Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Suitability and Potential of Nursing Care Discussion Forums as a Health Promotion Measure for Long-Distance Caregiving Relatives: Evidence from Upper Austria

Background: The number of persons who have to overcome extensive geographical distances for caring for their older parent(s), hereinafter referred to as long-distance caregiving relatives (LDCs), is rising. However, in the non-English-speaking Global North, little is known about the LDCs’ health literacy and the design of tailor-made health promotion measures for this target-group. Using the example of nursing care discussion forums (NCDF), this paper reflects the requirements and (future) potential of professionally-lead support groups for LDCs on the case-study example of Upper Austria. Methods: In order to approach this unexplored topic considering spatial-related aspects, a qualitative-explorative study design was chosen, focusing on the providers’ perspective. A written survey among all NCDF-group leaders was carried out. Results: LDCs do not make use of NCDFs at present. It is considered that this is above all for time constraints, lack of information and location-based problems of fit. This applies for urban as well as rural contexts. Conclusions: LDCs need more attention in public health. Suitable NCDFs have to be located in the LCDs’ residential municipalities and have to fulfill different requirements from those of local caregiving relatives, particularly with regard to purpose and scope.
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

In this study, Labi et al. examined the role of miRNAs in suppressing apoptosis by targeting miRNA-17~92 involved in regulating the pro-apoptotic protein BIM. Through conditional seed match mutagenesis the authors show that blocking miR-17~92:Bim interaction early in development phenocopied the lethal lung phenotype, produced a selective inability of B cells to resist cellular stress, and prevented B and T cell hyperplasia caused by Bim haploinsufficiency.
Research article PRE-CLINICAL SCREENING OF INDIGENOUS MEDICINAL PLANT PHYLLANTHUS AMARUS FOR ITS ANALGESIC ACTIVITY

Background: Phyllanthus amarus aqueous extract was investigated for its central and peripheral analgesic activities. Objectives: To evaluate the central and peripheral analgesic activities of aqueous extract of Phyllanthus amarus. Materials and Methods: The aqueous extract of Phyllanthus amarus was prepared using soxhlet apparatus. An in vivo study using Swiss albino mice was done to screen the central and peripheral analgesic activity of P.amarus extract. The extract was administered at a dose of 100 mg/kg body weight I.P. The peripheral analgesic activity was assessed using acetic acid induced writhing test.The central analgesic activity was assessed using Eddy's hot plate apparatus. Results: The aqueous extract of P.amarus showed significant (p<0.05) peripheral and central analgesic activity.Conclusion: This study demonstrated that P.amarus aqueous extract exhibited significant analgesic activities.
Reaction Time Measurement in Different Periods of Shift Work at Nurses

Shift work is associated with increased risk of health problems. We chose to test the parameters of wakefulness at shift-working nurses using the Performance Vigilance Task (PVT-192). The visual analogue scale of sleepiness (VAS) and selected sleep history data were included in the investigation. 20 nurses working in a 12-hour rotating shift regimen were included. Exclusion criteria comprised the use of sleep-modulating drugs, the presence of history-based sleep disorders, morbidity. Each of the nurses underwent a total of four PVT tests, before and then after her (day or night) duty. The reaction time (RT) mean value before the day shift was 261.3ms (SD±38.7), after the day shift 260.1ms (SD±33.1), before the night shift 251.3ms (SD±23.5), after the night shift 260.5ms (SD±26.1). There were significant differences in RT before and after the night duty, and between the RT of both evening measurements. The difference in RT before and after duty was significantly greater after night shifts. There was a significant difference between the rate of PVT test errors before the day shift and after the night shift. VAS-based subjective rating of daytime sleepiness was 3.3 (SD±2.2) before and 3.5 (SD±2.8) after the day shift, 3.1 (SD±2.4) before and 5.9 (SD±2.3) after the night shift. There was a significant difference between VAS before and after night shifts, and a significant difference in the VAS difference between the beginning and end of the night shift in comparison with the day shift. Clearly enough, the circadian aspect has a major role to play in the testing.
Validation of Cardiac Output as Reported by a Permanently Implanted Wireless Sensor

The CardioMEMS heart failure (HF) system was tested for cardiac output (CO) measurement accuracy using an in vitro mock circulatory system. A software algorithm calculates CO based on analysis of the pressure waveform as measured from the pulmonary artery, where the CardioMEMS system resides. Calculated CO was compared to that from reference flow probe in the circulatory system model. CO measurements were compared over a clinically relevant range of stroke volumes and heart rates with normal, pulmonary hypertension (PH), decompensated left heart failure (DLHF), and combined DHLF + PH hemodynamic conditions. The CardioMEMS CO exhibited minimal fixed and proportional bias.
The minimal effective dose of spinal hyperbaric bupivacaine for successful reliable saddle block for minor perianal surgeries

Objective The aim of this study was to determine the minimal effective dose of spinal hyperbaric bupivacaine required to induce a reliable and satisfactory saddle block for perianal surgeries (using a modified Dixon′s up-and-down method). Materials and methods A total of 24 adult patients scheduled for perianal surgeries were enrolled in this study. Dural puncture was performed using a standard midline approach in the sitting position at the L3-L4 intervertebral space, using a 25 G Whitacre needle with its orifice directed caudal. A small quantity (1.5 mg) of hyperbaric bupivacaine was injected. All patients remained in the sitting position for 10 min immediately before and after surgery; the block was tested using a long surgical toothless clamp and modified Bromage scale. A successful block was defined as one that was sufficient to proceed with the surgery without any supplementation. The dose of bupivacaine given to the next patient was guided by modified Dixon′s up-and-down method using 0.5 mg as a step size. Patients′ ability to position themselves, ambulation time, time of hospital discharge, patient and surgeon satisfaction, and any intraoperative or postoperative complication were recorded. The minimal effective dose of hyperbaric bupivacaine for successful saddle block for 50% (ED 50 ) of patients was determined by calculating the midpoint dose of all independent pairs of patients after at least seven crossover points. Results The ED 50 of hyperbaric bupivacaine for successful saddle block for perianal surgeries was 1.9 mg (95% confidence interval = 1.7-2.1 mg). There were zero motor blockade, early ambulation, short time to void, and early hospital discharge, as well as no complications and excellent patient and surgeon satisfaction. Conclusion The ED 50 of spinal hyperbaric bupivacaine for saddle block for perianal surgery is 1.9 mg (95% confidence interval = 1.7-2.1 mg). This block is reliable and has short duration, no complication, and excellent patient and surgeon satisfaction.
μDBSCAN: An Exact Scalable DBSCAN Algorithm for Big Data Exploiting Spatial Locality

DBSCAN is one of the most popular and effective clustering algorithms that is capable of identifying arbitrary-shaped clusters and noise efficiently. However, its super-linear complexity makes it infeasible for applications involving clustering of Big Data. A major portion of the computation time of DBSCAN is taken up by the neighborhood queries, which becomes a bottleneck to its performance. We address this issue in our proposed micro-cluster based DBSCAN algorithm, μDBSCAN, which identifies core-points even without performing neighbourhood queries and becomes instrumental in reducing the run-time of the algorithm. It also significantly reduces the computation time per neighbourhood query while producing exact DBSCAN clusters. Moreover, the micro-cluster based solution makes it scalable for high dimensional data. We also propose a highly scalable distributed implementation of μDBSCAN, μDBSCAN-D, to exploit a commodity cluster infrastructure. Experimental results demonstrate tremendous improvements in performance of our proposed algorithms as compared to their respective state-of-the-art solutions for various standard datasets. μDBSCAN-D is an exact parallel solution for DBSCAN which is capable of processing massive amounts of data efficiently (1 billion data points in 41 minutes on a 32 node cluster), while producing a clustering that is same as that of traditional DBSCAN.
Evaluating Methods for Emotion Recognition based on Facial and Vocal Features

An automatized emotion recognition based on Information and Communication Technology (ICT) is currently of high interest and opens possibilities for various applications. Emotions are a key feature in communication and the possibility of recognizing emotions may advance Human Computer Interaction. Furthermore unobtrusive emotion recognition can be used to determine levels of stress while handling machines and vehicles and helps to reduce the risk of car crashes or accidents at work. The e-health sector benefits from emotion recognition to monitor mental states of patients at home and to improve recovery rates through a more personalized care. Emotion recognition might be useful to predict emotions from patients who are unable to express their emotions, for example patients suffering from autism, Parkinsons or locked-in syndrome. At the moment several methods for an ICT based emotion recognition exist. The methods vary in terms of precision, usability, application area as well as number of emotions which can be detected. An overview of methods used for emotion recognition and the current state of the art is given in this paper. The paper is focusing on evaluating existing tools for emotion recognition based on facial features as well as vocal features in voice interactions. The methods have been tested for its usability in the field of e-health and applications for elderly care. A case study was conducted to elicit emotions in 20 participants after presenting them an affective video based on rated picture and sound databases. Furthermore, video recordings of the frontal face as well as spoken texts were used for testing the usability of the three projects. The results suggest that facial recognition works best for the emotion happiness while voice recognition works best for the emotion anger. Copyright c © 2019 by the paper’s authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0). In: E. Calvanese Strinati, D. Charitos, I. Chatzigiannakis, P. Ciampolini, F. Cuomo, P. Di Lorenzo, D. Gavalas, S. Hanke, A. Komninos, G. Mylonas (eds.): Proceeding of the Poster and Workshop Sessions of AmI-2019, the 2019 European Conference on Ambient Intelligence, Rome, Italy, 13-11-2019, published at http://ceur-ws.org
Central Line-Associated Blood Stream Infection (CLABSI)

Pa tie nt & fa m ily e du ca tio n FUNDAMENTAL (check each box if “yes”) The facility has a process in place to educate the patient/family about their central line [1,2]. Include topics such as what a central line-associated bloodstream infection is, what the health care personnel (HCP) and prescribers are doing to prevent an infection, and what the patient can do to help prevent an infection. Encourage patients to report any new changes or discomfort in their catheter site [3]. The facility has a process in place to educate patients being discharged with a central line in place [1,2]. Topics include catheter care and symptoms of infection. Teach back methods can be utilized to ensure patient understanding. Consider the following examples of patient education when developing teaching materials: • MHA Checking CLABSI patient education sheet • Centers for Disease Control fact sheet • The Ohio State University Wexner Medical Center CVC sterile dressing change patient education
Review: Testing and Measurement in Occupational Therapy: A Review of Current Practice with Special Emphasis on the Southern California Sensory Integration Tests

real clarity. The authors' wide teaching experience is clearly evident in this logical and well-written text. While some people may want more detail on a given research process, or feel that their more difficult questions are not addressed adequately, such information is readily available in a wide variety of sources, which are referenced in this book. Health care practitioners who are at the entry level in the research realm-be they on the verge of entering the field or on the verge of entering research after 30 years in the field-will find this small book a source of inspiration and support, as well as a reliable guide to successful research.
Educational Requirements Analysis for Information Security Professionals in Korea

The IT industry in Korea, having recognized the importance of Information Security (IS), is in pressing need of IS Managers (ISMs) and IS System Developers (ISSDs). Many educational institutions, both universities and training organizations, are developing IS courses to meet this demand. For these educational programs to be successful, their design should address the specific knowledge required by IS professionals. In this paper, the authors first identify and rank the knowledge requirements of IS professionals using a simplified Delphi technique. They then, through refined analysis, come up with two sets of 15 specific educational requirements, one each for ISMs and ISSDs.
Predicting the Annual Salaries of Construction Educators using Multiple Regression

The development of a mathematical model to predict the annual salaries of construction educators is presented. A review of the literature identified a number of factors that are hypothesized to affect the annual salary of construction educators; academic qualifications, longevity, academic rank, parent college of the department, region in which the institution is located and gender. The responses from the annual ASC Faculty Salary Survey were used to develop a multiple regression model that predicts the annual 9-month salary of a construction educator. The stepwise selection method was used to select seven independent qualitative or dummy variables to include in the model. The model developed does not have a very high predictive efficacy as only 51 percent of the variation in the dependent variable (annual 9-month salary) is explained by the variation in the selected independent variables. The variables selected for the model includes levels of academic rank, academic qualifications, region in which the institution is located and parent college of the department. Independent variables representing longevity and gender were not included in the model.
Femoral and tibial torsion measurements based on EOS imaging compared to 3D CT reconstruction measurements.

Background The EOS imaging system is an advanced piece of equipment for full-body imaging, but its reliability and reproducibility should be further verified. Methods A prospective study was conducted including 18 adult volunteers (36 lower extremities) (24±2 years old). Femoral and tibial torsion were measured by both EOS imaging and three-dimensional computed tomography (3D CT) reconstruction. Bland-Altman plots were performed to evaluate the difference between femoral and tibial torsion measurements obtained by these two methods. The intraclass correlation coefficient (ICC) was used to evaluate intrareader agreement. Results The mean difference between the two methods was 3° (range, -9° to 4°) for femoral torsion, 0° (range, -6° to 6°) for tibial torsion and 0° (range, -4° to 5°) for femorotibial torsion. No statistically significant difference between the measurements of the two methods was detected by Bland-Altman plots. With the exception of one measurement of femoral torsion, one measurement of tibial torsion and one measurement of femorotibial torsion, all EOS imaging measurements were within the 95% limits of agreement (the mean ± 1.96 SD). Intrareader agreement was statistically significant (P<0.001) for all measurements, with high ICCs. For EOS imaging, the ICC was 0.92 for the femoral measurement, 0.92 for the tibial measurement and 0.918 for the femorotibial measurement; the corresponding values for CT were 0.950, 0.927 and 0.889. Conclusions There was good agreement between EOS imaging based and 3D CT reconstruction based technique in measuring femoral, tibial and femorotibial torsion; and good reliability and reproducibility of EOS Imaging in measuring femoral, tibial and femorotibial torsion was also verified.
Analysis of genome sequence and trehalose lipid production peculiarities of the thermotolerant Gordonia strain

Gordoniae are one of the most promising hydrocarbon‐oxidizing actinobacteria. Here we present the genome sequence analysis of thermotolerant strain Gordonia sp. 1D isolated from oil‐refinery soil. It is capable of alkane consumption and biosurfactant production at temperatures of up to 50°C. Gordonia sp. 1D demonstrates maximum biosurfactant production when grown on hexadecane, and at 40°C it was slightly higher than at 27°C: 35 and 39 mN/m, respectively. For the first time, it was experimentally confirmed that the carbohydrate component of extracellular biosurfactants produced by strain 1D is trehalose. In addition, genes for the production of trehalose lipid biosurfactants were identified. The genetic determinants for two different pathways for trehalose synthesis were found. The strain carries genes otsA and otsB involved in de novo trehalose biosynthesis. Moreover, the genes treY and treZ responsible for trehalose biosynthesis from maltooligosaccharides and starch or glycogen were identified.
Adaptation in structured populations and fuzzy boundaries between hard and soft sweeps

Selective sweeps, the genetic footprint of positive selection, have been extensively studied in the past decades, with dozens of methods developed to identify swept regions. However, these methods suffer from both false positive and false negative reports, and the candidates identified with different methods are often inconsistent with each other. We propose that a biological cause of this problem can be population subdivision, and a technical cause can be incomplete, or inaccurate, modeling of the dynamic process associated with sweeps. Here we used simulations to show how these effects interact and potentially cause bias. In particular, we show that sweeps maybe misclassified as either hard or soft, when the true time stage of a sweep and that implied, or pre-supposed, by the model do not match. We call this “temporal misclassification”. Similarly, “spatial misclassification (softening)” can occur when hard sweeps, which are imported by migration into a new subpopulation, are falsely identified as soft. This can easily happen in case of local adaptation, i.e. when the sweeping allele is not under positive selection in the new subpopulation, and the underlying model assumes panmixis instead of substructure. The claim that most sweeps in the evolutionary history of humans were soft, may have to be reconsidered in the light of these findings.
PlantRegMap: charting functional regulatory maps in plants

Abstract With the goal of charting plant transcriptional regulatory maps (i.e. transcription factors (TFs), cis-elements and interactions between them), we have upgraded the TF-centred database PlantTFDB (http://planttfdb.cbi.pku.edu.cn/) to a plant regulatory data and analysis platform PlantRegMap (http://plantregmap.cbi.pku.edu.cn/) over the past three years. In this version, we updated the annotations for the previously collected TFs and set up a new section, ‘extended TF repertoires’ (TFext), to allow users prompt access to the TF repertoires of newly sequenced species. In addition to our regular TF updates, we are dedicated to updating the data on cis-elements and functional interactions between TFs and cis-elements. We established genome-wide conservation landscapes for 63 representative plants and then developed an algorithm, FunTFBS, to screen for functional regulatory elements and interactions by coupling the base-varied binding affinities of TFs with the evolutionary footprints on their binding sites. Using the FunTFBS algorithm and the conservation landscapes, we further identified over 20 million functional TF binding sites (TFBSs) and two million functional interactions for 21 346 TFs, charting the functional regulatory maps of these 63 plants. These resources are publicly available at PlantRegMap (http://plantregmap.cbi.pku.edu.cn/) and a cloud-based mirror (http://plantregmap.gao-lab.org/), providing the plant research community with valuable resources for decoding plant transcriptional regulatory systems.
Commentary on Bridge Flaps.

The scalp presents a unique challenge to aesthetic and functional reconstruction. In the hirsute scalp, it may be the thickest integument in the body, measuring 3 to 8 mm in thickness; yet in a bald, photodamaged scalp, it can be thin to the point of near transparency. The scalp plays an important functional role in that it covers the bony calvarium. Defects that expose the periosteum and bone present an additional challenge. The lack of elasticity of the scalp requires the use of very long incisions to distribute tension sufficiently to allow closure. With a rotation flap, an incision 4 to 6 times the length of the original defect size is required. The rich vascularity of the scalp can make procedures bloody, leading some to advocate the use of hemostatic Rany clips. The decision-making process when choosing reconstructive options on the scalp requires the surgeon to take into account a wide range of factors. An algorithmic approach has been advocated. Defect size is the key consideration. Others include the precise anatomical location on the scalp, a history of previous radiation therapy, and hairline distortion.
Intermittent self catheterisation with hydrophilic, gel reservoir, and non-coated catheters: a systematic review and cost effectiveness analysis

Objective To determine the most effective and cost effective type of catheter for patients performing intermittent self catheterisation in the community. Results Eight studies were included in the systematic review. Most were conducted in patients with spinal cord injuries, and most of the included patients were men. People using gel reservoir and hydrophilic catheters were significantly less likely to report one or more UTIs compared with sterile non-coated catheters (absolute effect for gel reservoir = 149 fewer per 1000 (95% confidence interval −7 to 198), P=0.04; absolute effect for hydrophilic = 153 fewer per 1000 (−8 to 268), P=0.04). However, there was no difference between hydrophilic and sterile non-coated catheters when outcomes were measured as mean monthly UTIs (mean difference = 0.01 (−0.11 to 0.09), P=0.84) or total UTIs at 1 year (mean difference = 0.18 (−0.50 to 0.86), P=0.60). There was little difference in the incidence of one or more UTIs for people using clean versus sterile non-coated catheters (absolute effect = 12 fewer per 1000 (−134 to 146), P=0.86). Although the most effective, gel reservoir catheters cost >£54 350 per QALY gained and are therefore not cost effective compared with clean non-coated self catheterisation.