Miracle-dz/UniFAR-FTUs huggingface dataset:
Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of β-Catenin

The deubiquitinating enzyme USP14 has been identified and biochemically studied, but its role in lung cancer remains to be elucidated. The aim of this study was to evaluate the prognostic significance of USP14 in patients with lung adenocarcinoma and to define its role in lung cancer cell proliferation. USP14 mRNA levels in different non-small cell lung cancer (NSCLC) cell lines were detected by real-time qPCR. USP14 protein levels in surgically resected samples from NSCLC patients, and in NSCLC cell lines, were detected by immunohistochemistry or Western blot. The correlation of USP14 expression with clinical characteristics and prognosis was determined by survival analysis. After silencing USP14, cell proliferation was assessed by MTT assay and the cell cycle was measured by FACS assay. It was found that USP14 expression was upregulated in NSCLC cells, especially in adenocarcinoma cells. Over-expression of USP14 was associated with shorter overall survival of patients. Downregulation of USP14 expression arrested the cell cycle, which may be related to β-catenin degradation. Over-expression of USP14 was associated with poor prognosis in NSCLC patients and promoted tumor cell proliferation, which suggests that USP14 is a tumor-promoting factor and a promising therapeutic target for NSCLC.
Sustainable Faculty Development: An Indonesian Case Study

This paper describes a five-year Canadian-Indonesian faculty development project that involved a range of activities and resulted in sustainable faculty development: the creation of faculty development centres in two post-secondary institutions. The mentor-mentee literature that framed the experience resulted in a gradual shifting of responsibility from the Canadians to the Indonesians. Analysis of the experience resulted in five key points that might inform faculty development practice whether internationally or locally. The key points are: time to develop expertise, understanding the multiple cultural contexts, modelling a range of different kinds of knowledge, sharing an external object of study, and changing the nature of problem solving and posing.
Recycling as Altruistic Behavior

Experimental and survey data were gathered from residents of a large urban neighborhood with a community wide curbside recycling program in order to determine the extent to which recycling could be conceptualized as altruistic behavior. Results confirmed that recycling behavior is consistent with Schwartz's altruism model, according to which behavior is influenced by social norms, personal norms, and awareness of consequences. Data further showed that a block-leader program, in which residents encouraged their neighbors to recycle, influenced altruistic norms and increased recycling behavior. Prompting and information strategies were also introduced into the community recycling program as experimental interventions in order to com- pare their effects with the block-leader approach. Results showed that prompting and information increased recycling behavior but did not affect norms and attitudes. Further- more, all the intervention strategies influenced behavior independently of the measured norms; block leaders had the most substantial impact, prompts had the next greatest impact, and information had the least.
Self-Paced Path Control as an Optimization Task

An optimization model of human motor control in a laterally constrained self-paced path control task (e. g., driving) is proposed. The model structures the task as intermittent control with Begg's relationship used to describe the growth of lateral error with distance traveled during the sampling interval. Rewards and penalties are explicitly present in the objective function to be optimized. The path geometry is used with nonlinear optimization to solve the model and show that it has the expected reactions to payoff changes. Tests of the model against existing data in the literature and directly against the data from laboratory subjects showed a very close correspondence in form and numerical values between the model's prediction and human subject's performance.
Phytochemistryical & Anthelmintic Studies on Blumea Lacera

Purpose - The burden of ill health due to anthelmintic infection increasing day by day, in addition to this present anthelmintics are suffering from the problems of resistance and side effects, so it is strictly recommended to find out the anthelmintic drug with assured safety and less chances of resistance. Ayurweda is considered as one of the safest system of medicine and number of plant has reported for anthelmintic use, but activity of those plants is not proved scientifically in case of number of plants. Present study is based on the same objective so as to make an attempt to find out, to evaluate and to prove the anthelmintic activity of ayurvedic plant Blumea lacera scientifically. Methods - Extraction was made by soxhelation and maceration for extraction of alcoholic and aqueous extract respectively, freshly prepared extract was first used for preliminary phytochmical investigation then screened for in-vitro anthelmintic activity against Ascaris lumbricoides and Pheritema postuma by using piperazine citrate as standard. Results and Conclusions - The results of study found that the plant Blumea lacera possess good anthelmintic activity in dose dependent manner. © 2011 IGJPS. All rights reserved.
Book reviews : Health and Deprivation: Inequality and the North Peter Townsend, Peter Phillimore and Alistair Beattie Croom Helm, London, 1988 £19.95, £8.95 pbk

population and as a means of securing mass loyalty to the state’s authority. The limits to the state’s policy-making role is determined by the undermining of the basis of legitimation, and . the public sector unions seek to manipulate these limits as they engage in political forms of action in opposition to the state’s and management’s policies. Through the application of technical rationality, however (in which political issues or practical problems are transformed into technical problems and solutions), state management increases its scope to impose control stwctures on its
Design and characterization of a 12.8GB/s low power differential memory system for mobile applications

This paper describes the design and characterization of a low power differential memory interface targeted for mobile applications. The initial design of the memory interface achieves 2.7 to 4.3GB/s data bandwidth and consumes 3.3mW/Gb/s at 4.3GB/s operation. The design allows two x16 stacked dies to be fit into a 12mm PoP package, achieving a 12.8GB/s aggregated data bandwidth based on 3.2Gb/s per pin. A low swing signaling based on a voltage-mode differential driver is reviewed and its performance is analyzed. We demonstrate that, compared to LPDDR2 memory interface based on single-ended signaling, the differential memory interface overcomes most of channel related issues such as crosstalk and SSO noise and provides a very clean channel response. Thus, the resulting extra system margin can be used to compensate for extra timing jitter and system noise, enabling lower power and lower system cost. To evaluate the impact of timing jitter and system noise to system performance, a statistical link modeling and simulation methodology is employed. Two test systems are built based on wirebond-based Package-on-Package (PoP) and BGA-based Chip-to-Chip (C2C) module to characterize the memory system performance and to validate the memory statistical link model. The correlation result showed a good agreement in the system bit error rates (BER) between measurement and simulation.
The Devil Is in the Deliberation: Thinking Too Much Reduces Preference Consistency

In five experiments we found that deliberation reduces preference consistency. In experiments 1 and 2, participants who deliberated on their preferences were less consistent in their evaluations compared to those who did not deliberate. Experiment 3 demonstrated that this effect is due to the impediment of deliberation and not to the benefit of nondeliberation. We hypothesized that deliberation leads to the inconsistent weighting of information, especially when the information is complex. As such, we predicted and found in experiments 4 and 5 that the extent to which deliberation decreases preference consistency depends upon the complexity of the information.
CheB is required for behavioural responses to negative stimuli during chemotaxis in Bacillus subtilis

The methyl‐accepting chemotaxis protein, McpB, is the sole receptor mediating asparagine chemotaxis in Bacillus subtilis. In this study, we show that wild‐type B. subtilis cells contain ≈ 2000 copies of McpB per cell, that these receptors are localized polarly, and that titration of only a few receptors is sufficient to generate a detectable behavioural response. In contrast to the wild type, a cheB mutant was incapable of tumbling in response to decreasing concentrations of asparagine, but the cheB mutant was able to accumulate to low concentrations of asparagine in the capillary assay, as observed previously in response to azetidine‐2‐carboxylate. Furthermore, net demethylation of McpB is logarithmically dependent on asparagine concentration, with half‐maximal demethylation of McpB occurring when only 3% of the receptors are titrated. Because the corresponding methanol production is exponentially dependent on attractant concentration, net methylation changes and increased turnover of methyl groups must occur on McpB at high concentrations of asparagine. Together, the data support the hypothesis that methylation changes occur on asparagine‐bound McpB to enhance the dynamic range of the receptor complex and to enable the cell to respond to a negative stimulus, such as removal of asparagine.
Interlinking Multimedia - Principles and Requirements

The linked data principles have gained a huge momentum by providing means to interlink datasets and by that contributing to a rich user experience on the Web. Methods to interlink data however still do not cover multimedia content in a sufficient way, as Interlinking Multimedia requires more than just putting resources globally in relation to each other. In order to close this gap, we propose a set of principles and requirements for interlinking multimedia content on the Web. As one major source we have identified user interaction to establish static or dynamic links between (parts of) multimedia resources.
Microfluidic Platform for Cell Isolation and Manipulation Based on Cell Properties

In molecular and cellular biological research, cell isolation and sorting are required for accurate investigation of a specific cell types. By employing unique cell properties to distinguish between cell types, rapid and accurate sorting with high efficiency is possible. Though conventional methods can provide high efficiency sorting using the specific properties of cell, microfluidics systems pave the way to utilize multiple cell properties in a single pass. This improves the selectivity of target cells from multiple cell types with increased purity and recovery rate while maintaining higher throughput comparable to conventional systems. This review covers the breadth of microfluidic platforms for isolation of cellular subtypes based on their intrinsic (e.g., electrical, magnetic, and compressibility) and extrinsic properties (e.g., size, shape, morphology and surface markers). The review concludes by highlighting the advantages and limitations of the reviewed techniques which then suggests future research directions. Addressing these challenges will lead to improved purity, throughput, viability and recovery of cells and be an enabler for novel downstream analysis of cells.
Analysis of Working Memory and Its Capacity Limit in Visual and Auditory Information

This study is an analysis of working memory capacity in the context of both visual and auditory information. Working memory storage capacity is important because cognitive tasks can be completed only with sufficient ability to hold information as it is processed. The ability to repeat information depends on task demands but can be distinguished from a more constant, underlying mechanism: a central memory store limited to 3 to 5 meaningful items in young adults. The purpose of this study is to use strategies that can increase the efficiency of the use of a limited capacity or allow the maintenance of additional information separate from that limited capacity. The researcher will discuss why this central limit is important, how it can be observed, how it differs among individuals, and why it may exist. The review focuses on the term nature of capacity limits, storage capacity limit, views of researchers on working memory, and evidences of both visual and auditory working memory. The results suggest a focus on central capacity limits that are beneficial in predicting which thought processes individuals can do, and in understanding individual differences in cognitive maturity and intellectual aptitude.
Architecture for a distributed openflow controller

Considering the modern internet traffic rates, the network architecture is of particular importance as the running services itself. On the other hand, due to the increasing complexity and black-box structure of the available networking hardware (switches, routers, etc.), the necessary network innovation imposed by the running services becomes infeasible in practice. The software-defined networking notion introduced to solve this problem and one of its emerging and powerful implementations, the OpenFlow protocol, advocate the idea of providing the control and data paths in separate planes. A network operating system running on this control plane, is anticipated to provide necessary measures for scalability and reliability in order to stand against the gigantic traffic pumped by the network. In this paper, we propose a distributed OpenFlow network operating system built with necessary scalability and reliability qualifications without requiring any changes to the existing OpenFlow protocol and networking equipment.
GridStix: supporting flood prediction using embedded hardware and next generation grid middleware

The cost of damage caused by flooding is directly related to the warning-time given before a flood occurs. Therefore, improving the coverage, accuracy and reliability of flood prediction systems is of great importance. This paper proposes a novel Grid-based approach to supporting flood prediction through the use of embedded sensor nodes equipped with wireless networking technology. These nodes implement a light-weight Grid capable of collecting and transmitting data gathered by flood sensors for off-site analysis. Additionally, the nodes are capable of performing basic on-site analysis that is used to inform system behavior. The proposed system utilizes Lancaster's next-generation component-based Grid middleware platform 'GridKit', which offers inherent support for reconfiguration, embedded devices and heterogeneous network technologies, making it ideally suited to this application
The Phenomenon Happiness: Prolegomena to a Phenomenological Description

This article argues that phenomenology should investigate the phenomenon human happiness because this distinctive style of philosophizing has the potential to make a special contribution to the determination of the highest human good. This distinctive contribution is a function of the phenomenological method, which generally involves the performance of the phenomenological epoche and the execution of the transcendental reduction with respect to the acts of consciousness and their correlatively constituted objects. By means of an axiological application of the phenomenological method specifically to this fundamental ethical and practical question, it becomes possible to distinguish in a rigorous manner between what people think or feel happiness is and what it genuinely is. For example, the phenomenological approach to happiness enables people to neutralize their natural attitude toward the perceived highest good, in which it is given naively and straightforwardly, and to adopt the transcendental attitude .
Using Priors to Improve Estimates of Music Structure

Existing collections of annotations of musical structure possess many strong regularities: for example, the lengths of segments are approximately log-normally distributed, as is the number of segments per annotation; and the lengths of two adjacent segments are highly likely to have an integer ratio. Since many aspects of structural annotations are highly regular, but few of these regularities are taken into account by current algorithms, we propose several methods of improving predictions of musical structure by using their likelihood according to prior distributions. We test the use of priors to improve a committee of basic segmentation algorithms, and to improve a committee of cutting-edge approaches submitted to MIREX. In both cases, we are unable to improve on the best committee member, meaning that our proposed approach is outperformed by simple parameter tuning. The same negative result was found despite incorporating the priors in multiple ways. To explain the result, we show that although there is a correlation overall between output accuracy and prior likelihood, the weakness of the correlation in the high-likelihood region makes the proposed method infeasible. We suggest that to improve on the state of the art using prior likelihoods, these ought to be incorporated at a deeper level of the algorithm.
Children's Questions and the War

SECONDARY schools are engaged in a great variety of activities in their efforts to aid in the prosecution of the war. Shop facilities are being used to train industrial workers as well as members of the armed forces; many rural high schools are meeting six days a, week in order to dismiss earlier and enable boys to go to work on the farm; more high-school buildings are being kept open evenings to provide family recreation and escape from war tensions; children are being conditioned physically so that they will be better able to endure the strenuous life of a nation at war; teachers and pupils are gathering bundles for Britain, making Red Cross supplies, and practicing first aid; and some schools are placing more and more emphasis on democratic practices. The Educational Policies Commission has recently issued a pronouncement on war policy for American schools. The commissioners write:
Perception for a river mapping robot

Rivers with heavy vegetation are hard to map from the air. Here we consider the task of mapping their course and the vegetation along the shores with the specific intent of determining river width and canopy height. A complication in such riverine environments is that only intermittent GPS may be available depending on the thickness of the surrounding canopy. We present a multimodal perception system to be used for the active exploration and mapping of a river from a small rotorcraft flying a few meters above the water. We describe three key components that use computer vision, laser scanning, and inertial sensing to follow the river without the use of a prior map, estimate motion of the rotorcraft, ensure collision-free operation, and create a three dimensional representation of the riverine environment. While the ability to fly simplifies the navigation problem, it also introduces an additional set of constraints in terms of size, weight and power. Hence, our solutions are cognizant of the need to perform multi-kilometer missions with a small payload. We present experimental results along a 2km loop of river using a surrogate system.
KCNQ1 and KCNE1 in the IKs Channel Complex Make State-dependent Contacts in their Extracellular Domains

KCNQ1 and KCNE1 (Q1 and E1) associate to form the slow delayed rectifier IKs channels in the heart. A short stretch of eight amino acids at the extracellular end of S1 in Q1 (positions 140–147) harbors six arrhythmia-associated mutations. Some of these mutations affect the Q1 channel function only when coexpressed with E1, suggesting that this Q1 region may engage in the interaction with E1 critical for the IKs channel function. Identifying the Q1/E1 contact points here may provide new insights into how the IKs channel operates. We focus on Q1 position 145 and E1 positions 40–43. Replacing all native cysteine (Cys) in Q1 and introducing Cys into the above Q1 and E1 positions do not significantly perturb the Q1 channel function or Q1/E1 interactions. Immunoblot experiments on COS-7 cells reveal that Q1 145C can form disulfide bonds with E1 40C and 41C, but not E1 42C or 43C. Correspondingly, voltage clamp experiments in oocytes reveal that Q1 145C coexpressed with E1 40C or E1 41C manifests unique gating behavior and DTT sensitivity. Our data suggest that E1 40C and 41C come close to Q1 145C in the activated and resting states, respectively, to allow disulfide bond formation. These data and those in the literature lead us to propose a structural model for the Q1/E1 channel complex, in which E1 is located between S1, S4, and S6 of three separate Q1 subunits. We propose that E1 is not a passive partner of the Q1 channel, but instead can engage in molecular motions during IKs gating.
ERP SYSTEM IMPLEMENTATION: A MALAYSIAN PERSPECTIVE

Enterprise Resource Planning (ERP) systems are currently in high demand among Malaysian companies especially those in manufacturing and service based industries because it provides an effective management system leading to significant improvements in productivity. In this paper, a comprehensive study was done to identify the critical success factors and key benefits of ERP implementations using the responses from 151 firms. The importance of these factors was investigated within Malaysian companies using questionnaire survey method. The results of this study provide a practical guidance for the company owners, senior management and ERP consultants to be more efficient in managing the implementation of ERP with their limited resources.
(AA)AI More than the Sum of Its Parts

Recent thinking has it that AI, 25 years ago a unified field with a shared vision of creating intelligent machines, has devolved into a loosely connected set of distinct specialty areas with little communication or mutual interest between them. To the extent that this is true, it certainly appears to lessen the value of a centralized AI organization like AAAI and of traditional grand-scale AI conferences. But, I argue, the consequences are actually far worse: because of the very nature of intelligence, the centrifugal force on the field could thwart the very mission that drives it by leaving no place for the study of the interaction and synergy of the many coupled components that individually in isolation are not intelligent but, when working together, yield intelligent behavior. To raise awareness of the need to reintegrate AI, I contemplate the role of systems integration and the value and challenge of architecture. Illustrating some reason for optimism, I briefly outline some promising developments in large projects that are helping to increase the centripetal force on AI. I conclude by discussing how it is critical that the field focus its attention back on its original mission, led by a heavy dose of integrated systems thinking and grand challenges, and why after its first quarter century, AAAI is more essential than ever.