Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders

Sleep reactivity is the trait‐like degree to which stress exposure disrupts sleep, resulting in difficulty falling and staying asleep. Individuals with highly reactive sleep systems experience drastic deterioration of sleep when stressed, whereas those with low sleep reactivity proceed largely unperturbed during stress. Research shows that genetics, familial history of insomnia, female gender and environmental stress influence how the sleep system responds to stress. Further work has identified neurobiological underpinnings for sleep reactivity involving disrupted cortical networks and dysregulation in the autonomic nervous system and hypothalamic‐pituitary‐adrenal axis. Sleep reactivity is most pathologically and clinically pertinent when in excess, such that high sleep reactivity predicts risk for future insomnia disorder, with early evidence suggesting high sleep reactivity corresponds to severe insomnia phenotypes (sleep onset insomnia and short sleep insomnia). High sleep reactivity is also linked to risk of shift‐work disorder, depression and anxiety. Importantly, stress‐related worry and rumination may exploit sensitive sleep systems, thereby augmenting the pathogenicity of sleep reactivity. With the development of cost‐effective assessment of sleep reactivity, we can now identify individuals at risk of future insomnia, shift‐work disorder and mental illness, thus identifying a target population for preventive intervention. Given that insomniacs with high sleep reactivity tend to present with severe insomnia phenotypes, patient sleep reactivity may inform triaging to different levels of treatment. Future research on sleep reactivity is needed to clarify its neurobiology, characterize its long‐term prospective associations with insomnia and shift‐work disorder phenotypes, and establish its prognostic value for mental illness and other non‐sleep disorders.
İleri Derecede bir Rinofima Olgusu: Vaka Takdimi

Burun hem fonksiyonunu engelleyen hende kozmetik deformiteye neden olan rinofima,burun cildinde bulunan sebase yapilarin benign hipertrofisinden kaynaklanmaktadir. Etiolojisi bilinmeyen bu olusumun tedavisi icin farkli medikal ve cerrahi secenekler tarif edilmistir.Medikal tedavinin genelde yetersiz kaldigi rinofima olgularinda cerrahi en cok tercih edilen yontemdir.Klinigimize basvuran 70 yasindaki erkek hastadakl ileri derece yaygin tutulumlu rinofima icin tutulan cilt grefti ile rekonstruksiyon gerceklestirilmistir.Bu olgu sunumu ile birlikte rinofimanin patofizyolojisi ve farkli tedavi secenekleri incelenmistir.
Acute effects of high-intensity exercise on hematological and iron metabolic parameters in elite male and female dragon boating athletes

ABSTRACT Objective: To investigate the acute effects of high-intensity exercise on blood hepcidin levels and other iron metabolic and hematological parameters in highly trained athletes of dragon boating as a sport performed in a sitting position. Methods: We conducted an exercise intervention study with a pre- and posttest blood measurement to determine the effects of high-intensity training on hematological and iron metabolic parameters in both male (n = 19) and female (n = 12) elite athletes of the German national dragon boating team. The study took place during the final training camp before the European championships. Blood samples were collected at baseline and 3 h after 3 consecutive high-intensity training bouts at the same day, each one lasting 1 h in duration. Results: After exercise, leukocytes, CPK, CKMB, and hepcidin levels increased significantly both in men and women. In contrast, iron concentrations decreased significantly. No gender-related differences were found. Compared with baseline, the postexercise concentrations of serum iron decreased significantly both in men [99.3 ± 46.3 to 61.2 ± 20.9 µg/dL (p < 0.001)] and in women [116.3 ± 34 to 67.1 ± 21.8 µg/dL (p < 0.001)] without a gender difference (p = 0.28). Hepcidin levels increased significantly both in men [9.1 ± 6.5 to 12.2 ± 5.8 ng/mL (p < 0.001)] and in women [8.0 ± 4.6 to 11.7 ± 5.7 ng/mL (p < 0.001)] without a significant gender difference in hepcidin changes (p = 0.34). Conclusions: In conclusion, three consecutive high-intensity training bouts lead to elevated hepcidin levels and decreased iron levels in elite athletes of dragon boating. The increase in hepcidin levels may contribute to the risk of anemia in these athletes.
Evidence for contrasting roles for prolactin in eusocial naked mole-rats, Heterocephalus glaber and Damaraland mole-rats, Fukomys damarensis

Elevated prolactin (PRL) has been associated with the expression of social and cooperative behaviours in a number of vertebrate species, as well as suppression of reproduction. As social mole-rats exhibit both of these traits, PRL is a prime candidate in mediating their social phenotype. While naked and Damaraland mole-rats (NMRs and DMRs) have evolved eusociality independently within their family, both species exhibit an extreme skew in lifetime reproductive success, with breeding restricted to a single female and one or two males. Non-breeding NMRs of both sexes are physiologically inhibited from reproducing, while in DMRs only the non-breeding females are physiologically suppressed. Newly emerging work has implicated the dopamine system and PRL as a component in socially induced reproductive suppression and eusociality in NMR, but the DMR remains unstudied in this context. To investigate evolutionary convergence in the role of PRL in shaping African mole-rat eusociality, we determined plasma PRL concentrations in breeders and non-breeders of both sexes, comparing DMRs with NMRs. Among samples from non-breeding NMRs 80% had detectable plasma PRL concentrations. As a benchmark, these often (37%) exceeding those considered clinically hyperprolactinaemic (25 ng ml−1) in humans: mean ± s.e. m. : 34.81 ± 5.87 ngml−1; range 0.00–330.30 ng ml−1. Conversely, 85% of non-breeding DMR samples had undetectable values and none had concentrations above 25 ng ml−1: 0.71 ± 0.38 ng ml−1; 0.00–23.87 ngml−1. Breeders in both species had the expected variance in plasma PRL concentrations as part of normal reproductive function, with lactating queens having significantly higher values. These results suggest that while elevated PRL in non-breeders is implicated in NMR eusociality, this may not be the case in DMRs, and suggests a lack of evolutionary convergence in the proximate control of the social phenotype in these mole-rats.
Design and implementation of a low-complexity R-peak detection algorithm

Cardiovascular disease, which is one of the most dangerous diseases in modern medicine, has become a threat to people's health. ECG is a kind of information that can reflect the physiological characteristics of human heart. With the development of modern technology, achieving ECG for health monitoring in the wearable hardware has become increasingly popular. The detection of R-peak is very important in ECG signal processing. This paper presents a low complexity r-peak detection algorithm, which is suitable for ASIC implementation. First of all, the algorithm use digital filter and envelope filter to remove the noise which is in the ECG. Then it use the Hilbert transform convert the r-peak to zero-crossing point. At last, it check the zero-crossing point to finish the R-peak detection. The algorithm is using the first-channel of the MIT-BIH arrhythmia database to test, and achieves average detection accuracy of 99.81%, sensitivity of 99.87%.
A Bone Morphogenetic Protein Subfamily : Chromosomal Localization of Human Genes for BMP 5 , BMP 6 , and BMP 7

B o n e m o r p h o g e n e t i c pro te ins (BMPs) w e r e or ig i na l ly ident i f ied by the abi l i ty o f a d e m i n e r a l i z e d bone e x t r a c t to induce en d och on d ra l o s t e o g e n e s i s in vivo. S e v e n B M P c D N A s (BMP1 through B M P 7 ) h a v e been r e c o v e r e d through m o l e c u l a r c loning . R e c o m b i n a n t prote in products f r o m s ix of these c lones (BMP2 through B M P 7 ) are m e m b e r s of the t r a n s f o r m i n g g r o w t h factor ~ (TGF-~) s u p e r f a m i l y of r egu la tory mol ecules . B a s e d upon a h igh d e g r e e of a m i n o acid sequence h o m o l o g y , B M P 5 , B M P 6 , and B M P 7 cons t i tu te a s u b f a m i l y w i t h i n the B M P s . U s i n g h u m a n r o d e n t som a t i c ce l l hybr id l ines and c D N A probes , w e mapped the three m e m b e r s o f th is s u b f a m i l y of g e n e s to the hum a n c h r o m o s o m e s . B M P 5 and B M P 6 are s y n t e n i c on h u m a n c h r o m o s o m e 6, w h i l e B M P 7 is s y n t e n i c w i t h prev i o u s l y l oca l i zed B M P 2 on h u m a n c h r o m o s o m e 20 . This ana lys i s r e v e a l s that B M P 6 maps to a c o n s e r v e d reg ion b e t w e e n the m o u s e and h u m a n g e n o m e s . Sequence a n a l y s i s s u g g e s t s that the Drosophi la 60A gene is the d ipteran h o m o l o g o f th is B M P s u b f a m i l y and m a y p r o v i d e c lues to the phys io log i c funct ions of the products o f these g e n e s in h u m a n b io logy . © 1992 Academic Press, Inc.
Discovering Primitive Action Categories by Leveraging Relevant Visual Context

Under the bag-of-features framework we aim to learn primitive action categories from video without supervision by leveraging relevant visual context in addition to motion features. We define visual context as the appearance of the entire scene including the actor, related objects and relevant background features. To leverage visual context along with motion features, we learn a bi-modal latent variable model to discover action categories without supervision. Our experiments show that the combination of relevant visual context and motion features improves the performance of action discovery. Furthermore, we show that our method is able to leverage relevant visual features for action discovery despite the presence of irrelevant background objects.
Incorporating perceptual decision-making training into high-intensity interval training for Australian football umpires

ABSTRACT Existing methods for developing decision–making skill for Australian football umpires separate the physical and perceptual aspects of their performance. This study aimed to determine the efficacy of incorporating video-based decision-making training during high-intensity interval training sessions, specific for Australian football umpires. 20 amateur Australian football umpires volunteered to participate in a randomised control trial. Participants completed an 8-week training intervention in a conditioning only (CON; n=7), combined video-based training and conditioning (COM; n=7), or separated conditioning and video-based training (SEP; n=6) group. Preliminary and post-testing involved a Yo-Yo Intermittent Recovery Test (Yo-YoIR1), and 10x300m run test with an Australian football specific video-based decision-making task. Overall, changes in decision-making accuracy following the intervention were unclear between groups. SEP was possibly beneficial compared to COM in Yo-YoIR1 performance, whereas CON was likely beneficial compared to COM in 10x300m sprint performance. There was no additional benefit to completing video-based training, whether combined with, or separate to physical training, suggesting that this was not an optimal training method. For video-based training to be an effective decision-making tool, detailed feedback should be incorporated into training. It is recommended that longer conditioning and video-based training interventions be implemented to determine training effectiveness.
Risk profiles for heavy drinking in adolescence: differential effects of gender

Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk profiles is unclear, and it is further unclear whether these risk profiles differ between genders. We combined longitudinal and cross‐sectional analyses on the large IMAGEN sample (N ≈ 1000) to predict heavy drinking at age 19 from gray matter volume as well as from psychosocial data at age 14 and 19—for males and females separately. Heavy drinking was associated with reduced gray matter volume in 19‐year‐olds' bilateral ACC, MPFC, thalamus, middle, medial and superior OFC as well as left amygdala and anterior insula and right inferior OFC. Notably, this lower gray matter volume associated with heavy drinking was stronger in females than in males. In both genders, we observed that impulsivity and facets of novelty seeking at the age of 14 and 19, as well as hopelessness at the age of 14, are risk factors for heavy drinking at the age of 19. Stressful life events with internal (but not external) locus of control were associated with heavy drinking only at age 19. Personality and stress assessment in adolescents may help to better target counseling and prevention programs. This might reduce heavy drinking in adolescents and hence reduce the risk of early brain atrophy, especially in females. In turn, this could additionally reduce the risk of developing alcohol use disorders later in adulthood.
Analysis and prediction of influenza in the UAE based on Arabic tweets

Social Networks have been used recently for detecting different events, such as diseases. In this paper, we propose a system to analyze and predict influenza based on Arabic Twitter data. The proposed systems filters and extracts features from the Arabic tweets and classifies them into three categories; self-reporting, nonself-reporting and non-reporting. The classified tweets are then used to analyze the spread of Influenza in the UAE. Moreover, the classified tweets are used to predict the number of future hospitals visits by feeding the tweets into a linear regression model. The conducted evaluation show high correlation between the number of analyzed tweets and the number of hospital visits obtained from the Ministry of Health, UAE, which demonstrates the feasibility of the proposed system.
Synthesis of axially substituted gallium, indium and thallium phthalocyanines with nonlinear optical properties

Axially substituted phthalocyanines with gallium, indium and thallium as central coordinated atoms have been synthesized for nonlinear optical (NLO) studies. In particular, the optical limiting effect of 2(3)-tetrabuylphthalocyaninato indium chloride (1), hexadecachlorophthalocyaninato indium chloride (2), 2,3-octa-(2-ethyl-hexyloxy) phthalocyaninato gallium chloride (3a), 2,3-octa-(2-ethyl-hexyloxy)phthalocyaninato indium chloride (3b), 2,3-octa-(2-ethylhexyloxy)phthalocyaninato indium trifluoroacetate (4a), 2,3-octa-(2-ethyl-hexyloxy)phthalocyaninato thallium trifluoroacetate (4b), and 2,3,9,10,16,17-hexa-(2-ethyl-hexyloxy) monobenzophthalocyaninato indium chloride (5) has been evaluated and compared when the NLO regime was determined by nanosecond laser pulses in the visible spectrum. In the case of complexes 1 and 4a the determination of the excited state absorption cross section at 532 nm could be possible due the verification of reversible saturation of NLO absorption in the adopted experimental conditions. This allowed the use of the steady-state solutions for the kinetic equations describing sequential multiphoton absorption.
The afterglow mystery of pulsed glow discharges and the role of dissociative electron–ion recombination

It is generally recognized that excited level populations and, hence, optical emission intensities in pulsed glow discharges exhibit a peak upon pulse termination, i.e., in the so-called afterglow. This afterpeak formation is attributed in many papers to electron–ion recombination, but up to now this hypothesis could not be confirmed quantitatively by numerical modelling, because of too low electron and ion number densities and recombination rate coefficients. In the present paper, we show the calculation results of a model, which includes also Ar2+ ions, beside the Ar+ ions, and which takes into account the thermalization of the electrons upon pulse termination, yielding higher recombination rate coefficients. The role of electron–Ar2+ dissociative recombination and electron–Ar+ three-body recombination as afterpeak formation mechanisms is investigated. Our study clearly shows the important role of Ar2+ ions and dissociative recombination in the afterpeak formation in the afterglow of pulsed discharges.
Roles of B739_1343 in iron acquisition and pathogenesis in Riemerella anatipestifer CH-1 and evaluation of the RA-CH-1ΔB739_1343 mutant as an attenuated vaccine

Iron is one of the most important elements for bacterial survival and pathogenicity. The iron uptake mechanism of Riemerella anatipestifer (R. anatipestifer, RA), a major pathogen that causes septicemia and polyserositis in ducks, is largely unknown. Here, the functions of the putative TonB-dependent iron transporter of RA-CH-1, B739_1343, in iron utilization and pathogenicity were investigated. Under iron-starved conditions, the mutant strain RA-CH-1ΔB739_1343 exhibited more seriously impaired growth than the wild-type strain RA-CH-1, and the expression of B739_1343 in the mutant strain restored growth. qRT-PCR results showed that the transcription of B739_1343 was not regulated by iron conditions. In an animal model, the median lethal dose (LD50) of the mutant strain RA-CH-1ΔB739_1343 increased more than 104-fold (1.6×1012 CFU) compared to that of the wild-type strain RA-CH-1 (1.43×108 CFU). In a duck co-infection model, the mutant strain RA-CH-1ΔB739_1343 was outcompeted by the wild-type RA-CH-1 in the blood, liver and brain of infected ducks, indicating that B739_1343 is a virulence factor of RA-CH-1. Finally, immunization with live bacteria of the mutant strain RA-CH-1ΔB739_1343 protected 83.33% of ducks against a high-dose (100-fold LD50) challenge with the wild-type strain RA-CH-1, suggesting that the mutant strain RA-CH-1ΔB739_1343 could be further developed as a potential live attenuated vaccine candidate for the duck industry.
Transition-Based Chinese AMR Parsing

This paper presents the first AMR parser built on the Chinese AMR bank. By applying a transition-based AMR parsing framework to Chinese, we first investigate how well the transitions first designed for English AMR parsing generalize to Chinese and provide a comparative analysis between the transitions for English and Chinese. We then perform a detailed error analysis to identify the major challenges in Chinese AMR parsing that we hope will inform future research in this area.
Semantic tag recommendation based on associated words exploiting the interwiki links of Wikipedia

The volumes of multimedia content and users have increased on social multimedia sites due to the prevalence of smart mobile devices and digital cameras. It is common for users to take pictures and upload them to image-sharing websites using their smartphones. However, the tag characteristics deteriorate the quality of tag-based image retrieval and decrease the reliability of social multimedia sites. In this article, we propose a semantic tag recommendation technique exploiting associated words that are semantically similar or related to each other using the interwiki links of Wikipedia. First, we generate a word relationship graph after extracting meaningful words from each article in Wikipedia. The candidate words are then rearranged according to importance by applying a link-based ranking algorithm and then the top-k words are defined as the associated words for the article. When a user uploads an image, we collect visually similar images from a social image database. After propagating the proper tags from the collected images, we recommend associated words related to the candidate tags. Our experimental results show that the proposed method can improve the accuracy by up to 14% compared with other works and that exploiting associated words makes it possible to perform semantic tag recommendation.
The human side of big data: Understanding the skills of the data scientist in education and industry

It is widely recognized by public and private organizations, that the biggest challenge faced in light of the data revolution is finding people with the required set of skills to transform data into actionable insight. The growing interest on the role of the data scientist and the relating data analytics skills has seen an increasing amount of research on the importance of data analytics skills in the contemporary working environment. Yet, there is still limited understanding on the importance of data analytic skills, and even more, there is limited research on the discrepancies between the skills that are needed in the market and what graduates possess. To this end, this research uses a mixed-methods approach combining quantitative survey data from 113 IT executives, and qualitative interview data from 27 big data project managers to explore the significance, discrepancies, and aspects of data analytic skills. Our results show that data analytic skills significantly contribute firm performance, particularly for firms that are data-oriented. In addition, we find that the need for skills greatly exceeds those that graduates possess. Lastly, our analysis suggests that the data skills of the data scientist span multiple subject areas which are further discussed.
Seamless Multimedia Delivery Within a Heterogeneous Wireless Networks Environment: Are We There Yet?

The increasing popularity of live video streaming from mobile devices, such as Facebook Live, Instagram Stories, Snapchat, etc. pressurizes the network operators to increase the capacity of their networks. However, a simple increase in system capacity will not be enough without considering the provisioning of quality of experience (QoE) as the basis for network control, customer loyalty, and retention rate and thus increase in network operators revenue. As QoE is gaining strong momentum especially with increasing users’ quality expectations, the focus is now on proposing innovative solutions to enable QoE when delivering video content over heterogeneous wireless networks. In this context, this paper presents an overview of multimedia delivery solutions, identifies the problems and provides a comprehensive classification of related state-of-the-art approaches following three key directions: 1) adaptation; 2) energy efficiency; and 3) multipath content delivery. Discussions, challenges, and open issues on the seamless multimedia provisioning faced by the current and next generation of wireless networks are also provided.
Dataset : Corpus , Benchmarks and Metrics for Formality Style Transfer ( Supplementary Material )

In Section 3.2 of the main paper, we perform a qualitative analysis to understand the types of edits people made for making a sentence more formal. Table 1 shows the frequency of each types of edits and example sentence pairs for the same. In addition, for a subset of the categories for which we can count the edits automatically, we show the frequency of edits on the entire train split of our GYAFC dataset where we observe a higher percentage of capitalization and punctuation edits as compared to manual counting and a much higher percentage of normalizations.