Miracle-dz/UniFAR-FTUs huggingface dataset:
Small Changes in the Regulation of One Arabidopsis Profilin Isovariant, PRF1, Alter Seedling Development

Profilin (PRF) is a low-molecular-weight actin binding protein encoded by a diverse gene family in plants. Arabidopsis PRF1 transcripts are moderately well expressed in all vegetative organs. A regulatory mutant in PRF1, prf1-1, was isolated from a library of T-DNA insertions. The insertion disrupted the promoter region of PRF1 100 bp upstream from the transcriptional start site. Although steady state levels of PRF1 transcripts appeared normal in mature prf1-1 plants, the levels in young seedlings were only one-half those observed in wild type. Reactions with a PRF1 isovariant–specific monoclonal antiserum and general anti-profilin antisera demonstrated that PRF1 protein levels also were one-half those found in wild-type seedlings, although total profilin levels were unaffected. Mutant seedlings no longer could downregulate PRF1 levels in the light, as did wild type. Consistent with their molecular phenotypes, young mutant seedlings displayed several morphological phenotypes but developed into apparently normal adult plants. Their initial germination rate and development were slow, and they produced excessive numbers of root hairs. Mutant seedlings had abnormally raised cotyledons, elongated hypocotyls, and elongated cells in the hypocotyl, typical of phenotypes associated with some defects in light and circadian responses. A wild-type PRF1 transgene fully complements the hypocotyl phenotypes in the prf1-1 mutant. The ability of profilin to regulate actin polymerization and participate directly in signal transduction pathways is discussed in light of the prf1-1 phenotypes.
Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials

The first-in-class Bruton’s tyrosine kinase inhibitor ibrutinib has proven clinical benefit in B-cell malignancies; however, atrial fibrillation (AF) has been reported in 6–16% of ibrutinib patients. We pooled data from 1505 chronic lymphocytic leukemia and mantle cell lymphoma patients enrolled in four large, randomized, controlled studies to characterize AF with ibrutinib and its management. AF incidence was 6.5% [95% Confidence Interval (CI): 4.8, 8.5] for ibrutinib at 16.6-months versus 1.6% (95%CI: 0.8, 2.8) for comparator and 10.4% (95%CI: 8.4, 12.9) at the 36-month follow up; estimated cumulative incidence: 13.8% (95%CI: 11.2, 16.8). Ibrutinib treatment, prior history of AF and age 65 years or over were independent risk factors for AF. Multiple AF events were more common with ibrutinib (44.9%; comparator, 16.7%) among patients with AF. Most (85.7%) patients with AF did not discontinue ibrutinib, and more than half received common anticoagulant/antiplatelet medications on study. Low-grade bleeds were more frequent with ibrutinib, but serious bleeds were uncommon (ibrutinib, 2.9%; comparator, 2.0%). Although the AF rate among older non-trial patients with comorbidities is likely underestimated by this dataset, these results suggest that AF among clinical trial patients is generally manageable without ibrutinib discontinuation (clinicaltrials.gov identifier: 01578707, 01722487, 01611090, 01646021).
Detection of laryngeal carcinoma and epithelial hyperplastic laryngeal lesions via a rapid-access dysphonia clinic

Recent government initiatives in the UK have focused on streamlining oncology services by reducing waiting times between urgent referral, assessment and treatment of patients with possible cancer. The performance of the Quick Early Diagnosis Dysphonia Clinic of the Queen Elizabeth Hospital, Birmingham, between May 1997 and April 2001 was reviewed. Of 721 patients reviewed, 123 (17 per cent) had clinically suspicious laryngeal lesions. Thirteen cases of epithelial hyperplastic laryngeal lesions and 27 laryngeal malignancies were diagnosed. There was no statistical link between early cancer detection and assessment within two weeks of referral. However, rapid-access clinics for dysphonia serve an important role in the reassurance and multidisciplinary management of patients with persistent hoarseness. Greater financial commitments are necessary to achieve compliance with objectives for a maximum two-week wait for patients with suspected laryngeal malignancy.
Emission Trading Scheme and the Price of Energy

This research analyzes the relationship between the carbon and the energy market. These two markets are linked together on a regulatory and on a structural basis. The energy sector is the most important industry within the European Emission Trading Scheme (EU ETS): as main producers of carbon emissions they are also the main users of carbon allowances. The question we address here is if there is a direct link between the carbon spot market and the energy spot market. We investigate the correlation, called pass through rate (PTR) between the energy and carbon market. Our findings show that the PTR is extremely volatile, and it depends on time frame and purposes of the energy market players. This leads to an intervention by policy makers and regulators to define the rules framework of the EU ETS.
ADDRESSING DIVERSITY IN MINDFULNESS RESEARCH ON HEALTH: A NARRATIVE REVIEW USING THE ADDRESSING FRAMEWORK.

This Reviews is brought to you for free and open access by the Rowan University Journals at Rowan Digital Works. It has been accepted for inclusion in Cooper Rowan Medical Journal by an authorized editor of Rowan Digital Works. For more information, please contact brush@rowan.edu. Recommended Citation Chin, Gabrielle; Anyanso, Vanessa; and Greeson, Jeffrey (2019) "Addressing Diversity in Mindfulness Research on Health: A Narrative Review using the ADDRESSING Framework," Cooper Rowan Medical Journal: Vol. 1: Iss. 1, Article 2. DOI: issn.2578-3343_vol1iss1. 2 Available at: https://rdw.rowan.edu/crjcsm/vol1/iss1/2 Cooper Rowan Medical Journal: https://rdw.rowan.edu/crjcsm
Modeling and analysis of higher-order interactions in collaborative networks

Interactions between the individuals involved in a complex collaborative network cannot always be accurately described by pairwise relations alone. We survey the literature on such systems, where higher-order (beyond pair-wise) relations between the components are necessary to capture the nature of the entire system. We are particularly interested in the applications of the simplicial complex model, in which the fact that a group of individuals as a whole (e.g. { Alice, Bob, Carol } ) is in the relation, implies that all smaller subsets of this group are in the same relation. However, we do not limit ourselves to only this model, and also consider hypergraphs, bipartite graphs, and graph module decompositions, if they work better in a particular case. We review a broad range of networks that possess high-order interactions: scientiﬁc co-authorship, social networks, biological examples such as protein-protein interactions and species co-occurrence. Since we are speciﬁcally interested in the simplicial complex model, we also give a brief review on computing their topological properties such as Betti numbers, and describe some standard geometric complexes (Cech and Vietoris-Rips). Then we consider the applications to games, and the concepts of joint information and correlation. After that, we talk about computational aspects on using simplicial complexes, specialized data structures and algorithms, such as the simplex tree data structure.
Receptor binding and internalization of a water-soluble (1-->3)-beta-D-glucan biologic response modifier in two monocyte/macrophage cell lines.

Glucan phosphate, a water-soluble, chemically defined (1-->3)-beta-D-glucan biologic response modifier, has been reported to exert antisepsis activity and accelerate wound healing. In this study we describe the specific binding of glucan phosphate to human and murine monocyte/macrophage cell lines, U937 and J774A.1, respectively. At 37 degrees C, equilibrium binding was rapidly achieved, i.e., within 1 min. In U937 cells, binding occurred with an affinity (Kd) of 37 microM and a Bmax of 65 x 106 binding sites/cell at 37 degrees C. In J774A.1 cells, glucan phosphate bound with an affinity (Kd) of 24 microM and a Bmax of 53 x 106 binding sites/cell at 37 degrees C. In both cases there was insignificant nonspecific binding. We further demonstrated that bound glucan phosphate cannot be displaced by a 50-fold excess of unlabeled ligand, suggesting internalization of glucan phosphate. Transmission electron microscopy showed significantly increased cytoplasmic vacuolization and significantly decreased mitotic activity in glucan phosphate-treated U937 cells compared with that in untreated cells. Pullulan, a random coil alpha-(1-->4)-(1-->6)-linked glucose polymer that served as a control, did not compete for the same binding site as glucan phosphate in either cell line, indicating the specificity of the binding site for (1-->3)-beta-D-glucans. We conclude that water-soluble pharmaceutical grade (1-->3)-beta-D-glucan phosphate specifically binds to and is internalized by U937 and J774A.1 cells.
The phenomenon of treatment failures in Human African Trypanosomiasis

Treatment of Human African Trypanosomiasis (HAT or sleeping sickness) relies on a few drugs which are old, toxic and expensive. The most important drug for the treatment of second stage infection is melarsoprol. During the last 50 years treatment failures with melarsoprol were not a major problem in Trypanosoma brucei gambiense patients. Commonly a relapse rate of 5–8% was reported, but in recent years it has increased dramatically in some important foci of T. b. gambiense sleeping sickness. Treatment failures for T. b. rhodesiense are much less of a problem apart from some reports between 1960 and 1985 of refractoriness in T. b. rhodesiense patients in East Africa. Analysis of those isolates revealed that their in vitro sensitivity to melarsoprol was one‐tenth that of sensitive isolates, and complete failure to cure the infection in the acute mouse model with melarsoprol levels comparable with those in human patients. There was very little indication of resistance in T. b. gambiense isolates from Côte d’Ivoire and NW Uganda. The in vitro melarsoprol sensitivities for populations from relapsing and from curable patients were in the same range. Melarsoprol concentrations in the plasma and cerebrospinal fluid of patients 24 h after treatment did not show any difference between patients who relapsed and those who could be cured. The reason for relapses in the recent T. b. gambiense epidemics are not known. Other parasite‐related factors might be involved, e.g. affinity to extravascular sites other than the CNS which are less accessible to the drug. In conclusion, a combination of factors rather than a single one may be responsible for the phenomenon of melarsoprol treatment failures in T. b. gambiense patients.
The effect of single-detector CT versus MDCT on clinical outcomes in patients with suspected acute pulmonary embolism and negative results on CT pulmonary angiography.

OBJECTIVE We sought to compare the clinical outcomes of patients in whom pulmonary embolism (PE) has been ruled out with single-detector CT versus MDCT, given the improved visualization of subsegmental clots with the latter and the recent increase in use of CT for evaluation of PE. SUBJECTS AND METHODS Two cohorts of patients undergoing CT for suspected PE with either single-detector CT (3-mm collimation and pitch of 1.7) or MDCT (2-mm collimation and pitch of 1) scanners were prospectively observed and compared using predefined criteria for evidence of subsequent thromboembolic disease during the 6 months after the acquisition of their initial scan. RESULTS Ninety-eight patients were scanned using a single-detector CT scanner. Of these, none had evidence of subsequent PE or deep venous thrombosis (DVT), and six (6.1%) died of unrelated causes. Of the 100 patients scanned using an MDCT scanner, one (1.0%) had a subsequent nonfatal PE 2 months after the initial scanning, one (1.0%) had DVT 1 month after the initial scanning, and eight (8.0%) died of unrelated causes. No significant difference was found in either the probability of subsequent thromboembolic events (chi(2) = 0.3183, degrees of freedom [df] = 1, p = 1) or frequency of unrelated deaths (chi(2) = 0.2655, df = 1, p = 0.7829) between patients scanned using single-detector CT or MDCT protocols. CONCLUSION Our results show that patients with suspected acute PE and negative CT results have acceptable clinical outcomes in the absence of anticoagulation treatment up to 6 months after acquisition of their initial scan. Furthermore, we found that the increased visualization of smaller, more peripheral arteries afforded by multislice technology did not affect clinical outcome.
Predicting folivorous primate abundance: Validation of a nutritional model

Understanding the determinants of animal abundance has become more vital as ecologists are increasingly asked to apply their knowledge to the construction of informed management plans. However, there are few general models are available to explain variation in abundance. Some notable exceptions are studies of folivorous primates, in which the protein‐to‐fiber ratio of foods has been shown to predict biomass. Here we examine the generality of Milton's [American Naturalist 114:363–378, 1979] protein/fiber model by providing a detailed analysis of diet selection in black‐and‐white colobus monkeys (Colobus guereza), and applying the model to populations shown to be stable; an assumption not previously examined. Based on observations of two groups of black‐and‐white colobus in Kibale National Park, Uganda, and one group in a forest fragment, we documented that the animals selected young leaves that had more protein, were more digestible, and had a higher protein‐to‐fiber ratio than mature leaves. The mature leaves did not differ from young leaves with respect to secondary compounds or mineral content (with the exceptions of copper and zinc). All of the colobus groups selected foods with a high protein‐to‐fiber ratios. However, one group also selected more digestible foods, and in another group, foraging efforts were positively related to zinc and negatively related to potassium. Previous studies that examined Milton's protein/fiber model did not demonstrate that the study populations were stable. If some populations were not at carrying capacity, then the correlations drawn between food availability and/or quality and folivore biomass may have been spurious. To address this issue, we censused a series of forest fragments in 1995 and again in 2000. We found that the populations in these fragments had declined from 165 in 1995 to 119 animals in 2000. However, based on evidence of population stability and lack of forest disturbance, we concluded that five of the original populations were stable. The biomass of these populations was related to the protein‐to‐fiber ratio of the fragment's trees. Combining our data with published data, we demonstrate that the protein‐to‐fiber ratios of mature leaves available to these folivorous primates accounted for 87% of the variance in their biomass. Am. J. Primatol. 62:55‐69, 2004. © 2004 Wiley‐Liss, Inc.
An auto-scoring billiards system

Recently, since the opening climate of Taiwanese society, the billiards becomes more and more popular. Besides, the sport association and interested persons also encouraged not only the activity but also setup the club among many colleges that further push billiards fast developing. Meanwhile, because many males and females billiards won the expecting good prizes at international races, the billiards has achieved unheard-of climate. In tradition, billiards has the artificial scoring which not only lack of automatic method to record the each ball which been hit into pocket when player win the game but also without the backend analysis system. Therefore, our system combined the RFID, TCP/IP and IR with Internet sense capability to make use of UML Object-based analysis technology. We implemented the client/server model using C++ programming language to design the 9.Ball@RFID system having the characteristics of instant record (Tag sensor), analysis (database), broadcast (Webcam) which should be used to train athletic for recording the analysis of batting steps but also for the billiards race to setup the live scoring. After the system testing, the reliability has an acceptable level at 96.47% for identification the billiards' balls. It shall be a good model of billiards table manufacturers for future commercialization because that the prototype developing cost is low.
Properties of perimetric threshold estimates from Full Threshold, SITA Standard, and SITA Fast strategies.

PURPOSE To investigate the distributions of threshold estimates with the Swedish Interactive Threshold Algorithms (SITA) Standard, SITA Fast, and the Full Threshold algorithm (Humphrey Field Analyzer; Zeiss-Humphrey Instruments, Dublin, CA) and to compare the pointwise test-retest variability of these strategies. METHODS One eye of 49 patients (mean age, 61.6 years; range, 22-81) with glaucoma (Mean Deviation mean, -7.13 dB; range, +1.8 to -23.9 dB) was examined four times with each of the three strategies. The mean and median SITA Standard and SITA Fast threshold estimates were compared with a "best available" estimate of sensitivity (mean results of three Full Threshold tests). Pointwise 90% retest limits (5th and 95th percentiles of retest thresholds) were derived to assess the reproducibility of individual threshold estimates. RESULTS The differences between the threshold estimates of the SITA and Full Threshold strategies were largest ( approximately 3 dB) for midrange sensitivities ( approximately 15 dB). The threshold distributions of SITA were considerably different from those of the Full Threshold strategy. The differences remained of similar magnitude when the analysis was repeated on a subset of 20 locations that are examined early during the course of a Full Threshold examination. With sensitivities above 25 dB, both SITA strategies exhibited lower test-retest variability than the Full Threshold strategy. Below 25 dB, the retest intervals of SITA Standard were slightly smaller than those of the Full Threshold strategy, whereas those of SITA Fast were larger. CONCLUSIONS SITA Standard may be superior to the Full Threshold strategy for monitoring patients with visual field loss. The greater test-retest variability of SITA Fast in areas of low sensitivity is likely to offset the benefit of even shorter test durations with this strategy. The sensitivity differences between the SITA and Full Threshold strategies may relate to factors other than reduced fatigue. They are, however, small in comparison to the test-retest variability.
The Role of Early Career Factors in Academic Patenting

This paper explores the characteristics of persistent academic inventors and how they are influenced by their personal attributes, PhD institution, and first invention. Using a novel dataset on 555 UK academic inventors, we find that the quality of the first invention is the best predictor for subsequent participation in the patenting process. We further find evidence for a positive training effect whereby researchers that were trained at universities that had already established commercialisation units have a higher propensity to patent persistently. In addition, researchers that gained first patenting experience in industry are able to benefit from stronger knowledge flows and receive more citations than their purely academic peers.
Effectiveness of Base in Prism for Presbyopes with Convergence Insufficiency

Purpose. Although the treatment of symptomatic convergence insufficiency (CI) with base-in (BI) prism in adults has a strong theoretical foundation, there have been very few studies addressing its efficacy. The purpose of this study was to investigate whether the application of BI prism, using a novel progressive addition lens design which incorporates BI prism in the near portion only, could help alleviate the symptoms in presbyopes with CI. Methods. A total of 29 symptomatic CI subjects aged 45 to 68 years were examined. All subjects took the CI Symptom Survey V-15 (CISS) and scored ≥16 points. Each subject was assigned two pairs of progressive addition glasses made by the same manufacturer in a randomized sequence, one with BI prism and one with the same lens prescription but no prism (placebo). Subjects wore each pair of glasses for 3 weeks and completed the CISS at the end of the 3rd week. Symptom level measured with CISS was the major outcome measure. Results. The mean (standard deviation) CISS score was 30.21 (9.30) at baseline and decreased to 13.38 (9.44) with the BI-prism glasses, vs. 23.62 (10.76) with the placebo glasses. There were significant differences between the baseline survey score and the score with the BI-prism glasses (p < 0.0001) and between the score with placebo glasses and the one with BI-prism glasses (p = 0.001). Conclusions. The progressive addition glasses with BI-prism were found to be effective in alleviating symptoms of presbyopes with symptomatic CI.
On the application of forwarding to generalized Hamiltonian systems

Generalized Hamiltonian systems (GHS) are a class of nonlinear systems of significant interest in control theory, due to the passivity property and the particular structure of the state equations. Control techniques that obtain, by state feedback, a closed-loop generalized Hamiltonian dynamics, are suitable for easy stabilization by passive output feedback, yielding dissipative systems. In Hamiltonian systems with dissipation, the conservative and dissipative parts are clearly identifiable, and the Lyapunov function is chosen as the closed-loop energy function or Hamiltonian. A deeper insight suggest that this convenient Hamiltonian form may also underlie other classical techniques. It has already been observed that some control methodologies preserve the Hamiltonian structure, as long as the open-loop dynamics is also Hamiltonian. This is the case of cascade controllers like backstepping. Whereas the relation between backstepping control and Hamiltonian structures has been recently reported, this works unveils the preservation of the Hamiltonian structure in a class of forwarding-controlled systems. The forwarding procedure is assumed to start from a Hamiltonian subsystem and after each step of the forwarding iteration, a new Hamiltonian structure is obtained, i.e., the GHS structure is preserved. Moreover, the conservative or dissipative nature of the original system is also preserved. The result can be extended to any number of iteration steps, and hence to arbitrary order systems.
Determinants of clinical outcome and survival in acromegaly

OBJECTIVE The extent to which treatment modifies the excess in morbidity and mortality in acromegaly remains uncertain. This study investigates the determinants of final outcome following therapy for acromegaly. DESIGN A retrospective analysis of patients treated at the Departments of Endocrinology and Neurosurgery, Auckland Hospital, New Zealand.