Miracle-dz/UniFAR-FTUs huggingface dataset:
low levels of tumor suppressor candidate 3 predict poor prognosis of patients with hepatocellular carcinoma

Purpose: The tumor suppressor candidate 3 ( TUSC3 ) has been considered to be closely associated with the occurrence, development and invasion of various malignant tumors. How-ever, the expression of TUSC3 in hepatocellular carcinoma (HCC) tissues remains ambiguous. The purpose of this research was to investigate the expression of TUSC3 in HCC tissues and analyze the relationship between TUSC3 levels and clinicopathological characteristics and prognosis of HCC patients. Materials and methods: Immunohistochemistry was used to detect the expression of TUSC3 in HCC and the corresponding para-cancerous tissues from 92 samples of HCC patients. mRNA and protein expression levels of TUSC3 were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays in 25 paired HCC and corresponding adjacent nontumor tissues. Furthermore, statistical analysis was applied to evaluate the correlation between TUSC3 level and the clinicopathological features and prognosis of HCC patients. Results: Immunohistochemical assay indicated that the expression of TUSC3 was significantly lower in HCC tissues when compared with the corresponding para-cancerous tissues ( χ 2 = 11.512, P = 0.001). The analysis of clinicopathological characteristics showed that low expression of TUSC3 in HCC tissues was significantly associated with Edmondson grade, Barcelona Clinic Liver Cancer stage and tumor size ( P = 0.008, 0.009 and 0.020, respectively). Univariate analysis showed that the expression of TUSC3 was strongly correlated with overall survival (OS) and disease-free survival (DFS) after radical surgery in HCC patients ( P , 0.001, P , 0.001, respec-tively). Multivariate analysis revealed that the TUSC3 level was an independent risk factor for OS and DFS in HCC patients ( P = 0.001, P , 0.001, respectively). Results of qRT-PCR and Western blot assays indicated that the level of TUSC3 in HCC tissues was significantly lower than that in the corresponding adjacent noncancerous tissues ( P , 0.01, P , 0.001). Conclusion: The expression of TUSC3 in HCC was significantly downregulated and was correlated with tumor progression and prognosis, which could be used as an independent predictor of prognosis in HCC patients.
A Survey on Speech Emotion Recognition in Human Computer Interaction

— n Human Computer Interaction(HCI), emotion recognition from the speech signal has been research topic from many years Speech emotion recognition is one of the recent challenges in speech processing and Human Machine Interaction in order to address various operational needs for the real world applications. To identify the emotions from the speech signal, many systems have been developed. In this paper speech emotion recognition based on the previous technologies which uses different classifiers for the emotion recognition is reviewed. The classifiers are used to differentiate emotions such as anger, happiness, sadness, surprise, neutral state, etc. The database for the speech emotion recognition system is the emotional speech samples and the features extracted from these speech samples are the energy, pitch, linear prediction cepstrum coefficient (LPCC), Mel frequency cepstrum coefficient (MFCC). The classification performance is based on extracted features
Machine Learning-based Modeling of Olfactory Receptors: Human OR51E2 as a Case Study

Atomistic-level investigation of olfactory receptors (ORs) is a challenging task due to the experimental/computational difficulties in the structural determination/prediction for members of this family of G-protein coupled receptors. Here we have developed a protocol that performs a series of molecular dynamics simulations from a set of structures predicted de novo by recent machine learning algorithms and apply it to a well-studied receptor, the human OR51E2. Our study demonstrates the need for extensive simulations to refine and validate such models. Furthermore, we demonstrate the need for the sodium ion at a binding site near D 2.50 and E 3.39 to stabilize the inactive state of the receptor. Considering the conservation of these two acidic residues across human ORs, we surmise this requirement also applies to the other ∼ 400 members of this family.
West Virginia's Forests 2008

The first full annual inventory of West Virginia's forests reports 12.0 million acres of forest land or 78 percent of the State's land area. The area of forest land has changed little since 2000. Of this land, 7.2 million acres (60 percent) are held by family forest owners. The current growing-stock inventory is 25 billion cubic feet--12 percent more than in 2000--and averages 2,136 cubic feet per acre. Yellow-poplar continues to lead in volume followed by white and chestnut oaks. Since 2000, the saw log portion of growing-stock volume has increased by 23 percent to 88 billion board feet. In the latest inventory, net growth exceeded removals for all major species. Detailed information on forest inventory methods and data quality estimates is included in a DVD at the back of this report. Tables of population estimates and a glossary are also included.
Design Guidance for Channelized Right-Turn Lanes

This report documents and presents the results of research to develop design guidance for channelized right-turn lanes. Observational field studies were conducted at 35 intersection approaches in cities to assess pedestrian crossing behavior, motorist yield behavior, and the interaction between pedestrians and motor vehicles at channelized right-turn lanes. Simulation modeling was performed to quantify the traffic operational benefits of channelized right-turn lanes with various types of traffic control and to compare the delay reduction of channelized right-turn lanes and conventional right-turn lanes. Crash data for nearly 400 intersection approaches in Toronto, Ontario, Canada, including intersection approaches with channelized right-turn lanes, conventional right-turn lanes, and shared through/right-turn lanes, were analyzed to compare the safety performance of the three right-turn treatment types. The research results indicate that channelized right-turn lanes have a definite role in improving operations and safety at intersections. However, to achieve these benefits they should have consistent design and traffic control and should be used at appropriate locations. The research provides design guidance for channelized right-turn lanes that addresses geometric elements such as crosswalk location, special crosswalk signing and marking, island type, radius of turning roadway, angle of intersection with cross street, acceleration and deceleration lanes, and traffic control.
On Modeling Household Labor Supply with Taxation

On Modeling Household Labor Supply with Taxation Discrete-choice models provide a simple way of representing utility-maximizing labor supply decisions in the presence of highly nonlinear and possibly non-convex budget constraints. Thus, it is not surprising that they are so extensively used for ex-ante evaluation of taxbenefit reforms. The question asked in this paper is whether it is possible and desirable to get still more flexibility by relaxing some of the usual constraints imposed on household preferences and rationality. We first suggest a model which attains flexibility by making parameters vary freely across hours choices. By embedding the traditional structural approach in this specification, it is shown that the restrictions on underlying well-behaved leisure-consumption preferences are rejected. More fundamentally still, the standard approach, i.e., the assumption of unitary households optimizing statically, is strongly rejected when tested against a general model with priceand income-dependent preferences. In a static environment, the result boils down to a rejection of the unitary model. Interestingly, restrictions from both structural and standard models also imply important discrepancies in estimated elasticities and simulated predictions of responses to a tax reform. In particular, large differences appear between standard models and the general model which possibly encompasses several interpretations including dynamic aspects and intrahousehold negotiation. These findings illustrate the difficulty to conduct policy analysis in a way which reconciles the best explanatory power and a framework consistent with economic theory. The general model we suggest may provide future research with an interesting setting to test some of the dimensions of household behavior. JEL Classification: C25, C52, H31, J22
Main Text

1Epigenetics & Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. 2Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. 3School of Mathematics and Statistics, University of Sydney, Sydney, NSW 2006, Australia 4Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia. 5Institute of Human Genetics, CNRS, University of Montpellier, Montpellier, France. 6Lead Contact
An evaluation scheme for database management systems that are claimed to be relational

This article offers basic principles for use in determining how "relational" a DBMS product is — a challenge which faces many buyers today, because almost every vendor is claiming that his DBMS product is "relational". The material is likely to be of interest to vendors also. Some of them may not realize how far from the mark they are.
Variability of surface air temperature in Tampico, northeastern Mexico

Herein, we present an analysis of the variability of surface air temperature at Tampico in the southern coast of Tamaulipas, northeastern Mexico, during the period 1961–2009. Several indices were used for the analysis which include the yearly highest and lowest records of maximum and minimum daily temperatures, the start and duration of the annual warm period, the temperature of the yearly warmest month, and the annual thermal oscillation. Linear trends indicate that winter temperatures are increasing (roughly 1 °C decade−1), whereas summer temperatures have remained practically unchanged. The annual warm period starts on days 83–108 of every year and lasts 180–240 days, but there is also an apparent periodicity of 15–18 years in the occurrence of the shortest warm periods. After mid‐1970s, the warm periods have decreased roughly 6 days per decade, but the temperature of the annual warmest month has increased roughly 0.50 °C decade−1, this indicates that warm periods (spring–summer) are becoming shorter but warmer. Large‐scale climatic patterns also affect the low‐frequency thermal variability at Tampico: the Atlantic Multidecadal Oscillation modulates the summer temperature, while El Niño variability modulates a fraction of the annual thermal oscillation via mainly delayed signals passing through the Caribbean. The higher frequency variability observed as numerous anomalous years in the temperature series may be explained mostly by dynamical factors such as a decreased southerly heat flux and/or an increased northerly heat flux (like in the year 1974), or a reduction of the annual warm period and precipitation in the northeastern Mexican coast associated with the El Niño activity (like in the year 1998). However, some cold periods may be attributable to vulcanic eruptions like those of the Chichonal (in Mexico) and the Pinatubo (in Philippines).
Profiles of Irish Survivors of Institutional Abuse with Different Adult Attachment Styles

The UCD community has made this article openly available. Please share how this access benefits you. Your story matters! (@ucd_oa) Some rights reserved. For more information, please see the item record link above. Acknowledgements. This study was funded by a grant from the Commission to Inquire into Child Abuse. Thanks to the interviewing team; colleagues at the NCS in Ireland and ICAP in the UK for clinical support; colleagues at psychology departments at UCL, MMU, University of Aberdeen who provided interviewing facilities in the UK; colleagues at Right of Place, Aisling, and the London-Irish centre for expert advice on survivor issues; Muriel Keegan for administrative support; Fred Lowe for liaison at CICA; and all participants for their generosity in taking part in the study. Two hundred and forty seven survivors of institutional abuse in Ireland were classified with the Experiences in Close Relationships Inventory as having fearful (44%), preoccupied (13%), dismissive (27%) or secure (17%) adult attachment styles. The group with the secure adult attachment style had the most positive profile, while the most negative profile occurred for the fearful group in terms of DSM IV diagnoses and scores on the Trauma Organization Quality of Life 100 scale, and the Kansas Marital Satisfaction Scale. The profile of the preoccupied group was more similar to that of the fearful group. The profile of the dismissive group was more similar to that of the secure group.
Jetstream—Early operations performance, adoption, and impacts

Jetstream is a first of its kind system for the NSF — a distributed production cloud resource. We review the purpose for creating Jetstream, discuss Jetstream's key characteristics, describe our experiences from the first year of maintaining an OpenStack‐based cloud environment, and share some of the early scientific impacts achieved by Jetstream users. Jetstream offers a unique capability within the XSEDE‐supported US national cyberinfrastructure, delivering interactive virtual machines (VMs) via the Atmosphere interface. As a multi‐region deployment that operates as an integrated system, Jetstream is proving effective in supporting modes and disciplines of research traditionally underrepresented on larger XSEDE‐supported clusters and supercomputers. Already, Jetstream has been used to perform research and education in biology, biochemistry, atmospheric science, earth science, and computer science.
The effect of stress, pore fluid and pore structure on elastic wave velocities in sandstones

A model of elastic wave propagation in fluid-saturated sandstones is developed that takes into account pore fluid properties, and stress. It is based on the assumption that the pore space can be represented by a distribution of crack-like spheroidal pores having a distribution of aspect ratios, and a single family of non-closable spheroidal pores. The Eshelby-Wu formalism is used to find exact expressions for the bulk and shear compliances of the pores. Asymptotic analytical expressions are obtained for the compliances of both dry and fluidsaturated spheroidal pores that are crack-like, needle-like, or nearly spherical. These expressions are incorporated into two commonly used effective medium theories, the Mori-Tanaka and the Differential schemes, to obtain expressions for the effective elastic properties of dry and fluid-saturated rocks containing spheroids of a given aspect ratio, as a function of porosity or crack density. The stress dependence of the elastic velocities is modelled by considering that the elastic moduli vary with stress due to crack closure. This pore structure model is able to explain successfully the pressure dependence of ultrasonic dry velocities on many sets of laboratory data. Predictions of saturated velocities are made using either the Gassmann equation, or using an effective medium theory in conjunction with the aspect ratio distribution found from the dry data. For ultrasonic velocities obtained at high frequencies (MHz), the predictions of effective medium theories are more accurate than the Gassmann predictions. Low-frequency measurements (0.02 Hz) of the bulk modulus were obtained on Fontainebleau sandstone, under pressure, and with different pore fluids. For water and glycerin-saturated samples, both the 4% and 13% porosity rock specimens were more compliant at low frequencies than at high frequencies. Finally, a model is proposed for the frequency dependence of the wave velocities, assuming that at a given frequency, some pores obey the Gassmann equation, and others are isolated, with a critical aspect ratio demarcating the two families that depends on frequency and fluid viscosity.
Scientometric Analysis of Circular Innovation: A Novel Approach for Sustainability

: This paper aimed to explore the current research trends in circular innovation (CI) through scientometric analysis of data, acquired from the Web of Science (WoS) database, using the VOSviewer program. By applying some filters to draw boundaries, this paper found 917 journal articles related to CI in the Social Sciences Citation Index. Tables and maps were used to visualize and illustrate the keywords occurrence, leading journals, authors, and countries that made the greatest contribution to the research field. As the first scientometric analysis of CI research, this paper provided an up-to-date and inclusive big picture of related literature, indicating its unique and primary value. In addition, this paper understood and visualized research patterns and trends and identified main topics, countries and journals, which added value to the innovation and sustainability literature. The research results showed that the number of citations and publications about CI increased rapidly after 2010, and the most prominent issues related to CI were circular economy (CE), circular business models, sustainability, and sustainable development. Finally, the paper presented future research directions of CI linked to business management.
Patient Safety during Propofol Sedation before and after Implementation of Capnography Monitoring

Endoscopic procedures are routinely applied to cancer screening programs and surveillance. The preferred technique is usually deep sedation with propofol being a convenient agent allowing for a quicker patient recovery while maintaining a similar safety profile compared to traditional agents. However, adverse events, including respiratory depression and consequent undesirable cardiovascular side effects, may occur. The goal of this work is to evaluate the patient safety impact of adding capnography during endoscopic procedures under deep propofol sedation. Data were retrospectively collected from patients undergoing deep, procedural sedation for gastrointestinal (GI) endoscopy in October 2019 to January 2021 in a single Turkish university hospital. Included in the analysis were all adult patients classified by the American Society of Anesthesiologists (ASA) as I–IV, who were scheduled for GI endoscopy utilizing propofol alone or in combination. Data on 1840 patients were collected, of whom 1610 (730 pre- and 880 post-capnography implemention) met inclusion criteria. The primary outcome was a change in the composite incidence of mild oxygen desaturation (SpO2 75–90% for <60 s), severe oxygen desaturation (SpO2 < 75% anytime or <90% for >60 s), bradycardia (<60 ppm), and tachycardia (>25% from baseline). Without capnography, on average, 7.5 events of the primary endpoint were observed per 100 procedures and 2.9 with additional capnography monitoring (p < 0.001). A significant reduction was observed for mild oxygen desaturation, with a resulting odds ratio of 0.25 (95% CI 0.14 to 0.46). ASA I patients had the highest difference in combined incidence of any oxygen desaturation of 5.85% in the pre-capnography group and 0.64% in the post-capnography group. Although procedural sedation using propofol is not associated with severe adverse events, the incidence of composite adverse events could be reduced with the addition of capnography monitoring.
Citrus Extract High in Flavonoids Beneficially Alters Intestinal Metabolic Responses in Subjects with Features of Metabolic Syndrome

The objective of this study was to investigate the effects of a citrus extract rich in citrus flavonoids on intestinal metabolic responses in subjects with features of metabolic syndrome, in an in vitro colon fermentation system (TIM-2) and fecal samples obtained from human subjects in an in vivo trial. In the TIM-2 system inoculated with fecal samples of volunteers with features of metabolic syndrome, continuous citrus extract supplementation (500 mg/day) resulted in increased cumulative short-chain fatty acid (SCFA) levels compared to the control condition, which was mainly due to increased production of butyrate, acetate, and valerate. In human volunteers, 12 weeks of daily supplementation with 500 mg citrus extract resulted in a significant shift in the SCFA profile towards more butyrate (p = 0.022) compared to the placebo group. Furthermore, there was a trend towards a reduction in fecal calprotectin levels, a marker for intestinal inflammation, compared to the placebo (p = 0.058). Together, these results suggest that citrus extract intake may have a positive effect on intestinal metabolic responses and through this, on host health in subjects with features of metabolic syndrome. Further research is needed to provide more insight into the potential underlying mechanisms and to study effects on clinical parameters.
Using i-GONAD for Cell-Type-Specific and Systematic Analysis of Developmental Transcription Factors In Vivo

Simple Summary Gene activity is regulated by transcription factors and interacting proteins that bind to chromosomes in cells of developing embryos, adult organisms, and during disease. Thus, it is important to understand how transcription factors function in a specific biological context. By combining established approaches, this study outlines an efficient strategy to generate mouse models that facilitate the analysis of transcription factors in defined cell types. These mouse models improve existing methods for the identification of interacting proteins and chromosomal binding sites of transcription factors. Two transcription-factor-encoding genes with important functions in the developing nervous system and an association with neurodevelopmental disorders were genetically modified in mice and will serve as valuable tools for the investigation of nervous system development and related disease. Abstract Transcription factors (TFs) regulate gene expression via direct DNA binding together with cofactors and in chromatin remodeling complexes. Their function is thus regulated in a spatiotemporal and cell-type-specific manner. To analyze the functions of TFs in a cell-type-specific context, genome-wide DNA binding, as well as the identification of interacting proteins, is required. We used i-GONAD (improved genome editing via oviductal nucleic acids delivery) in mice to genetically modify TFs by adding fluorescent reporter and affinity tags that can be exploited for the imaging and enrichment of target cells as well as chromatin immunoprecipitation and pull-down assays. As proof-of-principle, we showed the functional genetic modification of the closely related developmental TFs, Bcl11a and Bcl11b, in defined cell types of newborn mice. i-GONAD is a highly efficient procedure for modifying TF-encoding genes via the integration of small insertions, such as reporter and affinity tags. The novel Bcl11a and Bcl11b mouse lines, described in this study, will be used to improve our understanding of the Bcl11 family’s function in neurodevelopment and associated disease.
Does implementation matter if comprehension is lacking? A qualitative investigation into perceptions of advance care planning in people with cancer

This article was originally published as: Ugalde, A. , O'Callaghan, C. , Byard, C. , Brean, S. , MacKay, J., Boltong, A. , Davoren, S. , Lawson, D. , Parente, P., Michael, N. , & Livingstone, P. (2018). Does implementation matter if comprehension is lacking? A qualitative investigation into perceptions of advance care planning in people with cancer. Supportive Care in Cancer, Online First. http://doi.org/10.1007/s00520-018-4241-y