Miracle-dz/UniFAR-FTUs huggingface dataset:
Quelques problèmes de géométrie énumérative, de matrices aléatoires, d'intégrabilité, étudiés via la géométrie des surfaces de Riemann

La geometrie complexe est un outil puissant pour etudier les systemes integrables classiques, la physique statistique sur reseau aleatoire, les problemes de matrices aleatoires, la theorie topologique des cordes, …Tous ces problemes ont en commun la presence de relations, appelees equations de boucle ou contraintes de Virasoro. Dans le cas le plus simple, leur solution complete a ete trouvee recemment, et se formule naturellement en termes de geometrie differentielle sur une surface de Riemann : la "courbe spectrale", qui depend du probleme. Cette these est une contribution au developpement de ces techniques et de leurs applications.Pour commencer, nous abordons les questions de developpement asymptotique a tous les ordres lorsque N tend vers l’infini, des integrales N-dimensionnelles venant de la theorie des matrices aleatoires de taille N par N, ou plus generalement des gaz de Coulomb. Nous expliquons comment etablir, dans les modeles de matrice beta et dans un regime a une coupure, le developpement asymptotique a tous les ordres en puissances de N. Nous appliquons ces resultats a l'etude des grandes deviations du maximum des valeurs propres dans les modeles beta, et en deduisons de facon heuristique des informations sur l'asymptotique a tous les ordres de la loi de Tracy-Widom beta, pour tout beta positif. Ensuite, nous examinons le lien entre integrabilite et equations de boucle. En corolaire, nous pouvons demontrer l'heuristique precedente concernant l'asymptotique de la loi de Tracy-Widom pour les matrices hermitiennes.Nous terminons avec la resolution de problemes combinatoires en toute topologie. En theorie topologique des cordes, une conjecture de Bouchard, Klemm, Marino et Pasquetti affirme que des series generatrices bien choisies d'invariants de Gromov-Witten dans les espaces de Calabi-Yau toriques, sont solution d'equations de boucle. Nous l'avons demontre dans le cas le plus simple, ou ces invariants coincident avec les nombres de Hurwitz simples. Nous expliquons les progres recents vers la conjecture generale, en relation avec nos travaux. En physique statistique sur reseau aleatoire, nous avons resolu le modele O(n) trivalent sur reseau aleatoire introduit par Kostov, et expliquons la demarche a suivre pour resoudre des modeles plus generaux.Tous ces travaux soulignent l'importance de certaines "integrales de matrices generalisees" pour les applications futures. Nous indiquons quelques elements appelant a une theorie generale, encore basee sur des "equations de boucles", pour les calculer
invited review Structure and function of aquaporin water channels

Structure and function of aquaporin Am. J. Physiol. Renal Physiol. 278: F13–F28, 2000. —The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size , 30 kDa) that are expressed at plasma membranes in many cells types involved in ﬂuid transport. This review is focused on the molecular structure and function of mammalian aquaporins. Basic features of aquaporin structure have been deﬁned using mutagenesis, epitope tagging, and spectroscopic and freeze-fracture electron microscopy methods. Aquaporins appear to assemble in mem- branes as homotetramers in which each monomer, consisting of six membrane-spanning a -helical domains with cytoplasmically oriented amino and carboxy termini, contains a distinct water pore. Medium- resolution structural analysis by electron cryocrystallography indicated that the six tilted helical segments form a barrel surrounding a central pore-like region that contains additional protein density. Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9). Evidence for possible movement of ions and carbon dioxide through the aquaporins is reviewed here, as well as evidence for direct regulation of aquaporin function by posttranslational modiﬁcation such as phosphorylation. Important unresolved issues in- clude deﬁnition of the molecular pathway through which water and solutes move, the nature of monomer-monomer interactions, and the physiological signiﬁcance of aquaporin-mediated solute movement. Recent results from knockout mice implicating multiple physiological roles of aquaporins suggest that the aquaporins may be suitable targets for drug discovery by structure-based and/or high-throughput screening strategies.
Heteromeric TRPC1/TRPC4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration

Canonical transient receptor channels (TRPCs) are receptor-operated cation channels which are activated in response to phospholipase C signaling. Although TRPC1 is ubiquitously expressed in the brain, TRPC4 expression is the most restrictive, with the highest expression level limited to the lateral septum. The subunit composition of neuronal TRPC channels remains uncertain because of conflicting data from recombinant expression systems. Here we report that the large depolarizing plateau potential that underlies the epileptiform burst firing induced by metabotropic glutamate receptor agonists in lateral septal neurons was completely abolished in TRPC1/4 double knockout mice, and was abolished in 74% of lateral septal neurons in TRPC1 knockout mice. Furthermore, neuronal cell death in the lateral septum and the CA1 region of hippocampus after pilocarpine-induced severe seizures was significantly ameliorated in TRPC1/4 double knockout mice. Our data suggest that both TRPC1 and TRPC4 are essential for an intrinsic membrane conductance mediating the plateau potential in lateral septal neurons, possibly as heteromeric channels. Moreover, excitotoxic neuronal cell death, an underlying process for many neurological diseases, is not merely mediated by ionotropic glutamate receptors, but also by heteromeric TRPC channels activated by metabotropic glutamate receptors. TRPC channels could be an unsuspected but critical molecular target for clinical intervention for excitotoxicity.
Implementation of Deep Learning based Rendering De-Noising Accelerator

Background/Objectives : In this paper, we implemented the neural network of learning based filtering algorithm, which eliminates noise generated by ray-tracing, through Verilog HDL. Methods/Statistical analysis : The neurons used in the learning based filtering algorithm are divided into five stages: IDLE, SIGN, MUL, SUM, and ACT. Each stage is processed in one cycle through the FSM(Finite State Machine). These neurons were organized into a number of layers. The operation used fixed point. Findings : The neural network has a large amount of computation, but since the computation is simple, it can be processed quickly by hardware implementation. It has a hidden layer (10 neurons with 36 inputs), an output layer (6 neurons with 10 inputs), each layer has 5 stages, so you can get the filtering parameters after 10 cycles. Improvements/Applications : Verilog HDL can be synthesized and downloaded to the FPGA to operate up to 185MHz.
International Journal of Innovative Technology and Exploring Engineering (IJITEE)

648 Published By: Blue Eyes Intelligence Engineering and Sciences Publication Retrieval Number: I7647079920/2020©BEIESP DOI: 10.35940/ijitee.I7647. 079920  Abstract: Two-dimensional photonic crystals play important role in practical photonic devices. In this study, Hamiltonian method is used to determine the evolution equations for the fields. This method allows us to determine the polariton modes inside a periodically structured medium. For a two-dimensional photonic crystal, the Hamiltonian for electromagnetic field interaction with structured medium is constructed and the evolution equations for fields are determined from Hamilton’s equations of motion. The polariton modes are found from the canonical form of the Hamiltonian.
ON VARIABLE METRIC METHODS OF MINIMIZATION

Abstract : Two basic approaches to the generation of conjugate directions are considered for the problem of unconstrained minimization of a quadratic function. Using the principle of choosing a step direction orthogonal to the previous gradient changes, a projected gradient algorithm and a class of variable metric algorithms are derived. Three variants of the class are developed into algorithms, one of which is the Fletcher-Powell-Davidon scheme. Numerical results indicate the merits of the new algorithms compared to several now in use, for a variety of nonquadratic problems.
University of Birmingham The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NF kappa B Feedback

Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NF k B. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease.
Aggregate & Heterogeneous Sectoral Effects of FDI in Egypt

This paper investigates the sectoral impacts of FDI on growth in Egypt between 1990 and 2007 based upon a unique data set. It highlights the aggregation bias inherent in many empirical studies that focus solely on the economy-wide effects of foreign investment. Aggregate inflows of FDI are shown to be detrimental to the country’s economic growth performance, possibly as a result of the ‘crowding-out’ of more productive domestic investment. Some positive sector-specific effects however, are found for investment in Manufacturing & Petroleum, which also has beneficial spillovers into other sectors. FDI in the Finance & Retail and Telecommunications & Information Technology sectors are found to generate significantly negative growth effects while those in Services and Tourism are negative but generally insignificant. These findings suggest that ‘market-seeking’ FDI in certain sectors has conspicuous ‘crowding-out’ effects, possibly owing to insufficient domestic absorptive capacity. The results of this study further demonstrate the importance of potential sectoral heterogeneity of own sector and inter-sectoral economic growth effects of FDI. It therefore highlights the critical need for policy makers to take a more disaggregated sectoral-level evaluation of the benefits of foreign investment, particularly in developing economies such as Egypt.
Running Head: EFFECTIVENESS OF CONFLICT MANAGEMENT TRAINING Assessing the Effectiveness of Conflict Management Training in a Health Sector Organisation: Evidence from Subjective and Objective Indicators*

The study assessed the effectiveness of an intervention for handling interpersonal conflicts at work. In contrast to the mainstream approach in the healthcare industry, which focuses on developing formal systems of conflict resolution, our intervention consisted of enhancing healthcare workers’ conflict management skills through training. A pre- and post-test non-equivalent comparison group design was used (intervention group = 258 workers; comparison group = 243 workers). Participants perceived that the training was successful in reducing the number and intensity of conflicts with co-workers, patients and patients’ relatives. Moreover, organisational indicators calculated on the basis of data obtained from Human Resources (HR) records show that the intervention was effective, insofar as the number of requests for third-party interventions to mediate conflicts at work, the number of patients’ complaints, and the level of absenteeism all decreased for trained workers, whereas workers from the comparison group exhibited no corresponding changes over time. In light of these results, this paper discusses the design of conflict management measures which could help improve both employees’ well-being and organisational productivity.
EEG distributed source imaging with a realistic finite-element head model

We have investigated EEG distributed source imaging with a realistic finite-element (FE) head model. The performance of different FE imaging methods is evaluated and compared in 2D and 3D simulation studies. The results demonstrate the feasibility of EEG distributed source imaging with FE head models using FE inverse methods. We also show that incorporating prior knowledge of sources significantly improves the inverse solutions.
The Nexus between Bank Foreign Expansion and Efficiency: The Moderating Effects of Host Country Regulation and Competition

ABSTRACT Does Chinese bank efficiency benefit or suffer from foreign expansion? To investigate the causal relationship between banks foreign expansion and efficiency, we analyze 431 overseas branches of Chinese banks from 2007 to 2020. After decomposing the efficiency, we find strong, consistent evidence that such foreign expansion reduces cost efficiency due to the agency problem, while improving profit efficiency to retain the long-term bank–client relationship. Furthermore, to examine moderating effects, we consider regulations and competition among host countries. Ultimately, stringent regulations and less competition are found to be key factors impacting the loss and gain of cost and profit efficiency.
Associations between the TNMD rs4828038 and ACE2 rs879922 polymorphisms and preeclampsia susceptibility: a case-control study

Abstract A case-control study was designed to investigate the association between the angiotensin converting enzyme 2 (ACE2) rs879922, glucose-6-phosphate dehydrogenase (G6PD) rs1050828, and tenomodulin (TNMD) rs4828038 single nucleotide polymorphisms (SNPs), and preeclampsia. A total of 356 Han Chinese pregnant women (170 controls and 186 cases) were recruited into the study. ACE2 rs879922, G6PD rs1050828, and TNMD rs4828038 were tested by the targeted next-generation sequencing technology and the data were analyzed using SPSS version 18. Genotyping of results revealed that patients with the CC/CT genotype in SNP rs4828038 or CC/CG genotype in SNP rs879922 had a significantly decreased susceptibility to late-onset preeclampsia (CC/CT versus TT: OR = 0.543, 95% CI = 0.378 to 0.779, p = .001; CC/CG versus GG: OR = 0.510, 95% CI = 0.038 to 0.860, p = .012). Our study found that the polymorphisms TNMD rs4828038 and ACE2 rs879922 might be associated with late-onset preeclampsia. IMPACT STATEMENT What is already known on this subject? Preeclampsia is associated with multiple SNPs, and ACE2 rs879922, G6PD rs1050828, and TNMD rs4828038 are related to essential hypertension and glucose and lipid metabolism disorders. Essential hypertension, diabetes, and dyslipidemia are risks for preeclampsia. The associations between those three SNPs and preeclampsia have not been reported. What do the results of this study add? The polymorphisms of TNMD rs4828038 and ACE2 rs879922 might be associated with the risk of late-onset preeclampsia. There was no relationship between SNP rs1050828 and preeclampsia. What are the implications of these findings for clinical practice and/or further research? TNMD rs4828038 and ACE2 rs879922 might be target sites for genetic diagnosis and therapy, and the levels of mRNA and protein in pregnant women with preeclampsia should be further tested.
A Stellar Spectral Flux Library: 1150–25000 Å

A stellar spectral flux library of wide spectral coverage and an example of its application are presented. The new library consists of 131 flux‐calibrated spectra, encompassing all normal spectral types and luminosity classes at solar abundance, and metal‐weak and metal‐rich F–K dwarf and G–K giant components. Each library spectrum was formed by combining data from several sources overlapping in wavelength coverage. The SIMBAD database, measured colors, and line strengths were used to check that each input component has closely similar stellar type. The library has complete spectral coverage from 1150 to 10620 Å for all components and to 25000 Å for about half of them, mainly later types of solar abundance. Missing spectral coverage in the infrared currently consists of a smooth energy distribution formed from standard colors for the relevant types. The library is designed to permit inclusion of additional digital spectra, particularly of non–solar abundance stars in the infrared, as they become available. The library spectra are each given as Fλ versus λ, from 1150 to 25000 Å in steps of 5 Å. A program to combine the library spectra in the ratios appropriate to a selected isochrone is described and an example of a spectral component signature of a composite population of solar age and metallicity is illustrated. The library spectra and associated tables are available as text files by remote electronic access.
Metacercariae in the brain of Erythrinus cf. erythrinus (Characiformes: Erythrinidae) from Iguazú National Park (Argentina): do they belong to Dolichorchis lacombeensis (Digenea, Diplostomidae)?

Abstract In Argentina, the family Diplostomidae is composed of eight genera: Austrodiplostomum Szidat & Nani; Diplostomum von Nordmann; Dolichorchis Dubois; Hysteromorpha Lutz; Neodiplostomum Railliet; Posthodiplostomum Dubois; Sphincterodiplostomum Dubois; and Tylodelphys Diesing. During a parasitological survey of fishes from the Iguazú National Park we detected diplostomid metacercariae in the brain of Erythrinus cf. erythrinus. Fish were caught using crab traps, transported alive to the field laboratory, cold-anaesthetized and euthanized by cervical dissection. Some metacercariae were heat-killed in water and fixed in 10% formalin and others were preserved in alcohol 96% for DNA extraction. They were sequenced for the partial segment of the 28S rDNA, internal transcribed spacer (ITS) rDNA and cytochrome c oxidase subunit I (COI) mtDNA genes. Phylogenetic reconstruction was carried out using Bayesian inference and the proportion (p) of absolute nucleotide sites (p-distance) was obtained. In the 28S rDNA tree, the metacercaria sequenced grouped as Dolichorchis sp. The COI mtDNA p-distance between the metacercariae with Dolichorchis lacombeensis was 0.01. There is a small number of ITS sequences for the Diplostomidae family deposited in the GenBank. The oral sucker, ventral sucker, holdfast organ and the distance between oral and ventral suckers are larger in the adult compared with the metacercariae. Additionally, hind-body length and width are larger in the adult due to the development of the genital complex. Further studies using an integrative approach will help confirm the affiliation of other species to the genus Dolichorchis.
Effects of weight gaining to lower limb joint moments: a gender-specific sit-to-stand analysis

Abstract The prevalence of obesity, a worldwide health problem, is increasing. Obesity or overweight has significant effects, especially on lower limb biomechanics. Previous studies have investigated the biomechanical effects of weight gain on the knee and hip joints. These studies have been conducted on different individuals with normal weight and overweight. However, no investigation has been carried out between women and men in terms of weight gain. Females usually gain weight in the gluteal-femoral region, whereas males gain weight in the abdominal region. Due to this difference, it is thought that the effects of weight gain should be examined in a gender-specific manner. In this study, a link-segment model of the lower limb was created. Then the sit-to-stand movement was simulated according to female and male-specific weight gain scenarios. According to these results, weight gain in the abdominal region (men-specific) increases the ankle and knee joint moments more than weight gain in the gluteal-femoral region (women-specific). In obese scenarios for males and females, while the ankle and knee joint moment increases, the hip joint moment decreases. These results would be beneficial for considering biomechanical differences caused by gender-specific weight gain in rehabilitation processes and orthotic and prosthetic designs.
Estimating the dynamic lifetime of transient context in near real-time for cost-efficient adaptive caching

Context-awareness in Internet of Things (IoT) applications has significant impact on how IoT data can be processed, stored if needed, reused, and repurposed across multiple IoT applications. Emerging Context Management Platforms (CMP) mediate between context providers and context consumers in order to unify access to context and, provide interoperability that allows cross-domain context querying. This paper proposes an approach to adaptive context caching which enables CMPs to serve context queries from multiple IoT applications. It presents the transient nature of context which is a unique challenge when caching context that requires regular refreshing. The paper proposes two adaptive refreshing strategies based on online-estimated lifetimes (i.e., how long before data is estimated to have changed and refreshing is needed) - reactive and full-coverage. They are evaluated by developing mathematical models and simulations. We further assess the impact of different parameters on context cache performance. The results demonstrate the efficiency of adaptive context caching to minimize operational costs whilst preserving good enough refresh rate and compliance with Service Level Agreements.