Miracle-dz/UniFAR-FTUs huggingface dataset:
PII: S1010-7940(02)00179-3

Objectives: This study was designed to determine the long-term prognosis of video-assisted thoracic surgery (VATS) vs. open lung resections for patients with pathological stage I non-small cell lung cancer (NSCLC). Materials and methods: The medical records of all patients who underwent lung resection for a pathological stage I NSCLC were reviewed for the period from 1990 to 1999, by screening of a database into which data were entered prospectively. There were 511 patients (430 males and 81 females) whose age averaged 63 ^ 10 years who underwent 515 lung resections. Our VATS experience began in 1993 with selected stage I patients, and since that date an average of one patient on four was managed with VATS. Lung resections consisted of 25 wedge resections or segmentectomies (seven VATS), 390 lobectomies (92 VATS), 19 bilobectomies (one VATS) and 81 pneumonectomies (ten VATS). Lymph node dissection was performed in all cases. Results: There were significantly more females ðP 1⁄4 0:01Þ and adenocarcinoma ðP 1⁄4 0:02Þ in the VATS group ðn 1⁄4 110Þ when compared to the open group ðn 1⁄4 405Þ. Tumour size averaged 4 ^ 2 cm in the open group and 3 ^ 2 cm in the VATS group ðP 1⁄4 0:04Þ. The distribution of T1/T2 tumours was 97/308 and 50/60, respectively ðP 1⁄4 0:0001Þ. At follow-up, cancer recurrence could be documented in 117 patients, with no difference of incidence between the two groups (22.5 vs. 24.5%; P 1⁄4 0:64). Estimated Kaplan–Meier 5-year survival rates, including the operative mortality as well as any cancer-related and unrelated death, were 62.8% (confidence interval (CI): 56.8–68.7%) vs. 62.9% (CI: 51.4–74.4%), respectively ðP 1⁄4 0:60Þ. The advent of VATS did not influence the patients’ survival: 5-year survival rate was 63.9% (CI: 55.3–72.5%) for the period from 1990 to 1992, and 58.8% (CI: 51.7–65.9%) for the period from 1993 to 1999 ðP 1⁄4 0:65Þ. Subgroups survival analysis according to the T status did not show any statistically significant difference between the two groups. Conclusions: VATS lung resection with lymph node dissection achieved a 5-year survival similar to that achieved by the conventional approach. VATS is a valuable option for the management of selected patients with an early-stage NSCLC. q 2002 Elsevier Science B.V. All rights reserved.
Practice Concepts Development of a Test of Physical Performance for the Nursing Home Setting

Purpose: This study was undertaken to develop a perfor-mance-based instrument to measure a range of function present among nursing home (NH) residents and to establish the reliability and validity of the measures. Design and Methods: Fourteen items integral to daily life in a NH setting were administered to 95 NH residents with sufficient cognitive ability to follow a one-step command at baseline, 1 week later, and 6 months later. Intraclass correlation coefficients and Cronbach’s coefficient alpha were calculated for reliability estimates. The Minimum Data Set (MDS), Katz, and Multidimensional Observational Scale for Elderly Subjects (MOSES) were used to establish concurrent validity. Factor analysis, correlation matrices, and other objective criteria were used for item reduction. Results: Test– retest reliability for items ranged between . 73 and . 93. Factor analysis and correlations between Nursing Home Physical Performance Test (NHPPT) items and scales with measures of activities of daily living (ADL) suggest that the NHPPT taps aspects of gross motor function (Factor 1) and fine motor coordination and task sequencing (Factor 2) required for ADL function and mobility. The NHPPT may also tap aspects of ADL function and mobility not measured by the MDS ( r (cid:2) –. 72–. 75), MOSES ( r (cid:2) –. 82–. 84), or Katz ( r (cid:2) –. 75–. 77) scales. Effect sizes based on mean change scores were larger for the NHPPT scales (.38–.53) than for the other functional scales (.27–.33). Implications: The NHPPT is a reliable performance-based instrument that dis-criminates among frail NH residents. Further studies are necessary to assess the value of this instrument for prediction and monitoring of functional status in the NH.
Brief Report

B-cell chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world. We have previously shown that transgenic mice overexpressing TCL1 gene in B cells (EmTCL1) develop the aggressive form of CLL and that aggressive human CLLs overexpress Tcl1. These results indicate that dysregulation of TCL1 is critically important in the pathogenesis of the aggressive form of CLL. Because Em-TCL1 mice developed CLL in relatively old age, it is likely that deregulation of Tcl1 is an initiating event in CLL pathogenesis, but additional genetic changes are necessary for CLL development. To identify these changes, we performed genetic screen in Em2TCL1 mice using Sleeping Beauty (SB) transposon-mediated mutagenesis. The Sleeping Beauty approach is based on the ability of SB transposons containing murine stem-cell virus long terminal repeat and splice donor site to activate the expression of nearby oncogenes. This system was successfully used in the past to identify genes contributing to development of several tumor types.
MINIREVIEW Chlamydial Persistence: beyond the Biphasic Paradigm

The chlamydiae are an evolutionarily distinct group of eu-bacteria sharing an obligate intracellular lifestyle and a unique developmental cycle that has been well characterized under favorable cell culture conditions. This cycle begins when infectious, metabolically inert elementary bodies (EB) attach to and stimulate uptake by the host cell. The internalized EB remains within a host-derived vacuole, termed an inclusion, and differ-entiates to a larger, metabolically active reticulate body (RB). The RB multiplies by binary ﬁssion, and after 8 to 12 rounds of multiplication, the RB differentiate to EB asynchronously (78). At 30 to 84 h postinfection (PI), depending primarily on the infecting species, EB progeny are released from the host cell to initiate another cycle (78, 122). bacterial nature of
iMobile: A Framework to Implement Software Agents for the iOS Platform

— Appropriate implementation of software agents for the iOS platform able to represent their main features, such as distribution, autonomy and pro-activity, is still an open issue. Therefore, this paper proposes the iMobile Framework that allows the creation of software agents for applications (apps) made for iPhone and iPad devices. A developed scenario demonstrates the applicability of the proposed framework, where an app allows registration of issues identified in some company. The main goal of the software agents is to speed up the process of contacting people, as quickly as possible, to solve critical issues.
(2017). Information and choice of A-level subjects: a cluster randomized controlled trial with linked administrative data.

We estimated the effects of an intervention which provided information about graduate wages to 5,593 students in England, using a blinded cluster randomised controlled trial in 50 schools (registration:AEARCTR-0000468). Our primary outcome was students’ choice of A-level subjects at age 16. We also recorded the students’ expectations of future wages and the A-level subjects they intended to take before and after the intervention, and linked their data into national administrative school examination records. We found that an hour-long lesson on information about graduate wages affected students’ beliefs about and choice of subject. They were more likely to take Maths and less likely to take Biology and Computing. We found strong evidence that mediating factors such as their beliefs about average graduate salaries and their own likely salary in each subject were affected by the intervention. This suggests providing accessible and credible information on labour market consequences of school choices may influence students’ decisions. In the light of concerns about the quality of careers guidance for school students and expectations that educational choices should be well-informed, the study has clear implications for policy and practice.
(2015). The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function. Frontiers in Cellular Neuroscience ,

The application of next-generation-sequencing based methods has recently allowed the sequence-speciﬁc occurrence of RNA modiﬁcations to be investigated in transcriptome-wide settings. This has led to the emergence of a new ﬁeld of molecular genetics research termed “epitranscriptomics. ” Investigations have shown that these modiﬁcations can exert control over protein synthesis via various mechanisms, and particularly when occurring on messenger RNAs, can be dynamically regulated. Here, we propose that RNA modiﬁcations may be a critical regulator over the spatiotemporal control of protein-synthesis in neurons, which is supported by our ﬁnding that the RNA methylase NSun2 colocalizes with the translational-repressor FMRP at neuronal dendrites. We also observe that NSun2 commonly methylates mRNAs which encode components of the postsynaptic proteome, and further ﬁnd that NSun2 and FMRP likely share a common subset of mRNA targets which include those that are known to be translated at dendrites in an activity-dependent manner. We consider potential roles for RNA modiﬁcations in space- time- and activity-dependent regulation of protein synthesis in neuronal physiology, with a particular focus on synaptic plasticity modulation.
Edinburgh Research Explorer Detection of quantitative trait loci for backfat thickness and intramuscular fat content in pigs (Sus scrofa)

In an experimental cross between Meishan and Dutch Large White and Landrace lines, 619 F 2 animals and their parents were typed for molecular markers covering the entire porcine genome. Associations were studied between these markers and two fatness traits: intramuscular fat content and backfat thickness. Association analyses were performed using interval mapping by regression under two genetic models: (1) an outbred line-cross model where the founder lines were assumed to be ﬁxed for different QTL alleles; and (2) a half-sib model where a unique allele substitution effect was ﬁtted within each of the 19 half-sib families. Both approaches revealed for backfat thickness a highly signiﬁcant QTL on chromosome 7 and suggestive evidence for a QTL at chromosome 2. Furthermore, suggestive QTL affecting backfat thickness were detected on chromosomes 1 and 6 under the line-cross model. For intramuscular fat content the line-cross approach showed suggestive evidence for QTL on chromosomes 2, 4, and 6, whereas the half-sib analysis showed suggestive linkage for chromosomes 4 and 7. The nature of the QTL effects and assumptions underlying both models could explain discrepancies between the ﬁndings under the two models. It is concluded that both approaches can complement each other in the analysis of data from outbred line crosses. the test statistic under the null hypothesis of no QTL is the trait of individual j , originating sire associated with the under study. A total of 10,000 ; is the average effect for half-sib family i ; b is the regression were sufﬁcient to estimate chromosomewise 5, coefﬁcient within half-sib family i ( i.e. , substitution effect for 1, and 0.1% signiﬁcance thresholds. To estimate smaller risk a putative QTL); x ij is the conditional probability for individual levels the number of permutations was extended to 50,000. e ij the higher BFT or IMF. If it could be inferred unequivocally which of the sire’s marker alleles originated from the Meishan it could subsequently be determined whether this Meis-this han allele was associated with an increase or a decrease in marker Signiﬁcance take
Cell Rb and hematopoiesis: stem cells to anemia

The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role in various cellular processes. The application of conditional somatic mutation with lineage and temporally controlled gene deletion strategies, thus circumventing the lethality associated with germ-line deletion of Rb, have allowed for a reanalysis of the in vivo role of Rb. In the hematopoietic system, such approaches have led to new insights into stem cell biology and the role of the microenvironment in regulating hematopoietic stem cell fate. They have also clarified the role that Rb plays during erythropoiesis and defined a novel mechanism linking mitochondrial function to terminal cell cycle withdrawal. These studies have shed light on the in vivo role of Rb in the regulation of hematopoiesis and also prompt further analysis of the role that Rb plays in both the regulation of hematopoietic stem cells and the terminal differentiation of their progeny. BCL11A associated with persistent fetal hemo- globin and amelioration of the phenotype of beta-tha-lassemia.
of teacher ratings of problem behavior for development of adult schizotypal symptoms: a follow-up of a

How school-associated behavioral problems in childhood and adolescence precede distinctive adult schizotypal symptoms was examined. Gender specific findings were explored. 159 patients of the Department of Child and Adolescent Psychiatry of the University Medical Centre Utrecht, the Netherlands, were reassessed aft er 11.6 ( SD =3.1) years for adult schizotypal symptoms. Severity of behavioral symptoms in childhood and adolescence using Teacher Report Form (TRF; Verhulst et al., 1997) and adult schizotypal symptoms using Schizotypal Personality Questionnaire-Revised (Raine, 1991) were examined by Spearman’s bivariate correlations. Multiple regression analyses were performed to determine the combined predictive value of significant TRF subscales for schizotypal symptomatology. Moderation was tested by adding the interactions of gender with TRF subscales to the models. Disregarding gender, correlational analyses revealed that TRF total problems, in specific thought problems, social problems, and attentional problems were associated with disorganized schizotypal symptoms in adult life. TRF thought problems was also associated with future positive schizotypal symptoms. When gender was taken into account, for boys only thought problems was associated with adult positive schizotypal symptoms, whereas for girls externalizing problems, specifically attentional and aggressive problems, were associated with the higher levels of adult disorganized schizotypal symptoms. Moderated regression analyses provided trend significant evidence confirming that in girls externalizing problems were positively associated with general and disorganized schizotypal symptoms. When using teachers as informants, it was found that juvenile behavioral abnormalities were diff erentially associated with type of adult schizotypal symptoms, with these associations being further modified by gender. kinship with family members diagnosed with schizophrenia. The SPQ has high internal reliability (0.91), test-retest reliability (0.82), convergent validity (0.59 to 0.81), discrimi-nant validity (0.63), and criterion validity, 0.68) (Raine, 1991). Higher scores on the SPQ-R indicate higher levels of schizotypal symptoms. alpha, for multiple testing, alpha was set to . 005, two-tailed, for all analyses. Statistical analyses were performed using the Statistical Package for the Social Sciences 18.0 (SPSS Inc, Chicago, Il, USA). but none of the three TRF subscales were significant predictors (.113< p <.296).
The Qualitative Report The Qualitative Report Bringing up the Green-Eyed Monster: Conceptualizing and Bringing up the Green-Eyed Monster: Conceptualizing and Communicating Jealousy with a Partner Who Has Other Partners Communicating Jealousy with a Partner Who Has Other Partners

Abstract This paper presents a qualitative analysis of 423 open-ended survey responses from 141 individuals involved in polyamorous intimate partnerships. Grounded in literature on jealousy and polyamory, this analysis offers a reinforcement and extension of romantic jealousy. Participants described how jealousy is conceptualized and discussed within polyamorous relationships. Conceptualizations of jealousy primarily involved jealousy as an umbrella term for insecurity, possessiveness, or needs not being met. Participants discuss jealousy within the context of partner agreements to add or remove another partner, to explicitly seek validation and acknowledgment, and less frequently meeting negative reactions. Importantly, results indicate that within polyamorous relationships, feelings of jealousy are usually communicated, and for the purpose of seeing affirmation and validation, not with the goal of behavior change. This paper presents a qualitative analysis of 423 open-ended survey responses from 141 individuals involved in polyamorous intimate partnerships. Grounded in literature on jealousy and polyamory, this analysis offers a reinforcement and extension of romantic jealousy. Participants described how jealousy is conceptualized and discussed within polyamorous relationships. Conceptualizations of jealousy primarily involved jealousy as an umbrella term for insecurity, possessiveness, or needs not being met. Participants discuss jealousy within the context of partner agreements to add or remove another partner, to explicitly seek validation and acknowledgment, and less frequently meeting negative reactions. Importantly, results indicate that within polyamorous relationships, feelings of jealousy are usually communicated, and for the purpose of seeing affirmation and validation, not with the goal of behavior change. and its “others”: Contesting the terms of non- monogamy.
The combinatorics of (k,`)-Hook Schur functions

A microphone holder having a slot for receiving the headed shank of a microphone, and a switch located for operative engagement by the shank head to electrically close the switch, so that the switch connected in an AM/FM radio will automatically disable the latter upon use of the CB radio, and return the AM/FM radio to operation upon replacement of the CB microphone in the holder.
Scaffold-mediated gating of Cdc42 signalling flux this article openly available. Please share how this access benefits you. Your story matters

Scaffold proteins modulate signalling pathway activity spatially and temporally. In budding yeast, the scaffold Bem1 contributes to polarity axis establishment by regulating the GTPase Cdc42. Although different models have been proposed for Bem1 function, there is little direct evidence for an underlying mechanism. Here, we find that Bem1 directly augments the guanine exchange factor (GEF) activity of Cdc24. Bem1 also increases GEF phosphorylation by the p21-activated kinase (PAK), Cla4. Phosphorylation abrogates the scaffold-dependent stimulation of GEF activity, rendering Cdc24 insensitive to additional Bem1. Thus, Bem1 stimulates GEF activity in a reversible fashion, contributing to signalling flux through Cdc42. The contribution of Bem1 to GTPase dynamics was borne-out by in vivo imaging: active Cdc42 was enriched at the cell pole in hypophosphorylated cdc24 mutants, while hyperphosphorylated cdc24 mutants that were resistant to scaffold stimulation displayed a deficit in active Cdc42 at the pole. These findings illustrate the self-regulatory properties that scaffold proteins confer on signalling pathways.
Learning Transductions to Test Systematic Compositionality

Recombining known primitive concepts into larger novel combinations is a quintessentially human cognitive capability. Whether large neural models in NLP acquire this ability while learning from data is an open question. In this paper, we look at this problem from the perspective of formal languages. We use deterministic ﬁnite-state transducers to make an unbounded number of datasets with con-trollable properties governing compositionality. By randomly sampling over many transducers, we explore which of their properties (number of states, alphabet size, number of transitions etc.) contribute to learnability of a compositional relation by a neural network. In general, we ﬁnd that the models either learn the relations completely or not at all. The key is transition coverage, setting a soft learnability limit at 400 examples per transition.
Fuse and Mix: MACAM-Enabled Analog Activation for Energy-Efficient Neural Acceleration

Analog computing has been recognized as a promising low-power alternative to digital counterparts for neural network acceleration. However, conventional analog computing is mainly in a mixed-signal manner. Tedious analog/digital (A/D) conversion cost significantly limits the overall system’s energy eﬃciency. In this work, we devise an eﬃcient analog activation unit with magnetic tunnel junction (MTJ)-based analog content-addressable memory (MACAM), simultaneously realizing nonlinear activation and A/D conversion in a fused fashion. To compensate for the nascent and therefore currently limited representation capability of MACAM, we propose to mix our analog activation unit with digital activation dataflow. A fully differential framework, SuperMixer, is developed to search for an optimized activation workload assignment, adaptive to various activation energy constraints. The effectiveness of our proposed methods is evaluated on a silicon photonic accelerator. Compared to standard activation implementation, our mixed activation system with the searched assignment can achieve competitive accuracy with >60% energy saving on A/D conversion and activation.
Uniform observable error bounds of Trotter formulae for the semiclassical Schrödinger equation

By no fast-forwarding theorem, the simulation time for the Hamiltonian evolution needs to be O ( (cid:107) H (cid:107) t ), which essentially states that one can not go across the multiple scales as the simulation time for the Hamiltonian evolution needs to be strictly greater than the physical time. We demonstrated in the context of the semiclassical Schr¨odinger equation that the computational cost for a class of observables can be much lower than the state-of-the-art bounds. In the semiclassical regime (the eﬀective Planck constant h (cid:28) 1), the operator norm of the Hamiltonian is O ( h − 1 ). We show that the number of Trotter steps used for the observable evolution can be O (1), that is, to simulate some observables of the Schr¨odinger equation on a quantum scale only takes the simulation time comparable to the classical scale. In terms of error analysis, we improve the additive observable error bounds [Lasser-Lubich 2020] to uniform-in- h observable error bounds. This is, to our knowledge, the ﬁrst uniform observable error bound for semiclassical Schr¨odinger equation without sacriﬁcing the convergence order of the numerical method. Based on semiclassical calculus and discrete microlocal analysis, our result showcases the potential improvements taking advantage of multiscale properties, such as the smallness of the eﬀective Planck constant, of the underlying dynamics and sheds light on going across the scale for quantum dynamics simulation.