Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae

Polyamines are essential biogenic poly-cations with important roles in many cellular processes and diseases such as cancer. A rate-limiting step early in the biosynthesis of polyamines is the conversion of ornithine to putrescine by the homodimeric enzyme ornithine decarboxylase (ODC). In a conserved mechanism of posttranslational regulation, ODC antizyme (OAZ) binds to ODC monomers promoting their ubiquitin-independent degradation by the proteasome. Decoding of OAZ mRNA is unusual in that it involves polyamine-regulated bypassing of an internal translation termination (STOP) codon by a ribosomal frameshift (RFS) event. Using Saccharomyces cerevisiae, we earlier showed that high polyamine concentrations lead to increased efficiency of OAZ1 mRNA translation by binding to nascent Oaz1 polypeptide. The binding of polyamines prevents stalling of the ribosomes on OAZ1 mRNA caused by nascent Oaz1 polypeptide thereby promoting synthesis of full-length Oaz1. Polyamine depletion, however, also inhibits RFS during the decoding of constructs bearing the OAZ1 shift site lacking sequences encoding the Oaz1 parts implicated in polyamine binding. Polyamine depletion is known to impair hypusine modification of translation factor eIF5A. Using a novel set of conditional mutants impaired in the function of eIF5A/Hyp2 or its hypusination, we show here that hypusinated eIF5A is required for efficient translation across the OAZ1 RFS site. These findings identify eIF5A as a part of Oaz1 regulation, and thereby of polyamine synthesis. Additional experiments with DFMO, however, show that depletion of polyamines inhibits translation across the OAZ1 RFS site not only by reducing Hyp2 hypusination, but in addition, and even earlier, by affecting RFS more directly.
Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review

Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal host–microbe homeostasis, manifested by the destruction of tooth-supporting structures, especially inflammatory alveolar bone loss. Osteoporosis is characterized by systemic deterioration of bone mass and microarchitecture. The roles of many systemic factors have been identified in the pathogenesis of osteoporosis, including endocrine change, metabolic disorders, health-impaired behaviors and mental stress. The prevalence rate of osteoporotic fracture is in sustained elevation in the past decades. Recent studies suggest that individuals with concomitant osteoporosis are more vulnerable to periodontal impairment. Current reviews of worse periodontal status in the context of osteoporosis are limited, mainly centering on the impacts of menopausal and diabetic osteoporosis on periodontitis. Herein, this review article makes an effort to provide a comprehensive view of the relationship between osteoporosis and periodontitis, with a focus on clarifying how those risk factors in osteoporotic populations modify the alveolar bone homeostasis in the periodontitis niche.
Content That Engages Your Customers: The Role of Brand Congruity and Promotions in Social Media

Every day, social network users worldwide spend an average of 1 hour and 47 minutes on platforms such as Facebook, Instagram, Twitter, and YouTube, and they forward online content to friends. Nonetheless, 87% of posts to brand Facebook pages go unanswered. To reduce this negative outcome and attract fans’ attention, companies post content that is not necessarily congruent with their brand and that contains promotion-based themes. The question is whether this strategy is effective in boosting rebroadcasting. The authors propose a conceptual framework that explains how two key post themes—congruency and promotions—influence consumers’ propensity to share and why. They validate it through a multimethod approach. First, the authors document the existence of the effect between congruency, promotions, and rebroadcasting by analyzing one year of posts for four leading brands. Second, the authors run a field experiment with Samsung Mobile. They find that the degree of congruency between online content and the brand positively affects the amount of rebroadcasting. Posts that include promotional incentives generate fewer shares, but this negative effect reverses when the post is congruent with the brand. Third, the authors conduct two online lab experiments to explain why this happens and show that fans’ reactance and altruistic motives play a central role.
Revealing the dust grain size in the inner envelope of the Class I protostar Per-emb-50

Context. A good constraint of when the growth of dust grains from sub-micrometer to millimeter sizes occurs, is crucial for planet formation models. This provides the first step towards the production of pebbles and planetesimals in protoplanetary disks. Currently, it is well established that Class II objects have large dust grains. However, it is not clear when in the star formation process this grain growth occurs. Aims. We use multi-wavelength millimeter observations of a Class I protostar to obtain the spectral index of the observed flux densities αmm of the unresolved disk and the surrounding envelope. Our goal is to compare our observational results with visibility modeling at both, 1.3 and 2.7 mm simultaneously. Methods. We present data from NOEMA at 2.7 mm and SMA at 1.3 mm of the Class I protostar, Per-emb-50. We model the dust emission with a variety of parametric and radiative-transfer models to deduce the grain size from the observed emission spectral index. Results. We find a spectral index in the envelope of Per-emb-50 of αenv = 3.3 ± 0.3, similar to the typical ISM values. The radiative-transfer modeling of the source confirms this value of αenv with the presence of dust with a amax ≤ 100 μm. Additionally, we explore the backwarming effect, where we find that the envelope structure affects the millimeter emission of the disk. Conclusions. Our results reveal grains with a maximum size no larger than 100 μm in the inner envelope of the Class I protostar Per-emb-50, providing an interesting case to test the universality of millimeter grain growth expected in these sources.
Freezing and large time scales induced by geometrical frustration

We investigate the properties of an effective Hamiltonian with competing interactions involving spin and chirality variables, relevant for the description of the trimerized version of the spin-½ kagome antiferromagnet. Using classical Monte Carlo simulations, we show that remarkable behaviors develop at very low temperatures. Through an entropic selection mechanism, the low-energy states are characterized by a dynamical freezing of the chiralities, which decouples the lattice into "dimers" and "triangles" of antiferromagnetically coupled spins. Under the presence of an external magnetic field, the particular topology of the chiralities induces a very slow spin dynamics, reminiscent of what happens in ordinary spin glasses.
Impact of Evening Light Exposures with Different Solid Angles on Circadian Melatonin Rhythms, Alertness, and Visual Comfort in an Automotive Setting

Future automotive interior lighting might have the potential to go beyond decorative purposes by influencing alertness, circadian physiology, and sleep. As the available space in the interior of an automobile for lighting applications is limited, understanding the impact of various luminous surface sizes on non-image-forming effects is fundamental in this field. In a laboratory study using a within-subject design, 18 participants were exposed to two bright light conditions with different solid angles and one dim light condition in a balanced, randomized order during the course of the evening. Our results demonstrate that both light conditions significantly increased subjective alertness and reduced salivary melatonin concentration but not cognitive performance compared to dim light. The solid angle of light exposure at constant corneal illuminance only affected visual comfort. While subjective alertness can be increased and melatonin can be attenuated with rather small luminaires, larger solid angles should be considered if visual comfort is a priority.
Model GW band structure of InAs and GaAs in the wurtzite phase

We report quasiparticle calculations of the newly observed wurtzite polymorph of InAs and GaAs. The calculations are performed in the GW approximation (based on a model dielectric function) using plane waves and pseudopotentials. For comparison we also report the study of the zinc-blende phase within the same approximations. In the InAs compound the In 4d electrons play a very important role: whether they are frozen in the core or not leads either to a correct or a wrong band ordering (negative gap) within the local-density appproximation (LDA). We have calculated the GW band structure in both cases. In the first approach, we have estimated the correction to the pd repulsion calculated within the LDA and included this effect in the calculation of the GW corrections to the LDA spectrum. In the second case, we circumvent the negative gap problem by first using the screened exchange approximation and then calculating the GW corrections starting from the so obtained eigenvalues and eigenfunctions. This approach, that can be thought of as a step towards self-consistency, leads to a more realistic band structure and was also used for GaAs. For both InAs and GaAs in the wurtzite phase we predict an increase of the quasiparticle gap with respect to the zinc-blende polytype.
A comparison of numerical flux formulas for the Euler and Navier-Stokes equations

Numerical flux formulas for the convection terms in the Euler or Navier-Stokes equations are analyzed with regard to their accuracy in representing steady nonlinear and linear waves (shocks and entropy/shear waves, respectively). Numerical results are obtained for a one-dimensional conical Navier-Stokes flow including both a shock and a boundary layer. Analysis and experiments indicate that for an accurate representation of both layers the flux formula must include information about all different waves by which neighboring cells interact, as in Roe's flux-difference splitting. In comparison, Van Leer's flux-vector splitting, which ignores the linear waves, badly diffuses the boundary layer. The results of MacCormack's scheme, if properly tuned, are significantly better. The use of a sufficiently detailed flux formula appears to reduce the number of cells required to resolve a boundary layer by a factor 1/2 to 1/4 and thus pays off.
Microfinance Services and Government Regulations: Reflections on Performance of Small Holder Coffee Entrepreneurs in Uganda

Small-scale enterprises are lauded around the world for their contribution to economic development. Resources and capabilities play an important role as accelerators of entrepreneurial activity and also increase enterprise performance. This research strived to understand how Microfinance services affect the performance of smallholder coffee entrepreneurs but also examine government regulations as a moderating variable for the association between microfinance and the performance of smallholder coffee entrepreneurs. The study was guided by the resource-based view supported by dynamic capability and contingency theories. Data on 400 Ugandan coffee entrepreneurs was gathered and statistically tested using a multiple linear regression model. Study scores noted that financial training, microcredit, saving mobilization, and farm inputs positively influence the performance of smallholder coffee entrepreneurs. The findings also established that government regulations negatively moderate the association between microfinance services and the performance of smallholder coffee entrepreneurs. The study contributes to the growing agricultural entrepreneurship literature by demonstrating the performance of coffee entrepreneurs amidst microfinance and strict government regulations.
Eikonal Tomography With Physics‐Informed Neural Networks: Rayleigh Wave Phase Velocity in the Northeastern Margin of the Tibetan Plateau

We present a novel eikonal tomography approach using physics‐informed neural networks (PINNs) for Rayleigh wave phase velocities based on the eikonal equation. The PINN eikonal tomography (pinnET) neural network utilizes deep neural networks as universal function approximators and extracts traveltimes and velocities of the medium during the optimization process. Whereas classical eikonal tomography uses a generic non‐physics based interpolation and regularization step to reconstruct traveltime surfaces, optimizing the network parameters in pinnET means solving a physics constrained traveltime surface reconstruction inversion tackling measurement noise and satisfying physics. We demonstrate this approach by applying it to 25 s surface wave data from ChinArray II sampling the northeastern Tibetan plateau. We validate our results by comparing them to results from conventional eikonal tomography in the same area and find good agreement.
Postconditioning by Delayed Administration of Ciclosporin A: Implication for Donation after Circulatory Death (DCD)

Heart transplantation is facing a shortage of grafts. Donation after Circulatory Death (DCD) would constitute a new potential of available organs. In the present work, we aimed to evaluate whether Postconditioning (ischemic or with ciclosporin-A (CsA)) could reduce ischemia-reperfusion injury in a cardiac arrest model when applied at the start of reperfusion or after a delay. An isolated rat heart model was used as a model of DCD. Hearts were submitted to a cardiac arrest of 40 min of global warm ischemia (37 °C) followed by 3 h of 4 °C-cold preservation, then 60 min reperfusion. Hearts were randomly allocated into the following groups: control, ischemic postconditioning (POST, consisting of two episodes each of 30 s ischemia and 30 s reperfusion at the onset of reperfusion), and CsA group (CsA was perfused at 250 nM for 10 min at reperfusion). In respective subgroups, POST and CsA were applied after a delay of 3, 10, and 20 min. Necrosis was lower in CsA and POST versus controls (p < 0.01) whereas heart functions were improved (p < 0.01). However, while the POST lost its efficacy if delayed beyond 3 min of reperfusion, CsA treatment surprisingly showed a reduction of necrosis even if applied after a delay of 3 and 10 min of reperfusion (p < 0.01). This cardioprotection by delayed CsA application correlated with better functional recovery and higher mitochondrial respiratory index. Furthermore, calcium overload necessary to induce mitochondrial permeability transition pore (MPTP) opening was similar in all cardioprotection groups, suggesting a crucial role of MPTP in this delayed protection of DCD hearts.
DIRECT Distances to Nearby Galaxies Using Detached Eclipsing Binaries and Cepheids. VIII. Additional Variables in the Field M33B Discovered with Image Subtraction

DIRECT is a project to obtain directly the distances to two Local Group galaxies, M31 and M33, which occupy a crucial position near the bottom of the cosmological distance ladder. As the first step of the DIRECT project we have searched for detached eclipsing binaries (DEBs) and new Cepheids in the M31 and M33 galaxies with 1 m class telescopes. In this eighth paper we present a catalog of variable stars discovered in the data from the follow-up observations of DEB system D33J013337.0+303032.8 in field M33B [(α, δ) = (23.°48, 30.°57), J2000.0], collected with the Kitt Peak National Observatory 2.1 m telescope. In our search covering an area of 108 arcmin2 we have found 895 variable stars: 96 eclipsing binaries, 349 Cepheids, and 450 other periodic, possibly long-period or nonperiodic variables. Of these variables 612 are newly discovered. Their light curves were extracted using the ISIS image subtraction package. For 77% of the variables we present light curves in standard V and B magnitudes, with the remaining 23% expressed in units of differential flux. We have discovered a population of first-overtone Cepheid candidates, and for six of them we present strong arguments in favor of this interpretation. The catalog of variables, as well as their photometry (about 9.2 × 104 BV measurements) and finding charts, is available electronically via anonymous ftp and the World Wide Web. The complete set of the CCD frames is available upon request.
Simulating Polymerization by Boltzmann Inversion Force Field Approach and Dynamical Nonequilibrium Reactive Molecular Dynamics

The radical polymerization process of acrylate compounds is, nowadays, numerically investigated using classical force fields and reactive molecular dynamics, with the aim to probe the gel-point transition as a function of the initial radical concentration. In the present paper, the gel-point transition of the 1,6-hexanediol dimethacrylate (HDDMA) is investigated by a coarser force field which grants a reduction in the computational costs, thereby allowing the simulation of larger system sizes and smaller radical concentrations. Hence, the polymerization is investigated using reactive classical molecular dynamics combined with a dynamical approach of the nonequilibrium molecular dynamics (D-NEMD). The network structures in the polymerization process are probed by cluster analysis tools, and the results are critically compared with the similar all-atom system, showing a good agreement.
VSS controller design for discrete-time systems

This paper presents an optimal and robust VSS controller for discrete-time systems. Firstly, a VSS control law is designed, which enables the system state to move into a sliding sector where the closed-loop system is stable. Then optimal control theory is used to design an optimal sliding sector. Finally, the bounded parameter uncertainty is taken into consideration, the robustness of the VSS control system is shown. The simulation of the pendulum control system shows that the VSS controller proposed in this paper is stable and robust to bounded parameter uncertainty. <<ETX>>
Assessing the Influence of Child Sexual Behavior on Depression among Black SMM in the Southeastern United States

Limited studies have examined the associations between child sexual abuse (CSA) and depression among Black sexual minority men (SMM) in the Southeastern United States (US). As, such, the current study examined the critical gap in understanding the impact of CSA on Black SMM’s mental health. Specifically, we tested the associations between contextual CSA factors and depression among a large population-based sample of Black SMM living in two cities in the Southern US. Data were obtained from the MARI Study, a sample of Black SMM ages 18–66 years, recruited from the Jackson, MS and Atlanta, GA metropolitan areas (n = 507). Depression was assessed using the 9-item CES-D scale. We conducted multivariable regression analyses to examine the association between depression with history of CSA and other child sexual-related variables (i.e., age of perpetrator and age of sexual abuse), controlling for key confounders. Our results indicated that CSA (β = 0.14, p < 0.001) was positively associated with depression. Our results also indicated that Black SMM who reported being sexually abused at the ages of 6 to 10 (β = 0.30, p < 0.01) and 16 to 18 (β = 0.25, p < 0.05) were positively associated with depression. These findings suggest that there is a need to provide culturally and safe mental health services in the Southeastern US for CSA survivors.
On Integral Upper Limits Assuming Power-law Spectra and the Sensitivity in High-energy Astronomy

The high-energy non-thermal universe is dominated by power-law-like spectra. Therefore, results in high-energy astronomy are often reported as parameters of power-law fits, or, in the case of a non-detection, as an upper limit assuming the underlying unseen spectrum behaves as a power law. In this paper, I demonstrate a simple and powerful one-to-one relation of the integral upper limit in the two-dimensional power-law parameter space into the spectrum parameter space and use this method to unravel the so-far convoluted question of the sensitivity of astroparticle telescopes.
Real-Time Investigation of Temperature Effect on Induction Motor Equivalent Circuit Parameter Change

Today’s developing technology and increasing demands in production areas continue the importance of studies on induction motors (IMs). To meet the demands, the mathematical modeling of IMs must be performed fully and accurately. Variable conditions cause changes in many electrical, magnetic, and thermal parameters. A change in parameters affects the intensity, efficiency of the operating currents of the machine, thereby changing the motor losses. In this article, the objective is to determine the changes in the equivalent circuit parameters of three-phase squirrel-cage induction motors (SCIMs) with different powers under the variable conditions (stator winding temperature, load, and motor shaft speed). Supervisory control and data acquisition (SCADA) program read real-time information (temperature, current, voltage, power, shaft speed, and torque) from the experiments and necessary calculations were made. When the test results were examined, a maximum of 9 % change was observed in the motor ECPs (RS, R2, RM, XS, X2, and XM) at different shaft speeds as a result of the change in the stator winding temperature between 100 % and 110 %. At different loads, this rate of change increases to 16 %. This has shown that motor shaft speed and load, together with temperature, have a significant effect on the ECPs.
Remote, Whole-Body Interval Training Improves Muscular Endurance and Cardiac Autonomic Control in Young Adults

High-intensity interval training (HIIT) is an exercise modality acknowledged to maintain physical fitness with more engagement in an active lifestyle compared with other traditional exercise models. Nevertheless, its effects on cardiac control and physical performance in an online-guided setting are not yet clarified. The present work assessed physical fitness and heart rate variability (HRV) before and after an online, home-based HIIT program in college-age students while pandemic lockdowns were in effect. Twenty university students (age: 21.9 ± 2.4 years.) that were solely enrolled in online classes were distributed into three groups: control—CON-(n = 6), 14 min of HIIT—HIIT-14-(n = 8), and 21 min of HIIT—HIIT-21-(n = 6). A maximal push-up test was employed to assess muscular endurance and performance, and resting HRV signals were collected with wireless heart rate monitors and were processed in Kubios HRV Std. (Kubios Oy, Finland). There was an increase in total push-up capacity compared to CON (p < 0.05 HIIT-21 vs. CON; p < 0.001 HIIT-14 vs. CON) after 8 weeks. A significant interaction was observed in high-frequency and low-frequency spectra ratios after the HIIT-21 intervention (p < 0.05). The current work demonstrated that either short- or mid-volume online, whole-body HIIT improves muscle strength, whereas mid-volume HIIT (HIIT-21) was the only intervention that developed a sympathovagal adaptation. This study showed promising results on muscular endurance and cardiac autonomic modulation through whole-body HIIT practice at home.