Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype*

Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli. Senescent cells often express p16INK4a, a cyclin-dependent kinase inhibitor, tumor suppressor, and biomarker of aging, which renders the senescence growth arrest irreversible. Senescent cells also acquire a complex phenotype that includes the secretion of many cytokines, growth factors, and proteases, termed a senescence-associated secretory phenotype (SASP). The SASP is proposed to underlie age-related pathologies, including, ironically, late life cancer. Here, we show that ectopic expression of p16INK4a and another cyclin-dependent kinase inhibitor, p21CIP1/WAF1, induces senescence without a SASP, even though they induced other features of senescence, including a stable growth arrest. Additionally, human fibroblasts induced to senesce by ionizing radiation or oncogenic RAS developed a SASP regardless of whether they expressed p16INK4a. Cells induced to senesce by ectopic p16INK4a expression lacked paracrine activity on epithelial cells, consistent with the absence of a functional SASP. Nonetheless, expression of p16INK4a by cells undergoing replicative senescence limited the accumulation of DNA damage and premature cytokine secretion, suggesting an indirect role for p16INK4a in suppressing the SASP. These findings suggest that p16INK4a-positive cells may not always harbor a SASP in vivo and, furthermore, that the SASP is not a consequence of p16INK4a activation or senescence per se, but rather is a damage response that is separable from the growth arrest.
Perception in graphics, visualization, virtual environments and animation

The advent of affordable display technology and seamless integration of real-world scenes with computer graphics fuels our continuing ability to create and display stunning realistic imagery. With the arrival of new technology, algorithms and display methods comes the realization that gains can be made by tailoring output to the intended audience - humans. Human beings have amazingly complex perceptual systems, which have the ability to quickly capture and process vast amounts of complex data. With all its capability however, the Human Visual System (HVS) has some surprising nuances and limitations that can be exploited to the benefit of numerous graphics applications. This short course will provide insight into those aspects of HVS and other perceptual systems that can serve as both a guide and yard-stick to further the development and evaluation of computer graphics imagery and presentations. The literature on perception provides a rich source of knowledge that can be applied to the realm of computer graphics for immediate and direct benefit, generating images that not only exhibit higher quality, but use less time and resources to process. In addition, knowledge of the HVS serves as a guide on how best to present the images to fulfill the application at hand.
A Single-Blinded, Direct Observational Study of PGY-1 Interns and PGY-2 Residents in Evaluating their History-Taking and Physical-Examination Skills.

BACKGROUND Internal Medicine residents and interns are often the first contact for newly admitted patients in a teaching hospital. The proper evaluation, diagnosis, and treatment may depend on this initial encounter. OBJECTIVES To evaluate the history-taking and physical-examination skills of interns/residents on new admissions to the medical floors; to compare data from the patient encounter to the chart for evidence of accuracy; to measure the time spent on the initial encounter. METHODS An independent medical observer used a yes/no checklist with 60 variables in a single-blinded observational study. Frequency tables were generated and results were based on descriptive statistics. RESULTS In 7 categories specifically aimed at chart review for accuracy, discrepancies were found between what medical post-graduate year (PGY)-1 interns and PGY-2 residents (interns/residents) recorded in the patient's chart and the observed actions during the patient encounter. There were 25 encounters observed. In 64%, the time spent on history taking was <7 minutes. In 68%, the time spent for the physical examination was <5 minutes. In 72%, patients were notasked about family medical history. None ofthe observed interns/residents took their own measurements of the patient's blood pressure. No intern/resident asked about recent weight loss, weight gain, level of salt intake, despite patients with history of hypertension; nor did they perform any examinations of the eye fundi and accommodation, thyroid, carotids, or hearing. The majority of patients were asked about chest pain, cough, nausea, vomiting, chief complaint, and the onset of symptoms. CONCLUSIONS This study documents the poor overall performance in the quality of history-taking and physical-examination skills on newly admitted patients.
Evolutionary psychology and information systems research : a new approach to studying the effects of modern technologies on human behavior

Theoretical and Conceptual Issues. - Evolutionary Psychology and Information Systems Theorizing. - Group-Level Evolution and Information Systems: What Can We Learn From Animal Colonies in Nature? - Applying Evolutionary Psychology to the Study of Post-adoption Information Technology Use: Reinforcement, Extension, or Revolution? - The Behavioral Ecology of Human Foraging in an Online Environment: Of Omnivores, Informavores, and Hunter-Gatherers. - Empirical Research Exemplars. - Surprise and Human Evolution: How a Snake Screen Enhanced Knowledge Transfer Through a Web Interface. - How Do e-Learners Participate in Synchronous Online Discussions? Evolutionary and Social Psychological Perspectives. - Who Is in Your Shopping Cart? Expected and Experienced Effects of Choice Abundance in the Online Dating Context. - Cognitive Adaptation and Collective Action: The P2P File-Sharing Phenomenon. - Studying Invisibly: Media Naturalness and Learning. - Using Evolutionary Psychology to Extend Our Understanding of Fit and Human Drives in Information Systems (IS) Utilization Decisions and Performance. - The Interaction of Communication Medium and Management Control Systems in the Processes and Outcomes of Transfer Price Negotiations. - A Research Model for Online Social Behavior Based on an Evolutionary, Social Psychological, and Technological Approach. - Emerging Issues and Debate. - Costly Traits and e-Collaboration: The Importance of Oral Speech in Electronic Knowledge Communication. - Homo Virtualensis: Evolutionary Psychology as a Tool for Studying Video Games. - The Modern Hunter-Gatherer Hunts Aliens and Gathers Power-Ups: The Evolutionary Appeal of Violent Video Games and How They Can Be Beneficial. - Three Roads to Cultural Recurrence. - Evolution as Metaphor: A Critical Review of the Use of Evolutionary Concepts in Information Systems and e-Commerce.
The Thurston's program derived from the Langlands global program with singularities

The seven non euclidean geometries of the Thurston's geometrization program are proved to originate naturally from singularization morphisms and versal deformations on euclidean 3-manifolds generated in the frame of the Langlands global program. The Poincare conjecture for a 3-manifold appears as a particular case of this new approach of the Thurston'program.
Consciousness and the Social Brain

Part I: The Theory Chapter 1: The magic trick Chapter 2: Introducing the theory Chapter 3: Awareness as information Chapter 4: Being aware versus knowing that you are aware Chapter 5: The attention schema Chapter 6: Illusions and myths Chapter 7: Social attention Chapter 8: How do I distinguish my awareness from yours? Chapter 9: Some useful complexities Part II: Comparison to previous theories and results Chapter 10: Social theories of consciousness Chapter 11: Consciousness as integrated information Chapter 12: Neural correlates of consciousness Chapter 13: Awareness and the machinery for social perception Chapter 14: The neglect syndrome Chapter 15: Multiple interlocking functions of the brain area TPJ Chapter 16: Simulating other minds Chapter 17: Some spiritual matters Chapter 18: Explaining the magic trick
A Critical Assessment of the Ecological Risk Assessment Process: A Review of Misapplied Concepts

Abstract A frank assessment of present-day ecological risk assessments (ERA) for managed contaminated sites reveals that fundamental concepts regarding the receptors that are considered and the chemical exposures they experience are commonly misapplied. As a consequence, environmental managers are not being supplied with the information needed for proper decision making. The stepwise review of ecological risk issues provided here suggests that the ERA process needs to be severely revamped. Further, what is likely hindering the development of a refined ecological assessment process that is better suited to environmental problem solving and land management is the unwillingness of stakeholders to agree that much of the current ERA practice and convention is flawed.
Collaborative interaction on large tabletop displays

We present an integration of several interface metaphors and interface components that are designed to support users interacting on large tabletop displays. These techniques— RNT, Storage bins, Interface Currents, Sticky Boards, and Sticky Notes—help solving the orientation problem on hori- zontal displays, allow to organize content on the interface in a flexible manner, and provide users with ways to annotate their objects.
Human computation

This talk is about harnessing human brainpower to solve problems that computers cannot. Although computers have advanced dramatically over the last 50 years, they still do not possess basic conceptual intelligence or perceptual capabilities that most humans take for granted. By leveraging human abilities in a novel way, I solve large-scale computational problems and collect data to teach computers basic human talents. To this end, I treat human brains as processors in a distributed system, each performing a small part of a massive computation.
Community and International Nutrition Physical Fitness, Growth and Appetite of Kenyan School Boys with Hookworm, Trichuris trichiura and Ascaris lumbricoides Infections Are Improved Four Months After a Single Dose of Albendazole1'2

We studied physical fitness with the Harvard Step Test, growth, and appetite in primary school boys infected with hookworm (96% baseline prevalence), Trichuris trichiura (98% prevalence) and Ascaris lumbricoides (41% prevalence) who received a single 600-mg dose of albendazole or an identical placebo. Boys were examined, allocated at random within pairs by descending hookworm egg count to placebo (n = 26) or albendazole (n = 27) groups, treated, and re-examined 4 mo later. Four months after treatment, the albendazole group showed highly sig nificant improvements in fitness score, resting heart rate, and heart rates at 1, 2, 3 and 4 min after the Harvard Step Test, whereas the placebo group had not changed significantly. The albendazole group also ex hibited significantly more rapid growth judged by weight gain (1.0 kg greater than the placebo group, P < 0.0002), height increment (0.6 cm more, P < 0.003), arm circumference (0.3 cm more, P < 0.0002), and triceps and subscapular skinfolds (1.0 mm more, P < 0.0002), and showed improved appetite with objective and subjective measures. We conclude that single-dose treatment with albendazole can allow improved physical fitness, growth, and appetite in school-age children in areas where these helminths and poor growth are highly prevalent. J. Nutr. 123: 1036-1046, 1993.
Anaerobic Degradation of p-Alkylated Benzoates and Toluenes

The anaerobic degradation of 4-alkylbenzoates and 4-alkyltoluenes is to date a rarely reported microbial capacity. The newly isolated Alphaproteobacterium Magnetospirillum sp. strain pMbN1 represents the first pure culture demonstrated to degrade 4-methylbenzoate completely to CO2 in a process coupled to denitrification. Differential proteogenomic studies in conjunction with targeted metabolite analyses and enzyme activity measurements elucidated a specific 4-methylbenzoyl-coenzyme A (CoA) pathway in this bacterium alongside the classical central benzoyl-CoA pathway. Whilst these two pathways are analogous, in the former the p-methyl group is retained and its 4-methylbenzoyl-CoA reductase (MbrCBAD) is phylogenetically distinct from the archetypical class I benzoyl-CoA reductase (BcrCBAD). Subsequent global regulatory studies on strain pMbN1 grown with binary or ternary substrate mixtures revealed benzoate to repress the anaerobic utilization of 4-methylbenzoate and succinate. The shared nutritional property of betaproteobacterial ‘Aromatoleum aromaticum' pCyN1 and Thauera sp. strain pCyN2 is the anaerobic degradation of the plant-derived hydrocarbon p-cymene (4-isopropyltoluene) coupled to denitrification. Notably, the two strains employ two different peripheral pathways for the conversion of p-cymene to 4-isopropylbenzoyl-CoA as the possible first common intermediate. In ‘A. aromaticum' pCyN1 a putative p-cymene dehydrogenase (CmdABC) is proposed to hydroxylate the benzylic methyl group, which is subsequently further oxidized to the CoA-thioester. In contrast, Thauera sp. strain pCyN2 employs a reaction sequence analogous to the known anaerobic toluene pathway, involving a distinct branching (4-isopropylbenzyl)succinate synthase (IbsABCDEF).
Towards bridging online game playing and live broadcasting: design and optimization

Recent years have witnessed the emergence and growth of Cloud Gaming, where players interact with the remote game instance and receive rendered game scenes in video stream. Meanwhile, broadcasting and viewing games through live streaming platforms, e.g., Twitch.tv, have become increasingly popular. The interaction and performance of the many modules involved in this new generation of gaming and streaming platforms have yet to be closely investigated. In this paper, we present an initial experiment-based performance study, in which we profile the architecture of realworld gaming and streaming platforms, namely the Open Broadcast Software (OBS) module and its connection to the Twitch server. Our investigation shows that the recording operation can greatly increase the CPU utilization and the power consumption can increase over 60% on the game streaming computer. The use of advanced hardware encoding found on modern GPUs can greatly alleviate these performance issues. Yet, through profiling, we show that hardware encoding can introduce remarkable delays to the whole pipeline. We track this to a complicated interplay between the CPUs power saving methods and the implementation of hardware encoders.
A new rate distortion model for multi-view/3D video coding

A typical scenario for multi-view 3D consists of several 3D video sequences captured simultaneously from the same scene with the help of multiple cameras from different positions and through different angles. Due to the extremely high bandwidth of multi-view/3D video, rate control is one of the key factors influencing its quality. In this paper, we investigate the impacts of multi-view/3D video characteristics on the bit rate of a compressed video and we propose an analytical view-level rate model for multi-view video coding. Our rate model takes into account both previous theoretical results as well as new results specifically obtained for multi-view video and confirmed by comprehensive practical experiments. These new results reveal a close relationship between the rate of each view and consequently the perceived quality by users, available bandwidth and processing power. Simulation results indicate that our model can predict the rate of each view with relatively high precision and a low estimation error of 20% on average.
Congruency and typicality effects in lexical decision

This thesis describes basic research into visual word recognition and decision making. Determining the best matching lexical representation for a given stimulus involves interactions between representations. The standard task for studying these processes is the lexical decision task (LDT), but there is still debate regarding the factors that affect how individuals make lexical decisions. The nature of lexical interactions and the processes underlying lexical decision-making were addressed here by testing response congruency effects in the masked priming variant of the LDT. The results of seven masked priming experiments showed a robust response congruency effect that depends on the difficulty of the word-nonword discrimination. This finding resolved apparent inconsistencies in previous research. The experiments were simulated using the Bayesian Reader and the Spatial Coding Model (SCM). The probability based Bayesian Reader model failed to accommodate the findings. However, a good fit to the data was provided by a modified version of the SCM in which the assumptions regarding the nature of lexical interactions were changed such that word nodes inhibit only (closely) related competitors. The model also assumes that the difficulty of the word-nonword discrimination affects the degree to which stimulus typicality informs lexical decisions. A critical issue for these experiments involved the definition of orthographic typicality. An algorithm for measuring orthographic typicality and for generating nonwords with a specific level of orthographic typicality (OT3) was developed. An unprimed LDT experiment showed that OT3 affected decision latency even when other standard measures of orthographic typicality were controlled. Two additional masked priming experiments showed that highly typical primes lead to faster word responses and slower nonword responses than less typical primes. Overall, the results of this research enhance our understanding of the processes underlying visual word recognition and lexical decision making, and also have important methodological implications for the field.
Modelling Collaborative Services for Business and QoS Compliance

In recent years, we witnessed a range of innovations in the ¡®service' related technologies, such as Software as a Service, Platform as a Service and Infrastructure as a Service. Along with the Service Oriented Architecture, companies can wrap their technological product as a service, to collaborate with others. Facing the ever-escalating global competition, such collaboration is crucial. The viability of this paradigm highly depends on the compliance and therefore the trustworthiness of all collaborators. However, it is challenging to achieve trustworthiness in such a dynamic cross-domain environment, as each participator may deceit for individual benefits. As a solution, we have proposed to enforce strong accountability to enhance the trustworthiness. With this accountability, incompliance can always be determined in a provable and undeniable way. In this paper, we extend our work by proposing a novel modeling of the collaborative business process. Based on this modeling, we thoroughly analyze the evidence and proving procedure needed for different types of compliance, and evaluate the extent to which those compliance can be indeed proved. We have implemented a demonstrative system to show its effectiveness in real practice.
Face-to-Face Arguing Is an Emotional Experience: Triangulating Methodologies and Early Findings

Emotional experience is important to people's understandings of interpersonal arguments. However, very little research illuminates the moment-to-moment emotionality of arguing. This project used emotional data from dyadic arguers. Arguer, partner, and coder ratings of anger, happiness, sadness, tenderness, and attitude toward the other were gathered at 30-second intervals, using a cued-recall procedure. These three ratings do not converge often or well, and appeared to be responsive to different information. Several trait instruments—measuring personalization of conflict, emotional expressivity, and emotional reappraisal/suppression—were substantially associated with the average levels of self-reported feelings. Emotions were very consistent throughout the arguments, both within and between arguers. Own feelings also were highly responsive to the whole range of the partner's emotions.
Design of Vectored Sum Defuzzification Based Fuzzy Logic System for Hovering Control of Quad-Copter

A quad-copter or quad rotor system is an unmanned flying machine having four engines, which their thrust force is produced by four propellers. Its stable control is very important and has widely been studied. It is a typical example of a nonlinear system. So, it is difficult to get a desired control performance by conventional control algorithms. In this paper, we propose the design of a vectored sum defuzzification based fuzzy logic system for the hovering control of a quad-copter. We first summarize its dynamics and introduce a vectored sum defuzzification scheme. And then we design a vectored sum defuzzification based fuzzy logic system. for the hovering control of the quad-copter. Finally, in order to check the feasibility of the proposed system we present some simulation examples.
Impact of Aortorenal Morphology on Renal Artery Stent Procedures: Significance of Aortic Tortuosity and Renal Artery Derivation

Purpose To clarify the impact of aortorenal morphology on renal artery stenting procedures. Methods A retrospective study evaluated 142 consecutive renal artery stenting procedures performed for de novo atherosclerotic renal artery stenosis in 119 patients (62 men; mean age 72±9 years, range 41–93). All procedures were done via a transfemoral approach without distal protection. Aortorenal morphology was classified into 3 types based on the relationship between abdominal aortic tortuosity and renal artery derivation. Using a straight reference line centered on the most angulated point of the inner curve of the infrarenal abdominal aorta, type 1 referred to a renal artery ostium that was more than half of the aortic diameter distance from the reference line in the greater curvature and less than half in the lesser curvature. Type 2 referred to a renal artery ostium that was less than half of the aortic diameter distant from the reference line in the greater curvature and more than half in the lesser curvature. Type 3 referred to a renal artery ostium that was beyond the reference line in the greater curvature or more than one aortic diameter from the reference line in the lesser curvature. The technical success rate, procedure time, final engagement technique, shape of the guide catheter used, and any adverse events were analyzed. Results Type 1 aortorenal morphology was observed in 91 cases, type 2 in 30, and type 3 in 21. All cases were successfully treated; there were no technical complications, in-hospital cardiovascular events, or deaths. Procedure time differed significantly (p<0.001) among the 3 types (type 1: 19.6±5.6 minutes, type 2: 23.3±6.8 minutes, and type 3: 32.3±9.6 minutes; p<0.05 for type 1 vs. 2, p<0.001 for type 2 vs. 3, and p<0.001 for type 1 vs. 3). There were also significant differences among types in terms of engagement technique and guide catheter shape. Conclusion Aortorenal morphology was significantly associated with procedure time and the selection of engagement technique and guide catheter shape.