Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility of a Combined Aerobic and Strength Training Program and Its Effects on Cognitive and Physical Function in Institutionalized Dementia Patients. A Pilot Study

Objectives We examined the feasibility of a combined aerobic and strength training program in institutionalized dementia patients and studied the effects on cognitive and physical function. Methods Thirty-three patients with dementia, recruited from one nursing home, participated in this non-randomized pilot study (25 women; age = 85.2±4.9 years; Mini Mental State Examination = 16.8±4.0). In phase 1 of the study, seventeen patients in the Exercise group (EG) received a combined aerobic and strength training program for six weeks, five times per week, 30 minutes per session, in an individually supervised format and successfully concluded the pre and posttests. In phase 2 of the study, sixteen patients in the Social group (SG) received social visits at the same frequency, duration, and format and successfully concluded the pre and posttests. Results Indices of feasibility showed that the recruitment and adherence rate, respectively were 46.2% and 86.3%. All EG patients completed the exercise program according to protocol without adverse events. After the six-week program, no significant differences on cognitive function tests were found between the EG and SG. There was a moderate effect size in favor for the EG for the Visual Memory Span Forward; a visual attention test. There were significant differences between groups in favor for the EG with moderate to large effects for the physical tests Walking Speed (p = .003), Six-Minute Walk Test (p = .031), and isometric quadriceps strength (p = .012). Conclusions The present pilot study showed that it is feasible to conduct a combined aerobic and strength training program in institutionalized patients with dementia. The selective cognitive visual attention improvements and more robust changes in motor function in favor of EG vs. SG could serve as a basis for large randomized clinical trials. Trial Registration trialregister.nl 1230
Scalable Ethernet Architecture Using SDN by Suppressing Broadcast Traffic

The simplicity and high performance-to-cost ratio make Ethernet, the most dominant and widely deployed LAN technology. But, a single Ethernet network cannot scale to large networks such as enterprise, campus, data center and wide area networks because of broadcast based services like Address Resolution Protocol (ARP) and Dynamic Host Configuration Protocol (DHCP). The Software-Defined Networking (SDN) based scheme SEASDN is proposed here to effectively enhance the scalability of Ethernet by suppressing broadcast traffic. In this scheme, DHCP and ARP broadcast messages are relayed through SDN controller to the destination and thus eliminating the need for broadcasting. The proposed scheme can eliminate flooding without any change to the existing hardware, software and protocols of hosts and also can detect ARP spoofing attack. The simulation results show that SEASDN is very much effective in ARP and DHCP broadcast suppression than the current SDN broadcast handling methods while reducing control plane overhead and data plane traffic significantly.
Improved document classification through enhanced Naive Bayes algorithm

Immense growth in communication has paved way for existence of information across the world in wide separated zones. There exists a need for a mechanism to render apt information to the needy from this enormous source of information. This mechanism is of high demand for educational purposes. Knowledge based cloud (Kloud) proposes a solution to combine together the information in different area, which is managed by several organizations. It then organizes them into different sections and hence providing a platform to furnish relevant information to people in search of it. The paper discusses about a method based on Naive Bayes algorithm to classify documents pushed into "Kloud". A variation to this algorithm has been implemented by calculating term weight using "converged weight" method resulting in better accuracy and speed. A comparative study of proposed variance in classification algorithm against the actual algorithm was performed. Further we also implemented two subclassification algorithms namely hierarchical subclassification and subcategorization using document similarity method.
Presynaptic G-Protein-Coupled Receptors Dynamically Modify Vesicle Fusion, Synaptic Cleft Glutamate Concentrations, and Motor Behavior

Understanding how neuromodulators regulate behavior requires investigating their effects on functional neural systems, but also their underlying cellular mechanisms. Utilizing extensively characterized lamprey motor circuits, and the unique access to reticulospinal presynaptic terminals in the intact spinal cord that initiate these behaviors, we investigated effects of presynaptic G-protein-coupled receptors on locomotion from the systems level, to the molecular control of vesicle fusion. 5-HT inhibits neurotransmitter release via a Gβγ interaction with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex that promotes kiss-and-run vesicle fusion. In the lamprey spinal cord, we demonstrate that, although presynaptic 5-HT receptors inhibit evoked neurotransmitter release from reticulospinal command neurons, their activation does not abolish locomotion but rather modulates locomotor rhythms. Liberation of presynaptic Gβγ causes substantial inhibition of AMPA receptor-mediated synaptic responses but leaves NMDA receptor-mediated components of neurotransmission mostly intact. Because Gβγ binding to the SNARE complex is displaced by Ca2+-synaptotagmin binding, 5-HT-mediated inhibition displays Ca2+ sensitivity. We show that, as Ca2+ accumulates presynaptically during physiological bouts of activity, 5-HT/Gβγ-mediated presynaptic inhibition is relieved, leading to a frequency-dependent increase in synaptic concentrations of glutamate. This frequency-dependent phenomenon mirrors a shift in the vesicle fusion mode and a recovery of AMPA receptor-mediated EPSCs from inhibition without a modification of NMDA receptor EPSCs. We conclude that activation of presynaptic 5-HT G-protein-coupled receptors state-dependently alters vesicle fusion properties to shift the weight of NMDA versus AMPA receptor-mediated responses at excitatory synapses. We have therefore identified a novel mechanism in which modification of vesicle fusion modes may profoundly alter locomotor behavior.
Rekindling the love of books – a pilot project exploring whether e-readers help people to read again after a stroke

Background: E-readers may facilitate reading in aphasia through “aphasia-friendly” features such as altering text size and formatting, and text-to-speech functions. However, no previous research has examined whether e-readers help people with aphasia to read. Aims: This project explored: whether people with aphasia can learn to use e-readers following a brief period of training, whether e-reader training improves reading comprehension, and whether e-readers increase participation in and enjoyment of reading activities Method and procedures: In phase one, available e-readers were compared using an expert evaluation against a set of criteria, to identify the model with optimum accessibility features and fewest potential barriers. The Kindle Keyboard 3GTM (Amazon) was selected for trialling in phase two. Four people with self-reported reading difficulties poststroke participated in phase two. All had mild or mild-moderate aphasia. Four 1-hr training sessions aimed to trial accessibility features, identify helpful features, and teach independent operation of these. A repeated measures design was used. Outcome measures assessed reading comprehension (Gray Oral Reading Tests (GORT-4)) and confidence and emotions associated with reading (Reading Confidence and Emotions Questionnaire (RCEQ)). Matched texts were used to compare reading comprehension using printed texts and the e-reader. Usability evaluations explored independence in e-reader use and acceptability of the technology. Participation in reading activities and reading enjoyment were explored using qualitative exit interviews. Outcomes and results: Participants’ reading comprehension on the Kindle, as measured by GORT-4, did not improve following training and did not exceed comprehension of printed texts. However, reading confidence improved significantly for three of the participants (RCEQ: p < .05, p < .01, and p < .005). Analysis of exit interviews and usability evaluations indicates that three out of four participants preferred reading on the Kindle to printed texts. These participants read more frequently on the Kindle than they had done before the training, and the technology enabled them to access more challenging texts (e.g., novels). They appreciated different features of the Kindle. Two participants experienced difficulties operating the technology, one of whom would have benefited from a longer training period. Conclusions: This pilot study suggests that a short block of e-reader training led to improvements in reading confidence, participation, and enjoyment. E-readers were not shown to enhance reading comprehension. Larger-scale investigations are warranted to further investigate whether and how e-readers facilitate reading for people with aphasia.
Effect of Mental Practice on the Development of a Certain Motor Skill

Abstract The effect of mental practice was compared with that of physical practice in the development of a motor skill, the Pacific Coast one-hand foul shot. One hundred and forty-four high school boys were equated into physical and mental practice groups on the basis of arm strength, intelligence, and varsity, junior varsity, or novice experience. Mental practice was found to be nearly as effective as physical practice under the conditions of the experiment. PHYSICAL EDUCATORS and coaches are becoming increasingly aware of the potential importance of the mental aspects of motor learning. To date, this awareness seems to be based more on intuition than on research evidence. For example, an extensive examination of literature disclosed only a few pieces of research that were designed primarily to investigate the effect of mental practice on the learning of motor skill. Wilbur E. Twining (11) made an observation in 1949 that is still true. In spite of the rapid advancement in the scientific approach to phys.
Selective and uncoupled role of substrate elasticity in the regulation of replication and transcription in epithelial cells

Actin cytoskeleton forms a physical connection between the extracellular matrix, adhesion complexes and nuclear architecture. Because tissue stiffness plays key roles in adhesion and cytoskeletal organization, an important open question concerns the influence of substrate elasticity on replication and transcription. To answer this major question, polyelectrolyte multilayer films were used as substrate models with apparent elastic moduli ranging from 0 to 500 kPa. The sequential relationship between Rac1, vinculin adhesion assembly, and replication becomes efficient at above 200 kPa because activation of Rac1 leads to vinculin assembly, actin fiber formation and, subsequently, to initiation of replication. An optimal window of elasticity (200 kPa) is required for activation of focal adhesion kinase through auto-phosphorylation of tyrosine 397. Transcription, including nuclear recruitment of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), occurred above 50 kPa. Actin fiber and focal adhesion signaling are not required for transcription. Above 50 kPa, transcription was correlated with αv-integrin engagement together with histone H3 hyperacetylation and chromatin decondensation, allowing little cell spreading. By contrast, soft substrate (below 50 kPa) promoted morphological changes characteristic of apoptosis, including cell rounding, nucleus condensation, loss of focal adhesions and exposure of phosphatidylserine at the outer cell surface. On the basis of our data, we propose a selective and uncoupled contribution from the substrate elasticity to the regulation of replication and transcription activities for an epithelial cell model.
Designing a Web Based Digital Library Management System for Institutions and Colleges

As the number of documents in digital library grows, it becomes increasingly difficult to store, manage the large amount of documents and find requested relevant documents by users. A Web based Digital Library management System (DLMS) was designed for this purpose. It helps to create unlimited quantity of digital information and make it available to the world in parallel. The system is designed to acquire research materials for the institution and then publish it to users in their remote areas. The design parameters are Java Programming language, PHP and HTML; Database type: MYSQL. It is designed as an interactive and content management system. The content management system deals with data entry, validation and updating while the interactive system deals with system interaction with the users.
RELAÇÃO ENTRE ATRIBUTOS DO SISTEMA DE CONTABILIDADE E NÍVEL DE SATISFAÇÃO DOS USUÁRIOS: UMA ANÁLISE EM ORGANIZAÇÕES BRASILEIRAS

O presente artigo tem por objetivo analisar a relacao entre os atributos do sistema de informacao de contabilidade gerencial e o nivel de satisfacao dos usuarios desse sistema. As caracteristicas qualitativas da informacao contabil contribuem para a utilidade da informacao contabil gerencial. Os atributos do sistema de informacao contabil gerencial sao os instrumentos por meio dos quais as referidas caracteristicas sao atingidas. Tais atributos foram definidos tendo por base o modelo conceitual de Moores e Yuen (2001) que foi utilizado a partir de dados coletados em uma pesquisa de campo junto as organizacoes classificadas entre as de medio e de grande porte no Brasil, definidas de maneira probabilistica. A analise dos dados inclui analise multivariada, sendo utilizado o metodo do cluster . Os resultados indicam que os usuarios da informacao contabil gerencial estarao mais satisfeitos a medida que os atributos lhes permitam obter informacoes uteis atraves dos sistemas de informacao contabil de suas entidades. Futuras pesquisas podem investigar quais os atributos que mais contribuem para a satisfacao dos usuarios da informacao contabil.
The ORF3 Protein of Porcine Circovirus Type 2 Is Involved in Viral Pathogenesis In Vivo

ABSTRACT Porcine circovirus type 2 (PCV2) is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome. We previously showed that a novel identified protein, ORF3, was not essential for PCV2 replication in cultured PK15 cells and played a major role in virus-induced apoptosis. To evaluate the role of the ORF3 protein in viral pathogenesis in vivo, we inoculated 8-week-old BALB/c mice that have been developed for PCV2 replication with ORF3-deficient mutant PCV2 (mPCV2). By 42 days postinoculation, all of the mice inoculated with the mPCV2, as well as with wild-type PCV2 (wPCV2), had seroconverted to PCV2 capsid antibody, and the mutant induced levels of PCV2 antibodies that were higher than those of the wPCV2. The PCV2 genomic copy numbers in serum were significantly higher (P < 0.05) in the wPCV2-inoculated mice than in mice inoculated with the mPCV2. Also, the wPCV2 caused microscopic lesions characterized by lymphocyte depletion with histiocytic infiltration of lymphoid organs, but the mutant virus failed to induce any obvious pathological lesions. In situ hybridization and immunohistochemical analyses also showed that larger amounts of viral DNA and antigens were detected in the lymph nodes of the wPCV2-inoculated than mPCV2-inoculated mice. Furthermore, animals of the wPCV2-inoculated group showed significant downshifts of CD8+ T-cell subsets of peripheral blood lymphocytes compared to the control mice (P < 0.05) at various time points postinoculation. Also, the proportions of the CD4+ and CD4+ CD8+ cells were significantly reduced in wPCV2-inoculated mice at some time points postinoculation. In contrast, there are some reductions in the proportions of these subsets in the mutant virus-inoculated mice, but the proportions do not decrease significantly. Taken together, these results demonstrate that the ORF3 protein is also dispensable for viral replication in vivo and that it plays an important role in viral pathogenesis.
Transcriptional control of noise in gene expression

Cis-regulatory control of transcription is the dominant form of regulation of gene expression. Recent experimental results suggest that, in addition to the mean expression level, cell-to-cell variability might also be transcriptionally regulated. Here, we develop a stochastic model of transcriptional regulation that allows us to calculate closed-form analytical expressions for the mean and variance of the protein and mRNA distributions for an arbitrarily complex cis-regulatory motif. Our model allows us to investigate how noise may be transcriptionally regulated independently from the mean expression. We show that our approach is in excellent agreement with stochastic simulations and experiment, and leads to an experimentally testable formula for the noise in gene expression as a function of inducer-molecule concentrations.
The use of data mining classification technique to fill in structural positions in bogor local government

The human resources of Bogor local government are managed by human resources and training division, which is called Badan Kepegawaian Pendidikan dan Pelatihan (BKPP). BKPP form a team called Badan Pertimbangan Jabatan dan Kepangkatan (Baperjakat), which are responsible for promoting, rotating and dismissing local government employees from structural positions below the Echelon IIA positions. Baperjakat have problems on constructing the draft of structural government positions. These processes were done manually, even though BKPP have a human resources information systems called SIMPEG. The main purpose of this research is to identify patterns to fill in structural positions in Bogor Local Government. 62 Classifications algortithms were tested using 3 data mining tools with 7 data sets and 7 human resources attributes to identify filling structural position patterns. The classification process yields Classification Rule with Unbiased Interaction Selection and Estimation (CRUISE) as the best algorithm in echelon class. Its average accuracy is 95.7% for each echelon level.
Inexact Data-Sparse Boundary Element Tearing and Interconnecting Methods

The boundary element tearing and interconnecting (BETI) methods have recently been introduced as boundary element counterparts of the well-established finite element tearing and interconnecting (FETI) methods. In this paper we present inexact data-sparse versions of the BETI methods which avoid the elimination of the primal unknowns and dense matrices. However, instead of symmetric and positive definite systems, we finally have to solve twofold saddle point problems. The proposed iterative solvers and preconditioners result in almost optimal solvers whose complexity is proportional to the number of unknowns on the skeleton up to some polylogarithmical factor. Moreover, the solvers are robust with respect to large coefficient jumps.
Diffuse sclerosing variant is a major subtype of papillary thyroid carcinoma in the young.

BACKGROUND Pediatric thyroid cancer differs from adult thyroid cancer in presentation and outcome. Pediatric thyroid cancer has a higher recurrence rate and greater percentage of lymph node and pulmonary metastasis. The clinicopathologic characteristics of pediatric thyroid cancer according to the histologic subtype have not been reported, however. In this study, we determined the histological subtypes of pediatric thyroid cancer and analyzed other clinicopathologic characteristics. METHODS All patients with thyroid cancer who were admitted to Severance Hospital, Seoul, South Korea, were retrospectively reviewed; their age was <20 years at diagnosis, and they were seen between January 1995 and August 2008. RESULTS Sixty-eight patients were identified. The histologic types of thyroid carcinoma were papillary thyroid carcinoma (PTC) in 57 (83.8%), follicular carcinoma in 8 (11.8%), and poorly differentiated carcinoma in 3 (4.4%). There were 28 (41.2%) cases of diffuse sclerosing variant of papillary carcinoma (DSVPC), 26 (38.2%) of conventional PTC, 2 (2.9%) of follicular PTC, and 1 (1.5%) cribriform-morular PTC. In patients with PTC, there was a higher incidence of bilateral thyroid involvement (p = 0.003), extrathyroidal extension (p = 0.009), and lymph node involvement (p = 0.018), and lower recurrence-free survival (p = 0.032) in DSVPC than in non-DSVPC. Univariate regression analysis revealed that extrathyroidal extension (p = 0.025) and tumor size (p = 0.001) were positively associated with a shorter time to recurrence. CONCLUSION DSVPC is a major subtype of PTC in the young.
Improving Music Recommendations with a Weighted Factorization of the Tagging Activity

Collaborative filtering systems for music recommendations are often based on implicit feedback derived from listening activity. Hybrid approaches further incorporate additional sources of information in order to improve the quality of the recommendations. In the context of a music streaming service, we present a hybrid model based on matrix factorization techniques that fuses the implicit feedback derived from the users’ listening activity with the tags that users have given to musical items. In contrast to existing work, we introduce a novel approach to exploit tags by performing a weighted factorization of the tagging activity. We evaluate the model for the task of artist recommendation, using the expected percentile rank as metric, extended with confidence intervals to enable the comparison between models. Thus, our contribution is twofold: (1) we introduce a novel model that uses tags to improve music recommendations and (2) we extend the evaluation methodology to compare the performance of different recommender systems.
Loss of Raltegravir Susceptibility by Human Immunodeficiency Virus Type 1 Is Conferred via Multiple Nonoverlapping Genetic Pathways

ABSTRACT The human immunodeficiency virus type 1 (HIV-1) integrase mutations N155H and Q148R(H)(K) that reduce susceptibility to the integrase inhibitor raltegravir have been identified in patients failing treatment regimens containing raltegravir. Whether these resistance mutations occur individually or in combination within a single virus genome has not been defined, nor do we fully understand the impact of these primary mutations and other secondary mutations on raltegravir susceptibility and viral replication capacity. To address these important questions, we investigated the raltegravir susceptibility and replication capacity of viruses containing mutations at positions 155 and 148 separately or in combination with secondary mutations selected in subjects failing treatment regimens containing raltegravir. Clonal analysis demonstrated that N155H and Q148R(H)(K) occur independently, not in combination. Viruses containing a Q148R(H)(K) mutation generally displayed larger reductions in raltegravir susceptibility than viruses with an N155H mutation. Analysis of site-directed mutants indicated that E92Q in combination with N155H resulted in a higher level of resistance to raltegravir than N155H alone. Viruses containing a Q148R(H) mutation together with a G140S mutation were more resistant to raltegravir than viruses containing a Q148R(H) mutation alone; however, viruses containing G140S and Q148K were more susceptible to raltegravir than viruses containing a Q148K mutation alone. Both N155H and Q148R(H)(K) mutations reduced the replication capacity, while the addition of secondary mutations either improved or reduced the replication capacity depending on the primary mutation. This study demonstrates distinct genetic pathways to resistance in subjects failing raltegravir regimens and defines the effects of primary and secondary resistance mutations on raltegravir susceptibility and replication capacity.