Miracle-dz/UniFAR-FTUs huggingface dataset:
Intra‐ and Inter‐rater Reliability of Navigated Ultrasound in the Assessment of Pelvic Tilt in Symptom‐Free Young Adults

Pelvic tilt is the angle between the anterior pelvic plane and the coronal plane. It affects cup positioning in total hip arthroplasty. The primary objective of this study was to test the intra‐ and inter‐rater reliability of a navigated smart device–based ultrasound system for pelvic tilt assessment. The secondary objective was to test the inter‐rater variability of the measurements on a hip phantom.
Mutations in myeloproliferative neoplasms – their significance and clinical use

ABSTRACT Introduction: Clonal hematologic diseases of the blood such as polycythemia vera, essential thrombocythemia and primary myelofibrosis belong to the BCR-ABL negative Myeloproliferative Neoplasms (MPN). These diseases are characterized by clonal expansion of hematopoietic precursor cells followed by increased production of differentiated cells of the myeloid lineage. Initiation of clonal hematopoiesis, formation of a clinical phenotype as well as disease progression form part of MPN disease evolution. The disease is driven by acquired somatic mutations in critical pathways such as cytokine signaling, epigenetic regulation, RNA splicing, and transcription factor signaling. Areas covered: The following review aims to provide an overview of the mutational landscape of MPN, the impact of these mutations in MPN pathogenesis as well as their prognostic value. Finally, a summary of how these mutations are being used or could potentially be used for the treatment of MPN patients is presented. Expert commentary: The genetic landscape of MPN patients has been successfully dissected within the past years with the advent of new sequencing technologies. Integrating the genetic information within a clinical setting is already benefitting patients in terms of disease monitoring and prognostic information of disease progression but will be further intensified within the next years.
Modeling the Effect of ARC and other Parameters on the Efficiency of GaAs Solar Cell Using Silvaco

Gallium Arsenide (GaAs) based solar cell which have nearly ideal direct bandgap of 1.43eV hold the highest single junction solar cell efficiency. GaAs solar cell without Anti-Reflective Coating (ARC) layer was studied and shows the efficiency ranges between 8% to 15%, followed by GaAs solar cell with efficiency ranges between 20% to 25% with ARC layer. The substrate thickness for both GaAs solar cell was varied from 0. 1μm to 1. 0μm. Increased of P-type substrate thickness shows a small variation in efficiency with parabolic shape, while increased of N-type substrate thicknesss increased the efficiency between 21% to 25% for single layer GaAs with ARC thickness. Besides that, increased of P-type doping concentration from 1×1018cm-3 to 1×1019cm-3 and fixed N-type doping will decreased the efficiency. However increased the N-type doping concentration from 1×1017cm-3 to 1×1018cm-3 and fixed the P-type doping will increased the efficiency. The thickness of ARC layer on GaAs solar cell was studied and shows that highest efficiency achieved at narrow thickness of ARC.
LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death

LIMD1 (LIM domain-containing protein 1) is considered as a tumor suppressor, being deregulated in many cancers to include hematological malignancies; however, very little is known about the underlying mechanisms of its deregulation and its roles in carcinogenesis. Epstein-Barr Virus (EBV) is associated with a panel of malignancies of lymphocytic and epithelial origin. Using high throughput expression profiling, we have previously identified LIMD1 as a common marker associated with the oncogenic transcription factor IRF4 in EBV-related lymphomas and other hematological malignancies. In this study, we have identified potential conserved IRF4- and NFκB-binding motifs in the LIMD1 gene promoter, and both are demonstrated functional by promoter-reporter assays. We further show that LIMD1 is partially upregulated by EBV latent membrane protein 1 (LMP1) via IRF4 and NFκB in EBV latency. As to its role in the setting of EBV latent infection, we show that LIMD1 interacts with TRAF6, a crucial mediator of LMP1 signal transduction. Importantly, LIMD1 depletion impairs LMP1 signaling and functions, potentiates ionomycin-induced DNA damage and apoptosis, and inhibits p62-mediated selective autophagy. Taken together, these results show that LIMD1 is upregulated in EBV latency and plays an oncogenic role rather than that of a tumor suppressor. Our findings have identified LIMD1 as a novel player in EBV latency and oncogenesis, and open a novel research avenue, in which LIMD1 and p62 play crucial roles in linking DNA damage response (DDR), apoptosis, and autophagy and their potential interplay during viral oncogenesis.
Area-Delay Efficient Flipping 2-d DWT Structure using PEB Booth Multiplier

In this paper, an area-delay efficient structure for twodimensional discrete wavelet transform (2-D DWT) is proposed. The proposed structure has a small cycle period, and offer high throughput compared to the existing structures due to its efficient arithmetic unit (AU). The flipping scheme and efficient probability estimated biased (PEB) Booth multiplier provide efficient area-delay product (ADP) and energy per image (EPI) DWT computation for output of the filter. Compared with existing flipping-based structure, the proposed AU based flipping structures, involve 4.5 times as little as ADP for block-sizes 16. The flipping scheme offer ADP efficient large block size structure due to efficient arithmetic computation unit .
The buckling of capillaries in solid tumours

We develop a model of the buckling (both planar and axial) of capillaries in cancer tumours, using nonlinear solid mechanics. The compressive stress in the tumour interstitium is modelled as a consequence of the rapid proliferation of the tumour cells, using a multiplicative decomposition of the deformation gradient. In turn, the tumour cell proliferation is determined by the oxygen concentration (which is governed by the diffusion equation) and the solid stress. We apply a linear stability analysis to determine the onset of mechanical instability, and the Liapunov–Schmidt reduction to determine the postbuckling behaviour. We find that planar modes usually go unstable before axial modes, so that our model can explain the buckling of capillaries, but not as easily their tortuosity. We also find that the inclusion of anisotropic growth in our model can substantially affect the onset of buckling. Anisotropic growth also results in a feedback effect that substantially affects the magnitude of the buckle.
Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A

CCG-1423 suppresses several pathological processes including cancer cell migration, tissue fibrosis, and the development of atherosclerotic lesions. These suppressions are caused by inhibition of myocardin-related transcription factor A (MRTF-A), which is a critical factor for epithelial–mesenchymal transition (EMT). CCG-1423 can therefore be a potent inhibitor for EMT. CCG-1423 and related compounds, CCG-100602 and CCG-203971 possess similar biological activities. Although these compounds are comprised of two stereoisomers, the differences in their biological activities remain to be assessed. To address this issue, we stereoselectively synthesized optically pure isomers of these compounds and validated their biological activities. The S-isomer of CCG-1423 rather than the R-isomer exhibited modestly but significantly higher inhibitory effects on the cellular events triggered by MRTF-A activation including serum response factor-mediated gene expression and cell migration of fibroblasts and B16F10 melanoma cells. Accordingly, the S-isomer of CCG-1423 more potently blocked the serum-induced nuclear import of MRTF-A than the R-isomer. No such difference was observed in cells treated with each of two stereoisomers of CCG-100602 or CCG-203971. We previously reported that the N-terminal basic domain (NB), which functions as a nuclear localization signal of MRTF-A, is a binding site for CCG-1423. Consistent with the biological activities of two stereoisomers of CCG-1423, docking simulation demonstrated that the S-isomer of CCG-1423 was more likely to bind to NB than the R-isomer. This is a first report demonstrating the stereospecific biological activities of CCG-1423.
Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways

Although the genetic contribution is under debate, biological studies in multiple mouse models have suggested that the Disrupted-in-Schizophrenia-1 (DISC1) protein may contribute to susceptibility to psychiatric disorders. In the present study, we took the advantages of the Drosophila model to dissect the molecular pathways that can be affected by DISC1 in the context of pathology-related phenotypes. We found that three pathways that include the homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1. Consistently, these three molecules were downregulated in the induced pluripotent stem cell-derived forebrain neurons from the subjects carrying a frameshift deletion in DISC1 C-terminus. Importantly, the three pathways were underscored in the pathophysiology of psychiatric disorders in bioinformatics analysis. Taken together, our findings are in line with the polygenic theory of psychiatric disorders.
Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases

ABSTRACT Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune response causing inflammation. Loss of barrier function secondary to upregulation of zonulin, the only known physiological modulator of intercellular tight junctions, leads to uncontrolled influx of dietary and microbial antigens. Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can play in the development and progression of chronic inflammatory disorders has increased interest of both basic scientists and clinicians on the potential role of zonulin in the pathogenesis of these diseases. This review focuses on the recent research implicating zonulin as a master regulator of intestinal permeability linked to the development of several chronic inflammatory disorders.
Computation and Monitoring of Exclusive Closest Pairs

Given two datasets A and B, their exclusive closest pairs (ECP) join is a one-to-one assignment of objects from the two datasets, such that (i) the closest pair (a,b) in A times B is in the result and (ii) the remaining pairs are determined by removing objects a,b from A,B respectively, and recursively searching for the next closest pair. A real application of exclusive closest pairs is the computation of (car, parking slot) assignments. This paper introduces the problem and proposes several solutions that solve it in main-memory, exploiting space partitioning. In addition, we define a dynamic version of the problem, where the objective is to continuously monitor the ECP join solution, in an environment where the joined datasets change positions and content. Finally, we study an extended form of the query, where objects in one of the two joined sets (e.g., parking slots) have a capacity constraint, allowing them to match with multiple objects from the other set (e.g., cars). We show how our techniques can be extended for this variant and compare them with a previous solution to this problem. Experimental results on a system prototype demonstrate the efficiency and applicability of the proposed algorithms.
Damage Tensors and Tensors of Continuity in Stress Analysis

Abstract Starting from a third order skew-symmetric tensor of continuity to represent area vectors (bivectors) of Cauchy's tetrahedron in a damaged state, a second order damage tensor is found which has the diagonal form with respect to the considered coordinate system. The second part of the paper is concerned with the stresses in a damaged continuum. Introducing a linear operator of rank four a net-stress tensor is formulated. This tensor can be decomposed into a symmetric part and into an antisymmetric one, where only the symmetric part is equal to the net-stress tensor introduced by Rabotnov [7]. In view of the formulation of constitutive equations the non-symmetric property of the actual net-stress tensor is a disadvantage. Therefore, a pseudo-net-stress tensor is introduced, which is symmetric.
The Peripheral Olfactory Repertoire of the Lightbrown Apple Moth, Epiphyas postvittana

The lightbrown apple moth, Epiphyas postvittana is an increasingly global pest of horticultural crops. Like other moths, E. postvittana relies on olfactory cues to locate mates and oviposition sites. To detect these cues, moths have evolved families of genes encoding elements of the peripheral olfactory reception system, including odor carriers, receptors and degrading enzymes. Here we undertake a transcriptomic approach to identify members of these families expressed in the adult antennae of E. postvittana, describing open reading frames encoding 34 odorant binding proteins, 13 chemosensory proteins, 70 odorant receptors, 19 ionotropic receptors, nine gustatory receptors, two sensory neuron membrane proteins, 27 carboxylesterases, 20 glutathione-S-transferases, 49 cytochrome p450s and 18 takeout proteins. For the odorant receptors, quantitative RT-PCR corroborated RNAseq count data on steady state transcript levels. Of the eight odorant receptors that group phylogenetically with pheromone receptors from other moths, two displayed significant male-biased expression patterns, one displayed significant female-biased expression pattern and five were expressed equally in the antennae of both sexes. In addition, we found two male-biased odorant receptors that did not group with previously described pheromone receptors. This suite of olfaction-related genes provides a substantial resource for the functional characterization of this signal transduction system and the development of odor-mediated control strategies for horticultural pests.
NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint

NKp44 and NKp30 splice variant profiles have been shown to promote diverse cellular functions. Moreover, microenvironment factors such as TGF-β, IL-15 and IL-18 are able to influence both NKp44 and NKp30 splice variant profiles, leading to cytokine-associated profiles. Placenta and cancerous tissues have many similarities; both are immunologically privileged sites and both share immune tolerance mechanisms to support tissue development. Therefore, we studied the profiles of NKp44 and NKp30 splice variants in these states by comparing (i) decidua from pregnancy disorder and healthy gestation and (ii) matched normal and cancer tissue. Decidua samples had high incidence of both NKp44 and NKp30. In cancerous state it was different; while NKp30 expression was evident in most cancerous and matched normal tissues, NKp44 incidence was lower and was mostly associated with the cancerous tissues. A NKp44-1dominant inhibitory profile predominated in healthy pregnancy gestation. Interestingly, the NKp44-2/3 activation profile becomes the leading profile in spontaneous abortions, whereas balanced NKp44 profiles were observed in preeclampsia. In contrast, a clear preference for the NKp30a/b profile was evident in the 1st trimester decidua, yet no significant differences were observed for NKp30 profiles between healthy gestation and spontaneous abortions/preeclampsia. Both cancerous and matched normal tissues manifested balanced NKp30c inhibitory and NKp30a/b activation profiles with a NKp44-1dominant profile. However, a shift in NKp30 profiles between matched normal and cancer tissue was observed in half of the cases. To summarize, NKp44 and NKp30 splice variants profiles are tissue/condition specific and demonstrate similarity between placenta and cancerous tissues.
New Concept in Cranioplasty Based on Biomaterials Performance in Various Clinical Cases

Today, there are four known types of grafts for cranioplasty: autogenic grafts (the same bone is reused such) such as bone from cranium, ribs, shinbones, shoulder blades, sternum or ilia, allogenic grafts (the graft originates from another human) such as cartilage, xenogenic grafts (grafts transplanted from animals ex: bovines, pigs, etc.) and alloplastic gra fts (graft consisting of inorganic material) such as celluloid, Polymethylmethacrylate-PMMA, polyetheretherketone-PEEK, hydroxyapatite, polyethylene, silicone, ceramic and other derivatives; metallic implants such as Aluminium, Gold, Silver, Lead, Platinum, Titanium, Tantalum and their alloys. In this paper, the authors perform a comprehensive review of how the techniques have evolved from classic metals to modern biopolymers and how the modern technology will impact the future of cranial reconstruction. Also, comparative aspects related to the use of modern biopolymers like PMMA and PEEK in cranioplasty will be revealed based on surgical experience and clinical cases. Modern technology enables neurosurgeons to understand the threedimensional anatomy of the skull and defect and allows them to be able to create implants perfectly tailored to the size and shape of the defect without neglecting the volumetry of the skull. The best materials of today appear to be PEEK due to their excellent mechanical properties other properties like non-immunogenicity, non-oncogenicity, sterility, biological tolerance and an acceptable price range.
Dietary and Lifestyle Factors Associated with Colorectal Cancer Risk and Interactions with Microbiota: Fiber, Red or Processed Meat and Alcoholic Drinks

Background: Diets and lifestyles have been strongly associated with colorectal cancer (CRC). In the past several decades, emerging evidence has suggested that the gut microbiota may have a role in the development of CRC. Its interaction with diets and lifestyles could affect the carcinogenesis of CRC. Summary: This review presents the most recent epidemiologic and experimental evidence of three factors that may convincingly have a role in CRC, including fiber, red or processed meat, and alcohol, focusing on potential mechanisms and their interactions with the gut microbiota. Key Message: High consumption of fiber, low consumption of red or processed red meat as well as minimizing alcohol intake have been associated with a lower risk of CRC. Many microbial metabolites formed from those three substances may mediate the microbial diversity and the composition and abundance of the gut microbiota, which eventually affects the balance between health and disease, including CRC. Practical Implications: Based on our synthetic review, clinicians may probably offer some recommendations and explanations to their patients who may want to modulate their diet and lifestyle to prevent CRC. As an easily modifiable environmental factor, it may be possible that applying dietary or lifestyle intervention could effectively protect against the development of CRC in the future.
Taking Static Analysis to the Next Level: Proving the Absence of Run-Time Errors and Data Races with Astrée

We present an extension of Astree to concurrent C software. Astree is a sound static analyzer for run-time errors previously limited to sequential C software. Our extension employs a scalable abstraction which covers all possible thread interleavings, and soundly reports all run-time errors and data races: when the analyzer does not report any alarm, the program is proven free from those classes of errors. We show how this extension is able to support a variety of operating systems (such as POSIX threads, ARINC 653, OSEK/AUTOSAR) and report on experimental results obtained on concurrent software from different domains, including large industrial software.
Incomplete Re‐Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β‐Cell Dedifferentiation

There is increasing evidence to suggest that type 2 diabetes mellitus (T2D), a pandemic metabolic disease, may be caused by β‐cell dedifferentiation (βCD). However, there is currently no universal definition of βCD, and the underlying mechanism is poorly understood. We hypothesise that a high‐glucose in vitro environment mimics hyperglycaemia in vivo and that β cells grown in this milieu over a long period will undergo dedifferentiation. In the present study, we report that the pancreatic β cell line mouse insulinoma 6 (MIN6) grown under a high‐glucose condition did not undergo massive cell death but exhibited a glucose‐stimulated insulin‐secreting profile similar to that of immature β cells. The expression of insulin and the glucose‐sensing molecule glucose transporter 2 (Glut2) in late passage MIN6 cells was significantly lower than the early passage at both the RNA and protein levels. Mechanistically, these cells also expressed significantly less of the ‘pancreatic and duodenal homebox1’ (Pdx1) β‐cell transcription factor. Finally, passaged MIN6 cells dedifferentiated to demonstrate some features of β‐cell precursors, as well as neuroendocrine markers, in addition to expressing both glucagon and insulin. Thus, we concluded that high‐glucose passaged MIN6 cells passaged MIN6 cells. provide a cellular model of β‐cell dedifferentiation that can help researchers develop a better understanding of this process. These findings provide new insights that may enhance knowledge of the pathophysiology of T2D and facilitate the establishment of a novel strategy by which this disease can be treated.
Hermitian precoding for distributed MIMO systems

In this paper, we consider a distributed MIMO communication network in which multiple transmitters cooperatively send common messages to a single receiver. In this scenario, it is usually costly to acquire full channel state information at the transmitters (CSIT), i.e., every transmitter perfectly knows the overall channel state information (CSI) of the network. Hence, we assume individual CSIT (I-CSIT), i.e., each transmitter only knows its own CSI. We propose a novel precoding technique, named Hermitian precoding, to enhance the system performance under the constraint of I-CSIT. We show that the proposed scheme can perform close to the system capacity with full CSIT. This reveals that the amount of CSI required at the transmitters can be significantly reduced without considerably compromising performance.