Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of extracellular matrix in tumor invasion: migration of glioma cells along fibronectin-positive mesenchymal cell processes.

OBJECTIVE The major morbidity of glioma lies in its infiltrative growth. One of the major patterns of this invasive growth is the formation of Scherer's secondary structures associated with the blood vessels and the leptomeninges. To better understand the role of extracellular matrix (ECM) in glioma invasion, we investigated in vitro the interaction between glioma cells and the meningeal mesenchymal tissue from the brain. As an aid to this study, ECM in glioma cell line spheroids was compared with that in primary fetal brain aggregates. METHODS To study the expression of ECM, four glioma cell lines (U-87 MG, U-251 MG, AN1/lac-z, and HF-66) and primary cells from fetal rat brain were grown as spheroids and monolayers. To sudy the role of ECM in glioma invasion, spheroids from the glioma cell lines were grown over established cultures of fetal meningeal and mesenchymal tissue. Expression of fibronectin, laminin, tenascin, collagen VI, and chondroitin sulfate proteoglycan was studied by immunofluorescence. RESULTS Expression of ECM by the spheroids was variable. U-87 MG expressed most of the ECM components robustly, whereas AN1/lac-z expressed them all weakly. Fetal rat brain aggregates produced minimal ECM. In cocultures of glioma spheroids and fetal meningeal mesenchymal tissue, individual cells from the glioma spheroids that expressed least fibronectin (AN1/lac-z and U-251 MG) migrated along the fibronectin-positive mesenchymal cells in the culture dish. Cells from the other two lines (U-87 MG and HF-66) that expressed fibronectin strongly did not demonstrate such behavior. None of the other ECM components showed a similar association; mesenchymal cells did not express laminin as strongly as fibronectin, and glioma cells were not observed to align with the laminin-positive structures. CONCLUSION This study suggests that fibronectin may play a key role in intracerebral invasion of glioma cells.
Precision delay matching testing for gate driver ICs on IFLEX™ tester platform

Green energy sources such as solar power, wind, and biomass . are getting more attention especially after the nuclear crisis caused by earthquake in Mar. 2011 in Japan. The solar power has been considered to be the major contributor of the green energy. There are more than enough solar irradiations available to satisfy the world's energy demands. However the traditional photovoltaic (PV) systems suffer from various power losses, the performance shows average losses of about 20%-30% in electricity production. Some companies provide advance system architectures which can boost solar panel output power by up to 20%-25%. One of a key element of the system is the DC-DC converter [1]. Texas Instruments' high voltage gate driver ICs (HVIC) can be used as a DC-DC converter, half/full bridge applications or class-D audio amplifiers. There are challenges for the HVIC testing. First, the timing measurements for propagation delay matching in both buck and boost which need to be in nanoseconds range but the typical production automatic test equipment (ATE) specification of timing measurement unit (TMU) accuracy is approximate 2 nanoseconds (ns) and meanwhile, the output voltage of gate driver application can exceed 100 volts. Second, test time and multi-site testing have to be considered. In this paper, we have discussed the critical timing measurements and have successfully implemented the multi-site delay matching testing on IFLEXTM ATE platform with 100 picoseconds (ps) resolution while the boost is operating at 120V.
Presenteeism in Workplace: Constructing a Cross-cultural Framework

In the current climate of global economic depression, presenteeism, the opposite of absenteeism, is becoming more prevalent in the workplace. Although some definitional confusion persists, the most recent scholarly conception of presenteeism involves showing up for work when one is ill. The purpose of this paper is to review the presenteeism literature and to trace the latest development of presenteeism research. Based on existing empirical research from different disciplines, such as medical, nursing and health psychology fields, we delineated antecedents and consequences of presenteeism. We also identified some challenges and limitations in this research area, including confusions in definition, lack of reliable scales and adequate theoretical frameworks. Finally, we proposed several directions for future research, including integrating different theoretical perspectives and research methodologies. Moreover, we focused on the future directions for research on presenteeism in Taiwan to delineate its cultural relevance. It is hoped that the continuous interaction between the management practice and theoretical development of research on presenteeism would help to build a healthy work environment.
PSIHOLOŠKA PRILAGODBA RODITELJA NA DIJETE S KRONIČNOM BOLESTI

Cilj je ovog istraživanja ispitati razlikuju li se majke i očevi zdrave djece i majke i očevi djece s cerebralnom paralizom u faktorima Wallanderova i Varnijeva (1998.) modela prilagodbe na kroničnu bolest djeteta. U ispitivanje su bile uključene dvije skupine sudionika. Kliničku skupinu činili su roditelji 77 djece predškolske i školske dobi s cerebralnom paralizom (59 bračnih parova te 18 roditelja bez bračnoga partnera). Usporednu skupinu činili su roditelji 108 zdrave djece (90 bračnih parova i 18 roditelja bez bračnoga partnera). Primijenjen je niz mjernih instrumenata kojima su se nastojale obuhvatiti relevantne varijable koje po modelu ulaze u rizične i zaštitne faktore te prilagodbu. Dobiveni rezultati pokazuju da majke djece s cerebralnom paralizom u usporedbi s majkama zdrave djece doživljavaju veći intenzitet stresa u roditeljskoj ulozi (rizičan faktor), imaju izraženiji neuroticizam, percipiraju manju kvalitetu braka i obiteljsku kohezivnost i prilagodljivost, imaju manju dostupnu socijalnu mrežu i veću potrebu za podrškom te u većoj mjeri pribjegavaju suočavanju izbjegavanjem (zaštitni faktori). One pokazuju i izraženije psihičke simptome u usporedbi s majkama zdrave djece (prilagodba). Očevi djece s cerebralnom paralizom u usporedbi s očevima zdrave djece doživljavaju veći intenzitet stresa u roditeljskoj ulozi (rizičan faktor), imaju manje izraženu ekstraverziju i veću potrebu za podrškom (zaštitni faktor) te izraženije psihičke simptome (prilagodba).
Modelling nematode life cycles using dynamic energy budgets

1. To understand the life cycle of an organism, it is important to understand the underlying physiological mechanisms of their life histories. We here use the theory of dynamic energy budgets (DEB) to investigate the close relationships between growth, reproduction and respiration in nematodes. 2. Using a set of simplified equations based on DEB theory, we are able to accurately describe life-cycle data from the literature for the free-living bacterivorous nematodes Caenorhabditis elegans, C. briggsae and Acrobeloides nanus, under different temperature or food regimes. 3. Nematodes apparently differ from other animals, as the initial growth is slower than expected. We explain this phenomenon by food limitation in the larvae, which is supported by more detailed physiological studies. 4. Food density and temperature are shown to have predictable effects on the growth curves (temperature affects only growth rate, whereas food density also affects ultimate size), although the reproduction patterns reveal some deviations from model predictions. 5. The presented model integrates the different aspects of the life cycle into a single framework, and can be applied as such to interpret the effects of various stressors
Nuclear-encoded factors associated with the chloroplast transcription machinery of higher plants

Plastid transcription is crucial for plant growth and development. There exist two types of RNA polymerases in plastids: a nuclear-encoded RNA polymerase (NEP) and plastid-encoded RNA polymerase (PEP). PEP is the major RNA polymerase activity in chloroplast. Its core subunits are encoded by the plastid genome, and these are embedded into a larger complex of nuclear-encoded subunits. Biochemical and genetics analysis identified at least 12 proteins are tightly associated with the core subunit, while about 34 further proteins are associated more loosely generating larger complexes such as the transcriptionally active chromosome (TAC) or a part of the nucleoid. Domain analyses and functional investigations suggested that these nuclear-encoded factors may form several functional modules that mediate regulation of plastid gene expression by light, redox, phosphorylation, and heat stress. Genetic analyses also identified that some nuclear-encoded proteins in the chloroplast that are important for plastid gene expression, although a physical association with the transcriptional machinery is not observed. This covers several PPR proteins including CLB19, PDM1/SEL1, OTP70, and YS1 which are involved in the processing of transcripts for PEP core subunit as well as AtECB2, Prin2, SVR4-Like, and NARA5 that are also important for plastid gene expression, although their functions are unclear.
Research Issues in Knowledge-Based Configuration

Knowledge-based configuration systems have made their way into industrial practice. Nowadays, all major vendors of configuration systems rely on some form of declarative knowledge representation and intelligent search techniques for solving the core configuration problem, due to the inherent advantages of that technology: On the one hand, changes in the business logic (configuration rules) can be accomplished more easily because of the declarative and modular nature of the knowledge bases, while on the other hand highly-optimized, domain-independent problem-solving algorithms are available for the task of constructing valid configurations.Still, the development has not come to an end as, in a world that becomes increasingly automated and wired together, constantly new challenges for the development of intelligent configuration systems come in: Web-based configurators are being made available for large heterogeneous user groups, the provision of mass-customized products requires the integration of INFORMATION SCIENCE PUBLISHING ITB14611
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature

Primary vulvar adenocarcinomas are very rare. We describe the rare case of primary vulvar apocrine adenocarcinoma, a histologically rare subtype of vulvar adenocarcinoma. A 57-year-old Japanese woman presented with an enlarging vulvar mass. A dark-red, hemorrhagic, ulcerated tumor was on the right side of the anterior labial commissure measuring approximately 3.5 × 3.5 cm. Preoperative biopsy showed poorly differentiated carcinoma with partial differentiation to adenocarcinoma. Systemic examination revealed lymph node metastases in both inguinal regions and no other primary source. We performed radical vulvectomy and bilateral inguinal and pelvic lymphadenectomy. Histopathologic diagnosis was apocrine adenocarcinoma of the vulva with inguinal lymph node metastases, pT1bN2bM0. Surgical margins were negative. The patient received no adjuvant chemotherapy or radiation. Inguinal lymph node recurrence occurred after six months. Reresection and adjuvant tomotherapy were performed. After a further 12 months of observation, no rerecurrence was observed. The patient is now on follow-up.
Ionic Mechanisms of Electrotonic Inhibition and Concealed Conduction in Rabbit Atrioventricular Nodal Myocytes

BackgroundThe term “concealed conduction” is used in electrocardiography when a proximal (atrial or ventricular) impulse penetrates the atrioventricular (AV) node but fails to traverse it completely. Its penetration into the node is inferred by its aftereffects on the propagation of succeeding impulses. Concealed AV nodal conduction is a well-established phenomenon, but its precise cellular and subcellular mechanisms are unknown. It has been suggested that concealed conduction results from a transient impairment of excitability caused by the subthreshold depolarization (ie, electrotonic inhibition) that is elicited downstream of the site of block.Methods and Resuls. We studied the ionic mechanism of electrotonic inhibition and concealed conduction in single myocytes isolated from the rabbit AV node. Cells were paced using just-threshold current pulses delivered at a constant (basic) cycle length of 1 second. Appropriately timed interpolation of a conditioning pulse of depolarizing but subthreshold current led to failure of the subsequent, previously successful activation. The ability of the subthreshold response to inhibit subsequent excitation was increased when the interval between the conditioning and succeeding pulses was shortened, when the amplitude of the conditioning pulse was increased, or when the inward sodium current was blocked by superfusion with tetrodotoxin (30 FaM). Voltage clamp analysis demonstrated that electrotonic inhibition results from partial inactivation of the transient calcium current (I.T). Similar results were obtained using a mathematical model (Hodgkin-Huxley type) of the AV nodal myocyte. Additional simulations in a linear array ofAV nodal cells showed that when a premature impulse fails to traverse the AV node, the subthreshold depolarization elicited downstream of the site of block may lead to a transient reduction of excitability with consequent delay or block of the succeeding impulse. ConclusionsThe overall data strongly suggest that some of the electrocardiographic manifestations of concealed AV conduction are the result of electrotonic inhibition of excitability secondary to a transient decrease in Ic'T.
Optimization of culture condition of Habrotrocha sp. by using response surface method

One practical method to increase the density of Habrotrocha sp. , which is a kind of useful bdelloid rotifer in the wastewater biological treatment system, is to cultivate the metazoa in certain numbers and then put it into the treatment system. Therefore, it is necessary to develop a method which can efficiently cultivate Habrotrocha sp‥ In this paper, the optimization of culture condition for Habrotrocha sp. including food dosage, temperature, salinity and pH was investigated by using response surface method. Flour was used as the food of Habrotrocha sp. based on our previous work. The results showed the optimum food particle concentration, temperature, salinity and pH value for culturing Habrotrocha sp. were 7.6×106 particals/mL, 28.2°C, 187mg/L and 6.3, respectively. The actual population of Habrotrocha sp. cultured under the optimized culture condition was 184.0 ind/mL, which is almost the same as the result predicted by response surface method.
Statistical analysis of S-box in image encryption applications based on majority logic criterion

The S-box is used in various block ciphers and the complexity of encryption essentially depends on the strength of S-box. The strength of an S-box can be measured by analyzing its statistical and algebraic properties. The S-box is the only non-linear component in various block ciphers capable of creating confusion. Many S-boxes have been proposed with similar algebraic and statistical properties. Therefore, it is sometimes difficult to choose an S-box for a particular application. The performances of these S-boxes vary and depend on the nature of data and their application. In this paper, we propose a criterion to analyze the prevailing S-boxes and study their strengths and weaknesses in order to determine their suitability in image encryption applications. The proposed criterion uses the results from correlation analysis, entropy analysis, contrast analysis, homogeneity analysis, energy analysis, and mean of absolute deviation analysis. These analyses are applied to advanced encryption standard (AES), affine-power-affine (APA), gray, Lui J, residue prime, S 8 AES, SKIPJACK, and Xyi Sboxes. The results of these analyses are further examined and a majority logic criterion is used to determine the appropriateness of an S-box to image encryption applications.
Prefetching and clustering techniques for network based storage

The usage of network-based applications is increasing, as network speeds increase, and the use of streaming applications, e.g BBC iPlayer, YouTube etc., running over network infrastructure is becoming commonplace. These applications access data sequentially. However, as processor speeds and the amount of memory available increase, the rate at which streaming applications access data is now faster than the rate at which the blocks can be fetched consecutively from network storage. In addition to sequential access, the system also needs to promptly satisfy demand misses in order for applications to continue their execution. This thesis proposes a design to provide Quality-Of-Service (QoS) for streaming applications (sequential accesses) and demand misses, such that, streaming applications can run without jitter (once they are started) and demand misses can be satisfied in reasonable time using network storage. To implement the proposed design in real time, the thesis presents an analytical model to estimate the average time taken to service a demand miss. Further, it defines and explores the operational space where the proposed QoS could be provided. Using database techniques, this region is then encapsulated into an autonomous algorithm which is verified using simulation. Finally, a prototype Experimental File System (EFS) is designed and implemented to test the algorithm on a real test-bed.
Chavez v Martinez's Constitutional Division of Labor

Somewhere in the midst of overruling Bowers v Hardwick1 and allowing educational affirmative action,2 the Court last Term also managed to reconceptualize the Fifth Amendment's privilege against compelled self-incrimination. Chavez v Martinez3 posed what turned out to be a rather significant question: whether, in the context of a custodial interrogation, ? 1983 damages for a violation of the privilege against compelled self-incrimination are available after an incriminating statement has been compelled, but before any attempt has been made to use testimony thus obtained at trial. The Court held that the privilege protects against only the use of compelled incriminating statements against the witness at a criminal trial, not the act of compulsion itself.
Disability and sex work: developing affinities through decriminalization

Abstract This article argues that strong policy frameworks are required to support the health and well-being of sex workers, disabled people, and disabled sex workers. Through an examination of the context of sex work in Canada, we articulate the flaws of sex work criminalization and the persistent barriers that criminalization creates. Our analysis of the intersection of disabled sexuality and access to sexual services identifies how the sex industry can aid in the flourishing of the erotic lives of disabled people. The article culminates in a discussion of the benefits of sex work decriminalization for sex workers, disabled people, and disabled sex workers.
Comprehensive Evaluation of E-commerce Websites Based on PCA and SVM

With the increasing use of e-commerce Web sites, it is gaining more and more attention. The evaluation of e-commerce Web sites becoming the focus of study. This paper design a comprehensive evaluation indicator system. Adopting principal component analysis method to simplify the indicator system. A evaluation model of customer relationship management system based on support vector machine was presented. Using the idea of decision binary tree, then makes the cut date to be the input information of classifier, and establish multi-classification model. By using the combination of the two methods, we will acquire a more objective and believable evaluation result. The simulation result shows that the model has better accuracy of the classification.
Evidence for penetration of diphtheria toxin to the cytosol through a prelysosomal membrane

To kill mammalian cells, diphtheria toxin must be endocytosed and encounter a low pH within intracellular vesicles. The low pH initiates penetration of the catalytically active A fragment of the toxin through a membrane and into the cytosol where the A fragment arrests protein synthesis. To investigate whether penetration occurred through a prelysosomal or a lysosomal membrane, we studied the effect of low temperature on the entry of the toxin into the cytosolic and lysosomal compartments. The toxin arrested protein synthesis at 15 degrees C, indicating entry into the cytosol; however, access to lysosomes was apparently blocked at 15 degrees C, suggesting that the toxin had encountered a low pH before reaching lysosomes and had penetrated a prelysosomal membrane. To further investigate the possibility of prelysosomal acidification, we measured the time required for the toxin to encounter a low pH after endocytosis. Acidification occurred within 3 to 4 min after the toxin was internalized into vesicles. This interval is consistent with prelysosomal acidification since the entry of endocytosed ligands into secondary lysosomes usually takes more than 3 to 4 min.
A Novel Coordinate Transformation-Based Texture Mapping Algorithm

Because the development of medical imaging equipment such as CT and MRI, the data for visualization which be processed continue increasing. In order to meet the demand of the large volume data of real-time processing, a novel technique for texture- based volume rending is discussed in this paper, which based on coordinate transformation and programming graphics processing unit. The algorithm makes full use of the parallel processing of graphics hardware and reduces the transmission of data between CPU and GPU, improves the speed of texture mapping algorithm. The experiments show that the proposed algorithm can improve the frame rate up to 10%-15%.
A Phase Shift Control Strategy For Bidirectional Power Flow In Capacitive Wireless Power Transfer System Using LCLC Compensation

The growing demand of electric vehicles pushes the need of development in the charging systems. This paper discuss the design and analysis of a LCLC compensated bidirectional capacitive wireless power transfer (CPT) system for electric vehicle charging applications. The bidirectional power flow enables the system to operate in vehicle to grid and grid to vehicle mode. A closed loop control scheme for the bidirectional power flow through phase shift control method is introduced and some of the power flow control methods are discussed. The design and frequency response analysis of the LCLC compensation network is also discussed. The compensation circuit is designed to resonate at a frequency of 1 MHz which is chosen as the switching frequency of the system. The CPT system is designed for a power level of 300 W. The theoretical calculation of active and reactive power is discussed along with the phasor diagram representation of various quantities. An introduction to soft-switching is also discussed since it is important while operating at high frequencies like 1 MHz. The simulations are done using digital simulation platforms considering SiC MOSFETs.