Miracle-dz/UniFAR-FTUs huggingface dataset:
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1491 Sentinel Node Biopsy for Breast Cancer Aspects and evolution

Karakatsanis, A. 2018. Sentinel Node Biopsy for Breast Cancer. Aspects and evolution. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1491. 78 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0423-6. Sentinel Node Biopsy (SNB) in clinical practice was pivotal to the shaping of modern diagnosis, staging and treatment of patients with breast cancer. The use of radioisotope (RI) and blue dye (BD) has led to high detection rates with low false negatives, but delivery-of-care limitations connected to these tracers as well as the need for methods addressing new clinical conundrums delineates the urge for new tracers with comparable performance, easier logistics and, ideally expanded implementations. Aim of the present thesis is to examine the outcomes of Superparamagnetic Iron Oxide (SPIO) nanoparticles, a new tracer based on magnetism for the detection of the sentinel nodes. Paper I is a prospective multicentre trial comparing SPIO to RI+BD, with all tracers injected at the same patient. In 206 patients, SPIO had a similar detection rate (97.6 vs 97.1%, p=0.76) whereas concordance between methods was 98%. The study was completed by a meta-analysis of similar trials published until that point. The detection rates were comparable (fixed OR:1.10; 0.67,1.79, p=0.71), and so was concordance between tracers (fixed RD: 0.00; -0.01, 0.01, p=0.82). Discoloration was present after periareolar SPIO injection in 39% of patients, almost exclusively treated with breast conservation, which reduced to 8.6% after 15 months of followup. Paper II was a pilot study of twelve patients with breast cancer and SNB performed where SPIO and the combination of RI+BD were injected, but SPIO was injected up to 15 days preoperatively, with total success in detection and complete concordance. Paper III tested the performance of SPIO as a sole tracer in a pragmatic double-arm nonrandomised trial comparing it to the combination of RI+BD. Detection was 95.7% for SPIO and 96.8% for RI (p = 0.59). The preoperative injection of SPIO (1-27 d) enhanced SPIO specific detection (95.7 vs 86%, p=0.002). Paper IV is an interim analysis of a multicentre cohort study including patients with high-risk DCIS planned for breast conservation or any DCIS planned for mastectomy. SPIO was injected to “mark” the sentinel node but SNB was performed in a second operation only if invasive cancer was found at the first operation. In 151 included patients, this technique led to avoidance of 81.5% SNB, with a cost reduction of 14.1% for the entire cohort and 25.8% for the patients that did not have invasive cancer. The detection rate at reoperation was superior for SPIO and comparable with SNB detection at primary operation. In conclusion, SPIO is a novel tracer for SNB in breast cancer with comparable performance, fit for performance in a global setting and with wider clinical implementations compared to RI +BD.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 262 Breastfeeding and Becoming a Mother Influences and Experiences of Mothers of Preterm Infants

I would like to dedicate this thesis to the mothers I have met, and to my children Johan, Anton and Nike On the cover Vincent, born after 30 weeks of gestation, is shown at 4 days of age, weighing 1400 grams and lying at his mother Sofia's breast. Photograph taken by Vincent's father Anders Östman. Printed by permission of the family. key to "becoming a mother" and to reciprocal breastfeeding. Stories of mothers of very preterm infants at a neonatal unit. I wanted to do a good job " : Experiences of 'becoming a mother' and breastfeeding in mothers of very preterm infants after discharge from a neonatal unit. (Soc Sci Med, in press) III. Flacking R, Hedberg Nyqvist K, Ewald U. Effects of socioeconomic status on breastfeeding duration in mothers of preterm and term infants. determinants of breastfeeding duration in very preterm infants. (submitted) Papers I-III are reprinted with the permission of the publishers.
Intelligent Layout Method of Power Line

In order to better solve the problems of low efficiency, error prone and low reusability along the line, this solution provides an idea to solve this problem by automatically analyzing the planning rules. Planning rules refer to various influencing factors that need to be considered during route drawing. Through the definition of rules, rules are used to guide the drawing of lines. Through the automatic analysis of the program and the application of rules, the efficiency of lines along the cloth can be greatly improved. First, you can define common avoidance rules and follow rules in the rule definition function as required, and support intelligent definition, so as to meet the requirements of modifying rule details through parameter configuration. Nest, through the rule customization technology, when the line is laid along, the user-defined rules are applied to judge the line along the layout, and the rule items are used to replace the manual judgment to achieve the high efficiency and accuracy of the line along the layout.
A Multi-exposure Images Fusion Approach for Very Large Dynamic Range Scenes

The exposure fusion technique is very useful for directly fusing multi-exposure images into a high quality image, without the physically based high dynamic range (HDR) production step. In this paper, we present an improved method for multi-exposure images fusion using multi-resolution Laplacian pyramid weighted blending. We propose a Weight Modification Factor (WMF) to modify the original weight map for each image guided by contrast, saturation and well-exposedness of each pixel in the image, and to enhance the weight of the informative pixels in ultra-bright or ultra-dark areas. Compared with previous methods, our approach preserves more useful details for scenes with very large dynamic range and achieves no artifacts. Several objective quality metrics prove the advantages of our method.
Analysis of Multi‐angle Imaging SpectroRadiometer (MISR) aerosol optical depths over greater India during winter 2001–2004

We present the first detailed spatial analysis of a four‐year, wintertime visible aerosol optical depth (AOD) climatology from the Multi‐angle Imaging SpectroRadiometer (MISR) over greater India. Meteorological fields from the National Centers for Environmental Prediction (NCEP) reanalysis, topographic data, and information related to aerosol source regions are used to explain the spatial patterns in MISR AODs. High AODs are found over much of greater India. The highest AODs are over the northern Indian state of Bihar, where we show that meteorology, topography, and aerosol sources all favor development of a concentrated pool of airborne particles. MISR AODs are validated against five ground‐based sites in India and Nepal, revealing similar error characteristics found in other validation studies for the MISR aerosol product.
Hydrological properties of canopy of acacia in loess hilly and gully region

The rainfall was redistributed into canopy interception, through-fall and stem-flow when it went through the canopy because of canopy interception. In loess hilly and gully region of northern of Shaanxi province, rainfall in southeastward and northeastward acacia woodlands(Robinia pseudoacacia L.) was observed in growth stages.The hydrological properties of forest canopy were analyzed. The results showed that the correlativity among through-fall quantity, stem-flow quantity and precipitation were parabola.The correlativity between interception quantity and precipitation was Mitscherlich. The correlativity among through-fall ratio, stem flow ratio and precipitation were exponential function.The correlativity between interception ratio and precipitation was power function.The amount of interception, through-fall and stem-flow respectively accounted for 80.39%—89.19%, 2.31%—2.62%, 8.51%—16.99% of precipitation.The through-fall ratio and stem flow ratio increased with the increase of precipitation.The interception ratio decreased with the increase of precipitation. The interception ratio varied very slowly and was close to a constant value after forest canopy was saturated. The laws on interception quantity, through-fall quantity and stem-flow quantity with season variation were consistent.It was seen that they were high from Jun.to Sept.and low in May or Oct.The though-fall ratio was also high from Jun.to Sept.and low in May or Oct.The stem-flow ratio doesn’t vary obviously with season because it was too little. However, the interception ratio was low in rainy season and high in rainless season.The studies on hydrological property of acacia canopy and quantization of redistribution to rainfall by canopy could provide scientific evidences.They were useful for researches to investigate water cycle and transfer in soil-vegetation-atmosphere system and make optimal utilization of water resources in loess hilly and gully region.
HEAT FLOW IN A “BLIND” GEOTHERMAL AREA NEAR MARYSVILLE, MONTANA

A unique geothermal area has been discovered during the course of a regional heat‐flow study using holes drilled for mineral exploration. There are no surface manifestations of abnormal subsurface temperature in spite of the fact that at one locality a temperature of 58°C was measured at a depth of only 220 m. The area of anomalous heat flow straddles the Continental Divide near the old gold mining camp of Marysville, Montana about 30 km northwest of Helena. Measured values of conducted heat flow range from 3.2 to 19. 5μcal/cm2 sec. The immediate source of the high heat flow is either an unexposed reservoir of thermal fluids or a very shallow still‐cooling magma chamber. At the present time the magma chamber model is preferred. The presence of additional similar areas in the western U.S. is suggested by the data from regional heat‐flow studies. However, in most of the other areas only single anomalous heat‐flow value is available, whereas at Marysville a region of several tens of km2 is known to have abnor.
Visual Navigation Systems Implementation Using Hybrid Convolutional Neural Networks

This paper presents a comprehensive assessment of contemporary uses for navigation algorithms. Based on the results of investigation, deficiencies in the algorithms were uncovered, application of hybrid convolutional neural networks was proposed. In this paper conducted a qualitative examination of contemporary architectures of convolutional neural networks, structural components and highlighted their individual limitations at use in systems on the basis of aircraft hardware.
IoT-Based Automatic Room Lighting System

This study addresses the imperative of sustainable development by focusing on efficient electricity utilization, aligning with UN Sustainable Development Goal 7. The goal seeks universal access to affordable, reliable, sustainable, and contemporary energy sources for all individuals. An investigation into automated home lighting systems is conducted, aiming to achieve energy efficiency. Control of the lighting system is vested in a central controller, the NodeMCU, equipped with Wi-Fi, and connected to two ultrasonic sensors and a light-dependent resistor (LDR). Illumination is initiated exclusively under conditions of darkness with the presence of occupants. This technology facilitates remote lighting control via a mobile phone and allows for energy conservation during prolonged absences. The mobile application offers versatile functionalities, allowing users to switch between manual and automatic lighting control modes while monitoring real-time lighting status and occupancy count. In manual mode, users can directly adjust lighting regardless of conditions and reset the occupancy counter when needed. These features empower users to enhance energy efficiency and safety within their spaces. Besides energy conservation and domestic safety, the study's implications extend to user convenience, and the integration of technology into sustainable and secure home environments, all of which have potential far-reaching benefits for homeowners and society at large.
Sedentary behavior, abdominal obesity and healthcare costs in Brazilian adults with cardiovascular diseases: a cross-sectional study

ABSTRACT BACKGROUND: Research on the economic burden of sedentary behavior and abdominal obesity on health expenses associated with cardiovascular diseases is scarce. OBJECTIVE: The objective of this study was to verify whether sedentary behavior, isolated and combined with abdominal obesity, influences the medication expenditure among adults with cardiovascular diseases. DESIGN AND SETTING: This cross-sectional study was conducted in the city of President Prudente, State of São Paulo, Brazil in 2018. METHODS: The study included adults with cardiovascular diseases, aged 30-65 years, who were treated by the Brazilian National Health Services. Sedentary behavior was assessed using a questionnaire. Abdominal obesity was defined by waist circumference. Medication expenditures were verified using the medical records of each patient. RESULTS: The study included a total of 307 adults. Individuals classified in the group with risk factor obesity combined (median [IQ] USD$ 29.39 [45.77]) or isolated (median [IQ] USD$ 27.17 [59.76]) to sedentary behavior had higher medication expenditures than those belonging to the non-obese with low sedentary behavior group (median [IQ] USD$ 13.51 [31.42]) (P = 0.01). The group with combined obesity and sedentary behavior was 2.4 (95%CI = 1.00; 5.79) times more likely to be hypertensive. CONCLUSION: Abdominal obesity was a determining factor for medication expenses, regardless of sedentary behavior, among adults with cardiovascular diseases.
BOISE STATE UNIVERSITY GRADUATE COLLEGE DEFENSE COMMITTEE AND FINAL READING APPROVALS

vi LIST OF TABLES . x LIST OF FIGURES . xi LIST OF ABBREVIATIONS . xii CHAPTER ONE: INTRODUCTION . 1 Background . 1 Research Questions . 5 Thesis Statement . 7 CHAPTER TWO: RELATED WORK . 9 Single Screen Data Visualization Systems . 10 Systems Using Large Format Display . 12 CHAPTER THREE: IMPLEMENTED SYSTEM . 15 Client Side Components . 17 HDLF Display . 17 Data-Driven Documents Package . 18 View Initializer . 20 WebSocket Server . 21
Design Guide for CMOS Process On-Chip 3D Inductor using Thru-Wafer Vias

Three-dimensional (3D) inductors using high aspect ratio (10:1) thru-wafer via (TWV) technology in a complementary metal oxide semiconductor (CMOS) process have been designed, fabricated, and measured. The inductors were designed using 500μm tall vias with the number of turns ranging from 1 to 20 in both a wide and narrow trace width to space ratios. Radio frequency characterization was studied with emphasis upon de-embedding techniques and resulting effects. The open, short, thru de-embedding (OSTD) technique was used to measure all devices. The highest quality factor (Q) measured was 11.25 at 798MHz for a 1-turn device with a self-resonant frequency (fsr) of 4.4GHz. The largest inductance (L) measured was 45nH on a 20-turn wide trace device with a maximum Q of 4.25 at 732MHz. A 40% reduction in area is achieved by exploiting the TWV technology when compared to planar devices. This technology shows promising results with further development and optimization.
BOISE STATE UNIVERSITY GRADUATE COLLEGE DEFENSE COMMITTEE AND FINAL READING APPROVALS

vi LIST OF TABLES . x LIST OF FIGURES . xi LIST OF ABBREVIATIONS . xiii CHAPTER ONE: INTRODUCTION . 1 Parasites . 1 Giardia intestinalis . 4 Entamoeba histolytica . 8 Methionine, SAM Reactions, and the Methionine Salvage Pathway . 10 Methylthioadenosine Nucleosidase (MTN): A New Drug Target . 14 In-silico Computational Drug Discovery . 22 Summary . 26 CHAPTER TWO: MATERIALS AND METHODS . 27 Induction and Purification of Recombinant Enzymes . 27 Analysis of MTN and MTAP Proteins . 28 Determination of Protein Concentration . 29 MTN Activity: Enzyme Assays . 29
A numerical investigation of freshwater and sediment discharge variations of Poyang Lake catchment, China over the last 1000 years

The Poyang Lake catchment, an important sub-catchment of Changjiang, experienced ‘Little Ice Age’ (LIA) and accelerating intensity of human activities during the last 1000 years. As such, the area and time period serve as a perfect case to study the variations in water and sediment discharge under combined natural and anthropogenic impact. Simulation results of the model HydroTrend indicate that the annual average cumulative water discharge of the five rivers entering Poyang Lake over the last 1000 years is 103.65 ± 1.80 km3, and climate change is the dominating factor determining water discharge variations over time. Influenced by the LIA (AD 1451–1850), the total water discharge of the five rivers was reduced by 10%. Sediment load discharging into Poyang Lake by the five rivers was only 9.21 ± 0.43 Mt yr−1 between AD 1000 and 1700, when the anthropogenic impact on the landscape was still low. However, with the human activities accelerating during the past 300 years, the sediment load entering Poyang Lake underwent a drastic change. Because of intensified soil loss, the total sediment load entering Poyang Lake during AD 1800–1950 increased by 58.7%, compared with AD 1000–1700. After AD 1950, the sediment load variation is mainly reflected by the combined impact of dam emplacement and soil erosion. As sediment interception by dams continuously increased over time, the total sediment load entering Poyang Lake during AD 1990–2000 is only 60.9% of that of the highest riverine sediment flux during AD 1951–1980, which is almost equal to that of the lowest level during AD 1000–1700. The sediment load of many rivers in the world exhibited similar variation trends as that of Poyang Lake under combined impact of climate change and human activities. Better understanding the mechanisms of these variation trends is helpful to analyzing the formation and evolution of an estuary-shelf sedimentary system over the Holocene.
Characteristics of drought in the arid region of northwestern China

Drought evolution from 1960 to 2010 and its teleconnections were analyzed by utilizing the monthly Standardized Precipitation Evapotranspiration Index (SPEI) in the arid region of northwestern China. To assess the temporal pattern of drought as multi-scalar events, the SPEI was calculated for short-term (1 and 3 mo), medium-term (6 and 12 mo), and long-term droughts (24 and 48 mo). The results showed (1) step changes occurred in 1986; droughts occurred frequently before 1986, and wet periods prevailed after 1986. Generally, the period of 1973−1983 showed the highest drought activity, while 1993−1998 showed the lowest. (2) Annual and seasonal SPEI demonstrated significant upward trends, especially for the stations around the Tarim River Basin, implying that the study area had become wetter. (3) Interannual periods and decadal periods were observed for the whole study area and sub-regions. Moreover, patterns of period characteristics became more apparent at longer time scales. (4) The Indian Ocean Basin-Wide mode (IOBW) and Pacific Decadal Oscillation (PDO) may be the dominant forces, with the largest correlation coefficients in the whole study area. For the Xinjiang region, the simultaneous Arctic Oscillation (AO) and North Atlantic Oscillation (NAO) play an important role in drought evolution, especially from January to March. Lag times between climate indices and SPEI may exist in this arid region, and current droughts may be affected by the preceding climate indices.
Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma

Progesterone Receptor Membrane Component 1 (PGRMC1) is a tumour-promoting factor in several types of cancer but its role in brain tumours is poorly characterized thus far. Our study aimed to determine the effect of PGRMC1 on glioblastoma (GBM) pathophysiology using two independent cohorts of IDH wild-type GBM patients and stable knockdown GBM models. We found that high levels of PGRMC1 significantly predicted poor overall survival in both cohorts of GBM patients. PGRMC1 promoted the proliferation, anchorage-independent growth, and invasion of GBM cells. We identified Integrin beta-1 (ITGB1) and TCF 1/7 as potential members of the PGRMC1 pathway in vitro. The levels of ITGB1 and PGRMC1 also correlated in neoplastic tissues from GBM patients. High expression of PGRMC1 rendered GBM cells less susceptible to the standard GBM chemotherapeutic agent temozolomide but more susceptible to the ferroptosis inducer erastin. Finally, PGRMC1 enhanced Interleukin-8 production in GBM cells and promoted the recruitment of neutrophils. The expression of PGRMC1 significantly correlated with the numbers of tumour-infiltrating neutrophils also in tissues from GBM patients. In conclusion, PGRMC1 enhances tumour-related inflammation and promotes the progression of GBM. However, PGRMC1 might be a promising target for novel therapeutic strategies using ferroptosis inducers in this type of cancer.
Association for the Advancement of Artificial Intelligence

The undersigned, desiring to publish the above Work in a publication of the Association for the Advancement of Artificial Intelligence (AAAI), hereby hereby grants to the Association for the Advancement of Artificial Intelligence the following nonexclusive rights: (1) The nonexclusive world rights to use the above-named Work as part of an AAAI publication, in all languages and for all editions. (2) The right to use the Work, together with the author's name(s) and the editor’s name(s) and their pertinent biographical data, in advertising and promotion of it and the AAAI publication. (3) The right to publish or cause to be published the Work in connection with any republication of the AAAI publication in any medium including electronic.
SPECIAL COLLECTION: TECHNOLOGY IN A TIME OF SOCIAL DISTANCING Virtual Work Communication During a Pandemic — The Moderating Effect of Technology Expertise on Technology Overload

The coronavirus disease (COVID-19) pandemic and its accompanying restrictive measures have led to a sudden digitalization of all areas of work and to many knowledge workers now working entirely from home. Especially, the use of information and communication technologies (ICT) has been associated with negative outcomes such as technology overload. Interacting with technologyis dynamicandemployeesoftenhavetoface negativeICTeventsthatarerelatedtothetechnology ’ scharacteristics(e.g., system reliability). In this preregistered study, we aimed to link ICT events with employees ’ technology overload during a phase of intensive telework. In a daily diary study over the course of 2 weeks, we investigated how ICT events impact technology overload. Additionally, we explored how technology overload as well as professional isolation due to current pandemic-related restrictions impacts employee strain. Multilevel regression modeling was used to explore the described relationships. ICT events were a signi ﬁ cant predictor of technology overload and a signi ﬁ cant interaction effect of objective technology expertise was found. Technology overload further impacts ICT-related strain. No signi ﬁ cant effects were found regarding professional isolation. Gaining a better understanding of the relationship between ICT events, technology overload, and technology expertise during a phase of extensive telework will help to develop training and support for employees to improve their interaction with virtual communication systems during times of social distancing and beyond.