Miracle-dz/UniFAR-FTUs huggingface dataset:
Time Trends in the Treatment and Survival of 5036 Uveal Melanoma Patients in The Netherlands over a 30-Year Period

Simple Summary Uveal melanoma (UM) is the most common eye tumor in adults. It is associated with dismal survival once metastasized. The treatment landscape has changed over the last years for the primary tumor, and new therapeutic options are being investigated for metastatic UM. However, it remains unclear if patients diagnosed in recent decades have a better survival compared to patients diagnosed in earlier decades. In this study, we use national data from patients diagnosed in the Netherlands between 1989 and 2019. We show that survival improvement was not related to the period of diagnosis but related to the treatment of the eye tumor with radiotherapy (for overall survival and cancer-specific survival) and female gender (for overall survival). Abstract Background: Uveal melanoma (UM) is a rare intraocular tumor with a dismal prognosis once metastasized. This study provides a nationwide overview and time trends of patients diagnosed with primary UM in the Netherlands between 1989 and 2019. Methods: A retrospective population-based cohort study based on patients with primary UM from the database of the Netherlands Cancer Registry (NCR), linked with the national population registry Statistics Netherlands on inhabitants’ cause of death. Two time periods (1989–2004, 2005–2019) were compared with descriptive statistics. Kaplan–Meier and (multivariate) Cox proportional hazard models were used to assess changes over time for overall survival (OS) and cancer-specific survival (CSS). Results: In total, 5036 patients were analyzed with a median age of 64.0 years at the time of diagnosis. The number of patients increased over time. In the first (1989–2004) and second (2005–2019) period, 32% versus 54% of the patients received radiotherapy (p < 0.001). The median FU time was 13.4 years. The median OS of the first and second periods was 9.5 (95% CI 8.7–10.3) versus 11.3 years (95% CI 10.3–12.3; p < 0.001). The median CSS was 30.0 years (95% CI NA) in the first period and not reached in the second period (p = 0.008). In multivariate analysis (MVA), female gender (HR 0.85; 95% CI 0.79–0.92, p < 0.001) and radiotherapy treatment (HR 0.73; 95% CI 0.64–0.83, p < 0.001) were associated with better OS. Radiotherapy treatment (HR 0.74; 95% CI 0.61–0.90, p = 0.002) was also associated with better CSS. The period of diagnosis was not associated with OS or CSS. Conclusions: In this study of patients with primary UM, there was a shift to the diagnosis of smaller tumors, possibly due to stage migration. There was also an increase in eye-preserving treatments over time. OS and CSS were modestly improved in the second time period; however, the time period was not associated with OS or CSS in multivariate analyses.
Plasma and cerebrospinal fluid proteomic signatures of acutely sleep-deprived humans: an exploratory study

Abstract Study Objectives Acute sleep deprivation affects both central and peripheral biological processes. Prior research has mainly focused on specific proteins or biological pathways that are dysregulated in the setting of sustained wakefulness. This exploratory study aimed to provide a comprehensive view of the biological processes and proteins impacted by acute sleep deprivation in both plasma and cerebrospinal fluid (CSF). Methods We collected plasma and CSF from human participants during one night of sleep deprivation and controlled normal sleep conditions. One thousand and three hundred proteins were measured at hour 0 and hour 24 using a high-scale aptamer-based proteomics platform (SOMAscan) and a systematic biological database tool (Metascape) was used to reveal altered biological pathways. Results Acute sleep deprivation decreased the number of upregulated and downregulated biological pathways and proteins in plasma but increased upregulated and downregulated biological pathways and proteins in CSF. Predominantly affected proteins and pathways were associated with immune response, inflammation, phosphorylation, membrane signaling, cell-cell adhesion, and extracellular matrix organization. Conclusions The identified modifications across biofluids add to evidence that acute sleep deprivation has important impacts on biological pathways and proteins that can negatively affect human health. As a hypothesis-driving study, these findings may help with the exploration of novel mechanisms that mediate sleep loss and associated conditions, drive the discovery of new sleep loss biomarkers, and ultimately aid in the identification of new targets for intervention to human diseases.
Aerial Photogrammetry by drone in archaeological sites with large structures. Methodological approach and practical application in the medieval castles of Campo de Montiel

By writing this article we aim to illustrate the interesting combination of two existing techniques, accessible both for research groups and for professionals who want to study archaeological heritage: photogrammetry and aerial photography using a drone. We have applied these techniques to archaeological sites with standing structures, such as medieval castles in “Campo de Montiel” (Ciudad Real). Based on our expertise and experience, we have developed methodology for surface archaeological research, excavation and wall stratigraphy, thus identifying positive and negative aspects of this ethodology. The results obtained are truly positive, as we generated high-quality images offering news opportunities to investigate and show results, saving a considerable amount of time and money compared to traditional methods for graphical documentation.
INDUCCION DE EMBRIONES SOMATICOS A PARTIR DE HOJAS DE Capsicum chinensis, UTILIZANDO DIFERENTES CONCENTRACIONES DE 2,4-DICLOROFENOXIACÉTICO Y 6-BENCIL AMINO PURINA

RESUMEN Capsicum chinensis L. conocido como ―Aji Panca‖ es util por sus propiedades pungentes y aromaticas; en seco se le utiliza, como base para las salsas y pastas, estimulante digestivo, sazonador y como antioxidante en carnes y otros; lo que demuestra ser un recurso de amplisimo rango de aprovechamiento para su industrializacion y menor perdida con relacion al fruto fresco. La experiencia se inicio con la siembra de semillas en macetas con tierra preparada y musgo. A los 25 dias se introdujo dos pedazos de hojas jovenes en medio basal (MS) con 2,4 –D a 1ppm y 0.5 ppm. Los callos obtenidos fueron traspasados a un nuevo medio suplementado con 2,4-D y BAP. Los resultados muestran que los callos embriogenicos se desarrollaron mejor en 1 ppm de 2,4 –D con un 76 % de desarrollo a los 16 dias. El mejor tratamiento, para el desarrollo de los embriones, fue el de 5ppm de BAP a los 56 dias de estar en dicho tratamiento. Ademas, se observo las diferentes etapas globular, acorazonada, torpedo, por las que pasa el embrion. Se concluye que la mejor combinacion para la induccion de embriones somaticos en Capsicum chinensis es la de 1ppm de 2,4-D para formar callos embriogenicos y 5ppm de BAP en el crecimiento del embrion. Palabras claves: Capsicum chinensis, 2,4 – Diclorofenoxiacetico (2,4 –D), Bencil amino purina (BAP), Embriogenesis ABSTRACT Capsicum chinensis L. , known as "Aji Panca", is useful for its pungent and aromatic properties; it is used in dry conditions as a base for sauces and pastas, it is a digestive stimulant and an antioxidant in seasoning meats and others; what proves to be a very wide range useful resource for industrialization and lower loss compared to fresh fruit. The experience started with seeds sowing in pots with prepared soil and moss. At 25 days two pieces of young leaves were introduced into basal medium (MS) with 2, 4-D at 1 ppm and 0.5 ppm. The calli were transferred to a new supplemented medium with 2, 4-D and BAP. The results show the embryogenic callus best developed to 1 ppm of 2, 4-D with a 76% growth at 16 days. The best treatment, for the embryos development, was 5 ppm BAP, 56 days of being in treatment. Also It was observed different stages, globular, heart-shaped, torpedo in the embryos process. This research concludes that the best combination for the induction of somatic embryos in Capsicum chinensis is 1 ppm of 2, 4-D to form embryogenic callus and 5ppm BAP to embryo growth. Keywords: Capsicum chinensis, 2, 4- dichlorophenoxyacetic acid (2,4-D), Benzyl amino purine (BAP), embryogenesis Recibido: 05 de Mayo de 2014 Aceptado: 01 de Agosto de 2014
Automated photo-identification of cetaceans : An integrated software solution

This study investigates current techniques used for automated photoidentification of cetaceans (i.e. dolphins and whales). The primary focus constitutes various techniques that can be applied to identify and extract dorsal fins from digital photographs. A comprehensive analysis of these techniques demonstrates the most effective software solution. To further support this analysis, four prototypes are developed to demonstrate the effectiveness of each technique in a practical environment. The analysis bases its final conclusions on test results generated from these prototype software examples. Final conclusions provide recommendations for an effective, accurate, and practical software solution. This software solution allows dorsal fins to be easily extracted from digital photographs and identified through the use of computer automated methods.
Clarifying the Pulmonary Arterial Morphology and Pulmonary Blood Supply in Patients with Tetralogy of Fallot and Pulmonary Atresia on Computed Tomography Angiography

Aim. The present study sought to characterize the pulmonary arterial morphology and pulmonary blood supply in patients of tetralogy of Fallot and pulmonary atresia (TOF-PA) on CT angiography. Materials and Methods. We retrospectively reviewed our departmental database to identify patients with TOF-PA evaluated using CT angiography. The images were analysed to detect the presence of main and branch pulmonary arteries and pulmonary arterial confluence, presence of major aortopulmonary collateral arteries (MAPCAs), laterality and relation with pulmonary arterial morphology, and presence of patent arterial duct and associated intra- and extracardiac anomalies. Results. TOF-PA was identified in 177 patients (114 (64.4%) males; median age: 9 months). Pulmonary arteries were confluent in 142/177 (80.2%) patients. According to Somerville classification, type II pulmonary atresia was the most frequent pattern seen in 127/177 (71.8%). Based on McGoon’s ratio, pulmonary arteries were adequate for surgery in 123/177 (69.5%) patients. Patent arterial duct was present in 84/177 (47.5%) patients while MAPCAs were present in 124 (70.1%) patients, of which 72/124 (58.1%) patients had at least 1 essential MAPCA supplying either lung. According to Congenital Heart Surgeons’ Society classification, type B pulmonary arterial anatomy was the most prevalent, seen in 103/177 (57.6%) patients. Conclusion. TOF-PA is associated with marked morphologic variability in the pulmonary arterial arborization to supply the lungs. Cardiac CT angiography can accurately delineate the pulmonary arterial morphology, sources of pulmonary blood supply, and associated cardiovascular anomalies in patients with TOF-PA which aids in planning appropriate surgical management including decisions regarding the need for unifocalization of MAPCAs.
Job Stress of Tourism Industry Employees Due to Covid-19

The tourism industry has been badly affected by the Covid 19 pandemic. The policy of limiting tourism travel activities has led to uncertainty in the tourism business. Besides, tourism industry workers are at high risk of contracting the Covid 19 virus because tourism services must be done directly with tourists. Many workers in the tourism industry experience work stress due to the Covid 19 pandemic. This systematic literature review study examines tourism worker stress due to the Covid 9 pandemic. The literature review method uses a cross-sectional search of health, tourism, and management articles. The search results were eight articles selected by Prisma Chart with defined inclusion and exclusion criteria. The results of a systematic literature review study revealed that the perceived threat of the Covid 19 virus causes fear and worry about being infected. Another factor that causes stress for tourism workers regarding job insecurity is perceived uncertain job continuity. Experienced work stress has an impact on decreasing job satisfaction and well-being, then can increase the turnover intention of workers from the company. Several strategies can be implemented to reduce work stress by providing self-protection tools, service rules, adjusting work assignments, and preparing transformational leadership to increase the company's resilience in facing various external conditions.
Feature Selection for Portable Spectral Sensing Data of Soil Using Broad Learning Network in Fusion With Fuzzy Technique

Urban sensing has become prevalent for monitoring dynamic urban status due to the development of intelligent computing. Fast sensing and accurate analysis of soil quality promote data-driven urban planning and management. Soil contamination hiders the sustainable development of the city’s environmental ecology. Decentralized sensing based on an Internet of Things (IoTs) architecture is a state-of-art technology. Portable spectral detection serves for immediate quantitative analysis of target components. In this case, portable sensing combined with federated learning simply shares the informative features extracted from the IoT-based spectral sensing data. However, the modeling technique for the analysis of spectroscopic sensing data faces several challenges due to the emerge of the big data problem in IoT-based sceneries. The consideration of possible federal learning of multinode collective data should ask for deep studies of modeling methodologies. In this article, we built up an IoT-based portable spectral sensing system for simultaneous sensing and detecting soil data at distributed sensing places. The collaborative training model was established for dealing with the dynamic sensing data, by the fusion design of a broad learning network (BLN) and a fuzzy partial least square (fPLS) model. The BLN output feature variables are produced from the scalable pseudo input layer with training linking weights adaptively, and the number of fuzzy rules is scalable. In the experiment, the decentralized sensing system and the fusion modeling framework carry out the model optimization for the portable near-infrared (NIR) spectroscopic sensing data of heavy metals in soil samples. The quantification of two elements demonstrated that the proposed framework yielded superior prediction results to the conventional PLS model for the training and evaluation of the dynamic sensing data. In interaction with the IoT architecture, the framework is prospectively expected as an advanced intelligent technical support for fast analysis of portable spectroscopic sensing data.
Teleconsultation for Children With Developmental Disabilities During the Coronavirus Pandemic: Caregivers’ Experience

Background The unprecedented situation due to the coronavirus disease 2019 (COVID-19) lockdown necessitated the need for teleconsultations with caregivers of children with disabilities. The objective of this study was to explore the acceptability, satisfaction, perceived relevance, and barriers to teleconsultation from a caregiver’s perspective. Methodology This was a descriptive qualitative study (telephonic interviews) involving in-depth interviews (IDIs) with the caregivers of children with developmental disabilities who received teleconsultations. Manual content analysis of transcripts of IDIs was done. Results Eight IDIs were conducted with the caregivers of children with cerebral palsy, autism, and developmental delay. The respondents expressed increased challenges in managing their children during the pandemic and the need for professional consultation. They also expressed difficulty in accessing professional help during the pandemic due to poor healthcare access and fear of getting COVID-19. The following responses were noted: “For almost a year we couldn’t take her for the therapy,” “We were unable to take him to therapy which resulted in an increase in tightness of his limbs, and he became more irritable. ” All respondents preferred video teleconsultations during lockdown due to flexible timings, ease of communication, and no travel restrictions; “I can benefit from teleconsultation because she does not have any physical problem. ” However, caregivers of children with physical ailments preferred face-to-face consultation. Conclusions Teleconsultation was found to effectively support the treatment and rehabilitation of children with disabilities during the COVID-19 lockdown, although direct face-to-face consultation was preferred by caregivers of children with physical ailments. The use of modern mobile/digital technologies creates new opportunities to improve the quality and accessibility of such services.
Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose

A quantitative assessment of silver nanoparticles (AgNPs) in fluids and some organs of pregnant rats as well as their fetal blood were carried out in this study. A single oral dose (1mg/kg) of AgNPs with a size range of 4-20 nm was administered to pregnant rats on the 19th of gestation. Five groups were euthanized after 10 min, 1, 6, 12, and 24 hr as well as the control group. Total Silver (Ag) contents were measured in bloods (maternal and fetal) and several organs using Inductive Coupled Plasma Optical Emission Spectroscopy (ICP-OES) followed by acid digestion. In maternal blood, AgNPs were found to increase time-dependently after 12 and 24 hr into 0.135 and 0.224 μg/ml, but it was slightly higher in fetal blood (0.32 and 0.31 μg/ml) after 10 min and 1 hr. In other samples: kidneys, liver, spleen, placenta, and uterus the data indicated that NPs were rapidly absorbed from the dosing site (gastrointestinal tract) as evidenced by the detection of Ag in the analyzed samples (fluids and tissues). On the other hand, the cumulative percentages of excretion level in urine was 8.25% which was higher than in feces (4.77%) after 24 hr. These findings indicate the ability of AgNPs to accumulate in pregnant rats and transfer to their fetus imposing adverse outcomes and male formation. Thus, further investigations must be followed for direct and/or indirect exposure to such NPs before decision for their practices.
Projecting Future-Year Pollutant Emissions: Emerging Approaches from the EPA ORD Global Change Air Quality Assessment

The U.S. EPA’s Office of Research and Development is exploring approaches for assessing the relative impacts of climate and emissions changes on future-year air quality. A challenge related to this effort is the development of emission inventories out to the year 2050. This paper describes a methodology that is under development. The methodology allows consideration of various assumptions regarding population growth and migration, economic growth, technological change, fuel resource constraints, and pollutant emissions policies.
Strain localization and fluid migration from earthquake relocation and seismicity analysis in the western Vosges (France)

SUMMARY To understand the mechanisms of intraplate earthquakes, well-documented seismological and geodynamical studies are needed, to provide information for adequate mechanical modelling. This paper describes a detailed analysis of the earthquake sequence associated with the Rambervillers (France) M ∼ 5.4 earthquake (2003 February 22), which occurred in the western Vosges massif (France), some tens of kilometres to the north of the sites of the Epinal (1973–1974) and Remiremont (1984–1985) earthquake sequences. We computed the location of the mainshock and focal mechanism, together with the double-difference locations of 419 aftershocks of the subsequent earthquake sequence, which included 195 well-recorded similar events (earthquakes with similar waveforms). We combined pP phases recorded by remote dense seismic networks with waveform modelling, to accurately determine the mainshock depth (12.5 ± 1.5 km). Computations of focal mechanisms from regional waveform inversions showed a normal fault plane with a N315 ◦ ± 10 ◦ strike and a 45 ◦ ± 15 ◦ dip. A detailed space–time analysis allowed two earthquake sequences to be identified: a classic mainshock–aftershock sequence and a secondary sequence that began 250 days after the mainshock. More events were recorded during the secondary sequence than during the main sequence. Very few similar events were recorded during the first 2 days after the mainshock, although data were recorded continuously. Double-difference locations from traveltime differences show that these immediate, non-similar aftershocks occurred in a 4 km × 2k m subhorizontal area at a depth of about 12 km. Similar events were far more numerous during the secondary earthquake sequence. Double-difference relocation of these similar events revealed a N315 ◦ striking, 65 ◦ dipping fault plane that is compatible with the mainshock source mechanism. During this later sequence, seismicity oscillated over a vertical range of 2–3 km around a mean depth of approximately 12 km. This observation strongly suggests fluid migration. Normal faulting, subhorizontal faulting and fluid transfer at about 12 km depth can be interpreted in terms of the crust’s response (mainshock and post-seismic relaxation) to flexural stresses induced by the alpine compression. This relaxation involves weakening and collapse of the crust, and fluid transfer.
Dual-Polarized Magneto-Electric Dipole for 5G 28-GHz Phased Array Applications

A low-profile dual-polarized magneto electric (ME) dipole antenna configuration implemented on standard multilayer PCB technology is here reported. The proposed radiator is conceived for dual-polarized 28 GHz 5G phased array applications. Wideband operation is achieved by applying several low-frequency techniques which allow to fulfil the 5G requirements without increasing the dielectric core thickness. A $4\times8$ ME-dipole phased array is then designed, fabricated, and tested. The measured beam scanning range without the blindness in the E-plane is ±55° for the vertical polarization. Stable radiation patterns and a gain of up to 22 dBi are also achieved. The thickness of the antenna layers is significantly lower with respect to the other configurations in the literature while providing similar performance. Having reduced the antenna core thickness results in a structurally balanced stack-up, lighter and easier to fabricate with high yield. In addition, high isolation between the elements allows superior beam scanning performances. The proposed design is well suited to both packaging technologies and standard PCB processes and is an attractive candidate for the millimeter-wave applications in the fifth generation (5G) mobile systems.
A Smart Helmet Framework Based on Visual-Inertial SLAM and Multi-Sensor Fusion to Improve Situational Awareness and Reduce Hazards in Mountaineering

Sensitivity to surrounding circumstances is essential for the safety of mountain scrambling. In this paper, the authors present a smart helmet prototype equipped with visual SLAM (simultaneous localization and mapping) and barometer multi-sensor fusion (MSF), IMU (inertial measurement unit), omnidirectional camera, and global navigation satellite system (GNSS). They equipped the helmet framework with SLAM to produce 3D semi-dense pointcloud environment maps, which are then discretized into grids. Then, the novel danger metrics they proposed were calculated for each grid based on surface normal analysis. The A* algorithm was applied to generate safe and reliable paths based on minimizing the danger score. This proposed helmet system demonstrated robust performance in mapping mountain environments and planning safe, efficient traversal paths for climbers navigating treacherous mountain landscapes.