Miracle-dz/UniFAR-FTUs huggingface dataset:
Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG), have attracted attention in the progression of preeclampsia. Here, we established a unique experimental model to test the role of sFLT1 in preeclampsia using a lentiviral vector-mediated placenta-specific expression system. The model mice showed hypertension and proteinuria during pregnancy, and the symptoms regressed after parturition. Intrauterine growth restriction was also observed. We further showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor (PGF) and ameliorated the symptoms. We conclude that our experimental preeclamptic murine model phenocopies the human case, and the model identifies low-dose statins and PGF as candidates for preeclampsia treatment.
Consequences of patchy distribution of light for the growth of the clonal herb Glechoma hederacea

The hypothesis that the clonal plant Glechoma hederacea can forage for light in environments with spatially patchy light supply was tested experimentally using artificial habitats in the glasshouse. There were five light treatments. Two treatments were homogeneous, with uniformly low or high light. Three treatments were patchy, each consisting of one high light patch and one low light patch. In the patchy treatments the position of the light patches differed with respect to the position at which the clone commenced growth. Several morphological responses were predicted if foraging for light through morphological plasticity took place : (I) there should be a greater concentration of ramets and biomass, a greater frequency of branching, greater leaf area, a lower proportional allocation of biomass to stolons and a higher proportional allocation of biomass to leaves in high light than in low light patches ; (2) there should be increased petiole lengths and a higher proportional allocation of biomass to stolons and petioles in low light patches than in high light patches ; (3) different primary stolons should assume different morphologies when exposed, simultaneously, to different light regimes. Structures directly involved in light acquisition in G. hederacea showed the greatest responses to changes in light conditions. In the patchy light treatments the frequency of branching, the leaf area of primary ramets and the proportional allocation to leaf biomass were significantly greater in high light patches and petiole length and proportional allocation to petiole biomass were significantly greater in low light patches. The greater leaf area, coupled with greater branching, allowed clones to harvest light energy more efficiently in high light conditions and the increase in petiole length allowed clones to escape from poor light conditions. However, these foraging responses were shown only when clones grew from low light to high light patches or when different primary stolons were exposed simultaneously to either high or low light. Foraging responses were suppressed when clones grew from high light to low light patches. These results imply that responses to patchy light conditions are not clone-wide, but localised within individual stolons, and that individual stolons can adjust morphology rapidly only when high resource patches are encountered after low resource patches. The converse - adjustment to a low resource patch following a period in a high resource patch - does not occur or occurs slowly, due to physiological integration within stolons and the predominantly acropetal nature of resource translocation.
Characterization of HIV trafficking and DC-SIGN-mediated cytoskeleton rearrangement en the context of HIV transfer across dentritic cells-T lymphocytes infectious synapses

La transmission de l’infection par le VIH s’effectue principalement par voie sexuelle et la comprehension des mecanismes lies a ce transfert au niveau des muqueuses est un sujet de recherche primordial afin de developper des outils therapeutiques a meme de prevenir la propagation du VIH. Un role majeur des cellules dendritiques muqueuses dans la transmission du VIH aux lymphocytes T a deja ete propose precedemment. Ce travail de these a permis de caracteriser les mecanismes de transfert de l’infection VIH des cellules dendritiques aux lymphocytes T via les synapses infectieuses. Les elements presentes dans cette these apportent des arguments essentiels dans la comprehension des evenements impliques au niveau de la synapse infectieuse. Nous demontrons ici le role de l’activation de la GTPase Cdc42 et des filopodes dans la transmission du VIH aux lymphocytes T. Nous proposons egalement que l’activation de la GTPase Cdc42 survient suite a la liaison de l’enveloppe du VIH a DC-SIGN et via les kinases SRC. Nos resultats objectivent egalement que differentes methodes prevenant la formation de filopodes sur les cellules dendritiques reduisent de facon importante le transfert du VIH aux lymphocytes T. Ces decouvertes ouvrent le champ vers de nouvelles approches therapeutiques dans la prevention de la transmission du VIH.
Isolation of Gene(s) Encoding Polar Flagella Core Antigen of Vibrio Parahaemolyticus

A genomic library of V. parahaemolyticus was constructed in order to isolate the gene encoding polar flagellar core antigen. DNA fragments were cloned into Lambda ZAPII vector at the EcoRI cloning site and the recombinant DNA was transformed into Escherichia coli XL1-Blue strain. Recombinant plaques were screened with rabbit polyclonal antiserum produced against polar flagella and with monoclonal antibody produced against polar flagellar core protein. The pBluescript phagemid which contained the DNA fragrnent encoding the flagellar gene was rescued and analyzed. Additional investigation was carried out by mini-Mu transposon mutagenesis to map the coding region. The flagellar core coding region was mapped within l.l kb which encompasses the NcoI site present in the 6.5 kb insert.
Complete mitochondrial genome of the endangered flower chafer Osmoderma opicum (Coleoptera: Scarabaeidae)

Abstract The flower chafer Osmoderma opicum (Coleoptera: Scarabaeidae) has been listed in Korea as a class II endangered wild species. The 15 341-bp complete mitochondrial genome (mitogenome) of the species consists of a typical set of genes (13 protein-coding genes [PCGs], two rRNA genes and 22 tRNA genes) and the A + T-rich region, with an arrangement typical of insects. The 761-bp long A + T-rich region of O. opicum has a microsatellite-like sequence consisting of (TA)6, along with a poly-T (12 bp) and a poly-A (16 bp) stretch, but does not have a longer repeat sequence often found in other Scarabaeidae. Twelve PCGs started with the typical ATN codon, whereas the COI started with AAC, which has been designated as the start codon for the coleopteran suborder Polyphaga. Phylogenetic analysis using 11 PCGs from Scarabaeidae showed that O. opicum was placed as the sister to the within-subfamilial species Myodermum sp. , forming the monophyletic group, the subfamily Cetoniinae, with moderate to high nodal support.
Design of low-order observers for linear feedback control laws

This paper considers the problem of designing an observer to estimate a linear function of the state of a linear system, for the purpose of implementing a feedback control law. In the single-output case a necessary and sufficient condition is found for the existence of an observer of given order and pole configuration. A procedure is stated for constructing the observer, and an algorithm for determining minimal order is outlined. The multi-output case is reduced via a canonical form to an output-coupled set of single-output systems which can be treated as above. Observers derived using these procedures are generally of lower order than those of Luenberger, and the restriction that plant and observer have no common poles is unnecessary.
Population density and community size structure: Comparison of aquatic and terrestrial systems

The size structure of aquatic communities is generally measured using size spectra, an approach which is tedious or inapplicable in benthic and terrestrial communities. This has inhibited comparison of size structure of aquatic and terrestrial communities. This study uses an approach more common among terrestrial ecologists to develop a general density-body size relationship for lacustrine communities, based on mean annual population densities for dominant species of phytoplankton, zooplankton, zoobenthos and fish measured in 18 lakes worldwide. Overall, mean annual population density (D, individuals m -2 ) decreases log-linearly with increasing species body size (M, μg fresh mass) as D = 4 x 10 5 . M -0.89 (n = 280, r 2 = 0.92), although the exponent appeared smaller (-0.55 ± 0.04) within broad taxonomic groups (algae, invertebrates). We found that density-body size relationships for dominant species are quantitatively similar to size spectra, a pattern which suggests that density-body size relationships may provide an interesting alternative to size spectra for the prediction of ecosystem processes. These relationships also suggest that aquatic species reach, on average, 6-60 times higher densities than terrestrial species, depending on their body size and on their thermoregulatory system (ectotherms vs endotherms). The implications of these differences in size structure for size-related patterns of energy use and other processes depend on which physiological groups (unicells, ectotherms, endotherms) are being compared.
Sur le problème de Cauchy pour les équations de la relativité générale dans les schémas matériels fluide parfait et matière pure

© Gauthier-Villars, 1968, tous droits réservés. L’accès aux archives de la revue « Annales de l’I. H. P., section A » implique l’accord avec les conditions générales d’utilisation (http://www.numdam. org/conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
Urine neutrophil gelatinase-associated lipocalin concentration in healthy newborns during the first three postnatal days

Introduction Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a biochemical marker significant for early prediction of acute kidney injury in adults. However, it has not been examined sufficiently among the infant population, particularly newborns in terms of reference values. The aim of our study was to determine the concentration of uNGAL in healthy term newborns and to determine if there was a difference in uNGAL concentration according to gender, postnatal age and birth weight. Materials and methods Our study involved 81 healthy term newborns birth (≥ 37 weeks, Apgar score ≥ 8 in the first minute after birth, CRP < 5 mg/L). Urine NGAL was measured using chemiluminescent microparticle immunoassay (CMIA) within 72 hours after birth, on Architect plus ci8200 analyser (Abbott, Chicago, USA). Data were analysed using Statistica software. Results The median concentration of uNGAL in the whole study group of healthy term newborns was 27.1 ng/mL (16.5-56.0 ng/mL) (newborn girls, 27.1 ng/mL (15.8-47.9 ng/mL); newborn boys, 27.9 ng/mL (16.5-61.0 ng/mL), P = 0.941). Median uNGAL concentration according to postnatal age expressed in days was 28.2 ng/mL (11.7-57.2 ng/mL) 1st day, 28.9 ng/mL (16.5-64.2 ng/mL) 2nd day and 23.9 ng/mL (20.2-46.6) 3rd day, P = 0.863. Regarding birth weight for newborns < 3500 g, median concentration was 25.0 ng/mL (16.5-45.4 ng/mL) and for weight ≥ 3500 g 30.6 ng/mL (16.5-64.2 ng/mL), P = 0.455. Conclusions There were no significant difference in uNGAL concentration in relation to gender, postnatal age and birth weight.
Teamwork in hip preservation: the ISHA 2019 Annual Scientific Meeting

Abstract Hip preservation surgery is now an established part of orthopedic surgery and sports medicine. This report describes the key findings of the 11th Annual Scientific Meeting of International Society for Hip Arthroscopy—the International Hip Preservation Society—in Madrid, Spain from 16 to 19 October 2019. Lectures, seminars and debates explored the most up-to-date and expert views on a wide variety of subjects, including: diagnostic problems in groin pain, buttock pain and low back pain; surgical techniques in acetabular dysplasia, hip instability, femoroacetabular impingement syndrome, labral repair and reconstruction, cartilage defects, adolescent hips and gluteus medius and hamstring tears; and new ideas about femoral torsion, hip–spine syndrome, hip capsule surgery, impact of particular sports on hip injuries, registries, robotics and training for hip preservation specialists. Surgeons, sports physicians, radiologists and physiotherapists looking after young people with hip problems have an increasingly sophisticated armoury of ideas and techniques with which to help their patients. The concept of hip preservation has developed incredibly fast over the last decade; now it is clear that the best results can only be achieved by a multidisciplinary team working together. The 2020s will be the decade of ‘Teamwork in Hip Preservation’.
Child HIV Exposure and CMV Seroprevalence in Botswana: No Associations With 24-Month Growth and Neurodevelopment

Abstract Background We sought to identify predictors of child cytomegalovirus (CMV) infection overall and by maternal HIV status and to assess associations of child CMV status with growth and neurodevelopmental outcomes at 24 months of age in Botswana. Methods Data and samples were used from the Botswana-based observational Tshipidi study (2010–2014), enrolling pregnant women living with and without HIV and following their infants through 2 years of age. Child plasma samples were tested at 18 months of age for anti-CMV immunoglobulin G (IgG). Associations were assessed between detectable anti-CMV IgG and growth (using the World Health Organization Child Growth Standards) and neurodevelopment (using the Bayley Scales of Infant and Toddler Development III and the Developmental Milestones Checklist) at 24 months of age. Results Of 317 children, 215 (68%) had detectable anti-CMV IgG at 18 months of age. Comparatively, 83% (n = 178) of HIV-unexposed uninfected (HUU) children had positive CMV serology vs 47% (n = 139) of HIV-exposed uninfected (HEU) children (P < .01); 100% of HUU vs 10.5% of HEU children breastfed. Child CMV infection was not associated with weight-for-age, weight-for-length, or length-for-age z-scores at 24 months. In HUU children, CMV infection was associated with smaller head circumference (P < .01). No difference was observed by child CMV status in any neurodevelopmental domain at 24 months. Conclusions We observed high CMV seropositivity in 18-month-old children in Botswana, with higher seropositivity among breastfed (HUU) children. Positive CMV serostatus was not associated with 24-month child growth or neurodevelopmental outcomes, with the exception of smaller head circumference among HUU CMV-positive children.
Apparent horizontal diffusion in stratified vertical shear flow

An investigation of the horizontal turbulent diffusion in relation to environmental conditions, such as density stratification, vertical current shear, and current variability, is presented. Tracer experiments have been conducted in fjords, in coastal areas, and in offshore waters with a view to obtaining data for such a study. In addition, observations of wind velocity, salinity, temperature, and current have been carried out. A model is proposed assuming that the apparent horizontal diffusion is determined by the combined action of vertical diffusion and vertical current shear. The theoretical predictions are found to compare well with the experimental results. DOI: 10.1111/j.2153-3490.1972. tb01529.x
Morphological methods for evaluation of pulmonary toxicity in animals.

Copyright 1976. All rights reserved MORPHOLOGICAL METHODS «-6655 FOR EVALUATION OF PULMONARY TOXICITY IN ANIMALS D. L. Dungworth, L. W Schwartz, W. 5’. Tyler California Primate Research Center and School of Veterinary Medicine, University of California, Davis, California 95616 R. F. Phalen Department of Community and Environmental Medicine, California College of Medicine, University of California. Irvine, California 92664 INTRODUCTION The mammalian respiratory system has a variety of important functions in addition to the primary one of gaseous exchange (1, 2). The corresponding diversity of structural components of the respiratory tract, compounded by the inhomogeneity of morphologic responses of the lung to damaging agents, necessitates extremely careful selection and implementation of the several morphological methods required for its examination. Methods must be sensitive enough to reveal the presence and nature of subtle effects, and also to provide information on which useful hypotheses of pathogenesis can be based. This review is designed to present the important considerations in the choice of methods and is a guide to references describing them in more detail. It is not intended to be a detailed critique of methods or a complete laboratory protocol. Much of the review deals with the routine necessary for the satisfactory search for and documentation of toxic eﬂ'ects. Emphasis is on the sine qua non for detecting subtle etfects, which provide the most discriminating information relevant to pulmo- nary toxicity. The remainder of the review brieﬂy addresses special methods for investigating various aspects of the pathogenesis of pulmonary lesions likely to be encountered and which are necessary for furthering the understanding of pulmonary pathobiology. ROUTINE EVALUATION Gross Examination The methods to be described in this and subsequent sections are postmortem proce- dures, although most are applicable to surgical specimens. Radiographic studies, 381
Photoinization cross sections for atomic chlorine using an open-shell random-phase approximation

The use of the Random Phase Approximation with Exchange (RPAE) for calculating partial and total photoionization cross sections and photoelectron angular distributions for open shell atoms is examined for atomic chlorine. Whereas the RPAE corrections in argon (Z=18) are large, it is found that those in chlorine (Z=17) are much smaller due to geometric factors. Hartree-Fock calculations with and without core relaxation are also presented. Sizable deviations from the close coupling results of Conneely are also found.
Notes on the Biology and Release of Caloptilia sp. nr. schinella (Walsingham) (Lepidoptera: Gracilariidae), a Biological Control Moth for the Control of the Weed Firetree (Myrica faya Aiton) in Hawaii

th Avenue, Bozeman, MT 59717-2780 Abstract. In Hawaii, the weed Myrica faya Aiton has invaded many native ecosys- tems where it is rapidly replacing many native plant species. The moth Caloptilia sp. nr. schinella is a native of the Azores and Madeira Islands in the eastern Atlantic where its natural host is M. faya. This insect was released in Hawaii in 1991 as a potential biological control agent. Eggs are laid singly on the underside of young leaves and hatch in 7 days. The first instar larvae enter the leaf where they mine under the epider- mis of the lower surface. The mines eventually coalesce into a blotch. Later instar larvae exit the blotches and externally roll the apical tip of the leaf into a cylinder that forms a distinctive feeding shelter. The last instar larvae leave their shelters and spin oval-shaped, flat cocoons in which they pupate. Development from egg to adult re- quired approximately 2 months. Extensive feeding studies conducted in quarantine in Hawaii to determine this insect's host range indicated that it can complete its develop- ment on only one additional plant, the very closely related M. cerifera L. The host test results were used in a petition submitted to the Hawaii Department of Agriculture requesting permission to release this moth as a biological control agent in Hawaii. The permit was granted in 1991. Between July 19 and October 29, 1991, 725 adults and/or pupae were released within the Volcanoes Golf Course subdivision located adjacent to the Hawaii Volcanoes National Park on the island of Hawaii. Post-release monitoring conducted in October 1992 indicated that establishment had occurred. By July 1994, the population had spread throughout the golf course subdivision and up to 5 km south- ward into Hawaii Volcanoes National Park.
Computers in Biology Providing resources for researchers on the World Wide Web—Some perspectives

U se of the World Wide Web has grown to the point at which the Internet strains under its own popularity. Nevertheless, it is an increasingly valuable research tool for biologists (Smith 1993, Robison 1997). Powerful Web search engines allow users to locate material on virtually any topic, from pertinent literature to the whereabouts of colleagues. The Web offers an effective tool for project documentation and education, and the simplicity of making resources available via the Web encourages free exchange of data for peer review, collaboration, or public dissemination (e.g., Mars Pathfinder mission information, data, and images). Researchers and educators who create and use biological Web sites are often the same scientists who write and read scholarly articles in printed publications; however, these two outlets differ beyond their media. Web pages (other than e-journals; Walker 1996) do not undergo formal review, they often have a larger readership than printed publications (see below), and they are indexed word-for-word for a worldwide audience. Nevertheless, Web pages are seldom prepared with the same scrutiny given printed publications. Authors of professional articles know that through peer and editorial review, their material will be subject to close examination and "gatekeeping" by colleagues. Web pages do not have to survive this process; they are easily published, appear in a medium lacking built-in prestige, and usually receive little critical review, even when user feedback is solicited. Morever, Web sites are seldom, if ever, entirely finished. All of these factors make it especially
Organic Semiconducting Polymers

The invention relates to novel organic semiconducting polymers containing one or more monomers derived from s-indacene fused symmetrically on each terminus with dithieno[3,2-b;2\3'-d]thiophene (IDDTT), cyclopenta[2,1-b;3,4-b']dithiophene (IDCDT), or derivatives thereof, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these polymers, polymer blends, mixtures or formulations.