Miracle-dz/UniFAR-FTUs huggingface dataset:
VISUAL HALLUCINATIONS OF THE SELF IN ORGANIC DISEASE

There are few references to autoscopy in medical literature, and almost all recorded cases are to be found in Continental journals. Most frequently it has been noted in epileptics (Genner, 1947; and Lhermitte, 1951a, b). Sivadon (1937) describes the case of a doctor suLffering from influenza who saw himself on his way to hospital; and Skvortzoff (1931) records similar visual aberrations in patients with functional disorders of the labyrinth. Nouet (1923) reported autoscopic hallucinations in a patient with a fragment of shrapnel lodged in the right temporal lobe. Hallucinations of the self have also been described in patients suffering from infectious fevers (particularly typhus), general paralysis of the insane, brain tumours, or post-traumatic cerebral lesions (Lhermitte, 1937, 1951a, b). Three further cases of autoscopic hallucinations in association with organic lesions are presented. Those afflicted were fully aware that these visions resulted from their illness and were unreal; but whereas the first two patients were ill disposed to discuss the details of their experiences, the hallucinations of the third subject were so persistent as to provoke this sole presenting symptom.
Beta3-adrenoreceptor agonist mirabegron – a potential antiobesity drug?

Mirabegron is the first β3-adrenoreceptor (AR) agonist which was approved for the treatment of overactive bladder (OAB) in the United States, Japan, the European Union, and Canada at a dose of 50 mg daily [1]. Three phase III clinical trials lasting 12 weeks and one carried out over 12 months confirmed its efficacy, good tolerability, and safety in patients with OAB [2]. The clinical profile of mirabegron was comparable to antimuscarinics, the most commonly prescribed drugs for the treatment of OAB, except for dry mouth which occurred five times less frequently with mirabegron. β3-AR agonists were investigated for over three decades primarily as potential antiobesity drugs devoid of cardiovascular adverse events (AEs) associated with administration of conventional adrenergic agonists [3]. Most of these drugs exerted favorable metabolic effects in experimental studies conducted in rodents but they failed in the clinical trials in humans due to their β1and β2-AR-mediated cardiovascular AEs [3]. Recently described mirabegron-induced activation of human brown adipose tissue (BAT) by Cypess et al., however, led us to reconsider a potential role of mirabegron in weight management [4].
Performance-Led Research in the Wild

We explore the approach of performance-led research in the wild in which artists drive the creation of novel performances with the support of HCI researchers that are then deployed and studied at public performance in cultural settings such as galleries, festivals and on the city streets. We motivate the approach and then describe how it consists of three distinct activities -- practice, studies and theory -- that are interleaved in complex ways through nine different relationships. We present a historical account of how the approach has evolved over a fifteen-year period, charting the evolution of a complex web of projects, papers, and relationships between them. We articulate the challenges of pursuing each activity as well as overarching challenges of balancing artistic and research interests, flexible management of relationships, and finally ethics.
Women, Bleeding, and Coronary Intervention

Bleeding initiates a cascade of events that increase morbidity and mortality among patients undergoing percutaneous coronary intervention (PCI). 1–5 Acute loss of blood impacts circulatory volume and can potentiate and perpetuate shock. In addition, bleeding leads to anemia and transfusion of blood products, which promote inflammation and untoward cardiovascular effects, especially in the setting of acute coronary syndrome.6–8 Finally, bleeding results in cessation of dual antiplatelet therapy, which increases risk of recurrent ischemic events such as stent thrombosis and myocardial infarction.9,10 Registries and randomized trials have shown the impact of bleeding on outcomes. Patient in the Global Registry of Acute Coronary Events were noted to have a 4.0% incidence of major bleeding across the spectrum of acute coronary syndrome (ACS). Furthermore, major bleeding was an independent predictor of in-hospital mortality (adjusted odds ratio, 1.64 [95% confidence interval, 1.18-2.28]). 11 Ndrepepa et al2 evaluated 4 randomized control trials of patients undergoing PCI and identified major bleeding as the strongest independent predictor of 1-year mortality. Similarly, Mehran et al12 performed a patient level pooled analysis of >17 000 patients in 3 ACS trials: the occurrence of a major bleed within 30 days of hospitalization was associated with a 4-fold higher risk of mortality at 1 year. Finally, in patients with ST segment elevation myocardial infarction enrolled in the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction trial, bleeding related to PCI was an independent predictor of mortality after 3 years of follow-up (hazard ratio, 2.80 [95% confidence interval, 1.89–4.16]). 13 Increased focus on the morbidity and mortality associated with PCI-related bleeding has led to pharmacological, procedural, and technological advances,14 which have resulted in improvement in post-PCI bleeding rates over the past decade (Figure 1). 15–18 The …
Efficient Bayesian Task-Level Transfer Learning

In this paper, we show how using the Dirichlet Process mixture model as a generative model of data sets provides a simple and effective method for transfer learning. In particular, we present a hierarchical extension of the classic Naive Bayes classifier that couples multiple Naive Bayes classifiers by placing a Dirichlet Process prior over their parameters and show how recent advances in approximate inference in the Dirichlet Process mixture model enable efficient inference. We evaluate the resulting model in a meeting domain, in which the system decides, based on a learned model of the user's behavior, whether to accept or reject the request on his or her behalf. The extended model outperforms the standard Naive Bayes model by using data from other users to influence its predictions.
Dynamically Combining Syntax and Semantics in Natural Language Processing

A controversy has existed over the interaction of syntax and semantics in natural language understanding systems. According to theories of integrated parsing, syntactic and semantic processing should take place simultaneously, with the parsing process driven by a single rule base which contains both syntactic and semantic knowledge. This is in sharp contrast to traditional linguistic approaches to language analysis, in which syntactic and semantic processing are performed separately from one another, driven by completely separate sets of syntactic and semantic rules. This paper presents an approach to natural language understanding which is a compromise between these two views. It is an integrated approach, in the sense that syntactic and semantic processing take place at the same time. However, unlike previous integrated systems, the approach described here uses largely separate bodies of syntactic and semantic knowledge, which are combined only at the time of processing.
Spontaneous Hepatic Rupture in Amyloidosis – Report of a Case

Abstract In systemic amyloidosis spontaneous rupture of the liver is a rare complication. Here we report on a patient with unrecognized systemic amyloidosis who presented to an outside hospital with unspecific abdominal pain. Under the signs of a hemorrhagic shock, distended abdomen and intraabdominal bleeding a laparotomy was performed. Due to uncontrollable hemorrhage of the ruptured right liver lobe a packing was performed. After being transferred to the reporting institution a CT scan was performed showing a grade IV laceration of the right liver. Therefore a transarterial embolization of the right hepatic artery was carried out. The following day an infection of the abdominal cavity and the abdominal wall with gas-producing bacteria was noticed and a relaparotomy, necrectomy and repacking due to diffuse bleeding were performed. The situation deteriorated and at the second relaparotomy the following day an almost completely necrotic liver was found. The patient deceased the following day. Life-threatening spontaneous liver rupture due to systemic amyloidosis might only successfully be cured by high urgency liver transplantation as presented in the literature. However, in two published cases interventional therapy by embolization of bleeding vessels has saved patients’ life.
Video traffic modeling over wireless networks

This paper studies the statistical model of MPEG video over wireless networks. A real-time MPEG video traffic workload was generated and transmitted over a wireless network. The model parameters of I, B and P frames were measured before and after wireless transmission. The results we got were very interesting. Intuitively, larger frames are more sensitive to network errors. The parameters associated with the statistical model should change after transmission. However, the results of the experiments showed that the statistical models of all I, B and P frames remain almost unchanged after transmission. We repeated the experiment under different wireless link layer error rates and got the same results. To simulate errors, we designed a controllable wireless link layer error model by modifying the WaveLAN device driver which is a Linux kernel module.
Improving the Detectability of Resistive Open Faults in Scan Cells

Recent studies have shown that new tests are required for the detection of a large percentage of scan cell internal open faults which are not detected by the existing tests. However, the additional coverage due to the new tests drops significantly when opens with moderate resistances are considered. In this paper we propose to augment earlier test methods to detect internal scan chain opens with a wider range of resistances. The newly proposed method includes application of tests at higher temperatures and modifications to an earlier proposed flush test. We also present an analysis to explain the additional coverage obtained by the proposed test methods.
CDA: Combinatorial Drug Discovery Using Transcriptional Response Modules

Background Anticancer therapies that target single signal transduction pathways often fail to prevent proliferation of cancer cells because of overlapping functions and cross-talk between different signaling pathways. Recent research has identified that balanced multi-component therapies might be more efficacious than highly specific single component therapies in certain cases. Ideally, synergistic combinations can provide 1) increased efficacy of the therapeutic effect 2) reduced toxicity as a result of decreased dosage providing equivalent or increased efficacy 3) the avoidance or delayed onset of drug resistance. Therefore, the interest in combinatorial drug discovery based on systems-oriented approaches has been increasing steadily in recent years. Methodology Here we describe the development of Combinatorial Drug Assembler (CDA), a genomics and bioinformatics system, whereby using gene expression profiling, multiple signaling pathways are targeted for combinatorial drug discovery. CDA performs expression pattern matching of signaling pathway components to compare genes expressed in an input cell line (or patient sample data), with expression patterns in cell lines treated with different small molecules. Then it detects best pattern matching combinatorial drug pairs across the input gene set-related signaling pathways to detect where gene expression patterns overlap and those predicted drug pairs could likely be applied as combination therapy. We carried out in vitro validations on non-small cell lung cancer cells and triple-negative breast cancer (TNBC) cells. We found two combinatorial drug pairs that showed synergistic effect on lung cancer cells. Furthermore, we also observed that halofantrine and vinblastine were synergistic on TNBC cells. Conclusions CDA provides a new way for rational drug combination. Together with phExplorer, CDA also provides functional insights into combinatorial drugs. CDA is freely available at http://cda.i-pharm.org.
Large-Scale, High-Throughput Validation of Short Hairpin RNA Sequences for RNA Interference

A method for high-throughput cloning and analysis of short hairpin RNAs (shRNAs) is described. Using this approach, 464 shRNAs against 116 different genes were screened for knockdown efficacy, enabling rapid identification of effective shRNAs against 74 genes. Statistical analysis of the effects of various criteria on the activity of the shRNAs confirmed that some of the rules thought to govern small interfering RNA (siRNA) activity also apply to shRNAs. These include moderate GC content, absence of internal hairpins, and asymmetric thermal stability. However, the authors did not find strong support for positionspecific rules. In addition, analysis of the data suggests that not all genes are equally susceptible to RNAinterference (RNAi).
A circulating current suppressing control in modular multilevel converter based unified power quality conditioner

In this paper, a circulating current suppressing control is proposed to suppress the circulating current in the modular multilevel converter based unified power quality conditioner (MMC-UPQC). In order to decrease the circulating current among the six phases of MMC-UPQC, which is resulted from the voltage difference of the six phases, an averaged phase voltage control is introduced in the UPQC control strategy. Operating principle of the proposed control is discussed. Simulation results are presented to verify the effectiveness of the proposed control method.
Comparison of speed of walking with and without visual distraction in subjects with Osteoarthritis of knee

Introduction: Knee osteoarthritis (OA) is a major public health problem. Knee OA leads to impaired balance and reduction in speed of relies on continuous visual processing to obstacles as one navigates through a visually defined environment. Objectives: The study aimed to compare the speed of walking with and without vis subjects with OA knee and with normal individuals. Material and methods: Fifteen subjects with OA knee and 15 without OA knee of same age and gender were selected. Subjects were selected according to inclusion and exclusion criteria. Experiment was carried out over straight path of 50 two consecutive days at preferred speed 3 times back and forth covering total distance of 300 Charts were shown on either of the two days. Subjects passed 12 t objects held by two assistants. Some objects were kept upright or inverted and subjects needed to reply by saying ‘yes’ or ‘no’. Charts of various colors were also shown and they were asked to identify them. The speed was not significance will be kept at 5%. Results: Wilcoxon test was used for within group analysis for speed of walking with and without distraction. Significant difference was seen for both subjects normal subjects (W=-3.266, p=0.001). Mann Whitney U test was used for between groups analysis. 2, Issue 6, June, 2015. 1* , Neeta Jayprakash Vyas Ahmedabad, Gujarat, India with and without visual distraction in subjects with Osteoarthritis of www.iaimjournal. com Accepted on: walking, which is accentuated under dual-task conditions. Walking m length and 2.5 m width. imes through charts of various ed. They also walked same distance without distraction. Level of with OA knee (W=ISSN: 2394-0026 (P) ISSN: 2394-0034 (O)
Improving statistical translation through editing

In this paper we introduce Linear B’s statistical machine translation system. We describe how Linear B’s phrase-based translation models are learned from a parallel corpus, and show how the quality of the translations produced by our system can be improved over time through editing. There are two levels at which our translations can be edited. The first is through a simple correction of the text that is produced by our system. The second is through a mechanism which allows an advanced user to examine the sentences that a particular translation was learned from. The learning process can be improved by correcting which phrases in the sentence should be considered translations of each other.
Efficient approximate nearest neighbor search by optimized residual vector quantization

In this paper, an optimized residual vector quantization-based approach is presented for approximate nearest neighbor search. The main contributions are as follows. Built on residual vector quantization (RVQ), a joint optimization process called enhanced RVQ (ERVQ) is introduced. Each stage-codebook is iteratively optimized by the others aiming at minimizing the overall quantization errors. Thus, an input vector is approximated by its quantization outputs more accurately and the precision of approximate nearest neighbor search is improved. To efficiently find nearest centroids when quantizing vectors, a non-linear vector quantization method is proposed. The vectors are embedded into 2-dimensional space where the lower bounds of Euclidean distances between the vectors and centroids are calculated. The lower bound is used to filter non-nearest centroids for the purpose of reducing computational costs. ERVQ is noticeably optimized in terms of time efficiency on quantizing vectors when combining with this method. Experimental results on SIFT and GIST datasets demonstrate that our approaches outperform the state-of-the-art methods in vector quantization and approximate nearest neighbor search.
Bioelectrical Impedance Methods for Noninvasive Health Monitoring: A Review

Under the alternating electrical excitation, biological tissues produce a complex electrical impedance which depends on tissue composition, structures, health status, and applied signal frequency, and hence the bioelectrical impedance methods can be utilized for noninvasive tissue characterization. As the impedance responses of these tissue parameters vary with frequencies of the applied signal, the impedance analysis conducted over a wide frequency band provides more information about the tissue interiors which help us to better understand the biological tissues anatomy, physiology, and pathology. Over past few decades, a number of impedance based noninvasive tissue characterization techniques such as bioelectrical impedance analysis (BIA), electrical impedance spectroscopy (EIS), electrical impedance plethysmography (IPG), impedance cardiography (ICG), and electrical impedance tomography (EIT) have been proposed and a lot of research works have been conducted on these methods for noninvasive tissue characterization and disease diagnosis. In this paper BIA, EIS, IPG, ICG, and EIT techniques and their applications in different fields have been reviewed and technical perspective of these impedance methods has been presented. The working principles, applications, merits, and demerits of these methods has been discussed in detail along with their other technical issues followed by present status and future trends.
New Scheme of Implementing Real-Time Linux

To well support the real-time requirement from applications, we enhance the real-time ability in Linux kernel through two new kernel mechanisms. Firstly, we present a new microsecond-level timer mechanism based on UTIME provided by Kurt-Linux, but different from it. The new timing implementation provides more flexible mechanism to support the different-grained timing requirement, as well as more flexible and preferential management of microsecond-level timers. Secondly, we present a new interrupt handler to reduce the kernel delay, which makes it possible scheduling interrupt handler with other processes under the system scheduler. Therefore, making interrupt routine under control is achieved. The experiments show that the improvements are distinct and significant.
Stability of Emission Properties of Silicon Nanostructures

The aging process of silicon nanostructures obtained by magnetron sputtering and electrochemical etching is investigated by photoluminescence and Raman scattering methods. It is shown that oxidation of silicon crystallites takes place in both types of structures and results in appearance of additional emission bands. However the degree of oxidation in etched structures exceeds significantly this value for sputtered samples. It is found that the intensity and spectral position of the emission band caused by exciton recombination in Si crystallites do not change practically during aging in sputtered structures in contrast to etched ones. It is shown that the oxidation of silicon amorphous phase occur during aging in sputtered structures.
A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

In the first reported positive result from a genome scan for non-insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of lambdas (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score </= -2) for lambdas >/= 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.
Human children rely more on social information than chimpanzees do

Human societies are characterized by more cultural diversity than chimpanzee communities. However, it is currently unclear what mechanism might be driving this difference. Because reliance on social information is a pivotal characteristic of culture, we investigated individual and social information reliance in children and chimpanzees. We repeatedly presented subjects with a reward-retrieval task on which they had collected conflicting individual and social information of equal accuracy in counterbalanced order. While both species relied mostly on their individual information, children but not chimpanzees searched for the reward at the socially demonstrated location more than at a random location. Moreover, only children used social information adaptively when individual knowledge on the location of the reward had not yet been obtained. Social information usage determines information transmission and in conjunction with mechanisms that create cultural variants, such as innovation, it facilitates diversity. Our results may help explain why humans are more culturally diversified than chimpanzees.