Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and safety of Keluoxin capsule in combination with Western medicine for diabetic kidney disease: A systematic review and meta-analysis

Objective: Keluoxin capsule (KLXC) has been widely used in diabetic kidney disease (DKD), but its efficacy and safety have not yet been clarified. A systematic review and meta-analysis were performed to assess the efficacy and safety of KLXC for DKD. Methods: The randomized control trials (RCTs) included KLXC searched from seven major English and Chinese databases up until 3 June 2022. The methodological quality and risk of bias were assessed by version 2 of the Cochrane risk-of-bias tool (RoB 2) for the RCTs from the Cochrane Handbook. The analyses were conducted by RevMan 5.4 and Stata 17.0. Results: A total of 20 trials with 1,500 participants were identified. The meta-analysis showed that KLXC combined with Western medicine was superior to the use of Western medicine alone for DKD which included improvements in the estimated glomerular filtration rate (eGFR) [MD = 3.04, 95% CI (0.30, 5.78), p = 0.03], reduction in microalbuminuria (mALB) [MD = −25.83, 95% CI (−41.20, −10.47), p = 0.001], urinary albumin excretion rate (UAER) [SMD = −0.97, 95% CI (−1.50, −0.44), p = 0.0003], 24-h urine protein (24hUpro) [SMD = −1.31, 95% CI (−1.82, −0.80), p < 0.00001], serum creatinine (Scr) [MD = −11.39, 95% CI (−18.76, −4.02), p = 0.002], blood urea nitrogen (BUN) [MD = −1.28, 95% CI (−1.67, −0.88), p < 0.00001], fasting blood glucose (FBG) [MD = −0.51, 95% CI (−0.90, −0.11), p = 0.01], total cholesterol (TC) [MD = −1.04, 95% CI (−1.40, −0.68), p < 0.00001], triglycerides (TG) [MD = −0.36, 95% CI (−0.50, −0.23), p < 0.00001], and low-density lipoprotein cholesterol (LDL) [MD = −0.39, 95% CI (−0.71, −0.07), p = 0.02]. Results showed no statistically significant difference in glycated hemoglobin (HbA1c) (p = 0.14) or adverse events (p = 0.81) between the two groups. Conclusion: The combination of KLXC and Western medicine had a positive effect on DKD. However, due to the high clinical heterogeneity and low quality of included studies, further standardized, large-scale, rigorously designed RCTs for DKD in the definitive stage are still necessary to achieve more accurate results. Systematic Review Registration: https://inplasy.com/inplasy-2021-11-0067/, identifier INPLASY 2021110067.
What future are you talking about? Efficacy of Life Design Psy-Lab, as career guidance intervention, to support university students’ needs during COVID-19 emergency

The pandemic increased world’s uncertainty, and led to deep change in daily habits, generating disorientation, and inevitably affecting people life and professional plans. Young adults and students’ future perspective and satisfaction with life were widely affected, especially for those facing school/ work transitions. Nevertheless, it was of primary importance for career guidance psychologists to intervene to support students despite having to navigate “on sight” and with little literature available. This paper will thus describe how the Life Design Psy-Lab, a career guidance service from Bicocca University (Milan, Italy) implemented a thematic online group intervention with 103 students enrolled. The intervention was based on the theoretical model of Life Design and was performed by career counselling psychologists. The intervention’s goal was to foster students’ development of skills and mindset to face complexity and unpredictability, shifting their time perception from an uncertain present to a more optimistic future scenario. The intervention’s impact was assessed using pre and post online questionnaires. Results show how students increased their precepted level in a set of skills to face change and complexity after participating to the intervention. In more detail, students’ precepted levels of career adaptability, courage, time perspective and resilience rose. Also, data show how the intervention strengthened students’ life satisfaction. This paper will thus contribute to expand the growing yet still newborn set of knowledge about career guidance interventions in times of COVID-19 emergency, specifically addressing the issue of design interventions that can improve young adults’ skills to visualize and project present and future for themselves, especially during uncertain times.
Physical symptoms as psychiatric manifestations in medical spaces: A qualitative study

Background Mental health and physical health issues frequently co-occur, but the impact of the psychological wellbeing on the body's physical functioning remains poorly understood within medical spaces. Individuals living with psychiatric diagnoses in particular are at an increased risk for developing chronic health issues and may be especially disadvantaged by healthcare systems which treat the mind and body as separate entities. Methods We used secondary analysis (SA) to analyze 30 semi-structured interviews of individuals living with a serious mental illness or reflecting on a family member living with a serious mental illness. We deliberately sampled participants who reflected on salient experiences with co-occurring physical and mental health symptoms. All participants were associated with the National Alliance on Mental Illness (NAMI), the nation's largest grassroots mental health organization. We coded interviews using qualitative thematic analysis with an interpretative phenomenological framework centered on participants' subjective experiences. Results Our analyses uncovered physical health challenges which often occur in individuals living with a psychiatric illness, emphasizing the bidirectionality of mental and physical symptoms. We identified three overarching domains: (i) manifestations, in which participants reflected on how their body responded physically to mental states; (ii) medical management, in which they discussed challenging experiences seeking medical treatment for physical symptoms while living with a mental health condition; and (iii) disjointedness, in which they reflected on challenges in navigating poorly coordinated mental and physical healthcare systems. Discussion Participants and their medical providers struggled to incorporate mental wellbeing and its impact on physical health into overall healthcare. Given common experiences with misdiagnoses, difficulties navigating health care, and significantly delayed treatment, medical spaces may be able to improve patient experiences and satisfaction by accounting for psychological influences on health outcomes. Conclusion Greater integration of physical and mental health care in medical spaces could improve health outcomes and reduce challenges for patients seeking treatment.
Mapping of a QTL associated with sucrose content in peanut kernels using BSA-seq

As an important factor affecting the edible quality of peanut kernels, sucrose content is a complex quantitative trait regulated by multiple factors. In this study, an F2 segregating population and a recombinant inbred line (RIL) population, derived from a cross between the high sucrose content variety Jihuatian 1 and the low sucrose content line PI478819, were used as materials to map a quantitative trait locus (QTL) associated with sucrose content in peanut kernels. Four QTLs were initially located on chromosomes A03 and A06 based on BSA-seq technology, and multiple kompetitive allele-specific PCR markers were developed based on single-nucleotide polymorphisms (SNPs) in the intervals. The markers were genotyped in the RIL population and finely mapped to a stable QTL, qSUCA06, located on chromosome A06 within a 0.29-Mb physical genomic interval (112367085–112662675 bp), which accounted for 31.95%–41.05% of the phenotypic variance explained. SNP and insertion/deletion annotations were performed on genes in the candidate interval, and having screened out those genes with mutations in exons, candidate genes were verified by qRT-PCR. The results revealed that Arahy.Y2LWD9 may be the main gene regulating sucrose content. The QTL identified in this study will not only contribute to marker-assisted breeding for improvement of peanut sucrose content but also paves the way for identifying gene function.
Nexus between agriculture productivity and carbon emissions a moderating role of transportation; evidence from China

This research investigates the nexus existing between agricultural productivity and CO2 emissions under the moderating effect of transportation within the context of China. The data for this study are drawn from the World Bank and cover the period 1991–2019. The data is analyzed using an autoregressive distributed lag approach (ARDL). Agricultural productivity is measured in terms of crop and livestock production. The goal of this research is to make some contributions, as crop production has a negative impact on carbon dioxide emissions in the long and short run. Carbon dioxide emissions are positively influenced by livestock production in the long run, but negatively in the short run. As for the moderation effect, the results indicate that transportation significantly impacts agricultural productivity and CO2 in both the long and short term. The study provides in-depth insights to policy makers for designing more suitable policies regarding the necessity of decreasing CO2 emissions. In addition to discussing the crucial implications, future directions are also discussed.
Mesoangioblasts at 20: From the embryonic aorta to the patient bed

In 2002 we published an article describing a population of vessel-associated progenitors that we termed mesoangioblasts (MABs). During the past decade evidence had accumulated that during muscle development and regeneration things may be more complex than a simple sequence of binary choices (e.g., dorsal vs. ventral somite). LacZ expressing fibroblasts could fuse with unlabelled myoblasts but not among themselves or with other cell types. Bone marrow derived, circulating progenitors were able to participate in muscle regeneration, though in very small percentage. Searching for the embryonic origin of these progenitors, we identified them as originating at least in part from the embryonic aorta and, at later stages, from the microvasculature of skeletal muscle. While continuing to investigate origin and fate of MABs, the fact that they could be expanded in vitro (also from human muscle) and cross the vessel wall, suggested a protocol for the cell therapy of muscular dystrophies. We tested this protocol in mice and dogs before proceeding to the first clinical trial on Duchenne Muscular Dystrophy patients that showed safety but minimal efficacy. In the last years, we have worked to overcome the problem of low engraftment and tried to understand their role as auxiliary myogenic progenitors during development and regeneration.
Geochemical records in subaerial exposure environments in Croatia using discriminant function analysis of bauxite data

Croatian bauxites are long known for their chemical and physical diversity arisen from their characteristic origin and emplacement within the area of the Adriatic–Dinaric carbonate platform (ADCP). They include eight horizons spanning the period between the Upper Triassic (Carnian) and the Miocene, formed on subaerially exposed platform paleoenvironments. The bauxite genesis is recorded in the bauxite geochemical composition as a unique signature of tectonostratigraphic evolution of the different parts of the Croatian Karst, including, for example, the forebulge unconformity typical for the Istrian area. In this work, an explanation of the typical patterns of bauxite formation is based on the construction of a discriminant function model (DFM) resulting from the compositional data (CoDa) analysis of bauxite geochemical data (major and trace elements). The model shows that the greatest part of the variation contained in the analyzed bauxite data (the first discriminant function, DF1) is associated with systematic alteration of geochemical composition in time, emphasizing characteristic decrease in clay component and gradual enrichment in heavy metals from oldest (Upper Triassic) to the youngest (Miocene) bauxites. In the general scheme, particular bauxite horizons represent standalone groups (Upper Triassic) while others form clusters showing increase and/or decrease of a particular set of elements signaling the changes in environmental conditions during the considered geological history of ADCP. Other discriminant functions (DF2 and DF3) also contribute to the all-inclusive distinction between the eight a priori defined bauxite groups discriminated by the characteristic set of geochemical variables where DF2 typically refers to the process of desilication, while DF3 to that of deferralitization.
A review of concrete 3D printed structural members

Concrete 3D Printing (3DP) is a potential technology for increasing automation and introducing digital fabrication in the construction industry. Concrete 3D Printing provides a significant advantage over conventional or precast methods, such as the prospects of topologically optimized designs and integrating functional components within the structural volume of the building components. Many previous studies have compiled state-of-art studies in design parameters, mix properties, robotic technologies, and reinforcement strategies in 3D printed elements. However, there is no literature review on using concrete 3D Printing technology to fabricate structural load-carrying elements and systems. As concrete 3DP is shifting towards a large-scale construction technology paradigm, it is essential to understand the current studies on structural members and focus on future studies to improve further. A systematic literature review process is adopted in this study, where relevant publications are searched and analyzed to answer a set of well-defined research questions. The review is structured by categorizing the publications based on issues/problems associated with structural members and the recent technology solutions developed. It gives an overall view of the studies, which is still in its nascent stage, and the areas which require future focus on 3D printing technology in large-scale construction projects.
Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia

With approximately 220,000 newly diagnosed cases per year, ovarian cancer is among the most frequently occurring cancers among women and the second leading cause of death from gynecological malignancies worldwide. About 70% of these cancers are diagnosed in advanced stages (FIGO IIB–IV), with a 5-year survival rate of 20–30%. Due to the poor prognosis of this disease, research has focused on its pathogenesis and the identification of prognostic factors. One possible approach for the identification of biological markers is the identification of tumor entity-specific genetic “driver mutations”. One such mutation is 3q26 amplification in the tumor driver SEC62, which has been identified as relevant to the pathogenesis of ovarian cancer. This study was conducted to investigate the role of SEC62 in ovarian malignancies. Patients with ovarian neoplasias (borderline tumors of the ovary and ovarian cancer) who were treated between January 2007 and April 2019 at the Department of Gynecology and Obstetrics, Saarland University Hospital, were included in this retrospective study. SEC62 expression in tumor tissue samples taken during clinical treatment was assessed immunohistochemically, with the calculation of immunoreactivity scores according to Remmele and Stegner, Pathologe, 1987, 8, 138–140. Correlations of SEC62 expression with the TNM stage, histological subtype, tumor entity, and oncological outcomes (progression-free and overall survival) were examined. The sample comprised 167 patients (123 with ovarian cancer and 44 with borderline tumors of the ovary) with a median age of 60 (range, 15–87) years. At the time of diagnosis, 77 (46%) cases were FIGO stage III. All tissue slides showed SEC62 overexpression in tumor cells and no SEC62 expression in other cells. Median immunoreactivity scores were 8 (range, 2–12) for ovarian cancer and 9 (range, 4–12) for borderline tumors of the ovary. Patients with borderline tumors of the ovary as well as patients with ovarian cancer and an immunoreactive score (IRS) ≤ 9 showed an improved overall survival compared to those presenting with an IRS score >9 (p = 0.03). SEC62 seems to be a prognostic biomarker for the overall survival of patients with ovarian malignancies.
The impact of violating the independence assumption in meta-analysis on biomarker discovery

With rapid advancements in high-throughput sequencing technologies, massive amounts of “-omics” data are now available in almost every biomedical field. Due to variance in biological models and analytic methods, findings from clinical and biological studies are often not generalizable when tested in independent cohorts. Meta-analysis, a set of statistical tools to integrate independent studies addressing similar research questions, has been proposed to improve the accuracy and robustness of new biological insights. However, it is common practice among biomarker discovery studies using preclinical pharmacogenomic data to borrow molecular profiles of cancer cell lines from one study to another, creating dependence across studies. The impact of violating the independence assumption in meta-analyses is largely unknown. In this study, we review and compare different meta-analyses to estimate variations across studies along with biomarker discoveries using preclinical pharmacogenomics data. We further evaluate the performance of conventional meta-analysis where the dependence of the effects was ignored via simulation studies. Results show that, as the number of non-independent effects increased, relative mean squared error and lower coverage probability increased. Additionally, we also assess potential bias in the estimation of effects for established meta-analysis approaches when data are duplicated and the assumption of independence is violated. Using pharmacogenomics biomarker discovery, we find that treating dependent studies as independent can substantially increase the bias of meta-analyses. Importantly, we show that violating the independence assumption decreases the generalizability of the biomarker discovery process and increases false positive results, a key challenge in precision oncology.
A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation

Repair of large oral bone defects such as vertical alveolar ridge augmentation could benefit from the rapidly developing additive manufacturing technology used to create personalized osteoconductive devices made from porous tricalcium phosphate/hydroxyapatite (TCP/HA)-based bioceramics. These devices can be also used as hydrogel carriers to improve their osteogenic potential. However, the TCP/HA constructs are prone to brittle fracture, therefore their use in clinical situations is difficult. As a solution, we propose the protection of this osteoconductive multi-material (herein called “core”) with a shape-matched “cover” made from biocompatible poly-ɛ-caprolactone (PCL), which is a ductile, and thus more resistant polymeric material. In this report, we present a workflow starting from patient-specific medical scan in Digital Imaging and Communications in Medicine (DICOM) format files, up to the design and 3D printing of a hydrogel-loaded porous TCP/HA core and of its corresponding PCL cover. This cover could also facilitate the anchoring of the device to the patient's defect site via fixing screws. The large, linearly aligned pores in the TCP/HA bioceramic core, their sizes, and their filling with an alginate hydrogel were analyzed by micro-CT. Moreover, we created a finite element analysis (FEA) model of this dual-function device, which permits the simulation of its mechanical behavior in various anticipated clinical situations, as well as optimization before surgery. In conclusion, we designed and 3D-printed a novel, structurally complex multi-material osteoconductive-osteoprotective device with anticipated mechanical properties suitable for large-defect oral bone regeneration.
The Impact of Religion and Spirituality on Suicide Risk in Veterans and Refugees With Posttraumatic Stress Disorder

Abstract It has been suggested that religion and spirituality have a protective impact on suicide risk in populations living with posttraumatic stress disorder (PTSD). This review sought to examine the association between suicide risk among veterans and refugees with PTSD and religion or spirituality as a modifying factor. Two databases, PubMed and Embase, were searched and 10 publications were identified and included. Seven publications found that religion or spirituality was associated with lower suicide risk. The findings in this study suggest that religion and spirituality contain social as well as psychological domains, which should be considered in future interventions and in strategies of prevention of suicide in populations with PTSD. Further high-quality research with well-defined terms of religion and spirituality that investigates the connection to suicide risk of veterans and refugees with PTSD is recommended.
Aalborg Universitet Gamifying Navigation in Location-Based Applications

Location-based games entertain players usually by interactions at points of interest (POIs). Navigation between POIs often involve the use of either a physical or digital map, not taking advantage of the opportunity available to engage users in activities between POIs. The paper presents riddle solving as a navigational method for a location-based game. 10 families with 2-6 persons and at least one child in the age range 911 years old participated in the evaluation. Results show that riddle solving as a navigational method is more enjoyable than a 2D digital map. Additional findings from video recordings, field notes, questionnaires, logging and semi-structured interviews revealed that riddle solving has potential for engaging users in learning activities. Received on 22 November 2016; accepted on 06 October 2017; published on 08 November 2017
MULTIBLOCK IMPLEMENTATION STRATEGY FOR A 3-D PRESSURE-BASED FLOW AND HEAT TRANSFER SOLVER

This article reports on a multiblock implementation of a general three-dimensional single-block computational fluid dynamics code, which is developed in a nonorthogonal, structured, collocated finite-volume grid system, and incorporates a range of turbulence models. The multiblock implementation is essentially block-unstructured, each block having its own local coordinate system unrelated to those of its neighbors. Any of the blocks may interface with more than one neighbor along any block face. Interblock communication is handled by inner-boundary connection information (receive and send point index arrays) and effected via two-layer dummy cells along interblock boundaries. This communication procedure is easy to extend to parallel computation. The implementation of the algorithm, which takes the advantage of Fortran 90, employs a method to keep most of the single-block code unchanged. Two cases are presented to validate the implementation, and another case with a block number ranging from 1 to 160 blocks is presented for test of the influence of the multiblocking on the convergence rate and execution time.