Miracle-dz/UniFAR-FTUs huggingface dataset:
Expected Performance and Perceived Exertion in a Prolonged Physical Task

A prolonged bicycle ergometer task at a fixed sub-maximal intensity was carried out under three experimental conditions, varying in terms of the amount of feedback about performance provided to subjects. Using a repeated-measures methodology, subjects were asked every 3 min. to rate their perceived exertion and to estimate their expected performance level. The data indicated that these two measures were highly correlated when no feedback was given. However, when feedback about performance was given, the expected performance level was accordingly adjusted whereas the measure of perceived exertion remained unchanged. These data were interpreted as indicating that perceived exertion was based on physiological processes whereas the measure of expected performance was largely based on a cognitive-anticipatory process. The temporal course of relationships between the level of perceived exertion and heart rate indicated that, whereas the two measures were initially related, this relationship disappeared after heart rate had reached its steady state level. These data suggest that physiological processes other than heart rate have become the source of exertion perceptions.
Debunking the Stereotype

Much attention has been devoted in the past several years to public incidents of mass murder. Events such as the shooting on a Long Island commuter train in 1993, the massacre in Luby's Cafeteria in Killeen, Texas, in 1991, or the seemingly numerous workplace homicides have received intensive media coverage and public interest. As a consequence, a stereotype of mass murder has emerged that may or may not be very accurate. This study examines incidents of mass murder that occurred in public settings in the United States between 1965 and 1995 to more closely scrutinize both the events and the offenders involved.
Cultivating Carrots and Community: Local Organic Food and Sustainable Consumption

This paper examines the social implications of sustainable consumption through an empirical study of a local organic food initiative. It sets out an analytical framework based upon Douglas's Cultural Theory to categorise the range of competing value perspectives on sustainable consumption into ‘hierarchical', ‘individualistic’ and ‘egalitarian’ worldviews, and considers how these various worldviews might each adopt locally-grown organic food as a sustainable consumption initiative. Tensions between the paradigms are evident when attention is turned to a case study of a local organic food producers’ cooperative. Research with both producers and consumers reveals that the values embedded in its practice are both partisan and pluralistic, but are principally ‘Egalitarian'. Its interactions with policy regimes and social and economic institutions are examined, to illustrate the value conflicts inherent, and understand the barriers it faces in operation and the institutional factors inhibiting the growth of grassroots ‘bottom-up’ sustainable food initiatives of this kind. In addition to addressing these barriers, the policy implications of these findings for sustainable consumption policy and practice are discussed.
An integrative model of safety climate: Linking psychological climate and work attitudes to individual safety outcomes using meta-analysis.

Meta-analytic path analysis was utilised to test an integrative model linking perceived safety climate to hypothesized organisational antecedents and individual outcomes. Psychological climate, especially the perception of organisational attributes, was found to be significantly associated with safety climate (both constructs measured at the individual level). A partial mediation model was supported. Within this model, the relationship between safety climate and safety behaviour was partially mediated by work-related attitudes (organisational commitment and job satisfaction), and the relationship between safety climate and occupational accidents was partially mediated by both safety behaviour and general health. Safety climate acted as a partial mediator in the relationship between psychological climate and safety behaviour, with direct effects from climate perceptions relating to the leader and organisational processes. Avenues for further research and practical implications are discussed.
Cognitive behaviour therapy with a woman in her twenties with a mild intellectual disability presenting with psychogenic non‐epileptic seizures

Purpose – This case report aims to describe the treatment of a woman (Rachel) in her twenties who was referred to the community team for people with an intellectual disability by her neurologist as she wanted help with reducing the frequency of psychogenic non‐epileptic seizures (PNES). Design/methodology/approach – CBT was used as the therapeutic approach. The first stage of intervention focussed on reducing the frequency of PNES through relaxation and distraction techniques. Graded exposure was then used to enable Rachel to achieve her goal of going on the bus alone. The intervention process was completed over 12 sessions.Findings – Outcome was measured using self‐report of seizure frequency. Rachel has successfully reduced the frequency of PNES from seven to two‐three per week, and has managed to successfully complete several bus journeys on her own, working through the hierarchy the authors had developed. The authors also completed pre and post therapy measures for anxiety and depression. Her scores on.
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

Anti-MicroRNA Antiviral MicroRNAs (miRNAs) are small noncoding RNAs found in eukaryotes and viruses. They are critical regulators of a wide range of cellular processes. The highly conserved miRNA miR-122 is required for infection by hepatitis C virus (HCV), a leading cause of liver disease in humans. Present HCV treatment regimes can have serious side effects and are effective in only 50% of cases. In order to try to tackle HCV infection, Lanford et al. (p. 198, published online 3 December) targeted miR-122 using a complementary locked nucleic acid (LNA) oligonucleotide. Treatment of chimpanzees infected by HCV with the LNA antagonist resulted in a long-term reduction of disease symptoms without the concomitant appearance of resistant strains of the virus. Targeting a microRNA required for hepatitis C virus infection reduces disease symptoms in chimpanzees. The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for antiviral intervention has not been assessed. We found that treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)–modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia, with no evidence of viral resistance or side effects in the treated animals. Furthermore, transcriptome and histological analyses of liver biopsies demonstrated derepression of target mRNAs with miR-122 seed sites, down-regulation of interferon-regulated genes, and improvement of HCV-induced liver pathology. The prolonged virological response to SPC3649 treatment without HCV rebound holds promise of a new antiviral therapy with a high barrier to resistance.
Decision Affect Theory: Emotional Reactions to the Outcomes of Risky Options

How do people feel about the outcomes of risky options? Results from two experiments demonstrate that the emotional reaction to a monetary outcome is not a simple function of the utility of that outcome Emotional responses also depend on probabilities and unobtained outcomes Unexpected outcomes have greater emotional impact than expected outcomes Furthermore any given outcome is less pleasant if an unobtained outcome is better We propose an account of emotional experiences associated with outcomes of decisions called decision affect theory It incorporates utilities expectations and counterfactual comparisons into hedonic responses Finally we show that choices between risky options can be described as the maximization of expected emotional experiences as predicted by decision affect theory That is people choose the risky option for which they expect to feel better on average
Ultrasound detection and identification of cosmetic fillers in the skin

Background While the incidence of cosmetic filler injections is rising world‐wide, neither exact details of the procedure nor the agent used are always reported or remembered by the patients. Thus, although complications are reportedly rare, availability of a precise diagnostic tool to detect cutaneous filler deposits could help clarify the association between the procedure and the underlying pathology.
Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics

Stress stimuli can lead to remodeling of the actin cytoskeleton and subsequent alteration of cell adhesion and permeation as well as cell functions and cell fate. We investigated redox‐dependent Rho GTPase‐linked pathways controlling the actin cytoskeleton in the inner ear of the CBA mouse, by using aminoglycoside antibiotics as a noxious stimulus that causes loss of sensory cells via the formation of reactive oxygen species. Kanamycin treatment in vivo interfered with the formation of F‐actin, disturbed the arrangement of β‐actin in the stereocilia of outer hair cells, and altered the intermittent adherens junction/tight junction complexes between outer hair cells and supporting cells. The drug treatment also activated Rac1 and promoted the formation of the complex of Rac1 and p67phox while decreasing the activity of RhoA and reducing the formation of the RhoA/p140mDia complex. In inner‐ear‐derived cell lines, expression of mutated Rac1 changed the structural arrangement of F‐actin and diminished the immunoreactivity of p140mDia. These findings suggest that actin depolymerization induced by kanamycin is mediated by Rac1 activation, followed by the formation of superoxide by NADPH oxidase. These changes will ultimately contribute to aminoglycoside‐induced loss of hair cells. © 2006 Wiley‐Liss, Inc.
On Metamemory-Memory Relationship: Strategy Availability and Training

In the present study, a metamemory assessment procedure measuring a general level of metamemory was proposed. The procedure used a storyplot type of structure. On the basis of the metamemory score, different age group children were divided into high and low metamemory subgroups. In Experiment 1, the performance of high metamemory and low metamemory children differed significantly when the demand of the memory task fell within children's knowledge of memory, supporting the validity of the procedure. It did not differ in Experiment 2, when the memory task required the use of a more sophisticated strategy, where knowledge was not tapped through the metamemory task. Moreover, while telling children which strategy had to be used did not differentiate the performance of the two metamemory groups, giving children a practice training on the use of the strategy (Experiment 3) differentiated high and low metamemory children in terms of their ability to generalise the use of the strategy through a near-transfer memory task.
Family Learning in Museums: A Bibliographic Review.

The literature on family behavior in informal science settings consists primarily of observational studies of behavior, focusing on generation and gender roles and learning strategies. Much effort has been expended studying the family visit, building the foundation for further study. A question that remains is: Can we infer learning from observations of learning behavior among family members? The literature in this annotated bibliography addresses issues involved in understanding the family learning process — what a family is, why families visit museums, how they behave in museums, how they learn in museums, and measuring learning.
Scales and Tooth Whorls of Ancient Fishes Challenge Distinction between External and Oral ‘Teeth’

The debate about the origin of the vertebrate dentition has been given fresh fuel by new fossil discoveries and developmental studies of extant animals. Odontodes (teeth or tooth-like structures) can be found in two distinct regions, the ‘internal’ oropharyngeal cavity and the ‘external’ skin. A recent hypothesis argues that regularly patterned odontodes is a specific oropharyngeal feature, whereas odontodes in the external skeleton lack this organization. However, this argument relies on the skeletal system of modern chondrichthyans (sharks and their relatives), which differ from other gnathostome (jawed vertebrate) groups in not having dermal bones associated with the odontodes. Their external skeleton is also composed of monoodontode 'placoid scales', whereas the scales of most early fossil gnathostomes are polyodontode, i.e. constructed from several odontodes on a shared bony base. Propagation phase contrast X-ray Synchrotron microtomography (PPC-SRµCT) is used to study the polyodontode scales of the early bony fish Andreolepis hedei. The odontodes constructing a single scale are reconstructed in 3D, and a linear and regular growth mechanism similar to that in a gnathostome dentition is confirmed, together with a second, gap-filling growth mechanism. Acanthodian tooth whorls are described, which show that ossification of the whorl base preceded and probably patterned the development of the dental lamina, in contrast to the condition in sharks where the dental lamina develops early and patterns the dentition.The new findings reveal, for the first time, how polyodontode scales grow in 3D in an extinct bony fish. They show that dentition-like odontode patterning occurs on scales and that the primary patterning unit of a tooth whorl may be the bony base rather than the odontodes it carries. These results contradict the hypothesis that oropharyngeal and external odontode skeletons are fundamentally separate and suggest that the importance of dermal bone interactions to odontode patterning has been underestimated.
Joint Video Stitching and Stabilization From Moving Cameras

In this paper, we extend image stitching to video stitching for videos that are captured for the same scene simultaneously by multiple moving cameras. In practice, videos captured under this circumstance often appear shaky. Directly applying image stitching methods for shaking videos often suffers from strong spatial and temporal artifacts. To solve this problem, we propose a unified framework in which video stitching and stabilization are performed jointly. Specifically, our system takes several overlapping videos as inputs. We estimate both inter motions (between different videos) and intra motions (between neighboring frames within a video). Then, we solve an optimal virtual 2D camera path from all original paths. An enlarged field of view along the virtual path is finally obtained by a space-temporal optimization that takes both inter and intra motions into consideration. Two important components of this optimization are that: 1) a grid-based tracking method is designed for an improved robustness, which produces features that are distributed evenly within and across multiple views and 2) a mesh-based motion model is adopted for the handling of the scene parallax. Some experimental results are provided to demonstrate the effectiveness of our approach on various consumer-level videos and a Plugin, named “Video Stitcher” is developed at Adobe After Effects CC2015 to show the processed videos.
Hormone dependency of breast cancer

Quantitative determination of the estrogen receptor (estrophilin) content of an excised tumor specimen provides information useful in selecting the type of systemic therapy best suited to the individual patient with advanced breast cancer. Women whose tumors contain low or negligible amounts of estrophilin rarely respond to endocrine ablation or other hormone therapy, whereas most but not all patients with receptor‐rich cancers receive benefit from endocrine treatment. Properly interpreted, estrophilin assay predicts hormone dependency correctly in 85 to 90 percent of the cases. Analysis of the primary tumor at the time of mastectomy not only serves as a guide to subsequent therapy if metastases should appear but it also provides a clue to the probability and rapidity of recurrence. Because present methods for receptor determination have certain limitations, we are developing an immunoassay, based on monoclonal antibodies to human estrophilin, that promises to provide a simple, inexpensive procedure for the routine analysis of breast cancer specimens.
Research report: improving browsing in information by the automatic display layout

It is well known that graphical representations could be very helpful to browse in graph structured information. But this promising approach requires the capability of an automatic layout system because the tedious and time consuming task of a manual layout leads to a rejection of this approach by the user. In our approach, we split the task of retrieving information into two phases that are getting the orientation within the network and reading currently visited information. We present layout algorithms for both phases which have the benefit of being flexible and adaptable to individual user requests and ensure the topological consistency, i.e. the stability of the topology of the information layout during a sequence of display layouts. The results show that especially the possibility of an animation of the layout process can assist the user essentially in maintaining the orientation in the information network.
EBV‐negative lymphoproliferative disease with hyper‐IgA, in a child with combined liver and small bowel transplantation

Abstract: A 4‐year‐old boy presented 14 months after liver and small bowel transplantation with fever, diarrhea, elevated liver enzymes, thrombocytopenia and autoantibodies. Total gammaglobulins level was normal but the level of plasma IgA1 was very high. The blood PCR for Epstein–Barr virus (EBV) was negative. The ileal biopsy disclosed a lymphoplasmacytic infiltration. The EBER probe was negative on the small bowel biopsies. The child was considered as suffering from a non‐EBV‐induced posttransplant lymphoproliferative disorder (PTLD). The high IgA level was presumed to be secreted by proliferating plasma cells in the transplanted bowel. Immunosuppression was reduced; but the efficacy was incomplete and an anti‐CD20 antibody was added. There was complete resolution of symptoms and normalization of the IgA level. As IgA1 is mostly of intestinal origin, this unusual presentation of PTLD should lead to a high suspicion of a small bowel proliferating process.
[Tapentadol prolonged release improves analgesia, functional impairment and quality of life in patients with chronic pain who have previously received oxycodone/naloxone].

STUDY OBJECTIVE This subgroup analysis of a prospective, non-interventional study involving general practitioners and internists investigated the administration of tapentadol prolonged release (tapentadol PR; Palexia retard) for the treatment of patients who have previously received oxycodone/naloxone. METHODS From the overall effectiveness sample (n = 5,002) data of all patients who were previously treated with oxycodone/naloxone in a fixed combination (n = 382) were included in this analysis. Data collection during the 3-month observation period included previous and concomitant analgesic treatment, tapentadol PR dosage, pain intensity, functional impairment, and tolerability of tapentadol PR. Health related quality of life was documented at baseline and at the end of observation by patients using the SF-12 questionnaire. RESULTS Back pain was the most common cause of pain. Including all pain diagnoses, mixed type of pain (nociceptive and neuropathic) predominated. The oxycodone/naloxone pretreatment was multifold combined with strong opioids (10.2%), weak opioids (29.3%), non- opioids (78.3%), co-analgesics (56.0%) and analgesic rescue medication (26.9%). Switching to tapentadol PR resulted in a mean pain reduction of 3.41 points from 7.29 ± 1.40 at baseline to 3.88 ± 1.86 at end of observation (NRS 11, 11-point pain scale; descriptive p value ≤ 0.001; n = 373), using a final average daily dosage of 252.9 mg tapentadol PR. In all four categories assessing the pain-related functional impairment, significant improvements have been achieved. In addition to significantly reduced pain-related impairments of everyday activities patients' data documented significant improvements in physical and mental SF-12 total scores, which initially were already at critically low range. A good tolerability of tapentadol PR therapy was reported. CONCLUSIONS Patients, who were previously treated with oxycodone/naloxone, benefit from a tapentadol PR therapy as well: data analysis shows a clinically relevant improvement of analgesia, functionality and quality of life. Furthermore, the previous analgesic "co"-medication could be reduced during tapentadol PR therapy.
Using Natural Language Policies for Privacy Control in Social Platforms

De Coi, J. L. , Karger, P., Olmedilla, D. , & Zerr, S. (2009). Using Natural Language Policies for Privacy Control in Social Platforms. In M. Hausenblas, P. Karger, D. Olmedilla, A. Passant & A. Polleres (Eds.), Proceedings of the First Workshop on Trust and Privacy on the Social and Semantic Web (SPOT2009). June, 1, 2009, Heraklion, Greece: CEUR Workshop Proceedings, ISSN 1613-0073. Available online: CEUR-WS.org/Vol-447/.
Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound

A noninvasive technique for monitoring tissue temperature changes due to heating fields using diagnostic ultrasound is described. The approach is based on the discrete scattering model used in the tissue characterization literature and the observation that most biological tissues are semi-regular scattering lattices. It has been demonstrated by many researchers and verified by the authors that the spectrum of the backscattered radio frequency (RF) signal collected with a diagnostic ultrasound transducer from a semi-regular tissue sample exhibits harmonically related resonances at frequencies determined by the average spacing between scatterers along a segment of the A-line. It is shown theoretically and demonstrated experimentally (for phantom, in vitro, and in vivo media) that these resonances change with changes in the tissue temperature within the processing window. In fact, changes in the resonances (/spl Delta/f) are linearly proportional to changes in the temperature (/spl Delta/T), with the proportionality constant being determined by changes in the speed of sound with temperature and the linear coefficient of thermal expansion of the tissue. Autoregressive (AR) model-based methods aid in the estimation of /spl Delta/f. It should be emphasized that this new technique is not a time of flight velocimetric one, so it represents a departure from previously used ultrasonic methods for tissue temperature estimation. <<ETX>>