Miracle-dz/UniFAR-FTUs huggingface dataset:
An Efficient Single Image De-Raining Model With Decoupled Deep Networks

Single image de-raining is an emerging paradigm for many outdoor computer vision applications since rain streaks can significantly degrade the visibility and render the function compromised. The introduction of deep learning (DL) has brought about substantial advancement on de-raining methods. However, most existing DL-based methods use single homogeneous network architecture to generate de-rained images in a general image restoration manner, ignoring the discrepancy between rain location detection and rain intensity estimation. We find that this discrepancy would cause feature interference and representation ability degradation problems which significantly affect de-raining performance. In this paper, we propose a novel heterogeneous de-raining architecture aiming to decouple rain location detection and rain intensity estimation (DLINet). For these two subtasks, we provide dedicated network structures according to their differential properties to meet their respective performance requirements. To coordinate the decoupled subnetworks, we develop a high-order collaborative network learning the dynamic inter-layer interactions between rain location and intensity. To effectively supervise the decoupled subnetworks during training, we propose a novel training strategy that imposes task-oriented supervision using the label learned via joint training. Extensive experiments on synthetic datasets and real-world rainy scenes demonstrate that the proposed method has great advantages over existing state-of-the-art methods.
A structural atlas of druggable sites on Nav channels

ABSTRACT Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological significance, dysfunction, or mutations in these channels are associated with various channelopathies. Nav channels are thereby major targets for various clinical and investigational drugs. In addition, a large number of natural toxins, both small molecules and peptides, can bind to Nav channels and modulate their functions. Technological breakthrough in cryo-electron microscopy (cryo-EM) has enabled the determination of high-resolution structures of eukaryotic and eventually human Nav channels, alone or in complex with auxiliary subunits, toxins, and drugs. These studies have not only advanced our comprehension of channel architecture and working mechanisms but also afforded unprecedented clarity to the molecular basis for the binding and mechanism of action (MOA) of prototypical drugs and toxins. In this review, we will provide an overview of the recent advances in structural pharmacology of Nav channels, encompassing the structural map for ligand binding on Nav channels. These findings have established a vital groundwork for future drug development.
Gene silencing of Helicobacter pylori through newly designed siRNA convenes the treatment of gastric cancer

Helicobacter pylori is a gastric pathogen that is responsible for causing chronic inflammation and increasing the risk of gastric cancer development. It is capable of persisting for decades in the harsh gastric environment because of the inability of the host to eradicate the infection. Several treatment strategies have been developed against this bacterium using different antibiotics. But the effectiveness of treating H. pylori has significantly decreased due to widespread antibiotic resistance, including an increased risk of gastric cancer. The small interfering RNAs (siRNA), which is capable of sequence‐specific gene‐silencing can be used as a new therapeutic approach for the treatment of a variety of such malignancies. In the current study, we rationally designed two siRNA molecules to silence the cytotoxin‐associated gene A (CagA) and vacuolating cytotoxin A (VacA) genes of H. pylori for their significant involvement in developing cancer.
A HYBRID APPROACH FOR CLIMATE CHANGE SCENARIO GENERATION FOR BANGLADESH USING GCM MODEL RESULTS

In the 4th assessment report of IPCC, a total of 25 Atmospheric and Ocean Global Circulation Models, AOGCM have been used to project global average surface warming and sea level rise at the end of the year 2100. But the question is whether IPCC derived global and regional (South Asia) scenarios are adequate to represent the climatic condition of Bangladesh. Even in Bangladesh, within 350 km distance, annual precipitation in Sunamganj (Northeast region) is around two and half times than that of the annual precipitation of Chapainababganj (Northwest region) district. So generalizing the distribution of precipitation for overall South Asian region may not represent the climatic situations in Bangladesh. In this paper, a number of GCM models will be selected for generating climatic scenarios for Bangladesh. A sub-set of 8 GCMs was selected based on the models that best simulated the average rainfall during the main monsoon rainy season in Bangladesh (June to August to represent the monsoon), with around 8% increase in the rainfall and 1.6° C increase in the surface temperature.
Network and Computational Drug Repurposing Analysis for c-Myc Inhibition in Burkitt Lymphoma.

BACKGROUND/AIM The treatment rate of Burkitt lymphoma (BL) is still low in low-income countries and among elderly patients. The c-Myc dysregulation induced by mutations is one of the characteristics of BL. However, studies on the downstream signaling pathways of c-Myc are still lacking. This study aimed to identify the signaling pathways regulated by c-Myc. MATERIALS AND METHODS Network and gene set analyses using c-Myc inhibition (i.e., c-Myc knock-down and c-Myc inhibitor treatment) transcriptome datasets for BL cell lines were performed to determine the pathways regulated by c-Myc. In addition, computational drug repurposing was used to identify drugs that can regulate c-Myc downstream signaling pathway. RESULTS Computational drug repurposing revealed that the ERK/MAPK signaling pathway is regulated by c-Myc in BL and that this pathway can be modulated by vorinostat. Furthermore, in the pharmacogenomics database, vorinostat showed a cell viability half-maximal inhibitory concentration of less than 2 μM in the BL cell lines. CONCLUSION The downstream signaling pathway regulated by c-Myc and the drug that can modulate this pathway is presented for the first time.
Assessment of short-term effect of platelet-rich plasma treatment of tendinosis using texture analysis of ultrasound images

Abstract Background Computer-aided diagnosis (i.e., texture analyses) tools are becoming increasingly beneficial methods to monitor subtle tissue changes. The aim of this pilot study was to investigate short-term effect of platelet rich plasma (PRP) treatment in supraspinatus and common extensor of the forearm tendinosis by using texture analysis of ultrasound (US) images as well as by clinical questionnaires. Patients and methods Thirteen patients (7 male and 6 female, age 36–60 years, mean age 51.2 ± 5.2) were followed after US guided PRP treatment for tendinosis of two tendons (9 patients with lateral epicondylitis and 4 with supraspinatus tendinosis). Clinical and US assessment was performed prior to as well as 3 months after PRP treatment with validated clinical questionnaires. Tissue response in tendons was assessed by using gray level run length matrix method (GLRLM) of US images. Results All patients improved of tendinosis symptoms after PRP treatment according to clinical questionnaires. Almost all GLRLM features were statistically improved 3 months after PRP treatment. GLRLM-long run high gray level emphasis (LRLGLE) revealed the best moderate positive and statistically significant correlation after PRP (r = 0.4373, p = 0.0255), followed by GLRLM-low gray level run emphasis (LGLRE) (r = 0.3877, p = 0.05). Conclusions Texture analysis of tendinosis US images was a useful quantitative method for the assessment of tendon remodeling after minimally invasive PRP treatment. GLRLM features have the potential to become useful imaging biomarkers to monitor spatial and time limited tissue response after PRP, however larger studies with similar protocols are needed.
Diverse domain architectures of CheA histidine kinase, a central component of bacterial and archaeal chemosensory systems

Chemosensory systems in bacteria and archaea are complex, multi-protein pathways that enable rapid cellular responses to environmental changes. The CheA histidine kinase is a central component of chemosensory systems. In contrast to other histidine kinases, it lacks a sensor (input) domain and utilizes dedicated chemoreceptors for sensing. CheA is a multi-domain protein; in model organisms as diverse as Escherichia coli and Bacillus subtilis, it contains five single-copy domains. Deviations from this canonical domain architecture have been reported, however, a broad genome-wide analysis of CheA diversity is lacking. Here, we present results of a genomic survey of CheA domain composition carried out using an unbiased set of thousands of CheA sequences from bacteria and archaea. We found that four out of five canonical CheA domains comprise a minimal functional unit (core domains), as they are present in all surveyed CheA homologs. The most common deviations from a classical five-domain CheA architecture are the lack of a P2/CheY-binding domain, which is missing from more than a half of CheA homologs and the acquisition of a response regulator receiver (CheY-like) domain, which is present in ∼35% of CheA homologs. We also document other deviations from classical CheA architecture, including bipartite CheA proteins, domain duplications and fusions, and reveal that phylogenetically defined CheA classes have pre-dominant domain architectures. This study lays a foundation for a better classification of CheA homologs and identifies targets for experimental investigations.
Older age at surgery and postoperative leg length discrepancy are risk factors for unfavourable patient-reported outcome measures of knee tumour endoprostheses following resection for musculoskeletal tumour of the lower limb

Aims To evaluate mid-to long-term patient-reported outcome measures (PROMs) of endoprosthetic reconstruction after resection of malignant tumours arising around the knee, and to investigate the risk factors for unfavourable PROMs. Methods The medical records of 75 patients who underwent surgery between 2000 and 2020 were retrospectively reviewed, and 44 patients who were alive and available for follow-up (at a mean of 9.7 years postoperatively) were included in the study. Leg length discrepancy was measured on whole-leg radiographs, and functional assessment was performed with PROMs (Toronto Extremity Salvage Score (TESS) and Comprehensive Outcome Measure for Musculoskeletal Oncology Lower Extremity (COMMON-LE)) with two different aspects. The thresholds for unfavourable PROMs were determined using anchor questions regarding satisfaction, and the risk factors for unfavourable PROMs were investigated. Results The thresholds for favourable TESS and COMMON were 64.8 and 70.4 points, respectively. Multivariate analysis showed that age at surgery (p = 0.004) and postoperative leg length discrepancy (p = 0.043) were significant risk factors for unfavourable TESS results, while age at surgery (p < 0.001) was a significant risk factor for unfavourable COMMON-LE results. Following receiver operating characteristic analysis, the threshold for both TESS and COMMON-LE was 29 years of age at surgery. Additionally, a leg length discrepancy of 8.2 mm was the threshold for unfavourable TESS. Conclusion Patients aged > 29 years at the time of surgery require appropriate preoperative counselling and adequate postoperative physical and socioemotional support. Reconstruction equivalent to the length of the resected bone can reduce the risk of functional disabilities in daily living. Cite this article: Bone Jt Open 2023;4(12):906–913.
In vivo Optical Coherence Elastography Unveils Spatial Variation of Human Corneal Stiffness.

OBJECTIVE The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the human cornea. METHODS We have developed a high-frequency optical coherence elastography (OCE) technique using shear-like antisymmetric (A0)-mode Lamb waves at frequencies above 10 kHz. RESULTS By incorporating an anisotropic, nonlinear constitutive model and utilizing the acoustoelastic theory, we gained quantitative insights into the influence of corneal tension on wave speeds and elastic moduli. Our study revealed significant spatial variations in the shear modulus of the corneal stroma on healthy subjects for the first time. Over an age span from 21 to 34 (N = 6), the central corneas exhibited a mean shear modulus of 87 kPa, while the corneal periphery showed a significant decrease to 44 kPa. The central cornea's shear modulus decreases with age with a slope of -19 +/- 8 kPa per decade, whereas the periphery showed non-significant age dependence. The limbus demonstrated an increased shear modulus exceeding 100 kPa. We obtained wave displacement profiles that are consistent with highly anisotropic corneal tissues. CONCLUSION Our approach enabled precise measurement of corneal tissue elastic moduli in situ with high precision (< 7%) and high spatial resolution (< 1 mm). Our results revealed significant stiffness variation from the central to peripheral corneas. SIGNIFICANCE The high-frequency OCE technique holds promise for biomechanical evaluation in clinical settings, providing valuable information for refractive surgeries, degenerative disorder diagnoses, and intraocular pressure assessments.
Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non‐alcoholic fatty liver disease

Non‐alcoholic fatty liver disease (NAFLD) is considered as one of the most common diseases of lipid metabolism disorders, which is closely related to bile acids disorders and gut microbiota disorders. Bile acids are synthesized from cholesterol in the liver, and processed by gut microbiota in intestinal tract, and participate in metabolic regulation through the enterohepatic circulation. Bile acids not only promote the consumption and absorption of intestinal fat but also play an important role in biological metabolic signaling network, affecting fat metabolism and glucose metabolism. Studies have demonstrated that exercise plays an important role in regulating the composition and function of bile acid pool in enterohepatic axis, which maintains the homeostasis of the enterohepatic circulation and the health of the host gut microbiota. Exercise has been recommended by several health guidelines as the first‐line intervention for patients with NAFLD. Can exercise alter bile acids through the microbiota in the enterohepatic axis? If so, regulating bile acids through exercise may be a promising treatment strategy for NAFLD. However, the specific mechanisms underlying this potential connection are largely unknown. Therefore, in this review, we tried to review the relationship among NAFLD, physical exercise, bile acids, and gut microbiota through the existing data and literature, highlighting the role of physical exercise in rebalancing bile acid and microbial dysbiosis.
Sr‐Nd isotope composition and clay mineral assemblages in eolian dust from the central Philippine Sea over the last 600 kyr: Implications for the transport mechanism of Asian dust

Dust transport to the tropical/subtropical northwestern Pacific over the past 600 kyr was investigated using radiogenic isotopes (87Sr/86Sr and εNd), together with the clay mineral composition, of eolian dust preserved in a sediment core obtained from the Philippine Sea (12°30′N, 134°60′E). These data revealed the influence of two prevailing dust sources, namely, the Asian deserts and nearby volcanic arcs (e.g., the Luzon Arc), with average contributions of around 70% and 30%, respectively, from each. The clay mineral composition of the core resembled dust from the central Asian deserts (CADs; e.g., the Taklimakan Desert) as in the north‐central Pacific, but published aerosol data collected near the study site during winter/spring have the mineralogical signature of dust originating from the East Asian deserts (EADs). These data indicate that the relative contribution of EAD dust increases with the northeasterly surface winds associated with the East Asian Winter Monsoon (EAWM) during winter/spring, but the Prevailing Westerlies and Trade Winds that carry dust from the CADs is the dominant transport agent in the overall dust budget of the study site. The results of this study contradict the prevailing view that direct dust transport by the EAWM winds in spring dominates the annual flux of eolian dust in the northwest Pacific.
MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice

Abstract Background Depression is a neuropsychiatric disease with a high disability rate and mainly caused by the chronic stress or genetic factors. There is increasing evidence that microRNAs (miRNAs) play a critical role in the pathogenesis of depression. However, the underlying molecular mechanism for the pathophysiology of depression of miRNA remains entirely unclear so far. Methods We first established a chronic social defeat stress (CSDS) mice model of depression, and depression-like behaviors of mice were evaluated by a series of behavioral tests. Next, we detected several abundantly expressive miRNAs suggested in previous reports to be involved in depression and found miR-182-5p was selected as a candidate for analysis in the hippocampus. Then western blotting and immunofluorescence were used together to examine whether adeno-associated virus (AAV)-siR-182-5p treatment alleviated chronic stress–induced decrease in hippocampal Akt/GSK3β/cAMP-response element binding protein (CREB) signaling pathway and increase in neurogenesis impairment and neuroinflammation. Furthermore, CREB inhibitor was adopted to examine if blockade of Akt/GSK3β/CREB signaling pathway abolished the antidepressant actions of AAV-siR-182-5p in mice. Results Knockdown of miR-182-5p alleviated depression-like behaviors and impaired neurogenesis of CSDS-induced mice. Intriguingly, the usage of agomiR-182-5p produced significant increases in immobility times and aggravated neuronal neurogenesis damage of mice. More importantly, it suggested that 666-15 blocked the reversal effects of AAV-siR-182-5p on the CSDS-induced depressive-like behaviors in behavioral testing and neuronal neurogenesis within hippocampus of mice. Conclusions These findings indicated that hippocampal miR-182-5p/Akt/GSK3β/CREB signaling pathway participated in the pathogenesis of depression, and it might give more opportunities for new drug developments based on the miRNA target in the clinic.
Few and far between: clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas

While all peripheral T-cell lymphomas are uncommon, certain subtypes are truly rare, with less than a few hundred cases per year in the USA. There are often no dedicated clinical trials in these rare subtypes, and data are generally limited to case reports and retrospective case series. Therefore, clinical management is often based on this limited literature and extrapolation of data from the more common, nodal T-cell lymphomas in conjunction with personal experience. Nevertheless, thanks to tremendous pre-clinical efforts to understand these rare diseases, an increasing appreciation of the biological changes that underlie these entities is forming. In this review, we attempt to summarize the relevant literature regarding the initial management of certain rare subtypes, specifically subcutaneous panniculitis-like T-cell lymphoma, hepatosplenic T-cell lymphoma, intestinal T-cell lymphomas, and extranodal NK/T-cell lymphoma. While unequivocally established approaches in these diseases do not exist, we make cautious efforts to provide our approaches to clinical management when possible.
Ferromerrillite, Ca9NaFe2+(PO4)7, a new mineral from the Martian meteorites, and some insights into merrillite–tuite transformation in shergottites

Ferromerrillite, ideally Ca 9 NaFe 2+ (PO 4 ) 7 , is a new mineral related to the whitlockite group. It occurs as a common accessory phase in several Martian meteorites classified as basaltic and olivine-phyric shergottites. The mineral described herein originates from the two meteorites Shergotty (the type occurrence) and Los Angeles. Ferromerrillite is trigonal, space group R 3 c ; the unit-cell dimensions (single-crystal data) for material from Shergotty and Los Angeles are, respectively: a 10.372(2) and 10.3794(6); c 37.217(13) and 37.129(2) A; V 3467(3) and 3464.1(1) A 3 ; Z = 6. The calculated density D calc . is 3.11 g/cm 3 based on the empirical formula Ca 9.00 (Na 0.60 Ca 0.07 ) ∑0.67 (Fe 2+ 0.53 Mg 0.40 ) ∑0.93 P 7.08 O 28 (Shergotty) and 3.14 g/cm 3 for Ca 9.00 (Na 0.49 Ca 0.15 ) ∑0.64 (Fe 2+ 0.78 Mg 0.23 ) ∑1.02 P 7.03 O 28 (Los Angeles). The crystal structure of ferromerrillite from the Los Angeles meteorite was solved and refined to R 1 = 0.066 on the basis of 1518 independent reflections with I > 2 σ ( I ). Single-crystal studies reveal that ferromerrilite grains from the two studied shergottites are heavily deformed with an angular mosaicity reaching 7 degrees. The latter imply that the mineral grains experienced a shock event but the impact pressure was not high enough ( 3 (PO 4 ) 2 , to occur. Ferromerrillite is colourless, no cleavage was observed, Mohs’ hardness is ~5. In the immersion liquids, the mineral is colourless and non-pleochroic. It is optically negative, uniaxial to anomalously biaxial with 2 V up to (−)20°. Refractive indices are: ω 1.623(1) and 1.624(1), e 1.621(1) and 1.621(1) for Shergotty and Los Angeles material, respectively. The mineral is named as Fe-dominant analogue of merrillite.
Positive association between adiposity and inflammation in US adults: A cross‐sectional study

Identification of biomarkers involved in multifaceted obesity‐related inflammatory processes paired with reliable anthropometric measures of visceral adiposity is important for developing epidemiologic screening tools. This retrospective observational study used linear regression models to examine the association between inflammation and visceral fat in a nationally representative sample of 10 655 US adults. Inflammation was measured using a cumulative inflammation index (CII) generated from white blood cell ratios and uric acid. Intra‐abdominal adiposity was assessed using sagittal abdominal diameter (SAD). Overall, 67.7%, 18.3%, and 13.9% of adults sampled were normoglycemic, prediabetic, and diabetic, with mean SAD of 21.7 ± 0.11 cm, 24.2 ± 0.14 cm, 26.0 ± 0.18 cm and CII of 4.3 ± 0.05, 4.7 ± 0.09, 5.1 ± 0.09, respectively. For each unit increase in SAD, CII was 0.12 higher (95% CI 0.10, 0.14) in US adults who were normoglycemic, 0.09 higher (95% CI 0.07, 0.12) in prediabetics and 0.10 higher (95% CI 0.07, 0.14) in diabetics. The association between SAD and CII was independent of diabetes status. These findings demonstrate an independent association between adiposity and inflammation, supporting increased visceral fat is associated with increased visceral‐associated inflammation. Future studies are needed to define and characterise obesity‐related inflammatory mediators and their role in chronic disease risk such as diabetes.