Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Seizure Observation and Documentation

&NA; This study evaluated seizure documentation after participants observed videotaped seizures to determine how their background (educational level, employment position, years of experience, practice frequency, and familiarity with epilepsy and seizures) and attributes of the seizures themselves affected their skill. Observer variables did not show significant differences when mean seizure rating scores of 348 documented seizures for 58 participants were compared. Combinations of variables were significant; certified nursing assistants (CNAs) with clinical seizure experience had significantly higher mean seizure rating scores than those without experience (p < .01). There were significant differences in the mean percentile scores for each seizure observed (p < .001). Seizures with excess motor activity had the highest scores. Most common observations for any seizure observed were location and description of movement. Participants had significantly higher scores when observing a seizure a second time (p < .001). Differences in education, employment position, and years of employment are not limiting factors in performing seizure observation and documentation for persons who have been trained and certified in the skill. Opportunities to periodically view seizures improved seizure observation and documentation. Because motor movement observations predominate seizure documents, seizure observation instruction should not only emphasize key observational details but also highlight less frequent observations, such as responsiveness, that may play a key role in seizure classification. Using videotaped seizures and a scoring tool are useful for initial training and certification as well as periodic retraining to maintain quality in the skill.
Analysis of website usability evaluation methods

The most important aspects that regulate the worth of website is Usability. There are different dimensions through which usability of websites can be evaluated. It is significant to have assured amount of methods to measure the usability of websites. The designers of websites need to know the usability level of their websites. The measurement techniques can be used to increase the usability level of website. To find out the usability level, this paper make use of two automated tools, Site Analyzer (which calculates different no of parameters such as Content, Design, Performance, SEO (Search Engines Optimization) and Page Analysis) and Qualidator tool (which checks Usability, Accessibility, SEO and Quality (technical quality)). This paper evaluates Educational Universities of Punjab and provides their ranks according to evaluation criteria.
Phoenix: Rebirth of a Cryptographic Password-Hardening Service

Password remains the most widespread means of authentication, especially on the Internet. As such, it is the Achilles heel of many modern systems. Facebook pioneered using external cryptographic services to harden password-based authentication in a large scale. Everspaugh et al. (Usenix Security ’15) provided the first comprehensive treatment of such a service and proposed the Pythia PRF-Service as a cryptographically secure solution. Recently, Schneider et al. (ACM CCS ’16) proposed a more efficient solution which is secure in a weaker security model. In this work, we show that the scheme of Schneider et al. is vulnerable to offline attacks just after a single validation query. Therefore, it defeats the purpose of using an external crypto service in the first place and it should not be used in practice. Our attacks do not contradict their security claims, but instead show that their definitions are simply too weak. We thus suggest stronger security definitions that cover these kinds of real-world attacks, and an even more efficient construction, Phoenix, to achieve them. Our comprehensive evaluation confirms the practicability of Phoenix: It can handle up to 50% more requests than the scheme of Schneider et al. and up to three times more than Pythia.
Special Bilinear Quadrilateral Elements For Locally Refined Finite Element Grids

A set of special bilinear quadrilateral elements are developed to handle irregular nodes on the interface between different refinement levels in 1-irregular meshes for the adaptive finite element method. With this alternative approach, irregular nodes are eliminated, and at the same time the C0 continuity at interelements is strictly ensured. The new elements simplify the refinement procedure and circumvent many inconveniences in local refinement with linear quadrilateral elements. Solutions to problems of a heat conduction, a reaction-diffusion, and incompressible and viscous flows past a circular cylinder are respectively presented to test the effectiveness of special elements. They demonstrate good accuracy and a potential applicability to more complex problems.
The Impact of the NCTM Standards on Pre-Service Teachers' Beliefs and Practices.

This paper describes a 2-year investigation of pre-service teachers in mathematics. Of particular interest is the degree to which the National Council of Teachers of Mathematics (NCTM) "Curriculum and Evaluation Standards for School Mathematics" (1988), the NCTM "Professional Standards for Teaching Mathematics" (1991), and other reform agendas impact preservice teacher' thinking and practice. The beliefs, perceptions, philosophies, and classroom actions of four cohorts of student teachers (n=44) were examined throughout this 2year study. Of particular interest were the pressure student teachers felt to implement the "Standards" in their teaching, their perceptions of their own teaching with respect to the "Standards," the content of their lessons, and the impact of cooperating teachers on the development of student teachers. Data were c'llected through a variety of sources (classroom observations, lesson plans, interviews, seminar sessions, survey questionnaires, and informal conversations); they were organized and analyzed from an ethnographic perspective. Analysis of the data revealed general agreement among the student teachers in their regard for the "Standards. " Although they appeared to affirm "Standards" goals and content, the student teachers almost uniformly suggested that they lack the tools to implement the "Standards" appropriately in the classroom. The consistency in the types and content of lessons observed appeared to validate this concern. An overwhelming majority of the lessons observed bore little or no resemblance to the values so highly espoused by the student teachers. Student teachers perceived pressure from the education program to include the standards in their practices, while feeling little pressure from cooperating teachers. They also pointed to cooperating teachers as the most significant influence on their teaching. (Contains 35 references.) (Author/JB) The Impact of the NCTIVI Standards on Pre-Service Teachers' Beliefs and Practices
1 Two-dimensional stick-slip on a soft elastic polymer : Pattern generation using atomic force microscopy

It has been demonstrated that it is possible to create laterally differentiated frictional patterning and threedimensional structures using the Atomic Force Microscope (AFM) probe on the surface of a soft elastic polymer, poly(dimethylsiloxane) (PDMS). The resulting effect of contact mode imaging at low loading forces (< 100 nN), observed in the lateral force mode revealed a homogeneous pattern on the PDMS surface exhibiting higher friction. With higher loading forces (>> 100 nN) the effect is non-uniform resulting in structures with depths on the nanometre scale. The topographic and frictional data revealed stick-slip responses in both the fast (orthogonal to the long axis of the lever) and slow (parallel to the long axis of the lever) directions of probe travel from scanning in a raster pattern. The stick-slip events manifest in the form of a series of shallow channels spaced evenly apart on the polymer surface. Detailed friction loop analysis acquired during the manipulation process showed that the lateral force changed according to the strength of trapping of the tip with the polymer surface exhibiting significant inplane deformation due to lateral forces being imposed. An incremented increase in the initial loading force resulted in an increase in in-plane displacement and a greater spacing between the stick lines/channels in the slow scan direction. A decrease in channel length in the fast scan direction is also observed as a result of an increase in static friction with normal force, resulting in greater surface deformation and shorter track length for sliding friction. PACS: 68.37. Ps, 81.65. Cf and 82.35. Lr 3 Author to whom correspondence should be addressed: Jolanta.Watson@Griffith.edu. au.
Online query by committee for active learning from drifting data streams

Most of data stream learning methods assume that a true class of an incoming instance is available right after it has been processed. However, assumption that we have an unlimited access to class labels is unrealistic and is directly connected with a very high labeling cost. This is a driving force behind growing development of methods that require reduced or no access to class labels. Among several potential directions active learning emerges as a promising solution, by allowing for a selection of most valuable instances from the stream and using as few label queries. Despite numerous proposals of active learning methods for static data, this domain is still developing for data streams. Here, non-stationary nature of data must be taken into consideration and proposed algorithms must accommodate potential occurrences of concept drift. In this paper we propose a Query by Committee active learning strategy that is adapted to online learning from drifting data streams. A decision regarding label query is made by an ensemble of classifiers instead of a single learner, leading to an improved instance selection. We present four different approaches for online Query by Committee and evaluate their usefulness on the basis of obtained accuracy with limited budgets and ability to handle concept drift. We introduce Budget Loss of Accuracy, a novel measure for evaluating active learning algorithms. Finally, we investigate the relationships between the efficacy of Query by Committee models and diversity of underlying ensembles. Based on thorough experimental investigation we are able to show the usefulness of proposed algorithms for reducing labeling effort in learning from drifting data streams.
Paramagnetic Levitational Assembly of Hydrogels

Tissues and organs are composed of repeating functional units. [1–3,48] Among these repeating basic cellular structures are the hexagonal lobule in liver, the nephron in kidney, and the islets in pankreas. [4–6] Tissue engineering aims to mimic the native 3D tissue architecture. [7,47] Engineered tissue constructs have broad applications in regenerative medicine[8–10] and physiological systems for pharmaceutical research. [11] In vivo, cells are surrounded by extracellular matrix (ECM), and exist in well-defined spatial organization with neighboring cells. Tissue functionality depends on these components, their interactions and relative spatial locations. [12–14] A high level of control over 3D tissue architecture has applications in identifying structure–function relationships in order to resolve underlying mechanisms and to model biological phenomena and diseases in vitro. Scaffolding and existing top-down approaches offer limited control over recapitulating 3D architecture and complex features of native tissues. [15,16] On the other hand, bottom-up methods aim to generate complex tissue structures by assembling building blocks, such as cell encapsulating microscale hydrogels. [4,17–22]
ZEGERID (omeprazole/sodium bicarbonate) Powder for Oral Suspension and Capsules safely and effectively. See full prescribing information for ZEGERID Powder for Oral Suspension and Capsules. ZEGERID (omeprazole/sodium bicarbonate) Powder for Oral Suspension and Capsules Initial U.S. Approval: 2004 --

_______________________________________________________________________________________________________________________________________ HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ZEGERID (omeprazole/sodium bicarbonate) Powder for Oral Suspension and Capsules safely and effectively. See full prescribing information for ZEGERID Powder for Oral Suspension and Capsules.
Overexpression of transforming growth factor-beta in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene

Human T-cell lymphotropic virus type I (HTLV-I) has been associated with an adult form of T-cell leukemia as well as tropical spastic paraparesis, a neurodegenerative disease. Adult T-cell leukemia patients express high levels of the type 1 isoform of transforming growth factor-beta (TGF-beta 1), which is mediated by the effects of the HTLV-I Tax transactivator protein on the TGF-beta 1 promoter. To understand further the regulation of TGF-beta 1 expression by Tax, we examined its expression in transgenic mice carrying the HTLV-I tax gene. We show that tumors from these mice and other tissues, such as submaxillary glands and skeletal muscle, which express high levels of tax mRNA selectively express high levels of TGF-beta 1 mRNA and protein. Moreover, TGF-beta 1 significantly stimulated the incorporation of tritiated thymidine into one of three cell lines derived from neurofibromas of tax-transgenic mice, which suggests that the excessive production of TGF-beta 1 may play a role in tumorigenesis and that these mice may serve as a useful model for studying the biological effects of TGF-beta in vivo.
Small Ubiquitin-like Modifier (SUMO)-mediated Repression of the Xenopus Oocyte 5 S rRNA Genes*

Background: Xenopus oocyte 5 S rRNA genes become permanently repressed after the gastrula-neurula transition. Results: TFIIIA interacts with the SUMO ligase PIAS2b and the corepressor CtBP, which occupy the oocyte but not somatic 5 S rRNA genes. Conclusion: Activation of CtBP by SUMOylation leads to repression of the oocyte genes. Significance: TFIIIA mediates repression as well as activation of 5 S rRNA transcription. The 5 S rRNA gene-specific transcription factor IIIA (TFIIIA) interacts with the small ubiquitin-like modifier (SUMO) E3 ligase PIAS2b and with one of its targets, the transcriptional corepressor, XCtBP. PIAS2b is restricted to the cytoplasm of Xenopus oocytes but relocates to the nucleus immediately after fertilization. Following the midblastula transition, PIAS2b and XCtBP are present on oocyte-type, but not somatic-type, 5 S rRNA genes up through the neurula stage, as is a limiting amount of TFIIIA. Histone H3 methylation, coincident with the binding of XCtBP, also occurs exclusively on the oocyte-type genes. Immunohistochemical staining of embryos confirms the occupancy of a subset of the oocyte-type genes by TFIIIA that become positioned at the nuclear periphery shortly after the midblastula transition. Inhibition of SUMOylation activity relieves repression of oocyte-type 5 S rRNA genes and is correlated with a decrease in methylation of H3K9 and H3K27 and disruption of subnuclear localization. These results reveal a novel function for TFIIIA as a negative regulator that recruits histone modification activity through the CtBP repressor complex exclusively to the oocyte-type 5 S rRNA genes, leading to their terminal repression.
Which Social Network or Support Factors are Associated with Cognitive Abilities in Old Age?

Background: Social networks and support have been proposed as cognitively protective in old age. As studies often consider these social factors in isolation the question of which characteristics of the social environment are beneficial remains. Objective: The current study examined associations between measures of social networks (including contact with friends/family, marital status and living arrangement), feelings of loneliness and social support, and a range of cognitive outcomes. Methods: Social network, loneliness and support data were available in the Lothian Birth Cohort 1936 (LBC1936, n = 1,091) at age 70. Participants completed a battery of cognitive tests, and factor scores were available for general cognitive ability, and the cognitive domains of processing speed and memory. Childhood cognitive ability data from age 11 were also available. Results: When examined in separate ANCOVAs, lower loneliness and more social support were significantly associated with better cognitive abilities at age 70, though not memory (independently of age, sex, childhood cognitive ability and social class), accounting for about 0.5-1.5% of the variance. When the social factors were considered simultaneously, higher loneliness remained associated with lower general cognitive ability (ηp2 = 0.005, p = 0.046), and those living alone (ηp2 = 0.007, p = 0.014) or with less social support (ηp2 = 0.007, p = 0.016) had slower processing speed. When these final models were repeated including a depression symptoms score as a covariate, the associations between loneliness and general cognitive ability, and social support and processing speed, were no longer significant. However, the association between living alone and processing speed remained (ηp2 = 0.006, p = 0.031). Conclusions: Of the social factors considered, loneliness, social support and living arrangement were most consistently associated with aspects of cognitive ability in older people, and these associations appeared to be partly, though not wholly, accounted for by symptoms of depression. Although longitudinal follow-up is required to examine the causal direction of the effects more definitively, it may be beneficial to promote the development of interventions to reduce loneliness and social isolation, and to increase social support.
The effect of animal species on in sacco degradation of dry matter and protein of feeds in the rumen

A study was undertaken on lucerne (LUC), ryegrass (RG), kikuyu (KIK), soybean meal (SBM), wheat grain (WG) and meat and bone meal (MBM) to determine the effect of animal species (sheep versus cattle) on in sacco degradation of dry matter (DM) and protein. The approach of cubic smoothing splines ®tted as a linear mixed model was used for the analysis of degradability of DM and protein of feeds. The quickly degradable DM (QDDM), cumulative slowly degradable DM (CSDDM), total degradable DM (TDDM) and rate of degradation of slowly degradable DM of LUC, RG, KIK, SBM and WG in the rumen of sheep and cattle were not different (p > 0.05). The QDDM, CSDDM and TDDM of these forages and concentrates ranged from 22.9 to 57.6, 35.3 to 54.9 and 70.2 to 92.9 (g/100 g). Estimates of in sacco quickly degradable protein (QDP), cumulative slowly degradable protein (CSDP), total degradable protein (TDP), rate of degradation of slowly degradable protein of LUC, RG, KIK and SBM were similar (p > 0.05) for sheep and cattle. For the WG a vertical shift was found in the species cubic splines ®tted to logit transformed protein degradation data. This resulted in QDP of 52.0 and 43.8 g/100 g, CSDP of 41.6 and 48.0 g/100 g and TDP of 93.6 and 91.6 g/100 g for sheep and cattle, respectively. In sacco degradation of DM and protein of MBM was irregular for both sheep and cattle, consistent with extreme heterogeneity of the concentrate. # 2000 Elsevier Science B.V. All rights reserved.
An Ontology-based Framework for Enriching Event-log Data

—Using process-aware information systems in en- terprises is becoming popular in the business environment. The systems have the capability to generate event log data that capture information about what is practically happening within enterprises. Event log data is used for process mining to extract the hidden knowledge which can assist the manager in business process management. However, the knowledge hidden in event logs would be more useful if the event logs are enriched by relevant external data sources. In this paper, we propose an approach to enrich event logs with external data sources by using ontology based data integration. We use database- to-ontology mapping techniques to integrate data sources and use semantic reasoning techniques for inferring the knowledge hidden in the data sources. A framework for the approach, illustrating examples for the implementation and expected results are presented in this paper.
Dual functions of autophagy in the response of breast tumor cells to radiation

In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also promoted autophagy in irradiated MCF-7 cells, sensitized the cells to radiation and suppressed the proliferative recovery that occurs after radiation alone. 1,25D3 enhanced radiosensitivity and promoted autophagy in MCF-7 cells that overexpress Her-2/neu as well as in p53 mutant Hs578t breast tumor cells. In contrast, 1,25D3 failed to alter radiosensitivity or promote autophagy in the BT474 breast tumor cell line with low-level expression of the vitamin D receptor. Enhancement of MCF-7 cell sensitivity to radiation by 1,25D3 was not attenuated by a genetic block to autophagy due largely to the promotion of apoptosis via the collateral suppression of protective autophagy. However, MCF-7 cells were protected from the combination of 1,25D3 with radiation using a concentration of chloroquine that produced minimal sensitization to radiation alone. The current studies are consistent with the premise that while autophagy mediates a cytoprotective function in irradiated breast tumor cells, promotion of autophagy can also confer radiosensitivity by vitamin D (1,25D3). As both cytoprotective and cytotoxic autophagy can apparently be expressed in the same experimental system in response to radiation, this type of model could be utilized to distinguish biochemical, molecular and/or functional differences in these dual functions of autophagy.
Prediction of maximal oxygen uptake in sedentary males from a perceptually regulated, sub-maximal graded exercise test

Abstract The purpose of this study was to assess the validity of predicting the maximal oxygen uptake ([Vdot]O2max) of sedentary men from sub-maximal [Vdot]O2 values obtained during a perceptually regulated exercise test. Thirteen healthy, sedentary males aged 29 – 52 years completed five graded exercise tests on a cycle ergometer. The first and fifth test involved a graded exercise test to determine [Vdot]O2max. The two maximal graded exercise tests were separated by three sub-maximal graded exercise tests, perceptually regulated at 3-min RPE intensities of 9, 11, 13, 15, and 17 on the Borg ratings of perceived exertion (RPE) scale, in that order. After confirmation that individual linear regression models provided the most appropriate fit to the data, the regression lines for the perceptual ranges 9 – 17, 9 – 15, and 11 – 17 were extrapolated to RPE 20 to predict [Vdot]O2max. There were no significant differences between [Vdot]O2max values from the graded exercise tests (mean 43.9 ml · kg−1 · min−1, s = 6.3) and predicted [Vdot]O2max values for the perceptual ranges 9 – 17 (40.7 ml · kg−1 · min−1, s = 2.2) and RPE 11 – 17 (42.5 ml · kg−1 · min−1, s = 2.3) across the three trials. The predicted [Vdot]O2max from the perceptual range 9 – 15 was significantly lower (P < 0.05) (37.7 ml · kg−1 · min−1, s = 2.3). The intra-class correlation coefficients between actual and predicted [Vdot]O2max for RPE 9 – 17 and RPE 11 – 17 across trials ranged from 0.80 to 0.87. Limits of agreement analysis on actual and predicted [Vdot]O2 values (bias ± 1.96 × s diff) were 3.4 ml · kg−1 · min−1 (±10.7), 2.4 ml · kg−1 · min−1 (±9.9), and 3.7 ml · kg−1 · min−1 (±12.8) (trials 1, 2, and 3, respectively) of RPE range 9 – 17. Results suggest that a sub-maximal, perceptually guided graded exercise test provides acceptable estimates of [Vdot]O2max in young to middle-aged sedentary males.