Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of PTSD and comorbid symptoms in adult and elderly refugees: does age matter?

2 Is there a difference in the reduction of PTSD symptoms and comorbid symptoms before and after treatment of traumatized adult and elderly refugees? To research this subject, data of ninety-one adults (aged 18 – 49) and thirty-three elderly (aged 50 – 63) were drawn from the electronic patient record of Centrum '45, a specialized center for traumatized refugees and asylum seekers. In the overall sample, small decreases in PTSD, anxiety and depression symptoms were found with an effect size of approximately 0.12. No age effects were found in treatment progression and symptom severity. Unexpectedly we found symptom severity before treatment predicted treatment progression. The present study has brought us a step forward in gaining knowledge of PTSD in elderly refugees. However, research on this subject is limited and clearly further research is required. Further research should focus on a more general PTSD population and also include elderly with a higher mean age.
On max-min fairness and scheduling in wireless ad-hoc networks: analytical framework and implementation

This paper addresses the problem of fairness in wireless ad-hoc networks. Usually, the problem of fairness in wireless ad-hoc networks is addressed in a classic approach inherited from wired networks. The common assumption is that nodes/flows have pre-assigned fair shares. The task becomes then to modify wired networks' fair queueing algorithms to address wireless network nature. Wired networks have efficient means of allocating fiar shares through admission control and additionally, the fair shares remain constant throughout the session duration due to the static nature of the nodes. In ad-hoc networks, it is meaningless to assume statically pre-assigned fair shares, since on one hand, not only the nodes move, but also the routers are mobile, and on the other hand, contention is location dependent, such that in terms of absolute guarantees, fairness would at most mean "avoiding starvation": thus applying rate proportional fiar queueing algorithms is beyond the original goal of such algorithm, viz. flow isolation/protection and bandwidth guarantee. In this work we argue in favor of multi-level scheduling for wireless ad-hoc networks with max-min fair allocation of the fair shares at the lower-most layer (MAC layer). This paper, mainly lays down the theoretical framework by which one can calculate the fair shares that would achieve max-min fairness in an ad-hoc network. We design distributed algorithms that allow each node to determine its max-min per-link fair share in a global ad-hoc network without knowledge of the global topology of the network. The results are then used in conjunction with a novel practical scheduling algorithm for IEEE 802.11 to show how fairness is achieved
Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells

ABSTRACT Hantaviruses infect endothelial cells and cause 2 vascular permeability-based diseases. Pathogenic hantaviruses enhance the permeability of endothelial cells in response to vascular endothelial growth factor (VEGF). However, the mechanism by which hantaviruses hyperpermeabilize endothelial cells has not been defined. The paracellular permeability of endothelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (VE-cadherin) within adherens junctions, which is regulated by VEGF receptor-2 (VEGFR2) responses. Here, we investigated VEGFR2 phosphorylation and the internalization of VE-cadherin within endothelial cells infected by pathogenic Andes virus (ANDV) and Hantaan virus (HTNV) and nonpathogenic Tula virus (TULV) hantaviruses. We found that VEGF addition to ANDV- and HTNV-infected endothelial cells results in the hyperphosphorylation of VEGFR2, while TULV infection failed to increase VEGFR2 phosphorylation. Concomitant with the VEGFR2 hyperphosphorylation, VE-cadherin was internalized to intracellular vesicles within ANDV- or HTNV-, but not TULV-, infected endothelial cells. Addition of angiopoietin-1 (Ang-1) or sphingosine-1-phosphate (S1P) to ANDV- or HTNV-infected cells blocked VE-cadherin internalization in response to VEGF. These findings are consistent with the ability of Ang-1 and S1P to inhibit hantavirus-induced endothelial cell permeability. Our results suggest that pathogenic hantaviruses disrupt fluid barrier properties of endothelial cell adherens junctions by enhancing VEGFR2-VE-cadherin pathway responses which increase paracellular permeability. These results provide a pathway-specific mechanism for the enhanced permeability of hantavirus-infected endothelial cells and suggest that stabilizing VE-cadherin within adherens junctions is a primary target for regulating endothelial cell permeability during pathogenic hantavirus infection.
A Low-Power WCDMA Transmitter With an Integrated Notch Filter

A filtering technique to attenuate the receive-band noise enables a 65-nm CMOS WCDMA transmitter to achieve an output noise level of -160 dBc/Hz at 80-MHz offset, while dissipating 65 mW. Using a feedback filtering technique, the circuit introduces a null with an arbitrary width at the receive frequency and eliminates the need for an external SAW filter. A stability analysis is performed to choose the most suitable architecture for the feedback path, which ensures stability over a wide range of loop-gain. Nonideal effects such as quadrature phase and gain errors, LO feedthrough, harmonic downconversion and phase-noise are also analyzed.
Dual-Polarized Dual-Band Patch Antenna Loaded With Modified Mushroom Unit Cell

In this letter, novel designs of a triple-band linearly polarized patch antenna as well as a dual-band dually polarized patch antenna are proposed. A square slot is etched out along the diagonal of a conventional patch antenna, which is further loaded with a modified mushroom unit cell to achieve a triple-band operation. The lower-order modes are combined to achieve a circularly polarized mode, thus leading to the design of a dual-band dually polarized patch antenna. Both the triple- and dual-band prototypes of a modified mushroom loaded patch are fabricated to validate the results obtained in simulation. The results obtained in both the electromagnetic (EM) simulations and measurements are in good agreement.
Manuscript Submitted to Ieee Transactions on Pattern Analysis and Machine Intelligence 1 3d-face Discriminant Analysis Using Gauss-markov Posterior Marginals

—We present a Markov Random Field model for the analysis of lattices (e.g., images or 3D meshes) in terms of the discriminative information of their vertices. The proposed method provides a measure field that estimates the probability of each vertex being " discriminative " or " non-discriminative " for a given classification task. To illustrate the applicability and generality of our framework, we use the estimated probabilities as feature scoring to define compact signatures for three different classification tasks: (i) 3D Face Recognition, (ii) 3D Facial Expression Recognition and (iii) Ethnicity-based Subject Retrieval, obtaining very competitive results. The main contribution of this work lies in the development of a novel framework for feature selection in scenaria in which the most discriminative information is smoothly distributed along a lattice.
Extending Hypermedia Conceptual Models to Support Hyperknowledge Specifications

Most of multimedia documents available today are agnostic to data semantics and their specification language offer little to ease authoring of meaningful content. In this paper, we present the main entities of the version 3.1 of the Nested Context Model (NCM), which concentrate efforts at integrating support for enriched knowledge description to the model. This extension enables the specification of relationships between knowledge descriptions and multimedia content in the hypermedia way, composing what we call hyperknowledge in this paper. NCM previous version (3.0) is a hypermedia conceptual model. NCL (Nested Context Language), which is part of international standards and ITU recommendations, was engineered according to NCM 3.0 definitions. The extensions discussed in this paper contribute not only for advances in the NCL, but mainly as a conceptual model for hyperknowledge document engineering.
Reading, Writing, and Animation in Character Learning in Chinese as a Foreign Language

Previous studies suggest that writing helps reading development inChinese in both first and second language settings by enabling higher-quality orthographic representation of the characters. This study investigated the comparative effectiveness of reading, animation, and writing in developing foreign language learners' orthographic knowledge of Chinese and found that, for learners with existing orthographic knowledge, thethreelearningconditionsfacilitatedcharacterlearningindifferentways:Writingand animation both led to better form recognition, while reading produced superior meaning and sound recalls. In addition, the effect of animation in meaning recall was also better thanwriting.Indeveloping theskillofreproducingcharacters frommemory,writingwas superior. Implications for the teaching and learning of Chinese characters are offered.
GangliosideGM1 expression during human spinal cord and neural crest development.

GangliosideGM1 represents a widespread component of the neural cell plasma membranes. Cholera toxin-B subunit binds selectively to GM1. Human spinal cords at post-conception (PC) weeks 6 to 11 were examined and early GM1 expression shown on the cell plasma membrane in the developing grey matter at PC week 6. GM1 was demonstrated also in the marginal layer (white matter); on neural crest derivative plasma membrane, i.e. dorsal root (DRG) and sympathetic ganglia; along emerging fibres from DRG and neurite terminals innervating skeletal muscle. GangliosideGM1 is highly expressed in spinal cord primary cultures and is a stringent neural cell marker. GangliosideGM1 represents an early marker of neural differentiation in both spinal cord and neural crest derivatives.
Regulation of continuous but complex expression pattern of Six1 during early sensory development

Background: In vertebrates, cranial sensory placodes give rise to neurosensory and endocrine structures, such as the olfactory epithelium, inner ear, and anterior pituitary. We report here the establishment of a transgenic mouse line that expresses Cre recombinase under the control of Six1‐21, a major placodal enhancer of the homeobox gene Six1. Results: In the new Cre‐expressing line, mSix1‐21‐NLSCre, the earliest Cre‐mediated recombination was induced at embryonic day 8.5 in the region overlapping with the otic‐epibranchial progenitor domain (OEPD), a transient, common precursor domain for the otic and epibranchial placodes. Recombination was later observed in the OEPD‐derived structures (the entire inner ear and the VIIth–Xth cranial sensory ganglia), olfactory epithelium, anterior pituitary, pharyngeal ectoderm and pouches. Other Six1‐positive structures, such as salivary/lacrimal glands and limb buds, were also positive for recombination. Moreover, comparison with another mouse line expressing Cre under the control of the sensory neuron enhancer, Six1‐8, indicated that the continuous and complex expression pattern of Six1 during sensory organ formation is pieced together by separate enhancers. Conclusions: mSix1‐21‐NLSCre has several unique characteristics to make it suitable for analysis of cell lineage and gene function in sensory placodes as well as nonplacodal Six1‐positive structures. Developmental Dynamics 247:250–261, 2018. © 2017 Wiley Periodicals, Inc.
Energy balanced clustering algorithm for routing in heterogeneous wireless sensor networks

Because of sensor nodes have limited capabilities, especially the energy reserve and processing ability, routing protocols in wireless sensor networks are a crucial challenge. These routing protocols should be simple, energy-efficient, and robust to deal with a very large number of nodes. They should also be self-configurable to node failures and changes of the network topology dynamically. The most proposed routing techniques organize the network in clusters where the sensing area is divided into many sub-areas. This paper presents a new algorithm for cluster forming in heterogenous wireless sensor networks based on thenode residual energycompared to the network one. The simulation results show thatthis algorithm allows network stability extension compared to the most known clustering algorithm.
Molecular aspects of Colorectal Carcinogenesis: A Review

Colon cancer is a common malignancy associated with significant mortality. Colon carcinogenesis generally occurs in a slow and stepwise process of accumulating mutations under the influence of genetic and environmental factors, the so-called adenomacarcinoma sequence. The cellular origin of human cancer remains controversial and the mechanisms responsible for the complexity and heterogeneity of this condition remains undefined. Despite identification of genetic mutations and aberrant signaling pathways, little clinical benefit in terms of early diagnosis or treatment of advanced disease have been attained. Many reviews have analyzed genetic mutations and molecular signaling abnormalities, but the process of carcinogenesis is incompletely understood. Adenomatous polyposis coli (APC), a tumor suppressor gene, play a central role in colorectal carcinogenesis through the wnt/β-catenin signaling pathway. Recent data suggests that peroxisome proliferator-activated receptor (PPAR) γ, a nuclear receptor, is important in cell differentiation protecting against carcinogenesis. COX-2 mRNA and protein are up-regulated in colorectal cancer, suggesting a possible role in the carcinogenic process. These three are the main known molecules involved in early colorectal carcinogenesis, although their respective interactions in this role have been poorly documented. In this review, we analyze the roles and relationships of these molecules and their interactions. We also evaluate the roles of genetic and epigenetic modifications on colorectal carcinogenesis, as well as the role of micro RNAs. Finally, we assess the impact of the gut microbiome and diet on this complex process.
From Sensorimotor Praxis and Pantomine to Symbolic Representations

What lies on the two sides of the linguistic divide is fairly clear: On one side, you have organisms buffeted about to varying degrees, depending on their degree of autonomy and plasticity, by the states of affairs in the world they live in. On the other side, you have organisms capable of describing and explaining the states of affairs in the world they live in. Language is what distinguishes one side from the other. How did we get here from there? In principle, one can tell a seamless story about how inborn, involuntary communicative signals and voluntary instrumental praxis could have been shaped gradually, through feedback from their consequences, first into analog pantomime with communicative intent, and then into arbitrary category names combined into all-powerful, truth-value-bearing propositions, freed from the iconic "shape" of their referents and able to tell all. The attendant increase in speed and scope in acquiring and sharing information can be demonstrated in simple artificial life simulations that place the old and new means into direct competition: Symbolic theft always beats sensorimotor toil, and the strategy is evolutionarily stable, as long as the bottom-level categories are grounded in sensorimotor toil.
The differential attainment of boys and girls at school: investigating the patterns and their determinants

Recent research on the differential attainment of boys and girls at school has produced findings in significant contrast to the standard account on which most previous explanations of the differences between boys and girls were based. Put simply, much previous research may have been attempting to explain differences whose nature was incompletely understood. The result, if these new findings are accepted, is that further research is now necessary to discover the potential socio-economic, classroom and individual determinants of these gender gaps. In addition, it is important before such research takes place that the nature of the actual differences between the 'performance' of boys and girls is more clearly understood. This article is intended to be a part of that advance. It details differential attainment by gender for all students in Wales over 6 years and at every level of assessment from Key Stage 1 to A level. There are few significant gender differences in mathematics and the sciences (i.e. the majority of the core subjects). For all other subjects, there are no significant gender differences at the lowest level of any assessment. Otherwise, the gap in attainment between boys and girls rises with every grade or level in an assessment, leading to the conclusion that the problem, if indeed it is a problem, is one mainly facing mid-to high-attainers. Proportionately more girls are attaining high grades and more boys are attaining middle grades than might be expected. Trends over time reveal no great change in this picture at the subject level over 6 years, but in terms of aggregate scores such as government benchmarks, the gap between boys and girls is decreasing.
Diferenciación visual de niños y adultos a partir de imágenes faciales

The Colombian children access to countless sources of information via mobile devices. However, large amount of that content is inappropriate for their psychological level and can affect their normal development. As a contribution to solve this issue, this project presents an approach to differentiate children and adults from facial images. Through the design of a Binary Decision Tree based on K-nearest neighbors classifiers, a high efficiency is achieved during both training and predicting. The facial features description by age based on Fisher s Linear Discriminant Analysis (LDA) is derived from the first collection of Colombian people faces, named Bogota Face Database.
Hormone-sensitive Lipase Deficiency in Mice Causes Diglyceride Accumulation in Adipose Tissue, Muscle, and Testis*

Hormone-sensitive lipase (HSL) is expressed predominantly in white and brown adipose tissue where it is believed to play a crucial role in the lipolysis of stored triglycerides (TG), thereby providing the body with energy substrate in the form of free fatty acids (FFA). From in vitro assays, HSL is known to hydrolyze TG, diglycerides (DG), cholesteryl esters, and retinyl esters. In the current study we have generated HSL knock-out mice and demonstrate three lines of evidence that HSL is instrumental in the catabolism of DG in vivo. First, HSL deficiency in mice causes the accumulation of DG in white adipose tissue, brown adipose tissue, skeletal muscle, cardiac muscle, and testis. Second, when tissue extracts were used in an in vitro lipase assay, a reduced FFA release and the accumulation of DG was observed in HSL knock-out mice which did not occur when tissue extracts from control mice were used. Third, in vitro lipolysis experiments with HSL-deficient fat pads demonstrated that the isoproterenol-stimulated release of FFA was decreased and DG accumulated intracellularly resulting in the essential absence of the isoproterenol-stimulated glycerol formation typically observed in control fat pads. Additionally, the absence of HSL in white adipose tissue caused a shift of the fatty acid composition of the TG moiety toward increased long chain fatty acids implying a substrate specificity of the enzymein vivo. From these in vivo results we conclude that HSL is the rate-limiting enzyme for the cellular catabolism of DG in adipose tissue and muscle.
How does globalisation interact with higher education? The continuing lack of consensus

This essay attempts to ascertain whether a particular meaning of globalisation, and view on its effects and the appropriate response to it, are becoming standardised across academia. To do so, it content‐analyses a representative sample of new scholarship, mapping the various approaches of current researchers towards globalisation. The essay shows how globalisation remains a contested concept within studies of higher education, as in many other fields. Rather than globalisation being taken to refer unambiguously to global flows, pressures or trends, its meaning continues to depend on the particular perspective adopted by contemporary researchers. The same conflict is apparent concerning the impacts which are reputed to globalisation and with regard to the appropriate response to globalisation amongst academics and higher education institutions (HEIs) more generally. Perhaps the only apparent point of consensus amongst contemporary researchers is the claim that globalisation affects HEIs, rather than HEIs themselves being implicated in the promotion of globalisation. This position underplays the often important role of HEIs in encouraging cross‐border flows and pressures, and global trends such as marketisation.
Nano-motion Dynamics are Determined by Surface-Tethered Selectin Mechanokinetics and Bond Formation

The interaction of proteins at cellular interfaces is critical for many biological processes, from intercellular signaling to cell adhesion. For example, the selectin family of adhesion receptors plays a critical role in trafficking during inflammation and immunosurveillance. Quantitative measurements of binding rates between surface-constrained proteins elicit insight into how molecular structural details and post-translational modifications contribute to function. However, nano-scale transport effects can obfuscate measurements in experimental assays. We constructed a biophysical simulation of the motion of a rigid microsphere coated with biomolecular adhesion receptors in shearing flow undergoing thermal motion. The simulation enabled in silico investigation of the effects of kinetic force dependence, molecular deformation, grouping adhesion receptors into clusters, surface-constrained bond formation, and nano-scale vertical transport on outputs that directly map to observable motions. Simulations recreated the jerky, discrete stop-and-go motions observed in P-selectin/PSGL-1 microbead assays with physiologic ligand densities. Motion statistics tied detailed simulated motion data to experimentally reported quantities. New deductions about biomolecular function for P-selectin/PSGL-1 interactions were made. Distributing adhesive forces among P-selectin/PSGL-1 molecules closely grouped in clusters was necessary to achieve bond lifetimes observed in microbead assays. Initial, capturing bond formation effectively occurred across the entire molecular contour length. However, subsequent rebinding events were enhanced by the reduced separation distance following the initial capture. The result demonstrates that vertical transport can contribute to an enhancement in the apparent bond formation rate. A detailed analysis of in silico motions prompted the proposition of wobble autocorrelation as an indicator of two-dimensional function. Insight into two-dimensional bond formation gained from flow cell assays might therefore be important to understand processes involving extended cellular interactions, such as immunological synapse formation. A biologically informative in silico system was created with minimal, high-confidence inputs. Incorporating random effects in surface separation through thermal motion enabled new deductions of the effects of surface-constrained biomolecular function. Important molecular information is embedded in the patterns and statistics of motion.