Miracle-dz/UniFAR-FTUs huggingface dataset:
An all-at-once approach to nonnegative tensor factorizations

Tensors can be viewed as multilinear arrays or generalizations of the notion of matrices. Tensor decompositions have applications in various fields such as psychometrics, signal processing, numerical linear algebra and data mining. When the data are nonnegative, the nonnegative tensor factorization (NTF) better reflects the underlying structure. With NTF it is possible to extract information from a given dataset and construct lower-dimensional bases that capture the main features of the set and concisely describe the original data. Nonnegative tensor factorizations are commonly computed as the solution of a nonlinear bound-constrained optimization problem. Some inherent difficulties must be taken into consideration in order to achieve good solutions. Many existing methods for computing NTF optimize over each of the factors separately; the resulting algorithms are often slow to converge and difficult to control. We propose an all-at-once approach to computing NTF. Our method optimizes over all factors simultaneously and combines two regularization strategies to ensure that the factors in the decomposition remain bounded and equilibrated in norm. We present numerical experiments that illustrate the effectiveness of our approach. We also give an example of digital-inpainting, where our algorithm is employed to construct a basis that can be used to restore digital images.
Waste Valorization towards Industrial Products through Chemo- and Enzymatic- Hydrolysis

ABSTRACT This paper reviews the scientific literature on the latest technologies for treating waste by chemical hydrolysis, enzymatic hydrolysis and supporting processes. Particular attention is focused on wastes of biological origin, especially high-protein materials and those containing fats and sugars, as valuable components can be extracted from these recyclables to produce plant growth-stimulating compounds and animal feed, chemicals, biofuels or biopolymers. The wastes with the greatest potential were identified and the legislative regulations related to their processing were discussed. Chemical and enzymatic hydrolysis were compared and their main applications directions and important process parameters were indicated, as well as the need to optimize them in order to increase the efficiency of extraction of valuable components. GRAPHICAL ABSTRACT
Changes in blood pressure after catheter-based renal denervation in South Africa.

BACKGROUND Renal denervation (RDN) is an interventional treatment for patients with uncontrolled hypertension. The Global SYMPLICITY Registry (GSR) is a prospective, all-comer, world-wide registry designed to assess the safety and efficacy of RDN. We evaluated the outcomes in South African patients in the GSR over 12 months. METHODS Eligible patients with hypertension had a daytime mean blood pressure (BP) > 135/85 mmHg or night-time mean BP > 120/70 mmHg. Office and 24-hour ambulatory systolic BP reduction and adverse events over 12 months were evaluated. RESULTS South African patients (n = 36) in the GSR had a mean age of 54.4 ± 9.9 years with a median of four prescribed antihypertensive medication classes. At 12 months, mean changes in office and 24-hour ambulatory systolic BP were -16.9 ± 24.2 and -15.3 ± 18.5 mmHg, respectively, with only one adverse event recorded. CONCLUSIONS RDN safety and efficacy in South African patients were consistent with world-wide GSR results.
Functional symmetry of the aortic baroreflex in female spontaneously hypertensive rats

Background: Altered baroreflex function is well documented in hypertension; however, the female sex remains far less studied compared with males. We have previously demonstrated a left-sided dominance in the expression of aortic baroreflex function in male spontaneously hypertensive rats (SHRs) and normotensive rats of either sex. If lateralization in aortic baroreflex function extends to hypertensive female rats remains undetermined. This study, therefore, assessed the contribution of left and right aortic baroreceptor afferents to baroreflex modulation in female SHRs. Method: Anesthetized female SHRs (total n = 9) were prepared for left, right and bilateral aortic depressor nerve (ADN) stimulation (1–40 Hz, 0.2 ms, 0.4 mA for 20 s) and measurement of reflex mean arterial pressure (MAP), heart rate (HR), mesenteric vascular resistance (MVR) and femoral vascular resistance (FVR). All rats were also matched for the diestrus phase of the estrus cycle. Results: Reflex (%) reductions in MAP, HR, MVR and FVR were comparable for both left-sided and right-sided stimulation. Bilateral stimulation evoked slightly larger (P = 0.03) reductions in MVR compared with right-sided stimulation; however, all other reflex hemodynamic measures were similar to both left-sided and right-sided stimulation. Conclusion: These data show that female SHRs, unlike male SHRs, express similar central integration of left versus right aortic baroreceptor afferent input and thus show no laterization in the aortic baroreflex during hypertension. Marginal increases in mesenteric vasodilation following bilateral activation of the aortic baroreceptor afferents drive no superior depressor responses beyond that of the unilateral stimulation. Clinically, unilateral targeting of the left or right aortic baroreceptor afferents may provide adequate reductions in blood pressure in female hypertensive patients.
Omicron COVID-19 Case Estimates Based on Previous SARS-CoV-2 Wastewater Load, Regional Municipality of Peel, Ontario, Canada

We determined correlations between SARS-CoV-2 load in untreated water and COVID-19 cases and patient hospitalizations before the Omicron variant (September 2020–November 2021) at 2 wastewater treatment plants in the Regional Municipality of Peel, Ontario, Canada. Using pre-Omicron correlations, we estimated incident COVID-19 cases during Omicron outbreaks (November 2021–June 2022). The strongest correlation between wastewater SARS-CoV-2 load and COVID-19 cases occurred 1 day after sampling (r = 0.911). The strongest correlation between wastewater load and COVID-19 patient hospitalizations occurred 4 days after sampling (r = 0.819). At the peak of the Omicron BA.2 outbreak in April 2022, reported COVID-19 cases were underestimated 19-fold because of changes in clinical testing. Wastewater data provided information for local decision-making and are a useful component of COVID-19 surveillance systems.
Storm Prediction Center Forecasting Issues Related to the 3 May 1999 Tornado Outbreak

Abstract Forecasters at the Storm Prediction Center (SPC) were faced with many challenges during the 3 May 1999 tornado outbreak. Operational numerical forecast models valid during the outbreak gave inaccurate, inconsistent, and/or ambiguous guidance to forecasters, most notably with varying convective precipitation forecasts and underforecast wind speeds in the middle and upper troposphere, which led forecasters (in the early convective outlooks) to expect a substantially reduced tornado threat as compared with what was observed. That, combined with relatively weak forecast and observed low-level convergence along a dryline, contributed to much uncertainty regarding timing and location of convective initiation. As a consequence, as the event approached, observational diagnosis and analysis became more important and were critical in identification of the evolution of the outbreak. Tornadic supercells ultimately developed earlier, were more numerous, and produced more significant tornadoes than anticipated.
‘That’s as hard a decision as you will ever have to make’: the experiences of people who discussed Do Not Attempt Cardiopulmonary Resuscitation on behalf of a relative during the COVID-19 pandemic

Abstract Background COVID-19 brought additional challenges to Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) decision-making, which was already a contentious issue. In the UK, reports of poor DNACPR decision-making and communication emerged in 2020, including from the regulator, the Care Quality Commission. This paper explores the experiences of people who discussed DNACPR with a healthcare professional on behalf of a relative during the coronavirus pandemic, with the aim of identifying areas of good practice and what needs to be improved. Methods a total of 39 people participated in semi-structured interviews via video conferencing software or telephone. Data were evaluated using Framework Analysis. Findings results are presented around three main themes: understanding, communication and impact. Participants’ understanding about DNACPR was important, as those with better understanding tended to reflect more positively on their discussions with clinicians. The role of relatives in the decision-making process was a frequent source of misunderstanding. Healthcare professionals’ communication skills were important. Where discussions went well, relatives were given clear explanations and the opportunity to ask questions. However many relatives felt that conversations were rushed. DNACPR discussions can have a lasting impact—relatives reported them to be significant moments in care journeys. Many relatives perceived that they were asked to decide whether their relative should receive CPR and described enduring emotional consequences, including guilt. Conclusion the pandemic has illuminated deficiencies in current practice around DNACPR discussion, which can have difficult to anticipate and lasting negative consequences for relatives. This research raises questions about the current approach to DNACPR decision-making.
Shaping microbiology for 75 years: highlights of research published in Microbiology. Part 2 - Communities and evolution

Received 14 June 2023; Published 28 June 2023 Author affiliations: Division of Evolution, Infection and Genomics, University of Manchester, Michael Smith Building, Dover Street, Manchester M13 9PT, UK; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK; Center for Microbial Dynamics & Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy; Institute of Physiology of the Czech Academy of Sciences, Laboratory of Membrane Transport, 14200 Prague 4, Czech Republic; Institut Universitaire de France, Paris, France; Department of Biochemistry, University of Cambridge, Cambridge, UK; Microbes in Health and Disease Theme, Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK; Department of Biology, University of York, Wentworth Way, York, UK. *Correspondence: Gavin H. Thomas, gavin. thomas@ york. ac. uk Abbreviations: AHL, Nacyl homoserine lactone; AI, artificial intelligence; BAC, bacterial artificial chromosome; CF, cystic fibrosis; HPLC, high pressure liquid chromatography; LPS, lipopolysaccharide; LTEE, longterm evolution experiment; Mtb, Mycobacterium tuberculosis; NFL, Nitrogen Fixation Laboratory; QS, quorum sensing; TLC, thin layer chromatography; UTI, urinary tract infection. 001357 © 2023 The Authors
Parental developmental screening with CARE: A pilot hybrid assessment and intervention with vulnerable families in Colombia

Poverty and scarcity of resources make children in low-and-middle-income countries at risk of not reaching their developmental potential. Despite a near-universal interest in risk reduction, effective interventions like enhancing reading skills in parents to diminish developmental delay remain elusive for the great majority of vulnerable families. We undertook a efficacy study for parental use of a booklet called CARE for developmental screening of children between 36 to 60 months old (M = 44.0, SD = 7.5). All participants (N = 50), lived in vulnerable, low-income neighborhoods in Colombia. The study followed a pilot Quasi-Randomised Control Trial design (i.e., control group participants assigned based on non-random criteria) of parent training with a CARE intervention group compared to a control group. Data was analyzed using two-way ANCOVA for sociodemographic variables’ interaction with follow-up results and one-way ANCOVA to evaluate the relations between the intervention and post-measurement of developmental delays and cautions and other language related-skills outcomes, while controlling for pre-measurements. These analyses indicated that the CARE booklet intervention enhanced children’s developmental status and narrative skills (developmental screening delay items, F(1, 47) = 10.45, p = . 002, partial η2 = . 182; narrative devices scores, F(1, 17) = 4.87, p = . 041, partial η2 = . 223). Several limitations (e.g., sample size) and possible implications for the analysis of children’s developmental potential are discussed and considered for future research, along with the effects of the COVID-19 pandemic on the closure of preschools and community care centers.
Relationships Between Adherence to Guideline Recommendations for Pharmacological Therapy Among Clinicians and Psychotic Symptoms in Patients With Schizophrenia

Abstract Background Clinician adherence to guideline recommendations in the pharmacological therapy of schizophrenia is important for favorable patient outcomes. To evaluate whether prescriptions followed the guidelines for pharmacological therapy of schizophrenia, we recently developed a summary indicator of multiple quality indicators: the individual fitness score (IFS). It is unclear whether adherence to the guidelines is related to patient outcomes. Here, we investigated correlations between the IFS values and psychotic symptoms in patients with schizophrenia. Methods We assessed whether patients’ current prescriptions adhered to the guideline recommendations using the IFS in 47 patients with treatment-resistant schizophrenia (TRS) and 353 patients with non-TRS (total n = 400), respectively. We investigated correlations between the IFS and total scores and scores on the 5 subscales of the Positive and Negative Syndrome Scale (PANSS). Furthermore, we explored correlations between over 2-year longitudinal changes in IFS values and changes in psychotic symptoms in some patients (n = 77). Results We found significant negative correlation between the IFS and PANSS total score in all patients with schizophrenia (β = −0.18, P = 9.80 × 10−5). The IFS was significantly and nominally negatively correlated with the PANSS total score in patients with non-TRS (Spearman’s rho = −0.15, P = 4.40 × 10−3) and patients with TRS (rho = −0.37, P = .011), respectively. The IFS was also significantly and nominally negatively correlated with several factors, such as the negative and depressed factors, in patients with non-TRS and patients with TRS, respectively (P < .05). Furthermore, the change in IFS values was marginally negatively correlated with the changes in PANSS total scores and scores on the positive and depressed factors (P < .05). Conclusions These findings suggest that efforts to improve clinician adherence to guideline recommendations for pharmacological therapy of schizophrenia, as assessed by the IFS, may lead to better outcomes in patients with schizophrenia.
Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

ABSTRACT The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders. Here, we demonstrate that the transport of human antibodies across the BBB in mice can be enhanced by modulating their interactions with the neonatal Fc receptor (FcRn). When M252Y/S254T/T246E substitutions are introduced on the antibody Fc domain, immunohistochemical assays reveal widespread distribution of the engineered antibodies throughout the mouse brain. These engineered antibodies remain specific for their antigens and retain pharmacological activity. We propose that novel brain-targeted therapeutic antibodies can be engineered to differentially engage FcRn for receptor-mediated transcytosis across the BBB in order to improve neurological disease therapeutics in the future.
In Vivo Multithread Ultrasound Thermal Strain Imaging

While thermal therapy is increasingly applied in clinics, real-time temperature monitoring in the target tissue can facilitate improvements in the planning, controlling, and evaluating of therapeutic procedures. Thermal strain imaging (TSI), based on tracking the echo shifts in ultrasound images, has great potential for temperature estimation as is demonstrated in vitro. However, due to physiological motion-induced artifacts and estimation errors, employing TSI for in vivo thermometry is still challenging. Building on our earlier development of respiration-separated TSI (RS-TSI), a multithread TSI (MT-TSI) approach is proposed as the first part of a bigger plan. A flag image frame is first identified by analyzing the correlation between ultrasound images. Then, the quasi-periodic phase profile of respiration is determined and split into multiple parallelly distributed periodical subranges. Multiple threads of independent TSI calculations are thus established, with image matching, motion compensation, and thermal strain estimation performed in each thread. Finally, after applying temporal extrapolation, spatial alignment, and interthread noise suppression, the TSI results obtained in different threads are averaged to obtain the merged output. In microwave (MW) heating experiments targeting porcine perirenal fat, the thermometry accuracy of MT-TSI is comparable to that of RS-TSI, while the former exhibits lower noise and higher temporal density.
On a distance function between Differentiable structures

In this note, we investigate a relation between the connected sum of manifolds and the distance of manifolds ([2]). Since the smoothing of a piecewise linear equivalence is given by connected sum of exotic spheres ([1]), we have a certain estimate of the smoothing obstruction using the distance of manifolds (Proposition 3). In § 3, an application is given to show the impossibility of the 0.64-pinching of an exotic sphere.
Targeting Ribonucleases with Small Molecules and Bifunctional Molecules

Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis, metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules targeting RNases have the potential to perturb RNA biology, and RNases have been studied as therapeutic targets of antibiotics, antivirals, and agents for autoimmune diseases and cancers. Additionally, the recent advances in chemically induced proximity approaches have led to the discovery of bifunctional molecules that target RNases to achieve RNA degradation or inhibit RNA processing. Here, we summarize the efforts that have been made to discover small-molecule inhibitors and activators targeting bacterial, viral, and human RNases. We also highlight the emerging examples of RNase-targeting bifunctional molecules and discuss the trends in developing such molecules for both biological and therapeutic applications.
Possibilistic missing data estimation

An approach that deals with the heterogeneity and the imperfection of information elements which constitute the objects in large databases has been proposed in this paper. Unlike the prior works that separately tackle these aspects using complex and conditional techniques, our method is general and takes account of them within a simple, flexible, and robust unified framework. It is fundamentally based on two fuzzy monotone measures: the possibility and the necessity degrees introduced in the theory of possibilities. A simple concrete example will also be given to clarify and to simply illustrate the main steps of computation, pointing out the outperformance and the robustness of the proposed strategy.
Phase-field-based simulation of axisymmetric binary fluids by using vorticity-streamfunction formulation

We propose a numerical method for the simulation of axisymmetric binary fluids based on the phase-field theory and vorticity-streamfunction formulation. Unlike most existing methods that solve the incompressible Navier-Stokes equations in the velocity-pressure form, we recast the equations into the vorticity-streamfunction form, which only need to treat one evolution equation of the vorticity for two-dimensional (2-D) or axisymmetric (pseudo 2-D) problems. Besides, this formulation enforces the continuity equation more easily. This method is verified through a series of benchmark problems under axisymmetric conditions, including the Laplace relation for a quiescent drop, coalescence of two drops, and the contact angle of a drop on a smooth wall with given wettability. Good agreements with theoretical relations or another numerical method are achieved for all these problems.
Development and characterization of antimicrobial alginate hydrogel beads filled with cinnamon essential oil nanoemulsion

Abstract The aim of the present study was to investigate the characteristics of alginate beads filled with cinnamon essential oil nanoemulsions (CEONs). The influence of the alginate and CaCl2 concentrations on their physical, antimicrobial and antioxidant properties was studied. The droplet size of CEON was 146.20 ± 39.28 nm and the zeta potential was −33.8 ± 0.72 mV demonstrating proper nanoemulsions stability. Decreasing the alginate and CaCl2 concentrations resulted in higher EOs release due to the increased pore size of the alginate beads. The scavenging activity of DPPH of beads was found to be dependent on the alginate and calcium ion concentrations which affected the pore size of the fabricated beads. The FT-IR results declared the new bands in the spectra of filled hydrogel beads, which verified the encapsulation of EOs in the beads. The surface morphology of beads was studied using SEM images which showed the spherical shape and porous structure of alginate beads. In addition, the alginate beads filled with CEO nanoemulsion demonstrated strong antibacterial activity.
Why Are Individuals Who Have Not Disclosed Self-Injury Comfortable Discussing Their Experiences in Research?

Abstract Not everyone who shares their lived experience of nonsuicidal self-injury (NSSI) in research has disclosed this previously outside of a research context. Our objective was to identify reasons people who have not previously disclosed their NSSI felt comfortable discussing their self-injury in research contexts. The sample consisted of 70 individuals with lived experience of self-injury who had not previously disclosed this experience outside of research (Mage = 23.04 years, SD = 5.90; 75.70% women). Using content analysis of open-ended responses, we identified three reasons participants felt comfortable discussing their NSSI in research. Most commonly, participants did not anticipate negative consequences discussing their NSSI due to the way the research was conducted (e.g., confidentiality). Second, participants valued NSSI research and wanted to contribute to such work. Third, participants referenced feeling mentally and emotionally prepared to discuss their NSSI. The findings indicate that individuals who have not previously disclosed their NSSI may wish to discuss their experience in research for a variety of reasons. Such findings highlight implications for how we foster safe spaces in research for people with lived experience of NSSI.