Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term outcome of early percutaneous coronary intervention in diabetic patients with acute coronary syndrome: insights from the BASE ACS trial

Abstract Background: The BASE ACS trial demonstrated an outcome of titanium-nitride-oxide-coated bioactive stents (BAS) that was non-inferior to everolimus-eluting stents (EES) in patients with acute coronary syndrome (ACS). We performed a post-hoc analysis of diabetic versus non-diabetic patients from the trial. Methods: We randomised 827 patients (1:1) with ACS to receive either BAS or EES. The primary endpoint was major adverse cardiac events (MACE): a composite of cardiac death, non-fatal myocardial infarction (MI) or ischaemia-driven target lesion revascularisation (TLR). Follow-up was planned yearly through 7 years. Results: Of 827 patients, 140 (16.9%) were diabetic; of these, 36 (25.7%) were insulin-treated. Mean follow-up duration was 4.2 ± 1.9 years. MACE was more frequent in diabetics versus non-diabetics (23.6% versus 13.7%, respectively, p = 0.003), mainly driven by more frequent cardiac death (7.9% versus 2.2%, respectively, p = 0.002). The rates of non-fatal MI, ischaemia-driven TLR were comparable (p > 0.05 for all). In diabetic patients, MACE was comparable between the two stent arms (18.5% versus 28.0%, for BAS versus EES, respectively, p = 0.18). Conclusions: Diabetic patients treated with early percutaneous coronary intervention for ACS had worse long-term outcome, compared with non-diabetics, mainly driven by more frequent cardiac death. The long-term outcome of BAS was comparable to EES in diabetics. Key Messages Diabetic patients presenting with acute coronary syndrome who were treated with early percutaneous coronary intervention had worse long-term clinical outcome, compared with non-diabetics, mainly driven by a high incidence of cardiac death. Age independently predicted both major adverse cardiac events and cardiac death in diabetic patients. The long-term clinical outcome of titanium-nitride-oxide-coated bioactive stents was comparable to that of everolimus-eluting stents in the diabetic, as well as in the non-diabetic subgroup.
Acute and 13-week subchronic toxicological evaluations of turanose in mice

BACKGROUND/OBJECTIVES Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice. MATERIALS AND METHODS For the acute oral toxicity study, turanose was administered as a single oral dose [10 g/kg body weight (b.w.)]. In the subchronic toxicity study, ICR mice were administered 0, 1.75, 3.5, and 7 g/kg b.w. doses of turanose daily for 13 weeks. RESULTS No signs of acute toxicity, including abnormal behavior, adverse effect, or mortality, were observed over the 14-day study period. In addition, no changes in body weight or food consumption were observed and the median lethal dose (LD50) for oral intake of turanose was determined to be greater than 10 g/kg b.w. General clinical behavior, changes in body weight and food consumption, absolute and relative organ weights, and mortality were not affected in any of the treatment group for 13 weeks. These doses also did not affect the macroscopic pathology, histology, hematology, and blood biochemical analysis of the mice examined. CONCLUSION No toxicity was observed in the acute and 13-week subchronic oral toxicology studies that were conducted with ICR mice. Furthermore, the no-observed-adverse-effect level is greater than 7 g/kg/day for both male and female ICR mice.
[Community structure and diversity of culturable moderate halophilic bacteria isolated from Qrhan salt lake on Qinghai-Tibet Plateau].

Objective I studied the community structure and diversity of culturable moderate halophilic bacteria isolated from Qrhan Salt Lake. Methods I isolated and cultured the moderate halophilic bacteria on different selective media. After the 16S rRNA gene sequences was amplified and measured, I constructed the phylogenic tree, analyzed the community structure and calculated the diversity indexes according to the 16S rRNA gene information. Results A total of 421 moderate halophilic bacteria were isolated from water and mud samples in Qrhan Salt Lake. The 16S rRNA gene information showed that 4 potential novel species belonged to the family Bacillaceae. Eighty-three model strains belonged to 3 phylurms 6 families 16 genus. Among them, Bacillus sp. , Oceanobacillus sp. and Halomonas sp. were dominant species. Diversity analysis showed that the diversity of strains isolated from water sample was higher than that from mud sample, but the dominance degree of strains isolated from mud sample was higher than that from water sample. Conclusion The genetic diversity of moderate halophilic bacteria isolated from Qrhan Salt Lake was abundant. Also, there were dominant and novel species of culturable moderate halophilic bacteria in this lake.
Bone Cement Implantation Syndrome in Cemented Hip Arthroplasty: Hypothetization of a New Therapeutic Approach and Proposition of a Treatment Algorithm

Purpose: Management of bone cement implantation syndrome (BCIS) during or immediately after hip arthroplasty (HA) is difficult and often leads to mortality. We have reviewed the medical records of patients submitted to HA at our institution and propose a standard operating procedure (SOP) for the event of cardiogenic shock. Methods: SOP was based on the analysis of the medical records of patients who had been submitted to cemented (n = 250) or uncemented (n = 408) HA, three of whom died because of BCIS, and on the individual experiences of the surgical team, taking into consideration the pathophysiology of acute right ventricular failure. Results: The proposed SOP involves the use of extracorporeal membrane oxygenation (ECMO) as a complementary therapy to mechanical ventilation with the purpose of improving patient outcome and reducing the risk of death. Inclusion and exclusion criteria, along with recommendations for the use of ECMO, are presented. Conclusion: Although our hypothesis has yet to be fully validated, the proposed a SOP has been implemented in our hospital. Because of the rarity of BCIS, we hope that the SOP will be effectuated in other institutions to ascertain the effectiveness of ECMO in the treatment of BCIS.
Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis

To uncover the genes associated with the development of esophageal squamous cell carcinoma (ESCC), an ESCC microarray dataset was used to identify genes differentially expressed between ESCC and normal control tissues. The dataset GSE17351 was downloaded from the Gene Expression Omnibus, containing 5 tumor esophageal mucosa samples and 5 adjacent normal esophageal mucosa samples from 5 male patients with ESCC. The differentially expressed genes (DEGs) were identified using the Linear Models for Microarray Data R package. Then, a co-expression network was constructed using the Weighted Correlation Network Analysis (WGCNA) package, and co-expression network modules were obtained with a hierarchical clustering algorithm. Additionally, functional enrichment analyses for DEGs in the top 2 modules with the highest significance were respectively conducted using the WGCNA package and the cluster Profiler package. In total, 487 upregulated and 468 downregulated DEGs were identified. A total of 24 modules were obtained from the co-expression network, and the top 2 modules with the highest significance, designated as ‘blue4’ and ‘magenta’, were further analyzed. In the module blue4, DEGs were significantly enriched in a number of Gene Ontology terms, including ‘spindle organization’ [e.g., ubiquitin conjugating enzyme E2 C (UBE2C) and SAC3 domain containing 1] and ‘cell cycle process’ [e.g., UBE2C, minichromosome maintenance complex component 6 (MCM6) and cell division cycle 20 (CDC20)]. Furthermore, a number of DEGs (e.g., UBE2C, CDC20 and MCM6) were enriched in the ‘cell cycle’ and ‘ubiquitin mediated proteolysis’ pathways. In the module ‘magenta’, a number of DEGs [e.g., transferrin receptor (TFRC) and TEA domain transcription factor 4 (TEAD4)] were enriched in the primary metabolic process and intracellular membrane-bounded organelle. Additionally, 308 upregulated genes and 215 downregulated genes were differentially expressed in the same pattern in another dataset, GSE20347, including UBE2C, CDC20, MCM6, TFRC, TEAD4, protein phosphatase 1 regulatory subunit 3C and MAL, T-cell differentiation protein. These DEGs may function in the development of ESCC.
sockets Application Arbiter Library Core Ar shared memory Arachne Runtime Core Policy 1 Application Arbiter Library Arachne Runtime Core Policy 2 Application Arbiter Library Custom Thread

Arachne is a new user-level implementation of threads that provides both low latency and high throughput for applications with extremely short-lived threads (only a few microseconds). Arachne is core-aware: each application determines how many cores it needs, based on its load; it always know exactly which cores it has been allocated, and it controls the placement of its threads on those cores. A central core arbiter allocates cores between applications. Adding Arachne to memcached improved SLO-compliant throughput by 37%, reduced tail latency by more than 10x, and allowed memcached to coexist with background applications with almost no performance impact. Adding Arachne to the RAMCloud storage system increased its write throughput by more than 2.5x. The Arachne threading library is optimized to minimize cache misses; it can initiate a new user thread on a different core (with load balancing) in 220 ns. Arachne is implemented entirely at user level on Linux; no kernel modifications are needed.
Pathogen-Responsive MPK3 and MPK6 Reprogram the Biosynthesis of Indole Glucosinolates and Their Derivatives in Arabidopsis Immunity[OPEN]

Arabidopsis MPK3/MPK6 and the downstream ERF6 substrate promote the biosynthesis of indole glucosinolates and their derivatives in plant immunity. Antimicrobial compounds have critical roles in plant immunity; for example, Arabidopsis thaliana and other crucifers deploy phytoalexins and glucosinolate derivatives in defense against pathogens. The pathogen-responsive MITOGEN-ACTIVATED PROTEIN KINASE3 (MPK3) and MPK6 have essential functions in the induction of camalexin, the major phytoalexin in Arabidopsis. In search of cyanide, a coproduct of ethylene and camalexin biosynthesis, we found that MPK3 and MPK6 also affect the accumulation of extracellular thiocyanate ion derived from the indole glucosinolate (IGS) pathway. Botrytis cinerea infection activates MPK3/MPK6, which promote indole-3-yl-methylglucosinolate (I3G) biosynthesis and its conversion to 4-methoxyindole-3-yl-methylglucosinolate (4MI3G). Gain- and loss-of-function analyses demonstrated that MPK3/MPK6 regulate the expression of MYB51 and MYB122, two key regulators of IGS biosynthesis, as well as CYP81F2 and IGMT1/IGMT2, which encode enzymes in the conversion of I3G to 4MI3G, through ETHYLENE RESPONSE FACTOR6 (ERF6), a substrate of MPK3/MPK6. Under the action of PENETRATION2 (PEN2), an atypical myrosinase, and PEN3, an ATP binding cassette transporter, 4MI3G is converted to extracellular unstable antimicrobial compounds, possibly isothiocyanates that can react with nucleophiles and release the stable thiocyanate ion. Recent studies demonstrated the importance of PEN2/PEN3-dependent IGS derivatives in plant immunity. Here, we report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Effect of Moderately Increased Intrapelvic on Renal Tissue Pressure and Vasopressin in Rabbits Pressure Release

Electrical stimulation of afferent renal nerves and activation of intrarenal receptors increases plasma vasopressin concentration, but the role of afferent renal nerves in the control of vasopressin secretion is not clear. Recently, we reported that activation of renal mechanoreceptors stimulates the release of vasopressin. However, Intrapelvic pressure was increased to 50 mmHg, and this increase is above the normal physiological range. Therefore, in the present study, we investigated the effect of moderately increased intrapelvic pressure on plasma vasopressin concentration in anesthetized rabbits. First, we measured renal tissue pressure while Intrapelvic pressure was increased stepwise in 10-mmHg increments. Basal renal tissue pressure was 17 ± 2 mmHg. Renal tissue pressure increased only when Intrapelvic pressure was higher than the basal tissue pressure of each animal. Usually, increases in intrapelvic pressure less than 20 mmHg did not increase renal tissue pressure. This finding suggests that only increases in Intrapelvic pressure more than 20 mmHg can activate renal mechanoreceptors. Based on this finding, the effects of moderate increases in intrapelvic pressure (15 and 30 mmHg) were studied. With a 15-mmHg increase in intrapelvic pressure, plasma vasopressin concentration did not change significantly. However, when Intrapelvic pressure was increased to 30 mmHg, plasma vasopressin concentration increased from 5.6±1.4 to 9.5±2.8 pg/ml at 5 min (p<0.05) and to 8.8±2.0 pg/ml at 10 mm (p< 0.05). Plasma renin activity and mean arterial pressure also increased when intrapelvic pressure was increased to 30 mmHg. We conclude that moderate increases in intrapelvic pressure stimulate vasopressin secretion. This provides further evidence that the kidneys participate in the physiological control of vasopressin release by way of afferent renal nerves. (Hypertens Res 1995; 18: 197-202)
On a Connection between Froot-Stein and the De Finetti Optimal Dividends Models

Costly external capital is one of the frictions that violates the premises of the Modigliani and Miller irrelevance theorems. Froot et. al. developed a three-stage model to explain how costly external capital, along with other frictions, provides an opportunity for risk management to create value. This paper extends their model to analyze risk management (in particular, reinsurance) in the context of a going concern. It relates the extended Froot model to a fifty-year-old stochastic dividend optimization problem, introduced by Bruno de Finetti, which has received growing interest in the recent decade.
Impaired growth and development after sunitinib treatment in a child with locally progressive kidney cancer

Objective: To determine the safety and efficiency of sunitinib for renal cancer treatment in a pediatric patient. Methods: A 12-year-old girl with locally progressive renal cancer was hospitalized on June 27, 2011 because of continuous pain in the lower back and abdomen since 2 days and fever since 1 day after sustaining a trauma. Computed tomography revealed a massive, mixed-density lesion (60 × 70 × 70 mm) in the middle and lower parts of the right kidney and a round, mixed-density, retroperitoneal nodule (10 × 16 mm). Right renal cancer with retroperitoneal lymph node metastasis was considered. The patient underwent radical nephrectomy and regional lymph node dissection, and postoperative treatment with sunitinib (25 mg/day) for 4 weeks followed by a 2-week drugfree interval. Eight such 6-week courses were performed, starting from August 1, 2011. Result: The latest follow-up examination was conducted in October 2014. After the first sunitinib course, the patient developed decrustation in the palms and soles. This symptom did not occur after the second course. Skin rash occurred mostly on the back and neck during the third course, and resolved spontaneously during the drug-free interval. It did not recur during subsequent courses. Fatigue, weakness, and intolerance to cold occurred since the first course. The results of routine blood, liver-function, kidney-function, and thyroid-function tests after each course were normal. Conclusion: Sunitinib was safe and effective for renal cancer treatment in our patient, and caused few adverse reactions. However, the drug might impair growth and development in children.
Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins

Adverse environments occurring during kidney development may produce long-term programming effects, namely renal programming, to create increased vulnerability to the development of later-life hypertension and kidney disease. Conversely, reprogramming is a strategy aimed at reversing the programming processes in early life, even before the onset of clinical symptoms, which may counter the rising epidemic of hypertension and kidney disease. Hydrogen sulfide (H2S), the third gasotransmitter, plays a key role in blood pressure regulation and renal physiology. This review will first present the role of H2S in the renal system and provide evidence for the links between H2S signaling and the underlying mechanisms of renal programming, including the renin–angiotensin system, oxidative stress, nutrient-sensing signals, sodium transporters, and epigenetic regulation. This will be followed by potential H2S treatment modalities that may serve as reprogramming strategies to prevent hypertension and kidney disease of developmental origins. These H2S treatment modalities include precursors for H2S synthesis, H2S donors, and natural plant-derived compounds. Despite emerging evidence from experimental studies in support of reprogramming strategies targeting the H2S signaling pathway to protect against hypertension and kidney disease of developmental origins, these results need further clinical translation.
Relationship between culture of excellence and organisational performance in Iranian manufacturing companies

High-performing organisations are those which practise exemplary Culture of Excellence (CoE). Global competition dictates that only high-performing organisations will survive in the long term. This study attempts to focus on the relationship between CoE constructs and organisational performance (OP) in the context of Iranian manufacturing sector. Data are gathered via survey, of 222 excellence award-winning companies in Iran. The SPSS and smartPLS were used to test the relationship between CoE factors and OP. The result of correlation analysis proved that all 10 CoE constructs were significantly correlated with OP and there exists a significant relationship between CoE and OP. Strong commitment was the most important factor and the bottom rank was high degree of motivation. According to the results, CoE might be supported as a perfect management system to efficiently upkeep organisational competitiveness. Current results might contribute to the improvement of superior OP through creating a reliable and valid measurement tool for CoE. This current research offers interesting insights for researchers and practitioners in the field of quality management.
Distributed Aggregate Function Estimation by Biphasically Configured Metropolis-Hasting Weight Model

An energy-efficient estimation of an aggregate function can significantly optimize a global event detection or monitoring in wireless sensor networks. This is probably the main reason why an optimization of the complementary consensus algorithms is one of the key challenges of the lifetime extension of the wireless sensor networks on which the attention of many scientists is paid. In this paper, we introduce an optimized weight model for the average consensus algorithm. It is called the Biphasically configured Metropolis-Hasting weight model and is based on a modification of the Metropolis-Hasting weight model by rephrasing the initial configuration into two parts. The first one is the default configuration of the Metropolis-Hasting weight model, while, the other one is based on a recalculation of the weights allocated to the adjacent nodes’ incoming values at the cost of decreasing the value of the weights of the inner states. The whole initial configuration is executed in a fully-distributed manner. In the experimental section, it is proven that our optimized weight model significantly optimizes the Metropolis-Hasting weight model in several aspects and achieves better results compared with other concurrent weight models.
Breed Differences in Domestic Dogs' (Canis familiaris) Comprehension of Human Communicative Signals

Recent research suggests that some human-like social skills evolved in dogs (Canis familiaris) during domestication as an incidental by-product of selection for “tame” forms of behavior. It is still possible, however, that the social skills of certain dog breeds came under direct selection that led to further increases in social problem solving ability. To test this hypothesis, different breeds of domestic dogs were compared for their ability to use various human communicative behaviors to find hidden food. We found that even primitive breeds with little human contact were able to use communicative cues. Further, “working” dogs (shepherds and huskies: thought to be bred intentionally to respond to human cooperative communicative signals) were more skilled at using gestural cues than were non-working breeds (basenji and toy poodles: not thought to have been bred for their cooperative-communicative ability). This difference in performance existed regardless of whether the working breeds were more or less genetically wolf-like. These results suggest that subsequent to initial domesticating selection giving rise to cue-following skills, additional selection on communicative abilities in certain breeds has produced substantive differences in those breeds’ abilities to follow cues.
Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single- or dual-agent preexposure prophylaxis.

BACKGROUND Preexposure prophylaxis (PrEP) with emtricitabine plus tenofovir disoproxil fumarate (FTC/TDF) or TDF alone reduces the risk of human immunodeficiency virus (HIV) acquisition. Understanding the risk of antiretroviral resistance selected by PrEP during breakthrough infections is important because of the risk of treatment failure during subsequent antiretroviral use. METHODS Within the largest randomized trial of FTC/TDF versus TDF as PrEP, plasma samples were tested for HIV with resistance mutations associated with FTC (K65R and M184IV) and TDF (K65R and K70E), using 454 sequencing. RESULTS Of 121 HIV seroconverters, 25 received FTC/TDF, 38 received TDF, and 58 received placebo. Plasma drug levels in 26 individuals indicated PrEP use during or after HIV acquisition, of which 5 had virus with resistance mutations associated with their PrEP regimen. Among those with PrEP drug detected during infection, resistance was more frequent in the FTC/TDF arm (4 of 7 [57%]), compared with the TDF arm (1 of 19 [5.3%]; P = .01), owing to the FTC-associated mutation M184IV. Of these cases, 3 had unrecognized acute infection at PrEP randomization, and 2 were HIV negative at enrollment. CONCLUSIONS These results suggest that resistance selected by PrEP is rare but can occur both with PrEP initiation during acute seronegative HIV infection and in PrEP breakthrough infections and that FTC is associated with a greater frequency of resistance mutations than TDF.