Miracle-dz/UniFAR-FTUs huggingface dataset:
Now You See Me: Hide and Seek in Physical Address Space

With the growing complexity of computing systems, memory based forensic techniques are becoming instrumental in digital investigations. Digital forensic examiners can unravel what happened on a system by acquiring and inspecting in-memory data. Meanwhile, attackers have developed numerous anti-forensic mechanisms to defeat existing memory forensic techniques by manipulation of system software such as OS kernel. To counter anti-forensic techniques, some recent researches suggest that memory acquisition process can be trusted if the acquisition module has not been tampered with and all the operations are performed without relying on any untrusted software including the operating system. However, in this paper, we show that it is possible for malware to bypass the current state-of-art trusted memory acquisition module by manipulating the physical address space layout, which is shared between physical memory and I/O devices on x86 platforms. This fundamental design on x86 platform enables an attacker to build an OS agnostic anti-forensic system. Base on this finding, we propose Hidden in I/O Space (HIveS) which manipulates CPU registers to alter such physical address layout. The system uses a novel I/O Shadowing technique to lock a memory region named HIveS memory into I/O address space, so all operation requests to the HIveS memory will be redirected to the I/O bus instead of the memory controller. To access the HIveS memory, the attacker unlocks the memory by mapping it back into the memory address space. Two novel techniques, Blackbox Write and TLB Camouflage, are developed to further protect the unlocked HIveS memory against memory forensics while allowing attackers to access it. A HIveS prototype is built and tested against a set of memory acquisition tools for both Windows and Linux running on x86 platform. Lastly, we propose potential countermeasures to detect and mitigate HIveS.
Induction of idiotope suppression in the anti-azophenylarsonate response of T-depleted A/J mice

The homologous, monoclonal antiidiotope, MB, induced idiotope suppression that was remarkably stable and could be transferred by B lymphocytes. Marked depletion of T cell function, confirmed by limiting diluting analysis, did not affect the ability of MB to suppress the corresponding idiotope. Suppression induced by MB appears to result from direct interaction with idiotope-positive B cells, without the intervention of idiotope-specific T suppressor cells.
Cognitive behavioral therapy practices in the treatment of obsessive-compulsive disorder in China.

In 2014, a team of psychiatrists from Mainland China jointly published the “Guideline of Compulsive Disorders Diagnosis and Treatment” (1). Shortly thereafter, the “Guide to the Prevention and Treatment of Obsessive-Compulsive Disorder in China” was published. It recommends cognitive behavioral therapy (CBT) as the first line treatment for obsessive-compulsive disorder (OCD). Although therapists and psychiatrists have been trying to treat OCD with CBT ever since CBT was introduced in China in the 1980s, these position papers—which are consistent with recommendations in the United States and Europe (2)—drew greater attention to the need to promote access to this intervention.
Safety and immunogenicity of a novel mammalian cell-derived recombinant hepatitis B vaccine containing Pre-S1 and Pre-S2 antigens in neonates.

BACKGROUND Most of the licensed hepatitis B vaccines produced by recombinant DNA contain the S protein component of the hepatitis B virus surface antigen particle but lack two important components, Pre-S1 and Pre-S2. These components have recently been shown to play an important immunogenic role by enhancing the hepatitis B surface antibody (anti-HBs) titers, stimulating response and circumventing genetic nonresponsiveness. OBJECTIVE To assess safety, tolerability and immunogenicity in neonates of a novel recombinant HBV vaccine (Bio-Hep-B) containing the S, Pre-S1 and Pre-S2 components compared with a licensed recombinant vaccine (Engerix-B) containing the S component only. METHODS Healthy neonates were randomized to receive either Bio-Hep-B (2.5 micrograms/dose) or Engerix-B (10 micrograms/dose) at ages < 24 h, 1 month and 6 months. Blood was obtained at ages 0, 1, 7 and 12 months. Tolerability was assessed by diary cards filled by the parents for 5 successive days after immunization. Immunogenicity was assessed by determination of anti-HBs antibody. RESULTS Of 205 neonates 153 were in the Bio-Hep-B group and 52 were in the Engerix-B group. Both vaccines were well-tolerated and all infants became seroprotected (anti-HBs > 10 mIU/ml). After the first dose a significantly higher proportion of neonates seroconverted in the Bio-Hep-B group than in the Engerix-B group (83% vs. 34%; P < 0.001); this difference in seroresponse was even more pronounced for those achieving seroprotective concentrations (> 10.0 mIU/ml) after the first dose: 54% vs. 7%, respectively (P < 0.001). Geometric mean concentrations were significantly higher at all points in the Bio-Hep-B group. CONCLUSION Both vaccines were well-tolerated and immunogenic. Bio-Hep-B, despite its low dose, was significantly more immunogenic and elicited more rapid antibody response. This finding has implication for future vaccine programs in regions where maternal screening for hepatitis B virus surface antigen and administration of hepatitis B immunoglobulin are not routinely practiced at birth for infants of hepatitis B virus carrier mothers.
Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination

Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR). Methyl CpG binding domain protein 4 (MBD4) binds to MutL homologue 1 (MLH1) and controls the post-transcriptional level of several MMR proteins, including MutS homologue 2 (MSH2). We show that in WT B cells activated for CSR, MBD4 is induced and interacts with MMR proteins, thereby implying a role for MBD4 in CSR. However, CSR is in the normal range in Mbd4 deficient mice deleted for exons 2–5 despite concomitant reduction of MSH2. We show by comparison in Msh2+/− B cells that a two-fold reduction of MSH2 and MBD4 proteins is correlated with impaired CSR. It is therefore surprising that CSR occurs at normal frequencies in the Mbd4 deficient B cells where MSH2 is reduced. We find that a variant Mbd4 transcript spanning exons 1,6–8 is expressed in Mbd4 deficient B cells. This transcript can be ectopically expressed and produces a truncated MBD4 peptide. Thus, the 3′ end of the Mbd4 locus is not silent in Mbd4 deficient B cells and may contribute to CSR. Our findings highlight a complex relationship between MBD4 and MMR proteins in B cells and a potential reconsideration of their role in CSR.
Efficient training of RBF neural networks for pattern recognition

The problem of training a radial basis function (RBF) neural network for distinguishing two disjoint sets in R(n) is considered. The network parameters can be determined by minimizing an error function that measures the degree of success in the recognition of a given number of training patterns. In this paper, taking into account the specific feature of classification problems, where the goal is to obtain that the network outputs take values above or below a fixed threshold, we propose an approach alternative to the classical one that makes use of the least-squares error function. In particular, the problem is formulated in terms of a system of nonlinear inequalities, and a suitable error function, which depends only on the violated inequalities, is defined. Then, a training algorithm based on this formulation is presented. Finally, the results obtained by applying the algorithm to two test problems are compared with those derived by adopting the commonly used least-squares error function. The results show the effectiveness of the proposed approach in RBF network training for pattern recognition, mainly in terms of computational time saving.
MIMO compute-and-forward

In many network communication scenarios, a relay in the network may only need to recover and retransmit an equation of the transmitted messages. In previous work, it has been shown that if each transmitter employs the same lattice code, the interference structure of the channel can be exploited to recover an equation much more efficiently than possible with standard multiple-access strategies. Here, we generalize this compute-and-forward framework to the multiple antenna setting. Our results show that it is often beneficial to use extra antennas at the receiver to rotate the channel coefficients towards the nearest integer vector instead of separating out the transmitted signals. We also demonstrate that in contrast to classical strategies, the multiplexing gain of compute-and-forward increases if the transmitters have channel state information. Finally, we apply our scheme to the two way relay network and observe performance gains over traditional strategies.
Comparison of five methods, including the PDM Epsilometer test (E test), for antimicrobial susceptibility testing of Pseudomonas aeruginosa

The antimicrobial susceptibilities of 100 clinical isolates of Pseudomonas aeruginosa to six antipseudomonal antibiotics were tested by five methods: the National Committee for Clinical Laboratory Standards (NCCLS) methods for broth microdilution, agar dilution, and agar disk diffusion; the Vitek Automicrobic System method (Vitek Systems, Hazelwood, Mo.); and the PDM Epsilometer test (E test) (AB Biodisk, Solna, Sweden). The E test results showed excellent correlation with agar dilution results, with over 90% agreement within 1 doubling dilution between the E test and reference agar dilution MICs for all antimicrobial agents tested. The E test results also showed good correlation with the results from the reference agar disk diffusion method, with 90 to 99% complete agreement and 100% essential agreement on categories for all antibiotics tested (essential agreement is the agreement obtained when minor discrepancies are ignored). Comparison of categories with the E test and broth microdilution methods, using the broth microdilution method as the reference method, gave only 59% complete agreement for gentamicin, with 28 minor discrepancies and 13 very major discrepancies. Some discrepancies were observed between results from the E test and broth methods for gentamicin, with the broth microdilution and Vitek methods giving higher MICs than the E test and other methods using agar. The most recent NCCLS guidelines for broth dilution testing have reduced the recommended levels of cation supplementation, which may enhance future agreement between results for the aminoglycosides and P. aeruginosa on broth and on agar. We found that the E test offers a simple, labor-efficient, and accurate method for MIC determination on an agar medium.
An efficient isolated bi-directional half bridge resonant DC/DC converter

Facing the rising pressure of global environment changing rapidly, energy crisis and energy saving, the technology needs of the bi-directional DC/DC converter (BDC) which has the advantages of high efficiency, small size, good dynamic performance and low cost are increasing. This paper analyzes the advantages and disadvantages of the traditional isolated bi-directional DC/DC converters, furthermore, an isolated, high efficiency, high power density LLC resonant bi-directional DC/DC converter with symmetrical topology is proposed. Through studying the calculation method of the LLC resonant circuit parameters, a 5kW, 580V/400V BDC prototype model is designed. The corresponding equivalent circuit model is established in the Cadence Pspice environment. Simulation results verify the correctness of the bi-directional DC/DC converter with symmetric topology and the calculation method of resonant circuit component parameters and show that the BDC can realize ZVS for the power switches on the resonance side and realize ZCS for the rectifier diodes on the rectifier side in the whole load range. The converter reduces loss and electromagnetic interference (EMI) and improves efficiency.
Assistive Technology and Students with Mental Retardation: Utilization and Barriers

The Arc, a national organization on mental retardation, conducted a national survey to determine the degree to which students with mental retardation use assistive technology and to identify barriers to this outcome. Findings from the survey support earlier suggestions that students with mental retardation underutilize assistive technology. The survey found that in most cases, the number of students who could benefit from devices but did not have access to them exceeded the number who actually had devices. The discussion examined barriers to device utilization.
Security implications of cyberphysical digital microfluidic biochips

A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we highlight the security vulnerabilities of DMFBs by identifying two potential attacks on a DMFB that performs enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the calibration curve of the assay operation is maliciously modified in order to make it deviate from the nominal/golden calibration curve. We demonstrate these attacks using a digital microluidics synthesis simulator. The results show that the attacks are stealthy as they do not result in any noticeable change in the DMFB synthesis.
Gene activation by interaction of an inhibitor with a cytoplasmic signaling protein

Galactose-inducible genes (GAL genes) in yeast Saccharomyces cerevisiae are efficiently transcribed only when the sequence-specific transcription activator Gal4p is activated. Activation of Gal4p requires the interaction between the Gal4p inhibitory protein Gal80p and the galactokinase paralog, Gal3p. It has been proposed that Gal3p binds to a Gal80p-Gal4p complex in the nucleus to activate Gal4p. Here, we present evidence that the Gal3p–Gal80p interaction occurs in the cytoplasm, and concurrently, Gal80p is removed from Gal4p at the GAL gene promoter. We also show that GAL gene expression can be activated by heterologous protein–protein interaction in the cytoplasm that is independent of galactose and Gal3p function. These results indicate that galactose-triggered Gal3p-Gal80p association in the cytoplasm activates Gal4p in the nucleus.
Pedometer-Based Internet-Mediated Intervention For Adults With Chronic Low Back Pain: Randomized Controlled Trial

Background Chronic pain, especially back pain, is a prevalent condition that is associated with disability, poor health status, anxiety and depression, decreased quality of life, and increased health services use and costs. Current evidence suggests that exercise is an effective strategy for managing chronic pain. However, there are few clinical programs that use generally available tools and a relatively low-cost approach to help patients with chronic back pain initiate and maintain an exercise program. Objective The objective of the study was to determine whether a pedometer-based, Internet-mediated intervention can reduce chronic back pain-related disability. Methods A parallel group randomized controlled trial was conducted with 1:1 allocation to the intervention or usual care group. 229 veterans with nonspecific chronic back pain were recruited from one Department of Veterans Affairs (VA) health care system. Participants randomized to the intervention received an uploading pedometer and had access to a website that provided automated walking goals, feedback, motivational messages, and social support through an e-community (n=111). Usual care participants (n=118) also received the uploading pedometer but did not receive the automated feedback or have access to the website. The primary outcome was measured using the Roland Morris Disability Questionnaire (RDQ) at 6 months (secondary) and 12 months (primary) with a difference in mean scores of at least 2 considered clinically meaningful. Both a complete case and all case analysis, using linear mixed effects models, were conducted to assess differences between study groups at both time points. Results Baseline mean RDQ scores were greater than 9 in both groups. Primary outcome data were provided by approximately 90% of intervention and usual care participants at both 6 and 12 months. At 6 months, average RDQ scores were 7.2 for intervention participants compared to 9.2 for usual care, an adjusted difference of 1.6 (95% CI 0.3-2.8, P=.02) for the complete case analysis and 1.2 (95% CI -0.09 to 2.5, P=.07) for the all case analysis. A post hoc analysis of patients with baseline RDQ scores ≥4 revealed even larger adjusted differences between groups at 6 months but at 12 months the differences were no longer statistically significant. Conclusions Intervention participants, compared with those receiving usual care, reported a greater decrease in back pain-related disability in the 6 months following study enrollment. Between-group differences were especially prominent for patients reporting greater baseline levels of disability but did not persist over 12 months. Primarily, automated interventions may be an efficient way to assist patients with managing chronic back pain; additional support may be needed to ensure continuing improvements. Trial Registration ClinicalTrials.gov NCT00694018; http://clinicaltrials.gov/ct2/show/NCT00694018 (Archived by WebCite at http://www.webcitation.org/6IsG4Y90E).
An Efficient Novel Key management scheme using NchooseK algorithm for Wireless Sensor Networks

In Wireless Sensor Networks Key Management i s a very challenging phenomenon. This paper gives an illustration and demonstration of mathematical model of new key management scheme which overcomes the limitation of Pre-Shared key scheme, which is extensively used in wireless sensor networks by most of the vendors. The environment of WSN is challenged by many limitations due to which there is an urgent need to manage memory which is consumed while provisioning of the key in the wireless sensor network by using N-chooseK algorithm. We were successfullyable to build a more reliable network in terms of network connectivity . Secondly it offers a scalable solution as there is no need to keep key material of all the network in each sensor node.
A novel autonomous, bioinspired swimming robot developed by neuroscientists and bioengineers

This paper describes the development of a new biorobotic platform inspired by the lamprey. Design, fabrication and implemented control are all based on biomechanical and neuroscientific findings on this eel-like fish. The lamprey model has been extensively studied and characterized in recent years because it possesses all basic functions and control mechanisms of higher vertebrates, while at the same time having fewer neurons and simplified neural structures. The untethered robot has a flexible body driven by compliant actuators with proprioceptive feedback. It also has binocular vision for vision-based navigation. The platform has been successfully and extensively experimentally tested in aquatic environments, has high energy efficiency and is ready to be used as investigation tool for high level motor tasks.
Trends in tuberculosis and the influence of HIV infection in northern Malawi, 1988-2001.

The HIV epidemic has had a major influence on tuberculosis (TB) epidemiology in sub-Saharan Africa. Notification rates of TB in the general population of most countries have risen sharply during the last two decades and TB is the leading cause of death among HIV-infected Africans. The rate of increase in case-notification rates during the 1990s and the potential for HIV-associated disease to generate secondary epidemics of TB led to suggestions that TB control measures were insufficient and indeed that TB was out of control. In this issue however Glynn and colleagues present an increasingly familiar and somewhat different picture. Their findings are that the increased TB incidence in northern Malawi has been essentially restricted to HIV-infected individuals with TB incidence rates continuing to decline among non HIV-infected individuals. Similar findings have been reported from Cote d’Ivoire Northern Thailand and South Africa and there is even more direct evidence from Tanzania that the impact of HIV infected TB cases on transmission of Mycobacterium tuberculosis may be limited. This scenario is considerably less grave than one in which HIV-associated disease generates secondary epidemics with increasing TB transmission rates increasing the incidence of TB disease in all sectors of society. Rising TB transmission rates and increasing TB incidence rates among HIV negative individuals have however been reported from Kenya and South Africa. What are the implications of these divergent findings for African countries heavily affected by HIV and TB? (excerpt)
Stable isotopes provide revised global limits of aerobic methane emissions from plants

Recently Keppler et al. (2006) discovered a surprising new source of methane – terrestrial plants under aerobic conditions, with an estimated global production of 62–236 Tg yr −1 by an unknown mechanism. This is ~10–40% of the annual total of methane entering the modern atmosphere and ~30–100% of annual methane entering the pre-industrial (0 to 1700 AD) atmosphere. Here we test this reported global production of methane from plants against ice core records of atmospheric methane concentration (CH 4 ) and stable carbon isotope ratios (δ 13 CH 4 ) over the last 2000 years. Our top-down approach determines that global plant emissions must be much lower than proposed by Keppler et al. (2006) during the last 2000 years and are likely to lie in the range 0–46 Tg yr −1 and 0–176 Tg yr −1 during the pre-industrial and modern eras, respectively.
Fast to slow transformation of denervated and electrically stimulated rat muscle

1 Denervated fast extensor digitorum longus (EDL) muscles of adult rats were stimulated electrically for up to 4 months with a ‘slow’ pattern resembling the activity in soleus (Sol) motor units and examined with antibodies against myosin heavy chains (MHCs). 2 The normal EDL contained, on average, 45 % type IIB, 29 % type IIX, 23 % type IIA and 3 % type I fibres. All type IIB and almost all type IIX fibres disappeared during the first 3 weeks of stimulation. They were replaced by type IIA and type I fibres, whose percentages increased to about 75 and 15, respectively. Type IIA fibres remained at 75 % for nearly 2 months and were then gradually replaced by type I fibres during the next 2 months. The transformation occurred sequentially in the order IIB/IIX → IIA → I, the first step (IIB/IIX → IIA) occurring after a short delay (2 weeks) and the last step (IIA → I in originally IIB or IIX fibres) after a long delay (> 2 months). During the transformation coexpression of MHCs occurred. 3 It appears that the transformation to type I fibres occurred in pre‐existing type II fibres since no signs of fibre damage or regeneration were observed. 4 Normal EDL was also stimulated through an intact nerve with the same pattern for up to 37 days. The effects on fibre type distributions were identical to those observed in the denervated EDL. The result indicated that the Sol‐like pattern of evoked muscle activity, rather than nerve‐derived trophic influences or denervation per se, was primarily responsible for the fast to slow transformation.