Miracle-dz/UniFAR-FTUs huggingface dataset:
Under the mask: The double-edged sword effect of leader self-sacrifice on employee work outcomes

Building on attribution theory, this study applied regression analysis and explored the double-edged sword effect of leader self-sacrifice behavior on employee work outcomes, thus revealing the potential negative impacts of such behavior. Specifically, when leadership self-sacrifice was met with low employee authenticity attribution, we found that employees tended to perceive leadership as hypocritical, thus reducing their organizational citizenship behavior. By contrast, when leaders’ self-sacrifice behavior was met with high employee authenticity attribution, employees tended to trust the leader and improve their task performance. Given these findings, we challenge the general scholarly consensus on leadership self-sacrifice behavior, enrich the current literature on leadership self-sacrifice, and emphasize the important role of employee attribution in the relevant leadership process.
Analysis of a travertine system controlled by the transpressional activity of the Alhama de Murcia fault: The Carraclaca site, eastern Betic Cordillera, Spain

Continental carbonates, such as travertines and tufas, formed from CO2-rich groundwater degassing as it emerges at the Earth’s surface, are often associated with major crustal-scale faults. The Carraclaca site, in the Lorca-Totana section of the Alhama de Murcia Fault, Spain, presents a complex geomorphological landscape controlled by active tectonics. The geology here records the interaction between Quaternary alluvial fans, travertines, and a pop-up structure developed in a transpressional section of the fault. The Alhama de Murcia Fault is an 80 km long left-lateral strike-slip fault that is one of the main seismogenic structures in the Iberian Peninsula. In this work, we examined the relation between travertine precipitation in the Carraclaca site and the tectonic activity of this fault zone through morphological and geochemical studies. The δ13C and δ18O isotopic signals indicate that the carbonate deposits are hydrothermal. In addition, the 87Sr/86Sr ratios in the samples suggest subsurface fluid interaction with the Miocene sediments and the Alpujárride basement, located below the alluvial deposits. Tectonic activity in the Alhama de Murcia Fault might generate the opening of deep water circulation in the crust every time a seismic event occurs, giving rise to hydrothermally derived carbonates precipitation. Deep waters rise and reach the surface interacting with meteoric waters, resulting in travertine formation. Therefore, the Carraclaca carbonate deposits study can inform us about the seismogenic cycle of the fault in the Lorca-Totana section.
Predicting transient ischemic attack risk in patients with mild carotid stenosis using machine learning and CT radiomics

Objective This study aims to establish a radiomics-based machine learning model that predicts the risk of transient ischemic attack in patients with mild carotid stenosis (30–50% North American Symptomatic Carotid Endarterectomy Trial) using extracted computed tomography radiomics features and clinical information. Methods A total of 179 patients underwent carotid computed tomography angiography (CTA), and 219 carotid arteries with a plaque at the carotid bifurcation or proximal to the internal carotid artery were selected. The patients were divided into two groups; patients with symptoms of transient ischemic attack after CTA and patients without symptoms of transient ischemic attack after CTA. Then we performed random sampling methods stratified by the predictive outcome to obtain the training set (N = 165) and testing set (N = 66). 3D Slicer was employed to select the site of plaque on the computed tomography image as the volume of interest. An open-source package PyRadiomics in Python was used to extract radiomics features from the volume of interests. The random forest and logistic regression models were used to screen feature variables, and five classification algorithms were used, including random forest, eXtreme Gradient Boosting, logistic regression, support vector machine, and k-nearest neighbors. Data on radiomic feature information, clinical information, and the combination of these pieces of information were used to generate the model that predicts the risk of transient ischemic attack in patients with mild carotid artery stenosis (30–50% North American Symptomatic Carotid Endarterectomy Trial). Results The random forest model that was built based on the radiomics and clinical feature information had the highest accuracy (area under curve = 0.879; 95% confidence interval, 0.787–0.979). The combined model outperformed the clinical model, whereas the combined model showed no significant difference from the radiomics model. Conclusion The random forest model constructed with both radiomics and clinical information can accurately predict and improve discriminative power of computed tomography angiography in identifying ischemic symptoms in patients with carotid atherosclerosis. This model can aid in guiding the follow-up treatment of patients at high risk.
Editorial: Single cell meets metabolism and cancer biology

COPYRIGHT © 2023 Wang and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 08 February 2023 DOI 10.3389/fonc.2023. 1125186
Paradoxical reduction of plasma lipids and atherosclerosis in mice with adenine-induced chronic kidney disease and hypercholesterolemia

Background Atherosclerotic cardiovascular disease is prevalent among patients with chronic kidney disease (CKD). In this study, we initially aimed to test whether vascular calcification associated with CKD can worsen atherosclerosis. However, a paradoxical finding emerged from attempting to test this hypothesis in a mouse model of adenine-induced CKD. Methods We combined adenine-induced CKD and diet-induced atherosclerosis in mice with a mutation in the low-density lipoprotein receptor gene. In the first study, mice were co-treated with 0.2% adenine in a western diet for 8 weeks to induce CKD and atherosclerosis simultaneously. In the second study, mice were pre-treated with adenine in a regular diet for 8 weeks, followed by a western diet for another 8 weeks. Results Co-treatment with adenine and a western diet resulted in a reduction of plasma triglycerides and cholesterol, liver lipid contents, and atherosclerosis in co-treated mice when compared with the western-only group, despite a fully penetrant CKD phenotype developed in response to adenine. In the two-step model, renal tubulointerstitial damage and polyuria persisted after the discontinuation of adenine in the adenine-pre-treated mice. The mice, however, had similar plasma triglycerides, cholesterol, liver lipid contents, and aortic root atherosclerosis after being fed a western diet, irrespective of adenine pre-treatment. Unexpectedly, adenine pre-treated mice consumed twice the calories from the diet as those not pre-treated without showing an increase in body weight. Conclusion The adenine-induced CKD model does not recapitulate accelerated atherosclerosis, limiting its use in pre-clinical studies. The results indicate that excessive adenine intake impacts lipid metabolism.
Associational protection of urban ash trees treated with systemic insecticides against emerald ash borer

Emerald ash borer (EAB), Agrilus plannipenis Fairmaire, is an invasive insect accidentally introduced to North America from Asia that attacks and kills ash trees (Fraxinus spp.). A common control strategy in urban centers has been the injection of systemic insecticides into mature trees, which can be costly at large scales. This study investigated whether treating a subset of a susceptible urban ash population could confer associational protection to untreated trees; i.e. improving or maintaining crown health of the latter. We selected approximately 100 mature ash trees along city streets in each of 12 sites in central and southeastern Minnesota in 2017. Each site had low but growing infestations of EAB such that canopy decline was not yet widespread. We treated 50% of trees with emamectin benzoate in eight sites and 50% of trees in four sites with azadirachtin in site-wide spatial gradients, such that the remaining 50% of trees at all sites were left untreated. Crown health of all trees was monitored for five years (2017 to 2021). Across all sites, we noted an overall maintenance or increase in crown health of both treated and untreated trees, while groups of untreated reference trees approximately three km distant from each site to monitor general tree health and EAB pressure declined quickly. These results suggested that protective benefits were conferred by treated trees to untreated trees within sites. Quantifying the spatial scale of canopy preservation of untreated trees within sites proved challenging due to the lack of variation in crown condition between treated and untreated trees. In two of the twelve sites treated with emamectin benzoate, we noted statistical evidence of improvements in crown condition of untreated trees when located within 100m of treated trees. Treating a subset of a susceptible ash population may aid in preserving untreated trees and provides a basis for developing a more cost-effective and environmentally favorable treatment regimen against EAB.
Clinical and pathologic characteristics of appendiceal neuroendocrine neoplasms diagnosed during pregnancy

Introduction Although appendicitis occurs in approximately 1:1000 pregnancies, appendiceal neuroendocrine neoplasm (ANEN) diagnosis during pregnancy is very rare. Data on presentation, treatment and prognosis is scarce. Aim To describe ANEN cases diagnosed during pregnancy. Materials and methods A retrospective appraisal of 7 consecutive ANEN patients diagnosed during pregnancy from four Israeli tertiary medical centers and comparison with 17 cases described in the literature from 1965-2021. Results Age at ANEN diagnosis was 26.4 ± 3.5 years (range 21-33). Patients were diagnosed between gestational weeks 6-40, most frequently in the third trimester (53%). The most common presenting symptom was abdominal pain. Tumor size was 14.3 ± 8.9mm (range 3-45mm). In patients from our series appendiceal base involvement was reported in 2/7; mesoappendiceal invasion in 5/7; lympho-vascular invasion in 2/7. Ki67 staining was reported in 6/7 cases and ranged from 1-10%. Pathology details were lacking in most of the previously published cases. All 7 pregnancies in our series resulted in term delivery with no complications, whereas in historical cases there were one first trimester abortion, one ectopic pregnancy, and one stillbirth. Right hemicolectomy was performed in 5/7 patients in our series and reported in 2/17 historical cases. All hemicolectomies were performed after delivery, 3-16 months after appendectomy. Local metastases were reported in two cases. Follow-up duration was 7-98 months for our patients and 3-48 months in 5 historical cases. No disease recurrence, distant metastases or mortality were noted. Conclusions To the best of our knowledge, this is the largest series describing the extremely rare diagnosis of ANEN during pregnancy. Although pathologic characteristics varied, pregnancy outcomes were usually favorable and long-term prognosis was excellent. This data may suggest that a conservative approach to patients with ANEN diagnosis during pregnancy can be considered.
Industry-specific prevalence and gender disparity of common mental health problems in the UK: A national repetitive cross-sectional study

Aims The aim of the study was to evaluate the prevalence and temporal trend of common mental health problems (CMHPs) in the UK by industrial classification from 2012–2014 to 2016–2018 while evaluating the corresponding gender disparities. Methods We used data from the Health Survey for England. CMPH was judged by a 12-item General Health Questionnaire. Industrial classifications were defined using the UK Standard Industrial Classification of Economic Activities. Data were fitted by the logistic models. Results In this study, 19,581 participants covering 20 industries were included. In total, 18.8% of participants screened positive for CMHP in 2016–2018, which significantly increased from 16.0% in 2012–2014 [adjusted OR (AOR) = 1.17, 95% CI 1.08–1.27]. In 2016–2018, the prevalence of CMHP ranged from 6.2% in the industry of mining and quarrying to 23.8% in the industry of accommodation and food service activities. From 2012–2014 to 2016–2018, none of the 20 industries studied experienced significant decreases in the above prevalence; conversely, three industries saw significant increases, including wholesale and retail trade, repair of motor vehicles and motorcycles (AOR for trend = 1.32, 95% CI 1.04–1.67), construction (AOR for trend = 1.66, 95% CI 1.23–2.24), and other service activities, which cannot be classified (AOR for trend = 1.94, 95% CI 1.06–3.55). In total, 11 of the 20 industries studied had significant gender disparities against women, with the smallest gap being in the industry of transport and storage (AOR = 1.47, 95% CI 1.09–2.0) and the highest in the industry of arts, entertainment, and recreation (AOR = 6.19, 95% CI 2.94–13.03). From 2012–2014 to 2016–2018, gender disparities were narrowed only in two industries, including human health and social work activities (AOR for trend = 0.45, 95% CI 0.27–0.74), and transport and storage (AOR for trend = 0.5, 95% CI 0.27–0.91). Conclusion The prevalence of CMHPs has increased and had a wide variation across industries in the UK. There were disparities against women, and the gender disparities have been keeping almost no improvement from 2012–2014 to 2016–2018.
Systematic review of probiotics as an adjuvant treatment for psychiatric disorders

Introduction Many psychiatric illnesses have been linked to the gut microbiome, with supplements such as probiotics showing some efficacy in alleviating the symptoms of some psychiatric illnesses. The aim of this review is to evaluate the current literature investigating the effects of adjuvant probiotic or synbiotic administration in combination with first-line treatments for psychiatric illnesses. Method A systematic search of four databases was conducted using key terms related to treatments for psychiatric illnesses, the gut microbiome, and probiotics. All results were then evaluated based on specific eligibility criteria. Results Eight studies met eligibility criteria and were analyzed for reported changes in outcome measures used to assess the symptoms of psychiatric illness and the tolerability of treatment. All Major Depressive Disorder (MDD) (n = 5) and Generalized Anxiety Disorder (GAD) (n = 1) studies found adjuvant probiotic or synbiotic treatment to be more efficacious in improving the symptoms of psychiatric illness than the first-line treatment alone or with placebo. The schizophrenia studies (n = 2) found adjuvant probiotic treatment to have no significant difference in clinical outcomes, but it was found to improve the tolerability of first-line antipsychotics. Discussion and conclusion The findings of the studies included in this review suggest the use of adjuvant probiotic treatment with selective serotonin reuptake inhibitors (SSRIs) for MDD and GAD to be superior to SSRI treatment alone. Probiotic adjuvant treatment with antipsychotics could be beneficial for improving the tolerability of the antipsychotics, but these findings do not suggest that adjuvant probiotic treatment would result in improved clinical outcomes for symptoms of schizophrenia.
Altered hierarchical organization between empathy and gambling networks in disordered gamblers

Background Despite the demonstrated association between empathy and gambling at the behavioral level, limited neuroimaging research on empathy and gambling disorder (GD) has been conducted. Whether and how the brain network of empathy and that of gambling interact in disordered gamblers has not been investigated. This study aimed to address this research gap by examining the hierarchical organizational patterns, in which the differences of causal interactions of these networks between disordered gamblers and healthy controls were revealed. Methods Resting-state functional magnetic resonance imaging (fMRI) data of 32 disordered gamblers and 56 healthy controls were included in the formal analysis. Dynamic causal modeling was used to examine the effective connectivity within and between empathy and gambling networks among all participants. Results All participants showed significant effective connectivity within and between empathy and gambling networks. However, compared with healthy controls, disordered gamblers displayed more excitatory effective connectivity within the gambling network, the tendency to display more excitatory effective connectivity from the empathy network to the gambling network, and reduced inhibitory effective connectivity from the gambling network to the empathy network. Conclusion The exploratory study was the first to examine the effective connectivity within and between empathy and gambling networks among disordered gamblers and healthy controls. These results provided insights into the causal relationship between empathy and gambling from the neuroscientific perspective and further confirmed that disordered gamblers show altered effective connectivity within and between these two brain networks, which may be considered to be a potential neural index for GD identification. In addition, the altered interactions between empathy and gambling networks may also indicate the potential targets for the neuro-stimulation intervention approach (e.g., transcranial magnetic stimulation).
Additional improvement in regional myocardial ischemia after intracardiac injection of bone marrow cells during CABG surgery

Background Post-procedure residual ischemia is associated with worse prognosis in patients with coronary artery diasease (CAD). Objective We evaluated whether autologous bone marrow-derived cells (BMC) contribute to additional reduction in regional stress-induced myocardial ischemia (SIMI) in patients undergoing incomplete coronary artery bypass graft surgery (CABG). Methods In a double-blind, randomized, placebo-controlled trial, we enrolled 143 patients (82% men, 58 ± 11 years) with stable CAD and not candidates for complete CABG. They received 100 million BMC (n = 77) or placebo (n = 66) injected into ischemic non-revascularized segments during CABG. The primary outcome was improvement on SIMI quantified as the area at risk in injected segments assessed by cardiovascular magnetic resonance (CMR) 1, 6, and 12 months after CABG. Results The reduction in global SIMI after CABG was comparable (p = 0.491) in both groups indicating sustained beneficial effects of the surgical procedure over 12 month period. In contrast, we observed additional improvement in regional SIMI in BMC treated group (p = 0.047). Baseline regional SIMI values were comparable [18.5 (16.2–21.0) vs. 18.5 (16.5–20.7)] and reached the lowest values at 1 month [9.74 (8.25; 11.49) vs. 12.69 (10.84; 14.85)] for BMC and placebo groups, respectively. The ischemia’s improvement from baseline represented a 50% difference in regional SIMI in favor of the BMC transplanted group at 30 days. We found no differences in clinical and LVEF% between groups during the 12 month follow-up period. The 1 month rate of major adverse cerebral and cardiovascular events (MACCE) (p = 0.34) and all-cause mortality (p = 0.08) did not differ between groups 1 month post intervention. Conclusion We provided evidence that BMC leads to additional reduction in regional SIMI in chronic ischemic patients when injected in segments not subjected to direct surgical revascularization. This adjuvant therapy deserves further assessment in patients with advanced CAD especially in those with microcirculation dysfunction. Clinical trial registration https://clinicaltrials.gov/, identifier NCT01727063
Simulation of red tide drift-diffusion process in the Pearl River Estuary and its response to the environment

A particle tracking model for the Lingdingyang Bay of the Pearl River Estuary (PRE) was established based on the Delft3D model. The model was initialized with remote sensing images to simulate the red tide drift-diffusion process in this sea area in the autumn of 2020 and analyze its response to tides, winds and runoffs. The results show that this red tide occurred in the central sea area of the Lingdingyang Bay. The red tide drifted south with the ebb tide and north with flood tide. The red tide spread northward to the waters near Humen and southward to the western waters of Zhuhai. Through the control variable experiments, it is found that the red tide drift-diffusion process was mainly affected by tide and wind, with minimal influence from runoff. The tide expanded the scope of red tide diffusion, and the wind further changed the distribution of red tide. Under the influence of the northeast wind, the red tide gathered on both sides of Lingdingyang Bay. Comparison with the red tide drift-diffusion process in the sea area near Shenzhen Airport shows that the red tide near Neilingding Island easily diffused toward surrounding waters.
Seasonal variability of nektonic community structure and phylogenetic diversity in Weizhou Island, the Beibu Gulf

The favorable natural conditions and variety of habitats in the Beibu Gulf provide a basis for harboring a high diversity of marine organisms. Sustainable coastal ecosystem management can be benefited from a comprehensive assessment of species diversity. In this study, we analyzed the seasonal changes in nektonic phylogenetic and community structures in the waters of Weizhou Island in the northern Beibu Gulf. The results showed that both the nektonic phylogenetic diversity and community structure in the northern Beibu Gulf exhibited strong seasonal differences between spring and autumn. The catch density was 291.9 kg per km2 in spring and 1081.1 kg per km2 in autumn. Phylogenetic diversity of nektonic communities obviously increased from spring to autumn, while phylogenetic patterns changed from clustering to overdispersion. The seasonal patterns of nektonic communities were mainly related to the different fishing intensities in spring and autumn. Summer fishing intensity in the Beibu Gulf was effectively controlled by a mid-summer fishing moratorium, during which nektonic diversity and fish stocks rapidly recovered from the larval pool. Our study revealed that fishing intensity had a greater impact on nektonic communities at smaller spatial scales, and even exceeded the effects of environmental factors.