Miracle-dz/UniFAR-FTUs huggingface dataset:
HAMA: A Three-Layered Architecture for Integrating Object Tracking and Location Management in Wireless Sensor Networks

Recently, with the rapid development of microprocessor and wireless communication technologies,wireless sensors have become more popular in academic and industrial communities.The sensor network is used to be the interface between information systems and users in the real world, and sensors that support object tracking functions would broaden the types of sensor applications. In this paper, we propose an three-layered architecture, Hierarchical Alert Model Architecture (HAMA), to provide a complete solution to the problem.In the first layer, the object tracking server (OTS), is used to maintain the object locations with less precision due to the reduction of the communication for location updates.In the second layer, the tracking alert model is designed to assist the object tracking server (OTS), to manage all moving objects with higher precision in the sensor network.In the third layer, the sensing alert model is designed to assist the sensor nodes for tracking irregular movement objects.We then conduct experiments for verifying the performance of HAMA.The experimental results show that HAMA has superior performance in tracking and management of moving objects.
Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

Rationale: FK506-binding proteins FKBP12.6 and FKBP12 are associated with cardiac ryanodine receptors (RyR2), and cAMP-dependent protein kinase A (PKA)-dependent phosphorylation of RyR2 was proposed to interrupt FKBP12.6-RyR2 association and activate RyR2. However, the function of FKBP12.6/12 and role of PKA phosphorylation in cardiac myocytes are controversial. Objective: To directly measure in situ binding of FKBP12.6/12 to RyR2 in ventricular myocytes, with simultaneous Ca sparks measurements as a RyR2 functional index. Methods and Results: We used permeabilized rat and mouse ventricular myocytes, and fluorescently-labeled FKBP12.6/12. Both FKBP12.6 and FKBP12 concentrate at Z-lines, consistent with RyR2 and Ca spark initiation sites. However, only FKBP12.6 inhibits resting RyR2 activity. Assessment of fluorescent FKBP binding in myocyte revealed a high FKBP12.6-RyR2 affinity (Kd=0.7±0.1 nmol/L) and much lower FKBP12-RyR2 affinity (Kd=206±70 nmol/L). Fluorescence recovery after photobleach confirmed this Kd difference and showed that it is mediated by koff. RyR2 phosphorylation by PKA did not alter binding kinetics or affinity of FKBP12.6/12 for RyR2. Using quantitative immunoblots, we determined endogenous [FKBP12] in intact myocytes is ≈1 &mgr;mol/L (similar to [RyR]), whereas [FKBP12.6] is ≤150 nmol/L. Conclusions: Only 10% to 20% of endogenous myocyte RyR2s have FKBP12.6 associated, but virtually all myocyte FKBP12.6 is RyR2-bound (because of very high affinity). FKBP12.6 but not FKBP12 inhibits basal RyR2 activity. PKA-dependent RyR2 phosphorylation has no significant effect on binding of either FKBP12 or 12.6 to RyR2 in myocytes.
Algebraic Methods for Log-Linear Models

Techniques from representation theory (Diaconis, 1988) and algebraic geometry (Drton et al., 2008) have been applied to the statistical analysis of discrete data with log-linear models. With these ideas in mind, we discuss the selection of sparse log-linear models, especially for binary data and data on other structured sample spaces. When a sample space and its symmetry group satisfy certain conditions, we construct a natural spanning set for the space of functions on the sample space which respects the isotypic decomposition; these vectors may be used in algorithms for model selection. The construction is explicitly carried out for the case of binary data.
Double-blind prospective randomized study comparing topical mupirocin and placebo for the prevention of infection associated with central venous catheters.

OBJECTIVE To compare the incidence of exit site colonization, local catheter-related infection and catheter-related bacteremia in patients randomized to receive either topical 2% mupirocin or placebo at the catheter exit site. PATIENTS AND METHODS Patients requiring central venous catheters for more than three days were randomized to receive in a double-blind fashion either topical mupirocin or an identical placebo at the exit site three times weekly at the time of dressing change. Insertion, site care and removal of catheters were standardized. Serial semiquantitataive cultures of the skin at the catheter insertion site were performed using a sterile 25 cm(2) template. The distal and proximal catheter segments were cultured using a standardized semiquantitative technique, and any suspect catheter-related bacteremia was investigated with two sets of peripheral blood cultures, a 10 mL sample of infusate and clinical assessment. Both univariate and multivariate analyses were conducted on individual risk factors to determine factors that might influence the outcomes of local or systemic catheter-related infection. RESULTS Local catheter-related infection (defined as more than 15 colony forming units [cfu] on culture of the proximal or distal catheter segment) occurred in six of 57 (10.5%) in the mupirocin group versus 18 of 69 (26%) in the placebo group (P<0.05) for the distal catheter segments and in one of 40 (2.5%) versus 13 of 47 (27.6%) for the proximal segments in the mupirocin and placebo groups (P<0.006), respectively. Catheter-related bacteremia occurred in one of 57 (1.8%) of the mupirocin group but in five of 69 (7.2%) of the placebo group (P=0.15). Stepwise logistic regression revealed that cutaneous colonization at the insertion site of at least 10(3) cfu/mL/25 cm(2) (OR 2.6; CI 1.0 to 6.9) and the use of placebo (OR 3.3; CI 1.2 to 9.0) were significant factors predicting local catheter-related infection; whereas mupirocin was associated with reciprocal protective effect (OR 0.3; 95% CI 0.1 to 0.8). CONCLUSIONS These findings suggest that patients receiving topical mupirocin at the exit site for long term central venous catheters have significantly less local catheter-related infection, and there is a trend towards less catheter-related bacteremia.
A Common Ground for Virtual Humans: Using an Ontology in a Natural Language Oriented Virtual Human Architecture

When dealing with large, distributed systems that use state-of-the-art components, individual components are usually developed in parallel. As development continues, the decoupling invariably leads to a mismatch between how these components internally represent concepts and how they communicate these representations to other components: representations can get out of synch, contain localized errors, or become manageable only by a small group of experts for each module. In this paper, we describe the use of an ontology as part of a complex distributed virtual human architecture in order to enable better communication between modules while improving the overall flexibility needed to change or extend the system. We focus on the natural language understanding capabilities of this architecture and the relationship between language and concepts within the entire system in general and the ontology in particular.
The Creation of Knowledge Innovation System

Knowledge innovation system is a hot theoretical and practical issue in recent years. Academic theory of knowledge innovation system obviously lags behind the objective facts of the construction of the knowledge innovation system in China. Based on the Science and education integration of SECI (SEI-SECI) model, this paper reveals that the science and education integration to promote the structural completeness and degree of knowledge innovation spiral ascending mechanism. This paper intends to use a new angle and way to improve the existing knowledge innovation system of research.
Effect of Telephone-Based Support on Postpartum Depression: A Randomized Controlled Trial

Background Postpartum depression (PPD) is one public health issue that affects both maternal and child health. This research studies the effect of health volunteers’ telephone- based support on decreasing PPD. Materials and Methods This randomized controlled trial evaluated 203 women who had uncomplicated deliveries. The women completed the Edinburg Postnatal Depres- sion Scale (EPDS), 10 to 15 days after childbirth in order to be assessed for pre-trial depression scores. The cut-off point for depression was considered to be a score of >10. We randomly assigned 54 eligible mothers (n=27 per group) with mild and moderate de- pression to the intervention and control groups. In both groups, mothers received routine postpartum care. The intervention group additionally received telephone support from health volunteers. A questionnaire was used to gather demographic and obstetric infor- mation. By the end of the 6thweek, mothers completed the EPDS to be reassessed for depression after intervention. Data were analyzed using the chi-square, Fisher’s exact, t- and paired t tests. Results The mean depression scores before intervention (10 to 15 days after childbirth) in the intervention and control groups did not significantly differ (P=0.682). Depres- sion scores of the intervention and control groups showed a significant difference after 6 weeks (P=0.035). In addition, there was a significant decrease in depression for the intervention and control groups (P=0.045). Conclusion Health volunteer telephone-based support effectively decreased PPD and may be beneficial to women with symptoms of mild and moderate PPD (Registration number: IRCT201202159027N1).
Diffuse large B‐cell lymphoma showing an interfollicular pattern of proliferation: a study of the Osaka Lymphoma Study Group

Aims: Diffuse large B‐cell lymphoma (DLBCL) usually proliferates effacing lymph follicles. In occasional cases, tumour cells show an interfollicular pattern of proliferation preserving lymph follicles. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to determine whether this type of lymphoma is a distinct entity of DLBCL.
Inhomogeneous disappearance of myofilament-related cytoskeletal proteins in stunned myocardium of guinea pig.

The decrease in Ca2+ responsiveness of myofilaments in stunned myocardium implies that there may be structural changes in proteins composing the contractile machinery. To elucidate the lesion in stunned myocardium, isolated guinea pig hearts were subjected to global ischemia at 37 degrees C and reperfused. SDS-PAGE revealed that the contents of desmin, alpha-actinin, and spectrin decreased in the myofibrillar fraction isolated from hearts reperfused after 60-minute ischemia compared with nonischemic control hearts. To examine the change of cytoskeletal proteins in stunned myocardium, immunohistochemical studies with antibodies against these proteins were performed after 15 minutes of ischemia. In stunned myocardium, the staining was largely intact, but there were some lesions where desmin was not stained and alpha-actinin and spectrin were only weakly identified. The percentage of normally stained areas in the myocardium (percent stained area), quantified by image processing, was significantly lower in stunned myocardium (79.6 +/- 3.6%, mean +/- SEM) than in nonischemic control myocardium (96.5 +/- 0.7%). Percent recovery of developed pressure significantly correlated with percent stained area (r = .82, P < .001). In hearts subjected to 15-minute ischemia but not reperfused, or in hearts reperfused with Ca(2+)-free solution after 15-minute ischemia, staining by the antibodies remained intact, suggesting that the change of the cytoskeletal proteins is mediated by Ca2+ overload during reperfusion. In hearts treated with the protease inhibitor leupeptin (50 mumol/L) or calpain inhibitor I (100 mumol/L), both developed pressure and staining were well preserved. These results indicate that contractile dysfunction in stunned myocardium has a strong correlation with the disappearance of cytoskeletal proteins that may be mediated by a Ca(2+)-dependent intracellular protease activated during reperfusion. The disruption of cytoskeletal proteins is a possible mechanism for stunning, although it may be a secondary effect of protease activation.
Taste Bud-Derived BDNF Is Required to Maintain Normal Amounts of Innervation to Adult Taste Buds

Abstract Gustatory neurons transmit chemical information from taste receptor cells, which reside in taste buds in the oral cavity, to the brain. As adult taste receptor cells are renewed at a constant rate, nerve fibers must reconnect with new taste receptor cells as they arise. Therefore, the maintenance of gustatory innervation to the taste bud is an active process. Understanding how this process is regulated is a fundamental concern of gustatory system biology. We speculated that because brain-derived neurotrophic factor (BDNF) is required for taste bud innervation during development, it might function to maintain innervation during adulthood. If so, taste buds should lose innervation when Bdnf is deleted in adult mice. To test this idea, we first removed Bdnf from all cells in adulthood using transgenic mice with inducible CreERT2 under the control of the Ubiquitin promoter. When Bdnf was removed, approximately one-half of the innervation to taste buds was lost, and taste buds became smaller because of the loss of taste bud cells. Individual taste buds varied in the amount of innervation each lost, and those that lost the most innervation also lost the most taste bud cells. We then tested the idea that that the taste bud was the source of this BDNF by reducing Bdnf levels specifically in the lingual epithelium and taste buds. Taste buds were confirmed as the source of BDNF regulating innervation. We conclude that BDNF expressed in taste receptor cells is required to maintain normal levels of innervation in adulthood.
Time Complexity of Motion Planning Algorithm for Homogeneous Combinatorial Robots

Some properties and an algorithm of the motion planning problem of homogeneous combinatorial robots are presented. Homogeneous combinatorial robots can be combined and separated freely in the process of moving. The motion planning problem of homogeneous combinatorial robots in a static discrete environment is proven to be compliant to the principle of optimality. A backward dynamic motion planning algorithm is used to find the optimal motion plans. Suppose that |V| is the number of all vertices in the graph, n is the number of robots, and k is the number of stages robots passing the graph. The time complexity without considering the limitation function of this problem is O(|V|2nk ). Furthermore, the time complexity with the limitation function of the problem is presented
Comparable efficacy and safety of insulin glulisine and insulin lispro when given as part of a Basal-bolus insulin regimen in a 26-week trial in pediatric patients with type 1 diabetes.

BACKGROUND We compared the efficacy and safety of insulin glulisine with insulin lispro as part of a basal-bolus regimen in children and adolescents with type 1 diabetes. METHODS Overall, 572 children and adolescents (4-17 years old) using insulin glargine or neutral protamine Hagedorn insulin as basal insulin were enrolled in a 26-week, multicenter, open, centrally randomized, parallel-group, noninferiority study. Subjects were randomized to receive glulisine (n = 277) or lispro (n= 295) 0-15 min premeal. RESULTS Baseline-to-endpoint hemoglobin A1c changes were similar between the two insulins: adjusted mean change (glulisine vs. lispro), 0.10% versus 0.16%; between-treatment difference (glulisine-lispro), &minsu;0.06, 95% confidence interval (-0.24; 0.12); and prespecified noninferiority margin, 0.4%. Overall, for all age groups together, the percentage of patients achieving American Diabetes Association age-specific A1c targets at endpoint was significantly higher (P = 0.039) with glulisine (38.4%) versus lispro (32.0%). From Month 4 to endpoint, both "all" and "severe" symptomatic hypoglycemia rates were similar (3.10 vs. 2.91 and 0.06 vs. 0.07 events/patient-month, respectively). Frequency and type of adverse events, serious adverse events, or hypoglycemia reported as serious adverse events were similar between both groups. CONCLUSIONS Glulisine was as effective as lispro in baseline-to-endpoint A1c change, and both treatments were similarly well tolerated.
The Distributional Consequences of Large Devaluations

We study the differential impact of large exchange rate devaluations on the cost of living at different points on the income distribution. Across product categories, the poor have relatively high expenditure shares in tradeable products. Within tradeable product categories, the poor consume lower-priced varieties. Changes in the relative price of tradeables and the relative prices of lower-priced varieties following a devaluation will affect the cost of the consumption basket of the low-income households relative that of the high-income households. We quantify these effects following the 1994 Mexican peso devaluation and show that their distributional consequences can be large. In the two years that follow the devaluation, the cost of the consumption basket of those in the bottom decile of the income distribution rose between 1.46 and 1.6 times more than the cost of the consumption basket for the top income decile.
Towards steganography detection through network traffic visualisation

The paper presents initial step toward new network anomaly detection method that is based on traffic visualisation. The key design principle of the proposed approach is the lack of direct, linear time dependencies for the created network traffic visualisations. The method's feasibility is demonstrated in network steganography environment by presenting steg-tomography methodology and developing the dedicated visualisation tool. To authors' best knowledge this is the first utilization of network traffic visualisations for steganalysis purposes.
The Economic Benefits of Snowmobiling to Wyoming Residents: A Travel Cost Approach with Market Segmentation

Little research has been done on the economic benefits of snowmobiling. This study uses cluster analysis to identify different snowmobiler segments, and then uses the travel cost method to estimate the respective consumer surplus values for the pooled sample and the different market segments. Consumer surplus per trip for the pooled sample is $68 and for the different market segments ranged from $31 to $101 per trip. Differences between the pooled model and segments highlight the importance of differentiating recreational users for both management related issues and for economic benefit measurements.
The effects of the NMR shift-reagents Dy(PPP)2, Dy(TTHA) and Tm(DOTP) on developed pressure in isolated perfused rat hearts. The role of shift-reagent calcium complexes.

The 23Na NMR shift-reagent complexes (Dy(PPP)2, Dy(TTHA), and Tm(DOTP)) bind stoichiometric amounts of Ca2+. Thus, in perfused rat heart systems, a supplementation of Ca2+ is required to maintain the requisite extracellular free calcium concentration ([Ca(o)]f) and to approximate a physiological level of contractile function. The amount of reagent-bound Ca2+ in a heart perfusate that contains a shift-reagent depends on: (1) Ca2+ binding by excess ligand used during the preparation of the shift-reagent; and (2) the Ca2+ binding affinity of the shift-reagent. To address point 1), we introduced a 1H and 31P NMR spectroscopic titration method to quantify directly the concentration of the excess ligand. We also used this method to minimize the amount of excess ligand (L) and thus the amount of Ca*L complex. To address point (2), we determined the stepwise Kd (microm) values of the Ca complexes of the three shift-reagents. : Dy(PPP)2, Kd=0.09, Kd2=7.9; Dy(TTHA), Kd1=10.66, Kd2=10.12; and Tm(DOTP), K(d1)=0.502, Kd2=4.98. The Kd values of the Ca complexes of the phosphonate and triphosphate based shift-reagents, Tm(DOTP) and Dy(PPP)2, respectively, are lower than those of the polyaminocarboxylate-based Dy(TTHA), indicating stronger Ca binding affinities for the former two types of complexes. We have also shown a positive correlation between [Ca(o)]f and left ventricular developed pressure (LVDP) in perfused rat hearts. Dy(TTHA) has shown no effect on LVDP v[Ca(o)]f. The LVDP values in the presence of the phosphonate and triphosphate based shift-reagents, however, were significantly higher than expected from the [Ca(o)]f levels alone. Thus a positive inotropic effect, independent of [Ca(o)]f, is evident in the presence of Tm(DOTP) or Dy(PPP)2.
Dealing with Software Model Quality in Practice: Experience in a Research Project

Although past research has resulted in different means to deal with software model quality, creation of adequate software models remains challenging. Any modelling effort must be carefully analysed and planned before it starts, and definition or adoption of modelling guidelines is usually necessary. In addition, the amount of publications addressing model quality in practice is low, and the knowledge about others' experience regarding model quality is limited. This paper reports on our experience in dealing with software model quality in the context of a project between industry and academia. Such a project corresponds to a large-scale research project in which modelling has been used both as part of the necessary work for executing the project and for creating project results. We present how we have dealt with model quality in requirements modelling and in conceptual model specification, as well as a set of lessons learned. The insights provided can help both researchers and practitioners when having to deal with software model quality.
On the Number of Linear Extensions of Graphs Annie Hu under the direction of Mr

Given a bipartite graph, let us pick an acyclic orientation of its edges. Then, if we consider the partially ordered set (poset) induced by this orientation, the number of linear extensions of such a poset is maximal whenever the orientation is bipartite, or such that no directed path of length two exists. We define a sequence of automorphisms that injectively but nonbijectively map the set of linear extensions of a nonbipartite orientation to the set of linear extensions of a bipartite orientation. Additionally, we define such a sequence for simple odd cycle graphs and discuss extending mappings to apply to general nonbipartite graphs.
Morpheus 2.0: A Data Transformation Management System

The authors have previously built the Morpheus Data transformation system. Based on feedback from demo-ing the system at SIGMOD 2006 as well as to numerous CIO’s and researchers at IBM and Microsoft, we have completely redesigned the system to facilitate a state-based browsing paradigm, the ability to filter transforms based on lineage and input-output properties and best-fit search for composite transforms. Also included is a novel crawler to search for transforms of interest either within an enterprise or across the web. The result is Morpheus 2.0, which is now operational, and is described in this paper.
Frequency and avidity of specific antigen-binding cells in developing mice

In order to analyze the development of antibody diversity in which the genes coding for the antigen-specific cells we have compared the binding of diverse antigens by cells in the fetal, neonatal, and adult mouse. Although the numbers of antigen-binding cells present in fetuses and young animals were smaller than in adults, no restriction could be detected in the varity of specificities expressed in the fetuses, either with respect to the kinds of antigens bound, or to the range of avidities of binding. Cells specific for each of the 11 antigens tested could be detected in the fetus only in the last 4 days before birth, at which time they appeared both in the liver and in the spleen. In all cases, these cells disappeared both in the liver and in the spleen. In all cases, these cells disappeared from the liver within a day of birth, but continued to increase in number in the spleen until adulthood.