Miracle-dz/UniFAR-FTUs huggingface dataset:
Production, Manufacturing and Logistics Dynamic pricing with real-time demand learning

In many service industries, the firm adjusts the product price dynamically by taking into account the current product inventory and the future demand distribution. Because the firm can easily monitor the product inventory, the success of dynamic pricing relies on an accurate demand forecast. In this paper, we consider a situation where the firm does not have an accurate demand forecast, but can only roughly estimate the customer arrival rate before the sale begins. As the sale moves forward, the firm uses real-time sales data to fine-tune this arrival rate estimation. We show how the firm can first use this modified arrival rate estimation to forecast the future demand distribution with better precision, and then use the new information to dynamically adjust the product price in order to maximize the expected total revenue. Numerical study shows that this strategy not only is nearly optimal, but also is robust when the true customer arrival rate is much different from the original forecast. Finally, we extend the results to four situations commonly encountered in practice: unobservable lost customers, time dependent arrival rate, batch demand, and discrete set of allowable prices.
Rational Antimicrobial Use in an Intensive Care Unit in Jakarta, Indonesia: A Hospital-Based, Cross-Sectional Study

Purpose : To analyze the rationality of antimicrobial usage and factors influencing it over the period of January to December 2010 in Fatmawati General Hospital, Jakarta, Indonesia. Methods : Present study was conducted in the intensive care unit of Fatmawati General Hospital, Jakarta, Indonesia. Gyssens method was used to assess the rationality of antimicrobial use. Data for this retrospective, cross-sectional study were drawn from patients’ medical record files. Multivariate analysis with ordinal logistic regression was used to determine the dominant factors affecting the appropriateness of antimicrobial use. Results : Data for 410 patients from the intensive care unit (ICU) was collected. There were 912 antimicrobial regimens prescribed for these patients. Based on Gyssens method, 805 antimicrobial regimens were empirical and 107 definitive. Of the empirical regimens, 596 (74.03 %) were inappropriate, while of the definitive regimens, 84 (78.51 %) were inappropriate. Site of infection, comorbid conditions and economic status of patients were the main factors that influenced the appropriateness of antimicrobial treatment choice. Conclusion : A higher degree of irrational use of antimicrobial agents occurs in the ICU of the hospital studied, this can lead to increase in the burden of disease. Keywords : Rational use, Antimicrobial, Empirical treatment, Gyssens method, Intensive care
Receptive fields and functional architecture of macaque V2.

1. Visual area V2 of macaque monkey cerebral cortex is the largest of the extrastriate visual areas, yet surprisingly little is known of its neuronal properties. We have made a quantitative analysis of V2 receptive field properties. Our set of measurements was chosen to distinguish neuronal responses reflecting parvocellular (P) or magnocellular (M) inputs and to permit comparison with similar measurements made in other visual areas; we further describe the relationship of those properties to the laminar and cytochrome oxidase (CO) architecture of V2. 2. We recorded the activity of single units representing the central 5 degrees in all laminae and CO divisions of V2 in anesthetized, paralyzed macaque monkeys. We studied responses to geometric targets and to drifting sinusoidal gratings that varied in orientation, spatial frequency, drift rate, contrast, and color. 3. The orientation selectivity and spatial and temporal tuning of V2 neurons differed little from those in V1. As in V1, spatial and temporal tuning in V2 appeared separable, and we identified a population of simple cells (more common within the central 3 degrees) similar to those found in V1. Contrast sensitivity of V2 neurons was greater on average than in V1, perhaps reflecting the summation of inputs in V2's larger receptive fields. Many V2 neurons exhibited some degree of chromatic opponency, responding to isoluminant color variations, but these neurons differed from V1 in the linearity with which they summate cone signals. 4. In agreement with others, we found that neurons with selective responses to color, size, and motion did seem to cluster in different CO compartments. However, this segregation of qualitatively different response selectivities was not absolute, and response properties also seemed to depend on laminar position within each compartment. As others also have noted, we found that CO stripe widths in the macaque (unlike in the squirrel monkey) did not consistently appear different. We relied on the segregation of qualitatively distinct cell types, and in some cases the pattern of Cat-301 staining as well, to distinguish CO stripes when the staining pattern of CO alone was ambiguous. Although all cell types were found in all CO compartments and laminae, unoriented cells were more prominent in layers 2-4 of "thin" stripes, direction-selective cells in layers 3B/4 of "thick" stripes, color-selective cells in the upper layers of thin and pale stripes, and end-stopped cells mainly outside of layer 4 in thin stripes. (ABSTRACT TRUNCATED AT 400 WORDS)
Accelerated focused crawling through online relevance feedback

The organization of HTML into a tag tree structure, which is rendered by browsers as roughly rectangular regions with embedded text and HREF links, greatly helps surfers locate and click on links that best satisfy their information need. Can an automatic program emulate this human behavior and thereby learn to predict the relevance of an unseen HREF target page w.r. t. an information need, based on information limited to the HREF source page? Such a capability would be of great interest in focused crawling and resource discovery, because it can fine-tune the priority of unvisited URLs in the crawl frontier, and reduce the number of irrelevant pages which are fetched and discarded.
Heteroduplex Analysis of Causative APC Mutations in FAP Patients Referred for Genetic Counseling in Mashhad Ghaem Hospital, Iran

Since the isolation and characterization of the adenomatous polyposis coli (APC) gene in 1991, none of the currently available techniques were able to detect 100% of the germline mutations. In the present study we have used Heteroduplex Analysis (HA) and followed by DNA sequencing to test in an exhaustive analysis of entire APC coding region in a group of 26 unrelated Khorasanies patients with familial adenomatous polyposis (FAP). Sixtheen causative mutations (61.5%) were detected. This study shows that HA is less sensitive for single base pair substitutions, whereas mutations related to insertions or deletions are easier to detect by the HA method. Since more than 70% of APC mutations are small deletion (66%) or small insertions (6%), therefore HA is particularly suitable for the APC mutation detection.
Resilient Datacenter Load Balancing in the Wild

Production datacenters operate under various uncertainties such as traffic dynamics, topology asymmetry, and failures. Therefore, datacenter load balancing schemes must be resilient to these uncertainties; i.e., they should accurately sense path conditions and timely react to mitigate the fallouts. Despite significant efforts, prior solutions have important drawbacks. On the one hand, solutions such as Presto and DRB are oblivious to path conditions and blindly reroute at fixed granularity. On the other hand, solutions such as CONGA and CLOVE can sense congestion, but they can only reroute when flowlets emerge; thus, they cannot always react timely to uncertainties. To make things worse, these solutions fail to detect/handle failures such as blackholes and random packet drops, which greatly degrades their performance. In this paper, we introduce Hermes, a datacenter load balancer that is resilient to the aforementioned uncertainties. At its heart, Hermes leverages comprehensive sensing to detect path conditions including failures unattended before, and it reacts using timely yet cautious rerouting. Hermes is a practical edge-based solution with no switch modification. We have implemented Hermes with commodity switches and evaluated it through both testbed experiments and large-scale simulations. Our results show that Hermes achieves comparable performance to CONGA and Presto in normal cases, and well handles uncertainties: under asymmetries, Hermes achieves up to 10% and 20% better flow completion time (FCT) than CONGA and CLOVE; under switch failures, it outperforms all other schemes by over 32%.
The Relationships of Prison Climate to Health Service in Correctional Environments: Inmate Health Care Measurement, Satisfaction and Access in Prisons

Correctional institutions which are characterised by authoritarian organisation may control access to health care services through filtering requests through correctional staff, or conversely by using staff to identify and facilitate inmate medical care. We investigated the relationship between inmate‐assessed prison social climate and satisfaction with health care in over 4,800 male and female inmates in 49 English/Welsh correctional institutions (ranging from high to low security). A single eleven‐item dimension of health care satisfaction was identified in the Measuring the Quality of Prison Life (MQPL) instrument. Multiple regression of the dimensions of prison climate as measured by the MQPL on health care satisfaction indicated that the scales ‘Relationships with staff’, ‘Safety’, ‘Feedback and care’, ‘Fairness’ and ‘Care for vulnerable’, predicted 30% of variance in health care satisfaction. Qualitative data on health care issues from a parallel study of twelve English/Welsh local prisons were used to explicate the quantitative findings. Data suggest that positive prison climates facilitated interactions between correctional and health care staff and prisoners, while in negative climates correctional staff acted as a filter or barrier between inmates and health services. Further, data suggested that health care staff themselves may be influenced by prison climate. These findings implicate health care provision and access as an integral part of prison climate, and suggest that inmates' judgments on access to, and satisfaction with, prison health services are significantly associated with general, non‐health related prison climate measures.
Arthroscopic biceps tenodesis: a new technique using bioabsorbable interference screw fixation.

Abstract Purpose: To report a new technique of arthroscopic biceps tenodesis using bioabsorbable interference screw fixation and the early results. Type of Study: Prospective, nonrandomized study. Methods: Technique: The principle of arthroscopic biceps tenodesis is simple: after biceps tenotomy, the tendon is exteriorized and doubled on a suture; the biceps tendon is then pulled into a humeral socket (7 or 8 mm × 25 mm) drilled at the top of the bicipital groove, and fixed using a bioabsorbable interference screw (8 or 9 mm × 25 mm) under arthroscopic control. Patients: 43 patients treated with this technique between 1997 and 1999 were followed-up for at least 1 year. The technique was indicated in 3 clinical situations: (1) with arthroscopic cuff repair (3 cases), (2) in case of isolated pathology of the biceps tendon with an intact cuff (6 cases), and (3) as an alternative to biceps tenotomy in patients with massive, degenerative and irreparable cuff tears (34 cases). The biceps pathology was tenosynovitis (4 cases), prerupture (15 cases), subluxation (11 cases), and luxation (13 cases). Results: The absolute Constant score improved from 43 points preoperatively to 79 points at review ( P Conclusions: Arthroscopic biceps tenodesis using bioabsorbable screw fixation is technically possible and gives good clinical results. This technique can be used in cases of isolated pathologic biceps tendon or a cuff tear. A very thin, fragile, almost ruptured biceps tendon is the technical limit of this arthroscopic technique. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 18, No 9 (November-December), 2002: pp 1002– 1012
Complete mitochondrial genome of Sipunculus nudus (Sipuncula, Sipunculidae)

Abstract In this paper, the complete mitochondrial (mt) genome of Sipunculus nudus collected from the coast of southeast China was determined. The complete mt genome was 15,376 bp in length, including 13 protein-coding genes, 2 rRNA genes, 23 tRNA genes, and a putative control region (CR). The overall base composition of the H-strand is 29.25% A, 28.78% T, 27.19% C, and 14.78% G, with an AT content of 58.03%. The mt DNA of Chinese S. nudus shared 73.6% and 60.2% identities with that of French S. nudus (GenBank accession number: FJ42,2961) and Chinese Phascolosoma esculenta (GenBank accession number: EF58,3817), respectively.
Outcomes of Individuals with Spinal Cord Injury Served by State Vocational Rehabilitation Services

Consumers with spinal cord injury (SCI) served by state vocational rehabilitation services programs receive a variety of services to help them achieve competitive employment and higher earning outcomes. The purpose of this study was twofold: (a) to determine whether there was a relationship between specific vocational rehabilitation (VR) services and vocational outcomes (i.e., competitive employment and weekly earnings) at closure and (b) to establish whether there was a relationship between specific demographic variables and vocational outcomes (i.e., competitive employment and weekly earnings) at closure. The RSA-911 data for fiscal year 2006 were analyzed. The analysis of specific VR service variables indicated job placement, maintenance, and rehabilitation technology were significantly related to competitive employment of consumers with SCI. However, rehabilitation technology was negatively related to competitive employment. Vocational rehabilitation counseling and guidance, college/university training, and rehabilitation technology were positively related to weekly earnings; whereas occupational/vocational training, on-the-job training, and job placement services were negatively related to weekly earnings. An analysis of demographic variables indicated that gender and age were not related to competitive employment. Level of education and race were related to competitive employment. Gender, age, educational level, and race were related to weekly earnings. Males, young consumers, consumers with most education, and Whites were more likely to earn higher salaries.
The Impact of Childhood Chronic Illness on the Family: Psychosocial Adjustment of Siblings

Chronic illness is a multifaceted concept that significantly impacts millions of families and siblings each year. The biopsychosocial model shows that illness involves more than the biological and medical processes; it includes psychosocial implications on families as well. The purpose of this qualitative and quantitative study was to examine the effects of childhood chronic illness on families and siblings by exploring the positive and negative consequences from parents’ perspectives, the extent to which families experienced illness-related stress and strain, as well as further examining the specific ways in which families adapt their lives. This study specifically sought to explore the relationship between the impact on siblings and the impact on the family. By surveying parents associated with supportive non-profit organizations, this research sought to answer those questions. This study found that illness severity and the level of stress were statistically significant in their impact on the family. This study also found a positive correlation that showed illness’ impact on the family invariably impacts the siblings. The qualitative portion of this study illustrates how parents convey thoughtful, enlightening, and unique perspectives from their day-to-day lives and experiences. Social workers, Child Life Specialists, and other health care professionals need to be aware of the psychosocial implications of illness and its impact on families so that they can properly assess and provide intervention when necessary. Professionals should also be aware of and utilize a family systems perspective when working with chronically ill children and their families.
EWnFM: An Environment States Oriented Web Service Non-Functional Property Model

A proper model of Web service non-functional properties is the key foundation to the evaluation of non-functional properties of Adaptive Service Based Software (ASBS) systems. As the environment in which a Web service is deployed may keep changing, environmental factors would affect the non-functional properties of a Web service a lot. However, available non-functional property models usually ignore the impact of environmental factors, leading to insufficient modeling power of non-functional properties, limited effect of system wide non-functional property evaluation based on these models, and the inability to support environment states oriented specifications of ASBS. This paper propose an environment states oriented Web service non-functional property model. By considering the differences of a non-functional property under different environment states, environment states of a Web service is analyzed using a Dirichlet process based method. With such a foundation, an environment states oriented Web service non-functional property model is introduced, together with the parameter estimation methods based on historical monitor data. Experiment results have shown that compared to the evaluated methods, our model could generate data that are much close to real monitored data.
Author response: Pressure wave dosimetry for "Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury".

We would like to thank Lund and Rule for their interest in our work and their helpful suggestions to more thoroughly characterize the blast wave that we generated in our system. In order to accomplish that goal, we designed pressure measurement software coupled with a high-frequency pressure sensor (model 102B16; PCB Piezotronics) and signal conditioner (model 482C05; PCB Piezotronics, Depew, NY). Using this software we have been able to successfully characterize the total blast pressure in our system (Fig. A) adjacent to the animal holder at the level of the head (Fig. B). We now report measurements, obtained by using this system, of the intensity of our blast wave, which was 149.8 6 2.09 kPa at the gauge (n 1⁄4 13 blast responses; mean 6 SEM). The total duration of the total pressure in our system (blast wave þ wind gust) was approximately 10 to 15 ms, similar to that reported by Goldstein et al. We feel that our blast exposure paradigm results in a phenotype that best reflects ocular injury after a traumatic brain injury, as recently described. The authors raise an interesting point regarding the complexity of the blast wave responses experienced in our blast tank. It is likely in our system that the subjects experience a complex blast wave. It is also entirely likely, however, that veterans or civilians exposed to blast waves also experience complex blast waves.
Recent advances in anogenital antiretroviral microbicides and multimodal delivery systems.

The predominant route of human immunodeficiency virus type 1 (HIV-1) transmission is across the vaginal and rectal epithelia during sexual intercourse. Yet the development of safe and clinically effective vaginal and rectal antiretroviral microbicides remains an unmet challenge despite more than 25 years of accelerated product development. The clinical failure of seven microbicide candidates points to major unresolved challenges associated with target specificity, safety, potency as well as drug-delivery of validated candidates undergoing preclinical and clinical development as anogenital microbicides. Currently, additional antiretroviral agents are sought as anogenital microbicides to provide potential anti-HIV protection by directly inactivating HIV-1, preventing HIV-1 from attaching, entering or replicating in susceptible target cells, and/or by hindering the dissemination of HIV-1 to the host cells that line the vaginal/rectal walls along with targeting novel HIV-host dependency factors. Among the several types of anti-HIV microbicides currently in preclinical and clinical development, only one clinical trial of an HIV-1 reverse transcriptase inhibitor has shown clinical promise as a potential microbicide. This article reviews the preclinical/ clinical efficacy and safety profiles of current antiretroviral microbicide candidates (Tenofovir, Stampidine, UC-781, Dapivirine/TMC120, MIV-150, HI-443, CCR5 antagonists, neutralizing antibodies, targeted RNA interference, RNA- based aptamers, Aptamer-siRNA-chimeric RNA), as well as advances in multimodal microbicide delivery systems (nanocarriers - liposomes, dendrimers, polymeric, solid lipid and metal nanoparticles, nanospheres, nanocapsules, intravaginal rings and recombinant lactobacilli delivery strategies). The clinical failure of first-generation antiretroviral gels is spearheading efforts to evaluate new mechanism-based antiretrovirals with a rational design and engineering of long-acting and novel delivery systems more appropriate to curb anogenital HIV transmission.
First Trimester Diagnosis of Omphalocele

Normal physiologic herniation of the fetal bowel is often seen on first trimester sonogram. An omphalocele is an abdominal wall defect that occurs as a result of herniation into the umbilical cord and is often associated with chromosomal anomalies. This case report presents an omphalocele seen in the first trimester and discusses how to differentiate this finding from normal physiologic bowel herniation.
Time-Varying Procedures for Insulin-Dependent Diabetes Mellitus Control

This work considers the problem of automatically controlling the glucose level in insulin dependent diabetes mellitus (IDDM) patients. The objective is to include several important and practical issues in the design: model uncertainty, time variations, nonlinearities, measurement noise, actuator delay and saturation, and real time implementation. These are fundamental issues to be solved in a device implementing this control. Two time-varying control procedures have been proposed which take into consideration all of them: linear parameter varying (LPV) and unfalsified control (UC). The controllers are implemented with low-order dynamics that adapt continuously according to the glucose levels measured in real time in one case (LPV) and by controller switching based on the actual performance in the other case (UC). Both controllers have performed adequately under all these practical restrictions, and a discussion on pros and cons of each method is presented at the end.