Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Modulator of the Renin–Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation

The monoester alkaloids in Aconitum carmichaelii, including benzoylaconitine (BAC), benzoylmesaconine, and benzoylhypaconitine, were found to have anti-hypertensive effects in spontaneously hypertension rats (SHRs), of which BAC is the strongest. However, its antihypertensive target and underlying molecular mechanisms remain unclear. In this study, first, we screened the antihypertensive targets of BAC by using the CVDPlatform (www.cbligand.org/CVD) and found that ACE/ACE2 are the most possible targets. Then, we verified the effect of BAC on ACE/ACE2 by virtual docking, SPR, enzyme activity assay, and HUVECs cell experiment. We found that BAC could bind with ACE/ACE2, inhibit ACE activity and protein expression, and activate ACE2 enzyme activity. Using vascular function test in vitro, we found that BAC could target ACE/ACE2 to enhance endothelium-dependent vasorelaxation. In BAC-treated SHRs, the levels of ACE and AngII in serum were reduced while Ang (1–7) was increased significantly, and the expression of ACE was reduced, which suggested that BAC can inhibit ACE and activate ACE2 to inhibit AngI to AngII and promote AngII to Ang (1–7) to inhibit vasoconstriction and finally attenuate hypertension. Furthermore, the signaling pathways with regard to vasorelaxation and vascular inflammation were investigated. The results showed that BAC could significantly activate Akt/eNOS, increase NO production, and promote endothelial-related vasodilation; BAC could also reduce inflammatory factors TNF-α and IL6, inhibition of COX-2 expression, and IKB-α phosphorylation to reduce vascular inflammation in SHRs. In brief, BAC targets ACE/ACE2 to enhance endothelium-dependent vasorelaxation and reduce vascular inflammation to attenuate hypertension as a potential modulator of the renin–angiotensin system.
Effect of 3-Month Aerobic Dance on Hippocampal Volume and Cognition in Elderly People With Amnestic Mild Cognitive Impairment: A Randomized Controlled Trial

As an intermediate state between normal aging and dementia, mild cognitive impairment (MCI), especially amnestic MCI (aMCI), is a key stage in the prevention and intervention of Alzheimer’s disease (AD). Whether dancing could increase the hippocampal volume of seniors with aMCI remains debatable. The aim of this study was to investigate the influence of aerobic dance on hippocampal volume and cognition after 3 months of aerobic dance in older adults with aMCI. In this randomized controlled trial, 68 elderly people with aMCI were randomized to either the aerobic dance group or the control group using a 1:1 allocation ratio. Ultimately, 62 of 68 participants completed this study, and the MRI data of 54 participants were included. A specially designed aerobic dance routine was performed by the dance group three times per week for 3 months, and all participants received monthly healthcare education after inclusion. MRI with a 3.0T MRI scanner and cognitive assessments were performed before and after intervention. High-resolution three-dimensional (3D) T1-weighted anatomical images were acquired for the analysis of hippocampal volume. A total of 35 participants (mean age: 71.51 ± 6.62 years) were randomized into the aerobic dance group and 33 participants (mean age: 69.82 ± 7.74 years) into the control group. A multiple linear regression model was used to detect the association between intervention and the difference of hippocampal volumes as well as the change of cognitive scores at baseline and after 3 months. The intervention group showed greater right hippocampal volume (β [95% CI]: 0.379 [0.117, 0.488], p = 0.002) and total hippocampal volume (β [95% CI]: 0.344 [0.082, 0.446], p = 0.005) compared to the control group. No significant association of age or gender was found with unilateral or global hippocampal volume. There was a correlation between episodic memory and intervention, as the intervention group showed a higher Wechsler Memory Scale-Revised Logical Memory (WMS-RLM) score (β [95% CI]: 0.326 [1.005, 6.773], p = 0.009). Furthermore, an increase in age may cause a decrease in the Mini-Mental State Examination (MMSE) score (β [95% CI]: −0.366 [−0.151, −0.034], p = 0.002). In conclusion, 3 months of aerobic dance could increase the right and total hippocampal volumes and improve episodic memory in elderly persons with aMCI. Clinical Trial Registration: This study was registered on the Chinese Clinical Trial Registry [www.chictr. org.cn], identifier [ChiCTR-INR-15007420].
The Negative Effects of Feces-Associated Microorganisms on the Fitness of the Stored Product Mite Tyrophagus putrescentiae

Feces have been suggested as a major source of microorganisms for recolonization of the gut of stored product mites via coprophagy. The mites can host microorganisms that decrease their fitness, but their transmission is not known. To address the role of fecal microbiota on mite fitness, we performed an experimental study in which the surfaces of mite (Tyrophagus putrescentiae) eggs were sterilized. Mites eggs (15 per experimental box) were then hatched and grown on feedstock with and without feces. These experiments were conducted with four distinct T. putrescentiae populations (5L, 5K, 5N, and 5P), and mite population density after 21 day of cultivation was used to assess mite fitness and the impact of fecal microbiota on fitness. Population density was not affected by the presence of feces in two of the cultures (5L and 5K), while significant effects of feces were observed in the other cultures (5N and 5P). Mite culture microbial communities were analyzed using cultivation-independent next-generation amplicon sequencing of microbial 16S and 18S ribosomal RNA (rRNA) genes in the fitness influenced populations (5N and 5P). Several microbial taxa were associated with fecal treatments and reduced mite fitness, including Staphylococcus and Bartonella-like bacteria, and the fungal genera Yamadazyma, Candida, and Aspergillus. Although coprophagy is the transmission route mites used to obtain beneficial gut bacteria such as Bartonella-like organisms, the results of this study demonstrate that fecal-associated microorganisms can have negative effects on some populations of T. putrescentiae fitness, and this may counteract the positive effects of gut symbiont acquisition.
Disjunction and Vicariance Between East and West Asia: A Case Study on Euonymus sect. Uniloculares Based on Plastid Genome Analysis

Scientists have long been captivated by biogeographic disjunctions, and disjunctions between East Asia and North America have been particularly well-studied at the genus and family levels. By contrast, disjunctions between eastern and western Asia have received less attention. Euonymus L. is taxonomically divided into two sections based on the number of cells in anthers as follows: E. sect. Uniloculares has one-celled anthers and occurs mainly in Asia, whereas E. sect. Biloculares has two-celled anthers and is distributed globally. We used Illumina sequencing to investigate the genomes of four species in sect. Uniloculares. The chloroplast (cp) genomes are highly conserved (157,290–158,094 bp). Pseudogenisation of ndhF and intron loss in rps16 was detected. Based on the cp genomes of the four species of E. sect. Uniloculares, we propose a novel hypothesis of disjunction between eastern and western Asia. Biogeographic reconstruction and molecular dating revealed that sect. Uniloculares separated from its sect. Biloculares forebears 4.0 Mya during the Pliocene era. The radial diversification of sect. Uniloculares from East Asia and the establishment of the western Asian clade during the Pleistocene era (1.9 Mya) were the results of both dispersal and vicariance, making the section the youngest diverged clade conforming to age estimation. The centre of origin of sect. Uniloculares was determined to be in East Asia. Disjunctions and diversification between eastern and western Asia in sect. Uniloculares are thought to have been caused by changes in monsoon patterns, temperature variations, and the emergence of the Gobi Desert.
Research on New Platform and Underwater Oil Storage for Marginal Oil Field Development

To address the issues of the exorbitant cost problem of many independent shallow marginal oil field development in Bohai sea,the concept of mobile multi-function simple offshore platform was proposed through technical demonstration.The design and optimization of oil-gas replacement of underwater mat oil storage was applied and analysis of economic benefit and bearing ability of risk was established by using internal rate of return and sensitivity analysis combining the break-even analysis.The new platform has been used in the project development of BZ3-2,which is proved to be more effective and has greater application prospects compared to the economic benefit of Qikou,Weizhou and Panyu project.
evelopment and Evaluation of a New Measure for Muscle one of Ankle Plantar Flexors: The Ankle Plantar Flexors one Scale

Objective: To develop and evaluate the reliability and conurrent validity of a clinically feasible measure for muscle tone f the ankle plantar flexors. Design: Cross-sectional reliability and validity study of the nkle Plantar Flexors Tone Scale. Setting: Department of rehabilitation in a general hospital. Participants: Patients (N 74) with cerebrovascular disease. Interventions: Not applicable. Main Outcome Measures: Muscle tone of the ankle plantar exors was measured using the Ankle Plantar Flexors Tone Scale, the odified Ashworth Scale (MAS), quality of muscle reaction with the odified Tardieu Scale, and passive resistive joint torque with a andheld dynamometer. Intrarater and interrater reliabilities were ssessed using the Cohen kappa coefficient ( ). Internal consistency as assessed using the Cronbach alpha ( ). Concurrent validity was ssessed with the Spearman rank correlation coefficient ( ). Results: The Ankle Plantar Flexors Tone Scale included 3 tems: stretch reflex, middle range resistance, and final range esistance. Intrarater and interrater reliabilities and internal conistency of the Ankle Plantar Flexors Tone Scale showed moderte to excellent agreement ( .63–.94; .81). Concurrent vaidity of the Ankle Plantar Flexors Tone Scale was low to very igh among the 3 items of the Ankle Plantar Flexors Tone Scale nd existing measures. The Spearman rank correlation coefficient howed high to very high correlation between stretch reflex and uality of muscle reaction as indices of the central component . 85–. 94). Middle range resistance and final range resistance as ndices of the peripheral component had low to moderate correation with passive resistive joint torque using a handheld dynaometer and MAS ( .44–.68). Conclusions: The Ankle Plantar Flexors Tone Scale allows easurement of ankle plantar flexor tone in greater detail than xisting subjective measures and provides a reliable and valid ethod for research and clinical use. Key Word: Rehabilitation. © 2009 by the American Congress of Rehabilitation edicine
Do Employee Trust and Job Satisfaction Mediate the Relationship of Leadership Styles and Emotional Intelligence with Project Success?

The current study investigates the impact of Leadership Styles (LS) and Emotional Intelligence (EI) on Project Success (PS) through underlying mediating mechanism of Job Satisfaction (JS) and trust. Total 160 responses were received from the team leaders (project managers, project leaders, project coordinators) of the NGOs sector of Pakistan. The findings of the research show that the relationship of LS and EI have significantly positive impact on the PS. Further, JS and Trust is positively and significantly influencing the PS and mediate the relationship of both LS and EI with PS. Within leadership styles, transactional leadership and Laissez Faire leadership styles have positive relationship with PS. However, the negative relationship of transformational leadership with PS is somewhat surprising as this relationship was expected to be positive. The findings suggest that project managers in NGOs must be aware of the impact of certain leadership behaviors and level of emotional intelligence for completing the projects successfully.
A Morpho-Semantic Digital Didactic Dictionary for Learners of Latin at Early Stages

Diccionario Didáctico Digital de Latín (Digital Didactic Dictionary for Latin) is an open-access lexicographic work, created and hosted by the Universidad Complutense de Madrid. It is a bilingual dictionary (Latin-Spanish) that faces the challenge of providing Spanish-speaking students of Latin with an innovative lexicographic tool that facilitates the learning of basic Latin. Based on the theoretical principles of valences described in Tesnière's Dependency Grammar, Lyons’ ontologies, and Fillmore's theory of semantic frameworks, the dictionary has been conceived as a linguistic tool to understand how Latin works at the semantic, morphological, and syntactic levels. It is a qualitative dictionary created ad hoc, used as an auxiliary tool to answer linguistic questions raised by an inductive didactic methodology that makes the Latin learning-teaching process available even to those students who lack basic syntactic knowledge. A structure of Hierarchical Faceted Categories that constitutes the lexicographic model provides various ways to access the lemmatised lexicon, facilitating intuitive navigation through the dictionary.
Disruptive Innovation in the Middle Eastern FinTech Sector: Resource-Based View

Building on prior suggestions concerning corporate resources as causes of disruptive innovation for increasing competitive advantage in developed economies, this research empirically re-investigated such assumptions in emerging markets. Through the theoretical lens of the resource-based perspective, the current research examined the perceived impacts of four different corporate resources (Financial, Human, Organizational, and Technological capital resources) on disruptive innovation that subsequently leads to increasing competitive advantage. A mixed-method design was utilized. The first study followed a quantitative approach (surveys; n= 154), whereas the second study followed a qualitative design (interviews; n= 16). Both studies targeted two different FinTech summits in the Middle East. This research delivered a new perspective and understanding concerning how Middle Eastern FinTechs perceive capital resources as causes of disruptive innovation for increasing competitive advantage.
Algorithm for demodulation of MPSK signals based on cyclostationary

A new algorithm is proposed for demodulation of MPSK signals.This method analyzes the cyclostationary of pretreated signals.In order to realize quadrature demodulation,the 4th-order cyclic cumulant is used to estimate carrier frequency and phase deviation.Because cyclic higher-order statistics can depress stationary noise,higher estimated accuracy can be obtained.Wavelet transform is used to estimate code rate.Through judgement sampling,blind demodulation is realized.This method doesn’t require prior information of received MPSK signals.Theoretical analysis and practical signal processing justify the efficiency of the new demodulation algorithm.
Investigate the impact of user’s state on the quality of authentication by keystroke dynamic

One of the most important issues in the field of information security has been and remains the issue a reliable user’s authentication. A special place among the possible authentication methods today is occupied by behavioural biometrics, which have a high degree of reliability. A keystroke dynamic, as a type of behavioural biometrics, is also capable of providing a high level of protection of information systems in the case of correctly selected characteristics. This article shows that external factors, including the psychophysiological state of a person, can also influence the authentication process by keystroke dynamics. In the paper, the state of the user was assessed in the process of collecting a sample of keystroke dynamics and a conclusion was made about the presence of such an influence.
OpenPubSub: Supporting Large Semantic Content Spaces in Peer-to-Peer Publish/Subscribe Systems for the Internet of Multimedia Things

The decentralized and highly scalable nature of structured peer-to-peer networks, based on distributed hash tables (DHTs), makes them a great fit for facilitating the interaction and exchange of information between dynamic and geographically dispersed autonomous entities. The recent emergence of multimedia-based services and applications in the Internet of Things (IoT) has led to a noticeable shift in the type of data traffic generated by sensing devices from structured textual and numerical content to unstructured and bulky multimedia content. The wide semantic spectrum of human recognizable concepts that can be stemmed from multimedia data, e.g., video and audio, introduces a very large semantic content space. The scale of the content space poses a semantic boundary between data consumers and producers in large-scale peer-to-peer publish/subscribe systems. The exact-match query model of DHTs falls short when participants use different terms to describe the same semantic concepts. In this work, we present OpenPubSub, a peer-to-peer content-based approximate semantic publish/subscribe system. We propose a hybrid event routing model that combines rendezvous routing and gossiping over a structured peer-to-peer network. The network is built on the basis of a high-dimensional semantic vector space as opposed to conventional logical key spaces. We propose methods to partition the space, construct a semantic DHT via bootstrapping, perform approximate semantic lookup operations, and cluster nodes based on their shared interests. Results show that for an approximate event matching upper bound recall of 56.7%, rendezvous-based routing achieves up to 54% recall while decreasing the messaging overhead by 44%, whereas, the hybrid routing approach achieves up to 43.8% recall while decreasing the messaging overhead by 59%.
Domiciliary Use of Chlorhexidine vs. Postbiotic Gels in Patients with Peri-Implant Mucositis: A Split-Mouth Randomized Clinical Trial

Peri-implant mucositis is a pathological condition characterized by an inflammatory process in the peri-implant soft tissues. Progression to peri-implantitis takes place in case of peri-implant bone resorption. Recently, an aid for non-surgical treatment by mechanical debridement (SRP) has been identified in probiotics. As there are no recent studies regarding their use for peri-implant mucositis, the aim of this study was to test a new postbiotic gel for this clinical condition. A split-mouth randomized clinical trial was performed. Twenty patients undergoing SRP were randomly assigned to two treatments based on the following oral gels: chlorhexidine-based Curasept Periodontal Gel (Group 1) and postbiotic-based Biorepair Parodontgel Intensive (Group 2). At baseline (T0) and after three (T1) and six (T2) months, the following peri-implant mucositis indexes were recorded: Probing Pocket Depth (PPD), Plaque Index (PI), Gingival Bleeding Index (GBI), Bleeding Score (BS), Marginal Mucosal Condition (MMC). A significant decrease is reported for both postbiotic and chlorhexidine for all peri-implant mucositis indices studied. Quite the opposite, no significant variation was present in intergroup comparisons. Greater improvements for BS, GBI and MMC inflammatory indices of the postbiotic gel compared to chlorhexidine suggest the importance of further studies to investigate the relevance of the product alone.
Estimation of Greenhouse Gas Emissions from Remote Sensing and Field Data in the Wari-Maro Forest Reserve and Its Periphery (Benin)

Land use affects the structure and functioning of forest ecosystems, thus affecting greenhouse gas fluxes. Greenhouse gas emissions (Carbon Dioxide, Methane and Nitrous Oxide) were assessed in the Wari-Maro Forest Reserve (FCWM) and its periphery between 2005 and 2020. To achieve this, the methodological approach applied is based on the use of activity data (AD) from 2005 and 2020 land use and land cover maps derived from satellite images and emission factors (EF) from forest inventory data conducted in 2005 and 2020. The analysis of the results shows that the peripheral zone has the highest emission factor evaluated at 87.22 t.eq-CO2 /ha/year against 47.37 t.eq-CO2/ha/year recorded in the Forest Reserve. The total Carbon Dioxide (CO2) emissions due to deforestation in the Forest Reserve are 5106.78 t.eq-CO2/ha/year against a global emission of 65402.23 t.eq-CO2/ha/year for the periphery. This high emission of the peripheral area is the result of the high anthropogenic pressure in this area. Those due to degradation are 2880.53 t.eq-CO2/ha/year in the Forest Reserve against 1049.67 t.eq-CO2/ha/year in the periphery. This strong emission of the forest reserve is due to the destruction of the vegetation notably the dense forests and the gallery forests. The amount of Methane (CH4) and Nitrous Oxide (N2O) increases progressively from the Forest Reserve (319.49 t.eq-CO2/ha/year and 26.80 t.eqCO2/ha/year) to the periphery (2658.08 t.eq-CO2ha/year and 222.99 t.eq-CO2/ha/year) probably due to the extent of agricultural and livestock production activities in this area.
Study on variable density perforating model of two-phase flow in horizontal wells

On consideration of the characteristics of gas-liquid two-phase stratified flow in horizontal wells and the non-Darcy effect which was caused by high speed gas-liquid two-phase flow through the perforation, an optimization perforating model with variable density of two-phase flow was established on the basis of the inflow model to the well and the gas-liquid stratified flow model in horizontal wells. The gas-liquid two-phase stratified flow law was revealed and the sensitivity of production and permeability was analyzed by numerical calculation. The results show that uniform perforating results in the increase of inflow at the heel of horizontal well. The horizontal well production profile can be controlled efficiently by means of perforation density adjustment especially in high permeability reservoir. The water and gas cone can be mitigated and the development benefit of oilfield can be increased through variable density perforating.
An SLP Vectorization Method Based on Equivalent Extended Transformation

SIMD extensions provide an efficient energy consumption platform to support mobile systems. How to use SIMD instructions to improve program performance is a challenge. SLP (superword level parallelism) is an efficient solution to exploit the parallelism, oriented to SIMD, between statements in the basic blocks, and it has been widely used in almost all the mainstream compilers. SLP relies on finding isomorphic statements to pack together into vectors. However, the capability of autovectorization for nonisomorphic statements is insufficient. In this paper, we introduce SLP-E, a novel autovectorization method that can automatically vectorize the codes which contain nonisomorphic statements, translate the nonisomorphic statements into the isomorphic statements by equivalent extended transformation of expressions, and vectorize the isomorphic statements. SLP-E improves the application scope and benefits of SLP. We implement the SLP-E in LLVM and compare it with prior approaches. A set of applications that benefit from autovectorization are taken from the SPEC CPU 2017 benchmark to compare our approach and prior techniques. Experimental results show that SLP-E achieves more than 43.9% speedup, on average, over other similar methods.