Miracle-dz/UniFAR-FTUs huggingface dataset:
A de novo variant in ZBTB18 gene caused autosomal dominant non-syndromic intellectual disability 22 syndrome: A case report and literature review

Rationale: Autosomal dominant non-syndromic intellectual disability 22 is a rare genetic disorder caused by the ZBTB18 gene. This disorder affects various parts of the body, leading to intellectual disability. It is noteworthy that only 31 cases of this disorder have been reported thus far. As the symptom severity may differ, doctors may face challenges in diagnosing it accurately. It is crucial to be familiar with this disorder’s symptoms to receive proper diagnosis and essential medical care. Patient concerns: There is a case report of a 6-year-old boy who had an unexplained thyroid abnormality, global developmental delay, and an abnormal signal of white matter in brain MRI. However, he did not have growth retardation, microcephaly, corpus callosum hypoplasia, epilepsy, or dysmorphic facial features. Clinical whole exome sequencing revealed a de novo pathogenic variant in the ZBTB18 gene (c.1207delC, p. Arg403Alafs*60), which is a previously unreported site. This variant causes the premature termination of peptide chain synthesis, leading to incomplete polypeptide chains. Diagnoses: Autosomal dominant non-syndromic intellectual and disability 22 syndrome and thyroid dysfunction. Interventions: Rehabilitation training. Outcomes: The individual is experiencing difficulty with their motor skills, appearing clumsier while running. He struggles with expressing themselves and forming complete sentences, relying mostly on gestures and pointing. Lessons: The clinical presentations of mental retardation, autosomal dominant, type 22 (MRD22) are complicated and varied. Although early diagnosis can be made according to typical clinical symptoms, whole exome sequencing is necessary for diagnosing MRD22, as our study indicates.
ANALISIS TINGKAT KEPUASAN PENGGUNA ONLINE PUBLIC ACCESS CATALOG (OPAC) DENGAN METODE EUCS (Studi Kasus: Perpustakaan UIN SUSKA Riau)

Penelitian ini mengenai analisis tingkat kepuasan pengguna Online Public Access Catalog (OPAC) perpustakaan UIN Suska Riau. Tujuan penelitian ini untuk mengetahui penerapan OPAC yang digunakan serta mengetahui tingkat kepuasan pengguna OPAC perpustakaan UIN Suska Riau. Penelitian ini menggunakan metode End user computing satisfaction (EUCS). Metode ini menekankan pada kepuasan (satisfaction) pengguna, dengan menganalisa sistem berdasarkan isi, keakuratan, tampilan, kemudahan pengguna dan ketepatan waktu. Jenis penelitian yang dilakukan adalah jenis penelitian deskriptif dengan menggunakan instrumen penelitian berupa angket. Objek dalam penelitian ini yaitu pemustaka sebagai pengguna OPAC pada perpustakaan UIN Suska Riau dengan jumlah 100 responden yang diambil secara acak. Analisis data dilakukan dengan teknik analisis deskriptif dengan menggunakan rentang kategori dan persentase melalui skala Likert. Hasil penelitian ini menunjukkan bahwa tingkat kepuasan pemustaka terhadap OPAC secara keseluruhan termasuk ke dalam kategori setuju-pemustaka merasa puas menggunakan OPAC,dengan nilai persentase sebesar 74,10%.
Multiple stable states of tree cover in a global land surface model due to a fire‐vegetation feedback

The presence of multiple stable states has far‐reaching consequences for a system's susceptibility to disturbances, including the possibility of abrupt transitions between stable states. The occurrence of multiple stable states of vegetation is supported by ecological theory, models, and observations. Here we describe the occurrence of multiple stable states of tree cover in a global dynamic vegetation model and provide the first global picture on multiple stable states of tree cover due to a fire‐vegetation feedback. The multiple stable states occur in the transition zones between grasslands and forests, mainly in Africa and Asia. By sensitivity simulations and simplifying the relevant model equations we show that the occurrence of multiple states is caused by the sensitivity of the fire disturbance rate to the presence of woody plant types.
A predictive model for awakening in patients with prolonged disorders of consciousness after craniocerebral injury

This study aimed to develop and validate a nomogram to predict awakening at 1 year in patients with prolonged disorders of consciousness (pDOC). We retrospectively analyzed the data of 381 patients with pDOC at 2 centers. The data were randomly divided into training and validation sets using a ratio of 6:4. For the training set, univariate and multivariate logical regression analyses were used to identify the predictive variables. Receiver operating characteristic curves, calibration curves, and a decision curve analysis were utilized to assess the predictive accuracy, discriminative ability, and clinical utility of the model, respectively. The final model included age, Glasgow Coma Scale score, serum albumin level, and computed tomography midline shift, all of which had a significant effect on awakening after pDOC. For the 1-year awakening in the training set, the model had good discriminative power, with an area under the curve of 0.733 (95% confidence interval: 0.667–0.789). For the validation set, the area under the curve for 1-year awakening was 0.721 (95% confidence interval: 0.617–0.826). Model performance was good for both the training and validation sets according to calibration plots and decision curve analysis. We developed a precise, effective nomogram to assist clinicians in better assessing patients’ outcomes, guiding clinical judgment, and personalizing the therapeutic process.
The Economics of Adaptation to Climate Change in Coasts and Oceans: Literature Review, Policy Implications and Research Agenda

Sea level rise and other effects of climate change on oceans and coasts around the world are major reasons to halt the emissions of greenhouse gases to the maximum extent. But historical emissions and sea level rise have already begun so steps to adapt to a world where shorelines, coastal populations, and economies could be dramatically altered are now essential. This presents significant economic challenges in four areas. (1) Large expenditures for adaptation steps may be required but the extent of sea level rise and thus the expenditures are unknowable at this point. Traditional methods for comparing benefits and costs are severely limited, but decisions must still be made. (2) It is not clear where the funding for adaptation will come from, which is a barrier to even starting planning. (3) The extent of economic vulnerability has been illustrated with assessments of risks to current properties, but these likely significantly understate the risks that lie in the future. (4) Market-based solutions to reducing climate change are now generally accepted, but their role in adaptation is less clear. Reviewing the literature addressing each of these points, this paper suggests specific strategies for dealing with uncertainty in assessing the economics of adaptation options, reviews the wide range of options for funding coastal adaption, identifies a number of serious deficiencies in current economic vulnerability studies, and suggests how market based approaches might be used in shaping adaptation strategies. The paper concludes by identifying a research agenda for the economics of coastal adaptation that, if completed, could significantly increase the likelihood of economically efficient coastal adaptation. This review is available in Journal of Ocean and Coastal Economics: https://cbe.miis. edu/joce/vol3/iss2/1
Discovering peptide inhibitors of thrombin as a strategy for anticoagulation

Unusual blood clots can cause serious health problems, such as lung embolism, stroke, and heart attack. Inhibiting thrombin activity was adopted as an effective strategy for preventing blood clots. In this study, we explored computational-based method for designing peptide inhibitors of human thrombin therapeutic peptides to prevent platelet aggregation. The random peptides and their 3-dimentional structures were generated to build a virtual peptide library. The generated peptides were docked into the binding pocket of human thrombin. The designed strong binding peptides were aligned with the native binder by comparative study, and we showed the top 5 peptide binders display strong binding affinity against human thrombin. The 5 peptides were synthesized and validated their inhibitory activity. Our result showed the 5-mer peptide AEGYA, EVVNQ, and FASRW with inhibitory activity against thrombin, range from 0.53 to 4.35 μM. In vitro anti-platelet aggregation assay was carried out, suggesting the 3 peptides can inhibit the platelet aggregation induced by thrombin. This study showed computer-aided peptide inhibitor design can be a robust method for finding potential binders for thrombin, which provided solutions for anticoagulation.
Geomorphological quantitative analysis of Sperchios River Basin area (Central Greece) utilizing geographical information systems.

Στην παρούσα μeλέτη πραγματοποιήθηκe η ανάλυση των μορφομeτρικών ποσοτικών παραμέτρων της λeκάνης του ποταμού Σπeρχeιού, και συγκeκριμένα των 8 κύριων υπολeκανών του βόρeιου και νότιου τμήματος. Η ολοκληρωμένη χρήση eνός Γeωγραφικού Συστήματος Πληροφοριών (GIS) eπιτρέπeι μια λeπτομeρή χωρική ανάλυση των δeδομένων που προκύπτουν από τα ψηφιακή μοντέλα eδάφους, που αναδeικνύουν τα γeωμορφολογικά χαρακτηριστικά μιας πeριοχής. Η διeξοδική ανάλυση των αποτeλeσμάτων δeίχνeι τη σημαντική διαφορά των μορφολογικών χαρακτηριστικών του βόρeιου και νότιου τμήματος της λeκάνης απορροής, λόγω της eπίδρασης της νeοτeκτονικής, όπου δημιουργeί αυτή την ασύμμeτρη τοπογραφία.
Severely stressful natal environment does not impact lifetime reproductive success of adult boobies

Although stressful natal conditions are expected to have developmental impacts that prejudice fitness, wild animals sometimes respond to early-life adversity with phenotypic resilience or make life-history adjustments that apparently mitigate fitness penalties. Whether these adjustments enable long-lived animals to completely evade impacts of natural environmental stresses experienced during early development remains uncertain. Analysis of recruits from 18 birth cohorts of the blue-footed booby (Sula nebouxii) showed that El Nino (warm-water) conditions in the natal year did not prejudice annual breeding success, fledgling viability, adult lifespan or lifetime reproductive success. This equivalence of El Nino cohorts was attributed to high average quality due to overrepresentation of young + old parental pairings, known to engender high quality fledglings, and to a possible filtering effect of greater nestling and juvenile mortality, as well as documented life history adjustments. Parents of high-quality or peak reproductive age were not overrepresented in El Nino years. In this long-lived species which faces the worlds most dramatic climatic oscillation, recruits from cohorts that faced the most severe climatic events are fully equivalent to those from cohorts that faced benign conditions, and self-selection of adults for breeding in such conditions may be a key adaptation for achieving this.
Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 19: Suitability of taxonomic units notified to EFSA until September 2023

Abstract The qualified presumption of safety (QPS) process was developed to provide a safety assessment approach for microorganisms intended for use in food or feed chains. The QPS approach is based on an assessment of published data for each taxonomic unit (TU), with respect to its taxonomic identity, the body of relevant knowledge and safety concerns. Safety concerns identified for a TU are, where possible, confirmed at the species/strain or product level and reflected by ‘qualifications’. In the period covered by this Statement, no new information was found that would change the status of previously recommended QPS TUs. Of 71 microorganisms notified to EFSA between April and September 2023 (30 as feed additives, 22 as food enzymes or additives, 7 as novel foods and 12 from plant protection products [PPP]), 61 were not evaluated because: 26 were filamentous fungi, 1 was Enterococcus faecium, 5 were Escherichia coli, 1 was a bacteriophage (all excluded from the QPS evaluation) and 28 were TUs that already have a QPS status. The other 10 notifications belonged to 9 TUs which were evaluated for a possible QPS status: Ensifer adhaerens and Heyndrickxia faecalis did not get the QPS recommendation due to the limited body of knowledge about their occurrence in the food and/or feed chains and Burkholderia ubonensis also due to its ability to generate biologically active compounds with antimicrobial activity; Klebsiella pneumoniae, Serratia marcescens and Pseudomonas putida due to safety concerns. K. pneumoniae is excluded from future QPS evaluations. Chlamydomonas reinhardtii is recommended for QPS status with the qualification ‘for production purposes only’; Clostridium tyrobutyricum is recommended for QPS status with the qualification ‘absence of genetic determinants for toxigenic activity’; Candida oleophila has been added as a synonym of Yarrowia lipolytica. The Panel clarifies the extension of the QPS status for genetically modified strains.
Relationship between depression, anxiety, stress, and health-related quality of life in adults with and without chronic diseases: A cross-sectional study

Health-related quality of life (HRQoL) in patients with chronic diseases is an important tool to measure patient-reported health outcomes and evaluate the usefulness of treatment, management, and rehabilitation programs. Patients with chronic diseases are more likely than those without to experience psychological problems such as depression, anxiety, and stress, all of which can affect HRQoL. This study evaluated the impact of psychological problems such as depression, anxiety, and stress on HRQoL in people with and without chronic diseases in South Korea. The study’s descriptive survey included 501 participants (191 with and 310 without chronic diseases). Data were collected using structured questionnaires between April and May 2021. The general characteristics, DASS-21, and HRQOL of this study were analyzed using descriptive statistics. Differences in DASS-21 and HRQoL based on general characteristics were analyzed using t tests and ANOVA. The study analyzed the factors influencing the participants’ HRQoL using stepwise multiple regression analysis with SPSS Win 27.0. HRQoL was generally lower for patients with chronic diseases than for patients without. In patients with chronic diseases, the major variables affecting HRQoL were depression (β = −0.244, t = −3.582, P < .001), exercise (β = 0.201, t = 2.927, P = .004), and economic status (β = −0.150, t = −2.184, P = .030), of which depression was the most influential. These variables explained 12.5% of the variance in the regression model for total HRQoL. These results emphasize the need to explore intervention measures that can reduce depression in patients with chronic diseases and anxiety in patients without chronic diseases to improve their HRQoL. In addition, national efforts are needed to provide economic support, as economic status is an influential factor in HRQoL regardless of the presence of chronic disease. The study’s limitations include the fact that neither did it consider disease severity among chronically ill patients nor did it examine all the variables affecting HRQoL.
Evaluation of the European Space Agency Climate Change Initiative Soil Moisture Product over China Using Variance Reduction Factor

In this study, we evaluated the European Space Agency Climate Change Initiative soil moisture product v02.1 (ESA CCI SM v02.1) using in situ observations collected at 547 stations in China from 1991 to 2013. A conventional validation was first conducted, and the triple collocation errors of ESA CCI SM and the European Centre for Medium Range Weather Forecasting reanalysis data were approximately 0.053 and 0.050 m3/m3, respectively. To obtain more reliable validation results, the average soil moisture of the in situ observations per ESA CCI SM pixel was also used as the validation sites. Variance reduction factor (VRF) was adopted to quantify the accuracy of the soil moisture validation sites, and the average VRF was estimated at 4.88%. The validation results were enhanced by excluding validation sites with VRF errors greater than 5% from the statistical analysis. Although the ESA CCI SM underestimated the in situ observations with a Bias of 0.05 m3/m3, a moderately high correlation coefficient of 0.44 and a relatively small unbiased root‐mean‐square difference of 0.05 m3/m3 were observed. This study provides information on the utilization of ESA CCI SM for ecological protection, climate change, and hydrological forecasting. It also suggests the adoption of VRF for future error corrections of satellite‐based products.
Modeling of soil water conditions as an indicator for predicting landslides in Norway

i Foreword ii 1 Introduction 1 2 Study area and data 3 2.1 Area of study 3 2.2 Model input data 10 2.3 Landslide records 12 3 Methodology 14 3.1 Model selection 14 3.2 The KiWa model 15 3.2.1 General model structure 16 3.2.2 The interception storage module 16 3.2.3 The snow routine 17 3.2. 4 The evapotranspiration routine 17 3.2. 5 Overland flow and groundwater flow 20 3.2. 6 Modifications 22 3.3 Model calibration and evaluation methods 24 3.3.1 Parameter types and values 24 3.3.2 The calibration 27 3.3.3 The validation 28 3.4 Landslide theory 29 3.4.1 Nomenclature of mass movement 29 3.4.2 Triggering factors in till soils 30 3.4. 3 Qualitative levels of landslide indicators 32 4 Results 33 4.1 KiWa model results 33 4.1. 1 Overview of results 33 4.1. 2 Validation of parameter sets 35 4.1. 3 Details of simulation results 36 4.2 Hydrological indicators for landslides 44 4.2.1 Examples of level one indications 47 4.2.2 Examples of level two indications 48 4.2.3 Examples of level three indications 55
Impact of climate change on water availability in the Near East

The impact of climate change on water availability in the Middle East and the Upper Jordan catchment (UJC) is investigated by dynamic downscaling of ECHAM4 time slices and subsequent hydrological modelling. Two time slices (1961-90 and 2070-99) of the global climate scenario B2 of ECHAM4 were dynamically downscaled with the meteorological model MM5 in two nesting steps of 54 km and 18 km resolution. The meteorological fields were used to drive a physically based hydrological model, computing in detail the surface and subsurface water flow and water balance of the UJC. Results of the joint regional climate-hydrology simulations indicate mean annual temperature increases up to 4.5° C and 25 % decreases in mean annual precipitation in the mountainous part of the UJC. Total runoff at the outlet of the catchment is predicted to decrease by 23 %, and is accompanied by significant decreasing groundwater recharge.
Performance enhancement and PAPR reduction for MIMO based QAM-FBMC systems

Filter Bank Multi-Carrier (FBMC) is attracting significant interest as a multi-carrier modulation (MCM) approach for future communication systems. It offers numerous advantages in contrast to Orthogonal Frequency Division Multiplexing (OFDM). Nonetheless, similar to many other MCM techniques, FBMC encounters a significant challenge with a high Peak-to-Average Power Ratio (PAPR). Additionally, incorporating Multiple-Input and Multiple-Output (MIMO) into FBMC presents heightened difficulties due to the presence of complex interference and increased computational complexity. In this paper, we first study the performance analysis of MIMO based Quadrature Amplitude Modulation (QAM)-FBMC systems considering the system complexity and interference. To enhance coverage effectively using beamforming with multiple antennas, it is essential to reduce PAPR to minimize the input backoff (IBO) required by nonlinear power amplifiers. Therefore, we propose new PAPR reduction method for MIMO based QAM-FBMC systems leveraging the null space within the MIMO channel using clipping and filtering (CF) technique. The PAPR reduction signals generated in this process are then mapped to the null space of the overall MIMO channel for each frequency block. Through computer simulations using a nonlinear power amplifier model, we illustrate that the proposed method substantially enhances both PAPR and throughput of MIMO based FBMC systems compared to conventional methods.
Rangelands in the 1977 Soil and Water Resources Conservation Act.

Concerned ranchers and farmers in all parts of the nation told the Federal Government in 1978 their views on the future course of soil and water conservation in the United States. They spoke out at some 8,700 public meetings, held by the U.S Department of Agriculture's Soil Conservation Service in cooperation with local conservation districts and State conservation agencies. About 160,000 people have attended and participated—individual farmers, ranchers, and rangemen; representatives of organizations and government at all levels; and other citizens with an interest in the future direction of conservation programs. The public meetings were held in response to a new law signed late in 1977, the Soil and Water Resources Conservation Act
Worldwide productivity and research trend of publications concerning intestinal polyps: A bibliometric study

There is a significant relationship between intestinal polyps and colorectal cancer, and in recent years, research on intestinal polyps has been rapidly developing around the world. However, there is still a lack of adequate quantification and analysis of publications in this field. The aim of this study was to perform a comprehensive bibliometric analysis of publications related to intestinal polyps over the past 20 years. To enhance the understanding of current research hotspots and potential trends, and to point out the direction of future research. Publications related to intestinal polyps were retrieved from the Science Citation Index Expanded in Web of Science Core Collection. the Bibliometric online analysis platform (https://bibliometric.com/app), the Bibliometrix Package, and the CiteSpace are used for bibliometric analysis and visualization, including the overall range of annual output and annual citations, country-region analysis, author and institution analysis, core journal analysis, reference and keyword analysis. Prior to 2017, the amount of research on intestinal polyps was slow to grow, but it picked up speed after that year. In 1019 journals, 4280 papers on intestinal polyps were published in English. The journal with the highest productivity was Gastrointestinal Endoscopy (189, 4.42%). United States (1124, 26.26%), which is also the hub of collaboration in this subject, was the most productive nation. Mayo Clinic (n = 70, 1.64%) is the most productive institution. Intestinal microbiota, endoscopic mucosal resection, gut microbiota, deep learning, tea polyphenol, insulin resistance and artificial intelligence were current hot subjects in the field. Studies of intestinal polyps increased significantly after 2017. The United States contributed the largest number of publications. Countries and institutions were actively cooperating with one another. artificial intelligence is currently an emerging topic.