Miracle-dz/UniFAR-FTUs huggingface dataset:
Mar 06, 2020 Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6months of age is associated with elevated total-IgE and allergic rhinitis during the first

Background: Autoimmunity and allergy have been associated with decreased number and function of regulatory T-cells (Tregs) and low interleukin-2 (IL-2) levels. We aimed to investigate if the release of IL-2 from peripheral bloodmononuclearcells(PBMCs)stimulatedwith pathogenicairwaybacteriawasassociatedwithdevelopment of allergy-outcomes in early childhood. Methods: PBMCs were isolated at age 6 months in 331 infants from the Copenhagen Prospective Studies on Asthma in Childhood 2000 (COPSAC 2000 ) mother-child cohort, and subsequently stimulated with H. in ﬂ uenzae , M. catarrhalis and S. pneumoniae in in vitro cultures. Levels of cytokines (IL-2, IL-10, IFN- γ , TNF- α , IL-5, IL-13 and IL-17A) were determined in the supernatant by electrochemiluminescence immunoassays. The immune pro ﬁ les were analyzed for association with development of total-IgE, allergic sensitization and rhinitis during the ﬁ rst 7 years of life using regression models and principal component analysis (PCA). Findings: AnattenuatedIL-2responsetostimulationwith H.in ﬂ uenzae ( p =0 ∙ 011)and M.catarrhalis (p=0 ∙ 027) was associated with elevated total-IgE at age 7, which was con ﬁ rmed in a multivariate PCA model including all cytokine measurements (PC2, p = 0 ∙ 032). An immune pro ﬁ le with both reduced IL-2 and elevated IL-5 was as- sociated with increased risk of allergic rhinitis (PC3, p = 0 ∙ 038). We found no associations with development of allergic sensitization. Interpretation: A reduced IL-2 response from PBMCs exposed to common pathogenic airway bacteria at age 6monthswasassociatedwithelevatedtotal-IgEandallergicrhinitisduringthe ﬁ rst7yearsoflife.These ﬁ ndings suggestthatsuppressedTregactivityinearlylifemayheraldonsetofallergyinearlychildhood,whichcouldbea target for low-dose IL-2 trials in the future. Fund: COPSAC and public research funds all listed www.copsac. com. © CC (http:// creativecommons.org/licenses/by-nc-nd/4.0/). blood T cells was associated with decreased numbers of Tregs and increased risk of subsequent food allergy in the Barwon Infant study. Further, findings from a mouse model showedthatlow dose IL-2 treatment coulddampen theallergic in-flammatory process by inducing expansion and activation of Tregs. These findings suggest a potential application of low dose IL-2 therapy for prevention and treatment of childhood allergy, but further human studies are needed to disentangle the role of IL-2 expression in early life in relation to the development of allergic outcomes.
05 06 9 v 1 1 2 M ay 1 99 5 Discretized Light-Cone Quantization : Solving a 1 + 1 dimensional field theory ( QED )

We describe the programming method for generating the spectrum of bound states for relativistic quantum field theories using the nonperturbative Hamiltonian approach of Discretized Light-Cone Quantization. The method is intended for eventual application to quantum chromodynamics in 3+1 dimensions. Here the fundamental principles are illustrated concretely by treatment of QED in two dimensions. The code is intended as a basis for extensions to include more complicated gauge symmetry groups, such as SU(3) color, and other quantum numbers. The code was written in Fortran 77 and implemented on a DEC 5000-260 workstation with a typical runtime of 0.2s at total momentum 10.
in Computer

— Nowadays, Multimodal biometrics has created a substantial interest in the field of identification management due to higher recognition performance. This paper presents a comparative analysis of different fusion levels like feature level and score level in multimodal biometrics using fingerprint and face. Boolean function X-ORING has been used for fingerprint recognition, Fixed-keypoint-Scale Invariant Feature Transform (FSIFT) for feature reduction and face recognition. The multi-modular framework is intertwined utilizing match level combination at the confirmation stage on got coordinating score of face and unique finger impression. The execution of the biometric framework indicates change in the False Acceptance Rate (FAR) and False Reject Rate (FRR) . The proposed multi-modular framework accomplishes intriguing results with a few generally utilized databases.
in Computer

: The rapid development of wireless substance access suggests the requirement for substance placement and planning at wireless base stations. We examine a framework under which clients are separated into groups based on their channel conditions, and their solicitations are spoken to by various lines at logical front closures. Solicitations might be elastic (implying no hard delay constraint) or inelastic (requiring that a delay target be met). Correspondingly, we have demand lines that indicate the number of elastic solicitations, and shortage lines that indicate the deficiency in inelastic service. Caches are of limited size and can be revived periodically from a media vault. We consider two cost models that compare to inelastic solicitations for streaming put away substance and real-time streaming of occasions, separately. We plan provably optimal approaches that stabilize the solicitation lines (henceforth guaranteeing limited delays) and lessen average shortfall to zero [hence guaranteeing that the quality-of-service (QoS) target is met at small cost.
Internet X.509 Public Key Infrastructure Operational Protocols: FTP and HTTP

The protocol conventions described in this document satisfy some of the operational requirements of the Internet Public Key Infrastructure (PKI). This document specifies the conventions for using the File Transfer Protocol (FTP) and the Hypertext Transfer Protocol (HTTP) to obtain certificates and certificate revocation lists (CRLs) from PKI repositories. Additional mechanisms addressing PKIX operational requirements are specified in separate documents.
Diagnostic Delay in Rheumatoid Arthritis: A Qualitative Study of Symptom Interpretation Before the First Visit to the Doctor.

BACKGROUND To prevent joint damage among patients with rheumatoid arthritis (RA), there is a need to minimize delays from the onset of symptoms until the initiation of appropriate therapy. The present study explored the factors that have an impact on the time it takes for Danish patients with RA to approach their general practitioner (GP) with joint pain, and also how GPs respond to patients' complaints. METHODS The study was based on qualitative data collected using 11 semi-structured individual interviews. RESULTS When symptoms were obvious to patients, there was a shorter delay between symptom onset and contacting their GP. In cases where symptoms gradually worsened or were difficult to interpret, there was a longer delay. Participants with a high degree of body awareness appeared to be good at detecting when something was not normal, and they responded quickly to their symptoms. For those who regarded the doctor as a resource to which they were entitled and who were not worried about getting a diagnosis there was a shorter delay. Diffuse symptoms seemed to confuse GPs and can contribute to physician delay in the investigation process. Similarly, the presence of other diseases can result in a prolonged period before referral to a rheumatologist. CONCLUSIONS The nature and severity of symptoms are the deciding factors in their interpretation, by both the GP and the patient. Both the patient's disease recognition and his/her subsequent interaction with the doctor is influenced by the patient's body awareness and general attitude towards going to the doctor. The results showed that the greater the patient's body awareness, the better the disease recognition, the fewer barriers to contacting the GP and the shorter the delay in doing so. Copyright © 2015 John Wiley & Sons, Ltd.
2. Related Work

Octree Figure 2—Representation of regions using Octree. cation in the world. Specifically CarSpeak names a region by referring to the root of the region's sub-tree; it expresses the resolution of the region using the depth from the root of the region's sub-tree. The Octree also enables a car to store its data efficiently because, though the world is huge, each car needs to only expand the part of the Octree in its neighborhood. • How does the system allocate the wireless bandwidth to the most recent data from the region, given that multiple cars may sense the same region and each car does not know what information other cars know? CarSpeak adopts a content-centric MAC where information objects , as opposed to senders, contend for medium access. Further, each information object (i.e., 3D-point cloud stream) obtains a share of the medium proportional to the number of requests it receives. CarSpeak implements this abstraction using a distributed protocol , where nodes that sense a region contend on its behalf. Requests for region data are broadcast on the medium. Nodes compute a summary value of the quality of the information they have of each region (which is a measure of the timeliness and completeness of this information). CarSpeak uses a low overhead protocol to share this information among the nodes as annotations on their transmitted data packets. Each car uses these annotations to compute how much sensory data it should transmit so that its contribution to each stream is proportional to the completeness and freshness of the data it has from the corresponding region. CarSpeak then enforces this allocation by controlling the 802.11 contention window appropriately. • How does the system compress the redundancy in the transmitted sensor data while being resilient to packet loss? CarSpeak makes each packet self-contained by assigning it an independent set of branches in the Octree that are derived from the root. As a result, each received packet can be correctly inserted into the tree independent of other packets. CarSpeak also reduces the overlap between data transmitted by cars that sense the same region. Recall that each region is a cube that encompasses many smaller cubes, whose values keep changing in realtime due to the arrival of new sensor data. In CarSpeak even if multiple cars receive a request for the same region (i.e., the same encompassing cube), each of them will pick a different permutation according …
CarSpeak : a content-centric network for autonomous driving

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Building an Octree Octree Figure 2—Representation of regions using Octree. cation in the world. Specifically CarSpeak names a region by referring to the root of the region's sub-tree; it expresses the resolution of the region using the depth from the root of the region's sub-tree. The Octree also enables a car to store its data efficiently because, though the world is huge, each car needs to only expand the part of the Octree in its neighborhood. • How does the system allocate the wireless bandwidth to the most recent data from the region, given that multiple cars may sense the same region and each car does not know what information other cars know? CarSpeak adopts a content-centric MAC where information objects , as opposed to senders, contend for medium access. Further, each information object (i.e., 3D-point cloud stream) obtains a share of the medium proportional to the number of requests it receives. CarSpeak implements this abstraction using a distributed protocol , where nodes that sense a region contend on its behalf. Requests for region data are broadcast on the medium. Nodes compute a summary value of the quality of the information they have of each region (which is a measure of the timeliness and completeness of this information). CarSpeak uses a low overhead protocol to share this information among the nodes as annotations on their transmitted data packets. Each car uses these annotations to compute how much sensory data it should transmit so that its contribution to each stream is proportional to the completeness and freshness of the data it has from the corresponding region. CarSpeak then enforces this allocation by controlling the 802.11 contention window appropriately. • How does the system compress the redundancy in the transmitted sensor data while being resilient to packet loss? CarSpeak makes each packet self-contained by assigning it an independent set of branches in the Octree that are derived from the root. As a result, each received packet can be correctly inserted into the tree independent of other packets. CarSpeak also reduces the overlap between data transmitted by cars that sense the same region. Recall that each region is a cube that encompasses many smaller cubes, whose values keep changing in realtime due to the arrival of new sensor data. In CarSpeak even if multiple …
Acceptance of the Artificial Pancreas: Comparing the Effect of Technology Readiness, Product Characteristics and Social Influence between Invited and Self-Selected Respondents

• Human factors that may affect acceptance of artificial pancreas (AP) systems have been investigated in small samples of highly motivated, self-selected persons with type 1 diabetes (T1DM) with a focus on product characteristics. • A robust and standardized questionnaire to investigate the effect of human factors on AP acceptance is lacking. Aims • To investigate the impact of technology readiness, product characteristics and social influence on AP acceptance in a larger sample, including both self-selected and invited respondents with T1DM. • To develop a reliable and valid questionnaire. Baseline characteristics • The survey was completed by 425 self-selected persons (response rate: 69.7%) and 109 invited persons (response rate: 42.2%). • Compared to the self-selected respondents, the invited respondents were older, had diabetes for a longer period, were more satisfied with their treatment, perceived less frequently hyperglycemia and more often used insulin pump therapy.
A global genomic approach uncovers novel components for 1 twitching motility-mediated biofilm expansion in Pseudomonas 2 aeruginosa 3

24 Pseudomonas aeruginosa is an extremely successful pathogen able to cause both 25 acute and chronic infections in a range of hosts, utilizing a diverse arsenal of cell-associated 26 and secreted virulence factors. A major cell-associated virulence factor, the Type IV pilus 27 (T4P), is required for epithelial cell adherence and mediates a form of surface translocation 28 termed twitching motility, which is necessary to establish a mature biofilm and actively 29 expand these biofilms. P. aeruginosa twitching motility-mediated biofilm expansion is a 30 coordinated, multicellular behaviour, allowing cells to rapidly colonize surfaces, including 31 implanted medical devices. Although at least 44 proteins are known to be involved in the 32 biogenesis, assembly and regulation of the T4P, with additional regulatory components and 33 pathways implicated, it is unclear how these components and pathways interact to control 34 these processes. In the current study, we used a global genomics-based random-mutagenesis 35 technique, transposon directed insertion-site sequencing (TraDIS), coupled with a physical 36 segregation approach, to identify all genes implicated in twitching motility-mediated biofilm 37 expansion in P. aeruginosa . Our approach allowed identification of both known and novel 38 genes, providing new insight into the complex molecular network that regulates this process 39 in P. aeruginosa . Additionally, our data suggests a differential effect on twitching motility by 40 flagellum components based upon their cellular location. Overall the success of our TraDIS 41 approach supports the use of this global genomic technique for investigating virulence genes 42 in bacterial pathogens. 43
Neural activity in a hippocampus-like region of the teleost pallium is associated with active sensing and navigation

Most vertebrates use active sensing strategies for perception, cognition and control of motor activity. These strategies include directed body/sensor movements or increases in discrete sensory sampling events. The weakly electric fish, Gymnotus sp. , uses its active electric sense during navigation in the dark. Electric organ discharge rate undergoes transient increases during navigation to increase electrosensory sampling. Gymnotus also use stereotyped backward swimming as an important form of active sensing that brings objects toward the electroreceptor dense fovea-like head region. We wirelessly recorded neural activity from the pallium of freely swimming Gymnotus. Spiking activity was sparse and occurred only during swimming. Notably, most units tended to fire during backward swims and their activity was on average coupled to increases in sensory sampling. Our results provide the first characterization of neural activity in a hippocampal (CA3)-like region of a teleost fish brain and connects it to active sensing of spatial environmental features.
miR-152-3p Sensitizes Glioblastoma Cells Towards Cisplatin Via Regulation Of SOS1

Background: Accumulating evidences suggest that microRNAs (miRNAs) play key roles in mediating glioblastoma progression. Decreased expression of miR-152-3p was reported in several cancer types including glioblastoma. Methods: The sensitivity of glioblastoma cells to cisplatin was assessed by the cell counting kit-8 assay and ﬂ ow cytometry analysis. The expression of miR-152-3p was determined by RT-qPCR method. Bioinformatic analysis, dual luciferase reporter assay and Western blot were used to explore the target gene of miR-152-3p. The association between miR-152-3p and SOS1 was con ﬁ rmed in glioblastoma tissues by Pearson correlation analysis. Results: In the current study, we discovered that overexpression of miR-152-3p increased cisplatin sensitivity while inhibition of miR-152-3p decreased cisplatin sensitivity in glioblastoma cells (T98G and U87). In addition, miR-152-3p augmented cell apoptosis induced by cisplatin treatment. It was further predicted and validated that SOS1, a protein involved in regulating chemotherapy sensitivity, was a direct target gene of miR-152-3p. SOS1 was proven to suppress the cytotoxic effect of cisplatin in glioblastoma. Transfection of recombinant SOS1 could effectively reverse the increased cisplatin sensitivity induced by miR-152-3p overexpression in T98G. Furthermore, overexpression of SOS1 reduced the percentage of apoptotic cells increased by miR-152-3p mimic in the presence of cisplatin in T98G. More importantly, a signi ﬁ cant negative correlation between miR-152-3p levels and SOS1 levels was observed in glioblastoma tissues collected from 40 patients. Conclusion: Our study identi ﬁ ed miR-152-3p as a chemotherapy sensitizer in glioblastoma.
Honey Encryption Review

— Honey Encryption (HE) is a new encryption scheme that overcomes the weakness of traditional password-based encryption (PBE). It allows data to be encrypted using low min-entropy keys whilst delivering resilience against brute-force attacks. HE generates a ciphertext which, when decrypted with an invalid key, yields a plausible-looking but invalid plaintext referred to as a honey message. In this paper, we review the concept of Honey Objects, with a specific focus on the HE scheme. We investigate the current state of the art research in this field and look at practical applications which have been considered or developed thus far. Finally, we discuss the current limitations of HE and potential areas of interest for future research.
Semi-Automatic Building Extraction Utilizing QuickBird Imagery

Extraction of geospatial data from digital images is one of the most complex and challenging tasks faced by computer vision and photogrammetry communities. Geospatial data and buildings in particular are required for varieties of applications such as urban planning, creation of GIS databases, and urban city models. For decades, extraction of geospatial data in urban areas has been by conventional photogrammetry using aerial photos. This method is expensive, manually operated and require well-trained personnel. In recent years we have experienced the emergence of high-resolution space borne images, which have disclosed a large number of new opportunities for medium and large-scale topographic mapping. In this paper, we have developed a semi-automatic method to extract buildings in structured and unstructured urban settlements areas from high-spatial resolution panchromatic imagery. The proposed method uses radial casting algorithm to initialize snakes contours, and the fine measurements of building outlines is carried out using snakes model. The results are satisfactory with an extraction rate of 91 percent as demonstrated by examples over a variety of selected test areas. The potential, limitations and future work of our approach is discussed.
Low-Intensity Self-Management Intervention for Persons With Type 2 Diabetes Using a Mobile Phone-Based Diabetes Diary, With and Without Health Counseling and Motivational Interviewing: Protocol for a Randomized Controlled Trial

Background The present study protocol is designed to cover the Norwegian part of the European Union Collaborative Project—REgioNs of Europe WorkINg together for HEALTH (RENEWING HEALTH). Self-management support is an important element of care for persons with type 2 diabetes (T2D) for achieving metabolic control and positive lifestyle changes. Telemedicine (TM) with or without health counseling may become an important technological aid for self-management and may provide a user-centered model of care. In spite of many earlier studies on TM, there remains a lack of consensus in research findings about the effect of TM interventions. Objective The aim of RENEWING HEALTH is to validate and evaluate innovative TM tools on a large scale through a common evaluation, making it easier for decision makers to choose the most efficient and cost-effective technological interventions. The Norwegian pilot study evaluates whether the introduction of a mobile phone with a diabetes diary application together with health counseling intervention produces benefits in terms of the desired outcomes, as reflected in the hemoglobin A1c level, health-related quality of life, behavior change, and cost-effectiveness. Methods The present study has a mixed-method design comprising a three-armed prospective randomized controlled trial and qualitative interviews with study data collected at three time points: baseline, after 4 months, and after 1 year. The patients’ registrations on the application are recorded continuously and are sent securely to a server. Results The inclusion of patients started in March 2011, and 100% of the planned sample size is included (N=151). Of all the participants, 26/151 patients (17.2%) are lost to follow-up by now, and 11/151 patients (7.3%) are still in the trial. Results of the study protocol will be presented in 2014. Conclusions The key goals of this trial are to investigate the effect of an electronic diabetes diary app with and without health counseling, and to determine whether health counseling is important to the continued use of the application and the patients’ health competence and acceptability. Research within this area is needed because few studies have investigated the effectiveness of apps used in long-term interventions with this degree of self-management. Trial Registration Clinicaltrials.gov NCT01315756; http://clinicaltrials.gov/ct2/show/NCT01315756 (Archived by WebCite at http://www.webcitation/6BTyuRMpH).