Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring the angle of attack of beating insect wings: robust three-dimensional reconstruction from two-dimensional images

A robust technique for determining the angle of attack of insect wings from film of free flight has to date proved elusive. This report describes the development of two new methods ­ the Strips and Planes techniques ­ which were designed to overcome some of the limitations experienced in previous studies. The accuracy and robustness of these novel methods were tested extensively using simulated hawkmoth wing outlines generated for a realistic range of wing positions and torsion. The results were compared with those from two existing methods ­ the Symmetry and Landmarks procedures. The performance of the latter technique will be strongly species-dependent; it could not be successfully applied to hawkmoth flight because of practical difficulties in obtaining suitable landmarks. The Planes method was the least successful of the remaining techniques, especially during those phases of the wingbeat when the orientations of the two wings relative to the camera viewpoint were similar. The Symmetry and Strips methods were tested further to investigate the effects on their performance of introducing additional camber or wing motion asymmetry. The results showed clearly that the Strips method should be the technique of choice wherever the axis of wing torsion is close to the longitudinal axis of the wing. The procedure involves the experimenter matching a model wing divided into chordwise strips to the true wing outline digitized from high-speed film. The use of strips rather than the points digitized in previous studies meant that the analysis required only one wing outline to be digitized. Symmetry of motion between the left and right wings is not assumed. The implications of requiring human input to the Strips method, as opposed to the strictly numerical algorithms of the alternative techniques, are discussed. It is argued that the added flexibility that this provides in dealing with images which have typically been recorded in suboptimal conditions outweighs the introduction of an element of subjectivity. Additional observations arising from the use of the Strips analysis with high-speed video sequences of hawkmoth flight are given.
Polymorphism of Angiotensin-Converting Enzyme (rs4340) and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

Abstract Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme (ACE) gene and DN in Caucasians with type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, and 375 patients without clinical signs of DN. Genetic analysis was performed with either standard polymerase chain reaction (PCR) (for rs4340). Results were analyzed using the χ2 test and multivariate logistic regression analyses. We found no association between rs4340 and DN. Cystatin C was significantly higher in the DN+ group (p <0.001) than in the DN group. Cystatin C was a better marker for the estimation of renal function than estimated glomerular filtration rate (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ min. We concluded that there was no association between the rs4340 of the ACE gene and DN in Caucasian patients who have T2DM.
Lewy Body Pathology Involves Cutaneous Nerves

Involvement of the peripheral autonomic nervous system is a core feature of Lewy body (LB) diseases, including Parkinson disease (PD), PD with dementia, and dementia with LBs. To investigate the potential use of skin biopsy for the diagnosis of LB diseases, we assessed anti-phosphorylated &agr;-synuclein immunoreactivity in peripheral nerves in samples of skin from the abdominal wall and flexor surface of the upper arm in 279 prospectively studied consecutively autopsied patients whose data were registered at the Brain Bank for Aging Research between 2002 and 2005. Positive immunoreactivity was demonstrated in the unmyelinated fibers of the dermis in 20 of 85 patients with LB pathology in the CNS and the adrenal glands, the latter representing a substitute for peripheral autonomic nervous system sympathetic ganglia; no reactivity was seen in 194 patients without CNS LB pathology. In 142 retrospectively studied patients autopsied from 1995 onward who had subclinical or clinical LB disease, the sensitivity of the positive skin immunoreactivity was 70% in PD and PD with dementia and 40% in dementia with LBs. Skin immunoreactivity was absent in cases of multiple-system atrophy, progressive nuclear palsy, and corticobasal degeneration. We demonstrate for the first time that the skin is involved and may be a highly specific and useful biopsy site for the pathological diagnosis of LB diseases.
On the effect of overshooting as predicted by the modelling of the pre-main-sequence evolution of a 2 M⊙ star

We discuss the effects of convective overshooting in the pre-main-sequence (PMS) evolution of intermediate-mass stars, by analysing in detail the early evolution towards the main sequence of a 2 Mstellar model. These effects can be extremely important in the end of the PMS, when the abundances in CNO elements approach the equilibrium in the centre. We provide a possible physical explanation on why a moderate amount of overshooting produces, as the star approaches the zero-age main-sequence, an extra loop in the evolutionary tracks on the Hertzsprung-Russell diagram. An interesting feature is that there is a very well defined amount of overshooting (for a given stellar mass and chemical composition) beyond which a loop is produced. For smaller amounts of overshooting such a loop does not take place and the evolutionary tracks are similar to those found in the literature. The amount of overshooting needed to produce the loop decreases with stellar mass. We discuss the underlining physical reasons for the behaviour predicted by the evolution models and argue that it provides a crucial observational test for convective overshooting in the core of intermediate-mass stars.
Simultaneous cartoon and texture inpainting

Real images usually have two layers, namely, cartoons (the piecewise smooth part of the image) and textures (the oscillating pattern part of the image). Both these two layers have sparse approximations under some tight frame systems such as framelet, translation invariant wavelet, curvelet, and local DCTs. In this paper, we solve image inpainting problems by using two separate tight frame systems which can sparsely represent cartoons and textures respectively. Different from existing schemes in the literature which are either analysis-based or synthesis-based sparsity priors, our minimization formulation balances these two priors. We also derive iterative algorithms to find their solutions and prove their convergence. Numerical simulation examples are given to demonstrate the applicability and usefulness of our proposed algorithms in image inpainting.
180 degree hybrid (rat-race) junction on CMOS grade silicon with a polyimide interface layer

180-degree hybrid junctions can be used to equally divide power between two output ports with either a 0 or 180-degree phase difference. Alternatively, they can be used to combine signals from two sources and output a sum and difference signal. The main limitation of implementing these on CMOS grade silicon is the high loss associated with the substrate. In this paper, we present a low loss 180-degree hybrid junction on CMOS grade (15 /spl Omega/-cm) silicon with a polyimide interface layer for the first time. The divider utilizes Finite Ground Coplanar (FGC) line technology, and operates at a center frequency of 15 GHz.
Mining the Web's Hyperlinks for Recommendations

Human beings, not machines, are the ultimate experts for information retrieval tasks, including recommender systems. Consequently, computers are most useful when they combine information about people’s judgments. Collaborative filtering systems make use of this observation by having users explicitly rate items, such as Web pages, with the system making recommendations to other users based on overlapping areas of interest. A disadvantage of collaborative filtering, at least as currently implemented, is that it depends on users’ explicitly entering data, which can be inconvenient and timeconsuming. We describe a recommender system, which we call ParaSite, that works by mining publicly-available hyperlinks on the Web, producing results competitive with the best text-based system.
Transiently Secure Network Updates

Computer networks have become a critical infrastructure. Especially in shared environments such as datacenters it is important that a correct, consistent and secure network operation is guaranteed at any time, even during routing policy updates. In particular, at no point in time should it be possible for packets to bypass security critical waypoints~(such as a firewall or IDS) or to be forwarded along loops. This paper studies the problem of how to change routing policies in a transiently consistent manner. Transiently consistent network updates have been proposed as a fast and resource efficient alternative to per-packet consistent updates. Our main result is a negative one: we show that there are settings where the two basic properties waypoint enforcement and loop-freedom cannot be satisfied simultaneously. Even worse, we rigorously prove that deciding whether a waypoint enforcing, loop-free network update schedule exists is NP-hard. These results hold for both kinds of loop-freedom used in the literature: strong and relaxed loop-freedom. This paper also presents optimized, exact mixed integer programs to compute optimal update schedules. We report on extensive simulation results and initiate the discussion of scenarios where multiple waypoints need to be ensured (also known as service chains).
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

Traumatic brain injury (TBI) is an established risk factor for the early development of dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits neurofibrillary tangles comprised of aggregates of the protein tau. We have recently defined a brain-wide network of paravascular channels, termed the “glymphatic” pathway, along which CSF moves into and through the brain parenchyma, facilitating the clearance of interstitial solutes, including amyloid-β, from the brain. Here we demonstrate in mice that extracellular tau is cleared from the brain along these paravascular pathways. After TBI, glymphatic pathway function was reduced by ∼60%, with this impairment persisting for at least 1 month post injury. Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular interstitial solute clearance, exacerbated glymphatic pathway dysfunction after TBI and promoted the development of neurofibrillary pathology and neurodegeneration in the post-traumatic brain. These findings suggest that chronic impairment of glymphatic pathway function after TBI may be a key factor that renders the post-traumatic brain vulnerable to tau aggregation and the onset of neurodegeneration.
Cerebrovascular blood flow during the near syncopal phase of head-up tilt test: a comparative study in different types of neurally mediated syncope.

AIMS This study analyses the changes in cerebral blood flow (CBF) velocity occurring in the near syncopal phase of head-up tilt test (HUT) to determine whether their appearance during the premonitory symptoms permits the differentiation of the different types of haemodynamic response. METHODS AND RESULTS Six hundred and nineteen patients aged 35.9 +/- 16.4 with a prior history of syncope (55%) or presyncope (45%) were studied. Head-up tilt test was positive in 585 patients. The test was interrupted before syncope, once hypotension was evident and CBF changed. A vasovagal reaction (VVR) was observed in 245 patients. They had a 59% fall in diastolic CBF velocity, whereas systolic CBF velocity decreased by 12%. Postural orthostatic tachycardia syndrome (POTS) was observed in 82, systolic and diastolic CBF velocity decreased 44 and 60%, respectively. A similar response was observed in 258 patients with the orthostatic intolerance (OI) pattern. No significant changes were observed in the negative group. CONCLUSION Patients with VVR had changes in CBF velocity, which are different from those presented by patients with POTS and OI pattern. Cerebral blood flow monitoring is useful to increase the yield of HUT and may allow early interruption before syncope occurs, reducing patient discomfort.
Postnatal Pancreatic Islet β Cell Function and Insulin Sensitivity at Different Stages of Lifetime in Rats Born with Intrauterine Growth Retardation

Epidemiological studies have linked intrauterine growth retardation (IUGR) to the metabolic diseases, consisting of insulin resistance, type 2 diabetes, obesity and coronary artery disease, during adult life. To determine the internal relationship between IUGR and islet β cell function and insulin sensitivity, we established the IUGR model by maternal nutrition restriction during mid- to late-gestation. Glucose tolerance test and insulin tolerance test(ITT) in vivo and glucose stimulated insulin secretion(GSIS) test in vitro were performed at different stages in IUGR and normal groups. Body weight, pancreas weight and pancreas/body weight of IUGR rats were much lower than those in normal group before 3 weeks of age. While the growth of IUGR rats accelerated after 3 weeks, pancreas weight and pancreas/body weight remained lower till 15 weeks of age. In the newborns, the fasting glucose and insulin levels of IUGR rats were both lower than those of controls, whereas glucose levels at 120 and 180 min after glucose load were significantly higher in IUGR group. Between 3 and 15 weeks of age, both the fasting glucose and insulin levels were elevated and the glucose tolerance was impaired with time in IUGR rats. At age 15 weeks, the area under curve of insulin(AUCi) after glucose load in IUGR rats elevated markedly. Meanwhile, the stimulating index of islets in IUGR group during GSIS test at age 15 weeks was significantly lower than that of controls. ITT showed no significant difference in two groups before 7 weeks of age. However, in 15-week-old IUGR rats, there was a markedly blunted glycemic response to insulin load compared with normal group. These findings demonstrate that IUGR rats had both impaired pancreatic development and deteriorated glucose tolerance and insulin sensitivity, which would be the internal causes why they were prone to develop type 2 diabetes.
Psychogenic Tremor: A Video Guide to Its Distinguishing Features

Background Psychogenic tremor is the most common psychogenic movement disorder. It has characteristic clinical features that can help distinguish it from other tremor disorders. There is no diagnostic gold standard and the diagnosis is based primarily on clinical history and examination. Despite proposed diagnostic criteria, the diagnosis of psychogenic tremor can be challenging. While there are numerous studies evaluating psychogenic tremor in the literature, there are no publications that provide a video/visual guide that demonstrate the clinical characteristics of psychogenic tremor. Educating clinicians about psychogenic tremor will hopefully lead to earlier diagnosis and treatment. Methods We selected videos from the database at the Parkinson’s Disease Center and Movement Disorders Clinic at Baylor College of Medicine that illustrate classic findings supporting the diagnosis of psychogenic tremor. Results We include 10 clinical vignettes with accompanying videos that highlight characteristic clinical signs of psychogenic tremor including distractibility, variability, entrainability, suggestibility, and coherence. Discussion Psychogenic tremor should be considered in the differential diagnosis of patients presenting with tremor, particularly if it is of abrupt onset, intermittent, variable and not congruous with organic tremor. The diagnosis of psychogenic tremor, however, should not be simply based on exclusion of organic tremor, such as essential, parkinsonian, or cerebellar tremor, but on positive criteria demonstrating characteristic features. Early recognition and management are critical for good long-term outcome.
Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that is activated upon exposure to hypoxic stress. It modulates a number of cellular responses including proliferation, apoptosis, angiogenesis, and metabolism by activating a panel of target genes in response to hypoxia. The HIF-1 level is often upregulated in the hypoxic microenvironment of solid tumors, which contributes to cancer treatment failure. Here we report that silver nanoparticles (AgNPs), which are widely used as an antimicrobial agent, are an effective inhibitor of HIF-1. AgNPs inhibited the activation of a HIF-dependent reporter construct after the cells were exposed to hypoxic conditions or treated with cobalt chloride, a hypoxia mimetic agent. The AgNPs also interfered with the accumulation of HIF-1α protein and the induction of the endogenous HIF target genes, VEGF-A and GLUT1. Since both HIF-1 and vascular endothelial growth factor-A play an important role in angiogenesis, AgNPs also inhibited angiogenesis in vitro. Our data reveal a new mechanism of how AgNPs act on cellular function, that is, they disrupt HIF signaling pathway. This finding provides a novel insight into how AgNPs can inhibit cancer cell growth and angiogenesis.
High-volume haemofiltration with a new haemofiltration membrane having enhanced adsorption properties in septic pigs.

BACKGROUND High-volume haemofiltration (HVHF) has been suggested as an adjuvant treatment of septic shock due to its capacities to remove from blood both pro- and anti-inflammatory mediators involved in the sepsis syndrome. Adsorption properties of some haemofiltration membranes are also interesting with this indication because inflammatory mediators are caught in the membrane itself. The aim of this study was to determine the haemodynamic and immunological effects of a new haemofiltration membrane, which has enhanced adsorption properties due to a special surface treatment, allowing the adsorption of endotoxins. METHODS We compared this membrane to a standard haemofiltration membrane both in vitro and in 20 sepsis-induced pigs, randomized in two groups. One group was haemofiltered with the treated membrane and the other with the standard haemofiltration membrane during 6-h HVHF sessions. RESULTS At the end of the experiment, mean +/- SD crystalloids requirements (5937 +/- 1588 versus 7587 +/- 1456 ml, P = 0.026), colloids requirements (1437 +/- 320 versus 1912 +/- 538 ml, P = 0.027), lactic acidosis (pH = 7.20 +/- 0.11 versus 7.10 +/- 0.07, P = 0.026) and pulmonary arterial hypertension (MPAP = 24 +/- 7 versus 34 +/- 8 mmHg, P = 0.008) were less pronounced when HVHF was performed with the treated membrane. In addition, mean +/- SD endotoxins levels were lower in the treated membrane group after 1 hour of HVHF (1.91 +/- 1.19 versus 11.07 +/- 10.64 EU/ml, P = 0.035). Cytokines levels were not different between groups except for IL-1beta, which was slightly lower in the treated membrane group. CONCLUSIONS The use of a membrane with enhanced adsorption properties during a 6-h HVHF session in septic pigs improves haemodynamics compared to a standard haemofiltration membrane. These results are probably due to an efficient endotoxins and cytokines adsorption. A human study using this membrane is now necessary to confirm these results.
Queuing Network Performance Models for Virtual Graphic Display

: The performance of graphics display of virtual machine improves with the strong support from development of virtualization technology and computer hardware. However, in terms of graphical display mechanism there is a difference between the virtual environment and the traditional environment. So how to measure the performance of graphics display in virtualization environment effectively is especially attended.This paper analyzed the virtual display system in theory by models; compares theoretical data and measured data accessed by the virtual machine system performance evaluation; and finally verified the reasonableness of the model
Nondense orbits of flows on homogeneous spaces

Let $F$ be a nonquasi-unipotent one-parameter (cyclic) subgroup of a unimodular Lie group $G$, $\Gamma$ a discrete subgroup of $G$. We prove that for certain classes of subsets $Z$ of the homogeneous space $G/\Gamma$, the set of points in $G/\Gamma$ with $F$-orbits staying away from $Z$ has full Hausdorff dimension. From this we derive applications to geodesic flows on manifolds of constant negative curvature.
This is a repository copy of Heritability of Intraindividual Mean and Variability of Positive and Negative Affect : Genetic Analysis of Daily Affect Ratings Over a Month

Positive affect (e.g., attentiveness) and negative affect (e.g., upset) fluctuate over time. We examined genetic influences on interindividual differences in the day-to-day variability of affect (i.e., ups and downs) and in average affect over the duration of a month. Once a day, 17-year-old twins in the United Kingdom (N = 447) rated their positive and negative affect online. The mean and standard deviation of each individual’s daily ratings across the month were used as the measures of that individual’s average affect and variability of affect. Analyses revealed that the average of negative affect was significantly heritable (.53), but the average of positive affect was not; instead, the latter showed significant shared environmental influences (.42). Fluctuations across the month were significantly heritable for both negative affect (.54) and positive affect (.34). The findings support the two-factor theory of affect, which posits that positive affect is more situational and negative affect is more dispositional.
Ambient music experience in real and virtual worlds using audio similarity

Sound and, specifically, music is a medium that is used for a wide range of purposes in different situations in very different ways. Ways for music selection and consumption may range from completely passive, almost unnoticed perception of background sound environments to the very specific selection of a particular recording of a piece of music with a specific orchestra and conductor on a certain event. Different systems and interfaces exist for the broad range of needs in music consumption. Locating a particular recording is well supported by traditional search interfaces via metadata. Other interfaces support the creation of playlists via artist or album selection, up to more artistic installation of sound environments that users can navigate through. In this paper we will present a set of systems that support the creation of as well as the navigation in musical spaces, both in the real world as well as in virtual environments. We show some common principles and point out further directions for a more direct coupling of the various spaces and interaction methods.