Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiolabeled Gold Nanoseeds Decorated with Substance P Peptides: Synthesis, Characterization and In Vitro Evaluation in Glioblastoma Cellular Models

Despite some progress, the overall survival of patients with glioblastoma (GBM) remains extremely poor. In this context, there is a pressing need to develop innovative therapy strategies for GBM, namely those based on nanomedicine approaches. Towards this goal, we have focused on nanoparticles (AuNP-SP and AuNP-SPTyr8) with a small gold core (ca. 4 nm), carrying DOTA chelators and substance P (SP) peptides. These new SP-containing AuNPs were characterized by a variety of analytical techniques, including TEM and DLS measurements and UV-vis and CD spectroscopy, which proved their high in vitro stability and poor tendency to interact with plasma proteins. Their labeling with diagnostic and therapeutic radionuclides was efficiently performed by DOTA complexation with the trivalent radiometals 67Ga and 177Lu or by electrophilic radioiodination with 125I of the tyrosyl residue in AuNP-SPTyr8. Cellular studies of the resulting radiolabeled AuNPs in NKR1-positive GBM cells (U87, T98G and U373) have shown that the presence of the SP peptides has a crucial and positive impact on their internalization by the tumor cells. Consistently, 177Lu-AuNP-SPTyr8 showed more pronounced radiobiological effects in U373 cells when compared with the non-targeted congener 177Lu-AuNP-TDOTA, as assessed by cell viability and clonogenic assays and corroborated by Monte Carlo microdosimetry simulations.
Rancang Bangun Sistem Pemantauan Luaran Pico Generator pada Pembangkit Listrik Tenaga Bayu Sumbu Vertikal menggunakan Arduino UNO

Kebutuhan akan penggunaan energi listrik di dunia pada umumnya, di Indonesia pada khususnya terus meningkat seiring berjalannya waktu. Perbandingan antara jumlah penduduk yang sudah menikmati energi listrik dengan jumlah total penduduk yang ada di Indonesia disebut dengan rasio elektrifikasi. Salah satu upaya untuk memenuhi kebutuhan energi adalah menggunakan pembangkit listrik terbarukan yaitu pembangkit listrik tenaga bayu. Saat ini, Politeknik Negeri Batam memiliki turbin angin sumbu vertikal tipe savonius 3 blades yang berada di belakang gedung W7. Penelitian ini bertujuan untuk membuat sistem monitoring luaran pico generator menggunakan mikrokontroler arduino UNO secara real time dan membuat aplikasi berbasis komputer untuk menampilkan data hasil monitoring. Penelitian dilakukan dengan melakukan pengujian setiap komponen monitoring dan menggabungkan seluruh komponen tersebut menjadi sebuah sistem monitoring. Desain turbin pada penelitian mengalami perubahan, turbin angin yang digunakan yaitu turbin angin savonius dengan 6 blades. Hasil penelitian berupa data hasil monitoring dan aplikasi berbasis komputer untuk menampilkan data hasil monitoring. Monitoring dilakukan pada tanggal 11-17 Desember 2020. Rata-rata kecepatan angin yang ada di lingkungan Politeknik Negeri Batam yaitu 3.8 m/s. PLTB bekerja efektif untuk menghasilkan tegangan listrik selama 14.6 jam dalam satu minggu. Potensi daya angin maksimum yang dapat di ekstraksi oleh turbin angin sebesar 80.68 watt. Tegangan maksimum yang dapat dihasilkan oleh generator sebesar 1.1V. Tegangan luaran berbanding lurus dengan putaran generator, semakin besar putaran generator semakin besar tegangan yang dihasilkan.
Analysis of Thermal Effects for Polymer-Housed Metal-Oxide Surge Arrester Under Multiple Strokes

Multiple strokes are the main factors affecting the safe and stable operation of power equipment. As the core lightning protection equipment, arresters are also frequently thermally collapsed due to multiple strokes. This paper investigates thermal effects of polymer-housed metal-oxide surge arrester (PMOSA) under multiple strokes. The comparative experiments of PMOSA lightning impulse are carried out through multiple strokes of experiment platform, including continuous lightning stroke and multiple strokes. Furthermore, the temperature distribution of the housing surface is obtained by infrared imager for thermal effect analysis. Subsequently, some typical DC parameters are tested to explore the association of impulse aging and thermal effects of the arrester under multiple strokes. Finally, a thermal-electric coupling model (TECM) is constructed to investigate the influence of some factors on the temperature of PMOSA from the perspective of materials and structure. The research in this paper can provide a theory reference and brief data support for improving the heat dissipation performance of arresters under multiple strokes based on structural optimization design and material modification.
Influence of Factors Relating to Sex and Gender on Rank List Decisions and Perceptions of Residency Training: Survey Study

Background Females make up more than half of medical school matriculants but only one-third of emergency medicine (EM) residents. Various factors may contribute to why fewer females choose the field of EM, such as the existing presence of females in the specialty. Objective This study is a follow-up to previous work, and a survey is used to assess current residents’ attitudes and perceptions on various factors, including those relating to sex and gender on creating rank lists as medical students and in perceived effects on residency education. Methods A web-based survey consisting of Likert scale questions regarding a variety of factors influencing a student’s decision to create a rank list and in perceived effects on residency education was sent to current EM residents in 2020. Results Residents from 17 programs participated in the survey with an 18.2% (138/758) response rate. The most important factors in creating a rank list were the personality of residents in the program, location, and facility type. For factors specifically related to gender, respondents who answered affirmatively to whether the gender composition of residents affected the selection of a program in making a rank list were more likely to also answer affirmatively to subsequent questions related to the gender of program leadership (P<.001) and gender composition of attending physicians (P<.001). The personality of residents was also the most important factor perceived to affect residency education. For factors influencing rank list and residency education, female respondents placed higher importance on subcategories related to gender (ie, gender composition of the residents, of the program leadership, and of the attending physicians) to a significant degree compared with their male counterparts. Conclusions Although factors such as location and resident personality show the most importance in influencing residency selection, when stratifying based on respondent sex, females tend to indicate that factors relating to gender have more influence on rank list and residency education compared with males.
Unpacking effective mentorship practices for early career academics: a mixed-methods study

PurposeMentoring can be an important source of support, particularly for those who are in the early stages of their career in academia. Drawing upon data from a larger study, the authors investigated opportunities for mentorship, factors that hinder or support mentorship and the value of mentorship from the perspective of early career academics (ECAs). Design/methodology/approachUsing a mixed-methods approach and social identity theory, the authors collected data via a survey and follow-up interviews with members of staff at the Open University, of which 19 ECA experiences were contrasted with 17 academics who received mentorship but were not early career.FindingsECAs and non-ECAs had equal access to mentoring, but mentoring seemed to be more visible and accessible to ECAs. Factors deemed to support mentorship included mentors having empathy and confidentiality. Mentorship was valued by ECAs because it helped to provide them with support that was in addition to their line management and to help them make sense of “being an academic”. From the data presented, mentorship supported ECAs in their academic career and identity development in higher education.Originality/valueThis research provides a mixed-methods approach to investigating early career mentoring within the context of a higher education institution in the United Kingdom. It considers the topic of mentoring of both junior and more senior staff who are often working at a distance to the institutional setting and provides a theoretical perspective in terms of social identity for academics.
Etika Profesi Konselor dalam Layanan Bimbingan Konseling Virtual

The purpose of this study was to describe the professional ethics of counselors in virtual counseling guidance services. The method used in this research is a literature study with a qualitative descriptive approach. The data sources come from document studies in the form of books and previous research from various references. Furthermore, the data analysis technique used is descriptive analysis. The results of this study indicate that online counseling takes the form of virtual counseling technology, namely, websites, telephone or cell phones, email, video conferencing, chat, instant messaging, computers, and other social networks. The ethical aspects that must be obeyed by online counselors are building good relationships on the Internet, confidentiality when conducting consultations, legal aspects of telecommunications via the Internet, and licensing. Therefore, online counselors need to be professional in conducting virtual counseling by considering ethics.
Particle Filters for High Dimensional Spatial Systems

For example in a model of the low trophic level marine eco-system at the Bermuda Atlantic Timeseries (BATS) [3] site, that has 5 state variables resolved at 350 locations and 52 observations the filter distribution has 1 distinct point: A Solution: Particle smoothers are similar to particle filters except that they use observations available before and after the current time point in making their state estimates [5].
High-Yield Debt Covenants and Their Real Effects

: High-yield debt, including leveraged loans, is characterized by incurrence financial covenants, or “cov-lite” provisions. Unlike, traditional, maintenance covenants, incurrence covenants preserve equity control rights but trigger pre-specified restrictions on the borrower’s actions once the covenant threshold is crossed. We show that restricted actions impose significant constraints on investments: Similar to the effects of the shift of control rights to creditors in traditional loans, the drop in investment under incurrence covenants is large and sudden. This evidence suggests a new shock amplification mechanism through contractual restrictions that are at play for a highly levered corporate sector long before default or bankruptcy. our
Biochemical and Structural Analysis of a Glucose-Tolerant β-Glucosidase from the Hemicellulose-Degrading Thermoanaerobacterium saccharolyticum

β-Glucosidases (Bgls) convert cellobiose and other soluble cello-oligomers into glucose and play important roles in fundamental biological processes, providing energy sources in living organisms. Bgls are essential terminal enzymes of cellulose degradation systems and attractive targets for lignocellulose-based biotechnological applications. Characterization of novel Bgls is important for broadening our knowledge of this enzyme class and can provide insights into its further applications. In this study, we report the biochemical and structural analysis of a Bgl from the hemicellulose-degrading thermophilic anaerobe Thermoanaerobacterium saccharolyticum (TsaBgl). TsaBgl exhibited its maximum hydrolase activity on p-nitrophenyl-β-d-glucopyranoside at pH 6.0 and 55 °C. The crystal structure of TsaBgl showed a single (β/α)8 TIM-barrel fold, and a β8-α14 loop, which is located around the substrate-binding pocket entrance, showing a unique conformation compared with other structurally known Bgls. A Tris molecule inhibited enzyme activity and was bound to the active site of TsaBgl coordinated by the catalytic residues Glu163 (proton donor) and Glu351 (nucleophile). Titration experiments showed that TsaBgl belongs to the glucose-tolerant Bgl family. The gatekeeper site of TsaBgl is similar to those of other glucose-tolerant Bgls, whereas Trp323 and Leu170, which are involved in glucose tolerance, show a unique configuration. Our results therefore improve our knowledge about the Tris-mediated inhibition and glucose tolerance of Bgl family members, which is essential for their industrial application.
ANALYSIS OF THE EFFECT OF FINANCIAL RATIO ON FINANCIAL DISTRESS CONDITIONS IN MANUFACTURING COMPANIES LISTED IN INDONESIA STOCK EXCHANGE

This study aims to analyze any indicators in financial ratios that affect financial distress conditions. The data used are data on manufacturing companies in the Indonesia Stock Exchange (IDX) in 2012-2017, which are as many as 80 samples. Dependent financial distress variables are measured using the Altman analysis model (Z-Score). Independent variables are measured using the financial ratios indicator. This study uses a non-probability sampling technique that is purposive sampling. The data used is panel data, using Eviews 9. The results of this study show that the liquidity ratio measured by the current ratio and the leverage ratio measured by the debt asset ratio affect the condition of financial distress. While the profitability ratio measured by return on assets and sales growth does not affect the financial ratio. This research contributes to investors who can use this model, by including the financial ratios indicator, to assess the financial health of the company before making investment-related decisions.
Effect of Two Drying Methods on the Bioactive Cashew Apple Varieties Consumed in the City of Garoua (Northern Cameroon)

Aims: The cashew tree (family Anacardiaceae) grows widely in many parts of African countries, including Cameroon. Its fruit and nut are used for food and several studies have shown their beneficial effects on health. This work aimed to evaluate the impact of two drying methods on the content of bioactive compounds and antioxidant activity. Original Research Article Ghislain et al.; EJMP, 32(12): 64-77, 2021; Article no.EJMP. 77992 65 Methodology: Four varieties (VAR 1, VAR 2, VAR 3, VAR 4) of cashew apple samples were collected and drying using sun-dried and oven-dried to a constant weight, and then ground in a blender to a powder, the fresh one was cut up and crushed in a blender. All sample were reconstituted with distilled water and polyphenols, flavonoids, alkaloids contents, and antioxidant activity through different mechanisms (DPPH radical, FRAP and TAC assays) were assessed. Results: Alkaloids ranged from 1.50 mg EQui/g MF to 5.69 mg EQui/g DM for fresh and oven-dried VAR 1 respectively, polyphenols ranged from 786.15 mg EAG/g MF to 2836.92 mg EAG/g DM for fresh and oven-dried VAR 1 respectively, flavonoids ranged from 8.18 mg EAG/g MF to 295.45 mg EAG/g DM for fresh and oven-dried VAR 2 respectively. TAC values ranged from 13.09 mg EAA/g MF to 67.06 mg EAA/g for fresh and oven-dried VAR3 and VAR2 respectively. The highest DPPH radical scavenging value (86.25%) was obtained with fresh VAR 4 and the lowest (25.67%) with fresh VAR 1. The highest ferric reducing antioxidant power (FRAP) was obtained with fresh VAR 1 and VAR 3 (0.27 mg AAE/g MF) and the lowest with VAR 3 and VAR 4 oven-dried (0.23 mg AAE/g MF). Conclusion: In conclusion, the different cashew varieties studied in this work are a good source of antioxidants. The drying method significantly affects bioactive compounds and antioxidant activities. A weak but not significant correlation was obtained between the number of bioactive compounds and antioxidant activities.
Apoptosis effects of phenyl tagged isoxazole-benzoxadiazole hybrids On MDA MB-231 cancer cell line

In this report, a series of phenyl tagged isoxazole-benzoxadiazole hybrids 4a–4g were synthesized by substituting in phenyl ring C4’ with -OCH3, -CH3, -F, -Cl, -Br and C3’ with -NO2. Anticancer potential of 4a–4g on MDA MB-231 human cancer cell line was evaluated by using MTT assay. The order of anticancer activity of derived hybrids with phenyl ring substitution is, p-Br>p-Cl, p-F, m-NO2, p-CH3, >p-OCH3, parent hybrid. Among them, 4g; hybrid with p-Br exhibits highest anticancer behavior. The reported haptophoric hybrids may provide a useful insight for designing effective chemotherapy drugs for treating MDA MB 231 cancer cells.
Cloud Computing Adoption in the Higher Education (Sudan as a model): A SWOT Analysis

The use of cloud computing technology in higher education in the least developed countries represents a real opportunity for those countries. This study aims to perform SWOT analysis to determine the impact of the cloud computing implementation such as Strengths, Weaknesses, Opportunities and Threats (SWOT) in higher education institutions of the least developed countries, Republic of Sudan as model, and that from the perspective of Directors, Teachers and Students, to find the effect of strengths, weaknesses, opportunities and threats when using cloud computing technology in higher education. The study revealed positive results, because of the advantages offered by such as the flexibility and efficiency, and the ability to acquiring knowledge. There were drawbacks in the implementation of cloud computing such as privacy and security issues, and give this paper solutions to benefit from the opportunities, and to overcome the threats mentioned.
Computational approaches to lexical semantic change: Visualization systems and novel applications

The purpose of this chapter is to survey visualization and user interface solutions for understanding lexical semantic change as well as to survey a number of applications of techniques developed in computational analysis of lexical semantic change. We first overview approaches aiming to develop systems that support understanding semantic change in an interactive and visual way. It is generally accepted that computational techniques developed for analyzing and uncovering semantic change are beneficial to linguists, historians, sociologists, and practitioners in numerous related fields, especially within the humanities. However, quite a few non-professional users are equally interested in the histories of words. Developing interactive, visual, engaging, and easy-to-understand systems can help them to acquire relevant knowledge.
A Comparative Study of Nonlinear Control Schemes for Induction Motor Operation Improvement

In the objective of improving the performance of induction motor operation and ensuring a robust control against different uncertainties and external disturbances, especially at low-speed regions, this research highlights the main features of two nonlinear control techniques. First, the control design is based on the backstepping approach (BSA) with integral action, and then the sliding mode control (SMC) theory. The BSA principle is to define successive causal relations in order to construct the control law in a recursive and systematic way. This allows overcoming the obstacle of the higher-order system’s dimension. SMC is designed to drive and then constrain the system state to lie within a neighborhood of the switching surface, this provides very strong and inherent robustness to the resulting controllers. The main reason behind developing the nonlinear control techniques is to ensure a decoupled control of the machine. Besides, it guarantees the stability of the overall system by tracking the speed reference with the fewest static error. Moreover, as the sensorless control increases the reliability and decreases the cost of the control system, an extended Kalman filter is implemented to improve speed and flux observation. The simulations of all the discussed results have been obtained by MATLAB/Simulink.
MODELLING THE TEMPORAL EVOLUTION OF THE RETWEET GRAPH

Topological properties of graphs derived from social network platforms, like Twitter, give important insights on the nature of the social activities or on the way information spreads over the network. It may have also a relevant impact on designing new applications and improving already existing services. Different types of relations among the nodes define different graphs that can be analyzed, by tracking how relations evolve over time. Usually, this is performed in a cumulative way: once an edge is inserted, it is never deleted, see Leskovec et al. (2005) and Leskovec et al. (2010). However, the tweet life is limited, spanning from its birth to the very last retweet it receives. Therefore, we want to analyze the dynamics of evolutionary graphs, that is deleting tweets and thus edges among the nodes when they naturally expire as well as accounts that become therefore inactive. We introduce a variant of the retweet graph which takes into account the dynamics of Twitter users: Dynamic Retweet Graph (DRG) . In a DRG, once a tweet has been retweeted the last time all the edges representing this tweet are deleted, to model the decay of tweet life in the social platform. We analyze the characteristics of this graph using three different Twitter streams, built on three different contexts: two are event based (the 2015 Black Friday and the 2015 World Series), the third is the firehose of the whole Twitter stream, filtered by the Italian language. We use some standard social network analysis metrics to compare the structural properties of the DRG graph with cumulative evolving graphs.
Computer Aided Diagnosis for Pulmonary Embolism Nodule Detection

: Computer–aided detection and diagnosis systems have been adopted widely to improve the diagnosis performance by detecting and analyzing the lung diseases. The pulmonary embolism is considered as a fetal condition related to lung where the blood clot cause blockage to the lung arteries and this condition can cause death to the patient. Early detection of blood clot can help to diagnose the pulmonary embolism. In order to detect the PE, lung segmentation and nodule detection is the main task for any CAD system. Several approaches have been introduced to perform the segmentation but the accuracy and false positives of segmentation remains a challenging task in this field. Thus, we focus on the lung segmentation and nodule detection using computer vision approach for PE detection and developed Maximum Likelihood Probabilistic model for Pulmonary Embolism nodule detection (ML-PPED). According to the proposed approach, first of all we extract the lungs regions i.e. left and right lung regions followed by segmentation and finally a maximum likelihood based probabilistic model is developed to detect the lung nodules. The experimental analysis shows that the proposed approach improved the segmentation performance when compared with the existing techniques.