Miracle-dz/UniFAR-FTUs huggingface dataset:
An explorative study of the technology transfer coach as a preliminary for the design of a computer aid

The university technology transfer coach has an important role in supporting the commercialization of research results. This thesis has studied the technology transfer coach and their needs in the coaching process. The goal has been to investigate information needs of the technology transfer coach as a preliminary for the design of computer aids.Using a grounded theory approach, we interviewed 17 coaches working in the Swedish technology transfer environment. Extracted quotes from interviews were openly coded and categorized. The analysis show three main problem areas related to the information needs of the technology transfer coach; awareness, communication, and resources. Moreover, 20 features for future computer aids were extracted from the interview data and scenarios and personas where developed to exemplify the future use of computer aids.We conclude that there is a need for computer support in the coaching process. Such systems should aid the coach in; awareness, aiding the coach to focus on meetings; communication, aid the coach to transfer commercialisation knowledge; and resources, aid the coach in accessing and delivering of resources to the coachee. However, it is imperative that the computer aids do not interfere with the coach current process; and that the computer aid is not seen as the sole solution.
CRISPR-dependent endogenous gene regulation is required for virulence in piscine Streptococcus agalactiae

ABSTRACT The clustered regularly interspaced palindromic repeats (CRISPR)-Cas (CRISPR-associated) system is a prokaryotic defence against invading mobile genetic elements, such as bacteriophages or exogenous plasmids. Beyond this, this system has been shown to play an important role in controlling the virulence of some bacterial pathogens. Streptococcus agalactiae strain GD201008-001, a causative agent of septicemia and meningitis in tilapia, contains a single type II CRISPR-Cas system with Cas9 as a signature protein. In this study, we found that the deletion of CRISPR significantly reduced adhesion, invasion, cytotoxicity and haemolysis, and caused severely attenuated virulence in the piscine S. agalactiae strain. RNA-Seq identified 236 endogenous genes regulated by CRISPR, with 159 genes upregulated and 77 genes downregulated. The resulting change in gene transcription by CRISPR was much more pronounced than that by cas9 in this bacterium, indicating CRISPR-mediated endogenous gene regulation was mostly independently of cas9. Subsequent studies showed that CovR/S two-component system was transcriptionally upregulated due to CRISPR deletion, which repressed the expression of the cylE gene coding for a cytolytic toxin, and thus decreased the activity of β-haemolysin/cytolysin. However, upregulation of CovR/S was not the contributor to the attenuation phenotype of ΔCRISPR. Further, we demonstrated that CRISPR is capable of repressing the expression of Toll-like receptor 2 (TLR2)-activating lipoprotein Sag0671 and thus dampens the innate immune response. This study revealed that the CRISPR system of S. agalactiae exhibited extraordinary potential capability in the regulation of endogenous transcripts, which contributes to bacterial innate immune evasion and virulence.
CANNABIS AND DRIVING: A REVIEW OF CURRENT EVIDENCE

There is currently much debate in the road safety and wider communities concerning the extent to which licit and illicit drugs are a road safety problem. Cannabis is the most widely used illicit drug in Victoria, and is being used by a growing proportion of the population, particularly younger people. Contrary to data from the early to mid-1990s, recent Victorian crash data suggest that cannabis does elevate crash risk. It is therefore timely to draw together the international literature in regard to the issues around cannabis use and road safety. This paper is based on a report that is currently being prepared for the baseline sponsors of MUARC. The full report reviews the key issues concerning cannabis and road safety, including: patterns of cannabis use in the population; the prevalence of cannabis in the driver population, drivers suspected of driving under the influence, and drivers killed or injured; effects on simulator and on-road driving; detecting cannabis use in bodily samples; and measuring impairment using performance tests such as the Standardised Field Sobriety Test. The report highlights the current gaps in knowledge and documents the specific areas of research that need to be pursued in future studies in order to move closer to resolving the issue of whether (and how) cannabis influences driving skills. This paper summarises the key themes that emerge from the full report. (a) For the covering entry of this conference, please see ITRD abstract no. E206143.
Regional brain atrophy and aberrant cortical folding relate to anxiety and depression in patients with traumatic brain injury and psychogenic nonepileptic seizures

Psychogenic nonepileptic seizures (PNES) are characterized by multifocal and global abnormalities in brain function and connectivity. Only a few studies have examined neuroanatomic correlates of PNES. Traumatic brain injury (TBI) is reported in 83% of patients with PNES and may be a key component of PNES pathophysiology. In this study, we included patients with TBI preceding the onset of PNES (TBI‐PNES) and TBI without PNES (TBI‐only) to identify neuromorphometric abnormalities associated with PNES.
Comprehensive review on use of phospholipid based vesicles for phytoactive delivery

Abstract Plant-derived phytoconstituents are well known for their therapeutic potential. It has been experimentally demonstrated that whole-plant extract or isolated phytoconstituents reveal various therapeutic potentials like hepatoprotective, antimicrobial, neuroprotective, antitumor, antioxidant, skin protectives, etc. Although these phytoconstituents have potential therapeutic benefits, their use is limited due to their poor bioavailability, stability in biological fluids, and authentication issues. These continue to be an open problem that affects the application of these valuable ancient herbal herbs in the effective treatment and management of various disease conditions. A potential solution to these difficult problems could be the loading of phytoactives in phospholipid-based vesicular systems. Phospholipid-based vesicles like liposomes, phytosomes, ethosomes as well as transfersomes were effectively utilized recently to solve drawbacks and for effective delivery of phytoactives. Several landmark studies observed better therapeutic efficacy of phytoactive loaded vesicles compared to conventional drug delivery. Thus phospholipid-based vesicles mediated phytoactive delivery is a recently developed promising and attractive strategy for better therapeutic control on disease conditions. The present short review highlights recent advances in herbal bioactive loaded phospholipid-based vesicles.
Structural biofilm resistance of carbon‐infiltrated carbon nanotube coatings

Periprosthetic joint infection (PJI) is a devastating complication of orthopedic implant surgeries, such as total knee and hip arthroplasties. Treatment requires additional surgeries because antibiotics have limited efficacy due to biofilm formation and resistant bacterial strains such as methicillin‐resistant Staphylococcus aureus (MRSA). A non‐pharmaceutical approach is needed, and examples of this are found in nature; dragonfly and cicada wings are antibacterial because of their nanopillar surface structure rather than their chemistry. Carbon‐infiltrated carbon nanotube (CICNT) surfaces exhibit a similar nanopillar structure, and have been shown to facilitate osseointegration, and it is postulated that they might provide a structurally‐derived resistance to bacterial proliferation and biofilm formation. The objective of this study was to test the biofilm resistance of CICNT coatings. Two types of CICNT were produced: a vertically aligned CNT forest on a silicon substrate using a layer of iron as the catalyst (CICNT‐Si) and a random‐oriented CNT forest on stainless steel (SS) substrate using the substrate as the catalyst (CICNT‐SS). These were tested against SS and carbon controls. After 48 h in an MRSA biofilm reactor, samples demonstrated that both types of CICNT coatings significantly (p < 0.0001) reduced MRSA biofilm formation by 60%–80%. Morphologically, biofilm presence on both types of CICNT was also significantly reduced. Clinical Significance: Results suggest that a CICNT surface modification could be suitable and advantageous for medical devices susceptible to MRSA cell attachment and biofilm proliferation, particularly orthopedic implants.
Efferent Auditory Pathways Inhibition in Turner syndrome

ABSTRACT Purpose The goal of this study is to investigate the efferent auditory pathways inhibition in Turner's syndrome and to relate it to the cytogenetic profile. Methods This is a cross-sectional study with a comparison group. A sample with 94 participants divided into two groups: The study group was a sample of 40 patients diagnosed with Turner’s syndrome (17.6 years of age). The control group was composed of 54 volunteers (18.9 years of age), female, without syndrome. The selected individuals were submitted to efferent auditory pathways inhibition research. Results The mean of the inhibitory effect of the efferent auditory pathway in the study group in the right ear was 0.4 dB and in the comparison group it was 1.9 dB, however in the left ear the mean of the inhibitory effect of the efferent auditory pathway was 1.4 dB in the study group and 0.8 dB in the comparison group. The inhibitory effect of the efferent auditory pathway was present in 14 individuals with monosomy and in 15 with other cytogenetic alterations. Conclusions In the study group, the efferent auditory pathways inhibition value was significantly higher in the left ear and significantly lower than the control group in the right ear. There was no significant difference in efferent auditory pathways inhibition of right ear and left ear between the karyotype types.
Computed tomographic examination of the articular process joints of the cervical spine in warmblood horses: 86 cases (2015-2017).

OBJECTIVE To describe articular process joints (APJs) of the cervical spine in horses on the basis of CT and to determine whether abnormalities were associated with clinical signs. ANIMALS 86 client-owned warmblood horses. PROCEDURES Horses that underwent CT of the cervical spine between January 2015 and January 2017 were eligible for study inclusion. Medical records were reviewed for age, body weight, breed, sex, history, clinical signs, and CT findings. Horses were divided into 3 case groups and 1 control group on the basis of clinical signs. RESULTS 70 warmblood horses were cases, and 16 were controls. Abnormalities were more frequent from C5 through T1 and were severe in only horses from the case group. Narrowing of the intervertebral foramen was common in horses in the case group (85.7%), often owing to enlarged, misshaped articular processes, followed by degenerative changes, periarticular osteolysis, cyst-like lesions, and fragmentation. High articular process-to-vertebral body (C6) ratio (APBR) and high-grade narrowing of the intervertebral foramen and periarticular osteolysis were noted for horses with forelimb lameness or signs of cervical pain or stiffness. No association was identified between APBR and age or sex. An APBR > 1.5 was found in only horses in the case group, and 32.3% of APJs with APBRs > 1.5 did not have any degenerative changes and periarticular osteolysis. CONCLUSIONS AND CLINICAL RELEVANCE CT was useful to identify abnormalities of the APJs of the cervical spine. An association existed between CT findings and clinical signs. The APJs can be enlarged without concurrent degenerative changes.
Introduction to Matrix Factorization for Recommender Systems

Recommender systems aim to personalize the experience of user by suggesting items to the user based on the preferences of a user. The preferences are learned from the user’s interaction history or through explicit ratings that the user has given to the items. The system could be part of a retail website, an online bookstore, a movie rental service or an online education portal and so on. In this paper, I will focus on matrix factorization algorithms as applied to recommender systems and discuss the singular value decomposition, gradient descent-based matrix factorization and parallelizing matrix factorization for large scale applications.
Medical abortion ratios and gender equality in Europe: an ecological correlation study

Abstract Medical abortion (MA) is recommended by the WHO as a safe and effective pregnancy termination method in the first trimester. From a feminist perspective, it is a non-medicalised, self-managed, emancipating procedure allowing persons seeking abortion to be more in control of their abortion, as opposed to surgical procedures. In European countries where MA is legal, the proportion of MA (relative to surgical abortions) varies greatly. We hypothesised that this ratio may be partly explained by country-level dimensions of gender equality. We assessed the association between MA ratios and gender equality in Europe in correlation and regression analyses, using several country-level gender equality indices. The relevance of other factors, i.e. date of introduction of MA and pregnancy week until which MA is permitted, was also investigated. MA ratios ranged from 24.4% (Italy) to 97.7% (Finland). MA was more frequent relative to surgical abortion in countries with higher levels of gender equality. All gender equality indices were associated with MA ratios (e.g. Global Gender Gap Index corr. coeff: 0.761, p < 0.0001). Specifically, markers of economic and political gender equality seemed to drive the correlations. The pregnancy week until which MA is permitted was associated with both gender equality and MA ratios. Our study suggests that women’s participation in the economic and political sphere may have repercussions on the methods offered and used through abortion services. It highlights the link between feminist perspectives, reproductive health policies and practices, and gender equality, especially in terms of access to economic resources and political representation.
A Blockchain-Based Dynamic Consent Architecture to Support Clinical Genomic Data Sharing (ConsentChain): Proof-of-Concept Study

Background In clinical genomics, sharing of rare genetic disease information between genetic databases and laboratories is essential to determine the pathogenic significance of variants to enable the diagnosis of rare genetic diseases. Significant concerns regarding data governance and security have reduced this sharing in practice. Blockchain could provide a secure method for sharing genomic data between involved parties and thus help overcome some of these issues. Objective This study aims to contribute to the growing knowledge of the potential role of blockchain technology in supporting the sharing of clinical genomic data by describing blockchain-based dynamic consent architecture to support clinical genomic data sharing and provide a proof-of-concept implementation, called ConsentChain, for the architecture to explore its performance. Methods The ConsentChain requirements were captured from a patient forum to identify security and consent concerns. The ConsentChain was developed on the Ethereum platform, in which smart contracts were used to model the actions of patients, who may provide or withdraw consent to share their data; the data creator, who collects and stores patient data; and the data requester, who needs to query and access the patient data. A detailed analysis was undertaken of the ConsentChain performance as a function of the number of transactions processed by the system. Results We describe ConsentChain, a blockchain-based system that provides a web portal interface to support clinical genomic sharing. ConsentChain allows patients to grant or withdraw data requester access and allows data requesters to query and submit access to data stored in a secure off-chain database. We also developed an ontology model to represent patient consent elements into machine-readable codes to automate the consent and data access processes. Conclusions Blockchains and smart contracts can provide an efficient and scalable mechanism to support dynamic consent functionality and address some of the barriers that inhibit genomic data sharing. However, they are not a complete answer, and a number of issues still need to be addressed before such systems can be deployed in practice, particularly in relation to verifying user credentials.
The effect of substitutional doping of Yb2+ on structural, electronic, and optical properties of CsCaX 3 (X: Cl, Br, I) phosphors: a first-principles study

Using first-principles calculations, the effects of Yb2+ substitutional doping on structural, electronic, and optical properties of a series of perovskite compounds CsCaX 3 (X: Cl, Br, I), have been investigated. We employed generalized gradient approximation (GGA) and HSE hybrid functional to study the electronic and optical properties. A series of pristine CsCaX 3 (X: Cl, Br, I) is characterized as a non-magnetic insulator with indirect bandgap perovskite materials. These phosphor materials are suitable candidates for doping with lanthanide series elements to tune their electronic bandgaps according to our requirements because of their wide bandgaps. The calculated electronic bandgaps of CsCaX 3 (X: Cl, Br, I) are 3.7 eV (GGA) and 4.5 eV (HSE) for CsCaI3, 4.5 eV (GGA) and 5.3 eV (HSE) for CsCaBr3, and 5.4 eV (GGA) and 6.4 eV (HSE) for CsCaCl3. According to formation energies, the Yb2+ doped at the Ca-site is thermodynamically more stable as compared to all possible atomic sites. The electronic band structures show that the Yb2+ doping induces defective states within the bandgaps of pristine CsCaX 3 (X: Cl, Br, I). As a result, the Yb2+ doped CsCaX 3 (X: Cl, Br, I) become the direct bandgap semiconductors. The defective states above the valence band maximum are produced due to the f-orbital of the Yb atom. The impurity states near the conduction band minimum are induced due to the major contribution of d-orbital of the Yb atom and the minor contribution of s-orbital of the Cs atom. The real and imaginary parts of the dielectric function, optical reflectivity, electron energy loss spectrum, extinction coefficient, and refractive index of pristine and Yb2+ doped CsCaX 3 (X: Cl, Br, I) were studied. The optical dispersion results of dielectric susceptibility closely match their relevant electronic structure and align with previously reported theoretical and experimental data. We conclude that the Yb2+ doped CsCaX 3 (X: Cl, Br, I) are appealing candidates for optoelectronic devices.
Degradation of Pharmaceuticals Through Sequential Photon Absorption and Photoionization – the Case of Amiloride Derivatives

Photodegradation of pharmaceutical and agrochemical compounds is an important concern for health and the environment. Amiloride derivatives undergo clean photosubstitution in protic solvents. We have studied this apparent photo-SNAr reaction with a range of experimental and computational techniques. Available evidence points to a mechanism starting with photoexcitation followed by absorption of a second photon to eject an electron to give a radical cation intermediate. Subsequent substitution reaction with the protic solvent is assisted by a general base, possibly strengthened by the proximal solvated electron. Final recombination with the solvated electron generates the observed product. Quantum chemical computations reveal that excited state antiaromaticity is relieved when an electron is ejected from the photoexcited molecule by the second photon, leading to a weakly aromatic radical cation. The mechanism indicated here could have wide applicability to photoinduced degradation of similar heteroaromatic compounds in the environment as well as in protic solvents. There are also strong similarities to a class of increasingly popular synthetic photoredox methods.
Mitigating Denial of Service Attacks using Anonymity Networks: Relationship Anonymity-Communication Overhead Trade-off

Denial-of-service attacks are a significant threat to mission critical communication infrastructures, e.g., to industrial control systems. They are relatively easy to perpetrate, as an attacker that has access to communication links or equipment could observe the source and destination addresses for every message, and can identify and discard the messages exchanged between particular communication participants. Mix networks and anonymity networks could render these attacks more difficult by providing anonymous communication via relaying. Nevertheless, relaying introduces overhead and increases the end-to-end message delivery delay, which in practice must often be low. Hence, an important question is how to optimize anonymity for limited overhead and delay. In this paper we address this question by studying two anonymity networks: MCrowds, an extension of Crowds, which provides unbounded communication delay and Minstrels, which provides bounded communication delay. We derive exact and approximate analytical expressions for the relationship anonymity for these systems. Using MCrowds and Minstrels we show that, contrary to intuition, increased overhead does not always improve anonymity. We investigate the impact of the system's parameters on anonymity and on the optimal anonymity network parameters, and the sensitivity of anonymity to the misestimation of the number of attackers.
Economic Upper Bound Estimation in Hausdorff Distance Computation for Triangle Meshes

The Hausdorff distance is one of the most fundamental metrics for comparing 3D shapes. To compute the Hausdorff distance efficiently from a triangular mesh A$A$ to another triangular mesh B$B$ , one needs to cull the unnecessary triangles on A$A$ quickly. These triangles have no chance to improve the Hausdorff distance estimation, that is the parts with local upper bound smaller than the global lower bound. The local upper bound estimation should be tight, use fast distance computation, and involve a small number of triangles in B$B$ during the reduction phase for efficiency. In this paper, we propose to use point‐triangle distance, and only involve at most four triangles in B$B$ in the reduction phase. Comparing with the state‐of‐the‐art proposed by Tang et al. in 2009, which uses more costly triangle‐triangle distance and may involve a large number of triangles in reduction phase, our local upper bound estimation is faster, and with only a small impact on the tightness of the bound on error estimation. Such a more economic strategy boosts the overall performance significantly. Experiments on the Thingi10K dataset show that our method can achieve several (even over 20) times speedup on average. On a few models with different placements and resolutions, we show that close placement and large difference in resolution bring big challenges to Hausdorff distance computation, and explain why our method can achieve more significant speedup on challenging cases.
Building Services Handbook

Cold and hot water and supply systems heating systems storage of fuel ventilation systems air conditioning drainage systems soil and waste disposal systems flushing devices and sanitary appliances sewage disposal refuse disposal gas installations and service pipework gas meters and controls gas burners and flues oil firing electric wiring systems methods of electric wiring electrical installations for large buildings telephones and electric heating construction site electricity electric and supplementary lighting systems daylighting lifts and escalators ducts for engineering services automatic sprinkler systems hose reels and fire rinsers portable and fixed extinguishers fire detectors fire prevention in ductwork and smoke control.