Miracle-dz/UniFAR-FTUs huggingface dataset:
Specific biomarkers of internalizing and externalizing characteristics among first-time driving while impaired offenders

Studies have described the externalizing (e.g., antisocial propensity) and internalizing (e.g., anxiety, depression) characteristics of driving while impaired (DWI) recidivism. However, the respective contribution of those characteristics to recidivism risk and their underlying mechanisms are still unknown. Cortisol, a stress hormone, is a biomarker underlying various high-risk characteristics. Studies have found that first-time DWI (fDWI) offenders and recidivists have lower cortisol reactivity (CR) than non-DWI drivers. In other high-risk populations, internalizing characteristics has been positively correlated to cortisol basal levels (CBL). To disentangle the distinct recidivism trajectories in the fDWI offender population, this study explored whether cortisol measures were markers of externalizing and internalizing characteristics. Male fDWI offenders were recruited and submitted to the following protocols: Millon Clinical Multiaxial Inventory (antisocial tendency, anxiety, depression); Addiction Severity Index (major driving violations, criminal arrests); Sensation Seeking Scale; Barratt Impulsivity Scale and salivary cortisol measured after a psychosocial stress task and during a resting day. Cluster analyses and ANOVA were performed. fDWI offenders with higher externalizing propensity have a lower CR compared to offenders with lower propensity. Moreover, CBL is higher among offenders with higher versus lower internalizing propensity. The current study revealed dissimilar associations between cortisol measures and externalizing and internalizing propensity among fDWI offenders. These results suggested that externalizing and internalizing characteristics, two high-risk dimensions associated to DWI recidivism, involved in specific underlying mechanisms. Increasing knowledge on these underlying mechanisms may more precisely explain the various etiological pathways to DWI recidivism.
Value from Regulatory Construal Fit: The Persuasive Impact of Fit between Consumer Goals and Message Concreteness

This research investigates the relationship between regulatory focus and construal level. The findings indicate that promotion-focused individuals are more likely to construe information at abstract, high levels, whereas those with a prevention focus are more likely to construe information at concrete, low levels (experiments 1 and 2). Further, such fit (vs. nonfit) between an individual's regulatory focus and the construal level at which information is represented leads to more favorable attitudes (experiments 3 and 4) and enhances performance on a subsequent task (experiment 3). These outcomes occur because fit enhances engagement that in turn induces processing fluency and intensifies reactions. (c) 2009 by JOURNAL OF CONSUMER RESEARCH, Inc.
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin.

RATIONALE Patients who developed acute respiratory distress syndrome (ARDS) after infection with severe respiratory viruses (e.g., severe acute respiratory syndrome-coronavirus, H5N1 avian influenza virus), exhibited unusually high levels of CXCL10, which belongs to the non-ELR (glutamic-leucine-arginine) CXC chemokine superfamily. CXCL10 may not be a bystander to the severe virus infection but may directly contribute to the pathogenesis of neutrophil-mediated, excessive pulmonary inflammation. OBJECTIVES We investigated the contribution of CXCL10 and its receptor CXCR3 axis to the pathogenesis of ARDS with nonviral and viral origins. METHODS We induced nonviral ARDS by acid aspiration and viral ARDS by intratracheal influenza virus infection in wild-type mice and mice deficient in CXCL10, CXCR3, IFNAR1 (IFN-α/β receptor 1), or TIR domain-containing adaptor inducing IFN-β (TRIF). MEASUREMENTS AND MAIN RESULTS We found that the mice lacking CXCL10 or CXCR3 demonstrated improved severity and survival of nonviral and viral ARDS, whereas mice that lack IFNAR1 did not control the severity of ARDS in vivo. The increased levels of CXCL10 in lungs with ARDS originate to a large extent from infiltrated pulmonary neutrophils, which express a unique CXCR3 receptor via TRIF. CXCL10-CXCR3 acts in an autocrine fashion on the oxidative burst and chemotaxis in the inflamed neutrophils, leading to fulminant pulmonary inflammation. CONCLUSIONS CXCL10-CXCR3 signaling appears to be a critical factor for the exacerbation of the pathology of ARDS. Thus, the CXCL10-CXCR3 axis could represent a prime therapeutic target in the treatment of the acute phase of ARDS of nonviral and viral origins.
Secure Sketch Search for Document Similarity

Document similarity search is an important problem that has many applications especially in outsourced data. With the wide spread of cloud computing, users tend to outsource their data to remote servers which are not necessarily trusted. This leads to the problem of protecting the privacy of sensitive data. We design and implement two secure similarity search schemes for textual documents utilizing locality sensitive hashing techniques for cosine similarity. While the first one provides very fast search time results and a decent level of privacy, the second method enjoys enhanced security properties such as hiding the search and access patterns but with higher latency.
Morphogenetic Proteins SpoVID and SafA Form a Complex during Assembly of the Bacillus subtilis Spore Coat

ABSTRACT During endospore formation in Bacillus subtilis, over two dozen polypeptides are assembled into a multilayered structure known as the spore coat, which protects the cortex peptidoglycan (PG) and permits efficient germination. In the initial stages of coat assembly a protein known as CotE forms a ring around the forespore. A second morphogenetic protein, SpoVID, is required for maintenance of the CotE ring during the later stages, when most of proteins are assembled into the coat. Here, we report on a protein that appears to associate with SpoVID during the early stage of coat assembly. This protein, which we call SafA for SpoVID-associated factor A, is encoded by a locus previously known as yrbA. We confirmed the results of a previous study that showed safA mutant spores have defective coats which are missing several proteins. We have extended these studies with the finding that SafA and SpoVID were coimmunoprecipitated by anti-SafA or anti-SpoVID antiserum from whole-cell extracts 3 and 4 h after the onset of sporulation. Therefore, SafA may associate with SpoVID during the early stage of coat assembly. We used immunogold electron microscopy to localize SafA and found it in the cortex, near the interface with the coat in mature spores. SafA appears to have a modular design. The C-terminal region of SafA is similar to those of several inner spore coat proteins. The N-terminal region contains a sequence that is conserved among proteins that associate with the cell wall. This motif in the N-terminal region may target SafA to the PG-containing regions of the developing spore.
Improving Fault Ride-Through Capability of Fixed-Speed Wind Turbine by Using Bridge-Type Fault Current Limiter

The interaction between wind turbines and grid results in increasing short-circuit level and fault ride-through (FRT) capability problem during fault condition. In this paper, the bridge-type fault current limiter (FCL) with discharging resistor is used for solving these problems. For this FCL, a control scheme is proposed, which uses the dc reactor current as control variable, to adjust the terminal voltage of induction generator (IG) without measuring any parameters of system. In this paper, the wind energy conversion system (WECS) is a fixed-speed system equipped with a squirrel-cage IG. The drivetrain is represented by a two-mass model. The analytical and simulation studies of the bridge-type FCL and proposed control scheme for limiting the fault current and improving FRT capability are presented and compared with the impact of the application of the series dynamic braking resistor (SDBR).
The role of correlated prices in demand response: A robust optimization approach

The use of robust optimization techniques for scheduling consumption in a demand response context is analyzed in this paper, with aid of results from a particular case study, in which energy prices of different time periods are highly correlated. Results indicate that it is of great importance to employ a solution approach that correctly models the correlation among prices of different periods over which consumption is to be scheduled. One such approach is proposed and investigated in this paper, with positive results.
A 100 kHz Time-Resolved Multiple-Probe Femtosecond to Second Infrared Absorption Spectrometer

We present a dual-amplifier laser system for time-resolved multiple-probe infrared (IR) spectroscopy based on the ytterbium potassium gadolinium tungstate (Yb:KGW) laser medium. Comparisons are made between the ytterbium-based technology and titanium sapphire laser systems for time-resolved IR spectroscopy measurements. The 100 kHz probing system provides new capability in time-resolved multiple-probe experiments, as more information is obtained from samples in a single experiment through multiple-probing. This method uses the high repetition-rate probe pulses to repeatedly measure spectra at 10 µs intervals following excitation allowing extended timescales to be measured routinely along with ultrafast data. Results are presented showing the measurement of molecular dynamics over >10 orders of magnitude in timescale, out to 20 ms, with an experimental time response of <200 fs. The power of multiple-probing is explored through principal component analysis of repeating probe measurements as a novel method for removing noise and measurement artifacts.
Disease activity, behavioral dysfunction, and health‐related quality of life in adolescents with inflammatory bowel disease

Background: Approximately 20%‐25% of all inflammatory bowel disease (IBD) cases have an onset in childhood or adolescence. Beyond disease severity, little is known regarding determinants of health‐related quality of life (HRQOL) in this population. This study aimed to identify behavioral correlates of HRQOL and examine behavioral/emotional dysfunction (e.g., internalizing/externalizing symptoms) as the mechanism through which disease severity impacts HRQOL. Methods: In all, 62 adolescents (mean = 15.47 years, standard deviation [SD] = 1.42) with IBD (79% Crohn's disease) and their parents were recruited from one of two pediatric IBD specialty clinics located in the Midwest or Northeast region of the United States. Participants completed a demographic questionnaire, the Youth Self‐Report version of the Child Behavior Checklist, and the IMPACT‐III. Disease severity was calculated for Crohn's disease and ulcerative colitis using standardized measures. Results: Greater disease severity, externalizing symptoms, and internalizing symptoms were all independently associated with lower HRQOL. Furthermore, internalizing symptoms partially mediated the relationship between disease activity and HRQOL, reducing the effect of disease severity on HRQOL from 22% to 9% in the mediation model. A Sobel test examining the significance of the indirect effect of disease severity on HRQOL via behavioral dysfunction was marginally nonsignificant (P =.053). Conclusions: Nondisease‐specific variables (e.g., behavioral dysfunction) play an important role in impacting HRQOL. Behavioral dysfunction serves as the mechanism through which disease severity partially impacts HRQOL. Continued research to identify other predictors of HRQOL in pediatric IBD will greatly enhance our future ability to design interventions to improve HRQOL and maximize health outcomes. (Inflamm Bowel Dis 2010;)
DNA sequences required for expression of a Dictyostelium actin gene.

A 2.8‐kb fragment of 5′ non‐coding DNA from the Dictyostelium actin 15 gene has previously been shown to contain all of the cis‐acting DNA sequence elements required for normal developmentally‐regulated transcription of actin gene fusion RNAs when reintroduced into the genome by DNA‐mediated transformation. Deletion analysis of this promoter fragment indicates that all of the necessary information is contained within a 270‐bp fragment of actin 15 5′ non‐coding DNA. This fragment contains four short G/C‐rich repeated sequences that are also found in other co‐regulated Dictyostelium actin genes. A 12‐bp consensus sequence, AAAAATGGGG/ATT, is present in the regions essential for expression of two different Dictyostelium actin genes, actin 6 and actin 15, but is absent from an actin gene showing a different temporal pattern of developmental regulation. Deletion analysis and DNase I footprinting implicate this sequence as a functional cis‐acting element required for transcription of the actin 15 gene.
RELATIONSHIP OF ENERGY EXPENDITURE TO TOTAL EXCHANGEABLE POTASSIUM

The problem of finding relationships between the energy requirements of the intact organism and the various parameters of the body’s shape, size, and composition has intrigued scientists for over a century. Relating basal metabolic expenditure to such an easily measurable index of size as body weight produced poor correlation, and surface area has been thought to be a preferable index for energy expenditure. DuBois’ observed in 1927, “It is doubtful if many physiologists have held the belief that the surface area was the immediate cause of metabolism. ” He went on to point out, however, the practical aspects of this apparent relationship and defend its use on an empiric basis. The development of extensive tables from which surface area could be derived from measured height and weight represented a significant advance in this field. But the use of surface area has remained controversial, and certain workers continue to feel that a fractional power of the total body weight represents a better index for basal energy metabolism than does surface area. This reference standard has been studied in many animal species and, although fairly good correlations have been found when comparing the mean values for different species, in individuals of the same species no single fractional power of the body weight gives a good index of body s i ~ e . ~ , ~ , ~ Rubner5 had introduced the concept of “active tissue mass” and its possible relationship to body heat production at the beginning of this century. Measurement of such an actively metabolizing portion of the body has awaited the development of new approaches to analysis of body composition. If any of the newer techniques could be shown to identify the protoplasmic fraction of the body which is metabolically active, the correlation between ths body fraction and the measurement of energy expenditure based on oxygen consumption and carbon dioxide production should achieve greater physiologic significance than the correlation with surface area, and perhaps would provide a more accurate basis for establishing norms of metabolic expenditure. Many reference standards for body composition have been studied in an effort to define the metabolizing cell mass. Moulted in 1916, reported a correlation between total body nitrogen and the fat-free carcass weights
Part of Speech Tagging for Hindi Corpus

The wide utilization of internet for making search of information has got emerging use of computational linguistics as most of the search systems uses bag of words mode which causes problem in retrieval due to polysemy, homonymy, synonymy[9][3]. This has lead to shift in the accepted boundary between what kinds of query information are submitted by humans and what kinds further intreprations in form of annotation of query information can be done so as to get better results[1][4]. In this regards the process of annotating the words in a text in accordance to a particular part of speech is the objective of this paper. further POS tagging is much tougher than making a list of words and their parts of speech, as most words tend to have more than one part of speech in different scenarios and some parts of speech of these words are rather complex or unspoken[5] [6]. There are large numbers of POS tagger available for english language which has got satisfactory performance but cannot be applied to hindi language due to structural differences[8]. This paper aims at part of speech tagging for hindi corpus as large no of hindi documents are growing on internet.
Inter-brain Synchrony and Eye Gaze Direction During Collaboration in VR

Brain activity sometimes synchronises when people collaborate together on real world tasks. Understanding this process could to lead to improvements in face to face and remote collaboration. In this paper we report on an experiment exploring the relationship between eye gaze and inter-brain synchrony in Virtual Reality (VR). The experiment recruited pairs who were asked to perform finger-tracking exercises in VR with three different gaze conditions: averted, direct, and natural, while their brain activity was recorded. We found that gaze direction has a significant effect on inter-brain synchrony during collaboration for this task in VR. This shows that representing natural gaze could influence inter-brain synchrony in VR, which may have implications for avatar design for social VR. We discuss implications of our research and possible directions for future work.
Multi-Resolution Surface Approximation for Animation

This paper considers the problem of approximating a digitized surface in R3 with a hierarchical bicubic B-spline to produce a manipulatable surface for further modeling or animation. The 3D data''s original mapping from R3 (multiple rows of cylindrical scans) is mapped into the parametric domain of the B-splice (also in R3) using a modified chord-length parameterization. This mapping is used to produce a gridded sampling of the surface, and a modified full multi-grid (FMG) technique is employed to obtain a high-resolution B-spline approximation. The intermediate results of the FMG calculations generate the component overlays of a hierarchical spline surface reconstruction. Storage requirements of the hierarchical representation are reduced by eliminating offsets wherever their removal will not increase the error in the approximation by more than a given amount. The resulting hierarchical spline surface is interactively modifiable (modulo the size of the dataset and computing power) using the editing capabilities of the hierarchical surface representation allowing either local or global changes to surface shape while retaining details of the scanned data.
Clinical outcome following transcatheter aortic valve implantation in patients with impaired left ventricular systolic function

Objectives: To determine the prevalence of impaired left ventricular (LV) systolic function and its impact on the in‐hospital and long‐term outcome in patients who underwent Transcatheter Aortic Valve Implantation (TAVI). Background: Although impaired LV function may be considered a contra‐indication for aortic valve replacement, the hemodynamic characteristics of transcatheter valves may offer procedural and long‐term clinical benefit in such patients. Methods: 230 consecutive patients underwent TAVI with the Medtronic‐CoreValve System. Impaired LV function was defined by a Left Ventricular Ejection Fraction (LVEF) ≤ 35% (European Multicenter Study on Operative Risk Stratification and Long‐term Outcome in patients with Low‐Flow/Low‐Gradient Aortic Stenosis). Study endpoints were selected and defined according to the Valve Academic Research Consortium recommendations. Results: Compared with patients with a LVEF > 35% (n = 197), those with LVEF ≤ 35% (n = 33) were more often male (78.8 % vs. 46.7%, P < 0.001), more symptomatic (NYHA class III or IV, 97.0% vs. 77.2%, P = 0.008) and had a higher prevalence of prior coronary artery disease (63.6% vs. 43.1%, P = 0.029). The Logistic EuroSCORE was 14.8% and 22.8, respectively (P = 0.012). No difference was observed between the two groups in in‐hospital or 30‐day mortality (3.0% vs. 9.6%, P = 0.21), the Combined Safety Endpoint at 30 days (24.2% and 24.4%, P = 0.99) and survival free from readmission at one year (69.2% and 69.7%, P = 0.85). After adjustment, LVEF ≤ 35% was not associated with an increased risk of 30‐day mortality, in‐hospital complications and survival free from readmission at follow‐up. Conclusion: The immediate and long‐term outcome after TAVI did not differ between patients with an impaired and preserved LVEF. LVEF ≤ 35% did not predict adverse immediate and long‐term outcome. These findings suggest that TAVI should not be withheld in selected patients with impaired LV function. © 2011 Wiley Periodicals, Inc.
Calcium-stimulated Autophosphorylation Site of Plant Chimeric Calcium/Calmodulin-dependent Protein Kinase*

The existence of two molecular switches regulating plant chimeric Ca2+/calmodulin-dependent protein kinase (CCaMK), namely the C-terminal visinin-like domain acting as Ca2+-sensitive molecular switch and calmodulin binding domain acting as Ca2+-stimulated autophosphorylation-sensitive molecular switch, has been described (Sathyanarayanan, P. V., Cremo, C. R., and Poovaiah, B. W. (2000) J. Biol. Chem. 275, 30417–30422). Here we report the identification of Ca2+-stimulated autophosphorylation site of CCaMK by matrix-assisted laser desorption ionization time of flight-mass spectrometry. Thr267 was confirmed as the Ca2+-stimulated autophosphorylation site by post-source decay experiments and by site-directed mutagenesis. The purified T267A mutant form of CCaMK did not show Ca2+-stimulated autophosphorylation, autophosphorylation-dependent variable calmodulin affinity, or Ca2+/calmodulin stimulation of kinase activity. Sequence comparison of CCaMK from monocotyledonous plant (lily) and dicotyledonous plant (tobacco) suggests that the autophosphorylation site is conserved. This is the first identification of a phosphorylation site specifically responding to activation by second messenger system (Ca2+ messenger system) in plants. Homology modeling of the kinase and calmodulin binding domain of CCaMK with the crystal structure of calcium/calmodulin-dependent protein kinase 1 suggests that the Ca2+-stimulated autophosphorylation site is located on the surface of the kinase and far from the catalytic site. Analysis of Ca2+-stimulated autophosphorylation with increasing concentration of CCaMK indicates the possibility that the Ca2+-stimulated phosphorylation occurs by an intermolecular mechanism.
Exploitation of stream processing on graphical Processors in Inertial Navigation

This paper focusses on implementing an Inertial Navigation System (INS) on a Graphics Processor Unit (GPU). The GPU allows simultaneous processing of large amounts of data and multiple use of the algorithm at the same time. Using the stream processing abilities of the GPU an investigation is launched into the simultaneous running of several navigation algorithms (INS's) with different sensor error models for each INS algorithm. The simultaneous processing of several INS systems allows for faster simulation times and data analysis. Aiding an error perturbed INS with a Kalman filter (KF) is considered when tuning the KF to obtain the optimally tuned KF from n amounts of KF's.
[Guidelines on bone mineral disorder in chronic kidney disease--addendum chapter 2].

1 – AVALIACAO DOS NIVEIS DE PARATORMONIO (PTH) E FOSFATASE ALCALINA (FA) NA DRC 1.1 – Os niveis sericos de PTH devem ser analisados em todos os pacientes com DRC, cuja taxa de filtracao glomerular (TFG) for inferior a 60 mL/min/1,73 m2 (Evidencia). Deve-se modificar a frequencia de avaliacao dos niveis sericos de PTH se os resultados das analises mostrarem uma tendencia de elevacao ou de descenso ou apos a instituicao do tratamento, seja ele para reduzir ou elevar os [. ]