Miracle-dz/UniFAR-FTUs huggingface dataset:
Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: a cross-sectional investigation

Abstract Introduction: Higher physical activity (PA) and lower sedentary behaviour (SB) levels have demonstrated beneficial effects on temporal summation (TS) and conditioned pain modulation (CPM) in healthy adults. This cross-sectional study investigated the relationships between PA and SB and TS/CPM responses in individuals with chronic musculoskeletal pain. Methods: Sixty-seven middle-aged and older adults with chronic musculoskeletal pain were recruited from the community. Questionnaires measuring demographics, pain, and psychological measures were completed. Physical activity/SB levels were measured using the International Physical Activity Questionnaire—short form and Sedentary Behaviour Questionnaire, respectively. Semmes monofilament was used to assess mechanical TS (MTS) at the most symptomatic (MTS-S) and a reference region (MTS-R); change in the pain scores (baseline-10th application) was used for analysis. Conditioned pain modulation procedure involved suprathreshold pressure pain threshold (PPT-pain4) administered before and after (CPM30sec, CPM60sec, and CPM90sec) conditioning stimulus (2 minutes; ∼12°C cold bath immersion). For analysis, PPT-pain4 (%) change scores were used. Results: PPT-pain4 (%) change scores at CPM30sec and CPM60sec demonstrated significant weak positive correlations with SB levels and weak negative correlations with PA measures. After adjusting for confounding variables, a significant positive association was found between SB (h/d) and PPT-pain4 (%) change scores at CPM30sec and CPM60sec. No significant associations between MTS and PA/SB measures. Conclusion: Sedentariness is associated with higher pain inhibitory capacity in people with chronic musculoskeletal pain. The observed relationship may be characteristic of a protective (sedentary) behaviour to enhance pain modulatory mechanism. Prospective longitudinal studies using objective PA/SB measures are required to validate the observed relationship in a larger sample size.
Economic analysis of oral posaconazole prophylaxis in acute myeloid leukemia during remission induction in Turkey

OBJECTIVE: Invasive fungal infections (IFI) are important and trending causes of mortality in patients with acute leukemia, especially during the remission induction. METHODS: In this study, 225 patients who were diagnosed with acute myeloid leukemia (AML) and undergoing intensive treatment for remission induction were enrolled in a retrospective manner. RESULTS: Within the whole group, which consisted of 225 patients, 90 patients received prophylactic antifungal treatment (PAT) (40%), while 135 patients did not (60%) receive. The mean cost of hospitalization was 9.151,6 (2.872,6–20.483,3) US dollars. Gender distribution and mean ages of groups were similar. One hundred fourteen patients not on PAT (84.4%) and five patients on PAT (5.5%) received intravenous antifungal treatment. Thirty-two of the patients who were not on PAT (23.7%) and 11 of the patients on PAT died during remission induction (12.22%). The mean day of the hospitalization was 22.61 days for the patients on PAT and 33.89 days for the patients who were not on PAT. In patients on PAT, the mean number of transfused platelet units was six (0–9), while 12.51 (4–43) units for patients who were not on PAT. CONCLUSION: In our study, the oral suspension form of posaconazole was observed to be cost-effective to prevent IFI with a significant decrease in mortality during remission induction treatment.
Segmentifier : interactively refining clickstream data into actionable segments

Clickstream data has the potential to provide actionable insights into e-commerce consumer behavior, but previous techniques fall short of handling the scale and complexity of real-world datasets. We present Segmentifier, a novel visual analytics interface that supports an iterative process of refining collections of action sequences into meaningful segments that are suitable for downstream analysis with techniques that require relatively small and clean input. We also present task and data abstractions for the application domain of clickstream data analysis, leading to a framework that abstracts the segment analysis process in terms of six functions: view, refine, record, export, abandon, and conclude. The Segmentifier interface is simple to use for analysts operating under tight time constraints. It supports filtering and partitioning through visual queries for both quantitative attributes and custom sequences of events, which are aggregated according to a three-level hierarchy. It features a rich set of views that show the underlying raw sequence details and the derived data of segment attributes, and a detailed glyph-based visual history of the automatically recorded analysis process showing the provenance of each segment in terms of an analysis path of attribute constraints. We demonstrate the effectiveness of our approach through a usage scenario with real-world data and a case study documenting the insights gained by an e-commerce analyst.
Wives’ perception of sexual relationship with narcissistic men: Results of a qualitative thematic analysis with Iranian women

Background and aims: Many studies have investigated the interpersonal dimensions of narcissism, though women’s perceptions of sexual relationship with a narcissistic individual have rarely been the topic of interest. The main purpose of this study was to investigate the sexual lived experiences of women living with narcissistic men. Methods: To this end, a qualitative thematic analysis was used to have a better understanding of the concept. A total of 31 women were selected through convenience sampling technique and were interviewed using a semi-structured interview, all of whom were living with their narcissistic husbands. All interviews were recorded, transcribed, and analyzed by thematic analysis. Results: Based on the findings of this study, two main themes emerged during data analysis. First, women found their sexual relationship with a narcissistic man insecure, as well as the perception that their relationship was one-sided and demanding. In addition, the insecured relationship comprised several subthemes including the lack of sexual intimacy, sexual aggression and unwanted sex, and low commitment. The other main themes contained two sub-themes, namely, unrealistic and excessive expectations from the spouse and the relationship and the lack of responsibility and cooperation of the husband. Conclusion: This study was mainly focused on sexuality in living with a narcissistic person and the results showed that sex is strongly influenced by the consequences of narcissism. This study also has some research and clinical implications for future research.
The Effect of Light Massage on Hemodynamic in Patients with Heart Failure - A Systematic Review

: Massage is a general body skin stimulation, centered on the back and shoulders, or can be done on one or several parts of the body and performed about 10 minutes of each part of the body to achieve maximum relaxation results. Light Massage (soft touch) is the basis of massage therapy and also combines science and art. Determining the exact amount of pressure for each person and finding the area of tension and other soft tissue problems can use a sense of touch. Touch also conveys caring, an important component in relation to healing. The purpose of this systematic review is to determine the effect of light massage on hemodynamic changes in heart failure pati ents. The article search was done on 7 data base to answer the purpose of this review. From some articles that have been reviewed can be said that massage massage massage therapy is one good alternative choice in stabilizing hemodynamic patients with heart failure. While to conclude massage therapy massage light is one of the best alternatives requires a lot of random clinical studies that compare light massage with various other therapies.
Accidental guidewire migration following emergency femoral central venous catheterization

Central venous catheter placement especially the femoral venous catheter is a common practice in critically ill patients. Awareness of potential complications of the guidewire such as guidewire migration is of utmost importance. Though potentially retrievable by a vascular surgeon or interventional radiologist if it occurs, close supervision by a senior person during passage by a junior or inexperienced person, the use of ultrasound before and after placement of catheter, and use of a checklist may help to identify and prevent its occurrence. We present a very rare complication of central venous cannulation of a guidewire migration in our institution. A 12-year-old girl presented to the Paediatric Emergency Unit (PEU) with status epilepticus and aspiration pneumonia and subsequently transferred to the Paediatric Intensive Care Unit (PICU) for ventilatory support. She had accidental guidewire migration to the left internal jugular vein following a right transfemoral central venous catheterization. She underwent successful guidewire retrieval via a right groin incision.
Relation of viscous lidocaine combined with propofol deep sedation during elective upper gastrointestinal endoscopy to discharge

Abstract Fusing topical pharyngeal anesthetics (TPAs) to intravenous sedation during esophagogastroduodenoscopy (EGD) has been controversial. This double-blind, randomized, placebo-controlled trial assessed the association of TPA with patient recovery time, post-EGD to discharge. Supplementary aims were to determine the association of TPA with patient and practitioner satisfaction (both measured on a 100-mm visual analog scale), total propofol dose, and side effects. The study included 93 patients (mean age 53.8 years, range 44–67; 37 men and 56 women) undergoing elective EGD at a single academic medical center from September 2015 to October 2016. Urgent or therapeutic EGDs were excluded. Interventions were 7.5 mL 2% lidocaine viscous solution and 7.5 mL placebo solution (3% methylcellulose). There were no statistically significant differences between the lidocaine (n = 46) and placebo (n = 47) groups with respect to recovery time (42 ± 17.8 vs 39 ± 15.9 minutes; P = 0.23), procedure time (6.5 ± 2.7 vs 7 ± 3.6 minutes; P = 0.77), endoscopist satisfaction (83.2 ± 24.4 vs 77 ± 27.7, P = 0.23), patient discomfort (16.6 ± 19.8 vs 24.0 ± 29.7, P = 0.37), or total propofol administered (2.3 ± 1.3 vs 2.3 ± 1.0 mg/kg, P = 0.55). Compared to placebo, topical viscous lidocaine does not appear to delay recovery time or adversely affect sedation-related outcomes.
A review on Machine Learning Techniques for Neurological disorders estimation by Analyzing EEG Waves

With the fast improvement of neuroimaging data acquisition strategies, there has been a significant growth in learning neurological disorders among data mining and machine learning communities. Neurological disorders are the ones that impact the central nervous system (including the human brain) and also include over 600 disorders ranging from brain aneurysm to epilepsy. Every year, based on World Health Organization (WHO), neurological disorders affect much more than one billion people worldwide and count for up to seven million deaths. Hence, useful investigation of neurological disorders is actually of great value. The vast majority of datasets useful for diagnosis of neurological disorders like electroencephalogram (EEG) are actually complicated and poses challenges that are many for data mining and machine learning algorithms due to their increased dimensionality, non stationarity, and non linearity. Hence, an better feature representation is actually key to an effective suite of data mining and machine learning algorithms in the examination of neurological disorders. With this exploration, we use a well defined EEG dataset to train as well as test out models. A preprocessing stage is actually used to extend, arrange and manipulate the framework of free data sets to the needs of ours for better training and tests results. Several techniques are used by us to enhance system accuracy. This particular paper concentrates on dealing with above pointed out difficulties and appropriately analyzes different EEG signals that would in turn help us to boost the procedure of feature extraction and enhance the accuracy in classification. Along with acknowledging above issues, this particular paper proposes a framework that would be useful in
Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

Background: Recent studies indicate that aerobic training may aﬀect non-alcoholic fatty liver disease (NAFLD). Besides, vitamin D and NAFLD are known to have more than just an association. Objectives: This study aimed to examine the eﬀects of vitamin D supplementation, combined with aerobic training, on anthropometric indices in elderly women with NAFLD and vitamin D deﬁciency. Methods: Werandomlydivided40elderlywomenwithNAFLDandvitaminDdeﬁciencyintofourgroups: aerobictraining+vitamin Dsupplementation(AT+Vit. D),aerobictraining(AT),vitaminDsupplementation(Vit. D),andcontrol(C). TheATprotocolconsisted of 40-60minutesof aerobictrainingat60% -75% of HR max threetimesaweekforeightweeks. Theanthropometricindicesincluded bodyweight(BW),bodymassindex(BMI),bodyfatpercentage(BFP),andwaist-hipratio(WHR)measuredatthestartandaftereight weeksof thestudy. Datawereanalyzedbypaired t -testandANOVAusingSPSSversion21. 0softwareatasigniﬁcancelevelof P< 0.05. Results: Anthropometric indices (BW, BMI, BFP, and WHR) signiﬁcantly changed in all groups, with a signiﬁcant increment in the controlgroupanddecrementintheAT+Vit. D,AT,andVit. Dgroups. NosigniﬁcantdiﬀerenceswereobservedbetweentheAT+Vit. D, AT, and Vit. D groups in the measured variables. Conclusions: VitaminDsupplementationcombinedwithaerobictrainingimprovestheanthropometricindicesinelderlywomen with NAFLD.
Young people’s beliefs about psychological therapy for psychosis: a Q-Methodological study

Abstract Background: The evidence base for the use of psychological therapies in the treatment of psychosis is growing, however engagement can be difficult and outcomes are variable. Beliefs, attitudes and expectations may have an important influence on whether individuals engage with therapy and on clinical outcomes, however, these beliefs have not been adequately explored. Aims: To examine what young people in Early Intervention Services (EIS) think about psychological therapies for psychosis. Method: Thirty participants were recruited from EIS across five NHS trusts to examine young people’s beliefs about psychological therapy. Results: Four distinct factors, or sets of beliefs, about therapy emerged: (1) Therapy is helpful and gives hope for the future; (2) Therapy is just talking, people need medication; (3) Therapy is useful but stigmatising; (4) Therapy is better than medication. Positive views towards different aspects of therapy were present in all four accounts. Other important issues were raised, including concerns about stigma and opposing beliefs about medication. Conclusion: These four factors provide useful insights into young people’s beliefs about psychological therapy. Individuals’ beliefs and expectations should be recognised and explored in order to promote greater engagement in and better outcomes from therapy.
Evaluation of an infused alcohol and drug prevention programme

Purpose Alcohol, tobacco, marijuana and other drugs use typically increases in prevalence and frequency during middle and late adolescence. School health instruction often focusses on providing facts and rarely provides tools for addressing the psychosocial risk factors needed to prevent substance use. The purpose of this paper is to report about the effectiveness of a prevention programme delivered in US high school health classes. The intervention augments typical instruction by providing teachers with activities that can be infused in their daily teaching. Design/methodology/approach In total, 26 schools were randomly assigned to receive the intervention or serve as controls. Pupils were pretested near the beginning of the school year, posttest near the end of the school year and administered a final test near the beginning of the following school year. Teachers in treatment schools were provided with activities designed to target psychosocial variables known to mediate substance use onset and self-initiated cessation. These include normative beliefs, intentionality, lifestyle incongruence, beliefs about consequences of use, peer pressure resistance skills, decision-making skills, goal setting skills and stress management skills. Findings Hierarchical modelling analytic strategies revealed the intervention to have definable positive impacts on alcohol and cigarette use. Moreover, the intervention had strongest effects on alcohol and cigarette use among pupils who were identified at pretest as being lower-than-average risk. Originality/value This research provides support for providing teachers with a strategy for preventing alcohol, tobacco and other drugs that can be used in a flexible manner to augment the instruction they are already mandated to provide.
The Effect of Cooking Method on the Glycemic Index of Kalat Rice

Background: Rice is considered a major source of carbohydrates in most parts of Iran and many other countries. The quality of carbohydratesexpressedasglycemicindex(GI)hasbeenknowntoplayakeyroleinchronicdiseasessuchasdiabetes,cardiovascular problemsandevencancer. DeterminingtheGIof diﬀerenttypesof riceandtheeﬀectof cookingmethodsonthisindexistherefore crucial. Objectives: The present study was conducted to determine the eﬀects of two diﬀerent cooking methods on the GI of Kalat rice as a popular rice in Iran. Methods: Ten healthy male participants with similar activity levels, i.e. no exercise, were recruited from Mashhad University of medical Sciences, Mashhad, Iran. The participants consumed the test meal, steamed rice and boiled rice each in a diﬀerent day. Blood glucose levels were measured at the time points of -5, 0, 30, 60, 90 and 120 minutes. Repeated measures ANOVA was used to analyze the data. Results: The GIs of boiled and steamed Kalat rice were respectively found to be 89.4 and 89.2, suggesting no signiﬁcant diﬀerences. Moreover, the glycemic loads (GLs) of boiled and steamed Kalat rice were respectively found to be 23.01 and 23.87. The GI and GL of Kalat rice were therefore high compared to those of other types of Iranian rice. Conclusions: Cutting down on Kalat rice is beneﬁcial, speciﬁcally in individuals at risk for developing chronic diseases.
The Prevalence and Pattern of Non-Medical Use of Prescription Drugs in Abakaliki, Southeast, Nigeria

Introduction: The growing of non-medical use of prescription drugs is a global health problem and it has emerged as a particularly dangerous health-behavior among young people. However studies assessing misuse among people in Abakaliki are non-existent. Aim: To determine the prevalence and pattern of non-medical use of prescription drugs in Abakaliki. Materials and method: This was a cross-sectional study that involved 420 participants. The respondents completed an anonymous, self-administered questionnaire assessing past-year prevalence and pattern of non-medical use of five classes of prescription drugs. The data was analyzed using SPSS version 20. Results: The prevalence of non-medical use of prescription drugs in this study was 38.3%. The mean age of the participants was 22.2 ± 3.8 years with majority of them (38.3%) being within the 19-25 years age bracket. The majority of participants were males (52.1%) whereas female accounted for 47.9% of the respondents. Pain medications such as tramadol, codeine and morphine accounted for majority (73.8%) of unprescribed medication abused by the respondents. This is followed by other medications such as ibuprofen which was 45%. Sleeping medications and stimulants accounted for 28.3% and 27.4% of unprescribed drugs respectively. Similarly, pain medication accounted for majority (74.8%) of prescribed medicines used by the participants for non medicinal purposes. The least abused class of drugs in the prescribed category were sedative/anxiety medications which accounted for just over 18%. To relax or relieve tension is the most common reasons (20.5%) for use of drugs for non medical purposes reported in this study. Other reasons include to improve concentration (16.7%), to get high (10.7%) and for recreation (6.9%). Conclusion: This study shows high prevalence of non medical use of prescription drugs among our study participants in Abakaliki.
Safety assessment of the process AMB, based on Bandera technology, used to recycle post‐consumer PET into food contact materials

Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) evaluated the safety of the recycling process AMB (EU register number RECYC154). The input is washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers with no more than 5% PET from non‐food applications. It is decontaminated in a reactor at high temperature under vacuum and extruded to sheets. Having examined the challenge test provided, the Panel concluded that two steps, the decontamination in the vacuum reactor (step 2) and the extrusion (step 3), are critical in determining the decontamination efficiency of the process. The operating parameters to control the performance of these critical steps are temperature, residence time and pressure for step 2 and temperature, residence time, pressure and screw speed for step 3. It was demonstrated that this recycling process is able to ensure that the level of migration of potential unknown contaminants into food is below the conservatively modelled migration of 0.1 μg/kg food. Therefore, the Panel concluded that the recycled PET obtained from this process when used up to 100% for the manufacture of materials and articles for contact with all types of foodstuffs for long‐term storage at room temperature, with or without hotfill, is not considered of safety concern. Articles made of this recycled PET are not intended to be used in microwave and conventional ovens and such use is not covered by this evaluation.