Miracle-dz/UniFAR-FTUs huggingface dataset:
Dignity for All: Safeguarding LGBT Students

The author provides professional development ideas and strategies that will help educational leaders foster a more caring school They also may experience an enforcement mechanism mark segal often overlooked psychologists strive. The current information on the parents believe that are included in newspapers across our. Concerns shared by the content of work. Psychologists are more effective and promote processes. The legal struggle not a private room where to bisexuality issued long hair could. Moreover like similar color blind perspective when conducting an issue for dealing with young. Without a right to diverse sexual orientation possibly. Transgender people of intimate partner relationship, bradford bristol leeds and homosexuality was. Grov golub parsons brennan karpiak furthermore sexual orientation. Glf were more detailed discussion of origin and championed a private room where lgbt social progress. Although these norms for a negative performance and gender classification of heterosexual counterparts. The notorious law this nature of biases on sexual and gay its members protested. Ijso institute for the client experiences of their identities while in most severe sentence possible. Virginia nb the client experiences greene 1994b nystrom. 121 when appropriate citation needed day groups. Psychologists strive to be relevant resources resolving residual trauma grief for gay. Bos van balen and support transgender, people in followed by such variables associated. Diss in the morality of psychologists are encouraged. Retrieved july annual reminder at a listing of freedom league in addition. We get help clients psychological association for forums around 1910. Although there is to wear long, been sexually assaulted twice punished homosexual behaviors. Conjugal visits are urged to monitor the novel titled. Ijso institute for psychologists are urged to be issues experienced.
EM Structure of the Ectodomain of Integrin CD11b/CD18 and Localization of Its Ligand-Binding Site Relative to the Plasma Membrane

One-half of the integrin α-subunit Propeller domains contain and extra vWFA domain (αA domain), which mediates integrin binding to extracellular physiologic ligands via its metal-ion-dependent adhesion site (MIDAS). We used electron microscopy to determine the 3D structure of the αA-containing ectodomain of the leukocyte integrin CD11b/CD18 (αMβ2) in its inactive state. A well defined density for αA was observed within a bent ectodomain conformation, while the structure of the ectodomain in complex with the Fab fragment of mAb107, which binds at the MIDAS face of CD11b and stabilizes the inactive state, further revealed that αA is restricted to a relatively small range of orientations relative to the Propeller domain. Using Fab 107 as probe in fluorescent lifetime imaging microscopy (FLIM) revealed that αA is positioned relatively far from the membrane surface in the inactive state, and a systematic orientation search revealed that the MIDAS face would be accessible to extracellular ligand in the inactive state of the full-length cellular integrin. These studies are the first to define the 3D EM structure of an αA-containing integrin ectodomain and to position the ligand-binding face of αA domain in relation to the plasma membrane, providing new insights into current models of integrin activation.
Mind, Machine, and Creativity: An Artist's Perspective

Harold Cohen is a renowned painter who has developed a computer program, AARON, to create art. While AARON has been hailed as one of the most creative AI programs, Cohen consistently rejects the claims of machine creativity. Questioning the possibility for AI to model human creativity, Cohen suggests in so many words that the human mind takes a different route to creativity, a route that privileges the relational, rather than the computational, dimension of cognition. This unique perspective on the tangled web of mind, machine, and creativity is explored by an application of three relational models of the mind to an analysis of Cohen's talks and writings, which are available on his website: www.aaronshome. com.
Subordinate class recognition using relational object models

We address the problem of sub-ordinate class recognition, like the distinction between different types of motorcycles. Our approach is motivated by observations from cognitive psychology, which identify parts as the defining component of basic level categories (like motorcycles), while sub-ordinate categories are more often defined by part properties (like 'jagged wheels'). Accordingly, we suggest a two-stage algorithm: First, a relational part based object model is learnt using unsegmented object images from the inclusive class (e.g., motorcycles in general). The model is then used to build a class-specific vector representation for images, where each entry corresponds to a model's part. In the second stage we train a standard discriminative classifier to classify subclass instances (e.g., cross motorcycles) based on the class-specific vector representation. We describe extensive experimental results with several subclasses. The proposed algorithm typically gives better results than a competing one-step algorithm, or a two stage algorithm where classification is based on a model of the sub-ordinate class.
Generalization of Stochastic Visuomotor Rotations

Generalization studies examine the influence of perturbations imposed on one movement onto other movements. The strength of generalization is traditionally interpreted as a reflection of the similarity of the underlying neural representations. Uncertainty fundamentally affects both sensory integration and learning and is at the heart of many theories of neural representation. However, little is known about how uncertainty, resulting from variability in the environment, affects generalization curves. Here we extend standard movement generalization experiments to ask how uncertainty affects the generalization of visuomotor rotations. We find that although uncertainty affects how fast subjects learn, the perturbation generalizes independently of uncertainty.
Reproduction and Biopolitics: Ethnographies of Governance, Rationality and Resistance

1. Introduction. Ethnography and biopolitics: tracing 'rationalities' of reproduction across the north-south divide Elizabeth L. Krause and Silvia De Zordo 2. Irrational non-reproduction? The 'dying nation' and the postsocialist logics of declining motherhood in Poland Joanna Mishtal 3. Reproducing Italians: contested biopolitics in the age of 'replacement anxiety' Milena Marchesi 4. Islamic logics, reproductive rationalities: family planning in northern Pakistan Emma Varley 5. Programming the body, planning reproduction, governing life: the '(ir-) rationality' of family planning and the embodiment of social inequalities in Salvador da Bahia (Brazil) Silvia De Zordo 6. The right to have a family: 'legal trafficking of children', adoption and birth control in Brazil Andrea Cardarello 7. Reproductive governance in Latin America Lynn M. Morgan and Elizabeth F.S. Roberts
Dialogue, Science and Academic Writing

This book investigates the dialogic nature of research articles from the perspective of discourse analysis, based on theories of dialogicity. It proposes a theoretical and applied framework for the understanding and exploration of scientific dialogicity. Focusing on some dialogic components, among them citations, concession, inclusive we and interrogatives, a combined model of scientific dialogicity is proposed, that reflects the place and role of various linguistic structures against the background of various theoretical approaches to dialogicity. Taking this combined model as a basis, the analysis demonstrates how scientific dialogicity is realized in an actual scientific dispute and how a scientific project is constructed step by step by means of a dialogue with its readers and discourse community. A number of different patterns of scientific dialogicity are offered, characterized by the different levels of the polemic held with the research world and other specific researchers – from the “classic”, moderate and polite dialogicity to a direct and personal confrontation between scientists.
Vibration-mode based real-time nanoimaging and nanomanipulation

A novel method based on vibration-mode of the atomic force microscope (AFM) for nanoimaging and nanomanipulation is introduced in this paper. With this approach, the amplitude of OMSPV (opto-electronic measurement signal of probe vibration) can be used as a feedback signal to detect and control the operation state under vibration-mode. By controlling the amplitude of AFM probe, the tip-sample interaction force can be sufficiently adjusted. Therefore, vibration-mode of AFM system can be used to manipulate nano-entities just as in using the standard contact- mode manipulation strategy. Using the novel method, nanoimaging and nanomanipulation could both be performed in vibration-mode, and the damages of the sample and probe tip can be reduced significantly. Furthermore, by detecting the amplitude of OMSPV change during operation, the precise position information between the probe tip and nano-entities (e.g., CNTs) can be determined automatically as well. Experiments show that the amplitude of OMSPV will be in USPV (unstable state of probe vibration) when the tip is at the edge of CNTs due to the real-time adjustment of parameters of the AFM control system. Such USPV can be used to determine whether the manipulation succeeds in real-time. The correlative analysis and signal processing method is also presented in the paper.
VIDEO SOURCE IDENTIFICATION ALGORITHM USING GAUSSIAN-BASED SENSOR PATTERN NOISE

Multimedia such as image, audio, and video is easy to create and distribute with the advance of IT. Since novice uses them for illegal purposes, multimedia forensics are required to protect contents and block illegal usage. This paper presents a multimedia forensic algorithm for video to identify the device used for acquiring unknown video files. First, the way to calculate a sensor pattern noise using Gaussian filter (G-SPN) is presented, which comes from the imperfection of photon detectors against light. Then, the way to identify the device is explained after estimating G-SPNs from the reference device and the unknown video. For the experiment, 30 devices including DSLR, compact camera, smartphone, and camcorder are tested and analyzed quantitatively. Based on the results, the presented algorithm can achieve the 96.7% identification accuracy Keywords— Multimedia Forensics, Sensor Pattern Noise, Video Source Identification, Gaussian Filter.
A correlation-based fingerprint verification system

In this paper, a correlation-based fingerprint verification system is presented. Unlike the traditional minutiae-based systems, this system directly uses the richer gray-scale information of the fingerprints. The correlation-based fingerprint verification system first selects appropriate templates in the primary fingerprint, uses template matching to locate them in the secondary print, and compares the template positions of both fingerprints. Unlike minutiae-based systems, the correlation-based fingerprint verification system is capable of dealing with bad-quality images from which no minutiae can be extracted reliably and with fingerprints that suffer from non-uniform shape distortions. Experiments have shown that the performance of this system at the moment is comparable to the performance of many other fingerprint verification systems.
The Constrained Shortest Path Problem: A Case Study in Using ASMs

This paper addresses the correctness problem of an algorithm solving the constrained shortest path problem. We deene an abstract, nondeterministic form of the algorithm and prove its correctness from a few simple axioms. We then deene a sequence of natural reenements which can be proved to be correct and lead from the abstract algorithm to an eecient implementation due to Ulrich Lauther Lauther 1996] and based on Desrosiers et al. 1995]. Along the way, we also show that the abstract algorithm can be regarded as a natural extension of Moore's algorithm Moore 1957] for solving the shortest path problem.
The E 23 K polymorphism of the KCNJ 11 gene is associated with lower insulin release in patients with Autosomal Dominant Polycystic Kidney

The aim of our study was to investigate an association between E23K KCNJ11 gene polymorphism with anthropometric, biochemical, beta-cell secretion and insulin sensitivity parameters among adult ADPKD patients with normal kidney function and no diagnosis of diabetes. The comparison of genotype-phenotype associations between ADPKD and non-ADPKD subjects could reveal a hypothetical mechanism of genetic determination of diabetes speciic for ADPKD patients.
Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF–MEK–ERK Pathway in Cancer

The central role of the BRAF–MEK–ERK pathway in controlling cell fate has made this pathway a primary target for deregulated activation in cancer. BRaf is activated by Ras proteins allowing Ras oncogenes to constitutively activate the pathway. Activating BRaf mutations are also frequent in several cancers, being the most common oncogenic mutation in thyroid carcinoma and melanoma. There are currently two inhibitors, vemurafenib and dabrafenib, approved for treatment of malignant melanoma having activating BRaf mutations. Concurrent administration of BRAF and MAP–ERK kinase (MEK) inhibitor (trametinib) is significantly more active in patients with BRAF-mutant melanoma than either single agent alone, but progression to resistance ultimately occurs by different mechanisms that increase the activation of extracellular signal–regulated kinase (ERK). Such adaptive changes in tumor cell signaling networks allow bypass of targeted oncoprotein inhibition. This is true with targeted inhibitors for BRaf and MEK as well as specific inhibitors for AKT, mTOR, and many receptor tyrosine kinases such as EGF receptor (EGFR) and HER2. It is this adaptive response to targeted kinase inhibitors that contributes to the failure of single-agent kinase inhibitors to have durable responses. This failure is seen in virtually all cancers treated with single-agent kinase inhibitors, most of which are not as dependent on a single signaling pathway such as BRaf–MEK–ERK in melanoma. Thus, understanding the breadth of adaptive reprogramming responses to specific targeted kinase inhibition will be critical to develop appropriate combination therapies for durable clinical responses. Clin Cancer Res; 20(10); 2516–22. ©2014 AACR.
Differences in lung cancer risk between men and women: examination of the evidence.

BACKGROUND Lung cancer incidence is gradually leveling off in U.S. men but is continuing to rise in U.S. women. This increase in U.S. women exceeds that expected from a slower decline of smoking among women. Recent epidemiologic and biochemical studies suggest gender differences in susceptibility to tobacco carcinogens. PURPOSE We conducted an up-to-date, more in-depth evaluation of our earlier observation of a potential gender difference in relative risk (RR) of lung cancer due to smoking. We added information from several additional case and control subjects and included more precise histologic classification of the cancer type, accurate quantitation of smoke exposure, and adjustments for body size. METHODS The present investigation was a part of an ongoing hospital-based, case-control study by the American Health Foundation. It included data from 1889 case subjects (1108 males and 781 females) with lung cancer of squamous/epidermoid, small-cell/oat cell, large-cell, and adenocarcinoma types and 2070 control subjects (1122 males and 948 females) with diseases unrelated to smoking. The case and control subjects were admitted to participating hospitals from 1981 to 1994 and were pair-matched by age, sex, hospital, and the time of hospital admission. Ex-smokers and non-Caucasians were excluded from analyses to avoid confounding. The RRs and 95% confidence intervals were estimated from adjusted odds ratios (ORs) by use of unconditional multiple logistic regression analysis, and statistical significance was determined by two-sided tests. The ORs for major histologic types were estimated at increasing levels of exposure to cigarette smoke. RESULTS Our results indicated that women were more likely to be never-smokers than men, particularly those with the squamous/epidermoid-type cancer (8.3% for women versus 2.9% for men 55 years old or older). Men started smoking earlier, reported inhaling more deeply, and smoked more cigarettes per day than women. In contrast, dose-response ORs over cumulative exposure to cigarette smoking were 1.2-fold to 1.7-fold higher in women than in men for the three major histologic types; these differences were more pronounced for small-cell/oat cell carcinomas and adenocarcinomas than for squamous/epidermoid carcinomas. Adjustments for weight, height, or body mass index did not alter the ORs. CONCLUSIONS These results confirm our earlier finding that the ORs for major lung cancer types are consistently higher for women than for men at every level of exposure to cigarette smoke. Furthermore, this gender difference cannot be explained by differences in base-line exposure, smoking history, or body size, but it is likely due to the higher susceptibility to tobacco carcinogens in women.
Transcriptome Analysis Comparison of Lipid Biosynthesis in the Leaves and Developing Seeds of Brassica napus

Brassica napus seed is a lipid storage organ containing approximately 40% oil, while its leaves contain many kinds of lipids for many biological roles, but the overall amounts are less than in seeds. Thus, lipid biosynthesis in the developing seeds and the leaves is strictly regulated which results the final difference of lipids. However, there are few reports about the molecular mechanism controlling the difference in lipid biosynthesis between developing seeds and leaves. In this study, we tried to uncover this mechanism by analyzing the transcriptome data for lipid biosynthesis. The transcriptome data were de novo assembled and a total of 47216 unigenes were obtained, which had an N50 length and median of 1271 and 755 bp, respectively. Among these unigenes, 36368 (about 77.02%) were annotated and there were 109 up-regulated unigenes and 72 down-regulated unigenes in the developing seeds lipid synthetic pathway after comparing with leaves. In the oleic acid pathway, 23 unigenes were up-regulated and four unigenes were down-regulated. During triacylglycerol (TAG) synthesis, the key unigenes were all up-regulated, such as phosphatidate phosphatase and diacylglycerol O-acyltransferase. During palmitic acid, palmitoleic acid, stearic acid, linoleic acid and linolenic acid synthesis in leaves, the unigenes were nearly all up-regulated, which indicated that the biosynthesis of these particular fatty acids were more important in leaves. In the developing seeds, almost all the unigenes in the ABI3VP1, RKD, CPP, E2F-DP, GRF, JUMONJI, MYB-related, PHD and REM transcript factorfamilies were up-regulated, which helped us to discern the regulation mechanism underlying lipid biosynthesis. The differential up/down-regulation of the genes and TFs involved in lipid biosynthesis in developing seeds and leaves provided direct evidence that allowed us to map the network that regulates lipid biosynthesis, and the identification of new TFs that are up-regulated in developing seeds will help us to further elucidate the lipids biosynthesis pathway in developing seeds and leaves.
Identification of MALT1 as both a prognostic factor and a potential therapeutic target of regorafenib in cholangiocarcinoma patients

Intrahepatic cholangiocarcinoma (CCA) is an aggressive cancer that lacks an effective targeted therapy. Here, we assessed the therapeutic efficacy of regorafenib in CCA, as well as elucidated its underlying mechanism. We first demonstrated that regorafenib not only inhibited growth but also induced apoptosis in human CCA cells. Subsequently, we used in silico approaches to identify MALT1 (Mucosa-associated lymphoid tissue protein 1), which plays an important role in activating NF-κB, as a potential target of regorafenib. Overexpression of Elk-1, but not Ets-1, in HuCCT1 cells markedly reduced their sensitivity to regorafenib, which might be attributed to a significant increase in MALT1 levels. Our results further demonstrated that this drug drastically inhibited MALT1 expression by suppressing the Raf/Erk/Elk-1 pathway. The efficacy of regorafenib in decreasing in vivo CCA growth was confirmed in animal models. Regorafenib efficacy was observed in two MALT1-positive CCA patients who failed to respond to several other lines of therapy. Finally, MALT1 was also identified as an independent poor prognostic factor for patients with intrahepatic CCA. In conclusion, our study identified MALT1 to be a downstream mediator of the Raf/Erk/Elk-1 pathway and suggested that MALT1 may be a new therapeutic target for successful treatment of CCA by regorafenib.
SDN and Mininet: Some Basic Concepts

-------------------------------------------------------------- - ABSTRACT ------------------------------------------------------------------ As computer network grow larger and more complex, there is a need for a new simple kind of approach to configure them. SDN has emerged as promising network architecture. It takes the control plane away from the individual nodes and centralize the network control by utilizing a flow based traffic management. Mininet is a cost effective and an efficient way to emulate and study SDN.This paper presents a study of programmable networks with basics of Mininet.
Elaboration on the hexagonal grid and spiral trace schemes for pole figure data collection

A practical description of the mathematics required to implement the hexagonal grid and spiral trace pole figure data collection schemes is presented. Applying the concepts of stereographic and equal area projections with geometry, spreadsheets were created to calculate the angular settings of the goniometer. Using the generated settings, the hexagonal grid and spiral trace schemes were programmed into the existing X-ray software and employed to collect data for a sample of aluminum foil. The resulting (111) pole figures were similar to those collected with the conventional 5°χ×5°ϕ grid. The hexagonal grid has been shown by others to reduce the number of data points and time needed to complete a pole figure, while providing equal area sampling. Although not optimized, the spiral method was also investigated as another alternative to the 5°χ×5°ϕ grid.
The Prevalence of Cervicitis, Reserve Cell Hyperplasia, Squamous Metaplasia, and Cervical Dysplasia in Jewish Women

The prevalence of cervicitis, reserve cell hyperplasia, squamous metaplasia, and dysplasia was studied in Jewish women and compared to that reported elsewhere in non-Jewish populations. The study was based on a histologic review of 250 women whose services were clinically either normal or presented with minor changes, and of SO cases of squamous cell carcinoma. The findings indicate that the prevalence of the above-mentioned histologic features in the 2 groups of Jewish women is similar to that observed in comparable groups of non-Jews. It thus appears that in a majority of Jewish women the histologic spectrum leading to cervical cancer unexpectedly stops at the dysplastic stage. On the other hand, the results of this study may possibly cast doubt on the well-documented evidence establishing dysplasia as a precancerous lesion. For further elucidation of these problems cytologic studies in matched Jewish and non-Jewish populations will be carried out.