Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonlinear Commuted Synthesis of Bowed Strings

A commuted-synthesis model for bowed strings is driven by a separate nonlinear model of bowed-string dynamics. This gives the desirable combination of a full range of complex bow-string interaction behavior together with an efficiently implemented body resonator. A “single-hair bow” may control a pulsed-noise version which provide the effects of multiple bow hairs. The pulsed noise may also include qualitatively the impulse responses of commuted high-frequency body modes.
Physical plasticity of the nucleus in stem cell differentiation

Cell differentiation in embryogenesis involves extensive changes in gene expression structural reorganization within the nucleus, including chromatin condensation and nucleoprotein immobilization. We hypothesized that nuclei in naive stem cells would therefore prove to be physically plastic and also more pliable than nuclei in differentiated cells. Micromanipulation methods indeed show that nuclei in human embryonic stem cells are highly deformable and stiffen 6-fold through terminal differentiation, and that nuclei in human adult stem cells possess an intermediate stiffness and deform irreversibly. Because the nucleo-skeletal component Lamin A/C is not expressed in either type of stem cell, we knocked down Lamin A/C in human epithelial cells and measured a deformability similar to that of adult hematopoietic stem cells. Rheologically, lamin-deficient states prove to be the most fluid-like, especially within the first ≈10 sec of deformation. Nuclear distortions that persist longer than this are irreversible, and fluorescence-imaged microdeformation with photobleaching confirms that chromatin indeed flows, distends, and reorganizes while the lamina stretches. The rheological character of the nucleus is thus set largely by nucleoplasm/chromatin, whereas the extent of deformation is modulated by the lamina.
Self-Assembly and DNA Binding of the Blocking Factor in X Chromosome Inactivation

X chromosome inactivation (XCI) is the phenomenon occurring in female mammals whereby dosage compensation of X-linked genes is obtained by transcriptional silencing of one of their two X chromosomes, randomly chosen during early embryo development. The earliest steps of random X-inactivation, involving counting of the X chromosomes and choice of the active and inactive X, are still not understood. To explain “counting and choice,” the longstanding hypothesis is that a molecular complex, a “blocking factor” (BF), exists. The BF is present in a single copy and can randomly bind to just one X per cell which is protected from inactivation, as the second X is inactivated by default. In such a picture, the missing crucial step is to explain how the molecular complex is self-assembled, why only one is formed, and how it binds only one X. We answer these questions within the framework of a schematic Statistical Physics model, investigated by Monte Carlo computer simulations. We show that a single complex is assembled as a result of a thermodynamic process relying on a phase transition occurring in the system which spontaneously breaks the symmetry between the X's. We discuss, then, the BF interaction with X chromosomes. The thermodynamics of the mechanism that directs the two chromosomes to opposite fates could be, thus, clarified. The insights on the self-assembling and X binding properties of the BF are used to derive a quantitative scenario of biological implications describing current experimental evidences on “counting and choice. ”
Laser micro-milling under a thin and flowing water layer: A new concept of liquid-assisted laser machining process

This study proposes a new laser micro-milling technique for minimizing the thermal damage and gaining a higher material removal rate than using the laser alone. A low-pressure waterjet was used to impinge on the workpiece surface in order to form a thin water film, where the laser ablation was made underneath the water layer created. According to the findings, the presented technique can introduce a great reduction in heat-affected zone and significantly increase the cavity depth compared to the other laser milling processes. Experimental analyses and potential use of this new machining technique were also given and discussed.
Relationship analysis: a research plan for enhancing systems analysis for Web development

This research addresses a major shortcoming in today's analysis techniques. Neither structured nor object-oriented analysis techniques provide a formal process to identify relationships in a system being modeled. Existing techniques leave the relationship determination implicit; they are supposed to appear as a byproduct of the other analysis activities. We propose a comprehensive, systematic, domain-independent analysis technique, relationship analysis (RA), which focuses exclusively on a domain's relationship structure. RA serves two major purposes. First, it helps users, analysts and designers develop a deeper understanding of the application domain through making the relationships explicit. Second, RA results in fuller and richer application analyses and designs. Integration of RA with the object oriented analysis techniques like UP can provide a complete system architect solution.
Longitudinal Trends in Hypertension Management and Mortality Among Octogenarians

The role of hypertension management among octogenarians is controversial. In this long-term follow-up (>10 years) study, we estimated trends in hypertension prevalence, awareness, treatment, and control among octogenarians, and evaluated the relationship of systolic blood pressure (SBP) ranges with mortality. Data were based on the English Longitudinal Study of Ageing (ELSA). Outcome measures were hypertension prevalence, awareness, treatment and control, and cardiovascular disease, and all-cause mortality events. Participants were separated into 8 categories of SBP values (<110, 110–119, 120–129, 130–139, 140–149, 150–159, 160–169, and >169 mm Hg). Among 2692 octogenarians, mean SBP levels declined from 147 mm Hg in 1998/2000 to 134 mm Hg in 2012/2013. The decline was of lower magnitude in the 50 to 79 years old subgroup (n=22007). Hypertension prevalence and awareness were 40% and 13%, respectively, higher among octogenarians than the 50 to 79 years of age subgroup, but hypertension treatment rates were similar (≈90%). Around 47% of the treated octogenarians achieved conventional BP targets (<140/90 mm Hg), increasing to 59% when assessed against revised targets (<150/90 mm Hg). All-cause mortality rates were higher (hazard ratio, 1.55; 95% confidence interval, 0.89–2.72) at lower extremes of SBP values (<110 mm Hg). The lowest cardiovascular disease and all-cause mortality risk among treated octogenarians was observed for an SBP range of 140 to 149 mm Hg (1.04, 0.60–1.78) and 160 to 169 mm Hg (0.78, 0.51–1.21). An increasing trend in hypertension awareness and treatment was observed in a large sample of community-dwelling octogenarians. The results do not support the view that more stringent BP targets may be associated with lower mortality.
Chernoff-Hoeffding bounds for applications with limited independence

Chernoff-Hoeffding (CH) bounds are fundamental tools used in bounding the tail probabilities of the sums of bounded and independent random variables (r.v.'s). We present a simple technique that gives slightly better bounds than these and that more importantly requires only limited independence among the random variables, thereby importing a variety of standard results to the case of limited independence for free. Additional methods are also presented, and the aggregate results are sharp and provide a better understanding of the proof techniques behind these bounds. These results also yield improved bounds for various tail probability distributions and enable improved approximation algorithms for jobshop scheduling. The limited independence result implies that a reduced amount and weaker sources of randomness are sufficient for randomized algorithms whose analyses use the CH bounds, e.g., the analysis of randomized algorithms for random sampling and oblivious packet routing.
Runtime verification of nonlinear analog circuits using incremental Time-augmented RRT algorithm

Because of complexity of analog circuits, their verification presents many challenges. We propose a runtime verification algorithm to verify design properties of nonlinear analog circuits. Our algorithm is based on performing exploratory simulations in the state-time space using the Time-augmented Rapidly Exploring Random Tree (TRRT) algorithm. The proposed runtime verification methodology consists of i) incremental construction of the TRRT to explore the state-time space and ii) use of an incremental online monitoring algorithm to check whether or not the incremented TRRT satisfies or violates specification properties at each iteration. In comparison to the Monte Carlo simulations, for providing the same state-space coverage, we utilize a logarithmic order of memory and time.
Reconstituting a Human Brain in Animals: A Jewish Perspective on Human Sanctity

The potential use of stem cells in the treatment of a variety of human diseases has been a major driving force for embryonic stem cell research. Another productive area of research has been the use of human stem cells to reconstitute human organ systems in animals in an attempt to create new animal models for human diseases. However, the possibility of transplanting human embryonic brain cells or precursor brain cells into an animal fetus presents numerous ethical challenges. This paper examines, from a Jewish perspective on human dignity, several bioethical concerns related to the reconstitution of animal brains with human neurons.
Electroactive and large area V2O5 film prepared via ultrasonic spraying

Vanadium pentoxide films have been synthesized by ultrasonic spraying using self-fabricated equipment. Experimental condition is easy to control without the presence of high temperature, electric field, and vacuum. The substrate on which the film deposits does not require high conductivity and the obtained film is good in uniformity. The method is especially effective to process large area films. In this study, the obtained films were investigated for their structural, surface morphological, electrochemical and optical properties. Compared with electrodeposited vanadium pentoxide films, sprayed ones exhibit relatively poor charge storage capacity, but a similar transmittance value. Under comprehensive consideration, the ultrasonic spraying method is preponderant choice for preparing large area films for electrochromic devices.
An evidence-theoretic k-NN rule with parameter optimization

The paper presents a learning procedure for optimizing the parameters in the evidence-theoretic k-nearest neighbor rule, a pattern classification method based on the Dempster-Shafer theory of belief functions. In this approach, each neighbor of a pattern to be classified is considered as an item of evidence supporting certain hypotheses concerning the class membership of that pattern. Based on this evidence, basic belief masses are assigned to each subset of the set of classes. Such masses are obtained for each of the k-nearest neighbors of the pattern under consideration and aggregated using Dempster's rule of combination. In many situations, this method was found experimentally to yield lower error rates than other methods using the same information. However, the problem of tuning the parameters of the classification rule was so far unresolved. The authors determine optimal or near-optimal parameter values from the data by minimizing an error function. This refinement of the original method is shown experimentally to result in substantial improvement of classification accuracy.
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder

Background Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to the development of depression (major depressive disorder, MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD. Aims To investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions. Method Magnetic resonance imaging scans were acquired in 79 persons with MDD (mean age 49 years) and 74 healthy volunteers (mean age 50 years). Effects on surface area and cortical thickness were examined with multiple comparison correction. Results People who were Met allele carriers showed reduced caudal middle frontal thickness in both study groups. Significant interaction effects were found in the anterior cingulate and rostral middle frontal regions, in which participants in the MDD group who were Met carriers showed the greatest reduction in surface area. Conclusions Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
Spatio-temporal conceptual models: data structures + space + time

Nowadays, many applications need data modeling facilities for the description of complex objects with spatial and/or temporal facilities. Responses to such requirements may be found in Geographic Information Systems (GIS), in some DBMS, or in the research literature. However, most of existing models cover only partly the requirements (they address either spatial or temporal modeling), and most are at the logical level, hence not well suited for database design. This paper proposes a spatio-temporal modeling approach at the conceptual level, called MADS. The proposal stems from the identification of the criteria to be met for a conceptual model. It is advocated that orthogonality is the key issue for achieving a powerful and intuitive conceptual model. Thus, the proposal focuses on highlighting similarities in the modeling of space and time, which enhance readability and understandability of the model.
A Handsome Set of Metrics to Measure Utterance Classification Performance in Spoken Dialog Systems

We present a set of metrics describing classification performance for individual contexts of a spoken dialog system as well as for the entire system. We show how these metrics can be used to train and tune system components and how they are related to Caller Experience, a subjective measure describing how well a caller was treated by the dialog system.
Sherali-Adams Gaps, Flow-cover Inequalities and Generalized Configurations for Capacity-constrained Facility Location

Metric facility location is a well-studied problem for which linear programming methods have been used with great success in deriving approximation algorithms. The capacity-constrained generalizations, such as capacitated facility location (CFL) and lower-bounded facility location (LBFL), have proved notorious as far as LP-based approximation is concerned: while there are local-search-based constant-factor approximations, there is no known linear relaxation with constant integrality gap. According to Williamson and Shmoys devising a relaxation-based approximation for CFL is among the top 10 open problems in approximation algorithms. This paper advances significantly the state-of-the-art on the effectiveness of linear programming for capacity-constrained facility location through a host of impossibility results for both CFL and LBFL. We show that the relaxations obtained from the natural LP at Omega(n) levels of the Sherali-Adams hierarchy have an unbounded gap, partially answering an open question from the literature. Here, n denotes the number of facilities in the instance. Building on the ideas for this result, we prove that the standard CFL relaxation enriched with the generalized flow-cover valid inequalities has also an unbounded gap. This disproves a long-standing conjecture of Levi et al. We finally introduce the family of proper relaxations which generalizes to its logical extreme the classic star relaxation and captures general configuration-style LPs. We characterize the behavior of proper relaxations for CFL and LBFL through a sharp threshold phenomenon.
Discrete-Time Positive Periodic Systems With State and Control Constraints

The aim of this technical note is to provide an efficient control design technique for discrete-time positive periodic systems. In particular, stability, positivity and periodic invariance of such systems are studied. Moreover, the concept of periodic invariance with respect to a collection of boxes is introduced and investigated with connection to stability. It is shown how such concept can be used for deriving a stabilizing state-feedback control that maintains the positivity of the closed-loop system and respects states and control signals constraints. In addition, all the proposed results can be efficiently solved in terms of linear programming.
WALLERIAN DEGENERATION: A SEQUENTIAL PROCESS

—A study of Wallerian degeneration as a function of time has indicated that the degenerative process is sequential, that it begins with myelin that was laid down last and progresses toward myelin that was laid down first. It is proposed that Wallerian degeneration is a relatively poor model for the study of degeneration of nervous tissue in many pathological conditions.
How to Write a Visualization Research Paper: A Starting Point

This paper attempts to explain the mechanics of writing a research paper in visualization. This serves as a useful starting point for those who have never written a research paper before or have very little previous experience. After all, no one is born knowing how to write one. And yet, there are certain elements, a commonality, that should be found in virtually all good visualization research papers. We give our recommendations as to each section a good research paper consists of as well as what each section contains. This paper itself follows our recommended structure.
Continuous ambulatory peritoneal dialysis as a therapeutic alternative in patients with advanced congestive heart failure

Continuous ambulatory peritoneal dialysis (CAPD) has been proposed as an additional therapeutic resource for patients with advanced congestive heart failure (CHF). The objective of this study was to determine the therapeutic role of CAPD, in terms of surrogate endpoints, in the management of patients with advanced CHF and renal dysfunction.
Management Guidelines & Operational Requirements for the Address and Routing Parameter Area Domain ("arpa")

This memo describes the management and operational requirements for the address and routing parameter area ("arpa") domain. The "arpa" domain is used to support a class of infrastructural identifier spaces, providing a distributed database that translates elements of a structured name space derived from a protocol family to service names. The efficient and reliable operation of this DNS space is essential to the integrity of operation of various services within the Internet. The Internet Architecture Board (IAB) has the responsibility, in cooperation with the Internet Corporation for Assigned Names and Numbers (ICANN), to manage the "arpa" domain. This document describes the principles used by the IAB in undertaking this role.
The East Side Village Health Worker Partnership: Integrating Research with Action to Reduce Health Disparities

This article describes the work of the East Side Village Health Worker Partnership as a case study of an initiative that seeks to reduce the disproportionate health risks experienced by residents of Detroit's east side. The Partnership is a community-based participatory research and intervention collaboration among academia, public health practitioners, and the east side Detroit community. The Partnership is guided by a steering committee that is actively involved in all aspects of the research, intervention, and dissemination process, made up of representatives of five community-based organizations, residents of Detroit's east side, the local health department, a managed care provider, and an academic institution. The major goal of the East Side Village Health Worker Partnership is to address the social determinants of health on Detroit's east side, using a lay health advisor intervention approach. Data collected from 1996 to 2001 are used here to describe improvements in research methods, practice activities, and community relationships that emerged through this academic-practice-community linkage.
Analysis of factors associated with traffic injury severity on rural roads in Iran

Abstract: Background: Iran is a country with one of the highest rates of traffic crash fatality and injury, and seventy percent of these fatalities happen on rural roads. The objective of this study is to identify the significant factors influencing injury severity among drivers involved in crashes on two kinds of major rural roads in Iran: two-lane, two-way roads and freeways. Methods: According to the dataset, 213569 drivers were involved in rural road crashes in Iran, over the 3 years from 2006 to 2008. The Classification And Regression Tree method (CART) was applied for 13 independent variables, and one target variable of injury severity with 3 classes of no-injury, injury and fatality. Some of the independent variables were cause of crash, collision type, weather conditions, road surface conditions, driver's age and gender and seat belt usage. The CART model was trained by 70% of these data, and tested with the rest. Results: It was indicated that seat belt use is the most important safety factor for two-lane, two-way rural roads, but on freeways, the importance of this variable is less. Cause of crash, also turned out to be the next most important variable. The results showed that for two-lane, two-way rural roads, "improper overtaking" and "speeding", and for rural freeways, "inattention to traffic ahead", "vehicle defect", and "movement of pedestrians, livestock and unauthorized vehicles on freeways" are the most serious causes of increasing injury severity. Conclusions: The analysis results revealed seat belt use, cause of crash and collision type as the most important variables influencing the injury severity of traffic crashes. To deal with these problems, intensifying police enforcement by means of mobile patrol vehicles, constructing overtaking lanes where necessary, and prohibiting the crossing of pedestrians and livestock and the driving of unauthorized vehicles on freeways are necessary. Moreover, creating a rumble strip on the two edges of roads, and paying attention to the design consistency of roads can be a helpful factor in order to prevent events such as "overturning" and improve the overall safety of freeways.