Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary fat and adult diseases and the implications for childhood nutrition: an epidemiologic approach 1–3

Reducing dietary saturated fat by 7% of energy, a realistic target, would reduce serum cholesterol by 10% and mortality from ischemic heart disease by 25–30%. Randomized trials show that this mortality reduction is attained rapidly, usually by the third year after initial reduction of dietary saturated fat intake. Dietary change in adulthood may therefore reverse the adverse health effects of a high-fat diet in childhood. In the absence of such change, however, dietary fat in childhood may increase the risk of cardiovascular disease in adult life because of a longer duration of exposure to a high-fat diet. Assessing the effects of diet on cancer risk is more difficult. The intermediary markers of risk that are analogous to serum cholesterol are less satisfactory and there are negligible trial data. Cohort studies of diet and cancer, although subject to bias, do not favor a direct causal relation between dietary fat and cancer. But a reduction in risk is likely when dietary fat is reduced as part of a general change toward a healthier diet. The trend toward increased energy intake and body size in childhood and relatively low dietary fiber contribute to the decreasing age at menarche, which is associated with an increased risk of breast cancer. Low dietary fiber, low fruit and vegetable consumption, and high red meat consumption are associated with colon cancer and other cancers, and important causal effects of diet on cancer are likely. As with cardiovascular disease, this dietary trend that is commenced in childhood is likely to increase age-specific rates of colon cancer in adult life, but the risk may be reversed with later dietary change. Am J Clin Nutr 2000;72(suppl):1291S–6S.
Managing safety data: the TOKAI experience for the ANSPs

Socio-technical systems such as the Air Traffic Management (ATM) system have become increasingly complex in the last decades and a call for systematic data analyses is necessary to manage operations and related criticalities. In the context of risk and safety management, it thus become central to allow structured and complete in-depth understanding of safety performance, especially in relation to safety events (accidents, incidents, near-misses). Following relevant international and EU regulations (ICAO Annex 13, EC Directive 2003/42/EC, EU 376/2014, etc.), EUROCONTROL developed the TOKAI (Toolkit for ATM Occurrence Investigation) as a tool to support occurrence investigation and generate a structured repository for safety data management. This paper aims to present the general features of TOKAI, also in line with the legislative context. The paper provides an overview on how incident data from TOKAI may contribute to support an effective data management in aviation, by means of exemplar statistical analysis to support the decision-making at different organizational levels. Selection and peer-review under responsibility of the scientific committee of the International Conference on Air Transport – INAIR 2018.
A Study on Architecture of a Cyber Checkpoint Model in the Cloud Computing Environment

In this paper, we designed cyber checkpoint model for protecting user information and system resources in cloud computing environment. Our proposed cyber checkpoint model is a system that performs primary inspection process on all traffic over the internet. And it identifies all threats and blocks them for securing a cloud computing elements. The cyber checkpoint model consists of three components such as incoming traffic checkpoint, internal traffic checkpoint, and host-based threat checkpoint. The proposed model checks the safety of incoming traffic and binary file, and tracks traffic including risk factors. And it also judges attack traffics on system and storage, detects attack by virtual machine or the host belong to the virtual machine. Our model is able to provide stable and reliable service by blocking beforehand various threats could be occurred in cloud computing environment.
AIS Electronic Library (AISeL) The Relationship between SME Owner’s Personality, Facebook Usage and Organizational Performance

SMEs usage of Facebook for business is growing tremendously. Majority of the studies on Facebook usage are based on individual perspective and some are from organizational perspective. However, not many studies had investigated the actual impact of Facebook usage on organizational performance. This paper investigates the influence of personality traits of SME owners on Facebook usage and its subsequent impact on organizational performance. A total of 259 SMEs responded to the survey and the result of the survey showed that perceived desirability and openness of SME owners positively influences Facebook usage. Facebook usage also has a positive impact on both organizational financial and non-financial performances. This study provided a clearer view on the real importance of Facebook and its benefits. The results would motivate and guide organizations in the adoption (composite reliability), indicator reliability (outer loadings), convergent validity (average variance extracted), and discriminant validity.
The Wild-Type Hepatitis C Virus Core Inhibits Initiation of Antigen-Speciﬁc T- and B-Cell Immune Responses in BALB/c Mice (cid:1)

In this study, the effects of wild-type and deletion mutant hepatitis C virus (HCV) core proteins on the induction of immune responses in BALB/c mice were assessed. p2HA-C145-S23, encoding a core protein with the C-terminal 46 amino acids truncated, signiﬁcantly produced stronger antibody and cellular responses than p2HA-C191-S23. The induction of immune responses by p2HA-C145-S23 was dose dependent. However, increasing the doses or repeated administration did not enhance immune responses by the wild-type core protein. In addition, p2HA-C191- S23 was apparently able to interfere with the priming of speciﬁc immune responses by p2HA-C145-S23 when the two were coadministered. These results demonstrated that the wild-type HCV core protein itself could inhibit the priming of immune responses in the course of a DNA vaccination, whereas the truncated HCV core protein could provide potential applications
Random cross-species identification of a gene encoding for an inorganic pyrophosphatase in the uncultivable hemotrophic bacterium Mycoplasma

: Zusammenfassung In der vorliegenden Arbeit wurden zwei M. suis-Genbibliotheken auf die Gene Enolase und Pyruvatdehydrogenase (PDH) untersucht. Für die „cross species identification“ wurden DNA Sonden aus dem Enolase- und PDH-Gen des nahe verwandten humanpathogenen Agens M. pneumoniae verwendet. Um die in den Genbibliotheken zu etwa 90% enthaltenen Escherichia (E.) coli-Klone mit Inserts aus porziner DNA auszusortieren, wurden sämtliche Klone zunächst mit einer Biotin-markierten DNA-Sonde gegen porzine DNA hybridisiert. Sämtliche Klone mit positiven Hybridisierungsreaktio-nen mit porziner DNA wurden ausselektiert. Bei insgesamt 600 Klonen fiel diese DNA-Hybridisierung negativ aus, so dass sie als potentielle Träger eines M. suis-DNA-inserts gelten konnten. In Southern blot-Analysen der 600 E. coli-Klone mit den DNA-Sonden gegen M. pneumoniae Enolase und PDH kon-nten 30 Klone identifiziert werden, die mit einer der beiden Sonden spezifisch hybridisierten. Durch Sequenzanalyse der DNA-inserts wurde das Gen für eine M. suis-spezifische anorganische Pyrophosphatase (ppA) gefunden. Das ppA-Gen hat eine Grösse von 495 bp; die Homologie zu analogen Genen anderer pathogener Mycoplasmen 53-55%. Der GC-Gehalt beträgt 32%. Die prokaryotische anorganische Pyrophosphatase spielt bakteriellen Energiestoffwechsel sowie bakteriellen Protein-und Nukleinsäuremetabolismus eine wichtige Rolle und könnte ein neues Target für antibakterielle Wirk-stoffe darstellen. Summary Genome sequence analysis of Mycoplasma suis is hampered due to the lack of an appropriate in vitro cultivating system. The organism has still to be purified from blood samples of experimentally infected pigs, which is linked with technical difficulties. Therefore, little is known about the genome of M. suis. For this work a cross-species random approach, based upon Southern blot, was considered in order to identify novel genes. Two shotgun M. suis genomic libraries were screened using either M. pneumoniae enolase or pyruvate dehydrogenase (PDH) probes. Using these two enzymes as probes is based on recent gained insights of their pathogenicity in mycoplasma infections. Following this strategy the complete open reading frame of a putative M. suis inorganic pyrophosphatase (ppA) was found by hybridizising with a M. pneumoniae enolase probe. The positive hybridization signal is considered to result from the DNA homology of 45% between the M. suis ppA and the M. pneumoniae enolase. The encoding gene ppA is 495 bp in size. The deduced amino acid sequence showed an overall similarity of 53 to 55% with inorganic pyrophosphatases of other pathogenic mycoplasmas, and a GC-content of 32%. This study demonstrates the feasibility and the encountered difficulties of a random cross- species approach to identify novel genes of an uncultivable agent like M. suis.
Implementation of Computer-Aided Design of Fixture in the Educational Process

– This article describes the implementation of Computer – aided design of fixture in the educational process. The introduction of this article describes the drilling technology and the fixtures in a theoretical approach. In the second part of this article, the current state of drilling technology and fixtures is analysed. Described is a part for which it is necessary to design a fixture for the drilling process. The third part of this article is focused on the description of fixture design creation for selected part. The design is created in the Autodesk Inventor which is integrated into the educational process at the Faculty of Manufacturing Technologies. The final part of this article provides an overall evaluation of suggested solution from the practical and educational point of view.
Density matrix modelling of Ge/GeSi bound-to-continuum terahertz quantum cascade lasers

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher’s website.
CFD Modeling on Hydrodynamic Characteristics of Multiphase Counter-Current Flow in a Structured Packed Bed for Post-Combustion CO2 Capture

Solvent-based post combustion CO2 capture is a promising technology for industrial application. Gas-liquid interfaces and interactions in the packed bed are considered one of the key factors affecting the overall CO2 absorption rate. Understanding the hydrodynamic characterizations within packed beds is essential to identify the appropriate enhanced mass transfer technique. However, multiphase counter-current flows in the structured packing typically used in these processes are complicated to visualize and optimize experimentally. In this paper, we aim to develop a comprehensive 3D multiphase, counter-current flow model to study the liquid/gas behavior on the surface of structured packing. The output from computational fluid dynamics (CFD) clearly visualized the hydrodynamic characterizations, such as the liquid distributions, wettability, and film thicknesses, in the confined packed bed. When the liquid We (Weber number) was greater than 2.21, the channel flow became insignificant and flow streams became more disorganized with more droplets at larger sizes. The portion of dead zones is decreased at higher liquid We, but it cannot be completely eliminated. Average film thickness was about 0.6–0.7 mm, however, its height varied significantly.
A Comparative Simultaneous Doppler-Catheterization Study

Copyright © 2000 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 2000;102;1788-1794 Circulation Redfield and A. J. Tajik S. R. Ommen, R. A. Nishimura, C. P. Appleton, F. A. Miller, J. K. Oh, M. M. Doppler-Catheterization Study Estimation of Left Ventricular Filling Pressures : A Comparative Simultaneous Clinical Utility of Doppler Echocardiography and Tissue Doppler Imaging in the http://circ.ahajournals. org/cgi/content/full/102/15/1788 located on the World Wide Web at: The online version of this article, along with updated information and services, is
Identiﬁcation of Thlaspi caerulescens Genes That May Be Involved in Heavy Metal Hyperaccumulation and Tolerance. Characterization of a Novel Heavy Metal Transporting ATPase 1

Thlaspi caerulescens is a heavy metal hyperaccumulator plant species that is able to accumulate extremely high levels of zinc (Zn) and cadmium (Cd) in its shoots (30,000 m g g 2 1 Zn and 10,000 m g g 2 1 Cd), and has been the subject of intense research as a model plant to gain a better understanding of the mechanisms of heavy metal hyperaccumulation and tolerance and as a source of genes for developing plant species better suited for the phytoremediation of metal-contaminated soils. In this study, we report on the results of a yeast ( Saccharomyces cerevisae ) complementation screen aimed at identifying candidate heavy metal tolerance genes in T. caerulescens . A number of Thlaspi genes that conferred Cd tolerance to yeast were identiﬁed, including possible metal-binding ligands from the metallothionein gene family, and a P-type ATPase that is a member of the P 1B subfamily of purported heavy metal-translocating ATPases. A detailed characterization of the Thlaspi heavy metal ATPase, TcHMA4 , demonstrated that it mediates yeast metal tolerance via active efﬂux of a number of different heavy metals (Cd, Zn, lead [Pb], and copper [Cu]) out of the cell. However, in T. caerulescens , based on differences in tissue-speciﬁc and metal-responsive expression of this transporter compared with its homolog in Arabidopsis ( Arabidopsis thaliana ), we suggest that it may not be involved in metal tolerance. Instead, we hypothesize that it may play a role in xylem loading of metals and thus could be a key player in the hyperaccumulation phenotype expressed in T. caerulescens . Additionally, evidence is presented showing that the C terminus of the TcHMA4 protein, which contains numerous possible heavy metal-binding His and Cys repeats residues, participates in heavy metal binding. When partial peptides from this C-terminal domain were expressed in yeast, they conferred an extremely high level of Cd tolerance and Cd hyperaccumulation. The possibilities for enhancing the metal tolerance and phytoremediation potential of higher plants via expression of these metal-binding peptides are also discussed.
Predominantly by Antigen Transfer In Vivo Priming by DNA Injection Occurs

DNA vaccines can stimulate both humoral and cytolytic immune responses. Although bone marrow-derived elements present the expressed Ag, the mechanisms for acquiring immunogenic peptides have yet to be fully elucidated. APCs may become directly transfected by plasmid DNA or process extracellular proteins produced by other transfected cells. Using a transactivating plasmid system and bone marrow chimeras, we show that both mechanisms appear to be involved; however, the bulk of the immune response is dependent on expression of Ag by nonlymphoid tissues and transfer to APCs. These in vivo studies are the ﬁrst to deﬁne the role of transfected nonlymphoid cells in generating Ag for presentation by bone marrow-derived APCs after needle injection with plasmid DNA. The Journal of Immunology, 1999, 163: 4721–4727.
NDT_A_252008 1737..1744

Department of Neurology, Taizhou First People’s Hospital, Taizhou, Zhejiang, People’s Republic of China Purpose: Increasing evidence suggests that both vascular endothelial growth factor (VEGF) and synaptic failure have been involved in the pathogenesis of Alzheimer’s disease (AD). However, it is not clear whether CSF VEGF levels are associated with synaptic function in living human. Patients and Methods: In the present study, we included a total of 291 older individuals, including 83 individuals with normal cognition (NC), 143 individuals with mild cognitive impairment (MCI) and 65 patients with AD. Several linear regression models were conducted to examine the associations of CSF VEGF with CSF neurogranin levels (NG, reflecting synaptic degeneration) when controlling for other potential confounding factors, including age, gender, years of education, clinical diagnosis, APOE4 genotype and CSF β-amyloid 42 (Aβ 42) levels. Results: There was no significant difference in VEGF levels between the three diagnostic groups. In the pooled sample, females had significantly lower levels of VEGF than males. Aβ-positive (CSF Aβ 42 < 192 pg/mL) individuals had lower levels of VEGF than Aβ-negative individuals. However, the relationships between VEGF and NG levels were not modified by disease stage. Finally, we found that CSF VEGF levels were associated with NG levels with adjustment of age, gender, years of education, clinical diagnosis, APOE4 genotype and CSFAβ 42 levels. Conclusion: CSF VEGF levels were associated with NG independent of AD pathology and disease stage.
Experimental Evaluation of Pyroclastic Deformation on Mechanical Properties of Grès Porcelain Stoneware

Grès Porcelain stoneware is a ceramic with a compact, hard, coloured and non-porous body. A very prominent patented technology permits to obtained bent porcelain tiles as innovative solutions for a modern architecture. This technology is grounded on a proper combination of heavy machining by cutting tools and secondary firing in a kiln. This paper investigates the alteration in behaviour of porcelain passing by the bending process comparing the mechanical proprieties by flexural, compression and impact tests.
NO ASYMMETRIES OF LONG-ACTING INHIBITION 1 No hemispheric asymmetries in long-acting cortical inhibition in young adults using TMS-EEG

It is well established that fine motor control is asymmetrical: this is known as handedness. Handedness is controlled by cortical motor processes, including longacting inhibition. Long-acting cortical inhibition is asymmetric between the left and right hemispheres. Therefore, asymmetries of handedness may be attributable to asymmetries in long-acting inhibition. Asymmetries of long-acting inhibition have previously been tested using a measure of corticospinal excitability, but have not been previously investigated using combined transcranial magnetic stimulation (TMS) and electroencephalography (TMS-EEG), a measure of cortical inhibition not influenced by spinal excitability. This study aimed to determine if long-acting cortical inhibition is asymmetrical using TMS-EEG and to investigate any associations of asymmetrical inhibition with fine motor control. In young adults (n = 14) fine motor control was measured using the Purdue Pegboard task. EEG was used to record the cortical responses to paired-pulse, single-pulse and sham TMS. Results showed no asymmetry in fine motor control using the Purdue Pegboard task and no asymmetries of long-acting inhibition between the left and right hemispheres using TMS-EEG. There was no significant difference between the response to sham and single-pulse stimulation, suggesting that the cortical response to TMS was influenced by auditory or physiological artefacts. There were no associations between TEPs of long-acting inhibition and fine motor control. Overall, there were no conclusive results whether asymmetries of long-acting inhibition are replicable using TMS-EEG. Further investigation of the importance of LICI as a neural underpinning of handedness is important to better understanding the workings of handedness and fine motor control.
A3P: A Tool to Provide Privacy Policy Based Security of Images on Content Sharing Sites

- Now a days social Media’s are more powerful so that online users would like to share their image contents on the social sites but providing privacy to the images shared by users become much difficult because users may share their personal information inadvertently. In ordered to overcome such cases, we proposed a tool called Adaptive Privacy Policy Prediction (A3P) to allow the users to personalise their privacy policy. Social settings, image content and metadata are the indicators of user privacy preferences. According to this proposedscheme a two level framework defines the best privacy policy from the history of the user and user’s images being uploaded. This scheme works based upon the image classification framework for image categories and on a prediction algorithm to predict policy for the uploaded image in according to the user social features.
Puri¢cation and characterization of outer membrane protein P6, a vaccine antigen of non-typeable Haemophilus in£uenzae

Outer membrane protein P6 is a promising vaccine antigen with potential to prevent infections caused by non-typeable Haemophilus influenzae . A convenient and reliable method for the purification of P6 and an assessment of the purity, yield, protein structure, antigenicity and immunogenicity of the purified protein are described. The method begins with intact H. influenzae and utilizes a series of incubations and centrifugations using a single buffer to remove all cell components with the exception of the peptidoglycan to which the P6 is associated. P6 is dissociated from the complex with heat and the insoluble peptidoglycan is removed by centrifugation. The procedure yields highly purified P6. Contamination with lipooligosaccharide is less than 0.025 endotoxin U per W g P6. The yield of P6 is approximately 2 mg of P6 per l H. influenzae culture. The purified P6 retains both the secondary and tertiary structure as measured by circular dichroism and analysis with monoclonal antibodies. The purified P6 is immunogenic in animals. A convenient method for purifying P6 which retains antigenicity and immunogenicity will be an important tool for future studies of the vaccine potential of P6. (cid:223) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Edge-Sharpener: A geometric filter for recovering sharp features in uniform triangulations

3D scanners, iso-surface extraction procedures, and several recent geometric compression schemes sample surfaces of 3D shapes in a regular fashion, without any attempt to align the samples with the sharp edges and corners of the original shape. Consequently, the interpolating triangle meshes chamfer these sharp features and thus exhibit significant errors. The new Edge-Sharpener filter introduced here identifies the chamfer edges and subdivides them and their incident triangles by inserting new vertices and by forcing these vertices to lie on intersections of planes that locally approximate the smooth surfaces that meet at these sharp features. This post-processing significantly reduces the error produced by the initial sampling process. For example, we have observed that the L 2 error introduced by the SwingWrapper 9 remeshing-based compressor can be reduced down to a fifth by executing Edge-Sharpener after decompression, with no additional information.