Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction structures between a child and two therapists in the psychodynamic treatment of a child with borderline personality disorder

This study examined the constellation of interaction structures – repetitive patterns of interactions between patient and therapist over the course of treatment – that emerged in the psychodynamic therapy (PDT) of a child diagnosed with borderline personality disorder and treated by two doctoral student therapists. Identification of these interaction structures can inform therapists of what might be expected from patients with particular symptom or behaviour patterns and how interactions change over time. This study also examined each session’s adherence to three session prototypes: PDT, cognitive-behavioural therapy (CBT) and reflective functioning (RF) process. The Child Psychotherapy Q-Set (CPQ) is a 100-item instrument that assesses the processes within a single psychotherapy session. Items reflect a wide range of therapist attitudes and behaviours, patient attitudes and behaviours and interactions between therapist and patient. Experts used the CPQ to define PDT, CBT and RF process session prototypes. The results suggested that four distinct interaction structures could be identified and that their constellations differed between the two therapists and also differed over time within each treatment. Therapists were more structured and accommodating early on in their treatments and more interpretive later. Prototypical PDT process was more prominent in the sessions than RF process, which in turn was more prominent than CBT process. Unique therapeutic processes are at work in every dyad, despite holding the patient and theoretical orientation constant. An effective treatment in one dyad might not work in another due to therapist-specific and dyad-specific effects.
Using precision teaching strategies to promote self-management of inner behaviours and measuring effects on the symptoms of depression

This study examined the use of precision teaching strategies to promote self-management of inner behaviours and measured the effect of these strategies on the symptoms of depression. Nine people in total participated in the study, three had minimal symptoms of depression, three had mild symptoms of depression and three had moderate symptoms of depression. Participants in the treatment group completed a BDI-II questionnaire, counted positive and negative thoughts throughout the day, participated in individualised interventions, before completing the BDI-II again and completing a social validity questionnaire. Participants in the control group 1 completed a BDI-II questionnaire, counted positive and negative thoughts throughout the day, completed the BDI-II again and completed a social validity questionnaire. Participants in the control group 2 completed a BDI-II questionnaire at the beginning and end of study and carried out a social validity questionnaire. The findings of this study demonstrate that the see/read fluency intervention was successful for all participants within the treatment group in increasing the frequency of positive thoughts whilst reducing the frequency of negative thoughts across the day. All participants within the treatment group had a reduction in their scores on the BDI-II from the beginning to the end of this study. Therefore an increase in the frequency of positive inner behaviours and a decrease in negative inner behaviours did correlate with a reduction in symptoms of depression for all participants within the treatment group.
EFFECTS OF AMINO ACID ANTAGONISTS ON SPONTANEOUS DORSAL ROOT ACTIVITY AND EVOKED DORSAL HORN FIELD POTENTIALS IN AN ISOLATED PREPARATION OF RAT SPINAL CORD

Fast and slow dorsal horn field potentials and spontaneous dorsal root activity were recorded from 19–23-day-old rat isolated spinal cord preparations. The effects of GABA, glycine, and glutamate antagonists were tested on these recordings. CNQX, an AMPA/kainate antagonist, reduced all 3 components of the dorsal horn field potential whereas MK801, an NMDA ion channel antagonist, reduced the fast S2 component and the slow wave. Both reduced spontaneous dorsal root activity. NMDA antagonists, D-AP5, 7-chlorokynurenic acid and arcaine, and the metabotropic glutamate antagonists L-AP3 and ethylglutamic acid, while having little effect on the fast components of the field potential, all reduced the slow component. The GABA antagonist, bicuculline, and the glycine antagonist, strychnine, while having no effect on the fast S1 and slow components of the field potential, reduced both the fast S2 component of the field potential and spontaneous dorsal root activity. These results suggest that non-NMDA glutamate receptors are involved in low and high threshold transmission to dorsal horn neurones while NMDA and metabotropic glutamate receptors are primarily involved in high threshold transmission and both GABA and glycine have roles in the transmission or modulation of sensory information within the dorsal horn of the cord.
H2O2‐induced block of glycolysis as an active ADP‐ribosylation reaction protecting cells from apoptosis

ABSTRACT H2O2 treatment on U937 cells leads to the block of glycolytic flux and the inactivation of glyceraldehyde‐3‐phosphate‐dehydrogenase by a posttranslational modification (possibly ADP‐ribosylation). Glycolysis spontaneously reactivates after 2 h of recovery from oxidative stress; thereafter cells begin to undergo apoptosis. The specific ADP‐ribosylation inhibitor 3‐aminobenzamide inhibits the stress‐induced inactivation of glyceraldehyde‐3‐phosphate‐dehydrogenase and the block of glycolysis; concomitantly, it anticipates and increases apoptosis. Exogenous block of glycolysis (i.e., by culture in glucose‐free medium or with glucose analogs or after NAD depletion), turns the transient block into a stable one: this results in protection from apoptosis, even when downstream cell metabolism is kept active by the addition of pyruvate. All this evidence indicates that the stress‐induced block of glycolysis is not the result of a passive oxidative damage, but rather an active cell reaction programmed via ADP‐ribosylation for cell self‐defense. —Colussi, C. , Albertini, M. C. , Coppola, S. , Rovidati, S. , Galli, F. , Ghibelli, L. H2O2‐induced block of glycolysis as an active ADP‐ribosylation reaction protecting cells from apoptosis. FASEB J. 14, 2266‐2276 (2000)
Editorial LA INTELIGENCIA EMOCIONAL COMO ESTRATEGIA DE PREVENCIÓN DE LAS ADICCIONES EMOTIONAL INTELLIGENCE AS AN ADDICTION PREVENTION STRATEGY

Resumen Behavioral addictions including Internet addiction still remaining in a scientific limbo because of the difficulties related to a properly differentiation between normal and pathological behaviors. Literature has conceptualized substance addiction in a comprehensive manner and now stands for define the behavioral addictions and their consequential abuse behaviors as a function of parameters related to use frequency, money invested, need or compulsion, as well as the interferences in people’s daily lives that may lead them to default on their obligations. As a consequence of the advent of the Social Networking Sites (SNS) and their wide impact among population we may find a new addiction context. These services in addition to their appealing and functionality have an easy connection everywhere at any time, which makes them powerful and immediately enhancers, becoming a breeding ground for an addiction. We are fully aware that is not possible to keep ahead to the technologies and neither their consequences but extra effort is still needed to understand their mechanisms, how can we predict the appearance among young people and how can we fight therapeutically against their consequences.
Transition System Semantics of DFL as a Scientific Workflow Language

Data-flow and control-flow perspectives are the most important perspectives to workflow management. As scientific workflows often operate on large, complex, and heterogeneous data, data-flow is particularly important to them. DFL is a formal, graphical workflow language for data-flows based on Petri nets and nested relational calculus. The focus of this paper is to articulate the transition system semantics of DFL. The major flaws of the existing work in terms of the transition system semantics lie in the following aspects, containing token unnesting history management, enabling configuration and state transition, are clearly revised. The following improvements can be obtained from revising those flaws: (1)The token unnesting history management is more efficient in terms of time and space. It can be increased when unnest edges lead to output places and be decreased when nest edges lead from input places. Empty sets are dealt with in coherence with non-empty sets to identify an enabling configuration. (2)The prerequisites of enabling configurations are complemented with that tokens in all input places of the firing transition have the same history and enable the transition. (3)The transition system semantics are clarified in detail on what tokens are consumed from and produced in which places.
Bloom's Revized Taxonomy and Critics on It

The aim of this study is to point out the reasons of and the critics about revised taxonomy which has been used since 1956 and was revised in 2001. Scanning method is used in this study. In the light of analysis of data collection, these results are obtained: 1. Reasons behind the revision of Bloom’s taxonomy are; being unable to respond with a one-dimensional form to the developments in educational psychology and learning approaches, having difficulty in evaluating owing to the cumulative hierarchical framework of original taxonomy, and being insufficient of one-dimensional form of Bloom’s taxonomy within the scope of cognitive processes. 2. Here are the main critics of the revised taxonomy; revised taxonomy brings terminological and structural innovations for the process of instructional planning, increased number of sub-categories contributes to phase of reading objectives, revised taxonomy makes it possible to use new concepts, such as performance and authentic assessment, there are different opinions about the two steps that are accepted as the most difficult and located at the top. The knowledge dimension and cognitive process dimension are understandable enough and there are difficulties regarding the use of the classification.
Schizophrenia and interference. An analogy with a malfunctioning computer.

THE SUBJECT of schizophrenia is responsible for a fast growing but increasingly indigestible mass of clinical descriptions and experiments. Many of these data are valuable, but some conceptual scheme for ordering and organizing these observations would be helpful. The obvious parallels between human thought processes and computer programs have inspired some useful models; thus, I was led to explore a computer analogy for schizophrenic thought-process disorder. Some years ago, before phenothiazines, a fire broke out on the back ward of a state hospital. Most of the patients were hallucinated, chronic, process schizophrenics. However, they quickly queued up and marched out as sane as you please. Mannerisms, responses to hallucinations, and other gross signs of disorder vanished until after they reached the safety of the yard; then things returned to normal, or, in this case, to abnormal. With such a clear
Selective Gαi Subunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels*

Background: Activation of TRPC4/5 channels is mediated by GPCR activation. Results: TRPC4/5 was activated by the Gαi/o-coupled receptor and the Gαi protein, which interacted directly with each other. Conclusion: Gαi proteins play an essential role as novel activators of TRPC4/5. Significance: Our findings provide new insights into the activation mechanism of inhibitory Gα proteins. The ubiquitous transient receptor potential canonical (TRPC) channels function as non-selective, Ca2+-permeable channels and mediate numerous cellular functions. It is commonly assumed that TRPC channels are activated by stimulation of Gαq-PLC-coupled receptors. However, whether the Gαq-PLC pathway is the main regulator of TRPC4/5 channels and how other Gα proteins may regulate these channels are poorly understood. We previously reported that TRPC4/TRPC5 can be activated by Gαi. In the current work, we found that Gαi subunits, rather than Gαq, are the primary and direct activators of TRPC4 and TRPC5. We report a novel molecular mechanism in which TRPC4 is activated by several Gαi subunits, most prominently by Gαi2, and TRPC5 is activated primarily by Gαi3. Activation of Gαi by the muscarinic M2 receptors or expression of the constitutively active Gαi mutants equally and fully activates the channels. Moreover, both TRPC4 and TRPC5 are activated by direct interaction of their conserved C-terminal SESTD (SEC14-like and spectrin-type domains) with the Gαi subunits. Two amino acids (lysine 715 and arginine 716) of the TRPC4 C terminus were identified by structural modeling as mediating the interaction with Gαi2. These findings indicate an essential role of Gαi proteins as novel activators for TRPC4/5 and reveal the molecular mechanism by which G-proteins activate the channels.
An Evaluation of a Threshold Theory for Personality Assessment

A model designed to account for major factors on personality questionnaires is proposed and evaluated using the Differential Personality Inventory (DPI). This model of the bases for stylistic responses to a set of personality items postulates two respondent processes: sensitivity to the underlying desirability scale values of items, and threshold for responding desirably. These processes correspond respectively to response style factors identified previously as desirability and acquiescence. A number of numerical indices of the two processes are evaluated factor analytically. When true- and false-keyed subscales of the DPI were factored the two major factors were marked respectively by measures of sensitivity and threshold. These results are similar to previous findings with the MMPI, except that for the DPI the stylistic factors accounted for only half as much variance.
Botanical tree structure modeling based on real image set

the growth model, which can construct a very natural tree structure. 1 However, this model makes it difficult to predict the final form of the tree given parameters; that is, if an objective form of a tree is given and it is to be reconstructed into a three-dimensional model, we have to change the parameters to reflect the structure by a trial-and-error technique. Thus, we propose a new top-down approach in which a tree's form is defined by volum data that is made from a captured real image set, and the branch structure is realized by simple branching rules. In this technique, some still color images of the target tree are first acquired with a video camera from different viewpoints , and unnecessary scene background is removed by manual operation. Image pre-processing involves four successive stages: normalizing trunk position and the tree size between each image, analyzing the color texture of branches and leaves, generating the color textures for the target tree, and color-to-gray-scale image conversion. A volume data construction process using the inverse reprojection method is performed for the gray-scale image. The volume data are defined as an object that fully contains the target tree and consists of voxels, each with a density value that corresponds to the pixel value in the original image. Simple branching rules then create the tree-branch structure within the volume data. The rules include a simple ternary branch model and some restrictions for expressing a general broadleaf tree. More specifically, a branch is formed by connecting branch segments that have cylindrical shapes, and a branch can split into a maximum of three directions. Special rules are not needed for each kind of tree because the form differences of various species can almost be represented from the volume data. The branching rules are controlled by the density distribution of voxels in the volume data and restrictions on the tree structure in creating a natural form. A branch basically extends in the direction of the largest density value in the volume data. For example, thick branches, a trunk, or an area thickly covered with leaves gives a large density value. It never extends to outside of the volume data. In addition, we apply some restrictions on the branching rules: avoid generating a hook-shaped branch, avoid generating a branch extended towards the ground, make branches extend from the trunk position as much as possible, and give higher …
Use of ICS/LABA (extra-fine and non-extra-fine) in elderly asthmatics

Age represents an exclusion criterion in randomized clinical trials designed to test the efficacy and safety of inhaled drugs in asthma. As a consequence, data on efficacy and safety of inhaled corticosteroid (ICS) and long-acting β2 agonist (LABA) combinations in elderly asthmatics are scanty. Older age is associated with an increased proportion of comorbid conditions; in addition, all organ functions undergo a process of senescence, thus reducing their ability to metabolize the agents. Overall, these age-associated conditions may variably, and often unpredictably, affect the metabolism and excretion of respiratory drugs. However, pharmacological treatment of asthma does not follow specific recommendations in the elderly. In the elderly, the ICS/LABA combinations may carry an increased risk of local indesiderable effects, primarily due to the lack of coordination between activation of the device and inhalation, and systemic adverse events, mainly due to the greater amount of active drug that is available because of the age-associated changes in organ functions as well as drug-to-drug and drug-to-concomitant disease interactions. The extra-fine formulations of ICSs/LABAs, which allow for a more favorable drug deposition in the lungs at a reduced dose, may contribute to overcome this issue. This review revises the efficacy and safety of treatment with ICSs/LABAs, focusing on the main pharmacodynamic and pharmacokinetic properties of the drugs and highlighting the potential risks in the elderly asthmatic population.
Multiple stellar populations in Magellanic Cloud clusters - I. An ordinary feature for intermediate age globulars in the LMC?

Context. The discovery of multiple main sequences (MS) in the massive clusters NGC 2808 and Omega Centauri, along with multiple subgiant branches in NGC 1851 and NGC 6388 has challenged the long-held paradigm that globular clusters consist of simple stellar populations. This evolving picture has been further complicated by recent photometric studies of the Large Magellanic Cloud (LMC) intermediate-age clusters, where the main sequence turn-off (MSTO) was found to be bimodal (NGC 1806 and NGC 1846) or broadened (NGC 1783 and NGC 2173). Aims. We undertook a study of archival HST images of Large and Small Magellanic Cloud clusters with the aim of measuring the frequency of clusters with evidence of multiple or prolonged star formation events and determining their main properties. We found useful images for 53 clusters that cover a wide range of ages. In this paper, we analyse the color-magnitude diagrams (CMD) of sixteen intermediate-age (~1–3 Gyr) LMC clusters. Methods. The data were reduced and the photometry corrected for differential reddening (where required). We find that eleven clusters show an anomalous spread (or split) in colour and magnitude around the MSTO, even though the other main features of the CMD (MS, red giant branch, asymptotic giant branch) are narrow and the horizontal branch (HB) red clump well defined. By using the CMD of the stars in regions that surround the cluster, we demonstrate that the observed feature is unequivocally associated to the clusters. We use artificial-star tests to demonstrate that the spread (or split) is not an artifact due to photometric errors or binaries. Results. We confirm that two clusters (NGC 1806 and NGC 1846) clearly exhibit two distinct MSTOs and observe, for the first time, a double MSTO in NGC 1751. In these three clusters, the population corresponding to the brighter MSTO includes more than two-thirds of the cluster stellar population. We confirm the presence of multiple stellar populations in NGC 1783. Our photometry strongly suggests that the MSTO of this cluster is formed by two distinct branches. In seven clusters (ESO057-SC075, HODGE7, NGC 1852, NGC 1917, NGC 1987, NGC 2108, and NGC 2154), we observed an intrinsic broadening of the MSTO that may suggest that these clusters have experienced a prolonged period of star formation that spans a period between 150 and 250 Myr. The CMDs of IC 2146, NGC 1644, NGC 1652, NGC 1795, and NGC 1978 show no evidence of spread or bimodality within our photometric precision. In summary, 70 ± 25% of our sample are not consistent with the simple, single stellar population hypothesis.
Thesaurus mapping: a challenge for ontology alignment?

Thesauri are hierarchical knowledge organization systems commonly used in libraries to categorize and index publications. While sometimes referred to as so-called lightweight ontologies [4], they actually fundamentally differ from ontologies in several aspects. Nevertheless, as thesauri are actively used, constantly maintained and improved, they offer an interesting background knowledge for semantic applications. This year, we reinstantiated the OAEI library track1, i.e., we provide the ontology matching community with the challenge to create alignments between thesauri. First, we aim for interesting insights into the differences between ontologies and thesauri. Second, we try to further integrate existing thesauri by means of new alignments which leads to better search experiences within library systems. From 2007 to 2009, there has already been a library track in the OAEI [1]. They focused on matching thesauri describing the same topic but at a different level of granularity. For our track, we selected two very comparable thesauri with topical overlaps. To make sure that the created alignments are indeed used, we work closely together with the maintaining institutions. We apply the following two thesauri:
An intelligent event-driven approach for efficient energy consumption in commercial buildings: smart office use case

In this paper we present a use case related to the intelligent processing of events coming from the conventional ("cheap") sensors in order to support better energy consumption in commercial buildings. The approach has been implemented using our iCEP framework and deployed in the office space of a real working environment. This research is a kind of the proof of the concept for a new technology that the industry partner would like to exploit. The results are very encouraging: smart decisions for the efficient usage of energy can be made by the intelligent processing of "cheap" sensor events.
Not So Naive Online Bayesian Spam Filter

Spam filtering, as a key problem in electronic communica- tion, has drawn significant attention due to increasingly huge amounts of junk email on the Internet. Content-based fil- tering is one reliable method in combating with spammers' changing tactics. Na¨ ive Bayes (NB) is one of the earliest content-based machine learning methods both in theory and practice in combating with spammers, which is easy to imple- ment while can achieve considerable accuracy. In this paper, the traditional online Bayesian classifier are enhanced by two ways. First, from theory's point of view, we devise a self- adaptive mechanism to gradually weaken the assumption of independence required by original NB in the online training process, and as a result of that our NSNB is no longer "na¨ive". Second, we propose other engineering ways to make the clas- sifier more robust and accuracy. The experiment results show that our NSNB does give state-of-the-art classification per- formance on online spam filtering on large benchmark data sets while it is extremely fast and takes up little memory in comparison with other statistical methods.