Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between functional disability and health-related quality of life in patients with a rotator cuff tear

Purpose:To determine the relationship between functional disability and health-related quality of life (HRQoL) in rotator cuff tear (RCT) patients. Method:In 67 RCT patients (mean age, 54 years; 57% males), functional disability was self-reported with the American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES), HRQoL with the Short-Form 36 Health Survey (SF-36), and pain by visual analogue scale. ASES results were divided into tertiles (12–38, 39–51, and 52–82). Results:Mean ASES score was 48 (range, 12–82). Patients with the highest functional disability and highest pain level had the lowest HRQoL. For the highest, middle, and lowest ASES categories, respectively, mean SF-36 Physical Component Summary (PCS) scores were 35 SD 5, 36 SD 8, and 41 SD 6 (p< 0.001) (r = 0.47 for ASES vs. PCS; p< 0.001), and Mental Component Summary (MCS) scores were 50 SD 13, 56 SD 10, and 58 SD 8 (p = 0.011) (r = 0.37 for ASES vs. MCS; p= 0.003). Conclusions: Patients with higher functional disability had lower HRQoL. RCT extensively affects patients’ lives; therefore, capturing both generic and shoulder-specific measures of RCT problems is recommended. Implications for Rehabilitation Rotator cuff tears (RCTs) result from injury or degeneration, and tear prevalence increases with age. RCT causes disabling pain, decline in muscle strength and shoulder mobility. RCT patients with decreased functioning have impaired quality of life.
Texas Medication Algorithm Project: development and feasibility testing of a treatment algorithm for patients with bipolar disorder.

BACKGROUND Use of treatment guidelines for treatment of major psychiatric illnesses has increased in recent years. The Texas Medication Algorithm Project (TMAP) was developed to study the feasibility and process of developing and implementing guidelines for bipolar disorder, major depressive disorder, and schizophrenia in the public mental health system of Texas. This article describes the consensus process used to develop the first set of TMAP algorithms for the Bipolar Disorder Module (Phase 1) and the trial testing the feasibility of their implementation in inpatient and outpatient psychiatric settings across Texas (Phase 2). METHOD The feasibility trial answered core questions regarding implementation of treatment guidelines for bipolar disorder. A total of 69 patients were treated with the original algorithms for bipolar disorder developed in Phase 1 of TMAP. RESULTS Results support that physicians accepted the guidelines, followed recommendations to see patients at certain intervals, and utilized sequenced treatment steps differentially over the course of treatment. While improvements in clinical symptoms (24-item Brief Psychiatric Rating Scale) were observed over the course of enrollment in the trial, these conclusions are limited by the fact that physician volunteers were utilized for both treatment and ratings. and there was no control group. CONCLUSION Results from Phases 1 and 2 indicate that it is possible to develop and implement a treatment guideline for patients with a history of mania in public mental health clinics in Texas. TMAP Phase 3, a recently completed larger and controlled trial assessing the clinical and economic impact of treatment guidelines and patient and family education in the public mental health system of Texas, improves upon this methodology.
Reward and Penalty Functions in Automated Negotiation

Automated negotiation is very important for organizing decentralized systems such as e‐business, p2p systems, cloud computing, and so on. During the course of a negotiation, reward and penalty can be used to increase the chance of reaching agreements between negotiating agents, but have not been applied into automated negotiation systems well, especially integrating both in a single negotiation system. Thus, in this work we make an effort to reveal how the reward increases the acceptability of an offer and how the penalty decreases the deniability of an offer. More specifically, our study shows that the degree, to which a reward and a penalty influence the outcome, depends on the greedy degree for the reward and the creditable degree on the penalty. Therefore, if we know an offeree's utilities of accepting and denying an offer, the greedy degree for reward and the creditable degree on penalty, we can calculate how much reward and penalty the offerer agent needs to change the offeree's mind (i.e., from denying to accepting).
Iron & Steel Enterprise Index Analysis System Based on Data Warehouse

Modern enterprise manages indexes more refined and systematically. This paper reviews common construction and function of data warehouse on huge Iron & Steel enterprise and gives an example of Enterprise's index. This example explains the process of building subject data set and computing and analyzing indexes by models and methods in data warehouse platform. It is proved that using the results of the analysis by multi-way display, the enterprise's requirement can be met, and it can improve efficiency of production.
Detailed examination of Mg 2 + and pH sensitivity of human TRPM 7 1 channels

24 TRPM7 channel-kinase is a protein highly expressed in cells of hematopoietic lineage, 25 such as lymphocytes. Studies performed in native and heterologous expression 26 systems have shown that TRPM7 forms non-selective cation channels functional in the 27 plasma membrane and activated upon depletion of cellular Mg. In addition to internal 28 Mg, cytosolic pH and the phospholipid PI(4,5)P2 are potent physiological regulators of 29 this channel: protons inhibit, while PI(4,5)P2 is required for TRPM7 channel activity. 30 These channels are also inhibited from inside by other metal cations and polyamines. 31 While the regulation of TRPM7 channels by internal metal ions, acidic pH and PI(4,5)P2 32 is voltage-independent, extracellular metal cations and polyamines block voltage33 dependently at micromolar concentrations and appear to occupy a distinct blocking site. 34 In the current study we investigated Mgiand pHi-dependence of native TRPM7 35 currents using whole-cell patch clamp electrophysiology in human Jurkat T lymphocytes 36 and HEK293 cells. 37 Our main findings are: 1) Mg inhibition involves not one but two separate sites 38 of high (~10 μM) and low (~165 μM) affinity; 2) while sharing certain characteristics with 39 Mg inhibition, protons most likely inhibit through one inhibitory site, corresponding to 40 the low affinity Mg site, with an estimated IC50 of pH 6.3. Additionally, we present data 41 on amplitude distribution of pre-activated TRPM7 currents in Jurkat T lymphocytes in 42 the absence of prior Mg or proton depletion. 43
Radiation Response of Cells during Altered Protein Thiol Redox

Abstract Biaglow, J. E. , Ayene, I. S. , Koch, C. J., Donahue, J., Stamato, T. D. , Mieyal, J. J. and Tuttle, S. W. Radiation Response of Cells during Altered Protein Thiol Redox. Radiat. Res. 159, 484–494 (2003). The major focus of this work was to investigate how altered protein thiol redox homeostasis affects radiation-induced cell death. We used the cells of wild-type CHO cell line K1, the CHO cell line E89, which is null for G6PD activity, and a radiation-sensitive CHO cell line, XRS5. The protein-thiol redox status of cells was altered with cell-permeable disulfides, hydroxyethyldisulfide (HEDS) or lipoate. HEDS is primarily reduced by thioltransferase (glutaredoxin), with GSH as the electron donor. In contrast, lipoate is reduced by thioredoxin reductase. HEDS was reduced at a greater rate than lipoate by G6PD-containing K1 (wild-type) cells. Reduction of disulfides by G6PD-deficient cells was significantly slower with HEDS as substrate and was nearly absent with lipoate. The rate of reduction of HEDS by E89 cells decelerated to near zero by 30 min, whereas the reduction continued at nearly the same rate during the entire measurement period for K1 cells. HEDS treatment decreased the GSH and protein thiol (PSH) content more in G6PD-deficient cells than in G6PD-containing cells. On the other hand, lipoate did not significantly alter the protein thiol, but it increased the GSH in K1 cells. Acute depletion of GSH by l-buthionine-sulfoximine (l-BSO) in combination with dimethylfumarate significantly decreased the rate of reduction of HEDS by K1 cells close to that of G6PD-deficient cells. Prior GSH depletion by l-BSO alone significantly decreased the PSH in glucose-depleted E89 cells exposed to HEDS, but this did not occur with K1 cells. The radiation response of G6PD-deficient cells was significantly sensitized by HEDS, but HEDS did not have this effect on K1 cells. The DNA repair-deficient XRS5 CHO cells displayed the same capacity as K1 cells for HEDS reduction, and like K1 cells the XRS5 cells were not sensitized to radiation by HEDS treatment. Deprivation of glucose, which provides the substrate for G6PD in the oxidative pentose phosphate cycle, decreased the rate of bioreduction of HEDS and lipoate in G6PD-containing cells to the level in G6PD-deficient cells. In the absence of glucose, HEDS treatment diminished non-protein thiol and protein thiol to the same level as those in G6PD-deficient cells and sensitized the K1 cells to HEDS treatment. However, depletion of glucose did not alter the sensitivity of XRS5 cells in either the presence or absence of HEDS. Overall the results suggest a major role for pentose cycle control of protein redox state coupled to the activities of the thioltransferase and thioredoxin systems. The results also show that protein thiol status is a critical factor in cell survival after irradiation.
A novel virtual experimentation approach to planning and training for manufacturing processes--the virtual machine shop

This paper discusses the use of a virtual experimentation environment as a planning and training tool for machining processes. This approach involves the virtual performance of machining processes within a Virtual Machine Shop environment. The features of this environment enable the user to set up a process, to operate a machine tool, to edit and execute an NC part program in an immersive and interactive way. Additional functions are provided in order to support process verification in terms of geometrical, technical and economic characteristics. A test case is presented in order to demonstrate the simulation functions of the Virtual Machine Shop and the capability of the system to deal with machining planning and training problems.
(E)-4-Methoxy-N′-[(pyridin-4-yl)methylidene]benzohydrazide monohydrate

In the title compound, C14H13N3O2·H2O, the azomethine double bond adopts an E conformation and the N—N=C—C torsion angle is 178.37 (19)°. The dihedral angle between the benzene and pyridine rings is 5.58 (12)° and the C atom of the methoxy group is roughly coplanar with its attached ring [deviation = 0.157 (3) Å]. In the crystal, the components are linked by O—H⋯O, O—H⋯N, N—H⋯O and C—H⋯O hydrogen bonds, forming (001) sheets. The water O atom accepts one N—H⋯O and two C—H⋯O interactions from the adjacent organic molecule.
Correcting for misinformation using machine learning ∗

We propose several algorithms to reduce errors of classification created by using imperfect training sets. A classic example is misallocation of scarce funds to poor households due to unobserved income in combination with data misreporting or corruption at the administrative level. Suppose there are several training examples in which the targets are misclassified at a certain rate. Since the errors are imperfectly correlated across training examples, wrongly classified observations in one sample will share common characteristics with observations that are differently classified in other samples. We use this insight to develop several machine learning algorithms to reduce this classification error. We apply the algorithms to the context of aid programs targeting poor households with limited knowledge of their true income and poverty ranking. In our mainline specification of the problem, our main algorithm makes a 37% improvement in the allocation of the funds. ∗This paper is an extended version of a project developed in a machine learning course at Stanford. †Department of Economics, Stanford University, 579 Serra Mall, Stanford, CA 94305, adugalic@stanford.edu. ‡Department of Economics, Stanford University, 579 Serra Mall, Stanford, CA 94305, tram@stanford.edu 1
Proteomic identification of sperm antigens using serum samples from individuals with and without antisperm antibodies

The aim of the study was to identify human sperm antigens reacting with polyclonal antisperm antibodies. Protein sperm extracts were subjected to electrofocusing, and next immune reactions (immunoblotting) were carried out with positive for antisperm antibodies and control (not containing antisperm antibodies) serum samples. Proteomic analysis of human sperm proteins resulted in identification of 80 sperm antigens that could be divided into three groups: antigens specific for patients with antisperm antibodies (32), antigens recognised by both infertile patients and control sera (35) and antigens detected by control serum samples only (13). Among antigens specific for infertile patients, there were 12 sperm entities known to be involved in fertilisation process. We have also characterised three protein entities identified only by sera of infertile women. Altogether, the proteomic analysis resulted in identification of 27 sperm entities not reported previously in human sperm proteome. Identified proteins are sperm antigens that could be potentially responsible for immunological infertility. The study also sheds new light on the sperm antigens in aspect of gender specificity. The investigation of human sperm proteome by the use of antisperm antibodies‐containing sera of infertile individuals not only may indicate new proteins but also can draft their immunological nature.
Design and validation of hydraulic pump system driven by the electromotor under the high-power and long-time working state in an airborne

This paper introduced a type of aircraft electric hydraulic pump system working principle, the key points of the system are analyzed and described, including calculation of boost pressure, system oil temperature control design, environmental temperature checking, starting logic design, the system validation and verification methods are expounded. This system passed through the ground test and flight time Validation, and worked well and reliably.
Differential Responses of Forage Pearl Millet Genotypes to Chinch Bug (Heteroptera: Blissidae) Feeding

ABSTRACT Chinch bug, Blissus leucopterus leucopterus (Say) (Heteroptera: Blissidae), is one of the most important insect pests on forage pearl millet, Pennisetum glaucum L. R. Br. , production in the southeastern United States. Twenty-nine forage pearl millet genotypes were assessed for chinch bug resistance by using stunt and necrosis ratings in combination with quantitative measurements of chlorophyll content and leaf photosynthetic rate. Plant stunt and leaf sheath necrosis ratings, and chlorophyll content in flag leaves differed among the 29 genotypes. Photosynthetic rate differed both among the noninfested control and among the chinch bug-infested plants. The chinch bug-infested plants had lower photosynthetic rate than the noninfested control plants. Inbreds with resistance superior to that of Tift 23DB were identified for hybrid development. When the 29 pearl millet genotypes were assessed by the six parameters by using cluster analysis, genotypes 07F-1226, 07F-1229, 07F-1231, 07F-1235, 07F-1238, 07F-1239, and 07F-1240 were the most resistant, whereas the genotypes 07F-1220, 07F-1221, 07F-1225, 07F-1227, 07F-1232, 07F-1246, and Tift 23DB were the most susceptible to chinch bug feeding. The rest of the genotypes expressed intermediate responses to the six parameters. To differentiate the physiological impact of chinch bug feeding on light and dark reactions of plant photosynthesis, photosynthesis capacity was assessed using light and CO2 (A/Ci) response curves on noninfested and chinch bug-infested plants of genotypes 07F-1246, 07F-1223, and 07F-1245, which expressed low, intermediate, and high chlorophyll content, respectively. Based on the A/Ci curves, photosynthesis capacity of injured leaves was suppressed in 07F-1223 and 07F-1246, whereas the chinch bug-injured 07F-1245 leaves showed an increase of photosynthetic rate compared with the noninfested plants. In contrast, light response curves were suppressed in the chinch bug-injured plants compared with the noninfested plants of all three genotypes, irrespective of their variations in insect injury ratings. This research demonstrated that visual stunt and necrosis rating methods in combination with chlorophyll and photosynthesis measurements could be used in screening forage pearl millet for chinch bug resistance and deciphering the underlying resistance mechanisms.
Exploring Reductions in London Underground Passenger Journeys Following the July 2005 Bombings

We examine the reduction in London Underground passenger journeys in response to the July 2005 bombings. Using entrance data for London Underground stations between 2001 and 2007, we incorporate demand and supply factors in a multivariate time‐series regression model to estimate changes in passenger journeys between different Underground lines. We find that passenger journeys fell by an average of 8.3% for the 4 months following the attacks. This amounts to an overall reduction of 22.5 million passenger journeys for that period. Passenger journeys returned to predicted levels during September 2005, yet we find evidence of reduced travel until June 2006. Our estimates controlled for other factors, including reduced Underground service provision due to damage from the attacks, economic conditions, and weather, yet substantial reductions in passenger journeys remained. Around 82% of passenger journey reductions following the 2005 attacks cannot be attributed to supply‐side factors or demand‐side factors such as economic conditions, weather, or the summer school‐break alone. We suggest that this reduction may partially be due to an increased perception of the risk of Underground travel after the attacks.
Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene

To identify genes associated with schizophrenia, DNA microarray chips were used to compare schizophrenia and control hippocampus tissues, revealing four genes with elevated expression, chondrex (or YKL‐40), histamine‐releasing factor, HERC2, and heat‐shock 70. However, using the quantitative real‐time polymerase chain reaction method, only the expression of the chondrex gene, an extracellular matrix glycoprotein involved in cell growth and migration, was found to be significantly elevated, by 1.8‐fold. Real‐time PCR found that the expression of the histamine‐releasing factor gene, known to be associated with cognitive deficits in Alzheimer's disease, was significantly reduced by 19%. The expression of the HERC2 and heat‐shock 70 genes, as measured by real‐time PCR, were not significantly altered in the schizophrenia hippocampus. The altered gene expression of chondrex suggests that disruption in neuronal migration may be involved in schizophrenia. The change in expression of the histamine‐releasing factor gene suggests that this gene may be associated with the negative symptoms of impaired learning and memory in schizophrenia. Synapse 50:29–34, 2003. © 2003 Wiley‐Liss, Inc.
Blind separation of instantaneous mixture of sources via an independent component analysis

In this paper, we introduce a procedure for separating a multivariate distribution into nearly independent components based on minimizing a criterion defined in terms of the Kullback-Leibner distance. By replacing the unknown density with a kernel estimate, we derive useful forms of this criterion when only a sample from that distribution is available. We also compute the gradient and Hessian of our criteria for use in an iterative minimization. Setting this gradient to zero yields a set of separating functions similar to the ones considered in the source separation problem, except that here, these functions are adapted to the observed data. Finally, some simulations are given, illustrating the good performance of the method.
Physicochemical and antioxidant composition of fresh peach palm (Bactris gasipaes Kunth) fruits in Costa Rica

The variability of the physicochemical composition, carotenoid and polyphenol contents and hydrophilic antioxidant capacity of fresh peach palm (Bactris gasipaes) fruit was studied with a view to its exploitation as a potential source of bioactive compounds. The variability present in five batches of peach palm fruit obtained from two regions in Costa Rica: Tucurrique (T) and Perez Zeledon (PZ), was studied. Significant differences were found for fruit weight, length and width amongst the batches studied. The moisture, fat and protein contents of the Tucurrique fruit were significantly lower than those from Perez Zeledon. No significant difference in starch content was found between any of the batches of peach palm fruit studied. In terms of antioxidant compounds, the total carotenoid content ranged between 109 and 202 µg β-carotene equivalents/g dry weight (dw), while the total polyphenol content varied from 54 to 106 mg gallic acid equivalents (GAE) /100 g (dw). Both these components presented variability amongst the five batches. The antioxidant capacity was determined by the ORAC method and only the PZ 3 sample presented significant differences from the other four batches. The average hydrophilic antioxidant capacity was 37 ± 7 µmol of Trolox equivalents (TE)/g (dw). Overall, the peach palm fruit showed potential to be used in the development of functional foods since the variability of the raw peach-palm fruit, determined by applying a principal component analysis, showed that some characteristics of this fruit were not affected by harvest time and showed no differences between the batches from the two areas.
A new Multi-rate Multicast Congestion Control protocol

IP multicast is an efficient distribution of data simultaneously to multiple receivers. Multi-rate Multicast Congestion Control (MR-MCC) is a promising opportunity to tackle the multicast congestion control problem in huge and heterogeneous networks like the global Internet. [1] However, it is not easy to provide a MR-MCC design with responsiveness, efficiency of network utilization, low packet loss, scalability and fairness. In this paper we present a new experimental MR-MCC protocol. Experiments show that the new protocol can effectively control network congestion and it also has a good timing performance.
Proteomic characterization of the multiple forms of the PLAs from the venom of the social wasp Polybia paulista

The phospholipases A1 (PLA1s) from the venom of the social wasp Polybia paulista occur as a mixture of different molecular forms. To characterize the molecular origin of these structural differences, an experimental strategy was planned combining the isolation of the pool of PLAs from the wasp venom with proteomic approaches by using 2‐D, MALDI‐TOF‐TOF MS and classical protocols of protein chemistry, which included N‐ and C‐terminal sequencing. The existence of an intact form of PLA1 and seven truncated forms was identified, apparently originating from controlled proteolysis of the intact protein; in addition to this, four of these truncated forms also presented carbohydrates attached to their molecules. Some of these forms are immunoreactive to specific‐IgE, while others are not. These observations permit to raise the hypothesis that naturally occurring proteolysis of PLA1, combined with protein glycosylation may create a series of different molecular forms of these proteins, with different levels of allergenicity. Two forms of PLA2s, apparently related to each other, were also identified; however, it was not possible to determine the molecular origin of the differences between both forms, except that one of them was glycosylated. None of these forms were immunoreactive to human specific IgE.