Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient and clinician perspectives on the outpatient after-visit summary: a qualitative study to inform improvements in visit summary design

Objective: We explored patients’ and clinicians’ perspectives on electronic health record (EHR)–generated outpatient after-visit summaries (AVSs) to inform efforts to maximize the document’s utility. Materials and Methods: This qualitative study involved focus groups and semistructured interviews with patients (n = 39) and clinicians (n = 56) in adult primary care practices serving socioeconomically diverse communities in New York City; Long Island, New York; and Chicago, Illinois. Focus group and interview transcripts were coded and analyzed following standard qualitative methods. Results: Core themes included the use and purpose of the AVS, content modification and prioritization, formatting improvements, customization, privacy and accuracy concerns, and clinician workflow concerns. While most patients valued the document as a visit summary, others considered it a general summary of their health and health care issues, useful for sharing with family or clinicians even if they had access to their health records via web portals. Patients expressed a preference for the order of content items, and many wanted the reasons for medications and referrals stated. Additionally, some patients were confused by multiple medication lists indicating started, stopped, and modified medications, and a single “current” medication list was preferred by both patients and doctors. Concerns were raised about the risk of violating patient privacy and challenges to clinician workflow. Discussion: The AVS is valued by patients and clinicians. Both groups have identified numerous ways it can be improved, but also several obstacles to improvement and effective use. Conclusion: EHR vendors should work with stakeholder groups to improve the AVS to ensure that this important communication device achieves its patient-centered potential.
[The ophthalmologic signs in cerebellum tumor. Preliminary report].

Introduction The aim of the study was an analysis of ophthalmic symptoms coexisting with the tumour of the cerebellum. Material and methods The study included 14 patients in the age between 21–55 years old with the tumor of cerebellum, who were operated in the Neurosurgery Clinic of the Pomeranian Medical University in Szczecin. The comprehensive ophthalmic examination were performed before and after 5 days from surgery. The examinations included evaluation of: pupillary reactions, visual acuity, fundus ophthalmoscopy, intraocular pressures, eye motility, visual field, optometrical tests and visual manual localization test. Results The symptoms found before surgery of cerebellum tumors: diplopia (3 persons), early papilloedema (4 persons), nystagmus (2 persons), lack (5 persons) and weakened of convergence re􀏐lex (3 persons), latent strabismus (5 persons), manifest strabismus (3 persons). On the 5th day after the surgery were found: nystagmus (1 person), lack (5 persons) and weakened of the convergence re􀏐lex (3 persons). Visual manual localization was disparate depending on location of the tumor in the cerebellum; prevailed crossed and uncrossed localizations. Conclusions 1. The natural dynamic of the tumor and surgical damage to the posterior cranial cavity structures can be monitored by assessment of the condition of the organ sight. 2. It is recommended to make the visual manual localization tests such as exponent disorders of senso-motorical deviations, which may occur in the patients with the cerebellum tumor.
Low Power Operation of Temperature-Modulated Metal Oxide Semiconductor Gas Sensors

Mobile applications based on gas sensing present new opportunities for low-cost air quality monitoring, safety, and healthcare. Metal oxide semiconductor (MOX) gas sensors represent the most prominent technology for integration into portable devices, such as smartphones and wearables. Traditionally, MOX sensors have been continuously powered to increase the stability of the sensing layer. However, continuous power is not feasible in many battery-operated applications due to power consumption limitations or the intended intermittent device operation. This work benchmarks two low-power, duty-cycling, and on-demand modes against the continuous power one. The duty-cycling mode periodically turns the sensors on and off and represents a trade-off between power consumption and stability. On-demand operation achieves the lowest power consumption by powering the sensors only while taking a measurement. Twelve thermally modulated SB-500-12 (FIS Inc. Jacksonville, FL, USA) sensors were exposed to low concentrations of carbon monoxide (0–9 ppm) with environmental conditions, such as ambient humidity (15–75% relative humidity) and temperature (21–27 °C), varying within the indicated ranges. Partial Least Squares (PLS) models were built using calibration data, and the prediction error in external validation samples was evaluated during the two weeks following calibration. We found that on-demand operation produced a deformation of the sensor conductance patterns, which led to an increase in the prediction error by almost a factor of 5 as compared to continuous operation (2.2 versus 0.45 ppm). Applying a 10% duty-cycling operation of 10-min periods reduced this prediction error to a factor of 2 (0.9 versus 0.45 ppm). The proposed duty-cycling powering scheme saved up to 90% energy as compared to the continuous operating mode. This low-power mode may be advantageous for applications that do not require continuous and periodic measurements, and which can tolerate slightly higher prediction errors.
Developing an Unguided Internet-Delivered Intervention for Emotional Distress in Primary Care Patients: Applying Common Factor and Person-Based Approaches

Background Developing effective, unguided Internet interventions for mental health represents a challenge. Without structured human guidance, engagement with these interventions is often limited and the effectiveness reduced. If their effectiveness can be increased, they have great potential for broad, low-cost dissemination. Improving unguided Internet interventions for mental health requires a renewed focus on the proposed underlying mechanisms of symptom improvement and the involvement of target users from the outset. Objective The aim of our study was to develop an unguided e-mental health intervention for distress in primary care patients, drawing on meta-theory of psychotherapeutic change and utilizing the person-based approach (PBA) to guide iterative qualitative piloting with patients. Methods Common factors meta-theory informed the selection and structure of therapeutic content, enabling flexibility whilst retaining the proposed necessary ingredients for effectiveness. A logic model was designed outlining intervention components and proposed mechanisms underlying improvement. The PBA provided a framework for systematically incorporating target-user perspective into the intervention development. Primary care patients (N=20) who had consulted with emotional distress in the last 12 months took part in exploratory qualitative interviews, and a subsample (n=13) undertook think-aloud interviews with a prototype of the intervention. Results A flexible intervention was developed, to be used as and when patients need, diverting from a more traditional, linear approach. Based on the in-depth qualitative findings, disorder terms such as “depression” were avoided, and discussions of psychological symptoms were placed in the context of stressful life events. Think-aloud interviews showed that patients were positive about the design and structure of the intervention. On the basis of patient feedback, modifications were made to increase immediate access to all therapeutic techniques. Conclusions Detailing theoretical assumptions underlying Internet interventions for mental health, and integrating this approach with systematic in-depth qualitative research with target patients is important. These strategies may provide novel ways for addressing the challenges of unguided delivery. The resulting intervention, Healthy Paths, will be evaluated in primary care-based randomized controlled trials, and deployed as a massive open online intervention (MOOI).
Rice SUB1A constrains remodelling of the transcriptome and metabolome during submergence to facilitate post-submergence recovery.

The rice (Oryza sativa L.) ethylene-responsive transcription factor gene SUB1A-1 confers tolerance to prolonged, complete submergence by limiting underwater elongation growth. Upon desubmergence, SUB1A-1 genotypes rapidly recover photosynthetic function and recommence development towards flowering. The underpinnings of the transition from stress amelioration to the return to homeostasis are not well known. Here, transcriptomic and metabolomic analyses were conducted to identify mechanisms by which SUB1A improves physiological function over the 24 hr following a sublethal submergence event. Evaluation of near-isogenic genotypes after submergence and over a day of reaeration demonstrated that SUB1A transiently constrains the remodelling of cellular activities associated with growth. SUB1A influenced the abundance of ca. 1,400 transcripts and had a continued impact on metabolite content, particularly free amino acids, glucose, and sucrose, throughout the recovery period. SUB1A promoted recovery of metabolic homeostasis but had limited influence on mRNAs associated with growth processes and photosynthesis. The involvement of low energy sensing during submergence and recovery was supported by dynamics in trehalose-6-phosphate and mRNAs encoding key enzymes and signalling proteins, which were modulated by SUB1A. This study provides new evidence of convergent signalling pathways critical to the rapidly reversible management of carbon and nitrogen metabolism in submergence resilient rice.
Food insecurity, social networks and symptoms of depression among men and women in rural Uganda: a cross-sectional, population-based study

Abstract Objective To assess the association between food insecurity and depression symptom severity stratified by sex, and test for evidence of effect modification by social network characteristics. Design A population-based cross-sectional study. The nine-item Household Food Insecurity Access Scale captured food insecurity. Five name generator questions elicited network ties. A sixteen-item version of the Hopkins Symptom Checklist for Depression captured depression symptom severity. Linear regression was used to estimate the association between food insecurity and depression symptom severity while adjusting for potential confounders and to test for potential network moderators. Setting In-home survey interviews in south-western Uganda. Subjects All adult residents across eight rural villages; 96 % response rate (n 1669). Results Severe food insecurity was associated with greater depression symptom severity (b=0·4, 95 % CI 0·3, 0·5, P<0·001 for women; b=0·3, 95 % CI 0·2, 0·4, P<0·001 for men). There was no evidence of effect modification by social network factors for women. However, for men who are highly embedded within in their village social network, and (separately) for men who have few poor contacts in their personal network, the relationship between severe food insecurity and depression symptoms was stronger than for men on the periphery of their village social network, and for men with many poor personal network contacts, respectively. Conclusions In this population-based study from rural Uganda, food insecurity was associated with mental health for both men and women. Future research is needed on networks and food insecurity-related shame in relation to depression symptoms among food-insecure men.
All‐MOS implementation of RC networks for time‐controlled Gaussian spatial filtering

This paper addresses the design and VLSI implementation of MOS‐based RC networks capable of performing time‐controlled Gaussian filtering. In these networks, all the resistors are substituted one by one by a single MOS transistor biased in the ohmic region. The design of this elementary transistor is carefully realized according to the value of the ideal resistor to be emulated. For a prescribed signal range, the MOSFET in triode region delivers an interval of instantaneous resistance values. We demonstrate that, for the elementary 2‐node network, establishing the design equation at a particular point within this interval guarantees minimum error. This equation is then corroborated for networks of arbitrary size by analyzing them from a stochastic point of view. Following the design methodology proposed, the error committed by an MOS‐based grid when compared with its equivalent ideal RC network is, despite the intrinsic nonlinearities of the transistors, below 1% even under mismatch conditions of 10%. In terms of image processing, this error hardly affects the outcome, which is perceptually equivalent to that of the ideal network. These results, extracted from simulation, are verified in a prototype vision chip with QCIF resolution manufactured in the AMS 0. 35µm CMOS‐OPTO process. This prototype incorporates a focal‐plane MOS‐based RC network that performs fully programmable Gaussian filtering. Copyright © 2011 John Wiley & Sons, Ltd.
Characterizing Adult Sleep Behavior Over 20 Years—The Population-Based Doetinchem Cohort Study

Abstract Study Objectives: To describe sleep duration patterns of adults over a 20-year period; to compare sociodemographic, lifestyle, and health characteristics across these patterns; and to relate the patterns to sleep quality. Methods: The study population consisted of 3695 adults aged 20 to 59 years at baseline. Five measurements of self-reported sleep duration were used to compose seven patterns from 1987 to 2012: persistent short (≤6 hours), moderate (7–8 hours), or long (≥9 hours) sleep duration and several changing patterns (varying and became short, moderate, or long sleepers). Multinomial logistic regression analyses were used to compare characteristics across sleep duration patterns. Results: About 56% of the adults had persistent moderate sleep duration over 20 years. This group had a better sleep quality than the other groups. Of the adults who changed in their sleep duration (40%), 43% became a short sleeper. Sleep duration patterns that deviate from persistent moderate sleep duration were associated with physical inactivity during leisure time (odds ratios [ORs] and 95% confidence intervals [95% CIs] varied between 1.26 [1.04–1.53] and 1.58 [1.06–2.37]) and with poor self-rated health (ORs [95% CIs] varied between 1.50 [1.20–1.87] and 2.15 [1.48–3.12]). Conclusions: Nearly half of the adults did not have persistent moderate sleep duration over a 20-year period and more than one-sixth became short sleeper. This is reason for concern considering the adverse health status associated with short and long sleep duration. Leisure-time physical activity is a potential important target to prevent unfavorable changes in sleep duration over the life course.
Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1

Using structured illumination microscopy and photoconvertible tubulin in zebrafish photoreceptors, it is shown that microtubules move together during myoid elongation, a dark adaptive process in cone photoreceptors. Additionally, cytoplasmic dynein-1, localized at the base of the elongating myoid, mediates this unidirectional movement of microtubules.
Tick-Pathogen Ensembles: Do Molecular Interactions Lead Ecological Innovation?

UMR BIPAR, Animal Health Laboratory, ANSES, Institut National de la Recherche Agronomique, ENVA, Maisons Alfort, France, Department of Parasitology, Faculty of Science, University of South Bohemia, České Budějovice, Czechia, 3 Biology Center, Institute of Parasitology, Czech Academy of Sciences, České Budějovice, Czechia, 4 Faculty of Veterinary Medicine, University of Zaragoza, Zaragoza, Spain, 5 SaBio. Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain, Department of Veterinary Pathobiology, Center for Veterinary Health Sciences,
Towards a linguistically motivated model for selection in virtual reality

Swiftness and robustness of natural communication is tied to the redundancy and complementarity found in our multimodal communication. Swiftness and robustness of human-computer interaction (HCI) is also a key to the success of a virtual reality (VR) environment. The interpretation of multimodal interaction signals has therefore been considered a high goal in VR research, e.g. following the visions of Bolt's put-that-there in 1980 [1]. It is our impression that research on user interfaces for VR systems has been focused primarily on finding and evaluating technical solutions and thus followed a technology-oriented approach to HCI. In this article, we argue to complement this by a human-oriented approach based on the observation of human-human interaction. The aim is to find models of human-human interaction that can be used to create user interfaces that feel natural. As the field of Linguistics is dedicated to the observation and modeling of human-human communication, it could be worthwhile to approach natural user interfaces from a linguistic perspective. We expect at least two benefits from following this approach. First, the human-oriented approach substantiates our understanding of natural human interactions. Second, it brings about a new perspective by taking the interaction capabilities of a human addressee into account, which are not often explicitly considered or compared with that of the system. As a consequence of following both approaches to create user interfaces, we expect more general models of human interaction to emerge.
Multisensory object discovery via self-detection and artificial attention

We address self-perception and object discovery by integrating multimodal tactile, proprioceptive and visual cues. Considering sensory signals as the only way to obtain relevant information about the environment, we enable a humanoid robot to infer potential usable objects relating visual self-detection with tactile cues. Hierarchical Bayesian models are combined with signal processing and protoobject artificial attention to tackle the problem. Results show that the robot is able to: (1) discern between inbody and outbody sources without using markers or simplified segmentation; (2) accurately discover objects in the reaching space; and (3) discriminate real objects from visual artefacts, aiding scene understanding. Furthermore, this approach reveals the need for several layers of abstraction for achieving agency and causality due to the inherent ambiguity of the sensory cues.
Diethylstilbestrol regulates mouse gubernaculum testis cell proliferation via PLC‐Ca2+‐CREB pathway

Recent evidence suggested a positive correlation between environmental estrogens (EEs) and high incidence of abnormalities in male urogenital system, but the mechanism remains unclear. Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen that disrupts the morphology and proliferation of gubernaculum testis cells, but the underlying mechanism is unclear. In this study, mouse gubernaculum testis cells were pretreated with phospholipase C (PLC) inhibitor U‐73122 and then treated with DES. The results demonstrated that U‐73122 impaired DES‐evoked intracellular Ca2+ mobilization in gubernaculum testis cells and inhibited DES‐induced proliferation of gubernaculum testis cells. Mechanistically, we found that U‐73122 inhibited DES‐induced activation of cAMP‐response element binding protein (CREB) in gubernaculum testis cells. In conclusion, these data suggest that the effects of DES on mouse gubernaculum testis cells are mediated by PLC‐Ca2+‐CREB pathway.
The Development of Haptic Processing Skills From Childhood to Adulthood by Means of Two-Dimensional Materials

Research into haptic perception has mostly focused on 3-dimensional objects, and more needs to be known about the processing of 2-dimensional materials (e.g., raised dots and lines and raised-line shapes, patterns and pictures). This study examines the age-related changes in various skills related to the haptic exploration of 2-dimensional raised-line and dot materials and how these skills are related to haptic picture perception. Ninety-one participants, aged 4 years to adult, were asked to perform a series of haptic tasks that entailed (a) finding dots and following lines; (b) matching elements based on texture, shape, and size; (c) matching elements based on spatial location and orientation; (d) memorising sequences of dots and shapes; and (e) identifying complete and incomplete raised-line pictures. On all the tests, the results showed that scores improved with age. Shape discrimination scores accounted for variability in comprehension scores for outline pictures. We suggested that identifying tactile pictures by touch improved with age and mainly depended on the improvement of shape discrimination skills. Résumé Les recherches dans le domaine de la perception haptique se sont principalement concentrées sur les objets tridimensionnels. Il faudrait donc en connaître davantage sur le traitement de matériaux bidimensionnels (par ex., les points et lignes en relief, les formes aux contours en relief, les schémas et les images). La présente étude examine les changements liés à l’âge de différentes aptitudes impliquant l’exploration haptique de matériaux comportant des points et des contours en relief et comment ces aptitudes sont liées à la perception haptique des images. On a demandé à 91 participants, âgés entre 4 ans jusqu’à un âge adulte avancé, d’effectuer une série de tâches haptiques qui consistaient à (a) repérer les points et les lignes correspondantes; (b) agencer des éléments en se basant sur la texture, la forme et la taille; (c) agencer des éléments en se basant sur la situation et l’orientation spatiales; mémoriser des séquences de points et de formes; et (e) identifier des images à contours en relief complets et incomplets. Dans tous les tests, les résultats ont montré que les scores s’amélioraient avec l’âge. La variabilité des scores de compréhension au niveau des contours des images était attribuable aux scores de la discrimination des formes. Nous avons suggéré que l’identification d’images tactiles par le toucher s’améliorait avec l’âge et était principalement attribuable à l’amélioration des aptitudes en termes de discrimination des formes.
Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric Autotransporter Protein ApiA

ABSTRACT The Gram-negative bacterium Aggregatibacter actinomycetemcomitans is a causative agent of localized aggressive periodontitis. Critical to its infection process is the first and essential step of attachment, which is related to the coordinated functions of surface components comprised of proteins and extracellular polysaccharides. One such protein is the outer membrane trimeric autotransporter protein ApiA, a versatile virulence factor with numerous functions, including cell binding, invasion, serum resistance, autoaggregation, and induction of cytokine release. Here we report on the use of Escherichia coli strains expressing protein variants to define the separate functions ascribed to the N terminus and those related to the C terminus. Importantly, a hybrid protein that comprised the N terminus of trimeric ApiA and the β-barrel domain of monomeric autotransporter Aae was constructed, which allowed the expression of a monomer surface-exposed domain of ApiA. Functional and phenotypic analyses demonstrated that the C terminus of ApiA forms an independent domain that is crucial for general stability and trimer formation, which appears to be associated with autoaggregation, biofilm formation, and surface expression. Importantly, the results show that the monomeric form of the N-terminal passenger domain of ApiA, while surface exposed, is sufficient for binding to buccal epithelial cells; however, it is not sufficient to allow aggregation and biofilm formation, strengthening the importance of the role of trimerization in these phenotypes.