Miracle-dz/UniFAR-FTUs huggingface dataset:
Defining a Service Delivery Platform Architecture by Reusing Intelligent Network Concepts

Telecommunication network operators and service developers need to develop and deliver a variety of single and multimedia based services to customers. To support these new customer services the underlying telecommunications infrastructure must provide various resources and capabilities that are reused in customer service development. These capabilities ensure customer service implementations are independent of the underlying infrastructure technologies and distribution mechanisms. In addition, these capabilities are offered to a variety of external customer service developers. To satisfy these requirements, the Service Delivery Platform (SDP) concept is proposed. The SDP is not standardised and current architectural representations are technology-specific. This paper contributes to the standardisation of the SDP by defining a technology independent SDP architecture. In our approach to define the architecture, we reuse concepts from the standardised Intelligent Network (IN). In this paper we define the SDP and its current architecture limitations. We also review the IN, its concepts and architecture. Based on both SDP requirements and IN we define a standardisable SDP architecture. Index Terms – Standardisation, Architecture, Intelligent Network, Service Delivery Platform.
Psychosocial correlates of premenstrual dysphoric subtypes

ABSTRACT— A modified version of the Premenstrual Assessment Form (PAF) was administered to 737 military wives as part of a study of stress and well being. A factor analysis of the responses suggests three main subtypes of premenstrual change — hostile depressive, atypical depressive, and anxious — as well as two minor subtypes — organic and hypomanic. Demographic and psychosocial correlates of factor scores are discussed.
Direct Stator Current Vector Control Strategy of DFIG Without Phase-Locked Loop During Network Unbalance

This paper proposes a direct stator current vector control strategy of a doubly fed induction generator (DFIG) without phase-locked loop (PLL) during network unbalance. In the proposed control strategy, a virtual phase angle produced by the nominal frequency is used for coordinate transformations instead of the actual voltage one estimated by the PLL. Since the calculation of the commanded stator currents is based on the instantaneous power theory regardless of the generator parameters, it can greatly reduce the parameter dependence of the control system. Then, for a satisfactory grid synchronization, an improved synchronization method is proposed. It can smoothly produce the stator voltage with no overshoot voltage and no parameter dependence. During network unbalance, a reduced-order vector integrator is used to directly regulate the pulsating components without the complex calculations of the commanded current values and the sequential separations of the voltages and currents. Meanwhile, four alternative control targets can be achieved for the DFIG during network unbalance. Furthermore, the control performance, including the control system stability, the robustness against frequency disturbances and parameter deviations, and the rejection of voltage unbalance, are fully analyzed. Finally, the experimental results are given to validate the effectiveness of the proposed control strategy.
Characterization of a Short Isoform of Human Tgs1 Hypermethylase Associating with Small Nucleolar Ribonucleoprotein Core Proteins and Produced by Limited Proteolytic Processing*

Tgs1 is the hypermethylase responsible for m3G cap formation of U small nuclear RNAs (U snRNAs) and small nucleolar RNAs (snoRNAs). In vertebrates, hypermethylation of snRNAs occurs in the cytoplasm, whereas this process takes place in the nucleus for snoRNAs. Accordingly, the hypermethylase is found in both compartments with a diffuse localization in the cytoplasm and a concentration in Cajal bodies in the nucleoplasm. In this study, we report that the Tgs1 hypermethylase exists as two species, a full-length cytoplasmic isoform and a shorter nuclear isoform of 65–70 kDa. The short isoform exhibits methyltransferase activity and associates with components of box C/D and H/ACA snoRNPs, pointing to a role of this isoform in hypermethylation of snoRNAs. We also show that production of the short Tgs1 isoform is inhibited by MG132, suggesting that it results from proteasomal limited processing of the full-length Tgs1 protein. Together, our results suggest that proteasome maturation constitutes a mechanism regulating Tgs1 function by generating Tgs1 species with different substrate specificities, subcellular localizations, and functions.
Visual Observation of PDMS Tip in Liquid Microcontact Printing

Microcontact printing has been shown to be a viable lithographic technique for the fabrication of microstructures, through the deposition of molecules by conformal contact between a surface and an elastomeric stamp. However, the diffusion of the molecules on the substrate and the deformation of the stamp during the contact are severe drawbacks when considering the resolution of the technique. In this paper, we show the effect of the diffusion of the molecules on the size of gold patterns on silicon and we observe in-situ the deformation of the PDMS stamp in liquid and air environment using an interferential microscopy technique.
Domain-domain interactions in obligate and non-obligate protein-protein interactions

In this study, an analysis of protein-protein interactions (PPIs) that uses properties of domain-domain interactions (DDIs) present in the interface is discussed. The aim is to predict obligate and non-obligate complexes. The results show that support vector machines (SVM) classifier achieves much better prediction performance, even better than linear dimensionality reduction (LDR) schemes and aslo desolvation energy is better than interface area and composition for predicting transient and obligate complexes. Moreover, a visual and numerical analysis insight of the distribution of the DDIs in different complexes is shown that most homo-domain pairs are in obligate interactions.
An Adaptive Penalty Scheme for Multiobjective Evolutionary Algorithm Based on Decomposition Shouyong Jiang and

The multiobjective evolutionary algorithm based on decomposition (MOEA/D) decomposes a multiobjective optimization problem into a number of sing-objective subproblems and solves them collaboratively. Since its introduction, MOEA/D has gained increasing research interest and has become a benchmark for validating new designed algorithms. Despite that, some recent studies have revealed that MOEA/D faces some difficulties to solve problems with complicated characteristics. In this paper, we study the influence the penalty-based boundary intersection (PBI) approach, one of the most popular decomposition approaches used in MOEA/D, on individuals’ convergence and diversity, showing that the fixed same penalty value for all the subproblems is not very sensible. Based on this observation, we propose to use adaptive penalty values to enhance the balance between population convergence and diversity. Experimental studies show that the proposed adaptive penalty scheme can generally improve the performance of the original PBI when solving the problems considered in this paper.
Performance limits of two-phase locking

A novel mean-value analysis method for two-phase locking (2PL) is presented which extends previous work to the important case of variable size transactions. The system performance expressed as the fraction of blocked transactions ( beta ) is determined by solving a cubic equation in beta whose coefficients are functions of a single parameter ( alpha ), which determines the degree of lock contention in the system. In fact, alpha is proportional to the mean number of lock requests per transaction ( eta /sub c/) and additionally the mean waiting time (W/sub 1/) for a lock held by an active transaction. For alpha < 0.226 the performance of the system is determined by the smallest root of the cubic and the system is thrashing otherwise, i.e. a large fraction of the transactions in the system are blocked. Validation of the analytic solution against simulation results shows that the analysis is quite accurate up to the point beyond which the system thrashes. It is shown that the variability of transaction size has a major effect on the degree of lock contention, since both eta /sub c/ and W/sub 1/ are affected by this distribution. A theoretical justification for Tay's rule of thumb that eta /sub c/ should be smaller than 0.7 to avoid thrashing is provided. It is shown that 2PL is susceptible to a cusp catastrophe. Sources of instability are identified, and methods for load control to avoid thrashing are suggested. <<ETX>>
Improve the problem of insufficient bandwidth and path congestion in the cloud computing environment by using self-adjustment scheduler

Users can effectively achieve the purpose of sharing hardware and software resources through the cloud computing. However, when the network load is too heavy or the network bandwidth is insufficient, the cloud computing often occupies a lot of network bandwidth. The operation delay makes the transmission performance decline rapidly. Therefore, the theme of this study focuses on the effective use of network resources to enhance the efficiency of the cloud computing environment. This study proposes a self-adjustment scheduler (SAS) that regulates the operation of the switch by detecting the traffic during the packet transmission. SAS is included by two mechanisms, the flow assignment (FA) and the flow weighted round robin (FWRR). With FA, when the delivering node is congested, the path table is quickly modified so that the next packet can be selected for alternate paths. Through this method, the path can be changed dynamically to deal with packet congestion. FWRR, taking into account the priority of data and the problem of preventing starvation, allows the bandwidth configuration to be dynamically adjusted to achieve fairness. Also, an experimental simulation established by using EstiNet network simulator to verify the SAS mechanism.
REPEATED SIGNIFICANCE TESTS OF A MULTI-PARAMETER IN SURVIVAL ANALYSIS

This paper illustrates a martingale method of constructing repeated sig- nificance tests for a multi-dimensional parameter in survival analysis by reducing it to tests for one-dimensional parameters. This illustration is made with parametric survival data with staggered entry. A simulation study is included to indicate its numerical performance. The purpose of this paper is to illustrate a martingale method of constructing repeated significance tests for a multi-dimensional parameter in survival analysis by reducing it to tests for one-dimensional parameters. We will make the illus- tration by considering parametric survival data with staggered entry times. The parameter space is assumed to be two-dimensional for simplicity, although it can be extended to higher dimensions without difficulty. For parametric survival data with staggered entry, we know the likelihood score process is a martingale relative to the calendar time filtration. In case the parameter space is one-dimensional, we can make a random time change to obtain a Brownian motion approximation to the likelihood score process, which paves the way to proposing repeated significance tests of the parameter. (cf. Andersen, Borgan, Gill and Keiding (1993), p.397). The situation is different in the multi-dimensional case. Although compo- nents of the likelihood score process are martingales, they are not orthogonal. The operating characteristics of sequential tests defined in terms of these like- lihood processes would be difficult to calculate. We will consider martingale transforms of these components so as to get orthogonal martingale estimating functions and then apply the strong representation theorem to obtain the stan- dard R 2 -valued Brownian motion approximation to them. With this preparation, we propose repeated significance tests and study their asymptotic properties. We would like to remark here that, although the model of Tsiatis, Boucher and Kim (1995) involves a multi-dimensional parameter, the hypothesis they
Optical resonators with Gaussian reflectivity mirrors: misalignment sensitivity.

An analytical solution to the problem of the misaligned optical resonator with a Gaussian reflectivity mirror is presented. It is shown that the fundamental mode of such a resonator remains a Gaussian beam which propagates along a tilted axis in the misalignment plane. The exact analytical solution yields simple expressions that characterize the misalignment sensitivity of the resonator by giving the beam-steering angle and the loss variations.
HUMAN COLOSTRAL AND BREAST MILK CELLS A Light and Electron Microscopic Study

Abstract. Colostrum and breast milk samples were obtained from 74 women, 18 of whom gave sequential samples. The mean total leukocyte count in colostrum was 3190 cells/mm3. Proportions of macrophages, polymorphs and lymphocytes varied widely; macrophages usually predominated. Serial sampling showed (1) a small fall in total counts through delivery, (2) a fall in total counts and the proportion of PMNs at the onset of lactation, (3) after 1 to 2 weeks of lactation the appearance of cytoplasmic fragments together with epithelial cells which later constituted the main cell type. It was estimated that the total number of leukocytes available to the neonate remained approximately constant during the first 2 weeks of lactation and fell thereafter. Functionally, morphologically and histochemically macrophages in colostrum and breast milk resembled macrophages elsewhere. Their ultrastructure was characterised by filiform surface projections, numerous endocytic vacuoles and lipid droplets in the cytoplasm.
Meat consumption and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population.

OBJECTIVE The association between meat consumption and colorectal cancer remains inconsistent among Asians. The present study systematically evaluated and meta-analyzed epidemiologic studies on the association between consumption of total and specific meats and colorectal cancer risk among Japanese. METHODS Original data were obtained from MEDLINE searched using PubMed or from searches of the Ichushi database, complemented with manual searches. The associations were evaluated based on the strength of evidence, the magnitude of association and biologic plausibility. A meta-analysis was performed according to total meat, red and processed meat as well as poultry and site-specific cancers. RESULTS Six cohort studies and 13 case-control studies were identified. In cohort studies, most investigations found no association between total meat consumption and colon/rectal cancer, and several studies showed a weak-to-moderate positive association of red meat and processed meat consumption with colon/rectal cancer. The majority of case-control studies showed no association between total meat consumption and colon and rectal cancer; however, several ones reported a weak-to-strong positive association of red and processed consumption with colon and rectal cancer. In meta-analysis, the summary relative risks (95% confidence interval) for the highest versus lowest categories of red meat consumption were 1.16 (1.001-1.34) and 1.21 (1.03-1.43) for colorectal and colon cancer, respectively, and those for processed meat consumption were 1.17 (1.02-1.35) and 1.23 (1.03-1.47) for colorectal and colon cancer, respectively. Poultry consumption was associated with lower risk of rectal cancer; summary relative risk (95% confidence interval) was 0.80 (0.67-0.96). CONCLUSIONS High consumption of red meat and processed meat possibly increases risk of colorectal cancer or colon cancer among the Japanese population.
The use of adipose-derived stem cells for the fabrication of three-dimensional spheroids for the osteogenic differentiation

Adipose-derived stem cells have been applied for the treatment of various diseases. This study was performed to fabricate the three-dimensional stem cell spheroids with adipose-derived stem cells and to evaluate the effects of cell number and culture duration on the viability and the osteogenic differentiation of three-dimensional cultures. Adipose-derived stem cells were purchased, and stem cell spheroids were formed using the silicon elastomer-based concave microwells in the amount of 1 × 105, 3 × 105, and 6 × 105. The morphology, the cell viability, and the osteogenic differentiation of stem cell spheroids were evaluated. Adipose-derived stem cells formed spheroids in the silicon elastomer-based concave microwells. A higher stem cell number led to spheroids with larger diameters. Most of the cells in the cell spheroids emitted green fluorescence. The relative Cell Counting Kit-8 showed that higher values were seen with higher stem cell numbers. The increase of alkaline phosphatase activity assays with longer incubation time in low dosage group and mineralized extracellular deposits were evenly noted in each group. This study clearly showed that adipose-derived stem cells formed spheroids in the silicon elastomer-based concave microwells and that osteogenic differentiation was achieved with higher activity and longer incubation time. Spheroid-based cell delivery could be used as a simple and effective strategy for stem cell therapy.
EXPERIMENTAL STUDY ON PERFORMANCE CHARACTERISTICS OF A PEM FUELCELL

The performance of a PEM fuel cell was investigated for different operating conditions. The fuel cell was tested for different dew point temperature of humidifier, the stack coolant temperature, and stoichiometric of fuel and air supply conditions. The higher stack coolant temperature, humidity, as well as stoichiometric of reactants produced enhanced performance of the fuel cell as expected. The effect on the cell voltage and efficiency were more pronounced as the current density was increased to medium and high levels. The deteriorating and degradation effect of the performance of the fuel cell was also observed during the test span.
Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p‐regulated transcription.

The GAL1‐10 genes of Saccharomyces cerevisiae are regulated by the interaction of cis‐ and trans‐acting factors which facilitate activated transcription in galactose but not in glucose medium. By selecting mutations that allow expression of a defective gal1‐10‐his3 hybrid promoter, we have identified a novel gene, NGG1, which is required for glucose repression of the GAL10‐related his3‐G25 promoter. ngg1 was identified as a recessive null mutation that in the presence of a gal80 background resulted in a 300‐fold relief of glucose repression for the his3‐G25 promoter. This compared with a 20‐fold and negligible relief of repression in gal80 and ngg1 strains, respectively. Deletion analysis of the his3‐G25 promoter showed a correlation between the number of GAL4p binding sites and the relative level of NGG1p activity. Relief of glucose repression by NGG1 was dependent on the presence of GAL4, but was independent of the GAL4 promoter. In addition, NGG1p activity was seen for a promoter construct containing independent GAL4p binding sites. These results suggest that NGG1p acts to inhibit GAL4p function in glucose medium. We have cloned NGG1 by complementation and found that it contains an open reading frame of 2106 bp which could encode a protein with a molecular weight of 79,230.
Inductive power transfer for Railway applications

Inductive power transfer (IPT) is used to transfer the power over relatively large air gap using the resonant phenomena. The use of IPT in the Railway transportations will enhance the system performance in terms of reducing the on board energy requirements, minimizing the visual pollution, and reducing the infrastructure. The main challenge in IPT is to transfer efficiently the power from the primary coil in the track to the secondary coil on the vehicles through the air. The presence of the air gap in the system will cause the efficiency to decrease. In this paper, the IPT for railway applications is addressed. The presented concept is validated through analysis and practical implementation.
A computer program based on parallel line assay for analysis of skin tests

A computer program for the analysis of differences or changes in skin sensitivity has been developed. It is based on parallel line assay, and its main features are its ability to conduct a validation process which ensures that the data from skin tests conform to the conditions imposed by the analysis which is carried out (regression, parallelism, etc.), the estimation of the difference or change in skin sensitivity, and the determination of the 95% and 99% confidence intervals of this estimation. This program is capable of managing data from independent groups, as well as paired data, and it may be applied to the comparison of allergen extracts, with the aim of determining their biologic activity, as well as to the analysis of changes in skin sensitivity appearing as a consequence of treatment such as immunotherapy.
Experimental investigation on the breakage in earth wire suspension string with winding preformed armor rods

Overhead earth wire breakage accident may occur frequently, which can seriously affect the reliable operation of the power grid. The main reason of the earth wire breakage is the contact resistance inside the clamp as short-circuit current flows through it. To understand the mechanism of the earth wire breakage, this paper conducts the theoretical study on the skin effect and contact resistance of the wire suspension string with winding preformed armor rods. The temperature rise experiments using of the new and old earth wire suspension string are performed to verify the theoretical analysis. The results show that the hotspots locate in the fracture of the preformed armor rods and the inside the clamp when short-circuit current flows through the earth wire suspension string. The reason could be the increase of the contact resistances in these two locations due to rust of the suspension string. Comparing with the earth wire suspension string without wrapping preformed armor rods, the number of hotspots in the earth wire may increase and accordingly the possibility of earth wire breakage can increase.
Alterations in the Two Globular Domains or in the Connecting α-Helix of Bacterial Ribosomal Protein L9 Induces +1 Frameshifts

ABSTRACT The ribosomal 50S subunit protein L9, encoded by the gene rplI, is an elongated protein with an α-helix connecting the N- and C-terminal globular domains. We isolated rplI mutants that suppress the +1 frameshift mutation hisC3072 in Salmonella enterica serovar Typhimurium. These mutants have amino acid substitutions in the N-terminal domain (G24D) or in the C-terminal domain (I94S, A102D, G126V, and F132S) of L9. In addition, different one-base deletions in rplI altered either the final portion of the C terminus or removed the C-terminal domain with or without the connecting α-helix. An alanine-to-proline substitution at position 59 (A59P), which breaks the α-helix between the globular domains, induced +1 frameshifting, suggesting that the geometrical relationship between the N and C domains is important to maintain the reading frame. Except for the alterations G126V in the C terminus and A59P in the connecting α-helix, our results confirm earlier results obtained by using the phage T4 gene 60-based system to monitor bypassing. The way rplI mutations suppress various frameshift mutations suggests that bypassing of many codons from several takeoff and landing sites occurred instead of a specific frameshift forward at overlapping codons.