Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulating a patient's fall as a means to improve routine communication: Joint training for nursing and fifth-year medical students

Background: Physicians and nursing staff interact as a team on a daily basis in hospital settings. However, both educational paths offer few opportunities to establish contact with the other professional group. Neither professional group can practice its later role with the other group in a “safe” learning environment. Routine interprofessional collaboration is described as being in need of great improvement and carries with it the potential for conflict. To improve interprofessional communication and task management, a simulation-based emergency training session for nursing students and fifth-year medical students was developed at the KRH Klinikum Nordstadt in Hanover, Germany. As a pilot project, the course was held twice in the form of a one-day session with ten nursing and four medical students. Project: Using the example of a patient’s fall, course participants were able to observe and actively treat multiple simulated patients. Following each simulation the trainer conducted a comprehensive debriefing. The course was then evaluated using a questionnaire. Results: The evaluation of the team training showed a high level of acceptance among the two participating professional groups. On a scale of 1 (hardly applicable) to 5 (strongly applicable), the course was given a 4 by both professional groups for its relevance to daily work. In the open-ended written responses praise was specifically given for the opportunity to learn how to switch perspectives as a result of the simulation exercises. Conclusion: A common emergency on the hospital ward offers a good opportunity to establish and practice interprofessional team skills. With the knowledge gained about communication and the ability to change viewpoints, participants are able to improve their team skills. Participants demonstrated a high degree of acceptance for the training program.
A centralized scheduling algorithm for IEEE 802.15.4e TSCH based industrial low power wireless networks

Time-Slotted Channel Hopping (TSCH) is a part of an emerging IEEE 802.15. 4e standard to enable deterministic low-power mesh networking. It promises to pave the way to the future Internet of (Important) things by offering high reliability and low latency for wireless industrial applications. Nonetheless, the standard only provides a framework but it does not mandate a specific scheduling mechanism. In this paper, we propose a centralized Adaptive MUlti-hop Scheduling method (AMUS) based on the latest TSCH MAC. AMUS first enables sequential multi-hop scheduling to provide low latency guarantee for time-critical applications. Secondly, the novel tentative cell allocation method allocates additional resources to vulnerable links such that possible MAC retransmissions can be accommodated within the same slotframe, hence significantly reducing the delay caused by interference or collisions. Last but not least, the battery power of the node can be further conserved by adopting the proposed End-of-Q notification mechanism. Preliminary simulation results have confirmed that AMUS outperforms other popular scheduling algorithms in the literature.
SSTR-RADS Version 1.0 as a Reporting System for SSTR PET Imaging and Selection of Potential PRRT Candidates: A Proposed Standardization Framework

Reliable standards and criteria for somatostatin receptor (SSTR) PET are still lacking. We herein propose a structured reporting system on a 5-point scale for SSTR PET imaging, titled SSTR-RADS version 1.0, which might serve as a standardized assessment for both diagnosis and treatment planning in neuroendocrine tumors. SSTR-RADS could guide the imaging specialist in interpreting SSTR PET scans, facilitate communication with the referring clinician so that appropriate workup for equivocal findings is pursued, and serve as a reliable tool for patient selection for planned peptide receptor radionuclide therapy.
Burden of illness in patients with treatment refractory myasthenia gravis

Introduction: This study assessed the clinical burden of refractory myasthenia gravis (MG), relative to nonrefractory MG. Methods: Rates of myasthenic crises, exacerbations, inpatient hospitalizations, and emergency room (ER) visits over a 1‐year period were measured for 403 refractory, 3,811 nonrefractory, and 403 non‐MG control patients from two administrative health plan databases. Results: Compared with nonrefractory patients, a significantly greater percentage of refractory patients had at least one myasthenic crisis (21.3% vs. 6.1%; P < 0.001) and at least one exacerbation (71.2% vs. 32.4%; P < 0.001) over a 1‐year period. Refractory patients were also significantly more likely to be hospitalized and/or have an ER visit than nonrefractory patients and non‐MG controls (P < 0.001 for all). Discussion: Refractory MG patients have significantly greater clinical burden and are more likely to utilize intensive healthcare resources than nonrefractory patients. Furthermore, refractory patients may be at greater risk of crises throughout the disease course than previous studies have suggested. Muscle Nerve 58: 99–105, 2018
Elastic properties of single-wall nanotubes

We report the Young's modulus of a series single-wall carbon nanotubes(armchair type and zigzag type)and BN zigzag type nanotubes on the basis of ab initio theory. According to the calculations, the relation between Young's modulus and the diameter of nanotubes is presented. We have also discussed how the strain energy of rolling effect of all kinds of nanotubes and how the balance basis set a of nanotubes varies with the type of nanotubes.
A proposal for analogue cum digital character recognition.

An analogue-digital device for the recognition of hand printed capital block letters and numerals is proposed. The unknown characters are projected onto a grid of photo­ diodes. The edges and corners of the character are then emphasized by a detail filter and the output voltages of the diodes are normalized. Each of the 36 characters is placed in one of four subsets to reduce the number of samples required for identification. Then the characters are examined for the presence or absence of eighteen characteristics. Up to this stage the operation has been analogue in nature but since a large memory capacity is required the operation is transferred to an on-line digital computer. The computer operates on the above information. The analogue signals are quantized and codes for each character are established during the learning phase of the computer programme. During the testing or identification stage the computer programme employs three criteria to identify the unknown presented on the grid.of photo-diodes.
Malignancies and High Birth Weight in Human: Which Cancers Could Result from Antagonistic Pleiotropy?

Persistence of cancer over evolutionary times is a challenging question for scientists. We explored here the idea that cancer might result from negative trade- offs of adaptations that improve early survival and/or reproductive fitness. We focused on birth weight since this life history trait has a genetic basis and is also associated with fitness benefits early in life, especially survival. Our analysis includes 107 to 109 countries, 46 types of cancer and various potentially confounding variables. High birth weight was associated with an elevated incidence of ten cancers: kidney cancer, melanoma, multiple myeloma and pancreatic cancer, all four in both men and women, plus prostate and bladder cancers in men. These results, though correlational, suggest that antagonistic pleiotropy should be investigated further as a possible mechanism involved in the causation of cancer in humans.
Determination of Trace Elements by ICP-MS from Dentine Teeth Caries

Teeth are good indicators for exposure to heavy metals and for evaluation of nutritional status. To determine the trace elements in carious dentin of permanent teeth we have used inductively coupled plasma with mass spectrometry (ICP-MS). For this purpose, there were collected permanent teeth decayed (premolars and molars) from adults (men), aged 40 to 60 years old (N = 30), in 3 different areas: 10 samples from the Câmpia Turzii area (CT area exposed to Pb), 10 samples from the area of Satu-Mare (SM area exposed to Pb) and 10 samples collected from Cluj-Napoca (control group CJ). We have analyzed the concentrations of 8 elements (macroelements, trace elements and heavy metals: Ca, Mg, Cu, Fe, Zn, Mn, Cd, and Pb) in the dentin of permanent carious teeth. The concentrations of Fe, Zn, Mn, Mg, Cd and Pb were higher in carious permanent teeth from exposed subjects comparing with the control group CJ. Cu and Zn levels are higher in CT group. According to these results, we can conclude that trace elements and heavy metals are positively associated with caries. The concentrations of trace elements found in teeth often provide information about disability or illness, poisoning or contamination.
Relationship of polymorphisms and haplotype in interleukin-16 and adiponectin gene with late-onset Alzheimer’s disease risk

Aims To investigate the impact of Interleukin-16 (IL- 16) and Adiponectin (ANP) gene single nucleotide polymorphisms (SNPs), gene- gene interactions and haplotype on late-onset Alzheimer’s disease (LOAD) risk. Methods Hardy-Weinberg equilibrium (HWE), haplotype and pairwise linkage disequilibrium (LD) analysis were investigated by using SNPstats (available online at http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to examine interaction among 4 SNPs, odds ratio (OR) and 95% confident interval (95%CI) were calculated by logistic regression model. Results LOAD risk was significantly higher in carriers of rs266729- G allele than those with CC genotype (CG+ GG versus CC), OR (95%CI) =1.61 (1.26-1.96), and higher in carriers of rs1501299- T allele, OR (95%CI) = 1.62 (1.32-2.12), lower in carriers of rs4072111- T allele, adjusted OR (95%CI) =0.65 (0.44-0.93). We also found a significant gene- gene interaction between rs266729 and rs4072111. Participants with CG or GG of rs266729 and CC of rs4072111 genotype have the highest LOAD risk, OR (95%CI) = 2.62 (1.64 -3.58). Haplotype containing the rs266729- G and rs1501299- T alleles were associated with increased LOAD risk, OR (95%CI)= 1.83 (1.32- 2.43), and haplotype containing the rs1131445- C and rs4072111- T alleles were associated with decreased LOAD risk, OR (95%CI)= 0.53 (0.18- 0.95). Conclusions We concluded that rs266729 and rs1501299 minor alleles were associated with increased LOAD risk, but rs4072111 minor allele was associated with decreased LOAD risk. We also found that interaction involving rs266729 and rs4072111, and haplotype combinations were associated with LOAD risk.
Algal blooms , circulators , waterfowl , and eutrophic

Algal blooms, circulators, waterfowl, and eutrophic Greenfield Lake, North Carolina Michael A. Mallin, Matthew R. McIver, Ellen J. Wambach & Anna R. Robuck To cite this article: Michael A. Mallin, Matthew R. McIver, Ellen J. Wambach & Anna R. Robuck (2016) Algal blooms, circulators, waterfowl, and eutrophic Greenfield Lake, North Carolina, Lake and Reservoir Management, 32:2, 168-181, DOI: 10.1080/10402381.2016. 1146374 To link to this article: http://dx.doi. org/10.1080/10402381.2016. 1146374
Cardiac Sympathetic Denervation Can Predict the Wearing-off Phenomenon in Patients with Parkinson Disease

Recent studies have suggested that preserved cardiac sympathetic denervation may be associated with a small motor burden in Parkinson disease (PD) and serve as a good marker, which is not associated with other nonmotor symptoms. We sought to investigate whether cardiac sympathetic denervation increases the risk of the early wearing-off phenomenon in PD. Methods: This hospital-based prospective study enrolled 266 de novo patients with PD who underwent 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy on initial evaluation. The patients visited the outpatient clinic every 2–6 mo and were followed for a minimum of 18 mo from the time they began taking dopaminergic medication. Each patient was assessed for the wearing-off phenomenon on the basis of the clinical assessments and symptom diaries. Clinical events were analyzed from the date of evaluation by 123I-MIBG scintigraphy until the date of the first occurrence of the wearing-off phenomenon, or until the last follow-up date without wearing-off. Results: During a mean follow-up period of 30.4 ± 14.8 mo, 71 patients developed wearing-off. The wearing-off phenomenon occurred more in patients with decreased 123I-MIBG uptake. A Cox regression analysis revealed that both low 123I-MIBG uptake and early onset age significantly predicted the development of wearing-off. Conclusion: Our study suggests that a reduction in myocardial 123I-MIBG uptake in PD patients may be associated with a subsequent increased risk for the wearing-off phenomenon. Findings strongly support that PD patients with normal cardiac sympathetic innervation might have less involvement of the midbrain dopaminergic circuitry and a concomitant reduced risk for motor complications, such as wearing-off.
The effectiveness of various irrigation protocols on organic tissue removal from simulated internal resorption defects

AIM To evaluate the effectiveness of NaOCl, NaOCl-EDTA and NaOCl + HEBP activated by ultrasonics and XP-endo Finisher on organic tissue removal from simulated internal root resorption cavities. METHODOLOGY The root canals of 144 single-rooted teeth were instrumented. The teeth were split longitudinally, and semicircular cavities were prepared in the canal walls on each half of the roots. Samples obtained from ground bovine muscle tissue were weighed and adapted into the semicircular cavities. The root fragments were reassembled and cemented to create a circular simulated resorption cavity within the canal. Teeth were divided into twelve groups (n = 12) according to the irrigation protocols: group 1: NaOCl, no activation; group 2: NaOCl, passive ultrasonic irrigation (PUI); group 3: NaOCl, XP-endo Finisher; group 4: NaOCl-EDTA, no activation; group 5: NaOCl-EDTA, PUI; group 6: NaOCl-EDTA, XP-endo Finisher; group 7: NaOCl + HEBP, no activation; group 8: NaOCl + HEBP, PUI; group 9: NaOCl + HEBP, XP-endo Finisher; group 10: distilled water, no activation; group 11: distilled water, PUI; and group 12: distilled water, XP-endo Finisher. The teeth were disassembled, and the tissue remaining inside the resorption cavities were weighed. The data were analysed statistically using two-way anova and Fisher's LSD tests with a significance level of 0.05. RESULTS The use of XP-endo Finisher with the experimental solutions resulted in the greatest tissue weight loss compared to the other activation protocols (P < 0.001). There was no significant difference between NaOCl and NaOCl + HEBP in terms of tissue removal. CONCLUSION The use of a NaOCl + HEBP mixture activated with XP-endo Finisher was an effective irrigation regimen for removing simulated organic tissues from artificial internal root resorption cavities in the straight root canals of single-rooted teeth.
A study on path planning for small mobile robot to move in forest area

We are developing an autonomous monitoring system using mobile robot in response to the demands of autonomous monitoring in forest area. The effective path planning is required for autonomous operation. The robot needs to locomote in the grassy area so as to move in a natural forest area, therefore the path route on grassy area have to be considered. The objective of this study was to develop a path planning method for small mobile robot to move in the forest. We focused on the cost used to generate the path and try to add grass vegetation into the cost map. The grass vegetation degree is effective to generate the optimal path, and the robot could move in forest by following the generated path.
A STUDY ON THE MIGRATION OF STYRENE FROM POLYSTYRENE CUPS TO DRINKS USING ONLINE SOLID-PHASE EXTRACTION LIQUID CHROMATOGRAPHY (SPE-LC) (Kajian Mengenai Migrasi Stirena daripada Cawan Polistirena kepada Minuman Menggunakan Teknik Ekstraksi Fasa Pepejal Kromatografi Cecair (SPE-LC))

The migration of residual styrene from polystyrene cups to drinks has been a major concern in recent years worldwide. In this study, a three-factor response surface experimental design was used to evaluate the interactive effects of temperature (30-80 oC), pH (5-7) and contact time (35-120 min) on the migration of styrene from polystyrene cups into water. Online solid-phase extraction liquid chromatography (SPE-LC) with diode array detector (DAD) was used for the separation and detection of styrene. Initial temperature of water was found significant in increasing the rate of migration of styrene whereas the effect of contact time was less significant. In terms of interactions between the effects, the relation between temperature and pH was the most significant. The amount of styrene in water varied from 0.3 to 4.2 μg/L with maximum migration obtained at initial water temperature of 80 °C and pH 5.
Discriminating between copers and people with chronic ankle instability.

CONTEXT Differences in various outcome measures have been identified between people who have sprained their ankles but have no residual symptoms (copers) and people with chronic ankle instability (CAI). However, the diagnostic utility of the reported outcome measures has rarely been determined. Identifying outcome measures capable of predicting who is less likely to develop CAI could improve rehabilitation protocols and increase the efficiency of these measures. OBJECTIVE To determine the diagnostic utility and cutoff scores of perceptual, mechanical, and sensorimotor outcome measures between copers and people with CAI by using receiver operating characteristic curves. DESIGN Case-control study. SETTING Sports medicine research laboratory. PATIENTS OR OTHER PARTICIPANTS Twenty-four copers (12 men, 12 women; age = 20.8 ± 1.5 years, height = 173 ± 11 cm, mass = 78 ± 27 kg) and 24 people with CAI (12 men, 12 women; age = 21.7 ± 2.8 years, height = 175 ± 13 cm, mass = 71 ± 13 kg) participated. INTERVENTION(S) Self-reported disability questionnaires, radiographic images, and a single-legged hop stabilization test. MAIN OUTCOME MEASURE(S) Perceptual outcomes included scores on the Foot and Ankle Disability Index (FADI), FADI-Sport, and a self-report questionnaire of ankle function. Mechanically, talar position was quantified by measuring the distance from the anterior tibia to the anterior talus in the sagittal plane. Sensorimotor outcomes were the dynamic postural stability index and directional indices, which were calculated during a single-legged hop stabilization task. RESULTS Perceptual outcomes demonstrated diagnostic accuracy (range, 0.79-0.91), with 95% confidence intervals ranging from 0.65 to 1.00. Sensorimotor outcomes also were able to discriminate between copers and people with CAI but with less accuracy (range, 0.69-0.70), with 95% confidence intervals ranging from 0.37 to 0.86. The mechanical outcome demonstrated poor diagnostic accuracy (0.52). CONCLUSIONS The greatest diagnostic utility scores were achieved by the self-assessed disability questionnaires, which indicated that perceptual outcomes had the greatest ability to accurately predict people who became copers after their initial injuries. However, the diversity of outcome measures that discriminated between copers and people with CAI indicated that the causal mechanism of CAI is probably multifactorial.
An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons

Regulatory Factor X (RFX) transcription factors (TFs) are best known for activating genes required for ciliogenesis in both vertebrates and invertebrates. In humans, eight RFX TFs have a variety of tissue-specific functions, while in the worm Caenorhabditis elegans, the sole RFX gene, daf-19, encodes a set of nested isoforms. Null alleles of daf-19 confer pleiotropic effects including altered development with a dauer constitutive phenotype, complete absence of cilia and ciliary proteins, and defects in synaptic protein maintenance. We sought to identify RFX/daf-19 target genes associated with neuronal functions other than ciliogenesis using comparative transcriptome analyses at different life stages of the worm. Subsequent characterization of gene expression patterns revealed one set of genes activated in the presence of DAF-19 in ciliated sensory neurons, whose activation requires the daf-19c isoform, also required for ciliogenesis. A second set of genes is downregulated in the presence of DAF-19, primarily in nonsensory neurons. The human orthologs of some of these neuronal genes are associated with human diseases. We report the novel finding that daf-19a is directly or indirectly responsible for downregulation of these neuronal genes in C. elegans by characterizing a new mutation affecting the daf-19a isoform (tm5562) and not associated with ciliogenesis, but which confers synaptic and behavioral defects. Thus, we have identified a new regulatory role for RFX TFs in the nervous system. The new daf-19 candidate target genes we have identified by transcriptomics will serve to uncover the molecular underpinnings of the pleiotropic effects that daf-19 exerts on nervous system function.
SEARCHING FOR MINIMUM IN NEURAL NETWORKS

Neural networks are often characterized as highly nonlinear systems of fairly large amount of parameters (in order of 103 - 104 ). This fact makes the optimization of parameters to be a nontrivial problem. But the astonishing moment is that the local optimization technique is widely used and yields reliable convergence in many cases. Obviously, the optimization of neu­ ral networks is high-dimensional, multi-extremal problem, so, as usual, the global optimization methods would be applied in this case. On the basis of Perceptron-like'i unit (which is the building block for the most architectures of neural networks) we analyze why the local optimization technique is so successful in the field of neural networks. The result is that a linear approximation of the neural network can be sufficient to evaluate the start point for the local optimization procedure in the nonlinear regime. This result can help in developing faster and more robust algorithms for the optimization of neural network parameters.