Miracle-dz/UniFAR-FTUs huggingface dataset:
Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro Imaging genetics through meta analysis ( ENIGMA ) Consortium

Citation for published version: Van Erp, TGM, Walton, E, Hibar, DP, Schmaal, L, Jiang, W, Glahn, DC, Pearlson, GD, Yao, N, Fukunaga, M, Hashimoto, R, Okada, N, Yamamori, H, Bustillo, JR, Clark, VP, Agartz, I, Mueller, BA, Cahn, W, De Zwarte, SMC, Hulshoff Pol, HE, Kahn, RS, Ophoff, RA, Van Haren, NEM, Andreassen, OA, Dale, AM, Doan, NT, Gurholt, TP, Hartberg, CB, Haukvik, UK, Jørgensen, KN, Lagerberg, TV, Melle, I, Westlye, LT, Gruber, O, Kraemer, B, Richter, A, Zilles, D, Calhoun, VD, Crespo-facorro, B, Roiz-santiañez, R, Tordesillas-gutiérrez, D, Loughland, C, Carr, VJ, Catts, S, Cropley, VL, Fullerton, JM, Green, MJ, Henskens, FA, Jablensky, A, Lenroot, RK, Mowry, BJ, Michie, PT, Pantelis, C, Quidé, Y, Schall, U, Scott, RJ, Cairns, MJ, Seal, M, Tooney, PA, Rasser, PE, Cooper, G, Shannon Weickert, C, Weickert, TW, Morris, DW, Hong, E, Kochunov, P, Beard, LM, Gur, RE, Gur, RC, Satterthwaite, TD, Wolf, DH, Belger, A, Brown, GG, Ford, JM, Macciardi, F, Mathalon, DH, O’leary, DS, Potkin, SG, Preda, A, Voyvodic, J, Lim, KO, Mcewen, S, Yang, F, Tan, Y, Tan, S, Wang, Z, Fan, F, Chen, J, Xiang, H, Tang, S, Guo, H, Wan, P, Wei, D, Bockholt, HJ, Ehrlich, S, Wolthusen, RPF, King, MD, Shoemaker, JM, Sponheim, SR, De Haan, L, Koenders, L, Machielsen, MW, Van Amelsvoort, T, Veltman, DJ, Assogna, F, Banaj, N, De Rossi, P, Iorio, M, Piras, F, Spalletta, G, Mckenna, PJ, Pomarol-clotet, E, Salvador, R, Corvin, A, Donohoe, G, Kelly, S, Whelan, CD, Dickie, EW, Rotenberg, D, Voineskos, AN, Ciufolini, S, Radua, J, Dazzan, P, Murray, R, Reis Marques, T, Simmons, A, Borgwardt, S, Egloff, L, Harrisberger, F, Riecher-rössler, A, Smieskova, R, Alpert, KI, Wang, L, Jönsson, EG, Koops, S, Sommer, IEC, Bertolino, A, Bonvino, A, Di Giorgio, A, Neilson, E, Mayer, AR, Stephen, JM, Kwon, JS, Yun, J, Cannon, DM, Mcdonald, C, Lebedeva, I, Tomyshev, AS, Akhadov, T, Kaleda, V, Fatouros-bergman, H, Flyckt, L, Busatto, GF, Rosa, PGP, Serpa, MH, Zanetti, MV, Hoschl, C, Skoch, A, Spaniel, F, Tomecek, D, Hagenaars, SP, Mcintosh, AM, Whalley, HC, Lawrie, SM, Knöchel, C, Oertel-knöchel, V, Stäblein, M, Howells, FM, Stein, DJ, Temmingh, HS, Uhlmann, A, Lopez-jaramillo, C, Dima, D, Mcmahon, A, Faskowitz, JI, Gutman, BA, Jahanshad, N, Thompson, PM, Turner, JA, Farde, L, Flyckt, L, Engberg, G, Erhardt, S, Fatouros-bergman, H, Cervenka, S, Schwieler, L, Piehl, F, Agartz, I, Collste, K, Victorsson, P, Malmqvist, A, Hedberg, M & Orhan, F 2018, 'Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro Imaging genetics through meta analysis (ENIGMA) Consortium', Biological Psychiatry, vol. 84, no. 1, e33, pp. 644-654. https://doi.org/10.1016/j.biopsych. 2018.04. 023
Adhesion of cells to polystyrene surfaces

The surface treatment of polystyrene, which is required to make polystyrene suitable for cell adhesion and spreading, was investigated. Examination of surfaces treated with sulfuric acid or various oxidizing agents using (a) x-ray photoelectron and attenuated total reflection spectroscopy and (b) measurement of surface carboxyl-, hydroxyl-, and sulfur-containing groups by various radiochemical methods showed that sulfuric acid produces an insignificant number of sulfonic acid groups on polystyrene. This technique together with various oxidation techniques that render surfaces suitable for cell culture generated high surface densities of hydroxyl groups. The importance of surface hydroxyl groups for the adhesion of baby hamster kidney cells or leukocytes was demonstrated by the inhibition of adhesion when these groups were blocked: blocking of carboxyl groups did not inhibit adhesion and may raise the adhesion of a surface. These results applied to cell adhesion in the presence and absence of serum. The relative unimportance of fibronectin for the adhesion and spreading of baby hamster kidney cells to hydroxyl-rich surfaces was concluded when cells spread on such surfaces after protein synthesis was inhibited with cycloheximide, fibronectin was removed by trypsinization, and trypsin activity was stopped with leupeptin.
Use of a watershed hydrologic model to estimate interbasin groundwater flow in a Costa Rican rainforest

The watershed hydrologic model TOPMODEL was used to estimate interbasin groundwater flow (IGF) into a small lowland rainforest watershed in Costa Rica. IGF is a common hydrological process but often difficult to quantify. Four‐year simulations (2006–2009) using three different model approaches gave estimates of IGF that were very similar to each other (10.1, 10.2, and 9.8 m/year) and to an earlier estimate (10.0 m/year) based on 1998–2002 data from a budget study that did not use a hydrologic simulation model, providing confidence in the new estimates and suggesting each of the three model approaches is viable. Results show no significant temporal variation in IGF during 2006–2009 (or between this period and the earlier study from 1998–2002). Simulations of the 16 consecutive 3‐month periods in 2006–2009 gave 16 values of IGF rate with a mean (10.1 m/year, standard deviation = 0.6 m/year) very similar to the estimates above from the 4‐year simulations. This suggests the modified version of TOPMODEL can be used to model stream discharge and estimate IGF for sub‐annual time periods during which change in water storage is not necessarily equal to zero. Thus, simple watershed models may be used to estimate IGF based on even relatively short calibration periods, making such models useful tools in the study of this widespread hydrological process that affects water and chemical fluxes and budgets but is often difficult and costly to quantify. Copyright © 2013 John Wiley & Sons, Ltd.
Quantitative Performance Evaluation of Navigation Solutions for Mobile Robots

All papers will be included in a workshop proceedings CD (12 pages per paper w/ 20 MB size limit). Preferred format is PDF. Please use the template and author instructions from http://www.roboticsconference. org/authors.shtml/. A website specific to this workshop has been setup at http://kaspar.informatik. uni-freiburg.de/~rss/. Program updates and news related to the workshop will be through this website. All papers, presentations, and a summary of the workshop will also be posted here after the workshop.
Interactive Charipinae Worldwide Database: a valuable tool for entomologists, agronomists and pest controllers

Els Charipinae (Hym.: Cynipoidea: Figitidae) son una subfamilia d'himenopters molt important, els seus membres son hiperparasits d'afids i psilids, i per tant estan involucrats en programes de control biologic de plagues. Despres d'haver dut a terme una revisio mundial dels Charipinae hem preparat una pagina web completa, on s'inclou tota la informacio sobre aquesta subfamilia. Aquest lloc web conte tota la informacio que ja es coneix sobre els Charipinae: clau generica, claus especifiques, una descripcio completa de cada especie valida, bibliografia i una aplicacio per comprovar els noms especifics i coneixer els valids. Al voltant de 1000 figures (optics i SEM) s'inclouen per il·lustrar els caracters diagnostics. L'objectiu principal es proporcionar a la comunitat cientifica de claus interactives per a la determinacio d'especies per part d'agronoms, ecolegs, filogenetics, biolegs, etc., (molts d'ells no familiaritzats amb la taxonomia de les vespes parasitaries) perque puguin utilitzar-los per avancar als seus estudis aixi com obtenir determinacions, figures i referencies. Aquest lloc web sera una important eina taxonomica que ajudara a portar a terme la investigacio ecologica, biologica i filogenetica.
Shaping neighbourhoods : a guide for health, sustainability and vitality

1. Orientation and Principles. Neighbourhood as Habitat. Neighbourhood in Focus. 2. Neighbourhood Checklists. Community Checklist. Investors Checklist. 3. A Neighbourhood Planning Process. Overview. The Collaborative Approach. Getting Going. Creating a Strategy. Making it Happen . Case Studies: 4. Providing for Local Needs. People and Community. Access to Jobs. Access to Local Facilities. Planning Movement. Case Studies. 5. Use of Local Resources. Energy. Water. Food, Waste. Biodiversity. Case Studies. 6. Neighbourhood Design. Neighbourhood Character. Key Structuring Elements. Shaping Towns and Townships. Designing Places. Case Studies. Sources. Index.
NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF- (cid:1) 1 -induced fibroblast differentiation into myofibroblasts

Background. Persistence of myofibroblasts is believed to contribute to the development of fibrosis in idiopathic pulmonary fibrosis (IPF). Transforming growth factor-ß1 (TGF-ß1) irreversibly converts fibroblasts into pathological myofibroblasts, which express smooth muscle (cid:1) -actin ( (cid:1) -SMA) and produce extracellular matrix proteins, such as procollagen I ( (cid:1) 1). Reactive oxygen species (ROS) produced by NADPH oxidases (NOX) have been shown to regulate cell differentiation. We hypothesized that NOX could be expressed in parenchymal pulmonary fibroblasts and could mediate TGF-ß1–stimulated conversion of fibroblasts to myofibroblasts. Methods. Fibroblasts were cultured from the lung of 9 Control and 8 IPF patients. We quantified NOX4, (cid:1) -SMA and procollagen I ( (cid:1) 1) mRNA and protein expression, ROS production and Smad2/3 phosphorylation, in the absence and in the presence of incubation with TGF-ß1. PDGF-induced fibroblasts migration was also assessed. Results. We found that (1) NOX4 mRNA and protein expression was upregulated in pulmonary fibroblasts from patients with IPF and correlated with mRNA expression of (cid:1) SMA and procollagen I ( (cid:1) 1) mRNA; (2) TGF-ß1 upregulated NOX4, (cid:1) -SMA and procollagen I ( (cid:1) 1) expression in control and IPF fibroblasts; (3) the change in (cid:1) -SMA and procollagen I ( (cid:1) 1) expression in response to TGF-ß1 was inhibited by antioxidants and by a NOX4 siRNA; (4) NOX4 modulated (cid:1) -SMA and procollagen I ( (cid:1)
International Journal of Systematic and Evolutionary Microbiology (2004), 54, 551–556 DOI 10.1099/ijs.0.02912-0 Correspondence

Fourteen homofermentative lactic acid bacteria that were isolated from kefir grains and kefir fermented milks were assigned to either Lactobacillus kefiranofaciens or Lactobacillus kefirgranum, based on their characteristic morphotypes, phenotypic features and SDS-PAGE profiles of whole-cell proteins. Further genotypic analyses on representative strains from both taxa demonstrated that L. kefiranofaciens and L. kefirgranum share 100 % 16S rDNA sequence similarity and belong phylogenetically to the Lactobacillus acidophilus species group. DNA–DNA binding values of >79 % and analogous DNA G+C contents of 37–38 mol% showed that the strains studied belonged to one species: L. kefirgranum is a later synonym of L. kefiranofaciens. An emended description is proposed for L. kefiranofaciens. Due to the specific morphological and biochemical characteristics of these taxa in kefir grain formation, it is proposed that Kefir is a traditional dairy product that originated from the Caucasus. It is obtained by fermentation of milk at room temperature, using kefir grains as starters. Kefir grains are a naturally immobilized starter; they are made of a complex association of microorganisms that are more or less embedded in a biopolymer called kefiran. During the last 40 years, many studies have focused on analysis of kefir grain microflora. It contains Gram-positive homoferment-ative and heterofermentative lactic acid bacteria (lactoba-cilli, lactococci and leuconostocs), Gram-negative acetic acid bacteria (Acetobacter) and both lactose-fermenting (Kluyveromyces marxianus and Kluyveromyces lactis) and non-fermenting (mostly Saccharomyces species) yeasts L. kefirgranum are both homofermentative lactobacilli that seem to be major microbial constituents of kefir grains. L. kefiranofaciens strains form very viscous colonies and are responsible for the formation of kefiran, one of the major polysaccharides that forms kefir grains (Mukai et al., 1990; Yokoi et al., 1991). In the process of a biodiversity study of several kefir grains and kefir fermented milks, a large number of bacterial strains were isolated on MLR medium (milk-based agar) after anaerobic incubation at 30 uC. MLR medium was prepared by mixing 1 vol. 3 % agar solution in water (autoclaved for 15 min at 120 uC and cooled to 60 uC) with 1 vol. UHT (ultra high temperature-treated) milk that contained 10 g filter-sterilized yeast extract l 21 and 10 g filter-sterilized glucose l 21 and was acidified to pH 5? 4 with acetic acid. All strains were cultivated and maintained on MLR medium unless indicated otherwise. Bacteriological purity was checked by plating and examining living and Gram-stained cells. Fourteen isolates were selected for further research. …
Correlating laboratory observations of fracture mechanical properties to hydraulically-induced microseismicity in geothermal reservoirs.

To date, microseismicity has provided an invaluable tool for delineating the fracture network produced by hydraulic stimulation of geothermal reservoirs. While the locations of microseismic events are of fundamental importance, there is a wealth of information that can be gleaned from the induced seismicity (e.g. fault plane solutions, seismic moment tensors, source characteristics). Closer scrutiny of the spatial and temporal evolution of seismic moment tensors can shed light on systematic characteristics of fractures in the geothermal reservoir. When related to observations from laboratory experiments, these systematic trends can be interpreted in terms of mechanical processes that most likely operate in the fracture network. This paper reports on mechanical properties that can be inferred from observations of microseismicity in geothermal systems. These properties lead to interpretations about fracture initiation, seismicity induced after hydraulic shut-in, spatial evolution of linked fractures, and temporal evolution of fracture strength. The correlations highlight the fact that a combination of temperature, stressing rate, time, and fluid-rock interactions can alter the mechanical and fluid transport properties of fractures in geothermal systems.
The Prosthechea prismatocarpa complex (Orchidaceae: Laeliinae) in Costa Rica, with a new species, P. tardiflora

Se presenta una revision del complejo de Prosthechea prismatocarpa (Orchidaceae: Laeliinae) en Costa Rica, con una clave de las especies y su taxonomia actualizada. Se describe una nueva especie, P. tardiflora Mora-Retana ex Pupulin. Dentro del complejo, la nueva especie se puede reconocer por el rizoma corto, la inflorescencia producida en el pseudobulbo del ano anterior, las flores inodoras, los sepalos agudos y doblados en la base, el istmo del labelo ancho y el lobulo medio corto.
Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

We aimed to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on the order of micrometers, with a focus on the quantitative identification of calcium oxalate monohydrate (COM) and dihydrate (COD). Fourier Transform Infrared (FTIR) spectroscopy, powder X-ray diffraction (PXRD), and microfocus X-ray CT measurements (micro-CT) were performed, and the results were compared. The extended analysis method of the FTIR spectrum, focusing on the 780 cm−1 peak, made it possible to achieve a reliable analysis of the COM/COD ratio. We succeeded in the quantitative analysis of COM/COD in the region of 50 × 50 μm by microscopic FTIR for thin sections of kidney stones, and by the micro-CT for bulk samples. The extended analysis method of the FTIR spectrum focusing on the 780 cm−1 peak was introduced to analyze the COM/COD ratio. The analysis results based on PXRD measurement with micro sampling, microscopic FTIR analysis of a thin section, and micro-CT observation of a bulk sample of a kidney stone showed roughly consistent results, indicating that all methods can be used complementarily. This quantitative analysis method evaluates the detailed CaOx composition on the preserved stone surface and provides information on the stone formation processes and interactions with organic molecules.
Evidence of prezygotic isolation, but not assortative mating, between locally adapted populations of Fundulus heteroclitus across a salinity gradient

Selection along environmental gradients can drive reproductive isolation and speciation. Among fishes, salinity is a major factor limiting species distributions and, despite its importance in generating species diversity, transitions between marine and freshwater are rare. Here, we tested for mechanisms of reproductive isolation between locally adapted freshwater and brackish water-native populations of killifish, Fundulus heteroclitus, from either side of a hybrid zone along a salinity gradient. There was evidence for pre-zygotic endogenous reproductive isolation with reduced fertilization success between crosses of freshwater-native males and brackish water-native females. Exogenous pre-zygotic isolation was also present where females had highest fertilization in their native salinity. We used a replicated mass spawning design to test for mate choice in both brackish and fresh water. After genotyping 187 parents and 2,523 offspring at 2,347 SNPs across the genome, 85% of offspring were successfully assign to their parents. However, no reinforcing mate choice was observed. These results therefore demonstrate emerging, yet limited, reproductive isolation and incipient speciation across a marine to freshwater salinity gradient and suggest that both endogenous and exogenous mechanisms, but not assortative mating, contribute to divergence.
Downscaling of categorical soil maps with the aid of auxiliary spatial soil information and data mining methods

Kategoria tipusu talajterkepek terbeli felbontasanak javitasara (leskalazasara) adatbanyaszati modszerkent osztalyozo fakat alkalmaztunk. A feladat elvegzeset az indokolta, hogy bizonyos tematikus talajterkepek nem allnak rendelkezesre a megkivant leptekben. A szamos előnnyel biro dontesi fak felhasznalhatok tobbek kozott letező talajterkepekben foglalt talaj-taj modellek megertesere, a felvetelezesi, szerkesztesi szabalyok utolagos formalizalasara. A feltart, dontesi szabalyokba foglalt osszefuggesek pedig nagy felbontasu kornyezeti segedvaltozok segitsegevel terbelileg finomitott terkepek előallitasat teszik lehetőve. Ezen segedvaltozok kozott specialis szerepet toltenek be a nagyobb terbeli felbontasu, de elterő tematikaju talajtani informaciok. A szintetizalo munka eredmenyekent szuletett Agrotopografiai terkepek agrookologiai egysegei dontően a Kreybig-fele talajfelvetelezes adataira alapozva, a Kreybig terkepek talajfoltjainak terbeli es tematikus generalizalasaval jottek letre. A Kreybig mintazat j.
The 11-beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

Citation for published version: Rosenstock, J, Banarer, S, Fonseca, VA, Inzucchi, SE, Sun, W, Yao, W, Hollis, G, Flores, R, Levy, R, Williams, WV, Seckl, JR, Huber, R & INCB13739-202 Principal Investigat 2010, 'The 11-betaHydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy' Diabetes Care, vol. 33, no. 7, pp. 15161522. DOI: 10.2337/dc09-2315
A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domain

Indirect immunofluorescence was used to establish a domain-specific marker for hepatocyte plasma membranes. In frozen sections of fixed rat liver (0.5-4 microns), antibodies directed against rat intestinal leucine aminopeptidase (LAP) recognized an antigen that was restricted to the bile canalicular plasma membrane. Fluorescence was not observed on the sinusoidal or lateral membranes, and intracellular staining was not detected. The liver antigen was identified as LAP, based on its chemical similarity to intestinal LAP. First, immunoprecipitation experiments using trypsin-solubilized intestinal LAP (G-200 fraction, 91% pure) established a correlation between the loss of LAP enzyme activity from the soluble fraction and the appearance in the specific immunoprecipitates of polypeptides migrating on SDS PAGE between 110,000 and 130,000 daltons. The antigen precipitated from a detergent extract of liver plasma membranes had the same electrophoretic mobility. Second, the chymotryptic map of the major band in the liver immunoprecipitate was similar to that of purified intestinal LAP.
Spreading process of the northern Mariana Trough: Rifting‐spreading transition at 22°N

We have conducted a geophysical survey of the northern Mariana Trough from 19°N to 24°N. The trough evolves southward from incipient rifting to seafloor spreading within this region. This study aims to clarify the location and time of the rifting‐to‐spreading transition, which was controversial previously, and processes of seafloor spreading after the transition. The new data set includes swath bathymetry with side‐scan images and magnetic vector anomaly. The mantle Bouguer gravity anomaly (MBA) was calculated using the free‐air gravity anomaly from satellite altimetry. The rifting‐to‐spreading transition occurs at about 22°N, which is proved by seafloor‐spreading fabric in the bathymetry, clear magnetic lineations, and the bull's‐eye pattern in MBA. Four ridge segments separated by three nontransform discontinuities are recognized between 19°N and 22°N. The northernmost segment has relatively abundant magma supply compared with the other segments, which is estimated from a larger segment length, shallower axial depths with no rift valley, and lower MBA. The next segment to the south is, on the other hand, a magma‐starved segment with a prominent rift valley. Two anomalously deep grabens (called the Central Grabens) formed by amagmatic extension occur near the segment ends. The succession of magma‐rich, magma‐starved, and normal segments with increasing distance from the volcanic arc is the same as the observation in the Lau Basin reported by Martinez and Taylor [2002]. The magnetic anomaly revealed the detailed history of the spreading. The seafloor spreading between 19°N and 20°N began prior to 5 Ma, and that between 20°N and 21°30′N began at about 4 Ma. Spreading half‐rates in the western side of the spreading center were 2 to 3 cm/year before 2.58 Ma south of 21°30′N and during the Matuyama Chron north of 21°30′N, but an average during the Brunhes Chron is 1 cm/year or less. Orientations of the ridge axes, which range from −20° to 0° at present, have rotated about 20° clockwise since the start of the spreading. These changes in rate and direction might be associated with changes in the motion of the Philippine Sea plate. Spreading has been asymmetric in the northern Mariana Trough. The spreading rates of the western side of the spreading center have been significantly larger than the eastern counterpart in general. The asymmetry may have been caused by an interaction of mantle upwelling systems under the volcanic front and the backarc spreading center and would be a characteristic of backarc spreading.