Miracle-dz/UniFAR-FTUs huggingface dataset:
The ajmaline challenge and a strange ECG: reply

We have read with interest the letter by Dr Martini and we are grateful for his comments. We would like to reply to some of the issues raised by Dr Martini in his letter. The authors are aware that ajmaline was used as a diagnostic tool in the past to unmask intraventricular conduction delays. However, nowadays sodium channel blocker challenge is an accepted and established tool to unmask the ECG pattern diagnostic of the Brugada syndrome.1 This test is especially important in the circumstance when the …
Enhanced Deep‐Learning Prediction of Molecular Properties via Augmentation of Bond Topology

Deep learning has made great strides in tackling chemical problems, but still lacks full‐fledged representations for three‐dimensional (3D) molecular structures for its inner working. For example, the molecular graph, commonly used in chemistry and recently adapted to the graph convolutional network (GCN), is inherently a 2D representation of 3D molecules. Herein we propose an advanced version of the GCN, called 3DGCN, which receives 3D molecular information from a molecular graph augmented by information on bond direction. While outperforming state‐of‐the‐art deep‐learning models in the prediction of chemical and biological properties, 3DGCN has the ability to both generalize and distinguish molecular rotations in 3D, beyond 2D, which has great impact on drug discovery and development, not to mention the design of chemical reactions.
A NOVEL APPROACH FOR DETECTING DDoS ATTACK IN H-IDS USING ASSOCIATION RULE

Across the globe, all the companies are marching towards data security and data protection. Prevention measures are taken to secure their database from an intruder. As the technology grows rapidly for information/data security, the intruders also use various techniques to exploit data on other side. Distributed Denial of Service (DDoS) attack is used to override the security of targeted system, where the attacker seeks to make a terminal unavailable to its authorized users temporarily by sending "n" number of packets over the network. The triggered DDoS attack interrupts any normal operation in a network and not letting the legitimate users to access the machine. Simply, the DDoS floods the targeted machine not to do any further actions. This examination is conveyed to distinguish DDoS attack in OSSEC HIDS, and successful measures to decrease false positive rate. "OSSEC (HIDS)"[1] has brought together, cross stage design enabling different frameworks to be effortlessly observed, overseen and simple to get the recorded logs. The extracted report was analyzed with "ASSOCIATION RULE" using Weka open source tool.
Survey on secure search over encrypted data on the cloud

Cloud computing has become a potential resource for businesses and individuals to outsource their data to remote but highly accessible servers. However, the potential of cloud services has not been fully realized due to users concerns about data privacy and security. User‐side encryption techniques can be employed to mitigate the security concerns, but once the data is encrypted, no processing (eg, searching) can be performed on the outsourced data. Searchable Encryption (SE) techniques have been widely studied to enable searching on the data while they are encrypted. These techniques enable various types of search on the encrypted data and offer different levels of security. While these techniques enable different search types and vary in details, they share similarities in their components and architectures. In this paper, we provide a comprehensive survey on different secure search techniques, a high‐level architecture for these systems, and an analysis of their performance and security level.
Altered functional connectivity in the fear network of firefighters with repeated traumatic stress.

BACKGROUND Firefighters are routinely exposed to various traumatic events and often experience a range of trauma-related symptoms. Although these repeated traumatic exposures rarely progress to the development of post-traumatic stress disorder, firefighters are still considered to be a vulnerable population with regard to trauma.AimsTo investigate how the human brain responds to or compensates for the repeated experience of traumatic stress. METHOD We included 98 healthy firefighters with repeated traumatic experiences but without any diagnosis of mental illness and 98 non-firefighter healthy individuals without any history of trauma. Functional connectivity within the fear circuitry, which consists of the dorsal anterior cingulate cortex, insula, amygdala, hippocampus and ventromedial prefrontal cortex (vmPFC), was examined using resting-state functional magnetic resonance imaging. Trauma-related symptoms were evaluated using the Impact of Event Scale - Revised. RESULTS The firefighter group had greater functional connectivity between the insula and several regions of the fear circuitry including the bilateral amygdalae, bilateral hippocampi and vmPFC as compared with healthy individuals. In the firefighter group, stronger insula-amygdala connectivity was associated with greater severity of trauma-related symptoms (β = 0.36, P = 0.005), whereas higher insula-vmPFC connectivity was related to milder symptoms in response to repeated trauma (β = -0.28, P = 0.01). CONCLUSIONS The current findings suggest an active involvement of insular functional connectivity in response to repeated traumatic stress. Functional connectivity of the insula in relation to the amygdala and vmPFC may be potential pathways that underlie the risk for and resilience to repeated traumatic stress, respectively.Declaration of interestNone.
Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity.

INTRODUCTION Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS mRNA expression of adipokines; adiponectin, resistin, tumour necrosis factor-a, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, and cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. RESULTS We did not find any significant difference in the investigated genes; however, the almost significant overexpression of AGT and underexpression of IL-6 might be noteworthy (p = 0.06 in both cases). CONCLUSIONS No significant differences were found in the expression of the investigated genes known as cardiometabolic risk factors. This indicates that there are no major differences between endogenous hypercortisolism or diet-induced obesity regarding the expression of adipokines involved in cardiometabolic disorders. However, the difference in AGT and IL-6 expression might be included in pathways affecting fat distribution in CS.
Time-safety trade-offs and a bang-bang algorithm for kinodynamic planning

The kinodynamic planning problem is, given a robot system, to find a trajectory from a start state to a goal state, while avoiding obstacles by a safety margin delta (v) and respecting dynamics bounds. Provably good polynomial-time approximation algorithms for optimal kinodynamic planning find trajectories within in of optimal and have a time complexity polynomial in 1/ in and in the geometric complexity of the robot world. The authors obtain such algorithms to find near-optimal trajectories obeying piecewise constant extremal controls and bang-bang control. Previous provably good kinodynamic planning algorithms for robot arms produce nonextremal, and hence locally nonoptimal trajectories. Using parameters in /sub T/ and in /sub S/ and describe closeness to optimality in execution time and observance of the safety margin, the authors derive equicomplexity curves to show how their algorithms permit to tradeoffs between time and safety. <<ETX>>
A Mixed-Method Evaluation of a College Student Fitness Program Using the RE-AIM Framework

Background: The consistently rising obesity rate in college student population illustrates the need for organized and effective interventions. The purposes of this study were to evaluate an eight-week fitness program implemented at university student recreation center using mixed-methods along the reach, effectiveness, and implementation dimensions of the RE-AIM framework for evaluating health-promotion programs and to illustrate how qualitative data can be used to enhance the capabilities of the RE-AIM framework to evaluate such programs via providing recommendations to improve the intervention not possible with just a quantitative RE-AIM evaluation. Methods: Quantitative (participation rate, changes in % body fat, and resting heart rate) and qualitative methods (focus groups, interviews, and surveys) were used in the study. Participants in the evaluation were program users. Results: The program reach (1.5/100) and effectiveness (8.5/100) were low, with moderate implementation on the individual level (45.5/100) and high implementation on the organizational level (79/100). Major qualitative themes illustrated that the program‟s strong points were in facilitating physique improvements (n = 11), increasing knowledge (n = 10) and motivation (n = 7) and program shortcomings were primarily due to the quality of personal training (n = 52) and the program dietician services (n = 14). Implications: Such programs often suffer from diminished effectiveness when delivered in the real world, as evident in the present study. The results of the study evaluation can help in the development of effective health promotion programs for the college student population. Suggestions for practice via the RE-AIM framework in conjunction with qualitative analyses are included.
The most probable neural circuit exhibits low-dimensional sustained activity

Cortical neurons whose activity is recorded in behavioral experiments has been classified into several types such as stimulus-related neurons, delay-period neurons, and reward-related neurons. Moreover, the population activity of neurons during a reaching task can be described by dynamics in low-dimensional space. These results suggest that the low-dimensional dynamics of a few types of neurons emerge in the cerebral cortex that is trained to perform a task. This study investigates a simple neural circuit emerges with a few types of neurons. Assuming an infinite number of neurons in the circuit with connection weights drawn from a Gaussian distribution, we model the dynamics of neurons by using a kernel function. Given that the system is infinitely large, almost all capable circuits approximate the most probable circuit for the task. We simulate two delayed response tasks and a motor-pattern generation task. The model network exhibits low-dimensional dynamics in all tasks. Considering that the connection weights are drawn from a Gaussian distribution, the most probable circuit is the circuit with the smallest connection weight; that is, the simplest circuit with the simplest dynamics. Finally, we relate the dynamics to algorithmic information theory.
Reveal the Type of Micro-Units as a Living Place in Jakarta Apartments

Micro-units is a term for a living place with the smallest size in its market which fully equipped with kitchen and bathroom. The emergence of micro-units triggered by the increment of affordable housing demand and changes of household size. In Indonesia (in the second quarter of 2017), affordable housing sales rate increase to 72.3% with 34.8% in the range of price 300–500 million rupiahs and 37.5% 500 million-1 billion rupiahs. In Jakarta, the average number of households decrease 5% from 2010 to 2015. However, until now there has not been a specific study of this phenomenon in Jakarta. This research examines the type of micro-units using the typological analysis to explore five case study apartments to find the most frequently appear result based on statistical data. The study includes the unit size and proportion, numbers of rooms, zoning and privacy level, wet-area positioning, balcony and window opening. The finding of this research reveals the type of micro-units in Jakarta is the studio to two-bedroom which sized less than 45 m2 including bedroom, kitchen, bathroom, and balcony.
Myrian Nunomura PARENTS ' SUPPORT IN THE SPORTS

From the very first moment of entrance in sports up to the time of their successful achievements, parents have a pronounced influence on the sport’s career of their children. This influence is readily seen when the parent’s dedicated involvement and investment, both emotional and financial, put into the support they give to their children in sports is taken into account. This is all done with the objective that their young athlete may stay involved and reach their full potential. To describe the parental support in the context of Brazilian Artistic Gymnastics in formative categories, this study addressed the perceptions that young gymnasts have toward the behavior and attitude of their parents through a field research conducted among 29 sport institutions involving a total of 163 athletes. We have found that parental support enabled and greatly influenced the child’s entering into sports, their access to the practice of a sport, their level of participation, their degree of involvement, and their physical and emotional wellbeing. Moreover, the parental support is crucial to the commitment and dedication of the young gymnast. However, when this support is perceived in a negative way it can result in stress, conflicts between parents and children, burnout and may provoke dropout.
Evaluation of Pulsed I–V Analysis as Validation Tool of Nonlinear RF Models of GaN-Based HFETs

This paper evaluates the applicability of pulsed <italic>I</italic>–<italic>V</italic> measurements as a tool for accurately extracting nonlinear gallium nitride (GaN)-based heterojunction field-effect transistor (HFET) models. Two wafers with the identical layer structure but different growth conditions have been investigated. A series of <italic>I</italic>–<italic>V</italic> measurements was performed under dc and pulsed conditions demonstrating a dramatic difference in the kink effect and current collapse (knee walkout) suggesting different trapping behaviors. However, when radio frequency (RF) <italic>I</italic>–<italic>V</italic> waveform measurements, utilizing active harmonic load–pull, were used to study the impact of these traps on the RF performance, both wafers gave good overall RF performance with no significant difference observed. This absence of correlation between pulsed <italic>I</italic>–<italic>V</italic> measurement results and RF performance raises a question about the applicability of pulsed <italic>I</italic>–<italic>V</italic> measurements alone as a tool for extracting nonlinear device models in the case of GaN HFETs.
Real-Time Continuous-Scale Image Interpolation with Directional Smoothing

A real-time, continuous-scale image interpolation method is proposed based on a bilinear interpolation with directionally adaptive low-pass filtering. The proposed algorithm was optimized for hardware implementation. The ordinary bi-linear interpolation method has blocking artifacts. The proposed algorithm solves this problem using directionally adaptive low-pass filtering. The algorithm can also solve the severe blurring problem by selectively choosing lowpass filter coefficients. Therefore, the proposed interpolation algorithm can realize a high-quality image scaler for a range of imaging systems, such as digital cameras, CCTV and digital flat panel displays.
Uses and Gratifications Sought From Mobile Phones and Loneliness Among Japanese Midlife and Older Adults: A Mediation Analysis

Abstract Background and Objectives Mobile phone use is increasing among older adults, yet few studies have examined how the various purposes for which mobile phones are used affect loneliness and through what mechanisms. This study aims to address the gap by examining if different uses and gratifications of mobile phone are associated with loneliness and whether there is a mediation effect through face-to-face social interaction. Research Design and Methods Participants included 1,318 mobile phone users drawn from a national probability sample of Japanese middle-aged (65% aged 40–64 years) and older adults (35% aged 65 years or older) in 2011. Ordinary Least Squares regression and mediation analyses were used. Results Regression analyses revealed that using a mobile phone for sociability purposes was associated with decreased loneliness (b = −0.10, p < .001), while using it for the purposes of entertainment/passing time was associated with increased loneliness (b = 0.04, p < .01); some effects varied by age and mobile phone feature use. Further, sociability was associated with increased face-to-face social interaction, which was, in turn, associated with reduced loneliness. Passing time, however, was related to reduced face-to-face interaction and, in turn, an increased sense of loneliness. Discussion and Implications Although it is not possible to determine causality from this cross-sectional design, it is possible that the various purposes for which mobile phones are used (specifically sociability and passing time) partially affect loneliness through their effects on either increasing or decreasing face-to-face social interaction. Recommendations for enhancing positive and reducing negative effects of mobile phone usage are discussed.
Automated Quantification of Vocal Fold Motion in a Recurrent Laryngeal Nerve Injury Mouse Model

The goal of this study was to objectively examine vocal fold (VF) motion dynamics after iatrogenic recurrent laryngeal nerve (RLN) injury in a mouse surgical model. Furthermore, we sought to identify a method of inducing injury with a consistent recovery pattern from which we can begin to evaluate spontaneous recovery and test therapeutic interventions.
Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alternative for voltammetric analyses, mainly, when associated with screen-printing technologies (screen-printed electrodes, SPEs), and microfluidic platforms. The aim of this paper is to discuss a carefully selected literature about different examples of SPEs-based immunosensors associated with microfluidic technologies for diseases, food, agricultural and environmental analysis. Technological aspects of the development of the voltammetric immunoassays such as the signal amplification, construction of paper-based microfluidic platforms and the utilization of microfluidic devices for point-of-care testing will be presented as well.
Cornerstones and epilogue of the GRFM Africa project: a gallery of regional scale vegetation maps

The Global Rain Forest Mapping project (GRFM) is an initiative started by the National Agency for Space Development of Japan (NASDA) in 1996 with the main goal of creating a wall to wall radar map of the tropical belt with homogeneous and consistent characteristics. GRFM Africa-the part of the project related to tropical Africa-has evolved through several years to the stage where significant thematic products have been generated. It is maintained that these products bear relevance to global change studies and to the sustainable management of local resources in the tropics. The objective of this paper is to lend support to this proposition by illustrating through a few examples the results achieved so far. In particular two land cover maps are presented covering respectively the Central Congo basin, and the Gabon country. Validation of these large-scale high-resolution products poses a challenging problem. The method adopted in GRFM Africa is outlined. It is based on comparison with independent thematic information with known error budget, derived from a combination of optical remote sensing observations, national forestry maps and ground surveys.
Coping ability and everyday life situations in relation to audiological rehabilitation

The relationship between the reported use of coping strategies and experience of everyday life prior to audiological rehabilitation and the number of rehabilitation consultations needed, were studied in a group of adults. The study took place at St. Olav's University Hospital, Norway and included 132 adult patients (77 men and 55 women) with no previous audiological rehabilitation or experience with hearing aid (HA) use. Hearing impairment was assessed by pure tone audiometry, while use of communication specific coping strategies and daily life situations were obtained using self-report inventories. The latter concerned activity limitation, participation restriction, and psychological well-being. The patients’ hospital records were reviewed approximately 18 months after their first consultation. In total, 41 patients (31%) needed no more than the required minimum number of three consultations to complete rehabilitation including HA fitting, while 91 patients needed more than this. Logistic regression was used to study coping and everyday life in relation to the need for three versus more consultations. Little experienced participation restriction was related to the need for only three consultations. Use of communication specific coping strategies, activity limitation, or psychological well-being was not associated with the number of consultations needed.