Miracle-dz/UniFAR-FTUs huggingface dataset:
DISORDER IN A CHILD OF THREE

The development of multiple personality disorder (MPD) in a three year old girl is described. She had been followed since the age of 14 months. The subject of a custody dispute, she suffered from multiple on-going traumas, which caused a dissociative state to develop. The traumata were separation from the primary love object, physical and sexual abuse, and deliberate attempts l7y her genetic family of origin to erase her recall of her early history. The development of her MPD is documented on videotapes that begin before an alter personality is fully developed and continue to the time when the alter personality is clearly separate. Finally, they show the treatment phase during which integration occurred. This is probably the earliest documented case of MPD and it gives credence to patients' retrospective reports of the use of this adaptive strategy at such an early age. This case may also indicate that more attention needs to be paid to the impact of ongoing traumas and the development of acute disorders as a means of minimizing post-traumatic damage.
Random graphic user password authentication scheme in mobile devices

Smart mobile terminal are an essential device in our life today. The user usually enters in the related words or draws a simple graphic on the touch screen as passwords for unlocking the screensaver. Although this way can provide users with simple and convenient security mechanism, the process would increase the risk of words or graphic information leakage under the strict security consideration. Usually for this type of keypad lock screen app you can only customize the simple pattern or swipe-to-unlock screen with a static image on a background image that you select to unlock your phone. Therefore, the interested parties could have a chance to eavesdrop the simple graphic pattern information in order to hacking the smart device for stealing the personal information. Due to lack of the proper identity authentication mechanism in the usually keypad lock screen app, this paper proposes a new graphic pattern protection mechanism for enhance authentication level in the keypad lock screen app field. By randomly changing the fixed position of the digital graphics that shows on the touch screen, the user can draw different graphic pattern every time based on the unique or backup PIN password to unlock the screen. Not only added the random graphic pattern authentication method indeed increase the personal secret information being stolen difficulty and complexity, it provides more security level than the traditional graphic pattern authentication in keypad lock screen as well.
Abuse and neglect of elderly persons.

The metaphor of domestic violence as chronic disease is a useful one for clinicians. Studies of domestic violence over the life span suggest that, like many ongoing illnesses that are typified by periods of quiescence and exacerbation, abuse is more often episodic and recurrent than an isolated event.1–3 This metaphor may also help to remind physicians that elderly patients are at risk; a report from the House Select Committee on Aging has suggested that between 1 million and 2 million older Americans experience mistreatment each year.4 Given the scope of this clinical and public health problem, what has been .
The γ/σ1 and α/σ2 Hemicomplexes of Clathrin Adaptors AP-1 and AP-2 Harbor the Dileucine Recognition Site

The clathrin adaptors AP-1 and AP-2 bind cargo proteins via two types of motifs: tyrosine-based Yxx and dileucinebased [DE]XXXL[LI]. Although it is well established that Yxx motifs bind to the subunits of AP-1 or AP-2, dileucine motifs have been reported to bind to either the or subunits of these adaptors as well as the /1 hemicomplex of AP-1. To clarify this controversy, the various subunits of AP-1 and AP-2 were expressed individually and in hemicomplex form in insect cells, and they were used in glutathione S-transferase pull-down assays to determine their binding properties. We report that the / 1o r/2 hemicomplexes bound the dileucine-based motifs of several proteins quite strongly, whereas binding by the 1/1 and 2/2 hemicomplexes, and the individual or subunits, was extremely weak or undetectable. The /1 and /2 hemicomplexes displayed substantial differences in their preference for particular dileucine-based motifs. Most strikingly, an aspartate at position 4 compromised binding to the /1 hemicomplex, whereas minimally affecting binding to /2. There was an excellent correlation between binding to the /2 hemicomplex and in vivo internalization mediated by the dileucine-based sorting signals. These findings provide new insights into the trafficking mechanisms of D/EXXXL[LI]-mediated sorting signals.
Oxcarbazepine in the Treatment of Bipolar Disorder: A Review

Objective: To review the data on the efficacy of oxcarbazepine (OXC) in bipolar disorder (BD) and to provide recommendations for clinicians on the use of this medication in treating BD. Method: Using the terms oxcarbazepine and bipolar disorder, oxcarbazepine and mania, or oxcarbazepine and bipolar depression, we conducted a computer-aided search of MEDLINE for the years 1950 to 2005. Results: Case reports, retrospective chart reviews, open prospective studies, and double-blind studies reported the efficacy and effectiveness of OXC in treating BD. The data indicate that OXC has efficacy in treating acute mania and may be a useful add-on in treating acute bipolar depression and in BD prophylaxis. OXC is generally well-tolerated. Conclusion: We recommend using OXC as monotherapy or as add-on therapy in refractory mania, but we recommend it be used predominantly as an add-on treatment for other phases of BD in patients who have not improved with well-established treatments or in patients who have difficulty tolerating adequate dosages. Objectifs: Examiner les données sur l'efficacité de l'oxcarbazépine (OXC) dans le trouble bipolaire (TB) et fournir des recommandations aux cliniciens sur l'utilisation de ce médicament pour traiter le TB. Méthode: Nous avons mené une recherche informatique dans MEDLINE recouvrant les années 1950 à 2005, à l'aide des termes oxcarbazépine et trouble bipolaire, oxcarbazépine et manie, ou oxcarbazépine et dépression bipolaire. Résultats: Des études de cas, des études de dossiers rétrospectives, des études prospectives ouvertes et des études à double insu portaient sur l'efficacité et l'utilité de l'OXC dans le traitement du TB. Les données indiquent que l'OXC est efficace pour traiter la manie aiguë et peut être un ajout utile pour traiter la dépression bipolaire aiguë et pour la prophylaxie du TB. L'OXC est généralement bien tolérée. Conclusion: Nous recommandons l'utilisation de l'OXC comme monothérapie ou comme ajout à la thérapie de la manie réfractaire, mais nous recommandons de l'utiliser principalement comme ajout au traitement d'autres phases du TB, chez des patients qui ne se sont pas améliorés avec les traitements bien établis ou chez les patients qui ont de la difficulté à tolérer les doses adéquates.
The Effect of Two Post-Space Preparation Techniques on the Seal of Resilon and Gutta-Percha Obturation Materials

INTRODUCTION The aim of this study was to compare the effect of post space preparation with Gates Glidden drills or hand files on the sealing ability of gutta-percha or Resilon obturation materials. MATERIALS AND METHODS One-hundred and four single-rooted human teeth were instrumented and divided into four experimental groups (n=21 each) and two groups of positive and negative control (n=10). Forty-two roots of experimental groups were obturated with gutta-percha and Dorifill sealer; and 42 roots with Resilon/Epiphany self-etch using lateral compaction technique. Each gutta-percha or Resilon group was divided into two subgroups (n=21) and post-space prepared with either Gates Glidden drills or hand files and chloroform. After post space preparation, 5 mm of apical gutta-percha or Resilon was left intact. The whole system was sterilized with gamma-rays. Saliva leakage was tested using a split-chamber model. Specimens were monitored every 24 hours for 30 days. The data were analyzed using log-rank test and Cox regression analysis. RESULTS There were no significant differences between the sealing ability of gutta-percha and Resilon. Furthermore, no significant difference was found between two different methods of post space preparation (P>0.05). CONCLUSION Under the limitations of this ex vivo study, there were no significant differences between the sealing ability of Resilon and gutta-percha after post space preparation using Gates Glidden drills or hand files with the aid of chloroform.
A New Data Storage and Service Model of China Web InfoMall 1

The Web consists of enormous pages which is easier vanishing than traditional media such as newspaper, journals. To preserve the web resources, we began the China Web archiving project, named Web InfoMall, from 2001. The paper describes the data storage and service model of Web InfoMall 2.0 to meet the goals of collecting the stuff broadly, storing them perennially, and locating requests efficiently. Currently the Web InfoMall holds 0.7 billion pages (10.6 terabyte) together with 5 terabyte of digital web resources other than web pages, having the ability of collecting more than 1 million pages per day, a storage capacity to hold more than 10 billion pages (about 150 terabyte), and a scheme to manage large numbers of pages.
Nitric oxide synthase in hypoxic or ischemic brain injury

Abstract Hypoxic or ischemic stress causes many serious brain injuries, including stroke and neonatal hypoxia ischemia encephalopathy. During brain hypoxia ischemia processes, nitric oxide (NO) may play either a neurotoxic or a neuroprotective role, depending upon factors such as the NO synthase (NOS) isoform, the cell type by which NO is produced, and the temporal stage after the onset of the hypoxic ischemic brain injury. Excessive NO production can be neurotoxic, leading to cascade reactions of excitotoxicity, inflammation, apoptosis, and deteriorating primary brain injury. In contrast, NO produced by endothelial NOS plays a neuroprotective role by maintaining cerebral blood flow and preventing neuronal injury, as well as inhibiting platelet and leukocyte adhesion. Sometimes, NO-derived inducible NOS and neuronal NOS in special areas may also play neuroprotective roles. Therefore, this review summarizes the different roles and the regulation of the three NOS isoforms in hypoxic or ischemic brain injury as revealed in research in recent years, focusing on the neurotoxic role of the three NOS isoforms involved in mechanisms of hypoxic or ischemic brain injury.
Enhanced bone healing around nanohydroxyapatite-coated polyetheretherketone implants: An experimental study in rabbit bone

Objective To investigate the bone response to threaded polyetheretherketone (PEEK) implants coated with nanohydroxyapatite. Materials and methods A total of 39 PEEK implants were coated with nanocrystalline hydroxyapatite and 39 uncoated implants were used as controls. The implant surface was characterized by optical interferometry and scanning electron microscope. The implants were inserted in the tibia and femur of 13 rabbits. After 6 weeks of healing, quantitative and qualitative analyses were performed. Results The test implants showed significantly higher removal torque test values compared with the control group. Histomorphometric evaluation demonstrated higher bone-to-implant contact for the test implants; however, there were no differences in bone area between the groups. Qualitative histological analyses demonstrated inflammatory cellular reactions in close vicinity of both implant surfaces. A two-cell layer of foreign body giant cells was observed irrespective of sample type. Conclusion Our findings demonstrate that implants with a threaded design render good stability to PEEK in both coated and uncoated implants. Nanohydroxyapatite-coated PEEK implants demonstrated improved bone formation compared with uncoated controls.
Drawing Circles in the Sand: Integrating Content into Serious Games

One of the most important differentiators between Commercial Games and Serious Games is content; delivered in a way that is successfully integrated with engaging game play and achieves the desired learning outcomes by delivering skills and knowledge effectively to the end-user. This ability to integrate content effectively is the key to producing “killer” Serious Games that deliver demonstrable learning outcomes, business benefits and overall value. However, achieving this nirvana is not a trivial task. Utilising lessons learned and case studies, this chapter provides an overview of why this process can be so challenging, including the differing experiences from the perspective of three stakeholders (game designer, instructional designer/learning psychologist and subject matter expert), how to manage preconceptions and balance their priorities. The case studies will also show how different methodologies, techniques and technology have been applied to help solve this fundamental challenge of delivering a successful serious game. Advice is provided on how to facilitate this process, capture the correct requirements and create a design that meets and exceeds the expectations of all the stakeholders involved, including the client/customer and the end user.
Mixed abstractions for floating-point arithmetic

Floating-point arithmetic is essential for many embedded and safety-critical systems, such as in the avionics industry. Inaccuracies in floating-point calculations can cause subtle changes of the control flow, potentially leading to disastrous errors. In this paper, we present a simple and general, yet powerful framework for building abstractions from formulas, and instantiate this framework to a bit-accurate, sound and complete decision procedure for IEEE-compliant binary floatingpoint arithmetic. Our procedure benefits in practice from its ability to flexibly harness both over- and underapproximations in the abstraction process. We demonstrate the potency of the procedure for the formal analysis of floating-point software.
CLC channel function and dysfunction in health and disease

CLC channels and transporters are expressed in most tissues and fulfill diverse functions. There are four human CLC channels, ClC-1, ClC-2, ClC-Ka, and ClC-Kb, and five CLC transporters, ClC-3 through −7. Some of the CLC channels additionally associate with accessory subunits. Whereas barttin is mandatory for the functional expression of ClC-K, GlialCam is a facultative subunit of ClC-2 which modifies gating and thus increases the functional variability within the CLC family. Isoform-specific ion conduction and gating properties optimize distinct CLC channels for their cellular tasks. ClC-1 preferentially conducts at negative voltages, and the resulting inward rectification provides a large resting chloride conductance without interference with the muscle action potential. Exclusive opening at voltages negative to the chloride reversal potential allows for ClC-2 to regulate intracellular chloride concentrations. ClC-Ka and ClC-Kb are equally suited for inward and outward currents to support transcellular chloride fluxes. Every human CLC channel gene has been linked to a genetic disease, and studying these mutations has provided much information about the physiological roles and the molecular basis of CLC channel function. Mutations in the gene encoding ClC-1 cause myotonia congenita, a disease characterized by sarcolemmal hyperexcitability and muscle stiffness. Loss-of-function of ClC-Kb/barttin channels impairs NaCl resorption in the limb of Henle and causes hyponatriaemia, hypovolemia and hypotension in patients suffering from Bartter syndrome. Mutations in CLCN2 were found in patients with CNS disorders but the functional role of this isoform is still not understood. Recent links between ClC-1 and epilepsy and ClC-Ka and heart failure suggested novel cellular functions of these proteins. This review aims to survey the knowledge about physiological and pathophysiological functions of human CLC channels in the light of recent discoveries from biophysical, physiological, and genetic studies.
Accounting history and religion: A review of studies and a research agenda

Since around 2003, the number and extent of studies into accounting history and religion has increased significantly from their prior scarcity. This growing interest in the junction of accounting, religion and theology recognizes the social and economic importance of belief systems and religious institutions. Yet, publications are unevenly distributed, with a focus on a micro-perspective – analysing the manner in which accounting is practised within organizations. Few studies take a macro-perspective to consider how religion influenced (or potentially could influence) accounting outside of religious institutions. The purpose of this article is to review the contributions in the last three decades, to highlight the topics that remain relatively unexplored, and thus to encourage more research into accounting history and religion. Opportunities for extending knowledge include: comparative studies, studies of countries, people and faiths that have been left largely unexplored, and studies from theologians concerning key concepts (such as ethics) which impact academic understandings, as well as the practical application, of accounting.
Glucose and glycerol concentrations and their tracer enrichment measurements using liquid chromatography tandem mass spectrometry.

The present study describes a new liquid chromatography tandem mass spectrometry method for high-throughput quantification of glucose and glycerol in human plasma using stable isotopically labeled internal standards and is suitable for simultaneous measurements of glucose and glycerol enrichments in connection to in vivo metabolic studies investigating glucose turnover and lipolytic rate. Moreover, in order to keep up with this new fast analysis, simple derivatization procedures have been developed. Prior to analysis, glucose and glycerol were derivatized using benzoyl chloride in order to form benzoylated derivatives via new simplified fast procedures. For glucose, two internal standards were evaluated, [U-(13) C(6)]glucose and [U-(13) C(6), D(7)]glucose, and for glycerol, [U-(13) C(3), D(8)]glycerol was used. The method was validated by means of calibration curves, quality control samples, and plasma samples spiked with [6,6-D(2)]glucose, [U-(13) C(6)]glucose, and [1,1,2,3,3-D(5)]glycerol in order to test accuracy, precision, and recovery of the method. Moreover, post preparative and freeze-thaw sample stability were tested. The correlation of calibration curves for the glucose concentration were r(2) = 0.9998 for [U-(13) C(6)]glucose and r(2) = 0.9996 for [U-(13) C(6), D(7)]glucose, and r(2) = 0.9995 for the glycerol concentration. Interday accuracy for glucose using [U-(13) C(6)]glucose and glycerol determined in spiked plasma were respectively 103.5% and 106.0%, and the coefficients of variation were 2.0% and 9.7%, respectively. After derivatization, plasma samples were stable for at least 14 days. In conclusion, we have developed and validated a novel, accurate, and sensitive high-throughput liquid chromatography tandem mass spectrometry method for simultaneous determination of glucose and glycerol concentrations and enrichment of infused tracers most commonly used in human metabolic kinetic studies.
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability

Cell cycle regulation and DNA repair following damage are essential for maintaining genome integrity. DNA damage activates checkpoints in order to repair damaged DNA prior to exit to the next phase of cell cycle. Recently, we have shown the role of Ada3, a component of various histone acetyltransferase complexes, in cell cycle regulation, and loss of Ada3 results in mouse embryonic lethality. Here, we used adenovirus-Cre-mediated Ada3 deletion in Ada3fl/fl mouse embryonic fibroblasts (MEFs) to assess the role of Ada3 in DNA damage response following exposure to ionizing radiation (IR). We report that Ada3 depletion was associated with increased levels of phospho-ATM (pATM), γH2AX, phospho-53BP1 (p53BP1) and phospho-RAD51 (pRAD51) in untreated cells; however, radiation response was intact in Ada3−/− cells. Notably, Ada3−/− cells exhibited a significant delay in disappearance of DNA damage foci for several critical proteins involved in the DNA repair process. Significantly, loss of Ada3 led to enhanced chromosomal aberrations, such as chromosome breaks, fragments, deletions and translocations, which further increased upon DNA damage. Notably, the total numbers of aberrations were more clearly observed in S-phase, as compared with G₁ or G₂ phases of cell cycle with IR. Lastly, comparison of DNA damage in Ada3fl/fl and Ada3−/− cells confirmed higher residual DNA damage in Ada3−/− cells, underscoring a critical role of Ada3 in the DNA repair process. Taken together, these findings provide evidence for a novel role for Ada3 in maintenance of the DNA repair process and genomic stability.
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

We show that the specific subcellular distribution of H- and Nras guanosine triphosphate–binding proteins is generated by a constitutive de/reacylation cycle that operates on palmitoylated proteins, driving their rapid exchange between the plasma membrane (PM) and the Golgi apparatus. Depalmitoylation redistributes farnesylated Ras in all membranes, followed by repalmitoylation and trapping of Ras at the Golgi, from where it is redirected to the PM via the secretory pathway. This continuous cycle prevents Ras from nonspecific residence on endomembranes, thereby maintaining the specific intracellular compartmentalization. The de/reacylation cycle also initiates Ras activation at the Golgi by transport of PM-localized Ras guanosine triphosphate. Different de/repalmitoylation kinetics account for isoform-specific activation responses to growth factors.
Symbol synchronizers based on filter with Phase Lock Loop

This work studies the symbol synchronizer based on a filter followed of a carrier PLL (phase lock loop). The filter is a bandpass filter, centered in an equal frequency to the data transmission rate. We will present four symbol synchronizers, the filter is equal for all them, but the PLL can be one of four types, namely the analog, the hybrid, the combinational and the sequential. The main objective is to study the four symbol synchronizers and to obtain their jitter noise curves.
Distribution of heavy metals from iron bath‐melting separation process applied to municipal solid waste incineration fly ash

Fly ash generated from municipal solid waste (MSW) incineration is frequently classified as hazardous material and requires special disposal. The management of the large amount of fly ash has caused increasing problems in China. This work describes a novel approach for melting MSW incineration fly ash, and the distribution of heavy metals was characterized during the iron bath‐melting separation process. Four hundred grams of pelletized fly ash was fed into the furnace in molten iron bath atmosphere. After the melting separation process, the distribution of heavy metals in samples and the leaching characteristics of the slag were investigated. The results indicated that iron bath‐melting promoted the transfer of Cr, Mn and Cu from the slag phase to the iron phase, which also improved Zn and Pb volatilization. The leaching concentrations, determined by the Chinese Standard Method (rollover leaching procedure) of the target metals of the slag from leaching tests were lower than the Chinese regulatory thresholds. Therefore, this method was proposed as an environmentally friendly technology to achieve a satisfactory solution for MSW incineration fly ash management.