Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental study of effect of combining breviscapine with ischemic/preconditioning on the expression of myocardial protein tumor necrosis factor-α,nuclear factor-kappa B during myocardial ischemia/reperfusion in rabbits

Objective:This study is to observe the expression of protein Tumor necrosis factor-α (TNF-α) and nuclear factor-kappa B (NF-κB) during myocardial ischemia/reperfusion in new zealand rabbits in vivo and ap-proach preliminarily the function of breviscapine to myocardium in ischemic preconditioning.Method:Myocardial ischemia reperfusion models in new zealand rabbits in vivo were made and 36 rabbits were randomly divided into Group Sham (n=9),Group IR (ischemia/reperfusion group,n=9),Group IP (ischemic preconditioning group,n=9),and Group BI (Breviscapine+Ischemic preconditioning group,n=9). Each group was drewn blood samples to evaluation of CK and LDH.The area of myocardial infarct (AI) and the ischemic risk zone (AR) were determined by EB/TTC double staining,the expression of TNF-α and NF-κB protein were examined by immunohistochemical technique.Result:After reperfusion for 120 minutes,all of Group IR、IP and BI had apparent myocardial infarction compared with Group Sham (P0.01),and the myocardial infarct size (IS%) was decreased significantly in Group IP and Group BI compared with Group IR (P0.01) and decreased significantly in Group BI compared with Group IP (P0.05). Myocardial zymogram evaluation:both CK and LDH were increased obviously in Group IR,IP and BI compared with Group Sham (P0.01),and reduced in Group IP and Group BI compared with Group IR whenever (P0.01),and they two was decreased significantly in Group BI compared with Group IP (P0.05);The expression of TNF-α and NF-κB was increased obviously in Group IR,IP and BI (P0.01) compared with Group Sham,and decreased significantly in Group IP or Group BI compared with I/R (P0.01),and they were reduced in Group BI compared with Group IP (P0.05). Conclusion:Myocardial injury is induced during myocardial ischemia/reperfusion in rabbits.IPC or breviscapine with IPC reduces significantly infarct size and the myocardial enzymes,and decreases the expression of protein TNF-α and NF-κB. The mechanisms of their myocardial protections is probably related to reducing the inflammatory injury during myocardial ischemia/reperfusion.
Methicillin-Resistant Staphylococcus aureus Pneumonia: What is the Optimal Duration of Treatment?

BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) pneumonia is associated with high morbidity and mortality. There is no consensus about the length of therapy. Current Infectious Diseases Society of America consensus guidelines recommend 7 to 21 days for duration. MethodsIn a retrospective study conducted in a 900-bed teaching hospital in urban Detroit over a 26-month period, we evaluated the charts of 706 patients with positive MRSA respiratory cultures. We studied 115 patients with MRSA pneumonia. ResultsThe mean ± SD age for the patients was 64.36 ± 14.44 years; 67 patients (58.77 %) were women, 44 patients (38.26%) had multilobar pneumonia. Patients were treated with either vancomycin or linezolid or treatment was switched between those 2 agents. The mean ± SD treatment duration was 13.1 ± 7.1 days. The overall 28-day mortality rate was 28.73% (n = 32). Among the 83 patients who survived to 28 days, 9 patients (10.8%) received treatment for less than 8 days, 33 patients (39.8%) received treatment for 8 to 13 days, 26 patients (31.3%) received treatment for 14 to 20 days, and 15 patients (18.1%) received treatment for more than 20 days. Among the 32 patients who did not survive to 28 days, 11 patients (34.4%) received treatment for less than 8 days, 14 patients (43.8%) received treatment for 8 to 13 days, 6 patients (18.8%) received treatment for 14 to 20 days, and 1 patient (3.1%) received treatment for more than 20 days; P < 0.001. ConclusionThe nonsurvivors were treated for shorter durations than survivors, indicating that MRSA pneumonia requires longer treatment durations (≥14 days).
Clinical exam protocol for the equine thoracolumbar spine Protocolo de exame físico para a coluna toracolombar de equinos

Thoracolumbar injuries represent a challenge to the veterinarian that seeks to eliminate the pain, reinstitute the athletic use of the horse and minimize economic losses. The percentage of lost training days due to orthopedic conditions in race horses is of 72.1% and within those conditions is back pain, whicht represents from 4.35% to 20% of the lameness cases. The present study searched to establish a protocol based on score points for the thoracolumbar physical exam, by which it is able to determine the possible affected areas and the seriousness of the injuries. Along with the physical exam, it was performed an ultrasonographic exam of the thoracolumbar region to characterize and classify the injuries found, as to accompany its evolution after treatment. It was observed a clear reduction in the physical exam score sum in all animals between the exam days being that the exam of most of the animals presented a zero score at 60 days after the treatment. Relating the evolution of the clinical exam with the ultrasonography image tests, there was a positive association between the reduction score in the severity scale and the evolution of the ultrasonographic image of the evaluated structures. Thus, it can be concluded that gradation of the physical exam showed to be efficient and allowed the monitoring of the clinical evolution, as the answer of the injuries to the suggested treatment. Besides that, the results showed that 60 days is the ideal time for the first reevaluation of the animal after the treatment.
Apathy After Traumatic Brain Injury: An Overview of the Current State of Play

Abstract Apathy is a decrease in behavioural, cognitive and emotional components of goal-directed behaviour. Clinically, it is characterised by diminished initiation, reduced concern, and decreased activity. Apathy is a common occurrence following traumatic brain injury (TBI), occurring in around 60% of people. Consequences are widespread, negatively impacting independence, social integration, rehabilitation outcome, vocational outcome, coping and caregiver burden. The current knowledge base on apathy following TBI is presented, with implications for clinical practice. This includes a review of clinical presentations, neuroanatomical and neurochemical substrates associated with apathy, and differential diagnoses. Instruments to measure apathy are presented, highlighting those with demonstrated reliability and validity for the TBI population. Current evidence for pharmacological and non-pharmacological methods of treatment is described, with a model for non-pharmacological interventions provided and discussion of challenges faced by clinicians when treating the patient with apathy. In the TBI arena, greater understanding of apathy and methods of treatment is pivotal given the frequency of occurrence and widespread negative consequences.
Curative effect of Angelica Sini Decoction in the treatment of dysmenorrheal in 44 cases

Objective: To compare and analyse clinical effect of Angelica Sini Decoction on dysmenorrhea. Methods: Eighty-eight cases of dysmenorrhea patients in our hospital with clinical diagnosed were divided into two groups, each group of 44 cases. Group A were treated with norethisterone composite treatment; group B were treated with Angelica Sini Decoction. Clinical therapeutic efficacy, complications and adverse phenomenon, recurrence of comparative of patients in two groups were analyzed. Results: The analysis showed that clinical therapeutic effect of group B was obviously higher than that of group A, the efficiency many, the difference had a statistical significance (P0.05); the recurrence after treatment of group B was less than group A, the difference had statistical significance (P0.05); no serious complications and adverse phenomenon appeared in both groups, the difference had no statistical significance (P0.05). Conclusion: The effect of Angelica Sini Decoction on patients with dysmenorrhea is very obvious, the treatment is more thorough, it can make the patients get rid of illness distress in the shortest time, and does not cause special complications and adverse phenomenon, can be the preferred treatment for patients with dysmenorrhea.
A pilot feasibility study of a randomized controlled trial of goal setting using the values in action inventory of strengths following brain injury

ABSTRACT In a single-blind feasibility pilot randomized controlled trial design, brain injury (BI) participants were recruited from a community rehabilitation centre and randomized into goal-setting using the Values in Action Inventory of Strengths (VIA-IS), and goal-setting as usual. Outcomes included the feasibility and acceptability of the VIA-IS, and its use in setting goals in a BI rehabilitation context, and whether it affected types of goals set (International Classification of Functioning (ICF)). Memory for goals two weeks later was measured, and a sample size calculated for a full-scale trial. Twenty-six BI participants were recruited, and randomized to the VIA-IS (n = 13) and control group (n = 13). Two dropped out of the VIA-IS condition, leaving a total n = 24. The majority (92%) of participants rated the VIA-IS as acceptable; both groups described the goal-setting process as “easy”. VIA-IS feedback varied; over two thirds (73%) of VIA-IS participants used their VIA-IS results to set goals and described it as “helpful”. There were no major differences in ICF categories between groups. A sample size of 66 would be required for a full-scale trial. A full-scale trial with multi-centre design appears warranted though might be more clinically beneficial for difficult to engage BI clients.
Does Deliberative Education Increase Civic Competence? Results from a Field Experiment

Abstract How should education be structured to most effectively increase civic outcomes such as political knowledge and democratic values? We present results from a field experiment in which we compare the effects of deliberative education and traditional teacher-centered education. The study is the largest field experiment on deliberative education to date and involved more than 1,200 students in 59 classrooms. We test the effects on four forms of civic competence: political knowledge, political interest, democratic values, and political discussion. In contrast to previous research, we find little evidence that deliberative education significantly increases civic competence.
On the Dependence of Cirrus Parametrizations on the Cloud Origin

Parametrizations of Arctic cirrus particle size distributions are presented depending on the cloud origin, either in situ or liquid. The data set used originate from balloon‐borne measurements above Kiruna during winter. The observed particle size distributions are represented by gamma functions. The gamma coefficients exhibit large differences with regard to cloud origin. The functions for Arctic cirrus confirm established parametrizations for continental cirrus sorted by two particle size modes but differ from others depending only on temperature. We suppose that the agreement between the parametrizations of the geographically different cirrus is because in situ and liquid origin cirrus also distinguish by particle size modes. Since cloud sorting by their origin is based on physical processes which are independent of geographical region, we further hypothesize that these cloud‐type‐based parametrizations might be generally valid for use in global models and satellite retrievals, given the distribution of the cloud types is known.
Exploring the impact of The Students Assessing Teaching and Learning Program

The Students Assessing Teaching and Learning (SATAL) Program at the University of California, Merced offers assessment support for faculty and program leads while engaging diverse, cross-program undergraduates in students-as- partners experiences in a work setting. Grounded in the Students as Partners (SaP) principles of respect, responsibility, and reciprocity (Cook-Sather, Bovill, & Felten, 2014), our assessment of the SATAL program reveals benefits for both students and faculty acting as co-creators of teaching and learning. Using the SATAL program as an example, we offer readers a logic model to guide the development of student-faculty-staff partnerships and assess the impact of these programs in a more meaningful and consequential manner. We also provide lessons learned from our evolving SATAL program to support others interested in designing sustainable student assisted assessment partnerships.
The Role of Desire, Habit, and Temptation Resistance in the Relation between Trait Self-Control and Goal Success: A Study of Religious Goals in a Highly Religious Sample

ABSTRACT Trait self-control (TSC) is typically conceptualized as the ability to resist immediately gratifying (but problematic) impulses, and it predicts many positive life outcomes. Recent research, however, suggests that the benefits of TSC may operate not through effortful resistance of temptations, but rather, via good desires and habits. This “desires and habits” hypothesis has been supported in several goal-related domains, such as healthy eating, exercise, and homework. In the present study, we assessed if the hypothesis would be supported in the domain of religious goals. Participants included 166 committed Christians, who identified one religious practice (e.g., prayer) in which they wished to engage on a daily basis. On five days over a two-week period, participants reported experiences regarding desire, temptation resistance, and completion of their religious practice. As hypothesized, TSC predicted the successful completion of religious practices, and this relation was accounted for by good desires and habitual performance of the practice, but not by temptation resistance. Results were consistent with the hypothesis that “self-controlled” individuals may attain their goals not because they stop themselves from giving into temptations, but because their desires and habits are such that they experience fewer temptations to stray from their goals in the first place.
Obesity, metabolic syndrome and BMI-metabolic-risk sub-phenotypes: A study of an adult Nigerian population

Obesity and the metabolic syndrome are health care challenges of not only the industrialized nations but also of the developing countries. BMI-metabolic-risk sub-phenotypes separate obesity from its metabolic consequences. These indices have not been duly studied in Nigeria. One hundred and ninety nine adult Nigerians (52.3% females) were studied. Obesity and metabolic syndrome were defined using World Health Organization and US National Cholesterol Education Program Adult Treatment Panel III criteria, respectively. The presence or absence of the metabolic syndrome within the 3 BMI groups (normal, overweight and obese) was used to define 6 BMI-metabolic-risk sub-phenotypes. The results show that 12.1% (13.7% for males and 10.6% for females) of the population were obese. Metabolic syndrome was found in 30.8% (males 34.7%; females 26.9%) of the population. In the obese and overweight subjects, 33.3% and 40.9% respectively were metabolically healthy while 37.6% of the normal weight subjects were metabolically obese. BMI-metabolic-risk sub-phenotypes were found at the rates of 4%-34.2% in the entire population. The results are compared to figures from other studies, and discussed in the light of their implications for a country like Nigeria that is still battling with communicable diseases. Lifestyle modifications that encourage physical exertion and appropriate nutrition are advocated.
Bronchoscopic and Percutaneous Approaches to Lung Volume Reduction

Lung hyperinflation in chronic obstructive pulmonary disease is a major cause of breathlessness that responds poorly to medication. Lung volume reduction surgery provides relief of breathlessness, improved lung function, and exercise capacity and in some patients improves survival. However, it comes at a cost of surgical complications and mortality. Bronchoscopic lung volume reduction offers patients a less invasive and potentially safer alternative. This article reviews some of the techniques available and the most up-to-date evidence for them.
FAMILY NEEDS OF INCURABLE ILL CHILDREN IN THE CONTEXT OF SPECIAL EDUCATION

Incurable disease of children is one of the most difficult periods in the life of a family. The family must adapt to the new challenges that bring the illness and everything adapts to the needs of the child. However, we often don´t realize and even don´t know that the family needs must also be fulfilled. The paper presents partial results of the research aimed at identifying the needs of the family with an incurable ill child in a special pedagogical context. For the collection of research data a semi-structured interview with assistants working in the area of child palliative care was conducted. The obtained data were processed by qualitative analysis. The results point to the necessity of a transdisciplinary approach to children with incurable illness and their families – psychologist, social worker, clergymen, and special educator.
Knowledge sharing motivational factors among academic staff in Jordanian Private Universities

Numerous scholars and researchers have claimed that motivation can assist successful knowledge sharing among academic staff. Nonetheless, limited empirical research has been conducted to determine the individual and organizational factors that motivate the academics to share knowledge. Therefore, this study determined the individual and organizational factors that motivate the academics to share knowledge. Moreover, this study examined the relationship between knowledge sharing intention and knowledge sharing behaviour among the academics as well as the mediation effect of knowledge sharing intention on the relationship between individual and organizational factors and knowledge sharing behaviour. In this study, the individual factors were based on Lin model, whereas the organizational factors were based on Herzberg motivation theory. Convenience sampling was used to select 303 academic staff of Jordanian private universities to participate in the study. A cross-sectional survey was carried out using self-administered questionnaire. Exploratory factor analysis and Cronbach’s alpha tests using Statistical Package for Social Sciences software were conducted to ensure that the items were significantly valid and reliable. Average variance extracted and composite reliability were also examined to ensure all the constructs have good validity. Structural equation modeling was used to analyze the data. The main finding showed that individual and organizational factors are vital in motivating the academics for knowledge sharing. It was also found that there is a positive relationship between knowledge sharing intention and knowledge sharing behaviour among the staff. Furthermore, knowledge sharing intention was found to fully mediate the relationship between reciprocal benefits, knowledge self-efficacy, enjoyment in helping others, recognition, advancement, responsibility, achievement, university policy and administration, working conditions, interpersonal relations, quality of supervision and knowledge sharing behaviour. This study contributes to broadening the body of knowledge by determining that advancement, responsibility, achievement and interpersonal relation should be used to motivate academic staff for knowledge sharing. Universities must be more concerned on these factors as increasing academic staff’s willingness to share knowledge and awareness will lead to better university performance. In addition, universities should provide and implement practical plans and policies to recognize academics’ achievements and select a qualified leader to lead them for successful knowledge sharing.
“Needing different things from different people” – a qualitative exploration of recovery in first episode psychosis

ABSTRACT Social factors seem to play an important role in people’s recovery processes, yet little attention has been given to such aspects in relation to early psychosis. In this study, we explored how young adults with first episode psychosis experienced relationships inside and outside the mental healthcare services related to their early recovery processes. We interviewed ten young adults who had been in contact with an early detection team for psychosis. The analysis involved thematic and reflexive team-based methods and drew on hermeneutic–phenomenological perspectives. We identified two themes concerning relationships with professionals: 1) being seen as a unique person with preferences and 2) getting help when you are lost. We came across three additional themes, this time, in relation to family and friends: 3) supportive family networks, 4) they cannot understand everything, and 5) different kinds of friendships. Our findings revealed that people both within and outside mental healthcare services were seen as essential (for better or worse) and often played complementary roles.
A Comparison of User Preferences and Reported Compliance with the Bite Counter and the 24-Hour Dietary Recall

With two-thirds of the U.S. population being either overweight or obese, accurate tools for self-monitoring eating behaviors are needed for both research and personal purposes. To increase user compliance, these tools should be easy to use and impose a minimal burden on the user. The present study compares user preferences and compliance with the Bite Counter, a wrist-worn device designed to monitor eating behavior by counting bites, to the Internet-based Automated Self-Administered 24-hour dietary recall (ASA24). Eighty-three participants used the Bite Counter and the ASA24 for two weeks. At the end of the two-week period, participants were asked to rate their preference, compliance, and the ease of use for the two tools. 76% of the participants preferred the Bite Counter to the ASA24. Participants consistently used both tools. The Bite Counter was significantly easier to use, according to subjective ratings. These results indicate that users may be more likely to use the Bite Counter consistently than 24-hour dietary recalls.
The Self-Generated Stress Scale: Development, Psychometric Features, and Associations With Perfectionism, Self-Criticism, and Distress

In the current article, we describe the development and validation of a self-report measure of self-generated stress and its associations with measures of perfectionism, self-criticism, and distress. The Self-Generated Stress Scale is a seven-item inventory that taps the tendency to see oneself as someone who generates and adds to existing personal stress (i.e., making a challenging situation worse or turning a life problem into a bigger problem). Psychometric analyses with data from three samples of university students showed that the Self-Generated Stress Scale has one factor and acceptable internal consistency. Analyses established that self-generated stress is associated with trait perfectionism, self-criticism, dependency, and self-silencing, as well as indices tapping cognitive perfectionism and perfectionistic self-presentation. Self-generated stress was also associated with distress and psychosomatic health symptoms. Regression analyses established that scores on the Self-Generated Stress Scale predict unique variance in distress and negative affect beyond the variance attributable to self-criticism and other measures of stress. Overall, our findings attest to the further use of the Self-Generated Stress Scale in various contexts and highlight that certain perfectionists suffer from a perceived tendency to make their lives more stressful. The implications of these findings are discussed along with directions for future research.