Miracle-dz/UniFAR-FTUs huggingface dataset:
Sound Transmission Through a Double-Wall Structure Coupled with Two Trapezoidal Acoustic Cavities

This paper aims at investigating the sound transmission mechanism of a flexibly-linked finite length double-wall structure. The problem stems from the modeling of sound transmission through corrugated core sandwich panels for predicting its transmission loss. The spatial segmentation of the acoustic gap and fully structure-acoustic coupling effect between the flexural vibration of the inclined mechanical link and the two adjacent trapezoidal acoustic cavities are considered. The theoretical model of the considered vibro-acoustic system is developed by using the modal superposition method in conjunction with envelope rectangular technique. Based on the developed theoretical model, the general vibro-acoustics characteristics of the system is presented. Particularly by using the (0, 0) mode of the acoustic cavity and the first structural modal frequency, the ratio between the aerostatic stiffness and the structural stiffness is formulated, and a criterion is proposed to determine whether the sound insulation performance of the vibro-acoustic system is controlled mainly by the structure or the acoustic cavity. Numerical investigations reveal that with different stiffness ratio, the acoustic cavity affects the sound transmission through both the added stiffness and added mass following different mechanisms. Besides, the influence of the inclined angle of the connecting beam on sound insulation performance of the double-wall structure is also studied. The obtained results are believed to be helpful in the optimal design of corrugated core sandwich panels for sound insulation.
New insights into the multiferroic properties of Mn3TeO6

Mn3TeO6 has a trigonal corundum related structure (space group R3¯), and orders in an incommensurate antiferromagnetic (AFM) structure at TN ≈ 24 K. A weak ferroelectric order below T * ~ 21 K has recently been reported. In order to investigate possible structural changes below TN leading to the observed dipole order, we have performed a detailed study of the crystal and magnetic structures of Mn3TeO6 using neutron powder diffraction (NPD) in the temperature range of 5–40 K. Complementary low-temperature second harmonic generation (SHG) measurements were performed in order to confirm the reported dipole order at T *. No change in the rhombohedral symmetry associated with a possible displacive phase transition at T * was observed in the long-range structural correlations, and it appears that Mn3TeO6 keeps the same incommensurately modulated magnetic spin structure with the propagation vector k = (0; 0; 0.43) in the whole temperature range from 5 to 24 K.
Clinicoradiological Risk Factors Associated with Inability to Achieve Minimum Clinically Important Difference in Operated Cases of Cervical Spondylotic Myelopathy

Study Design This is a retrospective cohort study. Purpose This study aimed to identify the clinicoradiological risk factors associated with the inability to achieve minimum clinically important difference (MCID) on the modified Japanese Orthopaedic Association (mJOA) Scale in operated cases of cervical spondylotic myelopathy (CSM). Overview of Literature Only a few studies have evaluated the outcomes of surgery performed for CSM using MCID on the mJOA scale. Methods We analyzed 124 operated CSM cases from March 2019 to April 2021 for preoperative clinical features, cervical sagittal radiographic parameters, and magnetic resonance imaging (MRI) signal intensities (SI). The risk factors associated with missing the MCID (poor outcome) on mJOA at the final follow-up were identified using binary logistic regression. Multivariate analysis was used to find significant risk factors, and odds ratios (OR) were computed. Results A total of 110 men (89.2%) and 14 women (10.8%) with an average age of 53.5±13.2 years were included in the analysis. During the last follow-up, 89 cases (72.1%) achieved MCID (meaningful gains following surgery) while 35 (27.9%) could not. The final model identified the following parameters as significant risk factors for poor outcome: increased duration of symptoms (OR, 6.77; p=0.001), lower preoperative mJOA scale (OR, 0.75; p=0.029), the presence of multilevel T2-weighted (T2W) MRI SI (OR, 4.79; p=0.004), and larger change in cervical sagittal vertical axis (ΔcSVA) (OR, 1.06; p=0.013). Also, an increase in cSVA postoperatively correlated with a reduced functional recovery rate (r=−0.4, p<0.001). Conclusions Surgery for CSM leads to significant functional benefits. However, poorer outcomes are observed in cases of greater duration of symptoms, higher preoperative severity with multilevel T2W MRI SI, and a larger increase in the postoperative cSVA (sagittal imbalance).
Expressions of Gratitude and Positive Emotion among Hemodialysis Patients: Qualitative Findings.

Objectives The current qualitative inquiry solicited hemodialysis (HD) patients to identify events or incidences that have gone well in their day-to-day life, things they consider to be blessings, and to further reflect on the contributors of such events. Methods Hemodialysis patients kept an electronic journal using investigator-purchased tablet computers. Results Multiple themes emerged for which HD patients expressed gratitude: 1) life itself, 2) positive or improving health 3) family interactions and social support, 4) clinic resources, favorable treatment therapy, and staff, and 5) other small events. Conclusions Clinicians are urged to explore the psychological assets that HD patients possess with a focus on how these might be further cultivated and whether their amplification leads to improved quality of life.
Parsing variance by marker type: Testing biogeographic hypotheses and differential contribution of historical processes to population structure in a desert lizard

A fundamental goal of population genetic studies is to identify historical biogeographic patterns and understand the processes that generate them. However, localized demographic events can skew population genetic inference. Assessing populations with multiple types of genetic markers, each with unique mutation rates and responses to changes in population size, can help to identify potentially confounding population‐specific demographic processes. Here, we compared population structure and connectivity inferred from microsatellites and restriction site‐associated DNA loci among 17 populations of an arid‐specialist lizard, the desert night lizard, Xantusia vigilis, in central California to test among historical processes structuring population genetic diversity. We found that both marker types yielded generally concordant insights into population genetic structure including a major phylogenetic break maintained between two populations separated by less than 10 km, suggesting that either marker type could be used to understand generalized demographic patterns across the region for management purposes. However, we also found that the effects of demography on marker discordance could be used to elucidate population histories and distinguish among competing biogeographic hypotheses. Our results suggest that comparisons of within‐population diversity across marker types provide powerful opportunities for leveraging marker discordance, particularly for understanding the creation and maintenance of contact zones among clades.
NAC1 confines virus‐specific memory formation of CD4+ T cells through the ROCK1‐mediated pathway

Nucleus accumbens‐associated protein 1 (NAC1), a transcriptional cofactor, has been found to play important roles in regulating regulatory T cells, CD8+ T cells, and antitumor immunity, but little is known about its effects on T‐cell memory. In this study, we found that NAC1 expression restricts memory formation of CD4+ T cells during viral infection. Analysis of CD4+ T cells from wild‐type (WT) and NAC1‐deficient (−/−) mice showed that NAC1 is essential for T‐cell metabolism, including glycolysis and oxidative phosphorylation, and supports CD4+ T‐cell survival in vitro. We further demonstrated that a deficiency of NAC1 downregulates glycolysis and correlates with the AMPK‐mTOR pathway and causes autophagy defective in CD4+ T cells. Loss of NAC1 reduced the expression of ROCK1 and the phosphorylation and stabilization of BECLIN1. However, a forced expression of ROCK1 in NAC1−/− CD4+ T cells restored autophagy and the activity of the AMPK‐mTOR pathway. In animal experiments, adoptively transferred NAC1−/− CD4+ T cells or NAC1−/− mice challenged with VACV showed enhanced formation of VACV‐specific CD4+ memory T cells compared to adoptively transferred WT CD4+ T cells or WT mice. This memory T‐cell formation enhancement was abrogated by forcing expression of ROCK1. Our study reveals a novel role for NAC1 as a suppressor of CD4+ T‐cell memory formation and suggests that targeting NAC1 could be a new approach to promoting memory CD4+ T‐cell development, which is critical for an effective immune response against pathogens.
Laboratory demonstration of the piezoelectric figure correction of a cylindrical slumped glass optic

The X-ray Surveyor is a mission concept for a next generation X-ray observatory. This mission will feature roughly 30 times the effective area of the Chandra Observatory while matching its sub-arcsecond angular resolution. The key to meeting these requirements is lightweight, segmented optics. To ensure these optics achieve and maintain sub-arcsecond performance, we propose to use piezoelectric coatings for post-bonding and on-orbit figure correction. We have fabricated a cylindrical prototype optic with piezoelectric adjusters and measured its performance using optical metrology. We present the results of this experiment and discuss their implications for an observatory featuring adjustable X-ray optics.
e-Delphi Study: Expert Consensus on the Needs and Resources Available to Family Caregivers of Individuals with Substance Use Disorder

Abstract Background Family caregivers of individuals with substance use disorder (SUD) experience a significant burden and have few evidence-based resources available. Aim To obtain a consensus of expert views on the needs, and resources available, to family caregivers of individuals with SUD given the COVID-19 pandemic and other sociopolitical factors. Methods Quantitative design using the Classic e-Delphi method of multiple iterations of questioning to reach a consensus among expert panelists. Purposive sampling was used to recruit a multidisciplinary, nationwide panel of SUD experts from professional contacts, professional organization list servers, websites relevant to support groups for family caregivers, flyers, and word of mouth. In round 1 panelists (n = 96) responded to open-ended questions about the support provided to family caregivers, and the additional needs of family caregivers. In subsequent rounds, the panel rated collated responses in terms of agreement (n = 54) and importance (n = 48). Results Thematic content analysis identified ten needs in the resources available to family caregivers. Consensus was obtained across thematic categories and the remaining items were ranked according to importance. Conclusions Participatory-based SUD research that includes the expertise of healthcare providers, support leaders, and family caregivers is necessary to develop evidence-based interventions to increase caregiver resilience and facilitate coping. Several clear conclusions that address social and structural determinants of health emerged, including the need for increased access to healthcare and community services, more self-care strategies for families, and focused public advocacy to reduce SUD-related stigma.
Prescription patterns of P2Y12 inhibitors following revascularization in the United States: 2013–2018

P2Y12 inhibitors (i.e., clopidogrel, prasugrel, or ticagrelor) are effective at reducing adverse cardiovascular outcomes post‐revascularization in coronary artery disease (CAD). However, the choice of a specific P2Y12 inhibitor may vary according to the patient's characteristics, and trends in the use of different P2Y12 inhibitors are not well studied in real‐world settings. The objective of this study is to determine trends in the prescription patterns of P2Y12 inhibitors in patients with CAD. We studied 137,073 patients with CAD cross‐sectionally using the IBM MarketScan database (2013–2018). Patients with CAD prescribed P2Y12 inhibitors within 14 days of index revascularization were included to compare the utilization of P2Y12 inhibitors based on age and clinical characteristics. There were differences in prescription patterns by age. Among patients aged less than or equal to 65 years (N = 92,734), a continuously increased utilization of ticagrelor was observed from 13.7% to 45.6% replacing clopidogrel as the most prescribed medication by 2018. Similarly, ticagrelor was the choice of drug among patients undergoing percutaneous coronary intervention. Among the patients at high bleeding risk, clopidogrel remained the most prescribed medication with use in 50.6% of patients in 2018 in patients aged less than or equal to 65 years. Contrarily, among the older adults with age 65 or above (N = 44,339), although ticagrelor use increased with time, clopidogrel remained the most utilized drug and was used by 66.2% of patients in 2018. Additionally, clopidogrel was the preferred medication among patients with stroke history. With the increasing use of ticagrelor in real‐world practice, further research is needed to observe its impact on cardiovascular outcomes.
Clinical improvement after Essure® devices removal: a systematic review

Abstract Purpose Essure® implant is a permanently implanted minimally invasive birth control device for women (female sterilisation) widely used between 2002 and 2018. Many adverse events were reported by patients. Increasingly removal procedures have been performed in symptomatic patients. However, there is a lack of in-depth studies on clinical improvement after Essure® removal. We aimed to review all clinical studies about symptoms and quality of life (QoL) after removal procedures. Materials and methods A review of literature in electronic search in Medline and Embase databases from January 2002 to January 2022 using the following keywords: Essure; Essure removal; quality of life; symptomatology improvement. Results Out of 764 articles in the initial database, 18 clinical studies were eligible for inclusion in our literature review. Overall clinical improvement rates after removal ranged from 21% to 98%. All symptoms were less frequent after Essure® removal, although with large discrepancies between studies. Lack of improvement was reported between 1% to 15% of patients. Rate of patients with improvement of QoL after removal ranged from 58 to 98%. The pain was reported as significantly reduced after the surgery. Conclusions In the available literature, Essure® removal in symptomatic patients may improve symptoms and quality of life. This should be discussed in the benefits and risks ratio before deciding on the best option of management. Short condensation Essure® removal in symptomatic patients may improve symptoms and quality of life.
Transport at Strong Coupling and Black Hole Dynamics

In this thesis we study aspects of transport in strongly coupled quantum systems with broken translational symmetry. Using holographic duality, we also examine the associated dynamical problem in asymptotically Anti-de Sitter, spatially modulated black holes. More precisely, in chapter 2 we consider the transport of conserved charges in spatially inhomogeneous quantum systems with a discrete lattice symmetry. When the DC conductivities are finite, we derive a set of generalised Einstein relations, relating the diffusion constants of the conserved charges to the DC conductivities and static susceptibilities. We also develop a long-wavelength expansion in order to explicitly construct the heat and charge diffusive modes within hydrodynamics on curved manifolds. In chapter 3 we used analogous techniques to construct the thermoelectric diffusive quasinormal modes in a large class of black hole spacetimes that are holographically dual to strongly coupled field theories in which spatial translations are broken explicitly. These modes satisfy a set of constraints on the black hole horizon, from which we find that their dispersion relations are given by the generalised Einstein relations. In chapter 4 we define a boost incoherent current in spontaneously modulated phases, and we show that in holographic theories, its DC conductivity can be obtained from solving a system of horizon Stokes equations.
A SCUBA-2 850 MICRON SURVEY OF CIRCUMSTELLAR DISKS IN THE λ ORIONIS CLUSTER

We present results from an 850 μm survey of the ∼5 Myr old λ Orionis star-forming region. We used the SCUBA-2 camera on the James Clerk Maxwell Telescope to survey a ∼0. °5-diameter circular region containing 36 (out of 59) cluster members with infrared excesses indicative of circumstellar disks. We detected only one object at > 3 &sgr; ? > significance, the Herbig Ae star HD 245185, with a flux density of ∼74 mJy beam−1 corresponding to a dust mass of ∼150 M ⨁ ? > . Stacking the individually undetected sources did not produce a significant mean signal but gives an upper limit on the average dust mass for λ Orionis disks of ∼3 M ⨁ ? > . Our follow-up observations of HD 245185 with the Submillimeter Array found weak CO 2–1 line emission with an integrated flux of ∼170 mJy km s−1 but no 13CO or C18O isotopologue emission at 30 mJy km s−1 sensitivity, suggesting a gas mass of ≲ 1 ? > M Jup ? > . The implied gas-to-dust ratio is thus ≳ 50 ? > times lower than the canonical interstellar medium value, setting HD 245185 apart from other Herbig Ae disks of similar age, which have been found to be gas rich; as HD 245185 also shows signs of accretion, we may be catching it in the final phases of disk clearing. Our study of the λ Orionis cluster places quantitative constraints on planet formation timescales, indicating that at ∼5 Myr the average disk no longer has sufficient dust and gas to form giant planets and perhaps even super-Earths; the bulk material has been mostly dispersed or is locked in pebbles/planetesimals larger than a few mm in size.
Efficient Similarity Search on Distribution Data

Distribution data naturally arise in countless domains, such as meteorology, biology, geology, industry and economics. However, relatively little attention has been paid to data mining for large distribution sets. Given n distributions of multiple categories and a query distribution Q, we want to find similar clouds (i.e., distributions), to discover patterns, rules and outlier clouds. We propose to address this problem and present D-Search, an efficient algorithm for similarity search in large distribution datasets. Our main contributions are (1) approximate KL divergence, which can speed up cloud-similarity computations by using SVD coefficients, (2) multi-step sequential scan, which efficiently prunes a significant number of search candidates and leads to a direct reduction in the search cost. We also introduce an extended version of D-Search : (3) time-series distribution mining, which uses the D-Search algorithm and finds similar subsequences in time-series distribution datasets. Extensive experiments on real multi-dimensional datasets show that our method achieves up to 2,300 faster wall-clock time over the naive implementation while it does not sacrifice accuracy.
Regulation of Star Formation Amidst Heating and Cooling in Galaxies and Galaxy Clusters

Galaxy clusters are the largest gravitationally bound systems in the Universe and often host the largest galaxies (known as the brightest cluster galaxies (BCG)) at its centers. These BCG’s are embedded in hot 1-10 keV X-ray gas. A subset of galaxy clusters known as cool-core clusters show sharply peaked X-ray emission and high central densities, demonstrating cooling of the surrounding halo gas in timescales much shorter than a Hubble time. These observations led to the development of a simple cooling flow model. In the absence of an external heating process, a cooling flow model predicts that the hot intracluster medium gas in these dense cores would hydrostatically cool, generating cooling flows in the center of the cluster. This cooled gas will eventually collapse to form stars and contribute to the bulk of galaxy mass. The rates of star formation actually observed in the clusters however are far less than predicted by the cooling flow model, suggesting a non-gravitational heating source. Active galactic nuclei (AGN), galaxies hosting a supermassive black hole that ejects outflows via accretion, is currently the leading heating mechanism (referred to as AGN feedback) explaining the observed deficit in the star formation rates. AGN feedback also offers an elegant explanation to the observed black hole and galaxy coevolution. Much of the evidence for AGN feedback has been obtained from studies focussed on galaxy clusters and luminous massive systems with little evidence that it occurs in more typical systems in the local universe. Our research investigates this less explored area to address the importance of AGN heating in the regulation of star formation in typical early type galaxies in the local universe. We selected a sample of 200+ early type, low redshift galaxies and carried out a multiple wavelength study using archival observed in the UV, IR and radio. Our results suggest that early type galaxies in the
1‐Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro

Lung cancer is the leading cause of cancer‐related death worldwide and non‐small cell lung cancer (NSCLC) represents 85%. Mougeotia nummuloides and Spirulina major have been reported to possess anticancer properties. 1‐Monopalmitin (1‐Mono) is the principle active constituent in these natural plants. It is debating whether 1‐Mono exerts antitumor effects. Therefore, we explored the role of 1‐Mono in lung cancer in vitro. Results showed that 1‐Mono significantly inhibited A549 and SPC‐A1 cell proliferation, induced G2/M arrest and caspase‐dependent apoptosis. Moreover, it suppressed the protein expression of inhibitors of apoptosis proteins (IAPs). It was further demonstrated that 1‐Mono activated the PI3K/Akt pathway, suppression of PI3K/Akt activities with LY294002 and Wortmannin partially attenuated 1‐Mono‐mediated anticancer activities, indicating that 1‐Mono‐induced antitumor effects is dependent on PI3K/Akt pathway. 1‐Mono induced cytoprotective autophagy since autophagy inhibitor Chloroquine dramatically enhanced 1‐Mono‐induced cytotoxicity. In summary, our results showed 1‐Mono kills lung cancer through PI3K/Akt pathway, providing novel options for lung cancer administration.
Simulation of swirl-stabilized turbulent partially premixed combustion

ABSTRACT Properly describing turbulence-complex reaction interactions is crucial for predicting turbulent combustion and pollutant emission. A presumed probability density function model for temperature fluctuation is adopted in the present paper. It incorporates a 25-step skeletal mechanism for methane combustion. The gas turbulent transport is simulated with the algebraic Reynolds stress model for turbulence-swirl interactions. These models are applied to the simulation of swirl-stabilized turbulent partially premixed jet flame. The calculated gas velocities, fluctuating velocities, Reynolds shear stresses, temperature, and species mass fractions are in agreement with the measured test data.