Miracle-dz/UniFAR-FTUs huggingface dataset:
BABD: A Bitcoin Address Behavior Dataset for Pattern Analysis

Cryptocurrencies have dramatically increased adoption in mainstream applications in various fields such as financial and online services, however, there are still a few amounts of cryptocurrency transactions that involve illicit or criminal activities. It is essential to identify and monitor addresses associated with illegal behaviors to ensure the security and stability of the cryptocurrency ecosystem. In this paper, we propose a framework to build a dataset comprising Bitcoin transactions between 12 July 2019 and 26 May 2021. This dataset (hereafter referred to as BABD-13) contains 13 types of Bitcoin addresses, 5 categories of indicators with 148 features, and 544,462 labeled data, which is the largest labeled Bitcoin address behavior dataset publicly available to our knowledge. We also propose a novel and efficient subgraph generation algorithm called BTC-SubGen to extract a ${k}$ -hop subgraph from the entire Bitcoin transaction graph constructed by the directed heterogeneous multigraph starting from a specific Bitcoin address node. We then conduct 13-class classification tasks on BABD-13 by five machine learning models namely ${k}$ -nearest neighbors algorithm, decision tree, random forest, multilayer perceptron, and XGBoost, the results show that the accuracy rates are between 93.24% and 97.13%. In addition, we study the relations and importance of the proposed features and analyze how they affect the effect of machine learning models. Finally, we conduct a preliminary analysis of the behavior patterns of different types of Bitcoin addresses using concrete features and find several meaningful and explainable modes.
EVALUATION OF ISLAMIC MANAGEMENT OF BEEF CATTLE DEVELOPMENTPROGRAM OF LEMBAGA MANDIRI MENGAKAR MASYARAKAT :CASESTUDY IN PESANTREN AL MAWADDAH WARRAHMAH KOLAKA - SULAWESI TENGGARA

The purpose of the research were to analyze the level of achievement of islamic management on beef cattle development program of Lembaga Mandiri Mengakar Masyarakat (LM3) in Pondok Pesantren Al Mawaddah Warrahmah Kolaka-Sulawesi Tenggara Case. The research was conducted January 2012-January 2016. Independent agencies are Rooted in the Community in Pondok Pesantren Al Mawaddah Warrahmah as respondent were selected. The data were statistically analyzed by descriptive analysis to analyze the achievement of the program. The result showed that the achievement level of amount of beef was high in periode 2012, 2013, 2014, and 2015 (75, 78.5, 75, and 88.88 % respectively), number of farmer was low (100, 100, 100, and 57.4% respectively) from its target, profit sharing was high (Rp.10.425.000, Rp.16.700.000, Rp.17.500.000, dan Rp.21.025.000). ). That can be concluded that program of independent agencies are rooted in the community (LM3) in Pondok Pesantren Al Mawaddah Warrahmah case is effective.
BB0761, a MepM homolog, contributes to Borrelia burgdorferi cell division and mammalian infectivity

M23 family endopeptidases play important roles in cell division and separation in a wide variety of bacteria. Recent studies have suggested that these proteins also contribute to bacterial virulence. However, the biological function of M23 peptidases in pathogenic spirochetes remains unexplored. Here, we describe Borrelia burgdorferi, the bacterial pathogen causing Lyme disease, requires a putative M23 family homolog, BB0761, for spirochete morphology and cell division. Indeed, the inactivation of bb0761 led to an aberrant filamentous phenotype as well as the impairment of B. burgdorferi growth in vitro. These phenotypes were complemented not only with B. burgdorferi bb0761, but also with the mepM gene from E. coli. Moreover, the bb0761 mutant showed a complete loss of infectivity in a murine model of Lyme borreliosis. Resistance of the mutant to osmotic and oxidative stresses was markedly reduced. Our combined results indicate that BB0761 contributes to B. burgdorferi cell division and virulence.
Implementation of the configurable fault tolerant system experiment on NPSAT-1

Abstract : Space is a harsh environment, full of high-energy radiation that can cause single-event effects (SEE) in orbiting satellites. Some of these effects, such as single-event upsets and single-event functional interrupts, occur when ionizing radiation causes the logical value in a memory element to change and are detectable and correctable through various error mitigation techniques. In this thesis, we develop and implement a hardware solution to combat these SEE for deployment as an experimental module on Naval Postgraduate School Satellite 1 (NPSAT-1). Based on the relatively benign orbit of NPSAT-1, industrial-grade, commercial-off-the-shelf components that have shown tolerance to radiation were selected to keep costs low. The primary source of mitigation relies on a globally triple-modular redundant microprocessor system instantiated inside of a XILINX Kintex-7 field-programmable gate array. The system consists of an open-source microprocessor without interlocked pipeline stages (MIPS) based processor softcore, a cached memory structure capable of accessing double-data rate type three and secure digital card memories, an interface to the main satellite bus, and XILINXs soft error mitigation softcore. The hardware was tested both in and out of the system and verified to work on the ground with faults injected. Other techniques to mitigate errors due to SEE, such as memory scrubbing, are intended to be added before launch.
carba-Nucleopeptides (cNPs): A Biopharmaceutical Modality Formed through Aqueous Rhodamine B Photoredox Catalysis.

Exchanging the ribose backbone of an oligonucleotide for a peptide can enhance its physiologic stability and nucleic acid binding affinity. Ordinarily, the eneamino nitrogen atom of a nucleobase is fused to the side chain of a polypeptide through a new C-N bond. The discovery of C-C linked nucleobases in the human transcriptome reveals new opportunities for engineering nucleopeptides that replace the traditional C-N bond with a non-classical C-C bond, liberating a captive nitrogen atom and promoting new hydrogen bonding and π-stacking interactions. We report the first late-stage synthesis of C-C linked carba-Nucleopeptides (cNPs) using aqueous Rhodamine B photoredox catalysis. We prepare brand-new cNPs in batch, in parallel, and in flow using three long-wavelength photochemical setups. We detail the mechanism of our reaction by experimental and computational studies and highlight the essential role of diisopropylethylamine as a bifurcated two-electron reductant.
Lithium use associated with symptom severity in comorbid bipolar disorder I and migraine

Bipolar disorder (BD) and migraine headaches are frequently comorbid. The common etiological features are unknown, however cortical hyperexcitability (EEG) of migraines, and the report of hyperexcitability in pluripotent stem cell‐derived neurons from lithium responsive BD subjects offers a physiological hypothesis of excitable neurons linking these disorders. However, clinical studies suggest that a history of migraine is associated with higher rates of relapse in those with BD taking lithium. Lithium use and history of migraine in this prospective longitudinal study of BD find that lithium use is associated with a greater symptom severity in BD.
Daratumumab in amyloidosis.

Light chain amyloidosis has come far with the first ever treatment to get regulatory approval in 2021. Daratumumab based regimes achieve deep hematologic and organ responses; offering a new therapeutic backbone. Early identification, correct fibril typing, challenges of the very advanced patient and lack of therapies to remove amyloid deposits remains under study but as yet elusive. We review the progress of treatment in AL amyloidosis, the impact of daratumumab and look towards the next steps.
A novel approach to the design and implementation of dual-band compact planar 90° branch-line coupler

This paper presents the design of a novel branch-line coupler that can operate at two arbitrary frequencies. The proposed circuit also features compact size and planar structure. Explicit design formulas of the proposed dual-band coupler are analytically derived. Moreover, practical issues such as the realization of branch-line impedance and optimum choice of circuit topologies are addressed. For verification purposes, both simulated and measured results of a microstrip branch-line coupler operating at 900/2000 MHz are included.
Contribution of Lean Mass Distribution on Aerobic Fitness and Performance in NCAA Division I Female Rowers

Abstract Haraldsdottir, K, Sanfilippo, J, Dawes, S, and Watson, A. Contribution of lean mass distribution on aerobic fitness and performance in NCAA division I female rowers. J Strength Cond Res 36(7): 1956–1960, 2022—The purpose of this study was to determine the relative influence of total lean body mass (LBM), body fat percentage (BF%), upper extremity lean mass (ULM), lower extremity lean mass (LLM), and trunk lean mass (TLM) on maximal aerobic capacity (V̇o2max) and time to exhaustion (Tmax) in female collegiate rowers. One hundred seven female collegiate rowers (aged 18–22 years) performed maximal progressive rowing ergometer testing to determine V̇o2max and Tmax. Body mass, LBM, BF%, ULM, LLM, and TLM were determined by using dual-energy x-ray absorptiometry. Separate multivariable linear regression models were performed to predict V̇o2max and Tmax by using LBM and BF% as predictors. In addition, separate linear regression models were used to predict V̇o2max and Tmax with ULM, LLM, and TLM as covariates. Subjects were aged 20 ± 3 years. V̇o2max was significantly predicted by LBM (r2 = 0.29, p < 0.001), but not BF% (r2 = 0.002, p = 0.79). Similarly, Tmax was significantly predicted by LBM (r2 = 0.25, p < 0.001), but not BF% (r2 = 0.003, p = 0.19). V̇o2max was significantly predicted by LLM (r2 = 0.12, p < 0.01), but not ULM (r2 = 0.08, p = 0.68) or TLM (r2 = 0.09, p = 0.17), and Tmax was significantly predicted by TLM (r2 = 0.09, p = 0.02), but not ULM (r2 = 0.07, p = 0.89) or LLM (r2 = 0.08, p = 32). Among female collegiate rowers, whole body LBM is a significant predictor of both V̇o2max and Tmax. However, LLM is a stronger predictor of V̇o2max while TLM is a stronger predictor Tmax, although each of these relationships has a low coefficient of determination. These findings suggest that aerobic fitness and performance may be influenced by regions of lean mass differently.
Prevalence of alcohol and other drug use in patients presenting to hospital for fall-related injuries: a systematic review

Background Alcohol and other drug (AOD) use is a key preventable risk factor for serious injuries. Prevention strategies to date have largely focused on transport injuries, despite AOD use being a significant risk factor for other injury causes, including falls. This systematic review aimed to report the prevalence of AOD use in patients presenting to hospital for fall-related injuries. Methods This systematic review includes studies published in English after the year 2010 that objectively measured the prevalence of AOD use in patients presenting to hospital for a fall-related injury. Screening, data extraction and risk of bias assessments were completed by two independent reviewers. Data were presented using narrative synthesis and, where appropriate, meta-analyses. Results A total of 12 707 records were screened. Full texts were retrieved for 2042 records, of which 29 were included. Four studies reported the combined prevalence of any alcohol and/or drug use, generating a pooled prevalence estimate of 37% (95% CI 25% to 49%). Twenty-two records reported on the prevalence of acute alcohol use alone and nine reported specifically on the prevalence of drugs other than alcohol, with prevalence ranging from 2% to 57% and 7% to 46%, respectively. The variation in prevalence estimates likely resulted from differences in toxicology testing methods across studies. Conclusions AOD exposure was common in hospitalised fall-related injuries. However, research addressing prevalence across different types of falls and the use of drugs other than alcohol was limited. Future research should address these areas to improve our understanding of which populations should be targeted in AOD and injury prevention strategies . PROSPERO registration number CRD42020188746.
Recent progress in microwave-assisted preparations of 2D materials and catalysis applications

On the urgency of metal-free catalysts, two-dimensional materials (2DMs) have caused extensive researches because of distinctive optical and electronic properties. In the last decade, microwave methods have emerged in rapid and effective preparations of 2DMs for catalysis. Microwave heating offers several advantages namely direct, fast, selective heating and uniform reaction temperature compared to conventional heating methods, thus bringing about high-yield and high-purity products in minutes or even seconds. This review summarizes recent advances in microwave-assisted preparations of 2DMs-based catalysts and their state-of-the-art catalytic performances. Microwave heating mechanisms are briefly introduced mainly focusing on microwave-matter interactions, which can guide the choice of precursors, liquid media, substrates, auxiliaries and experiment parameters during microwave radiation. We especially provide a detailed insight into various microwave-assisted procedures, classified as exfoliation, synthesis, doping, modification and construction towards different 2DMs nanomaterials. We also discuss how microwave affects the synthetic composition and microstructure of 2DMs-based catalysts, thereby deeply influencing their optical and electronic properties and the catalytic performances. Finally, advantages, challenges and prospects of microwave-assisted approaches for 2DMs nanomaterials are summarized to inspire the effective and large-scale fabrication of novel 2DMs-based catalysts.
Insulin peptides and their receptors regulate ovarian development and oviposition behavior in Diaphorina citri

Diaphorina citri is an important vector of Citrus Huanglongbing (HLB) disease. After feeding on young host plant shoots, the population of D. citri can increase significantly. Females also only lay eggs on young shoots. However, there are few studies on the mechanism of this phenomenon. Exogenous nutrient signals can affect the insulin signaling system of D. citri after feeding on young shoots. In this study, the expression of upstream factors DcILP1, DcILP2, and DcIR in the insulin signaling system of D. citri was upregulated after feeding on young shoots. After being silenced by RNA interference technology, the results showed that the number of oviposited eggs of D. citri was significantly decreased and the ovarian development was inhibited with severe vacuolation. In addition, detection using quantitative reverse transcription–polymerase chain reaction showed that the upstream regulatory gene DcRheb of the target of rapamycin (TOR) pathway and the downstream reproduction‐related DcVg gene were also significantly downregulated. These results suggest that feeding upon young shoots may upregulate the expression levels of upstream factors DcILP1, DcILP2, and DcIR in the insulin signaling system. The signal will be through upregulating the expression of DcRheb, an upstream gene of the TOR signaling pathway. This in turn influences yolk metabolism, which eventually causes the ovaries of female D. citri to mature and therefore initiate oviposition behavior.
Verification of surface electromyographic activity of the oblique externus abdominis using ultrasound shear wave elastography

This study used ultrasound shear wave elastography (SWE) to revalidate whether surface electromyographic (EMG) electrodes placed on the oblique externus abdominis (OE) can detect only the OE activity without the confounding activity of the underlying oblique internus abdominis (OI). During left and right trunk rotations, the EMG activity was acquired using surface EMG electrodes placed on the right OE. Shear wave velocity (Vs) values of the right OE and OI were acquired using SWE. The EMG activity during the left and right trunk rotations significantly increased as the level of exertion increased (25%, 50%, 75%, and 100% of the one‐repetition maximum [1RM]). The Vs of the right OE was significantly different only between 25% and 75% 1RM in the right trunk rotation, but significantly increased from 25% to 75% 1RM during the left trunk rotation. The Vs of the right OI during the right trunk rotation significantly increased with increased levels of exertion, except between 50% and 75% 1RM. The results for the Vs of the OE and OI in the right trunk rotation suggest that surface EMG electrodes placed on the OE would detect not only the antagonistic OE activity but also the agonistic OI activity.
Prevalence of infantile wheezing and eczema in a metropolitan city in Japan: A complete census survey

Infantile wheezing and eczema are associated with the subsequent onset of asthma and other atopic diseases. However, there are no large population-based surveys on infantile allergic symptoms in Japan. The objective of the study was to determine the prevalence of wheezing and asthma in infants in Nagoya, Japan. This population-based cross-sectional study was performed in the metropolitan city of Nagoya, Japan. We surveyed parents to ascertain the prevalence of wheezing and eczema in infants who attended group health checkups at 3, 18, and 36 months of age. Their parents completed modified questionnaires from the International Study of Asthma and Allergies in Childhood. More than 90% of the approximately 40,000 children in each study group living in the target area were included in the survey. The prevalence of wheezing was 8%, 17%, and 13% at 3, 18, and 36 months, respectively, and was characterized by birth season. The prevalence of eczema was 24%, 30%, and 31%, at 3, 18, and 36 months, respectively. Participants born in autumn and winter had a higher incidence of eczema in each age group. Three-quarters of the children had a parental history of allergic conditions. Parental allergic diseases and male gender are risk factors for wheezing and eczema in children. This survey had a high response rate and covered almost the entire population of the target age groups in a large city. We believe that the results of this study, therefore, provide a much higher level of confidence regarding the prevalence of allergies in infants in Japan than that in previous studies with limited cohorts.
Arabidopsis RNA processing body components LSM1 and DCP5 aid in the evasion of translational repression during Cauliflower mosaic virus infection

Abstract Viral infections impose extraordinary RNA stress, triggering cellular RNA surveillance pathways such as RNA decapping, nonsense-mediated decay, and RNA silencing. Viruses need to maneuver among these pathways to establish infection and succeed in producing high amounts of viral proteins. Processing bodies (PBs) are integral to RNA triage in eukaryotic cells, with several distinct RNA quality control pathways converging for selective RNA regulation. In this study, we investigated the role of Arabidopsis thaliana PBs during Cauliflower mosaic virus (CaMV) infection. We found that several PB components are co-opted into viral factories that support virus multiplication. This pro-viral role was not associated with RNA decay pathways but instead, we established that PB components are helpers in viral RNA translation. While CaMV is normally resilient to RNA silencing, dysfunctions in PB components expose the virus to this pathway, which is similar to previous observations for transgenes. Transgenes, however, undergo RNA quality control-dependent RNA degradation and transcriptional silencing, whereas CaMV RNA remains stable but becomes translationally repressed through decreased ribosome association, revealing a unique dependence among PBs, RNA silencing, and translational repression. Together, our study shows that PB components are co-opted by the virus to maintain efficient translation, a mechanism not associated with canonical PB functions.
A three‐methylation‐driven gene–based deep learning model for tuberculosis diagnosis in patients with and without human immunodeficiency virus co‐infection

Improved diagnostic tests for tuberculosis (TB) among people with human immunodeficiency virus (HIV) are urgently required. We hypothesized that methylation‐driven genes (MDGs) of host blood could be used to diagnose patients co‐infected with HIV/TB. In this study, we identified three MDGs among patients with HIV monoinfection and those with HIV/TB co‐infection using the R package MethylMix. We then developed a deep learning model by screening these three MDGs, which distinguished HIV/TB co‐infection from HIV monoinfection with a sensitivity of 95.2% and a specificity of 88.3%. On the two independent data sets, the sensitivity and specificity were 80%–92.8% and 72.7%–87.5%, respectively. Besides, our deep learning model accurately classified TB (sensitivity, 75.0%–100%; specificity, 91.3%–98.1%) and other respiratory disorders (sensitivity, 72.7%–75.0%; specificity, 70.9%–72.7%). This study will contribute to improve molecular diagnosis for HIV/TB co‐infection.
Fractional CO2 laser versus microneedling as a transepidermal drug delivery system for the treatment of alopecia areata: A clinical dermoscopic evaluation

New treatment modalities are rising for better clinical improvement in alopecia areata. This work aims to evaluate the efficacy of fractional CO2 laser and microneedling as a transepidermal drug delivery in cases with alopecia areata. The study included 30 patients with alopecia areata. All lesions in each patient have received randomly two different treatment modalities, fractional CO2 laser or microneedling followed by triamcinolone acetonide (TA) application according to group assignment. Sessions were done every month for a maximum of six sessions or complete resolution. Response to treatment was assessed on SALT score and dermoscopic imaging. Both treatment modalities showed a significant clinical improvement of alopecia areata, with a statistically significant reduction of SALT score for fractional CO2 laser group and microneedling group (p value <0.001). Moreover, there is a significant difference in the SALT score between both modalities (p = 0.013), whereas the reduction of the SALT score was more evident in microneedling group. On comparing the dermoscopy findings in fractional CO2 laser and microneedling treated areas before and after treatment, a significant reduction was found regarding all dermoscopic findings of alopecia areata. Fractional CO2 laser and microneedling as a transepidermal drug delivery could be a novel and effective treatment modality in alopecia areata. Dermoscopy is very useful to identify disease activity and early signs of clinical improvement during treatment.