Miracle-dz/UniFAR-FTUs huggingface dataset:
The importance of patient expectations in predicting functional outcomes after total joint arthroplasty.

OBJECTIVE To evaluate the relationship between patient expectations of total joint arthroplasty (TJA) and health related quality of life plus satisfaction 6 months after surgery. Methods. This prospective cohort study included patients undergoing primary total hip (THA) and knee arthroplasty (TKA). Patients were evaluated with self-report questionnaires prior to surgery and 6 months post-surgery. Medical Outcomes Study Short Form 36 (SF-36), the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), and a satisfaction scale were used to evaluate outcomes at final followup. Multivariate regression models were used to evaluate the impact of expectations on outcomes. RESULTS There were 102 patients with THA and 89 with TKA. Mean age was 66 years. All patients achieved significant improvements in their WOMAC and SF-36 scores following surgery. Patient expectations regarding surgery were not associated with their age, gender, index joint of surgery, marital status, or race. Expectations were not correlated with pre-operative functional health status. Expectation of complete pain relief after surgery was an independent predictor of better physical function and improvement in level of pain at 6 months post-surgery. Expectation of low risk of complications from TJA was an independent predictor of greater satisfaction. CONCLUSIONS Patient expectations were important independent predictors of improved functional outcomes and satisfaction following TJA. Greater understanding of the relationship between expectations and outcomes may improve the process of care and outcomes of TJA.
Substantial differences in initiation of oral anticoagulant therapy and clinical outcome among non-valvular atrial fibrillation patients treated in inpatient and outpatient settings.

AIMS Patients with atrial fibrillation (AF) are encountered and treated in different healthcare settings, which may affect the quality of care. We investigated the use of oral anticoagulant (OAC) therapy and the risk of thrombo-embolism (TE) and bleeding, according to the healthcare setting. METHODS AND RESULTS Using national Danish registers, we categorized non-valvular AF patients (2002-11) according to the setting of their first-time AF contact: hospitalization (inpatients), ambulatory (outpatients), or emergency department (ED). Event rates and hazard ratios (HRs), calculated using Cox regression analysis, were estimated for outcomes of TE and bleeding. We included 116 051 non-valvular AF patients [mean age 71.9 years (standard deviation 14.1), 51.3% males], of whom 55.2% were inpatients, 41.9% outpatients, and 2.9% ED patients. OAC therapy 180 days after AF diagnosis among patients with a CHADS2 ≥ 2 was 42.1, 63.0, and 32.4%, respectively. Initiation of OAC therapy was only modestly influenced by CHADS2 and HAS-BLED scores, regardless of the healthcare setting. The rate of TE was 4.30 [95% confidence interval (CI) 4.21-4.40] per 100 person-years for inpatients, 2.28 (95% CI 2.22-2.36) for outpatients, and 2.30 (95% CI 2.05-2.59) for ED patients. The adjusted HR of TE, with inpatients as reference, was 0.74 (95% CI 0.71-0.77) for outpatients and 0.89 (95% CI 0.79-1.01) for ED patients. CONCLUSION In a nationwide cohort of non-valvular AF patients, outpatients were much more likely to receive OAC therapy and had a significantly lower risk of stroke/TE compared with inpatients and ED patients. However, across all settings investigated, OAC therapy was far from optimal.
Maintenance of Type a Behavior: Support for a Type-Similarity Hypothesis

This study tested two hypotheses that might account for the maintenance of the Type A behavior pattern. 56 male and 56 female Type A and B subjects rated the attractiveness of a stimulus person described as a Type A male, Type A female, Type B male, or Type B female. Type A subjects preferred the Type A stimulus person, while Type B subjects were mote attracted to the Type B stimulus person. These findings supported a type-similarity hypothesis.
Diabatic ordering of vibrational normal modes in reaction valley studies

Diabatic ordering of the normal model of a reaction complex along the reaction path has several advantages with regard to adiabatic ordering. The method is based on rotations of the vibrational normal modes at one point, s, of the reaction path to maximize overlap with the vibrational modes at a neighboring point. Global rotations precede the rotations of degenerate modes so that changes in the direction of the reaction path and changes in the force constant matrix, which represent the two major effects for changes in mode ordering, can be separated. Overlap criteria identify resolved and unresolved avoided crossings of normal modes of the same symmetry. Diabatic mode ordering (DMO) can be used to resolve the latter by reducing the step size, thus guaranteeing correct ordering of normal modes in dependence of s. DMO is generally applicable to properties of the reaction complex that depend on s such as normal mode frequencies, orbital energies, the energy of excited states, etc. Additional applications are possible using a generalized reaction path vector, which may describe the change in atom masses, geometrical parameters, and/or the force constant matrix. In this way, the vibrational spectra of isotopomers can be investigated or the vibrational frequencies of different molecules correlated. © 1997 John Wiley & Sons, Inc. J Comput Chem 18: 1282–1294, 1997
A Stable Twin-Core-Fiber-Based Integrated Coupler Fabricated by Thermally Diffused Core Technique

A type of stable integrated couplers based on the twin-core fiber (TCF) is proposed and demonstrated. The integrated coupler is fabricated by heating a piece of TCF with the thermally diffused core technique. During the heating process, the dopant in the cores of the TCF will diffuse to the cladding which leads to expansion of the core mode fields. As a result, the optical power in the two cores can be coupled to each other. Because the external shape of the coupling region of the TCF coupler does not change, such type of couplers have high mechanical strength and stable responses to temperature, strain, and surrounding refractive index changes. The coupling characteristics between the cores of the thermally diffused TCF are theoretically analyzed and experimentally investigated. Results show that the coupler is almost stable when the temperature changed from 30 to 120 °C, the strain changed from <inline-formula> <tex-math notation="LaTeX">$0\;{{\mathbf \mu \varepsilon }}$</tex-math></inline-formula> to <inline-formula> <tex-math notation="LaTeX">$1923\;{{\mathbf \mu \varepsilon }}$</tex-math></inline-formula>, and the external refractive index ranged from 1.3435 to 1.3676.
Methotrexate in the treatment of pemphigus vulgaris: experience in 23 patients

The standard treatment for patients with pemphigus vulgaris has long consisted of high‐dose glucocorticoids. Studies regarding the use of methotrexate in pemphigus vulgaris date back to 1968, but few have quantitatively described a steroid‐sparing effect conferred by methotrexate.
HARO7 Encodes Chorismate Mutase of the Methylotrophic Yeast Hansenula polymorpha and Is Derepressed upon Methanol Utilization

ABSTRACT The HARO7 gene of the methylotrophic, thermotolerant yeast Hansenula polymorpha was cloned by functional complementation. HARO7 encodes a monofunctional 280-amino-acid protein with chorismate mutase (EC 5.4.99.5 ) activity that catalyzes the conversion of chorismate to prephenate, a key step in the biosynthesis of aromatic amino acids. The HARO7 gene product shows strong similarities to primary sequences of known eukaryotic chorismate mutase enzymes. After homologous overexpression and purification of the 32-kDa protein, its kinetic parameters (kcat = 319.1 s−1,nH = 1.56, [S]0.5 = 16.7 mM) as well as its allosteric regulatory properties were determined. Tryptophan acts as heterotropic positive effector; tyrosine is a negative-acting, heterotropic feedback inhibitor of enzyme activity. The influence of temperature on catalytic turnover and the thermal stability of the enzyme were determined and compared to features of the chorismate mutase enzyme of Saccharomyces cerevisiae. Using the Cre-loxP recombination system, we constructed mutant strains carrying a disrupted HARO7 gene that showed tyrosine auxotrophy and severe growth defects. The amount of the 0.9-kbHARO7 mRNA is independent of amino acid starvation conditions but increases twofold in the presence of methanol as the sole carbon source, implying a catabolite repression system acting onHARO7 expression.
Novel Clique enumeration heuristic for detecting overlapping clusters

There are several known methods for detecting overlapping communities in graphs, each one having their advantages and limitations. The Clique Percolation Method (CPM) is one such method. CPM works by joining highly connected subgraphs (cliques) and using it to find the graph communities. However, the clique enumeration problem is NP-Hard, taking exponential time to be solved. This makes its use impractical in large real-world networks and applications. The aim of this paper is to present an efficient heuristic to enumerate cliques. This enables the Clique Percolation Method to detect overlapping communities in networks containing thousands of nodes. The analyses showed that our novel heuristic is competitive with other known methods regarding solution quality and we also make the CPM more scalable.
Study on Micro Segregation of High Alloy Fe–Mn–C–Al Steel

The segregation patterns of solute elements in the Fe–17.1Mn–0.24C–1.38Al steel are systemically investigated by experiments and simulations. The electron probe microanalyzer (EPMA) is conducted to assess possible micro segregation. The result indicates that with the increase of solid fraction in dendrite arms, Mn shows a positive segregation tendency, C uniformly distributes, and Al content slightly fluctuates. Compared with micro segregation models, experimental results of C match well with the Brody‐Fleming model. The segregation ratios of Mn are in good agreement with the lever‐rule. There is no certain regularity displayed between the experimental and calculation results about the segregation ratios of Al. The matrix of the steel is inhomogeneous with severe Mn and C micro segregation in the inter dendritic zone, whereas Al shows the opposite trend. A multicomponent phase field method coupled to thermodynamic calculations is used to simulate the concentration profiles of solute elements in the dendrite arms, and the numerical results are in favorable agreement with the experimental ones. Finally, the roles of undercooling and cooling rate on dendrite morphology and micro segregation of Mn are investigated. It reveals that large undercoolings could improve Mn segregation, while cooling rates have little effect on the maximum Mn segregation concentration but contribute to reduce the total inter dendritic Mn amount. They both have refinement effects on the dendritic structure. Those are helpful to understand and improve the segregations in Fe–Mn–C–Al steels.
Think Piece: Preparing today’s children for the workplaces of tomorrow: The critical role of STEM education

Three reports released in the last few months have highlighted the rapid transformation of the workplace that will impact on the students currently within our schools (CEDA, 2015; Delotte Access Economics, 2015; PwC, 2015). Many of the jobs these students will undertake when they graduate from schools, vocational and higher education do not exist yet. These reports make for arresting reading, and require educators to reflect deeply on the competencies that will be required of our students if they are to successfully navigate the changing employment landscape and a society increasingly reliant on science and technology.
The 2015 Ukraine Blackout: Implications for False Data Injection Attacks

In a false data injection attack (FDIA), an adversary stealthily compromises measurements from electricity grid sensors in a coordinated fashion, with a view to evading detection by the power system bad data detection module. A successful FDIA can cause the system operator to perform control actions that compromise either the physical or economic operation of the power system. In this letter, we consider some implications for FDIAs arising from the late 2015 Ukraine Blackout event.
Studying the Roots of Anomie in Iran before Islamic Revolution (With a Glance to France and USA)

Anomie is a negative consequence of modernization. Naturally, one should more or less observe anomie in a society after its modernization. However, mildness or seriousness of anomie depends on how to modernize, in that anomie in western countries (especially France and USA) has more limited negative consequences because of their internal and gradual modernization that third world countries (like Iran) due to their external and sudden modernization. The reason is clear. In fact, internal and incremental modernization phenomenon in western countries has created a kind of coordination between culture and technology so that one can say that culture directs technology rather than technology supports culture while in developing countries like Iran, there is a conflict between local and imported technology due to external and sudden nature of technology. This conflict apparently led into scattering some traditional norms so that in contrary to western countries, it was the technology which directs culture rather than cultures supports technology!
Peri-ictal Water Drinking : An Interesting Phenomenon With Unknown Reason

Peri-ictal Water Drinking: An Interesting Phenomenon With Unknown Reason Ebru ALTINDAĞ, Erhan ERTEKİN, Ayşen GÖKYİĞİT, Banu ASLANTAŞERTEKİN, Ebru Nur VANLI-YAVUZ, Sevda ÖZEL YILDIZ, Nerses BEBEK, Candan GÜRSES, Işın BARALKULAKSIZOĞLU, Betül BAYKAN İstanbul Florence Nightingale Hastanesi, Nöroloji Bölümü, Şişli/İstanbul, Turkey İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İstanbul Tıp Fakültesi, Psikiyatri Anabilim Dalı, Çapa/ İstanbul, Turkey İstanbul Üniversitesi, İsatanbul Tıp Fakültesi, Nöroloji Anabilim Dalı, Çapa/ İstanbul, Turkey İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Çapa/ İstanbul, Turkey
Forecasting Inflation Using Dynamic Model

We forecast quarterly US ination based on the generalized Phillips curve using econometric methods which incorporate dynamic model averaging. These methods not only allow for coe¢ cients to change over time, but also allow for the entire forecasting model to change over time. We nd that dynamic model averaging leads to substantial forecasting improvements over simple benchmark regressions and more sophisticated approaches such as those using time varying coe¢ cient models. We also provide evidence on which sets of predictors are relevant for forecasting in each period. Keywords: Bayesian, State space model, Phillips curve JEL Classi cation: E31, E37, C11, C53 We would like to thank participants at the 20th EC2 Conference in Real-Time Econometrics, the 6th EUROSTAT Colloquim on Modern Tools for Business Cycle Analysis, the European Central Bank, the Bundesbank, the Bank of England and the Universities of Aarhus, Cambridge, Lancaster, Namur and Queen Mary for helpful comments. This research was supported by the ESRC under grant RES-062-232646. Both authors are Fellows at the Rimini Centre for Economic Analysis. yCorresponding author, Department of Economics, University of Strathclyde, 130 Rottenrow, Glasgow G4 0GE, UK. Email: Gary.Koop@strath.ac. uk
Protective capacity of cercarial transformation fluid alone or in combination with crude cercarial antigen against challenge infections of Schistosoma mansoni in mice

Abstract Schistosomiasis is the second major parasitic disease in the world after malaria. It affects 201.5 million cases in Africa alone. The aim of this research was to explore alternative vaccination strategies against experimental schistosomiasis mansoni. We assessed the effect of cercarial transformation fluid (CTF) singly and in combination with crude cercarial antigen (CCA) using alum as an adjuvant. The combined antigens gave the best results, as evidenced by a significant reduction in the worm load (62.07%), tissue egg count (78.16%, 86.46%) in liver and intestine respectively, and hepatic granuloma size (29.96%). Scanning electron microscopy revealed changes in the tegument, in the form of roughness and appearance of vesicles and furrows between the tegumental tubercles. Also, resorption of the ventral sucker and dimples replacing its spines were observed. The female tegument was irregular and its posterior end showed loss of spines and sensory bulbs. Moreover, there was a significant decrease in liver enzymes (alanine transaminase (ALT) and aspartate transaminase (AST)) compared to infected control mice. A significant elevation in CD4+T-lymphocytes, denoting amelioration of the immune status, in mice that received combined antigens was also observed. It can be concluded that combined antigens demonstrate potential as a vaccine against Schistosoma mansoni.
sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation.

PURPOSE sigma-1 Receptor ligands prevent neuronal death associated with glutamate excitotoxicity both in vitro and in vivo. However, the molecular mechanism of the neuroprotective effect remains to be elucidated. The present study was undertaken to determine whether sigma-1 receptor agonists provide neuroprotection by decreasing glutamate-induced calcium mobilization and preventing apoptotic gene expression. METHODS Cell death was measured by using a calcein-AM/propidium iodide cell-survival assay. Western blot analysis determined the expression levels of Bax in normal RGC-5 cells. Caspase-3 activation after glutamate treatment was determined with a carboxyfluorescein caspase-3 detection kit. Glutamate-induced intracellular calcium mobilization was measured by using ratiometric calcium imaging. RESULTS sigma-1 Receptor-overexpressing RGC-5 (RGC-5-S1R) cells had lower glutamate-induced intracellular calcium mobilization than did normal RGC-5 cells, and the sigma-1 receptor ligand (+)-SKF10047 reduced the glutamate calcium response in normal and RGC-5-S1R cells. (+)-SKF10047 protected RGC-5 cells from glutamate-induced cell death, and the RGC-5-S1R cells showed a significant resistance to glutamate-induced apoptosis compared with the control RGC-5 cells. BD1047, a sigma-1 receptor antagonist, blocked the protective effect of (+)-SKF10047. Western blot analysis showed that (+)-SKF10047 inhibited the increase in Bax after glutamate treatments. Glutamate-mediated cell death involved activation of caspase-3, and sigma-1 receptor activation prevented an increase in caspase-3 expression. CONCLUSIONS The results suggest that sigma-1 receptors regulate intracellular calcium levels and prevent activation of proapoptotic genes, thus promoting retinal ganglion cell survival. The sigma-1 ligands appear to be neuroprotective and are a potential target for neuroprotective therapeutics.
Two-hydrophone heading and range sensor applied to formation-flying for AUVs

One form of cooperative behavior for a group of AUVs is to fly in formation while performing tasks. A necessary component for formation-flying is that the vehicles must sense their relative positions. Assuming that each vehicle is capable of sensing its inertial position, using an acoustic long-baseline ranging system, the relative vehicle position can be determined by exchanging this data. The penalty for this approach is that exchanging inertial position data consumes communications bandwidth. Alternately, relative position may be obtained by intercepting acoustic ranging signals used to determine inertial position, obviating the need for exchange of position data. We explore the use of a two-hydrophone sensor to measure relative heading of two vehicles in a formation. It is assumed that a broad-band navigation signal emanating from one vehicle is intercepted by another vehicle containing the sensor. Relative heading is extracted from the time delay between the two hydrophones. Cross-correlation is used to determine time delay. A model is proposed that predicts stochastic precision and bias for the sensor. For a fixed ranging waveform, precision and bias are dependent upon signal-to-noise ratio, relative range and relative heading. This dependence means that the sensor will be most useful for certain combinations of range and heading. Measurements were performed to determine the precision of the two-hydrophone arrangement as a relative heading sensor. Simulations were used to explore the performance of formation-flying controllers that employ the two-hydrophone sensor. The controller used a saturating linear output feedback control law to simultaneously follow inertial waypoints and maintained formation. The simulations showed that this controller would be able to use relative heading provided by the two-hydrophone sensor to maintain formations in which the vehicles are approximately abreast
Work–family balance in international perspective

In recent academic debates on work–family balance, there has frequently been a disparity between theory and practice. With ageing populations globally, it is expected that both men and women will work later into life, and greater effort is needed on the part of governments and families to ensure care and support for elderly and disabled people. These factors combine to make the relationship between work and care a crucial issue for social and employment policy. The books by Milkman and Appelbaum as well as Kroger and Yeandle discuss care comprehensively and extend current debates on the relationship between the policy context and human agency. They highlight the policy lessons to be learned from experiences of the reconciliation of work and care in various contexts. Unfinished Business by Ruth Milkman and Eileen Appelbaum investigates California’s Paid Family Leave (PFL) programme, implemented in mid-2004. This programme was designed to address the need for paid family leave and to assist, among other groups, the ‘sandwich generation’ – working people with caregiving responsibilities both to elderly parents and to their own young children. This book reports the results of four original surveys conducted in 2004, just prior to the introduction of the PFL programme, and in 2009. The programme came into force in July 2004, and provides eligible male and female workers with six weeks of PFL per year for caring for a new child or a seriously ill relative. PFL covers all private and non-profit workers and these employees receive up to 55% of their weekly wages. The programme is financed by an employee payroll tax and is administered by California’s Employment Development Department, together with the Temporary Disability Insurance (TDI) programme. Milkman and Appelbaum supplement the survey results with recent statistical data from California, and analyse the 604568WES0010.1177/0950017015604568Work, employment and societyJoint book review research-article2015