Miracle-dz/UniFAR-FTUs huggingface dataset:
A Theory of Privacy and Utility in Databases

Ensuring the usefulness of electronic data sources while pr oviding necessary privacy guarantees is an important unsolved problem. This problem drives the need for an overarching analytical framework that can quantify the safety of personally identifiable info rmation (privacy) while still providing a quantifable benefit (utility) to multiple legitimate infor mation consumers. State of the art approaches have predominantly focused on privacy. This paper presents the first information-theoretic approach that promises an analytical model guaranteeing tight bounds on h ow much utility is possible for a given level of privacy and vice-versa. Index Terms Information privacy, utility, databases, information the ory, rate distortion theory.
Prevalence rates of comorbid disorders in attention deficit hyperactivity disorder adults

Although there has been extensive research on attention deficit hyperactivity disorder as a clinical disorder in adulthood, many clinicians remain sceptical about the validity of this disorder. Among the many reasons for this are comorbid conditions which may complicate the disorder. The aim of this study was to determine the prevalence rates of other disorders among a group of adults with attention deficit hyperactivity disorder, based on participants’ scores on the Million Clinical Multiaxial Inventory-III. In order to meet this aim, the Million Clinical Multiaxial Inventory -III results of a group of adults with attention deficit hyperactivity disorder (n = 51) were analysed. In terms of Cluster B personality disorders, the following prevalence rates were found for the attention deficit hyperactivity disorder group: 23% Borderline, 27.4% Antisocial, 19.6% Histrionic, and 19.6% Narcissistic. As far as comparing prevalence rates of possible comorbid conditions, as found in this study, with those of previous studies, the results compare well to those conditions that are reported as the most prevalent in other studies. However, the wide range of clinical and personality disorders that are associated with attention deficit hyperactivity disorder indicate that there are no typical comorbid disorders.
Transmission line and electromagnetic models of the Mykonos-2 accelerator

Mykonos is a linear transformer driver (LTD) pulsed power accelerator currently undergoing testing at Sandia National Laboratories. Mykonos-2, the initial configuration, includes two 1-MA, 200-kV LTD cavities driving a water-filled transmission line terminated by a resistive load. Transmission line and 3D electromagnetic (EM) simulation models of high-current LTD cavities have been developed [D.V. Rose et al. Phys. Rev. ST Accel. Beams 13, 90401 (2010)]. These models have been used to develop an equivalent two-cavity transmission line model of Mykonos-2 using the BERTHA transmission line code. The model explicitly includes 40 bricks per cavity and detailed representations of the water-filled transmission line and resistive load. (A brick consists of two capacitors and a switch connected in series.) This model is compared to 3D EM simulations of the entire accelerator including detailed representations of the individual capacitors and switches in each cavity. Good agreement is obtained between the two simulation models and both models are in good agreement with preliminary data from Mykonos-2.
Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection.

BACKGROUND Herpesvirus-like DNA sequences have recently been found in lesions from patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS). It is not known whether these sequences are also present in classic Kaposi's sarcoma or in the Kaposi's sarcoma that occurs in homosexual men who are seronegative for the human immunodeficiency virus (HIV). METHODS We analyzed DNA in tissue samples from patients with AIDS-associated Kaposi's sarcoma, patients with classic Kaposi's sarcoma, and HIV-seronegative homosexual men with Kaposi's sarcoma. We also analyzed DNA in samples of uninvolved tissue from these patients and in control tissue from healthy subjects. All samples were tested blindly by polymerase chain reaction (PCR) with specific primers to amplify KS330(233), a herpesvirus-like DNA sequence. RESULTS The KS330(233) PCR product was found in 20 of 21 tissue samples (95 percent) from the patients with Kaposi's sarcoma, including 10 of the 11 samples from the patients with AIDS-associated Kaposi's sarcoma, all 6 samples from the patients with classic Kaposi's sarcoma, and all 4 samples from the HIV-negative homosexual men with Kaposi's sarcoma. Only 1 of the 21 control samples (5 percent) was positive (odds ratio, 400; 95 percent confidence interval, 19 to 17,300). Of the 14 samples of uninvolved skin from the patients with Kaposi's sarcoma, 3 were positive for KS330(233). Representative PCR-product sequences were more than 98 percent identical for the three types of Kaposi's sarcoma, suggesting that all three are caused by the same agent. CONCLUSIONS The same herpesvirus-like DNA sequences are present in AIDS-associated Kaposi's sarcoma, classic Kaposi's sarcoma, and the Kaposi's sarcoma that occurs in HIV-negative homosexual men. Therefore, this presumably new human herpesvirus is not solely an opportunistic infection in patients with AIDS, and the three forms of Kaposi's sarcoma may be caused by the same infectious agent.
Women as leaders of higher education institutions: a British–German comparison

Across the vast majority of countries women are a significant minority in senior academic positions, and as of 2013 only 17% of vice chancellors (VCs) of UK universities and 12% of German Universities were women. This paper discusses findings from a study consisting of interviews with eight female VCs of British and German higher education institutions. The paper takes a feminist poststructuralist approach to look at the ways in which characteristics of ‘ideal’ leaders in academia are discursively produced in a myriad of gendered ways, and looks at the influence of dominant academic cultures, status of institutions and national policy landscapes. From an analysis of the findings we argue that in addition to increasing the numerical proportion of women leaders in academia, work also crucially needs to be done to challenge academic cultural practices and dominant gendered conceptualisations of the ‘leader’.
Modulatory role of soya beans supplement on lipid profiles and liver enzymes on alloxan-induced diabetic wistar rats

This study evaluates the modulatory role of soya be ans supplement on lipid profiles and liver enzymes on alloxaninduced diabetic Wistar rats. Twenty Wistar Rats of both sexes weighed between 120-150 grams were used for the study. Induction of diabetes was done by single int raperitoneal injection of Alloxan monohydrate at a dose of 150mg/kg body weight. The animals were fed with 25% and 50% soya bean as supplements for a period two weeks. Glibenclamide was used as a standard anti-diabetic drug and was given orally. At the end of the two we eks of treatment, the animals were sacrificed and blood se rum samples were taken from all the groups for the determinations of lipid profiles and liver enzymes. As regards to the lipid profiles there was a signi ficant decrease (P<0.05) in the serum levels of TG and TC in the so ya beans supplemented groups when compared with the control unsupplemented group, while there was a significan t increase in the serum level of HDL . In relatio n to the liver enzymes there was a significant decrease (p<0.05) i n serum levels of AST,ALP and ALT in the soya bean s fed groups when compared to the control group.
Optical Position Stabilization of an UAV for Autonomous Landing

Vertical Take-Off and Landing (VTOL) capable Mini Unmanned Aerial Vehicles (MUAV) are an economic alternative to real helicopters if local aerial pictures or other aerial measurements are needed. With electronic stabilization, GPS based position-hold and autonomous way-point functions these systems are easy to operate. While autonomous take off and flying are done routinely, this is not true for autonomous landing. GPS based position stabilization, in conjunction with the normally used cheap and small IMUs, is not accurate enough to avoid dangerous moves in the very last moment of the landing operation. While sufficient for an emergency landing this is not suitable as routine operation. In this paper a solution is presented which uses optical flow techniques for position stabilization in the moment just before the touch down to avoid the inaccuracies from the GPS at this critical moment.
Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

In recent years, the central nervous system (CNS) has emerged as a principle site of insulin action. This notion is supported by studies in animals relying on intracerebroventricular insulin infusion and by experiments in humans that make use of the intranasal pathway of insulin administration to the brain. Employing neurobehavioural and metabolic measurements as well as functional imaging techniques, these studies have provided insight into a broad range of central and peripheral effects of brain insulin. The present review focusses on CNS effects of insulin administered via the intranasal route on cognition, in particular memory function, and whole‐body energy homeostasis including glucose metabolism. Furthermore, evidence is reviewed that suggests a pathophysiological role of impaired brain insulin signaling in obesity and type 2 diabetes, which are hallmarked by peripheral and possibly central nervous insulin resistance, as well as in conditions such as Alzheimer's disease where CNS insulin resistance might contribute to cognitive dysfunction.
Control of Gear Transmission Servo Systems With Asymmetric Deadzone Nonlinearity

This brief deals with the output control problem of gear transmission servo systems with asymmetric deadzone nonlinearity between states. To overcome the difficulty of controller design due to the nondifferentiability of the deadzone, a brand new differentiable asymmetric deadzone model is put forward, which provides an additional design degree of freedom to approximate the real deadzone with any prescribed accuracy. Based on the differentiability of the new model, a global differential homeomorphism and a simple state feedback controller are proposed to solve the output control problem. Finally, simulation studies are included to demonstrate the main results of this brief.
In vitro production of alkaloids: Factors, approaches, challenges and prospects

The wide diversity of plant secondary metabolites is largely used for the production of various pharmaceutical compounds. In vitro cell tissue or organ culture has been employed as a possible alternative to produce such industrial compounds. Tissue culture techniques provide continuous, reliable, and renewable source of valuable plant pharmaceuticals and might be used for the large-scale culture of the plant cells from which these secondary metabolites can be extracted. Alkaloids are one of the most important secondary metabolites known to play a vital role in various pharmaceutical applications leading to an increased commercial importance in recent years. The tissue culture techniques may be utilized to improve their production of alkaloids via somaclonal variations and genetic transformations. The focus of this review is toward the application of different tissue culture methods/techniques employed for the in vitro production of alkaloids with a systematic approach to improve their production.
JUSTICE AND ORGANIZATIONAL CITIZENSHIP: INTERACTIVE EFFECTS OF IMPRESSION MANAGEMENT MOTIVES.

We investigated linkages between employees' justice perceptions and organizational citizenship behavior (OCB). As hypothesized, distributive justice was positively related to OCB when employees were low in fear of negative evaluation (i.e., low in impression management motivation) and procedural justice was positively related to OCB across levels of impression management motivation.
Seroprotection after hepatitis B vaccination in children aged 1 to 15 years in central province of Iran, Semnan

Summary Introduction. There are controversies over the long-term persistence of post vaccination immunity to hepatitis B and the need for booster doses of the vaccine. The aim of this study was to verify antibody levels of antibody against hepatitis B virus surface antigen (anti-HBs) in children aged 1 to 15 years who received vaccination against hepatitis B in the central province of Iran, Semnan. Materials and methods. We performed a seroepidemiological survey (n = 210) of anti-HBs in 2011 in the central province of Iran, Semnan using enzyme-linked immunosorbent assay (ELISA). The levels of anti-HBs < 10 mIU/mL were considered to be negative and samples showing an anti-HBs titer ≥ 10 mIU/mL was considered protective. Results. Protective antibody levels were detected in 88% of the children less than 5 year after vaccination, decreased to 78% between 5 to 10 years after vaccination, and further declined to 74% in 10 years after vaccination, respectively. Conclusion. The vaccination program has been proven effective in Semnan and immunological protection against hepatitis B infection was found in the majority of children even more than 10 years after being vaccinated.
Distributed under Creative Commons Cc-by 4.0 Gall-id: Tools for Genotyping Gall-causing Phytopathogenic Bacteria

Understanding the population structure and genetic diversity of plant pathogens, as well as the effect of agricultural practices on pathogen evolution, is important for disease management. Developments in molecular methods have contributed to increase the resolution for accurate pathogen identification, but those based on analysis of DNA sequences can be less straightforward to use. To address this, we developed Gall-ID, a web-based platform that uses DNA sequence information from 16S rDNA, multilocus sequence analysis and whole genome sequences to group disease-associated bacteria to their taxonomic units. Gall-ID was developed with a particular focus on gall-forming bacteria belonging to Agrobacterium, Pseudomonas savastanoi, Pantoea agglomerans, and Rhodococcus. Members of these groups of bacteria cause growth deformation of plants, and some are capable of infecting many species of field, orchard, and nursery crops. Gall-ID also enables the use of high-throughput sequencing reads to search for evidence for homologs of characterized virulence genes, and provides downloadable software pipelines for automating multilocus sequence analysis, analyzing genome sequences for average nucleotide identity, and constructing core genome phylogenies. Lastly, additional databases were included in Gall-ID to help determine the identity of other plant pathogenic bacteria that may be in microbial communities associated with galls or causative agents in other diseased tissues of plants. The URL for Gall-ID
On Surface Approximation Using Developable Surfaces

We introduce a method for approximating a given surface by a developable surface. It will be either aG1surface consisting of pieces of cones or cylinders of revolution or aGrNURBS developable surface. Our algorithm will also deal properly with the problems of reverse engineering and produce robust approximation of given scattered data. The presented technique can be applied in computer aided manufacturing, e.g. in shipbuilding.
From Termination to Complexity Analysis with Monotonicity Constraints

Intuitively, if we can prove that a program terminates, we expect some conclusion regarding its complexity. But the passage from termination proofs to complexity bounds is not always clear. In this work we consider Monotonicity Constraint Systems, a program abstraction where termination is decidable (based on the size-change termination principle). We show that these programs also have a decidable complexity property: one can determine whether the length of all transition sequences can bounded in terms of the initial state. We show that if it can be bounded, the bound is polynomial. Depending on how the abstract program represents a concrete program, such a bound may have different implications on the concrete program’s complexity. In fact, we can characterize PTIME, PSPACE and EXPTIME by appropriate abstractions plus the bounded termination criterion. We argue that, augmented with certain heuristics for efficiency and precision, this approach may be useful for practical complexity analysis of programs. Keywords-Cost Analysis; Size-change termination; Implicit Computational Complexity
Inhibition of Keratinocyte Differentiation by the Synergistic Effect of IL-17A, IL-22, IL-1α, TNFα and Oncostatin M

Keratinocyte differentiation program leading to an organized epidermis plays a key role in maintaining the first line of defense of the skin. Epidermal integrity is regulated by a tight communication between keratinocytes and leucocytes, particularly under cytokine control. Imbalance of the cytokine network leads to inflammatory diseases such as psoriasis. Our attempt to model skin inflammation showed that the combination of IL-17A, IL-22, IL-1α, OSM and TNFα (Mix M5) synergistically increases chemokine and antimicrobial-peptide expression, recapitulating some features of psoriasis. Other characteristics of psoriasis are acanthosis and down-regulation of keratinocyte differentiation markers. Our aim was to characterize the specific roles of these cytokines on keratinocyte differentiation, and to compare with psoriatic lesion features. All cytokines decrease keratinocyte differentiation markers, but IL-22 and OSM were the most powerful, and the M5 strongly synergized the effects. In addition, IL-22 and OSM induced epidermal hyperplasia in vitro and M5 induced epidermal thickening and decreased differentiation marker expression in a mouse model, as observed in human psoriatic skin lesions. This study highlights the precise role of cytokines in the skin inflammatory response. IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.
Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia.

The clinical aspects of disease progression in chronic myelogenous leukemia (CML) are well established, but the nature of the molecular events responsible is not known. We have previously reported a consistent pattern of novel sites of methylation in the 5' region of the calcitonin (CT) gene and other chromosome 11p loci in acute myelogenous and and lymphoid leukemias. In the present study, CT gene methylation patterns were investigated in peripheral blood from 51 patients with CML. Abnormal patterns were found in only 2 of 31 patients in chronic phase, but in 5 of 8 patients in accelerated phase, and in 11 of 12 patients in blast crisis (P less than .005). For one patient studied in blast crisis, abnormal CT gene methylation was found in the peripheral blast cells but not in the granulocytes. In two of three patients studied with CML and having normal peripheral cell patterns, abnormal patterns were found in marrow blast cells. In one patient, only partial normalization of the CT gene methylation pattern was seen after chemotherapy induction of a second chronic phase and the patient relapsed 5 months later. Our findings indicate that abnormal methylation of the 5' region of the CT gene is regularly a marker of disease progression in CML which may prove clinically useful. This abnormal methylation site is part of an imbalance in DNA methylation that may play a role in the progressive genetic instability which characterizes the advancing stages of CML.
Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation

Objectives: To analyse circulating concentrations of advanced glycation end products (AGEs) in patients with severe congestive heart failure (CHF) and after heart transplantation; to identify the potential contribution of kidney function to plasma AGE concentrations; and to determine whether AGE concentrations and parameters of oxidative stress are interrelated. Methods and results: Circulating Nε-(carboxymethyl)lysine (CML) and AGE associated fluorescence (AGE-Fl), lipid peroxidation, and glomerular filtration rate (GFR) were measured in a cross sectional study of 22 patients with advanced CHF, 30 heart transplant recipients, and 20 healthy controls. Compared with the controls, the CHF patients had decreased CML (mean (SEM) 467.8 (20.0) ng/ml v 369.3 (22.3) ng/ml, p < 0.01), AGE-Fl (mean (SEM) 302.2 (13.3) arbitrary units v 204.9 (15.7) arbitrary units, p < 0.01), and GFR (p < 0.01). CML was positively related to decreased total protein and serum albumin and negatively to body mass index (p < 0.01). In contrast, in the heart transplant group, impaired GFR was associated with a notable rise of both CML (mean (SEM) 876.1 (53.1) ng/ml, p < 0.01) and AGE-Fl (mean (SEM) 385.6 (26.1) arbitrary units, p < 0.01). A positive relation between CML and serum albumin (r = 0.394, p < 0.05) and lipofuscin (r = 0.651, p < 0.01) was found. Conclusions: The contrasting concentration of CML and AGE-Fl between patients with CHF and after heart transplantation in the presence of decreased GFR and oxidative stress are explained by lowered plasma proteins in CHF and higher concentrations in heart transplant recipients. In heart transplant recipients, in addition to myocardial inflammatory processes, immunosuppression may be important for enhanced formation of AGEs.
Expression and Localization of Brain-Derived Neurotrophic Factor (BDNF) mRNA and Protein in Human Submandibular Gland

Brain-derived neurotrophic factor (BDNF) promotes cell survival and differentiation in the central and peripheral nervous systems. Previously, we reported that BDNF is produced by salivary glands under acute immobilization stress in rats. However, expression of BDNF is poorly understood in humans, although salivary gland localization of BDNF in rodents has been demonstrated. In the present study, we investigated the expression and localization of BDNF in the human submandibular gland (HSG) using reverse transcription-polymerase chain reaction, western blot analysis, in situ hybridization (ISH), immunohistochemistry (IHC), and ELISA. BDNF was consistently localized in HSG serous and ductal cells, as detected by ISH and IHC, with reactivity being stronger in serous cells. In addition, immunoreactivity for BDNF was observed in the saliva matrix of ductal cavities. Western blotting detected one significant immunoreactive 14 kDa band in the HSG and saliva. Immunoreactivities for salivary BDNF measured by ELISA in humans were 40.76±4.83 pg/mL and 52.64±8.42 pg/mL, in men and women, respectively. Although salivary BDNF concentrations in females tended to be higher than in males, the concentrations were not significantly different. In conclusion, human salivary BDNF may originate from salivary glands, as the HSG appears to produce BDNF.