Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of the MEK/MAPK signal transduction pathway strongly impairs the growth of Flt3‐ITD cells

Letters and correspondence submitted for possible publication must be identified as such. Text length must not exceed 500 words and five bibliographic references. A single concise figure or table may be included if it is essential to support the communication. Letters not typed double-spaced will not be considered for publication. Letters not meeting these specifications will not be returned to authors. Letters to the Editor are utilized to communicate a single novel observation or finding. Correspondence is to be used to supplement or constructively comment on the contents of a publication in the journal and cannot exceed the restrictions for Letters to the Editor. The Editor reserves the right to shorten text, delete objectional comments, and make other changes to comply with the style of the journal. Permission for publication must be appended as a postscript. Submissions must be sent to Jay Umbreit, MD, PhD, Editor of Brief Reports/Letters to Editors, American Journal of Hematology, Winship Cancer Institute, Emory University, 1365-B Clifton Road, Suite B4100, Atlanta, GA 30322 to permit rapid consideration for publication.
Composition, Collimation, Contamination: The Jet of Cygnus X-1

We model the observed size and brightness of the VLBA radio core of the jet in Cygnus X-1 to derive an expression for the jet power as a function of basic jet parameters. We apply this expression to recent constraints on the jet power from observations of a large-scale shocked shell around the source by Gallo and coworkers, which leads us to a set of alternative conclusions: either (1) the jet contains large amounts of protons (≥2000 protons per radio-emitting electron), (2) it has a very low volume filling factor of f ≲ 3 × 10-5, (3) the steady, radio-emitting VLBA jet is not the source of the kinetic energy powering the ISM shell, or (4) its asymptotic behavior differs fundamentally from a broad set of plausible analytic jet models.
CASEWORKER INCREASE JOB PLACEMENTS

This paper examines whether the chances of job placements improve if unemployed persons are counselled by caseworkers who belong to the same social group, defined by gender, age, education, and nationality. Based on an unusually informative dataset, which links Swiss unemployed to their caseworkers, we find positive employment effects of about 4 percentage points if caseworker and unemployed belong to the same social group. Coincidence in a single characteristic, e.g. same gender of caseworker and unemployed, does not lead to detectable effects on employment. These results, obtained by statistical matching methods, are confirmed by several robustness checks.
Promoção de vendas: uma análise dos fatores influenciadores da intenção de compra de um produto em desconto

Resumo : a pesquisa se propos a avaliar o efeito da promocao de vendas de desconto sobre a intencao de compra. Pretendeu investigar como os comportamentos associados a atratividade da campanha, impulsividade, percepcao hedonica e risco financeiro se relacionam com o produto com desconto. Foi realizado um experimento de laboratorio junto a seiscentos e setenta alunos de graduacao do curso de administracao de empresas de uma Instituicao de Ensino Superior localizada no sul do Brasil. Os resultados apresentaram influencia significativa da promocao de desconto sobre a intencao de compra do consumidor. Ademais, foram detectadas influencias positivas e significativas da atratividade da promocao sobre a intencao de compra do produto em desconto, assim como uma relacao entre impulsividade e percepcao hedonica sobre o bem ofertado. Como esperado, encontrou-se, ainda, relacao negativa entre a percepcao de risco financeiro e a intencao de compra.
Proactive Control of Emotional Distraction: An ERP Investigation

According to the Dual Mechanisms of Control (DMC) framework (Braver, 2012) distraction can be controlled either proactively (i.e., before the onset of a distractor) or reactively (i.e., after the onset of a distractor). Research clearly indicates that, when distractors are emotionally neutral, proactive mechanisms are more effective at controlling distraction than reactive mechanisms. However, whether proactive control mechanisms can control irrelevant emotional distractions as effectively as neutral distraction is not known. In the current thesis I examined cognitive control over emotional distraction. In Experiment 1, I tested whether proactive mechanisms can control emotional distraction as effectively as neutral distraction. Participants completed a distraction task. On each trial, they determined whether a centrally presented target letter (embedded amongst a circle of ‘o’s) was an ‘X’ or an ‘N’, while ignoring peripheral distractors (negative, neutral, or positive images). Distractors were presented on either a low proportion (25%) or a high proportion (75%) of trials, to evoke reactive and proactive cognitive control strategies, respectively. Emotional images (both positive and negative) produced more distraction than neutral images in the low distractor frequency (i.e., reactive control) condition. Critically, emotional distraction was almost abolished in the high distractor frequency condition; emotional images were only slightly more distracting than neutral images, suggesting that proactive mechanisms can control emotional distraction almost as effectively as neutral distraction. In Experiment 2, I replicated and extended Experiment 1. ERPs were recorded while participants completed the distraction task. An early index (the early posterior negativity; EPN) and a late index (the late positive potential; LPP) of emotional processing were examined to investigate the mechanisms by which proactive control minimises emotional distraction. The behavioural results of Experiment 2 replicated Experiment 1, providing further support for the hypothesis that proactive mechanisms can control emotional distractions as effectively as neutral distractions. While proactive control was found to eliminate early emotional processing of positive distractors, it paradoxically did not attenuate late emotional processing of positive distractors. On the other hand, proactive control eliminated late emotional processing of negative distractors. However, the early index of emotional processing was not a reliable index of negative distractor processing under either reactive or proactive conditions. Taken together, my findings show that proactive mechanisms can effectively control emotional distraction, but do not clearly establish the mechanisms by which this occurs.
Marked Variability in Susceptibility to Ventricular Fibrillation in an Experimental Commotio Cordis Model

Background— Precordial blows in sports and daily activities can trigger ventricular fibrillation (VF) (commotio cordis). Whereas chest wall blows are common, commotio cordis is rare. Although factors such as timing, location, orientation, and energy of impact are critically important, we also hypothesize that there is individual susceptibility to commotio cordis. Using our model of commotio cordis, we evaluated individual animal susceptibility to VF induction and assessed animal characteristics that might be involved. Methods and Results— This retrospective analysis included 139 juvenile swine (weight, 8 to 54 kg) that were anesthetized and placed prone in a sling to receive chest wall strikes with a ball propelled at 30 to 40 mph. Each animal received a minimum of 4 impacts directly over the cardiac silhouette, all timed to a narrow vulnerable window during cardiac repolarization. Of 1274 total impacts, 360 impacts (28%) resulted in VF. There was wide variability in individual animal susceptibility to VF. In 38 animals, none of the impacts resulted in VF (range, 4 to 18 impacts per animal). The majority of animals (91; 65%) were induced into VF with <30% of the strikes. In fact, only 19 animals (14%) had >50% occurrence of VF with chest wall impacts, and only 7 (5%) had >80% occurrence of chest impacts that induced VF. In the animal-based analysis, individual correlates of VF included animal weight, mean impact velocity, mean left ventricular pressure generated by the blow, mean QRS duration, mean QTc, and QTc variability. In multivariable analysis, mean left ventricular pressure generated by the blow, mean QRS duration, and QTc variability remained significant correlates of risk, and number of impacts gained statistical significance such that animals with more impacts were less susceptible to VF. Conclusions— Swine display a wide range of individual vulnerability to VF triggered by chest wall impact, with a distinct minority being uniquely susceptible. Mild abnormalities in cardiac depolarization and repolarization might underlie this susceptibility. Such individual susceptibility may also be present in humans and contribute to the rarity of commotio cordis.
Thin Film Embedded Resistors

Resistors embedded in a printed wiring board will be an enabler for miniaturizing packages with higher reliability and improved electrical performance. Integrating the resistor functionality into the laminate substrate frees up the PWB surface area consumed by discrete components, enabling increased device functionality by the placement of more active components. Nickel-chromium alloys possess high electrical resistivity, which make them practical for use in a variety of applications. Nickel and chromium are alloyed with silicon and aluminum to improve temperature stability and lower the thermal coefficient of resistance. A thin film resistive layer based on nickel-chromium alloys has been deposited continuously onto rolls of copper foil to create a material for embedded resistor applications. The thin film resistive layer sandwiched between copper and laminate can be selectively etched to form discrete resistors. The chemicals for etching are common in PWB production processes. By controlling the thickness of the alloys, sheet resistance values from 25 to 250 ohm/sq. are obtained. This paper will compare two nickel-chromium materials in their etching methodologies, uniformity, power handling, thermal performance, adhesion and etching resolution.
Manejo electivo de los aneurismas de circulación anterior mediante abordaje pterional-basal

RESUMEN: Durante los últimos tres años hemos utilizado la vía pterional basal en 26 aneurismas de la circulación anterior cerebral. El abordaje consiste en una craneotomía pterional clásica realizada en un solo bloque con el complejo orbitocigomático, resección de las paredes orbitarias superior y lateral y clinioidectomia anterior. Esta técnica ofrece ventajas tales como abordajee multidireccional al aneurisma, poca retracción cerebral y menos morbilidad postoperatoria. Recomendamos este abordaje para la mayoría de aneurismas de circualación anterior, sobre todo los realizados en cirugía temprana y para los localizados en situación paraclinoidea.
The Problem of Juvenile Crime and the Making of Criminal Law in Finland, 1862–1889

This article describes procedures leading to the establishing of the Finnish Criminal Law of 1889 and, more particularly, discusses the changing interpretations of and societal reactions to juvenile crime as part of governing the minors. Legislation—including a specific understanding of juvenile crime as moral depravity—was finally provided as the interplay between the different mechanisms of social activity. Legislation was passed through when the conditions on all the essential levels of historical time turned favorable, forming a certain type of complex in governing juvenile crime.
iTrace: enabling eye tracking on software artifacts within the IDE to support software engineering tasks

The paper presents iTrace, an Eclipse plugin that implicitly records developers' eye movements while they work on change tasks. iTrace is the first eye tracking environment that makes it possible for researchers to conduct eye tracking studies on large software systems. An overview of the design and architecture is presented along with features and usage scenarios. iTrace is designed to support a variety of eye trackers. The design is flexible enough to record eye movements on various types of software artifacts (Java code, text/html/xml documents, diagrams), as well as IDE user interface elements. The plugin has been successfully used for software traceability tasks and program comprehension tasks. iTrace is also applicable to other tasks such as code summarization and code recommendations based on developer eye movements. A short video demonstration is available at https://youtu.be/3OUnLCX4dXo.
A Study on the Relationship of English Listening Comprehension to Linguistic, Cognitive and Affective Variables among Taiwanese Elementary School Students

The present study intended to take a close look at the relationship of Taiwanese young learners’ English listening comprehension to three clusters of variables —linguistic (general English proficiency and English vocabulary knowledge), cognitive, (Chinese listening ability and metacognitive awareness), and affective (English listening anxiety and language learning motivation). The participants of the present study were 141 sixth graders from two schools in Taipei City and New Taipei City. The instruments used in this study were: (1) an English listening comprehension test, (2) an English proficiency test, (3) a Chinese listening comprehension test, (4) an English vocabulary test, (5) a metacognitive awareness questionnaire, (6) an FL listening anxiety scale, and (7) a motivation questionnaire. The collected data were analyzed mainly through multiple regression analysis procedures. The major findings were summarized as follows. First, the three clusters of variables together significantly contributed to English listening comprehension (R 2 = .39, F(6, 134) = 14.15, p < . 001). Second, the cognitive variables significantly provided a unique (9%) explained variance (R 2 change = .09, F change (2,136) = 7.76, p < . 01) in English listening performance after the affective variables had been accounted for. Finally, the linguistic variables also significantly provided an additional (18%) explained variance (R 2 change = .18, F change (2,134) = 19.44, p < . 001) in English listening performance over and beyond the prediction afforded by the affective and cognitive variables. Based on the findings of the present study, some implications and recommendations for future research were provided.
Group II introns designed to insert into therapeutically relevant DNA target sites in human cells.

Mobile group II intron RNAs insert directly into DNA target sites and are then reverse-transcribed into genomic DNA by the associated intron-encoded protein. Target site recognition involves modifiable base-pairing interactions between the intron RNA and a >14-nucleotide region of the DNA target site, as well as fixed interactions between the protein and flanking regions. Here, we developed a highly efficient Escherichia coli genetic assay to determine detailed target site recognition rules for the Lactococcus lactis group II intron Ll.LtrB and to select introns that insert into desired target sites. Using human immunodeficiency virus-type 1 (HIV-1) proviral DNA and the human CCR5 gene as examples, we show that group II introns can be retargeted to insert efficiently into virtually any target DNA and that the retargeted introns retain activity in human cells. This work provides the practical basis for potential applications of targeted group II introns in genetic engineering, functional genomics, and gene therapy.
A random mutation capture assay to detect genomic point mutations in mouse tissue

Herein, a detailed protocol for a random mutation capture (RMC) assay to measure nuclear point mutation frequency in mouse tissue is described. This protocol is a simplified version of the original method developed for human tissue that is easier to perform, yet retains a high sensitivity of detection. In contrast to assays relying on phenotypic selection of reporter genes in transgenic mice, the RMC assay allows direct detection of mutations in endogenous genes in any mouse strain. Measuring mutation frequency within an intron of a transcribed gene, we show this assay to be highly reproducible. We analyzed mutation frequencies from the liver tissue of animals with a mutation within the intrinsic exonuclease domains of the two major DNA polymerases, δ and ε. These mice exhibited significantly higher mutation frequencies than did wild-type animals. A comparison with a previous analysis of these genotypes in Big Blue mice revealed the RMC assay to be more sensitive than the Big Blue assay for this application. As RMC does not require analysis of a particular gene, simultaneous analysis of mutation frequency at multiple genetic loci is feasible. This assay provides a versatile alternative to transgenic mouse models for the study of mutagenesis in vivo.
Situation management in crisis scenarios based on self-organizing neural mapping technology

During crisis situations decision makers are severely limited in their ability to consider system-wide conditions, predict changes in conditions, and access relevant expert knowledge and opinions. Useful information and knowledge are likely to be highly unstructured and widely dispersed. In this paper we describe an approach and accompanying algorithms that enable relationships to be developed and conclusions to be drawn from unstructured data obtained from disparate sources and stakeholders. The approach transforms Ars Cognita's existing self-organizing neural mapping technology from a passive knowledge acquisition and delivery system to an active system that can predict outcomes based upon the relationships inherent in its collected knowledge
Neuro-Behçet Disease and Autoinflammatory Disorders

Abstract Misregulation of innate immunity leads to autoinflammation. Behçet disease is an autoinflammatory condition involving recurrent attacks of inflammation in skin, eyes, joints, and even the nervous system. The etiology may involve vascular inflammation. Central nervous system involvement in neuro-Behçet disease (NBD) comes in the form of parenchymal NBD or nonparenchymal NBD. The parenchymal form has a predilection for the brainstem, diencephalon and cerebral hemispheres, and represents a meningoencephalitis thought to be related to small vessel vasculitis. Cerebral venous sinus thrombosis, arising from a vasculitic process of large veins, comprises the majority of vascular NBD cases. The rarer monogenetic autoinflammatory syndromes are characterized by periodic fever, and typically present in the pediatric population. Neurologic involvement in these syndromes typically presents in the form of an aseptic meningitis. Treatment of autoinflammatory disorders involves immune modulation with corticosteroids, disease-modifying antirheumatic medications, and increasingly antibodies targeting cytokines like tumor necrosis factor α and interleukin 1.
The Neuropsychological Assessment of Age Related Cognitive Deficits in Adults with Down's Syndrome

There is substantial evidence that older adults who have Down's syndrome are at risk for developing Alzheimer's disease. However, whilst the neuropathological signs of Alzheimer's disease are almost always apparent in those over the age of 30, the clinical signs may not be evident. This may be because the neuropathological changes are not sufficiently advanced to impair performance or because detecting neuropsychological deficits is more difficult in the presence of substantial, global cognitive impairment. In this study, 70 adults with Down's syndrome were assessed using a battery of neuropsychological tests, some of which had been used to assess dementia arising from Alzheimer's disease in the general population. Participants were screened to rule out advanced dementia or a pre-existing degree of cognitive impairment which would preclude participation in the tests. Analysis of test results for those under the age of 40, showed significant negative correlations between the Vineland Adaptive Behavior Scales and performance on all neuropsychological tests, thus demonstrating the effect of pre-existing global cognitive impairment on these particular tests. The results of a cross-sectional age group comparison, showed no difference between age groups on neuropsychological deficits which may indicate advanced dementia. This was almost certainly due to the screening procedure. However, the older age groups showed significantly impaired performance on memory tests in comparison to the younger age group. It is concluded that the more subtle cognitive impairments which associate to Alzheimer's disease can be identified in the presence of a global cognitive impairment with sufficiently sensitive tests.
Vaccination of adolescents with chronic medical conditions: Special considerations and strategies for enhancing uptake

Adolescents with chronic medical conditions (CMCs), a growing population worldwide, possess a wide array of preventive health care needs. Vaccination is strongly recommended for the vast majority of these adolescents given their increased risk of vaccine preventable infection and associated complications. Not only should they receive routine vaccines, but some also require additional vaccines. Despite these guidelines, evidence suggests that adolescents with CMCs often fail to receive needed vaccines. Many factors contribute to this under-immunization, including lack of knowledge among parents and providers and suboptimal coordination of primary and subspecialty care. This review describes current vaccination recommendations for these adolescents as well as recent data related to infection risk, vaccine efficacy and safety, vaccination coverage, and the unique multilevel factors impacting uptake in this population. It also discusses strategies for improving coverage levels and reducing missed vaccination opportunities, with a particular focus on technology-based interventions.
Branding of Flemish higher education institutions: a strategic balance perspective

Branding of higher education institutions (HEIs) is an expanding area of research. The existing literature mainly draws on the strategic management perspective that argues that HEIs are pressured to develop brands which differentiate them from their competitors. Past studies, however, do insufficiently take into account that most HEIs are positioned in systems that contain both competitive pressures (to differentiate) and institutional pressures (to meet taken-for-granted expectations), where neither of the pressures is clearly dominant. Our multiple case study of the five Flemish universities finds that branding can simultaneously address competitive and institutional pressures and that the universities studied combine aspects of distinctiveness with elements of similarity.
in Future Prospective in Engineering and Management Technology

Today Security of data is of foremost importance in today&apos;s world. Security has become one of the most important factor in communication and information technology. For this purpose steganography is used. Steganography is the art of hiding secret or sensitive information into digital media like images so as to have secure communication. In this paper we present and discuss LSB (Least Significant Bit) based image steganography and AES