Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness and Comfort of Transcutaneous Electrical Nerve Stimulation for Older Persons with Chronic Pain

Background and Purpose: Transcutaneous electrical nerve stimulation (TENS) has been suggested for managing the pain of older persons. However, age‐related changes may limit TENS applicability. The purposes of this study were to: (1) determine the effectiveness and comfort of TENS during initiation of treatment for chronic pain in older persons, and (2) assess the influence of age on pain control and comfort of TENS. Methods: Sixteen assisted‐living residents (76.1±10.0 years old) with chronic musculoskeletal pain were divided into 2 groups (55‐75 and ≥76 years of age). Every 48 hours over one week, each of 3 treatments was randomly assigned: conventional, pulse‐burst and control (sham) TENS. Results: Age did not have a significant impact on pain (p=.576) or TENS comfort (p=.517). Conventional and pulse‐burst TENS did not differ in decreasing pain (p=.100); however, both were significantly different from control TENS (p=.050 and p=.010, respectively). Pain was decreased significantly (p<.001) for both conventional and pulse‐burst TENS, averaging 23% and 32% respectively. Control TENS produced only a 9% decrease in pain (p=.122). Conventional TENS was more comfortable than pulse‐burst TENS (p=.009). Conclusion: Based upon pain relief and comfort of TENS, treatment of older persons with chronic musculoskeletal pain should be initiated using conventional TENS.
Utilidad de los vehículos aéreos no tripulados en la búsqueda y triaje de personas en situaciones de catástrofe.

Objetivo: analizar la influencia del uso de un dron con camara termica en la localizacion y triaje de las victimas en una situacion de catastrofe. Metodo: en este estudio se realizaron 6 simulacros de busqueda de victimas y triaje (cada uno con 25 victimas). De manera aleatoria se hicieron dos grupos: Grupo Control (GC) y Grupo Dron (GD). Los profesionales del GD pudieron disponer de las imagenes de la camara termica instalada en un dron 10 minutos antes de comenzar el ejercicio. Resultados: La distancia media recorrida por el GC (1091.11 ± 146.41 m) fue mayor (t = -3.1468; p-valor = 0.003119) que la del GD (920 ± 71.93 m). El porcentaje medio de victimas encontradas por cada uno de los profesionales del GC (66.7 %) fue menor (X- squared = 13.1743; p-valor = 0.0001419) que las encontradas por cada uno de los profesionales del GD (92 %). En la calidad del triaje (infra y supratriaje), apertura de la via aerea y control de hemorragias no se han encontrado diferencias entre los dos grupos analizados. Conclusion: el uso de drones con camaras termicas ha sido util en la busqueda y localizacion de victimas en una situacion de catastrofe aunque no ha tenido impacto sobre la calidad del triaje realizado por los profesionales participantes en este estudio.
Galectin-3 and MCM2 expression in fine-needle aspiration cytology of thyroid nodules and their preoperative role in distinguishing benign from malignant thyroid lesions

Background Thyroid nodules are frequently seen in the general population. Preoperative discrimination between benign and malignant nodules is essential to avoid unnecessary surgery. Fine-needle aspiration cytology has greatly improved the clinical management of thyroid nodules. Follicular neoplasms, representing the indeterminate group by fine-needle aspiration cytology (FNAC), constitute a diagnostic problem. The aim of the study was to assess the diagnostic effect of galectin-3 and minichromosome maintenance protein2 (MCM2) expression in distinguishing benign from malignant thyroid nodules preoperatively. Patients and methods This was a prospective study that enrolled 79 patients who presented with thyroid enlargement and who were referred for fine-needle aspiration to the Cytology unit of Kasr Al-Aini Hospital, and the National Cancer Institute, between April 2008 and November 2009. Morphological and immunocytochemical analyses of FNA-derived cell block preparations were evaluated. Immunocytochemical assays using mouse monoclonal antibodies galectin-3 Ab-1 and MCM2 Ab-1 were performed preoperatively on follicular thyroid proliferations that were candidates for surgery, and their diagnostic accuracy was compared with the final histological findings. Results Sixty patients were included in the study and 19 were excluded (unsatisfactory results or lack of histological diagnosis). In this prospective study, FNAC, diffuse overexpression of galectin-3 and mean of MCM2 labeling index could discriminate benign from malignant thyroid lesions with sensitivities of 60, 90, and 66.7%, specificities of 100, 100, and 83.3%, and diagnostic accuracies of 80, 95, and 75%, respectively. Conclusion Galectin-3 expression is a very useful complementary marker for FNAC, increasing its sensitivity to detect malignant cases, especially if assessed semiquantitatively. The mean of MCM2 labeling index was higher in malignant thyroid lesions and it is a promising marker for future study, as high MCM2 scoring significantly suggests the lesion’s behavior.
Prediksi Penurunan Tanah Menggunakan Prosedur Observasi Asaoka Studi Kasus: Timbunan Di Bontang, Kalimantan Timur

Abstrak . Penurunan konsolidasi tanah merupakan masalah geoteknik yang sering ditemukan pada kasus timbunan, terutama pada tanah lunak. Penurunan konsolidasi disebabkan oleh keluarnya air pori dari dalam tanah yang disebabkan oleh peningkatan tegangan pada massa tanah. Untuk memprediksi besar penurunan serta lama waktu konsolidasi umumnya digunakan teori konsolidasi satu dimensi Terzaghi. Prediksi penurunan konsolidasi dengan teori ini, pada banyak kasus, memberikan hasil yang lebih besar dari penurunan aktual. Hal ini, salah satunya, disebabkan adanya pengabaian fenomena perkuatan tanah yang mungkin terjadi akibat proses penimbunan secara bertahap. Selain teori tersebut terdapat pula prediksi penurunan tanah dengan metode elemen hingga yang sudah menganalisis penurunan secara dua dimensi bahkan tiga dimensi. Namun untuk metode ini prediksi penurunan terhadap waktu, terutama untuk kasus perbaikan tanah dengan drainase vertikal, metode ini tidak memberikan hasil yang baik. Observasi Asaoka. Melalui prosedur ini, besarnya penurunan akhir dapat diprediksi dengan menggunakan data observasi penurunan akibat timbunan dengan menggunakan metoda curve fitting. Studi ini juga membahas perbandingan metode perhitungan penurunan dengan menggunakan teori konsolidasi Terzaghi, metode elemen hingga dan metode observasi Asaoka. Abstract . Consolidation settlement is a general geotechnical problem found embankment, particularly those founded on soft soil. Consolidation settlement is caused by the discharge of soil pore water induced by the increas of stress in soil mass. Terzaghi one dimensional theory was used to predict the settlement and time rate of consolidation. In many cases, the settlement prediction from this theory provides results much greater than the observed value due to many factors including the neglection of soil strength gain that may occur during consolidation process. In addition, there is also settlement prediction by using observed settlement data from the site using curve fitting method. This study presents settlement prediction method using Terzaghi consolidation theory, finite element method and Asaoka observational method.
Gastrointestinal Microflora in Radiation Injury and Countermeasure

Acute radiation syndrome (ARS) is a collection of pathological conditions as a result of exposure to high amounts of ionizing radiation (IR). Gastrointestinal (GI) system is highly sensitive to IR exposure and the symptoms include anorexia, nausea, vomiting and severe diarrhoea and can result in multiple organ failure. If remain untreated, it may result into death within 2 weeks with predominant cause being infection, dehydration and electrolyte imbalance. GI tract is inhabited by several commensal bacteria and damage to the GI system facilitates bacterial translocation to other organs due to loss in its integrity. Bacterial translocation results in conversion of commensals into opportunistic pathogens which secrete variety of lethal toxins culminating in multiple organ failure. Present review focuses on elucidating consequences of radiation exposure to GI system, the microbiota inhibiting GI and critical analysis of data from different studies done so far to counter those consequences. Using traditional therapeutics, there are no promising measures developed so far, to counter such radiation emergency to an acceptable extent. Review of existing literature urges development of innovative countermeasures and fecal transplant. Review Article Kainthola et al.; ARRB, 10(1): 1-22, 2016; Article no.ARRB. 24690 2
Estimação de parâmetros genéticos para características de crescimento de ovinos Santa Inês utilizando modelos uni e multicaracterísticas

Records of birth weights at 196 days of age of 927 lamb progenies of 45 sires and 323 dams of Santa Ines sheep, controlled from 1983 to 2000, were used with purpose of evaluating three models that considered or no the maternal genetic effect and covariance between direct and maternal genetic effects, to estimate variance components and genetic parameters by single and two-trait analyses. The (co)variance components and genetic direct and maternal parameters were estimated by restricted maximum likelihood methods, under animal model. The model that included additive direct and maternal effects showed higher value for log likelihood for all the studied traits. Model without maternal effect overestimated the variances and heritability for direct genetic effect (0.56 to 0.23). The importance of maternal effect decreased with growth, as the age of the lambs increased. The variances and heritability estimates in two-trait models for genetic direct genetic effect were higher than those obtained by single-trait models. The genetic correlations between the traits were high and positive. The maternal effect was important for all the studied traits. The two-trait models allowed better estimate of the direct additive variance, causing higher heritability value.
Eponyms in dermatology literature linked to Sweden

Sweden is the third largest country in the European Union by area, with a total population of about 9.4 million [1]. There are several medical eponyms originated from this country. In Table I [2-8] we listed selected eponyms in dermatology literature linked to Sweden. The Online Wikipedia, referred to interesting facts about the scientific advancement of this country. Sweden tops other European countries in the number of published scientific works per capita. It ranks in the top five countries with respect to low infant mortality. It also ranks high in life expectancy [1]. Swedish inventors hold a total of 33,523 patents in the United States as of 2007, according to the United States Patent and Trademark Office. As a nation, only ten other countries hold more patents than Sweden [1]. The Nobel Prize is well-known all over the world. It is instituted by Alfred Bernhard Nobel (1833-1896) (Fig.1), who was a Swedish chemist, engineer, innovator, and armaments manufacturer. He was the inventor of dynamite. Dermatologists around the world is also remembering Sweden for, Acta Dermato-Venereologica, which is an international peer-review journal for clinical and experimental research in the field of dermatology and venereology published in Sweden since 1920. EPONYMS IN DERMATOLOGY LITERATURE LINKED TO SWEDEN
STUDY OF SHORELINE CHANGES AT JENEBERANG RIVER DELTA, MAKASSAR

The study of shoreline changes during 1990 - 2008 in the delta of the River Jeneberang, Makassar was conducted by evaluating sediment transport into and out of a cell. Longshore sediment transport was computed by considering the influence of heights and angles of the breaking waves. Results of calculation of sediment transport showed that the dominant of sediment transport was to the north during the arrival of the southwest and west waves, and to the south when the wave coming from the northwest. Comparison between shore profiles resulting from model and coastline satellite imagery showed similarity. The difference between the two tend to be occurred at the head land part of the shoreline. This was due to complexity of coastal dynamic at the area. The results of the 19 years shoreline simulation showed that there was a tendency of abrasion at the upsteam head land part as the wave energy tend to converge and accretion at the bay part as the wave energy tend to diverge. Abrasion mainly occurred at Tanjung Bunga (head land) where the coast retreat 181.1 m. Accretion occur in the bay area (Tanjung Merdeka) where the coast advance to the sea for about 59.8 m. The shoreline tend to be stable when the profile was straight such as Barombong Coast. Keywords: abrasion, accretion, sediment transport, shoreline changes.
Studies of South American plants, XVI

ONE OF THE MOST SIGNIFICANT ACQUISITIONS Of the U. S. National Museum in the botanical field in recent years has been the large collection of plants assembled by more than twenty botanists in South America, during World War II, under the auspices of various U. S. Government Cinchona Missions. These collections were brought together and prepared for study by Dr. W. A. Archer, of the U. S. National Arboretum, and they are now deposited in the U. S. National Herbarium (indicated herein as US). In the present paper seven new species of the families Monimiaceae and Vacciniaceae are described and various other noteworthy plants of the latter family are discussed. The collections mentioned in this paper have principally been made by Messrs. E. L. Core, W. B. Drew, J. A. Ewan, N. C. Fassett, F. R. Fosberg, M. L. Grant, and E. L. Little. These individuals and their associates are to be complimented upon the excellence of their specimens, obtained in little-known regions and often under great difficulties.
Survival analysis of female dogs with mammary tumors after mastectomy : epidemiological , clinical and morphological aspects 1

Dias M.L. M. , Andrade J.M.L. , Castro M.B. & Galera P.D. 2016. Survival analysis of female dogs with mammary tumors after mastectomy: epidemiological, clinical and morphological aspects. Pesquisa Veterinária Brasileira 36(3):181-186. Departamento de Cirurgia de Pequenos Animais, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Avenida L4 Norte, Asa Norte, Brasília, DF 95320-000, Brazil. E-mail: dra.paulagalera@gmail.com Mammary gland tumors are the most common type of tumors in bitches but research on survival time after diagnosis is scarce. The purpose of this study was to investigate the relationship between survival time after mastectomy and a number of clinical and morphological variables. Data was collected retrospectively on bitches with mammary tumors seen at the Small Animal Surgery Clinic Service at the University of Brasília. All subjects had undergone mastectomy. Survival analysis was conducted using Cox’s proportional hazard method. Of the 139 subjects analyzed, 68 died and 71 survived until the end of the study (64 months). Mean age was 11.76 years (SD=2.71), 53.84% were small dogs. 76.92% of the tumors were malignant, and 65.73% had both thoracic and inguinal glands affected. Survival time in months was associated with age (hazard rate ratios [HRR] =1.23, p-value =1.4x10-4), animal size (HRR between giant and small animals =2.61, p-value =0.02), nodule size (HRR =1.09, p-value =0.03), histological type (HRR between solid carcinoma and carcinoma in a mixed tumor =2.40, p-value =0.02), time between diagnosis and surgery (TDS, with HRR =1.21, p-value =2.7x10-15), and the interaction TDS*follow-up time (HRR =0.98, p-value =1.6x10-11). The present study is one of the few on the subject matter. Several important covariates were evaluated and age, animal size, nodule size, histological type, TDS and TDS*follow up time were identified as significantly associated to survival time.
Patients' Perspective of Treatment in Eating Disorders: A Preliminary Study

The patient's perspective of treatment is seldom considered when psychological interventions are evaluated. Our aim was to undertake a qualitative study to assess the patients' viewpoint of what was helpful as well as harmful about the treatment they have completed. Twenty-one female referrals to an outpatient university-based eating disorders service (10 anorexia nervosa and 11 bulimia nervosa, mean age = 24.7 years, SD = 9.8) were interviewed on average one year after completion of either family counselling or cognitive-behavioural treatment. Most patients reported improvements as a result of treatment, although our formal assessment was more cautious. Patients identified psychoeducation, a supportive environment, challenging of dysfunctional beliefs, and behavioural strategies as helpful components of treatment. A significant minority felt that causes of the illness were dealt with inadequately, and that behavioural strategies were insufficient when symptoms were too overpowering. This study shows that gaining the patient's perspective of therapy could provide clinicians with helpful feedback to improve treatment for this challenging patient population.
Case marking and word order in Greek heritage children

Abstract This study examined the linguistic and individual-level factors that render case marking a vulnerable domain in English-dominant Greek heritage children. We also investigated whether heritage language (HL) children can use case-marking cues to interpret (non-)canonical sentences in Greek similarly to their monolingual peers. A group of six- to twelve-year-old Greek heritage children in New York City and a control group of age-matched monolingual children living in Greece participated in a production and a picture verification task targeting case marking and (non-)canonical word order in Greek. HL children produced syncretic inflectional errors, also found in preschool monolingual children. In the comprehension task, HL children showed variable performance on the non-canonical OVS but ceiling performance on the SVO conditions, which suggests influence from English. Linguistic factors such as case transparency affected comprehension, whereas child-level factors such as proficiency and degree of (early) use of Greek influenced performance on both modalities.
Biomarkers of sarcopenia in very old patients with hip fracture

Hip fracture is both a cause and a consequence of sarcopenia. Older persons with sarcopenia have an increased risk of falling, and the prevalence of sarcopenia may be increased in those who suffer a hip fracture. The aim of this study was to explore potential biomarkers (neuromuscular and peripheral pro‐inflammatory and oxidative stress markers) that may be associated with sarcopenia in very old persons with hip fracture.
High-Performance Ultraviolet Light-Emitting Diodes Using n-ZnO/p-hBN/p-GaN Contact Heterojunctions.

Effective ultraviolet light-emitting diodes (LEDs) were fabricated by clamping the n-ZnO films on the top of p-hBN/p-GaN/sapphire substrates. An ultraviolet emission originating from ZnO was measured from the diode under forward bias, the electroluminescence (EL) spectra of which show a peak wavelength of ~376 nm with a narrow full-width at half maximum of ~12 nm. Compared with the reference diode fabricated by directly growing n-ZnO on the p-hBN substrates using metal-organic chemical vapor deposition, the proposed diode showed a dramatic increment of the EL intensity, meanwhile its emission onset lowered down considerably. The improved optical property of the proposed LED is mainly ascribed to suppressing the formation of the BNO-related layer at the n-ZnO/p-hBN interface. The present work provides a simple and feasible approach for developing advanced ZnO-based optoelectronic devices.
Discussions of miscarriage and preterm births on Twitter

Abstract Background Experiences typically considered private, such as, miscarriages and preterm births are being discussed publicly on social media and Internet discussion websites. These data can provide timely illustrations of how individuals discuss miscarriages and preterm births, as well as insights into the wellbeing of women who have experienced a miscarriage. Objectives To characterise how users discuss the topic of miscarriage and preterm births on Twitter, analyse trends and drivers, and describe the perceived emotional state of women who have experienced a miscarriage. Methods We obtained 291 443 Twitter postings on miscarriages and preterm births from January 2017 through December 2018. Latent Dirichlet Allocation (LDA) was used to identify major topics of discussion. We applied time series decomposition methods to assess temporal trends and identify major drivers of discussion. Furthermore, four coders labelled the emotional content of 7282 personal miscarriage disclosure tweets into the following non‐mutually exclusive categories: grief/sadness/depression, anger, relief, isolation, annoyance, and neutral. Results Topics in our data fell into eight groups: celebrity disclosures, Michelle Obama's disclosure, politics, healthcare, preterm births, loss and anxiety, flu vaccine and ectopic pregnancies. Political discussions around miscarriages were largely due to a misunderstanding between abortions and miscarriages. Grief and annoyance were the most commonly expressed emotions within the miscarriage self‐disclosures; 50.6% (95% confidence interval [CI] 49.1, 52.2) and 16.2% (95% CI 15.2, 17.3). Postings increased with celebrity disclosures, pharmacists’ refusal of prescribed medications and outrage over the high rate of preterm births in the United States. Miscarriage disclosures by celebrities also led to disclosures by women who had similar experiences. Conclusions This study suggests that increase in discussions of miscarriage on social media are associated with several factors, including celebrity disclosures. Additionally, there is a misunderstanding of the potential physical, emotional and psychological impacts on individuals who lose a pregnancy due to a miscarriage.
BEM: Mining Coregulation Patterns in Transcriptomics via Boolean Matrix Factorization

MOTIVATION The matrix factorization is an important way to analyze co-regulation patterns in transcriptomic data, which can reveal the tumor signal perturbation status and subtype classification. However, current matrix factorization methods do not provide clear bicluster structure. Furthermore, these algorithms are based on the assumption of linear combination, which may not be sufficient to capture the coregulation patterns. RESULTS We presented a new algorithm for Boolean matrix factorization via expectation maximization (BEM). BEM is more aligned with the molecular mechanism of transcriptomic coregulation and can scale to matrix with over 100 million data points. Synthetic experiments showed that BEM outperformed other Boolean matrix factorization methods in terms of reconstruction error. Real world application demonstrated that BEM is applicable to all kinds of transcriptomic data, including bulk RNAseq, single cell RNAseq, and spatial transcriptomic datasets. Given appropriate binarization, BEM was able to extract coregulation patterns consistent with disease subtypes, cell types, or spatial anatomy. AVAILABILITY Python source code of BEM is available on https://github.com/LifanLiang/EM_BMF. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.