Miracle-dz/UniFAR-FTUs huggingface dataset:
The Value Relevance of Revenue for Internet Firms: Does Reporting Grossed-up or Barter Revenue Make a Difference?

This study provides evidence on (a) the market's response to revenue and revenue announcements, (b) the extent of the use of grossed-up and barter revenue by Internet firms, and (c) whether the value relevance of revenue differs when Internet firms report grossed-up or barter revenue. Results indicate that revenue announcements are highly associated with three-day market returns and provide information incremental to that contained in earnings announcements. The use of grossed-up and barter revenue is common for certain sectors of Internet firms, but not pervasive across sectors. Evidence suggests that the value relevance of revenue for firms reporting grossed-up and barter revenue declined subsequent to the "crash" in April 2000. Additional analyses explore the effect of active individual investors on the pricing of revenue for firms reporting grossed-up and barter revenue. Findings suggest higher pricing of revenue for firms reporting grossed-up or barter revenue with relatively greater individual investor following.
Management of heparin-induced thrombocytopenia

Background: Heparin-induced thrombocytopenia (HIT) is a rare but severe prothrombotic adverse effect of heparin treatment. The underlying cause is the formation of highly immunogenic complexes between negatively charged heparin and positively charged platelet factor 4 (PF4). Resulting antibodies against these PF4/heparin complexes can activate platelets via the platelet FcγIIa receptor, leading to thrombin generation and thus to the paradox of a prothrombotic state despite thrombocytopenia and application of heparin. Prompt diagnosis of HIT is important in order to change treatment to prevent severe thromboembolic complications. However, this is often difficult as thrombocytopenia is frequent in hospitalized patients and the commercially available laboratory tests for HIT antibodies have a high negative predictive value but only a poor positive predictive value. This leads to overdiagnosis and overtreatment of HIT, which also bear the risk for adverse outcomes. Areas covered: This review aims at resuming recent data on HIT, thereby focusing on the role of new anticoagulants and providing a framework for diagnosis and treatment. Furthermore, it provides some insights into the pathogenesis of this peculiar adverse drug reaction and ventures a guess at its future relevance in clinical practice. Expert opinion: New drugs which are strongly negatively charged should be assessed for their capacity to form complexes with PF4. If they do so, they bear the risk of inducing a HIT-like immune response. The immunology of HIT is still largely unresolved. Understanding HIT might provide insights into other immune and autoimmune response mechanisms.
siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells

In order to estimate the effects of small interfering RNA (siRNA) targeting retinoblastoma binding protein 2 (RBP2) on the proliferation, expression, invasion, migration and tumorigenicity abilities of papillary thyroid carcinoma K1 cells, siRNA targeting RBP2 (RBP2-siRNA) and negative control siRNA were transfected into K1 cells. The mRNA levels of RBP2 in the transfected cells were estimated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and the protein levels of RBP2 in these cells were evaluated by western blot analysis and immunocytochemical (ICC) analyses. The growth, tumorigenicity, migration and invasion abilities of the transfected cells were measured by Cell Counting Kit-8 (CCK-8), soft agar colony formation and transwell chamber assay, respectively. The ICC results demonstrated that the protein expression levels of RBP2 were lower in the RBP2-siRNA-transfected cells than in the blank and control cells (analysis of variance, F=26.754, P<0.01). RBP2-siRNA downregulated RBP2 at the mRNA (t=8.869) and protein level (F=60.835) (P=0.000 vs. control cells). In addition, the transfection of RBP2-siRNA into K1 cells also suppressed cell proliferation at 24, 48 and 72 h post-transfection (t=7.650, P<0.01; t=2.606, P=0.016; and t=2.377, P=0.027, respectively). Compared with the control group, the number of invasive and migrated cells were significantly reduced in the RBP2-siRNA-transfected group (t=4.774 and t=6.366, respectively; P<0.01). Furthermore, the tumorigenic potential of the cells transfected with RBP2-siRNA was markedly reduced, as indicated by the soft agar formation assay (t=2.749, P=0.014 vs. control cells). In conclusion, the transfection of RBP2-siRNA into papillary thyroid carcinoma K1 cells suppressed the expression of RBP2 in these cells, and reduced their proliferation, invasion, migration and tumorigenic potential. Therefore, targeting RBP2 may be an efficient approach to control thyroid carcinoma.
From R&D to Innovation and Economic Growth in the EU

Over the last two decades many European governments have pursued ambitious research and development (R&D) policies with the aim of fostering innovation and economic growth in peripheral regions of Europe. The question is whether these policies are paying off. Arguments such as the need to reach a minimum threshold of research, the existence of important distance decay effects in the diffusion of technological spillovers, the presence of increasing returns to scale in R&D investments, or the unavailability of the necessary socio-economic conditions in these regions to generate innovation seem to cast doubts about the possible returns of these sort of policies. This paper addresses this question. A two-step analysis is used in order to first identify the impact of R&D investment of the private, public, and higher education sectors on innovation (measured as the number of patent applications per million population). The influence of innovation and innovation growth on economic growth is then addressed. The results indicate that R&D investment, as a whole, and higher education R&D investment in peripheral regions of the EU, in particular, are positively associated with innovation. The existence and strength of this association are, however, contingent upon region-specific socio-economic characteristics, which affect the capacity of each region to transform R&D investment into innovation and, eventually, innovation into economic growth. Copyright 2004 Gatton College of Business and Economics, University of Kentucky.
Information Exchange and Distributional Implications of Price Discrimination with Internet Marketing in Agriculture

A price discrimination model is proposed to explain why firms provide extraneous information on Internet sites selling agricultural inputs. Whether an informative site is offered depends on price discrimination potential, which depends on how much farmers reveal heterogeneity by Internet behavior. Price discrimination is greater if information benefits are negatively correlated with farm size (or other characteristics), explaining why extraneous (not product-related) information is offered on Internet sales sites. Price discrimination adversely affects some farmers but may be beneficial on average because it generates free information. Outcomes depend on whether Internet users are aware of price differentials on the basis of clickstream information.
Local stakeholders’ views about destination management: who are leading tourism development?

Purpose – The purpose of the paper is to study how the local stakeholders of three different tourism destinations consider who is responsible for the development of a tourism destination (if identifiable) and why. Design/methodology/approach – This study takes a multiple case study approach. Three different destinations are compared. A qualitative research method was chosen. The data are based on the interviews of tourism and wellbeing professionals (tourism entrepreneurs, experts and regional developers). Findings – The interview results suggest that destination leadership seems to be context-dependent. Competition, co-operation and coopetition all occur in different forms in different regions. Various kinds of co-operation are distinguishable between stakeholders of case regions, and the level of leadership among actors varies in the regions; one region is strongly managed by marketing company, while on other the co-operative store chain is apparently dominant. The roles of local educational institutes .
Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study

Abstract. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and detecting light a few centimeters away. Water vapor was easily detected in the intestines and was also observed in the lungs. The relatively thick chest walls of the infants prevented detection of the weaker oxygen signal in this study. However, results from a previous phantom study, together with scaling of the results presented here to the typical chest-wall thickness of preterm infants, suggest that oxygen also should be detectable in their lungs.
External beam radiation therapy for canine intracranial meningioma.

While patient signalment, history, and clinical signs can be highly suggestive of an intracranial tumor, cross-sectional imaging is an essential step in diagnosis. There is an increasing availability of advanced imaging modalities and treatment options in Canada for dogs with intracranial tumors. Computed tomography (CT) and magnetic resonance (MR) imaging are now available to animals in most major cities in Canada, and should be recommended when an intracranial tumor is suspected. Radiation therapy is offered at veterinary hospitals in western and in eastern Canada.
Flow cytometry peripheral blood micronucleus test in vivo: Determination of potential thresholds for aneuploidy induced by spindle poisons

Non‐DNA binding genotoxins (e.g., aneugens), unlike DNA‐binding genotoxins, are theoretically expected to show thresholded concentration‐effect response curves. This is a major issue in genetic toxicology testing because the identification of thresholds in vivo can provide a safety margin for exposure to a particular compound. In the current study we measured micronucleus induction by flow cytometry to determine the dose‐response curves for tubulin interacting agents, a specific class of aneugens. All experiments with aneugens, which include colchicine, vinblastine, vincristine, as well as the clastogen cyclophosphamide (CP) were performed in mice to avoid the splenic elimination of micronucleated reticulocytes, which has been described in rats. Flow cytometry analysis revealed a non‐linear dose‐dependent increase in micronuclei frequencies for all tested aneugens, and a linear dose response curve for the clastogen, CP. To determine whether micronucleus induction at higher doses was due to chromosome loss (aneuploidy) or chromosome breakage (clastogenicity), flow sorting of the micronucleated reticulocytes and fluorescent in situ hybridization (FISH) with a mouse pan centromeric probe were performed for vinblastine, vincristine, and colchicine. Statistical evaluation of the flow cytometry and FISH data was performed to determine the threshold levels for chromosome loss in vivo. The threshold concentrations for vinblastine, vincristine, and colchicine were found at 0.35, 0.017, and 0.49 mg kg−1, respectively. Environ. Mol. Mutagen. , 2010. © 2009 Wiley‐Liss, Inc.
Enterprise Unionism from a Korean Perspective

This study examines the structural and functional features and institutional stability of enterprise unions in the Korean manufacturing sector in the late 1980s. Both the positive relationship between the proportion of unionized firms and firm size, and the distinct function of enterprise unions are identified and explained. The dramatic rise of the labor movement since mid-1987 undermined the institutional stability of Korean enterprise unions. Finally, a broad comparison of enterprise unions between Korea and Japan helps to clarify the distinct characteristics of Korean enterprise unions. The findings of this study call for further research in order to investigate diverse forms of enterprise unionism within and across Asian nations.
Investing in Diamonds

This paper examines the risk-return characteristics of investment grade gems (white diamonds, colored diamonds and other types of gems including sapphires, rubies, and emeralds). The transactions are coming from gem auctions and span the period 1999-2012. Over our time frame, the annual nominal USD returns for white and colored diamonds amount to 8.1% and 7.4%, respectively, or 5.5% and 4.8% in real terms. For a Euro investor, the returns on white and colored diamonds are about 1.3% lower than for a USD investors but the Euro returns still beat inflation by 3.5% annually. The returns for Other Gem types (rubies, emeralds and sapphires) are more volatile and somewhat lower (4.5% annual nominal returns and 2.1% in annual real terms). Applying the hedonic regression method to the data set of auction transactions of investment grade diamonds, we are able to explain more than 95% of their price variation in white diamonds. Although the diamond returns since 1999 have been below those on gold, both white and colored diamonds have significantly outperformed the US and European stock markets, US and European real estate, US government bonds, as well as European government and corporate bonds. The reward-to-risk (Sharpe ratio) of white diamonds is very close to that of US corporate government bonds. The highest Sharpe ratio (by far) over the past 14 years was the one on gold. Still, in times of crisis investments in diamonds have shown an attractive risk-return tradeoff. In spite of a small positive correlation between the diamond and the equity markets, adding diamonds to an equity portfolio still have some diversification advantages.
The public service ethos and union mobilisation : a case study of the public library service

After thirty years of neoliberal public sector reforms involving the increased use of the private sector and the import of private sector methods, in many respects, the public sector is barely recognisable from when Mrs Thatcher was elected. This study is about one specific part of the public services – the public library service – and is analysed in the context of the wider picture of change in the public services. In particular, the focus of the thesis is the attitude of library service workers to the public service ethos (PSE), whether and how it informs their attitude to their work and its potential for use by their union in mobilisation. The thesis addresses three research questions: • Has the public service ethos survived? And if it has, what does it mean for workers? • Is there a relationship between commitment to the public service ethos and union membership and activism? • Could the union utilise the ethos in its campaigning? And, if so, how? Starting from a theoretical discussion of the origins and meaning of the PSE and a discussion of the relevance of mobilisation theory, the study highlights three key areas. First, there is an examination of whether workers in the public library service believe that a PSE exists and, if so, what it means to them. It is demonstrated through qualitative and quantitative data, including a survey of union members in the library service that it is both alive and well and a significant influence on how they view their working life. Secondly, there is an analysis of whether there is a relationship between union activism and commitment and a belief in the PSE. Connected with that is a debate about the utility of the PSE as an aid to mobilisation at the workplace. Thirdly, there is a discussion of the relevance of the PSE to unions’ wider campaigning, given their expressed aim of drawing on external power resources through alliances with service user groups. The study shows that public service workers continue to believe in a PSE, offering their union the opportunity to associate itself with it, thereby distinguishing itself from the employer and strengthening the union both within and outside the workplace.
China's labour legislation: implications for competitiveness

China's labour legislation, exemplified by a series of laws passed since 1994 and culminating in the Labour Contract Law implemented in 2008, reflects the Chinese Communist Party leadership's commitment to the creation of a ‘harmonious society’. The stated key to the achievement of such goals is the encouragement of domestic consumption vis a vis the global economic crisis. Such attempts to alter consumption structure and income distribution are integral to state employment policy. In addition, this contribution will examine a number of government initiatives, for instance, moves to promote more high-tech manufacturing as well as tertiary sectors and concomitant greater mobility, which in turn demand a better educated workforce. Thus, the main concern of this contribution is to discuss the extent to which recent labour legislation is being successfully implemented in the various categories of enterprise: state, domestic private and foreign invested international businesses. Brief case studies will be cited relating to areas subject to collective bargaining by trade unions. In summary, the contribution's main topic is the extent to which enterprise employment practices in China are being influenced by labour legislation. The central hypothesis to be explored is whether labour legislation and the enhanced role of trade unions are shifting the balance of bargaining power in favour of employees.
Identification of the E5 open reading frame of human papillomavirus type 16

Sequencing of the E5 open reading frame (ORF) of human papillomavirus type 16 revealed an additional nucleotide, a thymidine residue, at position 3903 compared with the original sequence (Seedorf et al., Virology 145:181-185, 1985). The additional T had two effects; first, in reading frame 2, in which the original E5 ORF was predicted, the additional T changed the reading frame downstream of position 3903 to create an ORF, which we designated E5, that terminated at position 4018 and potentially encoded a 52-amino-acid polypeptide. Secondly, in reading frame 3, a new ORF was created (positions 3807 to 4097), which we propose is the authentic papillomavirus type 16 E5 ORF. It contained a methionine residue and encoded an additional 82 amino acids. Both ORFs have been cloned into bacterial expression vectors (pATH), and the fusion proteins have been used to generate polyclonal antibodies in rabbits.
Novel Predictive Electric Li-Ion Battery Model Incorporating Thermal and Rate Factor Effects

This paper presents the development of the electrical aspects of a Li-ion battery model that includes charge extraction due to current, battery capacity, effect of internal resistance, and thermal effects beyond only temperature rise due to power lost. Thermal models that represent temperature rise in the core and crust of each individual cell and a rate factor function that corrects the amount of charge extracted are developed to improve the accuracy of the battery characteristics. In addition, a predictive feature has been developed for this model so that it can predict the battery output characteristics over the selected operating range of temperatures and batteries with the limited amount of input data. In the end, a nine-cell stacking model is proposed and analyzed for its effect for different cooling methods (series and parallel cooling configurations). The simulation results show that the characteristics of the proposed model compared well with the published data.
Ring a Ring O' Roses: Quality Journals and Gamesmanship in Management Studies

A paper in one of the quality journals of Management Studies is much more important as a unit of measurement than as a contribution to knowledge. It measures academic performance and determines much academic funding. There is consequently some pressure to publish in quality journals. But quality journals are defined in terms that are themselves defined in terms of quality journals - a circularity that explains both the paper's title and the frustration of those who do not mix in these circles. We examine the gamesmanship of publishing in quality journals. Findings from a survey of heads of Management Studies departments in UK universities suggest that such gamesmanship is common. Cunning and calculation now support scholarship in Management Studies. Gamesmanship will remain common until the rewards for publishing attach to the content of papers, to "what" is published rather than "where" it is published. We propose a 'Tinkerbell Solution': without belief in the value of a paper in a quality journal, the game is no longer worth playing. Copyright Blackwell Publishing Ltd 2007.
Electronic Government (E-Government) and Development

E-government denotes the strategic, co-ordinated use of information and communication technologies (ICT) in public administration and political decision-making. The benefits it is expected to deliver are greater efficiency of the institutions concerned, improvements in public services, and political participation and transparency. But fast results can only be expected where a sound institutional base and good technical and infrastructural facilities already exist. In the foreseeable future, the introduction of e-government will mainly be confined to the industrialised and more advanced developing countries. However, potential uses are also opening up for the poorer countries. In many cases, the obstacles to reform are not so much financial and infrastructural difficulties as political blockades. Development cooperation can use e-government as a means of supporting partner countries in devising and implementing political and administrative reforms and in improving market-oriented frameworks. Beyond the imm.
LUNG NODULE DETECTION USING HYBRID CLASSIFIER

convincing results and increases the speed of analysis. Since the nodules are attached to blood vessels, detection of lung nodule is a challenging task. To deal with this issue MR8 (Maximum response 8) filter bank based approach is used before preprocessing and eight maximum responses are obtained. From that response texture, intensity and gradient features are extracted using LBP (Local Binary Pattern), HOG (Histogram of Oriented Gradient), SIFT (scale invariant feature transform) descriptor respectively. Further the performances of features are analyzed by hybrid classifier. Hybrid classifier approach is to embed SVM (Support Vector Machine) with ID3 (Iterative Dichotomiser).