Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Some Antioxidants on Rats Treated With Titanium Dioxide Nanoparticles

Titanium Dioxide Nanoparticles (TiO2NPs) is used in the production of food colorants, some nutritional supplements and many other products on large scale. Many studies stated that the TiO2NPs are more toxic than titanium dioxide (TiO2) and as possibly carcinogenic to humans. The aim of study was carried out to investigate the impacts of vitamin C and vitamin E on free radicals and antioxidant enzymes activities in male rats treated with TiO2NPs. The obtained results showed that, there were no significant (P≥0.05) differences found in red blood cells (RBC), hematocrit (Ht), hemoglobin (Hb) and platelets count (PLT) after treated with titanium dioxide nanoparticles (TiO2NPs) or natural antioxidants (vitamin E and C). The treatment with TiO2NPs alone caused significant (P≤0.05) increase in kidney and liver functions, while the oral intake of V.C and V.E or V.C+V.E reduced this increase. Also, the treatment with TiO2NPs increased the level of free radicals and decreased the activity of some antioxidant enzymes such as Superoxide dismutase (SOD), Glutathione-S-transferase (GST) and the content of Glutathione (GSH) in plasma. Meanwhile, V.C and V.E decreased the increased in free radicals and protected the activity of antioxidant enzymes in plasma of TiO2NPs- treated rats.
PANOA/MnO2/MWCNT nanocomposite: Synthesis, characterization, and electrochemical performance as efficient electrode materials for supercapacitors

Abstract The MnO2/multi-walled carbon nanotube (MWCNT)/poly (aniline-co-o-aminophenol) (PANOA) nanocomposite electrode were prepared by electrochemical polymerization on graphite electrode. Cyclic voltammetry and galvanostatic charge/discharge used the electrochemical properties of the composite. The doping of MnO2/MWCNT enhances the electrochemical activity and reversibility of the copolymer. Scanning electron micrographs (SEM), UV–vis spectra, and X-ray diffraction diagram clearly revealed the formation of nanocomposites on the surface of the working electrode and demonstrated that the doping process is effective. The test results in acidic solutions show that the composites have similar and enhanced cyclic voltammetry performance compared with pure PANOA based electrode material. The PANOA/MnO2/MWCNT nanocomposite synthesized possessed excellent capacitive behavior with a high specific capacitance. The specific capacitance of the PANOA/MnO2/MWCNT nanocomposite film is 560 F/g at scan rate of 25 mV s−1. These results demonstrate exciting potentials of the composite for high performance supercapacitors or other power source system.
The Synthesis and in Vitro Toxicological Evaluation of the Mitoxantrone Naphthoquinoxaline Metabolite: A Comparative Study with the Parent Drug

in international journals: A. Reis-Mendes, E. Sousa, F. Remião, F. Carvalho, M.L. Bastos, and V.M. Costa, “At pharmacology relevant concentrations, mitoxantrone causes timeand concentrationdependent toxicity in H9c2 differentiated cells with autophagy involvement” Toxicol Lett 229, Supplement: S246.
Changes in chlorophyll fluorescence parameters during desiccation and osmotic stress of Hassallia antarctica culture

Hassallia antarctica is a terrestrial cyanobacterium colonizing various habitats in Antarctica such as soil surface, microbiological mats and seepages. H. antarctica represents one of the cyanobacterial species forming biodiversity of terrestrial autotrophs of James Ross Island, Antarctica. It is a filamentous cyanobacterium composing blackish fasciculated clusters thanks to false branching. In our study, sensitivity of the species to dehydration and salt stress was studied. We used H. antarctica culture (CCALA 956) grown on Z liquid medium. Clusters of H. antarctica were placed on wet filter paper and dried naturally at 5°C. During gradual dehydration, relative water content (RWC) was evaluated gravimetrically simultaneously with chlorophyll fluorescence measurements. Slow Kautsky kinetics and the chlorophyll fluorescence parameters (FV/FM, ФPSII) were used to assess dehydration-related decrease in primary photosynthetic processes. It was found that H. antarctica, contrastingly to other terrestrial cyanobacteria from polar habitats, was not able to maintain photosynthetic processes at RWCs as low as 20%. Even during initial phase of dehydration (RWC of 95%) rapid decline in FV/FM occured. Resistance of H. antarctica to osmotic stress was studied by time courses of the chlorophyll fluorescence parameter in response to 3.0, 0.3, and 0.03 M NaCl solution. Both shape of slow Kautsky kinetics and numeric values of chlorophyll fluorescence parameters were affected by osmotic stress. While full inhibitory effect was apparent in 3.0 M NaCl treatment immediately, the salt stress-induced decline in chlorophyll fluorescence parameters was observed at 0.03 M NaCl even after 8 hours of exposition. It was, therefore, concluded that H. antarctica exhibited high resistance to osmotic stress which may help the species to cope with repetitive dehydration events that happen in the field during austral summer season in Antarctica, James Ross Island in particular.
Computational analysis to study the effect of infusion of Tetracyanoquinodimethane in zinc based metal-organic framework

The present study reports the computational analysis of band structures and density of state (DOS) profiles of a Tetracyanoquinodimethane (TCNQ) infused IRMOF-1 (Iso Reticular Metal-Organic Framework-1). IRMOF-1 is a zinc-based MOF and has been reported useful in literature for a variety of applications, including gas storage and sensing owing to its highly porous structure. We have adopted a SIESTA based computational investigation approach to investigate the tuning of the band structure and DOS of IRMOF-1 via the infusion of a redox active species, i.e., TCNQ. The results have highlighted that the doping of TCNQ in IRMOF-1 is useful for the realization of a novel material with an estimated band gap of 4.35 eV. The necessary computational steps involved various optimization steps, such as the optimization of mesh-cutoff, lattice constant, lattice volume, and conjugate gradient. These computation studies have thus established that an approach of doping IRMOF-1 with TCNQ can result in the development of a suitably functional porous material that can be further exploited as an ultrawide‐bandgap semiconductor material or for the electrochemical sensing of different analytes, such as gases.
Assessment of drug interactions in elderly patients of a family health care unit in Aracaju (Brazil): A pilot study

This pilot study aimed to assess drug-drug and drug-food interactions in elderly patients of a Family Health Care Unit in Aracaju, Brazil. A descriptive pilot study was performed through an interview questionnaire with 35 elderly patients (28 women) of the Family Health Care Unit. The range of consumed medications was 1 to 7, and the rate was 3.1 medications/person. This pilot study identified that 34 elderly used multiple medication and its related problems such as risk of polypharmacy (5) and drug interaction (34). The class of drugs most commonly used was related to cardiovascular system, and alimentary tract and metabolism. Prescriptions with 2 to 3, 4 to 5 and 6 to 7 medications showed potential drug-drug interaction (39, 88.8 and 100%, respectively). Some drugs could not be administrated at meal time. These findings highlight the need for additional studies to further evaluate clinical outcomes associated with polypharmacy and potential drug-drug and drug-food interactions.
A wearable augmented reality system to improve the quality of life of sedentary people

The sedentary lifestyle is a common problem in most countries, such as Mexico. For that reason, it's necessary to promote a lifestyle change that includes physical activities and a healthy nutrition. The objective of this paper is to provide a technological solution to motivate people to walk, receive health benefits, and additionally, receive points, which can be exchanged for prizes. With this we pretend to motivate people to walk and improve their health. Thus, if a person doesn't walk to improve their health, we will encourage it with a prize.
Phytochemical Analysis and Anti Oxidant Activity of White, Red and Black Abrus precatorius Linn (Gunja): Comparative Studies.

Objective To find the chemical and biological (Antioxidant action) variability of three verities of Gunja (Abrus precatorius Linn.) leaf based on its fruit color i.e., White, Red and Black. Methods The aqueous and alcoholic extracts of all varieties were screened for phytoconstituents using preliminary chemical test, chromatographic fingerprinting using LC-MS. The possible antioxidant activities were screened by free radical scavenging activity (DPPH), FRAP inhibition method. Results The results showed that the three varieties vary a little bit in their phytoconstituents. All the extract possessed antioxidant in a dose-dependent manner. Conclusions This study suggests that aqueous extract of leaves of red variety of Abrus precatorius L extracts exhibit great potential for antioxidant activity and may be useful for their nutritional and medicinal functions. Keywords: Abrus precatorius L, Gunja , DPPH, oxidative stress, Antioxidan
Development and evaluation of polyherbal formulation for memory enhancement: study on its antioxidant properties and synergistic effects

Centella asiatica, Piper sarmentosum and Morinda citrifolia is well-known for their memory enhancement contribution from traditional practices as well as recent researches. However, all three herbs are utilized individually and never mixed together. The nutrient data on the synergistic effect on all three herbs remain scarce. The aims of this research project were to apply Simplex-centroid mixture design in describing the study for the effect of polyherbal formulation on antioxidants properties and its synergistic effects. Based on results obtained, there was a significant difference in antioxidant properties of the polyherbal formulation. The results show the polyherbal formulation 3 and 13 (M. citrifolia only) has the highest antioxidant capacity when being tested with total phenolic content (TPC) (210.10 and 209.12 µg GAE/mL respectively) and 2,2-diphenyl-1- picrylhydrazyl (DPPH) (42.94 and 37.77%) assays. Contradict to this result, the highest in total flavonoid content (TFC) and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) for describing antioxidant properties are formulations 1 and 11 (C. asiatica only). The TPC for formulation 1 and 11 are 479.8 µg RE/mL and 470 µg RE/mL respectively while ABTS radical inhibition for formulation 1 and 11 are 64.53% and 60% respectively. For ferric reducing ability of plasma (FRAP) assay, formulation 7 (2.11 µg FSE/mL) is the highest which have 1:1:1 ratio of each herb. In addition, TPC, TFC, and DPPH assays showed high antioxidant activities when only single herbs were added into the formulation. Meanwhile, ABTS and FRAP are prone to binary polyherbal formulation. Hence, this study showed an antagonism effect instead of synergistic effect since single formulation exhibited the highest for TPC, TFC and DPPH. All tests gave the lowest antioxidant properties when the mix was ternary polyherbal formulation.
NEUTRALIZATION OF DROUGHT STRESS AND IMPROVING GROWTH, WATER STATUS, YIELD AND QUALITY OF JERUSALEM ARTICHOKE (Helianthus tuberosus L.) USING COMPOST, HUMIC ACID AND SUPERABSORBENT POLYMER

Drought is the most serious problem in agriculture wide world, especially in arid and semiarid regions. Application of soil conditioners could increase water retention and decrease leaching of water and fertilizers from the soil. This study was conducted on Jerusalem artichoke (JA) cv. Fuseau in Baramoon Research Station, Dakahlia Governorate, Egypt during the growing seasons of 2013-2014. Two irrigation regimes (10 and 20 days’ intervals starting after 1 st irrigation) in combination with compost, humic acid and superabsorbent polymer (SAP) were evaluated to increase irrigation efficiency under drought stress. The vegetative growth parameters, water status, marketable and total tuber yield, dry matter production, inulin yield, nitrogen and proline contents and water use efficiency of JA plants were investigated. Under drought stress (irrigation at 20 days), all the studied parameters except for leaf water deficit, proline content and water use efficiency (WUE) tend to decrease in both seasons. Dual application of SAP with compost or humic acid led to significant increases in all studied criteria, compared to check or other treatments. Under normal irrigation period (10 days’ intervals), all tested criteria were found to be significant, especially at application of compost as soil amendments, in both seasons. Additionally, incorporating SAP dually with compost or humic acid under deficient irrigation water improved WUE and decreased water requirement by 50%. Also, the tuber yield and physiological quality characters were found to be equivalent to the control treatment under normal irrigation conditions. This in turn encourages such amendments to reduce water consumption.
Lack of benefit in treating high homocysteine levels with vitamins

Homocysteine-lowering vitamin therapy has been widely pre- scribed in the belief that it will reduce cardiovascular events. While epidemiological studies have indi- cated a strong association between high plasma homocysteine levels and risk of cardiovascular disease, several recent prospective trials of homocysteine lowering with folic acid, vitamin B6, and vitamin B12 have failed to show any benefit in patients with established cardio- vascular disease. Three recent pro- spective randomized trials (VISP, NORVIT, and HOPE 2) suggest that measurement of homocysteine is not required for the management of most patients and that treating mod- erate hyperhomocysteinemia with vitamins does not reduce cardiovas- cular events. I n 1969, McCully suggested that elevated levels of plasma homo- cysteine (Hcy) are associated with atherosclerosis. 1 He noted high prevalence of hyperhomocys- teinemia in patients with coronary artery disease (CAD) when compared with the general population. A num- ber of other observations linking homocysteine with CAD followed. 2,3
Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells

Glypicans are a family of glycosylphosphatidylinositol-anchored cell sur- face heparan sulfate proteoglycans implicated in the control of cellular growth and differentiation. Here we show that glypican-1 is strongly ex- pressed in human breast cancers, whereas expression of glypican-1 is low in normal breast tissues. In contrast, the expression of glypican-3 and -4 is only slightly increased in breast cancers by comparison with normal breast tissues, and glypican-2 and -5 are below the level of detection by Northern blotting in both normal and cancer samples. Treatment of MDA-MB-231 and MDA-MB-468 breast cancer cells with phosphoinositide-specific phospholipase-C abrogated the mitogenic response to two heparin-binding growth factors, heparin-binding epidermal growth factor-like growth factor and fibroblast growth factor 2. Stable transfection of these cells with a glypican-1 antisense construct markedly decreased glypican-1 protein levels and the mitogenic response to the same heparin-binding growth factors, as well as that to heregulin a , heregulin b , and hepatocyte growth factor. Syndecan-1 was also expressed at high levels in both breast cancer tissues and breast cancer cells when compared with normal breast tissues. There was a good correlation between glypican-1 and syndecan-1 expression in the tumors. However, clones expressing the glypican-1 antisense construct did not exhibit decreased syndecan-1 levels, indicating that loss of responsiveness to heparin-binding growth factors in these clones was not due to altered syndecan-1 expression. Furthermore, 8 of 10 tumors with stage 2 or 3 disease exhibited high levels of glypican-1 by Northern blot analysis. In contrast, low levels of glypican-1 mRNA were evident in 1 of 10 tumors with stage 2 or 3 disease and in 9 of 10 tumors with stage 1 disease. Taken together, these data suggest that glypi-can-1 may play a pivotal role in the ability of breast cancer cells to exhibit a mitogenic response to multiple heparin-binding growth factors and may contribute to disease progression in this malignancy. in the present study we investigated the expression and action of glypicans and syndecan-1 in breast cancer. We now report that glypican-1 and syndecan-1 are overexpressed in human breast cancer and that stable expression of a glypican-1 antisense mRNA in breast cancer cells results in reduced glypican-1 protein expression, leading to an attenuated mitogenic response to HRG- a , b , and HGF.
Chromatographic Applications in Medicine

Son yillarda kromatografi, bir ilacin ve metabolitlerinin tanimlanmasi ve nicellestirilmesi icin en onemli analitik yontemlerden biri olarak medikal alanda tercih edilmektedir. Ilaclarin ozellikleri ve etkilesim tiplerine gore ayirmak icin cesitli kromatografik teknikler gelistirilmistir. Bu teknikler, Yuksek performansli afinite kromatografisi (HPAC), Hucre membran kromatografisi (CMC), Karma modlu kromatografi (MMC), Sivi kromatografisi (LC) klinik oncesi ve klinik calismalarda ilaclarin biyoanalizi icin farmasotik amacli kullanilmaktadir. Kromatografinin hizli ve hassas analitik yontemler gelistirilmesindeki basarisi, ilaclarin AR-GE'deki farmakokinetik ozelliklerinin arastirilmasinda da ustun ozgunluk ve duyarlilik saglar. Kisisellestirilmis tipta ilaclarin dozaji ve etkisi kisiden kisiye nasil degisiklik gosterdigi onemlidir. Kromotografi, ilac-protein baglanmasinin analizi ve klinik veya farmasotik numunelerin incelenmesinde umut verici bir teknik haline gelmistir.
Multiperiod heating storage control for distributed electric heating considering wind curtailment accommodation

Electric heating is perceived as an effective way to tackle heavy wind curtailment and severe smog in northern China, wherein distributed electric heating (DEH) accounts for a significant proportion. However, more research is required with regard to its thermal characteristic. This paper presents the multiperiod heating storage control for a DEH load to reduce wind curtailment. To cope with intermittent wind power, a novel multi‐objective and layered optimization method is proposed by decomposing the integrated electricity and heating optimization problem into the electricity optimization subproblem and the heating optimization subproblem. Additionally, the influence of solar radiation on the thermal characteristic of the DEH load is considered in the building thermal process model when creating the day‐ahead schedule of the DEH load control, and this is also regarded as the basis for grouping DEH users. Last, the simulation and economic feasibility analysis based on the data measured by the DEH system of Jilin Province, China, are carried out. The results show that this proposal can reduce the electricity cost for DEH users by 25%, and the critical feasible price for curtailed wind power is varying between 86.1 and 115.3 yuan/MWh according to different subsidy methods.
Comprehensive Analysis on Dynamic Heat Generation of LiNi1/3Co1/3Mn1/3O2 Coin Cell under Overcharge

To meet the requirement of fast charging and high energy density of lithium ion battery, it is critical to further study the impact of current and voltage on the heat generation. In this work, dynamic heat generation of LiNi1/3Co1/3Mn1/3O2 coin cell under different current rates and overcharge voltages is investigated in detail using an in-situ micro-calorimetry. Polarization is the main factor causing rapid increase of heat generation at high current rate. The internal resistance and entropy coefficient show a great consistency of tendency and magnitude between irreversible and total heat. The excessive delithiation accelerates the polarization of electrode and the oxidation of electrolyte, leading to larger amount of heat generation. Besides, the heat release rate of charging process gets a steep increase as the cutoff voltage exceeds 4.5 V. Under the voltage range of 2.8–4.9 V, the heat generation from abusive range contributes more than 58% to the whole process. With the degradation of electrochemical performance, crystal structure and thermal stability also become worse after 50 cycles under higher cutoff voltage. These results provide basic data for the design of current rate and voltage range and the improvement of thermal management system.
Desenvolvimento de métodos analíticos para a análise de própolis utilizando técnicas espectrométricas e análise multivariada

Neste trabalho, metodos quimiometricos de analise exploratoria como a Analise por Componentes Principais e Analise Discriminante com o Metodo dos Minimos Quadrados Parciais foram utilizados para classificar extratos comerciais de propolis das regioes sul e sudeste do Brasil, com o objetivo de avaliar a procedencia dos mesmos. Um modelo de calibracao multivariada utilizando o Metodo dos Minimos Quadrados Parciais foi construido e validado para determinacao do teor de extrato seco em extratos comerciais de propolis. A metodologia quimiometrica proposta para a determinacao do teor de extrato seco em extratos comerciais de propolis mostrou-se uma alternativa adequada em relacao a metodologia tradicional gravimetrica, por ser mais rapida, menos laboriosa e por envolver pequenas quantidades de solventes. Uma otimizacao do metodo Folin-Ciocalteu para determinacao do teor de fenois totais em extratos de propolis foi realizada, na qual avaliou-se as quantidades dos reagentes Folin-Ciocalteu e de tampao carbonato de sodio, tempo de reacao, espalhamentos da radiacao, formacao de solidos em suspensao e deslocamento hipsocromico do comprimento de onda de maxima absorcao. A otimizacao da metodologia espectrofotometrica Folin-Ciocalteu agregou vantagens a metodologia proposta, como reducao de custos e de tempo de analise, alem da obtencao de um metodo exato. A determinacao do teor de fenois totais dos extratos de propolis estudados foi realizada atraves do metodo Folin-Ciocalteu, obtendo-se valores adequados ao estipulado pela legislacao brasileira. Analises cromatograficas dos extratos das regioes sul e sudeste do Brasil, de propolis verde e comum, foram realizadas. Pode-se verificar uma semelhanca na composicao quimica dos extratos de propolis comum e verde da regiao sudeste, indicando que estes, independentemente da sua rotulacao, apresentaram a mesma composicao quimica. Nestes extratos, os compostos fenolicos majoritarios foram o artepillin C e pinocembrina. Para os extratos da regiao sul observou-se grande variacao na composicao quimica.