Miracle-dz/UniFAR-FTUs huggingface dataset:
Watermarking techniques for intellectual property protection

Digital system designs are the product of valuable effort and know-how. Their embodiments, from software and HDL program down to device-level netlist and mask data, represent carefully guarded intellectual property (IP). Hence, design methodologies based on IP reuse require new mechanisms to protect the rights of IP producers and owners. This paper establishes principles of watermarking-based IP protection, where a watermark is a mechanism for identification that is (i) nearly invisible to human and machine inspection, (ii) difficult to remove, and (iii) permanently embedded as an integral part of the design. We survey related work in cryptography and design methodology, then develop desiderata, metrics and example approaches-centering on constraint-based techniques-for watermarking at various stages of the VLSI design process.
Modified Polysaccharides as Fast Disintegrating Excipients for Orodispersible Tablets of Roxithromycin

The purpose of this study was to develop a dosage form that was easy to administer and provides rapid release of the drug roxithromycin, using modified polysaccharides as rapidly disintegrating excipients. Modified polysaccharides co grinded treated agar (C-TAG) and co grinded treated guar gum (C-TGG) were prepared by subjecting pure polysaccharides namely agar and guar gum respectively to sequential processes of wetting, drying and co grinding with mannitol (1:1). The modified polysaccharides were characterized by Scanning Electron Microscopy and Diffuse Reflectance Spectroscopy and evaluated for particle size distribution, derived properties, swelling index and biodegradability. Optimization studies based on 22 factorial designs, with friability and disintegration time as response parameters were used to formulate orodispersible tablets of roxithromycin and evaluated for wetting time, water absorption ratio and in vitro drug release at salivary pH 6.4 and physiological pH 7.4. Results indicated that lower levels of modified polysaccharides namely C-TAG in F3 and C-TGG in F7 and higher levels of microcrystalline cellulose, exhibited least disintegration times without friability concerns. In vitro release of optimized formulations F3 and F7, both at salivary pH and physiological pH was found to be more than 90% within 30 min as compared to 27.82% at the same time point of conventional formulation. Stability studies carried out as per ICH Q1A guidelines suggested the formulations to be stable for a period of 6 months. Thus the approach of using modified polysaccharides as fast disintegrating excipient can be used to formulate a stable orodispersible formulation.
A Multi-Differential Neuromorphic Approach to Motion Detection

This paper presents a multi-differential neuromorphic approach to motion detection. The model is based evidence for a differential operators interpretation of the properties of the cortical motion pathway. We discuss how this strategy, which provides a robust measure of speed for a range of types of image motion using a single computational mechanism, forms a useful framework in which to develop future neuromorphic motion systems. We also discuss both our approaches to developing computational motion models, and constraints in the design strategy for transferring motion models to other domains of early visual processing.
Age effects on Norway spruce (Picea abies) susceptibility to ozone uptake: a novel approach relating stress avoidance to defense.

Cumulative ozone (O3) uptake and O3 flux were related to physiological, morphological and biochemical characteristics of Norway spruce (Picea abies (L.) Karst. ) trees of different ages. Under ambient CO2 conditions, photosynthetic capacity (Amax) declined in mature trees when cumulative O3 uptake into needles, which provides a measure of effective O3 dose, exceeded 21 mmol m-2 of total needle surface area. A comparable decline in Amax of seedlings occurred when cumulative O(3) uptake was only 4.5 mmol m-2. The threshold O3 flux causing a significant decline in Amax ranged between 2.14 and 2.45 nmol m-2 s-1 in mature trees and seedlings subjected to exposure periods of > or = 70 and > or = 23 days, respectively. The greater O3 sensitivity of young trees compared with mature trees was associated with needle morphology. Biomass of a 100-needle sample increased significantly with tree age, whereas a negative correlation was found for specific leaf area, these changes parallel those observed during differentiation from shade-type to sun-type needles with tree ontogeny. Age-dependent changes in leaf morphology were related to changes in detoxification capacity, with area-based concentrations of ascorbate increasing during tree ontogeny. These findings indicate that the extent of O3-induced injury is related to the ratio of potentially available antioxidants to O3 influx. Because this ratio, when calculated for ascorbate, increased with tree age, we conclude that the ratio may serve as an empirical basis for characterizing age-related differences in tree responses to O3.
Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3

ABSTRACT Dok-3 is a Dok-related adaptor expressed in B cells and macrophages. Previously, we reported that Dok-3 is an inhibitor of B-cell activation in A20 B cells and that it associates with SHIP-1, a 5′ inositol-specific lipid phosphatase, as well as Csk, a negative regulator of Src kinases. Here, we demonstrate that Dok-3 suppresses B-cell activation by way of its interaction with SHIP-1, rather than Csk. Our biochemical analyses showed that the Dok-3-SHIP-1 complex acts by selectively inhibiting the B-cell receptor (BCR)-evoked activation of the Jun N-terminal protein kinase (JNK) cascade without affecting overall protein tyrosine phosphorylation or activation of previously described SHIP-1 targets like Btk and Akt/PKB. Studies of B cells derived from SHIP-1-deficient mice showed that BCR-triggered activation of JNK is enhanced in the absence of SHIP-1, implying that the Dok-3-SHIP-1 complex (or a related mechanism) is a physiological negative regulator of the JNK cascade in normal B cells. Together, these data elucidate the mechanism by which Dok-3 inhibits B-cell activation. Furthermore, they provide evidence that SHIP-1 can be a negative regulator of JNK signaling in B cells.
To Click or not to Click? The Role of Contextualized and User-Centric Web Snippets

searching the web, it is often possible that there are too many results available for ambiguous queries. Text snippets, ex- tracted from the retrieved pages, are an indicator of the pages' usefulness to the query intention and can be used to focus the scope of search results. In this paper, we propose a novel method for automatically extracting web page snippets that are highly relevant to the query intention and expressive of the pages' entire content. We show that the usage of semantics, as a basis for fo- cused retrieval, produces high quality text snippet suggestions. The snippets delivered by our method are significantly better in terms of retrieval performance compared to those derived using the pages' statistical content. Furthermore, our study suggests that semantically-driven snippet generation can also be used to aug- ment traditional passage retrieval algorithms based on word over- lap or statistical weights, since they typically differ in coverage and produce different results. User clicks on the query relevant snippets can be used to refine the query results and promote the most comprehensive among the relevant documents.
Mobile Augmented Reality for Retail Environments

We present a mobile handheld augmented reality system for presenting product information to a consumer. The system allows the user to view a three-dimensional model of product package contents with a mobile phone. The model is displayed over the product packaging, allowing the user to view the package contents without opening the package. Additional digital content related to the product can also be shown. This includes product videos, web-based content and product information from an external data base. The system demonstrates context-awareness by modifying the displayed content according to the location of the user; different content can be shown in a store and at home. In this paper, we describe the overall functionality, interaction and implementation of the system. Author
Quality of Diabetes Care: The Challenges of an Increasing Epidemic in Mexico. Results from Two National Health Surveys (2006 and 2012)

Background The quality of diabetes care remains suboptimal according to numerous studies assessing the achievement of quality indicators for diabetes care in various healthcare settings. We report about global and specific quality indicators for diabetes care and their association to glycemic control at the population level in two national health surveys in Mexico. Methods We conducted a cross-sectional analysis of the 2006 and 2012 National Health Surveys in Mexico. We examined quality of care for 2,965 and 4,483 adults (≥ 20 years) with diagnosed type 2 diabetes using fourteen simple and two composite indicators derived from self-reported information. In a subsample for both surveys, glycated hemoglobin (HbA1c) was measured at the time of the interview. We obtained survey weight-adjusted estimators using multiple regression models (logistic and linear) with combined data files, including survey year as covariate to assess change. Results Global quality of care in 2012 was 40.8%, with a relative improvement of 11.7% between 2006 and 2012. Detections of cardiovascular disease risk factors (dyslipidemia and hypertension) were the indicators with the highest improvement, while non-pharmaceutical treatment and diabetic foot exams showed minor changes. We found a significant association between the quality of the process of diabetes care and glycemic control (OR 2.53, 95% CI 1.63-3.94). Age more than 65 years old, the type of health subsystem, gender (males), and high socio-economic status were also significantly associated to glycemic control. Conclusions Quality diabetes care and glycemic control improved and are significantly associated. However, according to international standards, the current situation remains suboptimal. A more holistic approach is needed, with an emphasis on improving quality in outpatient care.
Comparison of geometric regularization methods for 2D myocardial strain estimation in the mouse

Myocardial strain quantification in the mouse based on 2D speckle tracking using real time ultrasound data sets is feasible but still challenging. This is due to the low frame rate (about 300 Hz) in comparison with the high heart rate (500-700 bpm) which causes significant de-correlation between successive frames. The aim of this work was twofold: first, to analyze which motion estimator performs best in the context of real time cardiac murine data sets and second, to study the effect of different geometric regularizers on the initial motion assessment using a simulated mouse heart. More stable strain estimates were obtained making use of normalized cross-correlation followed by spatially limiting the curvature of the motion field.
Relapse Model among Iranian Drug Users: A Qualitative Study

Background: Relapse is a common problem in drug user’s rehabilitation program and reported in all over the country. An in-depth study on patients’ experiences can be used for exploring the relapse process among drug users. Therefore, this study suggests a model for relapse process among Iranian drug users. Methods: In this qualitative study with grounded theory approach, 22 participants with rich information about the phenomenon under the study were selected using purposive, snowball and theoretical sampling methods. After obtaining the informed consent, data were collected based on face-to-face, in-depth, semi-structured interviews. All interviews were analyzed in three stages of axial, selective and open coding methods. Results: Nine main categories emerged, including avoiding of drugs, concerns about being accepted, family atmosphere, social conditions, mental challenge, self-management, self-deception, use and remorse and a main category, feeling of loss as the core variable. Mental challenge has two subcategories, evoking pleasure and craving. Relapse model is a dynamic and systematic process including from cycles of drug avoidance to remorse with a core variable as feeling of loss. Conclusion: Relapse process is a dynamic and systematic process that needs an effective control. Determining a relapse model as a clear process could be helpful in clinical sessions. Results of this research have depicted relapse process among Iranian drugs user by conceptual model.
Sub-aperture Behavior of SAR Signatures of Ships

The SAR signatures of ships in separate sub-apertures are investigated in two RADARSAT images. It is found that in most cases there is a low correlation between the sub-apertures. Several alternative combinations of three sub-apertures, other than the usual multi-look average, are investigated for their ship detection performance on an image with medium sea state. At least in that case, none of the alternative combinations (including cross-coherence) outperforms the classical multi-look approach. The differences between the polarization channels in ENVISAT ASAR AP mode may be partly due to sub-aperture effects.
New Insights into the Understanding of Gastrointestinal Dysmotility

Our understanding of the physiology of digestion, absorption, secretion, and motility in the gastrointestinal tract has improved immensely. Today it is well established that the gross functions of the gastrointestinal tract depend on the coordination between the muscles, nerves and hormones. The enteric nervous system (ENS) is involved in most of the physiological and pathophysiological processes in the gastrointestinal tract. Therefore, clinical and experimental studies on the ENS provide the basis for a better understanding of the mechanisms involved in gastrointestinal disorders and promote the development of therapeutic options. This review outlines some of the current views on the role of the ENS and its related hormones in gastrointestinal motility.
Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries.

BACKGROUND Rho-associated kinase (ROCK), an effector of small GTPase Rho, regulates vascular tone via a calcium sensitization mechanism and plays a key role in the pathogenesis of hypertension. However, its role in vascular growth remains unclear. METHODS AND RESULTS Y-27632, a specific ROCK inhibitor, and the overexpression of dominant-negative ROCK suppressed the mitogen-induced DNA synthesis of cultured vascular smooth muscle cells (VSMCs), which indicates the essential role of ROCK in the control of VSMC proliferation in vitro. Y-27632 also suppressed the chemotaxis of VSMCs. Male Wistar rats were systemically given Y-27632 (35 to 70 mg. kg(-1). day(-1)) through an intraperitoneal infusion. The neointimal formation of balloon-injured carotid arteries was significantly suppressed in Y-27632-treated rats (intima/media ratio, 0.22+/-0.02) compared with vehicle-treated rats (intima/media ratio, 0.92+/-0.21) or hydralazine-treated rats with a similar blood pressure decrease (intima/media ratio, 1.03+/-0.15). The phosphorylation of myosin phosphatase and myosin light chain was elevated in injured arteries in a Y-27632-sensitive manner, indicating the augmentation of ROCK activity in neointimal formation. The downregulation of the cyclin-dependent kinase inhibitor p27(kip1) in injured vessels was reversed by Y-27632 treatment, reflecting the antiproliferative effect of ROCK inhibition in vivo. CONCLUSIONS We conclude that ROCK plays a key role in the process of neointimal formation after balloon injury. Thus, the inhibition of ROCK may be a potential therapeutic strategy for treating vascular proliferative disorders and hypertension.
Optimization of alternating TR‐SSFP for fat‐suppression in abdominal images at 3T

Magnetic resonance imaging is widely used in the work‐up and monitoring of patients with Crohn's disease. Balanced steady‐state free precession sequences are an important part of the imaging protocol and until now primarily 1.5T scanners have been used in daily clinical practice. This is largely because running balanced steady‐state free precession sequences in 3T magnets has technical problems related to increased B0 inhomogeneity and specific absorption rate (SAR) deposition. A modified form of alternating repetition time steady‐state free precession sequence is presented to acquire 3D‐isotropic abdominal images with fat‐suppression at 3T within a breath‐hold. The modifications include an adjusted radiofrequency pulse shape, suitable phase‐cycling scheme and TR1/TR2 ratio. Results show that the proposed sequence is successful in obtaining high contrast 3D‐isotropic abdominal images within a breath‐hold. Furthermore, the proposed methodology is easy to implement in a clinical setting and does not require any postprocessing steps. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
DVS for on-chip bus designs based on timing error correction

On-chip buses are typically designed to meet performance constraints for worst-case conditions, including process corner, temperature, IR-drop, and neighboring net switching pattern. This can result in significant performance slack at more typical operating conditions. We propose a dynamic voltage scaling (DVS) technique for buses, based on a double sampling latch which can detect and correct for delay errors without the need for retransmission. The proposed approach recovers the available slack at non-worst-case operating points through more aggressive voltage scaling and track changing conditions by monitoring the error recovery rate. Voltage margins needed in traditional designs to accommodate worst-case performance conditions are therefore eliminated, resulting in a significant improvement in energy efficiency. The approach was implemented for a 6 mm memory read bus operating at 1.5 GHz (0.13 /spl mu/m technology node) and was simulated for a number of benchmark programs. Even at the worst-case process and environment conditions, energy gains of up to 17% are achieved, with error recovery rates under 2.3%. At more typical process and environment conditions, energy gains range from 35% to 45%, with a performance degradation under 2%. An analysis of optimum interconnect architectures for maximizing energy gains with this approach shows that the proposed approach performs well with technology scaling.
Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer.

PURPOSE The phase III, randomized, placebo-controlled Sequential Tarceva in Unresectable NSCLC (SATURN; BO18192) study found that erlotinib maintenance therapy extended progression-free survival (PFS) and overall survival in patients with advanced non-small-cell lung cancer (NSCLC) who had nonprogressive disease following first-line platinum-doublet chemotherapy. This study included prospective analysis of the prognostic and predictive value of several biomarkers. PATIENTS AND METHODS Mandatory diagnostic tumor specimens were collected before initiating first-line chemotherapy and were tested for epidermal growth factor receptor (EGFR) protein expression by using immunohistochemistry (IHC), EGFR gene copy number by using fluorescent in situ hybridization (FISH), and EGFR and KRAS mutations by using DNA sequencing. An EGFR CA simple sequence repeat in intron 1 (CA-SSR1) polymorphism was evaluated in blood. RESULTS All 889 randomly assigned patients provided tumor samples. EGFR IHC, EGFR FISH, KRAS mutation, and EGFR CA-SSR1 repeat length status were not predictive for erlotinib efficacy. A profound predictive effect on PFS of erlotinib relative to placebo was observed in the EGFR mutation-positive subgroup (hazard ratio [HR], 0.10; P < .001). Significant PFS benefits were also observed with erlotinib in the wild-type EGFR subgroup (HR, 0.78; P = .0185). KRAS mutation status was a significant negative prognostic factor for PFS. CONCLUSION This large prospective biomarker study found that patients with activating EGFR mutations derive the greatest PFS benefit from erlotinib maintenance therapy. No other biomarkers were predictive for outcomes with erlotinib, although the study was not powered for clinical outcomes in biomarker subgroups other than EGFR IHC-positive [corrected]. KRAS mutations were prognostic for reduced PFS. The study demonstrated the feasibility of prospective tissue collection for biomarker analyses in NSCLC.
Privacy Preserved Rule-Based Risk Analysis through Secure Multi-party Computation

Network systems are becoming the core components of technical information infrastructures. The protection of network systems from malicious attacks is an urgent priority in our society. However, considering that all security threats are very complicated, easily missed, and error-prone, dealing with network vulnerabilities has brought about enormous challenges to network management. Therefore, one reasonable solution for a risk analysis is delegating an analysis of a network system to third parties that have more professional knowledge regarding a risk analysis. Highly confidential data such as the network configuration and vulnerabilities, as well as each hosts, are needed when delegating a risk analysis to a third party. Such confidential data may cause information leakage if no protection is provided. In this paper, we proposed a risk analysis system based on a rule-based risk analysis method. The prototype system was developed using Fairplay MP, a secure multi-party computation system, and was evaluated for a small network environment.
Amphetamine and cocaine induce different patterns of c‐fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context

In the dorsal striatum, there are two major populations of medium spiny projection neurons. One population is positive for dynorphin mRNA (DYN+), and these cells project preferentially to the substantia nigra, forming the so‐called ‘direct pathway’. A second population is positive for enkephalin mRNA (ENK+), and these cells influence the substantia nigra indirectly, via the globus pallidus and subthalamic nucleus. Psychostimulant drugs, such as amphetamine and cocaine, are reported to induce immediate early genes (IEGs) in only one subpopulation of dorsal striatal projection neurons, DYN+ cells. However, this apparent selectivity appears to be a function of environmental context. We found that when given in the animal's home cage, amphetamine and cocaine increased expression of the IEG, c‐fos, almost exclusively in DYN+ cells. However, when given in a novel environment, amphetamine and cocaine increased c‐fos mRNA in both DYN+ and ENK+ cells. Furthermore, amphetamine and cocaine increased c‐fos mRNA expression in the subthalamic nucleus when administered in the novel environment, but not when given at home. We conclude that the neural circuitry engaged by psychostimulant drugs, and their ability to induce specific patterns of gene expression, are determined by the environmental context in which they are experienced. This may be related to the ability of environmental novelty to facilitate psychostimulant drug‐induced neuroplasticity.