Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting Health-Related Quality of Life in Trauma-Exposed Male Veterans in Late Midlife: A 20 Year Longitudinal Study

Trauma-exposed adults with high levels of posttraumatic stress symptoms (PTSS) report poorer health-related quality of life (HRQOL), but less is known about the persistence of this relationship over time. Participants from the Vietnam Era Twin Study of Aging reported on PTSS, health, and sociodemographic characteristics at average age 38; 775 participants reported having been exposed to trauma. Later, at average ages 56 and 62, mental and physical HRQOL were assessed with the Short-Form 36. Premorbid risk for anxiety/neuroticism was evaluated with a polygenic risk score derived from a large genome-wide association study meta-analysis. In multivariate mixed models, having higher levels of PTSS, poorer self-rated health, lower income, and less education at age 38 were associated with worse physical and mental HRQOL two decades later. Chronic health problems at age 38 predicted midlife physical but not mental HRQOL. Although genetic risk for neuroticism was correlated with HRQOL and PTSS, it was no longer significant in multivariate models. Health-related quality of life (HRQOL) predicts morbidity and mortality independently of objective health measures; early interventions may help to mitigate the ongoing impact of trauma on quality of life.
Estimating numerosity of visual concepts with a single spiking neuron

It has been shown that insects exhibit behaviour of basic numerical cognition such as counting. How insects develop these abilities is not yet known. Here we show that numerosity estimation can be realized and learned by a single spiking neuron with an appropriate plasticity rule. We introduce a modified synapse-based learning algorithm implemented in an integrate and fire neuron model. We demonstrate that this brain-inspired algorithm performs on par with state-of the art machine learning approaches and requires considerably less training epochs. In addition to numerosity estimation, we also show that our model is able to efficiently categorize realistic sensory input patterns on a noisy background with high precision. We propose that using action potentials to represent numerosity and other concepts within a single spiking neuron is beneficial for organisms with small brains and limited neuronal resources.
Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Limonia elephantum leaves

Limonia elephantum (wood apple) has been widely used in an Indian folk medicine system. In the present study, the acute toxicity studies were carried out to determine the safety of the compounds in liver diseases. The antioxidant and the hepatoprotective properties of the L. elephantum are evaluated against paracetamol induced hepatic damage in rats. Liver superoxide dismutase, lipid peroxidation, glutathione peroxidase, catalase levels and serum biochemical profile such as serum glutamate oxalate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, bilirubin and total protein were examined for the antioxidant and hepatoprotective effects of these treatments. The results of the present studies strongly indicate that the higher dose (400 mg/kg) of ethanolic extract of L. elephantum proved against hepatoprotective effects and also the antioxidant properties. DOI: http://dx.doi. org/10.3329/bjp.v9i3. 19704
Reduced Flow in Delayed Graft Function as Assessed by IVIM Is Associated With Time to Recovery Following Kidney Transplantation

Delayed graft function (DGF), defined as the need for dialysis in the first week after kidney transplantation, frequently complicates posttransplantation care. The most common cause of DGF is ischemia–reperfusion injury (IRI). To date, no clinical tools can accurately estimate its severity, nor the time required for recovery of kidney function.
Repeated grazing of a salt marsh grass by moulting greylag geese Anser anser– does sequential harvesting optimise biomass or protein gain?

The effects of simulated goose grazing on common saltmarsh-grass Puccinellia maritima plants were tested on a Danish salt marsh during the flightless moulting period of greylag geese Anser anser (3 21 June 1998). Plants in an area exclosed from the influence of grazing and the nutrient effects of goose faeccs were subject to removal of youngest lamina at 3-, 6-, 9- and 18-day intervals during this period. Average biomass and protein accumulation between harvests was highest at defoliation intervals of 9 days or more. Field observations from two separate study areas demonstrated geese returned to regraze the Puccinellia sward after 6-8 days and oesophageal contents from feeding geese shorted selection for lamina lengths consistent with the results of clipping every 6 days. Geese therefore regrazed Puccinellia patches at shorter intervals than expected were they to maximise their intake of biomass or protein at each visit. However, total cumulative lamina elongation, equivalent to the long term gain during the entire moult period, showed no significant difference between the three most intensive defoliation treatments, which were significantly greater than those of plants defoliated at 18 day intervals. Highest overall lamina protein levels were maintained at 6- and 9-day defoliation intervals. This suggests geese regrazed Puccinellia patches at a rate that maximised their number of harvests during the flightless period, but maintained highest protein levels and overall biomass in the sward. This suggests, in line with earlier studies, that moulting greylag geese combine dietary selection, reduced nitrogen excretion and regrazing patterns to meet protein demands during regrowth of flight feathers.
High‐efficiency transformation of archaea by direct PCR products with its application to directed evolution of a thermostable enzyme

Hyperthermophilic archaea with unique biochemical and physiological characteristics are important organisms for fundamental research of life science and have great potential for biotechnological applications. However, low transformation efficiency of foreign DNA molecules impedes developments in genetic modification tools and industrial applications. In this study, we applied prolonged overlap extension PCR (POE‐PCR) to generate multimeric DNA molecules and then transformed them into two hyperthermophilic archaea, Thermococcus kodakarensis KOD1 and Pyrococcus yayanosii A1. This study was the first example to demonstrate the enhanced transformation efficiencies of POE‐PCR products by a factor of approximately 100 for T. kodakarensis KOD1 and 8 for P. yayanosii A1, respectively, relative to circular shuttle plasmids. Furthermore, directed evolution of a modestly thermophilic enzyme, Methanothermococcus okinawensis 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGR), was conducted to obtain more stable ones due to high transformation efficiency of T. kodakarensis (i.e. ~3 × 104 CFU per μg DNA). T. kodakarensis harbouring the most thermostable MoHMGR mutant can grow in the presence of a thermostable antibiotic simvastatin at 85°C and even higher temperatures. This high transformation efficiency technique could not only help develop more hyperthermophilic enzyme mutants via directed evolution but also simplify genetical modification of archaea, which could be novel hosts for industrial biotechnology.
Productivity growth, technical efficiency, and technical change in China's soybean production

A stochastic frontier production function (SFPF) is specified to examine productivity growth, technical efficiency, and technical change in China’s soybean sector. A panel data set of 12 major soybean-producing provinces across the nation during the period of 1983 to 2007 was used. Results indicate that total factor productivity for China’s soybean production increased by 1.5% annually, with productivity growth, mainly, from technological progress. However, both technical efficiency and technical progress showed a decreasing trend through time. Clearly, market liberalization has produced negative impact on China’s soybean productivity. Key words: Stochastic frontier production function, total factor productivity, technical efficiency, technical change, China, soybean production.
Copepod guts as biogeochemical hotspots in the sea: Evidence from microelectrode profiling of Calanus spp

The environmental conditions inside the gut of Calanus hyperboreus and C. glacialis were measured with microelectrodes. An acidic potential hydrogen (pH) gradient was present in the gut of C. hyperboreus, and the lowest pH recorded was 5.40. The gut pH of a starved copepod decreased by 0.53 after the copepod resumed feeding for a few hours, indicating the secretion of acidic digestive fluid. A copepod feeding on Thalassiosira weissflogii (diatom) had slightly lower pH than that feeding on Rhodomonas salina (cryptophyte). Oxygen was undersaturated in the gut of both C. hyperboreus and C. glacialis, with a steep gradient from the anal opening to the metasome region. The central metasome region was completely anoxic. Food remains in the gut led to a lower oxygen level, and a diatom diet induced a stronger oxygen gradient than a cryptophyte diet. The acidic and suboxic–anoxic environments of the copepod gut may support iron dissolution and anaerobic microbial activities that otherwise are not favored in the well‐buffered and oxygenated ambient ocean.
Arousal-Biased Competition Explains Reduced Distraction by Reward Cues under Threat

Abstract Anxiety is an adaptive neural state that promotes rapid responses under heightened vigilance when survival is threatened. Anxiety has consistently been found to potentiate the attentional processing of physically salient stimuli. However, a recent study demonstrated that a threat manipulation reduces attentional capture by reward-associated stimuli, suggesting a more complex relationship between anxiety and the control of attention. The mechanisms by which threat can reduce the distracting quality of stimuli are unknown. In this study, using functional magnetic resonance imaging (fMRI) on human subjects, we examined the neural correlates of attention to previously reward-associated stimuli with and without the threat of unpredictable electric shock. We replicate enhanced distractor-evoked activity throughout the value-driven attention network (VDAN) in addition to enhanced stimulus-evoked activity generally under threat. Importantly, these two factors interacted such that the representation of previously reward-associated distractors was particularly pronounced under threat. Our results from neuroimaging fit well with the principle of arousal-biased competition (ABC), although such effects are typically associated with behavioral measures of increased attention to stimuli that already possess elevated attentional priority. The findings of our study suggest that ABC can be leveraged to support more efficient ignoring of reward cues, revealing new insights into the functional significance of ABC as a mechanism of attentional control, and provide a mechanistic explanation of how threat reduces attention to irrelevant reward information.
Production of perdeuterated fucose from glyco-engineered bacteria

Abstract l-Fucose and l-fucose-containing polysaccharides, glycoproteins or glycolipids play an important role in a variety of biological processes. l-Fucose-containing glycoconjugates have been implicated in many diseases including cancer and rheumatoid arthritis. Interest in fucose and its derivatives is growing in cancer research, glyco-immunology, and the study of host–pathogen interactions. l-Fucose can be extracted from bacterial and algal polysaccharides or produced (bio)synthetically. While deuterated glucose and galactose are available, and are of high interest for metabolic studies and biophysical studies, deuterated fucose is not easily available. Here, we describe the production of perdeuterated l-fucose, using glyco-engineered Escherichia coli in a bioreactor with the use of a deuterium oxide-based growth medium and a deuterated carbon source. The final yield was 0.2 g L−1 of deuterated sugar, which was fully characterized by mass spectrometry and nuclear magnetic resonance spectroscopy. We anticipate that the perdeuterated fucose produced in this way will have numerous applications in structural biology where techniques such as NMR, solution neutron scattering and neutron crystallography are widely used. In the case of neutron macromolecular crystallography, the availability of perdeuterated fucose can be exploited in identifying the details of its interaction with protein receptors and notably the hydrogen bonding network around the carbohydrate binding site.
PHYLOGENETIC RELATIONSHIPS OF THE RED-BELLIED GRACKLE (ICTERIDAE: HYPOPYRRHUS PYROHYPOGASTER) INFERRED FROM MITOCHONDRIAL DNA SEQUENCE DATA

Abstract The phylogenetic affinities of the Red-bellied Grackle (Hypopyrrhus pyrohypogaster), a Colombian endemic and the only member of this genus, are enigmatic. Based on phylogenetic analyses of sequences from the cytochrome b and ND2 mitochondrial genes, we present a first hypothesis on the systematic position of Hypopyrrhus. In so doing, we complete the sampling at the genus level for a published phylogeny of New World blackbirds (Johnson and Lanyon 1999). Hypopyrrhus belongs in a clade composed of mostly South American species within the grackles and allies assemblage, one of the five main lineages in the Icteridae. Within this lineage, Hypopyrrhus is consistently placed in a clade with Gymnomystax mexicanus and Lampropsar tanagrinus, but parsimony and maximum-likelihood reconstructions do not agree on which of these species is its sister taxon. Vocal and morphological data suggest that Hypopyrrhus and Gymnomystax are likely sister taxa. The addition of Hypopyrrhus does not cause major topological changes to Johnson and Lanyon's (1999) phylogeny of the grackles and allies; thus, the conclusions of evolutionary studies that used this phylogeny as a baseline remain largely unaltered. Relaciones Filogenéticas de Hypopyrrhus pyrohypogaster (Icteridae) Inferidas a Partir de Secuencias de ADN Mitocondrial Resumen. Las afinidades filogenéticas de Hypopyrrhus pyrohypogaster, el único miembro de este género endémico de Colombia, son enigmáticas. En este estudio establecemos la posición sistemática de Hypopyrrhus con base en análisis filogenéticos de secuencias de los genes mitocondriales citocromo b y ND2. Además, completamos el muestreo a nivel genérico para una filogenia del grupo publicada por Johnson y Lanyon (1999). Hypopyrrhus pertenece a un clado compuesto principalmente por especies suramericanas dentro del grupo de los changos y chamones, uno de los cinco clados principales de los Icteridae. Dentro de este grupo, Hypopyrrhus se ubica consistentemente en un clado junto con Gymnomystax mexicanus y Lampropsar tanagrinus, pero las reconstrucciones de parsimonia y máxima verosimilitud se contradicen en cuanto a cuál de estas especies es su taxón hermano. Datos de vocalizaciones y morfología sugieren que Hypopyrrhus y Gymnomystax son probablemente géneros hermanos. La incorporación de Hypopyrrhus a la filogenia de Johnson y Lanyon (1989) no causó cambios topoló gicos importantes, por lo que las conclusiones de los estudios evolutivos que usaron esta filogenia como base no fueron alteradas.
Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

Current chemotherapy for colorectal cancer (CRC) includes the use of oxaliplatin (Oxa), a first-line cytotoxic drug which, in combination with irinotecan/5-fluorouracil or biologic agents, increases the survival rate of patients. However, the administration of this drug induces side effects that limit its application in patients, making it necessary to develop new tools for targeted chemotherapy. MamC-mediated biomimetic magnetic nanoparticles coupled with Oxa (Oxa-BMNPs) have been previously demonstrated to efficiently reduce the IC50 compared to that of soluble Oxa. However, their strong interaction with the macrophages revealed toxicity and possibility of aggregation. In this scenario, a further improvement of this nanoassembly was necessary. In the present study, Oxa-BMNPs nanoassemblies were enveloped in phosphatidylcholine unilamellar liposomes (both pegylated and non-pegylated). Our results demonstrate that the addition of both a lipid cover and further pegylation improves the biocompatibility and cellular uptake of the Oxa-BMNPs nanoassemblies without significantly reducing their cytotoxic activity in colon cancer cells. In particular, with the pegylated magnetoliposome nanoformulation (a) hemolysis was reduced from 5% to 2%, being now hematocompatibles, (b) red blood cell agglutination was reduced, (c) toxicity in white blood cells was eliminated. This study represents a truly stepforward in this area as describes the production of one of the very few existing nanoformulations that could be used for a local chemotherapy to treat CRC.
Effects of Excessive Supplemental Fat on Feedlot Cattle Growth Performance and Digestive Function

Abstract Ninety medium-framed crossbred steers (245 kg) were used in a 205-d feeding trial to evaluate the influence of 4, 8, and 12% supplemental fat (tallow soap stock) on feedlot growth performance. Increasing level of fat supplementation depressed ADG ( P P P P m was 1.00 with 4% supplemental fat and declined ( P m of tallow soap stock declined in a near rectilinear fashion from 5.65 Mcal/kg at the 4% level of supplementation to 2.85 Mcal/kg at the 12% level of supplementation. Six Holstein steers (296 kg) with T cannulas in the rumen and proximal duodenum were used to evaluate treatment effects on digestive function. Ruminal digestion of OM ( P P P .10) postruminal digestion of OM, ADF, starch, and N. Postruminal digestion of lipid decreased ( P P
Cultural Adaptation and Validation of the Korean Version of the iMTA Productivity Cost Questionnaire

This study develops the Korean version of the Institute for Medical Technology Assessment Productivity Cost Questionnaire (iPCQ) through translation/cultural adaptation and evaluation of psychometric properties. We included 110 outpatients visiting a gynecology clinic. We conducted the translation and cross-cultural adaptation of the iPCQ, including forward and back-translation, pilot test with cognitive debriefing, and finalization. We analyzed the feasibility (using average time of filling in the iPCQ and the proportion of missing values), test–retest reliability (using the intra-class correlation coefficient [ICC]), and validity (concurrent validity with the Work Productivity and Activity Impairment [WPAI] and construct validity with the 36-Item Short Form Survey [SF-36], using Spearman’s ρ). The Korean version of iPCQ showed appropriate feasibility (average filling in time was 5.0 min without missing values), and had excellent values in the domains of absenteeism, presenteeism, and unpaid work for test–retest reliability (ICC: 0.92–0.99). For concurrent validity, the Korean version of iPCQ showed moderate–high correlation for absenteeism and presenteeism with the WPAI. All domains of productivity losses measured by the Korean version of iPCQ showed negative correlation with the quality of life estimated by the SF-36. Through this study, we developed a Korean instrument that can measure and value health-related productivity losses including unpaid work as well as absenteeism and presenteeism.
Rapid and transient response of soil respiration to rain

The influence of rainstorm on soil respiration of a mixed forest in southern New England, USA was investigated with eddy covariance, rain simulation and laboratory incubation. Soil respiration is shown to respond rapidly and instantaneously to the onset of rain and return to the prerain rate shortly after the rain stops. The pulse‐like flux, most likely caused by the decomposition of active carbon compounds in the litter layer, can amount to a loss of 0.18 t C ha−1 to the atmosphere in a single intensive storm, or 5–10% of the annual net ecosystem production of midlatitude forests. If precipitation becomes more variable in a future warmer world, the rain pulse should play an important part in the transient response of the ecosystem carbon balance to climate, particularly for ecosystems on ridge‐tops with rapid water drainage.
Allopregnanolone restores the tyrosine hydroxylase‐positive neurons and motor performance in a 6‐OHDA‐injected mouse model

It has been reported that allopregnanolone (APα) promotes the neurogenesis of the neural progenitor cells (NPCs) in the subventricular zone (SVZ) and prevents the decrease of dopaminergic neurons in 6‐hydroxydopamine (6‐OHDA)‐treated mice by binding to γ‐aminobutyric acid A receptor (GABAAR) and then opening voltage‐gated L‐type Ca2+ channel, but the underlying mechanisms remain elusive. The aim of this study was to explore the possible involvement of GABAAR and calcium/calmodulin‐dependent protein kinase II delta 3 (CaMKIIδ3) in this process.
Applying Machine Learning to Daily-Life Data From the TrackYourTinnitus Mobile Health Crowdsensing Platform to Predict the Mobile Operating System Used With High Accuracy: Longitudinal Observational Study

Background Tinnitus is often described as the phantom perception of a sound and is experienced by 5.1% to 42.7% of the population worldwide, at least once during their lifetime. The symptoms often reduce the patient’s quality of life. The TrackYourTinnitus (TYT) mobile health (mHealth) crowdsensing platform was developed for two operating systems (OS)—Android and iOS—to help patients demystify the daily moment-to-moment variations of their tinnitus symptoms. In all platforms developed for more than one OS, it is important to investigate whether the crowdsensed data predicts the OS that was used in order to understand the degree to which the OS is a confounder that is necessary to consider. Objective In this study, we explored whether the mobile OS—Android and iOS—used during user assessments can be predicted by the dynamic daily-life TYT data. Methods TYT mainly applies the paradigms ecological momentary assessment (EMA) and mobile crowdsensing to collect dynamic EMA (EMA-D) daily-life data. The dynamic daily-life TYT data that were analyzed included eight questions as part of the EMA-D questionnaire. In this study, 518 TYT users were analyzed, who each completed at least 11 EMA-D questionnaires. Out of these, 221 were iOS users and 297 were Android users. The iOS users completed, in total, 14,708 EMA-D questionnaires; the number of EMA-D questionnaires completed by the Android users was randomly reduced to the same number to properly address the research question of the study. Machine learning methods—a feedforward neural network, a decision tree, a random forest classifier, and a support vector machine—were applied to address the research question. Results Machine learning was able to predict the mobile OS used with an accuracy up to 78.94% based on the provided EMA-D questionnaires on the assessment level. In this context, the daily measurements regarding how users concentrate on the actual activity were particularly suitable for the prediction of the mobile OS used. Conclusions In the work at hand, two particular aspects have been revealed. First, machine learning can contribute to EMA-D data in the medical context. Second, based on the EMA-D data of TYT, we found that the accuracy in predicting the mobile OS used has several implications. Particularly, in clinical studies using mobile devices, the OS should be assessed as a covariate, as it might be a confounder.