Miracle-dz/UniFAR-FTUs huggingface dataset:
A Flexible and Efficient System Development Approach for Enterprise System and Smartphone Application

-The business environment has accelerated sharply year by year. However, the information system does not catch up the rapid change. A certain gap arises between the business strategy and IT. On the other hand, the use of smartphones in the enterprise system has been increasing. The possibility of the use of BYOD (Bring Your Own Device) is also increasing. However, smartphone is necessary to cope with different platforms such as iOS and Android. There is a problem in development effort is increasing. Approaching this problem, this paper aims to resolve a combination of two concepts of SOA and BPM,. In the proposal approach, we apply the agile development process to which the change in the requirement is brilliantly accepted. The grasped requirement is listed and the order of priority is applied at the time of beginning of development. Next, it develops from the function with high priority one by one. When the change and the addition of the requirement occur, priority is reviewed. As mentioned above, our approach accepts the change and the addition of the requirement, and develops them according to priority. As a result, system implementation to be worthy for the customer in the delivery date becomes possible. In this paper, we propose the design-approach that combines BPM, SOA, and agile development for the enterprise system and smartphone application development to which the specification is not fixed. Additionally, we prove the effectiveness of our proposal by the application experience. Key-Words: Agile Development Process, BPM, Component, Feature List, Information System Development, SOA, Enterprise system, Smartphone Application
An attempt to predict quality changes in a ten-component granular system

Pokusaj predviđanja promjena kvalitete u zrnatom sustavu od deset sastojaka Izvorni znanstveni clanak U radu se opisuje pokusaj predviđanja promjena kvalitete u nehomogenom zrnatom sustavu od deset sastojaka tijekom mijesanja na liniji za mijesanje uređaja sastavljenog od mjesalice hrane, ulaznog lijevka i lopatastog transportera. Postupak mijesanja se provodio uz dodatnu vanjsku recirkulaciju sastojaka preko lopatastog transportera. Postupak se temeljio na znanju o promjenama kvalitete tijekom vremena kod mjesavine koja se sastojala od devet sastojaka, jedanaest sastojaka i dvanaest sastojaka. Postupak je proveden u dva stadija: u prvom se kvaliteta zrnatih mjesavina odredila primjenom preostale sume kvadrata (residual sum of squares), u drugom su varijable modelirane primjenom nelinearne regresije. Zavisna varijabla je bila preostala suma kvadrata, dok su nezavisne varijable bile: broj sastojaka i vrijeme mijesanja. Dvodimenzionalna zavisnost je opisana kvadratnom funkcijom. Kljucne rijeci: mjesavina s vise sastojaka, modeliranje, nasipna težina zrnate materije, vertikalna mjesalica
Modelling the Thyroid Geometry

Given a single bidimensional ultrasonogram or scintigraphic image, we consider the feasibility for a tridimensional reconstruction of a human gland or organ. In particular, the reconstruction of one lobe of the thyroid gland is considered. The output sought, besides the visualization of the organ in space, is the approximation of the functional and morphological volume of the organ; this value is also taken as the approximation of the vascularization volume.
Treatment of Patients with Aortic Dissection Presenting with Peripheral Vascular Complications

The Incidence of peripheral vascular complications in 272 patients with aortic dissection during a 25-year span was determined, as was outcome after a uniform, aggressive surgical approach directed at repair of the thoracic aorta. One hundred twenty-eight patients (47%) presented with acute type A dissection, 70 (26%) with chronic type A, 40 (15%) with acute type B, and 34 (12%) with chronic type B dissections. Eighty-five patients (31%) sustained one or more peripheral vascular complications: Seven (3%) had a stroke, nine (3%) had paraplegia, 66 (24%) sustained loss of a peripheral pulse, 22 (8%) had Impaired renal perfusion, and 14 patients (5%) had compromised visceral perfusion. Following repair of the thoracic aorta, local peripheral vascular procedures were unnecessary in 92% of patients who presented with absence of a peripheral pulse. The operative mortality rate for all patients was 25% ± 3% (68 of 272 patients). For the subsets of individuals with paraplegia, loss of renal perfusion, and compromised visceral perfusion, the operative mortality rates (± 70% confidence limits) were high: 44% ± 17% (4 of 9 patients), 50% ± 11% (11 of 22 patients), and 43% ± 14% (6 of 14 patients), respectively. The mortality rates were lower for patients presenting with stroke (14% ± 14% [1 of 7 patients]) or loss of peripheral pulse (27% ± 6% [18 of 66 patients]). Mul-tivariate analysis revealed that impaired renal perfusion was the only peripheral vascular complication that was a significant independent predictor of Increased operative mortality risk (p = 0.024); earlier surgical referral (replacement of the appropriate section of the thoracic aorta) or more expeditions diagnosis followed by surgical renal artery revascularization after a thoracic procedure may represent the only way to Improve outcome in this high-risk patient subset. Early, aggressive thoracic aortic repair (followed by aortic fenestration and/or abdominal exploration with or without direct visceral or renal vascular reconstruction when necessary) can save some patients with compromised visceral perfusion; however, once visceral Infarction develops, the prognosis Is also poor. Increased awareness of these devastating complications of aortic dissection and the availability of better diagnostic tools today may Improve the survival rate for these patients In the future. The initial surgical procedure should Include repair of the thoracic aorta in most patients.
Object-oriented implementation of a DICOM network client in Smalltalk

Most of the digital medical devices used in modern clinics and practice provide data corresponding to the DICOM Standard. Cyclops, a knowledge-based image analysis system developed at the University of Kaiserslautern, was suitable to analyze such images, but we needed a DICOM interface to connect to DICOM databases easily and transfer data to the system. All non-commercial software available were not up to our demands, so we implemented a DICOM network client by our own, which can connect to the ctn image server, based on an SQL database. We attached great value to a neat, object-oriented implementation, because it is easy to expand and we are flexible to future versions of the DICOR/I standard.
Automatic speaker verification: A review

The relation of speaker verification to other pattern-recognition problems in speech is discussed, especially the distinction between speaker verification and speaker identification. The prospects for automatic speaker verification, its settings and applications are outlined. The techniques, evaluations, and implementations of various proposed speaker recognition systems are reviewed with special emphasis on issues peculiar to speaker verification. Two large-scale operating systems using different analysis techniques and applied to different settings are described.
Design and Architecture of 'Anusaaraka'- An Approach to Machine Translation

Most research in Machine translation is about having the computers completely bear the load of translating one human language into another. This paper looks at the machine translation problem afresh and observes that there is a need to share the load between man and machine, distinguish ‘reliable’ knowledge from the ‘heuristics’, provide a spectrum of outputs to serve different strata of people, and finally make use of existing resources instead of reinventing the wheel. This paper describes the architecture and design of ‘Anusaaraka’ based on the fundamental premise of sharing the load, resulting in “good enough” results according to the needs of the reader. The architecture differs from the conventional in three major ways: � Reversal in the order of operations as compared to conventional machine translation systems
Continuity of Care to Prevent Readmissions for Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

ABSTRACT Readmissions of patients with chronic obstructive pulmonary disease (COPD) to hospitals cast a heavy burden to health care systems. This meta-analysis was aimed to assess the efficacy of continuity of care as interventions, which reduced readmission and mortality rates of such patients. PubMed, Cochrane Library and Embase were searched for articles published before July 2015. A total of 31 reports with randomized controlled trials (RCTs) were finally included in this meta-analysis. The results showed that health education reduced all-cause readmission at 3 months. In addition, health education, comprehensive nursing intervention (CNI) and telemonitoring reduced all-cause readmissions over 6–12 months, and the effect of CNI was best because CNI also reduced COPD-specific readmissions. Home visits also reduced COPD-specific readmissions (the quality more than moderate), but it did not reduce the risk for all-cause readmissions (risk ratios (RRs), 0.92 [95% CI, 0.82–1.04]; moderate quality). There was no statistically significant difference in reducing mortality and quality of life (QOL) among various continued cares. In conclusion, CNI, telemonitoring, health education and home visits should receive more consideration than other interventions by caregivers seeking to implement continued care interventions for patients with COPD.
Quantitative analysis of biodegradable polymers (PLLA & PCL) thermal bonding

A quantitative analysis of the bond strength and microstructure integrity achieved when bonding the biodegradable polymers poly(L-lactide) (PLLA) and poly(e-caprolactone) (PCL) is realized using the response surface methodology (RSM). For the present packaging application the bonding parameters (temperature, pressure, duration) are adapted to optimize the bond strength; The estimated values for bond strength and channel integrity that are predicted by the surface plots are 2.32±0.26MPa and 33.7±12.9% for PLLA, and 0.81±0.11MPa and 50.9±5.7% for PCL. These values are in good agreement with the experimentally determined bond strength of 2.00±1.10MPa (PLLA) & 0.67±0.22MPa (PCL) and deformation of 31.4±7.0% (PLLA) & 52.9±4.1% (PCL). Microchannels with aspect ratio of 1∶12.5 are also fabricated.
Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners.

OBJECTIVES Recent studies have shown an excess risk of asthma for cleaners, but it is not clear which cleaning-related exposures induce or aggravate asthma. METHODS Risk factors for asthma were studied among indoor cleaners participating in the Spanish part of the European Community Respiratory Health Survey in 1992. In 1998, 78 of the 91 subjects reporting cleaning-related jobs in 1992 were identified. Of these, 67 indoor cleaners were interviewed by telephone about their cleaning activities and their use of cleaning products in 1992. These data were related to asthma prevalence in 1992, and the cleaners were compared with a reference group of office workers. RESULTS Asthma prevalence was 1.7 times higher [95% confidence interval (95% CI) 1.1-2.6] among the cleaners than among the referents, being highest among private home cleaners (3.3, 95% CI 1.9-5.8). The prevalence of housedust mite sensitization amounted to 28% for the home cleaners and was significantly (P<0.01) higher than for other indoor cleaners (3%), but similar to the corresponding prevalence of office workers (22%). More than half of the cleaners reported work-related respiratory symptoms. The asthma risk of the home cleaners was mainly associated with kitchen cleaning and furniture polishing, with the use of oven sprays and polishes. CONCLUSIONS The asthma risk of Spanish cleaners is primarily related to the cleaning of private homes. This relationship may be explained by the use of sprays and other products in kitchen cleaning and furniture polishing.
A STANDARDIZED GENETIC DIFFERENTIATION MEASURE

Abstract Interpretation of genetic differentiation values is often problematic because of their dependence on the level of genetic variation. For example, the maximum level of GST is less than the average within population homozygosity so that for highly variable loci, even when no alleles are shared between subpopulations, GST may be low. To remedy this difficulty, a standardized measure of genetic differentiation is introduced here, one which has the same range, 0–1, for all levels of genetic variation. With this measure, the magnitude is the proportion of the maximum differentiation possible for the level of subpopulation homozygosity observed. This is particularly important for situations in which the mutation rate is of the same magnitude or higher than the rate of gene flow. The standardized measure allows comparison between loci with different levels of genetic variation, such as allozymes and microsatellite loci, or mtDNA and Y-chromosome genes, and for genetic differentiation for organisms with different effective population sizes.
The effect of N‐ethylmaleimide on transmitter release from the skeletal neuromuscular junction of Bufo marinus

N‐ethylmaleimide (NEM) has been used extensively in biochemical assays as an inhibitor of the NEM sensitive fusion protein (NSF). However, examination of the effect of NEM on transmitter release in more physiologically relevant preparations has proved inconclusive. In the present study, we have examined the effect of low concentrations of NEM on synaptic transmission in intact nerve‐muscle preparations from toads (Bufo marinus). Under conditions of low transmitter release probability (0.3 mM calcium, 1 mM magnesium), treatment with NEM (10 μM) caused a significant increase in the amplitude of stimulus‐evoked endplate potentials (EPPs) and a significant increase in the frequency of spontaneously occurring miniature EPPS (MEPPS) without affecting the amplitude of MEPPs. When the calcium concentration in the bath was raised to 4 mM, 10 μM NEM had no effect on EPP amplitude. Under these conditions, NEM treatment reduced paired pulse facilitation and increased depression during stimulus trains. Treatment with NEM also resulted in a significant decrease in the synaptic delay. The effects of NEM on transmitter release in the present study were not due to inactivation of G‐proteins. The results of the present study show a calcium‐dependent facilitation of stimulus‐evoked transmitter release by NEM. These results are discussed in terms of the possible sites of NEM action leading to the observed changes in transmitter release. Synapse 53:151–158, 2004. © 2004 Wiley‐Liss, Inc.
Identification of three aspartic acid residues essential for catalysis by the RusA holliday junction resolvase.

RusA is a Holliday junction resolvase encoded by the cryptic prophage DLP12 of Escherichia coli K-12 that can be activated to promote homologous recombination and DNA repair in resolution-deficient mutants lacking the RuvABC proteins. Database searches with the 120 amino acid residue RusA sequence identified 11 homologues from diverse species, including one from the extreme thermophile Aquifex aeolicus, which suggests that RusA may be of ancient bacterial ancestry. A multiple alignment of these sequences revealed seven conserved or invariant acidic residues in the C-terminal half of the E. coli protein. By making site-directed mutations at these positions and analysing the ability of the mutant proteins to promote DNA repair in vivo and to resolve junctions in vitro, we identified three aspartic acid residues (D70, D72 and D91) that are essential for catalysis and that provide the first insight into the active-site mechanism of junction resolution by RusA. Substitution of any one of these three residues with asparagine reduces resolution activity >80-fold. The mutant proteins retain the ability to bind junction DNA regardless of the DNA sequence or of the mobility of the crossover. They interfere with the function of the RuvABC proteins in vivo, when expressed from a multicopy plasmid, an effect that is reproducible in vitro and that reflects the fact that the RusA proteins have a higher affinity for junction DNA in the presence of Mg2+ than do the RuvA and RuvC proteins. The D70N protein has a greater affinity for junctions in Mg2+ than does the wild-type, which indicates that the negatively charged carboxyl group of the aspartate residue plays a critical role at the active site of RusA. Electrostatic repulsions between D70, D72 and D91 may help to form a classical Mg2+-binding pocket.
The Effect of Seasonal Weather Variation on the Dynamics of the Plague Disease

Plague is a historic disease which is also known to be the most devastating disease that ever occurred in human history, caused by gram-negative bacteria known as Yersinia pestis. The disease is mostly affected by variations of weather conditions as it disturbs the normal behavior of main plague disease transmission agents, namely, human beings, rodents, fleas, and pathogens, in the environment. This in turn changes the way they interact with each other and ultimately leads to a periodic transmission of plague disease. In this paper, we formulate a periodic epidemic model system by incorporating seasonal transmission rate in order to study the effect of seasonal weather variation on the dynamics of plague disease. We compute the basic reproduction number of a proposed model. We then use numerical simulation to illustrate the effect of different weather dependent parameters on the basic reproduction number. We are able to deduce that infection rate, progression rates from primary forms of plague disease to more severe forms of plague disease, and the infectious flea abundance affect, to a large extent, the number of bubonic, septicemic, and pneumonic plague infective agents. We recommend that it is more reasonable to consider these factors that have been shown to have a significant effect on for effective control strategies.
Glucose Turnover in Type I Diabetic Subjects During Exercise: Effect of selective and nonselective β-blockade and insulin withdrawal

OBJECTIVE To assess the effect of selective β1-blockade (atenolol and betaxolol) and nonselective β-blockade (propranolol) on glucose turnover in subjects with insulin-dependent (type I) diabetes mellitus during moderate exercise. RESEARCH DESIGN AND METHODS Five subjects with type I diabetes were infused with insulin and then exercised for 1 h, after pretreatment with each of the three drugs or saline and, on a separate day, after withdrawal of insulin. Glucose turnover was measured using tritiated glucose. RESULTS Plasma glucose, initially 9.2 ± 0.5 mmol/L (mean ± SE) when insulin infused and 14.0 ± 0.8 when insulin was withdrawn, fell on exercise by 3.4 ± 1.1 mmol/L (P < 0.05) saline, 4.0 ± 0.8 mmol/L (P < 0.01) with betaxolol, 3.8 ± 0.7 mmol/L (P < 0.01) with atenolol, 5.0 ± 0.6 mmol/L (P < 0.005) with propranolol, and 1.7 ± 1.0 mmol/L (NS) when insulin was withdrawn. Propranolol, but not the other β-blockers, caused a significantly greater fall in glucose on exercise than during the control study. Glucose appearance rate (Ra) was similar basally and rose to an almost identical level in all five groups during exercise. Glucose disappearance rate (Rd) rose similarly during exercise, except after propranolol when the rise was significantly greater with saline (P < 0.01). Failure of glucose to change significantly during exercise when insulin had been withdrawn was associated with the smallest rise in Rd and the highest nonesterified fatty acid concentrations. Propranolol and betaxolol, but not atenolol, reduced nonesterified fatty acids. CONCLUSIONS We conclude that the greater fall in glucose on exercise after β-blocking drugs is probably largely a direct effect of β2-blockade on muscle, increasing the exercise-induced rise in Rd glucose. This offers support to the use of β1-specific drugs, where β-blockade is necessary in type I diabetes.
Telomerase Reverse Transcriptase Has an Extratelomeric Function in Somatic Cell Reprogramming*

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells. Reactivation of the endogenous telomerase reverse transcriptase (TERT) catalytic subunit and telomere elongation occur during the reprogramming of somatic cells to induced pluripotent stem (iPS) cells. However, the role of TERT in the reprogramming process is unclear. To clarify its function, the reprogramming process was examined in TERT-KO somatic cells. To exclude the effect of telomere elongation, tail-tip fibroblasts (TTFs) from first generation TERT-KO mice were used. Although iPS cells were successfully generated from TERT-KO TTFs, the efficiency of reprogramming these cells was markedly lower than that of WT TTFs. The gene expression profiles of iPS cells induced from TERT-KO TTFs were similar to those of WT iPS cells and ES cells, and TERT-KO iPS cells formed teratomas that differentiated into all three germ layers. These data indicate that TERT plays an extratelomeric role in the reprogramming process, but its function is dispensable. However, TERT-KO iPS cells showed transient defects in growth and teratoma formation during continuous growth. In addition, TERT-KO iPS cells developed chromosome fusions that accumulated with increasing passage numbers, consistent with the fact that TERT is essential for the maintenance of genome structure and stability in iPS cells. In a rescue experiment, an enzymatically inactive mutant of TERT (D702A) had a positive effect on somatic cell reprogramming of TERT-KO TTFs, which confirmed the extratelomeric role of TERT in this process.
Globalization Pressures and the State: The Worldwide Spread of Central Bank Independence1

The authors examine the impact of globalization on state structures in the specific instance of the central bank. Following the world‐system, world‐society, and neoinstitutional perspectives in sociology, they assume that states are in cultural, political, and economic competition with each other, thereby seeking to maintain their position and status, frequently by adopting organizational forms or practices that make them isomorphic with their environment. The authors predict that countries boost the independence of their central bank from the political power as their exposure to foreign trade, investment, and multilateral lending increases. They also model the cross‐national dynamic process of diffusion of central bank independence by examining the impact of cohesive and role‐equivalent trade relationships between countries. They find support for their hypotheses with information on 71 countries between 1990 and 2000.
Die ZEW-Gründerstudie - Konzeption und Erhebung

Die vorliegende Arbeit beschreibt die Konzeption und Erhebung der ZEW-Grunderstudie. Bei dieser im Jahre 1999 am ZEW durchgefuhrten telefonischen Unternehmensbefragung wurde auf Basis der ZEW-Grundungspanels Ost und West eine geschichtete Stichprobe von 12.000 Unternehmen gezogen. Fur diese Unternehmen wurden sukzessive Unternehmensvertreter am Unternehmensstandort und ggf. Unternehmensbeteiligte kontaktiert. Die vorliegende Studie geht auf die Ziehung der Stichprobe, die Durchfuhrung der telefonischen Unternehmensbefragung sowie deren Ergebnisse ein.