Miracle-dz/UniFAR-FTUs huggingface dataset:
Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee

Improving diet and lifestyle is a critical component of the American Heart Association’s strategy for cardiovascular disease risk reduction in the general population. This document presents recommendations designed to meet this objective. Specific goals are to consume an overall healthy diet; aim for a healthy body weight; aim for recommended levels of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides; aim for normal blood pressure; aim for a normal blood glucose level; be physically active; and avoid use of and exposure to tobacco products. The recommendations are to balance caloric intake and physical activity to achieve and maintain a healthy body weight; consume a diet rich in vegetables and fruits; choose whole-grain, high-fiber foods; consume fish, especially oily fish, at least twice a week; limit intake of saturated fat to <7% of energy, trans fat to <1% of energy, and cholesterol to <300 mg/day by choosing lean meats and vegetable alternatives, fat-free (skim) or low-fat (1% fat) dairy products and minimize intake of partially hydrogenated fats; minimize intake of beverages and foods with added sugars; choose and prepare foods with little or no salt; if you consume alcohol, do so in moderation; and when you eat food prepared outside of the home, follow these Diet and Lifestyle Recommendations. By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States.
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer.

PURPOSE To investigate the efficacy and safety of bevacizumab plus carboplatin and paclitaxel in patients with advanced or recurrent non-small-cell lung cancer. PATIENTS AND METHODS In a phase II trial, 99 patients were randomly assigned to bevacizumab 7.5 (n = 32) or 15 mg/kg (n = 35) plus carboplatin (area under the curve = 6) and paclitaxel (200 mg/m(2)) every 3 weeks or carboplatin and paclitaxel alone (n = 32). Primary efficacy end points were time to disease progression and best confirmed response rate. On disease progression, patients in the control arm had the option to receive single-agent bevacizumab 15 mg/kg every 3 weeks. RESULTS Compared with the control arm, treatment with carboplatin and paclitaxel plus bevacizumab (15 mg/kg) resulted in a higher response rate (31.5% v 18.8%), longer median time to progression (7.4 v 4.2 months) and a modest increase in survival (17.7 v 14.9 months). Of the 19 control patients that crossed over to single-agent bevacizumab, five experienced stable disease, and 1-year survival was 47%. Bleeding was the most prominent adverse event and was manifested in two distinct clinical patterns; minor mucocutaneous hemorrhage and major hemoptysis. Major hemoptysis was associated with squamous cell histology, tumor necrosis and cavitation, and disease location close to major blood vessels. CONCLUSION Bevacizumab in combination with carboplatin and paclitaxel improved overall response and time to progression in patients with advanced or recurrent non-small-cell lung cancer. Patients with nonsquamous cell histology appear to be a subpopulation with improved outcome and acceptable safety risks.
Harnessing grid resources to enable the dynamic analysis of large astronomy datasets

Astronomy datasets are generally terabytes in size and contain hundreds of millions of objects separated into millions of files-factors which makes many analyses impractical to perform on small computers. The key question we answer in this paper is: "How can we leverage Grid resources to make the analysis of large astronomy datasets a reality for the astronomy community? " To address this question, we have developed a Web Services-based system, AstroPortal, that uses grid computing to federate large computing and storage resources for dynamic analysis of large datasets. Building on the GT4, we have built a prototype and implemented a first analysis, "stacking," that sums multiple regions of the sky, a function that can help both identify variable sources and detect faint objects. AstroPortal gives the astronomy community a new tool to advance their research and to open new doors to opportunities never before possible on such a large scale.
Can Vibrotactile Stimulation and tDCS Help Ine�cient BCI Users?

Brain-computer interface (BCI) has helped people by enabling them to control a computer or machine through brain activity without actual body movement. Despite this advantage, BCI cannot be used widely because some people cannot achieve controllable performance. To solve this problem, researchers have proposed stimulation methods to modulate relevant brain activity to improve BCI performance. However, multiple studies have reported mixed results following stimulation, and comparative study of different stimulation modalities has been overlooked. Accordingly, this comparative study was designed to investigate vibrotactile stimulation and transcranial direct current stimulation’s (tDCS) effects on brain activity modulation and motor imagery BCI performance among ine�cient BCI users. We recruited 44 subjects and divided them into sham, vibrotactile stimulation, and tDCS groups, and low performers were selected from each stimulation group. We found that the BCI performance of low performers in the vibrotactile stimulation group increased signi�cantly by 9.13% (p=0.0053), and while the tDCS group subjects’ performance increased by 5.13%, it was not signi�cant. In contrast, sham group subjects showed no increased performance. In addition to BCI performance, pre-stimulus alpha band power and the phase locking value (PLVs) averaged over sensory motor areas showed signi�cant increases in low performers following stimulation in the vibrotactile stimulation and tDCS groups, while sham stimulation group subjects and high performers across all groups showed no signi�cant stimulation effects. Our �ndings suggest that stimulation effects may differ depending upon BCI e�ciency, and ine�cient BCI users have greater plasticity than e�cient BCI users.
Apr 26, 2019 Absolute Quantification of Protein and mRNA Abundances Demonstrate Variability in GeneSpecific Translation

analytical 50 cm x 75 m memitter-column (New Objective). The peptides were eluted at 200 nL min (cid:1) 1 with an 8%–40% B240 min gradient (buffer B: 80% acetonitrile + 0.1% formic acid, buffer A: 0.1% formic acid) to a Q Exactive (Thermo Fisher Scientiﬁc) tandem mass spec-trometer operating with a top-10 strategy and a cycle time of 0.9 seconds. Brieﬂy, one 350-1 400 m/z MS scan at a resolution of R = 70,000 was followed by higher-energy collisional dissociation fragmentation (normalized collision energy of 25) of the were snap-frozen in liquid nitrogen, and metabolites were extracted using 1 mL of hot ethanol (70 (cid:4) C) in three consecutive rounds that were pooled together. The extracts were concentrated under vacuum. The metabolome samples analysed as using and Milford, according conﬁrmed for the spike-in standard. Pep-tide-spectrum match and protein false discovery rate (FDR) was kept below 1% using a target-decoy approach. The heavy spike-in standard was quantiﬁed using the iBAQ method as described by Scwanhausser et al (Schwanh € ausser et al., 2011). Essentially, protein intensities were divided by the number of theoretically observable peptides, log-transformed and plotted against log-trans-formed UPS2 mix (48 human proteins) known protein. This regression was then used to derive all other protein absolute quantities using their iBAQ intensities. Other parameters were set at their default values. To account for any mixing errors normalized H/L ratios (by shifting median peptide log H/L ratio to zero) were used for all down-stream quantitative analyses (Cox and Mann, 2008).
Comment on: Modelling the cost effectiveness of TNF antagonists in the management of rheumatoid arthritis: results from the British Society for Rheumatology Biologics Registry

Objective. To evaluate the cost effectiveness of TNF-� antagonist therapies for rheumatoid arthritis (RA) in the United Kingdom using data from the British Society for Rheumatology Biologics Registry (BSRBR). Methods. A simulation model is constructed to quantify the cost effectiveness of the TNF-� antagonist therapies (infliximab, etanercept and adalimumab) as a group versus traditional disease-modifying anti-rheumatic drugs, with a time horizon over the full patient lifetime. Participants are UK NHS patients in the BSRBR with RA who have failed at least two traditional disease-modifying anti-rheumatic drugs. The BSRBR aims to recruit all RA patients starting on a TNF-� antagonist agent and follows them 6 monthly via consultant and patient administered questionnaires. Data collected include disease activity scores (DAS28), the Health Assessment Questionnaire and the SF-36. Costs include drug, monitoring and hospitalisations. Benefits are measured in disability and quality of life improvements. The main outcome measure is the incremental cost per quality adjusted life-year gained (discounted). Results. The basecase cost per quality adjusted life-year gained by using TNF-� antagonist therapies is estimated at £23 882, with probabilistic uncertainty analysis suggesting that the probability that treatments are below £30 000 per QALY is around 84%. The results are most sensitive to assumptions concerning long-term disability progression, discount rates and the validity or otherwise of SF6D derived utility measures. Subgroup analysis, monotherapy versus combination with methotrexate, and a limited analysis of sequential therapy with two TNF-� antagonist agents, suggest cost-effectiveness ratios around £20 000 to £30 000. Conclusions. The BSRBR data provide valuable evidence for estimating cost-effectiveness. The analysis concludes that current policies and practice for the use of TNF-� antagonist therapies, after RA patients have failed at least two traditional disease-modifying anti-rheumatic drugs, appear cost-effective in the context of the NICE re-appraisal of 2006 for England and Wales, thus supporting their decision to continue their reimbursement. Decision-makers worldwide might adapt this analysis because differential costs, discount rates and other factors could affect results. There remains uncertainty, particularly on long-term disease progression. Further data collection using the BSRBR is recommended, together with a revision to this analysis when data become available.
un-Corneal Hydrops – Aetiology and Advanced Therapeutic Strategies Der korneale Hydrops – Ursachen und moderne Therapieansätze

Acute hydrops refers to sudden corneal edema caused by rupture of Descemet ʼ s membrane (DM) – often in progressive keratectasia. It leads to a sudden decrease in visual acuity, pain, and foreign body sensation as well as an increased glare sensation. Acute hydrops usually heals with scarring within months, but complications such as corneal perforation, infectious keratitis, and corneal vascularization may occur. The prevalence in keratoconus patients is 2.6 to 2.8%. Risk factors include keratoconjunctivitis vernalis, atopic dermatitis, high keratometry, male gender, and eye rubbing. Keratoplasty should be avoided in the acute phase. The prognosis of the graft is reduced, and after scar healing of the hydrops, wear-ing contact lenses or glasses may be possible again.
Shortened peginterferon and ribavirin treatment for chronic hepatitis c

Abubakar, I; Zignol, M; Falzon, D; Raviglione, M; Ditiu, L; Masham, S; Adetifa, I; Ford, N; Cox, H; Lawn, SD; +21 more. Marais, BJ; McHugh, TD; Mwaba, P; Bates, M; Lipman, M; Zijenah, L; Logan, S; McNerney, R; Zumla, A; Sarda, K; Nahid, P; Hoelscher, M; Pletschette, M; Memish, ZA; Kim, P; Hafner, R; Cole, S; Migliori, GB; Maeurer, M; Schito, M; Zumla, A; (2013) Drug-resistant tuberculosis: time for visionary political leadership. The Lancet infectious diseases. ISSN 1473-3099 DOI: https://doi.org/10.1016/S1473-3099(13)70030-6 Downloaded from: http://researchonline.lshtm. ac.uk/878910/
DISRUPTIONS IN THE REGULATION OF EXTRACELLULAR GLUTAMATE IN THE RAT CENTRAL NERVOUS SYSTEM AFTER DIFFUSE BRAIN INJURY

OF DISSERTATION DISRUPTIONS IN THE REGULATION OF EXTRACELLULAR GLUTATMATE AFTER DIFFUSE BRAIN INJURY By Jason Michael Hinzman Glutamate, the predominant excitatory neurotransmitter in the central nervous system, is involved in almost all aspects of neurological function including cognition, motor function, memory, learning, decision making, and neuronal plasticity. For normal neurological function, glutamate signaling must be properly regulated. Disrupted glutamate regulation plays a pivotal role in the acute pathophysiology of traumatic brain injury (TBI), disrupting neuronal signaling, initiating secondary injury cascades, and producing excitotoxicity. Increases in extracellular glutamate have been correlated with unfavorable outcomes in TBI survivors, emphasizing the importance of glutamate regulation. The aim of this thesis was to examine disruptions in the regulation of extracellular glutamate after experimental TBI. In these studies, we used glutamate-sensitive microelectrode arrays (MEAs) to examine the regulation of extracellular glutamate two days after diffuse brain injury. First, we examined which brain regions were vulnerable to post-traumatic increases in extracellular glutamate. We detected significant increases in extracellular glutamate in the dentate gyrus and striatum, which correlated to the severity of brain injury. Second, we examined the regulation of extracellular glutamate by neurons and glia to determine the mechanisms responsible for post-traumatic increases in extracellular glutamate. In the striatum of brain-injured rats, we detected significant disruptions in release of glutamate by neurons and significant decreases in the removal of glutamate from the extracellular space by glia. Third, we examined if a novel therapeutic strategy, a viral-vector mediated gene delivery approach, could improve the regulation of extracellular glutamate. Infusion of an adeno-associated virus expressing a glutamate transporter into the rat striatum produced significant improvements in glutamate clearance, identifying a novel strategy to reduce excitotoxicity. Lastly, we examined the translational potential of MEAs as novel neuromonitoring device for clinical TBI research. Overall, these studies have demonstrated the translational potential of MEAs to aid in the diagnosis and treatment of TBI survivors.
Competitive Stimulus Interactions within Single Response Fields of Superior Colliculus Neurons

In addition to its role in saccade generation, the superior colliculus (SC) is involved in target selection, saccade selection, and shifting the focus of spatial attention. Here, we investigated the influence of saccade selection on sensory interactions within single response fields (RFs) of SC neurons. One or two differently shaped stimuli were presented within single RFs of SC neurons, and the shape of a centrally located cue indicated whether and where to make a saccade (Go-Go) or whether to make or withhold a saccade (Go/No-Go). We found that, when two stimuli appeared at different locations within a single RF, SC neuronal activity was reduced compared with when a single stimulus appeared in isolation within the center of the RF in both the Go-Go and Go/No-Go tasks. In both tasks, a subsequent cue indicating one stimulus as a saccade target reduced the influence of the second stimulus located within the RF. We found that the time course of the suppression resulting from the two stimuli was ϳ130 ms, a time close to that seen in cortex. Finally, we found that the influence of two stimuli within single RFs of SC neurons changed over time in both the Go-Go and the Go/No-Go tasks. Initially, the neurons averaged the influence of two stimuli. As the trial progressed, the SC neurons signaled only the saccade vector that was produced. We conclude that cues to shift gaze, like attention, modulate the influence of sensory interactions, providing additional support for the linkage between attention and saccade selection.
Three‐Dimensional Reconstruction Optical System Using Shadows Triangulation

In this work is developed a three‐dimensional reconstruction system using the Shades3D tool of the Matlab® Programming Language and materials of low cost, such as webcam camera, a stick, a weak structured lighting system composed by a desk lamp, and observation plane in which the object is located. The reconstruction is obtained through a triangulation process that is executed after acquiring a sequence of images of the scene with a shadow projected on the object; additionally an image filtering process is done for obtaining only the part of the scene that will be reconstructed. Previously, it is necessary to develop a calibration process for determining the internal camera geometric and optical characteristics (intrinsic parameters), and the 3D position and orientation of the camera frame relative to a certain world coordinate system (extrinsic parameters). The lamp and the stick are used to produce a shadow which scans the object; in this technique, it is not necessary to know the position of the light .
Validation of the Intensity-Based Source Inversions of Three Destructive California Earthquakes

The objective of our work is to invert the intensities of preinstrumental destructive earthquakes to retrieve their principal source characteristics. This is relevant in countries (as Italy and Greece) where a large and high-quality data bank of earthquake intensities during the past few centuries exists. We have previously validated our technique presented in this journal for the M L 5.9 1987 Whittier Narrows earthquake, and here we demonstrate that our algorithm works on three other earthquakes with known sources. Three more validations of the algorithm are presented here by using the site intensities observed by the U.S. Geological Survey for the M 6.4 1983 Coalinga, the M S 7.1 1989 Loma Prieta, and the M w 6.7 1994 Northridge earthquakes. Our simplified KF formula simulates the body-wave radiation from a linear source, and 11 source parameters are retrieved: the three nucleation coordinates, the fault-plane solution, the seismic moment, the rupture velocities, the along- strike and antistrike rupture lengths, and the shear-wave velocity in the half-space. To find the minima on the hypersurface of the residuals in the multiparameter model space, we use a genetic process with niching (Niching Genetic Algorithm) because we have already shown that the problem is bimodal for pure dip-slip mechanisms. The objective function of the nonlinear inversion is the sum of the squared residuals (calculated-minus-observed intensity at all sites). The three tests presented here were successful because the results agreed with the sources already known from instrumental measurements. A very accurate solution was found for Loma Prieta, notwithstanding the complexity of its source. In the two other cases, sources close to the reference ones were retrieved. The quality of our source determinations are obviously lower than those of instrumentally based models, but would be highly noteworthy for earthquakes without seismological recordings. The potential of the “ KF inversions” seems particularly promising for European countries where seismicity rates are not very high, and where a lot of information on earthquake damage is available for preinstrumental earthquakes. The present series of validations raises our hope that further information on historic seismic events can be obtained from intensities, thus increasing the knowledge of seismotectonics and seismic hazard.
Differential Expression of the Estrogen Receptors α and β in the Rat Corpus Luteum of Pregnancy: Regulation by Prolactin and Placental Lactogens.

Estradiol, together with PRL and placental lactogens, regulates steroidogenesis and cell hypertrophy in the rat corpus luteum of pregnancy. Although binding experiments have demonstrated the presence of estrogen-binding sites, no evidence exists as to whether the rat corpus luteum of pregnancy expresses the estrogen receptor (ER) genes. In this investigation, we have analyzed the expression of the two ER genes (ERα and ERβ) (by RT-PCR and in situ hybridization) in the rat corpus luteum, studied their developmental changes throughout pregnancy, and investigated the regulation of ERα and ERβ messenger RNA (mRNA) expression by PRL and placental lactogens. The RT-PCR studies showed that both ER mRNA species (ERα and ERβ) are coexpressed in the rat corpus luteum during pregnancy. Whereas ERα mRNA increased from early pregnancy, reached a maximum at midpregnancy, and had a remarkable decline before parturition; ERβ mRNA remained constant throughout pregnancy, with a significant decline at parturition. Examinati.
Redesign of a Required Undergraduate Pharmacy Management Course to Improve Student Engagement and Concept Retention

Objective. To change the structure of a required pharmacy management course to make it more interactive and engaging for students. Design. The course is a required component of undergraduate curriculum and is completed over 2 semesters during the students’ third year. Changes included requiring students to lead classroom discussions and complete a business plan in groups. Assessment. A questionnaire centering on methods of delivery, course content, and outcomes was distributed in 2 academic years, with 74.7% of students responding. Even though the redesigned course required more time, there was strong support for the course among students because they realized the content contributed to their learning. Conclusion. A major course redesign is a big commitment by faculty members, but if done through consultations with former and current students, it can be rewarding for all involved. Students overwhelmingly embraced the changes to the course as they realized the restructuring and the resulting increase in workload were necessary to raise the relevance of the course to their future professional practice.
Quantification of regional myocardial blood flow using dynamic H2(15)O PET and factor analysis.

UNLABELLED Because the use of factor analysis has been proposed for extracting pure physiologic temporal or spatial information from dynamic nuclear medicine images, factor analysis should be capable of robustly estimating regional myocardial blood flow (rMBF) using H2(15)O PET without additional C15O PET, which is a cumbersome procedure for patients. Therefore, we measured rMBF using time-activity curves (TACs) obtained from factor analysis of dynamic myocardial H2(15)O PET images without the aid of C15O PET. METHODS H2(15)O PET of six healthy dogs at rest and during stress was performed simultaneously with microsphere studies using 85Sr, 46Sc, and 113SN: We performed factor analysis in two steps after reorienting and masking the images to include only the cardiac region. The first step discriminated each factor in the spatial distribution and acquired the input functions, and the second step extracted regional-tissue TACS: Image-derived input functions obtained by factor analysis were compared with those obtained by the sampling method. rMBF calculated using a compartmental model with tissue TACs from the second step of the factor analysis was compared with rMBF measured by microsphere studies. RESULTS Factor analysis was successful for all the dynamic H2(15)O PET images. The input functions obtained by factor analysis were nearly equal to those obtained by arterial blood sampling, except for the expected delay. The correlation between rMBF obtained by factor analysis and rMBF obtained by microsphere studies was good (r = 0.95). The correlation between rMBF obtained by the region-of-interest method and rMBF obtained by microsphere studies was also good (r = 0.93). CONCLUSION rMBF can be measured robustly by factor analysis using dynamic myocardial H2(15)O PET images without additional C15O blood-pool PET.