Miracle-dz/UniFAR-FTUs huggingface dataset:
PHYSICO-CHEMICAL, SENSORY AND ANTI-OXIDANT ACTIVITY OF HERBAL EXTRACT ON KHOA PREPARED FROM COW MILK

A study was undertaken to assess the effect of betel leaves (Piper betel Linn) extract on the physico-chemical, sensory and antioxidant properties of khoa made from cow’s milk and stored under room temperature. The physico-chemical parameters viz., pH, titratable acidity, fat, free fatty acids, sensory and antioxidant properties were evaluated periodically at an interval of 3 days upto 9 days. The result revealed that sensory evaluation of khoa was not influenced by the presence of 0.5 per cent aqueous extract of betel leaves up to 9 days of storage period with an overall acceptability score of 6.83. The physico- chemical properties of khoa showed an increasing trend in acidity and decrease of pH as the storage period progresses. The free fatty acids levels were well within the prescribed limit because of antioxidant properties exhibited by the aqueous extract of betel leaves. From the study, it was concluded that khoa with 0.5 aqueous extract of betel leaves restricted the free fatty acid compared to control due to antioxidant property of betel leaves.
of outcomes for off-pump versus on-pump coronary artery bypass grafting in low-volume and high-volume centers and by low-volume

Background: Few centres and cardiac surgeons in the U.S. perform enough off-pump coronary artery bypass (OPCAB) procedures to be co nsidered ‘‘specialists’’ . The clinical implications of this observation remain unclear. We investigated whether the volume of OPCAB procedures by hospital and individual surgeon influenced patient outcomes when compared with on pump coronary artery bypass (ONCAB) surgery. Methods: A total of 546,243 OPCAB (26.1%) and 1,547,851 ONCAB (73.9%) procedures performed from 2003 to 2011 and collected in the US Nationwide Inpatient Sample were included in the analysis. Hierarchical logistic regression models were used to compared OPCAB and ONCAB in the whole population and across OPCAB volume quartile groups to investigate the effect of hospital and surgeon procedures volume on early in hospital mortality. Results: In patients requiring 2 or more grafts , OPCAB compared with ONCAB was associated with increased risk-adjusted mortality when performed in low volume centres (<29 cases/year) (OR; 1.32;95%CI 1.06-1.57) or by low volume surgeons (<19 cases/year) (OR 1.26; 95%CI 1.02- 1.56). In high OPCAB volume centres (≥164 cases/year) and surgeons (≥48 cases/year), OPCAB reduced mortality compared with ONCAB in cases requiring a single graft (OR 0.66; 95%CI 0.49-0.89 and OR 0.33; 95%CI 0.22-0.47) or 2 or more grafts (OR 0.82; 9%%CI0.66- 0.99 and OR 0.63; 95%CI 0.49- 0.81). Conclusions: OPCAB surgery in high volume hospitals and surgeons reduces mortality compared to ONCAB surgery. OPCAB surgery by low volume centres and surgeons should be discouraged.
Reﬂective Practice in Times of Covid-19: A Tool to Improve Education for Sustainable Development in Pre-Service Teacher Training

: Crisis situations such as the current Covid-19 pandemic are a catalyst for change. This study stresses the need to work towards achieving quality education, and to prepare future teachers in sustainability competencies. The research questions are related to the key competencies necessary to accelerate change and to how to increase awareness and literacy of the SDGs in higher education. A quantitative methodology aimed at improving the training of future teachers who engage in reﬂective and critical thinking was used. Data were gathered on the level of reﬂection of students from three Spanish universities. The instrument used, the Reﬂective Practice Questionnaire, includes concepts deﬁned in the literature related to reﬂective capacity such as Reﬂection in Action, Reﬂection on Action and Reﬂection with Others. The results of the study provide quantitative data showing a positive impact of reﬂective practice on future teachers. Education for sustainable development requires participatory methods that motivate and empower students to change their behaviour. Reﬂective practice must be accompanied by processes of communication and supervision that encourage conﬁdence and the desire to improve. Training future teachers in reﬂective practice should be a differentiating element to achieve quality education, allowing adaptation to current and future adverse situations.
Prognostic signi cance of occult lymph node metastases in breast cancer: a meta-analysis

Guixin Wang General Surgery Department, Dalian University A liated Xinhua Hospital Shuhao Zhang Cardiology Department, The First Hospital of Qinhuangdao Meiling Wang Breast Surgery Department, The Second Hospital of Dalian Medical University Lin Liu General Surgery Department, Dalian University A liated Xinhua Hospital Yaqian Liu Breast Surgery Department, The Second Hospital of Dalian Medical University Lianjun Tang General Surgery Department, Dalian Jinzhou First People's Hospital He Bai General Surgery Department, Dalian University A liated Xinhua Hospital Haidong Zhao (  617410555@qq.com ) Breast Surgery Department, The Second Hospital of Dalian Medical University
CEOR_A_312523 553..564

1Danish Center for Health Care Improvements, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 2Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark; 3Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Purpose: To evaluate the cost-effectiveness of long-term domiciliary high flow nasal cannula (HFNC) treatment in COPD patients with chronic respiratory failure. Patients and Methods: A cohort of 200 COPD patients were equally randomized into usual care ± HFNC and followed for 12 months. The outcome of the analysis was the incremental cost per quality-adjusted life-year (QALY) gained, and the analysis was conducted from a healthcare sector perspective. Data on the patients’ health-related quality of life (HRQoL), gathered throughout the trial using the St. George’s Respiratory Questionnaire (SGRQ), was converted into EQ-5D-3L health state utility values. Costs were estimated using Danish registers and valued in British pounds (£) at price level 2019. Scenario analyses and probabilistic sensitivity analyses were conducted to assess the uncertainty of the results. Results: The adjusted mean difference in QALYs between the HFNC group and the control group was 0.059 (95% CI: 0.017; 0.101), and the adjusted mean difference in total costs was £212 (95% CI: −1572; 1995). The analysis resulted in an incremental cost-effectiveness ratio (ICER) of £3605 per QALY gained. At threshold values of £20.000–30.000 per QALY gained, the intervention had an 83–92% probability of being cost-effective. The scenario analyses all revealed ICERs below the set threshold value and demonstrated the robustness of the main result. Conclusion: This is the first cost-effectiveness study on domiciliary HFNC in Europe. The findings demonstrate that long-term domiciliary HFNC treatment is very likely to be a costeffective addition to usual care for COPD patients with chronic respiratory failure. The results must be interpreted in light of the uncertainty associated with the indirect estimation of health state utilities.
A new vision of the inert doublet model of dark matter

The Inert Doublet Model (IDM) is a simple and yet very rich extension of the Standard Model which provides interresting scalar dark matter candidates. In these proceedings, we show that annihilation into 3 body final states WW * → ff′, overlooked in all the previous studies devoted to this model, can significantly affect the viable parameter space of the IDM as well as the prospects for direct and indirect detection searches. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.
BULANIK TOPSIS YÖNTEMİYLE TEDARİKÇİ SEÇİMİ

Tedarik zinciri yonetiminin onemli bir halkasini olu turan tedarikci secimi, isletmelerin aldigi stratejik kararlardan biridir. Bu calismanin amaci, bir gida isletmesindeki karar vericilerle yapilan mulakatlar sonucu elde edilen bilgilerden hareketle, belirsizlik ortaminda, isletme icin uygun olan tedarikci kriterlerini goz onune alarak, alternatifler arasindan yapilacak tedarikci secimini bulanik CKKV yontemlerinden biri olan bulanik TOPSIS yontemi ile gerceklestirmektir. Bulanik TOPSIS yontemi ideal cozumun, bulanik pozitif ideal cozume en yakin ve bulanik negatif ideal cozumden en uzak mesafede olmasi prensibine dayanir. Yontemin uygulamasinda uc karar verici once tedarikci seciminde dikkate alinacak olan alti karar kriterinin onem agirliklarini belirlemekte, sonra da bu karar kriterlerine gore dort tedarikci alternatifini dilsel degiskenlerle degerlendirmektedirler. Bu degerlendirmeler daha sonra ucgen bulanik sayilara donusturulerek ve bulanik TOPSIS yonteminin adimlari uygulanarak, alternatifler icin sonucta hesaplanan yakinlik katsayilarina gore tercih siralamasi olusturulmaktadir. Boylece, isletmelere bircok acidan avantaj saglayan, bilimsel ve kolay uygulanabilir bir yontem olan bulanik TOPSIS yontemi kullanilarak, tedarikci secimi icin bulanik ortamlarda grup karari alinabilecegi gosterilmektedir.
Linear temporal stability analysis

An infinite flat plate covered with a thin layer of a power-law fluid sheared by an air stream is considered. The equations and boundary conditions governing the temporal linear stability problem are derived assuming small disturbances superimposed on a steady primary flow. The latter consists of a Blasius boundary-layer flow for the air stream and an exact solution of the Navier-Stokes equations for the thin fluid layer. Sources of change in kinematic energy and enstrophy are identified. A spectral collocation method based on Chebyshev polynomials is implemented and the resulting algebraic problem is solved using a QZ-algorithm. An isolated Blasius boundary-layer flow showed instability above a critical Reynolds number (approx. 300) for a range of wave numbers (Blasius mode). The presence of a thin fluid layer introduced, next to the (hardly changed) Blasius mode, an additional unstable mode (interfacial mode) exhibiting smaller amplification rates and a larger range of instability. The Blasius mode instability is driven mainly by the Reynolds stress and the interfacial mode by the action of viscosity. This research has been carried out within the framework of predicting the dynamic behaviour of a thin layer of liquid (e.g. water or anti-icing fluid) sheared by an air flow.
Gene Segment Transcription and Rearrangement Before Surface Expression of the Pan-B – Cell Marker CD 19 in Normal Human Bone Marrow

ing characteristic of the progenitor population in which Bcontaining DJCm transcripts were detected in both fetal and lineage commitment occurs. These features were used to adult cells. Although DHQ52 DJCm transcripts were abundant better define the earliest stage of B-cell commitment in huin fetal CD34 CD19 cells, they were not detected in cells mans and to determine if these stages differ as a function of the same phenotype derived from adult bone marrow. In of human ontogeny. Fetal and adult bone marrow mononuboth fetus and adult, VH3-and VH6-containing VDJCm tranclear cells were sorted into B-lineage subpopulations on the scripts were detected only in the CD19 subpopulations. basis of surface expression of the stem cell marker CD34, These data indicate that transcription of DHQ52-JH and DXPthe pan-B–cell marker CD19, and IgM and analyzed for tranJH rearrangements differs during fetal and adult B lymphoscription and rearrangement of the IgH locus. The locus was poiesis. Moreover, in both fetus and adult, transcription of found to be transcriptionally active before surface expresunrearranged components of the IgH locus and DJ rearsion of CD19, as indicated by the presence of germline Im, rangements can proceed before the surface expression of Cm, and DHQ52 transcripts in the CD34 CD19 subpopulaCD19. tion. Transcripts from IgH alleles that had undergone DJCm q 1997 by The American Society of Hematology. rearrangements were also detected in the CD34CD19 sub-
A Representational Framework for Spatial Design Based on Constraint-Oriented Fuzzy Logic

—In this paper, we propose a novel framework for representing “design patterns,” which are composition of artiﬁcial environments. Our framework extracts ecological factors of artiﬁcial environments from design examples. Focusing on indoor spatial designs, we take data using the traditional hill climbing algorithm on physical appearances of a certain architectural space. The data are organized into some clusters that are translated into Constraint-Interval Fuzzy Set (CoIFS). By using CoIFS, we can implement human-centered measurements. The design pattern is represented by both CoIFSs and contiguity among them. We discuss on the validity of our framework with a computational simulation. Extracted design patterns by our framework are instantiated into environmental factors of another design.
Identification of (high-redshift) AGN with WFXT: lessons from COSMOS and CDFS

The Wide Field X-ray Telescope (WFXT) will provide tens of millions of AGN, with more than 4x10^5 expected at z>3. Here we review the issues present in the identification of (large) samples of faint and high-redshift X-ray sources, and describe a statistical, powerful tool that can be applied to WFXT catalogs. The depth of associated optical and near infrared catalogs, needed for a reliable and as much complete as possible identification, are also discussed, along with the combined synergies with existing or planned facilities
Cumulative Febrile, Respiratory, and Diarrheal Illness among Infants in Rural Guatemala and their Association with Neurodevelopmental and Growth Outcomes.

Objective: We aimed to evaluate the association between cumulative illness with neurodevelopment and growth outcomes in a birth cohort of Guatemalan infants. Study Design: From June 2017 to July 2018, infants 0-3 months of age living in a resource-limited region of rural southwest Guatemala were enrolled and completed weekly at-home surveillance for caregiver-reported cough, fever and vomiting/diarrhea. They also underwent anthropometric assessments and neurodevelopmental testing with the Mullen Scales of Early Learning (MSEL) at enrollment, six months, and one year. Results: Out of 499 enrolled infants, 430 (86.2%) completed all study procedures and were included in the analysis. At 12-15 months of age, 140 (32.6%) infants had stunting (length-for-age Z [LAZ] score <-2 SD) and 72 (16.7%) had microcephaly (occipital-frontal circumference [OFC] <-2 SD of the mean). In multivariable analysis, greater cumulative weeks of reported cough illness (beta=-0.08/illness-week, p=0.06) and febrile illness (beta=-0.36/illness-week, p<0.001) were marginally or significantly associated with lower MSEL Early Learning Composite (ELC) Score at 12-15 months, respectively; there was no association with any illness (cough, fever, and/or vomiting/diarrhea; p=0.27) or with cumulative weeks of diarrheal/vomiting illness alone (p=0.66). No association was shown between cumulative weeks of illness and stunting or microcephaly at 12-15 months. Conclusions: These findings highlight the negative cumulative consequences of frequent febrile and respiratory illness on neurodevelopment during infancy. Future studies should explore the inflammatory profile associated with these syndromic illnesses and their impact on neurodevelopment in the first years of life.
Discussion on Lechicki and Spakowski's counterexample

It is well-known that intersection of continuous correspondences can lost the continuity property. Lechicki and Spakowski's theorem says that intersection of H-lsc functions remains H-lsc if the intersection is a bounded subset of a normed space and its interior is nonempty. Lechicki and Spakowski pointed to the importance of the boundedness assumption in the case of infinite dimensional range giving a counterexample. Even though the counterexample works properly and is one of the most cited patterns of discontinuity, it has no detailed discussion in the literature of economics and optimization theory. What is more, some misleading interpretation of this very important counterexample can be observed. Our technical note clarifies the exact role of Lechicki and Spakowski's counterexample, computing each of the important properties of the correspondences rigorously.
Galileo, Bernoulli, Leibniz and Newton around the brachistochrone problem

The brachistochrone problem, having challenged the talents of Newton, Leibniz and many others, plays a central role in the history of physics. Their solutions not only give implicit information as to their mathematieal skills and cleverness, but also are worthwhile beeause oí their heuristic contento \Ve emphasize several physical and mathematical details around this problem, reviewing for this the geometrical and mechanical methods of Huygens applied to the cycloid. The solutions of Leibniz and Bernoulli are presented, followed by Newton 's Theorem on cycloids and his solution sent to Charles Montague. A geometrical approach to this problem, as counterexample against the contention of Leibniz that it may only be solved through the mastering of 'his' calculus, is given. Dnder the light of such solutions and of the historical frame, we discuss how Galileo was involved, with this problem, into the priority dispute between Newton and Leibniz. RESUMEl'<. El problema de la braquist6crona, habiendo retado los ingenios de Newton, Leibniz y muchos otros, juega un papel central en la historia de la física. Las soluciones con que aquellos respondieron al reto no sólo dan información implícita respecto de sus talentos matemáticos y astucia, sino que también resultan de gran valor por su contenido heurístico. Resaltamos algunos detalles físico-matemáticos alrededor de este problema, repasando los métodos geométricomecánicos de Huygens, relativos a la cicloide. Se presentan las soluciones de Leibniz y Dernoulli, seguidas de un teorema de Newton relativo a la cicloide, y de la solución que envió a Charles Montague. Se brinda una solución geométrica de este problema, en calidad de ejemplo, contra la aseveración de Leibniz de que este problema sólo puede ser resuelto mediante el dominio de su cálculo. A la luz de tales soluciones y del marco histórico, analizarnos como fue involucrado Galileo, mediante este problema, en la controversia sobre la paternidad del cálculo entre Newton y Leibniz. PACS: 0J.65. +G; 02.40. -k; 03.20. +i
Preconditioning the Lasso for sign consistency

: Sign consistency of the Lasso requires the stringent irrepre- sentable condition. This paper examines whether preconditioning can circumvent this condition. Let X ∈ R n × p and Y ∈ R n satisfy the standard linear regression equation. Instead of computing the Lasso with ( X ,Y ), preconditioning ﬁrst left multiplies by F ∈ R n × n and then computes the Lasso with ( F X ,FY ). While others have proposed preconditioning for other purposes, we provide the ﬁrst results that show F X can satisfy the irrepresentable condi- tion even when X fails to satisfy the condition. Preconditioning the Lasso creates a new estimator that is sign consistent in a wider variety of set- tings. Importantly, left multiplying the regression equation by F does not change β , the vector of unknown coeﬃcients. However, left multiplying this equation by F often inﬂates the variance of the errors. We propose a class of preconditioners to balance these costs and beneﬁts.
Numerical Methods for Portfolio Risk Estimation

In portfolio risk management, a global covariance matrix forecast often needs to be adjusted by changing diagonal blocks corresponding to specific sub-markets. Unless certain constraints are obeyed, this can result in the loss of positive definiteness of the global matrix. Imposing the proper constraints while minimizing the disturbance of off-diagonal blocks leads to a non-convex optimization problem in numerical linear algebra called the Weighted Orthogonal Procrustes Problem. We analyze and compare two local minimizing algorithms and offer an algorithm for global minimization. Our methods are faster and more effective than current numerical methods for covariance matrix revision.
Initiating dopamine agonists rather than levodopa in early Parkinson's disease does not delay the need for deep brain stimulation

While levodopa is the most effective symptomatic treatment for Parkinson's disease (PD), its use is associated with an increased risk of motor complications (MCs) in the first 5 years of treatment compared to dopamine agonist (DA) first therapy. It is not known whether this translates into true benefit later in the disease. We aimed to determine whether there is a difference in the time between initial levodopa versus DA treatment and the development of disabling MCs prompting deep brain stimulation (DBS) consideration.
Phenomenological Aspects of Theories for Baryon and Lepton Number Violation

The renormalizable couplings of the Standard Model are invariant under two accidental global symmetries, which correspond to conserved baryon and lepton numbers. In this thesis, we discuss possible roles of these symmetries in extension of the Standard Model. Two approaches are considered: explicit violation of lepton number by two units in the renormalizable couplings of the Lagrangian, and promotion of the global symmetries to local gauge symmetries that are spontaneously broken. The former approach directly leads to Majorana neutrino masses and neutrinoless double beta decay. We discuss the interplay of the contributions to this decay in a one-loop neutrino mass model, the colored seesaw mechanism. We find that, depending on the parameters of the model, both the light Majorana neutrino exchange and the contribution of the new colored particles may be dominant. Additionally, an experimental test is presented, which allows for a discrimination of neutrinoless double beta decay from unknown nuclear background using only one isotope. In the latter approach, fascinating implications originate from the attempt to write down an anomaly-free and spontaneously broken gauge theory for baryon and lepton numbers, such as an automatically stable dark matter candidate. When gauging the symmetries in a left–right symmetric setup, the same fields that allow for an anomaly-free theory generate neutrino masses via the type III seesaw mechanism.
Particle Acceleration in Solar Flares and Escape Into Interplanetary Space

We review the physics of particle acceleration and kinematics in solar flares under the particular aspect of their escape and propagation into interplanetary space. The topics include the magnetic topology in acceleration regions, the altitude of flare acceleration regions, evidence for bi-directional acceleration, the asymmetry of upward versus downward acceleration, and particle access to interplanetary space.
Integrated PPI- and WGCNA-retrieval of hub gene signatures for soft substrates inhibition of human fibroblasts proliferation and differentiation

Fibroblasts (FBs) are the most important functional cells in the process of wound repair, and their functions can be activated by different signals at the pathological site. Although wound repair is associated with microenvironmental stiffness, the effect of matrix stiffness on FBs remains elusive. In this study, TGF-β1 was used to mimic the fibrotic environment under pathological conditions. We found that the soft substrates made FBs slender compared with tissue culture plastic, and the main altered biological function was the inhibition of proliferation and differentiation ability. Through PPI and WGCNA analysis, 63 hub genes were found, including GADD45A, CDKN3, HIST2H3PS2, ACTB, etc., which may be the main targets of soft substrates affecting the proliferation and differentiation of FBs. Our findings not only provide a more detailed report on the effect of matrix stiffness on the function of human skin FBs, but also may provide new intervention ideas for improving scars and other diseases caused by excessive cell proliferation, with potential clinical application prospects.