Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulatory Effect of Acupuncture at Waiguan (TE5) on the Functional Connectivity of the Central Nervous System of Patients with Ischemic Stroke in the Left Basal Ganglia

Objective To study the influence of acupuncture at Waiguan (TE5) on the functional connectivity of the central nervous system of patients with ischemic stroke. Methods Twenty-four patients with ischemic stroke in the left basal ganglia were randomized based on gender to receive TE5 acupuncture (n = 12) or nonacupoint acupuncture (n = 12). Each group underwent sham acupuncture and then verum acupuncture while being scanned with functional magnetic resonance imaging. Six regions of interest (ROI) were defined, including bilateral motor, somatosensory, and bilateral basal ganglia areas. The functional connectivity between these ROIs and all voxels of the brain was analyzed in Analysis of Functional NeuroImages(AFNI) to explore the differences between verum acupuncture and sham acupuncture at TE5 and between TE5 acupuncture and nonacupoint acupuncture. The participants were blinded to the allocation. Result The effect of acupuncture on six seed-associated networks was explored. The result demonstrated that acupuncture at Waiguan (TE5) can regulate the sensorimotor network of the ipsilesional hemisphere, stimulate the contralesional sensorimotor network, increase cooperation of bilateral sensorimotor networks, and change the synchronization between the cerebellum and cerebrum. Furthermore, a lot of differences of effect existed between verum acupuncture and sham acupuncture at TE5, but there was little difference between TE5 acupuncture and nonacupoint acupuncture. Conclusion The modulation of synchronizations between different regions within different brain networks might be the mechanism of acupuncture at Waiguan (TE5). Stimulation of the contralesional sensorimotor network and increase of cooperation of bilateral hemispheres imply a compensatory effect of the intact hemisphere, whereas changes in synchronization might influence the sensorimotor function of the affected side of the body. Trial Registration Chinese Clinical Trial Registry ChiCTR-ONRC-08000255
Optical Properties of Plasmonic Ag/Ni Square Nanostructures

In this work, optical reflectivity and transmission measurements have been carried out in order to investigate the plasmonic properties of samples with periodic nanostructures. The main results for two lattices with square islands and with square holes respectively will be presented and analyzed in order to understand the optical features and how the geometry are related to the plasmonic excitations of the structures. The aim of these measurements is to shed light on the role of material properties of Ag as well as to understand how the plasmonic responses are affected when altering the incident angle and wavelength of the incident light. A large emphasis has been made on the difference between plasmonic excitation from s-polarized versus p-polarized light interacting with the samples. It has been shown that it is possible to manipulate and govern the plasmonic responses of periodic, square nanostructures by this method and that both pand s-polarized light are capable of exciting surface plasmons, however along different directions in the surface of the nanostructure.
A rotor position estimation method based on fuzzy PI for SPMSM sensorless control

This paper focuses on the high frequency current injection method for sensorless control of surface mounted permanent magnet synchronous machines (SPMSM) at low speed. In sensorless control of injection method, a PI close loop is needed to estimate the rotor position. However, constant PI parameters are unable to achieve optimal control effect in both process of dynamic and steady-state. In this paper, fuzzy PI position observer is proposed to realize the real-time parameter adjustment. Simulation and experimental results show that fuzzy PI position observer improves the precision of rotor position estimation and ensures the quickness of the rotor position estimation simultaneously.
Predictors of Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage

Background— Clinical and radiologic predictors of cerebral infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a cerebral infarction. On univariate analysis, occurrence of cerebral infarction was associated with a worse World Federation of Neurological Surgeons grade (P =0.01), use of ventriculostomy catheter (P =0.01), preoperative vasospasm (P =0.03), surgical clipping (P =0.02), symptomatic vasospasm (P <0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P <0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P <0.01) and evidence of vasospasm on TCD or angiogram predicted cerebral infarction (P <0.01). TCD and angiogram agreed on the diagnosis of vasospasm in 73% of cases (95% CI, 63% to 81%), but the diagnostic accuracy of this combination of tests was suboptimal for the prediction of cerebral infarction occurrence (sensitivity, 0.72; specificity, 0.68; positive predictive value, 0.67; negative predictive value, 0.72). Location of the cerebral infarction on delayed CT was predicted by neurological symptoms in 74%, by aneurysm location in 77%, and by angiographic vasospasm in 67%. Conclusions— Evidence of vasospasm on TCD and angiogram is predictive of cerebral infarction on CT scan but sensitivity and specificity are suboptimal. Cerebral infarction location cannot be predicted in one quarter to one third of patients by any of the studied clinical or radiological variables.
Arabidopsis DCP2, DCP1, and VARICOSE Form a Decapping Complex Required for Postembryonic Development[W]

mRNA turnover in eukaryotes involves the removal of m7GDP from the 5′ end. This decapping reaction is mediated by a protein complex well characterized in yeast and human but not in plants. The function of the decapping complex in the development of multicellular organisms is also poorly understood. Here, we show that Arabidopsis thaliana DCP2 can generate from capped mRNAs, m7GDP, and 5′-phosphorylated mRNAs in vitro and that this decapping activity requires an active Nudix domain. DCP2 interacts in vitro and in vivo with DCP1 and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1. Moreover, the interacting proteins stimulate DCP2 activity, suggesting that the three proteins operate as a decapping complex. Consistent with their role in mRNA decay, DCP1, DCP2, and VCS colocalize in cytoplasmic foci, which are putative Arabidopsis processing bodies. Compared with the wild type, null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. We conclude that mRNA turnover mediated by the decapping complex is required for postembryonic development in Arabidopsis.
Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines.

CONTEXT Many groups have developed guidelines to shorten hospital length of stay in pneumonia in order to decrease costs, but the length of time until a patient hospitalized with pneumonia becomes clinically stable has not been established. OBJECTIVE To describe the time to resolution of abnormalities in vital signs, ability to eat, and mental status in patients with community-acquired pneumonia and assess clinical outcomes after achieving stability. DESIGN Prospective, multicenter, observational cohort study. SETTING Three university and 1 community teaching hospital in Boston, Mass, Pittsburgh, Pa, and Halifax, Nova Scotia. PATIENTS Six hundred eighty-six adults hospitalized with community-acquired pneumonia. MAIN OUTCOME MEASURES Time to resolution of vital signs, ability to eat, mental status, hospital length of stay, and admission to an intensive care, coronary care, or telemetry unit. RESULTS The median time to stability was 2 days for heart rate (< or =100 beats/min) and systolic blood pressure (> or =90 mm Hg), and 3 days for respiratory rate (< or =24 breaths/min), oxygen saturation (> or =90%), and temperature (< or =37.2 degrees C [99 degrees F]). The median time to overall clinical stability was 3 days for the most lenient definition of stability and 7 days for the most conservative definition. Patients with more severe cases of pneumonia at presentation took longer to reach stability. Once stability was achieved, clinical deterioration requiring intensive care, coronary care, or telemetry monitoring occurred in 1% of cases or fewer. Between 65% to 86% of patients stayed in the hospital more than 1 day after reaching stability, and fewer than 29% to 46% were converted to oral antibiotics within 1 day of stability, depending on the definition of stability. CONCLUSIONS Our estimates of time to stability in pneumonia and explicit criteria for defining stability can provide an evidence-based estimate of optimal length of stay, and outline a clinically sensible approach to improving the efficiency of inpatient management.
Islet Transplantation in Type 1 Diabetes Mellitus Using Cultured Islets and Steroid‐Free Immunosuppression: Miami Experience

Following the success obtained with transplantation of fresh human islets under steroid‐free immunosuppression, this trial evaluated the transplantation of islets that had undergone a period of in vitro culture and the potential of tumor necrosis factor (TNF‐α) blockade to improve islet engraftment. Subjects included 16 patients with type 1 diabetes mellitus (T1DM); half were randomly assigned to receive Infliximab immediately preceding initial infusion. Immunosuppression consisted of daclizumab induction and sirolimus/tacrolimus maintenance. Out of 16 subjects 14 achieved insulin independence with one or two islet infusions; adverse events precluded completion in two. Without supplemental infusions, 11/14 (79%) subjects were insulin independent at 1 year, 6/14 (43%) at 18 months; these same subjects remain insulin independent at 33 ± 6 months. While on immunosuppression, all patients maintained graft function. Out of 14 patients, 8 suffered chronic partial graft loss, likely immunological in nature, 5 of these received supplemental infusions. Currently, 11 subjects remain on immunosuppression, 8 (73%) are insulin independent, two with supplemental infusions. Insulin independent subjects demonstrated normalization of HbA1c, fructosamine and Mean Amplitude of Glycemic Excursions (MAGE) values. No clinical benefit of infliximab was identified. These results demonstrate that transplantation of cultured human islet allografts results in reproducible insulin independence in all subjects under this immunosuppressive regimen, comparable to that of freshly transplanted islets (Edmonton protocol).
Computers in Human Behavior

We introduce a new approach to monitoring the activity of smartphone users based on their physical interactions with the interface. Typical events are taps, scrolling and typing, carried out to interact with apps. As compared to other measures, this directly encapsulates potential problematic physical smartphone behaviour as a signal. The approach contrasts against conventions such as self-reporting or timing activity sessions, and it focusses on active rather than passive smartphone activity. Using this alternative method, we collected all user interface interaction events from a sample of 64 participants over a period of 8 weeks, using a bespoke monitoring app called Tymer. User Smartphone Addiction was seen to signi ﬁ cantly correlate with high levels of interaction with Lifestyle apps, particularly for female users. Interactions with Social apps in general were also associated with Smartphone Addiction. In particular, user interactions with Snapchat correlated with Smartphone Addiction, represented across all types of interface interaction. This is signi ﬁ cant given the widespread usage of Snapchat by teenagers, and we hypothesise that the app's design provides a particularly strong pathway in support of Smartphone Addiction.
Eventera: Real-Time Event Recommendation System from Massive Heterogeneous Online Media

Given massive heterogeneous online media, how can we summarize events, and discover causal relationships among them, in real time? Indeed we are living in a deluge of information, everyday hundreds of thousands of news articles are published, millions of postings from social media and internet forums are written, and billions of search queries are generated by Internet users. To convey user-interested news events and their big pictures for better understanding, building real-time event recommendation system is indispensable. Our proposed system, Eventera, aggregates massive online media from heterogeneous channels, summarizes them into events, discovers meaningful associations by bridging the events, and generates a sequence map of events that provides a big picture of how real life events interact with each other over time. We demonstrate how our system help users understand events and their causal relationships effectively.
Influence of Silicon Texturization on the Photovoltaic Properties of CuPc/n-Si Hybrid Solar Cells

Hybrid solar cell based on copper-phthalocyanine (CuPc) and textured Si has been fabricated. Influence of silicon texturization on the photovoltaic properties of CuPc/n-Si hybrid solar cell was studied by current-voltage characteristic curves in the dark and under illumination conditions. As a result, it is found that textured Si can improve significantly the performance of hybrid solar cell. It exhibits a three times increase in the short-circuit current density with respect to that of the standard hybrid solar cell, and the short-circuit current density reaches up to 5.4 mA/cm2. In addition, the open-voltage and fill factor are almost constant. The solar-energy conversion efficiency is increased by about three times by the textured Si and achieved about 0.8% under “one Sun” illumination. Furthermore, the possible reasons for this result have been discussed.
Hypothalamic Arcuate Nucleus Mediates the Sympathetic and Arterial Pressure Responses to Leptin

Leptin is an adipocyte-derived hormone that plays an important role in the regulation of energy homeostasis through its action in the central nervous system. Leptin decreases body weight by promoting satiety and increasing thermogenesis via increasing sympathetic nerve activity (SNA) to brown adipose tissue. Leptin also increases renal SNA and arterial pressure. The arcuate nucleus is considered as a major nucleus for leptin action on energy homeostasis. We tested whether leptin action in the arcuate nucleus simultaneously activates SNA to brown adipose tissue and the kidney. The sympathetic and cardiovascular responses to intra-arcuate injection of leptin were compared with those evoked by intracerebroventricular administration of leptin in rat. Intracerebroventricular administration of leptin (10 &mgr;g) caused a significant increase in SNA to brown adipose tissue and the kidney. Intracerebroventricular leptin also increased mean arterial pressure. Direct injection of leptin (500 ng) into the arcuate nucleus increased both brown adipose tissue (254±49%; P<0.001 versus vehicle) and renal SNA (111±31%; P<0.001 versus vehicle). Microinjection of leptin into the arcuate nucleus also produced a substantial increase in mean arterial pressure (from 82±3 to 100±7 mm Hg; P=0.02). These data demonstrate that leptin action in the arcuate nucleus of the hypothalamus is important for the control of sympathetic outflow to both brown adipose tissue and the kidney. These results also suggest that the cardiovascular effects of leptin might be evoked by the action of this hormone in the arcuate nucleus of the hypothalamus.
Malware detection and classification based on extraction of API sequences

With the substantial growth of IT sector in the 21st century, the need for system security has also become inevitable. While the developments in the IT sector have innumerable advantages but attacks on websites and computer systems are also increasing relatively. One such attack is zero day malware attack which poses a great challenge for the security testers. The malware pen testers can use bypass techniques like Compression, Code obfuscation and Encryption techniques to easily deceive present day Antivirus Scanners. This paper elucidates a novel malware identification approach based on extracting unique aspects of API sequences. The proposed feature selection method based on N grams and odds ratio selection, capture unique and distinct API sequences from the extracted API calls thereby increasing classification accuracy. Next a model is built by the classification algorithms using active machine learning techniques to categorize malicious and benign files.
The Adverse Effects of Drugs on the Blood

For many years haematologists have been well aware of drug induced diseases as a cause of morbidity and not uncommonly of death. Agranulocytosis due to amidopyrine was causing fatalities as early as the 1920s, although it was not until 1935 that Plum recognized the association. He drew an exact parallel between the increased incidence of agranulocyt.osis occurring in Denmark and the augmented sale of amidopyrine. The way in which the drug caused leucopenia was not clear. The common blood disorders following drug therapy are haemolytic anaemia, aplastic or hypoplastic anaemia, thrombocytopenia, agranulocytosis and megaloblastic anaemia. To a lesser extent there may be found rnethaemoglobinaemia, sulphhaemoglobinaemia and leukaemia or one of the lymphomas. Several hundred drugs have been implicated at some time or other in the pathogenesis of such disorders though frequently direct proof has not been forthcoming, nor has the mechanism of action been adequately displayed. There are, however, some outstanding exceptions to this rule where the complete mechanism of drug interaction with blood cell has been exposed. Interactions fall broadly into two categories, in that they may be immunological or 110nimmunological (Wintrobe, 1969; Girdwood, 1971; Worlledge, 1973; l\IcVie, 1973). Examples are given in Tables I and II. In either case the site of interaction may be in the marrow on the precursors of blood cells or directly on the cells as they circulate. Sometimes the mechanism appears to act both centrally and peripherally at the same time.
Effects of Scheduled Exercise on Cancer-Related Fatigue in Women with Early Breast Cancer

While physical activity during cancer treatment is found beneficial for breast cancer patients, evidence indicates ambiguous findings concerning effects of scheduled exercise programs on treatment-related symptoms. This study investigated effects of a scheduled home-based exercise intervention in breast cancer patients during adjuvant chemotherapy, on cancer-related fatigue, physical fitness, and activity level. Sixty-seven women were randomized to an exercise intervention group (n = 33, performed strength training 3x/week and 30 minutes brisk walking/day) and a control group (n = 34, performed their regular physical activity level). Data collection was performed at baseline, at completion of chemotherapy (Post1), and 6-month postchemotherapy (Post2). Exercise levels were slightly higher in the scheduled exercise group than in the control group. In both groups, cancer-related fatigue increased at Post1 but returned to baseline at Post2. Physical fitness and activity levels decreased at Post1 but were significantly improved at Post2. Significant differences between intervention and control groups were not found. The findings suggest that generally recommended physical activity levels are enough to relief cancer-related fatigue and restore physical capacity in breast cancer patients during adjuvant chemotherapy, although one cannot rule out that results reflect diminishing treatment side effects over time.
Asia's family planning programs as low fertility is attained.

The dramatic demographic changes in Asia during the three decades from 1970 to the end of the twentieth century were matched by major changes in government population policies and programs. Fertility declines occurred in widely different economic, sociocultural, and political settings. The extent to which they were attributable to family planning programs, established in most countries of the region by 1970, is hotly debated. The 1970s were the heyday of family planning programs, which were created in a climate of urgency because of concerns over the "population explosion. " Issues faced by programs at that time are discussed. Over time, programs generally have moved to a simpler "service" approach. As increasing numbers of countries reach replacement-level fertility, and as policies are formed against the background of the 1994 International Conference on Population and Development held in Cairo, the role of family planning programs is increasingly debated and questioned. This article examines the responses of Asian countries and the population challenges that remain.
Galaxy-cluster gas-density distributions of the Representative XMM-Newton Cluster Structure Survey (REXCESS)

We present a study of the structural and scaling properties of the gas distributions in the intracluster medium (ICM) of 31 nearby (z 3 keV scale self-similarly, with no temperature dependence of gas-density normalisation. The REXCESS sample allows us to investigate the correlations between cluster properties and dynamical state. We find no evidence of correlations between cluster dynamical state and either the gas density slope in the inner regions or temperature, but do find some evidence of a correlation between dynamical state and outer gas density slope. We also find a weak correlation between dynamical state and both central gas normalisation and inner cooling times, but this is only significant at the 10% level. We conclude that, for the X-ray cluster population as a whole, both the central gas properties and the angle-averaged, large-scale gas properties are linked to the cluster dynamical state. We also investigate the central cooling times of the clusters. While the cooling times span a wide range, we find no evidence of a significant bimodality in the distributions of central density, density gradient, or cooling time. Finally, we present the gas mass-temperature relation for the REXCESS sample, finding that h(z)Mgas ∝ T 1.99±0.11 , which is consistent with the expectation of self-similar scaling modified by the presence of an entropy excess in the inner regions of the cluster and consistent with earlier work on relaxed cluster samples. We measure a logarithmic intrinsic scatter in this relation of ∼10%, which should be a good measure of the intrinsic scatter in the Mgas−T relation for the cluster population as a whole.