Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham Activation of SREBP1-mediated lipogenesis by the Epstein-Barr Virus-encoded LMP1 promotes cell proliferation and progression of nasopharyngeal carcinoma.

Nasopharyngeal Carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. The EBV-encoded latent membrane protein 1 (LMP1), which is commonly expressed in NPC, engages multiple signaling pathways that promote cell growth, transformation and metabolic reprogramming. Here, we report a novel function of LMP1 in promoting de novo lipogenesis. LMP1 increases the expression, maturation and activation of sterol regulatory element-binding protein 1 (SREBP1), a master regulator of lipogenesis, and its downstream target: fatty acid synthase (FASN). LMP1 also induces de novo lipid synthesis and lipid droplet formation. In contrast, siRNA knockdown of LMP1 in EBV-infected epithelial cells diminished SREBP1 activation and lipid biosynthesis. Furthermore, inhibition of the mTOR pathway, either through the use of mTOR inhibitors or siRNAs significantly reduced LMP1-mediated SREBP1 activity and lipogenesis, indicating that LMP1 activation of the mTOR pathway is required for SREBP1-mediated lipogenesis. In primary NPC tumors, FASN overexpression is common, with high levels correlating significantly with LMP1 expression. Moreover, elevated FASN was associated with aggressive disease and poor survival in NPC patients. Luteolin and fatostatin, two inhibitors of lipogenesis, suppressed lipogenesis and proliferation of nasopharyngeal epithelial cells; effects which were more profound in cells expressing LMP1. Luteolin and fatostatin also dramatically inhibited NPC tumor growth in vitro and in vivo . Our findings demonstrate that LMP1 activation of SREBP1-mediated lipogenesis promotes tumor cell growth and is involved in EBV-driven NPC pathogenesis. Our results also reveal the therapeutic potential of utilizing lipogenesis inhibitors in the treatment of locally advanced or metastatic NPC.
Leadership and Teachers’ Morale in Senior Secondary Schools in Plateau State, Nigeria

The study examined the relationship between principals’ leadership styles and teachers’ morale in senior secondary schools in Plateau State. The correlation research design was used for the study. The population of the study comprised of 39 principals and 229 teachers who have spent at least three years working together in the Senior Secondary Schools of Barkin Ladi and Langtang North Local Government areas in Plateau State. The sample consists of 31 principals and 137 teachers out of the population. The instruments used for data collection were the Principal Leadership Style Questionnaire (PLSQ) and Teachers’ Questionnaire (TQ). Data were analyzed using the frequency count, percentage, and Pearson Product Moment correlation coefficient (Pearson r). Findings were; there was positive statistical significant relationship between principals’ democratic leadership style and teachers’ morale; there was negative statistical significant relationship between principals’ autocratic leadership style and teachers’ morale; while there was no statistical significant relationship between the laissez-faire leadership style and teachers’ morale. In addition, principals were found to dominantly practice the democratic leadership style and teachers’ morale was confirmed to be moderate in the Senior Secondary Schools. Base on the findings recommendations were made some of which are; Principals should be sent for in-service-training to study leadership in school; to organize workshops, seminars and conferences for principals of secondary schools on leadership styles; and to create awareness on the importance of teacher morale in school effectiveness.
Ontogenetic perspectives on modern human long bone growth: the humerus

Biological anthropologists routinely infer ancient human behaviour from macroscopic skeletal markers, although the underlying relationship between bone growth and functional adaptation remains complex. To date, few studies have undertaken a microstructural analysis of bone plasticity in relation to ontogeny. The primary aim of this study is to map histological changes within the humerus with age. If the histological changes have a strong correlation with age then it will be possible to produce a regression equation to predict juvenile age-at-death. This is the secondary aim of the study. The final aim is to ascertain how bone robusticity influences bone growth, within age-matched juveniles. A sample of 83 juvenile skeletons from St. Gregory’s Priory, Canterbury were aged using standard methods. One 0.5 cm histological section was removed from the anterior humeral midshaft of each skeleton. Histological slides were prepared using standard methods. The density and morphometrics of primary osteons and secondary osteons were recorded using a high resolution microscope. Results show that primary osteon population density has a strong negative correlation with age (rs = -0.672, N = 83, p < 0.0005). Secondary osteon population density has a strong positive correlation with age (rs = 0.878, N = 83, p < 0.0005). A regression equation to estimate age at death from primary and secondary osteon population density was produced. The equation can be used to estimate juvenile age-at-death, between 0 - 17 years of age, with 86.1% accuracy. In an age matched sub-group robusticity was found to have a negative correlation with secondary osteon population density (rs = -0.642, N = 35, p < 0.001).
The Economy of Projects: Analyzing Project Management Resilience, Stress Management and Project Sustainability

The due economy of projects is a catchword nowadays in the world. Advancement in project sustainability has reshaped the banking across the globe forcing companies to perform tasks and activities in the form of projects; resilience, stress management are some of the factors that redesign project sustainability. This cross-sectional study investigates the impact of resilience and stress management on project sustainability also making a contribution by analyzing the association of resilience and stress management. The beta values and results show in favor of acceptance of the entire hypothesis. The data was collected from the members of the project team working on a diverse project in the banking sector of Pakistan. The instrument used to collect the data was questionnaires to measure each variable. Pearson correlation and stepwise hierarchal regression were used to analyze the data. The study at the end highlights valuable findings and recommendations for the future and the researchers offer practical guidance further professionalizing Project Management.
Spectroscopie des liants routiers : nouvelles approches macroscopiques. Relations pétroles bruts et caractéristiques des liants. Etude des interactions bitumes / polymères par microscopie IRTF

Actuellement, compte-tenu de la diversite des petroles et des differentes possibilites de formulation, il existe une grande variete de liants routiers, pouvant etre modifies par divers agents (polymeres,. . . ). Aussi les methodes de caracterisation physico-chimique de ces bitumes modifies doivent mettre en oeuvre non plus uniquement des approches macroscopiques mais egalement des approches microscopiques, ideales pour caracteriser in situ les differents constituants. Cependant, une des difficultes industrielles de fabrication des bitumes est de pouvoir choisir rapidement, suivant les contraintes du moment, un brut ou melange de bruts conduisant aux caracteristiques finales desirees pour le materiau. Afin d'apporter des reponses a ce probleme industriel, une nouvelle approche macroscopique de l'etude spectroscopique des bitumes, basee sur le traitement statistique d'indices spectroscopiques, a ete developpee et a permis de definir des "atlas" de bitumes. Ceux-ci sont d'un grand interet pratique industriellement comme aide decisionnelle. Une mise au point de modeles explicatifs par regression multiple ou par regression des moindres carres partiels a egalement permis d'identifier les liens existant entre les descripteurs chimiques et physiques. Neanmoins, malgre un choix judicieux de petroles, les bitumes subissent toujours des reactions de vieillissement, entrainant une perte des performances mecaniques. Aussi, afin de limiter cela, un ajout de polymeres est necessaire. Les Bitumes Modifies par des Polymeres (BmP) sont donc des materiaux composites ayant une structure extremement complexe. Comprendre comment la micromorphologie de ces systemes est affectee par la composition chimique est un objectif de recherche important. Par consequent, la microscopie infrarouge et la microscopie de fluorescence UV/visible s'averent indispensables pour caracteriser chimiquement in situ les microphases en equilibre dans les BmP. Il a ainsi ete possible de demontrer la presence, au sein des BmP, de zones bitumineuses fortement enrichies en polymere suivant un continuum a gradient, de preciser la repartition homogene du polymere dans le cas d'une reticulation au soufre et de definir les especes gonflant le polymere (qui seraient des aromatiques faiblement condenses substitues par des aliphatiques).
Bioelectricity and biomagnetism

Membrane Transport Phenomena. The Hodgkin--Huxley Membrane. The Ion Channel. Cable Theory and Action Potential Propagation. Extracellular Potentials. Myocardial Anisotropy. Electrocardiography. Electroencephalography. Biomagnetism. Sensory Receptors. Synaptic Transmission and the Neuromuscular Junction. Electromyography. Indexes.
The complete chloroplast genome of Ranunculus Cantoniensis

Abstract The complete chloroplast genome of Ranunculus cantoniensis was determined. Total chloroplast genome was 155,119 bp in lenth, displayed a typical quadripartite structure, including a large single copy (LSC) region of 84,634 bp and a small single copy region (SSC) of 18,879 bp, separated by a pair of inverted repeats (IRs) of 25,803 bp. A total of 131 genes, including 84 protein-coding genes, 37 tRNA genes, and 8 rRNA genes were indentified. Among them, 15 genes have one intron each and 3 genes contain two introns. The overall GC content was 37.9%, while the corresponding values of LSC, SSC, and IR regions were 36.0, 31.1, and 43.5%, respectively. Phylogenetic relationship analysis showed that R. cantoniensis was closely related to R. macranthus.
Demand Pressures and Option Returns

Delta-hedged option and straddle returns on S&P500 Index and equity options computed using end-of-day closing prices are always higher compared to those based on any other price of the day. The difference between these returns can reach more than 100 bps per day. Price pressures combined with options market makers’ overnight inventory risks explain the results. We use an introduction of SPX night trading as a resolution of overnight uncertainty and are able to differentiate price pressure hypothesis from all other mispricing based explanations. Computing returns using first half of the day prices, where most of price discovery takes place, helps explain several anomalies in the literature and establish identical volatility pricing across equity and index options
Soybean protein concentrate in Pacific white shrimp reared in bioflocs: effect on health and vibrio challenge

Litopenaeus vannamei shrimp were reared in a bioflocs system and fed different levels of soybean protein concentrate as a replacement for fishmeal, and both immunological parameters of this marine shrimp and its resistance to Vibrio sp. infection (CPQBA 378-12 DRM01) were evaluated. Four different diets were formulated with 0, 33, 66 and 100 % of soybean protein concentrate as a substitute for fishmeal. Shrimp were reared in a biofloc system in twelve 800 L tanks (250 shrimp m-3) maintained at constant aeration and temperature. After 42 days, 36 animals (14.21 ± 0.89 g) per treatment were challenged with Vibrio sp. (1 x 105 CFU mL-1 – LD10), and hemolymph was collected before and after challenge to perform immunological assays (agglutination titer, concentration of protein and phenoloxidase activity). Shrimp fed with the experimental diets showed no difference in their resistance to infection and haemato-immunological parameters. Thus, rearing L. vannamei in a biofloc system on diets containing either partial or total replacement of fishmeal for soybean protein concentrate did not affect either immunocompetence or susceptibility to infection.
Evaluating the Social and Technological Benefits of an Intergenerational Program for Older Adults

Intergenerational programs are on the rise. While studies have shown benefits to participation in these programs, most of the research has been focused on students and less on older adult outcomes (see Andreoletti & Howard, 2016 for a review). Currently, the University of Rhode Island (URI) is host to the Engaging Generations: Cyber-Seniors Program, which connects older adults with undergraduate technology mentors. The aim of this study was to evaluate the outcomes of intergenerational programming participation for older adults related to social isolation, loneliness, social engagement, and digital competency, as measured by the pre/post surveys given to participants. SPSS software was used to conduct descriptive analysis, paired-sample t Tests, independent sample t Tests, and one-way ANOVAs. Thematic analysis was used for the open-ended participant response. Results showed significant improvements on items of the digital competence scale, particularly in relation to social media and for those who started with lower levels of digital competence. Qualitative analysis showed that the older adults valued the technological knowledge gained, and the pleasant interactions and pedagogy. Program implications and suggestions are discussed.
THE Factors that Influence People Interest in Using a Digital Platform as a ZIS Payment (Case Study Go-Pay)

This article aims to identify the factors that influence someone's interest in transacting zakat, infaq, and sedekah through the digital platform, named Go-pay. Zakat itself is an obligation that must be carried out by Muslims who have fulfilled the requirements. While infaq and sedekah are forms of sunnah worship which do not require special conditions but have one purpose with zakat, which is to give and help those who are not sufficient in fulfilling their daily needs. The potential for zakat collection based on the expected level of growth and Muslim population in Indonesia is not compatible with reality. The number of Muslim population in Indonesia is 80% of the total population and the potential of the collection of zakat in 2017 is Rp. 250.3 trillion, but what was collected was Rp. 6.2 trillion or only 2.47% of the total.
Temperature rise within radioactive liquid wastes injected into deep formations

The data and method of analysis presented here provide for an approximate determination of expected temperature rises. They show that, in general, when large masses of liquid waste are injected into an aquifer through wells, heat conduction is not very significant, and as an approximation the temperature rise within the aquifer, since injection began, is equal to the total heat generated in a unit volume of aquifer divided by the product of the specific gravity of the aquifer and contained waste and its heat capacity. The generalizations outlined here should lead to an understanding of the relative importance of heat storage as compared to thermal conduction away from the region.
Closed Loop Temperature Control System Design Using Conventional and Advanced Intelligent Controller

Requirement of energy demand growing rapidly around the world due to modern suburban life styles and tendency for indoor comfort. These energy stipulation leads to design of intelligent control strategies to make the system energy efficient. Design an efficient room heater to make it energy proficient using intelligent control is an attractive research topic today. This article proposed a design of temperature controller with the purpose to sense the temperature of a room and maintain it to a fixed desired value. Conventional Proportional Integral (PI) controller as well as modern Artificial Neural Network (ANN) based PI controller have been used as the control strategies when a model of PI controller based on ANN with Levenberg-Marquardt learning algorithm has been introduced in this article. The simulation report of projected design has been shown and it has been concluded that the proposed control strategy is very advantageous due to its small overshoot, fast response, and high precision. All designs and simulations have been done in Simulink of Matllab platform.
Barrier function-Based Variable Gain Super-Twisting Controller

In this paper, a variable gain super-twisting algorithm based on a barrier function is proposed for a class of first order disturbed systems with uncertain control coefficient and whose disturbances derivatives are bounded but they are unknown. The specific feature of this algorithm is that it can ensure the convergence of the output variable and maintain it in a predefined neighborhood of zero independent of the upper bound of the disturbances derivatives. Moreover, thanks to the structure of the barrier function, it forces the gain to decrease together with the output variable which yields the non-overestimation of the control gain.
Tomato Suspension Agreements and the Effects on Market Prices and Farm Revenue

The production capacity of the US tomato industry has decreased significantly in the past decade. The US Department of Commerce and the Mexican tomato industry negotiated and signed several Suspension Agreements that set floor prices for imported Mexican fresh tomatoes to protect the US domestic industry. This 4-page article written by Zhengfei Guan, Dong Hee Suh, and Feng Wu and published by the UF/IFAS Food and Resource Economics Department provides a review of the history of the suspension agreements and an analysis of their effects on the US tomato industry. http://edis.ifas. ufl.edu/fe1025
An Analysis of Global and RegionalMainstreaminess for Personalized MusicRecommender Systems

The music mainstreaminess of a listener reflects how strong a person’s listening preferences correspond to those of the larger population. Considering that music mainstream may be defined from different perspectives, we show country-specific differences and study how taking into account music mainstreaminess influences the quality of music recommendations. In this paper, we first propose 11 novel mainstreaminess measures characterizing music listeners, considering both a global and a countryspecific basis for mainstreaminess. To this end, we model preference profiles (as a vector over artists) for users, countries, and globally, incorporating artist frequency, listener frequency, and a newly proposed TF-IDF-inspired weighting function, which we call artist frequency–inverse listener frequency (AF-ILF). The resulting preference profile for each user u is then related to the respective country-specific and global preference profile using fraction-based approaches, symmetrized Kullback-Leibler divergence, and Kendall’s τ rank correlation, in order to quantify u’s mainstreaminess. Second, we detail country-specific peculiarities concerning what defines the countries’ mainstream and discuss the proposed mainstreaminess definitions. Third, we show that incorporating the proposed global and country-specific mainstreaminess measures into the music recommendation process can notably improve accuracy of rating prediction.
Computational Subsurface Hydrology: Reactions, Transport, and Fate

List of Figures. List of Tables. Preface. 1: Fundamental of the Subsurface System. 1.1. Study of the Subsurface System. 1.2. The Fundamental Concept of Continuum. 1.3. Basis of Conceptual Mathematical Models. 1.4. References. 2: Reactive Geochemical and Biochemical Transport. 2.1. Preliminary to Geochemical Equilibrium Systems. 2.2. General Geochemical Equilibrium Systems. 2.3. Geochemical Kinetic Systems. 2.4. Mixed Geochemical Kinetic and Equilibrium Systems. 2.5. Mathematical Formulation of Solute Transport. 2.6. Microbe Transport and Fate. 2.7. Generalized Reactive Transport in Variably Saturated Media. 2.8. Mathematical Strategies for Reactive Transport. 2.9. References. 3: Numerical Methods for Advection-Dominant Transport. 3.1. Introduction. 3.2. Eulerian Approaches. 3.3. Lagrangian-Eulerian Approaches. 3.5. References. 4: Finite-Element Modeling of One-Component Solute Transport. 4.1. Mathematical Models of Solute Transport Under Variably Saturated Flows. 4.2. Finite-Element Modeling of Solute Transport in Variably Saturated Media. 4.3. Mathematical Models of Solute Transport Under Saturated Flows. 4.4. Finite-Element Modeling of Solute Transport in Saturated Media. 4.5. Derivation of Vertically Integrated Transport Equations. 4.6. Finite-Element Modeling of Solute Transport in Aquifers. 4.7. References. 5: Coupled Fluid Flow and Reactive Chemical Transport. 5.1. Introduction. 5.2. Mathematical Model. 5.3. Numerical Solutions. 5.4. Example Problems. 5.5. References. Index.
The Psychology of Creative Processes in Music

In contrast to cerebral or mentalistic psychological accounts of creative processes, this chapter argues for an approach based within the frameworks of ecological theory and 4E cognition—the idea that psychological functioning is embodied, extended, embedded, and enacted. The chapter considers “everyday” and exceptional notions of the creative process and reviews cognitive models of musical creativity as a form of decision-making, as well as the tension between individualistic and social perspectives. As an alternative, it offers an account that recognizes the reciprocal relationship between materials (instruments, notations, tuning systems, recording/playback systems) and human minds and bodies conceived individually and collectively, drawing attention to four important features of musical creating: (1) the different scales at which it takes place, (2) its temporality, (3) its distributed and collaborative character, and (4) its intimate entanglement with environmental affordances.
Macrophage migration inhibitory factor of Syrian golden hamster has similar structure and function as human MIF and promotes pancreatic tumor growth

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that increasingly is being studied in cancers and inflammatory diseases. Though murine models have been instrumental in understanding the functional role of MIF in different pathological conditions, the information obtained from these models is biased towards a specific species. In experimental science, results obtained from multiple clinically relevant animal models always provide convincing data that might recapitulate in humans. Syrian golden hamster (Mesocricetus auratus), is a clinically relevant animal model for multiple human diseases. Hence, the major objectives of this study were to characterize structure and function of hamster MIF, and finally evaluate its effect on pancreatic tumor growth in vivo. Initially, the recombinant hamster MIF (rha-MIF) was cloned, expressed and purified in bacterial expression system. The rha-MIF primary sequence, biochemical properties and crystal structure analysis showed a greater similarity with human MIF. The crystal structure of hamster MIF illustrates that it forms a homotrimer as known in human and mouse. However, hamster MIF exhibits some minor structural variations when compared to human and mouse MIF. The in vitro functional studies show that rha-MIF has tautomerase activity and enhances activation and migration of hamster peripheral blood mononuclear cells (PBMCs). Interestingly, injection of rha-MIF into HapT1 pancreatic tumor bearing hamsters significantly enhanced the tumor growth and tumor associated angiogenesis. Together, the current study shows a structural and functional similarity between hamster and human MIF. Moreover, it has demonstrated that a high-level of circulating MIF originating from non-tumor cells might also promote pancreatic tumor growth in vivo.