Miracle-dz/UniFAR-FTUs huggingface dataset:
Chronic psychosis associated with long-term psychotomimetic drug abuse.

THE uses and abuses of the principal psychotomimetic drugs have been of increasing interest to mental health workers for approximately the past decade. Numerous articles have dealt with the consequences of ingestion, both in and out of supervised therapeutic settings. The production of prolonged adverse effects, including extended psychotic states, has been of particular significance and concern. Acute psychoses triggered by psychotomimetic drugs frequently run a course indistinguishable from acute psychoses unrelated to drug use. Such druginduced psychotic states are characterized by a relatively well-demarcated onset of the psychosis, and tend to occur in individuals with "poor premorbid" developmental histories. In recent years we have noted increasingly that psychotic patients come to our attention where no clearly defined acute episode can be specified, but who have allegedly used large doses of psychotomimetic substances over extended periods of time. We report here four such cases, in which certain similarities were
Effects of Friction and Cutting Speed on Cutting Force

Observations are made regarding the influence of cutting speed and friction on cutting force by way of finite element modeling. Simulations are validated by comparison of cutting forces and chip morphologies for the A16061-T6. Analysis of cutting forces over a wide range of cutting conditions suggests an important role of the secondary shear zone in the decrease of cutting force as a function of speed, even well into what is considered to be the adiabatic machining regime. The proposition is supported by a decrease in chip thickness and significant increase in temperature at the tool-chip interface as the speed is increased. Temperatures in the primary shear zone rise only modestly and cannot account for the change in cutting force. Furthermore, the effect contributes to the nonlinear increase of forces with respect to feed as opposed to a plowing force by the cutting edge radius.
Animal Models in Peritoneal Dialysis Research: A Need for Consensus

The development of an adequate animal model for peritoneal research remains an object of concern. In vivo peritoneal dialysis (PD) research is hampered by the large variety of available models that make interpretation of results and comparison of studies very difficult. Species and strain of experimental animals, method of peritoneal access, study duration, measures of solute transport and ultrafiltration, and sampling for histology differ substantially among the various research groups. A collective effort to discuss the shortcomings and merits of the different experimental models may lead to a consensus on a standardized animal model of PD.
Put Into Perspective for the Practicing Clinician 1715 Clinical Usefulness , Angiographic Characteristics , and Safety Evaluation of Intracoronary Acetylcholine Provocation Testing Among 921 Consecutive White Patients With Unobstructed Coronary Arteries

Coronary spasm can cause myocardial ischemia and angina in patients with and those without obstructive coronary artery disease. However, provocation tests using intracoronary acetylcholine provocation testing (ACH test) are rarely performed in clinical routine in the United States and Europe. In this study, we assessed the clinical usefulness, angiographic characteristics, and safety of the ACH test in white patients with unobstructed coronary arteries. Our study shows that the ACH test is a safe method for the assessment of coronary vasomotor function and that patients with angina and angiographically unobstructed coronary arteries often experience coronary spasm of the epicardial and microvascular coronary vessels. If such an abnormality is diagnosed (eg, with intracoronary acetylcholine provocation testing), this not only leads to reassurance of the patient that a cause for the symptoms is found, but also enables the physician to initiate the appropriate medical therapy (eg, calcium channel blockers and nitrates aimed at reducing morbidity and mortality). Moreover, this may also have important implications on our healthcare systems, because most health care–related costs in patients with unobstructed coronary arteries are due to recurrent or ongoing angina pectoris. However, consistent definitions for coronary vasomotor disorders are needed to be able to compare the frequency of such disorders between different ethnic groups (eg, whites versus Asians). In addition, based on the favorable safety profile of the ACH test as shown in this study, we hope to encourage interventionalists to add the ACH test to their portfolio in search of functional causes for angina, especially in patients with unobstructed coronary arteries. See p 1723.
Nitrergic Pathway Is the Major Mechanism for the Effect of DA-9701 on the Rat Gastric Fundus Relaxation

Background/Aims DA-9701 significantly improved gastric accommodation by increasing the postprandial gastric volume. In this study, we investigated how DA-9701 affects the rat gastric fundus relaxation. Methods Gastric fundus muscle strips (9 longitudinal and 7 circular muscles) were obtained from rats. Electrical field stimulation (EFS) was performed at various frequencies (1, 5, 10 and 20 Hz) and train durations (1, 5, 10 and 20 seconds) to select optimal condition for experiments. Isometric force measurements were performed in response to EFS. Peak and nadir were observed during the first 1 minute after initiation of EFS in control state and after sequential addition of atropine (1 μM), DA-9701 (0.5, 5, 25 and 50 μg), N-nitro-L-arginine (L-NNA, 100 μM), MRS2500 (1 μM) and tetrodotoxin (TTX, 1 μM) to the organ bath. Results The optimal frequency and duration of EFS to evoke nerve-mediated relaxation was determined as 5 Hz for 10 seconds. Addition of L-NNA in the presence of atropine and DA-9701 (50 μg) decreased nadir by inhibiting relaxation from −0.054 ± 0.021 g to −0.022 ± 0.015 g (P = 0.026) in longitudinal muscles. However, subsequent application of MRS2500 in the presence of atropine, DA-9701 (50 μg) and L-NNA did not affect nadir. In circular muscles, subsequent addition of L-NNA and MRS2500 in the presence of atropine and DA-9701 (50 μg) did not show significant change of nadir. Conclusions Our data suggest that the effect of DA-9701 on the rat gastric fundus relaxation is mainly mediated by nitrergic rather than purinergic pathway.
The Functional and Structural Outcomes of Arthroscopic Iliopsoas Release

Background: Arthroscopic release of the iliopsoas tendon may alleviate pain associated with internal snapping hip, but previous reports of physical function, hip strength, and muscle atrophy after surgery are mixed. Hypothesis: The hips of patients who underwent arthroscopic iliopsoas release would demonstrate significantly reduced hip flexion strength and iliopsoas muscle volume when compared with their contralateral hips and the hips of patients who underwent hip arthroscopy without psoas release. Study Design: Cohort study; Level of evidence, 3. Methods: Eighteen patients who underwent hip arthroscopy with iliopsoas release for symptomatic internal snapping hip and concomitant femoroacetabular impingement (FAI) and/or chondrolabral damage (release group) and 18 patients who underwent arthroscopy for FAI and/or chondrolabral damage without iliopsoas release (control group) were evaluated at a mean of 21 months (range, 16-30 months) postoperatively. Magnetic resonance images were performed and segmented to calculate iliopsoas volume. Isometric hip flexion strength was evaluated in the supine and seated positions with a custom testing apparatus. Differences between groups and differences between the operative and nonoperative limbs within groups were compared with unpaired and paired t tests, respectively. Results: In the release group, the iliopsoas muscle of the surgical limb was significantly smaller (288 ± 98 vs 384 ± 113 cm3, P < .001) and weaker in the seated position (13 ± 4.7 vs 17 ± 5.8 kg, P < .001) than the contralateral limb. Compared with the control group, the release group demonstrated a greater percentage decrease in iliopsoas volume on magnetic resonance imaging (−25% ± 9.1% vs −0.6% ± 4.6%, P < .001) and seated hip flexion strength (−19% ± 16% vs −3.9% ± 20%, P = .018) between the operative and contralateral limbs. There were no significant differences in supine strength between limbs or groups (all P > .168). Conclusion: Arthroscopic iliopsoas release results in iliopsoas atrophy with a 25% volume loss and a 19% reduction in seated hip flexion strength.
Association Between Parapneumonic Effusion and Pericardial Effusion in a Pediatric Cohort

OBJECTIVE. Associations between pleural and pericardial effusions have been described in malignancy and autoimmune disorders. Bacterial pneumonia is the most frequent cause of parapneumonic effusion; however, knowledge of the relationship between parapneumonic effusion and the presence of pericardial fluid in children is limited. We examined this relationship. METHODS. We performed a retrospective chart review of pediatric patients who were admitted to our institution during a 6-year period with a diagnosis of either parapneumonic effusion or empyema and who had undergone an echocardiogram, a computed tomography scan of the thorax, or both. All demographic, clinical, radiographic, and laboratory data of these patients were collected, and statistical analysis was done with Student's t tests and χ2 analyses. RESULTS. We reviewed the charts of 59 children with parapneumonic effusions. Forty-eight underwent 2-dimensional echocardiography, chest computed tomography scan, or both. Of these 48 patients, 54.2% (n = 26) were found to have a concomitant pericardial effusion. The majority of patients with pericardial effusions had left-sided pleural disease. Patients with pericardial effusions had more symptomatic days before hospitalization, lower pleural fluid albumin levels, elevated serum white blood cell counts, elevated pleural fluid white blood cell and absolute neutrophil counts, and an increased incidence of surgical intervention. One patient had evidence of hemodynamic compromise that required pericardiocentesis. CONCLUSIONS. We found a high incidence of pericardial effusions in pediatric patients with parapneumonic effusions. Leukocytosis, higher pleural fluid leukocyte and neutrophil counts, and a propensity for surgical intervention suggest a prognostic relationship between pericardial effusions and more severe parapneumonic disease. The majority of these pericardial collections resolve with treatment of the underlying pleural disease.
Towards Differentiated Utilization of Attribute Mutability for Access Control in Ubiquitous Computing

The operational characteristics of ubiquitous computing environments (UbiCom) generate new access control requirements which existing classical access control models fail to support efficiently. However, the Usage Control (UCON) family of models introduces components and mechanisms that seem to be able to partially match the specific requirements imposed by UbiCom environments. In this paper, an evaluation of current access control models based on a brief study of UbiCom access control requirements is presented. Then, a new access control approach that extends UCON towards a differentiated utilization of attribute mutability for easiness of administration, better performance and lower operational cost in UbiCom environments is proposed.
Joint Estimation of DOA and TDOA of Multiple Reflections in Mobile Communications

In a multipath communication scenario, it is often relevant to estimate the directions and relative delays of each multipath signal. We present an effect algorithm for the simultaneous estimation of these parameters by re-iterative super-resolution, beamforming, and MUSIC-like searching techniques. The algorithm first separates and estimates direction of arrival (DOA) of the multipath signals. Linear constrained minimum power beamforming is used to obtain the transmitted time function of the desired signal in certain incident angle. Then, time difference of arrival (TDOA) for the incident signals are mapped into phase shifts in the frequency domain. Using the DFT of the desired signal and the received data, we can separate the phase shifts in the frequency domain due to time delay by MUSIC-like searching. At the same time, the pairing of the estimated DOA and TDOA is automatically determined. Computer simulations illustrating the performance of the proposed algorithm with the Cramer-Rao bound are included.
Anaphylactoid reaction to intravenous methylprednisolone in a patient with multiple sclerosis

Exacerbations in multiple sclerosis are treated with short courses of high dose intravenous methylprednisolone. Treatment with intravenous methylprednisolone has mainly minor side effects such as transient flushing, a brief disturbance of taste, insomnia, and mild weight gain.1 An anaphylactoid reaction after intravenous methylprednisolone treatment has been described in only one patient with multiple sclerosis.2 We report on a patient with multiple sclerosis who developed an anaphylactoid reaction on high dose intravenous methylprednisolone treatment. Additional investigations were performed to elucidate the mechanism of this reaction to intravenous methylprednisolone. A 44 year old woman was admitted to our clinic because of progressive multiple sclerosis. One year before admission she had developed paresis of the legs, and subsequently of the arms. She became incontinent for urine and faeces. On admission she also complained of numb feelings and muscle cramps in her legs. The medical history mentioned hypertension for which she used propranolol and hydrochlorothiazide. The family history was negative for multiple sclerosis. On examination there was vertical nystagmus, slight paresis of the arms, paraplegia, incoordination of the arms, and loss of sensation from a mid-thoracic level. The tendon reflexes of the legs were very brisk, …
Before/after study to determine the effectiveness of the align-right cylindrical cervical pillow in reducing chronic neck pain severity.

OBJECTIVE To determine the effectiveness (at the 0.1 level of statistical significance) of the Align-Right (roll-shaped) cervical pillow (ARCP) on neck pain severity and headache/neck pain medication use in chronic neck pain subjects. DESIGN The design was a "before/after" (i.e., a "pre/post" trial). SUBJECTS Twenty-eight subjects, 25-45 yr of age with cervical spine pain of biomechanical origin of > 2 on an 11-point ordinal pain scale. OUTCOME MEASURES The primary outcome measure was severity of morning and evening neck pain. The secondary outcome measure was daily quantity of analgesics ingested. The data were analyzed descriptively and inferentially for clinically and statistically significant pre/post intervention differences. METHODS Eligible subjects who successfully finished a 2-wk baseline data-gathering period by mailing in two properly completed diaries each received a pillow and four more diaries (to be filled in over the subsequent 4 wk). Three repeated-measures analyses of variance were performed using the Bonferroni-corrected level of statistical significance of 0.03. Ninety-five percent confidence intervals (for paired-samples mean differences) were also calculated for those pre/post differences that seemed descriptively clinically important. RESULTS The clinically and statistically significant reductions in neck/shoulder pain severity in this sample of chronic neck pain subjects suggest that the ARCP is an effective therapy for target populations with the same profile as this sample. Patient characteristics predicting suitability were not studied in this project. CONCLUSION The results suggest that the ARCP has clinically important beneficial effects on the neck pain severity of most chronic neck-pain sufferers. Further randomized clinical trial research comparing the ARCP with other commonly used cervical pillows is recommended.
Influence on Cutting Forces and Vibration in High Speed Machining Pocket Corner

High speed milling hardened mould steel (above HRC50) at pocket corner generates the cutting forces increase and vibration gets fiercely because of the sudden change of cutting direction. It will cause serious wear and possible breakage of cutting tool, and poor quality of parts. Hence, the need to select reasonable cutting parameters and adopt appropriate cutting strategies will help them to achieve their goal. In this paper, the effects cutting parameters including cutting speed, pocket corner angle, feed rate per tooth and radial depth of cut on cutting force and vibration are studied. The results show that sharper pocket corner results in the increase of cutting force and makes vibration strong. Cutting force increase with the increase of cutting speeding, feed per tooth and radial depth of cut. The optimum of cutting speed leads to the decrease of vibration. It is proposed that cutting parameters should be optimized to improve tool life and processing efficiency.
Increase of extreme events in a warming world

We develop a theoretical approach to quantify the effect of long-term trends on the expected number of extremes in generic time series, using analytical solutions and Monte Carlo simulations. We apply our method to study the effect of warming trends on heat records. We find that the number of record-breaking events increases approximately in proportion to the ratio of warming trend to short-term standard deviation. Short-term variability thus decreases the number of heat extremes, whereas a climatic warming increases it. For extremes exceeding a predefined threshold, the dependence on the warming trend is highly nonlinear. We further find that the sum of warm plus cold extremes increases with any climate change, whether warming or cooling. We estimate that climatic warming has increased the number of new global-mean temperature records expected in the last decade from 0.1 to 2.8. For July temperature in Moscow, we estimate that the local warming trend has increased the number of records expected in the past decade fivefold, which implies an approximate 80% probability that the 2010 July heat record would not have occurred without climate warming.
Expression and clinical significance of C14orf166 in esophageal squamous cell carcinoma

C14orf166, a 28 kD protein regulating RNA transcription and translation, may serve a critical role in oncogenesis. The aim of the current study was to explore the association between C14orf166 expression and esophageal squamous cell carcinoma (ESCC) and to draw attention to the association between C14orf166 and the initiation, progression and prognosis of ESCC. C14orf166 expression in ESCC and paired normal tissues was detected by immunohistochemical staining, western blotting and reverse transcription-quantitative polymerase chain reaction, and the association between C14orf166 expression and clinicopathological characters of ESCC was analyzed. Survival analysis was used to assess the prognostic significance of C14orf166 and it was observed that C14orf166 expression was higher in the ESCC tissues when compared with adjacent non-cancerous tissues at protein (P<0.001) and mRNA levels (P<0.001). There was a significant difference in T stage, lymph node metastasis and TNM stage in patients categorized according to different C14orf166 expression levels. The overexpression of C14orf166 was associated with a shorter overall survival and disease-free survival, and multivariate analysis indicated that C14orf166 was an independent prognostic indicator. The present study indicates that the expression of C14orf166 is elevated in ESCC, and is potentially a valuable prognostic predictor for ESCC.
Modification and Validation of a Semi-Automated In vitro Method for Predicting the Glycemic Index of Starchy Foods

Modification and Validation of a Semi-Automated In vitro Method for Predicting The Glycemic Index of Starchy Foods Rasem El-Fahkhri Advisors: University of Guelph, 2016 Professor Alison M. Duncan Dr. Dan Ramdath The glycemic index (GI) can assist with determining the effect of food on blood glucose levels. The Englyst method is commonly used in vitro method to predict the GI, but it does not use food as eaten. The aim of this study was to establish and validate a modified semi-automated Englyst method that better estimates the GI of foods as consumed. The method was successfully established through a simulated upper gastrointestinal digestion protocol and compared with in vivo GI values. Predicted GI (pGI) was calculated from starch digestion profiles. In vivo GI was moderately correlated with pGI (r (18)= 0.51; p < 0.05), but highly correlated (r (18)= 0.72; p < 0.05) with rapidly digestible starch (RDS). Both pGI and RDS can be used as predictors for in vivo GI. This novel finding and the modified method can be used together to effectively predict the GI of starchy foods.
Generalized spectral footprint minimization for OFDMA-based cognitive radio networks

We consider joint subchannel and power allocation for an orthogonal frequency division multiple access (OFDMA)-based cognitive radio network. We formulate the downlink resource allocation problem as a spectral-footprint (bandwidth-power product) minimization problem under interference threshold at primary users, total power and quality of service constraints. The cognitive base station solves this non-convex mixed-integer programming problem iteratively by dividing it into a subchannel allocation master problem and power allocation subproblems. The subchannel assignment problem is solved by applying a modified Hungarian algorithm while the power allocation subproblems are solved by using Lagrangian techniques. Specifically, we propose a low-complexity modified Hungarian algorithm for subchannel allocation which exploits the local information in the cost matrix. The performance of our spectral-footprint minimization technique is compared with the waterfilling power allocation.
Your Online Interests: Pwned! A Pollution Attack Against Targeted Advertising

We present a new ad fraud mechanism that enables publishers to increase their ad revenue by deceiving the ad exchange and advertisers to target higher paying ads at users visiting the publisher's site. Our attack is based on polluting users' online interest profile by issuing requests to content not explicitly requested by the user, such that it influences the ad selection process. We address several challenges involved in setting up the attack for the two most commonly used ad targeting mechanisms -- re-marketing and behavioral targeting. We validate the attack for one of the largest ad exchanges and empirically measure the monetary gains of the publisher by emulating the attack using web traces of 619 real users. Our results show that the attack is effective in biasing ads towards the desired higher-paying advertisers; the polluter can influence up to 74% and 12% of the total ad impressions for re-marketing and behavioral pollution, respectively. The attack is robust to diverse browsing patterns and online interests of users. Finally, the attack is lucrative and on average the attack can increase revenue of fraudlent publishers by as much as 33%.