Miracle-dz/UniFAR-FTUs huggingface dataset:
IVS8 polyT and M470V polymorphisms in healthy individuals and cystic fibrosis patients in Mazandaran province, Iran

Background : Cystic fibrosis (CF) is a multiorgan autosomal recessive disorder. As CF is highly heterogeneous in Iran and many mutations have a low frequency, routine molecular diagnostic methods are not very efficient. The use of highly polymorphic intragenic markers not only can facilitate phenotype prediction in prenatal diagnosis by gene tracking, but also can lead to the demonstration of possible associations between haplotypes and specific mutations. We determined IVS8 polyT and M470V polymorphisms in exon 10 of CFTR gene in this case-control study. Methods : Polymorphisms of IVS8 polyT in 53 patients with CF were referred to Amirkola children's Hospital of Babol University of Medical Sciences, 2007 to 2011 and 49 fertile healthy individuals were determined by reverse dot blot method. M470V polymorphism was analyzed by PCR-RFLP. Results : In IVS8 polyT study, T7 was the most frequent allele in healthy individuals than patients with CF (respectively, 82.8% Vs. 77.2%). T9 was more abundant in patients with CF than normal individuals (respectively, 21.7% Vs. 7.4%, P=0.005). T9/T9 genotype was more frequent in patients than healthy individuals (respectively, 15.1% and 2%, P=0.032). Study for M470V polymorphism showed that M/V was the most common genotype in normal individuals and patients with CF (respectively, 49% and 40.4%). M-T9 haplotype was highly associated with the disease in both patients with CF and normal individuals (respectively, 19.1% and 2.4%, (P Conclusion : The allelic distribution and heterozygosity results suggest that both M470V and IVS8 polyT can be helpful in the prenatal diagnosis of CF in Northern Iranians with a positive family history of the disease.
Phytoplankton distribution and their relationship to environmental variables in Sanya Bay, South China Sea

Phytoplankton quantification was conducted in Sanya Bay from January 2005 to February 2006. A submersible in situ spectrofluorometer, which permits the differentiation of four algal groups (green algae, diatoms and dinoflagellates, cryptophytes and cyanobacteria) was used. Seasonal variation of total chlorophyll a concentration showed that high value appeared in summer and low concentration occurred in spring. Diatoms and dinoflagellates group was the predominant phytoplankton all year in the Bay. The stable stratification of phytoplankton vertical distribution came into being in July. During the stratification event, the total chlorophyll a concentration of deep layer was much higher than the surface; cyanobacteria and cryptophyta groups decreased and almost disappeared, however, the concentration of green algae and diatoms and dinoflagellates groups increased. In deep layer, the concentration of diatoms and dinoflagellates group increased sharply, which was about eight times more than that in the surface layer. The vertical profiles character of phytoplankton showed that from inshore stations to outer bay the stratification of phytoplankton vertical distribution gradually strengthened. Dissolved inorganic nutrient especially phosphate and inorganic nitrogen and cold-water upwelling were the main regulating factor for phytoplankton distribution.
A Cost Effective Engine Health Monitoring System for On-Board Use on Hovercraft

Hovercraft operate in a very hostile environment, subject to continuous spray conditions. In salt water or dusty environments, this can lead to rapid engine performance deterioration. The need for a cost effective Engine Health Monitoring (EHM) system operable by the crew, preferably on-board, clearly existed. Such a system was developed for the Bell Aerospace Canada Voyageur hovercraft making use of only existing engine instrumentation in conjunction with a programmable calculator. This approach was readily accepted by both craft operators and maintenance personnel.
Relationship between life style-related factors with cardiac ischemia among inpatients: A case-control study

Introduction : More than seventeen millions people die due to cardiovascular diseases which account for one third of death worldwide. Half of 60% of all mortality caused by acquired diseases throughout the world is due to heart disorders and this ratio will augment to 73% by 2020. It is known that individual lifestyle has a great influence on the well-being of cardiovascular system. Seven of the top ten etiologies leading to death are related to the pattern of lifestyle. This study explored various lifestyle-related factors affecting ischemic conditions. Method : This study was performed as a case control investigation on 65 subjects along with 65 controls who were all admitted at Sevome Shaaban hospital in Damavand town of Iran. All data ) demographic and life-style variables) were gathered, using three different types of questionnaire obtained from each person. p< 0.05 was considered as significant. Results : Age, marriage status, smoking, physical activities, diet and mental health condition were shown to have a significant effect on ischemia (P <0.001). Insufficient physical activities, fatty and low fiber food as well as impaired psychology conditions were among the risk factors that contributed to Ischemic heart disease. Conclusion : Insufficient physical activities, fatty and low fiber food as well as impaired psychology conditions were among the risk factors that contribute to ischemic heart disease. Keywords: Ischemia, Life style, Physical activity, Psychologist
Knowledge-intensive Business Services: Processing Knowledge and Producing Innovation

Knowledge-intensive business services (KIBS) can be defined as activities in which knowledge is both the input and the main output. The aim of this paper is twofold. Firstly, it seeks to describe a normal service transaction in terms of the various basic modes of knowledge processing and production used by KIBS firms. Secondly, it seeks to establish the links and boundaries between a normal transaction of this kind and innovation, whether produced within or through the use of KIBS.
A Critical Review of Barriers to Export Business

Exporting is a common mode to enter international business. However, there are many organisations which face difficulties in their international venture. Therefore, it is critical to understand the export barriers that may affect organizations. The article tries to identify the issues that are related to export barriers. The review found that past researchers have found conflicting findings in terms of export barriers. However, there are some common grounds too.
Comparative Analysis of Semiconductor Power Losses of Galvanically Isolated Quasi-Z-Source and Full-Bridge Boost DC-DC Converters

Abstract This paper compares semiconductor losses of the galvanically isolated quasi-Z-source converter and full-bridge boost DC-DC converter with active clamping circuit. Operation principle of both converters is described. Short design guidelines are provided as well. Results of steady state analysis are used to calculate semiconductor power losses for both converters. Analytical expressions are derived for all types of semiconductor power losses present in these converters. The theoretical results were verified by means of numerical simulation performed in the PSIM simulation software. Its add-on module “Thermal module” was used to estimate semiconductor power losses using the datasheet parameters of the selected semiconductor devices. Results of calculations and simulation study were obtained for four operating points with different input voltage and constant input current to compare performance of the converters in renewable applications, like photovoltaic, where input voltage and power can vary significantly. Power loss breakdown is detailed and its dependence on the converter output power is analyzed. Recommendations are given for the use of the converter topologies in applications with low input voltage and relatively high input current.
Duality and Fibrations on G_2 Manifolds

We argue that G_2 manifolds for M-theory admitting string theory Calabi-Yau duals are fibered by coassociative submanifolds. Dual theories are constructed using the moduli space of M-five-brane fibers as target space. Mirror symmetry and various string and M-theory dualities involving G_2 manifolds may be incorporated into this framework. To give some examples, we construct two non-compact manifolds with G_2 structures: one with a K3 fibration, and one with a torus fibration and a metric of G_2 holonomy. Kaluza-Klein reduction of the latter solution gives abelian BPS monopoles in 3 + 1 dimensions.
An Inverse-Linear Logistic Model of The Main Sequence

A model of the main sequence is proposed based on the logistic function. The model’s fit to the peak velocity-amplitude relation resembles an S curve, simultaneously allowing control of the curve’s asymptotes at very small and very large amplitudes, as well as its slope over the mid-amplitude range. The proposed inverse-linear logistic model is also able to express the linear relation of duration and amplitude. We demonstrate the utility and robustness of the model when fit to aggregate data at the smalland mid-amplitude ranges, namely when fitting microsaccades, saccades, and superposition of both. We are confident the model will suitably extend to the largeamplitude range of eye movements.
Concurrent formation of supermassive stars and globular clusters: implications for early self-enrichment

We present a model for the concurrent formation of globular clusters (GCs) and supermassive stars (SMSs, ≳103 M⊙) to address the origin of the HeCNONaMgAl abundance anomalies in GCs. GCs form in converging gas flows and accumulate low-angular momentum gas, which accretes on to protostars. This leads to an adiabatic contraction of the cluster and an increase of the stellar collision rate. A SMS can form via runaway collisions if the cluster reaches sufficiently high density before two-body relaxation halts the contraction. This condition is met if the number of stars ≳106 and the gas accretion rate ≳105 M⊙ Myr−1, reminiscent of GC formation in high gas-density environments, such as – but not restricted to – the early Universe. The strong SMS wind mixes with the inflowing pristine gas, such that the protostars accrete diluted hot-hydrogen burning yields of the SMS. Because of continuous rejuvenation, the amount of processed material liberated by the SMS can be an order of magnitude higher than its maximum mass. This ‘conveyor-belt’ production of hot-hydrogen burning products provides a solution to the mass budget problem that plagues other scenarios. Additionally, the liberated material is mildly enriched in helium and relatively rich in other hot-hydrogen burning products, in agreement with abundances of GCs today. Finally, we find a super-linear scaling between the amount of processed material and cluster mass, providing an explanation for the observed increase of the fraction of processed material with GC mass. We discuss open questions of this new GC enrichment scenario and propose observational tests.
Can You Relate? The Importance of Need Satisfaction for the Quality and Progressive Union Formation Process of Intimate Relationships

Dieser Beitrag befasst sich mit der Bedeutung von Autonomie und Verbundenheit als zentrale Bedurfnisse in Paarbeziehungen und untersucht Einflusse der Bedurfniserfullung auf die Partnerschaftsqualitat und fortschreitende Institutionalisierung von Paarbeziehungen. Anhand einer Stichprobe von 1914 Paaren und einem langsschnittlichen, dyadischen Design werden Akteur- und Partnereffekte partnerschaftlicher Autonomie und Verbundenheit auf die Partnerschaftsqualitat und den partnerschaftlichen Institutionalisierungsprozess ermittelt. Eine Clusteranalyse erbrachte vier Typen der partnerschaftlichen Bedurfniserfullung, die sich durch hohe Werte in beiden Bereichen, hohe Werte in jeweils nur einem Bereich oder geringe Bedurfniserfullung in beiden Bereichen auszeichnen. Eine balancierte Erfullung von Autonomie und Verbundenheit sagt die vergleichsweise hochsten Werte an Partnerschaftszufriedenheit und Zukunftsorientierung vorher. Daruber hinaus reduziert eine geringe Bedurfniserfullung in Partnerschaften das Fortschreiten des partnerschaftlichen Institutionalisierungsprozesses (Zusammenziehen, Heirat, Geburt eines Kindes). Fur Frauen sind starkere Akteur- und Partnereffekte der partnerschaftlichen Bedurfniserfullung nachzuweisen als fur Manner.
Creating value in accounting education with a qualitative research methodology

This article reports on the transformative design principles that were generated during the process of better aligning accounting education with accounting practice. Managing the risk of a disparity between accounting education and practice by matching the dynamics of the workplace and education arena could create value for the accounting graduate and the employer. In the process of change necessary for the integration of accounting software skills in accounting education transformation design principles were identified as imperative ground rules. The development and conceptualisation of the transformation design principles were drawn from iterative cycles, unique coding and analysis from the infusion of two research methods. The infusion of the two research methods contributed to the development of the transformative design principles, which led to the reform of accounting education in higher education. The transformative design principles developed are demonstrated to have generic properties that could be applied to other environments.
The super-resolution of linear structures in image data

Super-resolution of images, particularly the separation of point sources within the Rayleigh limit of an optical system, has been empirically and theoretically proved. Issues remain, however, around the ability to perform true super-resolution of structure within extended objects. Puschmann and Kneer [1] conclude that “super-resolution cannot be achieved for extended objects which are not band limited. ” They do find that sharpening by contrast enhancement was possible in extended images. Examination of the theoretical work of Donoho [2] suggests the possibility of resolving linear structures under certain conditions. The resolution enhancement is only possible in the direction normal to the feature’s length vector. I discuss here the required conditions for super-resolution of these objects and propose a modification of the Magain, Courbin and Sohy (MCS) method [3] that allows super-resolved reconstruction of linear features.
Mandatory Recognition of Externalities, Price Elasticity and the Market Value of Firms

The scene for environmental performance and disclosures is changing rapidly from that of a voluntary state to one where both are being mandated. One such regulatory initiative is that of the European Union Emissions Trading Scheme (EU ETS), under which all firms within certain industries have to comply with similar environmental performance and disclosure requirements. The imposition of such requirements can have both adverse and beneficial effects on firm value. The purpose of this study is to examine how EU ETS membership affects the market value of European firms. Using a sample of 1,985 firm-year observations from Great Britain, France, Germany, Spain and Italy, I find that joining the EU ETS has a positive impact on firm value, and this impact is larger for firms with high price elasticity of demand (PED). These findings suggest that a regulated environmental performance and environmental disclosure setting is likely to reduce uncertainties pertaining to externalities, in particular, for firms which are unable to shift their externality costs to their consumers.
Implications of social supports for adolescents' education and career aspirations.

Two hundred and sixty grade 9 through 12 students completed questionnaires designed to examine relations among social support, perception of future opportunity, and education and career aspirations and expectations. Path analyses showed that for both males and females, perception of opportunity predicts educational expectations, which, in turn, predict educational aspirations and career expectations. For females, peer, family and teacher supports predict perception of opportunity, whereas for males only family support is predictive of perception of opportunity. ANOVAs demonstrated that females perceive more teacher and peer support than do males, and that compared to their male peers, females have greater perceived future opportunity, educational aspirations and expectations, and career expectations. Both males and females indicate a greater gap between career aspirations and expectations than between education aspirations and expectations. The possible contributions of socioeconomic conditions and gendered socialization are discussed. Resume
Flows of movement: singularities, intensities and attractors as event generators

The aim of this research is to conceptualise on the built form under the spectrum of extreme conditions using notions of movement, organization of flows, agent based theories and event occurrence and generation. Extreme conditions are defined as ‘events’ taking place within spatial configurations of form that create intense density and movement fluctuation, social interaction that affects decision making and peoples’ aggregation. An event is a temporal phenomenon, a singularity that occurs in time, an ‘emergent phenomena’ that causes disturbances and irregularities. [5] The built environment is understood as a complex adaptive system (CAS) and is governed by all their properties. As all CAS, spatial systems are best understood when under ‘critical conditions’ reach their limits. In every organism there needs to be a ‘critical point’ in order for the system to become unstable, bifurcate and evolve into a new state of equilibrium. Movement, whether on open urban spaces such as squares and pedestrian ways, or in a micro-scale of a building, such as a museum, shopping mall, or transport station plays a key role in the way the space is occupied and determine the way it should be designed. The goal is to visualise a system that self-organises in form and activity according to the generation of events. More events are introduced and act as attractors to pedestrian interest and movement in order to stabilise the system and to enhance social interaction. The proposed analysis intends to insert a choreography of movements, flows and generic events within a simplified grid, thus creating a continuously evolving homeostatic event space.
Heat and mass transfer from the mantle: heat flow and He-isotope constraints

Terrestrial heat flow density, q, is inversely correlated with the age, t, of tectono-magmatic activity in the Earth’s crust (Polyak and Smirnov, 1966; etc.). «Heat flow-age dependence» indicates unknown temporal heat sources in the interior considered a priori as the mantle-derived diapirs. The validity of this hypothesis is demonstrated by studying the helium isotope ratio, 3
Impact of Import and Export on GDP of Egypt: Application of ARDL Model

This paper examines the applications of Autoregressive Distributed Lag (ARDL) model in the analysis of Egypt? s import and export data concerning the consequential impacts on the country? s Gross Domestic Product (GDP) between 1980 to 2010 years. Given that exports and imports significantly impact the economic status of Egypt through the balance of payment, it is therefore vital for policymakers to adequately comprehend and understand the factors affecting the revenue of the country? s economy. The study provides a wide range of elasticity estimates made from the data collected in the field. Moreover, this paper seeks to examine the current estimated import and export demand function for Egypt by employing the ARDL approach using the Eviews program. The results from ARDL approach analysis agrees with the hypothesis that Egypt has a long run relationship with export, import demand, economic growth prices of exports and imports, and volatility of an actual effective exchange rate in the market. Therefore, the imports and exports in Egypt are affected by the country? s GDP. Hence it is growth driven.
The Dyad Physical/Virtual Stores in the New Markets

This article aims to present the new role of physical retail stores in view of the current increase in e-commerce in Brazil, the so called “virtual stores”. This is a very important theme for the sector, which will define the future of traditional retailing. Exploratory research was conducted in books, periodicals and other printed material pertaining to the subject. It was concluded that the understanding of the current scenario of retail and knowledge of the rapid growth of e-commerce are relevant factors to define new guidelines for retailers with physical stores. Another important factor observed in the study was that traditional retailers need to understand that customers have changed, they are increasingly aware of their rights and are more prepared to claim them, which makes these new consumers confident to make purchases through the Internet. Thus, these factors will be important to define the new position of traditional retail because the only certainty is that physical stores will have to reinvent themselves if they want to stay in business.
Atomic-scale positioning of single spins via multiple nitrogen-vacancy centers

We present a scheme of positioning a single electron spin with sub-nanometer resolution through multiple nitrogen-vacancy centers in diamond. With unwanted noise suppressed by dynamical decoupling, the spin coherence of each center develops characteristic oscillations due to a single electron spin located $4{\sim20}$ nm away from the centers. We can extract the position information from the characteristic electron spin-coherence oscillations of each center. This scheme is useful for high-resolution nanoscale magnetometry and spin-based quantum computing.
Relative Efficiency of DCC Estimates via Different Algorithms

Volatility plays an important role in capturing the variability in any series, hence multivariate volatility models helps us in figuring out the spillovers across variables. The observation of such spillovers plays a very crucial role in financial decision making. Starting from the pioneering works of [1] and [2] ARCH/ GARCH type models and their multivariate extensions are widely used for capturing volatility spillovers. Dynamic Conditional Correlation (DCC) model proposed by [3] is one of the most widely used multivariate GARCH model. As GARCH type models are non - linear in nature, hence their solutions vary across the algorithms used for their computation. Different algorithms are used in different software and thus give varying results. In this study, we are going to compute and compare DCC model estimates through different software. In our study SAS results would be considered as baseline estimates and the competing results would be obtained from Stata and R. We will model the DCC estimates between returns on NYSE and PSX indices data for the time period of September 2001 to August 2016.This study would help us to determine the relative efficiency and accuracy of algorithms used for estimating the DCC model.
Conformational Search on the Tripeptides Structure by Molecular Dynamics:Study of L,L-Gly-Phe-Phe, L,L-Phe-Gly-Phe, and L,L-Phe-Phe-Gly

Natural oligopeptides comprise of 2-50 amino acid residues and present in virtually all living organisms. Despite the fact that several functions of these peptides are known, the exact nature of mechanistic activity need to be identified through dissecting conformational and structural details. In this study, we performed conformational analysis using molecular dynamics (MD) simulation in order to study the dynamic behavior of three tripeptides: L,LGly- Phe-Phe (commercial), L,L-Phe-Gly-Phe, and L,L-Phe-Phe-Gly in explicit water model.