Miracle-dz/UniFAR-FTUs huggingface dataset:
Entamoeba moshkovskii Infections in Children in Bangladesh

Entamoeba moshkovskii cysts are morphologically indistinguishable from those of the disease-causing species E. histolytica and the nonpathogenic E. dispar. Although sporadic cases of human infection with E. moshkovskii have been reported, the organism is considered primarily a free-living ameba. No simple molecular detection tool is available for diagnosing E. moshkovskii infections. We used polymerase chain reaction (PCR) to detect E. moshkovskii directly in stool. We tested 109 stool specimens from preschool children in Bangladesh by PCR; 17 were positive for E. histolytica (15.6%) and 39 were positive for E. dispar (35.8%). In addition, we found that 23 (21.1%) were positive for E. moshkovskii infection, and 17 (73.9%) of these also carried E. histolytica or E. dispar. The high association of E. moshkovskii with E. histolytica and E. dispar may have obscured its identification in previous studies. The high prevalence found in this study suggests that humans may be a true host for this ameba.
Monitoring Driver's Alertness Based on the Driving Performance Estimation and the EEG Power Spectrum Analysis

Preventing accidents caused by drowsiness behind the steering wheel is highly desirable but requires techniques for continuously estimating driver's abilities of perception, recognition and vehicle control abilities. This paper proposes methods for drowsiness estimation that combine the electroencephalogram (EEG) log subband power spectrum, correlation analysis, principal component analysis, and linear regression models to indirectly estimate driver's drowsiness level in a virtual-reality-based driving simulator. Results show that it is feasible to quantitatively monitor driver's alertness with concurrent changes in driving performance in a realistic driving simulator
Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses

Near-atomic resolution structure of species-D adenovirus 26 (HAdV-D26) reveals structural conservation among human adenoviruses. Human adenoviruses (HAdVs) cause acute respiratory, ocular, and gastroenteric diseases and are also frequently used as gene and vaccine delivery vectors. Unlike the archetype human adenovirus C5 (HAdV-C5), human adenovirus D26 (HAdV-D26) belongs to species-D HAdVs, which target different cellular receptors, and is differentially recognized by immune surveillance mechanisms. HAdV-D26 is being championed as a lower seroprevalent vaccine and oncolytic vector in preclinical and human clinical studies. To understand the molecular basis for their distinct biological properties and independently validate the structures of minor proteins, we determined the first structure of species-D HAdV at 3.7 Å resolution by cryo-electron microscopy. All the hexon hypervariable regions (HVRs), including HVR1, have been identified and exhibit a distinct organization compared to those of HAdV-C5. Despite the differences in the arrangement of helices in the coiled-coil structures, protein IX molecules form a continuous hexagonal network on the capsid exterior. In addition to the structurally conserved region (3 to 300) of IIIa, we identified an extra helical domain comprising residues 314 to 390 that further stabilizes the vertex region. Multiple (two to three) copies of the cleaved amino-terminal fragment of protein VI (pVIn) are observed in each hexon cavity, suggesting that there could be ≥480 copies of VI present in HAdV-D26. In addition, a localized asymmetric reconstruction of the vertex region provides new details of the three-pronged “claw hold” of the trimeric fiber and its interactions with the penton base. These observations resolve the previous conflicting assignments of the minor proteins and suggest the likely conservation of their organization across different HAdVs.
Cardioprotection by resveratrol : A human clinical trial in patients with stable coronary artery disease

Several beneficial effects of resveratrol (RES), a natural antioxidant present in red wine have already been described. The aim of our study was to investigate if RES had a clinically measurable cardioprotective effect in patients after myocardial infarction. In this double-blind, placebo controlled trial 40 post-infarction Caucasian patients were randomized into two groups. One group received 10 mg RES capsule daily for 3 months. Systolic and diastolic left ventricular function, flow-mediated vasodilation (FMD), several laboratory and hemorheological parameters were measured before and after the treatment. Left ventricular ejection fraction showed an increasing tendency (ns) by RES treatment. However, left ventricular diastolic function was improved significantly (p < 0.01) by RES. A significant improvement in endothelial function measured by FMD was also observed (p < 0.05). Low-density lipoprotein (LDL) level significantly decreased (p < 0.05) in the RES treated group. Red blood cell deformability decreased and platelet aggregation increased significantly in the placebo group (p < 0.05), while resveratrol treatment has prevented these unfavourable changes. Concerning other measured parameters no significant changes were observed neither in placebo nor in RES group. Our results show that resveratrol improved left ventricle diastolic function, endothelial function, lowered LDL-cholesterol level and protected against unfavourable hemorheological changes measured in patients with coronary artery disease (CAD).
Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture

ABSTRACT The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutantdLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+strains (G.-C. Perng, C. Jones, J. Ciacci-Zarella, M. Stone, G. Henderson, A. Yokht, S. M. Slanina, F. M. Hoffman, H. Ghiasi, A. B. Nesburn, and C. S. Wechsler, Science 287:1500–1503, 2000). The same study also demonstrated that a plasmid expressing LAT nucleotides 301 to 2659 enhanced cell survival of transfected cells after induction of apoptosis. Consequently, we hypothesized that LAT enhances spontaneous reactivation in part, because it promotes survival of infected neurons. Here we report on the ability of plasmids expressing different portions of the 5′ end of LAT to promote cell survival after induction of apoptosis. A plasmid expressing the first 1.5 kb of LAT (LAT nucleotides 1 to 1499) promoted cell survival in neuro-2A (mouse neuronal) and CV-1 (monkey fibroblast) cells. A plasmid expressing just the first 811 nucleotides of LAT promoted cell survival less efficiently. Plasmids expressing the first 661 nucleotides or less of LAT did not promote cell survival. We previously showed that a mutant expressing just the first 1.5 kb of LAT has wild-type spontaneous reactivation in rabbits, and a mutant expressing just the first 811 nucleotides of LAT has a reactivation frequency higher than that of dLAT2903 but lower than that of wild-type virus. In addition, mutants reported here for the first time, expressing just the first 661 or 76 nucleotides of LAT, had spontaneous reactivation indistinguishable from that of the LAT null mutantdLAT2903. In summary, these studies provide evidence that there is a functional relationship between the ability of LAT to promote cell survival and its ability to enhance spontaneous reactivation.
Current Challenges and Approaches for Resource Demand Estimation in the Cloud

The increasing popularity of Cloud computing, especially for high performance computing (HPC) applications offers a huge potential for optimizing the consumption of compute resources. Since hybrid Cloud platforms in particular offer the best balance between data security, performance, business agility and mobile support, they are used more and more frequently. In this work, we highlight the most important challenges that arise for resource demand estimation systems, especially in public and hybrid Cloud environments. We present existing approaches, separated in load-balancing - or single resource type systems - and Cloud or virtual machine (VM) type selection - or multiple resource type systems. The approaches are analyzed in different aspects including their potential to overcome the presented challenges and their applicability in different Cloud environments. Our research reveals that not all of the issues have been resolved yet but the means to achieve that are available. We conclude our work with useful suggestions that can help to overcome the remaining challenges.
Iron supplementation improves energetic efficiency in iron-depleted female rowers.

PURPOSE Studies in both animals and humans show a relationship between iron depletion without anemia (IDNA) and physical performance. Compared with their sedentary counterparts, female endurance athletes are at greater risk of IDNA, and consequences relevant to endurance athletes include reduced work capacity and energetic efficiency (EF). We conducted a randomized placebo-controlled trial to investigate the effects of iron (Fe) supplementation on Fe status and performance in nonanemic female rowers during training. METHODS At the beginning of a training season, 40 rowers were randomized to receive either 100 mg·d FeSO4 (n = 21) or placebo (n = 19) using a double-blind design. Thirty-one (n = 15 Fe, 16 placebo) completed the 6-wk trial. Fe status (hemoglobin, serum ferritin, soluble transferrin receptor), body composition, and laboratory tests of physical performance (4-km time trial, V˙O2peak, energetic EF, and blood lactate) were assessed at baseline and after training. RESULTS Rowers in both groups increased their fat-free mass (P < 0.001) and V˙O2peak (P < 0.001) after training. Multiple regression analyses revealed improvements in Fe stores (serum ferritin) in the Fe treatment group after controlling for baseline Fe stores (P = 0.07). Rowers in the Fe group had slower lactate response during the first half of the time trial and after 5 min of recovery (P = 0.05) and showed greater improvements in energy expenditure (P = 0.01 for group-by time) and energetic EF compared with placebo (P = 0.03 for group-by time). CONCLUSIONS Female rowers with depleted Fe stores who consumed supplemental Fe during training improved their Fe status and energetic EF during endurance exercise. These results are important for endurance athletes whose dietary patterns and physical training increase their risk of IDNA and suggest that Fe supplementation may maximize the benefits of endurance training.
Improved Statistical Measures to Assess Natural Language Parser Performance across Domains

We examine the performance of three dependency parsing systems, in particular, their performance variation across Wikipedia domains. We assess the performance variation of (i) Alpino, a deep grammar-based system coupled with a statistical disambiguation versus (ii) MST and Malt, two purely data-driven statistical dependency parsing systems. The question is how the performance of each parser correlates with simple statistical measures of the text (e.g. sentence length, unknown word rate, etc.). This would give us an idea of how sensitive the different systems are to domain shifts, i.e. which system is more in need for domain adaptation techniques. To this end, we extend the statistical measures used by Zhang and Wang (2009) for English and evaluate the systems on several Wikipedia domains by focusing on a freer word-order language, Dutch. The results confirm the general findings of Zhang and Wang (2009), i.e. different parsing systems have different sensitivity against various statistical measure of the text, where the highest correlation to parsing accuracy was found for the measure we added, sentence perplexity.
Gender's Role in Responses to Infertility

Infertility is a major life stressor that affects approximately 10% of U.S. married couples. Infertile women and men have reported experiencing depression, helplessness, and marital strain. Given U.S. society's emphasis on women's role as mothers, it has been suggested that women's lives are more disrupted by infertility than those of men. This hypothesis was supported in a survey of 185 infertile couples and 90 presumed fertile couples. Infertile wives, as compared to their husbands, perceived their fertility problem as more stressful, felt more responsible for and in control of their infertility, and engaged in more problem-focused coping. Infertile husbands experienced more home life stress and lower home life performance than did their wives. These differences were not found for presumed fertile couples. Both infertile and presumed fertile wives experienced more depression, more sexual dissatisfaction, and lower self-esteem than did their husbands. Theoretical and counseling implications of these findings are discussed.
Distributed Recognition of Reference Nodes for Wireless Sensor Network Localization

All known localization techniques for wireless sensor and ad-hoc networks require certain set of reference nodes being used for position estimation. The anchor-free techniques in contrast to anchor-based do not require refer- ence nodes called anchors to be placed in the network area before localization operation itself, but they can establish own reference coordinate system to be used for the relative position estimation. We observed that contemporary anchor- free localization algorithms achieve low localization error, but dissipate significant energy reserves during the recog- nition of reference nodes used for the position estimation. Therefore, we have proposed an optimized anchor-free lo- calization algorithm referred to as BRL (Boundary Recog- nition aided Localization), which achieves a low localiza- tion error and mainly reduces the communication cost of the reference nodes recognition phase. The proposed BRL al- gorithm was investigated throughout the extensive simula- tions on the database of networks with the different number of nodes and densities and was compared in terms of commu- nication cost and localization error with the known related algorithms such as AFL and CRP. Through the extensive sim- ulations we have observed network conditions where novel BRL algorithm excels in comparison with the state of art.
The ATPase Cross-bridge Cycle of the Kar3 Motor Domain

Kar3 is a minus-end directed microtubule motor involved in meiosis and mitosis in Saccharomyces cerevisae. Unlike Drosophila Ncd, the other well characterized minus-end directed motor that is a homodimer, Kar3 is a heterodimer with a single motor domain and either the associated polypeptides Cik1 or Vik1. Our mechanistic studies with Ncd showed that both motor domains were required for ATP-dependent motor domain detachment from the microtubule. We have initiated a series of experiments to compare the mechanistic requirements for Kar3 motility in direct comparison to Ncd. The results presented here show that the single motor domain of Kar3 (Met383-Lys729) exhibits characteristics similar to monomeric Ncd. The microtubule-activated steady-state ATPase cycle of Kar3 (k cat = 0.5 s−1) is limited by ADP release (0.4 s−1). Like monomeric Ncd, Kar3 does not readily detach from the microtubule with the addition of MgATP. These results show that the single motor domain of Kar3 is not sufficient for ATP-dependent microtubule dissociation, suggesting that structural elements outside of the catalytic core are required for the cyclic interactions with the microtubule for force generation.
An invitation to social psychology: expressing and censoring the self. Miller, D. T. (Ed.). 2006, Thomson Wadsworth, ISBN 0534592058

Organized around the theme of self-censorship -the disconnect between what people privately think or feel and how they act publicly -this brief seven-chapter text introduces students to social psychology by focusing on the field's most interesting studies and real-world applications. An INVITATION TO SOCIAL PSYCHOLOGY contains high-interest studies that will engage students as they convey how social psychologists think about social life. Dale Miller shows that the common and extreme forms of social behavior are more alike than unlike. With an emphasis on social interaction in everyday situations, he makes connections to students' lives as if to say "we've all been in this situation. " AN INVITATION TO SOCIAL PSYCHOLOGY covers fewer studies but in considerably more detail than a traditional introductory text. It includes textured descriptions, so students come away with a deeper understanding of the core methodologies used by social psychologists to understand the world from a social psychological perspective. Miller achieves the balance of crafting a social psychology text that is valuable to instructors, while at the same time interesting and fun for students. Miller's text can be used as either a core or supplemental text in an introductory or advanced social psychology course.
Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer.

BACKGROUND Primary tumor levels of serine proteases of the kallikrein-related peptidases (KLK) family as well as urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 impact disease course in ovarian cancer. The changes in levels of these factors from primary tumor to omentum metastasis ('level differentials') could thus be associated with metastastic processes. PATIENTS AND METHODS Protein levels of seven tissue KLK (KLK5-8, 10, 11, 13), uPA, and PAI-1 were determined in extracts of primary tumor tissue and corresponding omentum metastasis of 54 ovarian cancer patients. RESULTS Higher level differentials of KLK5-8, 10-11, and uPA were associated with residual tumor >10 mm. Residual tumor and larger level differentials of KLK5-7, 10, and uPA were associated with disease progression in the whole cohort. Remarkably, level differentials of KLK5-8 and 10-11 strongly impacted disease progression even in patients with residual tumor mass ≤10 mm; hence, the observed impact of level differentials in KLK5-7 and 10 on disease progression was not simply attributable to their association with surgical success. CONCLUSION Since they impact both surgical outcome and survival in advanced ovarian cancer, measurement of level differentials could support clinical decisions on surgical and systemic therapy or help in patient selection for novel targeted therapies.
Corneal Confocal Microscopy Is Emerging as a Powerful Diagnostic Tool for Assessing Systemic Neurologic Disease.

The diagnosis and monitoring of systemic neurologic disease represents an ongoing and significant challenge. However, 21st century advances in ophthalmic imaging are opening up new opportunities for direct, instantaneous, in vivo, cost-effective, reiterative, noninvasive imaging of nerve morphology. Optical coherence tomography allows direct optical imaging of neural layers of the retina, and thinning of these layers has been shown to correlate with both ophthalmic and systemic diseases that involve nerve pathology. A technique that has been to some extent overshadowed by optical coherence tomography, in view of its perceived more limited utility in ophthalmic imaging, is corneal confocal microscopy. Proof of concept for assessing neurologic disease emerged from extensive research on the capability of this technique to diagnose, stage severity, monitor progression, and predict future incidence of diabetic peripheral neuropathy. Indeed, this technique is rapidly supplanting electrodiagnosis and skin punch biopsy as the new ‘‘gold standard’’ for assessing small fiber neuropathy in diabetes. The realization that ophthalmic nerve assessment can be used to assess systemic neurologic deficits has led researchers to explore the application of this technique to other disorders, such as Parkinson’s disease and multiple sclerosis. The study of Petropoulos et al. confirms and consolidates previous research by demonstrating how corneal confocal microscopy and optical coherence tomography are capable of detecting significant corneal and retinal nerve degeneration in patients with multiple sclerosis, which relates to the severity of neurologic deficits in patients exhibiting mild manifestations of this disease. Translation of ongoing research into wide-field imaging and automated image analysis holds promise for the deployment of this technology into routine clinical settings. More recent corneal confocal microscopy studies of the rate of corneal nerve migration, and how this parameter is slowed in the presence of diabetic peripheral neuropathy, may further extend the diagnostic capability of this approach.
Secundum atrial septal defect: routine surgical treatment is not of proven benefit.

Secundum atrial septal defect accounts for 10% of congenital heart disease4 at birth and for 30-40% of cases seen in adults.5 Approximately 300-400 patients undergo surgical closure of atrial septal defect in the United Kingdom each year. Reports of the natural history of atrial septal defect and of the indications for and results of surgery imply that patients become increasingly symptomatic with advancing years, that surgical closure in childhood prevents this happening and in adult life reverses the deterioration. It is therefore widely but not universally6 advocated that atrial septal defects with a pulmonary to systemic flow ratio > 1 5:1 should be closed.5 The evidence
Less is More? Investigating the Role of Examples in Security Studies using Analogical Transfer

Information system developers and administrators often over-look critical security requirements and best practices. This may be due to lack of tools and techniques that allow practitioners to tailor security knowledge to their particular context. In order to explore the impact of new security methods, we must improve our ability to study the impact of security tools and methods on software and system development. In this paper, we present early ﬁndings of an experiment to assess the extent to which the number and type of examples used in security training stimuli can impact security problem solving. To motivate this research, we formulate hypotheses from analogical transfer theory in psychology. The independent variables include number of problem surfaces and schemas, and the dependent variable is the answer accuracy. Our study results do not show a statistically signiﬁcant difference in performance when the number and types of examples are varied. We discuss the limitations, threats to validity and opportunities for future studies in this area.