Miracle-dz/UniFAR-FTUs huggingface dataset:
Machine-Based Morphologic Analysis of Glioblastoma Using Whole-Slide Pathology Images Uncovers Clinically Relevant Molecular Correlates

Pathologic review of tumor morphology in histologic sections is the traditional method for cancer classification and grading, yet human review has limitations that can result in low reproducibility and inter-observer agreement. Computerized image analysis can partially overcome these shortcomings due to its capacity to quantitatively and reproducibly measure histologic structures on a large-scale. In this paper, we present an end-to-end image analysis and data integration pipeline for large-scale morphologic analysis of pathology images and demonstrate the ability to correlate phenotypic groups with molecular data and clinical outcomes. We demonstrate our method in the context of glioblastoma (GBM), with specific focus on the degree of the oligodendroglioma component. Over 200 million nuclei in digitized pathology slides from 117 GBMs in the Cancer Genome Atlas were quantitatively analyzed, followed by multiplatform correlation of nuclear features with molecular and clinical data. For each nucleus, a Nuclear Score (NS) was calculated based on the degree of oligodendroglioma appearance, using a regression model trained from the optimal feature set. Using the frequencies of neoplastic nuclei in low and high NS intervals, we were able to cluster patients into three well-separated disease groups that contained low, medium, or high Oligodendroglioma Component (OC). We showed that machine-based classification of GBMs with high oligodendroglioma component uncovered a set of tumors with strong associations with PDGFRA amplification, proneural transcriptional class, and expression of the oligodendrocyte signature genes MBP, HOXD1, PLP1, MOBP and PDGFRA. Quantitative morphologic features within the GBMs that correlated most strongly with oligodendrocyte gene expression were high nuclear circularity and low eccentricity. These findings highlight the potential of high throughput morphologic analysis to complement and inform human-based pathologic review.
Role of sipA in the early stages of Salmonella typhimurium entry into epithelial cells

Salmonella virulence depends on an ability to invade host cells, which is in turn dependent on a type III protein secretion system encoded in Salmonella pathogenicity island 1 (SPI1). Several protein targets of the SPI1‐encoded secretion system are translocated into host cells, where they subvert cellular processes that contribute to bacterial invasion, actin rearrangement, membrane ruffling and other aspects of virulence. We examined the role of sipA (encoding the translocated protein SipA) and found that a sipA mutant was significantly less invasive in Madin–Darby canine kidney (MDCK) cells than in its parental strain at the earliest stages of infection (5 min). The invasion defect associated with sipA was no longer apparent after 15 min of infection. Confocal microscopy of F‐actin in tetramethyl rhodamine isothiocyanate (TRITC)–phalloidin‐stained MDCK cells revealed no difference in either the frequency or the morphology of membrane ruffles induced by wild‐type and sipA mutant strains of S. typhimurium. Time‐lapse phase‐contrast microscopy of membrane ruffle propagation in live cells confirmed that the sipA mutant induced membrane ruffles as efficiently as the wild‐type bacteria. These studies also revealed that, after ruffle propagation, individual sipA mutant S. typhimurium either invaded more slowly than wild‐type bacteria or failed to invade at all. Furthermore, although wild‐type S. typhimurium typically maintained a position central to the developing membrane ruffle, sipA mutant bacteria frequently moved initially to the periphery of the spreading ruffle and were sometimes observed to detach from it. A wild‐type pattern of invasion was restored to the sipA mutant after the introduction of sipA on a plasmid. Together, these data indicate that loss of sipA significantly decreases the efficiency of S. typhimurium invasion at the early stages of infection without affecting its ability to induce membrane ruffles. It thus appears that the secreted effector protein SipA promotes invasion by a previously unrecognized mechanism separate from the induction of membrane ruffling per se.
Analyzing characteristics of PC cluster consolidated with IP-SAN using data-intensive applications

In the information society in recent years, the volume of data requested to process increases explosively. Information required from users should be extracted from it instantly. In order to process huge volumes of data, we have constructed a PC cluster consolidated with IP-SAN that integrates the front-end and the back-end networks into the same IP network. However, the detailed analysis is not yet performed how the communication between nodes of the cluster and the execution of I/O influence the behavior of the system performance, when data-intensive applications are executed on it. Thus, in this paper, a PC cluster consolidated with IPSAN is evaluated when the network and target of the cluster are burdened with a heavy load, by accessing a single target with multiple initiators. As an example of data-intensive applications, parallel association rule mining is executed. As the system is monitored and analized, detailed behavior of the PC cluster consolidated with IP-SAN is clarified.
Biological Activities of Toninia candida and Usnea barbata Together with Their Norstictic Acid and Usnic Acid Constituents

The aim of this study was to investigate the chemical composition of acetone extracts of the lichens Toninia candida and Usnea barbata and in vitro antioxidant, antimicrobial, and anticancer activities of these extracts together with some of their major metabolites. The chemical composition of T. candida and U. barbata extracts was determined using HPLC-UV analysis. The major phenolic compounds in these extracts were norstictic acid (T. candida) and usnic acid (U. barbata). Antioxidant activity was evaluated by free radical scavenging, superoxide anion radical scavenging, reducing power and determination of total phenolic compounds. Results of the study proved that norstictic acid had the largest antioxidant activity. The total content of phenols in the extracts was determined as the pyrocatechol equivalent. The antimicrobial activity was estimated by determination of the minimal inhibitory concentration using the broth microdilution method. The most active was usnic acid with minimum inhibitory concentration values ranging from 0.0008 to 0.5 mg/mL. Anticancer activity was tested against FemX (human melanoma) and LS174 (human colon carcinoma) cell lines using the microculture tetrazolium test. Usnic acid was found to have the strongest anticancer activity towards both cell lines with IC50 values of 12.72 and 15.66 μg/mL.
SATISFACCIÓN RESIDENCIAL: UN CONCEPTO DE CALIDAD DE VIDA EN LA CIUDAD DE MONTREAL

El abandono de los sectores centrales y la incontrolable expansion de los perifericos enla ciudad de Montreal, es un fenomeno urbano de los siglos xx y xxi que atenta contra lasatisfaccion residencial y la calidad de vida local. Esta investigacion realiza una encuestaen el sector central de la ciudad para evaluar ese problema en terminos de la satisfaccion eimportancia residencial como indices subjetivo y objetivo de la calidad de vida (cvd) desdela perspectiva de un analisis de correlacion lineal (spss).
Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation

The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer, and potentially represent novel targets for diagnosis and therapy. In particular, functional genomic analysis of microRNA (miRNA) and long noncoding RNA (lncRNA) in cancer is likely to contribute insights into tumor development. Here, we compile recent efforts to catalog differential expression of miRNA and lncRNA in prostate cancer and to understand RNA function in tumor progression. We further highlight technologies for molecular characterization of noncoding RNAs and provide an overview of current activities to exploit them for the diagnosis and therapy of this complex tumor.
Sex Role Identity, Role Performance and Marital Satisfaction of Newly-Wed Couples

This research examined sex role identity as a mediator of marital role performance and satisfaction in early marriage. Sex role identity (indexed by the Bem Sex Role Inventory), performance of instrumental and expressive marital roles, and marital satisfaction were assessed among 110 newly married couples. Results confirmed hypothesized congruence of sex role identity and instrumental role performance among men, but not women. Similar effects emerged for perceived segregation of marital roles. Sex role identity predicted marital satisfaction of both spouses; in general, feminine men and masculine women expressed greater satisfaction. Men appeared more satisfied if married to masculine women; wives' satisfaction was, however, independent of their husbands' sex role identities. Marital satisfaction was also positively related to mutuality of expressive behaviour and negatively to perceived segregation of expressive roles. Results were discussed in terms of sex differences in marital values and process. Divergence from previous research findings is attributed to possible developmental trends within marital relationships.
Dynamic state estimation using particle filter and adaptive vector quantizer

Particle filter (PF) is a method for discrete approximation of dynamic and non-Gaussian probability distribution by using numerous particles, and its procedure can execute at high speed and is suitable for on-line applications. However, in conventional methods, a weighted average value or a maximum weighted value of particles is used as a filter output, and information on most particles is disregarded. On the other hand, an adaptive vector quantization (AVQ) algorithm called competitive reinitialization learning (CRL) that can achieve high-speed adaptation without depending on initial conditions has been proposed. Then, in this research, a method for extracting information on shape of probability density distributions by combining PF with CRL is proposed. Moreover, a rapid adaptation performance and the robustness of the proposed method are shown by the simulations.
Performance Study of Spindle, A Web Analytics Query Engine Implemented in Spark

This paper shares our experiences building and benchmarking Spindle as an open source Spark-based web analytics platform. Spindle's design has been motivated by real-world queries and data requiring concurrent, low latency query execution. We identify a search space of Spark tuning options and study their impact on Spark's performance. Results from a self-hosted six node cluster with one week of analytics data (13.1GB) indicate tuning options such as proper partitioning can cause a 5x performance improvement.
Prejudice and Group‐Related Behavior in Germany

This article analyses the relationship of ethnic prejudice and discriminatory behavioral intentions in Germany. We utilize two representative surveys conducted in 2002 and 2004 (N= 2,722 and 1,383, respectively) as well as a longitudinal study with three annual measurement points (2002–2004; N= 825). Results show that prejudice is substantially correlated with the respondents' reports of their own discriminatory intentions (R= .33 to .49). Controlling for additional psychological variables, the cross-lagged, longitudinal analyses support the causal hypothesis that prejudice leads to discriminatory intentions. Additional influences on discriminatory intentions—intergroup threat and intergroup contact—are substantially mediated by ethnic prejudice. Thus, a practical implication of these results is that the reduction of intergroup threat and increment of intergroup contact may well lead to both reduced intergroup prejudice and to less discriminatory behavior.
Cultivating “Japanese Who Can Use English”: Problems and Contradictions in Government Policy

In 2003 the Japanese government announced a 5-year plan to educate Japanese youth to be able to use English in the workplace. The idea originated from a proposal to adopt ‘‘English as an official language’’ in the government’s vision for the twenty-first century that was formulated in 2000 (Prime Minister’s Commission on Japan’s Goals in the 21 Century). In July 2002, the Ministry of Education, Culture, Science, Sports and Technology (MEXT) released a document entitled ‘Developing a Strategic Plan to Cultivate ‘‘Japanese with English Abilities’’’ (hereafter SPJE 2002), followed by another document, ‘Regarding the Establishment of an Action Plan to Cultivate ‘‘Japanese with English Abilities’’’ (hereafter APJE 2003), which was published in March 2003. The expression ‘‘Japanese with English abilities’’ is used in the official English versions of both the strategic plan and the action plan. The original Japanese [eigo ga tsukaeru nihonjin], however, is a rather informal expression that literally means ‘‘Japanese who can use English’’, a phrase that has been widely used since the release of the strategic plan. The plan to cultivate ‘‘Japanese who can use English’’ reflects the current situation surrounding TEFL (Teaching of English as a Foreign Language) in many ways. This article will examine the policy texts of the plans and other related documents, and argue that the texts themselves embody problems and contradictions in the government’s attempt to promote English as a means of boosting the economy. These two policy texts are products of the necessary compromise between the maintenance of Japan’s cultural independence and the promotion of English as an indispensable tool for international market competitiveness. I will also demonstrate that there is rhetorical continuity between the policy texts and public discourse, which indicates that the Japanese government’s agenda of maintaining cultural independence in an era of
Quantification of diagnostic accuracy using nitrate enhanced Tc-99m sestamibi gated myocardial SPECT in assessing myocardial viability: prospective analysis

The aim of this prospective study was to assess myocardial viability with nitrate-enhanced Tc-99m sestamibi gated single-photon emission computed tomography in patients with known coronary artery disease. We enrolled 48 consecutive patients (39 men, 9 women) aged 24–82 years, with coronary artery disease and history of myocardial infarction. A Tc-99m sestamibi study was conducted at rest as baseline, followed by a nitrate-enhanced study the next day. Of 960 segments analyzed, 244 of 480 in the left anterior descending coronary artery territory showed viability on the baseline study, and 276 were viable according to the nitrate-enhanced study. Similarly, of 192 right coronary segments analyzed, 148 showed viability on the baseline study compared to 153 on the nitrate study. Of 288 left circumflex territory segments analyzed, 206 showed viability on the baseline study compared to 241 on the nitrate study. The overall improvement of viability with the nitrate study was 12.04%. On the gated studies, the overall improvement with nitrate was 2.02%. The gated study also allowed grading of wall motion and thickness. It was concluded that nitrate-augmented Tc-99m sestamibi myocardial imaging significantly improved the detection of hibernating myocardium, with gated images further improving the accuracy of detection in borderline cases.
Mudpad: fluid haptics for multitouch surfaces

In this paper, we present an active haptic multitouch input device. Its touch surface is a malleable pouch filled with a smart fluid. The viscosity of this fluid can be controlled to provide localized active haptic feedback. Magnetic fields can stiffen the liquid locally, thus creating an invisible "labyrinth that can be felt when a user tries to displace the liquid at an activated location. The user feels this labyrinth as a relief when running her fingers over the surface. We believe there are promising applications for this kind of haptic feedback. Hence, we intend to further investigate them in comparison to traditional vibrotactile feedback techniques.
Sympathetic nerve stimulation activates both beta 1- and beta 2-adrenoceptors of SA and AV nodes in anesthetized dog hearts.

We investigated blocking effects of the selective beta 1-adrenoceptor blocker atenolol (0.1-100 micrograms/kg, i.v.), the selective beta 2-adrenoceptor blocker ICI 118,551 (1-1000 micrograms/kg, i.v.) and the combination of the two drugs on positive chronotropic and dromotropic responses to norepinephrine (NE) released by stimulation of the sympathetic nerves in anesthetized, neurally decentralized, open-chest dogs after atropine was given. Stimulation of the intracardiac sympathetic nerves to the SA nodal region or to the AV nodal region selectively increased heart rate or decreased AV conduction time, respectively. ICI 118,551 inhibited the chronotropic or dromotropic response to each stimulation in a dose-dependent manner, but its inhibition of the dromotropic response was less than that of the chronotropic response. Atenolol similarly inhibited either the positive chronotropic or dromotropic response to each stimulation in a dose-related manner. The combination of atenolol and ICI 118,551 attenuated the responses to each stimulation more than atenolol alone. These data indicate that sympathetic nerve stimulation activates both beta 1- and beta 2-adrenoceptors of the SA and AV nodes and that the proportion of beta 2-adrenoceptor-mediated effects on the AV node is less than that on the SA node. These results suggest that neurally released NE in part controls physiological functional cardiac responses mediated through beta 2-adrenoceptors, in addition to the responses predominantly mediated through beta 1-adrenoceptors.
Optimizing parallel join of column-stores on heterogeneous computing platforms

GPU and integrated multi-core CPU-GPU architecture has powerful parallel processing capability and programmable pipeline, which gradually becomes a hot area of database researches. In order to fully explore the potential abilities of heterogeneous platform, enhancing the query performance of the column-storage database. In this paper, we are taking full account of differences among system architecture based on heterogeneous platforms, firstly proposed data partition strategy for join operation on multi-thread platform-ICMD algorithm, using stream processor to process sub-space join operation in parallel. Secondly, through the implementation of query dynamic load by using task allocation model evaluation, which makes the query execution in parallel between multi-core CPU, GPU and other accelerator components. At the same time, the use of on-chip global synchronization and efficient implementation, local memory reuse optimized ICMD connection algorithm. Using SSB benchmark test, the experimental results show that based on the platform of Intel HD Graphics 4600, ICMD connection query received 1.35 speedup compared to the CPU version and received 18% performance improvement compared with GPU query engine-Ocelot.
Harmonic potential-based Communication-Aware Navigation of mobile agents in cluttered spaces

In this paper we propose a Communication-Aware Navigation (CAN) controller to safely guide an agent to a target position in a cluttered environment while maintaining a reliable Wireless Communication Link (WCL). The CAN controller is based on the Harmonic Potential Field (HPF) approach to motion planning. The navigator can generate a communication-aware navigation control signal that is able to safely steer an agent with non-trivial dynamics to a target point along a direct trajectory that avoids obstacles and Dead Communication Zones (DCZ). The approach is developed and basic proofs are provided. The capabilities of the method are demonstrated using simulation results.
Why content literacy is difficult to infuse into the secondary school: complexities of curriculum, pedagogy, and school culture

Le modele utilise pour faire entrer la lecture-ecriture dans les disciplines enseignees dans le secondaire se heurte a des resistances du fait que ses bases ont ete elaborees en dehors du contexte scolaire auquel il s'adresse. Les AA. defendent l'idee que les buts et les methodes des enseignements de lecture-ecriture dans les disciplines sont paradoxaux
Attractiveness and Corporate Success. Different Causal Attributions for Males and Females

To determine whether appearance influences how an individual's corporate success is explained, 113 working men and women were presented with the work history of an assistant vice president (AVP) of a midsized corporation who was an either attractive or unattractive male or female. Additionally, the AVP's rise to the senior ranks was depicted as either unusually rapid or normative in pace. Results indicated that, as predicted, attractiveness had different effects on the degree to which the AVP's success was attributed to ability depending upon whether the AVP was male or female; males' ability attributions were enhanced by their good looks and females' ability attributions were detrimentally affected by them. Also as expected, capability judgments followed a similar pattern. Appearance was additionally shown to have different consequences for males and females when likeability and interpersonal integrity were rated. However, contrary to predictions, the rapidity of corporate ascent did not interact with appearance or sex in affecting attributions about or impressions of the stimulus AVPs. The implications of these results, both conceptual and practical, are discussed. In recent years psychologists have begun to focus on physical appearance as a potentially biasing factor in personnel decision making. In several studies those who are attractive have been shown to be at an advantage when qualifications are assessed and when hiring decisions are made (Dipboye, Arvey, & Terpstra, 1977; Dipboye, Fromkin, & Wiback, 1975). These studies have lent support to the idea, so popular in the social psychology literature (Berscheid & Walster, 1974), that he or she who is beautiful is also better off. However, the effects of attractiveness have not been shown to be uniformly favorable. On the contrary, women who are attractive seem to be disadvantaged by their appearance when they apply for managerial positions (Heilman & Saruwatari, 1979) or other male sex-typed positions (Cash, Gillen, & Burns, 1977). Furthermore, this effect is not confined to selection decisions alone; attractiveness also has proven to be a distinct disadvantage for managerial women when their work is evaluated and recommendations for organi