Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychopharmacology of topiramate: from epilepsy to bipolar disorder

Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially those displaying rapid-cycling and mixed states. This paper reviews the multiple mechanisms of action and the tolerability profile of TPM in the light of its therapeutic potential in affective disorders. Studies of TPM in bipolar disorder are evaluated, and the efficacy and tolerability issues as a mood stabilizing agent are discussed.
The inverse data space: examples and practical aspects

It has been proposed that in the case of strong multiple scattering, the data matrix P is replaced by its inverse P−1 before starting seismic processing. In the inverse data space, all surface-related multiples map onto the origin, whereas the inverse of the primaries map mostly at negative times. This interesting property opens up new ways to separate primaries from multiples and apply other preprocessing steps. In the previous chapter the concept was introduced and illustrated with two simple examples. In this chapter, the inversion of seismic data is demonstrated for a more complicated 2D example. Furthermore, a new strategy for obtaining the inverse of the data is developed, without involving explicit multi-dimensional inversion.
THE EFFECTS OF PRENATAL COCAINE EXPOSURE ON ATTENTION AND READING: A LONGITUDINAL STUDY

THE EFFECTS OF PRENATAL COCAINE EXPOSURE ON ATTENTION AND READING: A LONGITUDINAL STUDY By TAMARA DUCKWORTH WARNER A DISSERTATION PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY UNIVERSITY OF FLORIDA 2003
Maternal intensive care and near‐miss mortality in obstetrics

References 1 Khullar V, Damiano R, Toozs-Hobson P, Cardozo L. Prevalence of faecal incontinence among women with urinary incontinence. Br J Obstet Gynaecol1998; 105: 1211-1213. 2 MacArthur et al. Faecal incontinence after childbirth. Br J Obstet Gynaecol 1997; 104: 4650. 3 Kelleher Cl. A new questionnaire to assess the quality of life or urinary incontinent women. Br J Obstet Gynaecol 1997; 104: 1374-1379.
La actividad lógica de los bebés: un estudio diferencial

Este trabajo pretende, desde una perspectiva neuroconstructivista del desarrollo cognitivo, conocer y comparar la organizacion y contenido logico de la accion entre bebes con cursos de desarrollo alternativos: bebes tipicos (BT) y bebes con Sindrome de Down (BD). Desde el inicio de las relaciones del bebe con el medio hay una forma elemental de logica que se construye a traves de la accion organizada y significativa (logica en accion o protologica) que da lugar al origen del conocimiento tanto fisico como logico-matematico. Mediante la observacion sistematica se ha registrado la accion espontanea de n= 20 bebes, (n= 10 bebes tipicos, n= 10 bebes con Sindrome de Down), a una edad de desarrollo cognitivo equivalente a 1;3 anos (15 meses). Aplicando el analisis microgenetico y estadistico a los datos obtenidos, los resultados diferenciales muestran una menor organizacion y contenido logico de la accion en los BD, corroborando y ampliando investigaciones previas que ponen de manifiesto la necesidad de una intervencion temprana que optimice los recursos de desarrollo de los bebes.
The Utilization of Waste Marble Dust as a Cement Replacement in Air-Cured Mortar

The aim of this study is to assess the possibility of utilizing waste marble dust (WMD) as a partial cement substitution in air-cured mortar (ACM). Three different levels of cement replacement were analyzed: 5%, 10% and 15% by cement weight. The specimens were manufactured in a local laboratory at an air temperature of 22 ± 2 °C and a humidity equal to 20 ± 1%. The chemical and physical properties of ordinary Portland cement and WMD has been found to be the most crucial parameters. A variety of macroscopic tests, such as apparent density, porosity and compressive strength, were proposed in order to explain the effect of utilizing the WMD on the ACM. To confirm the results of the macroscopic properties, thorough microstructural analysis using scanning electron microscopy (SEM) was performed. The obtained results of this study indicate that replacing cement with WMD affects the physical and mechanical properties of air-cured mortar. The apparent density and compressive strength decrease while the porosity increases.
Reassessing Rhetorical Abstractions and Planning Mechanisms

The utihty of rhetorical abstractions and certain text planning mechanisms were assessed from the standpoint of accounting for how an explainer chooses and structures content under multiple perspectives to meet knowledge communication goals. This paper discusses ways in which they were found to be inadequate, argues for greater emphasis on an epistemological level of analysis, and proposes a mixed architecture matching computational mechanisms to the explanation planning subtasks they are suited for.
Requirement of bic/microRNA-155 for Normal Immune Function

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155–deficient CD4+ T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.
Leading Change in Public Organizations: A study about the role of leadership in the implementation of organizational change in a public sector context

markdownabstract__Abstract__ Als overheidsorganisaties veranderingen succesvol willen invoeren, doen ze dat het beste ‘bottom-up’. In zijn proefschrift ‘Leading Change in Public Organizations’ toont Joris van der Voet aan dat overheidsorganisaties geneigd zijn veranderingen in te voeren met een geplande aanpak, maar dat veranderingen die van onderaf worden ingevoerd op meer steun van de medewerkers kunnen rekenen. Verbind daarom ook lagere niveaus van leiderschap meer aan de strategische kwesties van overheidsorganisaties,. aldus Van der Voet. Van der Voet onderzocht op welke manier overheidsorganisaties veranderingen invoeren, wat de rol van leiderschap bij deze veranderingen is, en in hoeverre de gekozen veranderaanpak en het daarbij horende leiderschap resulteren in steun voor de organisatieverandering onder medewerkers. Hij deed vier studies binnen de gemeente Rotterdam, waar in de afgelopen jaren een aantal grootschalige veranderingen doorgevoerd in de gemeentelijke organisatie. Voor het onderzoek zijn interviews afgenomen met 46 huidige en voormalige managers, en hebben 1095 medewerkers een tweetal vragenlijsten ingevuld. De centrale conclusie van het promotieonderzoek is dat overheidsorganisaties voornamelijk proberen te veranderen met een geplande, top-down benadering. De typische kenmerken van overheidsorganisaties, zoals het politiek-bestuurlijke krachtenveld waarvan overheidsorganisaties onderdeel zijn en een hoge mate van bureaucratie, regels en procedures in de organisatie, dwingen deze veranderbenadering af. Hogere managers niet daardoor niet geneigd de touwtjes uit handen te geven, terwijl lagere managers en medewerkers weer niet gewend zijn de leiderschapsrol op zich te nemen. De onderzoeksresultaten laten tegelijkertijd zien dat veranderingen die worden ingevoerd met een emergente, bottom-up benadering zorgen voor meer steun voor de verandering onder medewerkers van de organisatie. Geplande verandering is dus de meest passende veranderaanpak voor publieke organisaties, terwijl verandering van onderaf zorgt voor meer steun onder medewerkers.
Relationships between Work‐related Factors and Disorders in the Neck‐shoulder and Low‐back Region among Female and Male Ambulance Personnel

Relationships between work‐related factors and disorders in the neck‐shoulder and low‐back region among female and male ambulance personnel: Ulrika Aasa, et al. Centre for Musculoskeletal Research, University of Gävle, Sweden—This cross‐sectional study on a random sample of 1,500 ambulance personnel investigated the relationships between self‐reported work‐related physical and psychosocial factors, worry about work conditions, and musculoskeletal disorders among female and male ambulance personnel. Three different outcomes, complaints, activity limitation, and sick leave, for the neck‐shoulder and low‐back region, respectively, were chosen. Among the female personnel, physical demands was significantly associated with activity limitation in the neck‐shoulder (OR 4.13) and low‐back region (OR 2.17), and psychological demands with neck‐shoulder (OR 2.37) and low‐back (OR 2.28) complaints. Among the male personnel, physical demands was significantly associated with low‐back complaints (OR 1.41) and activity limitation (OR 1.62). Psychological demands and lack of social support were significantly associated with neck‐shoulder complaints (OR 1.86 and OR 1.58, respectively) and activity limitation (OR 3.46 and OR 1.71) as well as activity limitation due to low‐back complaints (OR 2.22 and OR 1.63). Worry about work conditions was independently associated with activity limitation due to low‐back complaints among the female (OR 5.28), and to both neck‐shoulder and low‐back complaints (OR 1.79 and OR 2.04, respectively) and activity limitation (OR 2.32 and OR 1.95) among the male personnel. In conclusion, the association patterns between physical and psychological demands and MSDs suggest opportunities for intervention.
Long-Term Mortality in Patients With Stroke of Undetermined Etiology

Background and Purpose— The determination of stroke etiology is essential for planning treatment for stroke prevention. However, the etiology of stroke is undetermined in many patients. Methods— During a 10-year period, consecutive patients with acute ischemic stroke were enrolled. The stroke etiology was determined based on the Trial of ORG 10172 in Acute Stroke Treatment classification. Long-term mortality and causes of death were identified using death certificates. The standardized mortality ratio was calculated to compare the mortality in patients with stroke and that in the general Korean population. Results— In total, 3278 patients were enrolled and followed-up for a median of 3.4 years (interquartile range, 1.5–5.7). The stroke subtype was undetermined in 37% because of negative evaluation (21.2%), multiple causes (10.6%), and incomplete evaluation (4.8%). Poor functional outcome at 3 months (modified Rankin scale score >2) was more frequent in patients with an incomplete evaluation than in those with the other stroke subtypes (49.6% vs 24.5%; P<0.001). During follow-up, 781 patients (23.8%) died. The overall cumulative death rate was highest in patients with an incomplete evaluation (12.7% within 30 days, 25.5% within 1 year, and 35.7% within 3 years), followed by those with cardioembolism. Multivariate analysis after adjusting for covariates including initial stroke severity, the mortality of patients with an incomplete evaluation was second lowest after cardioembolism, whereas that in patients with a negative evaluation was low. Conclusions— Long-term mortality in patients with an incomplete evaluation was quite high. Etiologic work-up helps to better define the stroke subtype and determine the prognosis.
Robust Causality Characterization via Generalized Dispersion Relations

The self-consistency of frequency responses obtained via numerical simulations or measurements is of paramount importance in the analysis and design of linear systems. In particular, tabulated responses with flaws and causality violations have been demonstrated to be the root cause for numerical problems and unreliability in modeling and simulation tasks. In this work, we present the generalized dispersion relations as a robust and reliable tool for the causality characterization of frequency responses. Several applications are presented, including causality and passivity verification for tabulated data and causality-controlled interpolation schemes. Practical examples illustrate the excellent performance of the proposed techniques.
Linking Climate Suitability, Spread Rates and Host-Impact When Estimating the Potential Costs of Invasive Pests

Biosecurity agencies need robust bioeconomic tools to help inform policy and allocate scarce management resources. They need to estimate the potential for each invasive alien species (IAS) to create negative impacts, so that relative and absolute comparisons can be made. Using pine processionary moth (Thaumetopoea pityocampa sensu lato) as an example, these needs were met by combining species niche modelling, dispersal modelling, host impact and economic modelling. Within its native range (the Mediterranean Basin and adjacent areas), T. pityocampa causes significant defoliation of pines and serious urticating injuries to humans. Such severe impacts overseas have fuelled concerns about its potential impacts, should it be introduced to New Zealand. A stochastic bioeconomic model was used to estimate the impact of PPM invasion in terms of pine production value lost due to a hypothetical invasion of New Zealand by T. pityocampa. The bioeconomic model combines a semi-mechanistic niche model to develop a climate-related damage function, a climate-related forest growth model, and a stochastic spread model to estimate the present value (PV) of an invasion. Simulated invasions indicate that Thaumetopoea pityocampa could reduce New Zealand’s merchantable and total pine stem volume production by 30%, reducing forest production by between NZ$1,550 M to NZ$2,560 M if left untreated. Where T. pityocampa is controlled using aerial application of an insecticide, projected losses in PV were reduced, but still significant (NZ$30 M to NZ$2,210 M). The PV estimates were more sensitive to the efficacy of the spray program than the potential rate of spread of the moth. Our novel bioeconomic method provides a refined means of estimating potential impacts of invasive alien species, taking into account climatic effects on asset values, the potential for pest impacts, and pest spread rates.
Intrinsic Embedded Sensors for Polymeric Mechatronics: Flexure and Force Sensing

While polymeric fabrication processes, including recent advances in additive manufacturing, have revolutionized manufacturing, little work has been done on effective sensing elements compatible with and embedded within polymeric structures. In this paper, we describe the development and evaluation of two important sensing modalities for embedding in polymeric mechatronic and robotic mechanisms: multi-axis flexure joint angle sensing utilizing IR phototransistors, and a small (12 mm), three-axis force sensing via embedded silicon strain gages with similar performance characteristics as an equally sized metal element based sensor.
Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy

Significance This study demonstrates that the oncoembryonic surface antigen, receptor tyrosine kinase-like orphan receptor 1 (ROR1), is expressed on human ovarian cancer stem cells (CSCs), on which it seems to play a functional role in promoting migration/invasion or spheroid formation in vitro and tumor engraftment in immune-deficient mice. Treatment with a humanized mAb specific for ROR1 (UC-961) could inhibit the capacity of ovarian cancer cells to migrate, form spheroids, or engraft immune-deficient mice. Moreover, such treatment inhibited the growth of tumor xenografts, which in turn had a reduced capacity to engraft immune-deficient mice and were relatively depleted of cells with features of CSC, suggesting that treatment with UC-961 could impair CSC renewal. Collectively, these studies indicate that ovarian CSCs express ROR1, which may be targeted for anti-CSC therapy. Although initially responsive to chemotherapy, many patients with ovarian cancer subsequently develop relapsed and potentially fatal metastatic disease, which is thought to develop from cancer stem cells (CSCs) that are relatively resistant to conventional therapy. Here, we show that CSCs express a type I receptor tyrosine kinase-like orphan receptor (ROR1), which is expressed during embryogenesis and by many different cancers, but not normal postpartum tissues. Ovarian cancers with high levels of ROR1 had stem cell-like gene-expression signatures. Furthermore, patients with ovarian cancers with high levels of ROR1 had higher rates of relapse and a shorter median survival than patients with ovarian cancers that expressed low-to-negligible amounts of ROR1. We found that ROR1-positive (ROR1+) cells isolated from primary tumor-derived xenografts (PDXs) also expressed aldehyde dehydrogenase 1 (ALDH1) and had a greater capacity to form spheroids and to engraft immune-deficient mice than did ROR1-negative (ROR1Neg) ovarian cancer cells isolated from the same tumor population. Treatment with UC-961, an anti-ROR1 mAb, or shRNA silencing of ROR1 inhibited expression of the polycomb ring-finger oncogene, Bmi-1, and other genes associated with the epithelial–mesenchymal transition. Moreover, shRNA silencing of ROR1, depletion of ROR1+ cells, or treatment with UC-961 impaired the capacity of ovarian cancer cells to form spheroids or tumor xenografts. More importantly, treatment with anti-ROR1 affected the capacity of the xenograft to reseed a virgin mouse, indicating that targeting ROR1 may affect CSC self-renewal. Collectively, these studies indicate that ovarian CSCs express ROR1, which contributes to their capacity to form tumors, making ROR1 a potential target for the therapy of patients with ovarian cancer.
Superferric Magnet Option for the SSC

The basic design for the SSC started at Snowmass in the summer of 1982. The premise is that a superferric SSC has the potential to be simple, reliable, inexpensive and provide future flexibility. A concentrated effort began in March of 1984 when the Texas Accelerator Center was formed. The Texas Accelerator Center is a group of about 50 people divided into three areas of research, a calculations group working on beam dynamics, an R and D group working on superconducting magnets, and an R and D group working on new accelerator ideas including a proton linac and a plasma-laser accelerator. This paper will emphasize the work on the superferric magnet R and D.
What's being said near “Martha”? Exploring name entities in literary text collections

A common task in literary analysis is to study characters in a novel or collection. Automatic entity extraction, text analysis and effective user interfaces facilitate character analysis. Using our interface, called POSvis, the scholar uses word clouds and self-organizing graphs to review vocabulary, to filter by part of speech, and to explore the network of characters located near characters under review. Further, visualizations show word usages within an analysis window (i.e. a book chapter), which can be compared with a reference window (i.e. the whole book). We describe the interface and report on an early case study with a humanities scholar.
Addressing Hardware Security Challenges in Internet of Things: Recent Trends and Possible Solutions

Internet of Things (IoT) is an emerging technology where each and every 'thing' is possible to be connected through a network and also controllable from any remote station. Coming few years, IoT is going to be an unavoidable part of our daily lives. Every sector like manufacturing farms, traffic controls, real-time environment monitoring, security systems, health-care, e-agriculture etc. Is going to be governed by IoT as backbone. Ensuring security during this voluminous information exchange becomes a critical issue in this context. It applies equally to both device communication, control signals, and information exchange. In this paper an approach has been made to identify major security and privacy flaws existing in IoT enabled devices especially from hardware perspectives, and thereby to present possible solutions to existing challenges for conversion of 'Internet of Things' in 'Internet of Secure Things'.
Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin‐3 and supports cell migration

C4.4A is a member of the Ly6 family, with low homology to uPAR. It has been detected mainly on metastasizing carcinoma cells and proposed to be involved in wound healing. So far, C4.4A has been observed as an orphan receptor, and its functional activity has not been explored. Using recombinant rat C4.4A (rrC4.4A) made in a eukaryotic expression system, we demonstrate by immunohistology that C4.4A ligands are strongly expressed in tissues adjacent to squamous epithelia of, e.g., tongue and esophagus, the expression pattern partly overlapping with laminin (LN) and complementing the C4.4A expression that is found predominantly on the basal layers of squamous epithelium. ELISA screening of several components of the extracellular matrix revealed selective binding of rrC4.4A to LN1 and LN5 and that transfection of the BSp73AS tumor line with C4.4A cDNA (BSp73AS‐1B1) promoted LN1 and LN5 binding. Binding of BSp73AS‐1B1 to LN5 and, less markedly, LN1 induced spreading, lamellipodia formation and migration. C4.4A also associates with galectin‐3 in nontransformed tissues and tumor lines. There is evidence that the association of C4.4A with galectin‐3 influences LN adhesion. C4.4A was described originally as a metastasis‐associated molecule. Our findings that LN1 and LN5 are C4.4A ligands, that galectin‐3 associates with C4.4A and that C4.4A ligand binding confers a migratory phenotype are well in line with the supposed metastasis association. © 2005 Wiley‐Liss, Inc.
Direct Effects of Assets and Savings on the College Progress of Black Young Adults

Descriptive data indicate that 62% of White young adults between the ages of 17 and 23 years were on course (i.e., either in college or have graduated from college) in 2007, compared with only 37% of Black young adults. Given this, finding novel and promising ways to promote college progress among Black young adults, in particular, is a growing concern for policy makers. Controlling for a number of factors, the authors find that young adults who have school savings as adolescents are more likely to be on course than young adults who did not have school savings regardless of race. The authors conclude that policies that help parents and adolescents accumulate savings may be a simple and effective strategy for helping keep young adults “on course” in their college education, while taking on less debt.
Visual search applications for connecting published works to digital material

Visual search connects physical (offline) objects with (online) digital media. Using objects from the environment, like newspapers, magazines, books and posters, we can retrieve supplemental information from the online world. In this demonstration, we show a framework for delivering visual search services to users of mobile devices. We show how users can point a mobile device at any location in a document, magazine or book to view related, online material on the device. We describe client applications now being deployed for the iPhone and the server architecture used for recognition of scanned images.