Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis, in vitro and in silico Studies of Alkylated Paracetamol Derivatives as Potential Antibacterial Agent

In the field of drug development, structural modification of over-the-counter drugs is extensive to combat drug-resistant strains as well as discover new purposes or biological applications. Paracetamol is an example of OTC analgesic drug that is commonly used in the treatment of pain and fever. In this research, paracetamol was modified by introducing various alkyl chains C 𝑛 H 2 𝑛 +1 , where 𝑛 varied from 3 to 14 via Williamson etherification with bromoalkanes to yield 49% – 86% of N -(4-oxy)phenyl)acetamide derivatives 1-10 . Employing the Kirby-Bauer disc diffusion method, the bacteriostatic activity of the series in comparison to the parental compound (paracetamol) and standard drug (ampicillin) showed that compounds 1 ( n = 3), 4 ( n = 6) and 7 ( n = 9) displayed excellent activity against Escherichia coli with an inhibition zone of 8.1 ± 0.4 mm, 8.3 ± 0.4 mm and 7.9 ± 0.5 mm, respectively, while the paracetamol and ampicillin inhibition zones are 8.0 ± 0.0 mm and 16.0 ± 0.0 mm, respectively. Interestingly, compounds 7 ( n = 9) and 10 ( n = 14) exhibited excellent activity towards Staphylococcus aureus with an inhibition zone of 8.2 ± 0.4 mm and 12.5 ± 0.5 mm, respectively, outperforming paracetamol (6.0 ± 0.0 mm) and ampicillin (11.0 ± 0.0 mm). The in vitro findings were in line with the molecular docking investigation conducted using AutoDock Vina software towards the active site of DNA gyrase enzymes, revealing the structure-activity relationship of the series. Besides, the synthesised compounds 1-10 complied with the drug-likeness analysis and ADME pharmacokinetics profile. The results of this study are significant in delivering new prospects of the potential antibacterial drugs obtained through derivatisation of the known drug, paracetamol. While these initial results are promising, further toxicity and in vivo analyses are necessary to ensure the efficacy and safety of the newly developed drug in living organisms, providing a clearer understanding of its potential as an antibacterial medicine.
Development of a personal multi-pollutant exposure sampler for particulate matter and criteria gases

A novel personal sampler is reported which allows simultaneous measurement of PM 2.5 and PM 10 , ozone, nitrogen dioxide, and sulfur dioxide. This methode combines previously used samplers for personal mass measurement with passive samplers for criteria gases and uses a single pump. Preliminary results are reported for laboratory chamber tests and field comparisons with reference methods for both mass and criteria gases. These results demonstrate the suitability of this sampler for exposure assessment studies.
Achievement Motivation among Students in Indonesia: What is the Role of Teacher-Student Relations, Peer Relations and Moderation of Collectivist Culture?

Although there is much research related to students' achievement motivation, there is still very little research involving social relations at schools and the role of culture in these studies. This research analyses the relationship between teacher-student relations, peer relations, and achievement motivation, as well as whether collectivist culture moderates the relationship between teacher-student and peer relations on achievement motivation. Data was collected using a questionnaire adapted from the Student Teacher Relationship Scale (STRS), the Quality of Relationships Inventory (QRI) Scale, the Individualism-Collectivism Scale (ICS), and an achievement motivation scale. Data analysis used multiple regression analysis and the F. Hayes moderation test. An unexpected finding from this research is that the collectivist culture does not significantly moderate the relationship between teacher-student relations and achievement motivation; the collectivist culture does not significantly moderate the relationship between peer relations and achievement motivation, even though collectivist culture should have a strengthening effect on social relations of achievement motivation. The research results provide essential findings; namely, there is an indication of the transformation of cultural dimensions in the Z Generation who were participants in this research, so that the cultural dichotomy of individualism and collectivism becomes meaningless in the relationship among teacher-student relations and peer relations with achievement motivation. This research provides essential information on the development of science and future researchers to conduct a more comprehensive study of the dichotomy of the cultural dimensions of individualism and collectivism by involving two countries with different cultural backgrounds because cultural transformation is possible.
Population Mobility in Croatia from a Life Course Perspective

Rad istražuje unutarnju mobilnost stanovnistva u Hrvatskoj iz perspektive životnoga ciklusa. U nedostatku kohortnih podataka o unutarnjoj migraciji primjenom metoda tablice doživljenja omogucena je procjena cjeloživotne prostorne pokretljivosti stanovnistva. Ishod je ocekivana migracija, odnosno prosjecni ocekivani broj preseljenja za pojedinca tijekom njegova životnog vijeka (uz uvažavanje djelovanja mortaliteta). Za izracun ocekivane migracije upotrijebljeni su popisni podaci o stanovnistvu koje je promijenilo mjesto stanovanja od 1. travnja 2010. do 31. ožujka 2011. Rezultati provedene analize pokazuju sljedece: žene u Hrvatskoj prostorno su pokretljivije od muskaraca, a to vrijedi i kad se u obzir uzmu spolne razlike u mortalitetu ; ocekivana migracija s dobi postupno pada, no distribucija preseljenja neujednacena je tijekom životnoga ciklusa. Najveca sklonost unutarnjoj mobilnosti bilježi se, nimalo iznenađujuce, kod mladoga odraslog stanovnistva, sto potvrđuju i procjene modelskoga dobnog profila unutarnjih migranata u Hrvatskoj. Vrhunac intenziteta unutarnje migracije javlja se tijekom dvadesetih godina života. Istovremeno, unutarnja mobilnost stanovnistva u Hrvatskoj komparativno je jako niska, sto se, između ostaloga, može pripisati nacinu rjesavanja stambenoga pitanja, ekonomskim i drustvenim prilikama. Pri interpretaciji istraživackih nalaza izloženih u ovome radu valja imati na umu da se ocekivana migracija temelji na presjecnim podacima i iskustvu sinteticke kohorte. Rijec je o pokazatelju koji se odnosi na prosjecne vrijednosti, zbog cega može prikrivati važne informacije o varijacijama u migracijskome ponasanju. Bez obzira na spomenuto ogranicenje ocekivana migracija predstavlja lako razumljivu i prakticnu mjeru koja omogucuje detaljno sagledavanje vremenskoga rasporeda prostorne pokretljivosti i tako nadopunjuje postojece spoznaje o unutarnjoj mobilnosti stanovnistva u Hrvatskoj.
Does Flexible Working Time Make Start-up Company Workers More Engaged?

Currently, one business model that is particularly prevalent in Indonesia and has an impact on state revenue is start-up. There is one technology start-up in Indonesia that also influences economic development in Indonesia, namely company X. Behind the good performance of technology start-ups, there are roles of workers, culture, and the environment. Start-up X has a culture, namely a flexible work arrangement in which employees can have the freedom to choose when and where to work. This flexibility also has a lot of impact on the way of work and also the daily life of the workers. Flexible work arrangement (FWA) works as resources in a company. The high freedom affects workers’ engagement. Thus, the purpose of this study was to determine the effect of flexible work arrangements on the work engagement of employees at Start-up Company X. This research was conducted on 102 workers selected with a convenience sampling technique. This study uses a non-experimental research design with a correlational study method. Data collection was carried out using the Flexible Work Arrangement measuring tool adapted from Umi Farida (2020) and the Indonesian Utrecht Work Engagement Scale (UWES)-17 questionnaire from Schaufeli (2004). The results of this study indicate that there is a significant effect (p<0.001; R2=0.245) of the flexible work arrangement on the work engagement of employees at start-up company X. It means if there is a change in flexible work arrangement, it will impact the result of the work engagement. Our research adds new insights about the impact of FWA and WE variables on startup companies. Furthermore, when FWA is supported by adequate job resources and balanced with job demands, it can improve employee’s WE in startup companies. This study can provide information on future research on FWA and WE variables in start-up companies and with FWA supported by job resources that are balanced with job demand, will increase the WE of start-up company workers.
Properties of High-Entropy Fe30Co20Ni20Mn20Al10 Alloy Produced by High-Energy Ball Milling

A high-entropy Fe30Co20Ni20Mn20Al10 (at%) alloy with a face-centered cubic (FCC) crystalline phase was produced through mechanical alloying. This study examined the development of its phases, microstructure, morphology, and magnetic characteristics. Scanning electron microscopy (SEM) was applied to assess the sample morphology in relation to milling times. The changes that the material underwent during milling were investigated using X-ray diffraction. The milling time affected the phase transformation. A single FCC solid solution (crystallite size = 12 nm) was found after 50 h of milling. Additionally, the magnetic characteristics were examined and shown to be associated with microstructural changes. The powder mixture exhibited behavior consistent with soft magnetics, with an Hc value of 8 Am−1 and an Ms value of 165 emu/g. The excellent soft magnetic characteristic may be related to the stability of the FCC phase, which was generated following a 30 h milling process. In addition, the low value of Ms may have originated from the presence of Al atoms in the solid solution and the development of large densities of interfaces and crystal defects.
3D modeling from outcrop data in a salt tectonic context: Example from the Inceyol minibasin, Sivas Basin, Turkey

AbstractWe have developed a 3D modeling strategy of the encased minibasin of Inceyol in Sivas (Turkey). The challenge lies in the combination of sparse outcrop data and the complex interpretive geometry of geologic structures that come from salt tectonics. We have succeeded in modeling the convoluted salt surface using an explicit indirect surface patch construction method followed by a manual mesh improvement. Then, we modeled the minibasin sediments with an implicit approach. The result highlighted the remarkable geometry of the convoluted salt horizon and its associated minibasin by extending in 3D the geologist’s interpretive 2D sections. This case study proved that building complex geometries is feasible with the existing tools and a good expertise in the various geomodeling techniques. Our work also underlined the need for new methods to ease the modeling of such tectonic features from sparse data. We have developed a 3D view of the model thanks to WebGL technology, as well as downloadable data to c.
Combining State-of-the-Art Pre-Trained Deep Learning Models: A Noble Approach for Skin Cancer Detection Using Max Voting Ensemble

Skin cancer poses a significant healthcare challenge, requiring precise and prompt diagnosis for effective treatment. While recent advances in deep learning have dramatically improved medical image analysis, including skin cancer classification, ensemble methods offer a pathway for further enhancing diagnostic accuracy. This study introduces a cutting-edge approach employing the Max Voting Ensemble Technique for robust skin cancer classification on ISIC 2018: Task 1-2 dataset. We incorporate a range of cutting-edge, pre-trained deep neural networks, including MobileNetV2, AlexNet, VGG16, ResNet50, DenseNet201, DenseNet121, InceptionV3, ResNet50V2, InceptionResNetV2, and Xception. These models have been extensively trained on skin cancer datasets, achieving individual accuracies ranging from 77.20% to 91.90%. Our method leverages the synergistic capabilities of these models by combining their complementary features to elevate classification performance further. In our approach, input images undergo preprocessing for model compatibility. The ensemble integrates the pre-trained models with their architectures and weights preserved. For each skin lesion image under examination, every model produces a prediction. These are subsequently aggregated using the max voting ensemble technique to yield the final classification, with the majority-voted class serving as the conclusive prediction. Through comprehensive testing on a diverse dataset, our ensemble outperformed individual models, attaining an accuracy of 93.18% and an AUC score of 0.9320, thus demonstrating superior diagnostic reliability and accuracy. We evaluated the effectiveness of our proposed method on the HAM10000 dataset to ensure its generalizability. Our ensemble method delivers a robust, reliable, and effective tool for the classification of skin cancer. By utilizing the power of advanced deep neural networks, we aim to assist healthcare professionals in achieving timely and accurate diagnoses, ultimately reducing mortality rates and enhancing patient outcomes.
Related Factors of Work Stress Among Breastfeeding Working Women in Indonesia

Work stress is a common response experienced by workers, including breastfeeding working women, due to stressors arising in the workplace. In the short term, work stress has a negative impact on the productivity and lactation activity of working women. Therefore, this study aimed to investigate the factors associated with work stress among breastfeeding working women. A cross-sectional design was used by distributing the workplace stress scale questionnaire and additional questions to breastfeeding working women. The data used were obtained from 162 respondents spread across Indonesia who were willing to fill out online questionnaires. Subsequently, the collected data were analyzed using the Logistic Regression test. The results indicated that 85 people (52.47%) felt high stress, particularly regarding the lack of opportunity to show ability and talent during work. A statistically significant relationship (p=0.034, aOR= 2.139) was also discovered between the type of family and work-related stress in breastfeeding working women. Although this problem was directly sourced from stressors at work, demographic factors such as the type of family contributed to the stress experienced by breastfeeding working women.
Evaluation of genetic diversity of figs (Ficus carica L.) in Sulaymaniyah governorate using morphological, pomological and ISSR molecular marker

The fig (Ficus carica L.) is a fruit tree that is important in the Mediterranean region, and thus genetic improvement has become an important field of research for better crops, with information on this species, particularly its genetic variability correlated to morphological traits of figs, for this purpose, the cultivars and wild types distributed in Sulaymaniyah province were investigated. Samples from 66 fig accessions were collected, 15 primers for ISSR markers were used to describe genetic variation, with 12 morphological traits. Analysis of variance recorded highly signiﬁcant differences concerning plant morphological and pomological traits in addition to genetic diversity. The highest values for shoot length (79.959 cm), internode diameter (15.563 mm), leaf length (28.183 cm), leaf width (28.480 cm), leaf petiole length (13.397 cm) and leaf petiole diameter (18.360 mm) recorded in AC17, AC41, AC20, AC20, AC17 and AC24, respectively. However, the lowest values (11.120 cm, 4.340 mm, 10.910 cm, 9.813 cm, 3.987 cm and 2.323 mm) for the mentioned traits were recorded in AC14, AC12, AC12, AC12, AC37 and AC52, respectively. The highest values for fruit weight (63.447 g), fruit length (46.960 mm), fruit thickness (60.420 mm), fruit stalk length (29.887 mm), fruit stalk diameter (10.433 mm) and ostiole diameter (8.717 mm) were given by AC03, AC22, AC54, AC58, AC58 and AC14, successively. Whereas the lowest values (4.483 g, 14.770 mm, 18.497 mm, 2.373 mm, 2.533 mm and 2.557 mm) were observed in AC37, AC37, AC12, AC08, AC25 and AC30, successively. The first two principal components analysis (PCA) described 49.15% of the total quality variance. ISSR marker produced 197 polymorphic bands. The genetic diversities ranged as (0.883 to 0.980) and polymorphism information content (PIC) ranged as (0.878 to 0.979), with 100% polymorphism levels. The fig accessions classified into 10 clusters by dendrongram created by ward method. The results indicated that natural fig populations in this region provide a rich genetic resource for fig germplasms, and significant genetic variation across accessions originating from different populations, as well as the marker was informative for genetic variability detection in the collections. The findings of this study could support in the conservation and further utilization of fig germplasm.
Antioxidant and Antibacterial Activity of Different Solvent Extracts of Leaves and Stem of Alyxia reinwardtii Blume

Alyxia reinwardtii Blume (Pulasari) Apocynaceae is being widely used as a traditional medicine in treating various illnesses due to its phenolic, coumarins, lignans, iridoid glycosides alkaloids and flavonoids content. These compounds in A. reinwardtii were reported to be useful as medicinal and agricultural potentials. Hence, A. reinwardtii meets the rationale for antioxidant and antibacterial studies to replace synthetic substances using different solvents on the leaves and stem of A. reinwardtii using cold maceration. The Folin-Ciocalteu reagent assay was used to estimate the phenolic content of extracts. The total flavonoid content was determined using aluminum chloride. The antioxidant capacity of the samples was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and Ferric Reducing Antioxidant Power (FRAP) assay. Disc Diffusion Assay (DDA), Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) were conducted to evaluate the antibacterial activity of Escherichia coli and Bacillus cereus growth. Methanol was determined as the most effective solvent due to the highest crude yield obtained, (19.47 ± 2.80 %). Acetone showed the highest TPC content (170.44 ± 10.99 mg GAE/g) while hexane showed the highest TFC content (2957 ± 91.24 mg QE/g). Moreover, for DPPH, methanol inhibited the highest antioxidant (75.81 ± 12.62 %) and hexane for FRAP assay (2278.89 ± 69.47 mg AAE/g). Hexane extract is potentially effective with variable efficiency with DDA (11.17 ± 4.48 mm) while methanol extracts with MIC (0.63 μg/mL) and MBC (2.50 μg/mL) against E. coli. The results indicated that methanolic and hexane extract using cold maceration showed optimum antioxidant and antibacterial activity. The present study advocates that A. reinwardtii was a source of substantial antioxidant and antibacterial agents for potential pharmaceutical applications.
First report of dog ticks and tick-borne pathogens they are carrying in Malawi

Ticks are vectors for transmitting tick-borne pathogens (TBPs) in animals and humans. Therefore, tick identification is necessary to understand the distribution of tick species and the pathogens they carry. Unfortunately, data on dog ticks and the TBPs they harbor in Malawi are incomplete. This study aimed to identify dog ticks and the TBPs they transmit in Malawi. One hundred thirty-two ticks were collected from 87 apparently healthy but infested domestic dogs in four districts of Malawi, which were pooled into 128 tick samples. The ticks were morphologically identified under a stereomicroscope using identification keys, and species identification was authenticated by polymerase chain reaction (PCR) through the amplification and sequencing of 12S rRNA and cytochrome c oxidase subunit I (CO1) genes. The tick species identified were Rhipicephalus sanguineus sensu lato (58.3%), Haemaphysalis elliptica (32.6%), and Hyalomma truncatum (9.1%). Screening for TBPs using species-specific PCR assays revealed that 48.4% of the ticks were infected with at least one TBP. The TBP detection rates were 13.3% for Anaplasma platys, 10.2% for Babesia rossi, 8.6% for B. vogeli, 6.3% for Ehrlichia canis, 3.9% for A. phagocytophilum, 3.1% for B. gibsoni, 2.3% for B. canis and 0.8% for Hepatozoon canis. Co-infections of up to three pathogens were observed in 48.4% of the positive samples. This is the first study to identify dog ticks and the TBPs they harbor in Malawi. These findings provide the basis for understanding dog tick distribution and pathogens they carry in Malawi. This study necessitates the examination of ticks from more study locations to have a better picture of tick challenge, and the development of ticks and tick-borne disease control methods in Malawi.
Blue Bay as a Sub-Satellite Ground for Evaluating Hydrochemical Characteristics in the Shelf Areas of the Crimea

Assessment of state and quality of the sea and ocean surface layer waters resulted from binding the data from satellite images and the results of the simultaneously done in situ measurements is the actual direction of modern complex oceanological studies. Further development of this direction the immediate task of which consists in defining hydrochemical composition of water based on satellite data requires selecting the regions in the Black Sea where in situ measurements of water hydrochemical characteristics can be carried out simultaneously with satellite monitoring of the surface water state. The results of analysis of the hydrochemical characteristics’ (main elements of nutrient and carbon cycles) spatial distribution in the Blue Bay waters based on the data of the expeditionary research carried out by Marine Hydrophysical Institute in 2002–2014 are represented. It is shown that this region and the stationary oceanographic platform (SOP) located in its southwestern part constitute a convenient ground for synchronous remote and sub-satellite studies of natural oceanological processes and impact of the coastal anthropogenic pollution sources. The data on hydrochemical characteristics of surface water in the SOP region can be used to study background state of the coastal marine environment as well as influence of intense natural processes (storms and (or) upwellings) upon formation and evolution of hydrochemical and optical structure of surface waters, surface water and atmosphere gas exchange, effect of physical, chemical and biological processes on the sea water quality. Influence of two coastal sources of anthropogenic pollution upon the Blue Bay marine environment was studied using synchronous remote and sub-satellite measurements; the results of these investigations provide additional opportunities for developing and certifying the methods of remote study and monitoring of the coastal marine environment state.