Miracle-dz/UniFAR-FTUs huggingface dataset:
LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway

ABSTRACT LncRNA DDX11 antisense RNA 1 (DDX11-AS1) is recognized as having an imperative oncogenic role in different types of human cancer. Nevertheless, the functions, as well as the basic mechanisms of DDX11-AS1 in the EMT process of esophageal squamous cell carcinoma (ESCC), are yet to be clarified. In this research, high DDX11-AS1 expression was detected in ESCC cells as well as tissues and was linked to the poor prognosis of patients with ESCC. DDX11-AS1 promoted cell proliferation, migration, invasion ability and epithelial mesenchymal transition (EMT) process in vitro. Mechanistic analysis depicted that DDX11-AS1 may function as a ceRNA through sponging miR-30d-5p to upregulate the expression of SNAI1 and ZEB2. Meanwhile, overexpression of DDX11-AS1 might cause the activation of the Wnt/β-catenin signaling pathway via targeting miR-30d-5p. On the whole, the findings of this research illustrate that DDX11-AS1 may act as an EMT-related lncRNA to advance ESCC progression through sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and activate the Wnt/β-catenin pathway, which indicates that it might serve as a probable therapeutic target for ESCC.
At the Root of Nodule Organogenesis: Conserved Regulatory Pathways Recruited by Rhizobia

The interaction between legume plants and soil bacteria rhizobia results in the formation of new organs on the plant roots, symbiotic nodules, where rhizobia fix atmospheric nitrogen. Symbiotic nodules represent a perfect model to trace how the pre-existing regulatory pathways have been recruited and modified to control the development of evolutionary “new” organs. In particular, genes involved in the early stages of lateral root development have been co-opted to regulate nodule development. Other regulatory pathways, including the players of the KNOX-cytokinin module, the homologues of the miR172-AP2 module, and the players of the systemic response to nutrient availability, have also been recruited to a unique regulatory program effectively governing symbiotic nodule development. The role of the NIN transcription factor in the recruitment of such regulatory modules to nodulation is discussed in more details.
Identification of maximum road friction coefficient and optimal slip ratio based on road type recognition

The identification of maximum road friction coefficient and optimal slip ratio is crucial to vehicle dynamics and control. However, it is always not easy to identify the maximum road friction coefficient with high robustness and good adaptability to various vehicle operating conditions. The existing investigations on robust identification of maximum road friction coefficient are unsatisfactory. In this paper, an identification approach based on road type recognition is proposed for the robust identification of maximum road friction coefficient and optimal slip ratio. The instantaneous road friction coefficient is estimated through the recursive least square with a forgetting factor method based on the single wheel model, and the estimated road friction coefficient and slip ratio are grouped in a set of samples in a small time interval before the current time, which are updated with time progressing. The current road type is recognized by comparing the samples of the estimated road friction coefficient with the standard road friction coefficient of each typical road, and the minimum statistical error is used as the recognition principle to improve identification robustness. Once the road type is recognized, the maximum road friction coefficient and optimal slip ratio are determined. The numerical simulation tests are conducted on two typical road friction conditions(single-friction and joint-friction) by using CarSim software. The test results show that there is little identification error between the identified maximum road friction coefficient and the pre-set value in CarSim. The proposed identification method has good robustness performance to external disturbances and good adaptability to various vehicle operating conditions and road variations, and the identification results can be used for the adjustment of vehicle active safety control strategies.
Bioinformatic Analysis of Antiviral Medicinal Compounds Against Sars Cov-2 Proteases

The world is under siege from a global pandemic caused by a novel class of coronaviruses called severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). These viruses cause severe respiratory illness leading to death. Molecular studies reveal that SARS CoV-2 proteases are involved in the processing of viral polyproteins. This study was conducted to obtain antiviral agents for SARS CoV-2 proteases. An extensive library of antiviral medicinal compounds was scrutinized to determine the probable interaction with both main and 3-chymotrypsin like proteases. Six antiviral compounds (Abietic Acid, Gallic Acid, Piceatannol, Piperine, Sinomenine, and Triptolide) were capable of establishing hydrogen bonds with the active pocket residues of the viral proteases, with appreciable binding energy. These compounds were subjected to root mean square analysis and tested not only for acute toxicity, but also for absorption, distribution, metabolism, excretion, and toxicity properties. Results were favourable for use in the treatment of SARS COV-2 infection.
Improving the Efficiency of Wireless Sensor Networks through Signal Processing Techniques

 Abstract—- The minimization of energy consumption in modern technology has become a crucial element of research in engineering it is not only advantageous to realizing versatile, robust designs, but also the demand of an environmentally-awakened society. In the case of wireless networking, discovering energy-efficient solutions is just as important to the practicality and success of the technology as it is to commercialization and public reception. In this paper we show that a large portion of the beamforming gains can be realized even with imperfect synchronization corresponding to phase errors with reasonably large variance. We present a master-slave architecture where a designated master transmitter coordinates the synchronization of other (slave) transmitters for beamforming. We observe that the transmitters can achieve distributed beamforming with minimal coordination with the Base Station using channel reciprocity. Thus, inexpensive local coordination with a master transmitter makes the expensive communication with a distant Base Station receiver more efficient.
Correlation Between Biographical Reflection And Tolerance Of Ambiguity

Tolerance of ambiguity is most needed in unpredictable and difficult life situations, where one has to make decisions and life choices. However, the basis of the reflexive mechanism underlying this phenomenon is still undiscovered. Biographical reflection is a type of reflection one demonstrates when introspecting on one’s life events, where life choices have to be made. The study hypothesis is the assumption that biographical reflection is a predictor variable for tolerance of ambiguity. The sample consists of the data obtained from 250 people aged 18 to 45. The criteria measured were biographical reflection (Biographical Reflection Questionnaire or BRQ, by M.V. Klementyeva) and tolerance of ambiguity (The Multiple Stimulus Types Ambiguity Tolerance Scale, MSTAT, by D.L. MacLain, adjusted to the Russian context). The data obtained was analyzed using Pearson's correlation coefficient, Mann-Whitney U-test, and linear regression. The discovered correlation between biographical reflection and tolerance of ambiguity proves that people with stronger biographical reflection show better tolerance of ambiguity (p ≤ 0.01). Biographical reflection and tolerance of ambiguity decrease with aging: the respondents aged 35 and over reported a lower degree of biographical reflection (p = 0.001) and tolerance of ambiguity (p = 0.001). We have discovered that a higher degree of biographical reflection implied a higher MSTAT score (p = 0.001).
Development and Preliminary Validation of the Gender Inclusive Rape Myth Acceptance Scale

Rape myths are widespread and contribute to a rape culture that excuses and normalizes permissive attitudes surrounding rape and sexual assault. To combat rape culture and decrease sexual assault, many programs focus on reducing rape myth acceptance (RMA). To best assess outcomes of such prevention efforts, we must ensure we are accurately measuring this construct. Current RMA scales are decades old and focus almost exclusively on cisgender women. As such, they are outdated and leave out important experiences of cisgender men and gender diverse individuals. The Gender Inclusive Rape Myth Acceptance Scale (GIRMA) was developed to address such limitations in current measures. Two studies were completed to develop and establish preliminary validation of the GIRMA. Study One included 614 adults in the United States, recruited through Amazon's Mechanical Turk; Study Two included 414 adults in the United States, recruited in the same way. An exploratory factor analysis was conducted with an original pool of 73 items that included myths about the experiences of cisgender women, cisgender men, transgender, and gender diverse individuals. Parallel analysis indicated a single factor structure for measuring rape myths. A confirmatory factor analysis was conducted for Study Two, which supported the single-factor approach. These analyses resulted in a concise, robust, inclusive 18-item scale to measure rape myths. Model fit was excellent, as was reliability. Additionally, construct validity was supported through examining the relationship between the GIRMA and previously validated RMA and sexism scales. The GIRMA offers researchers the ability to fully assess the construct of rape myths in a short, psychometrically sound manner. Future research is needed to investigate the reliability of the GIRMA in other populations.
Human-friendly robotic manipulators: Safety and performance issues in controller design

Recent advances in robotics have spurred its adoption into new application areas such as medical, rescue, transportation, logistics, personal care and entertainment. In the personal care domain, robots are expected to operate in human-present environments and provide non-critical assistance. Successful and flourishing deployment of such robots present different opportunities as well as challenges. Under a national research project, Bobbie, this dissertation analyzes challenges associated with these robots and proposes solutions for identified problems. The thesis begins by highlighting the important safety concern and presenting a comprehensive overview of safety issues in a typical domestic robot system. By using functional safety concept, the overall safety of the complex robotic system was analyzed through subsystem level safety issues. Safety regions in the world model of the perception subsystem, dependable understanding of the unstructured environment via fusion of sensory subsystems, lightweight and compliant design of mechanical components, passivity based control system and quantitative metrics used to assert safety are some important points discussed in the safety review. The main research focus of this work is on controller design of robotic manipulators against two conflicting requirements: motion performance and safety. Human-friendly manipulators used on domestic robots exhibit a lightweight design and demand a stable operation with a compliant behavior injected via a passivity based impedance controller. Effective motion based manipulation using such a controller requires a highly stiff behavior while important safety requirements are achieved with compliant behaviors. On the basis of this intuitive observation, this research identifies suitable metrics to identify the appropriate impedance for a given performance and safety requirement. This thesis also introduces a domestic robot design that adopts a modular design approach to minimize complexity, cost and development time. On the basis of functional modularity concept where each module has a unique functional contribution in the system, the robot “Bobbie-UT” is built as an interconnection of interchangeable mobile platform, torso, robotic arm and humanoid head components. Implementation of necessary functional and safety requirements, design of interfaces and development of suitable software architecture are also discussed with the design.
Implementation of Advanced Product Quality Planning in Engineering Project

Engineering Design (ED) process is the foundation on which Automobile Engineering students currently base their project work. Though efficient in addressing the primary academic requirements, it is nevertheless open ended and hence the methodology for project execution will differ from team to team. ED at higher semesters, in the author's perspective, is less structured and feel there is a need for a defined industrial methodology based on ED, especially to address the needs of automobile engineering students. This requirement can be fulfilled by Advanced Product Quality Planning (APQP), a framework of procedures and techniques followed by the automotive industry worldwide. An attempt was made to implement APQP on experimental basis in a project titled Solar Array Electric Vehicle. The following four stages were incorporated in the project: Plan and Define Program, Product Design and Development, Feedback and Corrective actions and Control Plan Methodology. This paper highlights the scope, implementation methodology and results of application of APQP in Solar Array Electric Vehicle project.
ALWAYS : a system for wafer yield analysis : report and user's manual

An interactive cnvironmenl for the analysis of yield infonmation necded on modem integratcd circuit manufacturing lines is prcsented. The system is ahlc to quantify wafer yiclds, yield variations betwccn wafers and within the wafers themselves, yields of wafer hatchcs, yield variations between batclles, to idemify clusters in wafers and or in lots, and is also able to predict wafer yields via simple simulation tools. The analysis technique investigates the effect of correlated and uncorrelated sourccs of yield loss. Such infonmation can be used to study the changes in thc technological proccss. Graphical displays in the fonn of wafer maps arc used to represent the spatial distrihution of dice in the wafer. Facilities such as radial and angular distribution analyses, among others, arc provided to examine data, and hypothetical wafer maps arc created to visualise and predict simulated wafer yields.
Real-time maximum power point tracking for grid-connected photovoltaic systems

The paper presents a model-based method for photovoltaic array maximum power point prediction. The method was tested successfully on a small grid-connected PV system. A three-phase IGBT-voltage-source inverter is used as the power conditioner and a DSP-controller is employed to perform real-time control and prediction functions. The system and experimental results obtained are presented in the paper.
Isolation, Structure Determination of Sesquiterpenes from Neurolaena lobata and Their Antiproliferative, Cell Cycle Arrest-Inducing and Anti-Invasive Properties against Human Cervical Tumor Cells

Seven new germacranolides (1–3, 5–8), among them a heterodimer (7), and known germacranolide (4), eudesmane (9) and isodaucane (10) sesquiterpenes were isolated from the aerial parts of Neurolaena lobata. Their structures were determined by using a combination of different spectroscopic methods, including HR-ESIMS and 1D and 2D NMR techniques supported by DFT-NMR calculations. The enantiomeric purity of the new compounds was investigated by chiral HPLC analysis, while their absolute configurations were determined by TDDFT-ECD and OR calculations. Due to the conformationally flexible macrocycles and difficulties in assigning the relative configuration, 13C and 1H NMR chemical shift and ECD and OR calculations were performed on several stereoisomers of two derivatives. The isolated compounds (1–10) were shown to have noteworthy antiproliferative activities against three human cervical tumor cell line with different HPV status (HeLa, SiHa and C33A). Additionally, lobatolide C (6) exhibited substantial antiproliferative properties, antimigratory effect, and it induced cell cycle disturbance in SiHa cells.
Research on Target Localization Method of CRTS-III Slab Ballastless Track Plate Based on Machine Vision

In the construction of high-speed railway infrastructure, a CRTS-III slab ballastless track plate has been widely used. Anchor sealing is an essential step in the production of track plates. We design a novel automated platform based on industrial robots with vision guidance to improve the automation of a predominantly human-powered anchor sealing station. This paper proposes a precise and efficient target localization method for large and high-resolution images to obtain accurate target position information. To accurately update the robot’s work path and reduce idle waiting time, this paper proposes a low-cost and easily configurable visual localization system based on dual monocular cameras, which realizes the acquisition of track plate position information and the correction of position deviation in the robot coordinate system. We evaluate the repeatable positioning accuracy and the temporal performance of the visual localization system in a real production environment. The results show that the repeatable positioning accuracy of this localization system in the robot coordinate system can reach ±0.150 mm in the x- and y-directions and ±0.120° in the rotation angle. Moreover, this system completes two 18-megapixel image acquisitions, and the whole process takes around 570 ms to meet real production needs.
Validation of TG07 and TG13/TG18 criteria for acute cholangitis and predictors of in-hospital mortality in patients over 80 years old

Aim of the study This study aims to validate Tokyo guidelines (TG) TG07/TG13/TG18 criteria and identify predictors of in-hospital mortality in acute cholangitis (AC) patients over 80 years old. Material and methods This is a retrospective audit of AC patients from January 2009 to December 2016. Demographic, clinical, investigation, management, and mortality data were studied. Multinomial logistic regression analysis with stepwise variable selection identified predictors for in-hospital mortality. Results Three hundred and eighty-eight patients were treated for AC. One hundred and sixty-two (41.8%) patients were male. 230 (59.3%) patients had a history of biliary disease, 161 (41.5%) patients had type 2 diabetes mellitus (T2DM), and 98 (25.3%) patients had ischaemic heart disease (IHD). Abdominal pain (n = 226, 58.2%), pyrexia (n = 247, 63.7%), and vomiting (n = 159, 41.0%) were the common presenting symptoms. 191 (49.2%) patients had abdominal tenderness. Positive blood cultures were recorded in patients 158 (40.7%) patients. Escherichia coli was the most commonly identified organism (n = 117, 30.2%). 77 (19.8%), 188 (48.5%) and 123 (31.7%) patients were graded with mild, moderate, and severe AC, respectively. 30-day, 90-day, and in-hospital mortality were 9 (2.3%), 19 (4.9%) and 38 (9.8%), respectively. On multivariate analysis, systolic blood pressure ≤ 100 mmHg (OR = 3.817, 95% CI: 1.365-10.761, p = 0.011), hypoalbuminaemia < 28 gm/l (OR = 6.052, 95% CI: 2.635-13.904, p < 0.001), serum creatinine ≥ 176.8 (OR = 2.787, 95% CI: 1.146-6.778, p = 0.024) and international normalized ratio (INR) > 1.5 (OR = 3.247, 95% CI: 1.234-8.544, p = 0.017) were independent predictors of in-hospital mortality. Conclusions Hypotension, hypoalbuminaemia, elevated creatinine, and elevated INR predict in-hospital mortality in AC patients over 80 years old.
Comprehensive silicon solar cell computer modeling. Quarterly progress report No. 1, January 5, 1984-April 4, 1984

The general method to solve the transport equations for a solar cell is discussed. To obtain an accurate representation of a physical system, the system geometry is divided into a number of segments (mesh points). In a one-dimensional geometry, the segments are defined by a series of parallel planes. The separation of the planes defining the segments determines the simulation accuracy. The segments may be taken as thin as required to obtain the accuracy desired. The transport equations, governing the behavior of the physical system, are applied to each segment, and a closed-form solution is obtained in each of the segments. A brief discussion is presented of some of the phenomena submodels in the model and the representations used in the simulation program. The submodels cover such phenomena as mobility, diffusivities, boundary conditions at depletion region edges and those imposed at the mesh points, bandgap narrowing and intrinsic concentration, carrier lifetime, induced surface electric field, and built-in fields. (LEW)
Characterization of Cobalt-Based Stellite 6 Alloy Coating Fabricated by Laser-Engineered Net Shaping (LENS)

The results of microstructure and mechanical properties evaluation of a Stellite 6 (Co-6) alloy deposited on X22CrMoV12-1 substrate by the laser-engineered net shaping (LENSTM) technology are presented in this paper. The Stellite 6 alloy is widely used in industry due to its excellent wear resistance at elevated temperatures and corrosive environments. Specific properties of this alloy are useful in many applications, e.g., as protective coatings in steam turbine components. In this area, the main problems are related to the fabrication of coatings on complex-shaped parts, the low metallurgical quality of obtained coatings, and its insufficient adhesion to a substrate. The results of recently performed investigations proved that the LENS technology is one of the most effective manufacturing techniques of the Co-6 alloy coatings (especially deposited on complex-shaped turbine parts). The microstructural and phase analyses of obtained Stellite 6 coatings were carried out by light microscopy techniques and X-ray diffraction analysis. A chemical homogeneity of Co-6 based layers and a fluctuation of chemical composition in coating–substrate zone after the laser deposition were analyzed using an energy dispersive X-ray spectrometer coupled with scanning electron microscopy. The room temperature strength and ductility of the LENS processed layers were determined in static bending tests.
InAs/GaAs p-i-p quantum dots-in-a-well infrared photodetectors operating beyond 200 K

High-temperature operating performance of p-i-p quantum dots-in-awell infrared photodetectors (QDIPs) is successfully demonstrated. The optically active region consists of 10 layers of p-doped selfassembled InAs quantum dots (QDs) asymmetrically positioned in In0.15Ga0. 85As quantum wells (QWs). The dark current is suppressed by an incorporated superlattice (SL) structure composed of 10 pairs of AlGaAs/GaAs heterostructure. The very low recorded dark current makes the fabricated p-i-p QDIPs suitable for high-temperature operation. The measured photoresponse reveals broad mid-wave infrared (MWIR) detection up to 200 K.