Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence and Growth of Patent Thickets: The Impact of Technological Opportunities and Complexity

We investigate incidence and evolution of patent thickets. Our empirical analysis is based on a theoretical model of patenting in complex and discrete technologies. The model captures how competition for patent portfolios and complementarity of patents affect patenting incentives. We show that lower technological opportunities increase patenting incentives in complex technologies while they decrease incentives in discrete technologies. Also, more competitors increase patenting incentives in complex technologies and reduce them in discrete technologies. To test these predictions a new measure of the density of patent thickets is introduced. European patent citations are used to construct measures of fragmentation and technological opportunity. Our empirical analysis is based on a panel capturing patenting behavior of 2074 firms in 30 technology areas over 15 years. GMM estimation results confirm the predictions of our theoretical model. The results show that patent thickets exist in 9 out of 30 technology areas. We find that decreased technological opportunities are a surprisingly strong driver of patent thicket growth.
A Learning Outcome-Oriented Approach towards Classifying Pervasive Games for Learning using Game Design Patterns and Contextual Information

Mobile and in particular pervasive games are a strong component of future scenarios for teaching and learning. Based on results from a previous review of practical papers, this work explores the educational potential of pervasive games for learning by analysing underlying game mechanisms. In order to determine and classify cognitive and affective learning outcomes, the authors propose employing game design patterns for mobile games and context information. Context information, in the course of this article, is introduced as an additional characteristic feature of mobile game design patterns. With the proposed framework the authors aim to understand how pervasive game content may support learning. Findings from their research indicate that context information directs the use and presentation of content within a game and thus influences learning effects of individual patterns. This work concludes with a discussion on the shortfalls and potentials, which the authors' framework for analysis provides.
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

How focal adhesions (FAs) convert retrograde filamentous actin (F-actin) flow into traction stress on the extracellular matrix to drive cell migration is unknown. Using combined traction force and fluorescent speckle microscopy, we observed a robust biphasic relationship between F-actin speed and traction force. F-actin speed is inversely related to traction stress near the cell edge where FAs are formed and F-actin motion is rapid. In contrast, larger FAs where the F-actin speed is low are marked by a direct relationship between F-actin speed and traction stress. We found that the biphasic switch is determined by a threshold F-actin speed of 8–10 nm/s, independent of changes in FA protein density, age, stress magnitude, assembly/disassembly status, or subcellular position induced by pleiotropic perturbations to Rho family guanosine triphosphatase signaling and myosin II activity. Thus, F-actin speed is a fundamental regulator of traction force at FAs during cell migration.
Anesthesia for tracheostomy for huge maxillofacial tumor

Providing sedation for patients with compromised upper airway is challenging. A 19-year-old female patient with huge maxillofacial tumor invading the whole pharynx scheduled for elective tracheostomy under local anesthesia due to compromised airway. The patient had gastrostomy tube for feeding. Venous cannulation was totally refused by the patient after repeated trials for exhausted sclerosed veins. Pre-operative mixture of dexmedetomidine with ketamine was administered through the gastrostomy tube with eutectic mixture of local anesthetics cream application over the planned tracheostomy site. The patient was sedated with eye opening to command. Local infiltration followed by tracheostomy was performed without patient complaints or recall of operative events.
Low frequency full waveform seismic inversion within a tree based Bayesian framework

S U M M A R Y Limited illumination, insufficient offset, noisy data and poor starting models can pose challenges for seismic full waveform inversion. We present an application of a tree based Bayesian inversion scheme which attempts to mitigate these problems by accounting for data uncertainty while using a mildly informative prior about subsurface structure. We sample the resulting posterior model distribution of compressional velocity using a trans-dimensional (trans-D) or Reversible Jump Markov chain Monte Carlo method in the wavelet transform domain of velocity. This allows us to attain rapid convergence to a stationary distribution of posterior models while requiring a limited number of wavelet coefficients to define a sampled model. Two synthetic, low frequency, noisy data examples are provided. The first example is a simple reflection + transmission inverse problem, and the second uses a scaled version of the Marmousi velocity model, dominated by reflections. Both examples are initially started from a semi-infinite half-space with incorrect background velocity. We find that the trans-D tree based approach together with parallel tempering for navigating rugged likelihood (i.e. misfit) topography provides a promising, easily generalized method for solving large-scale geophysical inverse problems which are difficult to optimize, but where the true model contains a hierarchy of features at multiple scales.
International Survey on Technical Aspects of Laparoscopic Liver resection: a web‐based study on the global diffusion of laparoscopic liver surgery prior to the 2nd International Consensus Conference on Laparoscopic Liver Resection in Iwate, Japan

The technique of laparoscopic liver resection (LLR) has been greatly improved since the first international consensus conference. Our aim was to evaluate the worldwide spread of LLR prior to the 2nd International Consensus Conference on Laparoscopic Liver Resection in Iwate, Japan (4–6 October 2014). The International Survey on Technical Aspects of Laparoscopic Liver resection was designed to assess dissemination of LLR, indications, and the surgical techniques. The anonymous questionnaire was e‐mailed to liver surgeons worldwide. A total of 448 liver surgeons responded to the survey. The peak age range of surgeons performing LLR was 41–50 years. Japan had by far the largest number of respondents (n = 223), followed by the US (n = 38) and France (n = 20). In Japan, the majority of surgeons performing LLR belonged to community hospitals, where LLR has been increasingly used since its implementation in 2009 or later, comprising up to 40% of all liver resection cases. In contrast, in North America and Europe, LLR was mostly performed at academic medical centers. LLR has undergone global dissemination after the first international consensus conference in 2008. Japan has experienced unparalleled, explosive diffusion characterized by the adoption of LLR at middle‐tier, regional institutions.
Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy

HIV-infected pregnant women with undetectable plasma HIV RNA concentrations at delivery pose a minimal risk of vertical transmission. We studied the kinetics and the determinants of the virologic response to antiretroviral therapy in 117 consecutive pregnancies. Patients who initiated therapy during pregnancy had a VL decrease of 2 and 2.5 log10 after 4 and 24 weeks, respectively. Therapeutic drug monitoring (TDM) of the protease inhibitors administered in doses recommended for nonpregnant adults resulted in below-target concentrations in 29%, 35%, and 44% of 1st, 2nd, and 3rd trimester measurements, respectively, but low drug concentrations did not correlate with virologic failure. Demographic characteristics, antiretroviral experience prior to pregnancy, baseline VL, or use of specific antiretrovirals did not affect the virologic response. Adherence to ≥95% of prescribed doses and utilization of psychosocial services were associated with undetectable plasma HIV RNA at delivery. In conclusion, the virologic responses of pregnant and nonpregnant adults share similar charactersitics.
Answering Regular Path Queries in Expressive Description Logics: An Automata-Theoretic Approach

Expressive Description Logics (DLs) have been advocated as formalisms for modeling the domain of interest in various application areas. An important requirement is the ability to answer complex queries beyond instance retrieval, taking into account constraints expressed in a knowledge base. We consider this task for positive existential path queries (which generalize conjunctive queries and unions thereof), whose atoms are regular expressions over the roles (and concepts) of a knowledge base in the expressive DL ALCQIbreg. Using techniques based on two-way tree-automata, we first provide an elegant characterization of TBox and ABox reasoning, which gives us also a tight EXPTIME bound. We then prove decidability (more precisely, a 2EXPTIME upper bound) of query answering, thus significantly pushing the decidability frontier, both with respect to the query language and the considered DL. We also show that query answering is Exp-SPACE-hard already in rather restricted settings.
Spatial Perception in Wave Field Synthesis Rendered Sound Fields: Distance of Real and Virtual Nearby Sources

Wave Field Synthesis is capable of reproducing a sound field by means of loudspeaker arrays. It is desired to make a copy of the original sound field in order to create a virtual sound field with the same properties. It has been shown that the properties are similar but not congruent, which leads to the question of what the agreements and differences are with regard to auditory perception. Considerations and experiments are made to illuminate the case of distance perception of virtual sources, and, in particular, the role of the curvature of the wave front for distance perception.
Recovery of Histoplasma capsulatum from BACTEC TB media

From 1990 through 1994, we fortuitously isolated Histoplasma capsulatum from six patients with AIDS whose specimens of blood were processed by the BACTEC system using Middlebrook broth selective for acid-fast bacilli (13A medium). Growth indices became positive after an average of 17 days of incubation (range, 11 to 20 days). No acid-fast bacilli were seen, but small budding yeasts characteristic of H. capsulatum were present.
Near Optimal Multicriteria Spanner Constructions in Wireless Ad-Hoc Networks

In this paper, we study asymmetric power assignments that induce a low-energy k-strongly connected communication graph with spanner properties. We address two spanner models: energy and distance. The former serves as an indicator for the energy consumed in a message propagation between two nodes, while the latter reflects the geographic properties of routing in the induced communication graph. We consider a random wireless ad hoc network with IVI = n nodes distributed uniformly and independently in a unit square. For k ∈ {1, 2}, we propose several power assignments that obtain a good bicriteria approximation on the total cost and stretch factor under the two models. For k > 2, we analyze a power assignment developed by Carmi et al. and derive some interesting bounds on the stretch factor for both models as well. We also describe how to compute all the power assignments distributively, and we provide simulation results. To the best of our knowledge, these are the first provable theoretical bounds for low-cost spanners in wireless ad hoc networks.
Sentence Splitting for Vietnamese-English Machine Translation

Translation quality is often disappointed when a phrase based machine translation system deals with long sentences. Because of syntactic structure discrepancy between two languages, the translation output will not preserve the same word order as the source. When a sentence is long, it should be partitioned into several clauses and the word reordering in the translation should be done within clauses, not between clauses. In this paper, a rule-based technique is proposed to split long Vietnamese sentences based on linguistic information. We use splitting boundaries for translating sentences with two type of constrains: wall and zone. This method is useful for preserving word order and improving translation quality. We describe experiments on translation from Vietnamese to English, showing an improvement BLEU and NIST score.
Design digital mindfulness for personal wellbeing

The digital health and wellbeing movement has led to development of what we here baptize as digital mindfulness applications that allow people to improve psychological wellbeing. The approaches to digital mindfulness vary greatly and as a researcher it can be difficult to gain an overview of the field and what to focus on in one's own research. Here we describe four levels of digital mindfulness with examples and focus on the larger question of how to design for digital mindfulness. We end up with a set of general issues that we hope will generate further discussion and research in the field of digital mindfulness.
Two-level hierarchical register file organization for VLIW processors

High-performance microprocessors are currently designed to exploit the inherent instruction level parallelism (ILP) available in most applications. The techniques used in their design and the aggressive scheduling techniques used to exploit this ILP tend to increase the register requirements of the loops. If more registers than those available in the architecture are required, some actions (such as spill code insertion) have to be applied to reduce this pressure, at the expense of some performance degradation. This degradation could be avoided if a high-capacity register file were included without causing a negative impact on the cycle time of the processor. The authors propose a two-level hierarchical register file organization for VLIW architectures that combines high capacity and low access time. For the configuration proposed in the paper, the new organization achieves a speed-up of 10-14% over a monolithic organization with 64 registers; it is obtained with a 43% (40%) reduction in area (peak power dissipation). Compared to a monolithic file with 32 registers, the speed-up is as much as 38% with just a 14% (4%) increase in area (peak power dissipation).
Childhood tongue squamous cell carcinoma

Background: Tongue squamous cell carcinoma is a very rare disease in children with only a few cases reported in the literature. A case of 15 year old female tongue squamous cell carcinoma (SCC) with review of reported cases is presented. Pediatricians and family physicians should also be aware of the possibility of this disease entity occurring at an earlier age to decrease delay in diagnosis and initiation of treatment.
Differential control of connexin-32 and connexin-43 expression in thyroid epithelial cells: evidence for a direct relationship between connexin-32 expression and histiotypic morphogenesis.

Thyroid epithelial cells cultured either as a monolayer or in the form of follicles, rapidly reconstitute functional gap junctions (Gj). We previously reported that the thyroid Gj gating is regulated by TSH. We have now performed molecular analyses of Gj proteins 1) to detect the connexin(s) (Cx) that is expressed in thyroid epithelial cells, 2) to determine whether the expression of Cx is hormonally regulated, and 3) to analyze the relationship between Cx expression and histiotypic morphogenesis, i.e. folliculogenesis. Studies were carried out on thyrocytes freshly isolated from the gland and on corresponding thyrocytes after 1-7 days in culture as monolayers or in the form of reconstituted follicles. The Cx gene transcription products were analyzed by Northern blot using specific complementary DNA probes for Cx26, Cx32, and Cx43. Cx proteins were identified and estimated by Western blot and indirect immunofluorescence using polyclonal antipeptide antibodies. Cx32 and Cx43 proteins and their corresponding messenger RNA (mRNA) were detected in thyrocytes freshly isolated from the gland. Thyrocytes contained a high amount of the 1.6-kilobase Cx32 mRNA and only traces of the 3-kilobase Cx43 transcript. No Cx26 transcripts could be detected. Thyrocytes cultured at a density of 0.2-0.5 x 10(6) cells/cm2 in the absence of TSH formed monolayers. Surprisingly, monolayer cells lost Cx32 protein within 24 h, and their Cx32 mRNA content decreased from high to barely detectable levels; Cx32 protein was no longer detected throughout the 1-week culture period. On the contrary, Cx43 mRNA and Cx43 protein rapidly increased in monolayer cells to reach very high levels within 2-4 days. Thyrocytes cultured at the same density, but in the presence of TSH also rapidly lost Cx32, but as soon as they reorganized into follicular structures, reexpressed Cx32 at a level (in terms of protein and mRNA) comparable to that found in cells freshly extracted from the gland. As observed for cell monolayers, reconstituted follicles overexpressed Cx43. The Cx43 protein and Cx43 mRNA contents of cultured thyrocytes were 20- to 50-fold higher than those found in isolated thyrocytes at the outset of culture. When thyrocytes were cultured with TSH, but at a low density (< 0.2 x 10(6) cells/cm2) to prevent follicle formation, a TSH-dependent increase in Cx43 was observed in monolayer cells. However, TSH did not cause any reexpression of Cx32. (ABSTRACT TRUNCATED AT 400 WORDS)
The Chlorella variabilis NC64A Genome Reveals Adaptation to Photosymbiosis, Coevolution with Viruses, and Cryptic Sex[C][W]

This report describes the genome sequence of Chlorella variabilis NC64A. Surprisingly, given that NC64A has been thought to be asexual and nonmotile, this work identifies homologs of genes involved in meiosis, gamete fusion, and flagella. Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and a model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing an expansion of protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations in GC content across its genome that correlate with global expression level, average intron size, and codon usage bias. Although Chlorella species have been assumed to be asexual and nonmotile, the NC64A genome encodes all the known meiosis-specific proteins and a subset of proteins found in flagella. We hypothesize that Chlorella might have retained a flagella-derived structure that could be involved in sexual reproduction. Furthermore, a survey of phytohormone pathways in chlorophyte algae identified algal orthologs of Arabidopsis thaliana genes involved in hormone biosynthesis and signaling, suggesting that these functions were established prior to the evolution of land plants. We show that the ability of Chlorella to produce chitinous cell walls likely resulted from the capture of metabolic genes by horizontal gene transfer from algal viruses, prokaryotes, or fungi. Analysis of the NC64A genome substantially advances our understanding of the green lineage evolution, including the genomic interplay with viruses and symbiosis between eukaryotes.
How to Test Cognitive Theory with fMRI

The objective of this chapter is to provide a guide to using functional magnetic resonance imaging (fMRI) to inform cognitive theory. This is, of course, a daunting task, as the premise itself - that fMRI data can inform cognitive theory - is still actively debated. Below, we touch on this debate as a means of framing our guide. In particular, we argue that cognitive theories can be constrained by neuroscientific data, including that offered by fMRI, but to do so requires embellishing the cognitive theory so that it can make predictions for neuroscience; much the same as how testing a cognitive theory using behavior requires embellishing that theory to make experimentally realizable behavioral predictions (i.e., the process of generating operational definitions). Moreover, recent years have seen the development of several new approaches that allow fMRI to better test neurally-embellished models. Along with a review of several ways of testing neurally-embellished cognitive theory using fMRI, we also consider the inferential challenges that can accompany these approaches. Readers of this chapter should gain an understanding of both of the potential power and the challenges associated with fMRI as a cognitive neuroscience methodology.
Comparing regression-adjusted mortality to standardized mortality ratios for trauma center profiling

Background: Trauma center profiling is commonly performed with Standardized Mortality Ratios (SMRs). However, comparison of SMRs across trauma centers with different case mix can induce confounding leading to biased trauma center ranks. We hypothesized that Regression-Adjusted Mortality (RAM) estimates would provide a more valid measure of trauma center performance than SMRs. Objective: Compare trauma center ranks generated by RAM estimates to those generated by SMRs. Materials and Methods: The study was based on data from a provincial Trauma Registry (1999-2006; n = 88,235). SMRs were derived as the ratio of observed to expected deaths using: (1) the study population as an internal standard, (2) the US National Trauma Data Bank as an external standard. The expected death count was calculated as the sum of mortality probabilities for all patients treated in a hospital conditional on the injury severity score, the revised trauma score, and age. RAM estimates were obtained directly from a hierarchical logistic regression model. Results: Crude mortality was 5.4% and varied between 1.3% and 13.5% across the 59 trauma centers. When trauma center ranks from internal SMRs and RAM were compared, 49 out of 59 centers changed rank and six centers changed by more than five ranks. When trauma center ranks from external SMRs and RAM were compared, 55 centers changed rank and 17 changed by more than five ranks. Conclusions: The results of this study suggest that the use of SMRs to rank trauma centers in terms of mortality may be misleading. RAM estimates represent a potentially more valid method of trauma center profiling.
Automated speaker recognition in real world conditions: controlling the uncontrollable

The current development of automatic speaker recognition technology may provide a new method to augment or replace the traditional method offered by qualified experts using aural and spectrographic analysis. The most promising of these automated technologies are based on statistical hypothesis testing methods involving likelihood ratios. The null hypothesis is generated using a universal background model composed of a large population of speakers. However, techniques with excellent performance in standardized evaluations (NIST trials) may not work perfectly in the real world. By defining and controlling the input speech samples carefully, we show quantitative differences in performance for different factors affecting a speaker population, and discuss on-going efforts to improve the accuracy rate for use in real world conditions. In this paper we will address two issues related to the factors that affect the system performance, namely the speech signal duration and the signal-to-noise ratio.