Miracle-dz/UniFAR-FTUs huggingface dataset:
Vaccine protection against Staphylococcus aureus pneumonia

Staphylococcus aureus pneumonia causes significant mortality in hospitalized or healthy individuals, and recent increases in morbidity are attributed to the rapid spread of methicillin-resistant S. aureus (MRSA) strains, which are often not susceptible to antibiotic therapy. α-Hemolysin (Hla), a secreted pore-forming toxin, is an essential virulence factor of MRSA in a mouse model of S. aureus pneumonia. We show that the level of Hla expression by independent S. aureus strains directly correlates with their virulence. Active immunization with a mutant form of Hla (HlaH35L), which cannot form pores, generates antigen-specific immunoglobulin G responses and affords protection against staphylococcal pneumonia. Moreover, transfer of Hla-specific antibodies protects naive animals against S. aureus challenge and prevents the injury of human lung epithelial cells during infection. Thus, Hla vaccination or immunotherapy may prevent S. aureus pneumonia in humans.
Relative importance of sectoral and aggregate sources of price changes

This paper estimates a dynamic common factor model to assess relative importance of the aggregate and the sector-specific factors that determine changes in the prices of individual products. It also examines how aggregate price changes are affected by these factors. Two different specifications of the model are estimated: the baseline model with one aggregate factor, and a second specification with two aggregate factors. In the one-actor model, the aggregate factor contributes little to the movements of changes in prices, mostly of nondurable goods whereas it seems to have important contributions to the movements of changes in prices of commodity groups mainly used as intermediate or capital goods. In the specification with two aggregate factors, the additional factor has significant effects on changes in prices of ‘farm products’ and ‘processed foods and feeds’ only. Forecast-error variance decompositions of both aggregate and disaggregate price changes suggest that sectoral factors account for most of the variability at short horizons while the contributions of the aggregate factors increase as the time horizon lengthens. The results also show that sectoral factors are not only important for relative price changes but also have significant impact on aggregate inflation. The estimated common factors have statistically significant correlations with money growth and changes in the unemployment rate.
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs. The objective of this article is to encourage those studying ligand interactions with UDP-glucuronosyltransferases (UGTs) to adequately consider the potential consequences of in vitro UGT inhibition in humans. Spurred on by interest in developing potent and selective inhibitors for improved confidence around UGT reaction phenotyping, and the increased availability of recombinant forms of human UGTs, several recent studies have reported in vitro inhibition of UGT enzymes. In some cases, the observed potency of UGT inhibitors in vitro has been interpreted as having potential relevance in humans via pharmacokinetic drug-drug interactions. Although there are reported examples of clinically relevant drug-drug interactions for UGT substrates, exposure increases of the aglycone are rarely greater than 100% in the presence of an inhibitor relative to its absence (i.e., AUCi/AUC ≤2). This small magnitude in change is in contrast to drugs primarily cleared by cytochrome P450 enzymes, where exposures have been reported to increase as much as 35-fold on coadministration with an inhibitor (e.g., ketoconazole inhibition of CYP3A4-catalyzed terfenadine metabolism). In this article the evidence for purported clinical relevance of potent in vitro inhibition of UGT enzymes will be assessed, taking the following into account: in vitro data on the enzymology of glucuronide formation from aglycone, pharmacokinetic principles based on empirical data for inhibition of metabolism, and clinical data on the pharmacokinetic drug-drug interactions of drugs primarily cleared by glucuronidation.
14 Immune Response and Immunotherapy in Chronic Lymphocytic Leukemia

Leticia Huergo-Zapico1, Ana P. Gonzalez-Rodríguez2, Juan Contesti3, Azahara Fernández-Guizán1, Andrea Acebes Huerta1, Alejandro López-Soto1 and Segundo Gonzalez1 1Functional Biology Department, Instituto Universitario Oncologico del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, 2Hematology Department, Hospital Universitario Central de Asturias, Oviedo 3Hematology Department, Hospital Cabueñe, Gijón, Spain
[PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome].

OBJECTIVE To investigate the relationship between PPARdelta + 294T/C gene polymorphism and lipid profile, obesity and left ventricular hypertrophy (LVH) in patients with metabolic syndrome (MS). METHODS This study was conducted in 300 patients with MS and 174 patients with essential hypertension (EH) and 143 patients with type 2 diabetes mellitus (T2DM). MS was diagnosed according to 1999 WHO criteria. Fasting insulin (FINS), fasting blood glucose (FBG), plasma lipids levels were measured, LVH was examined by Doppler echocardiography. The PPARdelta + 294T/C gene polymorphism were analyzed using polymerase chain reaction and subsequently digested by BSLI restriction endonuclease. RESULTS The frequencies of the PPARdelta + 294T/C genotypes were not different among three groups. Compared with T2DM and EH, MS patients had significantly higher body mass index (BMI), plasma total cholesterol, TG and LDL-C levels (P < 0.01 or P < 0.05). LVM, LVMI and incidence rate of LVH were significantly higher in MS and EH patients than that in T2DM (P < 0.01). MS patients with CC genotype had significantly higher total cholesterol and LDL-C levels than those with TT and TC genotypes (total cholesterol in CC genotype: 6.13 +/- 1.86 mmol/L vs in TC genotype: 5.14 +/- 1.10 mmol/L, P < 0.05, and CC genotype: 6.13 +/- 1.86 mmol/L vs TT genotype: 4.99 +/- 1.42 mmol/L, P < 0.01; LDL-C in CC genotype: 3.82 +/- 1.52 mmol/L vs in TC genotype: 3.14 +/- 0.88 mmol/L, P < 0.05, and in CC genotype: 3.82 +/- 1.52 mmol/L vs in TT genotype: 2.90 +/- 0.87 mmol/L, P < 0.01). BMI and LVMI in MS patients with C allele carriers (CC + TC) were significantly higher than that of TT genotype (LVMI in CC + TC: 46 +/- 10 g/m(2.7) vs in TT: 44 +/- 10 g/m(2.7); BMI in CC + TC: 26 +/- 3 kg/m(2) vs in TT: 25 +/- 3 kg/m(2), P < 0.05). CONCLUSIONS It is indicated that PPARdelta + 294T/C gene polymorphism in subjects with MS may be involved in the occurrence of obesity and dyslipidemia. MS patients with C allele had a predominant LVH than subjects with TT genotype.
Efficient Bregman Projections onto the Permutahedron and Related Polytopes

The problem of projecting onto the permutahedron PH(c)—the convex hull of all permutations of a fixed vector c—under a uniformly separable Bregman divergence is shown to be reducible to the Isotonic Optimization problem. This allows us to employ known fast algorithms to improve on several recent results on Bregman projections onto permutahedra. In addition, we present a new algorithm MergeAndPool that have better complexity when the number of distinct entries d in the vector c is small, the simplex being one such example, with c = (1, 0, 0, . . . , 0) and d = 2. MergeAndPool runs in O(n log d) for certain popular Bregman divergence measures and requires O((n log d) log U ) to find -close solutions for general uniformly separable Bregman divergences, where U is a bound on the width of the interval containing the dual solution components. These estimates matches or improves best known bounds for all Bregman projection problems onto various permutahedra, including recent results for projection onto the simplex. The same complexity bounds apply to signed permutahedra, a class that includes the `1-ball as a special case. In summary, this work describes a fast unified approach to this wellknown class of problems.
University of Birmingham Search for CP violation in D 0-+ 0 decays with the energy test

Citation for published version (Harvard): LHCb Collaboration, Aaij, R, Adeva, B, Adinolfi, M, Affolder, A, Ajaltouni, Z, Akar, S, Albrecht, J, Alessio, F, Alexander, M, Ali, S, Alkhazov, G, Alvarez Cartelle, P, Alves, AA, Amato, S, Amerio, S, Amhis, Y, An, L, Anderlini, L, Anderson, J, Andreassen, R, Andreotti, M, Andrews, JE, Appleby, RB, Aquines Gutierrez, O, Archilli, F, Artamonov, A, Artuso, M, Aslanides, E, Auriemma, G, Baalouch, M, Bachmann, S, Back, JJ, Badalov, A, Baesso, C, Baldini, W, Barlow, RJ, Barschel, C, Barsuk, S, Barter, W, Batozskaya, V, Bifani, S, Farley, N, Griffith, P, Kenyon, IR, Lazzeroni, C, Mazurov, A, McCarthy, J, Parkinson, CJ, Pescatore, L & Watson, NK 2015, 'Search for CP violation in D 0-+0 decays with the energy test', Physics Letters B, vol. 740, pp. 158-167. https://doi.org/10.1016/j.physletb. 2014.11. 043
An Activation Program as a Stick to Job Finding

In an experimental setting some Danish unemployed workers were assigned to an activation program whereas others were not. The unemployed who were assigned to the activation program found a job more quickly. We show that the activation effect increases with the distance between the place of residence of the unemployed worker and the place where the activation took place. We also find that the quality of the post-unemployment jobs was not affected by the activation program. Both findings confirm that the activation program mainly worked because it was compulsory and the unemployed did not like it. The activation program worked as a stick to job finding.
A new LMI-based approach to relaxed quadratic stabilization of T-S fuzzy control systems

This paper proposes a new quadratic stabilization condition for T-S fuzzy control systems. The condition is represented in the form of linear matrix inequalities (LMIs) and is shown to be less conservative than some relaxed quadratic stabilization conditions published recently in the literature. A rigorous theoretic proof is given to show that the proposed condition can include previous results as special cases. In comparison with conventional conditions, the proposed condition is not only suitable for designing fuzzy state feedback controllers but also convenient for fuzzy static output feedback controller design. The latter design work is quite hard for T-S fuzzy control systems. Based on the LMI-based conditions derived, one can easily synthesize controllers for stabilizing T-S fuzzy control systems. Since only a set of LMIs is involved, the controller design is quite simple and numerically tractable.
A Study on the Demand for Green Tourism and Training Program for Rural Residents

Abstract Paradigm has been shifted from dominant social paradigm (DSP), which emphasizes on growth and development, to new environmental paradigm (NEP), which focuses on both rationality of use and obligation of preservation. Because tourism is now the world’s largest industry, the environment is taking center stage in tourism development. The purpose of the study is to provide a direction for developing effective educational programs of green tourism for the residents of farming communities. The educational programs are targeting two groups: the leaders of the communities and the residents of the communities. Developing community specific on-line contents regarding green tourism of the region and promoting them are another purpose of the research. A confirmatory factor analysis was employed to examine support for the literature review on green tourism and conducted reliability analysis of 6 factors of green tourism activities.
Subsequent Development of Diffuse Large B-cell Lymphomas and Hodgkin Lymphoma Associated With Primary Immune Disorder in a 6-year-old Female: A Case Report and Review of the Literature

Neoplastic lymphoid proliferation may arise from immune deficiency or disordered regulation of the immune system. Often the neoplasms are associated with viral agents, such as Epstein-Barr virus, human immunodeficiency virus, or human herpes virus 8. Lymphoproliferative diseases have been documented in a variety of primary immune disorders. The most commonly encountered neoplastic lesion is diffuse large B-cell lymphoma (DLBCL), although Hodgkin lymphoma (HL), Burkitt lymphoma, and peripheral T-cell lymphomas and/or leukemias have also been documented in rare instances. We report a case of a 6-year-old girl with unclassifiable primary immunodeficiency diagnosed with 2 different clones of DLBCLs and subsequently developed lymphocyte-depleted, classical HL. Both neoplasms were associated with Epstein-Barr virus. To the best of our knowledge, this is the first reported occurrence of primary immune disorder-associated lymphoproliferative disease with sequential development of DLBCLs and HL in a pediatric patient. Thorough surveillance is paramount for accurate assessment of the associated lymphoproliferative disease and in ascertaining likely transformation to, or de novo evolution of a different lymphoid neoplasm. This is also important in evaluating treatment response with appropriate therapeutic adjustments if clinically indicated.
Accuracy of Self-Reported Cancer-Screening Histories: A Meta-analysis

Background: Survey data used to study trends in cancer screening may overestimate screening utilization while potentially underestimating existing disparities in use. Methods: We did a literature review and meta-analysis of validation studies examining the accuracy of self-reported cancer-screening histories. We calculated summary random-effects estimates for sensitivity and specificity, separately for mammography, clinical breast exam (CBE), Pap smear, prostate-specific antigen testing (PSA), digital rectal exam, fecal occult blood testing, and colorectal endoscopy. Results: Sensitivity was highest for mammogram, CBE, and Pap smear (0.95, 0.94, and 0.93, respectively) and lowest for PSA and digital rectal exam histories (0.71 and 0.75). Specificity was highest for endoscopy, fecal occult blood testing, and PSA (0.90, 0.78, and 0.73, respectively) and lowest for CBE, Pap smear, and mammogram histories (0.26, 0.48, and 0.61, respectively). Sensitivity and specificity summary estimates tended to be lower in predominantly Black and Hispanic samples compared with predominantly White samples. When estimates of self-report accuracy from this meta-analysis were applied to cancer-screening prevalence estimates from the National Health Interview Survey, results suggested that prevalence estimates are artificially increased and disparities in prevalence are artificially decreased by inaccurate self-reports. Conclusions: National survey data are overestimating cancer-screening utilization for several common procedures and may be masking disparities in screening due to racial/ethnic differences in reporting accuracy. (Cancer Epidemiol Biomarkers Prev 2008;17(4):748–57)
The 29-Kilodalton Thiol-Dependent Peroxidase of Entamoeba histolytica Is a Factor Involved in Pathogenesis and Survival of the Parasite during Oxidative Stress

ABSTRACT The 29-kDa surface antigen (thiol-dependent peroxidase; Eh29) of Entamoeba histolytica exhibits peroxidative and protective antioxidant activities. During tissue invasion, the trophozoites are exposed to oxidative stress and need to deal with highly toxic reactive oxygen species (ROS). In this investigation, attempts have been made to understand the role of the 29-kDa peroxidase gene in parasite survival and pathogenesis. Inhibition of eh29 gene expression by antisense RNA technology has shown approximately 55% inhibition in eh29 expression, maximum ROS accumulation, and significantly lower viability in 29-kDa downregulated trophozoites during oxidative stress. The cytopathic and cytotoxic activities were also found to decrease effectively in the 29-kDa downregulated trophozoites. Size of liver abscesses was substantially lower in hamsters inoculated with 29-kDa downregulated trophozoites compared to the normal HM1:IMSS. These findings clearly suggest that the 29-kDa protein of E. histolytica has a role in both survival of trophozoites in the presence of ROS and pathogenesis of amoebiasis.
A Methodology for Mapping Multiple Use-Cases onto Networks on Chips

A communication-centric design approach, networks on chips (NoCs), has emerged as the design paradigm for designing a scalable communication infrastructure for future systems on chips (SoCs). As technology advances, the number of applications or use-cases integrated on a single chip increases rapidly. The different use-cases of the SoC have different communication requirements (such as different bandwidth, latency constraints) and traffic patterns. The underlying NoC architecture has to satisfy the constraints of all the use-cases. In this work, we present a methodology to map multiple use-cases onto the NoC architecture, satisfying the constraints of each use-case. We present dynamic re-configuration mechanisms that match the NoC configuration to the communication characteristics of each use-case, also accounting for use-cases that can run in parallel. The methodology is applied to several real and synthetic SoC benchmarks, which result in a large reduction in NoC area (an average of 80%) and power consumption (an average of 54%) compared to traditional design approaches
The interacting places framework: conceptualizing public display applications that promote community interaction and place awareness

The proliferation of public displays, along with ubiquitous wireless communication and sensing technology, has made it possible to create a novel public communication medium: open networked pervasive displays would allow citizens to provide their own content, appropriate close-by displays, and increase their own awareness of a display's surroundings and its local communities. We envision that such displays can create interacting places, i. e. , public spaces that promote community interaction and place awareness. In this paper we describe our Interacting Places Framework (IPF), a conceptual framework for designing applications in this novel research space that we developed based on four distinct public display studies. Our IPF focuses on 4 elements: 1) content providers, i. e. , entities that will supply content; 2) content viewers, i. e. , people who are addressed by the content; 3) communication channels that deliver the content and range from inclusive, i. e. , open-for-everyone, to exclusive, i. e. , closed-group channels; and 4) an awareness diffusion layer that describes how community awareness building happens both explicitly, i. e. , through content tailored towards a specific audience, and implicitly, by observing output for other people.
Prognostic value of health-related quality-of-life data in predicting survival in patients with anaplastic oligodendrogliomas, from a phase III EORTC brain cancer group study.

PURPOSE This is one of a few studies that have explored the value of baseline symptoms and health-related quality of life (HRQOL) in predicting survival in patients with brain cancer. PATIENTS AND METHODS Baseline HRQOL scores (from the European Organisation for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire C30 and the EORTC Brain Cancer Module) were examined in 247 patients with anaplastic oligodendrogliomas to determine the relationship with overall survival by using Cox proportional hazards regression models. Refined techniques as the bootstrap resampling procedure and the computation of C indexes and R2 coefficients were used to explore the stability of the models as well as better assess the potential benefit of using HRQOL to predict survival in clinical practice and research. RESULTS Classical analysis controlled for major clinical prognostic factors selected emotional functioning (P = .0016), communication deficit (P = .0261), future uncertainty (P = .0481), and weakness of legs (P = .0001) as statistically significant prognostic factors of survival. However, several issues question the validity of these findings and no single model was found to be preferable over all others. C indexes, which estimate the probability of a model to correctly predict which patient among a randomly chosen pair of patients will survive longer, and R2 coefficients, which measure the proportion of variability explained by the model, did not exhibit major improvement when adding selected or all HRQOL scores to clinical factors. CONCLUSION While classical techniques lead to positive results, more refined analyses suggest that baseline HRQOL scores add relatively little to clinical factors to predict survival. These results may have implications for future use of HRQOL as a prognostic factor for patients with cancer.
The field brown dwarf LP 944-20 and the Castor moving group

A reliable age estimation for the field brown dwarf LP 944-20 is accomplished through the analysis of its kinematic properties. The space velocities of this star strongly suggest its membership in the so-called Castor moving group. LP 944-20 can be sensibly assumed to have the group's age, which is estimated to be ∼320 Myr, and metal content, which is found to be roughly solar. With these new constrains and the available photometry and lithium abundance, current brown dwarf models are put to a test. Using the IR magnitudes and the lithium diagnostics, the models are able to provide a reasonable description of the brown dwarf's properties (to within a few sigma) but yield an age which is roughly 50% larger than our estimate. Possible reasons for this discrepancy are discussed.
Conformal higher spin symmetries of 4D massless supermultiplets and osp(L,2M) invariant equations in generalized (super)space

Realization of the conformal higher spin symmetry on the 4d massless field supermultiplets is given. The self-conjugated supermultiplets, including the linearized N = 4 SYM theory, are considered in some detail. Duality between non-unitary field-theoretical representations and the unitary doubleton–type representations of the 4d conformal algebra su(2,2) is formulated in terms of a Bogolyubov transform. The set of 4d massless fields of all spins is shown to form a representation of sp(8). The obtained results are extended to the generalized superspace invariant under osp(L,2M) supersymmetries. World line particle interpretation of the free higher spin theories in the osp(2N,2M) invariant (super)space is given. Compatible with unitarity free equations of motion in the osp(L,2M) invariant (super)space are formulated. A conjecture on the chain of AdSd+1/CFTd → AdSd/CFTd−1 → . dualities in the higher spin gauge theories is proposed.
Effect of Syllable Articulation on Precision and Power Grip Performance

The present study was motivated by a theory, which proposes that speech includes articulatory gestures that are connected to particular hand actions. We hypothesized that certain articulatory gestures would be more associated with the precision grip than with the power grip, and vice versa. In the study, the participants pronounced a syllable and performed simultaneously a precision or power grip that was theorized to be either congruent or incongruent with the syllable. Relatively fast precision grip responses were associated with articulatory gestures in which the tip of the tongue contacted the alveolar ridge ([te]) or the aperture of the vocal tract remained small ([hi]), as well as gestures that required lip protrusion ([pu]). In contrast, relatively fast power grip responses were associated with gestures that were produced by moving the back of the tongue against the velum ([ke]) or in which the aperture of the vocal tract remained large ([hα]). In addition to demonstrating that certain articulatory gestures are systematically connected to different grip types, the study may shed some light on discussion concerning sound symbolism and evolution of speech.