Miracle-dz/UniFAR-FTUs huggingface dataset:
The Structure of Branching Onsets and Rising Diphthongs: Evidence from the Acquisition of French and Spanish

Abstract Consonant-glide-vowel (CGV) sequences are represented differently across languages. In some languages, the CG sequence is represented as a branching onset; in other languages, the GV sequence is represented as a rising diphthong. Given variable syllabification across languages, this study examines how young children represent CGV sequences. In particular, we evaluate Rose's (2000) proposal, based on French acquisition data, that CGV sequences are initially represented as rising diphthongs. To do this, we examined children's acquisition of CGV sequences in cross-sectional data from 14 French-speaking children (aged 1;10–2;10 years) and longitudinal data from five Spanish-speaking children (aged 1;3–3;0 years). Across several different measures (order of acquisition, style of acquisition, positional faithfulness, error patterns), children's production of rising diphthongs and branching onsets patterned similarly. The results suggest that at least for these children, CGV sequences are represented as branching onsets during the early stages of acquisition.
p 53 Mediates DNA Damaging Drug-induced Apoptosis through a Caspase-9-dependent Pathway in SH-SY 5 Y Neuroblastoma Cells 1

The signaling pathway for DNA damaging drugtriggered apoptosis was examined in a chemosensitive human neuroblastoma cell line, SH-SY5Y. Doxorubicin and etoposide induce rapid and extensive apoptosis in SH-SY5Y cells. After the drug treatment, p53 protein levels increase in the nucleus, leading to the induction of its transcription targets p21 and MDM2. Inactivation of p53, either by the human papillomavirus type 16 E6 protein or by a dominant-negative mutant p53 (R175H), completely protects SH-SY5Y cells from drug-triggered apoptosis. Cytochrome c and caspase-9 function downstream of p53 in mediating the drugtriggered apoptosis in SH-SY5Y cells. In drug-treated cells, cytochrome c is released, and caspase-9 becomes activated. Inactivation of p53 blocks cytochrome c release and caspase-9 activation. Furthermore, drug-induced cell death can be prevented by expression of a dominant-negative mutant of caspase-9. These findings define a molecular pathway for mediating DNA damaging drug-induced apoptosis in the human neuroblastoma SH-SY5Y cells and suggest that inactivation of essential components of this apoptotic pathway may confer drug resistance on neuroblastoma cells.
Fine‐needle aspiration cytology of solitary thyroid nodules

Fine‐needle aspiration cytology (FNAC) is a diagnostic tool used in the clinical workup of solitary thyroid nodules; however, differential cytologic diagnosis of these nodules often is challenging. With the goal of identifying cytologic findings that could improve predictions regarding the presence of neoplastic lesions, the authors performed a retrospective review of cases in which FNAC led to diagnoses of solitary cellular nodules or cellular microfollicular lesions at two university hospitals. FNAC smears associated with cases for which surgical specimens subsequently were obtained were reviewed. FNAC accurately detected follicular neoplasms in 76% of cases at one hospital and in 67% of cases at the other. In the current report, the cytologic findings made in these cases are reevaluated, and the potential diagnostic contribution of available clinical data is discussed. Cancer (Cancer Cytopathol) 2004. © 2004 American Cancer Society.
Realistic imitation of mosquito's proboscis -sharp and jagged needle and their cooperative inserting motion-

Aiming at the use in low-invasive medical treatments, this paper proposes a realistic imitation of mosquito's proboscis. A silicon needle is electrochemically etched, making the three-dimensionally sharp tip with finely smooth surface. The jagged shank shape is machined by DRIE. The combined needles comprising a central straight needle and two outer jagged needles are fabricated, imitating a labrum and two maxillas of the mosquito, respectively. The cooperative motion of the three needles imitating the mosquito's motion is realized by applying PZT actuators independently to all the needles. The effectiveness of inserting these needles cooperatively was experimentally confirmed.
Loss evaluation of AC filter inductor core on a PWM converter

This paper presents a core loss evaluation of AC filter inductor used on PWM converters. In order to increase the power density of the converters, high-frequency switching techniques have been applied. However, because of the limitation of cooling capability, reduction of volume of the passive components, especially the magnetic components, are limited. In order to overcome the problems, it is necessary to evaluate the loss of the magnetic components. However, conventional iron loss evaluation method, such as Steinmetz equation, cannot possible to evaluate the core loss, because those cannot take the dc-bias magnetizing condition into account. The authors have been proposed two kinds of iron loss evaluation method, the one is “a loss-map method” and the other is “an inductor loss analyzer (ILA)”. A distinctive feature of those methods is that one can know the iron loss during each switching period on the PWM inverters. Also, former one is suitable for accurate calculation of the core loss in designing process, and the later one is suitable for measuring the core loss on the practical system. By using those methods accurate design and evaluation of the iron loss can be made, and hence high power density design of the converters is realized. In this paper, firstly, a loss-map method which enables to calculate the iron loss of the ac/dc inductor in each switching period of the PWM inverter is briefly described. In the next section, an accurate measuring method of the iron loss of the ac filter inductor operating in a real PWM inverter is described. And it is proved that calculated and measured results coincide well. In the final section, iron loss characteristics of the ac filter inductor with various operating conditions of PWM inverter are discussed.
A Novel Compact Quad-Band Narrow Strip-Loaded Printed Monopole Antenna

A microstrip taper-fed compact printed monopole antenna that is suitable for mobile handset applications is presented. By embedding two narrow slits into the rectangular-shaped radiating patch, a triple-band operation that covers the applications such as GSM, DCS, and WLAN 2.4 GHz are realized within a 3:1 VSWR. To expand the bandwidth of the GSM band and to induce the PCS band to support quad-band applications without affecting the compactness of the proposed antenna, a novel method of loading a narrow back parasitic strip around the perimeter of the radiating patch is introduced. A prototype of the proposed antenna was successfully implemented, and good radiation performance is observed in all desired bands.
Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibodies recognizing the deamidated α subunit of the heterotrimeric GTPase Gq

Pasteurella multocida toxin (PMT) is a virulence factor responsible for the pathogenesis of some Pasteurellosis. PMT exerts its toxic effects through the activation of heterotrimeric GTPase (Gq, G12/13 and Gi)‐dependent pathways, by deamidating a glutamine residue in the α subunit of these GTPases. However, the enzymatic characteristics of PMT are yet to be analyzed in detail because the deamidation has only been observed in cell‐based assays. In the present study, we developed rat monoclonal antibodies, specifically recognizing the deamidated Gαq, to detect the actions of PMT by immunological techniques such as western blotting. Using the monoclonal antibodies, we found that the toxin deamidated Gαq only under reducing conditions. The C‐terminal region of PMT, C‐PMT, was more active than the full‐length PMT. The C3 domain possessing the enzyme core catalyzed the deamidation in vitro without any other domains. These results not only support previous observations on toxicity, but also provide insights into the enzymatic nature of PMT. In addition, we present several lines of evidence that Gα11, as well as Gαq, could be a substrate for PMT.
Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders

Introduction: The metabotropic glutamate receptor type 4 (mGluR4) plays a pivotal role in a plethora of therapeutic areas, as recently demonstrated in preclinical validation studies with several chemical classes of compounds in rodent models of central nervous system (CNS) and peripheral disorders. Activation of mGluR4 with orthosteric agonists, allosteric agonists or pure positive allosteric modulators (PAM) has been postulated to be of broad therapeutic use. Areas covered: The authors address past and current drug discovery efforts, insights and achievements in the field toward the identification of therapeutically promising and emerging class of mGluR4 activators, over the 2005 – 2011 period. Chemical structures, properties and in vivo pharmacological results discussed in the present review were retrieved from public literature including PubMed searches, Thomson Pharma and SciFinder databases searches, conferences, proceedings and posters. Expert opinion: Developing a subtype-selective, orally bioavailable brain penetrant mGluR4 orthosteric agonist remains challenging. Lack of subtype selectivity and low brain penetration has been a common limitation of the first generation of mGluR4 agonist and potentiators. However, significant progress has recently been made with the identification of several double- to single-digit nanomolar mGluR4 PAM having reasonable pharmacokinetic properties, oral bioavailability and brain penetration. The use of such compounds in research has led to advancement in understanding the central role of mGluR4 in multiple neurodegenerative and neuroinflammatory disorders, such as Parkinson's disease and multiple sclerosis. Our understanding of the potential application of mGluR4 as therapeutic target is expected to grow as these compounds advance into preclinical and clinical development.
Alkaline peroxide assisted wet air oxidation pretreatment approach to enhance enzymatic convertibility of rice husk

Pretreatment of rice husk by alkaline peroxide assisted wet air oxidation (APAWAO) approach was investigated with the aim to enhance the enzymatic convertibility of cellulose in pretreated rice husk. Rice husk was presoaked overnight in 1% (w/v) H2O2 solution (pH adjusted to 11.5 using NaOH) (equivalent to 16.67 g H2O2 and 3.63 g NaOH per 100 g dry, untreated rice husk) at room temperature, followed by wet air oxidation (WAO). APAWAO pretreatment resulted in solubilization of 67 wt % of hemicellulose and 88 wt % of lignin initially present in raw rice husk. Some amount of oligomeric glucose (˜8.3 g/L) was also observed in the APAWAO liquid fraction. APAWAO pretreatment resulted in 13‐fold increase in the amount of glucose that could be obtained from otherwise untreated rice husk. Up to 86 wt % of cellulose in the pretreated rice husk (solid fraction) could be converted into glucose within 24 hours, yielding over 21 g glucose per 100 g original rice husk. Scanning electron microscopy was performed to visualize changes in biomass structure following the APAWAO pretreatment. Enzymatic cellulose convertibility of the pretreated slurry at high dry matter loadings was also investigated. © 2011 American Institute of Chemical Engineers Biotechnol. Prog. , 2011
Computer-assisted Cobb angle measurement from posteroanterior radiographs by a curve fitting method

Incorrect determination of the top or end vertebrae of a scoliotic curve causes measurement errors when using the Cobb method. Such problems are due to subjectivity. This study was performed to minimize subjectivity by using a curve fitting method. A digitally scanned posteroanterior radiographic image was used for each patient. User-defined midpoints of the curvature, which indicate the midpoints of the vertebrae, were used to fit the polynomial equation. The locations of the top and end vertebrae were calculated using the first derivative of the fitted polynomial equation to obtain the analytical Cobb angle. The interobserver technical error of measurements was calculated as 1.06 degrees with a reliability coefficient of 1.00. The results indicate that 100% of the variations were not related to measurement error. Small angle variations show that subjectivity was minimized.
Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation

A blastocyst will implant only when the uterus becomes receptive. Following attachment, luminal epithelial cells undergo degeneration at the site of the blastocyst. Although many genes critical for uterine receptivity are primarily regulated by ovarian hormones, Kruppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is persistently expressed in epithelial cells independently of ovarian hormones. Loss of uterine Klf5 causes female infertility due to defective implantation. Cox2 is normally expressed in the luminal epithelium and stroma at the site of blastocyst attachment, but luminal epithelial COX2 expression is absent with loss of Klf5. This is associated with the retention of the epithelium around the implantation chamber with arrested embryonic growth. These results suggest that Klf5 is indispensable for normal implantation.
COGNITIVE STYLES AND HR COMPETENCIES IN IRANIAN UNIVERSITIES Mir

The following article aims to identify the effects of Jung’s cognitive styles on Human resource (HR) competency levels in order to predict the level of competencies among those who are going to apply for a position and those who are seeking promotion. The data was collected from 102 HR administrators and professionals of 5 top ranked Iranian universities. The universities were chosen from the 2010 Quacquarelli Symonds (QS) World University Rankings. The questionnaire of this research includes two groups of tests, including Competencies' assessment tests and Jung’s cognitive style tests. The findings of this study show that there is a significant correlation between Joung’s cognitive styles and HR competency levels. The results of this study may be applicable as a hint in the top ranked universities for employing applicants with the best qualifications specially those who have no or not enough job experience. © 2014 AESS Publications. All Rights Reserved.
Design and Implementation of the HB1 Hyperbase Management System

SUMMARY Hypermedia systems manage interconnected information residing within a potentially wide range of data types, including text, graphics, animations, and digitized sound and images. Effective database support for hypermedia-basedcomputing environments is essential. In order to be effective, this support must provide a variety of capabilities that are not offered by the current generation of database management systems. We report on a prototypic system called HB1 that has been designed to meet the storage needs of advanced hypermedia system architectures. HB1 is referred to as a hyperbase management system (HBMS) because it stores and manipulates information and the connectivity data that link information together to form hypermedia. HB1 is composed of three subsystems: the Object Manager (OM), Association Set Manager (ASM), and Storage Manager (SM). OM and ASM are both server processes accessible to distributed client processes via IPC interfaces. OM is an object server. ASM manages structural data applicable to the objects within OM’s repository that are involved in hypermedia connections. Physical storage is managed by SM which, in this implementation, is a semantic network database management system. HB1 instantiates a conceptual model of hypermedia that is distinctly computational, has a strong notion of anchor and link, and abstracts information, behavior, and structure from hypermedia. It has been used as a back-end for an open, object-based hypermedia system that implements distributed, inter-application linking. HB1 is proving to be an effective vehicle for research on HBMS organization.
Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner

Environmental manipulations can enhance neuroplasticity in the brain, with enrichment‐induced cognitive improvements being linked to increased expression of growth factors, such as neurotrophins, and enhanced hippocampal neurogenesis. There is, however, a great deal of variation in environmental enrichment protocols used in the literature, making it difficult to assess the role of particular aspects of enrichment upon memory and the underlying associated mechanisms. This study sought to evaluate the efficacy of environmental enrichment, in the absence of exercise, as a cognitive enhancer and assess the role of Nerve Growth Factor (NGF), neurogenesis and synaptogenesis in this process. We report that rats housed in an enriched environment for 3 and 6 weeks (wk) displayed improved recognition memory, while rats enriched for 6 wk also displayed improved spatial and working memory. Neurochemical analyses revealed significant increases in NGF concentration and subgranular progenitor cell survival (as measured by BrdU+ nuclei) in the dentate gyrus of rats enriched for 6 wk, suggesting that these cellular changes may mediate the enrichment‐induced memory improvements. Further analysis revealed a significant positive correlation between recognition task performance and BrdU+ nuclei. In addition, rats enriched for 6 wk showed a significant increase in expression of synaptophysin and synapsin I in the dentate gyrus, indicating that environmental enrichment can increase synaptogenesis. These data indicate a time‐dependent cognitive‐enhancing effect of environmental enrichment that is independent of physical activity. These data also support a role for increased concentration of NGF in dentate gyrus, synaptogenesis, and neurogenesis in mediating this effect. © 2013 Wiley Periodicals, Inc.
Topical Application of Arnica and Mucopolysaccharide Polysulfate Attenuates Periorbital Edema and Ecchymosis in Open Rhinoplasty: A Randomized Controlled Clinical Study

Background: The purpose of this study was to investigate the effects of local arnica and mucopolysaccharide polysulfate treatment on the regression of postoperative edema and ecchymosis in patients who have undergone open technique rhinoplasty. Method: One hundred eight patients were included in the study. Participants were randomized into three groups, all of whom had undergone rhinoplasty. Group 1 (n = 36) received postoperative arnica cream treatment, and group 2 (n = 36) received postoperative mucopolysaccharide polysulfate cream treatment. Group 3 (n = 36, control group) consisted of patients who received no postoperative local treatments. Patients were evaluated for 24 hours on days 2, 5, 7, and 10 after the operation. For the evaluation of postoperative edema and ecchymosis, a scale ranging from 0 to 4 was used, and the groups were compared. Results: In groups 1 and 2, postoperative ecchymosis was significantly less than in the control group during postoperative days 1, 5, and 7 (p < 0.005). The regression of the edema was also more rapid in groups 1 and 2 than in the control group during evaluations on postoperative days 1, 5, and 7 (p < 0.005). Neither edema nor ecchymosis was significantly different between groups 1 and 2 (p > 0.005). Conclusions: The authors’ results suggest that a rapid regression of edema and ecchymosis may be achieved by local treatments of arnica and mucopolysaccharide polysulfate cream. In addition, there are no significant differences between these two treatment regimens. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
P21 activated kinases

The p21 activated kinases (Paks) are well known effector proteins for the Rho GTPases Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first family consists of Paks 1, 2, and 3, and the second consists of Paks 4, 5, and 6. While some of the Paks are ubiquitously expressed, others have more restrictive tissue specificity. All of them are found in the nervous system. Studies using cell culture, transgenic mice, and knockout mice, have revealed important roles for the Paks in cytoskeletal organization and in many aspects of cell growth and development. This review discusses the basic structures of the Paks, and their roles in cell growth, development, and in cancer.
Short-term prognosis after emergency department diagnosis of TIA.

CONTEXT Management of patients with acute transient ischemic attack (TIA) varies widely, with some institutions admitting all patients and others proceeding with outpatient evaluations. Defining the short-term prognosis and risk factors for stroke after TIA may provide guidance in determining which patients need rapid evaluation. OBJECTIVE To determine the short-term risk of stroke and other adverse events after emergency department (ED) diagnosis of TIA. DESIGN AND SETTING Cohort study conducted from March 1997 through February 1998 in 16 hospitals in a health maintenance organization in northern California. Patients A total of 1707 patients (mean age, 72 years) identified by ED physicians as having presented with TIA. MAIN OUTCOME MEASURES Risk of stroke during the 90 days after index TIA; other events, including death, recurrent TIA, and hospitalization for cardiovascular events. RESULTS During the 90 days after index TIA, 180 patients (10.5%) returned to the ED with a stroke, 91 of which occurred in the first 2 days. Five factors were independently associated with stroke: age greater than 60 years (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-2.7; P=.01), diabetes mellitus (OR, 2.0; 95% CI, 1.4-2.9; P<.001), symptom duration longer than 10 minutes (OR, 2.3; 95% CI, 1.3-4.2; P=.005), weakness (OR, 1.9; 95% CI, 1.4-2.6; P<.001), and speech impairment (OR, 1.5; 95% CI, 1.1-2.1; P=.01). Stroke or other adverse events occurred in 428 patients (25.1%) in the 90 days after the TIA and included 44 hospitalizations for cardiovascular events (2.6%), 45 deaths (2.6%), and 216 recurrent TIAs (12.7%). CONCLUSIONS Our results indicate that the short-term risk of stroke and other adverse events among patients who present to an ED with a TIA is substantial. Characteristics of the patient and the TIA may be useful for identifying patients who may benefit from expeditious evaluation and treatment.