Miracle-dz/UniFAR-FTUs huggingface dataset:
The XXmotif web server for eXhaustive, weight matriX-based motif discovery in nucleotide sequences

The discovery of regulatory motifs enriched in sets of DNA or RNA sequences is fundamental to the analysis of a great variety of functional genomics experiments. These motifs usually represent binding sites of proteins or non-coding RNAs, which are best described by position weight matrices (PWMs). We have recently developed XXmotif, a de novo motif discovery method that is able to directly optimize the statistical significance of PWMs. XXmotif can also score conservation and positional clustering of motifs. The XXmotif server provides (i) a list of significantly overrepresented motif PWMs with web logos and E-values; (ii) a graph with color-coded boxes indicating the positions of selected motifs in the input sequences; (iii) a histogram of the overall positional distribution for selected motifs and (iv) a page for each motif with all significant motif occurrences, their P-values for enrichment, conservation and localization, their sequence contexts and coordinates. Free access: http://xxmotif.genzentrum. lmu.de.
Gene copy number regulates the production of the human chemokine CCL3‐L1

Genetic variation in the chemokine system is likely to affect responses to infection, and influence the course of autoimmune and inflammatory disease. We and others have shown that the human β‐chemokine CCL3‐L1, unlike its related non‐allelic isoform CCL3, has high affinity for the chemokine receptors D6, CCR3 and CCR5. Moreover, CCL3‐L1, but not CCL3, is susceptible to cleavage by CD26, creating a truncated –2 form with enhanced affinity for CCR1 and CCR5. Strong interaction with CCR5 means that CCL3‐L1, and particularly its –2 variant, are by far the most potent natural HIV entry inhibitors described to date. Here, using real‐time PCR we have shown that CCL3‐L1 and a novel CCL4 isoform (termed CCL4‐L1) can vary from 1‐6 copies per diploid genome (pdg) in Caucasians and are occasionally completely absent. The other isoforms (CCL3 and CCL4) remain at two copies per dpg. Importantly, in a model system of pro‐inflammatory chemokine production (LPS‐activated monocytes)higher gene copy number correlates with an increased ratio of CCL3‐L1 versus CCL3 mRNA, and enhanced chemokine production. Supernatants from samples with high copy number are able to more potently chemoattract CCR5‐expressing cells, an effect blocked with anti‐CCL3/CCL3‐L1 antibodies. As a result of these studies, we hypothesize that genetic variation in CCL3‐L1 gene copy number may affect the susceptibility to, or the progression or severity of, diseases in which this chemokine plays a role.
Collapsed buildings extraction using morphological profiles and texture statistics - A case study in the 5.12 wenchuan earthquake

The paper proposes a method of collapsed buildings extraction from post-earthquake airborne images. Firstly, training and validation samples are selected, and feature extraction is conducted through morphological profiles and texture statistics based on gray-level co-occurrence matrix, and then support vector machine classifier is used to extract collapsed buildings. An initial experiment is carried out on images acquired after the 5.12 wenchuan earthquake. Results show that morphological features and texture features are complementary to each other in describing collapsed buildings; a reasonable extraction result is achieved based on these two kinds of features. However, due to the complexity of collapsed buildings in airborne images, more work is needed such as introducing more features and also a proper feature reduction method.
Speckle Suppression Method in SAR image Based on Curvelet Domain BivaShrink Model

Based on the statistical property of SAR image speckle noise and the property that the multiscale geometric analysis can capture the intrinsic geometrical structure of image, combining curvelet transform with BivaShrink denoising model, a method of SAR image denoising based on curvelet domain is presented in this paper. According to calculation of variance homogeneous measurement and curvelet coefficients of current layer and its parent layer, the local adaptive window is determined to optimally estimate shrinkage factor. The method can effectively reduce SAR speckle noise and preserving details of SAR image well through the correlation of curvelet coefficients in the same direction of subband and parent-layer subband. The experimental results show the presented method greatly improves the subjective visual effect and the numerical indicators of the denoised image.
On the Suitability of Load Bala Heterogeneous Wireless A

Initial RAT selection is a key Common RRM strategy, where users requiring service are to be efficiently allocated in the existing and available RATs. Although load balancing is a possible guiding allocation principle, sometimes it may not be convenient. This paper evaluates and compares a load balancing and a service-class RAT selection policy in order to discuss the suitability of the former in situations where different service-class mixings are present. Results indicate a tight dependency between this appropriateness and the mixing of demanding services.
DSP-centric algorithms for distributed transmit beamforming

Distributed transmit beamforming is a means of increasing range and power efficiency via local collaboration among neighboring nodes in order to transmit a common message to a remote destination. While its basic feasibility has been established by recent analyses and prototypes, transitioning this concept to applications requires the development of protocols and architectures which can be implemented efficiently using digital signal processing (DSP). In this paper, we describe DSP-centric algorithms and their performance limits, and report on recent results from simulations and software-defined radio experiments.
PLANNING A STATEWIDE TRAINING NETWORK: A CASE STUDY IN DEVELOPING INTERORGANIZATIONAL RELATIONSHIPS

The study describes and analyzes a statewide project to plan, design, and implement an ongoing training network for inservice education of professionals and practitioners working in the field of aging. Specifically, the state agency on aging, through its planning and contracting process, attempted to establish and strengthen the communication and interactive relationship among the various agencies working with the elderly and with educational institutions and their personnel. The development of an ongoing statewide system of interorganizational relationships has proven effective in bridging the gap between the acquisition of knowledge and the application of that knowledge in the delivery of services and the development of policy. Although this study describes only the training program of the state agency on aging, its success suggests its applicability to training in other fields in human services. Currently, a statewide interagency Task Force on Title XX Training and Retraining has undertaken planning fo.
Taxonomic counts of cognition in the wild

In 1985, Kummer & Goodall pleaded for an ecology of intelligence and proposed that innovations might be a good way to measure cognition in the wild. Counts of innovation per taxonomic group are now available in hundreds of avian and primate species, as are counts of tactical deception, tool use and social learning. Robust evidence suggests that innovation rate and its neural correlates allow birds and mammals to cope better with environmental change. The positive correlations between taxonomic counts, and the increasing number of cognitive and neural measures found to be associated with ecological variables, suggest that domain general processes might be more pervasive than previously thought in the evolution of intelligence.
A deeper understanding of evolution of the role of the object in organizational process: The concept of “mediation object”

Purpose – The purpose of this paper is to analyze the different roles and natures of objects in organizational process. Furthermore, the concept of the mediation object is developed to understand how the objects help to structure interactions and collective activities over time.Design/methodology/approach – The paper employs data from a case study (the Pupitre Virtuel) in order to highlight and illustrate the relevance of a process analysis of the roles and natures of objects.Findings – The paper demonstrates that the roles and natures of objects evolve over time through controversies and compromises. On one hand, the evolution of interactions drives the evolution of the roles and natures of objects. On the other, the evolution of objects help the actors to structure their interactions and activities.Originality/value – The paper argues that, rather than a static analysis, human‐object interaction needs to be understood and observed through a process analysis, taking into account the evolution of objects .
Death of the VLE?: a challenge to a new orthodoxy

The VLE has become almost ubiquitous in both higher and further education, with the market becoming increasingly 'mature'. E-learning is a major plank in both national and institutional strategies. But, is the VLE delivering what is needed in a world where flexibility of learning is para mount, and the lifelong learner is becoming a reality? There are indications that rather than resulting in innovation, the use of VLEs has become fixed in an orthodoxy based on traditional educational approaches. The emergence of new services and tools on the web, dev elopments in interoperability, and changing demands pose significant issues for institutions' e-learning strategy and policy. Whether the VLE can remain the core of e-learning activity needs to be considered.
The Optimal Copula Choice of Index-Related under the Financial Crisis

This article focuses on the dependence of DJI and HIS under the present financial crisis, applying nonparametric kernel density estimation to fit marginal distribution, using maximum likelihood estimation (MLE) to estimate parameters of Copula and adopting different treatments of Kolmogorov-Smirrnov test to choose the best Copula among Archimedes Copulas and Mixed Clayton Copulas. The caulated outcomes show that the Mixed Clayton copula with weight value 0.61 is the optimal Archimedean copula which can illustrate the correlation between DJI and HIS. Moreover, the tail dependence analysis shows that it presents asymmetry, and lower tail's dependence is higher than upper tail's dependence. The fierce fall of DJI's return caused by financial crisis induced fiercer correlated responses on HIS's return, which shows financial crisis's negative influence is tremendous.
Cyclic Codes

Among the first codes used practically were the cyclic codes which were generated using shift registers. It was quickly noticed by Prange that the class of cyclic codes has a rich algebraic structure, the first indication that algebra would be a valuable tool in code design. The linear code C of length n is a cyclic code if it is invariant under a cyclic cyclic code As C is invariant under this single right cyclic shift, by iteration it is invariant under any number of right cyclic shifts. As a single left cyclic shift is the same as n − 1 right cyclic shifts, C is also invariant under a single left cyclic shift and hence all left cyclic shifts. Therefore the linear code C is cyclic precisely when it is invariant under all cyclic shifts. There are some obvious examples of cyclic codes. The 0-code is certainly cyclic as is F n. Less trivially, repetition codes are cyclic. The binary parity check code is also cyclic, and this goes over to the sum-0 codes over any field. Notice that this shift invariance criterion does not depend at all upon the code being linear. It is possible to define nonlinear cyclic codes, but that is rarely done. The history of cyclic codes as shift register codes and the mathematical structure theory of cyclic codes both suggest the study of cyclic invariance in the context of linear codes.
The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma

Aims To determine the influence of prostaglandin analogues (PGAs) on corneal biomechanical properties in patients undergoing chronic treatment for primary open-angle glaucoma (POAG). Methods Prospective, interventional case–control study. 70 eyes from 35 patients with POAG on chronic PGA therapy were recruited. One eye per patient underwent PGA cessation for 6 weeks while the contralateral eye continued to receive the treatment. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOP) (IOPcc), central corneal thickness (CCT) and Goldmann tonometry (Haag-Streit AG, Koeniz, Switzerland) IOP (IOPGAT) were measured at baseline (visit 1), 6 weeks after PGA cessation (visit 2) and 6 weeks after PGAs reinitiation (visit 3) and were analysed using a linear mixed-effect model. The discrepancy between IOPcc and IOPGAT was defined as IOP bias (IOPcc—IOPGAT). Results Baseline characteristics were comparable between the two groups. In the study eyes, significant increases (p<0.0001) were detected at visit 2 in CH (9.0±1.8 vs 10.3±1.7 mm Hg), CRF (10.5±2.1 vs 11.7±2.1 mm Hg), CCT (541.8±43.2 vs 551.9±41.9 μm) and IOPGAT (15.4±3.0 vs 18.4±3.8 mm Hg). IOP bias in this group was significantly lowered at visit 2 (p<0.0001). These effects were reversed at visit 3. The control eyes did not demonstrate any significant changes over the study period. Conclusion Topical PGAs induce reversible reduction in CH, CRF and CCT in patients with POAG. These changes contribute to underestimation of the IOP measured by Goldmann applanation tonometry and warrant caution when assessing response to treatment. Trial registration number NCT02388360, Results.
Functions of Difference Matrices Are Toeplitz Plus Hankel

When the heat equation and wave equation are approximated by $\bm{u}_t = -\bm{K} \bm{u}$ and $\bm{u}_{tt} = -\bm{K} \bm{u}$ (discrete in space), the solution operators involve $e^{-\bm{K}t}$, $\sqrt{\bm{K}}$, $\cos(\sqrt{\bm{K}}t)$, and $\mathrm{sinc}(\sqrt{\bm{K}}t)$. We compute these four matrices and find accurate approximations with a variety of boundary conditions. The second difference matrix $\bm{K}$ is Toeplitz (shift-invariant) for Dirichlet boundary conditions, but we show why $e^{\bm{-Kt}}$ also has a Hankel (anti-shift-invariant) part. Any symmetric choice of the four corner entries of $\bm{K}$ leads to Toeplitz plus Hankel in all functions $f(\bm{K})$. Overall, this article is based on diagonalizing symmetric matrices, replacing sums by integrals, and computing Fourier coefficients.
Separation-individuation of Portuguese emerging adults in relation to parents and to the romantic partner

Separation-individuation is one of the main developmental tasks for emerging adults in the transition to adulthood and can be defined as the ability to gain autonomy within relatedness in attachment relationships. The aim of this study is to explore the current relationship dynamics of parent–child separation-individuation and to examine the links between this developmental task of emerging adults and the ability to establish an autonomous and differentiated self in an intimate relationship with a romantic partner. Separation-individuation was measured with the Munich Individuation Test of Adolescence (MITA), a self-report instrument that allows the assessment of individuation dimensions towards mother, father, and romantic partner. Participants were 463 Portuguese emerging adults between 18 and 30 years of age, mostly university students. Results point to the existence of different individuation styles that reflect distinct relationships dynamics, as well as gender, age and parental figure differences in the development of an autonomous sense of self within close relationships. In addition, results showed an articulation between individuation dynamics concerning parents and the romantic partner that is associated with participants’ individuation style and relationship length, thus supporting the main hypothesis.
Pilot Subset Partitioning Based Integer Frequency Offset Estimation for OFDM Systems With Cyclic Delay Diversity

Cyclic delay diversity (CDD) is a simple transmit diversity technique for coded OFDM systems with multiple transmit antennas. However, high frequency selectivity caused by CDD degrades the performance of post- FFT estimation, i.e., integer frequency offset (IFO). This paper suggests a simple way of improving the performance of the IFO estimator based on the pilot subset partitioning which is designed to reduce the effect of frequency selective fading by adopting the CDD. By partitioning uncorrelated pilot subcarriers into subsets to satisfy high correlation, and performing frequency estimation for each pilot subset, a robust IFO estimation scheme is derived. The simulation results show that the proposed method can provide benefit to the overall system performance .
War and Democratization: Lessons from the Portuguese Experience

The literature on democracy suggests that new democracies should have difficulty emerging during war or in the aftermath of armed struggle, yet Portugal's current democracy emerged simultaneously with the end of the nation's unsuccessful war in Africa. This article addresses the reasons and argues that democracy triumphed not simply in spite of the war but also, in part, because of it. The costs and geography of the war itself, the capacity and rootedness of the state that waged the war, the political culture of the regime's military officers, and the war-related timing of Portugal's first elections all helped prevent the emergence of an anti-democratic coalition and contributed to ensuring a successful transition to democracy. The article ends with three ideas that merit closer examination: that different sorts of wars leave different legacies for democracy; that wars that leave state bureaucracies intact or stronger are more likely to be followed by lasting democracy than those which do not; and, finally, that the ideologies of military elites are pivotal to the outcome of post-war democratic transitions.
Extremum seeking from 1922 to 2010

Extremum seeking is a form of adaptive control where the steady-state input-output characteristic is optimized, without requiring any explicit knowledge about this input-output characteristic other than that it exists and that it has an extremum. Because extremum seeking is model free, it has proven to be both robust and effective in many different application domains. Equally being model free, there are clear limitations to what can be achieved. Perhaps paradoxically, although being model free, extremum seeking is a gradient based optimization technique. Extremum seeking relies on an appropriate exploration of the process to be optimized to provide the user with an approximate gradient, and hence the means to locate an extremum. These observations are elucidated in the paper. Using averaging and time-scale separation ideas more generally, the main behavioral characteristics of the simplest (model free) extremum seeking algorithm are established.
Adding passive biarticular spring to active mono-articular foot prosthesis: Effects on power and energy requirement

Current active foot prostheses try to emulate the foot function by using a mono-articular series elastic actuator (SEA). In humans, a bi-articular actuation scheme is used to plantar-flex the foot through Soleus and Gastrocnemius muscles (in plantar-flexion the angle between foot and shank increases). In this study we investigated on using a bi-articular actuation scheme in active foot prostheses (where a passive bi-articular spring is added to an active mono-articular actuator). For design of these robotic systems, motor peak power (PP) and energy (E) requirement are two important factors. Lower PP or E requirement lead to a smaller motor or battery, hence decreasing the weight and increasing the performance capacity of the device. For this purpose, we compared the PP and E requirement of the mono- and the proposed bi-articular actuation models for active foot prostheses. The simulation results showed that for normal running (2.6 m/s), the PP requirement of the proposed bi-articular actuation can decrease about 54% in comparison to the mono-articular actuation. For normal walking (1.55 m/s), the required PP can reduce about 38%. On the other side, the corresponding E requirement can reduce about 7% for running, however, for walking, it can increase about 8%. In addition, it was found out that, if the spring is attached to the shank, the average results of the PP and E requirements are higher than the bi-articular scheme, however the differences were not very noticeable. Thus, our study shows that for designing a powered prosthesis both methods can be used. As the bi-articular spring can also influence the knee joint power of a trans-tibial amputee, the engineering advantages should be taken into account together with the user's comfort.
ENERGY DETECTION BASED SPECTRUM SENSING FOR COGNITIVE RADIO

Cognitive Radio is an emerging technology which avoids the congestion in wireless communication by exploiting unused radio spectrum . The Spectrum sensing plays a fundamental requirement of CR which finds an unused free spectrum and detects the licensed user transmissions.energy detection constitutes a preferred approach for cognitive rdio spectrum sensing due to its simple applicability. In this paper Wiener khinchin theorem ,QAM techniques are used for the energy detection
Workaholism as a Risk Factor for Depressive Mood, Disabling Back Pain, and Sickness Absence

Objectives Although it is understood that work-related factors, including job demands, job control, and workplace support, are associated with workers' health and well-being, the role played by personal characteristics, especially workaholism, has not been fully investigated. This study examined workaholism's associations with psychological ill health, low back pain with disability, and sickness absence among Japanese workers. Methods A cross-sectional Internet survey was conducted using self-administered questionnaires. Data from 3,899 Japanese workers were analyzed. Workaholism was measured using the Dutch Workaholism Scale (DUWAS). Scores were divided into tertiles, where respondents were classified into three groups (high, middle, and low). Depressive mood as a measure of psychological ill health was assessed using the SF-36 mental health subscale, and low back pain using a standardized question. Sickness absence, except that due to physical injuries, was categorized either as absence due to mental health problems or to physical/somatic problems including the common cold. Multiple logistic regression analyses were conducted to examine the association between workaholism and depressive mood, low back pain with disability, and sickness absence, adjusting for demographic characteristics, job demand, job control, and workplace support. Results Compared to the low workaholism group, the middle and high workaholism groups had significantly higher odds for depressive mood (Odds ratio (OR) = 1.93 and 3.62 for the middle and high groups, respectively), disabling back pain (ORs = 1.36 and 1.77 for the middle and high groups, respectively). Workaholism was more strongly associated with sickness absence due to mental health problems than that for other reasons (ORs = 1.76 vs. 1.21 for the middle group and 3.52 vs. 1.37 for the high groups). Conclusions Workaholism is significantly associated with poor psychological health, disabling back pain, and sickness absence, particularly from mental health problems. Therefore, workaholism must be considered when addressing well-being of workers.