Miracle-dz/UniFAR-FTUs huggingface dataset:
Behavioural management of migraine

It is important to recognise that migraine is a ‘biological’ and not a ‘psychological’ entity. However, psychological factors can be involved in migraine in 4 different ways:- 1) Migraines can be triggered by psychological stressors; 2) Severe migraine can itself be a cause of significant psychological stress which can, in turn, exacerbate the problem; 3) Even if psychological stress is not significantly involved in the genesis of the headache, pain management techniques can help people cope with their pain more effectively; 4) Longitudinal data demonstrate a complex bidirectional association between mood disorders and migraine. Treatment of a co-existing mood disorder, for example with cognitive behavioural techniques, may therefore reduce the impact of migraine. It would thus appear logical to view medical and psychological approaches as potentially synergistic rather than mutually exclusive. Functional imaging indicates that cognition, emotions, and pain experiences change the way the brain processes pain inputs. This may provide a physiological rationale for psychological interventions in pain management. As most studies of psychological management of migraine have been relatively small and the approach often varies between clinicians, the magnitude of benefit, optimum method of delivery, and the length of intervention are uncertain.
Eosinophilic and Neutrophilic Airway Inflammation in the Phenotyping of Mild-to-Moderate Asthma and Chronic Obstructive Pulmonary Disease

ABSTRACT Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with different inflammatory phenotypes. Various inflammatory mediators play a role in these diseases. The aim of this study was to analyze the neutrophilic and eosinophilic airway and systemic inflammation as the phenotypic characterization of patients with asthma and COPD. Twenty-four patients with asthma and 33 patients with COPD were enrolled in the study. All the patients were in mild-to-moderate stage of disease, and none of them were treated with inhaled corticosteroids. Concentrations of IL-6, neutrophil elastase (NE), matrix metalloproteinase 9 (MMP-9), eosinophil cationic protein (ECP), and IL-33 and IL-17 in serum and induced sputum (IS) were measured by enzyme-linked immunosorbent assay (ELISA). The cellular composition of blood and IS was evaluated. Hierarchical clustering of patients was performed for the combination of selected clinical features and mediators. Asthma and COPD can be differentiated based on eosinophilic/neutrophilic systemic or airway inflammation with unsatisfactory efficiency. Hierarchical clustering of patients based on blood eosinophil percentage and clinical data revealed two asthma clusters differing in the number of positive skin prick tests and one COPD cluster with two subclusters characterized by low and high blood eosinophil concentrations. Clustering of patients according to IS measurements and clinical data showed two main clusters: pure asthma characterized by high eosinophil/atopy status and mixed asthma and COPD cluster with low eosinophil/atopy status. The neutrophilic phenotype of COPD was associated with more severe airway obstruction and hyperinflation.
A semantic approach to the dynamic design of interaction controls in conversation systems

To support a full-fledged, multimedia human-computer conversation, we are building an intelligent framework, called Responsive Information Architect (RIA), which can automatically synthesize multimedia responses during the conversation. As part of its visual response generation, RIA dynamically creates context-sensitive interaction controls that are visual interfaces through which users can further interact with RIA. To enable the systematic design of inter¿action controls, we study and abstract control properties. In particular, in this paper we present a semantic model that captures the intentional, presentational, and behavioral char¿acteristics of interaction controls. Using this model, we show how to systematically sketch the semantics of an interaction control.
Poor Early Virologic Performance and Durability of Abacavir-based First-line Regimens for HIV-infected Children

Background: Concerns about stavudine (d4T) toxicity have led to increased use of abacavir (ABC) in first-line pediatric antiretroviral treatment (ART) regimens. Field experience with ABC in ART-naïve children is limited. Methods: Deidentified demographic, clinical and laboratory data on HIV-infected children initiating ART between 2004 and 2011 in a large pediatric HIV treatment program in Johannesburg, South Africa, were used to compare viral suppression at 6 and 12 months by initial treatment regimen, time to suppression (<400 copies/mL) and rebound (>1000 copies/mL after initial suppression). Adjusted logistic regression was used to investigate confounders and calendar effects. Results: Two thousand thirty-six children initiated either d4T/3TC- or ABC/3TC-based first-line regimens in combination with either boosted lopinavir (LPV/r) or efavirenz (EFV). 1634 received d4T regimens (LPV/r n = 672; EFV n = 962) and 402 ABC regimens (LPV/r n = 192; EFV n = 210). At 6 and 12 months on ART, viral suppression rate was poorer in ABC versus d4T groups within both the LPV/r and EFV groups (P < 0.0001 for all points). In ABC groups, time to suppression was significantly slower (log-rank P < 0.0001 and P = 0.0092 for LPV/r- and EFV-based, respectively) and time to rebound after suppression significantly faster (log-rank P = 0.014 and P = 0.0001 for LPV/r- and EFV-based, respectively). Logistic regression confirmed the worse outcomes in the ABC groups even after adjustment for confounders. Conclusion: Data from this urban pediatric ART service program show significantly poorer virological performance of ABC compared with d4T-based regimens, a signal that urgently warrants further investigation.
2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A

Salvinorin (Sal) A is a naturally occurring, selective κ opioid receptor (KOPR) agonist with a short duration of action in vivo. Pharmacological properties of a C(2) derivative, 2-methoxymethyl (MOM)-Sal B, were characterized. MOM-Sal B bound to KOPR with high selectivity and displayed ∼3-fold higher affinity than U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide methanesulfonate] and Sal A. It acted as a full agonist at KOPR in guanosine 5′-O-(3-[35S]thio)triphosphate binding and was ∼5- and ∼7-fold more potent than U50,488H and Sal A, respectively. In Chinese hamster ovary cells stably expressing KOPR, all three κ agonists internalized or down-regulated KOPR to similar extents, with MOM-Sal B being the most potent. In mice, MOM-Sal B (0.05–1 mg/kg s.c.) caused immediate and dose-dependent immobility lasting ∼3 h, which was blocked by norbinaltorphimine. In contrast, ambulation in a Y-maze was increased when rats received MOM-Sal B (1–5 mg/kg s.c.). In addition, MOM-Sal B (0.5–5 mg/kg i.p.) produced antinociception (hot-plate test) and hypothermia in a dose-dependent manner in rats. MOM-Sal B was more potent than U50,488H in both tests and more efficacious than U50,488H in the hot-plate test. These latter two in vivo effects were blocked by norbinaltorphimine, indicating KOPR-mediated actions. Sal A at 10 mg/kg elicited neither antinociception nor hypothermia 30 min after administration to rats. In summary, MOM-Sal B is a potent and efficacious KOPR agonist with longer lasting in vivo effects than Sal A.
Performance of tense thin film torsion bar for large-rotation and low-voltage driving of micromirror

A micromirror device is developed realizing the large-rotation and the low-voltage driving (obtained maximum value is 8.6 degrees at 5 V). The thin film torsion bars, which consist of SiN and Au/Cr films, contribute to this performance. Inside the torsion bar, the tension is included for generating the compliance in the mirror rotation and stiffness in other movements. The performance of the torsion bar is investigated
Characterization of human PA2.26 antigen (T1α–2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas

We report the full cDNA sequence encoding the human homologue of murine PA2.26 (T1α‐2, podoplanin), a small mucin‐type transmembrane glycoprotein originally identified as a cell‐surface antigen induced in keratinocytes during mouse skin carcinogenesis. The human PA2.26 gene is expressed as 2 transcripts of 0.9 and 2.7 kb in several normal tissues, such as the placenta, skeletal muscle, heart and lung. Using a specific polyclonal antibody raised against a synthetic peptide of the protein ectodomain, PA2.26 was immunohistochemically detected in about 25% (15/61) of human early oral squamous cell carcinomas. PA2.26 distribution in the tumours was heterogeneous and often restricted to the invasive front. Double immunofluorescence and confocal microscopy analysis showed that PA2.26 colocalized with the membrane cytoskeleton linker ezrin at the surface of tumour cells and that its presence in vivo was associated with downregulation of membrane E‐cadherin protein expression. Ectopic expression of human PA2.26 in HeLa carcinoma cells and immortalized HaCaT keratinocytes promoted a redistribution of ezrin to the cell edges, the formation of cell‐surface protrusions and reduced Ca2+‐dependent cell‐cell adhesiveness. These results point to PA2.26 as a novel biomarker for oral squamous cell carcinomas that might be involved in migration/invasion. © 2004 Wiley‐Liss, Inc.
Single Defect in Finite one Dimensional Photonic Crystals

Applying transfer matrix method, we get reflection and transmission coefficient of finite one dimensional photonic crystals. At the same time, we consider the position influence of single defect. We find the frequency of defect mode is same, but the height of transmission peak is not same when single defect is in different position of crystal. The transmission peak is maximum when the defect is in center of finite one dimensional photonic crystals.
A New Tactile Sensor for Robotic Underwater Applications

Please find enclosed our response to your report request of 14 September 1994. The following material is divided into three sections: a brief overview of the scientific progress on our ONR-funded work over the past twelve months, descriptions of two significant accomplishments emerging over the past year, and a standard yearly productivity report. If you have any questions regarding this information, please contact me either by telephone or electronic mail.
Measurements At EPA Of Vacuum And Electron-Cloud Related Effects

In the LHC, in addition to the molecular photodesorption due to synchrotron radiation, an electron cloud will produce a significant gas load due to electron stimulated desorption. This electron cloud build-up is strongly dependant on the primary photoelectrons, secondary electron production and on the reflectivity of photons and electrons. The dependence of these phenomena on surface properties and of vacuum chamber materials is discussed. Experiments performed at cryogenic temperatures with the COLDEX apparatus, installed on an external EPA synchrotron radiation beam line, are presented. Photon irradiations at room temperature have been performed to study in detail the scrubbing effect by photons and electrons and will be used to extrapolate to the condition in the SPS and the LHC vacuum systems. Plans for future experiments with LHC-type beams in the SPS, to be performed at room temperature and at cryogenic temperatures, are presented.
Aging of the Human Vestibular System

Abstract Aging affects every sensory system in the body, including the vestibular system. Although its impact is often difficult to quantify, the deleterious impact of aging on the vestibular system is serious both medically and economically. The deterioration of the vestibular sensory end organs has been known since the 1970s; however, the measurable impact from these anatomical changes remains elusive. Tests of vestibular function either fall short in their ability to quantify such anatomical deterioration, or they are insensitive to the associated physiologic decline and/or central compensatory mechanisms that accompany the vestibular aging process. When compared with healthy younger individuals, a paucity of subtle differences in test results has been reported in the healthy older population, and those differences are often observed only in response to nontraditional and/or more robust stimuli. In addition, the reported differences are often clinically insignificant insomuch that the recorded physiologic responses from the elderly often fall within the wide normative response ranges identified for normal healthy adults. The damaging economic impact of such vestibular sensory decline manifests itself in an exponential increase in geriatric dizziness and a subsequent higher prevalence of injurious falls. An estimated $10 to $20 billion dollar annual cost has been reported to be associated with falls-related injuries and is the sixth leading cause of death in the elderly population, with a 20% mortality rate. With an estimated 115% increase in the geriatric population over 65 years of age by the year 2050, the number of balanced-disordered patients with a declining vestibular system is certain to reach near epidemic proportions. An understanding of the effects of age on the vestibular system is imperative if clinicians are to better manage elderly patients with balance disorders, dizziness, and vestibular disease.
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

A prevailing neuroinflammation hypothesis is that increased production of proinflammatory cytokines contributes to progressive neuropathology, secondary to the primary damage caused by a traumatic brain injury (TBI). In support of the hypothesis, post-injury interventions that inhibit the proinflammatory cytokine surge can attenuate the progressive pathology. However, other post-injury neuroinflammatory responses are key to endogenous recovery responses. Therefore, it is critical that pharmacological attenuation of detrimental or dysregulated neuroinflammatory processes avoid pan-suppression of inflammation. MW151 is a CNS-penetrant, small molecule experimental therapeutic that restores injury- or disease-induced overproduction of proinflammatory cytokines towards homeostasis without immunosuppression. Post-injury administration of MW151 in a closed head injury model of mild TBI suppressed acute cytokine up-regulation and downstream cognitive impairment. Here, we report results from a diffuse brain injury model in mice using midline fluid percussion. Low dose (0.5–5.0 mg/kg) administration of MW151 suppresses interleukin-1 beta (IL-1β) levels in the cortex while sparing reactive microglia and astrocyte responses. To probe molecular mechanisms, we used live cell imaging of the BV-2 microglia cell line to demonstrate that MW151 does not affect proliferation, migration, or phagocytosis of the cells. Our results provide insight into the roles of glial responses to brain injury and indicate the feasibility of using appropriate dosing for selective therapeutic modulation of injurious IL-1β increases while sparing other glial responses to injury.
The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomised study.

BACKGROUND The objective was to evaluate the oedema-protective effect of a vasoactive drug (coumarin/troxerutin [SB-LOT]) plus compression stockings in patients suffering from chronic venous insufficiency after decongestion of the legs as recommended by the new guidelines. PATIENTS AND METHODS 231 patients were randomly assigned medical compression stockings plus SB-LOT (90 mg coumarin and 540 mg troxerutin per day) or medical compression stockings plus placebo for the first 4 weeks and SB-LOT or placebo for the second 12 weeks of the study. The primary efficacy endpoint was the lower leg volume measured by well-established water plethysmometry. RESULTS 226 patients were evaluated. After ceasing compression stockings, an edema protective effect was detected in the SB-LOT-group but not in the controls. Recurrence of leg volume increase was by 6.5 +/- 12.1 ml and by 36.7 +/- 12.1 ml in the SB-LOT and placebo group, respectively (p = 0.0402). The local complaint score and general aspects of quality of life were also superior for the SB-LOT-group (p = 0.0041). Significant differences were also observed with regard to clinical global impression and therapeutic effect. No serious adverse drug reaction or clinically relevant impairment of laboratory parameters occur. CONCLUSION This study confirms the oedema-protective effect of SB-LOT in chronic venous insufficiency and provides a treatment option for patients who discontinue compression after a short time.
Number of hidden states and memory: a joint order estimation problem for Markov chains with Markov regime

This paper deals with order identification for Markov chains with Markov regime (MCMR) in the context of finite alphabets. We define the joint order of a MCMR process in terms of the number k of states of the hidden Markov chain and the memory m of the conditional Markov chain. We study the properties of penalized maximum likelihood estimators for the unknown order (k, m) of an observed MCMR process, relying on information theoretic arguments. The novelty of our work relies in the joint estimation of two structural parameters. Furthermore, the different models in competition are not nested. In an asymptotic framework, we prove that a penalized maximum likelihood estimator is strongly consistent without prior bounds on k and m . We complement our theoretical work with a simulation study of its behaviour. We also study numerically the behaviour of the BIC criterion. A theoretical proof of its consistency seems to us presently out of reach for MCMR, as such a result does not yet exist in the simpler case where m = 0 (that is for hidden Markov models).
Colour As a Signal for Entraining the Mammalian Circadian Clock

Twilight is characterised by changes in both quantity (“irradiance”) and quality (“colour”) of light. Animals use the variation in irradiance to adjust their internal circadian clocks, aligning their behaviour and physiology with the solar cycle. However, it is currently unknown whether changes in colour also contribute to this entrainment process. Using environmental measurements, we show here that mammalian blue–yellow colour discrimination provides a more reliable method of tracking twilight progression than simply measuring irradiance. We next use electrophysiological recordings to demonstrate that neurons in the mouse suprachiasmatic circadian clock display the cone-dependent spectral opponency required to make use of this information. Thus, our data show that some clock neurons are highly sensitive to changes in spectral composition occurring over twilight and that this input dictates their response to changes in irradiance. Finally, using mice housed under photoperiods with simulated dawn/dusk transitions, we confirm that spectral changes occurring during twilight are required for appropriate circadian alignment under natural conditions. Together, these data reveal a new sensory mechanism for telling time of day that would be available to any mammalian species capable of chromatic vision.
Scheduling policies based on dynamic throughput and fairness tradeoff control in LTE-A networks

In LTE-A cellular networks there is a fundamental trade-off between the cell throughput and fairness levels for preselected users which are sharing the same amount of resources at one transmission time interval (TTI). The static parameterization of the Generalized Proportional Fair (GPF) scheduling rule is not able to maintain a satisfactory level of fairness at each TTI when a very dynamic radio environment is considered. The novelty of the current paper aims to find the optimal policy of GPF parameters in order to respect the fairness criterion. From sustainability reasons, the multi-layer perceptron neural network (MLPNN) is used to map at each TTI the continuous and multidimensional scheduler state into a desired GPF parameter. The MLPNN non-linear function is trained TTI-by-TTI based on the interaction between LTE scheduler and the proposed intelligent controller. The interaction is modeled by using the reinforcement learning (RL) principle in which the LTE scheduler behavior is modeled based on the Markov Decision Process (MDP) property. The continuous actor-critic learning automata (CACLA) RL algorithm is proposed to select at each TTI the continuous and optimal GPF parameter for a given MDP problem. The results indicate that CACLA enhances the convergence speed to the optimal fairness condition when compared with other existing methods by minimizing in the same time the number of TTIs when the scheduler is declared unfair.
Contact Avoidance toward People with Stigmatized Attributes: Mate Choice

If contact avoidance is used to avoid harmful people, then this can play an important role when people choose a spouse, by eliminating undesirable people from the list of candidates. The purpose of this study was to reveal the sex difference in contact avoidance toward people with stigmatic attributes, who are therefore disadvantaged as spouse candidates. A total of 228 university students (101 men, 127 women) participated in the survey. Seven types of men and women with stigmatic characteristics were presented and the respondents asked how much they wanted to avoid contact with each type of person in eight physical contact situations. Female respondents wanted to avoid contact with stigmatized men more than with stigmatized women. On the other hand, male respondents showed comparable responses to both stigmatized men and women. The results were considered from the perspective of mate selection based on evolutionary psychology.
Synthesizing third normal form relations from functional dependencies

It has been proposed that the description of a relational database can be formulated as a set of functional relationships among database attributes. These functional relationships can then be used to synthesize algorithmically a relational scheme. It is the purpose of this paper to present an effective procedure for performing such a synthesis. The schema that results from this procedure is proved to be in Codd's third normal form and to contain the fewest possible number of relations. Problems with earlier attempts to construct such a procedure are also discussed.
Large-scale power in the CMB and new physics: An analysis using Bayesian model comparison

One of the most tantalizing results from the Wilkinson Microwave Anisotropy Probe ~WMAP! experiment is the suggestion that the power at large scales is anomalously low when compared to the prediction of the ‘‘standard’’ L cold dark matter ~CDM! model. The same anomaly, although with somewhat larger uncertainty, was also previously noted in the COBE data. In this work we discuss possible alternate models that give better fits on large scales and apply a model-comparison technique to select amongst them. We find that models with a cutoff in the power spectrum at large scales are indeed preferred by data, but only by a factor of 3.6, at most, in the likelihood ratio, corresponding to about ‘‘1.6 s’’ if interpreted in the traditional manner. Using the same technique, we have also examined the possibility of a systematic error in the measurement or prediction of the large-scale power. Ignoring other evidence that the large-scale modes are properly measured and predicted, we find this possibility somewhat more likely, with roughly a 2.75s evidence.