Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of L-Cysteine and Acrylic Acid Imprinted Polypyrrole Sensors for Picomolar Detection of Lead Ions in Simple and Real Media

104 MHz surface acoustic wave sensors, functionalized with two polypyrrole (PPy) imprinted polymers, were designed for lead ion detection in liquid media. The main difference between the two ionic imprinted polymers (IIP) is related to the nature of the chelating agent: L-Cysteine (L-Cys) for the former and acrylic acid (AA) for the latter. Performances of the IIPs based sensors were compared in terms of sensitivity, limits of detection (LOD), dissociation constants and selectivity. The gravimetric results indicated that both designed sensors can detect picomolar concentrations of lead ions. These values are, in fact, significantly inferior to the World Health Organization (WHO) maximum accepted limit in drinking water, and among the lowest LODs ever reported in the literature. The relevant dissociation constants, calculated from the most appropriate fits of the calibration curves, were estimated at: Kd<inline-formula> <tex-math notation="LaTeX">$_{\textsf {1}} = (\textsf {1.1} \pm \textsf {0.4})\times \textsf {10}^{-\textsf {10}}$ </tex-math></inline-formula> M and Kd<inline-formula> <tex-math notation="LaTeX">$_{\textsf {2}}= (\textsf {1.1} \pm \textsf {0.8})\times \textsf {10}^{-\textsf {5}}$ </tex-math></inline-formula> M for L-Cys-IIP/Pb<sup>2+</sup> and Kd<inline-formula> <tex-math notation="LaTeX">$_{\textsf {1}}= (\textsf {1.1} \pm \textsf {0.3})\times \textsf {10}^{-\textsf {13}}$ </tex-math></inline-formula> M and Kd<inline-formula> <tex-math notation="LaTeX">$_{\textsf {2}}= (\textsf {5.9} \pm \textsf {1.8}) \times \textsf {10}^{-\textsf {10}}$ </tex-math></inline-formula> M for AA-PPy-IIP/ Pb<sup>2+</sup>, thus confirming the strong binding between the designed IIPs and lead ions. Selectivity tests were investigated with mercury, cadmium, copper, zinc, and nickel divalent ions, which largely coexist with lead ions in soils, rivers, and wastewaters.
Characterization, Identification and Phylogeny of the Cretaine Kinase (ckma) Gene in Medaka (Oryzias latipes)

Creatine kinase ( ckma ) has been characterized and described in the medaka ( Oryzias latipes ), an aquatic model organism and the gene structure has been designed using the exons, introns, produced amino acids of the gene, TATA box, poly A tail and 5’ UTR and 3’ UTR regions of the ckma gene. In another step, firstly, the chromosome region of the ckma gene was determined in medaka and then the other genes which placed in the same region were determined. Then the locations of these genes were determined in zebrafish and human which are the orthologs of medaka. Finally, the conserved gene synteny was designed manually, using these data. However, genetic identity and similarity ratio between medaka and its orthologs were calculated. In this study, characterization and identification, phylogenetic relationship, conserved gene synteny of ckma gene in medaka ( O. latipes ) which is an important model organism were analyzed by using bioinformatics tools (NCBI database, Ensembl genomic database, Expasy, Reverse Complementary and some programs such as MEGA6 program, BLOSUM62 matrix program and BioEdit software). All these data will be used in future studies on molecular stress response in fish and they were presented to the scientific world with this study.
P629 Long-term effectiveness and safety of ustekinumab (UST) in patients with active Crohn’s disease (CD) in real life: Interim analysis of the SUSTAIN study

Post-marketing data are required to confirm the durability and the long-term benefit and safety of UST in CD in clinical practice. Our aims were: (1) to evaluate the retention rate of UST in CD patients and to identify predictive factors of UST discontinuation; (2) to assess UST short-term effectiveness; (3) to analyse the durability of the response to UST in the long-term; and (4) to evaluate the safety of UST in clinical practice. Retrospective, multicentre study (>60 centres). Patients with active CD [(Harvey–Bradshaw (HBI) >4)] that received at least one dose of UST intravenously before July 2018 were included. Clinical activity plus biochemical parameters were assessed at every UST administration. Clinical remission was defined as HBI score ≤4, and clinical response as a decrease in HBI ≥3 points. Loss of efficacy was defined as reappearance of symptoms that led to intensify the treatment dose, add another medication to control CD, switching or surgery in patients with short-term remission. The retention rate of UST treatment and the cumulative incidence of loss of efficacy were evaluated by survival curves, and predictive factors were assessed by Cox-regression. The short-term response was evaluated at week 8 and after the induction (week 16). Factors associated with short-term remission were assessed by multivariate analysis. Adverse events were recorded. Data quality was assured by remote monitoring. 331 CD patients have been included up to date (Table 1). The incidence rate of UST discontinuation was 15% per patient-year of follow-up: 8%, 13% and 20% at 6, 12 and 18 months (Figure 1). Previous surgery was the only factor associated with a higher risk of UST discontinuation [Hazard ratio (HR) = 2.03, 95% confidence interval (CI) = 1.1–3.6]. Short-term efficacy is shown in Figure 2. Previous surgery (OR = 0.3, 95% CI = 0.2–0.6) and higher HBI score at baseline (OR = 0.8, 95% CI=0.8–0.9) were associated with an impaired response to UST at week 16. The cumulative incidence of loss of response was 32% per-patient-year of follow-up (Figure 3); A higher HBI score at baseline was associated with a higher risk of losing response (HR = 1.2, 95% CI = 1.1–1.3). Neither the concomitant treatment with immunosuppressants nor the number of previous biologics were associated with UST short- and long-term benefit. Thirty adverse events were reported in 25 (7%) patients (Table 2). Sustain is the largest real clinical practice study of UST to treat CD patients with the longest follow-up reported to date. UST was demonstrated to be effective in real-world use in the short and long run. Safety was consistent with the known profile of UST.
Rural Long Term Care Nurses’ Knowledge of Palliative Care

Purpose: Regardless of the location, rural nurses care for patients and their families across the trajectory of an illness and into death in long term care facilities. The purpose of this study was to examine rural nurses' knowledge of palliative care for end of life patients in long term care facilities. Method: A quantitative descriptive correlational design was utilized with a convenience sample of nurses (registered nurses and licensed practical nurses) in three rural long term care facilities in south-central Kentucky. Demographical data was utilized to describe the study subjects, and the Palliative Care Knowledge Test was utilized to measure the rural nurses' knowledge of palliative care. Descriptive statistics and Cross-tabs with a Chi-square test for independence were used for analysis . Findings: The rural nurses lacked knowledge of palliative care on the Palliative Care Knowledge Test. Although the study sample scored below 50%, registered nurses were more knowledgeable than licensed practical nurses on many of the items on the Palliative Care Knowledge Test. This study supports that the total years practiced in long term care does not affect the knowledge on the Palliative Care Knowledge Test. Registered nurses were more knowledgeable than licensed practical nurses on some items of the Palliative Care Knowledge Test. Conclusion: Nurses cannot practice what they do not know. Nurses who lack knowledge about the philosophy and principles of palliative care may lower the quality of end of life care for patients in long term care facilities. An evaluation of the knowledge level of nurses for palliative care is an important first step in instituting an educational intervention. Keywords : rural nurses, palliative care knowledge, and Palliative Care Knowledge Test DOI: http://dx.doi. org/10.14574/ojrnhc.v16i2. 409
Genomic differentiation among varieties of Iberian pig

Aim of study: The objective of this study was to identify the autosomal genomic regions associated with genetic differentiation between three commercial strains of Iberian pig.Area of study: Extremadura (Spain). Material and methods: We used the Porcine v2 BeadChip to genotype 349 individuals from three varieties of Iberian pig (EE, Entrepelado; RR, Retinto; and TT, Torbiscal) and their crosses. After standard filtering of the Single Nucleotide Polymorphism (SNP) markers, 47, 67, and 123 haplotypic phases from EE, RR, and TT origins were identified. The allelic frequencies of 31,180 SNP markers were used to calculate the fixation index (FST) that were averaged in sliding windows of 2Mb.Main results: The results confirmed the greater genetic closeness of the EE and RR varieties, and we were able to identify several genomic regions with a divergence greater than expected. The genes present in those genomic regions were used to perform an Overrepresentation Enrichment Analysis (ORA) for the Gene Ontology (GO) terms for biological process. The ORA indicated that several groups of biological processes were overrepresented: a large group involving morphogenesis and development, and others associated with neurogenesis, cellular responses, or metabolic processes. These results were reinforced by the presence of some genes within the genomic regions that had the highest genomic differentiation.Research highlights: The genomic differentiation among varieties of the Iberian pig is heterogeneous along the genome. The genomic regions with the highest differentiation contain an overrepresentation of genes related with morphogenesis and development, neurogenesis, cellular responses and metabolic processes.
The place of death among people with dementia in Finland - The change from 1998 to 2013

University of Tampere School of Health Sciences MASUCHI, YAEKO: THE PLACE OF DEATH AMONG PEOPLE WITH DEMENTIA IN FINLAND –THE CHANGE FROM 1998 TO 2013 Master’s Thesis, 63 pages, 2 Appendices Supervisors: Mari Aaltonen, Ph D, University of Tampere, Finland Health Sciences (Public Health) December 2016 Background: The prevalence of dementia has been expanding largely and quickly among the developed countries. The increasing prevalence of dementia is a significant problem, especially since there is currently no cure available for this disease. Dementia is the most prominent disease among older people associated with a loss of independent function and autonomy, which affects not only the patients but also their family members. Dementia becomes an important cause of disability and death worldwide. The quality of care toward and at the end of life care has discussed to be improved for benefits of not only people with dementia but also caregivers alongside the increasing prevalence of dementia in the older population. The place of death is suggested as a quality indicator for the end-of-life care. Finland is growing old most rapidly among EU countries. Details of the place of death for people with dementia in Finland have not been reported yet. Aims: The aim of this study was to reveal where people with dementia die in Finland, and what extent the frequency of different places of death has changed over time. Data: Data of the places of death of people with dementia were derived from Finnish national health and social care registers. Data covered all those who died at the age of over 70 years had dementia in the study years 1998 and 2002-2013, and a 40% random sample in the years 1999-2001 (N=140034). Methods and Results: Descriptive analysis and logistic regression analysis were done using the IBM SPSS statistics. During the study period, the frequency of dementia increased from 22% to 33.9%. Men with dementia died more often at an earlier age (aged 70-79) than women who died more frequently at a later age (aged 90+). During the study years 1998-2013, the most frequent place of death was the primary care hospital (i.e. the health center), followed by nursing home and sheltered housing with 24-hour assistance. Dying at home or specialized hospitals was rare. During the study years, dying in the hospital decreased. Dying in the long-term care facility increased. The sheltered housing with 24-hour assistance became a more frequent place of death in Finland. Conclusions: Trends in places of death has changed from institutional care to outpatient long-term care in Finland last decades. Death at home and specialized hospitals for people with dementia remained infrequent in Finland. Even nearly half of people with dementia died at the primary care hospital, but recently the trend of dying at long-term care facility, especially sheltered housing with 24-hour assistance increased in Finland.
Hierarchical Indian buffet neural networks for Bayesian continual learning

We place an Indian Buffet process (IBP) prior over the structure of a Bayesian Neural Network (BNN), thus allowing the complexity of the BNN to increase and decrease automatically. We further extend this model such that the prior on the structure of each hidden layer is shared globally across all layers, using a Hierarchical-IBP (H-IBP). We apply this model to the problem of resource allocation in Continual Learning (CL) where new tasks occur and the network requires extra resources. Our model uses online variational inference with reparameterisation of the Bernoulli and Beta distributions, which constitute the IBP and H-IBP priors. As we automatically learn the number of weights in each layer of the BNN, overfitting and underfitting problems are largely overcome. We show empirically that our approach offers a competitive edge over existing methods in CL.
Suitability of Shallow Water Solving Methods for GPU Acceleration

In the past 15 years the field of general purpose computing on graphics processing units, or GPUs, has become well developed and the practice is becoming more mainstream. Computational demands of simulation software are continuously increasing. As such for many applications traditionally computed on the central processing unit the question arises of whether moving to GPU computing is a possible cost effective way of meeting these demands. The fundamental nature of GPU architecture that makes it so cost effective at doing bulk computation also poses restrictions on which applications are suitable for it. The shallow water equations are a simplified form of the Navier-Stokes equations and describe water levels and flow currents in suitably shallow water such as rivers, estuaries and the North sea. The main research goal of this thesis project was to determine whether the shallow water equations are suitable for implementation on a GPU. Two options exist, the equations may be solved with either an explicit or implicit time integration method. First, a literature study was conducted to familiarize with the tools required to build explicit and implicit shallow water models on a GPU. Then both an explicit and implicit shallow water solver were developed first in the MATLAB programming language and later in CUDA C++ on both CPU and GPU. The main findings are that both explicit and implicit methods are well suited for GPU implementation. Both methods proved to be compatible with a wetting and drying mechanism of numerical cells. The Cuda C++ implementation was in the order of 10 times as fast as a MATLAB implementation for both CPU and GPU. For the benchmark cases tested, the Cuda C++ GPU implementation was in the order of 50 times faster than the equivalent multithreaded CPU implementation. The implicit implementation was benchmarked using the conjugate gradient method to solve the linear system. Various preconditioners were tested and a Repeated Red Black preconditioner was found to be the most effective. The computation time of the RRB preconditioned implicit method was compared with the explicit method and it was found that the two methods reached parity in computation time when the implicit time step was taken roughly 50 times as large as the explicit time step. For implicit time steps smaller than that the explicit method was faster and when the implicit time step was larger the implicit method was faster. For the benchmark cases tested, the implicit method using a time step 50 times larger than the explicit method was found to be less accurate and less stable than the explicit method. The conclusion is that for cases similar to the benchmark cases an explicit method is the fastest, most stable and most accurate method and thus the preferred choice.
Enterprise Architecture Planning Using TOGAF-ADM at Scoob Telur Company

Scoob Telur is a company that operates in the distribution of eggs in the Province of East Java, especially in the capital city of Surabaya. Unfortunately, business processes ranging from sales, expenses and report generation are still not supported by the use of IS / IT and the absence of strategic information systems planning or mature enterprise architecture. Besides, based on the results of observations and interviews, it was found that there is no information system that can manage financial processes systematically and there are no applications that can help the company's business processes. Based on these, an information system and information technology are needed that can be used to manage the financial process and also control and monitor the company so that it can advance the performance and service of the Scoob Telur company. Enterprise architecture design uses TOGAF ADM, which is a detailed framework used to design, evaluate and build architecture enterprise. The results of this research provide a design that determines business architecture, data architecture, application architecture, technology architecture, and opportunities and solutions and also includes application system design proposals so that it can support business processes as well as making reports that occur on Scoob Telur.
Double and Triple Node-Erasure-Correcting Codes Over Complete Graphs

In this paper we study array-based codes over graphs for correcting multiple node failures. These codes have applications to neural networks, associative memories, and distributed storage systems. We assume that the information is stored on the edges of a complete undirected graph and a <italic>node failure</italic> is the event where all the edges in the neighborhood of a given node have been erased. A code over graphs is called <inline-formula> <tex-math notation="LaTeX">$\rho $ </tex-math></inline-formula><italic>-node-erasure-correcting</italic> if it allows to reconstruct the erased edges upon the failure of any <inline-formula> <tex-math notation="LaTeX">$\rho $ </tex-math></inline-formula> nodes or less. We present a binary optimal construction for double-node-erasure correction together with an efficient decoding algorithm, when the number of nodes is a prime number. Furthermore, we extend this construction for triple-node-erasure-correcting codes when the number of nodes is a prime number and two is a primitive element in <inline-formula> <tex-math notation="LaTeX">$\mathbb {Z}_{n}$ </tex-math></inline-formula>. These codes are at most a single bit away from optimality.
Vacuum Structure of Models beyond the Standard Model

Mit der Messung des Higgs-Bosons im Jahr 2012 wurde das letzte Elementarteilchen des Stan- dardmodells der Teilchenphysik gefunden. Obwohl dessen Vorhersagen kompatibel mit den Messungen an Teilchenbeschleuniger-Experimenten sind, gibt es noch viele offene Fragen, die vom Standardmodell der Teilchenphysik nicht beantwortet werden konnen. Zu diesen Fragen gehoren unter anderem die Stabilitat des Vakuums bei hohen Energien oder die gemessene Asymmetrie zwischen Materie und Antimaterie im Universum. Um diese beiden Fragen mit den Ergebnissen von Teilchenbeschleuniger-Experimenten zu kombinieren, werden ver- schiedene Theorien mit Physik jenseits des Standardmodells der Teilchenphysik untersucht. In dieser Arbeit werden hierfur das Zwei-Higgs-Dublett Modell, sowohl in seiner ladungs- und paritatserhaltenden als auch verletzenden Variante, und das Nichtminimale Zwei-Higgs- Dublett Modell als konkrete Modelle fur die Erweiterung des Higgs Potentials des Standard- modells untersucht. Fur beide Varianten des Zwei-Higgs-Dublett Modells wird die Stabilitat des Vakuums bei hohen Energien berechnet. Eine wichtige Komponente fur die Asymmetrie zwischen Materie und Antimaterie im Universum und andere Effekte im fruhen Universum ist der elektroschwache Phasenubergang. Wahrend dieser Arbeit wurde hierfur der C++ Code BSMPT entwickelt und veroffentlicht, welcher die numerische Berechnung der Starke des elektroschwachen Phasenubergangs ermoglicht. Durch den modularen Aufbau konnen neue Modelle fur Physik jenseits des Standardmodells in BSMPT implementiert werden. Diese Arbeit zeigt den Effekt, den die Forderung eines elektroschwachen Phasenubergangs starker erster Ordnung auf den moglichen Parameterraum beider Modelle hat. Da das ladungs- und par- itatsverletzende Zwei-Higgs-Dublett Modell alle notwendigen Bausteine fur Entstehung einer Asymmetrie zwischen Materie und Antimaterie zur Verfugung stellt, wurde diese wahrendx dieser Arbeit ausgerechnet. Diese Rechnungen werden abschliesend mit den Ergebnissen aktueller Teilchenbeschleuniger-Experimente kombiniert und der Effekt auf den moglichen Parameterraum des Modells dargestellt.
The Dynamics of (De)Stigmatization: Boundary construction in the nascent category of organic farming

This study finds that it is possible for organizations in emerging categories to resist stigmatization through discursive reconstruction of the central and distinctive characteristics of the category in question. We examined the emerging market of organic farming in Finland and discovered how resistance to stigmatization was both an internal and an external power struggle in the organic farming community. Over time, the label of organic farming was manipulated and the practice of farming was associated with more conventional and familiar contexts, while the stigma was diverted at the same time to biodynamic farming. We develop a process model for removal of stigma from a nascent category through stigma diversion. We find that stigma diversion forces the core community to (re)define themselves in relation to the excluded community and the mainstream. We also discuss how notoriety can be an individuating phenomenon that helps categorical members conduct identity work and contributes to stigma removal.