Miracle-dz/UniFAR-FTUs huggingface dataset:
Morphometric characterization of endometrial glands using quantitative cytology.

OBJECTIVE To determine the usefulness of the combination of confocal laser scanning microscopy (CLSM), image cytometry and three-dimensional (3D) imaging for analyzing architectural changes indicative of endometrial hyperplasia and grade 1 adenocarcinoma. STUDY DESIGN Papanicolaou-stained endometrial samples (n = 180) were analyzed for specific cellular characteristics and analyzed by CLSM. Confocal images were obtained and then analyzed cytometrically and used for 3D reconstruction. RESULTS Values obtained after image cytometry and 3D imaging increased significantly (P < .01) with the degree of cellular atypia. CONCLUSION The combination of CLSM, image cytometry and 3D imaging is a valuable method for differential diagnosis of endometrial hyperplasia and grade 1 adenocarcinoma.
Trust-based Collaborative Filtering

Collaborative Filtering is one of the most successful techniques of Recommender Systems. Despite its success, similarity-based Collaborative Filtering methods suffer from inherent weakness: users tend to rate few items. As a result, the similarity is not easily computed. This paper aims to solve the above problem by introducing the trust metric into Collaborative Filtering. We develop a novel computation model of trust by incorporating the tastes of users. Then we propagate trust throughout the trust relationship network, and more potential neighbors can be found. At last, we make recommendations based on trust-based Collaborative Filtering. Experimental results on a real extremely sparse dataset have shown best performance of our method in terms of MAE and Coverage when compared with similarity-based Collaborative Filtering methods.
Effects of load characteristics on the damping performance of Power System Stabilizers for inter-area oscillations

Load characteristics are known to have an effect on the performance of a Power System Stabilizer (PSS) while damping inter-area oscillation. In this paper, conventional and Wide Area Control System (WACS) based PSS designs are comparatively assessed. The conventional PSS utilizes local rotor speed as its input whereas the WACS-based PSS can use both local and remote generator rotor speeds. From existing publications, the damping effectiveness of conventional PSS has been reported to vary with respect to different load characteristics. This paper evaluates the damping effectiveness of potential WACS-based PSS under different load characteristics. Simulations are conducted using different load models and load magnitudes on a two area network. Results are compared to conventional PSS oscillation damping.
Referential gaze and word learning in adults with autism

While typically developing children can use referential gaze to guide their word learning, those with autism spectrum disorder are often described to have problems with that. However, some researchers assume that the ability to follow gaze to select the correct referent can develop in autism later compared to typically developing individuals. To test this assumption, we compared the performance of adults with and without autism on a word learning task while recording their gaze behavior using an eye tracker. Results showed that both groups mostly chose the correct referent, but less so for the autism spectrum disorder group when the distractor’s saliency was increased, suggesting that the ability to learn novel words by referring to gaze develops in autism spectrum disorder, but not fully, relative to their typically developing peers.
Control and Analysis of Energetic Swarm Systems

In this paper, an M-member continuous-time swarm problem is investigated considering the swarm bulk kinetic energy and internal kinetic energy. The motion of each individual is determined by an external input, a velocity damping term, and attraction/repulsion from the other individuals. A swarm temperature variable is defined to study the internal kinetic energy properties of the swarm. A controller is developed such that the swarm center can follow any desired trajectory with different corresponding swarm temperatures. Simulation is used to validate the results and provide more insight into the problem of swarm cohesion.
Finding an optimal seating arrangement for employees

The paper deals with modelling a specific problem called the Optimal Seating Arrangement (OSA) as an Integer Linear Program and demonstrated that the problem can be efficiently solved by combining branch-and-bound and cutting plane methods. OSA refers to a specific scenario that could possibly happen in a corporative environment, i.e. when a company endeavors to minimize travel costs when employees travel to an organized event. Each employee is free to choose the time to travel to and from an event and it depends on personal reasons. The paper differentiates between using different travel possibilities in the OSA problem, such as using company assigned or a company owned vehicles, private vehicles or using public transport, if needed. Also, a user-friendly web application was made and is available to the public for testing purposes.
Transfer Hydrogenation of Ketones and Activated Olefins Using Chelating NHC Ruthenium Complexes

N-Heterocyclic carbene (NHC) ruthenium complexes consisting of different donor substituents attached to the NHC ligand efficiently catalyse the transfer hydrogenation of ketones and of activated olefins in α,β-unsaturated ketones to give saturated alcohols. The most active catalyst precursor contains a tethered olefin as a hemilabile donor site. This complex also converts nitriles and, depending on the reaction conditions, either benzylamines are produced by means of transfer hydrogenation, or amides from formal addition of H2O. Kinetic analysis of the double hydrogenation of α,β-unsaturated ketones indicates fast isomerisation of the enol intermediate to its saturated ketone tautomer prior to the second hydrogenation.
Mild traumatic brain injury in children: Management practices in the acute care setting

Accurate diagnosis, treatment and follow up of children suffering mild traumatic brain injury (MTBI) is important as post‐concussive symptoms and long‐term disability might occur. This research explored the decisions clinicians make in their assessment and management of children with MTBI in acute care settings, and identified barriers and enablers to the delivery of best‐practice care.
Specific Platelet Mediators and Unstable Coronary Artery Lesions: Experimental Evidence and Potential Clinical Implications

We have speculated previously that the abrupt conversion from chronic stable to unstable angina and the continuum to acute myocardial infarction may result from myocardial ischemia caused by progressive platelet aggregation and dynamic vasoconstriction themselves caused by local increases in thromboxane and serotonin at sites of coronary artery stenosis and endothelial injury. Platelet aggregation and dynamic coronary artery vasoconstriction probably result from the local accumulation of thromboxane and serotonin and also relative decreases in the local concentrations of endothelially derived vasodilators and inhibitors of platelet aggregation, such as endothelium-derived relaxing factor (EDRF) and prostacyclin. With severe reductions in coronary blood flow caused by these mechanisms, platelet aggregates may increase, and an occlusive thrombus composed of platelets and white and red blood cells in a fibrin mesh may develop. When coronary arteries are occluded or narrowed for a sufficient period of time by these mechanisms, myocardial necrosis, electrical instability, or sudden death may occur. We believe that unstable angina and acute myocardial infarction are a continuum in relation to the process of coronary artery thrombosis and vasoconstriction. When the period of platelet aggregation or dynamic vasoconstriction at sites of endothelial injury and coronary artery stenosis is brief, unstable angina or non-Q wave infarction may occur. However, when the coronary artery obstruction by these mechanisms is prolonged for several hours, Q wave myocardial infarction results. Chronic endothelial injury and coronary artery stenosis are probably associated with the accumulation of platelets, white and red blood cells, and a fibrin mesh at the site of stenosis and endothelial injury.
Effect of tyrosine hydroxylase gene silencing in CD4+ T lymphocytes on differentiation and function of helper T cells.

OBJECTIVES We explored effect of gene silencing of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines (CAs), in CD4+ T cells on differentiation and function of helper T (Th) cells to provide more evidence for functional significance of lymphocyte-derived CAs. METHODS CD4+ T lymphocytes were isolated and purified from the mesenteric lymph nodes of mice. Recombinant TH miRNA expression vector (pcDNA6.2-GW/EmGFPmiR-TH) was constructed and transfected into concanavalin A (Con A)-activated CD4+ T lymphocytes using nucleofection technology. After incubated for 48 h, these cells were detected for TH gene and protein expression and CA content. Simultaneously, percentage of interferon-γ (IFN-γ)- and interleukin-4 (IL-4)-producing cells and levels of IL-2, IFN-γ, tumor necrosis factor (TNF), IL-4 and IL-5 in culture supernatants of Con A-stimulated CD4+ T cells were examined by flow cytometric analysis. RESULTS CD4+ T lymphocytes with TH RNAi expressed less TH mRNA and protein and synthesized less CAs including norepinephrine, epinephrine and dopamine than control cells with mock transfection. The silencing of TH gene in CD4+ T lymphocytes reduced percentage of IL-4-producing cells and elevated ratio of IFN-γ-producing cells to IL-4-producing cells, although it did not alter proportion of IFN-γ-producing cells. The Th1 cytokines, IL-2, IFN-γ and TNF, were increased, but the Th2 cytokines, IL-4 and IL-5, were decreased in the culture supernatants of Con A-stimulated CD4+ T lymphocytes that were transfected with TH miRNA. CONCLUSION TH gene silencing attenuates TH expression and CA synthesis in CD4+ T lymphocytes and promotes polarization of differentiation and function towards Th1 cells.
First Autoclave‐Sterilized Platelet‐Additive Solution Containing Glucose with a Physiological pH for the Preparation of Plasma‐Poor Platelet Concentrates

The glucose‐free platelet‐additive solution (termed AR solution), developed by Adams and Rock [Transfusion 1988;28:217—220], was modified by adding glucose as an energy substrate for platelets and maltose to prevent platelet lysis and by replacing sodium gluconate with sodium phosphate for better pH maintenance. The new platelet‐additive solution (termed Seto solution) contained 90 mM NaCl, 5mM KCl, 3mM MgCl2, 17 mM tri‐sodium citrate, 4.9 mM NaH2PO4, 20.1 mM Na2HPO4, 23 mM sodium acetate, 28.8 mM maltose, and 23.5 mM glucose with a pH of 7.4. The solution was sterilized by autoclaving in plastic bags in nitrogen to prevent glucose caramelization at high pH. Plasma‐poor platelet concentrates prepared by adding Seto solution to the pelleted platelet buttons were stored in a LE‐2 polyolefin bag at 22 °C with constant agitation for 5 days. The platelets suspended in Seto solution maintained oxygen consumption at a rate of 1.1 nmol/min/109 platelets after 5‐day storage, with glucose consumption and lactate production rates of 0.5 ± 0.2 and 1.2 ± 0.2 nmol/min/109 platelets, respectively. This resulted in a final mean pH of 7.0. Those suspended in AR solution ceased glycolysis within 3 days because residual plasma glucose had been consumed. This was associated with decreases in percent hypotonic shock response and aggregation induced by adenosine diphosphate and collagen. Lactate dehydrogenase discharge in AR solution was 5 and 8 times higher at day 3 and day 5, respectively, than that of Seto solution. Morphologically, there were no ballooned platelets after storage in Seto solution. Platelets stored in Seto solution were nearly equal to those stored in plasma. Conclusions: Steam‐sterilized Seto‐additive solution caused better storage of platelets for 5 days than AR solution, suggesting that glucose is important for optimal storage. Phosphate acts as an effective buffer and maltose stabilizes platelet volumes.
Digital LQR steady-state optimal control with feedforward for nonminimum phase boost DC-DC converter

This paper presents a perfect optimal control for nonminimum phase boost DC-DC converters by adopting a combination of feedback and feedforward controller. A linear quadratic regulator (LQR) feedback controller is firstly designed and proposed to have the following improvements. Firstly, integral control by state augmentation is adopted in order to and eliminate the steady-state errors. Secondly, feedback gain and estimator gain are calculated offline based on LQR steady-state optimal control method and steady-state Kalman filter. Then, the problems of integral wind-up protection is also handled. A feedforward controller is then proposed to eliminate the phase error caused by right half phase zero (RHPZ) emerged in nonminimum phase of boost DC-DC converters. The feedforward controller is implemented by zero phase error tracking control (ZPETC) technique because the inverse of nonminimum phase system is unstable. Finally, the proposed controller has been implemented on NI CompactRio platform for boost converter voltage control. The experimental results clearly show the proposed controller offers better performance as compared to conventional digital compensation controller.
Activated protein C inhibits lipopolysaccharide‐induced nuclear translocation of nuclear factor κB (NF‐κB) and tumour necrosis factor α (TNF‐α) production in the THP‐1 monocytic cell line

Activated protein C (APC) protects against sepsis in animal models and inhibits the lipopolysacharide (LPS)‐induced elaboration of proinflammatory cytokines from monocytes. The molecular mechanism responsible for this property is unknown. We assessed the effect of APC on LPS‐induced tumour necrosis factor α (TNF‐α) production and on the activation of the central proinflammatory transcription factor nuclear factor‐κB (NF‐κB) in a THP‐1 cell line. Cells were preincubated with varying concentrations of APC (200 µg/ml, 100 µg/ml and 20 µg/ml) before addition of LPS (100 ng/ml and 10 µg/ml). APC inhibited LPS‐induced production of TNF‐α both in the presence and absence of fetal calf serum (FCS), although the effect was less marked with 10% FCS. APC also inhibited LPS‐induced activation of NF‐κB, with APC (200 µg/ml) abolishing the effect of LPS (100 ng/ml). The ability of APC to inhibit LPS‐induced translocation of NF‐κB is likely to be a significant event given the critical role of the latter in the host inflammatory response.
The Human Variome Project Beijing meeting

The Human Variome Project Beijing Meeting, a joint meeting of the Human Variome Project Consortium and the Human Variome Project Chinese Node, was held in Beijing, 8th–12th of December, 2011. The aim of the Human Variome Project is to ensure that all information on genetic variation can be collected, curated, interpreted and shared freely and openly. The meeting officially welcomed the Human Variome Project Chinese Node as a partner of the Human Variome Project and focused on those areas where collaborations between China and the global Human Variome Project Consortium are required to develop and extend the coverage of international gene/disease specific databases.
Substation switching electromagnetic transient analysis using the time domain integral equation with a high order implicit scheme

A fast electric field integral in time domain using the uneven discretization and the implicit scheme is proposed to calculate the switching electromagnetic transient at a substation. The switching transient currents and the resultant radiated electromagnetic field are calculated. The propose d approach has the strength to model the bus system at a substation with a more complicated and realistic configuration that is difficult to simulate using the circuit-based method, because all the electromagnetic couplings within the bus system are included globally. The proposed method might be one of good candidates to predicate the EMI level at a substation.
Observation of femtosecond molecular dynamics via pump–probe gas phase x-ray scattering

We describe a gas-phase x-ray scattering experiment capable of capturing molecular motions with atomic spatial resolution and femtosecond time resolution. X-ray free electron lasers can deliver intense x-ray pulses of ultrashort duration, making them suitable to study ultrafast chemical reaction dynamics in an ultraviolet pump, x-ray probe scheme. A cell diffractometer balances sample flow with gas density and laser focusing conditions to provide adequate scattering vector resolution with high signal intensity and near-uniform excitation probability. Images from a pixel-array x-ray detector, spatially and electronically calibrated, allow for detection of scattering intensity changes below 1%. First experiments on the ring-opening reaction of 1,3-cyclohexadiene to form 1, 3, 5-hexatriene show a rapid initial reaction on an 80 fs time scale.
International Conference on Knowledge Based and Intelligent Information and Engineering Systems , KES 2017 , 6-8 September 2017 , Marseille , France Local regression algorithms based on centroid clustering methods

The paper analyzes different version of the mini-model method (MM-method) which are based on centroid clustering algorithms. The article introduces two new versions of the method which are based on k-medoids method and the fuzzy clustering methods c-means algorithm. The MM-method is an instance-based learning algorithm. It operates only on data from the local neighborhood of a query. The local neighborhood is created by clustering algorithms. It makes the learning procedure simpler, because in the previous version, the neighborhood of query was based on multidimensional polytopes. The article also presents comparison between different versions of the MM-method and other instance-based learning algorithms. c 2017 The uthors. Published by Elsevier B. r-r i r r s si ilit f I t r ti l.
NETBAGs: a network-based clustering approach with gene signatures for cancer subtyping analysis.

AIM To evaluate gene signature and network-based approach for cancer subtyping and classification. MATERIALS & METHODS Here we introduced NETwork Based clustering Approach with Gene signatures (NETBAGs) algorithm, which clustered samples based on gene signatures and identified molecular markers based on their significantly expressed gene network profiles. RESULTS Applying NETBAGs to multiple independent breast cancer datasets, we demonstrated that the clustering results were highly associated with the clinical subtypes and clearly revealed the genomic diversity of breast cancer samples. CONCLUSION NETBAGs algorithm is able to classify samples by their genomic signatures into clinically significant phenotypes so that potential biomarkers can be identified. The approach may contribute to cancer research and clinical study of complex diseases.
Tissue-specific differential antitumour effect of molecular forms of fractalkine in a mouse model of metastatic colon cancer

Background and aims: Fractalkine, a chemokine that presents as both a secreted and a membrane-anchored form, has been described as having tumour-suppressive activities in standard subcutaneous models. Here, we investigate the antitumour effect of fractalkine, in its three molecular forms, in two orthotopic models of metastatic colon cancer (liver and lung) and in the standard subcutaneous model. Methods: We have developed models of skin tumours, liver and pulmonary metastasis and compared the extent of tumour development between C26 colon cancer cells expressing either the native, the soluble, the membrane-bound fractalkine or none. Results: The native fractalkine exhibits the strongest antitumour effect, reducing the tumour size by 93% in the skin and by 99% in the orthotopic models (p<0.0001). Its overall effect results from a critical balance between the activity of the secreted and the membrane-bound forms, balance that is itself dependent on the target tissue. In the skin, both molecular variants reduce tumour development by 66% (p<0.01). In contrast, the liver and lung metastases are only significantly reduced by the soluble form (by 96%, p<0.002) whereas the membrane-bound variant exerts a barely significant effect in the liver (p = 0.049) and promotes tumour growth in the lungs. Moreover, we show a significant difference in the contribution of the infiltrating leukocytes to the tumour-suppressive activity of fractalkine between the standard and the orthotopic models. Conclusions: Fractalkine expression by C26 tumour cells drastically reduces their metastatic potential in the two physiological target organs. Both molecular forms contribute to its antitumour potential but exhibit differential effects on tumour development depending on the target tissue.
Calculation methods of transient processes in growing networks with non-linear preferential attachment rule

The problem of calculating transient processes in growing stochastic networks with non-linear preferential attachment rule is solved. Network growth dynamics equations are derived. Numerical methods for prompt calculation of transient processes in networks and specified network nodes are developed. The examples of the transient processes calculation are given. The proposed methods are confirmed by the results of simulation modeling. The use of developed methods allow to solve the problems of dynamic identification of the growing networks and regulation of the development processes.
A linearized polar transmitter for wireless applications

This paper reports on a new design method to overcome the nonlinear distortion associated to polar transmitters. The proposed methodology complements the modulation of drain bias, vDD(t), of conventional envelope elimination and restoration power amplifiers with a proper variation of the input drive level, vg(t). Allowing vg(t) to vanish when vDD(t) goes to zero, it obviates the inherent nonlinear distortion caused by the amplifier carrier feed-through. In addition, and beyond guaranteeing linear operation, such a design methodology is also beneficial for power added efficiency as it prevents the dissipation of instantaneous input power for a desired null instantaneous output power.
Inherently slow and weak forward forces of neuronal growth cones measured by a drift‐stabilized atomic force microscope

Previous results have shown that glial cells provide a soft environment for the neurons of the mammalian central nervous system (CNS). This raises the question whether neurons are confined to the CNS and cannot wander off into more rigid tissues, such as brain capillary walls. We investigated the mechanical properties and force generation of extending mouse retinal ganglion cells and NG108‐15 growth cones (GCs) using different atomic force microscope (AFM)‐based methods. For the first time, to our knowledge, we were able to measure the forward pushing forces at the leading edge of outgrowing neuronal GCs with our drift‐stabilized AFM. Our results demonstrate that these GCs have neither the required stability nor the ability to produce forces necessary to penetrate tissues that are at least an order of magnitude stiffer. © 2012 Wiley Periodicals, Inc.
Measurement of atmospheric refractivity using signals of opportunity

High-resolution numerical weather models require fine-scale (1-5 km) measurements of moisture fields over large areas (>;20,000 km2). Existing techniques such as GPS are not able to meet these requirements. This paper discusses the feasibility of a novel method for measuring atmospheric refractivity by the opportunistic reception and processing of digital radio and television signals. This technique is step towards the realization of a wide-area water vapor sensor network made possible by the widespread availability of digital broadcast signals. This paper presents the background and some preliminary results.