Miracle-dz/UniFAR-FTUs huggingface dataset:
Quo vadis, IT education?

Human society is rapidly growing into knowledge society, which is based on all-increasing use of Information Technology (IT). Rapid development of IT technology has posed before the IT-education several challenges: rapid, all-increasing flood of new information (half of this what IT student learns in his/her first year of study is already obsolete after three years, and estimates show that we are only in the middle of the information revolution), very heterogeneous population of students - different ages, from different countries, from EU and from Far East, who nearly all are already working (full-time), thus having very different background knowledge, who record lectures (if they are present) with their iPhone/iPad images and videos, who communicate with their mentors sending links to video clips in YouTube; changing nature of Universities, which are transforming into commercial enterprises (based on profit) and are forced to act correspondingly. The whole value of higher IT education is sometimes questioned - Bill Gates and Steve Jobbs both dropped out from college and many employers believe school-leavers make better workers than university graduates [1]. In the paper are discussed current developments in society and IT, challenges of IT education and considered changes what the IT education is currently having in our countries in the general context of EU efforts for promoting e-Skills and lifelong learning.
Relieving Autophagy and 4EBP1 from Rapamycin Resistance

ABSTRACT The mammalian target of rapamycin complex 1 (mTORC1) is a multiprotein signaling complex regulated by oncogenes and tumor suppressors. Outputs downstream of mTORC1 include ribosomal protein S6 kinase 1 (S6K1), eukaryotic translation initiation factor 4E (eIF4E), and autophagy, and their modulation leads to changes in cell growth, proliferation, and metabolism. Rapamycin, an allosteric mTORC1 inhibitor, does not antagonize equally these outputs, but the reason for this is unknown. Here, we show that the ability of rapamycin to activate autophagy in different cell lines correlates with mTORC1 stability. Rapamycin exposure destabilizes mTORC1, but in cell lines where autophagy is drug insensitive, higher levels of mTOR-bound raptor are detected than in cells where rapamycin stimulates autophagy. Using small interfering RNA (siRNA), we find that knockdown of raptor relieves autophagy and the eIF4E effector pathway from rapamycin resistance. Importantly, nonefficacious concentrations of an ATP-competitive mTOR inhibitor can be combined with rapamycin to synergistically inhibit mTORC1 and activate autophagy but leave mTORC2 signaling intact. These data suggest that partial inhibition of mTORC1 by rapamycin can be overcome using combination strategies and offer a therapeutic avenue to achieve complete and selective inhibition of mTORC1.
Williamson on knowledge

Introduction 1. E = K and Perceptual Knowledge 2. Can the Concept of Knowledge be Analysed? 3. Is Knowing a State of Mind? The Case Against 4. The Knowledge Account of Assertion and the Nature of Testimonial Knowledge 5. Williamson on Knowledge and Evidence 6. Knowledge and Objective Chance 7. Primeness, Internalism, Explanation 8. Williamson's Casual Approach to Probabilism 9. Assertion, Knowledge and Lotteries 10. Defeating the Dogma of Defeasibility 11. Evidence = Knowledge: Williamson's Solution to Skepticism 12. Timothy Williamson's Knowledge and its Limits 13. Are Mental States Luminous? 14. Cognitive Phenomenology, Semantic Qualia and Luminous Knowledge 15. Aristotle's Condition 16. Reponses to Critics
Selective blockade by nifedipine of ‘purinergic’ rather than adrenergic nerve‐mediated vasopressor responses in the pithed rat

1 Nifedipine can attenuate pressor responses to sympathetic nerve stimulation both in the presence and in the absence of α‐adrenoceptor blocking agents. 2 In the presence of α,β‐methylene ATP, nifedipine produces only a small attenuation of the vasopressor response. 3 Nifedipine attenuates the vasopressor response produced by intravenous bolus administration of α,β‐methylene ATP. 4 The results suggest that the purinergic component of the vasopressor response to stimulation of the sympathetic outflow in the rat is subject to blockade by nifedipine, whereas the α‐adrenoceptor‐mediated response to co‐transmitter noradrenaline is relatively resistant.
Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

The SCFFBW7 ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting to create isoform-specific Fbw7-null mutations in human cells and found that the nucleoplasmic Fbw7α isoform accounts for almost all Fbw7 activity toward cyclin E, c-Myc, and sterol regulatory element binding protein 1. Cyclin E sensitivity to Fbw7 varies during the cell cycle, and this correlates with changes in cyclin E–cyclin-dependent kinase 2 (CDK2)–specific activity, cyclin E autophosphorylation, and CDK2 inhibitory phosphorylation. These data suggest that oscillations in cyclin E–CDK2-specific activity during the cell cycle regulate the timing of cyclin E degradation. Moreover, they highlight the utility of adeno-associated virus–mediated gene targeting in functional analyses of complex loci.
Simultaneous inversion for pre-stack seismic data based on Markov random field

Pre-stack seismic inversion has inherently supremacy and is a complicated problem. It is a simultaneous inversion for multi-parameters and is ill-posed and band-limited. Thus the results are of non-unique and its process is unstable. Combining the full Zoeppritz equation with both section constant VS/VP and the edge-preserving regularization can relieve these problems. Here we provided an inverted strategy constructing a new objective function based on the edge-preserving regularization and Markov random field (MRF). The method needs to gain reflectivity by the full Zoeppritz equation, and applies fast simulated annealing (FSA) to nonlinear optimization problem. Combining high- with low- orders MRF can improve the inverted results, namely utilize high-order MRF at the early stage and low-order MRF at late iterations. Moreover, to the transverse isotropy layered model, a large coefficient in horizontal direction is helpful to improve lateral continuity, and a small coefficient in vertical direction can preserve large longitudinal gradient. We test the method on field data example. The inverted results of multiple-order MRF are better than that of single-order MRF, and they match well with logging data.
Telomere dynamics in free-living edible dormice (Glis glis): the impact of hibernation and food supply

ABSTRACT We studied the impact of hibernation and food supply on relative telomere length (RTL), an indicator for aging and somatic maintenance, in free-living edible dormice. Small hibernators such as dormice have ∼50% higher maximum longevity than non-hibernators. Increased longevity could theoretically be due to prolonged torpor directly slowing cellular damage and RTL shortening. However, although mitosis is arrested in mammals at low body temperatures, recent evidence points to accelerated RTL shortening during periodic re-warming (arousal) from torpor. Therefore, we hypothesized that these arousals during hibernation should have a negative effect on RTL. Here, we show that RTL was shortened in all animals over the course of ∼1 year, during which dormice hibernated for 7.5–11.4 months. The rate of periodic arousals, rather than the time spent euthermic during the hibernation season, was the best predictor of RTL shortening. This finding points to negative effects on RTL of the transition from low torpor to high euthermic body temperature and metabolic rate during arousals, possibly because of increased oxidative stress. The animals were, however, able to elongate their telomeres during the active season, when food availability was increased by supplemental feeding in a year of low natural food abundance. We conclude that in addition to their energetic costs, periodic arousals also lead to accelerated cellular damage in terms of RTL shortening. Although dormice are able to counteract and even over-compensate for the negative effects of hibernation, restoration of RTL appears to be energetically costly. Highlighted Article: Telomeres in edible dormice shorten over the hibernation season, but these long-lived rodents are able to fully restore telomeres during summer if food supply is sufficient.
n-dimensional Harmonic Balance Method extended to non-explicit nonlinearities

The harmonic balance method is widely used for the analysis of strongly nonlinear problems under periodic excitation. The concept of hypertime allows for the generalization of the usual formulation to multi-tone excitations. In this article, the method is applied to a system involving a nonlinearity which cannot be explicitly expressed in the multi-frequency domain in terms of harmonic coef_cients. The direct and inverse Discrete Fast Fourier Transforms are then necessary to alternate between time and frequency domains in order to take into account this nonlinearity. The results show the efficiency and the precision of the method.
Suicidal Behavior Among Elementary School Students and Current Needs in Prevention Practices: A Survey of Virginia School Counselors

Most of the research on suicidal behavior has focused on the middle and high school level, and an extensive review of the literature shows that more information is needed on the current needs and prevention practices at the elementary school level. In Virginia, school psychologists rated school counselors the top professional in elementary schools to lead suicide intervention and prevention efforts. Due to this, the current study examined 161 Virginia school counselors’ responses to an online survey to further explore intervention and prevention efforts among school professionals. Both school counselors and school psychologists noted that receiving additional training and having established crisis plans are important in regards to suicidal behavior. While both professionals agree that suicide at the elementary level is something that should be taken seriously, the results found that open communication and discussion among professionals is an area that could be improved.
Late-onset systemic lupus erythematosus in Northwestern Spain: differences with early-onset systemic lupus erythematosus and literature review

To further investigate into the epidaemiology of systemic lupus erythematosus (SLE) in Southern Europe, we have assessed the incidence, clinical spectrum and survival of patients diagnosed with late-onset SLE (age ≥ 50 years) according to the 1982 American College of Rheumatology (ACR) classification criteria at the single hospital for a well-defined population of Lugo, Northwestern (NW) Spain. Between January 1987 and December 2006, 51 (39.3%) of the 150 patients diagnosed as having SLE fulfilled definitions for late-onset SLE. The predominance of women among late-onset SLE (4:1) was reduced when compared with that observed in early-onset SLE (7:1). However, the incidence of late-onset SLE was significantly higher in women (4.2 [95% confidence interval (CI): 3.1–5.6] per 100,000 population) than in men (1.3 [95% CI: 0.6–2.2] per 100,000 population) (p < 0.001). As observed in early-onset SLE, the most frequent clinical manifestation in patients with late-onset SLE was arthritis (71.2%). Renal disease was less common in late-onset SLE (13.5%) than in early-onset SLE (26.4%); p = 0.07). In contrast, secondary Sjögren syndrome was more commonly found in the older age-group (27.1% versus 12.1%; p = 0.03). A non-significantly increased incidence of serositis was also observed in late-onset SLE patients (33.9% versus 22.0%; p = 0.13). Hypocomplementaemia (72.9% versus 91.2%) and positive results for anti-DNA and anti-Sm (49.2% and 6.8% versus 68.1% and 23.1, respectively) were significantly less common in late-onset SLE patients than in early-onset SLE. The probability of survival was reduced in late-onset SLE (p < 0.001). With respect to this, the 10-year and 15-year survival probability were 74.9 % and 63.3% in the late-onset SLE group and 96.3% and 91.0% in patients with early-onset SLE, respectively. In conclusion, our results confirm that in NW Spain SLE is not uncommon in individuals 50 years and older. In keeping with earlier studies, late-onset SLE patients from NW Spain have some clinical and laboratory differences with respect to those individuals with early-onset SLE. Our data support the claim of a reduced probability of survival in the older age-group of SLE patients.
Blood Flow Restricted Exercise and Vascular Function

It is established that regular aerobic training improves vascular function, for example, endothelium-dependent vasodilatation and arterial stiffness or compliance and thereby constitutes a preventative measure against cardiovascular disease. In contrast, high-intensity resistance training impairs vascular function, while the influence of moderate-intensity resistance training on vascular function is still controversial. However, aerobic training is insufficient to inhibit loss in muscular strength with advancing age; thus, resistance training is recommended to prevent sarcopenia. Recently, several lines of study have provided compelling data showing that exercise and training with blood flow restriction (BFR) leads to muscle hypertrophy and strength increase. As such, BFR training might be a novel means of overcoming the contradiction between aerobic and high-intensity resistance training. Although it is not enough evidence to obtain consensus about impact of BFR training on vascular function, available evidences suggested that BFR training did not change coagulation factors and arterial compliance though with inconsistence results in endothelial function. This paper is a review of the literature on the impact of BFR exercise and training on vascular function, such as endothelial function, arterial compliance, or other potential factors in comparison with those of aerobic and resistance training.
A Measurement Study on the Benefits of Open Routers for Overlay Routing

As the rapid proliferation of multimedia communications has been significantly challenging the Internet on providing a high-quality transporting service to achieve desirable audio and video user experience, overlay routing is proposed as a practical technique to complement some inherent deficiencies of the current IP routing service. While many research and realistic systems have proven the effectiveness of overlay routing on improving end-to-end (E2E) performance, this paper performs a measurement study on the potential benefits of open router s, a novel promising technical concept emerging recently, to boost overlay routing for multimedia communications. Based on analysis of a large amount of measurements collected between more than 200 PlanetLab sites over the world, our results show that when being deployed appropriately, even a small number of open routers will be able to remarkably enhance overlay routing’s ability of improving E2E performance for multimedia communications. Accordingly, several practical heuristics for selecting suitable places to deploy open routers are proposed and comparatively evaluated based on real Internet topological and routing data.
The Computation of Fieldwork Achievement in Occupational Therapy Degrees: Measuring a Minefield?

Fieldwork is a distinct element of undergraduate occupational therapy degrees. Students are seconded from educational institutions to fieldwork educators in practice settings, where their vocational competence is developed and assessed. Fieldwork procedures are devised by individual educational institutions. This paper reports the findings of a survey based on data from fieldwork coordinators, which investigated the incidence of and reasoning behind the computation of fieldwork achievement in England and Ireland. The results showed that every programme had considered computing fieldwork performance at some time and that most were actually doing this. Many programmes that were not computing fieldwork performance expressed the desire to do so, but were uncertain about this action. Highly inconsistent practice was found regarding fieldwork assessment procedures and the weightings given to fieldwork elements; consequently, students' practical fieldwork skills may not be conveyed by their degree classification award. Various factors influenced fieldwork computation, with many inconsistencies and contradictions emerging. The study concluded that computation of students' fieldwork achievement was highly inconsistent. Further development is vital to improve this situation for students, educators, clinicians and employers alike. It is suggested that development be coordinated at a national level.
Latitudinal and altitudinal variation of bud burst in western populations of sessile oak (Quercus petraea (Matt) Liebl)

Le comportement du debourrement des bourgeons au printemps a ete etudie dans un reseau de comparaison de provenances de chene sessile sur 50 populations. Des variations importantes dans le comportement phenologique entre les populations ont ete mises en evidence et elles ont pu etre reliees a la latitude et l'altitude ainsi qu'a la tolerance au froid. Les populations tardives sont nordiques ou d'altitude faible. Ces meme populations sont plus resistantes aux gelees printanieres tardives. Du fait de la structuration geographique observee et de sa liaison avec des caracteres adaptatifs, il est conseille aux forestiers d'utiliser des origines locales pour les reboisements artificiels de chene sessile.
Stability Analysis of Polynomial-Fuzzy-Model-Based Control Systems Using Switching Polynomial Lyapunov Function

This paper investigates the stability problem of polynomial-fuzzy-model-based control system, which is formed by a polynomial fuzzy model and a polynomial fuzzy controller connected in a closed loop. A switching polynomial Lyapunov function consisting of a number of local polynomial Lyapunov functions is proposed to investigate the system stability. It demonstrates a nice property in favor of the stability analysis that each local polynomial Lyapunov function transits continuously to each other. As different local polynomial Lyapunov functions are employed to investigate the system stability according to the operating domain, relaxed stability conditions compared with the stability analysis result with a common Lyapunov function can be developed. In order to allow a greater design flexibility for the polynomial fuzzy controller, the proposed polynomial-fuzzy-model-based control scheme does not require that both the polynomial fuzzy model and polynomial fuzzy controller share the same premise membership functions. Stability conditions in terms of sum of squares are obtained to guarantee system stability and facilitate control synthesis. Simulation examples are given to verify the stability analysis results and demonstrate the effectiveness of the proposed polynomial fuzzy control scheme.
Comparação entre comportamentos apresentados por mães de pré-escolares clínicos e não clínicos em uma situação lúdica

To analyze interaction patterns that mothers have with their children with no behavioral problems might allow the evaluation of parent skills training programs, If the taught skills are the same that non-clinical children parents use in their daily life management. The objective of this study was to verify the existence of differences in the response of mothers with clinical and non-clinical preschool children in a playing semi-structured interaction. Frequency of emission of generic and descriptive praise, criticism and orders by the mother, and obedience, and non compliance by the child were measured and compared. The mothers on non-clinical children made less use of criticism behavior when compared with mothers of the clinical children. Praise and orders did not differ in the two groups. Children differ only in the non-compliance behavior. To teach mothers of clinical children to not punish inappropriate behaviors, may be as important to the clinical improvement than to teach them to praise appropriate behaviors.
Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.
An exploratory study into the public and situated visualisation of local data in urban communities

While data visualisations are being used increasingly often in news reports, mobile applications and the like, visualisations designed specifically for public settings are still largely uninvestigated. My thesis is an exploratory study, looking into the role public and situated visualisations can play in revealing local data to urban communities - and how such visualisations can connect the members of these communities.
Effects of Environmental Endocrine Disruptors on Pubertal Development

The onset and course of puberty are under the control of the neuroendocrine system. Factors affecting the timing and regulation of the functions of this system may alter the onset and course of puberty. Several environmental endocrine disruptors (EDs) with significant influences on the normal course of puberty have been identified. Numerous animal and human studies concerning EDs have been conducted showing that these substances may extensively affect human health; nevertheless, there are still several issues that remain to be clarified. In this paper, the available evidence from animal and human studies on the effects of environmental EDs with the potential to cause precocious or delayed puberty was reviewed. Conflict of interest:None declared.
Prevalencia y tipos de maltrato en el noviazgo en adolescentes y adultos jóvenes

General and sex-differences in prevalence were examined with regard to physical, psychological, emotional, sexual, economical, and negligent dating violence behaviors, in 902 adolescents and youths Colombian single adults, 417 males and 485 women, 15-35 years years-old. 85.6% informed to have been object, at least once, of some abusive behavior. Not statistical differences by sex were found in this general prevalence. The more frequent maltreatment type was the psychological, continued by physical, emotional, sexual, economical, and negligent. Males informed more frequently some emotional, sexual, economical, and negligent abusive behavior than women. Not statistical differences by sex were found with regard to the physical and psychological abuse.