Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of human rotavirus subgroups and serotypes in children under five with acute gastroenteritis in a Saudi Hospital

Objectives: Rotavirus is the most common cause of severe diarrhea in children. Currently, there is no published data on the prevalence of subgroups and serotypes of rotavirus in the Eastern province of Saudi Arabia. The objectives of the present study were to assess the rotavirus infection in children with acute gastroenteritis and to assess the subgroups and serotypes of rotavirus in the Children and Maternity Hospital in Dammam, Eastern Saudi Arabia. Materials and Methods: Children under 5 years of age with gastroenteritis attending the emergency rooms, or hospitalized in the pediatric wards of in the Children and Maternity Hospital in Dammam were included in the study (N=156). Laboratory diagnosis of rotavirus shedding was established using the novel rotavirus STAT-PAK immunochromatographical test. Subgroup and G-serotype of the positive stool specimens were analyzed by the ELISA method. Results and Conclusions: Using the novel immmunochromatographic assay, 37 samples were shown to be positive for rotavirus (23.7%). Subgroup I (serotype 2) was found to constitute 5.4% of the isolates and subgroup II (serotypes 1, 3 and 4) was found to constitute 56.7% of the isolates, whereas 37.8% were non-typeable. A survey of serotypes of rotavirus in the whole region as well as in the whole of Saudi Arabia will provide important information about the subgroups and groups of rotavirus in the community and may help in assessing the success of the rotavirus vaccine in the future.
How to Evaluate Health-Related Quality of Life and Its Association with Medication Adherence in Pulmonary Tuberculosis – Designing a Prospective Observational Study in South Africa

Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis (TB) treatment is a public health concern. The main objective of this research is to develop a study design for evaluation of HRQOL and its association with medication adherence in TB in South Africa. Methodology: A conceptual framework for HRQOL in TB has been developed to identify Patient-Reported Outcomes and Quality of Life Database (PROQOLID), (n.d.) measures for HRQOL and adherence and to generate an endpoint model. Two generic (SF-12 and EQ-5D-5L), one disease-specific (St. George’s Respiratory Questionnaire) and one condition-specific (Hospital Anxiety and Depression Scale) measure for HRQOL and Morisky Medication Adherence Scale for adherence assessment were identified. All measures are applied in a longitudinal multi-center study at five data collection time points during standard TB treatment. Statistical analysis includes multivariable analysis. Change over time in the physical component score of SF-12 is defined as primary endpoint. Sample size estimation based thereupon has led to a recruitment target of 96 patients. This study is on-going. Discussion: This is the first longitudinal study in South Africa which evaluates HRQOL and its association with medication adherence in TB in a comprehensive manner. Results will help to improve current treatment programs and medication adherence and will support the identification of sustainable health innovations in TB, determining the value of new products, and supporting decision making with regard to health policy and pricing.
Does a Common Virus Give HIV a Helping Hand?

PARIS-- The discovery that HIV hijacks the cell surface receptors for immune-system signaling molecules, known as chemokines, to force entry into its target cells has revolutionized the field and opened new avenues toward possible therapies. Research reported on page 1874 of this issue of Science suggests that HIV may have yet another port of entry into some cells. The findings implicate a common virus as a possible accomplice of HIV, helping the AIDS virus to infect some types of cells and wreak havoc on the immune system.
Designing Dementia‐Friendly Neighbourhoods: Helping People with Dementia to Get Out and About

This paper summarises research funded by the EPSRC EQUAL programme from 2000 to 2003 to examine how neighbourhoods could be made dementia‐friendly. Design for dementia generally focuses on the internal environment of dementia care homes and facilities, but most people with dementia live at home. Unless they are able to use their local neighbourhoods safely, they are likely to become effectively housebound. There is also increasing awareness of the role the outdoor environment plays in the health, independence, well‐being and cognitive function of people with dementia. The research defined dementia‐friendly neighbourhoods as welcoming, safe, easy and enjoyable for people with dementia and others to access, visit, use and find their around. It identified six design principles: familiarity, legibility, distinctiveness, accessibility, comfort and safety. A number of recommendations for designing and adapting neighbourhoods to be dementia‐friendly arose from the research.
Overexpression of alternatively spliced tissue factor induces the pro-angiogenic properties of murine cardiomyocytic HL-1 cells.

BACKGROUND Tissue factor (TF) is expressed in 2 isoforms: membrane-bound "full length" (fl)TF and soluble alternatively spliced (as)TF. flTF is the major thrombogenic form of TF. Although the function of asTF is poorly understood, it was suggested that asTF contributes to tumor-associated growth and angiogenesis. In the heart of a developing embryo, asTF is expressed much later compared to flTF, but in adult heart, asTF exhibits a distribution pattern similar to that of flTF. Thus, it is possible that asTF may play a role in heart development via pro-angiogenic signaling. The purpose of the present study was to examine the effects of murine asTF overexpression in murine cardiomyocyte-like HL-1 cells on their pro-angiogenic potential, the chemotaxis of monocytic cells, and the expression of fibroblast growth factor-2 (FGF2), cysteine-rich 61 (Cyr61), and vascular endothelial growth factor (VEGF). METHODS AND RESULTS Expression of FGF2, Cyr61 and VEGF was assessed on reverse transcription-polymerase chain reaction and western blot. Cell migration, proliferation, and endothelial tube formation assays were carried out. It was found that overexpression of murine asTF in HL-1 cells increases their proliferation and pro-angiogenic properties. The supernatant of murine asTF-overexpressing HL-1 cells induces the chemotaxis of monocytic cells. CONCLUSIONS Overexpression of murine asTF in murine cardiomyocytic cells increases their proliferation, monocyte migration, and pro-angiogenic properties -possibly- mediated by the induction of the pro-migratory and pro-angiogenic factors FGF2, Cyr61 and VEGF. Thus, we propose that murine asTF may serve as a migration- and angiogenesis-promoting factor.
The Use of Anthropological Field Methods In Education

R apoport and Horvath (1968) refer to Whiteheaďs notion of the hemming in of scientific thought and the threat of impending sterility because the culture "cannot burst through the framework of its own concepts. " They speak of the problem of assuming that a complex phenomenon can be understood by treating it (as the psycho-statistical model does) as if it can be "broken up . into a temporal chain of events, all connected by determinate 'causal' relations. " Such statistical studies of separate variables within the organizational process has, in our view, tested "ungrounded" and often meaningless hypotheses and promises sterility in organization and administrative education theory in the future. The time is long over­ due for another approach in educa­ tion. The anthropological field study approach provides hope for break­ ing through this confining frame­ work of present concepts and open­ ing a new area for educational re­ search. The Field Study Approach
Adaptivity Gaps for Stochastic Probing: Submodular and XOS Functions

Suppose we are given a submodular function f over a set of elements, and we want to maximize its value subject to certain constraints. Good approximation algorithms are known for such problems under both monotone and non-monotone submodular functions. We consider these problems in a stochastic setting, where elements are not all active and we only get value from active elements. Each element e is active independently with some known probability pe, but we don't know the element's status a priori: we find it out only when we probe the element e. Moreover, the sequence of elements we probe must satisfy a given prefix-closed constraint, e.g., matroid, orienteering, deadline, precedence, or any downward-closed constraint. In this paper we study the gap between adaptive and non-adaptive strategies for f being a submodular or a fractionally subadditive (XOS) function. If this gap is small, we can focus on finding good non-adaptive strategies instead, which are easier to find as well as to represent. We show that the adaptivity gap is a constant for monotone and non-monotone submodular functions, and logarithmic for XOS functions of small width. These bounds are nearly tight. Our techniques show new ways of arguing about the optimal adaptive decision tree for stochastic optimization problems.
Discovery of data dependencies in relational databases

Since real world databases are known to be very large, they raise problems of the access. Therefore, real world databases onlycan be accessed by database management systems and the number of accesses has to be reduced to a minimum. Considering this property, we are forced to use standard set–oriented interfaces of relational database management systems. We present a system for discovering data dependencies, which is build upon a set–oriented interface. The point of main effort has been put on the discovery of domain restrictions,unary inclusionand functional dependencies in relational databases. The system also embodies an inference relation to minimize database access.
CRISPR/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs)

Mesenchymal stem cells (MSCs) are multipotent non-hematopoietic progenitor cells that can undergo self-renewal and differentiate into multi-lineages. Bone marrow stromal stem cells (BMSCs) represent one of the most commonly-used MSCs. In order to overcome the technical challenge of maintaining primary BMSCs in long-term culture, here we seek to establish reversibly immortalized mouse BMSCs (imBMSCs). By exploiting CRISPR/Cas9-based homology-directed-repair (HDR) mechanism, we target SV40T to mouse Rosa26 locus and efficiently immortalize mouse BMSCs (i.e., imBMSCs). We also immortalize BMSCs with retroviral vector SSR #41 and establish imBMSC41 as a control line. Both imBMSCs and imBMSC41 exhibit long-term proliferative capability although imBMSC41 cells have a higher proliferation rate. SV40T mRNA expression is 130% higher in imBMSC41 than that in imBMSCs. However, FLP expression leads to 86% reduction of SV40T expression in imBMSCs, compared with 63% in imBMSC41 cells. Quantitative genomic PCR analysis indicates that the average copy number of SV40T and hygromycin is 1.05 for imBMSCs and 2.07 for imBMSC41, respectively. Moreover, FLP expression removes 92% of SV40T in imBMSCs at the genome DNA level, compared with 58% of that in imBMSC41 cells, indicating CRISPR/Cas9 HDR-mediated immortalization of BMSCs can be more effectively reversed than that of retrovirus-mediated random integrations. Nonetheless, both imBMSCs and imBMSC41 lines express MSC markers and are highly responsive to BMP9-induced osteogenic, chondrogenic and adipogenic differentiation in vitro and in vivo. Thus, the engineered imBMSCs can be used as a promising alternative source of primary MSCs for basic and translational research in the fields of MSC biology and regenerative medicine.
Restricted representation of phrase structure grammar for building a tree annotated corpus of Korean

In this paper, we introduce a method to represent phrase structure grammars for building a large annotated corpus of Korean syntactic trees. Korean is different from English in word order and word compositions. As a result of our study, it turned out that the differences are significant enough to induce meaningful changes in the tree annotation scheme for Korean with respect to the schemes for English. A tree annotation scheme defines the grammar formalism to be assumed, categories to be used, and rules to determine correct parses for unsettled issues in parse construction. Korean is partially free in word order and the essential components such as subjects and objects of a sentence can be omitted with greater freedom than in English. We propose a restricted representation of phrase structure grammar to handle the characteristics of Korean more efficiently. The proposed representation is shown by means of an extensive experiment to gain improvements in parsing time as well as grammar size. We also describe the system named Teb that is a software environment set up with a goal to build a tree annotated corpus of Korean containing more than one million units.
Behavioral and Brain Functions

Background: Craving for alcohol is a highly controversial subjective construct and may be clarified by Loewenstein's visceral theory, which emphasizes craving's behavioral effects on the relative value of alcohol. Based on the visceral theory, this study examined the effects of a craving induction on the relative value of alcohol as measured by a behavioral choice task. In addition, based on previous evidence of its role in the expression of craving, the influence of DRD4 VNTR genotype (DRD4-L vs. DRD4-S) was also examined. Methods: Thirty-five heavy drinkers (54% male; 31% DRD4-L) were randomly assigned to receive either a craving induction (exposure to personally relevant alcohol cues) or a control induction (exposure to neutral cues), which was followed by an alcohol-money choice task. Participants were assessed for craving and positive/negative affect throughout the procedure, and relative value of alcohol was derived from participant choices for alcohol versus money. DRD4 VNTR status was assessed retrospectively via buccal samples using previously established protocols. Results: Factorial analysis of the craving induction revealed that it was associated with significant increase in craving (p < .001), but not greater relative value of alcohol. Factorial analyses including DRD4 VNTR genotype of did not suggest an influence on reactivity to the craving induction, although this analysis was substantially compromised by small cell sample sizes. Continuous analyses revealed that craving was significantly associated with the relative value of alcohol (p < .05) and possession of the DRD4-L allele further amplified this relationship (p < .001). Conclusion: These results are interpreted as generally supporting Loewenstein's visceral theory of craving and evidence of a functional role of DRD4 VNTR genotype in the expression of craving for alcohol. Methodological limitations, mechanisms underlying these findings, and future directions are discussed. Published: 19 February 2007 Behavioral and Brain Functions 2007, 3:11 doi:10.1186/1744-9081-3-11 Received: 1 December 2006 Accepted: 19 February 2007 This article is available from: http://www.behavioralandbrainfunctions. com/content/3/1/11 © 2007 MacKillop et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Incremental Generation of Spatial Referring Expressions in Situated Dialog

This paper presents an approach to incrementally generating locative expressions. It addresses the issue of combinatorial explosion inherent in the construction of relational context models by: (a) contextually defining the set of objects in the context that may function as a landmark, and (b) sequencing the order in which spatial relations are considered using a cognitively motivated hierarchy of relations, and visual and discourse salience.
Low‐Income Women Speak out About Housing: A High‐Stakes Game of Musical Chairs

This review of the social science literature examines correlates of homelessness. The review is supplemented by the voices of 12 low-income women who are temporarily housed or living in public housing. Homelessness for women is associated with teen pregnancy and parenting, domestic violence, working at minimum-wage jobs, and waiting lists of several years for subsidized housing. We conclude with a summary of women’s experiences accessing government housing programs. Public policy recommendations regarding housing programs are made. Government housing programs are briefly described in an Appendix to the article.
Internet use, misuse, and addiction in adolescents: current issues and challenges

Abstract The Internet has revolutionized education and social communication in the 21st century. This article reviews the growing literature identifying a number of adolescents and young adults with a pathologically excessive Internet use leading to many potential consequences. Current research dilemmas in this area include that Internet addiction is a broad topic with no standard definition and no standard measurement tools. Management of youth with identified problematic Internet use or misuse centers on behavioral therapy and treatment of comorbidities. Pharmacologic approaches are limited at this time but are undergoing research, such as use of opioid antagonists and antidepressants in adults with pathological gambling. Efforts should be expanded on not only the education of all adolescents regarding the benefits but also the potential negative consequences of Internet use. It is vital that we do this for Generation Z, whereas Generation ALPHA will soon benefit or suffer from our efforts in this regard today.
From Parity to Preference-based Notions of Fairness in Classification

The adoption of automated, data-driven decision making in an ever expanding range of applications has raised concerns about its potential unfairness towards certain social groups. In this context, a number of recent studies have focused on defining, detecting, and removing unfairness from data-driven decision systems. However, the existing notions of fairness, based on parity (equality) in treatment or outcomes for different social groups, tend to be quite stringent, limiting the overall decision making accuracy. In this paper, we draw inspiration from the fair-division and envy-freeness literature in economics and game theory and propose preference-based notions of fairness -- given the choice between various sets of decision treatments or outcomes, any group of users would collectively prefer its treatment or outcomes, regardless of the (dis)parity as compared to the other groups. Then, we introduce tractable proxies to design margin-based classifiers that satisfy these preference-based notions of fairness. Finally, we experiment with a variety of synthetic and real-world datasets and show that preference-based fairness allows for greater decision accuracy than parity-based fairness.
A population-based assessment of the impact and burden of caregiving for long-term stroke survivors.

BACKGROUND AND PURPOSE Little attention has been focused on the demands on caregivers in stroke outcome research. A major aim of this study was to identify factors in patients associated with emotional distress in caregivers 1 year after stroke. METHODS One-year stroke survivors with residual handicap (defined by the Oxford Handicap Scale) and their chief caregivers were interviewed as part of the follow-up activities for patients (n = 492) registered with the Perth Community Stroke Study. We assessed emotional distress in caregivers using the Hospital Anxiety and Depression Scale and the 28-item General Health Questionnaire. Appropriate sections of the Social Behaviour Assessment Schedule were used to assess the patient's behavior and the impact on the caregiver's life. Other aspects of the patient's functional state were assessed with the Barthel Index, the Mini-Mental State Examination, the Frenchay Activities Index, and the Psychiatric Assessment Schedule (at 4 months after stroke). RESULTS Of 241 patients who survived to 1 year after stroke and were living outside of an institution, 103 patients (43%; 95% confidence interval, 37% to 49%) were handicapped. Eighty-four patient/caregiver units were assessed from this latter group. Almost all caregivers reported adverse effects on their emotional health, social activities, and leisure time, and more than half reported adverse effects on family relationships. Forty-six caregivers (55%) showed evidence of emotional distress on either of the two screening instruments, particularly if they were caregiving for patients with dementia and/or abnormal behavior. There was no significant relationship between emotional illness among caregivers and the degree of patients' physical disability. CONCLUSIONS In this population, the high level of emotional distress among caregivers of stroke patients suggests that many caregivers have unmet needs. Community services need to focus attention on the neuropsychological aspects of stroke patients and the social functioning of caregivers who support them.
Information vs. Robustness in Rank Aggregation: Models, Algorithms and a Statistical Framework for Evaluation

The rank aggregation problem has been studied extensively in recent years with a focus on how to combine several dierent rankers to obtain a consensus aggregate ranker. We study the rank aggregation problem from a dierent perspective: how the individual input rankers impact the performance of the aggregate ranker. We develop a general statistical framework based on a model of how the individual rankers depend on the ground truth ranker. Within this framework, one can generate synthetic data sets and study the performance of dierent aggregation methods. The individual rankers, which are the inputs to the rank aggregation algorithm, are statistical perturbations of the ground truth ranker. With rigorous experimental evaluation, we study how noise level and the misinformation of the rankers aect the performance of the aggregate ranker. We introduce and study a novel
Acute Impact of Severe Traumatic Brain Injury on Family Structure and Coping Responses

Family stress following traumatic brain injury (TBI) is well documented. Previous studies have shown that family adaptation and the use of coping strategies moderate the stresses of TBI in the long term. However, relatively little is known about the impact on the family and family response during the acute stage of recovery. The present study used Olson's Circumplex Model to examine acute changes in family structure and examined changes in coping responses pre- and post-TBI. Wives of 20 male TBI survivors completed the Couples Version of the Family Adaptability and Cohesion Evaluation Scales-II (FACES-II) and the Coping Responses Inventory (CRI). These questionnaires were completed retrospectively for a stressful event that occurred six months prior to the TBI, then for the current period following the TBI. Results found that 60% of all families experienced a significant change in structure following TBI. As predicted by the Circumplex Model, balanced families changed most, with 70% changing to the extreme type post-TBI. Focus of coping (problem versus emotion) and coping techniques (cognitive versus behavioral) also changed significantly from pre- to post-TBI and differed, depending on post-TBI family structure. Family interventions based on these differences in family structure and coping are presented.