Miracle-dz/UniFAR-FTUs huggingface dataset:
Counter play-out: Executing unrealizable scenario-based specifications

The scenario-based approach to the specification and simulation of reactive systems has attracted much research efforts in recent years. While the problem of synthesizing a controller or a transition system from a scenario-based specification has been studied extensively, no work has yet effectively addressed the case where the specification is unrealizable and a controller cannot be synthesized. This has limited the effectiveness of using scenario-based specifications in requirements analysis and simulation. In this paper we present counter play-out, an interactive debugging method for unrealizable scenario-based specifications. When we identify an unrealizable specification, we generate a controller that plays the role of the environment and lets the engineer play the role of the system. During execution, the former chooses environment's moves such that the latter is forced to eventually fail in satisfying the system's requirements. This results in an interactive, guided execution, leading to the root causes of unrealizability. The generated controller constitutes a proof that the specification is conflicting and cannot be realized. Counter play-out is based on a counter strategy, which we compute by solving a Rabin game using a symbolic, BDD-based algorithm. The work is implemented and integrated with PlayGo, an IDE for scenario-based programming developed at the Weizmann Institute of Science. Case studies show the contribution of our work to the state-of-the-art in the scenario-based approach to specification and simulation.
Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV

The large human efficacy trail in Thailand, RV144, was concluded in the summer of 2009. This is the first Phase III trial to show limited, but significant, efficacy in preventing HIV acquisition. This trial represents the first sign that a preventive vaccine for HIV may be feasible. The vaccine regimen tested in Thailand consisted of priming with a Canarypox vector carrying three synthetic HIV genes. The priming was followed by booster inoculations with two recombinant envelope proteins from HIV, clade B and E. The need to understand the role in protection from HIV acquisition of the new responses, induced by this vaccine combination, has brought together many researchers with the common goal of improving the development of a safe and effective vaccine for HIV.
The efficacy of virtual reality simulation training in laparoscopy: a systematic review of randomized trials

Background. Virtual reality (VR) simulators for surgical training might possess the properties needed for basic training in laparoscopy. Evidence for training efficacy of VR has been investigated by research of varying quality over the past decade. Objective. To review randomized controlled trials regarding VR training efficacy compared with traditional or no training, with outcome measured as surgical performance in humans or animals. Data sources. In June 2011 Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science and Google Scholar were searched using the following medical subject headings (MeSh) terms: Laparoscopy/standards, Computing methodologies, Programmed instruction, Surgical procedures, Operative, and the following free text terms: Virtual real* OR simulat* AND Laparoscop* OR train* Limits: Controlled trials. Study eligibility criteria. All randomized controlled trials investigating the effect of VR training in laparoscopy, with outcome measured as surgical performance. Methods. A total of 98 studies were screened, 26 selected and 12 included, with a total of 241 participants. Results. Operation time was reduced by 17–50% by VR training, depending on simulator type and training principles. Proficiency‐based training appeared superior to training based on fixed time or fixed numbers of repetition. Simulators offering training for complete operative procedures came out as more efficient than simulators offering only basic skills training. Conclusions. Skills in laparoscopic surgery can be increased by proficiency‐based procedural VR simulator training. There is substantial evidence (grade IA – IIB) to support the use of VR simulators in laparoscopic training.
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique system for human therapeutic antibody discovery and a model to study heavy chain repertoire diversity in the context of a constant light chain. The purpose of this study was to analyze heavy chain variable gene usage, clonotype diversity, and to describe the sequence characteristics of antigen-specific monoclonal antibodies (mAbs) isolated from immunized OmniFlic animals. Using next-generation sequencing antibody repertoire analysis, we measured heavy chain variable gene usage and the diversity of clonotypes present in the lymph node germinal centers of 75 OmniFlic rats immunized with 9 different protein antigens. Furthermore, we expressed 2,560 unique heavy chain sequences sampled from a diverse set of clonotypes as fixed light chain antibody proteins and measured their binding to antigen by ELISA. Finally, we measured patterns and overall levels of somatic hypermutation in the full B-cell repertoire and in the 2,560 mAbs tested for binding. The results demonstrate that OmniFlic animals produce an abundance of antigen-specific antibodies with heavy chain clonotype diversity that is similar to what has been described with unrestricted light chain use in mammals. In addition, we show that sequence-based discovery is a highly effective and efficient way to identify a large number of diverse monoclonal antibodies to a protein target of interest.
Preparation and characterization of plasma-polymerized diphenyl thin films

A capacitively coupled plasma polymerization system was designed and fabricated for plasma polymer deposition. Transparent and light yellow colour plasma-polymerized diphenyl (PPDP) thin films were deposited by a dry and flawless process using the fabricated plasma polymerization system. The surface morphology of the PPDP film has been studied by scanning electron spectroscopy (SEM) and was observed to be uniform, pinhole and fracture-free. The studies of the PPDP using the elemental analysis (EA), xray photoelectron microscopy (XPS), Auger electron spectroscopy (AES) and infrared (IR) spectroscopic analyses indicate that the PPDP is chemically and structurally different from that of the monomer diphenyl. The empirical formula of the PPDP film is C9.oJH4. 0l01.06N0. 46. The chemical characteristics of the PPDP thin films were studied by AES and XPS techniques and similar result was found. It is found that the surface and bulk atomic concentrations of the constituent elements of the PPDP film are different. The IR analyses reveal that cyclizationlaggregation by conjugation occurs in the PPDP structure on heat treatment which is partially relieved on aging. The differential scanning calorimetric (DSC) investigations identify the different phase transitions in the asdeposited and heat-treated PPDP. The thermogravimetric analyses (TGA) have shown that the thermal degradation of PPDP occurs in two different steps. The optical properties have been evaluated by ultraviolet-visible (UV-Vis) spectroscopic studies of as-deposited, heat-treated and aged (as-deposited and heattreated) PPDP thin films. The bandgap energies are about 3.59 and 4.08 eV for unaged and aged PPDP films respectively. The optical band gap does not change much on heat treatment but increases on aging. Direct and indirect transitions are identified and these energy gaps are calculated for the PPDP films. The current density-voltage (J-V) characteristics of as-deposited and heat-treated PPDP films have been studied in the voltage region from 0.2 to 15.0 V. The PooleFrenkel conduction mechanism is observed to be operative in both type of PPDP samples. The thermally activated conduction process in different as-deposited and heat-treated PPDP films were examined from 298 to 523 K. The activation energies (tl.E) suggest that electrons and/or holes from traps and/or sublevels are active in the low temperature region and in the high temperature region ions from the material are involved in the conduction process.
Low-Power Effective Memory-Size Expanded TCAM Using Data-Relocation Scheme

This paper proposes a low-power effective memory-size expanded ternary content addressable memory (TCAM). The IP address of IPv6 extends to 128 bits, where the prefix bits store `0' or `1' and the remaining bits store `X' (don't care). Most prefixes are much shorter than 128 bits, so many TCAM cells store `X'. The proposed data-relocation TCAM (DR-TCAM) increases the number of IP addresses stored in the TCAM by relocating the data in the prefix bits into `X' cells. The DR-TCAM has four types of banks. The type-0 bank is empty and inactivated. The type-1 and type-2 banks store four 32 bit words and two 64 bit words instead of a 128 bit word in the type-3 bank, respectively. Therefore, the type-1 and type-2 banks store four and two times larger IP addresses, respectively. In the simulation, the area and power consumption of the DR-TCAM decreased to 34% and 36% of those of the conventional TCAM for 4 K IP addresses, respectively. The DR-TCAM chip with 256 × 128 bit TCAM cells and 8 banks was fabricated using a 1.2 V 0.13 μm CMOS process. Its area was 0.87 mm 2 . Its energy/bit/search was 1.3 fJ at 200 MHz clock frequency when 4 banks were activated to store 256 IP addresses.
"Grand Visions" for Post-Capitalist Human-Computer Interaction

The design, development and deployment of new technology is a form of intervention on the social, psychological and physical world. Whether explicitly intended or not, all digital technology is designed to support some vision of how work, leisure, education, healthcare, and so on, is organised in the future [11]. For example, most efforts to make commercial systems more usable, efficient and pleasurable, are ultimately about the vision of increased profits as part of a capitalist society. This workshop will bring together researchers, designers and practitioners to explore an alternative, post-capitalist, "grand vision" for HCI, asking what kind of futures the community sees itself as working towards. Are the futures we are building towards any different from those envisioned by Silicon Valley entrepreneurs, which are typically neoliberal, absent of strict labour laws, licensing fees, tax declarations and the necessity to deal with government bureaucracy?
Ultrasound-guided peripheral nerve interventions for common pain disorders

Abstract There are a number of common pain disorders that can be managed effectively by injections around or ablation of peripheral nerves. Ultrasound is a universally available imaging tool, is safe, cost-effective, and is excellent in imaging many peripheral nerves and guiding needles to the site of the nerves. This article aims to present an overview of indications and techniques of such procedures that can be effectively performed by a radiologist.
Motion and Noise Artifact-Resilient Atrial Fibrillation Detection Using a Smartphone

Smartphone signals corrupted by motion and noise artifacts (MNAs) are often misclassified into atrial fibrillation (AF) by our previous smartphone AF detection application. We developed an MNA-tolerant AF detection algorithm for smartphones, which first detects MNAs in the smartphone signals, removes them, and finally detects AF from the MNA-free smartphone signals. To detect MNAs, we used time and frequency-domain parameters: high-pass filtered signal amplitude, successive pulse amplitude ratio, and successive maximum dominant frequency. AFs are detected using our previous AF detection algorithm based on root mean square of successive RR difference (RMSSD) and Shannon Entropy (ShE) values. The clinical results show that the accuracy, sensitivity and specificity of the proposed AF algorithm are 0.9632, 0.9341, and 0.9899, respectively.
Hiring the best

Management I struggled to straighten my tie while sitting nervously in the reception room of a well-known company. After being ushered into an office, a staffing representative tells me " No one briefed me; why are we interviewing you? " This wasn't a scene from Dil-bert; it really happened. The staffing representative was completely unprepared for the interview. I've talked to many people about their job search experiences. Their stories led to my list of " Top 10 Hiring Blunders " in the sidebar. Is your company guilty of these or similar blunders? Why is it important? In my mind, a manager with open positions has two good reasons to avoid such mistakes. First, the most influential factor in the success or failure of a software development project is the capability level of the developers. Second, there is a general shortage of computing professionals, especially in software development. A recent Business Week article (" Calling All Nerds, " March 10, 1997) stated that 190,000 information technology positions remain unfilled in the US. The best people are always in the shortest supply and highest demand. Your future success depends on the quality of the people you hire. This is the problem managers face, and thus hiring is one of the most important thing managers do. Without the right people, all of the process maturity, customer focus, and TQM in the world will not get competitive products out the door on time. To paraphrase Machiavelli, gold can't always get you good developers, but good developers can always get you gold. This column is too short to fully discuss the best hiring practices. Instead, I focus on several key principles. Understanding the several components to the hiring process is the first step toward avoiding pitfalls. The most important principle is to hire the best possible candidate with the skills to do the job. OK; this is obvious. Just because it's obvious doesn't mean your com-pany's hiring process is designed to provide it. What do I mean? To fill a position, the first thing to do is define the skills it requires. All too often, this is where hiring the best falls apart. Managers are busy and often don't take time to carefully analyze the required job skills. Instead, they copy a previous job description (perhaps changing a line or two) or they use a generic description from human resources. This can be a …
IIIDYT at SemEval-2018 Task 3: Irony detection in English tweets

In this paper we introduce our system for the task of Irony detection in English tweets, a part of SemEval 2018. We propose representation learning approach that relies on a multi-layered bidirectional LSTM, without using external features that provide additional semantic information. Although our model is able to outperform the baseline in the validation set, our results show limited generalization power over the test set. Given the limited size of the dataset, we think the usage of more pre-training schemes would greatly improve the obtained results.
Quantitative sensory testing in patients with or without ongoing pain one year after orthognathic surgery.

AIMS To (1) quantitatively investigate the possible long-term surgical impact of orthognathic surgery on the patients' trigeminal somatosensory functions and (2) investigate the influence of ongoing pain on the trigeminal somatosensory functions of the patients. METHODS A group of patients before orthognathic surgery (Pre-op), a group of patients 1 year after orthognathic surgery (Post-op), and a group of control participants (Control) were recruited (n = 28 in each group). A standardized quantitative sensory testing protocol was followed to record a battery of 13 parameters, which reflect both sensory loss and gain. The data were analyzed using three-way repeated measure analysis of variance with group and pain as between-subject factors and testing site as within-subject factor. RESULTS In the Post-op group, of the 21.4% patients who reported ongoing pain after surgery, 7.1% were diagnosed with neuropathic pain and 14.3% had musculoskeletal pain. Facial cold detection threshold (CDT) of the Post-op group was significantly lower (less sensitive) than that of the Pre-op group (P < .039). Facial pressure pain threshold (PPT) of the Post-op group was significantly lower (more sensitive) than that of the Pre-op and Control groups (P < .006). Masseter PPT of the Postop group was significantly lower than that of the Control group (P = .02). The facial vibration detection threshold (VDT) of the Post-op group was significantly higher (less sensitive) than that of the Pre-op and Control groups (P < .014). Pain patients in the Post-op group showed significantly elevated VDT compared to patients without pain (P < .001). CONCLUSION The pattern of sensory alteration in orthognathic surgical patients with or without pain was characterized by sensory loss in thermal parameters and non-nociceptive mechanosensory parameters and sensory gain in nociceptive mechanosensory parameters. The elevated VDT might be a potential indicator of the impact of postoperative pain on trigeminal somatosensory functions.
Testing attitude-behaviour theories using non-experimental data: An examination of some hidden assumptions

This chapter presents a detailed causal analysis of the two leading theories of attitude-behaviour relations, the theory of reasoned action (TRA) and the theory of planned behaviour (TPB). It is noted that the direct path from perceived behavioural control to behaviour in the TPB is causally ambiguous. Focusing on the attitude-intention relationship, timeline and path diagrams are used to illustrate some of the hidden assumptions that underlie the way these theories are usually tested using standard multiple regression applied to nonexperimental data. Randomised experiments are recommended as the best solution to the serious problems arising from omitted causes.
Interactive Interior and Proxemics Thresholds: Empowering Participants in Sensitive Conversations

The position and workings of interactive interior elements matter greatly on the relations people may enact. This paper reports on the conception and evaluation of an interactive table and its interior effects designed to support sensitive consultations between healthcare personnel, patients and relatives as they happen during treatment of cancer diseases in a hospital department of oncology. The interior design includes the physical shape of artefact, its digital functionality and how the seating around it is to take place. The design of the table is substantiated through observations of current practice, framing of the design challenge, conceptualization, and exploring form giving alternatives. Through a set of evaluations in actual use settings it is argued how the design concept of the table as interactive interior points to how notions in interaction proxemics should be rearticulated. In particular, this paper argues how proxemics thresholds should be regarded as dynamic and relational.
Medical students’ professional identity development from being actors in an objective structured teaching exercise

Abstract Introduction: Medical students develop professional identity through structured activities and impromptu interactions in various settings. We explored if contributing to an Objective Structured Teaching Exercise (OSTE) influenced students’ professional identity development. Methods: University clinical faculty members participated in a faculty development program on clinical supervision. Medical students who participated in OSTEs as simulated residents were interviewed in focus groups about what they learnt from the experience and how the experience influenced their vision of learning and teaching. Transcripts were analyzed using the Goldie’s personality and social structure perspective model. Results: Twenty-five medical students out of 32 students involved in OSTEs participated. On an institutional level, students developed a feeling of belonging to the institution. At an interactional level, students realized they could influence the teaching interaction by actively seeking or giving feedback. On the personal level, students realized that errors could become sources of learning and felt better prepared to receive faculty feedback. Conclusion: Taking part in OSTEs as a simulated resident has a positive impact on students’ vision regarding the institution as a learning environment and their own role by actively seeking or giving feedback. OSTEs support their professional identity development regarding learning and teaching while sustaining faculty development.
Breast Cancer: Epidemiology and Risk Factors

Breast cancer is a worldwide problem affecting more than 1 million women annually. Currently, best care for women with breast cancer involves a multidisciplinary approach requiring a broad understanding of epidemiologic, genetic, prognostic, and predictive factors. This study will discuss the epidemiology and risk factors associated with breast cancer.
Integrin Cytoplasmic Tail Interactions

Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival. Here, we review key integrin-interacting proteins and their roles in regulating integrin activity, localization, and signaling.
A Coding Scheme to Support Systematic Analysis of Software Comprehension

Protocol analysis is a valuable tool for gaining qualitative data from observations of programmer behaviour during software maintenance. However, there are some major drawbacks with protocol analysis as it is currently practiced. Firstly, protocol analysis requires a daunting amount of effort at each stage of analysis. Secondly, the results from one protocol analysis are often difficult to compare with results from another. The paper describes a coding scheme, AFECS, designed to reduce the effort required to perform protocol analysis and to resolve the problem of noncomparable results. AFECS uses codes that consist of expandable and flexible segments. This allows AFECS to be tailored to the requirements of a variety of research studies, while maintaining a degree of consistency. Explicit segmentation also makes AFECS easy to use. An example shows AFECS' use and ability to adapt to diverse research questions.