Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation and Social Work Practice

Introduction - Joyce Lishman Evidence for Practice - Ian Shaw A Perspective on Empirical Practice - William J Reid and Pamela Zettergren Qualitative Practice Evaluation - Nick Gould Evaluation and Empowerment - Karen Dullea and Audrey Mullender Collaborative Evaluation with Service Users - Clare Evans and Mike Fisher Feminist Evaluation - Beth Humphries Histories in Social Work - Ruth R Martin Work in Progress - Karen Tanner and Pat Le Riche Interviewing and Evaluating - Jan Fook, Robyn Munford and Jackie Sanders Qualitative Clinical Research and Evaluation - Roy Ruckdeschel Single-System Evaluation - Martin Bloom Behavioural and Cognitive Interventions - Maurice Vanstone
Distributed cooperative UAV loss detection and auto-replacement protocol with guaranteed properties

In this paper, we explore the UAV loss detection and auto-replacement scheme in a multi UAV system. The developed scheme is based on the concept of cooperative multi UAV control, where the cooperation is achieved by broadcasting heartbeats (HBs) and information fusion technology. We first propose the UAV loss detection method by checking the HB time. Subsequently, we present the UAV auto-replacement which is based on a contention protocol. Next, we propose the recovery algorithm for the lost UAV rejoining the UAV group. Finally, case studies are given to demonstrate the proposed scheme.
Efficient and practical determination of grasping configurations for anthropomorphic hands

Abstract The paper presents a methodology to rapidly solve the inverse kinematics of anthropomorphic hands, which is particularized for a mechanical hand considering 27 degrees of freedom. Given the contact points and normal directions on an object surface, the proposed algorithm finds the joint values and the wrist position and orientation that make the fingertips satisfy the contact constraints. The approach combines an iterative algorithm with an off-line analysis that allows significant reductions of the execution time. The approach has been implemented and the paper includes application examples. The effectiveness and fast execution of the algorithm is demonstrated with statistical results.
An electron microscope study of dinoflagellate flagella.

SUMMARY: The two flagella of the dinoflagellates examined possess the normal axoneme structure with 9+2 filaments, the nine outer doublets forming triplets in the basal region. Unlike other flagella which possess one basal disc, the dinoflagellates have two basal discs and two diaphragms in the transition region. The two flagella differ from each other in their external morphology and extra-axonemal structures. The longitudinal flagellum contains much packing material in its proximal two-thirds, whereas the distal third contains only the axoneme. This flagellum bears short fine hairs. The transverse flagellum differs from any other type which has been described. It has a helical ribbon-like form due to the presence of a striated strand, which is shorter than the axoneme, and an expanded sheath. It also bears long fine hairs in a unilateral array. The distal end of this flagellum is attached to the cell in the region of the flagellar bases. The structure of the two flagella appears to be compatible with their respective forms of movement.
Smart Distribution Networks: A Review of Modern Distribution Concepts from a Planning Perspective

Smart grids (SGs), as an emerging grid modernization concept, is spreading across diverse research areas for revolutionizing power systems. SGs realize new key concepts with intelligent technologies, maximizing achieved objectives and addressing critical issues that are limited in conventional grids. The SG modernization is more noticeable at the distribution grid level. Thus, the transformation of the traditional distribution network (DN) into an intelligent one, is a vital dimension of SG research. Since future DNs are expected to be interconnected in nature and operation, hence traditional planning methods and tools may no longer be applicable. In this paper, the smart distribution network (SDN) concept under the SG paradigm, has presented and reviewed from the planning perspective. Also, developments in the SDN planning process have been surveyed on the basis of SG package (SGP). The package presents a SDN planning foundation via major SG-enabling technologies (SGTF), anticipated functionalities (SGAF), new consumption models (MDC) as potential SDN candidates, associated policies and pilot projects and multi-objective planning (MOP) as a real-world optimization problem. In addition, the need for an aggregated SDN planning model has also been highlighted. The paper discusses recent notable related works, implementation activities, various issues/challenges and potential future research directions; all aiming at SDN planning.
Changes Associated with Long-Term Oral Administration of the Penem Antibiotic FCE 22891 to Rats and Monkeys with Particular Emphasis on the Urinary Tract and the Urine

FCE 22891, a synthetic β-lactam antibiotic of the penem class, was administered by gavage to Sprague-Dawley rats and cynomolgus monkeys for 26 wk (with and without a 6-wk recovery). Rats received the test material at doses of 0, 200, 500, and 1,250 mg/kg/day, and monkeys were given doses of 0, 100, 200, 400, and 600 mg/kg/day. At the end of the 26-wk treatment period, approximately two-thirds of the animals (both species) were sacrificed, and the remaining animals were held without treatment for a further 6 wk. A treatment-related mortality occurred in female monkeys receiving 600 mg/kg. There was a reduction in body weight gain in the high-dose groups of both species. Male rats were more affected than the females and, conversely, female monkeys were affected more than the males. At higher dose levels, both species exhibited an early, but transient, azotemia and oliguria with an increase in specific gravity and reduced pH. In rats, microscopic examination revealed treatment-related renal cortical tubular degenerative and regenerative changes with associated interstitial inflammation and fibrosis and diffuse urothelial hyperplasia in the urinary bladder. In general, female rats were less severely affected, and in both sexes there was a trend to recovery of most of these effects. In monkeys given 600 mg/kg of the test material, renal cortical tubular degeneration was seen only in those females that died in the first 5 wk of dosing. In other animals at this dose level, the renal lesions were determined to be reversible.
The EngD Second Year Report Ben Tagger October 18 , 2006 Preliminary EngD Title : A Framework for Managing Changes in Biological Data Starting Date : 27 th September 2004 1 st Supervisor

Disclaimer: This report is substantially the result of my own work except where explicitly indicated. This report must not be copied or distributed due to the sensitive nature of the material contained herein. The biological datasets and related findings documented within this report are confidential and owned by a scientific consortium. Therefore, they should not form the subject of further work without the explicit permission of the consortium.
The ZIP7 Gene (Slc39a7) Encodes a Zinc Transporter Involved in Zinc Homeostasis of the Golgi Apparatus*

It has been suggested that ZIP7 (Ke4, Slc39a7) belongs to the ZIP family of zinc transporters. Transient expression of the V5-tagged human ZIP7 fusion protein in CHO cells led to elevation of the cytoplasmic zinc level. However, the precise function of ZIP7 in cellular zinc homeostasis is not clear. Here we report that the ZIP7 gene is ubiquitously expressed in human and mouse tissues. The endogenous ZIP7 was associated with the Golgi apparatus and was capable of transporting zinc from the Golgi apparatus into the cytoplasm of the cell. Moreover, by using the yeast mutant strain Δzrt3 that was defective in release of stored zinc from vacuoles, we found that ZIP7 was able to decrease the level of accumulated zinc and in the meantime to increase the nuclear/cytoplasmic labile zinc level in the ZIP7-expressing zrt3 mutant. We showed that the protein expression of ZIP7 was repressed under zinc-rich condition, whereas there were no effects of zinc on ZIP7 gene expression and intracellular localization. Neither did zinc deficiency affect the intracellular distribution of ZIP7 in mammalian cells. Our study demonstrates that ZIP7 is a functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell.
Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.

BACKGROUND & AIMS The concept of a CpG island methylator phenotype (CIMP), especially in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a large population-based sample of individuals with colon cancer and used univariate and multivariate analyses of CIMP with clinicopathologic variables and tumor mutations to determine the biologic relevance of this phenotype. METHODS A total of 864 tumors from individuals with colon cancer from Utah and Northern California were evaluated by methylation-specific polymerase chain reaction of CpG islands in hMLH1, methylated in tumors (MINT) 1, MINT 2, MINT 31, and CDKN2A (p16). CIMP high was defined as methylation at 2 or more of these loci. The BRAF V600E mutation was determined by sequencing. Microsatellite instability had been determined previously. RESULTS In a multivariate analysis of microsatellite stable tumors, CIMP high was related significantly to the V600E BRAF mutation (odds ratio, 39.52; 95% confidence interval, 11.44-136.56), KRAS2 mutations (odds ratio, 2.22; 95% confidence interval, 1.48-3.34), older age (P trend = .03), and increased stage (P trend = .03), and these tumors were less likely to be located in the distal colon (odds ratio, .42; 95% confidence interval, .27-.65). CIMP-high unstable tumors also were more likely to have the V600E BRAF mutation, be located proximally, and occur in older individuals (in univariate analyses). However, CIMP-high unstable tumors were significantly more likely than their stable counterparts to be KRAS2 wild type, TP53 wild type, poorly differentiated, proximally located, occur at lower stages, and have the BRAF V600E mutation (64.1% vs 17.6%). CONCLUSIONS The evaluation of a large, population-based sample strongly supports the biologic relevance of CIMP in colon cancer. However, the presence or absence of microsatellite instability has a major effect on the expression of this phenotype.
A Role of Intestine in Hypertension: Mechanism of Suppression of Intestinal Na-H Exchanger Isoform-3 in Spontaneously Hypertensive Rats

The main objective of this study was to investigate the role and the underlying mechanism of Na-H exchanger-3 (NHE-3) expression in spontaneously hypertensive rat (SHR) intestine. Expression of colonic and ileal NHE-3 isoform, its regulatory factor-1 (NHERF-1) and cyclic GMP kinase II (cGKII) were examined using western blot analysis. Since NHE-3 activity is regulated by its abundance on the plasma membrane, its levels were also examined in lipid rafts-enriched membrane fractions. The lipid rafts fractions were characterized by examining the concentration of flotillin-1 and caveolin-1, total protein, and cholesterol. Twelve-weeks-old SHR used in this study developed significant hypertension, proteinuria, and renal and cardiac hypertrophy. These changes were significantly reversed by captopril treatment. There was a significant decrease in the levels of NHE-3 and NHERF-1 proteins, and sodium pump activity, but an increase in the cGKII levels in both tissues from SHR. Reduction in NHERF-1 levels was reversed by captopril but not of the other proteins. Cholesterol profile was significantly different in SHR colon as compared to normo-tensive Wistar Kyoto rats. These findings suggest that suppression of NHE-3 in intestine is a counteracting mechanism of hypertension and is regulated by NHERF-1 through cGKII activation in SHR. NHE-3 suppression together with decrease in the sodium pump activity would accumulate intracellular Na+ and may contribute to the reported hypertension-induced tissue damage in the GI-tract.
Regulatory role of C‐terminus in the G‐protein coupling of the metabotropic glutamate receptor 1

The signaling property of metabotropic glutamate receptor 1α (mGlu1α) is different from that of short‐form splice variants. This could be caused by the exposure of a cluster of positively charged amino acid residues, RRKK, in the proximal C‐tail which is thought to be masked by the long C‐tail of mGlu1α. We found that the RRKK residues, when exposed, attenuate Gq coupling and decrease the basal activity and the surface expression of mGlu1, in agreement with previous results. Moreover, these residues abolish the Gi/o coupling of mGlu1, but do not affect glutamate‐induced dimeric rearrangement and protein kinase A‐dependent modulation of mGlu1. These results suggest that the RRKK residues do not inhibit the conformational change upon glutamate binding and protein accessibility to the intracellular loops where G‐protein coupling occurs, but rather act as an inhibitory domain against G‐protein coupling in a different manner depending on the type of G protein.
Is an imbalance between physical capacity and exposure to work-related physical factors associated with low-back, neck or shoulder pain?

OBJECTIVES This study investigates whether an imbalance between physical capacity and exposure to work-related physical factors is associated with low-back, neck, or shoulder pain. METHODS Data of the longitudinal study on musculoskeletal disorders, absenteeism, stress, and health (SMASH), with a follow-up of 3 years (N=1789), were used. At baseline, physical capacity (isokinetic lifting strength, static muscle endurance, and mobility of the spine) and exposure to work-related physical factors were assessed. During the follow-up, low-back, neck, and shoulder pain were self-reported annually. "Imbalance" was defined as lower than median capacity combined with higher than median exposure, "high balance" was high capacity and high exposure, and "low balance" was low capacity and low exposure. RESULTS For both the low-back and neck, imbalance between static endurance and working with flexed postures was a risk factor for pain [relative risk (RR) 1.35, 95% confidence interval (95% CI) 1.08-1.68, and RR 1.36, 95% CI 0.96-1.91, respectively]. Low balance was also associated with low-back pain (RR 1.29, 95% CI 1.04-1.68). Furthermore, low balance between isokinetic lifting strength and lifting exposure was a risk factor for low-back and neck pain [RR between 1.22 (95% CI 0.99-1.49) and 1.35 (95% CI 1.03-1.79)]. No associations were found with shoulder pain. CONCLUSIONS Some relationship between low-back and neck pain and combined measures of physical capacity with exposure to work-related physical factors seems to exist, but an imbalance between physical capacity and exposure was not found to yield higher risks than high balance or low balance.
PENGGUNAAN MEDIA ANIMASI DALAM MENINGKATKAN AKTIVITAS BELAJAR MATEMATIKA SISWA KELAS VIII SMP NEGERI 3 GALING

This study aims to determine the increase in activity of the class VIII student learning through the use of animation media in SMP Negeri 3 Galing. The method used in this research is a classroom action research method. The subjects were eighth grade students of SMP Negeri 3 Galing, amounting to 24 students. Activity indicators studied were listening to the teacher's explanation, ask the teacher, answering questions from the teacher, responding to friend answers, present work and do every test given. Analysts of the observations show an increase in students' learning activities through the use of animation media in learning mathematics. This study demonstrated increased activity with percentage value of learning activities of 80% (very active).
Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital.

AIM To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients. METHODS In total, 789 consecutive outpatients referred for gastrointestinal (GI) endoscopy [381 for esophagogastroduodenoscopy (EGD) and 408 for colonoscopy] were prospectively enrolled in the study. The American Society for Gastrointestinal Endoscopy (ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic findings. RESULTS The overall inappropriate rate was 13.3%. The indications for EGD and colonoscopy were, respectively, appropriate in 82.7% and 82.6% of the exams, uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%. The diagnostic yield was significant higher for EGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate (EGD: 36.6% vs 36.4% vs 11.4%, P = 0.004; Colonoscopy: 24.3% vs 20.0% vs 3.3%, P = 0.001). Of the 25 malignant lesions detected, all but one was detected in exams judged appropriate or uncertain. CONCLUSION This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations, namely in detecting neoplastic lesions. It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures.
A Group Decision-Making Framework with Various Rating Attitudes using Fuzzy Set Theory to Prioritize Design Requirements in Quality Function Deployment

A structured method is called quality function deployment (QFD) that translates the voice of the customer into both of the product and service development. The architecture of QFD is composed of a set of matrices that is often referred to as the house of quality (HOQ). HOQ is regarded as a part of the QFD process. The matrices of HOQ include the importance of customer requirements and the relationship between customer requirements and design requirements collected by the decision-making process of a group of people with ambiguousness and fuzziness. Besides, a group of people make decisions to evaluate fuzzy information with different rating or risk-taking attitudes such as optimistic, neutral, and conservative attitudes. Therefore, a group decision-making framework with various rating attitudes using fuzzy set theory can be used in QFD to identify the importance of each design requirement. Furthermore, a numerical example is solved to show that this group decision-making framework with risk-taking attitudes using fuzzy set theory can be accurately and convincingly applied in QFD for prioritizing design requirements with diverse rating attitudes to help the companies increase customer satisfaction and market share.
Cutaneous blood flow rate in areas with and without arterovenous anastomoses during exercise

In 10 healthy subjects, skin blood flow rate was measured in the thumb pulp by the heat‐washout method, and in the skin fold between the thum and the forefinger by the 133Xe‐washout method. The former but not the latter skin area contains arterovenous anastomoses (AVAs). In response to 10 min moderate cycle exercise, an instantaneous decrease in flow was seen in the thumb pulp followed after about 4.6 min by an increase to resting levels. Blood flow in the skin fold remained constant. The results indicate that the initial reduction in blood flow rate and later increase observed in the finger at the onset of moderate exercise take place in the AVAs and not in the capillaries.
Optimized metrology for laser-damage measurement: application to multiparameter study.

An automatic test apparatus for refined testing of laser damage is presented that permits an in situ analysis of the tested area before, during, and after pulsed irradiation. Spatial and temporal beam profiling are performed in real time and give access to the localized fluence for each shot. Furthermore, an optimization of the initiation of damage detection is undertaken by use of image processing and yields a resolution better than 1 microm. Through several examples, these conditions are demonstrated to be useful for reaching an understanding of the laser-damage process. A complete study is undertaken of different kinds of glass that permits the main influence of test parameters (shot frequency, shot number, beam profile variation, temporal and spatial meshing, .) on the damage procees to be shown. The study was made for different test procedures (1:1, S:1, R:1) and completed by atomic-force microscope analysis. Evidence indicates that the upgrading of metrology associated with an automatic process offers new opportunities for understanding laser-induced damage mechanisms and for emphasizing specific effects such as damage initiation, damage growth, and conditioning for repetitive shots.
Differences in and correlations between cognitive abilities and brain volumes in healthy control, mild cognitive impairment, and Alzheimer disease groups

The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis—cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM)—were acquired. Of the CERAD‐K subtests, the Boston Naming Test distinguished significantly among the HC, MCI, and AD groups. GM and WM volumes differed significantly among the three groups. There was a significant positive correlation between Boston Naming Test scores and GM and WM volumes. In conclusion, the Boston Naming Test and GM and WM brain volumes differentiated the three tested groups accurately, and there were strong correlations between Boston Naming Test scores and GM and WM volumes. These results will help to establish a test method that differentiates the three groups accurately and is economically feasible. Clin. Anat. 29:473–480, 2016. © 2016 Wiley Periodicals, Inc.
Interaction of platelets with liposomes containing dodecapeptide sequence from fibrinogen

Summary Liposomes with a covalently bound synthetic peptide containing the dodecapeptide sequence HHLGGAKQAGDV, the putative platelet interaction site at γ400-411 of fibrinogen (dodecapeptide-liposomes), were prepared. These liposomes enhanced platelet aggregation and specifically adhered to platelets activated on the collagen surface. Dodecapeptide-liposomes released encapsulated materials upon interacting with platelets activated on the collagen surface.The rate of content release was dependent on the peptide surface density, indicating that the interaction between the dodecapeptide-liposomes and platelets activated on the collagen surface induces clustering of the surfacecoupled ligands at the binding site on the receptor matrix to facilitate release of the internal contents through the liposome membranes. The level of lipid mixing between the dodecapeptide-liposomes and platelets activated on the collagen surface was relatively low, however it was increased in liposome preparations containing octa-arginine, the (R)8GDV sequence, while content release was maintained at the same level as that of the dodecapeptide-liposomes. The level of content release and lipid mixing for liposome preparations containing the RGD sequence as a ligand (RGD-liposomes) upon interacting with platelets activated on the collagen surface was extremely low. Both the level of the content release and lipid mixing, however, were enhanced in liposome preparations containing octa-arginine, the (R)8RGD sequence. Dodecapeptide-liposomes and RGD-liposomes were not internalized by activated platelets. On the other hand, liposomes containing (R)8PPQ, (R)8RGD, or (R)8GDV were internalized by activated platelets, and the extent of internalization was inversely related to ligand affinity to the target.