Miracle-dz/UniFAR-FTUs huggingface dataset:
An approach for analyzing the ensemble mean from a dynamic point of view

Simultaneous ensemble mean equations (LEMEs) for the Lorenz model are obtained, enabling us to analyze the properties of the ensemble mean from a dynamical point of view. The qualitative analysis for the two-sample and n-sample LEMEs show the locations and number of stable points are different from the Lorenz equations (LEs), and the results are validated by numerical experiments. The analysis for the eigenmatrix of the stable points of LEMEs indicates that the stability of these stable points is similar to the LEs'. The eigenmatrix for non-stable points can be obtained too, but the eigenvalues depend not only on the value of the mean variable but also the other n-1 sample equation's variable, and thus for these points there may be different stabilities compared to the LEs'. The divergence of the LEMEs' flow has a negative value, which is the same as the LEs', and thus the trajectory in phase space approaches zero and the trajectory will be attracted to a low-level dimensional curved surface, i.e., the LEMEs have the attractor property, but the structure of the attractor is not the same as the LEs'.
Edinburgh Explorer PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

, Abstract Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we focused on phosphoinositide 3 -kinase (PI 3 K) and its product phosphatidylinositol ( 3 , 4 , 5 )-trisphosphate (PIP 3 ). We demonstrate that adult PNS neurons utilise two catalytic subunits of PI 3 K for axon regeneration: p 110 a and p 110 d . However, in the CNS, axonal PIP 3 decreases with development at the time when axon transport declines and regenerative competence is lost. Overexpressing p 110 a in CNS neurons had no effect; however, expression of p 110 d restored axonal PIP 3 and increased regenerative axon transport. p 110 d expression enhanced CNS regeneration in both rat and human neurons and in transgenic mice, functioning in the same way as the hyperactivating H 1047 R mutation of p 110 a . Furthermore, viral delivery of p 110 d promoted robust regeneration after optic nerve injury. These findings establish a deficit of axonal PIP 3 as a key reason for intrinsic regeneration failure and demonstrate that native p 110 d facilitates axon regeneration by functioning in a hyperactive fashion. Results Our study found that adult PNS neurons use two versions of the enzyme PI 3 -kinase to regenerate their axons, p 110 d and p 110 a . These enzymes generate the phospholipid PIP 3 . Visualisation of PIP 3 in maturing CNS neurons revealed that PIP 3 is strongly downregulated at the time when these neurons lose their regenerative ability. Overexpression of p 110 d elevated axonal PIP 3 and regeneration after laser injury, but p 110 a required the activating H 1047 R mutation to behave similarly, demonstrating that native p 110 d functions in a hyperactive fashion. The study found that p 110 d functioned through multiple mechanisms, including the enhanced transport of regenerative machinery into axons. Importantly, viral delivery of p 110 d to the retina promoted axon regeneration after an optic nerve crush injury and was accompanied by enhanced survival of RGC neurons in the contributing to their weak regenerative ability. Exogenous expression of the p 110 d subunit elevates axonal PI 3 -kinase activity by functioning in a hyperactive fashion, leading to enhanced regeneration in human and rodent models of CNS injury, and enhanced neuroprotection and regenera- tion after a mouse optic nerve crush injury.
D. Shirisha, et al. J Pharm Res, 2019;8(9):638-648

Nanoparticle is novel approach for drug delivery which can achieve better therapeutic action, better bioavailability and reduce toxicity. Nanoparticles are tiny materials whose size ranges from 1-100nm.They can be classified into different classes based on their properties, shapes or sizes. In this review we presented a detailed review about nanoparticles, their types, preparation techniques, evaluation parameters and applications of nanoparticles. Today nanoparticles are successfully used in brain targeting, in cancer therapy etc., nanoparticles gives us an opportunity to enhance patient compliance for better therapy. Several techniques are used for the preparation of Nanoparticles like Solvent Evaporation, Double Emulsification Method, Emulsion – Diffusion method, Nanoprecipitation Method, Coacervation Method, Salting out Method, Dialysis and Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters such as Zeta potential, Particle size and shape, Drug entrapment efficiency, Yield of nanoparticles, In-vitro, kinetic study, and Stability of Nanoparticles.
Application of Palm Kernel Shell as Bio Adsorbent for the Treatment of Heavy Metal Contaminated Water

Contamination of heavy metal in water results are affecting on human health and living creatures. In this study, palm oil kernel shell (PKS) is applied as bio-adsorbent for the treatment of heavy metal contaminated water. Heavy metals namely; Cr6+, Pb2+, Cd2+ and Zn2+ were removed through bio-adsorption on PKS. Parameters of adsorptions namely pH of solution, adsorbent dosage, concentration of metal ions and contact time were optimized. The PKS was able to effectively remove Cr6+, Pb2+, Cd2+ and Zn2+ ions from water with percentage removal of 98.92%, 99.01%, 84.23% and 83.45%, respectively. The Freundlich and Langmuir isotherms models were applied for the adsorption interaction between metal ions and PKS. PKS was found to be very effectively bio-adsorbed for the removal of heavy metal contaminated water within two hours. This is greener approach for the treatment of heavy metal ions contaminated water.
Enhanced Invasive Ductal Carcinoma Prediction Using Densely Connected Convolutional Networks

—Breast cancer is a heterogeneous disease that occurs when malignant cells form in the breast. It is the most common type of cancer in women but, it can also affect men. Due to its invasiveness and frequency of occurrence, breast cancer can be hard to diagnose. Although several approaches utilizing digital pathology and deep learning methods have successfully addressed the issue, these methods fail to capture some intrinsic and extrinsic cellular structural features required for precise automatic detection of Invasive Ductal Carcinoma (IDC) of the breast. Our proposed DenseBreast methodology involves the diagnosis of invasive ductal carcinoma with a densely connected convolutional network (DenseNet) to classify the IDC-affected histopathology images from the normal images. The benchmark dataset thus used to perform this task is the Breast Histopathology Images. The RGB microscopic images are first enhanced through our hybrid pre-processing technique based on color normalization, denoising, adaptive gamma correction (AGC), and contrast limited adaptive histogram equalization (CLAHE) with a 9% image quality improvement compared to the commonly used color normalization by Macenko. These images are then fed to the network which achieves an accuracy of 90%, a balanced accuracy of 87.2%, an improved f-score of 88.0%, and sensitivity/specificity of 80/95 % on a reduced dataset. Classification aptitude of the model is tested using standard performance metrics.
Factors influencing the development and delivery of workshops

Title: Investigating group-based classes (‘weaning workshops’) to support complementary infant feeding in Irish primary care settings: A cross-sectional survey. Abstract: 42 Objective: This study aims to 1) investigate current practice regarding ‘weaning workshops’ to support 43 complementary infant feeding delivered within Irish primary care, 2) explore the experiences and 44 opinions of community dietitians regarding optimal content and modes of delivery of weaning 45 workshops, and 3) identify the key factors to be considered in the development and implementation 46 of weaning workshops delivered within primary care. Results: Sixteen dietitians reported that workshops were run in their area with variable frequency, 51 with ten reporting that workshops were never run in their area. Participants reported that mostly 52 mothers of medium socioeconomic status attended weaning workshops when infants were aged 53 between 4-7 months, and that feedback from workshop attendees was predominantly positive. 54 Dietitians identified that key factors to be considered in future development and delivery of weaning 55 workshops are 1) workshop characteristics such as content, timing and venue, 2) organisational 56 characteristics such as availability of resources and multidisciplinary involvement, and 3) attendee 57 characteristics such as socioeconomic status. 58 Conclusions: This study highlights substantial variability regarding provision of weaning workshops in 59 Ireland, and a lack of standardisation regarding the provider, content, and frequency of workshops 60 where workshops are being delivered. The study also provides unique insights into the experiences 61 and opinions of primary care community dietitians regarding the development and delivery of 62 weaning workshops in terms of optimal content and delivery options. These perspectives will make a 63 valuable contribution given the dearth of evidence in this area internationally. This study provides an overview of current practice regarding the delivery of weaning workshops within the Irish primary healthcare service. The study also provides insight into the experiences and opinions of primary care community dietitians regarding the development and delivery of weaning workshops in terms of optimal content and delivery options. Overall, only 11 dietitians reported experience of personally delivering weaning workshops. Sixteen dietitians reported that workshops were run in their area with variable frequency, with ten reporting that workshops were never run in their area. Participants reported that mostly only mothers of medium socioeconomic status attended weaning workshops when infants were aged between 4-7 months, and that feedback from attendees mostly positive. Dietitians identified the key factors needing to be considered in the delivery of weaning workshops as workshop characteristics such as organisational characteristics multidisciplinary attendee socioeconomic
Radion–Higgs-boson mixing state at the LHC with the Kaluza-Klein contributions to the production and decay

In this paper we study the higgs-radion system of the Randall-Sundum model where matter and gauge fields live in the bulk. We take into account the Kalza-Klein(KK) loop correction for the higgs and the raidion coupling to the gauge bosons. Inspired by the LHC data in 2011 where a sign of the higgs boson has been seen at 125 GeV, we fix the one of the mass eigenstate of the higgs-radion mixed state at 125 GeV, and scan over all the other parameters which have not been excluded by the 2011's data. We find the region of parameters where the scalar particle at 125 GeV have branching ratio larger or smaller than that of the Standard Model(SM) higgs significantly. The predicted ratio Br(ZZ)/Br(gamma gamma) also may be different from that of the SM higgs boson.
The Yeast Two-Hybrid System Detects Interactions between Bacillus subtilis (cid:115) B Regulators

(cid:115) B , the general stress response (cid:115) factor of Bacillus subtilis , is regulated by the products of seven genes ( rsbR , S , T , U , V , W , and X ) with which it is cotranscribed. Biochemical techniques previously revealed physical associations among RsbW, RsbV, and (cid:115) B but failed to detect interactions of RsbR, S, T, U, or X with each other or RsbV, RsbW, or (cid:115) B . Using the yeast two-hybrid system, we have now obtained evidence for such interactions. The yeast reporter system was activated when RsbS was paired with either RsbR or RsbT, RsbR was paired with RsbT, and RsbV was paired with either RsbU or RsbW. In addition, RsbW 2 and RsbR 2 dimer formation was detected. RsbX failed to show interactions with itself or any of the other sigB operon products. (cid:115) B is the general stress response (cid:115) factor of Bacillus subtilis (5, 8, 23). A drop in the bacterium’s intracellular ATP or exposure to environmental stress (e.g., heat shock or ethanol) activates (cid:115) B by triggering its release from an inhibitory complex with an anti- (cid:115) B protein (1, 6, 8,
Determinants of tobacco smoking among presumptive TB patients in Taungoo Township, Myanmar

Determinants of tobacco smoking among presumptive TB patients in Taungoo Township, Myanmar. Pub. Dev. A hospital-based cross-sectional study was conducted in Taungoo Township, Myanmar to examine prevalence and determinants of current tobacco smokers among presumptive TB patients aged 18 years and above. A total of 400 presumptive TB patients which was drawn by purposive sampling were face-to-face interviewed using a structured questionnaire in April, 2017. The questionnaire had three parts: socio-demographic factors, socio-environmental factors and psycho-social factors based on social cognitive theory. Harmful alcohol drinking and mental distress were measured by using Alcohol Use Disorders Identification Test (AUDIT-C) and Kessler Psychological Distress Scale (K-10), respectively. Current tobacco smokers, the outcome measure were identified based on questionnaires of Global Adult Tobacco Survey (GATS). Chi-square test and multiple logistic regression were used to examine determinants of tobacco smoking. for primary school or less compared to college or university), income (Adj OR=3.05, 95%CI=1.42-6.54 for middle income compared to low income), marital status (Adj OR=1.97, 95%CI=1.01-3.81 for living without a spouse compared to living with a spouse), harmful alcohol drinking (Adj OR=3.42, 95%CI=1.77-6.60), mental distress (Adj OR=2.97, 95%CI=1.12-7.89), and knowledge about smoking hazards (Adj OR=4.94, 95%CI=2.49-9.76 for middle level, and Adj OR=6.50, 95%CI=2.45-17.24 for low level compared to high level). This study showed one in two presumptive TB patients were current smokers. Current smokers were particularly male, from low socioeconomic status and had poor knowledge, lived alone, drank alcohol, and had mental distress. This could help policy makers to identify people at risk of negative health outcomes of diseases, and promote the tobacco cessation services with integrated alcohol intervention in health facilities as a component of TB program in Myanmar. in from Quality Assurance and of Health, This study showed high prevalence of current tobacco smokers (54%) among presumptive Factors related to were This could help makers to establish
PREVALENCE RATE OF ASTHMA AND ASSESSMENT OF PEOPLES KNOWLEDGE ABOUT ITS OCCURRENCE, A RURAL AND URBAN SURVEY IN PAKISTAN

: Background: The aim of the study was to determine prevalence rate of asthma , also accesses knowledge about its occurrence among people of Pakistan living in different rural and urban areas. Methods: study was conducted in the month of January 2019 in different rural and urban areas of Pakistan. Data was collected from peoples of different age groups suffered from asthma residing in different rural and urban areas of Pakistan. A self- structured questionnaire was designed containing different questions. Percentages of different variables were calculated. Results: Total no. of 500 peoples suffered from asthma were approached including male 346(69.2%) and female 154(30.8%). Prevalence rate is higher in male as compared to females. In our survey mostly people suffered from disease were 32-44 years old 337(67.4%). Also peoples living in urban areas 273(54.6%) were more suffered from this disease as compared to rural 227(45.4%). Conclusion: It is concluded from survey (knowledge assessment part )that peoples were well aware about reasons of occurrence of asthma but majority think dust, consumption of higher quantities of Ghee and rice and unhygienic conditions leads towards asthmatic conditions (table.3).
A TECHNIQUE FOR PERCEIVING ABUSIVE BANGLA COMMENTS

—Most of the research on abusive comments or text detection is conducted in English, some of which are intended to detect humiliating or insulting text. But a few works are found in the Bangla language. Detecting abusive text for Bangla language will be helpful to prevent cyber crimes such as online blackmailing, harassment and cyber bullying which are nowadays becoming the main concern in Bangladesh. Our goal is to detect abusive Bangla comments that are gathered from different social sites where people share their views, feelings, opinions, etc. in this paper. In order to classify a bangla comments is abusive or not, we proposed a root level algorithm and also proposed uni-gram string features to achieve a better result. We have collected several comments from renowned social media Facebook for our work.
Validity of a modified food and nutrition literacy questionnaire in primary school children in Iran

Abstract The present study aimed to assess the relative validity and reliability of a modified Food and Nutrition Literacy (M-FNLIT) questionnaire in primary school children in the city of Mashhad. The study was conducted in four phases. In the first step, the content and face validity of the questionnaire were evaluated by Delphi consensus as well as interviewing the students. Then, construct validity was examined using Confirmatory Factor Analysis (CFA). The internal consistency and reliability of the questionnaire were also assessed using Cronbach α and Intraclass Correlation Coefficient (ICC), respectively. Finally, a receiver operating characteristic analysis was performed to detect the cut-off scores of the M-FNLIT scale. Findings of two rounds of Delphi showed satisfactory levels of Content Validity Ratio: 0·72 and 0·92, Content Validity Index (CVI): 0·92 and 0·98, respectively. The results of CFA for domains and subscales of the M-FNLIT questionnaire including cognitive domain (understanding food and nutrition information and nutritional health knowledge) and skill domain (functional, food choice, interactive, and critical skills) indicated acceptable fit indices. M-FNLIT subscale-specific Cronbach α values ranged between 0·68 and 0·8 and ICC was 0·95 (95 % CI 0·93, 96). The final questionnaire included forty items (thirty-six Likert-type and four true-false items). FNLIT scores were categorized as low (≤ 58), medium (> 58–< 81), and high (≥ 81). The M-FNLIT questionnaire has a good level of validity and reliability to measure food and nutrition literacy in primary school children. The questionnaire can be applied in the evaluation of nutritional interventions in this age group.
DOCUMENTING ATTACHMENT: Aff ective border control in applications for family reunifi cation

From 2002 to 2018, Denmark was the only country in the world to enforce a migration law demanding that couples seeking family reunifi cation in Denmark documented their combined “attachment” to the Danish nation. This article investigates the practice of documenting such national attachment through the so-called “application packets”. Investigating the attachment requirement as a migration political tool with aff ective investments and implications, we suggest that the documentation process can be understood as a performative process in which the application packets lay out a trajectory of “happy objects” (Ahmed 2010): the application, family reunifi cation, a residence permit and ultimately the nation itself. Although the applicants are urged to orient themselves towards the Danish nation as a happy object with the promise of a possible future in Denmark, this promise may have cruel implications for the applicants. Suggesting that an interdisciplinary meeting point between the fi elds of migration studies and cultural/discursive studies may form as fruitful, this article invites readers to think about the biopolitics of border control in aff ective terms
A systematic review and meta‐ethnographic synthesis of Mindfulness‐based Cognitive Therapy for people with major depression

Abstract Background Mindfulness‐based Cognitive Therapy (MBCT) is a relapse‐prevention intervention for people experiencing major depression. Three qualitative meta‐syntheses investigating experiences of taking part in MBCT and/or Mindfulness‐based Stress Reduction (MBSR) across different diagnostic populations reported themes including control, choice, group processes, relationships and struggles. As multiple studies have been published since, we aimed to update, systematically review and synthesize the experiences of participants with depression taking part in MBCT. Methods Four databases were searched systematically (PsycInfo, Web of Science, Medline and CINAHL) up to and including 12 November 2021. Twenty‐one qualitative studies met the review criteria. All papers were rated as fair using a quality appraisal tool. Meta‐ethnography was applied. Results Across 21 studies of participants with current or previous depression who had participated in MBCT, three overarching themes were developed: ‘Becoming skilled and taking action’, ‘Acceptance’ and ‘Ambivalence and Variability’. Participants became skilled through engagement in mindfulness practices, reporting increased awareness, perspective and agency over their experiences. Participants developed acceptance towards their experiences, self and others. There was variability and ambivalence regarding participants' expectations and difficulties within mindfulness practices. Limitations Many studies were conducted in MBCT‐research centres that may hold conflicts of interest. Many studies did not address the impact of the participant–researcher relationship thus potentially affecting their interpretations. Studies were skewed towards the experiences of female participants. Conclusions Our findings help to enhance participant confidence in MBCT, alongside understanding the processes of change and the potential for difficulties. MBCT is beneficial and provides meaningful change for many but remains challenging for some.