Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48)

BLAST-1 (CD48) (previously referred to as BCM-1 by the Human Gene Nomenclature Committee) is an early-activation-associated membrane glycoprotein expressed on the surface of human leukocytes and induced to a high level following infection of B cells by the Epstein-Barr virus. It is a member of the immunoglobulin superfamily, mediates cell adhesion, and has significant sequence homology to two other adhesion molecules, CD2 and LFA3. Here we report the isolation and characterization of the BLAST-1 gene. The gene is at least 28.6 kb in length, is split into 4 exons, and contains a restriction fragment-length polymorphism. The overall genomic organization is consistent with other members of the immunoglobulin superfamily, in which extracellular immunoglobulinlike domains are encoded by discrete exons. Transcription is initiated at a series of major and minor sites in both normal and tumor-derived lymphoid cells. Appropriately located TATA and CCAAT box sequences were not detected. These characteristics have also been demonstrated for the recently described B-cell-specific genes B29 and CD20. The expression of these genes in B cells may involve the use of multiple promoters and novel transcription initiator-binding proteins. A 1.58-kb genomic DNA fragment, consisting of the 5'-flanking region located immediately upstream of the ATG initiation codon, was able to drive the expression of a reporter gene in an orientation-dependent and tissue-restricted manner.
The Detection and Tracking of Weak Frequency Line Based on Double-detection Algorithm

The paper aims to deal with the problem of automatic detection of narrow-band signals which is encountered in a passive sonar system. The double-detection algorithm at low signal-to-noise ratio is put forward on a basis of double-thresholds detection, and realizes the intelligence methods of frequency line detection and tracking. It makes frequency line detection and tracking more intelligent. The results of experimental data processing reveal that this method can increase the possibility of weak frequency line detection and tracking, and decrease the false alarm rate.
Efficacy and Safety of Long‐Term Treatment With the Combination of Amlodipine Besylate and Olmesartan Medoxomil in Patients With Hypertension

The authors report on the 44‐week open‐label extension of the 8‐week, double‐blind Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial in 1684 patients. Initial therapy was amlodipine (AML) plus olmesartan medoxomil (OM) 5+40 mg/d, up‐titrated to AML+OM 10+40 mg/d plus hydrochlorothiazide (HCTZ) 12.5 mg then 25 mg if patients did not achieve blood pressure (BP) goal (<140/90 mm Hg or <130/80 mm Hg in patients with diabetes). Baseline mean BP decreased from 164/102 mm Hg to 131/82 mm Hg at end of study, with an overall 66.7% of patients, including those with diabetes, achieving BP goal. The BP goal achievement was 80% for AML+OM 5+40 mg/d, 70.6% for AML+OM 10+40 mg/d, 66.6% for AML+OM+HCTZ 10+40+12.5 mg/d, and 46.3% for AML+OM+HCTZ 10+40+25 mg/d. Study medication was safe and well tolerated. Combination antihypertensive therapy with AML+OM±HTCZ, up‐titrated as necessary, allowed a majority of patients to achieve BP goal.
Photodynamic therapy in dermatology: state‐of‐the‐art

Photodynamic therapy (PDT) has become an established treatment modality for dermatooncologic conditions like actinic keratosis, Bowen's disease, in situ squamous cell carcinoma and superficial basal cell carcinoma. There is also great promise of PDT for many non‐neoplastic dermatological diseases like localized scleroderma, acne vulgaris, granuloma anulare and leishmaniasis. Aesthetic indications like photo‐aged skin or sebaceous gland hyperplasia complete the range of applications. Major advantages of PDT are the low level of invasiveness and the excellent cosmetic results. Here, we review the principal mechanism of action, the current developments in the field of photosensitizers and light sources, practical aspects of topical PDT and therapeutical applications in oncologic as well as non‐oncologic indications.
Diagnostic value of voice acoustic analysis in assessment of occupational voice pathologies in teachers

It has been shown that teachers are at risk of developing occupational dysphonia, which accounts for over 25% of all occupational diseases diagnosed in Poland. The most frequently used method of diagnosing voice diseases is videostroboscopy. However, to facilitate objective evaluation of voice efficiency as well as medical certification of occupational voice disorders, it is crucial to implement quantitative methods of voice assessment, particularly voice acoustic analysis. The aim of the study was to assess the results of acoustic analysis in 66 female teachers (aged 40–64 years), including 35 subjects with occupational voice pathologies (e.g., vocal nodules) and 31 subjects with functional dysphonia. The acoustic analysis was performed using the IRIS software, before and after a 30-minute vocal loading test. All participants were subjected also to laryngological and videostroboscopic examinations. After the vocal effort, the acoustic parameters displayed statistically significant abnormalities, mostly lowered fundamental frequency (Fo) and incorrect values of shimmer and noise to harmonic ratio. To conclude, quantitative voice acoustic analysis using the IRIS software seems to be an effective complement to voice examinations, which is particularly helpful in diagnosing occupational dysphonia.
Emotion Contagion among Affective Agents - Issues and Discussion

Emotional contagion is a mechanism which results in transferring an emotion from one person to another; in fact, it has been proven to be one of the key factors in successful crowd managing and preserving an amiable working atmosphere. However, believable simulation of a group of people with social links amongst them requires not only complex interaction models but also complex internal models as well. This paper describes the progress of an on-going research that explores and simulates various types of emotions while they are being transmitted amongst affective intelligent agents that are connected in simulated social structure. The internal mechanism of agents is based on affective agent architectures while the contagion and its rules are being modelled by using tools from graph theory.
EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1

ABSTRACT Cyclic AMP (cAMP) activates protein kinase A (PKA) but also the guanine nucleotide exchange factor ‘exchange protein directly activated by cAMP’ (EPAC1; also known as RAPGEF3). Although phosphorylation by PKA is known to regulate CFTR channel gating – the protein defective in cystic fibrosis – the contribution of EPAC1 to CFTR regulation remains largely undefined. Here, we demonstrate that in human airway epithelial cells, cAMP signaling through EPAC1 promotes CFTR stabilization at the plasma membrane by attenuating its endocytosis, independently of PKA activation. EPAC1 and CFTR colocalize and interact through protein adaptor NHERF1 (also known as SLC9A3R1). This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1. Our findings identify a new CFTR-interacting protein and demonstrate that cAMP activates CFTR through two different but complementary pathways – the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1. The latter might constitute a novel therapeutic target for treatment of cystic fibrosis. Summary: Activation of the cAMP sensor EPAC1 leads to stabilization of CFTR at the plasma membrane, through a mechanism that involves the PDZ adaptor NHERF1, and could be used to increase the rescue of mutant CFTR.
Disabled-2 (Dab2) Is Required for Transforming Growth Factor β-induced Epithelial to Mesenchymal Transition (EMT)*

Transforming growth factor β (TGFβ) induces an epithelial to mesenchymal transition (EMT) during both physiological and pathological processes; however, the mechanism underlying this transition is not fully elucidated. Here, we have demonstrated that TGFβ induces the expression of the adaptor molecule disabled-2 (Dab2) concomitant with the promotion of EMT. We show that TGFβ induces a transient accumulation of Dab2 to the membrane and increases Dab2 binding to β1 integrin. Furthermore, small interfering RNA (siRNA)-mediated silencing of Dab2 expression in mouse mammary gland epithelial cells results in inhibition of integrin activation, shown by a decrease of both TGFβ-induced focal adhesion kinase phosphorylation and cellular adherence, leading to apoptosis and inhibition of EMT. Forced re-expression of human Dab2, not targeted by the mouse siRNA sequence, rescues cells from apoptosis and restores TGFβ-mediated integrin activation and EMT. These results are confirmed in the F9 teratocarcinoma cell line, a model for retinoic acid-induced visceral endoderm differentiation in which we demonstrate that ablation of retinoic acid-induced Dab2 expression levels, by stable siRNA silencing of Dab2, blocks visceral endoderm differentiation. Our findings indicate that Dab2 plays an important regulatory role during cellular differentiation and that induction of differentiation in the absence of Dab2 expression commits the cell to apoptosis.
Development and Validation of Search Filters to Identify Articles on Family Medicine in Online Medical Databases

Physicians and researchers in the field of family medicine often need to find relevant articles in online medical databases for a variety of reasons. Because a search filter may help improve the efficiency and quality of such searches, we aimed to develop and validate search filters to identify research studies of relevance to family medicine. Using a new and objective method for search filter development, we developed and validated 2 search filters for family medicine. The sensitive filter had a sensitivity of 96.8% and a specificity of 74.9%. The specific filter had a specificity of 97.4% and a sensitivity of 90.3%. Our new filters should aid literature searches in the family medicine field. The sensitive filter may help researchers conducting systematic reviews, whereas the specific filter may help family physicians find answers to clinical questions at the point of care when time is limited.
Adaptive Synchronization of Chaotic Systems via State or output Feedback Control

This letter addresses the problem of robust adaptive control for synchronization of continuous-time coupled chaotic systems, which may be subjected to disturbances. A general model is studied via two different approaches, using either state feedback or measured output feedback controls. Adaptive controllers are designed, in which a sliding mode structure is employed to increase the robustness of the closed-loop systems. When only output variables are measurable for synchronization, the adaptive controllers are designed by incorporating with a filter and using the so-called σ-modification technique. Several numerical examples are presented to show the effectiveness of the proposed chaos synchronization methods.
Linear and nonlinear features of fetal heart rate on the assessment of fetal development in the course of pregnancy and the impact of fetal gender

Objective: This work aims to investigate the impact of gestational age and fetal gender on fetal heart rate (FHR) tracings. Approach: Different linear and nonlinear parameters indicating correlation or complexity were used to study the influence of fetal age and gender on FHR tracings. The signals were recorded from 99 normal pregnant women in a singleton pregnancy at gestational ages from 28 to 40 weeks, before the onset of labor. There were 56 female fetuses and 43 male. Main results: Analysis of FHR shows that the means as well as measures of irregularity of FHR, such as approximate entropy and algorithmic complexity, decrease as gestation progresses. There were also indications that mutual information and multiscale entropy were lower in male fetuses in early pregnancy. Significance: Fetal age and gender seem to influence FHR tracings. Taking this into consideration would improve the interpretation of FHR monitoring.
Mental healthcare staff well‐being and burnout: A narrative review of trends, causes, implications, and recommendations for future interventions

Rising levels of burnout and poor well-being in healthcare staff are an international concern for health systems. The need to improve well-being and reduce burnout has long been acknowledged, but few interventions target mental healthcare staff, and minimal improvements have been seen in services. This review aimed to examine the problem of burnout and well-being in mental healthcare staff and to present recommendations for future research and interventions. A discursive review was undertaken examining trends, causes, implications, and interventions in burnout and well-being in healthcare staff working in mental health services. Data were drawn from national surveys, reports, and peer-reviewed journal articles. These show that staff in mental healthcare report poorer well-being than staff in other healthcare sectors. Poorer well-being and higher burnout are associated with poorer quality and safety of patient care, higher absenteeism, and higher turnover rates. Interventions are effective, but effect sizes are small. The review concludes that grounding interventions in the research literature, emphasizing the positive aspects of interventions to staff, building stronger links between healthcare organizations and universities, and designing interventions targeting burnout and improved patient care together may improve the effectiveness and uptake of interventions by staff.
VoIP Service over Multihop 802.11 Networks with Power Capture and Channel Noise

The quick market growth and ubiquitous acceptance of VoIP are primarily due to cheap service. VoIP services can be availed in mobile devices at a very low cost by employing IEEE 802.11 to provide last mile coverage. But call capacity is very low in these networks and call jitter occurs if voice quality requirements are not precisely met. We present a VoIP call capacity model for 802.11 networks which considers the most important real world factors like power capture and imperfect channel. Incorporating multiple channels can increase call capacity while multihop network can provide considerably large coverage. Our capacity model incorporates the effects of both multiple channels and multihop networks. We also consider the availability of multiple radio interfaces and conference call scenarios for ubiquitous applications of our model. To ensure voice quality, in addition to contention analysis, we also model the queue considering collision domain at each hop and formulate call capacity by estimating precise impairment budget over multihop.
Electrical transport in Mn‐doped GaAs pn‐diodes

We have studied the effect of magnetic ordering on the electrical transport in magnetic GaAs diodes. The fabricated pn‐junctions consist of Mn‐doped ferromagnetic layers on top of non‐magnetic semiconductor substrates. First the electrical and magnetic properties of the magnetic layers are investigated, which shows that the exchange interaction between the charge carriers and the localized magnetic moments of the Mn‐atoms dominates the charge transport at temperatures close to the Curie temperature. In the Gax Mn1–x As/GaAs‐p++n++‐junctions having heavily doped p‐ and n‐regions, the inter‐band tunnelling current shows large dependence on the magnetic ordering. The spin‐dependent tunnelling can be explained by a model, where the density of valence band states decreases due to the band splitting caused by the exchange interaction. From the measured decrease of the tunnelling current we estimated the value for the exchange parameter $ J^{\rm pd}_{\rm exch} $ = 2.9 eV. Various explanations for the absence of magnetoresistance in the magnetic diodes with lightly doped non‐magnetic regions are discussed. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Knowledge Creation Process and Sustainable Competitive Advantage: the Role of Technological Innovation Capabilities

This study examines the relationship between the knowledge creation process and technological innovation capabilities, and analyzes their effect on a firm’s sustainable competitive advantage using a knowledge-based view theoretical framework. We conduct structural equation modeling analyses using survey data from 315 Chinese industrial firms to test the direct and indirect effects of the knowledge creation process on sustainable competitive advantage. Technological innovation capabilities—operationalized to reflect the dimensions of process innovation capability and product innovation capability—are used as the mediating variable for explaining the relationship between the knowledge creation process and sustainable competitive advantage. The results indicate that the knowledge creation process does not have a significant direct effect on sustainable competitive advantage. Rather, the knowledge creation process can only influence the sustainable competitive advantage through the mediating effect of technological innovation capabilities completely. Consequently, the knowledge creation process favors the development of technological innovation capabilities for processes and products, because processes and products can lead to a sustainable competitive advantage.
Egg production , egg quality , and lipid peroxidation status in laying hens maintained at a low ambient temperature ( 6 ° C ) and fed a vitamin C and vitamin E-supplemented diet

This experiment was conducted to evaluate the effects of vitamin C (L-ascorbic acid) and vitamin E (α-tocopherol acetate) on egg production, egg quality, lipid peroxidation status (measured as MDA), and some serum metabolites in laying hens (Hy-Line) maintained at a low ambient temperature (6°C). One hundred and twenty laying hens (18-wk-old) were divided into four groups, 30 hens per group. The laying hens were fed either a basal diet or the basal diet supplemented with either 250 mg of L-ascorbic acid/kg of diet, 250 mg of α-tocopherol acetate/kg of diet or 250 mg of L-ascorbic acid plus 250 mg of α-tocopherol acetate/kg of diet. Although feed consumption of the hens was similar (P > 0.05) among treatments, supplemental vitamin C and E significantly increased final body weight, egg production, and improved feed efficiency (P < 0.05). Egg weights were also greater (P < 0.05) in hens supplemented with the combination of vitamin C and E than that of hens supplemented either vitamin or no vitamin (control). Haugh unit did not change upon each vitamin supplementation, but the combination of the vitamin supplement yielded a higher Haugh unit (P < 0.05). Each dietary supplement of vitamin C and vitamin E improved the egg quality (P < 0.05) resulting in a greater specific gravity, thicker egg shell, and heavier egg shell weight. Separately or as a combination, supplemental vitamin C and E decreased MDA, glucose, cholesterol, and triglyceride concentrations (P < 0.05). Results of the present study showed that supplementing vitamin C and vitamin E, particularly as a combination, improved the performance of cold-stressed laying hens, offering a potential protective management practice in preventing cold stress-related losses in performance of laying hens. Results of the present study also indicated that the effects of vitamin C and vitamin E are additive.
Comparison of Methods for Permanent Magnet Eddy-Current Loss Computations With and Without Reaction Field Considerations in Axial Flux PMSM

This paper presents an analytical solution of the eddy currents in the permanent magnets (PMs) in the axial flux PM synchronous machine using a coupled solution of Maxwell's equations and electric circuit network. This is based on calculating the axial field in an accurate way on the surface of the PM. This method is able to consider the effect of armature field and slots. The eddy currents are obtained by imposing this solution on the PM which is modeled by a simple electric network. This network is composed of simple resistances and inductances. The inductances are used to model the reaction field effect of the eddy currents flowing through the PM and also the skin effect. To show this effect, the machine is excited with different sources at different speeds. In addition, a variant of the model is made that neglects the inductances, in order to show in which conditions this low-frequency approximation is acceptable. It is concluded from this paper that inclusion of the reaction field is necessary when the machine is excited by a pulsewidth modulated (PWM) current, while for a sinusoidal excitation, the reaction field effect has minor contributions to the total eddy losses. In addition, the reaction field has major influence at higher speeds rather than lower speeds for PWM injection. In conclusions, for a preliminary design, the resistance model without the reaction field computation would be enough for the calculation of the PM losses. The circuit model is also capable of obtaining the solution with PM segmentation. In this paper, different PM segments were studied from the circuit model and the finite-element (FE) model point of view. Compared with the FE model, the circuit model has the advantage of flexibility in geometrical machine parameters, less CPU time, and accurate results for the PM losses up to 10%.
Clinical Presentation, Differential Diagnosis, and Vasodilator Testing of Pulmonary Hypertension

Clinicians should be cognizant of the symptoms and risk factors associated with pulmonary hypertension (PH). While known PH poses significant therapeutic challenges, occult PH carries the added potential for unanticipated complications when treating concurrent medical illnesses. PH may occur with underlying medical conditions and risk factors or may occur de novo as idiopathic pulmonary arterial hypertension (IPAH). Symptoms of PH are frequently attributed to more common conditions, and their nonspecific nature and insidious onset may lead to delay in presentation, evaluation, and diagnosis. Initial symptoms are dyspnea, fatigue, chest pain, and palpitations. Lower extremity edema, presyncope, and syncope are symptoms of more advanced disease. Thorough evaluation of symptoms and identification of patients with risk factors for PH are critical in making a timely diagnosis. History and physical examination can identify patients with suspected PH. Further testing is necessary for definitive diagnosis, classification, assessment of severity, and guiding therapeutic decisions.