Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular events in patients treated with chimeric antigen receptor T-cell therapy for aggressive B-cell lymphoma

Standard of care (SOC) chimeric antigen receptor (CAR) T-cell therapies such as axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are associated with multisystem toxicities. There is limited information available about cardiovascular (CV) events associated with SOC axi-cel or tisa-cel. Patients with CV comorbidities, organ dysfunction, or lower performance status were often excluded in the clinical trials leading to their Food and Drug Adminsitration approval. An improved understanding of CV toxicities in the real-world setting will better inform therapy selection and management of patients receiving these cellular therapies. Here, we retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B-cell lymphoma treated with SOC axi-cel or tisa-cel. Among the 165 patients evaluated, 27 (16%) developed at least one 30-day (30-d) major adverse CV event (MACE). Cumulatively, these patients experienced 21 arrhythmias, four exacerbations of heart failure/cardiomyopathy, four cerebrovascular accidents, three myocardial infarctions, and one patient died due to myocardial infaction. Factors significantly associated with an increased risk of 30-d MACE included age ≥60 years, an earlier start of cytokine release syndrome (CRS), CRS ≥ grade 3, long duration of CRS, and use of tocilizumab. After a median follow-up time of 16.2 months (range, 14.3-19.1), the occurrence of 30-d MACE was not significantly associated with progression-free survival or with overall survival. Our results suggest that the occurrence of 30-d MACE is more frequent among patients who are elderly, with early, severe, and prolonged CRS. However, with limited follow-up, larger prospective studies are needed, and multidisciplinary management of these patients is recommended.
RISK-BASED BRIDGE MANAGEMENT.

This paper outlines a methodology for bridge project selection based on reliability methods and optimization procedures, which could serve as part of a bridge management system. The Markovian model is used to decay the structural components. Then, a reliability index is determined for each element using either subjective assessment or first-order reliability methods. The overall reliability of the bridge is calculated as a system reliability by combining the individual reliability of the components in a series system. Risk is obtained from the reliability of the bridge and the consequence of closure. Repairs can be modeled in any year. The optimum set of repairs is defined as that which minimizes the total network risk in the planning horizon. Methods for finding the optimum set of repairs are discussed, and a near-optimum algorithm is selected.
Optimization of a Supercharged Single Cylinder Engine for a Formula SAE Racing Car

The paper reviews the development and optimization of a SI high performance engine, to be used in Formula SAE/Student competitions. The base engine is a single cylinder Yamaha 660cc motorcycle unit, rated at about 48 HP at 6000rpm. Besides the reduction of engine capacity to 600cc and the mounting of the required restrictor, mechanical supercharging has been adopted in order to boost performance. The fluid-dynamic optimization of the engine system has been performed by means of 1D-CFD simulation, coupled to a single-objective genetic algorithm, developed by the authors. The optimization results have been compared to the ones obtained by a well known commercial optimization software, finding a good agreement. Experiments at the brake dynamometer have been carried out, in order to support engine modeling and to demonstrate the reliability of the optimization process.
2.4.2 Incorporating Software Cost and Risk Assessment into Early System Development Trade Studies

This paper introduces a new method called SOCRATES (Software Cost and Risk Assessment for Trade and Engineering Studies) for incorporating software cost and risk assessment into the early concept development activities and trade studies typically conducted for complex systems. Early conceptual architecture trade studies often omit software cost and risk in architectural comparisons. However, the increasing importance of software in complex system design and its impact on project risk necessitates consideration of the cost and risk associated with developing and fielding software in early engineering architectural trade studies. SOCRATES takes into consideration the allocation of functionality to both software and human controllers and evaluates the utility of assigning control based on development cost, development risk, and mission risk. It also provides input to system engineers about the relative comparison of the cost and risk for a variety of system architecture concepts as well as recommendations based on the results. The technique is demonstrated on the Lunar and Mars Transportation and Surface Operations Architectures developed for the NASA Exploration Initiative Concept Exploration and Refinement Study.
Antigenic Distance between North American Swine and Human Seasonal H3N2 Influenza A Viruses as an Indication of Zoonotic Risk to Humans

Human H3N2 influenza A viruses spread to pigs in North America in the 1990s and more recently in the 2010s. These cross-species events led to sustained circulation and increased H3N2 diversity in pig populations. ABSTRACT Human-to-swine transmission of influenza A virus (IAV) repeatedly occurs, leading to sustained transmission and increased diversity in swine; human seasonal H3N2 introductions occurred in the 1990s and 2010s and were maintained in North American swine. Swine H3N2 strains were subsequently associated with zoonotic infections, highlighting the need to understand the risk of endemic swine IAV to humans. We quantified antigenic distances between swine H3N2 and human seasonal vaccine strains from 1973 to 2014 using a panel of monovalent antisera raised in pigs in hemagglutination inhibition (HI) assays. Swine H3N2 lineages retained the closest antigenic similarity to human vaccine strains from the decade of incursion. Swine lineages from the 1990s were antigenically more similar to human vaccine strains of the mid-1990s but had substantial distance from recent human vaccine strains. In contrast, lineages from the 2010s were closer to human vaccine strains from 2011 and 2014 and the most antigenically distant from human vaccine strains prior to 2007. HI assays using ferret antisera demonstrated that swine lineages from the 1990s and 2010s had significant fold reductions compared to the homologous HI titer of the nearest pandemic preparedness candidate vaccine virus (CVV) or seasonal vaccine strain. The assessment of postinfection and postvaccination human serum cohorts demonstrated limited cross-reactivity to swine H3N2 from the 1990s, especially in older adults born before the 1970s. We identified swine strains to which humans are likely to lack population immunity or are not protected against by a current human seasonal vaccine or CVV to use in prioritizing future human CVV strain selection. IMPORTANCE Human H3N2 influenza A viruses spread to pigs in North America in the 1990s and more recently in the 2010s. These cross-species events led to sustained circulation and increased H3N2 diversity in pig populations. The evolution of H3N2 in swine led to a reduced similarity to human seasonal H3N2 and the vaccine strains used to protect human populations. We quantified the antigenic phenotypes and found that North American swine H3N2 lineages retained more antigenic similarity to historical human vaccine strains from the decade of incursion but had substantial differences compared to recent human vaccine strains. Additionally, pandemic preparedness vaccine strains demonstrated a loss of similarity to contemporary swine strains. Finally, human sera revealed that although these adults had antibodies against human H3N2 strains, many had limited immunity to swine H3N2, especially older adults born before 1970. Antigenic assessment of swine H3N2 provides critical information for pandemic preparedness and candidate vaccine development.
Functional Reconstitution of Dopamine D2 Receptor into a Supported Model Membrane in a Nanometric Confinement.

Dopamine D2 receptor (D2R), a G-protein-coupled receptor (GPCR), plays critical roles in neural functions and represents the target for a wide variety of drugs used to treat neurological diseases. However, its fundamental physicochemical properties, such as dimerization and affinity to different lipid environments, remain unknown. Here, reconstitution and characterization of D2R in a supported model membrane in nanometric confinement are reported. D2R is expressed in Chinese hamster ovary (CHO) cells and transferred into the supported model membrane as cell membrane blebs. D2R molecules are reconstituted with an elevated density in the cleft between the substrate and poly(dimethylsiloxane) (PDMS) elastomer. Reconstituted D2R retains the physiological functions, as evaluated from its binding to an antagonist and dimerization lifetime. The transient dimer formation of D2R, similar to the live cell, suggests that it is an innate property that does not depend on the cellular structures such as actin filaments. Although the mechanism of this unique reconstitution process is currently not fully understood, the finding points to a new possibility of using a nanometric space (<100 nm thick) as a platform for reconstituting and studying membrane proteins under the quasi-physiological conditions, which are difficult to be created by other methods.
Anisotropic thermal conductivity and corrugated patterns in single-layer black phosphorus nanoribbon subjected to shear loading: a molecular dynamics study

Single-layer black phosphorus (SLBP) also known as phosphorene is a recently introduced two-dimensional material with unique structure and promising physical properties that has drawn considerable attention in the field of nanodevices. This structure demonstrates a high anisotropy in mechanical and thermal behavior along zigzag (ZZ) and armchair (AC) principal in-plane directions. Here in this study, it is shown that implementing shear strain on 10 nm × 50 nm SLBP nanoribbons (SLBPNRs) along ZZ and AC directions, the anisotropy leads to different corrugated patterns on the pristine structure. Applying non-equilibrium molecular dynamics under a parameterized Stillinger–Weber potential for modelling SLBP, thermal conductivity (TC) behavior of the sheared SLBPNRs with corrugated patterns are examined. The results show a higher amplitude and wavelength of the corregations on the ZZ-aligned SLBPNRs, which is around two times higher than that of AC-aligned counterparts. Although, it is also shown that unlike some other 2D materials, such as graphene, the wrinkling does not have such a significant effect on TC of SLBP. The phonon density of states results obtained in this work as well as phonon dispersion curves by first-principle calculations in other works concrete this finding. The results show small frequency shifts in both high- and low-frequency phonons, which are not strong enough to affect TC in SLBPNRs. This interesting thermal property of SLBP under shear strain suggests the great potential application of these corrugated structures in nanodevices without any loss of TC abilities.
A General Equivalent Circuit Model for Piezoelectric Generators

This article presents an equivalent circuit model for a piezoelectric generator which can include any number of vibrational modes. First the electromechanical equations are formulated using an assumed mode (for example, the Rayleigh-Ritz method), the mechanical equations are then decoupled by the standard eigenvector approach. A set of single degree of freedom equations are thus produced. The electromechanical coupling terms are modeled in the equivalent circuit using an ideal transformer, or a set of current-and voltage-dependent sources. To validate the equivalent circuit model, the results show excellent agreement with published analytical solutions for the first three vibration modes of a cantilever unimorph generator. The main advantage of the new method is that it can be used to simulate any circuit topology, for which there is no analytical solution, using a standard electronic simulation program. To demonstrate this, the analysis and design of a more complicated diode bridge circuit is presented.
Initial Derivation of a Predictive Model for Left Ventricular Longitudinal Strain (LS) in Early Sepsis

Septic shock is a common deadly disease often associated with cardiovascular dysfunction. Left ventricular longitudinal strain (LV LS) has been proposed as a sensitive marker to measure cardiovascular function; however, it is not available universally in standard clinical echocardiograms. We sought to derive a predictive model for LV LS, using machine learning techniques with the hope that we may uncover surrogates for LV LS. We found that left ventricular ejection fraction, tricuspid annular plane systolic excursion, sepsis source, height, mitral valve Tei index, LV systolic dimension, aortic valve ejection time, and peak acceleration rate were all predictive of LV LS in this initial exploratory model. Future modeling work may uncover combinations of these variables which may be powerful surrogates for LV LS and cardiovascular function.
Early post-septal myectomy outcomes for hypertrophic obstructive cardiomyopathy

Background We aimed to evaluate early outcomes of septal myectomy in patients with hypertrophic cardiomyopathy. Methods We retrospectively analyzed data collected over a 9-year period from 583 patients who underwent septal myectomy for hypertrophic cardiomyopathy at our institution. Results The mean age was 55.7 ± 13.1 years, and 338 (58%) patients were in New York Heart Association class III or IV. There were 11 (1.9%) early deaths, including 3 (0.5%) intraoperative deaths. Early mortality was lowest after isolated septal myectomy (0.8%) and highest after concomitant mitral valve replacement (6.1%). There were 4 (0.7%) and 9 (1.5%) patients with left ventricular wall rupture and ventricular septal defect, respectively, after myectomy. New pacemaker implantation caused by atrioventricular disturbances was required in 29 (5.0%) patients, and was associated with previous alcohol septal ablation (odds ratio 3.34, 95% confidence interval 1.02–11.0, P = 0.047). Left ventricular wall rupture, intraoperative residual (15.5% moderate, 0.3% severe) mitral regurgitation, and pre-discharge residual outflow tract gradient >30 mm Hg (4.6%) occurrences were surgeon-dependent. Conclusions The early results are consistent with example targets reported in the 2020 American College of Cardiology/American Heart Association guidelines for septal reduction therapy outcomes. Septal myectomy safety and efficacy are surgeon-dependent. Previous alcohol septal ablation increases the risk of permanent pacemaker implantation due to postoperative complete atrioventricular block. Therefore, continuous education, mentoring, and learning by doing may play an important role in achieving reasonable septal myectomy safety and efficacy.
Characterizing Tissue Remodeling and Mechanical Heterogeneity in Cerebral Aneurysms

Accurately assessing the complex tissue mechanics of cerebral aneurysms (CAs) is critical for elucidating how CAs grow and whether that growth will lead to rupture. The factors that have been implicated in CA progression – blood flow dynamics, immune infiltration, and extracellular matrix remodeling – all occur heterogeneously throughout the CA. Thus, it stands to reason that the mechanical properties of CAs are also spatially heterogeneous. Here, we present a new method for characterizing the mechanical heterogeneity of human CAs using generalized anisotropic inverse mechanics, which uses biaxial stretching experiments and inverse analyses to determine the local Kelvin moduli and principal alignments within the tissue. Using this approach, we find that there is significant mechanical heterogeneity within a single acquired human CA. These results were confirmed using second harmonic generation imaging of the CA’s fiber architecture and a correlation was observed. This approach provides a single-step method for determining the complex heterogeneous mechanics of CAs, which has important implications for future identification of metrics that can improve accuracy in prediction risk of rupture.
Seismic Damageability Assessment of R/C Buildings in Eastern U.S.

In the eastern United States, reinforced concrete building structures, medium- to high-rise construction, are usually designed for gravity loads only. A damage evaluation was done in this study for typical structures of medium height using inelastic dynamic analysis and artificially simulated earthquake motion. An empirical relation was developed to provide quick assessment for the expected damage in medium-high, reinforced concrete structures. The paper presents the methodology used for this evaluation, including the simulation of artificial ground motion from eastern United States data, and describes the major factors influencing damageability.
Effects of gratitude intervention on mental health and well‐being among workers: A systematic review

Gratitude intervention, which requires participants to engage regularly in brief activities designed to cultivate a sense of gratefulness, is known as one of the most effective positive psychological interventions. Although numerous meta‐analyses and systematic reviews have been conducted on gratitude intervention, no studies have focused on the working population. This study aimed to systematically summarize the effectiveness of gratitude interventions on workers' mental health and well‐being.
The effect of subliminal incentives on goal-directed eye movements

Over the last decades, several studies have demonstrated that conscious and unconscious reward incentives both affect performance in physical and cognitive tasks, suggesting that goal-pursuit can arise from an unconscious will. Whether the planning of goal-directed saccadic eye movements during an effortful task can also be affected by subliminal reward cues has not been systematically investigated. We employed a novel task where participants made several eye movements back and forth between a fixation point and a number of peripheral targets. The total number of targets visited by the eyes in a fixed amount of time determined participants' monetary gain. The magnitude of the reward at stake was briefly shown at the beginning of each trial and masked by pattern images superimposed in time so that at shorter display durations participants perceived reward incentives subliminally. We found a main effect of reward across all display durations as higher reward enhanced participants' oculomotor effort measured as the frequency and peak velocity of saccades. This effect was strongest for consciously perceived rewards but also occurred when rewards were subliminally perceived. Although we did not find a statistically significant dissociation between the reward-related modulation of different saccadic parameters, across two experiments the most robust effect of subliminal rewards was observed for the modulation of the saccadic frequency but not the peak velocity. These results suggest that multiple indices of oculomotor effort can be incentivized by subliminal rewards and that saccadic frequency may provide the most sensitive indicator of subliminal incentivization of eye movements.
A Pilot Study Assessing Reactions to Educational Videos on Harm of Waterpipe among Young Adults Susceptible to Waterpipe Tobacco Smoking

Young adults who never engaged in waterpipe tobacco smoking (WTS) yet are open to trying it, that is, are susceptible, is a high-risk group for initiation WTS. Very few interventions dissuade this group from WTS. Thus, we explored how four short videos that varied themes of WTS harms influenced susceptible young adults’ risk perceptions, risk beliefs, and susceptibility to future WTS. As part of online cross-sectional study, 208 participants aged 18–34 were randomized to watch or not a short video; each video focused on different themes of WTS risks: physical harms, myths about WTS, addiction, and harms to others. The main outcomes were perceived personal risks, risk beliefs, perceived harm of WTS compared to cigarettes, and susceptibility to future WTS. Watching any video increased beliefs of harm of WTS and lowered susceptibility to future WTS compared to not watching a video. The theme of physical harms was most effective at increasing risk beliefs and lowering susceptibility to future WTS. All four videos were rated as credible, engaging, personally relevant, producing negative affect toward WTS, and effective at dissuading WTS. These promising findings suggest further testing is needed to determine if effects persist and prevent WTS among adults susceptible to WTS.
Machine Learning Applications in Mental Health and Substance Use Research Among the LGBTQ2S+ Population: Scoping Review

Background A high risk of mental health or substance addiction issues among sexual and gender minority populations may have more nuanced characteristics that may not be easily discovered by traditional statistical methods. Objective This review aims to identify literature studies that used machine learning (ML) to investigate mental health or substance use concerns among the lesbian, gay, bisexual, transgender, queer or questioning, and two-spirit (LGBTQ2S+) population and direct future research in this field. Methods The MEDLINE, Embase, PubMed, CINAHL Plus, PsycINFO, IEEE Xplore, and Summon databases were searched from November to December 2020. We included original studies that used ML to explore mental health or substance use among the LGBTQ2S+ population and excluded studies of genomics and pharmacokinetics. Two independent reviewers reviewed all papers and extracted data on general study findings, model development, and discussion of the study findings. Results We included 11 studies in this review, of which 81% (9/11) were on mental health and 18% (2/11) were on substance use concerns. All studies were published within the last 2 years, and most were conducted in the United States. Among mutually nonexclusive population categories, sexual minority men were the most commonly studied subgroup (5/11, 45%), whereas sexual minority women were studied the least (2/11, 18%). Studies were categorized into 3 major domains: web content analysis (6/11, 54%), prediction modeling (4/11, 36%), and imaging studies (1/11, 9%). Conclusions ML is a promising tool for capturing and analyzing hidden data on mental health and substance use concerns among the LGBTQ2S+ population. In addition to conducting more research on sexual minority women, different mental health and substance use problems, as well as outcomes and future research should explore newer environments, data sources, and intersections with various social determinants of health.