Miracle-dz/UniFAR-FTUs huggingface dataset:
A Power-Efficient Co-designed Out-of-Order Processor

A co-designed processor helps in cutting down both the complexity and power consumption by co-designing certain key performance enablers. In this paper, we propose a FIFO based co-designed out-of-order processor. Multiple FIFOs are added in order to dynamically schedule, in a complexity-effective manner, the micro-ops. We propose a commit logic that is able to commit the program state as a superblock commits atomically. This enables us to get rid of the Reorder Buffer (ROB) entirely. Instead to maintain the correct program state, we propose a four/eight entry Superblock Ordering Buffer (SOB). We also propose the per superblock Register Rename Table (SRRT) that holds the register state pertaining to the superblock. Our proposed processor dissipates 6% less power and obtains 12% speedup for SPECFP, as a result, it consumes less energy. Furthermore, we propose an enhanced steering heuristic and an early release mechanism to increase the performance of a FIFO based out-of-order processor. We obtain performance improvement of nearly 25% and 70% for a four FIFO and for a two FIFO configurations, respectively. We also show that our proposed steering heuristic based processor consumes 10% less energy than the previously proposed steering heuristic.
Multiple model switched repetitive control

A multiple model switched repetitive control (RC) framework is developed for a general class of system and widely used RC update structure. This guarantees stability and robust performance under the assumption that the true plant model belongs to a plant uncertainty set specified by the designer. A comprehensive design procedure for the candidate model set and RC update is presented based on novel application of gap metric analysis to RC, and switching of the corresponding RC schemes is achieved efficiently using a bank of Kalman filters.
Temperature Map Recovery Based on Compressive Sensing for Large-Scale Wireless Sensor Networks

Large-Scale Wireless Sensor Networks are widely applied into monitoring indoor and outdoor special events, such as spectrum estimation and temperature sensing. The way of sensing is used to deploy plenty of sensor nodes in the field. However, after analyzing the data we collected from WSNs, we've found that events happened in the same area has presented clustering stably. Instead of randomly showing up all around, events tend to emerge from some individual points. For that reason, the nodes that distributed indiscriminately certainly have redundancies. And these redundancies will bring unnecessarily energy cost. In consider of that, by combining the compressive sensing and matrix completion theory and analyzing the data, we have found that as long as the data collected from WSNs is close to low-rank matrix criteria, at most 88% of nodes can be cut down and 90% energy will be saved.
Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia

Pulmonary arterioles respond to hypoxia with constriction that raises vascular resistance and pulmonary artery blood pressure. The response is sustained indefinitely by the chronic hypoxia of high‐altitude residence among highlanders of European and Andean descent, but not Tibetans. The objective of this study was to identify the consequences of lifelong hypoxia exposure for the pulmonary vasculature among Amhara high‐altitude natives from Ethiopia.
Interactive Image Search with Attribute-based Guidance and Personalization

Interactive image search, where a user initiates a query with keywords and refines it via feedback, can be enhanced using attributes. To minimize the user’s effort, we propose to let the system guide a user’s attribute-based comparative feedback with “pivot” exemplars that most reduce the system’s uncertainty. Since humans vary in how they perceive the link between a named property and image content and might disagree on an attribute’s presence, we further show how to efficiently learn user-specific attribute models. We demonstrate that attribute adaptation and system-driven feedback allow the user to quickly find his desired target.
Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

Confocal imaging and time-lapsed videomicroscopy were used to study the directionality, motility, rate of cell movement, and morphologies of phosphoinositide 3-kinase γ (PI3K)γ−/− neutrophils undergoing chemotaxis in Zigmond chambers containing N-formyl-Met-Leu-Phe gradients. Most of the PI3Kγ−/− neutrophils failed to translocate up the cheomotactic gradient. A partial reduction in cell motility and abnormal morphologies were also observed. In the wild-type neutrophils, the pleckstrin homology domain-containing protein kinase B (AKT) and F-actin colocalize to the leading edge of polarized neutrophils oriented toward the gradient, which was not observed in PI3Kγ−/− neutrophils. In PI3Kγ−/− neutrophils, AKT staining consistently failed to perfectly overlap with the F-actin. This failure was observed as an F-actin-filled region of 2.3 ± 0.5 μm between AKT and the cell membrane. These data suggest that PI3Kγ regulates neutrophil chemotaxis primarily by controlling the direction of cell migration and the intracellular colocalization of AKT and F-actin to the leading edge.
Scalable and efficient implementation of 3d unstructured meshes computation: a case study on matrix assembly

Exposing massive parallelism on 3D unstructured meshes computation with efficient load balancing and minimal synchronizations is challenging. Current approaches relying on domain decomposition and mesh coloring struggle to scale with the increasing number of cores per nodes, especially with new many-core processors. In this paper, we propose an hybrid approach using domain decomposition to exploit distributed memory parallelism, Divide-and-Conquer, D&C, to exploit shared memory parallelism and improve locality, and mesh coloring at core level to exploit vectors. It illustrates a new trade-off for many-cores between structuredness, memory locality, and vectorization. We evaluate our approach on the finite element matrix assembly of an industrial fluid dynamic code developed by Dassault Aviation. We compare our D&C approach to domain decomposition and to mesh coloring. D&C achieves a high parallel efficiency, a good data locality as well as an improved bandwidth usage. It competes on current nodes with the optimized pure MPI version with a minimum 10% speed-up. D&C shows an impressive 319x strong scaling on 512 cores (32 nodes) with only 2000 vertices per core. Finally, the Intel Xeon Phi version has a performance similar to 10 Intel E5-2665 Xeon Sandy Bridge cores and 95% parallel efficiency on the 60 physical cores. Running on 4 Xeon Phi (240 cores), D&C has 92% efficiency on the physical cores and performance similar to 33 Intel E5-2665 Xeon Sandy Bridge cores.
Solid pseudopapillary tumor of the pancreas: clinical-pathological features and management of 13 cases

Background and aim Solid pseudopapillary tumor (SPT) of the pancreas is a rare pathological condition, representing less than 3% of all exocrine pancreatic tumors. SPT usually occurs in young females, without notable symptoms, with a low malignant potential and excellent prognosis. Method We conducted a retrospective study during the period January 2005 – January 2015. SPT patients admitted in our institution were reviewed by describing demographic data, clinico-pathologic and radiological features, therapeutic management and prognosis records. Results Thirteen patients with SPT were identified (10 females), with a median age of 30 years. The main clinical presentation was abdominal pain (92.3%). The tumor was mostly located in the body or tail of the pancreas (77%), and the mean size was 8.2 cm. Regarding the surgical approach there were 5 distal pancreatectomies with splenectomy, 3 body and tail pancreatectomies, 2 body and tail pancreatectomies with splenectomy, 2 pancreato-duodenectomy, 1 partial enucleation and of all only 2 partial resections. Postoperative hematoxylin- eosin staining and immunohistochemistry confirmed the diagnosis in all cases. None of the patients had lymph nodes metastases. Only one local invasion. There was one case of death due to postoperative complications. Four cases followed adjuvant systemic chemotherapy. The mean follow-up was 18 months, without evidence of recurrence during this period. Conclusion SPT should always be considered in the differential diagnosis in young women with a pancreatic tumor. Complete surgical excision is the treatment of choice, and is usually curative. The decision to administer systemic therapy must be individualized. Malignant behavior and late recurrences mandates long-term follow-up for patients with SPT.
The ParPar System: A Software MPP

1.1 Introduction To place ParPar 1. in context, we must rst review the diierent modes of operation common on clusters. Probably the most common approach is to view the cluster as a Network Of Workstations (NOW). With this approach, each node is owned by a certain individual, and is usually also physically located in his work area. The owner uses his workstation for administrative work, such as e-mail, and also for processing, e.g. text processing or engineering applications. But such work typically consumes only a fraction of the workstation's resources. The remaining resources are therefore available for general use by others, who need more resources than their local workstations can provide. Examples of projects based on this approach are the Berkeley NOW, Condor, and MOSIX 3]. At the other extreme are clusters dedicated to a single user at a time, with the explicit goal of executing parallel programs. The motivation is to provide resources for the solution of very demanding problems, and use them as eeciently as possible. Clusters, due to their use of commodity components, are cheap enough to make this possible. The best know system of this type is the Beowulf project. ParPar is related to this approach, but attempts to provide an inexpensive approximation of 1 \Parpar" means \butterry" in Hebrew, which is irrelevant; the name was chosen for its sound, because \par" is short for \parallel", and because two is better than one.
Chemical Interference of Pathogen-associated Molecular Pattern-triggered Immune Responses in Arabidopsis Reveals a Potential Role for Fatty-acid Synthase Type II Complex-derived Lipid Signals*

We describe an experimental setup using submerged cultures of Arabidopsis seedlings in 96-well microtiter plates that permits chemical intervention of rapid elicitor-mediated immune responses. Screening of a chemical library comprising 120 small molecules with known biological activities revealed four compounds reducing cellulysin- or flg22-activated gene expression of the early pathogen-associated molecular patterns (PAMP)-responsive ATL2 gene. One chemical, oxytriazine, was found to induce ATL2 gene expression in the absence of PAMP. By monitoring additional flg22-triggered immediate early plant responses, we present evidence that two compounds, triclosan and fluazinam, interfere with the accumulation of reactive oxygen species and internalization of the activated plasma membrane resident FLS2 immune receptor. Using triclosan structure types and enzyme activity inhibition assays, Arabidopsis MOD1 enoyl-acyl carrier protein reductase, a subunit of the fatty-acid synthase type II (FAS II) complex, was identified as a likely cellular target of triclosan. Inhibition of all tested elicitor-triggered early immune responses by triclosan indicates a potential role for signaling lipids in flg22-triggered immunity. Chemical profiling of eca mutants, each showing deregulated ATL2 gene expression, with the identified compounds revealed mutantspecific response patterns and allowed us to deduce tentative action sites of ECA genes relative to the compound targets.
Genetic Variants in CCNB1 Associated With Differential Gene Transcription and Risk of Coronary In-Stent Restenosis

Background—The development of diagnostic tools to assess restenosis risk after stent deployment may enable the intervention to be tailored to the individual patient, for example, by targeting the use of drug-eluting stent to high-risk patients, with the goal of improving safety and reducing costs. The CCNB1 gene (encoding cyclin B1) positively regulates cell proliferation, a key component of in-stent restenosis. Therefore, we hypothesized that single-nucleotide polymorphisms in CCNB1 may serve as useful tools in risk stratification for in-stent restenosis. Methods and Results—We identified 3 single-nucleotide polymorphisms in CCNB1 associated with increased restenosis risk in a cohort of 284 patients undergoing coronary angioplasty and stent placement (rs350099: TT versus CC+TC; odds ratio [OR], 1.82; 95% confidence interval [CI], 1.09–3.03; P=0.023; rs350104: CC versus CT+TT; OR, 1.82; 95% CI, 1.02–3.26; P=0.040; and rs164390: GG versus GT+TT; OR, 2.27; 95% CI, 1.33–3.85; P=0.002). These findings were replicated in another cohort study of 715 patients (rs350099: TT versus CC+TC; OR, 1.88; 95% CI, 0.92–3.81; P=0.080; rs350104: CC versus CT+TT; OR, 2.23; 95% CI, 1.18–4.25; P=0.016; and rs164390: GG versus GT+TT; OR, 1.87; 95% CI, 1.03–3.47; P=0.040). Moreover, the haplotype containing all 3 risk alleles is associated with higher CCNB1 mRNA expression in circulating lymphocytes and increased in-stent restenosis risk (OR, 1.43; 95% CI, 1.00–1.823; P=0.039). The risk variants of rs350099, rs350104, and rs164390 are associated with increased reporter gene expression through binding of transcription factors nuclear factor-Y, activator protein 1, and specificity protein 1, respectively. Conclusions—Allele-dependent transcriptional regulation of CCNB1 associated with rs350099, rs350104, and rs164390 affects the risk of in-stent restenosis. These findings reveal these common genetic variations as attractive diagnostic tools in risk stratification for restenosis.
Mucosal immunity after vaccination with monovalent and trivalent oral poliovirus vaccine in India.

BACKGROUND Persistent wild-poliovirus transmission, particularly in India, has raised questions about the degree of mucosal immunity induced by oral poliovirus vaccine (OPV) in tropical countries. METHODS Excretion of vaccine poliovirus after challenge with OPV was measured in stool samples collected from children identified by the acute flaccid paralysis surveillance program in India during 2005-2007. The effectiveness of trivalent and monovalent OPV against excretion of each poliovirus type was estimated. RESULTS Vaccine poliovirus was isolated from 4994 (5.2%) of 96,641 children with 2 stool samples. The relative odds of excreting challenge poliovirus among children with 5 reported previous doses of trivalent OPV compared with 0 previous doses was 0.24 (95% confidence interval [CI], 0.12-0.45), 0.08 (95% CI, 0.04-0.14), and 0.40 (95% CI, 0.19-0.85) for serotypes 1, 2, and 3, respectively, but the relative odds increased to 0.62 (95% CI, 0.44-0.88), 0.44 (95% CI, 0.20-0.99), and 0.66 (95% CI, 0.41-1.06), respectively, in the northern states of Uttar Pradesh and Bihar. In these 2 states, the relative odds of excretion of serotype 1 was 0.32 (95% CI, 0.26-0.41) after 5 doses of type 1 monovalent OPV. CONCLUSIONS The mucosal immunity induced by OPV in India varies by location, serotype, and vaccine formulation. These findings have implications for global eradication and the potential role played by inactivated vaccine in this setting.
Identification of Dehydroxytrichostatin A as a Novel Up-Regulator of the ATP-Binding Cassette Transporter A1 (ABCA1)

The ATP-binding cassette transporter A1 (ABCA1) mediates the cellular efflux of excess cholesterol and phospholipids to lipid-poor apolipoprotein A-I (apoA-I). ABCA1 plays an important role in high-density lipoprotein (HDL) biogenesis and reverse cholesterol transport. By using a cell-based screening model for the ABCA1 up-regulator and column chromatography, an active compound, 9179B, was isolated. Through analysis of its NMR data, 9179B was identified as dehydroxytrichostatin A. We found that 9179B increased the transcription of ABCA1 in a cell-based reporter assay, with an EC50 value of 2.65 μM. 9179B up-regulated ABCA1 expression at both mRNA and protein levels in HepG2 and RAW264.7 cells. It also up-regulated the expression of scavenger receptor class B type I (SR-BI) as well as the uptake of DiI-HDL in RAW264.7 cells. This compound stimulated ApoA-I-mediated cellular cholesterol efflux from RAW 264.7 cells. We further found that 9179B was a potent histone deacetylase (HDAC) inhibitor with an IC50 value of 0.08 μM. Reporter gene assays showed that the regulation of ABCA1 transcription by 9179B was mainly mediated by the −171/−75 bp promoter region. Together, our results indicate that 9179B is an ABCA1 up-regulator and dehydroxytrichostatin A may be a novel anti-atherogenic compound.
Current mode imager with nonuniformity correction and edge detection

We describe a current mode image plane processor for edge detection with adaptive nonuniformity correction. The correction is implemented at the pixel level using floating gate MOS transistors operating in the sub- threshold region. Edge detection is achieved through the convolution of the pixel array with programmable kernel matrices. Under uniform illumination, nonuniformity correction reduces the number of spurious edges detected, thus improving the quality and dynamic range of the image plane processors. A prototype array of 16 /spl times/ 16 pixels with a pixel size of 44.8 /spl mu/m by 48.3 /spl mu/m and a fill factor of 21.25% has been designed in a commercially available 0.5 /spl mu/m double poly, triple metal CMOS process.
Bacteremic pneumococcal pneumonia: bone marrow release and pulmonary sequestration of neutrophils.

OBJECTIVES Neutrophils have been implicated in the pathogenesis of acute lung injury in bacteremic pneumococcal pneumonia. The characteristics of the population of neutrophils that injure the lung are still not known. This study was designed to compare the bone marrow release and lung sequestration of neutrophils during bacteremic pneumococcal pneumonia with nonbacteremic pneumonia and isolated bacteremia. DESIGN Prospective, controlled, experimental study. SETTING University research laboratory. SUBJECTS Female New Zealand white rabbits (n = 17; weight 2.3 to 2.7 kg). INTERVENTIONS The rabbits were pretreated with intravenous 5'-bromo-2-deoxyuridine (BrdU 100 mg/kg i.v.) to pulse label dividing neutrophils in the bone marrow. Twenty hours after the treatment with BrdU, the rabbits were anesthetized and pneumonia was induced by instilling Streptococcus pneumoniae (1.5 x 10(9) organisms) into the lower lobe of the lung. Four hours after pneumonia, bacteremia was induced by infusing S. pneumoniae (3.0 x 10(9) organisms) into the circulation (pneumonia + bacteremia: n = 6). These animals were compared with those with just pneumonia (n = 5) or bacteremia (n = 6). MEASUREMENTS AND MAIN RESULTS White blood cell, neutrophil, and differential count. BrdU-labeled neutrophils (neutrophilBrdU) were identified using immunohistochemistry. Cells in tissues were examined microscopically, using sequential level stereologic analysis. The pneumonia + bacteremia group developed a leukopenia (7.3 +/- 0.7 to 2.4 +/- 0.2 x 10(9)/L) following the bacteremia that was associated with an increase in circulating band cells and neutrophilBrdU (2.3 +/- 0.8% to 33.5 +/- 2.8%) which were both higher than those in the other groups (p < .005). Bone marrow smears showed accelerated maturation of neutrophils in the pneumonia + bacteremia group (neutrophilBrdU increased from 11.6 +/- 1.0 to 45.3 +/- 2.1%). Morphometric studies of the lung showed increased neutrophil sequestration in the untreated lung tissue of the pneumonia + bacteremia group (16 +/- 0.8 x 10(8)/mL tissue) compared with the pneumonia (6.6 +/- 0.3 x 10(8)/mL tissue) and bacteremia (12 +/- 0.6 x 10(8)/mL tissue) groups (p < .0001). NeutrophilBrdU preferentially sequester in the lungs of all groups but were slow to migrate into the alveolar air spaces (p < .05). CONCLUSIONS During bacteremic pneumococcal pneumonia there is an accelerated maturation of neutrophils in the bone marrow with an enhanced release of neutrophils into the circulation. These newly released neutrophils preferentially sequester in lung microvessels but are slow to migrate into the alveolar air space.
Privacy Gain Based Multi-Iterative k-Anonymization to Protect Respondents Privacy

Huge volume of data from domain specific applications such as medical, financial, telephone, shopping records and individuals are regularly generated. Sharing of these data is proved to be beneficial for data mining application. Since data mining often involves data that contains personally identifiable information and therefore releasing such data may result in privacy breaches. On one hand such data is an important asset to business decision making by analyzing it. On the other hand data privacy concerns may prevent data owners from sharing information for data analysis. In order to share data while preserving privacy, data owner must come up with a solution which achieves the dual goal of privacy preservation as well as accuracy of data mining task mainly clustering and classification. Privacy Preserving Data Publishing (PPDP) is a study of eliminating privacy threats like linkage attack while preserving data utility by anonymizing data set before publishing. Proposed work is an extension to kanonymization where Privacy Gain (PrGain) has been computed for selective anonymization for set of tuples. Classification and clustering characteristics of original data and anonymized data using proposed algorithm have been evaluated in terms of information loss, execution time, and privacy achieved. Algorithm has been processed against standard data sets and analysis shows that values for sensitive attributes are being preserved with minimal information loss.
Examination of employee alignment as a predictor of work engagement

EXAMINATION OF EMPLOYEE ALIGNMENT AS A PREDICTOR OF WORK ENGAGEMENT By Troy Pasion-Caiani Work engagement, which is defined as a positive affective-motivational state of fulfillment in workers, characterized by vigor, dedication, and absorption in a work role, has been shown to produce many benefits for both individuals and organizations. In the present study, employee alignment was introduced as an additional personal resource measuring employees’ attitudes and beliefs toward their organization, their leaders, and the mission, vision, and goals of their organization. Using a sample of 1,510 employees, this study examined perceived organizational support (POS), supportive leader behavior, and employee alignment as predictors of work engagement. Furthermore, this study tested the incremental validity of employee alignment in predicting work engagement above and beyond POS and supportive leader behavior. It was found that POS, supportive leader behavior, and employee alignment all positively predicted work engagement. Additionally, employee alignment was shown to have additive predictive validity above and beyond POS and supportive leader behavior. These findings suggest that if workers believe in their organization’s mission, vision, goals, leaders, and direction of the company, they are more likely to become engaged in their work role above and beyond perceived organizational support and supportive leader behaviors. Organizational strategies to increase work engagement through POS, supportive leader behavior, and employee alignment are suggested.