Miracle-dz/UniFAR-FTUs huggingface dataset:
Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study.

CONTEXT The apolipoprotein E epsilon4 (APOE epsilon4) allele is a genetic risk factor for Alzheimer disease. Recently, depression has also become recognized as a risk factor for dementia. However, the possible effect of the APOE genotype on the association between depression and dementia is unexamined. OBJECTIVE To examine the independent and combined effects of depression and APOE epsilon4 on the risk of dementia and its subtypes. DESIGN The Honolulu-Asia Aging Study, a population-based prospective cohort study of Japanese American men. SETTINGS AND PARTICIPANTS Depressive symptoms and presence of the APOE epsilon4 allele were assessed between March 1991 and October 1993 in 1932 cognitively healthy men aged 71 to 90 years. Incident cases of dementia were diagnosed during approximately 6 years of follow-up based on neurologic assessment at 2 repeated examinations (April 1994-April 1996 and October 1997-February 1999). MAIN OUTCOME MEASURES Overall dementia, Alzheimer disease, and vascular dementia. RESULTS The interaction of depression and APOE epsilon4 was statistically significant in the analytical models. Compared with men with neither APOE epsilon4 nor depression, the risk of dementia in nondepressed men with APOE epsilon4 was not significant (hazard ratio, 1.1; 95% confidence interval [CI], 0.6-1.8); however, depressed men without APOE epsilon4 had a 1.6-fold greater risk (95% CI, 0.8-3.0), whereas depressed men with APOE epsilon4 had a 7.1-fold greater risk (95% CI, 3.0-16.7) of dementia. For subtypes, we found similar increased risks of Alzheimer disease. CONCLUSIONS The APOE epsilon4 status modifies the association between depressive symptoms and dementia in elderly men. Because individuals with depressive symptoms and the APOE epsilon4 allele had a markedly increased risk of dementia, one might be especially watchful for early signs of dementia in the older person with depression who is also positive for the APOE epsilon4 allele. Because this cohort includes only men, further investigation in women is required.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance

Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the experimental methods for the identification and quantification of metabolites, ways to evaluate coverage of metabolites, and the timing of critical clinical and nonclinical studies to generate this information. In this cross-industry review, we discuss how the increased focus on human drug metabolites and their potential contribution to safety and drug-drug interactions has influenced the approaches taken by industry for the identification and quantitation of human drug metabolites. Before the MIST guidance was issued, the method of choice for generating comprehensive metabolite profile was radio chromatography. The MIST guidance increased the focus on human drug metabolites and their potential contribution to safety and drug-drug interactions and led to changes in the practices of drug metabolism scientists. In addition, the guidance suggested that human metabolism studies should also be accelerated, which has led to more frequent determination of human metabolite profiles from multiple ascending-dose clinical studies. Generating a comprehensive and quantitative profile of human metabolites has become a more urgent task. Together with technological advances, these events have led to a general shift of focus toward earlier human metabolism studies using high-resolution mass spectrometry and to a reduction in animal radiolabel absorption/distribution/metabolism/excretion studies. The changes induced by the MIST guidance are highlighted by six case studies included herein, reflecting different stages of implementation of the MIST guidance within the pharmaceutical industry.
Video Event Recognition and Anomaly Detection by Combining Gaussian Process and Hierarchical Dirichlet Process Models

In this paper, we present an unsupervised learning framework for analyzing activities and interactions in surveillance videos. In our framework, three levels of video events are connected by Hierarchical Dirichlet Process (HDP) model: low-level visual features, simple atomic activities, and multi-agent interactions. Atomic activities are represented as distribution of low-level features, while complicated interactions are represented as distribution of atomic activities. This learning process is unsupervised. Given a training video sequence, low-level visual features are extracted based on optic flow and then clustered into different atomic activities and video clips are clustered into different interactions. The HDP model automatically decide the number of clusters, i.e. the categories of atomic activities and interactions. Based on the learned atomic activities and interactions, a training dataset is generated to train the Gaussian Process (GP) classifier. Then the trained GP models work in newly captured video to classify interactions and detect abnormal events in real time. Furthermore, the temporal dependencies between video events learned by HDP-Hidden Markov Models (HMM) are effectively integrated into GP classifier to enhance the accuracy of the classification in newly captured videos. Our framework couples the benefits of the generative model (HDP) with the discriminant model (GP). We provide detailed experiments showing that our framework enjoys favorable performance in video event classification in real-time in a crowded traffic scene.
GAPP: A Proteogenomic Software for Genome Annotation and Global Profiling of Post-translational Modifications in Prokaryotes*

Although the number of sequenced prokaryotic genomes is growing rapidly, experimentally verified annotation of prokaryotic genome remains patchy and challenging. To facilitate genome annotation efforts for prokaryotes, we developed an open source software called GAPP for genome annotation and global profiling of post-translational modifications (PTMs) in prokaryotes. With a single command, it provides a standard workflow to validate and refine predicted genetic models and discover diverse PTM events. We demonstrated the utility of GAPP using proteomic data from Helicobacter pylori, one of the major human pathogens that is responsible for many gastric diseases. Our results confirmed 84.9% of the existing predicted H. pylori proteins, identified 20 novel protein coding genes, and corrected four existing gene models with regard to translation initiation sites. In particular, GAPP revealed a large repertoire of PTMs using the same proteomic data and provided a rich resource that can be used to examine the functions of reversible modifications in this human pathogen. This software is a powerful tool for genome annotation and global discovery of PTMs and is applicable to any sequenced prokaryotic organism; we expect that it will become an integral part of ongoing genome annotation efforts for prokaryotes. GAPP is freely available at https://sourceforge.net/projects/gappproteogenomic/.
Congestion avoidance, detection and alleviation in wireless sensor networks

Congestion in wireless sensor networks (WSNs) not only causes severe information loss but also leads to excessive energy consumption. To address this problem, a novel scheme for congestion avoidance, detection and alleviation (CADA) in WSNs is proposed in this paper. By exploiting data characteristics, a small number of representative nodes are chosen from those in the event area as data sources, so that the source traffic can be suppressed proactively to avoid potential congestion. Once congestion occurs inevitably due to traffic mergence, it will be detected in a timely way by the hotspot node based on a combination of buffer occupancy and channel utilization. Congestion is then alleviated reactively by either dynamic traffic multiplexing or source rate regulation in accordance with the specific hotspot scenarios. Extensive simulation results under typical congestion scenarios are presented to illuminate the distinguished performance of the proposed scheme.
Corticocortical projections to area 1 in squirrel monkeys (Saimiri sciureus)

Cortical area 1 is a non‐primary somatosensory area in the primate anterior parietal cortex that is critical to tactile discrimination. The corticocortical projections to area 1 in squirrel monkeys were determined by placing multiple injections of anatomical tracers into separate body part representations defined by multiunit microelectrode mapping in area 1. The pattern of labeled cells in the cortex indicated that area 1 has strong intrinsic connections within each body part representation and has inputs from somatotopically matched regions of areas 3b, 3a, 2 and 5. Somatosensory areas in the lateral sulcus, including the second somatosensory area (S2), the parietal ventral area (PV), and the presumptive parietal rostral (PR) and ventral somatosensory (VS) areas, also project to area 1. Topographically organized projections to area 1 also came from the primary motor cortex (M1), the dorsal and ventral premotor areas (PMd and PMv), and the supplementary motor area (SMA). Labeled cells were also found in cingulate motor and sensory areas on the medial wall of the hemisphere. Previous studies revealed a similar pattern of projections to area 1 in Old World macaque monkeys, suggesting a pattern of cortical inputs to area 1 that is common across anthropoid primates.
Enhancement of some sex hormones concentrations by consumption of leaves extract of Viscum album (mistletoe) in rats

Objective: This present study was conducted with the aim to investigate the effect of consumption of leaves extract of mistletoe on the concentration of some serum sex hormones (follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone and prolactin) in rats. Methods: Twenty-four (24) female albino Wistar rats (210-250 g final body weight) were randomly assigned into 4 groups of 6 rats each. Group 1 (control) took normal rat chow + drinking water. Group 2, extract treated-1 (ET-1), group 3, extract treated-2 (ET-2) and group 4, extract treated-3 (ET-3) in addition received 150 mg/kg, 300 mg/kg and 450 mg/kg respectively of V. album extract p.o once daily. The feeding regimens lasted for 4 weeks. Results: The serum concentrations of FSH, LH, testosterone and prolactin in control group were 0.95±0.09 μIU/mL, 1.21±0.10 μIU/mL, 6.78±0.19 ng/mL and 1.86±0.09 ng/mL respectively. FSH levels was significantly (p<0.05) higher in ET-1 compared with control and ET-3. Serum concentrations of LH and testosterone were significantly (p<0.05) higher in ET-1 and ET-2 compared with control; LH and testosterone concentrations were in turn significantly (p<0.01) lower in ET-3 compared with ET-1 and ET-2. Prolactin decreased significantly (p<0.05) in ET-1 and ET-2 compared with control. Conclusion: Moderate and controlled doses of mistletoe extract increases serum levels of FSH, LH and testosterone but decreases prolactin concentrations, which could enhance reproductive functions in normal persons and those with loss-of reproductive function. Asian Journal of Medical Science, Volume-5(3) 2014: 87-90 http://dx.doi. org/10.3126/ajms.v5i3. 9593
Lepidium meyenii ) for treatment of menopausal symptoms : A systematic eview

Maca (Lepidium meyenii), an Andean plant of the brassica (mustard) family has been used for centuries in the Andes as an adaptogenic plant to manage anemia, infertility and female hormone balance. The aim of this review was to assess the evidence for and against the effectiveness of the maca plant as a treatment for menopausal symptoms. We searched 17 databases from their inception up to June 2011 and included all randomized clinical trials (RCTs) that compared any type of maca-based intervention to a placebo for the treatment of menopausal symptoms. All studies were assessed for methodological quality using the Cochrane ‘risk of bias’ assessment tool. Four RCTs met all inclusion criteria. These RCTs tested the effects of maca on menopausal symptoms in healthy perimenopausal, early postmenopausal, and late postmenopausal women. Using the Kupperman Menopausal Index and the Greene Climacteric ystematic review Score, all RCTs demonstrated favorable effects of maca. There have been very few rigorous trials of maca for menopausal symptoms. The results of our systematic review provide limited evidence for the effectiveness of maca as a treatment for menopausal symptoms. However, the total number of trials, the total sample size, and the average methodological quality of the primary studies, were too limited to draw firm conclusions. Furthermore, the safety has not been proved yet. Therefore, the efficacy and safety should be tested in larger studies. © 2011 Elsevier Ireland Ltd. All rights reserved.
Interaction of dietary calcium and chloride and the influence of monovalent minerals on eggshell quality.

Two experiments were conducted to determine the influence of dietary sodium and chloride on eggshell quality of leghorn hens. In the first, hens were fed for 4 wk diets containing three levels of calcium (2.0, 2.8, and 3.5%) and two levels of chloride (.25 and .86%) in a factorial arrangement of treatments involving four replicates of five hens/treatment. Neither chloride nor calcium significantly affected hen-day egg production or egg weight (P greater than .05); however, chloride decreased feed consumption and calcium increased body weight gain (P less than .05). Interactions of calcium and chloride were significant for eggshell strength (P less than .06) and eggshell thickness (P less than .05). Chloride decreased these measures of eggshell quality only for hens receiving 2.0% calcium, and calcium improved both measures only for hens receiving . 86% chloride. Chloride decreased blood bicarbonate concentration and base excess (P less than .05), but did not affect blood pH and pCO2 (P greater than .05). The effect of dietary sodium and chloride on eggshells of hens receiving 2.0% dietary calcium was determined in a second experiment. Seven diets ranging from . 18% sodium and . 94% chloride to . 76% sodium and . 24% chloride were provided for 4 wk to five replicates of five hens/treatment. Dietary sodium and chloride levels did not affect hen-day egg production or egg weight (P greater than .05). Increasing the proportions of sodium relative to chloride decreased food intake but increased eggshell strength and thickness (P less than .01) and increased blood pH (P less than .05), bicarbonate concentration (P less than .01), and base excess (P less than .01). (ABSTRACT TRUNCATED AT 250 WORDS)
Preclinical evidence for combining the 5‐HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence

Varenicline, a nicotinic acetylcholine receptor partial agonist, is used to treat nicotine dependence. Lorcaserin, a 5‐HT2C receptor agonist has been approved in some countries to treat obesity. Based on preclinical and preliminary clinical evidence, lorcaserin may have potential to treat nicotine dependence. These experiments examined in rats the effects of combining varenicline (0.5 or 1 mg/kg) and lorcaserin (0.3, 0.6 and 1 mg/kg) on nicotine self‐administration, reinstatement of nicotine seeking, responding for food and impulsive action. Both drugs alone reduced nicotine self‐administration. Combining varenicline and 0.6 mg/kg lorcaserin reduced responding to a greater extent than either drug alone. In a relapse model, extinguished nicotine seeking was reinstated by a priming injection of nicotine and nicotine‐associated cues. Reinstatement was reduced by varenicline (1 mg/kg) and by lorcaserin (0.3 mg/kg). Combining lorcaserin (0.3 mg/kg) with varenicline (0.5 or 1 mg/kg) reduced reinstatement to a greater degree than either drug alone. Both drugs had minimal effects on responding for food, alone or in combination. In the five‐choice serial reaction time test, varenicline (0.5 or 1 mg/kg) increased impulsivity, measured as increased premature responding. This effect was reduced by lorcaserin (0.3 mg/kg). Plasma levels of varenicline or lorcaserin were not altered by co‐administration of the other drug. Varenicline and lorcaserin have additive effects on nicotine self‐administration, and on nicotine seeking. Lorcaserin prevents impulsivity induced by varenicline. This pattern of effects suggests that co‐administration of varenicline and lorcaserin has potential as a treatment for nicotine dependence that may exceed the value of either drug alone.
Linear Regression for Speaker Verification

This paper presents a linear regression based back-end for speaker verification. Linear regression is a simple linear model that minimizes the mean squared estimation error between the target and its estimate with a closed form solution, where the target is defined as the ground-truth indicator vectors of utterances. We use the linear regression model to learn speaker models from a front-end, and verify the similarity of two speaker models by a cosine similarity scoring classifier. To evaluate the effectiveness of the linear regression model, we construct three speaker verification systems that use the Gaussian mixture model and identity-vector (GMM/i-vector) front-end, deep neural network and i-vector (DNN/i-vector) front-end, and deep vector (d-vector) front-end as their front-ends, respectively. Our empirical comparison results on the NIST speaker recognition evaluation data sets show that the proposed method outperforms within-class covariance normalization, linear discriminant analysis, and probabilistic linear discriminant analysis, given any of the three front-ends.
Breeding and genetics

Currently, in vivo estimation of breast meat yield is based on conformation score in the turkey industry. Ultrasound measurements of muscle depth were analyzed to determine if these objective trait measurements could be used for selection in a breeding program. Two measurements of breast depth, one taken horizontally across the chest and one parallel to the keel, were captured using an ultrasound machine. Including the muscle depth traits in a linear regression on breast meat yield increased the proportion of variation explained by 4% and 11% in the male and female lines, respectively. The heritabilities of the muscle depth traits ranged from 0.42 – 0.67. These values were higher than the heritability for conformation score in both in the male line (0.37) and female line (0.38). The ultrasound traits also showed high genetic correlations to breast meat yield, ranging from 0.50 to 0.74, indicating that selection on the depth traits would result in a correlated improvement in breast meat yield. This has the potential to improve the rate genetic gain in breast meat yield, which would increase turkey production profitability.
IgE promotes type 2 innate lymphoid cells in murine food allergy

Mast cells serve an important sentinel function at mucosal barriers and have been implicated as key early inducers of type 2 immune responses in food allergy. The generation of Th2 and IgE following food allergen ingestion is inhibited in the absence of mast cells. Group 2 innate lymphoid cells are also thought to play an important early role in nascent allergic responses.
Early skip-a-day feeding of female broiler chicks fed high-protein realimentation diets. Performance and body composition.

The effect of an early skip-a-day feeding program on performance and body composition of broiler chicks fed high-protein realimentation diets was studied. One-day-old female broiler chicks were withheld from feed for 2d (0 to 2 d of age), and at 7 d of age three pens of 15 chicks each were randomly assigned to one of five treatments. One treatment (as the control) involved ad libitum access to feed, and other four treatments were subjected to a skip-a-day regimen from 7 to 13 d of age. From 14 to 20 d of age, chicks of the five treatment groups were fed diets containing 21, 21, 25, 30, or 35% protein. Thereafter, chicks were fed a commercial finisher mash diet (18% CP and 3,160 kcal/kg ME) until 56 d of age. Restricted chicks exhibited compensatory growth during the refeeding period, but the 35% CP realimentation diet impaired this phenomenon as indicated by lower recovery index. Chicks of the skip-a-day program, regardless of dietary protein level, had less abdominal fat, as compared with chicks that ate ad libitum. In comparison with the control, less body fat and ash and greater protein contents were observed in chicks fed the 35% CP realimentation diet. Greater or less liver triglyceride content was observed in chicks fed 21% CP, or the 30 and 35% CP realimentation diet, respectively, whereas, less carcass triglyceride content was found in chicks fed 21 or 35% CP realimentation diet, as compared with the control group. (ABSTRACT TRUNCATED AT 250 WORDS)
Three‐dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles

Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three‐dimensional configurational changes of the vocal fold medial surface.
Portable bluetooth low energy system for synchronize foot pressure measurement

Human gait can be detected by plantar pressure. Previous wireless portable systems were not able to collect and analyze the plantar pressure from both feet simultaneously. In this study, the multi-connection capability of CC2650 Bluetooth low energy (BLE) chip from Texas Instruments was utilized to construct the pressure sensor insoles system. A smart phone application was implemented to receive, store and display the pressure information from both feet. This system can identify the gait cycle and pressure distribution which can be used to assist the physicians or coaches during training.
One Vote Out of Step? The Effects of Salient Roll Call Votes in the 2010 Election

We investigate the relationship between controversial roll call votes and support for Democratic incumbents in the 2010 midterm elections. Consistent with previous analyses, we find that supporters of health care reform paid a significant price at the polls. We go beyond these analyses by identifying a mechanism for this apparent effect: constituents perceived incumbents who supported health care reform as more ideologically distant (in this case, more liberal), which in turn was associated with lower support for those incumbents. Our analyses show that this perceived ideological difference mediates most of the apparent impact of support for health care reform on both individual-level vote choice and aggregate-level vote share. We conclude by simulating counterfactuals that suggest health care reform may have cost Democrats their House majority.
A Method of Object Recognition which Applicable to the Real-Time Processing Using Adaptive Factors

In a video with various environments, background modeling is important for the extraction and recognition of the moving object. The Kumar method represents queue-based background modeling, because it has a fixed period of updating the inspection of a frame, there is a limit to various systems. This paper proposes a decision-making method of the factors responding to adaptation, in accordance with the background models for the period of updating the inspection of the frame and of the factors which decide the queue size for an update inspection. The grouping of which reduces in a processing time. The proposed method can improve the existing techniques of background modeling, which is not appropriate for real-time processing. In addition, the proposed method can recognize to objects more efficiently.