Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantum password authentication against man-inthe-middle attack

Authentication with recently proposed quantum password protocol is secure against impersonation. Here we show that original version of the protocol is not secure against active malicious prover and verifier, however a slight modification provides a possibility for a legitimate party to detect the attacks. The password is reusable in the absence of the attacks. Otherwise the security of the authentication scheme should be provided by password change. In this way the overall scheme becomes resistant to man-in-the-middle attack.
Positional correlation in laser-excited three-body Coulomb systems.

Using a novel six-laser excitation scheme we have created heliumlike planetary states (nlNd) in barium with n\ensuremath{\ge}30, N\ensuremath{\ge}60, and l\ensuremath{\ge}4, which are equivalent of a true three-body Coulomb system. Extremely strong positional correlation effects were observed and quantitatively explained by the repulsion between a ``frozen'' outer electron and the highly polarizable inner electron. The model was experimentally verified by removing the outer electron and recording the inner electron excitation in the presence of an equivalent electric field.
Norwalk virus infection associates with secretor status genotyped from sera

ABO histo‐blood group type and secretor status are two genetically determined factors that contribute to resistance and susceptibility to Norwalk virus (NV). Archived serum samples but not saliva samples are available from NV and many other norovirus challenge studies and outbreaks. A person's ABO phenotype is easily determined from their archived sera, but the individual's secretor phenotype cannot easily be ascertained without saliva. We now report that a person's secretor genotype can also be determined from the archived serum samples. Of the 51 volunteers who participated in a NV challenge study, all eight non‐secretors were resistant to NV infection, all of the 42 NV‐infected volunteers were secretor positive, and a single uninfected secretor was histo‐blood group type B. In agreement with a previous report, secretor status was most predictive of risk of NV infection. The methods described in this report should rapidly improve our knowledge of the associations between carbohydrate antigen expression and susceptibility to different strains of the non‐cultivatable noroviruses by enabling retrospective studies from previously collected volunteer challenge and outbreak sera. J. Med. Virol. 77:116–120, 2005. © 2005 Wiley‐Liss, Inc.
A Diversity-Enhanced Resource Allocation Strategy for Decomposition-Based Multiobjective Evolutionary Algorithm

The multiobjective evolutionary algorithm (MOEA) based on decomposition transforms a multiobjective optimization problem into a set of aggregated subproblems and then optimizes them collaboratively. Since these subproblems usually have different degrees of difficulty, resource allocation (RA) strategies have been reported to enhance performance, attempting to dynamically assign proper amounts of computational resources for the solution of each of these subproblems. However, existing schemes for decomposition-based MOEAs fully rely on the relative improvement of the aggregated functions to do this. This paper proposes a diversity-enhanced RA strategy for this kind of MOEA, depending on both relative improvement on aggregated function value and solution density around each subproblem to assign computational resources. Thus, one subproblem surrounded with fewer solutions in its neighboring area and more relative improvement on the aggregated function value will be allocated a higher probability for evolution. Our experimental results show the advantages of our proposed strategy over two popular RA strategies available for decomposition-based MOEAs, on tackling a set of complicated benchmark problems.
A novel small signal modeling of series resonant converter based on peak value of resonant current

This paper presents a novel small signal analysis model based on peak value of resonant current to design controller of SRC. The small signal analysis of voltage controller is divided into software controller and SRC circuit. The software controller consists a PI controller and a voltage-to-frequency gain. The small signal model of SRC circuit is derived based on the assumptions where the output capacitor is small and the energy is transferred to load using controlled current source. The peak value of resonant current will be changed in proportional to the perturbation of small signal frequency command under constant load. Thereby the frequency to resonant current transfer function can be derived. Then the gains of PI voltage controller are yielded by Bode plot according to the required specifications under nominal condition. Moreover, simulated results by Simulink are carried out to analysis the controller design. In order to verify the correctness of proposed design method, a DSP-based SRC is constructed and tested by frequency response analyzer, which shows that the design and measured results are in good agreement and the bandwidth of voltage loop is near to 2 kHz.
CONCENTRATIONS OF CSF PROTEINS AS A MEASURE OF BLOOD BRAIN BARRIER FUNCTION AND SYNTHESIS OF IgG WITHIN THE CNS IN ‘NORMAL’ SUBJECTS FROM THE AGE OF 6 MONTHS TO 30 YEARS

ABSTRACT. Eeg‐Olofsson, O. , Link, H. and Wigertz, A. (Departments of Neurology and Pediatrics, University Hospital, Linköping, Sweden). Concentrations of CSF proteins as a measure of blood brain barrier function and synthesis of IgG within the CNS in ‘normal’ subjects from the age of 6 months to 30 years. Acta Paediatr Scand, 70:167, 1981. –Concentrations of proteins in cerebrospinal fluid (CSF) and serum have been studied in 105 ‘normal’ subjects divided into age groups 0.5–5, 6–15, 16–20, and 21–30 years in order to obtain reference values for information concerning blood brain barrier damage and synthesis of immunoglobulins within the central nervous system (CNS). CSF/serum albumin ratio is superior to CSF total protein as a test of the blood brain barrier function. The IgG synthesis rate per 24 hours and IgG index [CSF/serum IgG ratio]: [CSF/serum albumin ratio] reflect the presence of IgG synthesis within the CNS. The variables reflecting the blood brain barrier function increased with age, the upper values of the CSF/serum albumin ratio being 4.0, 4.9, 6.7, and 6.5 for the mentioned age groups respectively. The upper values for the CSF IgG index reamined rather constant in relation to age at 0.62,0.68,0.64, and 0.63 respectively. An index value of less than 0.70 and an IgG synthesis of less than 10 mg/24 hours seem to be appropriate upper values as refereneces. Only about 1–2 ml of CSF and 0.5 ml serum are required for the analyses including cell counting and determinations of IgA and IgM index values as well as of glucose and lactate.
Roles for miRNAs in endocrine resistance in breast cancer.

Therapies targeting estrogen receptor alpha (ERα), including selective ER modulators such as tamoxifen, selective ER downregulators such as fulvestrant (ICI 182 780), and aromatase inhibitors such as letrozole, are successfully used in treating breast cancer patients whose initial tumor expresses ERα. Unfortunately, the effectiveness of endocrine therapies is limited by acquired resistance. The role of microRNAs (miRNAs) in the progression of endocrine-resistant breast cancer is of keen interest in developing biomarkers and therapies to counter metastatic disease. This review focuses on miRNAs implicated as disruptors of antiestrogen therapies, their bona fide gene targets and associated pathways promoting endocrine resistance.
CEACAM6 Is a Novel Biomarker in Pancreatic Adenocarcinoma and PanIN Lesions

Objective:The purpose of this study was to test the hypothesis that CEACAM6 expression is an indicator of adverse pathologic features and clinical outcome in pancreatic adenocarcinoma. Summary Background Data:Previously, we have demonstrated carcinoembryonic antigen–related cell adhesion molecule 6 (CEACAM6) to be an oncoprotein that plays an important role in the biology of pancreatic adenocarcinoma. Suppression of CEACAM6 expression reduces tumorigenesis and metastasis in vivo. Methods:A tissue microarray was constructed using tumor specimens obtained from 89 consecutive patients who had undergone pancreatic resection for pancreatic adenocarcinoma with curative intent. A second microarray containing 54 pancreatic intraepithelial neoplasia (PanIN) lesions was constructed using tissues from a separate cohort of 44 patients. Both arrays were immunostained using a specific anti-CEACAM6 monoclonal antibody. Tumoral CEACAM6 expression was dichotomized into negative and positive immunoreactivity groups. The log-rank test was used to evaluate univariate associations of CEACAM6 expression with prognosis. Survival curves were derived using the Kaplan-Meier method. Results:Tumoral CEACAM6 expression was detected in 82 (92%) pancreatic adenocarcinoma specimens. CEACAM6 expression was more prevalent in high-grade than in low-grade PanIN lesions (P = 0.0002). Negative tumoral CEACAM6 expression was associated with absence of lymph node metastases (P = 0.012), lower disease stage (P = 0.008), and longer postoperative survival (P = 0.047). Conclusions:CEACAM6 is a novel biomarker for pancreatic adenocarcinoma. CEACAM6 warrants further evaluation as both a prognostic factor and a therapeutic target in pancreatic cancer.
Algorithms for Masking Pixel Defects at Low Exposure Conditions for CMOS Image Sensors

This paper introduces certain innovative algorithms to mask for pixel defects seen in image sensors. Pixel defectivity rates scale with pixel architecture and process nodes. Smaller pixel and process nodes introduce more defects in manufacturing. Brief introduction to causes for pixel defectivity at lower pixel nodes is explained. Later in the paper, popular defect correction schemes used in image processing applications are discussed. A new approach for defect correction is presented and evaluated using images captured from an 8M Bayer image sensor. Experimentation for threshold evaluation is done and presented with practical results for better optimization of proposed algorithms. Experimental data shows that proposed defect corrections preserves a lot of edge details and corrects for bright and hot pixels/clusters, which are evaluated using histogram analysis.
MEMS force microactuator with displacement sensing for mechanobiology experiments

This paper presents a Micro Electro-Mechanical System (MEMS) that performs electrostatic force actuation and capacitive microdisplacement sensing in the same chip. By driving the actuator with a given voltage, a known force can be applied to a microsample under test by using a silicon probe tip, while the obtained displacement is measured. This allows to extract the mechanical properties of the microsample entirely on chip, and to derive its force-displacement curve without external equipment. The proposed device is intended for mechanobiology experiments, where the microsample is made of biological tissues or cells. The device generates a force in the order of few micronewtons and a maximum displacement of 1.8 μm can be measured.
Monitoring of human papillomavirus vaccination

Persistent infection with oncogenic human papillomavirus (HPV) is a necessary causal factor in the development of cervical cancer. Moreover, HPV, predominately type 16 and to a lesser degree type 18, is linked causally to varying proportions of other anogenital cancers (vulva, vagina, penis, anus) as well as cancers elsewhere in the body (oropharynx, larynx, conjunctiva). HPV types 6 and 11 cause most of genital warts and recurrent respiratory papillomatosis. Effective prophylactic vaccines have been developed. In this review, we address briefly the immunological aspects of HPV infection and the results of HPV vaccination trials. Internationally standardized monitoring and evaluation of prophylactic HPV vaccination programmes will be essential for arriving at the most cost‐effective strategies for cancer control.
FLEXIBLE SCORE FOLLOWING: THE PIANO MUSIC COMPANION AND BEYOND

In our talk we will present a piano music companion that is able to follow and understand (at least to some extent) a live piano performance. Within a few seconds the system is able to identify the piece that is being played, and the position within the piece. It then tracks the performance over time via a robust score following algorithm. Furthermore, the system continuously re-evaluates its current position hypotheses within a database of scores and is capable of detecting arbitrary ‘jumps’ by the performer. The system can be of use in multiple ways, e.g. for piano rehearsal, for live visualisation of music, and for automatic page turning. At the conference, we will demonstrate this system live on stage. If possible, we would also like to encourage (hobby-)pianists in the audience to try the companion themselves. Additionally, we will give an outlook on our efforts to extend this approach to classical music in general, including heavily polyphonic orchestral music.
COMPARISON OF HYPERTONIC WITH ISOTONIC SALINE HYDROXYETHYL STARCH SOLUTION ON OXYGEN EXTRACTION CAPABILITIES DURING ENDOTOXIC SHOCK

Hypertonic colloid solutions reportedly exert protective effects on the microcirculation. The present study investigated the effects of a hypertonic saline hydroxyethyl starch (HES) solution on the oxygen extraction capabilities in an endotoxic shock model in the dog. Fourteen anesthetized and mechanically ventilated dogs received 2 mg/kg of Escherichia coli endotoxin before being randomly divided into two groups to receive a 4 mL/kg infusion in 10 min of either hypertonic (7.5%, n = 7), or isotonic (.9%, n = 7) HES solution. Thereafter, each animal received isotonic HES titrated to restore cardiac index to baseline levels, followed by a constant infusion of normal saline at 20 mL/kg throughout the study. The amount of fluid required to restore cardiac index to baseline levels was approximately one-half in the hypertonic saline HES group as compared with the isotonic group (123 ± 12 vs. 291 ± 62 mL/kg, p < .05). The two groups of dogs had similar mean arterial pressure and cardiac index values. Hypertonic saline HES-treated animals had a higher sodium concentration than the control group (144.4 ± 4.0 vs. 138.7 ± 3.1 mM/L, p < .05). There were no significant differences in blood gases or lactate concentrations between the groups. When cardiac tamponade was induced to study the tissue oxygen extraction capabilities, hypertonic saline HES-treated dogs had a slightly lower critical oxygen delivery (11.1 ± 1.6 vs. 14.2 ± 3.3 mL/kg·min, p = NS), and a significantly higher critical oxygen extraction ratio (61.9 ± 17.1 vs. 44.0 ± 11.5%, p < .05) than the isotonic group. We conclude that during endotoxic shock in dogs, hypertonic saline HES solution can increase whole body oxygen extraction capabilities, probably by an improvement in microvascular perfusion in septic conditions.
A 3O Sulfated Heparan Sulfate Binding Peptide Preferentially 3 Targets Herpes Simplex Virus Type-2 Infected Cells . 4 5 Running Title : HS Binding Peptide Targets HSV-2 Infected Cells 6 7

REVISED: JVI00433-12 1 2 A 3-O Sulfated Heparan Sulfate Binding Peptide Preferentially 3 Targets Herpes Simplex Virus Type-2 Infected Cells. 4 5 Running Title: HS Binding Peptide Targets HSV-2 Infected Cells 6 7 Mohamed M. Ali, Ghadah A Karasneh, Min Jung Jarding , Vaibhav Tiwari , 8 and Deepak Shukla 9 Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois 10 at Chicago, 1855 W. Taylor, Chicago, IL 60612, USA. 11 Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at 12 Chicago, 1919 W. Taylor, Chicago, IL 60612, USA. 13 Department of Microbiology and Immunology, College of Medicine, University of Illinois at 14 Chicago, 835 S. Wolcott, Chicago, IL 60612, USA 15 Department of Microbiology/Immunology, Midwestern University, 555 31st street, Downers 16 Grove, IL 60515, USA 17
Local color transfer between images using dominant colors

Abstract. A color-transfer method that can transfer colors of an image to another for the local regions using their dominant colors is proposed. In order to naturally transfer the colors and moods of a target image to a source image, we need to find the local regions of colors that need to be modified in the image. Since the dominant colors of each image can be used for the estimation of color regions, we develop a grid-based mode detection, which can efficiently estimate dominant colors of an image. Based on these dominant colors, our proposed method performs a consistent segmentation of source and target images by using the cost-volume filtering. Through the segmentation procedure, we can estimate complex color characteristics and transfer colors to the local regions of an image. For an intuitive and natural color transfer, region matching is also crucial. Therefore, we use the visually prominent colors in the image to meaningfully connect each segmented region in which modified color-transfer method is applied to balance the overall luminance of the final result. In the Experimental Result section, various convincing results are demonstrated through the proposed method.
Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci

Group A streptococcal (Streptococcus pyogenes) diseases remain a major public health problem in developing countries as well as in the indigenous populations of developed countries. In view of the large number of Group A streptococcal infections and the potential for sequelae such as rheumatic heart disease, control strategies including the development of an anti-streptococcal vaccine that is able to prevent infection and colonization is important. In this article, we discuss the epidemiology and strain variability of Group A streptococcus and how this is rendering vaccine development more challenging. We discuss vaccine strategies with a focus on the conserved region of the M protein and present a viewpoint for the impediments and the way forward.
Biphasic Electrospray Ionization for the Study of Interfacial Complexes

Biphasic electrospray ionization (BESI) mass spectrometry is achieved by using a dual-channel microsprayer, where channels filled with different immiscible phases meet at the Taylor cone. Two types of interfacial complexation reactions have been studied: the interfacial complexation of aqueous lead ions by thioether crown molecules, and the interfacial complexation of an aqueous dipeptide by dibenzo-18-crown-6 as ionophore. The mass spectra also give valuable information on the stoichiometry of the complexation reaction.
Vehicle Routing with Stochastic Demands: Properties and Solution Frameworks

This paper considers the vehicle routing problem with stochastic demands. The objective is to provide an overview of this problem, and to examine a variety of solution methodologies. The concepts and the main issues are reviewed along with some properties of optimal solutions. The existing stochastic mathematical programming formulations are presented and compared and a new formulation is proposed. A new solution framework for the problem using Markovian decision processes is then presented.
NORF5/HUG1 Is a Component of theMEC1-Mediated Checkpoint Response to DNA Damage and Replication Arrest in Saccharomyces cerevisiae

ABSTRACT Analysis of global gene expression in Saccharomyces cerevisiae by the serial analysis of gene expression technique has permitted the identification of at least 302 previously unidentified transcripts from nonannotated open reading frames (NORFs). Transcription of one of these, NORF5/HUG1 (hydroxyurea and UV and gamma radiation induced), is induced by DNA damage, and this induction requires MEC1, a homolog of the ataxia telangiectasia mutated (ATM) gene. DNA damage-specific induction of HUG1, which is independent of the cell cycle stage, is due to the alleviation of repression by the Crt1p-Ssn6p-Tup1p complex. Overexpression of HUG1 is lethal in combination with a mec1 mutation in the presence of DNA damage or replication arrest, whereas a deletion of HUG1 rescues the lethality due to a mec1 null allele. HUG1 is the first example of a NORF with important biological functional properties and defines a novel component of the MEC1checkpoint pathway.
Drug Resistance of HIV‐1 Protease Against JE‐2147: I47V Mutation Investigated by Molecular Dynamics Simulation

Anti‐retroviral therapies for acquired immunodeficiency syndrome (AIDS) patients are at risk because of drug resistance that has been identified with a number of currently marketed drugs. HIV‐1 protease (HIV‐pr), a well‐validated AIDS therapeutic target, undergoes various mutations leading to resistance such existing drugs. However, the molecular basis of drug resistance of HIV‐pr is still not fully understood. JE‐2147, an experimental inhibitor of HIV‐pr, shows a resistance profile different from that of known drugs. Noteworthy, it is less susceptible to several common mutations, but it is still susceptible to a few mutations, including I47V which appears to be specific for JE‐2147. In this work, the molecular details of the effect of I47V mutation is investigated using molecular dynamics simulation. Four simulations of apo and complexed proteins in their wild type (WT) and mutant forms have been performed. It is found that the mobility of the side chain of mutant Val47 in chain B of HIV‐pr about the inhibitor increases significantly relative to WT Ile47 in chain B. This is due to loss of optimized packing of the inhibitor to the residue 47 in chain B of the mutant when compared with WT enzyme. There also are subtle differences in motion involving residues in the flap region, which are more prominent in the apo form.
Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells

Conclusions. The results suggest that the anti-inflammatory effect of caffeic acid phenethyl ester (CAPE) is due to its inhibition of tumor necrosis factor (TNF)-α expression and interleukin (IL)-8 production. The anti-inflammatory effect of CAPE is possibly through the inhibition of nuclear factor (NF)-κB via the suppression of inhibitor-κB-α (IκB-α) degradation. Objectives. CAPE is a biologically active component of propolis, a resinous material obtained from bee hives, which originates from conifer bark. The effect of CAPE on lipopolysaccharide (LPS)-induced inflammatory reactions is not known. The aim of this study was to evaluate the anti-inflammatory effect of CAPE on cultured human middle ear epithelial cells (HMEECs). Materials and methods. The effect of CAPE on LPS-induced TNF-α expression was evaluated in HMEECs by real-time reverse transcription polymerase chain reaction (RT-PCR). LPS-induced IL-8 production was determined by enzyme-linked immunosorbent assay (ELISA), and LPS-induced IκB-α degradation was followed by Western blot analysis. Results. CAPE significantly inhibited LPS-induced up-regulation of TNF-α in a dose-dependent manner. IL-8 production by LPS was significantly suppressed by the CAPE pretreatment. Furthermore, LPS-induced IκB-α degradation was suppressed by the CAPE pretreatment.
Bonner Verlaufsbogen: Dokumentation der relevanten Parameter während der intravitrealen Medikamentenapplikation

For an efficient documentation during Anti-VEGF-therapy we designed a novel record form, to summarize all relevant parameters such as visual acuity, optical coherence tomography (OCT), fluorescence angiography (FAG) as well as edema, haemorrhages or RPE-tears on biomicroscopy.