Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes of Multiple Runs of Extracorporeal Membrane Oxygenation: An analysis of the Extracorporeal Life Support Registry

Objective: When patients deteriorate after decannulation from extracorporeal membrane oxygenation (ECMO), a second run of extracorporeal support may be considered. However, repeat cannulation can be difficult and poor outcomes associated with multiple ECMO runs are a concern. The aim of this study was to evaluate outcomes and identify factors associated with survival and mortality in cases of multiple runs of extracorporeal membrane oxygenation. Design: Retrospective cohort analysis of the Extracorporeal Life Support Organization Registry. Setting: The Extracorporeal Life Support Organization’s registry was queried for neonates, children, and adults receiving 2 or more runs of ECMO during the same hospitalization, for any indication, from 1998 to 2015. Patients: 1,818 patients from the Extracorporeal Life Support Organization Registry. Results: Of the 1,818 patients, 1,648 underwent 2 runs and 170 underwent 3 or more runs of ECMO. The survival to discharge rate was 36.7% for 2 runs and 29.4% for 3 or more runs. No significant differences in survival were detected in analysis by decade of ECMO run (p = 0.21). Pediatric patients had less mortality than adults (OR: 0.45, 95%CI: 0.24-0.82). Cardiac support on the first run portrayed worse mortality than pulmonary support regardless of final run indication (OR:1.38, 95%CI: 1.09-1.75). Across all age groups, patients receiving pulmonary support on the last run tended to have higher survival rates regardless of support type on the first run. The only first run complication independently predictive of mortality on the final run was renal complications (OR: 1.60, 95%CI: 1.28-1.99). Conclusions: Though the use of multiple runs of ECMO is growing, outcomes remain poor for most cohorts. Survival decreases with each additional run. Patients requiring additional runs for a pulmonary indication should be considered prime candidates. Renal complications on the first run significantly increases the risk of mortality on subsequent runs, and as such, careful consideration should be applied in these cases.
Evaluation on curative effects of ethylene diamine tetra-acetic acid chelation therapy in treating with atherosclerotic cardiovascular disease

Abstract Background: Ethylene diamine tetra-acetic acid (EDTA) is a chelating agent which attach to metals such as calcium and enables their elimination. In particular, some researchers suggest chelation with EDTA to treat cardiovascular disease with the hypothesis of moderating calcium to decrease atherosclerotic calcification of arteries. However, chelation with EDTA therapeutic effects in atherosclerotic cardiovascular disease is still unclear. Therefore, we propose to undertake a meta-analysis to assess the curative effects of EDTA chelation therapy in patients with atherosclerotic cardiovascular disease. Methods: In the current study, we set to perform a systematic literature search using the electronic databases of 4 most commonly used English databases (EMBASE, MEDLINE, Cochrane Library, and ClinicalTrials.gov trials register), as well as 3 most commonly employed Chinese databases (China Nation Knowledge Infrastructure, Wan Fang, and VIP), from the date of database inception until September 30, 2020 to identify relevant randomized controlled studies of the evaluation on curative effects of EDTA chelation therapy in patients with atherosclerotic cardiovascular disease. In the study, 2 authors worked independently to screen search results, chose studies for inclusion, then they extracted pertinent data to evaluate and study quality based on Cochrane Risk of Bias Tool V.2. 0. Additionally, we will address discrepancies by consultation with a third author. We also intend to use pooled risk ratio (RR) and pooled mean difference (MD) or pooled standardized mean difference (SMD) with 95% confidence intervals (CI) to approximate the relative strength of curative effects of EDTA chelation therapy in patients with atherosclerotic cardiovascular disease. Results: The results of the current study will systematically assess curative effects of EDTA chelation therapy in patients with atherosclerotic cardiovascular disease. Conclusion: The study will infer the currently published evidence to evaluate curative effects of EDTA chelation therapy in patients with atherosclerotic cardiovascular disease, which might be beneficial to these patients. Ethics and dissemination: The present study is a systematic review, hence the pooled results are founded upon the published evidence. Therefore, ethical approval is not necessary for the study. Open Science Framework Registration Number: October 20, 2020.osf.io/tvmk8. (https://osf.io/tvmk8/).
Childhood Adversities in Narcissistic Personality Disorder in China

The controversy surrounding the diagnostic classification of personality disorder (PD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5; American Psychiatric Association, 2013), has garnered little attention and debate in the Chinese psychiatric field. Few articles published in the Chinese literature have addressed the DSM-5 PD classification, especially for narcissistic personality disorder (NPD), which generally has been overlooked in Chinese clinical practice. NPD is characterized by distinct personality features of exaggerating (in fantasy or behavior), requiring praise, and lacking empathy (Caligor et al., 2015). In the Chinese Classification of Mental Disorders, Third Edition (CCMD-3), published in 2001, NPD was classified as a category of other or unspecified personality disorders. Therefore, the current situation of NPD diagnosis in China results in this category being completely overlooked under the current diagnostic system. However, in our previous clinical survey, we found that occurrence of NPD is not rare in Chinese psychiatric services. Using a structured clinical interview by an independent researcher, but not by their own clinicians, the prevalence rate of NPD in one of the largest psychological counseling agencies in China was found to be 4% (Jiang et al., 2019). Because the diagnostic criteria for NPD originated entirely in Western countries, whether childhood maltreatment leads to the formation of Chinese NPD merits investigation. There were 1,402 outpatients screened at the Shanghai Mental Health Center (SMHC) from an epidemiological study of DSM-IV PDs in China (Zhang, Wang et al., 2012). In the current study, 56 outpatients with NPD were included, and 447 patients without any type of PD were selected as a control group for comparison. The majority of patients with NPD were male (80.4%), and the average age was 32 ±11 years. Among the 447 controls, the proportion of men was 44.3% (n = 198). The average age was 30.1 ±9.1 years. The NPD group compared with the controls without PD had no significant difference in age (t = 0.928, p = .357), but the proportion of men in the NPD group was significantly higher than men in the control group
Reliability of evidence‐review methods in restoration ecology

In restoration science, evidence reviews play a crucial role in summarizing research findings in practice and policy. However, if unreliable or inappropriate methods are used to review evidence, decisions based on these reviews may not accurately reflect the available evidence base. To assess the current value of restoration reviews, we examined a sample of meta‐analyses and narrative syntheses (n = 91) with the Collaboration for Environmental Evidence Synthesis Assessment Tool (CEESAT), which uses detailed criteria to assesses the method of policy‐relevant evidence synthesis according to elements important for objectivity, transparency, and comprehensiveness. Overall, reviews scored low based on this standard: median score 16 out of 39, modal score 15, and mean 16.6. Meta‐analyses scored higher than narrative syntheses (median 17 vs. 5, respectively), although there were some outlier narrative syntheses that had high scores, suggesting that quantitative synthesis does not solely reflect the reliability of a review. In general, criteria spanning the more fundamental review stages (i.e., searching for studies and including studies) received low scores for both synthesis types. Conversely, criteria comprising the later stages of the review (i.e., critical appraisal, data extraction, and data synthesis) were generally well described in meta‐analyses; thus, these criteria achieved the highest individual CEESAT scores. We argue that restoration ecology is well positioned to advance so‐called evidence‐based restoration, but review authors should elucidate their conceptual understanding of evidence syntheses and recognize that conducting reliable reviews demands the same methodological rigor and reporting standards used in primary research. Given the potential of evidence reviews to inform management, policy, and research, it is of vital importance that the overall methodological reliability of restoration reviews be improved.
Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy

Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant epilepsy in adults and is often associated with hippocampal sclerosis. Here, we established the efficacy of optogenetic and electrical low-frequency stimulation (LFS) in interfering with seizure generation in a mouse model of MTLE. Specifically, we applied LFS in the sclerotic hippocampus to study the effects on spontaneous subclinical and evoked generalized seizures. We found that stimulation at 1 Hz for 1 hr resulted in an almost complete suppression of spontaneous seizures in both hippocampi. This seizure-suppressive action during daily stimulation remained stable over several weeks. Furthermore, LFS for 30 min before a pro-convulsive stimulus successfully prevented seizure generalization. Finally, acute slice experiments revealed a reduced efficacy of perforant path transmission onto granule cells upon LFS. Taken together, our results suggest that hippocampal LFS constitutes a promising approach for seizure control in MTLE.
Constitutive activation of Lyn kinase enhances BCR responsiveness, but not the development of CLL in Eµ-TCL1 mice.

The treatment of chronic lymphocytic leukemia (CLL) has been improved dramatically by inhibitors targeting B-cell receptor (BCR)-associated kinases. The tyrosine kinase Lyn is a key modulator of BCR signaling and shows increased expression and activity in CLL. To evaluate the functional relevance of Lyn for CLL, we generated a conditional knockin mouse model harboring a gain-of-function mutation of the Lyn gene (LynY508F), which was specifically expressed in the B-cell lineage (Lynup-B). Kinase activity profiling revealed an enhanced responsiveness to BCR stimulation in Lynup-B B cells. When crossing Lynup-B mice with Eµ-TCL1 mice (TCL1tg/wt), a transgenic mouse model for CLL, the resulting TCL1tg/wt Lynup-B mice showed no significant change of hepatomegaly, splenomegaly, bone marrow infiltration, or overall survival when compared with TCL1tg/wt mice. Our data also suggested that TCL1 expression has partially masked the effect of the Lynup-B mutation, because the BCR response was only slightly increased in TCL1tg/wt Lynup-B compared with TCL1tg/wt. In contrast, TCL1tg/wt Lynup-B were protected at various degrees against spontaneous apoptosis in vitro and upon treatment with kinase inhibitors targeting the BCR. Collectively, and consistent with our previous data in a Lyn-deficient CLL model, these data lend further suggest that an increased activation of Lyn kinase in B cells does not appear to be a major driver of leukemia progression and the level of increased BCR responsiveness induced by Lynup-B is insufficient to induce clear changes to CLL pathogenesis in vivo.
Exploring the Impact of Internet Use on Memory and Attention Processes

The rapid uptake of the internet has provided a new platform for people to engage with almost all aspects of life. As such, it is currently crucial to investigate the relationship between the internet and cognition across contexts and the underlying neurobiological mechanisms driving this. We describe the current understanding of this relationship across the literature and outline the state of knowledge surrounding the potential neurobiological drivers. Through focusing on two key areas of the nascent but growing literature, first the individual- and population-level implications for attention processes and second the neurobiological drivers underpinning internet usage and memory, we describe the implications of the internet for cognition, assess the potential mechanisms linking brain structure to cognition, and elucidate how these influence behaviour. Finally, we identify areas that now require investigation, including (i) the importance of the variation in individual levels of internet usage, (ii) potential individual behavioural implications and emerging population-level effects, and the (iii) interplay between age and the internet–brain relationships across the stages of development.
Prevalence of Depression and Anxiety in Adolescents With Hearing Loss.

OBJECTIVE To develop and implement a universal screening protocol for depression and anxiety in adolescents serviced in an otology and audiology practice and to estimate the prevalence of depression and anxiety in adolescents with hearing loss, while also comparing rates by degree of hearing loss and type of hearing device used. STUDY DESIGN Cross-sectional. SETTING University tertiary medical center. PATIENTS One hundred four adolescents 12- to 18-years-old who attended an otology clinic in a large metropolitan hospital in the southeastern United States. MAIN OUTCOME MEASURE (s): Depression (PHQ-8), anxiety (GAD-7), degree of hearing loss, type of hearing loss, and type of hearing device utilized. RESULTS Twenty-five percent of adolescents scored above the clinical cutoff on at least one of the depression and/or anxiety measures, with 10% scoring in the elevated range on both measures. Specifically, 17% scored above the cutoff on the PHQ-8 and 16% scored in the clinically significant range for the GAD-7. An additional 30 and 21% scored in the at-risk range for depression and anxiety, respectively. Older adolescents were more likely to score within the elevated range for depression (r = 0.232, p = 0.026). Also, adolescents with severe to profound hearing loss had higher rates of depression and anxiety. CONCLUSIONS Integration of mental health screening is needed in otology and audiology practices both to identify those who require psychological support and to provide appropriate treatment to reduce long-term impact of hearing loss on quality of life and mental health functioning in adolescents.
Precise measurement of chlorine stable isotopic ratios by thermal ionization mass spectrometry

An improved method for chlorine isotopic analysis by thermal ionization mass spectrometry of Cs2Cl+ has been investigated for precise measurement of 37Cl/35Cl isotopic ratios for small amount of samples. Chlorine in organic and inorganic samples was recovered as AgCl and converted to CsCl with metallic Mg and Cs-form ion exchange resin. The CsCl (containing 2 μg of Cl) was loaded on a Ta filament together with graphite powder. The 37Cl/35Cl ratio measurement was carried out using Cs2Cl+ ions with multi Faraday cup (static mode) for 80–100 min each single run. Replicate analysis of ocean water and laboratory standard (CsCl reagent) yield the in-run precision of 0.1–0.2‰ (2σm) for 300–400 ratios and external precision of 0.1–0.2‰ (1σSD). This method has been tested on a variety of chemical reagents including metal chlorides, hydrochloric acid and chlorinated organic solvents. It was found that the artificial chlorine compound show large variations of 37Cl/35Cl ratio (total ranges from −5 to +3‰ relative to standard mean ocean chloride) depending upon manufacturing processes. We suggest that the high sensitivity and precision technique established in this work would allow us to detect small isotopic variations of chlorine in small amounts of natural samples such as terrestrial materials (minerals/rocks, sediments, groundwater, etc, as well as environmental materials), meteorites and other planetary materials.
The spin‐forbidden a 4Π(ν=13–15) and b 4Σ−(ν=3)←X 2Π(ν=0) bands of nitric oxide: A new scheme for quantum state‐specific high‐resolution kinetic energy measurements

A new scheme for performing high‐resolution kinetic energy measurements on single quantum states of NO is described. Laser excitation of the a 4Π(ν=13–15) and b 4Σ−(ν=3)←X 2Π(ν=0) spin‐forbidden bands has been used to produce NO a 4Π, either by direct excitation or after excitation to NO b 4Σ− followed by b→a emission. The sensitivity is compared to previous experiments on CO, employing the forbidden Cameron system. In the course of these experiments, three previously unknown vibronic levels of the a 4Π state were observed for which high precision molecular constants have been obtained. The derived molecular constants have been used to construct a chemically accurate RKR potential for the a 4Π state to within 0.2 eV of the dissociation limit. In addition, the electric dipole moments for the a 4Π(ν=13–14) levels have been determined. By comparing the experimental results with two ab initio calculations, the polarity of the dipole moment of the a 4Π state at equilibrium separation could be determined. A set.
Long-Term Cd Exposure Alters the Metabolite Profile in Stem Tissue of Medicago sativa

As a common pollutant, cadmium (Cd) is one of the most toxic heavy metals accumulating in agricultural soils through anthropogenic activities. The uptake of Cd by plants is the main entry route into the human food chain, whilst in plants it elicits oxidative stress by unbalancing the cellular redox status. Medicago sativa was subjected to chronic Cd stress for five months. Targeted and untargeted metabolic analyses were performed. Long-term Cd exposure altered the amino acid composition with levels of asparagine, histidine and proline decreasing in stems but increasing in leaves. This suggests tissue-specific metabolic stress responses, which are often not considered in environmental studies focused on leaves. In stem tissue, profiles of secondary metabolites were clearly separated between control and Cd-exposed plants. Fifty-one secondary metabolites were identified that changed significantly upon Cd exposure, of which the majority are (iso)flavonoid conjugates. Cadmium exposure stimulated the phenylpropanoid pathway that led to the accumulation of secondary metabolites in stems rather than cell wall lignification. Those metabolites are antioxidants mitigating oxidative stress and preventing cellular damage. By an adequate adjustment of its metabolic composition, M. sativa reaches a new steady state, which enables the plant to acclimate under chronic Cd stress.
Spatially Filtered Emotional Faces Dominate during Binocular Rivalry

The present investigation explores the role of bottom-up and top-down factors in the recognition of emotional facial expressions during binocular rivalry. We manipulated spatial frequencies (SF) and emotive features and asked subjects to indicate whether the emotional or the neutral expression was dominant during binocular rivalry. Controlling the bottom-up saliency with a computational model, physically comparable happy and fearful faces were presented dichoptically with neutral faces. The results showed the dominance of emotional faces over neutral ones. In particular, happy faces were reported more frequently as the first dominant percept even in the presence of coarse information (at a low SF level: 2–6 cycle/degree). Following current theories of emotion processing, the results provide further support for the influence of positive compared to negative meaning on binocular rivalry and, for the first time, showed that individuals perceive the affective quality of happiness even in the absence of details in the visual display. Furthermore, our findings represent an advance in knowledge regarding the association between the high- and low-level mechanisms behind binocular rivalry.
Interrater and Intrarater Reliability of Cranial Anthropometric Measurements in Infants with Positional Plagiocephaly

(1) Background: anthropometric measurements with calipers are used to objectify cranial asymmetry in positional plagiocephaly but there is controversy regarding the reliability of different methodologies. Purpose: to analyze the interrater and intrarater reliability of direct anthropometric measurements with caliper on defined craniofacial references in infants with positional plagiocephaly. (2) Methods: 62 subjects (<28 weeks), with a difference of at least 5 mm between cranial diagonal diameters. Maximal cranial circumference, length and width and diagonal cranial diameters were measured. Intrarater (2 measurements) and interrater (2 raters) reliability was analyzed. (3) Results: intra- and interrater reliability of the maximal cranial length and width and right cranial diagonal was excellent: intraclass correlation coefficient (ICC) > 0.9. Intrarater and interrater reliability for the left cranial diagonal was excellent: ICC > 0.9 and difference in agreement in the Bland-Altman plot 0.0 mm, respectively. Intrarater and interrater reliability for the maximal cranial circumference was good: differences in agreement in Bland-Altman plots: intra: −0.03 cm; inter: −0.12 cm. (4) Conclusions: anthropometric measurements in a sample of infants with moderate positional plagiocephaly have shown excellent intra- and interrater reliability for maximal cranial length, maximal cranial width, and right and left cranial diagonals, and good intra- and interrater reliability in maximal cranial circumference measurement.
Annual Review of Heat Transfer

The volumes of Annual Review of Heat Transfer published up to 2005 were edited by Professor Chang-Lin Tien. Chang-Lin had a long-lasting impact on the heat transfer community through his pioneering research. The current editors decided to use Volume XIV as a bridge between the past and the future by summarizing Chang-Lin's contributions and reviewing current and future research directions in areas in which Professor Tien made a significant impact. In this volume, his contributions are divided into six topical areas: radiation and combustion, micro/nanoscale heat transfer, phase change and heat pipes, porous media, materials processing and laser materials interactions, and energy systems. Previous volumes of Annual Review in Heat Transfer all aspects of heat transfer and fluid flow are examined by an array of the top international specialists in the field. Future volumes are being planned to include contemporary achievements in the thermal and fluids sciences.