Miracle-dz/UniFAR-FTUs huggingface dataset:
Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3

During antigen-induced immune responses, human B cells switch isotype from immunoglobulin M (IgM)-IgD to IgG1-4, IgA1-2, or IgE. In the human, no cytokines have yet been demonstrated to act as switch factors for IgG1, IgG2, and IgG3. In this paper, we report that in response to interleukin 10 (IL-10), anti-CD40 activated tonsillar surface IgD+ (sIgD+) B cells are induced to secrete large amounts of IgM, IgG1, and IgG3 but neither IgG2 nor IgG4. Cord blood purified B cells and lymphocytes from Hyper-IgM patients also produced IgG1 and IgG3 after culture with anti-CD40 and IL-10. In contrast, sIgD- isotype-committed B cells produce IgG1, IgG2, and IgG3 when activated through CD40 in the presence of IL-10. Thus, in addition to its growth-promoting and differentiating activities on human B cells, IL-10 may represent a switch factor for IgG1 and IgG3.
A LOUDNESS MODEL BASED SOUND ONSET DETECTION ALGORITHM

We present a sound onset detection algorithm and it’s three variants. The algorithms use Moore’s loudness model for hearing to detect changes in loudness as sound onsets. Loudness, measured in sones, is used to build a detection function that grossly represents the human response to complex audio onsets. This leads to a simple thresholding strategy that has both physical and perceptual significance as against many of the thresholding methods used in current literature. The performance of the algorithms on a database of both monophonic and polyphonic audio gradually improved as we made changes to the basic algorithm.
Somatostatin for Postoperative Chylothorax after Surgery for Children with Congenital Heart Disease

Chylothorax is a rare but serious postoperative condition with a high rate of morbidity that may lead to death of children with congenital heart disease. Here we reviewed nine consecutive cases with chylothorax in infants and children following cardiac surgery from March 2002 to February 2003. Somatostatin was added to conservative treatment proctocol to increase effectiveness of therapy in all cases. The duration of somatostatin therapy varied from 7 to 32 days. All cases of chylothorax were successfully treated with intravenous infusion of somatostatin as an adjunctive treatment. Even though two cases showed rebound phenomena, we avoided any surgical procedure in the nine patients who treated with conservative management combined with somatostatin. No significant side effects of somatostatin were observed. It seems that somatostatin is effective, noninvasive and safe therapeutic modality. It can be used as an adjunctive treatment to conservative management to control postoperative chylothorax in children with congenital heart disease.
MECHANISM OF THYMUS-INDEPENDENT IMMUNOCYTE TRIGGERING

The present experiments were performed in order to analyze the mechanism by which thymus-independent antigens (nonspecific B-cell mitogens) can induce specific immune responses to antigenic determinants present on the same molecule. The hapten NNP was coupled to the B-cell mitogen, lipopolysaccharide (LPS). The conjugate retained full mitogenic activity and bound specifically to NNP-reactive cells. NNP-LPS activated polyclonal as well as specific anti-NNP antibody synthesis, but the optimal concentrations for induction of specific anti-NNP cells were several orders of magnitude lower than the concentrations required for polyclonal activation. These low concentrations failed to activate nonspecific cells, but they induced specific thymus-independent responses of high-avidity NNP-specific cells with the typical kinetics of antigenic responses in vitro. Furthermore, hapten-specific cells were paralyzed by NNP-LPS concentrations that were optimal for induction of polyclonal activation. Specific activation and paralysis could be abolished by free hapten indicating that selective binding of NNP-LPS to hapten-specific cells was responsible for the specificity of the response. However, the triggering signal lacked specificity, since high-avidity specific anti-NNP cells could still be activated by stimulating concentrations of NNP-LPS in the presence of free hapten, even though the Ig receptor combining sites were presumably occupied by NNP. The findings show that B cells with specific Ig receptors for the antigenic determinants on mitogen molecules preferentially bind these molecules and become activated at concentrations still unsufficient to trigger other B cells that lack specific receptors. It is suggested that activation for primary IgM responses in B cells is the result of "one nonspecific signal. " This nonspecific signal is provided by the mitogenic properties of some antigens (highly thymus independent or, alternatively, by nonspecific T-cell factors (for highly T cell-dependent antigens), or both, and the surface structures responsible for triggering are not the Ig receptors. The specific Ig receptors only act as passive focusing devices for nonspecific stimuli, entitling the cell to be selectively activated, even though both the signal and the receptors for the triggering are nonspecific.
The Relevance of Customers as a Source of Knowledge in IT Firms

The overall aim and contribution of this chapter is to identify the main sources of knowledge generation in IT-related SMEs and the organizational elements that support this process. Knowledge generation occurs through external knowledge acquisition and internal knowledge creation. The latter process is facilitated by personal motivation and the learning opportunities it offers to the organization’s employees, who play a key role as initiative and suggestion carriers. In order to evaluate the phenomenon under study, which the literature review reflects as an incipient stage, two-step exploratory research was conducted. In the first stage, eight interviews were conducted in four firms. The objective of the second phase was to validate some of the insight from the first stage
How to make a greedy heuristic for the asymmetric traveling salesman problem competitive

It is widely confirmed by many computational experiments that a greedy type heuristics for the Traveling Salesman Problem (TSP) produces rather poor solutions except for the Euclidean TSP. The selection of arcs to be included by a greedy heuristic is usually done on the base of cost values. We propose to use upper tolerances of an optimal solution to one of the relaxed Asymmetric TSP (ATSP) to guide the selection of an arc to be included in the final greedy solution. Even though it needs time to calculate tolerances, our computational experiments for the wide range of ATSP instances show that tolerance based greedy heuristics is much more accurate an faster than previously reported greedy type algorithms
Comparisons of Internal Behavior after Exposure to Flavobacterium psychrophilum between Two Ayu (Plecoglossus altivelis altivelis) Strains Showing Different Cumulative Mortality to Bacterial Cold Water Disease

ABSTRACT Bacterial cold water disease (BCWD) in ayu (Plecoglossus altivelis altivelis) has a serious impact on aquaculture and fisheries. There is known to be a significant difference among ayu strains with regard to mortality caused by BCWD. In this study, the immune response of different ayu strains against Flavobacterium psychrophilum infection was observed. One strain was resistant to infection by F. psychrophilum, and the other was susceptible to infection by the same bacteria. The number of bacteria in the body was observed in each ayu strain, and the change in bacterial counts was similar. However, there was a significant difference in bacterial count in the spleen between the two strains on days 6, 9, 12 and 15 after exposure. To observe the immune response against F. psychrophilum, agglutination assay using serum was performed. An agglutination reaction in the resistant ayu strain was observed in 4 out of 6 ayu on day 6 after exposure, while no reactions in the susceptible ayu strain were observed in any sampled fish until day 12. However, some reactions in the susceptible ayu strain were observed in surviving ayu. These results indicate that there is a correlation between the presence of bacterial multiplication and agglutination reaction against F. psychrophilum.
Serum gamma glutamyl transferase and alanine transaminase concentrations predict endothelial dysfunction in patients with non-alcoholic steatohepatitis

Abstract Purpose. Cardiovascular diseases are the leading cause of death in patients with non-alcoholic steatohepatitis (NASH). We aimed to investigate the presence of endothelial dysfunction and whether serum concentrations of liver enzymes may reflect the severity of such an endothelial dysfunction in patients with NASH. Methods. Fifty patients with NASH diagnosed by liver biopsies and 30 healthy controls were included. Blood samples after fasting were harvested for measurements of glucose, insulin, cholesterol, triglyceride, and liver enzymes. All patients underwent transthoracic echocardiography and brachial and carotid artery Doppler ultrasonography to evaluate flow-mediated dilatation (FMD) and carotid artery intima-media thickness (CIMT). Results. Patients with NASH had impaired FMD (4.9 ± 2.8% to 9.3 ± 4.4%, P < 0.001) and higher CIMT (0.79 ± 0.16 mm to 0.64 ± 0.11 mm, P < 0.001) when compared with healthy controls. Linear regression analyses revealed that serum concentrations of gamma glutamyl transferase (GGT) and alanine transaminase (ALT) were associated with FMD and CIMT. Conclusions. Patients with NASH have impaired FMD and increased CIMT when compared with healthy controls. In patients with NASH, serum concentrations of GGT and ALT might have a predictive value for FMD and CIMT.
Distribution theory and inference for polynomial-normal densities

This paper considers a class of densities formed by taking the product of nonnegative polynomials and normal densities. These densities provide a rich class of distributions that can be used in modelling when faced with non-normal characteristics such as skewness and multimodality. In this paper we address inferential and computational issues arising in the practical implementation of this parametric family in the context of the linear model. Exact results are recorded for the conditional analysis of location-scale models and an importance sampling algorithm is developed for the implementation of a conditional analysis for the general linear model when using polynomial-normal distributions for the error.
Performance analysis of contention-based channel reservation schemes in wireless communication systems

This paper presents an original performance analysis of the contention-based channel reservation schemes, namely UNI MAC in wireless communication systems. Here we mathematically derive the expression of the performance in term of success rate where the impact of misbehaving users is also taken into account. Validated with the simulation results, our numerical results show that the overall performance is degraded while a single misbehaving user exists. Furthermore, it is found that the severity of degradation depends on the important factors, i.e. misbehaving scenario and the number of misbehaving users.
Sub-image extraction by learnt lifting wavelet filters

This paper proposes a method for extracting sub-images from a huge reference image by using learnt lifting wavelet filters. Lifting wavelet filters are biorthogonal wavelet filters containing free parameters developed by Sweldens. Our method is to learn such free parameters using some training sub-images so as to eliminate their high frequency components. The learnt wavelet filters have the feature of training sub-images. Applying such wavelet filters to the reference image, we can detect the area which has almost the same high frequency components as those of the target sub-image.
Capitalizing on Appraisal Processes to Improve Affective Responses to Social Stress

Regulating affective responses to acute stress has the potential to improve health, performance, and well-being outcomes. Using the biopsychosocial (BPS) model of challenge and threat as an organizing framework, we review how appraisals inform affective responses and highlight research that demonstrates how appraisals can be used as regulatory tools. Arousal reappraisal, specifically, instructs individuals on the adaptive benefits of stress arousal so that arousal is conceptualized as a coping resource. By reframing the meaning of signs of arousal that accompany stress (e.g., racing heart), it is possible to break the link between stressful situations, and malignant physiological responses and experiences of negative affect. Applications of arousal reappraisal for academic contexts and clinical science, and directions for future research are discussed.
Verification in Referral-Based Crowdsourcing

Online social networks offer unprecedented potential for rallying a large number of people to accomplish a given task. Here we focus on information gathering tasks where rare information is sought through “referral-based crowdsourcing”: the information request is propagated recursively through invitations among members of a social network. Whereas previous work analyzed incentives for the referral process in a setting with only correct reports, misreporting is known to be both pervasive in crowdsourcing applications, and difficult/costly to filter out. A motivating example for our work is the DARPA Red Balloon Challenge where the level of misreporting was very high. In order to undertake a formal study of verification, we introduce a model where agents can exert costly effort to perform verification and false reports can be penalized. This is the first model of verification and it provides many directions for future research, which we point out. Our main theoretical result is the compensation scheme that minimizes the cost of retrieving the correct answer. Notably, this optimal compensation scheme coincides with the winning strategy of the Red Balloon Challenge.
High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California

We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3–33.4; P < .001); the odds ratio was 8.9 (95% CI, 4.1–19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships.
Finite-horizon energy allocation and routing scheme in rechargeable sensor networks

In this paper, we investigate the problem of maximizing the throughput over a finite-horizon time period for a sensor network with energy replenishment. The finite-horizon problem is important and challenging because it necessitates optimizing metrics over the short term rather than metrics that are averaged over a long period of time. Unlike the infinite-horizon problem, the fact that inefficiencies cannot be made to vanish to infinitesimally small values, means that the finite-horizon problem requires more delicate control. The finite-horizon throughput optimization problem can be formulated as a convex optimization problem, but turns out to be highly complex. The complexity is brought about by the “time coupling property,” which implies that current decisions can influence future performance. To address this problem, we employ a three-step approach. First, we focus on the throughput maximization problem for a single node with renewable energy assuming that the replenishment rate profile for the entire finite-horizon period is known in advance. An energy allocation scheme that is equivalent to computing a shortest path in a simply-connected space is developed and proven to be optimal. We then relax the assumption that the future replenishment profile is known and develop an online algorithm. The online algorithm guarantees a fraction of the optimal throughput. Motivated by these results, we propose a low-complexity heuristic distributed scheme, called NetOnline, in a rechargeable sensor network. We prove that this heuristic scheme is optimal under homogeneous replenishment profiles. Further, in more general settings, we show via simulations that NetOnline significantly outperforms a state-of-the-art infinite-horizon based scheme, and for certain configurations using data collected from a testbed sensor network, it achieves empirical performance close to optimal.
Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites

Interleukin- (IL-) 10, anti-inflammatory cytokine, is known to inhibit the protective immune responses against malaria parasites and to be involved in exacerbating parasitemia during Plasmodium infection. In contrast, IL-10 is regarded as necessary for suppressing severe pathology during Plasmodium infection. Here, we summarize the role of IL-10 during murine malaria infection, focusing especially on coinfection with lethal and nonlethal strains of malaria parasites. Recent studies have demonstrated that the major sources of IL-10 are subpopulations of CD4+ T cells in humans and mice infected with Plasmodium. We also discuss the influence of innate immunity on the induction of CD4+ T cells during murine malaria coinfection.
Reliability-configurable mixed-grained reconfigurable array supporting C-to-array mapping and its radiation testing

This paper presents a mixed-grained reconfigurable VLSI array architecture that can cover mission-critical applications to consumer products through C-to-array application mapping. A proof-of-concept VLSI chip was fabricated in 65nm process. Measurement results show that applications on the chip can be working in a harsh radiation environment. Irradiation tests also show the correlation between the number of sensitive bits and the mean time to failure. Furthermore, the temporal error rate of an example application due to soft errors in the datapath were measured and demonstrated for reliability-aware mapping.
Statistical profiling of hospital performance using acute coronary syndrome mortality

Background In order to improve the quality of care delivered to patients and to enable patient choice, public reports comparing hospital performances are routinely published. Robust systems of hospital ‘report cards’ on performance monitoring and evaluation are therefore crucial in medical decision-making processes. In particular, such systems should effectively account for and minimise systematic differences with regard to definitions and data quality, care and treatment quality, and ‘case mix’. Methods Four methods for assessing hospital performance on mortality outcome measures were considered. The methods included combinations of Bayesian fixed- and random-effects models, and risk-adjusted mortality rate, and rank-based profiling techniques. The methods were empirically compared using 30-day mortality in patients admitted with acute coronary syndrome. Agreement was firstly assessed using median estimates between risk-adjusted mortality rates for a hospital and between ranks associated with a hospital’s risk-adjusted mortality rates. Secondly, assessment of agreement was based on a classification of hospitals into low, normal or high performing using risk-adjusted mortality rates and ranks. Results There was poor agreement between the point estimates of risk-adjusted mortality rates, but better agreement between ranks. However, for categorised performance, the observed agreement between the methods’ classification of the hospital performance ranged from 90 to 98%. In only two of the six possible pair-wise comparisons was agreement reasonable, as reflected by a Kappa statistic; it was 0.71 between the methods of identifying outliers with the fixed-effect model and 0.77 with the hierarchical model. In the remaining four pair-wise comparisons, the agreement was, at best, moderate. Conclusions Even though the inconsistencies among the studied methods raise questions about which hospitals performed better or worse than others, it seems that the choice of the definition of outlying performance is less critical than that of the statistical approach. Therefore there is a need to find robust systems of ‘regulation’ or ‘performance monitoring’ that are meaningful to health service practitioners and providers.
Thyroid Hormone Stimulates Renin Gene Expression Through the Thyroid Hormone Response Element

We previously reported that thyroid hormone stimulates renin synthesis in vivo and in vitro. Here, we analyzed the 5′-flanking sequence of the human renin gene for promoter activity responsive to thyroid hormone using Calu-6 cells, which secrete renin endogenously and express thyroid hormone receptor-&bgr;. The luciferase reporter gene was cloned together with 5′-flanking portions of the human renin gene of various lengths into the pGL3-Basic vector. Luciferase activity assays were performed using the Dual Luciferase Reporter Assay System. 3,3′,5-Triiodo-l-thyronine stimulated the promoter activity of pGL3-Basic−1111/+12 and pGL3-Basic−1298/+12 by 2.3±0.1- and 1.7±0.1-fold, respectively. Shorter constructs (pGL3-Basic−144/+12, pGL3-Basic−226/+12, pGL3-Basic−452/+12, and pGL3-Basic−953/+12) were not stimulated by thyroid hormone. These results suggest that there is a possible thyroid hormone response element (5′-AGG TCA GGT CAc aat GTT CCT-3′) between nucleotides −1111 and −953. In 3 constructs with site-directed mutations in this sequence, basal promoter activities were significantly increased, whereas promoter activation by thyroid hormone was abolished. Electrophoretic mobility shift assays showed that the −1111/−953 DNA fragment of the intact human renin gene was bound to nuclear proteins of Calu-6 cells; however, none of the 3 mutant probes were bound to any nuclear proteins. These results suggest that thyroid hormone stimulates the promoter activity of the human renin gene through thyroid hormone response element–dependent mechanisms in Calu-6 cells.
Tools and libraries to model and manipulate circular programs

This paper presents techniques to model circular lazy programs in a strict, purely functional setting. Circular lazy programs model any algorithm based on multiple traversals over a recursive data structure as a single traversal function. Such elegant and concise circular programs are defined in a (strict or lazy) functional language and they are transformed into efficient strict and deforested, multiple traversal programs by using attribute grammars-based techniques. Moreover, we use standard slicing techniques to slice such circular lazy programs. We have expressed these transformations as an Haskell library and two tools have been constructed: the HaCirc tool that refactors Haskell lazy circular programs into strict ones, and the OCirc tool that extends Ocaml with circular definitions allowing programmers to write circular programs in Ocaml notation, which are transformed into strict Ocaml programs before they are executed. The first benchmarks of the different implementations are presented and show that for algorithms relying on a large number of traversals the resulting strict, deforested programs are more efficient than the lazy ones, both in terms of runtime and memory consumption.