Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and Tolerability of a Scutellaria lateriflora L. and Cistus × incanus L.-Based Chewing Gum on the Symptoms of Gingivitis: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Preclinical studies have shown that the combination of Cistus × incanus L. and Scutellaria lateriflora L. extracts exerts beneficial effects on oral health against gingivitis. Thus, this study aimed to assess the tolerability of a chewing gum and its efficacy on gingivitis in a double-blind, placebo-controlled clinical trial. Enrolled subjects (n = 60, 18–70 years) were randomized to receive two chewing gums or a placebo daily for 3 months. At baseline (t0) and monthly (t1, t2, and t3) timepoints, the Quantitative Gingival Bleeding Index (QGBI), the Modified Gingival Index (MGI), and the Oral Health 15 items (OH-15)] were employed to assess potential improvements in gingivitis. Pain was self-quantified via the Visual Analogue Scale (VAS), and the Clinical Global Impression Scale for Severity of illness (CGI-S) helped in evaluating the oral general conditions. This study is listed on the ISRCTN registry. At t3, the QGBI, MGI, OH-15, VAS, and CGI-S values decreased in the treated but not in the placebo group (β = 0.6 ± 0.1, t176 = 3.680, p < 0.001; β = 0.87 ± 0.21, t115 = 4.263, p < 0.001; β = 5.3 ± 2.5, t172 = 2.086, p = 0.038; β = 3.16 ± 0.51, t88 = 6.253, p < 0.001; and β = 1.09 ± 0.32, t83 = 3.419, p < 0.001, respectively). A significant improvement in gingival health occurred after a 3-month intervention with the chewing gums containing S. lateriflora and C. incanus extracts.
Classification of the behavior disorders.

An essential step for clarifying a field that is as confused as the clas­ sification of behavior disorders is to provide some specific definitions for the terms to be used. While definitions can never be rigorous and complete except in mathematics, they nevertheless serve to demarcate a concept even though its boundaries remain somewhat blurred. Classification, following Hempel (19), divides a set of objects into subclasses according to certain common characteristics. In the field of behavior disorders, a classification system attempts to classify the population of those suffering from behavior disorders into diagnostic subgroups according to certain common signs, symptoms, and other identifying characteristics. The resulting classification system will depend upon several basic considerations. First, is the goal of the classification, second, the definition of the universe of patients, and third, the specification of the various subcategories into which the popula­ tion under examination is classified. Variations in these goals and definitions will result in placing the same individual in different categories or in an excluded category outside of the universe of discourse. For this reason it is important to define the goals, the universe of discourse, and the subcategories according to which classification is made. The main purpose of diagnosis is threefold: aetiology, prognosis, and selection of therapy. The search for aetiology consists of finding the group of possible causative factors accounting for the symptoms and signs and then the diseases which are associated with these causes. From this group of diseases the most likely and the least likely are separated and further testing initiated to determine which disease is the most probable. Once the diagnosis is arrived at, the clinical data are used to estimate how the pa­ tients who fall into the given disease category will fare under the va­ riety of treatments available and to discover to which subgroup the patient in question belongs, so as to select for him the most suitable therapy. Another use is made of the clinical data. Not alI the signs and symp­ toms observed by the clinician constitute a part of the syndrome basic to the disorder. Some of these signs and symptoms, distressing though they
Diagnosis and classification of personality disorder: difficulties, their resolution and implications for practice

There are many difficulties associated with the diagnostic guidelines for personality disorder in the current international classificatory systems such as ICD–10 and DSM–IV. These lead not only to significant overlap with DSM Axis I disorders, resulting in high rates of diagnoses of comorbidities and multiple personality disorders, but also to lack of adequate capture of core personality pathology. The current classifications are also unhelpful in treatment selection, presumably the prime reason for assessing individuals in the first place. In this article we highlight various deficits and inadequacies related to the nosology of the current systems and suggest some strategies for dealing with these. We offer an integrated model of assessing and diagnosing personality disorders. We attempt to demonstrate how using a more integrated approach minimises or even eliminates some of the key problems highlighted in the current systems.
Accuracy of grading of urothelial carcinoma on urine cytology: an analysis of interobserver and intraobserver agreement.

BACKGROUND Urine samples of known urothelial carcinoma were independently graded by 3 pathologists with (MS, MR) and without (AO) fellowship training in cytopathology using a modified version of the 2004 2-tiered World Health Organization classification system. By measuring interobserver and intraobserver agreement among pathologists, compared with the gold standard of biopsy/resection, specimen accuracy and reproducibility of grading in urine was determined. METHODS 44 urine cytology samples were graded as low or high-grade by 3 pathologists with a 2-3 week interval between grading. Pathologists were blinded to their and others' grades and histologic diagnoses. Coefficient kappa was used to measure interobserver and intraobserver agreement among pathologists. Accuracy was measured by percentage agreement with the biopsy/resection separately for each pathologist, and for all pathologists and occasions combined. RESULTS The overall accuracy was 77% (95% C.I., 72%-82%). Pathologist AO was significantly more accurate than MR on occasion 1 (p = 0.006) and 2 (p = 0.039). No other significant differences were found among the observers. Interobserver agreement using coefficient kappa was unacceptably low, with all but one of the kappa value being less than 0.40, the cutoff for a "fair" degree of agreement. Intraobserver agreement, as measured by coefficient kappa, was adequate. CONCLUSIONS Our study underscores the lack of precision and subjective nature of grading urothelial carcinoma on urine samples. There was poor inter- and intraobserver agreement among pathologists despite fellowship training in cytopathology. Clinicians and cytopathologists should be mindful of this pitfall and avoid grading urothelial carcinoma on urine samples, especially since grading may impact patient management.
Bayes-Nash equilibria for mth price auctions with multiple closing times

In this paper we compute Bayes-Nash equilibria for first price single unit auctions and mth price multi unit auctions, when the auction has a set of possible closing times, one of which is chosen randomly for the auction to end at. Thus the auctions have one or more rounds of sealed bids. We compute such equilibria for a wide range of assumptions and demonstrate the method used by an agent to generate these strategies.
Polystichum lilianae sp. nov. (Dryopteridaceae) and its relationships to P. fournieri and P. turrialbae

Morphological, isozyme, and cytological analyses of the small, pale-scaled polystichums from oakdominated montane rain forests in Costa Rica and Mexico reveal the presence of a separable undescribed species endemic to the Cordillera de Talamanca of Costa Rica. The new taxon,Polystichum lilianae, is an allotetraploid hypothesized to have the sympatricP. turrialbae as one diploid progenitor based on isozyme characters. The isozyme and morphometric data also support the inclusion ofP. smithii, described from southern Mexico, inP. turrialbae, described from Costa Rica. The namePolystichum fournieri, formerly used for all of these plants, applies to species endemic to Oaxaca and Chiapas, Mexico. It is not a progenitor ofP. lilianae. ResumenAnálisis de morfología, isozimas y cromosomas de poblaciones dePolystichum de las selvas montañosas Iluviosas de Costa Rica y México indican que existe una nueva especie endémica en la Cordillera de Talamanca de Costa Rica. La especie nueva,Polystichum lilianae, es allotetraploide y parece tener la especie simpátricaP. turrialbae como una de sus progenitores diploides. Además, datos morfológicos y de isozimas sugieren queP. turrialbae incluye como sinonimoP. smithiil del sur de México. Polystichum fournieri, nombre anteriormente usado para todas estas plantas, es endémica a Oaxaca y Chiapas, México, y no es un progenitor deP. lilianae.
Media Transportation and Advertising

Advertising is commonly presented in the context of media articles or programs that are intended to engage the consumer. An important aspect of this engagement is media transportation, where a person not only attends to information but also is absorbed into the narrative flow of a story in a pleasurable and active way. This research examines the effects of the transportation experience produced by the media context on the impact of ads that appear in that context. Three studies show that transportation can have both positive and negative effects on advertising. Intrusion of the ad into the transportation process is shown to mediate the negative effects, which occurs independently of involvement.
The psychobiology of comfort eating: implications for neuropharmacological interventions

Comfort eating, that is eating induced by negative affect, has been a core theme of explanations for overeating and obesity. Psychobiological explanations and processes underlying comfort eating are examined, as well as its prevalence in clinical and nonclinical populations, to consider who may be susceptible, whether certain foods are comforting, and what the implications for treatment may be. Comfort eating may occur in a substantial minority, particularly in women and the obese. Human and animal theories and models of emotional or stress-induced eating show some convergence, and may incorporate genetic predispositions such as impulsivity and reward sensitivity, associated with dopamine dysregulation underlying incentive salience. Comfort eaters show vulnerability to depression, emotional dysregulation and a need to escape negative affect and rumination. During negative affect, they preferentially consume sweet, fatty, energy-dense food, which may confer protection against stress, evidenced by suppression of the hypothalamic–pituitary–adrenal axis response, although activation of the hypothalamic–pituitary–adrenal axis may itself drive appetite for these palatable foods, and the risk of weight gain is increased. Benefits to mood may be transient, but perhaps sufficient to encourage repeated attempts to prolong mood improvement or distract from negative rumination. Cognitive behavioural treatments may be useful, but reliable drug therapy awaits further pharmacogenomic developments.
Nelfinavir Inhibits Intra-Mitochondrial Calcium Influx and Protects Brain against Hypoxic-Ischemic Injury in Neonatal Mice

Nelfinavir (NLF), an antiretroviral agent, preserves mitochondrial membranes integrity and protects mature brain against ischemic injury in rodents. Our study demonstrates that in neonatal mice NLF significantly limits mitochondrial calcium influx, the event associated with protection of the brain against hypoxic-ischemic insult (HI). Compared to the vehicle-treated mice, cerebral mitochondria from NLF-treated mice exhibited a significantly greater tolerance to the Ca2+-induced membrane permeabilization, greater ADP-phosphorylating activity and reduced cytochrome C release during reperfusion. Pre-treatment with NLF or Ruthenium red (RuR) significantly improved viability of murine hippocampal HT-22 cells, reduced Ca2+ content and preserved membrane potential (Ψm) in mitochondria following oxygen-glucose deprivation (OGD). Following histamine-stimulated Ca2+ release from endoplasmic reticulum, in contrast to the vehicle-treated cells, the cells treated with NLF or RuR also demonstrated reduced Ca2+ content in their mitochondria, the event associated with preserved Ψm. Because RuR inhibits mitochondrial Ca2+ uniporter, we tested whether the NLF acts via the mechanism similar to the RuR. However, in contrast to the RuR, in the experiment with direct interaction of these agents with mitochondria isolated from naïve mice, the NLF did not alter mitochondrial Ca2+ influx, and did not prevent Ca2+ induced collapse of the Ψm. These data strongly argues against interaction of NLF and mitochondrial Ca2+ uniporter. Although the exact mechanism remains unclear, our study is the first to show that NLF inhibits intramitochondrial Ca2+ flux and protects developing brain against HI-reperfusion injury. This novel action of NLF has important clinical implication, because it targets a fundamental mechanism of post-ischemic cell death: intramitochondrial Ca2+ overload → mitochondrial membrane permeabilization → secondary energy failure.
Assessing Uncertainty in Simulation‐Based Maritime Risk Assessment

Recent work in the assessment of risk in maritime transportation systems has used simulation‐based probabilistic risk assessment techniques. In the Prince William Sound and Washington State Ferries risk assessments, the studies’ recommendations were backed up by estimates of their impact made using such techniques and all recommendations were implemented. However, the level of uncertainty about these estimates was not available, leaving the decisionmakers unsure whether the evidence was sufficient to assess specific risks and benefits. The first step toward assessing the impact of uncertainty in maritime risk assessments is to model the uncertainty in the simulation models used. In this article, a study of the impact of proposed ferry service expansions in San Francisco Bay is used as a case study to demonstrate the use of Bayesian simulation techniques to propagate uncertainty throughout the analysis. The conclusions drawn in the original study are shown, in this case, to be robust to the inherent uncertainties. The main intellectual merit of this work is the development of Bayesian simulation technique to model uncertainty in the assessment of maritime risk. However, Bayesian simulations have been implemented only as theoretical demonstrations. Their use in a large, complex system may be considered state of the art in the field of computational sciences.
A moving target detection algorithm based on combination of GMM and LBP texture pattern

It is important and difficult to improve the robustness of target detection in the field of computer vision. In order to realize the accurate extraction of moving objects in the context of complex scenes, this paper proposes a new algorithm for object detection based on texture feature and background modeling. Firstly, the traditional Gaussian mixture model is improved, and then the improved Gaussian mixture model and the LBP texture model are fused by probability matching. The experimental results show that the proposed algorithm has better performance for detecting moving targets compared with the traditional algorithm.
Motion correction in fMRI via registration of individual slices into an anatomical volume

An automated retrospective image registration based on mutual information is adapted to a multislice functional magnetic resonance imaging (fMRI) acquisition protocol to provide accurate motion correction. Motion correction is performed by mapping each slice to an anatomic volume data set acquired in the same fMRI session to accommodate inter‐slice head motion. Accuracy of the registration parameters was assessed by registration of simulated MR data of the known truth. The widely used rigid body volume registration approach based on stacked slices from the time series data may hinder statistical accuracy by introducing inaccurate assumptions of no motion between slices for multislice fMRI data. Improved sensitivity and specificity of the fMRI signal from mapping‐each‐slice‐to‐volume method is demonstrated in comparison with a stacked‐slice correction method by examining functional data from two normal volunteers. The data presented in a standard anatomical coordinate system suggest the reliability of the mapping‐each‐slice‐to‐volume method to detect the activation signals consistent between the two subjects. Magn Reson Med 41:964–972, 1999. © 1999 Wiley‐Liss, Inc.
A single queen single worker honey–bees approach to 3-SAT

Modelling the behavior of social insects has attracted much research recently. Although honey– bees exhibit many features that encourage their use as models for intelligent behavior, up to our knowledge, no attempt for using honey-bees as a basis for optimization has been made in the literature. Some of the features that distinguish honey–bees are division of labor, communication on the individual and group level, and cooperative behavior. This paper presents a novel search algorithm inspired by the marriage process in honey–bees. The algorithm is applied to a special class of the propositional satisfiability problems (SAT) known as 3–SAT, where each clause contains exactly three literals. Two versions of the proposed algorithm, which incorporate each a well known heuristic for SAT, are developed. The two heuristics employed for each version are GSAT and random walk. The objective of this paper is to scrutinize the algorithm and compare its behavior on 3–SAT against both heuristics alone. The analysis is undertaken using two parameters gleaned from biological concepts; these are, the colony size and the amount of time devoted for brood–care.
Temporal Trends in Survival Among Infants With Critical Congenital Heart Defects

OBJECTIVE: To evaluate the trends in survival for infants with critical congenital heart defects (CCHDs) and to examine the potential impact of timing of diagnosis and other prognostic factors on survival. METHODS: We performed a retrospective population-based cohort study in infants born with structural congenital heart defects (CHDs) between 1979 and 2005 and ascertained by the Metropolitan Atlanta Congenital Defects Program. We estimated Kaplan-Meier survival probabilities for 12 CCHD phenotypes by birth era and timing of diagnosis among infants without noncardiac defects or chromosomal disorders and used stratified Cox proportional hazards models to assess potential prognostic factors. RESULTS: Of 1 056 541 births, there were 6965 infants with CHDs (1830 with CCHDs). One-year survival was 75.2% for those with CCHDs (n = 1336) vs 97.1% for those with noncritical CHDs (n = 3530; P < .001). One-year survival for infants with CCHDs improved from 67.4% for the 1979–1993 birth era to 82.5% for the 1994–2005 era (P < .001). One-year survival was 71.7% for infants with CCHDs diagnosed at ≤1 day of age (n = 890) vs 82.5% for those with CCHDs diagnosed at >1 day of age (n = 405; P < .001). There was a significantly higher risk of 1-year mortality for infants with an earlier birth era, earlier diagnosis, and low birth weight and whose mothers were <30 years old. CONCLUSIONS: One-year survival for infants with CCHDs has been improving over time, yet mortality remains high. Later diagnosis is associated with improved 1-year survival. These benchmark data and identified prognostic factors may aid future evaluations of the impact of pulse oximetry screening on survival from CCHDs.
Nature vs nurture: Are leaders born or made? A behavior genetic investigation of leadership style

Abstract With the recent resurgence in popularity of trait theories of leadership, it is timely to consider the genetic determination of the multiple factors comprising the leadership construct. Individual differences in personality traits have been found to be moderately to highly heritable, and so it follows that if there are reliable personality trait differences between leaders and non-leaders, then there may be a heritable component to these individual differences. Despite this connection between leadership and personality traits, however, there are no studies of the genetic basis of leadership using modern behavior genetic methodology. The present study proposes to address the lack of research in this area by examining the heritability of leadership style, as measured by self-report psychometric inventories. The Multifactor Leadership Questionnaire (MLQ), the Leadership Ability Evaluation, and the Adjective Checklist were completed by 247 adult twin pairs (183 monozygotic and 64 same-sex dizygotic). Results indicated that most of the leadership dimensions examined in this study are heritable, as are two higher level factors (resembling transactional and transformational leadership)derived from anobliquely rotated principal components factors analysis of the MLQ. Univariate analyses suggested that 48% of the variance in transactional leadership may be explained by additive heritability, and 59% of the variance in transformational leadership may be explained by non-additive (dominance) heritability. Multi-variate analyses indicatedthat most ofthe variables studiedshared substantial genetic covariance, suggesting a large overlap in the underlying genes responsible for the leadership dimensions.
Army personnel satisfaction in different settings of primary health care clinics.

PURPOSE To analyze patient satisfaction in Israeli Defense Forces primary care clinics (PCCs), and to compare different satisfaction indices that best correlate with general satisfaction index. METHODS Large-scale patient satisfaction survey throughout all PCCs, classified as active front clinics, training schools clinics, and home front clinics. RESULTS Participants (5,103) filled out standardized questionnaires. Patients in active front clinics were more satisfied with their PCCs than in the other two settings. Patients showed the highest satisfaction level in the environment questions and the lowest satisfaction level in the accessibility questions. In training school clinics and home front clinics, accessibility questions were most important, whereas in active front clinics, health outcome questions prevailed. CONCLUSIONS Overall patient satisfaction is the highest in active front clinics, lower in training school clinics, and lowest in home front clinics. Accessibility is the most important factor in patient satisfaction in training school and home front units, and is less important in active front units.
Relationship between propagule pressure and colonization pressure in invasion ecology: a test with ships' ballast

Increasing empirical evidence indicates the number of released individuals (i.e. propagule pressure) and number of released species (i.e. colonization pressure) are key determinants of the number of species that successfully invade new habitats. In view of these relationships, and the possibility that ships transport whole communities of organisms, we collected 333 ballast water and sediment samples to investigate the relationship between propagule and colonization pressure for a variety of diverse taxonomic groups (diatoms, dinoflagellates and invertebrates). We also reviewed the scientific literature to compare the number of species transported by ships to those reported in nature. Here, we show that even though ships transport nearly entire local communities, a strong relationship between propagule and colonization pressure exists only for dinoflagellates. Our study provides evidence that colonization pressure of invertebrates and diatoms may fluctuate widely irrespective of propagule pressure. We suggest that the lack of correspondence is explained by reduced uptake of invertebrates into the transport vector and the sensitivity of invertebrates and diatoms to selective pressures during transportation. Selection during transportation is initially evident through decreases in propagule pressure, followed by decreased colonization pressure in the most sensitive taxa.