Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Big Five Personality and Reward on Work Performance of Operational Unit Employees with Job Satisfaction as a Mediating Variable at PT. KAI Daop VI Yogyakarta

This study aims to examine and analyze: (1) the influence of the big five personality, reward, job satisfaction on work performance, (2) the influence of the big five personality on job satisfaction, (3) the effect of reward on job satisfaction, (4) job satisfaction in mediating the influence of the big five personality on work performance, (5) job satisfaction in mediating the effect of rewards on employee work performance. The sample in this study were operational employees at PT. KAI DAOP VI Yogyakarta as many as 200 people. Data collection was done by using a questionnaire. The data were analyzed using the Smart PLS 3.27 program and the SPSS version 28.00 program. The results of the study show that the big five personalities, especially conscientiousness and openness to experience, have a significant effect on employee work performance. The reward, both extrinsic and intrinsic rewards have a significant effect on employee work performance. Big five personality, only extraversion and neuroticism have a significant effect on employee job satisfaction. Reward (extrinsic and intrinsic) has a significant effect on job satisfaction. Job satisfaction was only proven to significantly mediate the effect of neuroticism on employee work performance. Job satisfaction has been shown to significantly mediate the effect of rewards (extrinsic and intrinsic) on the work performance of operational employees at PT. KAI DAOP VI Yogyakarta.
Connected Aircraft Squadron Electrocardiographic Sign (Yasser Sign); An Index for Tachypnea in Specific T-Wave Abnormalities- A New Diagnostic, Therapeutic, and Prognostic Sign; Retrospective-Observational Study

Background: Tachypnea is a well-known clinical symptom. Specific electrocardiographic T-wave changes during tachypnea are a crucial point in the decision. The new sign is a constellation of the Twaves changes in special leads. There are three types were prescribed. The types have classified either base on an interaction between lead I and II, or aVL and aVR or V1 and V2. Hyperventilation syndrome, left bundle branch block, left ventricular strain, and Wolff-Parkinson-White syndrome was common inducers.
A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity

Simple Summary The use of small compounds in cancer immunotherapy has been limited so far. Her we screen for drugs that enhanced the ability of immune cells to kill tumor cells and identified the molecule Colistin Sulfate as a booster of immune activity. Abstract Due to their crucial role in tumor immunity, NK cells have quickly became a prime target for immunotherapies, with the adoptive transfer of NK cells and the use of NK cell engagers quickly moving to the clinical stage. On the other hand, only a few studies have focused on small molecule drugs capable of unleashing NK cells against cancer. In this context, repurposing small molecules is an attractive strategy to identify new immunotherapies from already approved drugs. Here, we developed a new platform to screen small molecule compounds based on a high-throughput luciferase-release cytotoxicity assay. We tested 1200 FDA approved drugs from the Prestwick Chemical Library, to identify compounds that increase NK cells’ cytotoxic potential. We found that the antibiotic colistin sulfate increased the cytotoxicity of human NK cells towards cancer cells. The effect of colistin was short lived and was not observed when NK cells were pretreated with the drug, showing how NK cell activity was potentiated only when the compound was present at the time of recognition of cancer cells. Further studies are needed to uncover the mechanism of action and the pre-clinical efficacy of colistin sulfate in mouse cancer models.
Immigration and rates of entrepreneurship in large US communities

ABSTRACT Using US county-level data from the Business Information Tracking System, we revisit the influence of immigrants on business start-ups. We find that a higher density of foreign-born immigrants has a positive impact on new business formation, but the relationship varies by the ethnic background of the immigrants and by industry type. Specifically, Caucasian immigrants, and to a lesser extent Asians, drive the positive relationship. Higher concentrations of Latinx immigrants, however, have either no or a predominantly negative influence on business start-up rates. The largely positive relationship between foreign-born and entrepreneurship varies significantly across different industries, particularly for Asians and Latinx. Care must be taken when making broad generalizations about the immigrant and entrepreneurship relationship. Specifically, there are significant variations across ethnic backgrounds and types of industries.
An Enhancement of Power Quality With Efficient Active Power Transfer Capability in a PV–BSS-Fed UAPF for Microgrid Realization

This article investigates the enhancement of power quality with an efficient active power transfer capability in a universal active power filter (UAPF) integrated with a photovoltaic (PV) and battery storage system (BSS). The UAPF operates as a bidirectional interface between the PV–BSS and point of interconnection for microgrid realization. A new control strategy is proposed to extract fast and accurate voltage and current reference signals to operate the system in a desired manner. Here, the extraction of load voltages and calculation of load and reference powers are used to generate the reference signals, thereby comparing with actual signals with hysteresis controller to produce switching pulses of converters. As a result, the shunt and series converters form a robust system by acting as a current-controlled voltage source and voltage-controlled current source, respectively. It eliminates the need for adaptive filters and low-pass filters to extract the fundamental component of the load current. Furthermore, it increases the conversion efficiency of converters and improves the static and dynamic performance of the system. The proposed system is developed with a 1-kVA prototype laboratory setup using a field-programmable gate array controller and extensively tested with various test conditions such as grid voltage fluctuations, nonlinear and imbalanced load, and change in irradiance.
Alternariol ameliorates lung carcinoma via reprogramming cytokine signaling associated with PI3K/Akt cascade in vitro and in vivo

Objectives The lung cancer is most frequently diagnosed cancer incidence worldwide. A large number of populations are heavily affected to this every year with poor prognosis. Methods Our study investigated the anticancer effect of alternariol, a secondary metabolite, on A549 lung cancer cell line and benzo-α-pyrene induced lung carcinoma model on balb/c mice. The cytotoxicity assay, DAPI staining and the flow cytometry was performed to assess the anticancer efficacy of alternariol in A549 lung cancer cell. For in vivo study the toxicity study was performed. The lung cancer was developed in the animals via intraperitoneal administration of benzo-α-pyrene and subsequently 2 weeks later alternariol treatment was carried out for 24 weeks. The chemotherapeutic effect of alternariol was assessed through histopathological analysis, followed by immunohistochemistry and in vivo antioxidant study. Results The in vitro data suggested a significant percentage of early and late apoptotic events in A549 cells with G0/G1 phase arrest which ultimately caused apoptosis followed by alternariol therapy. The in vivo study showed that alternariol therapy decreased the pulmonary fibrosis and formation of granuloma in lung tissue and restored the normal histopathological characteristics of lung. Furthermore, alternariol treatment downregulated the expression of PI3K, Akt and inflammatory mediators such as IL-6, TNF-α and increased the expression of apoptotic markers, p53. Conclusion In conclusion, the treatment with alternariol effectively decreased the progression of lung cancer through the inhibition of carcinogenic markers by reprogramming the p53/PI3K/Akt pathway and IL-6/TNF-α mediated cytokine signaling in mice.
Critical Requirements for the Initiation of a Cardiac Arrhythmia in Rat Ventricle: How Many Myocytes?

Cardiovascular disease is the leading cause of death worldwide due in a large part to arrhythmia. In order to understand how calcium dynamics play a role in arrhythmogenesis, normal and dysfunctional Ca2+ signaling in a subcellular, cellular, and tissued level is examined using cardiac ventricular myocytes at a high temporal and spatial resolution using multiscale computational modeling. Ca2+ sparks underlie normal excitation–contraction coupling. However, under pathological conditions, Ca2+ sparks can combine to form Ca2+ waves. These propagating elevations of (Ca2+)i can activate an inward Na+–Ca2+ exchanger current (INCX) that contributes to early after-depolarization (EADs) and delayed after-depolarizations (DADs). However, how cellular currents lead to full depolarization of the myocardium and how they initiate extra systoles is still not fully understood. This study explores how many myocytes must be entrained to initiate arrhythmogenic depolarizations in biophysically detailed computational models. The model presented here suggests that only a small number of myocytes must activate in order to trigger an arrhythmogenic propagating action potential. These conditions were examined in 1-D, 2-D, and 3-D considering heart geometry. The depolarization of only a few hundred ventricular myocytes is required to trigger an ectopic depolarization. The number decreases under disease conditions such as heart failure. Furthermore, in geometrically restricted parts of the heart such as the thin muscle strands found in the trabeculae and papillary muscle, the number of cells needed to trigger a propagating depolarization falls even further to less than ten myocytes.
The Signal‐to‐Noise Paradox in ENSO Prediction: Role of ENSO Growth Rate and Period

This paper investigates the relationship between heterogeneous predictability and homogeneous predictability for El Niño‐Southern Oscillation (ENSO) prediction. Previous studies showed that a larger heterogeneous predictability than homogeneous predictability, referred as the signal‐to‐noise paradox, is caused by a higher persistence in the observations than in the model. By using the recharge oscillator model, it is found analytically and numerically that both ENSO growth rate and period contribute to this paradox. A larger ENSO growth rate in the observation can lead to a higher persistence and heterogeneous predictability. However, a larger ENSO growth rate associated with a shortened ENSO period can also lead to this paradox although the persistence of the observation is lower than forecast model. Finally, we apply it to explain the paradox after 1960 is caused by a larger ENSO growth rate and a shortened ENSO period.
Low Back Pain—A Disease or Condition of Impaired Functional Health? Definition-Inherent Consequences for the Comprehensive Care of Back Pain Patients

This article provides arguments for and against the classification of low back pain (LBP) as a disease or health condition. Based on the basic definitions of health, disease, illness, sickness, infirmity, and pain, little support has been found for the idea that LBP represents a specific disease entity. Although specified back pains do not signify disease, the pain experienced may be caused by specific diseases, such as inflammation, neuropathy, fractures, or tumors. Common findings in medical imaging indicate disk herniation, degenerative joints with or without signs of inflammation in the facet joints, and spinal stenosis present in a relatively high proportion of pain-free persons. The same applies to hypomobile segmental dysfunction (joint blockage) and myofascial syndrome. Both functional entities play a core role in manual medicine but are common in asymptomatic subjects, showing low–moderate reliability and failing to meet the classification requirements of disease. Reducing disability through interventions targeting a disease’s structural/functional conditions cannot be achieved since the relationship between pathological changes and activity restrictions/participation is indirect in most cases. Considering LBP as a condition shifts the goal of treatment from the disease to the patient’s optimal performance in activities/participation and allows them to be self-determined and independent.
Safety Control Design With Flight Envelope Protection and Reference Command Generation

When confronting different levels of aircraft actuator faults, a safety control system without considering the postfault performance degradation raises the probability of flight incidents. This article presents a safety control scheme against actuator malfunctions, on the basis of flight envelope protection and reference command regeneration. First, with respect to a high-fidelity aircraft model, a flight envelope estimation method is developed to respect to the state limits of postfault aircraft (i.e., trim and maneuvering envelopes). Simultaneously, in an attempt to alleviate the burden of the damaged actuators, a degraded reference command is online regenerated, thus, maintaining the closed-loop aircraft within the safe flight envelope. Second, a sliding mode control scheme with the integration of a prescribed performance function is proposed to track the degraded reference command. When comparing to the existing control schemes, the gap between safety control and reference command regeneration is bridged to ameliorate practical flight safety. Finally, comparative simulation studies, based on the high-fidelity Boeing 747 longitudinal model, are conducted to examine the effectiveness of the proposed scheme.
Creating and Sustaining Service Industry Relationships and Families: Theorizing How Personal Workplace Relationships Both Build Community and Perpetuate Organizational Violence

Service industry workers experience challenging labor conditions in the United States, including pay below the minimum wage, expected emotional labor, and harassment. Additionally, in part because they work long shifts in high stress environments in restaurants and bars, many build and form personal workplace relationships (PWRs). In 2021, we interviewed 38 service industry workers and managers during the COVID-19 pandemic where we examined occupational challenges they faced in the state of Texas, USA. Through our interpretive research, this essay showcases our inductive findings on how service industry workers and managers utilize communication to create and sustain PWRs. We identified how some PWRs are sustained through a unique form of occupational identification that cultivates a “service industry family”, which we term familial personal workplace relationships (familial PWRs). This extends past organizational communication scholarship on family to consider occupational identification. Furthermore, our research reveals that while PWRs may build communities through care and support, they also perpetuate organizational violence, like sexual harassment and bullying.
High gain wideband and multi-band on-demand reconfigurable antenna for modern wireless application

Abstract This paper proposes a wide band and multiband frequency reconfigurable antenna that can operate in the UWB, GSM, GPS, 4G LTE, WLAN, and WiMAX bands. The antenna is made up of a trapezoidal-shaped monopole radiator, which was inspired by a rectangular monopole antenna. The ground plane is modified by embedding T and L-shaped slots to notch the desired operating frequency. The proposed antenna can switch to six different frequencies using RF PIN diodes, making it suitable for modern wireless applications. A multilayer frequency selective surface (FSS) reflector is presented to improve the gain of the proposed reconfigurable antenna. The low-profile design achieved a significant increase in gain while retaining the UWB antenna's excellent impedance bandwidth. Because of the use of the FSS reflector, the antenna's average peak gain has increased from 6 to 10.4 dBi. The proposed antenna has a wide switching capability, which validates its unique feasibility for high-speed multiple Internet of Things applications via a common embedded platform under various applications.
Genetic analysis of leaf trichome density using mixed major gene plus polygene inheritance model in Brassica rapa ssp. chinensis

ABSTRACT Leaf trichome is an important trait for stress-resistance breeding in Brassica crops, but its scientific evaluation and identification are rarely reported. To investigate the inheritance of leaf trichome in non-heading Chinese cabbage, two inbred lines, ‘14XS23W’ (glabrous) and ‘14XS23Y’ (hirsute), were used to generate F1 and F2 populations for joint analysis using a mixed major genes plus polygene inheritance model. The density of adaxial leaf trichomes was controlled by two pairs of additive-dominance-epistasis major genes plus additive-dominance polygenes. The broad-sense heritabilities of the major genes were 93.8% and 85.51%, respectively, for greenhouse and open-field conditions. However, the density of the abaxial leaf trichome was controlled by two pairs of additive-dominance-epistasis major genes plus additive dominance-epistasis polygenes. The broad-sense heritabilities of the major genes were 91.45% and 72.20%, while the polygenes were 0% and 14.5%, respectively, for greenhouse and open field environments. These results indicated that trichome density in non-heading Chinese cabbage was primarily controlled by two pairs of major genes with high heritability, implying that this trait is suitable for rapid selection in early generations.
Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for Pancreatic Cancer

Background Pancreatic cancer (PC) is a malignant tumor of the digestive tract. It presents with atypical clinical symptoms and lacks specific diagnostic indicators. This study is aimed at exploring the potential biomarkers of PC. Methods TCGA database pancreatic cancer dataset was normalized and used to identify differentially expressed genes (DEGs). Survival, independent prognostic, and clinical correlation analyses were performed on DEGs to screen for key genes. DNA methylation, mutation, and copy number variation (CNV) analyses were used to analyze genetic variants in key genes. GSEA was performed to explore the functional enrichment of the key genes. Based on the expression of key genes, construction of a competing endogenous RNA (ceRNA) network, analysis of the tumor microenvironment (TME), and prediction of chemotherapeutic drug sensitivity were performed. Furthermore, the GEO database was used to validate the reliability of key genes. Results Two key genes (ECT2 and COL17A1) were identified, which were highly expressed in PC. The mRNA expression of ECT2 and COL17A1 was associated with DNA methylation and CNV. The cell cycle, proteasome, and pathways in cancer were enriched in the high-COL17A1 and ECT2 groups. The TME results showed that immune scores were decreased in the high-ECT2 group. CeRNA network results showed that there were eleven miRNAs were involved in the regulation of ECT2 and COL17A1. Moreover, pRRophetic analysis showed that 20 chemotherapeutic drugs were associated with ECT2 and COL17A1 expression. Conclusions Collectively, ECT2 and COL17A1 may be potential biomarkers for PC, providing a new direction for clinical diagnosis and treatment.
Power Allocation and Equivalent Transmit FDA Beamspace for 5G mmWave NOMA Networks: Meta-Heuristic Optimization Approach

Most of the existing works in millimeter wave (mmWave) and non-orthogonal multiple access (NOMA) communications (mmWave NOMA) employs phased array (PA) antennas which yield only angle beamspace without range dependent, range-interference suppression and “dot-shaped” array resolution. In this paper, we propose a collocated transmitter (Tx) - receiver (Rx) mmWave NOMA system where frequency diverse array (FDA) antennas are utilized. FDA employs small frequency increments across the element indices which yields angle-range dependent beamspace. Herein, an equivalent radiate beamspace is designed to serve the users. Further, to ensure user equity, we formulate objective function to max-min achievable sum rate subject to power allocation and BS equivalent FDA transmit beamspace along the users. Since the problem is not convex, a boundary-compressed Bat meta-heuristic optimization algorithm is devised to provide a sub-optimal solution by optimizing the frequency increments to synthesis the BS beamspace along the users. The achievable secrecy rate, cost efficiency (CE), economic efficiency (ECE), and secrecy energy efficiency (SEE) are derived for the users. Both theoretical analysis and simulation results indicate that the proposed scheme would constitute an excellent nominee for 5G mmWave NOMA communication applications.
Anti-Inflammatory Mechanisms of Total Flavonoids from Mosla scabra against Influenza A Virus-Induced Pneumonia by Integrating Network Pharmacology and Experimental Verification

Influenza virus is one of the most common infectious pathogens that could cause high morbidity and mortality in humans. However, the occurrence of drug resistance and serious complications extremely complicated the clinic therapy. Mosla scabra is a natural medicinal plant used for treating various lung and gastrointestinal diseases, including viral infection, cough, chronic obstructive pulmonary disease, acute gastroenteritis, and diarrhoea. But the therapeutic effects of this herbal medicine had not been expounded clearly. In this study, a network pharmacology approach was employed to investigate the protective mechanism of total flavonoids from M. scabra (MSTF) against influenza A virus- (IAV-) induced acute lung damage and inflammation. The active compounds of MSTF were analyzed by LC-MS/MS and then evaluated according to their oral bioavailability and drug-likeness index. The potential targets of each active compound in MSTF were identified by using PharmMapper Server, whereas the potential genes involved in IAV infection were obtained from GeneGards. The results showed that luteoloside, apigenin, kaempherol, luteolin, mosloflavone I, and mosloflavone II were the main bioactive compounds found in MSTF. Primarily, 23 genes were identified as the targets of those five active compounds, which contributed to the inactivation of chemical carcinogenesis ROS, lipid and atherosclerosis, MAPK signaling pathway, pathways in cancer, PI3K-AKT signaling pathway, proteoglycans in cancer, and viral carcinogenesis. Finally, the animal experiments validated that MSTF improved IAV-induced acute lung inflammation via inhibiting MAPK, PI3K-AKT, and oxidant stress pathways. Therefore, our study demonstrated the potential inhibition of MSTF on viral pneumonia in mice and provided a strategy to characterize the molecular mechanism of traditional Chinese medicine by a combinative method using network pharmacology and experimental validation.