single-copy organelles of Trypanosoma brucei mean that it provides an excellent model in which to study how duplication and segregation of organelles is interfaced with morphogenesis of overall cell shape and form. The centriole or basal body of eukaryotic cells is often seen to be at the centre of such processes. We have used a combination of electron microscopy and electron tomography techniques to provide a detailed three-dimensional view of duplication of the basal body in trypanosomes. We show that the basal body duplication and maturation cycle exerts an influence on the intimately associated flagellar pocket membrane system that is the portal for secretion and uptake from this cell. At the start of the cell cycle, a probasal body is positioned anterior to the basal body of the existing flagellum. At the G1–S transition, the probasal body matures, elongates and invades the pre-existing flagellar pocket to form the new flagellar axoneme. The new basal body undergoes a spectacular anti-clockwise rotation around the old flagellum, while its short new axoneme is associated with the pre-existing flagellar pocket. This rotation and subsequent posterior movements results in division of the flagellar pocket and ultimately sets parameters for subsequent daughter cell morphogenesis.
Influence of Lateral Shift on Normal Moveout of SH-Wave

Using the lateral shift and shift time of reflection coefficient of SH seismic wave at the interface of strata, , we derived and given formulae of normal moveout of lateral shift, discussed the influence of lateral shift on normal moveout of SH-wave, and drawn the curves of normal moveout of lateral shift and the error of normal moveout caused by lateral shift with respect to the angle of incidence. The results show that for glancing wave or angle of incidence being near the critical angle, A large error can be caused by t lateral shift; The error correction of lateral shift should be done before seismic data processing.