Miracle-dz/UniFAR-FTUs huggingface dataset:
Discovering hidden patterns among medicines prescribed to patients using Association Rule Mining Technique

ABSTRACT Hospital pharmacies are experiencing significant rise in demand for medicines for treatment and care of patients admitted to hospitals. Nevertheless, inefficient processes continue to be a problem in hospital pharmacy management, resulting in mismatch between demand and supply, time-consuming manual tasks, out-of-stock situations, medicine expiration, and excessive operating costs. Prior research has addressed various aspects of hospital pharmacy management, but limited studies have focused on discovering hidden patterns and knowledge from large volume of data stored in hospital information systems, which can help improve pharmacy operations. Primary goal of this research is to extract meaningful knowledge from hospital databases to improve pharmacy operations. Hospital pharmacy database from multispecialty hospital in India is used to examine associations among medicines prescribed to hospitalized patients using Apriori approach, which is one of the algorithms of Association Rule Mining. Data comprising 745,176 pharmaceutical item order records were gathered, processed and analyzed. Around sixty-three association rules were discovered. Different measures like support, confidence, and lift are used to evaluate the rules. Rule comprising medicines Atracurium, Febuxostat, and Multivitamins achieved the highest confidence of 87.35%. Discovered rules can help pharmacists to anticipate demand, develop better inventory system, improve operational efficiency and lead to effective healthcare system.
Multi-Heuristic Machine Intelligence Guidance in Automatic Test Pattern Generation

We present an automatic test pattern generation (ATPG) system using the PODEM (path-oriented decision making) algorithm where backtraces and D-drive are directed by composite heuristics. In a worked out illustration, three heuristic measures are combined by an unsupervised learning procedure of principal component analysis (PCA). The three measures for each signal node are distance (dPI and dPO or minimum distances to primary inputs and outputs), COP (controllability-observability program probabilities, CC0, CC1, and CO), and SCOAP (Sandia controllabilitiy-observability analysis program combinational testability measures, SC0, SC1, and SO). PCA combines these into heuristic measures, P0 and P1 for directing backtraces, and PD to advance the D-drive. The new ATPG program for all faults of benchmark circuits shows order of magnitude reduction in total backtracks and notable reduction in CPU time in comparison to the ATPG program with any single heuristic. For individual faults, backtracks often reduced to zero. Even redundant faults were identified by the new program with fewer backtracks.
Far-Field Decoupling of Two-Element Antenna Transceiving System by the Periodic Near-Field Resonators

In this letter, a hybrid wideband decoupling method based on far-field radiation regulation by employing the specially engineered periodic near-field resonators, which consist of split-ring resonator (SRR) arrays, is presented for the two collinear transceiving horn antennas with extremely large element spacing. Two E-plane-coupled antennas operating at X-band are arranged with center-to-center distance of 8 m (over 200λ). By allocating the SRR arrays in close proximity to each horn antenna, the radiation power in the specified horizontal directions pointing to each other could be significantly reduced without disturbing their radiation characteristics in the broadside thus leading to the conspicuous port isolation enhancement. It is validated that more than 25 dB mutual coupling level reduction is achieved over the frequency range of 8–11.5 GHz (∼35.9% fractional bandwidth) when the SRR arrays are integrated. Finally, a prototype was fabricated and measured. Corresponding measurement results are in good agreement with the simulated ones.
Research on Online Virtual Energy-Saving and Environment-Friendly Building Design and Implementation Based on VRML

In order to change the status quo of lacking holistic and intuitive research on building energy efficiency in China, an online virtual energy-saving and environment-friendly building system based on VRML was proposed. The two subsystems of virtual simulation technology, “virtual reality” and “energy consumption simulation,” were integrated and applied to the design research of building energy efficiency. On the basis of inheriting the advantages of the traditional way, the independent application mode of the two was changed. The application analysis was carried out using a real energy-saving demonstration project as the research object. The experimental results showed that the energy-saving rate of the enclosure structure of the three buildings was 35.742%, 30.408%, and 35.696%, respectively. It was concluded that the system provided a more systematic and intuitive method to the design and research of building energy efficiency.
Blockchain for Doping Control Applications in Sports: A Conceptual Approach

Doping is a well-known problem in competitive sports. Along the years, several cases have come to public, evidencing corrupt practices from within the sports environment. To guarantee fair play and prevent public health issues, anti-doping organizations and sports authorities are expected to cooperate in the fight against doping. To achieve this mission, doping-related data must be produced, stored, accessed, and shared in a secure, tamperproof, and privacy-preserving manner. This paper investigates the processes and tools established by the World Anti-Doping Agency for the global harmonization of doping control activities. From this investigation, it is possible to conclude that there is an inherent trust problem, in part due to a centralized data management paradigm and to the lack of fully digitalized processes. Therefore, this paper presents two main contributions: the concept of a multiorganizational decentralized data governance model and a blockchain-based design for one of the most sensitive data-sharing processes within the anti-doping ecosystem. Throughout this article, it is shown that the adoption of a permissioned blockchain can benefit the whole anti-doping community, creating more reliable processes for handling data, where privacy and security are enhanced.
Colza: Enabling Elastic In Situ Visualization for High-performance Computing Simulations

In situ analysis and visualization have grown increasingly popular for enabling direct access to data from high-performance computing (HPC) simulations. As a simulation progresses and interesting physical phenomena emerge, however, the data produced may become increasingly complex, and users may need to dynamically change the type and scale of in situ analysis tasks being carried out and consequently adapt the amount of resources allocated to such tasks. To date, none of the production in situ analysis frameworks offer such an elasticity feature, and for good reason: the assumption that the number of processes could vary during run time would force developers to rethink software and algorithms at every level of the in situ analysis stack. In this paper we present Colza, a data staging service with elastic in situ visualization capabilities. Colza relies on the widely used ParaView Catalyst in situ visualization framework and enables elasticity by replacing MPI with a custom collective communication library based on the Mochi suite of libraries. To the best of our knowledge, this work is the first to enable elastic in situ visualization capabilities for HPC applications on top of existing production analysis tools.
Friedelin Attenuates Neuronal Dysfunction and Memory Impairment by Inhibition of the Activated JNK/NF-κB Signalling Pathway in Scopolamine-Induced Mice Model of Neurodegeneration

Oxidative stress (OS) and c-Jun N-terminal kinase (JNK) are both key indicators implicated in neuro-inflammatory signalling pathways and their respective neurodegenerative diseases. Drugs targeting these factors can be considered as suitable candidates for treatment of neuronal dysfunction and memory impairment. The present study encompasses beneficial effects of a naturally occurring triterpenoid, friedelin, against scopolamine-induced oxidative stress and neurodegenerative pathologies in mice models. The treated animals were subjected to behavioural tests i.e., Y-maze and Morris water maze (MWM) for memory dysfunction. The underlying mechanism was determined via western blotting, antioxidant enzymes and lipid profile analyses. Molecular docking studies were carried out to predict the binding modes of friedelin in the binding pocket of p-JNK protein. The results reveal that scopolamine caused oxidative stress by (1) inhibiting catalase (CAT), peroxidase enzyme (POD), superoxide dismutase (SOD), and reduced glutathione enzyme (GSH); (2) the up-regulation of thiobarbituric acid reactive substances (TBARS) in mice brain; and (3) affecting the neuronal synapse (both pre- and post-synapse) followed by associated memory dysfunction. In contrast, friedelin administration not only abolished scopolamine-induced oxidative stress, glial cell activation, and neuro-inflammation but also inhibited p-JNK and NF-κB and their downstream signaling molecules. Moreover, friedelin administration improved neuronal synapse and reversed scopolamine-induced memory impairment accompanied by the inhibition of β-secretase enzyme (BACE-1) to halt amyloidogenic pathways of amyloid-β production. In summary, all of the results show that friedelin is a potent naturally isolated neuro-therapeutic agent to reverse scopolamine-induced neuropathology, which is characteristic of Alzheimer’s disease.
Preliminary Assessment of an FBG-Based Landing Gear Weight on Wheel System

Weight-on-Wheels (WoW) systems are aimed at indicating if the aircraft weight is loading onto the landing gear and its wheels, even partially. These systems are an integral part of the actuation system for safety-critical applications and shall provide reliable information on the actual operational status of the LG. That information reveals if the vehicle is in flight or on the ground. In this way, several kinds of accidents may be prevented, relating for instance, to the incorrect deployment of the landing gear, or even manoeuvres to a certain extent, therefore protecting the aircraft from dangerous damage. There are different architectures that have been proposed in the bibliography, some of them based on strain gauges deployed on the structure, or on proximity sensors installed on the wheels. Being this device and considered critical for safety, it is convenient to couple it with complementary measurements, recorded and processed by different sources. In general, it can be stated that such an intelligent sensor network may be seen as a fundamental support for proper landing gear deployment. The presented paper reports the results of a preliminary investigation performed by the authors to evaluate the possibility of deploying fibre optics on the landing gear structure as part of a WoW system to retrieve the required information. This choice would have a remarkable effect in terms of significant cabling reduction (a single array of sensing elements could be deployed over a single line), and cost abatement from both a manufacturing and operational point of view. There are many other benefits also when referring to an optical instead of a standard electrical sensor system. Due to its small size and ease of integration into different families of materials, it could be considered a system for monitoring the operating status of most actuators on board modern aircraft.
Identification of Candidate Biomarker and Drug Targets for Improving Endometrial Cancer Racial Disparities

Racial disparities in incidence and survival exist for many human cancers. Racial disparities are undoubtedly multifactorial and due in part to differences in socioeconomic factors, access to care, and comorbidities. Within the U.S., fundamental causes of health inequalities, including socio-economic factors, insurance status, access to healthcare and screening and treatment biases, are issues that contribute to cancer disparities. Yet even these epidemiologic differences do not fully account for survival disparities, as for nearly every stage, grade and histologic subtype, survival among Black women is significantly lower than their White counterparts. To address this, we sought to investigate the proteomic profiling molecular features of endometrial cancer in order to detect modifiable and targetable elements of endometrial cancer in different racial groups, which could be essential for treatment planning. The majority of proteins identified to be significantly altered among the racial groups and that can be regulated by existing drugs or investigational agents are enzymes that regulate metabolism and protein synthesis. These drugs have the potential to improve the worse outcomes of endometrial cancer patients based on race.
Trends and Topics in Research and Development Related to Transportation and Traffic Planning Technology

RTRI’s signalling and transport information division aims to contribute to enhanced safety, reliability, and ease of use through research and development in signalling systems, communication network technology, transportation planning and traffic operation, and condition monitoring technology of railway facilities. This paper outlines the trends in research and development aimed at providing supporting technology for transportation planning and rescheduling of train operations. It focuses largely on a number of topics related to activities and future plans for transport planning, attaching particular importance to railway transport, passenger flow analysis, quantitative evaluation of railway customer needs and economic evaluation of mass transport.
Distributed Energy System Feasibility and Supportive Energy Internet Technologies

The increasing demands of renewable energy lead to upgrading and iterating on current centralized grid system. Depends on the unique characteristics of green energies, such as photovoltaic power, wind power and so forth, the wide range of geographical allocation, power uncertainty and near to end-users has become the crucial consideration factors for next era energy system. Distributed energy system (DES) as a new emerging energy management method, it shows large numbers of similarities with renewable energy and it has been deemed as a potential reasonable way to solve the above issues. In order to illustrate whether DES have the ability to provide citizen with a sustainable, reliable and efficient grid system, this paper try to evaluate it from DES applications in different scopes and possible supportive energy internet technologies. Through discussing DES in regional and community scale, the physical limitations have been pointed out. Furthermore, micro-grid, blockchain technology and Virtual Power Plant (VPP) has been elected as potential methods to solve DES existing problems, such as data loads, inter communications between energy provider and consumer and energy trading mechanism. Since DES could not reach the optimal working status without other technologies support, how to integrate and combine different new emerging technologies into this energy system could be a further research direction. This significance of this paper is evaluating possibility of creating an autonomous, reliable, highly efficient and tradable energy system based on DES.
Stabilization and Walking Control for a Simple Passive Walker Using Computed Torque Method (RESEARCH NOTE)

Abstract The simple passive dynamic walker can walk down a shallow downhill slope with no external control or energy input. Nevertheless, the period-one gait stability is only possible over a very narrow range of slopes. Since the passive gaits are extremely sensitive to slope angles, it is important to use a control strategy in order to achieve a wide range of stable walking. The computed torque method is proposed here to produce stable period-one gait cycles for different slopes. In this present method, the unstable walking gait is stabilized by a stable period-one gait pattern on a small specific slope. The proposed approach is illustrated by the simplest passive walkers with point and curved feet. Simulation results reveal the usefulness of this control method for improvement in stability properties of the models.
A de novo missense mutation in the NC1 domain of type VII collagen leads to dystrophic epidermolysis bullosa

Dystrophic epidermolysis bullosa (DEB) is a genetic mechanobullous skin disorder that manifests at birth or in early infancy. The hallmarks of DEB are blister forma-tion, skin fragility, and nail dystrophy following minor trauma. The disorder results from mutations in the type VII collagen gene ( COL7A1) encoding the type VII collagen protein (C7). C7 is a major component of anchoring fibrils (AFs) [1], which is critical for attachment of the epidermis to the dermis. Dysfunction or loss-of-function of C7 leads to DEB. For instance, the complete loss of C7 causes the Hallopeau-Siemens type of DEB – the most severe phenotype. The inheritance pattern of mutated COL7A1 is either autosomal
Reliability and Ruggedness of 1200V SiC Planar Gate MOSFETs Fabricated in a High Volume CMOS Foundry

This paper presents the performance, reliability and ruggedness characterization of 1200V, 80mΩ rated SiC planar gate MOSFETs, fabricated in a high volume, 150mm silicon CMOS foundry. The devices showed a specific on-resistance of 5.1 mΩ. cm2 at room temperature, increasing to 7.5 mΩ. cm2 at 175 °C. Total switching losses were less than 300μJ (VDD = 800V, ID = 20A). The devices showed excellent gate oxide reliability with VTH shifts under 0.2V for extended HTGB stress testing at 175 °C for up to 5500 hours (VGS = 25V) and 2500 hours (VGS = -10V). Ruggedness performance such as unclamped inductive load switching and short circuit capability are also discussed.
An Enhanced DC-Bus Voltage-Control Loop for Single-Phase Grid-Connected DC/AC Converters

This paper presents a method to enhance the dc-bus voltage-control loop of a single-phase grid-connected dc/ac converter, which improves its responses in terms of oscillation on its dc-bus voltage as well as its output ac current. Conventionally, the double-frequency (2-f) ripple is reduced by using a large electrolyte capacitor, which increases the cost and size of the system. A state-of-the-art approach is to use a notch filter (NF) to block the 2-f ripple in the voltage-control loop. This can significantly reduce the capacitor size. The existing presentations of this method, however, do not integrate the internal dynamics of the NF into consideration. This paper proposes a new way of implementing the NF, which allows integration of its internal variables into the control loop. The resulted system exhibits enhanced transient responses at both the dc-bus voltage and the output ac current. The proposed method is analyzed in detail and its effectiveness is verified through simulations and experimental results.
Early Age Monitoring of High Cement Replacement Mixtures for Pavement

Decarbonization of concrete will require a combination of alternative binding materials and higher cement replacement rate with supplementary cementitious materials. Developing tools and methods that help engineers evaluate the properties of early age concrete pavement, such as setting time and strength gain, will be necessary to adopt new concrete mixes. Two concrete pavement test sections were constructed, a high early strength concrete mix with 25% (control) and 40% replacement of cement with fly ash (HVFAC), along with monitoring of the concrete’s setting time, saw-cut timing, and strength gain. A non-contact ultrasonic device was used to estimate setting time through measuring leaky Rayleigh wave energy transmission. The laboratory setting time of the control and HVFAC mix measured with the non-contact device was 5.5 h and 15 h, respectively, and agreed with measured isothermal calorimetry results. Further calorimeter tests showed that adding an accelerating admixture or replacing part of the cement with nano-limestone decreased the HVFAC setting time up to 4.4 h. The field setting time of the control mixture with the non-contact device measured 4.2 h, which was shorter than the laboratory estimate. Based only on the experience of construction personnel, saw-cutting for these mixtures was initiated too early and caused significant joint raveling, reinforcing the importance of in situ setting time measurement. The maturity method was successfully implemented with embedded wireless temperature sensors that rapidly and easily estimated the in-place compressive strength and improved opening time determination for concrete with high cement replacement levels, which are sensitive to the volume of supplementary cementitious materials, admixtures, and ambient conditions.
Syntactica

In § l des erwähnten Aufsatzes, in dem überflüssigerweise ,,die Struktur der Entzeitlichung der versprachlichten Welt" entdeckt wird, zitiert der Verfasser die mannigfachen Varianten der Glinzschen Auffassung vom Satz als Prägung eines in Zeitlichkeit eingebetteten Geschehens oder Seins. Diese bestechende Beschreibung des Satzes enthält aber noch immer nicht das Wesensmerkmal, das sowohl von Glinz als auch von Hartmann verkannt oder vielleicht sogar als unwichtig übergangen wurde, was man daraus schließen könnte, daß weder E. Winklers Satzdefinition noch meine an ihr vorgenommene Verbesserung mit einer Silbe erwähnt wurde. Das Grundwesen des Satzes liegt nicht, wie Glinz annimmt, in der zeitlichen Fixierung, sondern in der mit ihr verbundenen, sie aber überragenden und in gewissen Fällen sogar überdeckenden seinsartlichen (modalen) Bestimmung des Satzinhalts. Diese „Situierung" des Vorstellungskomplexes (= der reinen Materie) erfolgt entweder duroh die mit nicht weniger als fünf Funktionen beladene Richtform (= verbum finitum), durch die entsprechend getönte Nennoder Grundform des Verbs, d. i. durch den indikativischen oder konjunktivischen bzw. Imperativischen Infinitiv, oder durch den (energetischen) Setzungston einer anderen Wortklasse (,,Nacht." — „Hinaus! " — ,,O weh! "). Die modale Komponente steckt beim durchgeformten Satz im komplexen Funktionselement der Richtform und kann wortmäßig herausgehoben werden, wie dies besonders im Französischen häufig geschieht, so in der Rahmenformel est-ce que, die übrigens den besten Kommentar zur Seins-
Understanding Migrant Farmworkers’ Health and Well-Being during the Global COVID-19 Pandemic in Canada: Toward a Transnational Conceptualization of Employment Strain

During the COVID-19 pandemic, Canada imposed certain international travel bans and work-from-home orders, yet migrant farmworkers, declared essential to national food security, were exempt from such measures. In this context, farm worksites proved to be particularly prone to COVID-19 outbreaks. To apprehend this trend, we engaged an expanded and transnational employment strain framework that identified the employment demands and resources understood from a transnational perspective, as well as the immigration, labour, and public health policies and practices contributing to and/or buffering employment demands during and after the COVID-19 pandemic. We applied mixed methods to analyze administrative data, immigration, labour, and public health policy, as well as qualitative interviews with thirty migrant farmworkers employed in Ontario and Quebec. We concluded that the deleterious outcomes of the pandemic for this group were rooted in the deplorable pre-pandemic conditions they endured. Consequently, the band-aid solutions adopted by federal and provincial governments to address these conditions before and during the pandemic were limited in their efficacy because they failed to account for the transnational employment strains among precarious status workers labouring on temporary employer-tied work permits. Such findings underscore the need for transformative policies to better support health equity among migrant farmworkers in Canada.