Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing heterogeneous student bodies using a methodology that encourages the acquisition of skills valued by employers

This work compares the results of three assessment systems used in two Spanish universities (the Universidad Politécnica de Madrid and the Universidad Católica de Ávila): the traditional system based on final examinations, continuous assessment with periodic tests and a proposed system (specially designed for heterogeneous student bodies) orientated towards motivating students. This third system involved dividing the syllabus into two different parts: a common core assessed by multiple choice tests, and a specialisation assessed by a literature review, the writing of an article and an oral presentation. The latter skills are highly valued by employers. The proposed system led to a greater pass rate than that achieved by students taking similar courses assessed by the more conventional systems. In addition, the results show that involving students in the assessment process increases their participation in their studies and generates a feeling of satisfaction and justice.
Second Language (L2) English and Third Language (L3) French Article Acquisition by Native Speakers of Cantonese

This paper looks at the acquisition of articles and related nominal functional properties (the status of classifier, the singular–plural distinction) in English and French by native speakers of Hong Kong Cantonese. Two experimental studies are reported. In the generative SLA literature, there is disagreement as to which properties of the grammar will transfer from the first language (L1) at early stages of L2 acquisition and what the path of subsequent development might look like. We present L1 Cantonese–L2 English as well as L1 Cantonese–L2 English–L3 French data collected from learners of different proficiency levels on a variety of experimental tasks to shed light on these debates. Our findings largely support Full Transfer Full Access, a position that posits strong transfer and no impairment in SLA.
How to study deep roots—and why it matters

The drivers underlying the development of deep root systems, whether genetic or environmental, are poorly understood but evidence has accumulated that deep rooting could be a more widespread and important trait among plants than commonly anticipated from their share of root biomass. Even though a distinct classification of “deep roots” is missing to date, deep roots provide important functions for individual plants such as nutrient and water uptake but can also shape plant communities by hydraulic lift (HL). Subterranean fauna and microbial communities are highly influenced by resources provided in the deep rhizosphere and deep roots can influence soil pedogenesis and carbon storage.Despite recent technological advances, the study of deep roots and their rhizosphere remains inherently time-consuming, technically demanding and costly, which explains why deep roots have yet to be given the attention they deserve. While state-of-the-art technologies are promising for laboratory studies involving relatively small soil volumes, they remain of limited use for the in situ observation of deep roots. Thus, basic techniques such as destructive sampling or observations at transparent interfaces with the soil (e.g., root windows) which have been known and used for decades to observe roots near the soil surface, must be adapted to the specific requirements of deep root observation. In this review, we successively address major physical, biogeochemical and ecological functions of deep roots to emphasize the significance of deep roots and to illustrate the yet limited knowledge. In the second part we describe the main methodological options to observe and measure deep roots, providing researchers interested in the field of deep root/rhizosphere studies with a comprehensive overview. Addressed methodologies are: excavations, trenches and soil coring approaches, minirhizotrons (MR), access shafts, caves and mines, and indirect approaches such as tracer-based techniques.
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical–gene–disease networks

The Comparative Toxicogenomics Database (CTD) is a curated database that promotes understanding about the effects of environmental chemicals on human health. Biocurators at CTD manually curate chemical–gene interactions, chemical–disease relationships and gene–disease relationships from the literature. This strategy allows data to be integrated to construct chemical–gene–disease networks. CTD is unique in numerous respects: curation focuses on environmental chemicals; interactions are manually curated; interactions are constructed using controlled vocabularies and hierarchies; additional gene attributes (such as Gene Ontology, taxonomy and KEGG pathways) are integrated; data can be viewed from the perspective of a chemical, gene or disease; results and batch queries can be downloaded and saved; and most importantly, CTD acts as both a knowledgebase (by reporting data) and a discovery tool (by generating novel inferences). Over 116 000 interactions between 3900 chemicals and 13 300 genes have been curated from 270 species, and 5900 gene–disease and 2500 chemical–disease direct relationships have been captured. By integrating these data, 350 000 gene–disease relationships and 77 000 chemical–disease relationships can be inferred. This wealth of chemical–gene–disease information yields testable hypotheses for understanding the effects of environmental chemicals on human health. CTD is freely available at http://ctd.mdibl. org.
Outlines of a theory of visual pattern recognition in animals and man

This paper lists twelve conditions that must be fulfilled by a satisfactory theory of visual pattern recognition in animals and man : such a theory must explain (1) size invariance, (2) position invariance, (3) brightness invariance, (4) the equivalence of outline and filled-in shapes, (5) lack of invariance under most rotations, (6) the known confusions made between patterns, (7) animals’ ability to disregard jitter, (8) the human ability to segment shapes in different ways, (9) the way in which man recognizes complex scenes without recognizing individual details of the scene, (10) perceptual learning, (11) the way in which the brain takes advantage of the redundancy of the visual environment; (12) finally any theory must be consistent with the physiological evidence. The outlines of a theory meeting these conditions are put forward. The model has three parts : (1) A processor that extracts local features from the input picture preserving information about the spatial relationships between the features. (2) A mechanism that induces an abstract description of the output from the processor. (3) A store in which such descriptions are held. Some suggestions are made about the language in which descriptions are framed : it must contain hierarchical elements to allow for the possibility of segmenting a picture in different ways. It is shown how the properties of such a language could account for the facts listed above. In recognizing a picture the output from the store is matched to a stored descriptive rule. What we see is the descriptive rule selected to describe an input picture—we cannot respond to details of the picture not represented in the rule. Since, however, many different rules describe the same input picture, animals and man respond to different aspects of the same picture on different occasions of presentation.
Effects of Chronic Baroreceptor Stimulation on the Autonomic Cardiovascular Regulation in Patients With Drug-Resistant Arterial Hypertension

In patients with drug-resistant hypertension, chronic electric stimulation of the carotid baroreflex is an investigational therapy for blood pressure reduction. We hypothesized that changes in cardiac autonomic regulation can be demonstrated in response to chronic baroreceptor stimulation, and we analyzed the correlation with blood pressure changes. Twenty-one patients with drug-resistant hypertension were prospectively included in a substudy of the Device Based Therapy in Hypertension Trial. Heart rate variability and heart rate turbulence were analyzed using 24-hour ECG. Recordings were obtained 1 month after device implantation with the stimulator off and after 3 months of chronic electric stimulation (stimulator on). Chronic baroreceptor stimulation decreased office blood pressure from 185±31/109±24 mm Hg to 154±23/95±16 mm Hg (P<0.0001/P=0.002). Mean heart rate decreased from 81±11 to 76±10 beats per minute−1 (P=0.001). Heart rate variability frequency-domain parameters assessed using fast Fourier transformation (FFT; ratio of low frequency:high frequency: 2.78 versus 2.24 for off versus on; P<0.001) were significantly changed during stimulation of the carotid baroreceptor, and heart rate turbulence onset was significantly decreased (turbulence onset: −0.002 versus −0.015 for off versus on; P=0.004). In conclusion, chronic baroreceptor stimulation causes sustained changes in heart rate variability and heart rate turbulence that are consistent with inhibition of sympathetic activity and increase of parasympathetic activity in patients with drug-resistant systemic hypertension; these changes correlate with blood pressure reduction. Whether the autonomic modulation has favorable cardiovascular effects beyond blood pressure control should be investigated in further studies.
Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma

The invasion process is a crucial step for pancreatic ductal adenocarcinoma (PDAC); however, the genes related to invasion remain unclear. To identify specific genes for the invasion process, we compared microarray data for infiltrating cancer and PanIN‐3, which were harvested from an individual PDAC patient by microdissection. Furthermore, immunohistochemical, coimmunoprecipitation and invasion analyses were performed to confirm the biologic significance of molecules identified by expression profile. In the present study, we focused on MUC16 and mesothelin among 87 genes that were significantly upregulated in infiltrating components compared to PanIN‐3 in all PDAC patients, because MUC16 was the most differently expressed between two regions, and mesothelin was reported as the receptor for MUC16. Immunohistochemical analysis revealed that MUC16 and mesothelin were expressed simultaneously only in infiltrating components and increased at the invasion front, and binding of MUC16 and mesothelin was found in PDAC by immunoprecipitation assay. The downregulation of MUC16 by shRNA and the blockage of MUC16 binding to mesothelin by antibody inhibited both invasion and migration of pancreatic cancer cell line. MUC16 high/mesothelin high expression was an independent prognostic factor for poor survival in PDAC patients. In conclusion, we identified two specific genes, MUC16 and mesothelin, associated with the invasion process in patients with PDAC. (Cancer Sci 2012; 103: 739–746)
Power and Thermal Modeling for Communication Systems

Power and thermal characteristics have emerged as first-order design goals for all types of semiconductors, including embedded signal and information processing systems. This paper surveys the basic physical principles of power and thermal behavior and argues that statistical models, such as Markov decision processes, are well-suited to the management of power and thermal behavior at both design time and run time.
A Disability Studies Perspective on the Bush Education Agenda: The No Child Left Behind Act of 2001 1

Our educational system is undergoing great scrutiny. The success of our nation's schools and their students is under serious evaluation and interpretation. Currently, one of the most visible and pertinent “political products” impacting our schools and students is the federal legislation No Child Left Behind (2002). Specific concerns arise around schools' ability to include students with disabilities, among other “disadvantaged groups,” in strategies for academic success. Disability Studies contends that the place and positioning of disability is fundamentally political. This article uses a Disability Studies lens to critique NCLB. The potential benefits, problematic areas, and dangerous aspects to schools, teachers, parents, students with disabilities, and the community at large are presented within this Disability Studies context.
Challenges for Deploying Web Services-Based E-Business Systems in SMEs

E-business initiative in many companies had started in the 1990s. These companies have recently begun to explore the use of Web Services (WS) technologies within their e-business context, since they provide an attractive, language-neutral, environment-neutral programming model that accelerates application development and integration inside and outside the enterprise. Despite these advantages, companies are slow to deploy WS because it requires a considerable shift in their application development process. While a few studies have reported on some of the reasons for this wait-and-see approach, a thorough and systematic investigation of the challenges from the stakeholdersâ€™ â€” providers, consumers, and standards organizations â€” perspective is needed. This study addresses that and provides a framework for studying the factors that impact the deployment and use of WS. The framework is used to analyze small and medium-sized enterprises (SMEs), as they play a vital role in generating employment opportunity and turnover within many major economies globally.
Molecular Mechanisms of Natural Killer Cell Activation

With an array of activating and inhibitory receptors, natural killer (NK) cells can specifically eradicate infected and transformed cells. Target cell killing is achieved through directed release of lytic granules. Recognition of target cells also induces production of chemokines and cytokines that can coordinate immune responses. Upon contact with susceptible cells, a multiplicity of activating receptors can induce signals for adhesion. Engagement of the integrin leukocyte functional antigen-1 mediates firm adhesion, provides signals for granule polarization and orchestrates the structure of an immunological synapse that facilitates efficient target cell killing. Other activating receptors apart from leukocyte functional antigen-1 signal for lytic granule exocytosis, a process that requires overcoming a threshold for activation of phospholipase C-γ, which in turn induces STIM1- and ORAI1-dependent store-operated Ca2+ entry as well as exocytosis mediated by the SNARE-containing protein syntaxin-11 and regulators thereof. Cytokine and chemokine release follows a different secretory pathway which also requires phospholipase C-γ activation and store-operated Ca2+ entry. Recent studies of human NK cells have provided insights into a hierarchy of effector functions that result in graded responses by NK cell populations. Responses display cellular heterogeneity and are influenced by environmental cues. This review highlights recent knowledge gained on the molecular pathways for and regulation of NK cell activation.
The current practices of intervention with batterers

Background Since the 70s there was a proliferation of intervention programs for batterers; however the results remain controversial. Objectives This study aims to analyse the literature published between the years of 2000 and 2013 about the effectiveness of the intervention with batterers. Methods A review of papers about intervention with batterers published during this period (2000-2013) was conducted. Social sciences databases were checked. Papers about programs for a specific public or programs with a broad intervention focus, and with female and homosexual offenders were excluded. Results Thirty-six studies that described 37 intervention programs fulfilled the inclusion criteria. In general, the analysed programs adopted a group format (70.3%) and a cognitive-behavioural (56.8%) or psychoeducational (18.9%) intervention model (32.4% assumed to adopt a Duluth model). Concerning the effectiveness, results showed success rates of 39.4%-97%, dropout rates of 10%-58% and recidivism rates of 0%-65.9%. Discussion The effectiveness of intervention with batterers remains controversial, which seems to be due to the different methodologies used in the studies. Despite the inconsistencies, programs for perpetrators are an important way to reduce intimate partner violence recidivism.
A near-global, 2-hourly data set of atmospheric precipitable water from ground-based GPS measurements

[1] A 2-hourly data set of atmospheric precipitable water (PW) has been produced from the zenith path delay (ZPD) derived from ground-based Global Positioning System (GPS) measurements. The PW data are available every 2 hours from 80 to 268 International GNSS Service (IGS, formally International GPS Service) ground stations from 1997 to 2004. The accuracy of the IGS ZPD product is roughly 4 mm. An analysis technique is developed to convert ZPD to PW on a global scale. Special efforts are made on deriving surface pressure (Ps) and water-vapor-weighted atmospheric mean temperature (Tm), which are two key parameters for converting ZPD to PW. Ps is derived from global, 3-hourly surface synoptic observations with temporal, vertical and horizontal adjustments. Tm is calculated from NCEP/NCAR reanalysis with temporal, vertical and horizontal interpolations. The derived Ps and Tm at the GPS location and height have root-mean-square (rms) errors of 1.65 hPa and 1.3 K, respectively. A theoretical error analysis concludes that typical PW error associated with the errors in ZPD, Tm and Ps is on the order of 1.5 mm. The PW data set is compared with radiosonde, microwave radiometer (MWR) and satellite data. The GPS and radiosonde PW comparisons at 98 stations around the globe show a mean difference of 1.08 mm (drier for radiosonde data) with a standard deviation of differences of 2.68 mm, which corresponds to mean percentage difference and standard deviation of 5.5% and 10.6%, respectively. The bias is primarily due to known dry biases in the Vaisala radiosonde data. The RMS difference between GPS and radiosonde/MWR data ranges from 1.2 mm to 2.83 mm. The latitudinal and seasonal variations of PW derived from the GPS data agree well with that from International Satellite Cloud Climatology Project (ISCCP) data if the ISCCP data are sampled only at grid boxes containing GPS stations. The large difference between GPS and ISCCP data in the subtropics is interesting, but is not easily explained. The comparisons did not reveal any systematic bias in GPS PW data and show that a RMS difference of less than 3 mm between GPS-derived PW and other data sets is achieved. The comparison study also illustrates the value of GPS-estimated PW for examining the quality of other data sets, such as those from radiosondes and MWR. Preliminary analysis of this data set shows interesting and significant diurnal variations in PW in four different regions.
A New Stictoponera, With Notes on the Genus (Hymenoptera: Formicidæ)

Among ants collected in Western China during the years 1944 and 1945, I have two specimens of a new Stictoponera collected on high, sharp ridge near Chao Kung Mountain and about one and one-half days’ travel afoot west of Kuanhsien, Szechuan Province, China. The elevation was between 5000 and 7500 feet, probably closer to the higher altitude, in the zone of dense bamboo growth. The ants were taken together in the thin bamboo humus at the ridge summit. They moved very slowly, and resembled our species of Proceratium in their sluggish locomotion and in feigning death at the approach of danger.
The RE1 Binding Protein REST Regulates Oligodendrocyte Differentiation

The RE1-silencing transcription factor (REST) represses the expression of neuronal-specific genes in non-neuronal cells by recruiting histone deacetylases (HDACs) and other histone modifying and chromatin remodeling proteins to the DNA. REST regulation of the expression of neuronal genes is required for the orderly developmental transition from a neuroepithelial stem cell to a functional neuron. Here, we examined the expression and function of REST in neonatal rat oligodendrocyte precursor cells (OPCs). OPCs develop from the same neuroepithelial stem cells as neurons, can be reprogrammed to act as neural stem-like cells in vitro, and require HDAC-mediated gene repression to develop into mature oligodendrocytes. We show that OPCs express functional REST protein and that REST interacts with several neuronal-specific genes whose expression is repressed in OPCs. REST transcript and protein expression increased fourfold during the first 48 h of oligodendrocyte differentiation. During this differentiation, the expression of RE1 containing neuronal genes further decreased as the transcription of oligodendrocyte-specific genes was activated. Expression of a dominant-negative form of REST in OPCs prevented the cells from developing into mature MBP-positive oligodendrocytes. Rather, the cells began to develop a neuronal phenotype characterized by increased expression of neuronal proteins, transcription factors, and cell-type-specific marker antigens. REST overexpression promoted the development of O4-positive pre-oligodendrocytes from OPCs. Together, these results show that REST function is required for the differentiation of OPCs into oligodendrocytes. By regulating the expression of neuronal genes, REST may also regulate the phenotypic plasticity of OPCs.
Augmenting spatial awareness with Haptic Radar

We are developing a modular electronic device to allow users to perceive and respond simultaneously to multiple spatial information sources using haptic stimulus. Each module of this wearable "haptic radar" acts as an artificial hair capable of sensing obstacles, measuring their range and transducing this information as a vibro-tactile cue on the skin directly beneath the module. Our first prototype (a headband) provides the wearer with 360 degrees of spatial awareness thanks to invisible, insect-like antennas. During a proof-of-principle experiment, a significant proportion (87%, p = 1.26 * 10-5) of participants moved to avoid an unseen object approaching from behind without any previous training. Participants reported the system as more of a help, easy, and intuitive. Among the numerous potential applications of this interface are electronic travel aids and visual prosthetics for the blind, augmentation of spatial awareness in hazardous working environments, as well as enhanced obstacle awareness for motorcycle or car drivers (in this case the sensors may cover the surface of the car).
New On-Line Algorithms for the Page Replication Problem

We present improved competitive on-line algorithms for the page replication problem and concentrate on important network topologies for which algorithms with a constant competitive factor can be given. We develop an optimal randomized on-line replication algorithm for trees and uniform networks; its competitive factor is approximately 1.58. Furthermore we consider on-line replication algorithms for rings and present general techniques that transform large classes of c-competitive algorithms for trees into 2c-competitive algorithms for rings. As a result we obtain a randomized on-line algorithm for rings that is 3.16-competitive. We also derive two 4-competitive on-line algorithms for rings which are either deterministic or memoryless.