Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Reinforcement Learning Collision Avoidance Algorithm for USVs Based on Maneuvering Characteristics and COLREGs

Autonomous collision avoidance technology provides an intelligent method for unmanned surface vehicles’ (USVs) safe and efficient navigation. In this paper, the USV collision avoidance problem under the constraint of the international regulations for preventing collisions at sea (COLREGs) was studied. Here, a reinforcement learning collision avoidance (RLCA) algorithm is proposed that complies with USV maneuverability. Notably, the reinforcement learning agent does not require any prior knowledge about USV collision avoidance from humans to learn collision avoidance motions well. The double-DQN method was used to reduce the overestimation of the action-value function. A dueling network architecture was adopted to clearly distinguish the difference between a great state and an excellent action. Aiming at the problem of agent exploration, a method based on the characteristics of USV collision avoidance, the category-based exploration method, can improve the exploration ability of the USV. Because a large number of turning behaviors in the early steps may affect the training, a method to discard some of the transitions was designed, which can improve the effectiveness of the algorithm. A finite Markov decision process (MDP) that conforms to the USVs’ maneuverability and COLREGs was used for the agent training. The RLCA algorithm was tested in a marine simulation environment in many different USV encounters, which showed a higher average reward. The RLCA algorithm bridged the divide between USV navigation status information and collision avoidance behavior, resulting in successfully planning a safe and economical path to the terminal.
Press-Coated Aceclofenac Tablets for Pulsatile Drug Delivery: Formulation and In Vitro Evaluations

The symptoms of some diseases show circadian rhythms, such as the morning stiffness associated with pain at the time of awakening in rheumatoid arthritis. Therapy for such diseases doesn’t require immediate release or sustained release of medicament. In such therapies, pulsatile drug release is more suitable with a programmed drug release. The purpose of this research was to formulate press-coated aceclofenac tablets for pulsatile drug delivery with a distinct delay time of no drug release and release of the drug when it is more likely desired (i.e., after 5 to 6 h). Immediate release core tablets having aceclofenac were formulated. Three formulations, F1, F2, and F3, were prepared with variable concentrations of sodium croscarmellose. Pre- and post-compression tests were performed on the core tablets. The selection criteria included the lowest disintegration time as a requirement of pulsatile drug delivery with an immediate release core and a delayed release coat. The disintegration times of F1, F2, and F3 were 120 s, 60 s, and 15 s, respectively. Therefore, the F3 formulation was selected as the core tablet formulation because it had the shortest disintegration time (15 s). The core tablets were press-coated using different polymers, such as HPMC K100M, Eudragit L100, HEC, and HPMC E5. The polymers were used in the coatings to hinder the release of the core for the desired time. 36 formulations of polymer were prepared: A1 to A10 had HPMC K100M and Avicel PH102; formulations B1 to B6 had HPMC K100M, Eudragit L100, and Avicel PH102; formulations C1 to C7 had HPMC K100M and hydroxyethyl cellulose; formulations D1 to D7 had HPMC K100M and HPMC E5; and formulations E1 to E6 had changed the coating weight of the formulation used for D6 (having HPMC K100M and HPMC E5 in the ratio of 12.5% to 87.5%). Evaluations of the press-coated tablets were carried out through thickness, hardness, weight variation, friability, and in vitro dissolution tests. These parameters concluded that the formulation of E6, having HPMC K100M and HPMC E5 in the ratio of 12.5% to 87.5% at 600 mg weight, was the most optimum formulation as it showed 3.5% drug release after 4 h, 21.4% drug release after 5 h, and 99.27% drug release after 6 h.
Heterogeneous Federated CubeSat System: problems, constraints and capabilities

—Different arguments were being presented in the last decade about CubeSats and their applications. Some of them address wireless communication (5G and 6G technologies) trying to achieve better characteristics as coverage and connectivity. Some arrived with terms as IoST (Internet of Space Things), Internet of Satellites (IoSat), DSS (Distributed Space Systems), and FSS (Federated Satellite Systems). All of them aim to use Small/NanoSatellites as constella- tions/swarms is to provide speciﬁc services, share unused resources, and evolve the concept of satellites-as-a-service (SaS). This paper aims to emophasize performance attributes of such cyber-physical systems, model their inherent operational constraints and at the very end, evaluate the quality of service in terms of ﬁgures of merit for the entering/leaving of new heterogeneous constituent systems, a.k. a satellites, to the con- stellation. This ”whitepaper”-styled work focuses on presenting the deﬁnitions of this heterogeneous constellation problem, aims at its main capabilities and constraints, and proposes modeling approaches for this system representation and evaluation.
Research on Carrier Disposition PWM Control Method for Three-level NPC Inverter

The output voltage equations of the three-level NPC inverter with carrier phase disposition and opposition dispo-sition PWM control methods have been derived respectively by means of dual Fourier transforms.The harmonic character-istics of the output voltages are compared objectively.An experimental device based on FPGA and embedded computer is constructed in laboratory.The experimental results verify the exactness of theoretics analysis.
Plasmid-Mediated Quinolone Resistance (PMQR) in Two Clinical Strains of Salmonella enterica Serovar Corvallis

Non-typhoid serovars of Salmonella enterica are one of the main causes of bacterial food-borne infections worldwide. For the treatment of severe cases of salmonellosis in adults, fluoroquinolones are amongst the drugs of choice. They are categorized by the World Health Organization (WHO) as “critically important with highest priority in human medicine”. In the present study, two clinical S. enterica serovar Corvallis isolates (HUA 5/18 and HUA 6/18) from a Spanish hospital, selected on the basis of fluoroquinolone resistance, were characterized. The MICs of ciprofloxacin, determined by E-test, were 0.5 and 0.75 µg/mL for HUA 5/18 and HUA 6/18, respectively, and both were also resistant to pefloxacin but susceptible to nalidixic acid. Whole genome sequencing (WGS) of the isolates was performed with Illumina platform, and different bioinformatics tools were used for sequence analysis. The two isolates belonged to ST1541, and had the Thr57Ser substitution in the ParC protein which is also found in ciprofloxacin susceptible isolates. However, they harbored identical ColE plasmids of 10 kb carrying the qnrS1 gene. In these plasmids, the gene was flanked by defective versions of IS2-like and ISKra4-like insertion sequences. HUA 5/18 and HUA 6/18 were also phenotypically resistant to streptomycin, sulfonamides and tetracycline, with the responsible genes: strA, strB, sul2 and tet(A) genes, being located on a IncQ1 plasmid. ColE plasmids with the qnrS1 gene are widely spread among multiple serovars of S. enterica from different samples and countries. These mobilizable plasmids are playing an important role in the worldwide spread of qnrS1. Thus, their detection in hospitals is a cause of concern which deserves further attention.
Study of VSC-HVDC connected to passive network discrete model and its control strategies

The discrete mathematical model VSC-HVDC system in dq reference frame is derived and discrete controllers are designed for transmitting power to passive network via VSC-HVDC system. According to the discretely steady mathematical model of the converter, a constant DC voltage and constant reactive power controller is used in the rectifier-side; a constant AC voltage controller is used in the inverter-side to control the AC bus voltage. The VSC-HVDC connected to passive network digital simulation model is set up by the electromagnetic transient simulation software PACAD/EMTDC. Simulation results, in the case of various engineering , verify that the designed discrete model is correct and the control strategy is effective.
Cardiovascular Care of Turner Syndrome Women in Germany: Where Do We Stand?—Results from an Online Patient Survey

Background: This study aimed to investigate whether the cardiovascular care of Turner Syndrome (TS) women in Germany is in accordance with the latest clinical practice guidelines established by the 2016 Cincinnati international TS meeting. Methods: An anonymous online questionnaire was created to ask TS subjects about existing cardiovascular conditions and cardiovascular care received. Depending on cardiovascular morbidity and type of medical care received, the fulfillment of the latest clinical practice guidelines for the care of TS women was assessed. Results: 120 TS patients were included in this study. The mean age of TS subjects was 36.79 years. Only 80% of subjects received annual blood pressure measurements within the TS cohort, and only 60% received cardiac imaging according to international clinical practice guidelines. More than 55% of TS women did not feel well informed about TS-specific cardiovascular risk factors by their treating physician. Conclusions: A potential lack of cardiovascular care might be present in TS women in Germany as the results of this online patient survey suggest. The cardiovascular care of TS patients, particularly cardiac imaging and patient education, needs to receive more attention.
Investigating the Effects of Amino Acid Variations in Human Menin

Human menin is a nuclear protein that participates in many cellular processes, as transcriptional regulation, DNA damage repair, cell signaling, cell division, proliferation, and migration, by interacting with many other proteins. Mutations of the gene encoding menin cause multiple endocrine neoplasia type 1 (MEN1), a rare autosomal dominant disorder associated with tumors of the endocrine glands. In order to characterize the structural and functional effects at protein level of the hundreds of missense variations, we investigated by computational methods the wild-type menin and more than 200 variants, predicting the amino acid variations that change secondary structure, solvent accessibility, salt-bridge and H-bond interactions, protein thermostability, and altering the capability to bind known protein interactors. The structural analyses are freely accessible online by means of a web interface that integrates also a 3D visualization of the structure of the wild-type and variant proteins. The results of the study offer insight into the effects of the amino acid variations in view of a more complete understanding of their pathological role.
Short-Term Ingestion of Medium-Chain Triglycerides Could Enhance Postprandial Consumption of Ingested Fat in Individuals with a Body Mass Index from 25 to Less than 30: A Randomized, Placebo-Controlled, Double-Blind Crossover Study

The elimination of obesity is essential to maintaining good health. Medium-chain triglycerides (MCTs) inhibit fat accumulation. However, studies examining energy expenditure and fat oxidation with continuous ingestion of MCTs show little association with the elimination of obesity. In this study, we conducted a randomized, double-blind crossover clinical trial to investigate the effects of continuous ingestion of MCTs on postprandial energy expenditure and ingested long-chain triglycerides (LCTs) oxidation. A daily 2 g of MCTs were ingested for two weeks by sedentary participants with a body mass index (BMI) from 25 (kg/m2) to less than 30. Ingestion of a meal containing MCTs and isotopic carbon-13-labeled (13C) LCTs increased energy expenditure and consumption of diet-derived LCTs, as determined by postprandial 13C carbon dioxide excretion, compared to canola oil as the placebo control. These results indicate that continuous ingestion of MCTs could enhance postprandial degradation of diet-derived fat and energy expenditure in sedentary, overweight individuals.
Kernel Least Logarithmic Absolute Difference Algorithm

Kernel adaptive filtering (KAF) algorithms derived from the second moment of error criterion perform very well in nonlinear system identification under assumption of the Gaussian observation noise; however, they inevitably suffer from severe performance degradation in the presence of non-Gaussian impulsive noise and interference. To resolve this dilemma, we propose a novel robust kernel least logarithmic absolute difference (KLLAD) algorithm based on logarithmic error cost function in reproducing kernel Hilbert spaces, taking into account of the non-Gaussian impulsive noise. The KLLAD algorithm shows considerable improvement over the existing KAF algorithms without restraining impulsive interference in terms of robustness and convergence speed. Moreover, the convergence condition of KLLAD algorithm with Gaussian kernel and fixed dictionary is presented in the mean sense. The superior performance of KLLAD algorithm is confirmed by the simulation results.
Occurrence of Mycosporine-like Amino Acids (MAAs) from the Bloom-Forming Cyanobacteria Aphanizomenon Strains

Mycosporine-like amino acids (MAAs) are widespread in various microbes and protect them against harsh environments. Here, four different Aphanizomenon species were isolated from severely eutrophic waterbodies, Lake Dianchi and the Guanqiao fishpond. Morphological characters and molecular phylogenetic analysis verified that the CHAB5919, 5921, and 5926 strains belonged to the Aphanizomenon flos-aquae clade while Guanqiao01 belonged to the Aphanizomenon gracile clade. Full wavelength scanning proved that there was obvious maximal absorption at 334 nm through purified methanol extraction, and these substances were further analyzed by HPLC and UPLC-MS-MS. The results showed that two kinds of MAAs were discovered in the cultured Aphanizomenon strains. One molecular weight was 333.28 and the other was 347.25, and the daughter fragment patterns were in accordance with the previously articles reported shinorine and porphyra-334 ion characters. The concentration of the MAAs was calibrated from semi-prepared MAAs standards from dry cells of Microcystis aeruginosa PCC7806 algal powder, and the purity of shinorine and porphyra-334 were 90.2% and 85.4%, respectively. The average concentrations of shinorine and porphyra-334 were 0.307–0.385 µg/mg and 0.111–0.136 µg/mg in Aphanizomenon flos-aquae species, respectively. And there was only one kind of MAAs (shinorine) in Aphanizomenon gracile species. ,with a content of 0.003–0.049 µg/mg dry weight among all Aphanizomenon gracile strains. The shinorine concentration in Aphanizomenon flos-aquae was higher than that in Aphanizomenon gracile strains. The total MAAs production can be ranked as Aphanizomenon flos-aquae > Aphanizomenon gracile.
Meaningful Trend in Climate Time Series: A Discussion Based On Linear and Smoothing Techniques for Drought Analysis in Taiwan

Finding significant trends in hydroclimate time series has been deemed an essential task in numerous studies. Despite the existence of various trend detection methods, statistical significance is mostly examined for linear trends and related to the meaningfulness of the found trends. We wish to draw attention to a more general definition of meaningful trends by cross-referencing not only linear but also smoothing techniques. We apply linear regression (LR) and two smoothing techniques based on regularized minimal-energy tensor-product B-splines (RMTB) to the trend detection of standardized precipitation index (SPI) series over Taiwan. LR and both RMTB-based methods identify an overall upward (wetting) trend in the SPI series across the time scales in Taiwan from 1960 to 2019. However, if dividing the entire time series into the earlier (1960–1989) and later (1990–2019) sub-series, we find that some downward (drying) trends at varied time scales migrate from southcentral–southwestern to eastern regions. Among these significant trends, we have more confidence in the recent drying trend over eastern Taiwan since all the methods show trend patterns in highest similarity. We also argue that LR should be used with great caution, unless linearity in data series and independence and normality in residuals can be assured.
Research on Secure Communication on In-Vehicle Ethernet Based on Post-Quantum Algorithm NTRUEncrypt

In the context of the evolution of in-vehicle electronic and electrical architecture as well as the rapid development of quantum computers, post-quantum algorithms, such as NTRUEncrypt, are of great significance for in-vehicle secure communications. In this paper, we propose and evaluate, for the first time, a NTRUEncrypt enhanced session key negotiation for the in-vehicle Ethernet context. Specifically, the time consumption and memory occupation of the NTRUEncrypt Elliptic Curve Diffie–Hellman (ECDH), and Rivest–Shamir–Adleman (RSA) algorithms, which are used for session key negotiation, are measured and compared. The result shows that, besides the NTRUEncrypt’s particular attribute of resisting quantum computer attacks, the execution speed of session key negotiation using NTRUEncrypt is 66.06 times faster than ECDH, and 1530.98 times faster than RSA at the 128-bit security level. The memory occupation of the algorithms is at the same order of magnitude. As the transport layer security (TLS) protocol can fulfill most performance requirements of the automotive industry, post-quantum enhanced session key negotiation will probably be widely used for in-vehicle Ethernet communication.
Intelligent Queuing System Based on Fingerprint Recognition

An intelligent queuing system based on fingerprint recognition is introduced to ease the queue-jumping phenomenon in urban ticketing halls during the peak travel period.The system is constituted of fingerprint recognition module,MCU,voice chip,liquid crystal display and other hardware devices.Its feasibility is proved in the experiment.Passengers only need to buy a ticket through fingerprint input and fingerprint authentication.Because of the uniqueness of fingerprints,the system realized a function called"one person one ticket",it can effectively resolve the queue-jumping phenomenon.
Diet Selection by the Italian Hare (Lepus corsicanus de Winton, 1898) in Two Protected Coastal Areas of Latium

Simple Summary In order to better understand the ecological niche of the Italian hare, we evaluated the diet selection of the species in two protected areas of the Latium coastal environment. The main results emerging from our study were: the wide feeding spectrum of the Italian hare; the high incidence of grasses in dry and in wet season diets; the low number of plant species ingested at relatively high rates; the plastic feeding behaviour of this hare, as diet preferences changed with the variety and abundance of food species. These results highlighted the great adaptability of the species to different niches and the influence of the floristic composition on its feeding habits. In the Italian hare, the assessment of habitat suitability is of strategic importance for its conservation. In particular, feeding preferences of the species may lead to defining some food items as key plant species for identifying its elective habitat and, hence, planning effective re-introduction initiatives. Abstract This study was focused on the diet and feeding behaviour of Lepus corsicanus in two protected coastal areas of Latium, Castelporziano Presidential Estate (CPE) and Circeo National Park (CNP). Plant frequency was assessed by the quadrat method, while diet composition was determined by microhistological analysis of faecal samples. Over the year, the Italian hare fed on 185 of the 229 plant species identified in vegetation, with most of them ingested in low percentages (≤1%). During the dry season (DS), in both areas, Brachypodium sylvaticum, Cynodon dactylon, and Avena fatua were among the most consumed species. In the wet season (WS) the most common plant species in diet were B. sylvaticum, Poa trivialis, and Carex distachya in CPE and Dactylis glomerata, Cynosurus echinatus, and Spartium junceum in CNP. In both sites, considering the annual selection of life forms, grasses and leguminous forbs were preferred, while non-leguminous forbs and shrubs were used less than expected according to their availability. ANOSIM analysis showed significant differences between sites in DS and WS diets. Our study evidenced that the Italian hare behaved as generalist, revealing its capability for exploiting several plant species and to adapt its diet preferences to space-time variation of food availability.
Simulation Research on Detection of Driver'S Fatigue

Study the driver's fatigue state detection problems.In order to improve the recognition correct rate of driver fatigue state,we put forward a kind of support vector machine in driver fatigue state detection method.First,a sensor was used to acquire the steering wheel angle and road offset values which were then was digitized and input to a support vector machine for learning to establish the driver fatigue state detection model.The experimental results show that the method is very good,which can overcome the traditional algorithm's detecting defects,improve the driver's fatigue state detection accuracy rate,and meet the requirements of driving fatigue detection.
Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?

Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the scientific and medical communities with innovative strategies specifically targeting these organisms. In this review, we present an overview of the diversity of the phosphatome as well as the variety of functions that phosphatases display throughout the Apicomplexan parasites’ life cycles. We also discuss how this diversity could be used for the design of innovative and specific new drugs/therapeutic strategies.
From Legacy Data to Intertwingled Historical Census and Survey Data

Context Although conceived early in the 1960s by Nelson [22] in his vision of a digital research environment for a historian, such hypertext-based research tools [e. g. 8] have not prevailed in the daily work of historians due to the problem of incomplete or inaccurately prepared sources [cf. 30]—i. e. the lack of adequately modeled research data. Nowadays, the linked data paradigm provides a solution for source-oriented [cf. 14, p. 190 f. ] modeling and integration of historical sources as research data.