Miracle-dz/UniFAR-FTUs huggingface dataset:
A Service-Oriented Operating System and an Application Development Infrastructure for Distributed Embedded Systems

The paradigm of service-orientation promises a significant ease of use in creating and managing distributed software systems. A very important aspect here is that also application domain experts and stakeholders, who are not necessarily skilled in computer programming, get a chance to create, analyze, and adapt distributed applications. However, up to now, service-oriented architectures have been mainly discussed in the context of complex business applications. In this paper we will investigate how to transfer the benefits of a service-oriented architecture into the field of embedded systems, so that this technology gets accessible to a much wider range of users. As an example, we will demonstrate this scheme for sensor network applications. In order to address the problem of limited device resources we will introduce a minimal operating system for such devices. It organizes all pieces of code running on a sensor node in a service-oriented fashion and also features the relocation of code to a different node at runtime. We will demonstrate that it is possible to design a sensor network application from a set of already existing services in a highly modular way by employing already existing technologies and standards.
24 and 48 h allergen exposure in patch testing

Patch test reactions to 11 common contact allergens were studied after 24 h and 48 h occlusion with Finn Chambers in 390 patients. Concordant allergic results were found in 96 cases (74%). In 22 patients (17%), the reaction was positive only after 48 hand in 11 cases (8.5%) only after 24 h exposure. Most of the discordant reactions were to nickel, cobalt, neomycin, formaldehyde and perfume mix. Irritant reactions were found in 55 cases, the majority occurring after 48 h occlusion. Nickel chloride tested in parallel with 48 h exposure lead to more positive allergic and toxic reactions than nickel sulphate.
Energy-Aware Scheduling of Real-Time Heterogeneous Multiprocessor Systems-ona-Chip

In this paper an off line energy-aware algorithm is presented for the case of heterogeneous multiprocessor systems-on-a-chip. Threads are divided in precedence-related tasks that should execute on specific processors. A voltage scaling technique is used to reduce the power demand of the processors, each of which operates at a single frequency.
Incorporation of a physically based melt pond scheme into the sea ice component of a climate model

The extent and thickness of the Arctic sea ice cover has decreased dramatically in the past few decades with minima in sea ice extent in September 2005 and 2007. These minima have not been predicted in the IPCC AR4 report, suggesting that the sea ice component of climate models should more realistically represent the processes controlling the sea ice mass balance. One of the processes poorly represented in sea ice models is the formation and evolution of melt ponds. Melt ponds accumulate on the surface of sea ice from snow and sea ice melt and their presence reduces the albedo of the ice cover, leading to further melt. Toward the end of the melt season, melt ponds cover up to 50% of the sea ice surface. We have developed a melt pond evolution theory. Here, we have incorporated this melt pond theory into the Los Alamos CICE sea ice model, which has required us to include the refreezing of melt ponds. We present results showing that the presence, or otherwise, of a representation of melt ponds has a significant effect on the predicted sea ice thickness and extent. We also present a sensitivity study to uncertainty in the sea ice permeability, number of thickness categories in the model representation, meltwater redistribution scheme, and pond albedo. We conclude with a recommendation that our melt pond scheme is included in sea ice models, and the number of thickness categories should be increased and concentrated at lower thicknesses.
Age‐related changes in susceptibility of rat brain slice cultures including hippocampus to encephalomyocarditis virus

Replication of the D variant of encephalomyocarditis virus (EMC‐D) and its cytopathic effects were studied in the brain slice cultures including hippocampus (hippocampal slice) obtained from postnatal 1‐, 4‐, 7‐, 14‐, 28‐and 56‐day‐old Fischer 344 rats. At 0, 12, 24, 36 and 48 h after infection, virus titres of the slices and culture media were assayed. Viral replication was observed in cultures from 1‐to 28‐day‐old rats, and the highest titre was recorded in the slice and culture medium from the youngest rat. The peak of virus titre decreased with age and no distinct viral replication was observed in the cultures from 56‐day‐old rats. Light microscopy revealed that degenerative and necrotic changes appeared in the infected hippocampal slices from 1‐ to 28‐day‐old rats, and the changes became less prominent with age. In situ hybridization and indirect immunofluorescence staining showed that positive signals of viral RNA and antigen were prominent in younger rats and decreased with age. These results suggest that an age‐related decrease in the susceptibility of rat brain to EMC‐D is less related to the maturation of the immune system but possibly to that of the neurone.
Intuition: The New Frontier of Management

Preface. 1. Intuition in Context. 2. The Role of Intuition in Management. 3. Defining Intuition. 4. Refining Intuition: Accessing and Enhancing. 5. Vision and Visioning. 6. The Practice of Visioning (the P. N. Model). 7. Global Intuition Survey Report. 8. Inter--Country Intuition Survey Report. 9. Intuitive Leadership. Appendices.
SUZAKU MONITORING OF THE SEYFERT 1 GALAXY NGC 5548: WARM ABSORBER LOCATION AND ITS IMPLICATION FOR COSMIC FEEDBACK

We present a 2 month Suzaku X-ray monitoring of the Seyfert 1 galaxy NGC 5548. The campaign consists of seven observations (with exposure time of ∼30 ks each), separated by ∼1 week. This paper focus on the X-ray Imaging Spectrometer data of NGC 5548. We analyze the response in the opacity of the gas that forms the well-known ionized absorber in this source for ionizing flux variations. Despite variations by a factor of ∼4 in the impinging continuum, the soft X-ray spectra of the source show little spectral variations, suggesting no response from the ionized absorber. A detailed time modeling of the spectra confirms the lack of opacity variations for an absorbing component with high ionization (UX ≈ −0.85), and high outflow velocity (vout ≈ 1040 km s−1), as the ionization parameter was found to be consistent with a constant value during the whole campaign. Instead, the models suggest that the ionization parameter of a low ionization (UX ≈ −2.8), low velocity (vout ≈ 590 km s−1) absorbing component might be changing linearly with the ionizing flux, as expected for gas in photoionization equilibrium. However, given the lack of spectral variations among observations, we consider the variations in this component as tentative. Using the lack of variations, we set an upper limit of ne < 2.0 × 107 cm−3 for the electron density of the gas forming the high ionization, high velocity component. This implies a large distance from the continuum source (R>0.033 pc; R>5000RS). If the variations in the low ionization, low velocity component are real, they imply ne>9.8 × 104 cm−3 and R < 3 pc. We discuss our results in terms of two different scenarios: a large-scale outflow originating in the inner parts of the accretion disk, or a thermally driven wind originating much farther out. Given the large distance of the wind, the implied mass outflow rate is also large ( 0.08 \dot{M}_{\rm accr}$? >; the mass outflow is dominated by the high ionization component). The associated total kinetic energy deployed by the wind in the host galaxy (>1.2 × 1056 erg) can be enough to disrupt the interstellar medium, possibly quenching or regulating large-scale star formation. However, the total mass and energy ejected by the wind may still be lower than the one required for cosmic feedback, even when extrapolated to quasar luminosities. Such feedback would require that we are observing the wind before it is fully accelerated.
Research on half-mesh topology based on binary model and HTF-XY routing algorithm

Researches on network-on-chip NoC topology are ongoing in 2-dimensional or 3-dimensional space. However, for the current topology in 2-dimensional space, the long communications delay is the biggest problem; while, for the topology in 3-dimensional space, high complexity of the routing algorithm and difficulty of physical implementation cannot be solved. Therefore, we propose a novel kind of topology named half-mesh. The half-mesh introduces binary search, and based on mesh, processing unit in system central as an original point, along the X, Y direction, respectively, increases the head nodes and intermediate nodes. Therefore, it shortens the path length between nodes, and ensures the diversity of paths. As to half-mesh structure, we put forward to half-test-feedback-XY HTF-XY. According to the area where the destination node lies, we adopt a different routing strategy to achieve minimum latency between routers. Theoretical analysis and experimental results show that half-mesh structure, compared with the mesh and torus, has the advantage of short routing path, throughput, and load balancing.
Inhibition of Phosphatidylinositol-4-phosphate 5-Kinase Iα Impairs Localized Actin Remodeling and Suppresses Phagocytosis*

Actin polymerization drives the extension of pseudopods required for phagocytosis. Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a central role in this process, because it interacts with several actin-regulatory proteins and undergoes acute and localized changes at sites of phagocytosis. We therefore studied whether phosphatidylinositol-4-phosphate 5-kinase (PIPK), the enzyme responsible for the generation of PIP2from phosphatidylinositol 4-phosphate, is involved in the control of phagocytosis. PIPKIα was found to accumulate transiently on forming phagosomes. To test the functional involvement of PIPKIα in particle engulfment, we generated a double mutant (D309N/R427Q) that lacks kinase activity. When ectopically expressed in cultured cells, this mutant is targeted to the plasma membrane and accumulates at the phagosomal cup during particle engulfment. Expression of PIP5KIα D309N/R427Q impaired phagocytosis in RAW264.7 macrophages and in engineered phagocytes generated by transfection of Fc receptors in Chinese hamster ovary cells. Inhibition of phagocytosis could not be attributed to defects in particle binding or receptor clustering, which was monitored using green fluorescent protein-tagged Fcγ receptors. Instead, expression of the inactive kinase diminished the accumulation of PIP2 and of F-actin in the phagosomal cup. These data suggest that PIPKIα activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIα appears to contribute to the transient changes in PIP2 levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins.
Secrecy in the 2-user symmetric deterministic interference channel with transmitter cooperation

This work presents novel achievable schemes for the 2-user symmetric linear deterministic interference channel with limited-rate transmitter cooperation and perfect secrecy constraints at the receivers. The proposed achievable scheme consists of a combination of interference cancelation, relaying of the other user's data bits, time sharing, and transmission of random bits, depending on the rate of the cooperative link and the relative strengths of the signal and the interference. The results show, for example, that the proposed scheme achieves the same rate as the capacity without the secrecy constraints, in the initial part of the weak interference regime. Also, sharing random bits through the cooperative link can achieve a higher secrecy rate compared to sharing data bits, in the very high interference regime. The results highlight the importance of limited transmitter cooperation in facilitating secure communications over 2-user interference channels.
Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion–Positive Cancer

Purpose: ROS1 rearrangement leads to constitutive ROS1 activation with potent transforming activity. In an ongoing phase I trial, the ALK tyrosine kinase inhibitor (TKI) crizotinib shows remarkable initial responses in patients with non–small cell lung cancer (NSCLC) harboring ROS1 fusions; however, cancers eventually develop crizotinib resistance due to acquired mutations such as G2032R in ROS1. Thus, understanding the crizotinib-resistance mechanisms in ROS1-rearranged NSCLC and identification of therapeutic strategies to overcome the resistance are required. Experimental Design: The sensitivity of CD74–ROS1–transformed Ba/F3 cells to multiple ALK inhibitors was examined. Acquired ROS1 inhibitor–resistant mutations in CD74–ROS1 fusion were screened by N-ethyl-N-nitrosourea mutagenesis with Ba/F3 cells. To overcome the resistance mutation, we performed high-throughput drug screening with small-molecular inhibitors and anticancer drugs used in clinical practice or being currently tested in clinical trials. The effect of the identified drug was assessed in the CD74–ROS1–mutant Ba/F3 cells and crizotinib-resistant patient-derived cancer cells (MGH047) harboring G2032R-mutated CD74–ROS1. Results: We identified multiple novel crizotinib-resistance mutations in the ROS1 kinase domain, including the G2032R mutation. As the result of high-throughput drug screening, we found that the cMET/RET/VEGFR inhibitor cabozantinib (XL184) effectively inhibited the survival of CD74–ROS1 wild-type (WT) and resistant mutants harboring Ba/F3 and MGH047 cells. Furthermore, cabozantinib could overcome all the resistance by all newly identified secondary mutations. Conclusions: We developed a comprehensive model of acquired resistance to ROS1 inhibitors in NSCLC with ROS1 rearrangement and identified cabozantinib as a therapeutic strategy to overcome the resistance. Clin Cancer Res; 21(1); 166–74. ©2014 AACR.
Bullying and harassment and work-related stressors: Evidence from British small and medium enterprises

This article examines the relationship between work-related stressors and bullying and harassment in British small and medium sized enterprises (SMEs). Using representative data from a national survey on employment rights and experiences (Fair Treatment at Work), this research identifies that bullying and harassment are just as prevalent in British SMEs as in larger organisations. Drawing upon the Management Standards of the Health and Safety Executive, a number of significant relationships with bullying and harassment are established. Work demands placed upon employees are positively related to bullying and harassment behaviours, while autonomy, manager support, peer support and clarity of role are negatively associated with such behaviours. The study considers implications for human resource practices in SMEs, and the risks of informal attitudes to these work-related stressors in contemporary workplaces are discussed.
15.2 A 0.012mm2 3.1mW bang-bang digital fractional-N PLL with a power-supply-noise cancellation technique and a walking-one-phase-selection fractional frequency divider

Digital phase-locked loops (DPLLs) [1-7] have received considerable attention recently due to their compatibility with advanced CMOS technology. However, there are two critical factors hindering their uptake in SoC products. One factor is that a digitally controlled oscillator (DCO) is highly sensitive to supply noise. A common solution is to apply voltage regulation or to adopt digital calibration [2] at the cost of larger area, higher power consumption or both. The other factor is a power-hungry time-to-digital converter (TDC), which typically requires complex auxiliary circuitry to overcome sensitivity to process, voltage and temperature [3]. A bang-bang phase/frequency detector (BBPFD) is a good alternative to the TDC for low-power small-size applications. A fractional-N implementation, however, still demands a fractional frequency divider with high design complexity [5]. This paper presents a bang-bang all-digital fractional-N PLL, which occupies a small area, consumes low power and addresses the aforementioned issues. A block diagram of the fractional-N DPLL is shown in Fig. 15.2. 1. An automatic frequency controller (AFC) tunes a DCO frequency in the foreground for fast locking. The DCO employs a supply-noise canceling architecture to address the power supply noise issue with negligible power and area overhead. We adopt a phase-interpolator-based fractional divider controlled by a walking-one phase selector for low power and compactness.
Duale Ausbildung und Personalpolitik: So gleich und doch so fremd?

Im Rahmen des Artikels wird argumentiert, dass die institutionellen Rahmenbedingungen dazu fuhren, dass Schweizer Unternehmen - im Vergleich zu deutschen - in geringerem Ausmas auf ihre eigenen Lehrlinge zuruckgreifen, wenn es darum geht, freie Facharbeiterstellen in der Produktion zu decken.
Chromosomal Abnormalities and Dyserythropoiesis in the Preleukaemic Phase of Multiple Myeloma

Two patients with multiple myeloma and one patient with a plasmacytoma are reported in whom acute leukaemia developed following long‐term treatment with melphalan. Each patient had a complete remission of the plasma cell disorder during which time the bone marrow was moderately to severely hypplastic. The end of the clinical remission was heralded by a dyserythropoietic anaemia which persisted several months before the emergence of the terminal acute leukaemia. Marked chromosomal abnormalities were observed in marrow cells during the dyserythropoietic phase.
Skeleton-based modeling operations on solids

The skeleton is a lower-dimensional geometric abstraction that is useful for performing a number of important geometric operations on solid models. In this paper we develop skeleton-based algorithms that demonstrat,e the utility of the skeleton in addressing: (1) 1 evel-of-detail control, the generation of hierarchical representations that preserve overall shape but blur local boundary features; (2) hexahedral mesh generation, the decomposit,ion of a 3D shape into a collection of block elements suitable for finite element analysis; (3) shape interpolation and morphing, the generation of an “int>ermediate” shape from two given 3D shapes and the generation of a sequence of shapes that smoothly transform one shape into another; and (4) shape synthesis, the generation of an optimal shape from specifications of functional performance requirements and constraints. Besides our goal of providing novel solutions to these problems of significant, practical importance, we seek to illustrate the general usefulness of the skeleton as an intermediate geometric descrig tion that should be more widely implemented in commercial CAD systems.
Observation Time vs. Performance in Digital Phenotyping

Mobile health (mHealth) technologies enable frequent sampling of physiological and psychological signals over time. In our recent work we used a convolutional neural network (CNN) model to predict self-reported phenotypes of chronic conditions from step and sleep data recorded from passive trackers in free living conditions. We investigated the impact of the time-granularity of the collected data and showed that training the models on higher- resolution (minute-level) data improved classification performance on conditions related to mental health and nervous system disorders, as compared to using only day-level totals. In the present work we shift the focus from the time resolution of the observation window to its duration. We study how the performance of the best-performing model on the highest-resolution data changes as the length of the data collection window is varied from 3 to 147 days for each user. We found that for mental health and nervous system disorders, a model trained on 30 days of mHealth data attains the same performance as using the full 147-day window of data, in terms of AUC increase over a baseline model that uses only demographics, height, and weight. Additionally, for the same cluster of conditions, only 7 days of data are sufficient to realize 62% of the maximum increase in AUC over baseline attainable using the full window. The results suggest that for some conditions health-related digital phenotyping in free-living conditions can potentially be performed in a relatively short amount of time, imposing minimal disruptions on user habits.
Signal processing approach towards designing ultra-low power transceivers

We propose an ultra-low power transceiver used as a wake-up radio, to detect a beacon signal transmitted from an access point and subsequently enable the rest of the transceiver chain. However, such ultra low-power radios suffer from poor sensitivity due to noise. The objective of this paper is to model such RF samplers and understand the signal processing in Rx chains. Based on this model, we propose optimal signal shaping techniques and achieve significant improvements noise sensitivity. Finally, we derive the performance bounds of such transceivers and show the convergence of optimal signal shaping techniques with that of ideal transceivers under Gaussian noise.
Handbook of psychosocial interventions with older adults : evidence-based approaches

Preface Barbara Berkman 1 Overview of Evidence-Based Practice with Older Adults and their Families Sherry M. Cummings and Nancy P. Kropf EVIDENCE-BASED INTERVENTIONS FOR HEALTH CONDITIONS 2 Cardiac Conditions Michel D. Peck and Amy L. Ai 3 Cancer Treatments Peter Maramaldi, Sheryn Dungan and Nancy Levitan Poorvu 4 Arthritis Pain Eunkyung Yoon and John B. Doherty 5 Diabetes Treatments Vaughn A. DeCoster 6 HIV/AIDS Treatments Charles A. Emlet and R. Andrew Shippy EVIDENCE-BASED INTERVENTIONS FOR COGNITIVE AND MENTAL HEALTH ISSUES 7 Depression and Anxiety Margaret E. Adamek and Greta Yoder Slater 8 Alzheimer's Disease and Related Dementias Sara Sanders and Carmen Morano 9 Substance Abuse Sherry M. Cummings, Brian Bride, Kimberly McClure Cassie and Ann Rawlins-Shaw EVIDENCE -BASED INTERVENTIONS FOR SOCIAL FUNCTIONING 10 Individuals with Developmental Disabilities and their Caregivers Philip McCallion and Tara Nickle 11 Treatment at the End of Life Deborah P. Waldrop 12 Familial Caregivers of Older Adults Kimberly McClure Cassie and Sara Sanders 13 Grandparent Caregivers Stacey Kolomer 14 Evidence-Based Interventions with Older Adults: Concluding Thoughts Nancy P. Kropf and Sherry M. Cummings
Space-time Tradeoos in Memory Hierarchies

The speed of CPUs is accelerating rapidly, outstripping that of peripheral storage devices and making it increasingly di cult to keep CPUs busy. Multilevel memory hierarchies, scaled to simulate single-level memories, are increasing in importance. In this paper we introduce the Memory Hierarchy Game, a multi-level pebble game simulating data movement in memory hierarchies for straight-line computations. This game provides a framework for deriving upper and lower bounds on computation time and the I/O time at each level in a memory hierarchy. We apply this framework to a representative set of problems including matrix multiplication and the Fourier transform. We also discuss conditions on hierarchies under which they act as fast at memories. This work was supported in part by the O ce of Naval Research under contract N00014-91-J4052, ARPA Order 8225.