Miracle-dz/UniFAR-FTUs huggingface dataset:
Life at the top: Lake ecotype influences the foraging pattern, metabolic costs and life history of an apex fish predator.

We used acoustic telemetry and acceleration sensors to compare population-specific measures of the metabolic costs of an apex fish predator living in four separate lakes. We chose our study species and populations to provide a strong test of recent theoretical predictions that optimal foraging by an apex fish predator in a typical aquatic environment would be consistent with feeding to satiation rather than continuous feeding. We chose four populations where the primary prey type differed along a body size gradient (from small invertebrates to large planktivorous fish) and along a thermal accessibility gradient (from easily accessible cold-water pelagic prey to less accessible warm-water epilimnetic and littoral prey). We expected that these gradients in prey type would evoke distinctly different activity gradients depending on whether predators fed to satiation (e.g., less frequent "rest" detections where primary prey are smaller/less accessible) or fed continuously (e.g., fixed level of "rest" detections under all prey conditions). Our study organism was a fall spawning, cold-water visual apex predator (lake trout). Therefore, we focused our study on diel (early night, dawn, day, dusk, late night) changes in metabolic costs associated with summer feeding behaviour. The duration (~20 days) and fine temporal scale (~30 min) of our behavioural data provided a uniquely detailed picture of intra- and inter-population differences in activity patterns over a critical period in the annual growing season. In all populations, diel shifts in activity were qualitatively consistent with that expected of a visual predator (e.g., resting state detections were most frequent at night). Between-lake differences in daytime thermal experience were qualitatively consistent with between-lake differences in the location of primary prey (e.g., excursions to warm habitats were common in lakes with epilimnetic/littoral fish as primary prey and relatively rare in lakes with pelagic cold-water invertebrates/fish as primary prey). Daytime activity patterns were more consistent with the feeding pattern expected from feeding to satiation rather than continuous feeding: (a) individuals in all four populations exhibited clearly delineated bouts of resting behaviour and active behaviour; (b) the frequency of resting bouts and the resultant overall cost of daily activity were strongly associated with the size and accessibility of prey-in lakes with smaller and/or less accessible prey, predators rested less frequently, exhibited marginally higher costs when active and had higher overall daytime activity costs. Within each lake, similar changes in activity occurred concurrently with diel changes in prey accessibility/relative density.
Online Subspace Learning from Gradient Orientations for Robust Image Alignment

Robust and efficient image alignment remains a challenging task, due to the massiveness of images, great illumination variations between images, partial occlusion, and corruption. To address these challenges, we propose an online image alignment method via subspace learning from image gradient orientations (IGOs). The proposed method integrates the subspace learning, transformed the IGO reconstruction and image alignment into a unified online framework, which is robust for aligning images with severe intensity distortions. Our method is motivated by a principal component analysis (PCA) from gradient orientations that provides more reliable low-dimensional subspace than that from pixel intensities. Instead of processing in the intensity-domain-like conventional methods, we seek alignment in the IGO domain, such that the aligned IGO of the newly arrived image can be decomposed as the sum of a sparse error and a linear composition of the IGO-PCA basis learned from previously well-aligned ones. The optimization problem is tackled by an iterative linearization that minimizes the $\ell _{1}$ -norm of the sparse error. Furthermore, the IGO-PCA basis is adaptively updated based on incremental thin singular value decomposition, which takes the shift of IGO mean into consideration. The efficacy of the proposed method is validated on the extensive challenging datasets through image alignment, medical atlas construction, and face recognition. The experimental results demonstrate that our algorithm provides more illumination- and occlusion-robust image alignment than the state-of-the-art methods.
Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction

Rationale: Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the key regulators that are responsible for maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) may confer vascular homeostasis and prevent aneurysmal disease. XBP1 (X-box binding protein 1), which exists in a transcriptionally inactive unspliced form (XBP1u) and a spliced active form (XBP1s), is a key component in response to endoplasmic reticular stress. Compared with XBP1s, little is known about the role of XBP1u in vascular homeostasis and disease. Objective: We aim to investigate the role of XBP1u in VSMC phenotypic switching and the pathogenesis of aortic aneurysms. Methods and Results: XBP1u, but not XBP1s, was markedly repressed in the aorta during the early onset of aortic aneurysm in both angiotensin II–infused apolipoprotein E knockout (ApoE−/−) and CaPO4 (calcium phosphate)-induced C57BL/6J murine models, in parallel with a decrease in smooth muscle cell contractile apparatus proteins. In vivo studies revealed that XBP1 deficiency in smooth muscle cells caused VSMC dedifferentiation, enhanced vascular inflammation and proteolytic activity, and significantly aggravated both thoracic and abdominal aortic aneurysms in mice. XBP1 deficiency, but not an inhibition of XBP1 splicing, induced VSMC switching from the contractile phenotype to a proinflammatory and proteolytic phenotype. Mechanically, in the cytoplasm, XBP1u directly associated with the N terminus of FoxO4 (Forkhead box protein O 4), a recognized repressor of VSMC differentiation via the interaction and inhibition of myocardin. Blocking the XBP1u–FoxO4 interaction facilitated nuclear translocation of FoxO4, repressed smooth muscle cell marker genes expression, promoted proinflammatory and proteolytic phenotypic transitioning in vitro, and stimulated aortic aneurysm formation in vivo. Conclusions: Our study revealed the pivotal role of the XBP1u–FoxO4–myocardin axis in maintaining the VSMC contractile phenotype and providing protection from aortic aneurysm formation.
Disagreement between high confidence endoscopic adenoma prediction and histopathological diagnosis in colonic lesions ≤ 3 mm in size

Abstract Background Diminutive colorectal polyps resected during colonoscopy are sometimes histologically interpreted as normal tissue. The aim of this observational study was to explore whether errors in specimen handling or processing account in part for polyps ≤ 3 mm in size being interpreted as normal tissue by pathology when they were considered high confidence adenomas by an experienced endoscopist at colonoscopy. Methods One endoscopist photographed 900 consecutive colorectal lesions that were ≤ 3 mm in size and considered endoscopically to be high confidence conventional adenomas. The photographs were reviewed blindly to eliminate poor quality images. The remaining 644 endoscopy images were reviewed by two external experts who predicted the histology while blinded to the pathology results. Results Of 644 consecutive lesions ≤ 3 mm in size considered high confidence conventional adenomas by a single experienced colonoscopist, 15.4 % were reported as normal mucosa by pathology. The prevalence of reports of normal mucosa in polyps removed by cold snare and cold forceps were 15.2 % and 16.0 %, respectively. When endoscopy photographs were reviewed by two blinded outside experts, the lesions found pathologically to be adenomas and normal mucosa were interpreted as high confidence adenomas by endoscopic appearance in 96.9 % and 93.9 %, respectively, by Expert 1 (P = 0.15), and in 99.6 % and 100 %, respectively, by Expert 2 (P = 0.51). Conclusion Retrieval and/or processing of tissue specimens of tiny colorectal polyps resulted in some lesions being diagnosed as normal tissue by pathology despite being considered endoscopically to be high confidence adenomas. These findings suggest that pathology interpretation is not a gold standard for lesion management when this phenomenon is observed.
High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo

Tumor cells utilize glucose to fuel their anabolic needs, including rapid proliferation. However, due to defective vasculature and increased glucose uptake, tumor cells must overcome glucose deprivation. Accordingly, tumor cells depend on cellular pathways promoting survival under such conditions. Targeting these survival mechanisms can thus serve as a new therapeutic strategy in oncology. As such, we sought to identify small-molecule inhibitors which sensitize tumor cells to glucose starvation by high-throughput drug screening in vitro. Specifically, we searched for inhibitors that selectively killed tumor cells growing in glucose-free but not in normal medium. This phenotypic drug screen of 7000 agents with MCF7 cells led to the identification of 67 potential candidates, 31 of which were validated individually. Among the identified compounds, we found a high number of compounds known to target mitochondria. The efficacies of two of the identified compounds, QNZ (EVP4593) and papaverine, were validated in four different tumor cell lines. We found that these agents inhibited the mTOR(Mechamistic\Mammilian Target of Rapamycin) pathway in tumor cells growing under glucose starvation, but not under normal conditions. The results were validated and confirmed in vivo, with QNZ and papaverine exhibiting superior antitumor activity in a tumor xenograft model when combined with the VEGF inhibitor bevacizumab (avastin). Administering these drug combinations (i.e., avastin and papaverine, and avastin and QNZ) led to significant reductions in proliferation and mTOR activity of the aggressive DLD1 colon cell line in mice. Given our findings, we propose that compounds targeting metabolically challenged tumors, such as inhibitors of mitochondrial activity, be considered as a therapeutic strategy in cancer.
Psychological distress among bariatric surgery candidates: The roles of body image and emotional eating

The increased risk of psychological distress among bariatric surgery candidates may be attributed, at least in part, to body image dissatisfaction (BID). The aim of the present study was to test the hypotheses that body image could be correlated with the psychological distress variables, and that emotional eating behaviours could mediate the relationship between body image and psychological distress. A sample of consecutive participants seeking bariatric surgery (N = 169, 67% females, mean age, 41.8 years [SD = 11.46], mean body mass index 42.0 kg/m2 [SD = 11.0]) was recruited from a university‐based bariatric centre, a week prior to scheduled surgery. Results showed that BID was positively correlated with suicidality (r = 0.18, P < 0.05), depression (r = 0.39, P < 0.01) and anxiety (r = 0.20, P < 0.05). The relation between BID and depression was partially mediated by emotional eating, whereas the relation between BID and suicidality was fully mediated by emotional eating. Physicians and other health professionals who treat bariatric surgery patients should be encouraged to detect behaviours indicating emotional eating, as these could be an indicator of psychological distress resulting from poor body image.
High-speed, low-power digital and analog circuits implemented in IBM SiGe BiCMOS technology

Under the auspices of Defense Advanced Research Project Agency Microsystems Technology Office (DARPA/MTO) Low Power Electronics Program, the Mayo Foundation is exploring ways to reduce circuit power consumption, while maintaining or increasing functionality, for existing military systems. Applications presently being explored by Mayo include all-digital radar receivers, electronic warfare receivers, and other types of digital signal processors. One of the integrated circuit technologies currently under investigation by Mayo to support such military systems is the IBM Corporation silicon germanium (SiGe) BiCMOS process. In this paper, design methodology and test results from demonstration circuits developed for these applications and implemented in the IBM SiGe BiCMOS technology are presented.
A Survey on Machine Learning-Based Mobile Big Data Analysis: Challenges and Applications

This paper attempts to identify the requirement and the development of machine learning-based mobile big data (MBD) analysis through discussing the insights of challenges in the mobile big data. Furthermore, it reviews the state-of-the-art applications of data analysis in the area of MBD. Firstly, we introduce the development of MBD. Secondly, the frequently applied data analysis methods are reviewed. Three typical applications of MBD analysis, namely, wireless channel modeling, human online and offline behavior analysis, and speech recognition in the Internet of Vehicles, are introduced, respectively. Finally, we summarize the main challenges and future development directions of mobile big data analysis.
Effort to perceive the position of one visual horizontal line relative to another appearing close causes an earlier postural response to backward perturbation

Humans make an effort to stabilize the body when a stable eye position is required to improve visibility. Perceiving the position of one visual object relative to another appearing close is relatively difficult compared with perceiving those objects appearing at a distance. Thus, humans must make an effort to stabilize their body to improve visibility when they attempt to perceive the position of one object relative to another appearing close. This process may enhance the response to postural perturbation. The present study tested this hypothesis. A total of 15 healthy participants maintained a position standing over the platform and gazed at a horizontal fixation line in front of them. One of the two warning sound cues was given in each trial; one predicted the forthcoming appearance of a horizontal line 2 mm above or below the horizontal fixation line (indistinct condition), and another predicted the forthcoming appearance of the horizontal line 2 cm above or 2 cm below the horizontal fixation line (distinct condition). After the warning sound cue, the support surface moved in the forward or backward direction. A horizontal line appeared 40 ms after the onset of the support surface motion at the level above or below the horizontal fixation line with the distance from the horizontal fixation line as the warning cue predicted. The participants verbally stated the position of the horizontal line relative to the horizontal fixation line after the offset of the support surface movement. The displacement of the head and sacrum was measured with acceleration sensors. A test of the simple main effect following an analysis of variance revealed that the peak downward displacement of the pelvis in the indistinct condition was significantly earlier than that in the distinct condition. This finding indicated that the effort to stabilize the body for improvement of visibility enhances the response of the pelvis to the forward movement of the support surface. This effect may be used for improvement of the postural response in patients with problems with postural control.
The neuroscience of morality and social decision-making

ABSTRACT Across cultures humans care deeply about morality and create institutions, such as criminal courts, to enforce social norms. In such contexts, judges and juries engage in complex social decision-making to ascertain a defendant’s capacity, blameworthiness, and culpability. Cognitive neuroscience investigations have begun to reveal the distributed neural networks which interact to implement moral judgment and social decision-making, including systems for reward learning, valuation, mental state understanding, and salience processing. These processes are fundamental to morality, and their underlying neural mechanisms are influenced by individual differences in empathy, caring and justice sensitivity. This new knowledge has important implication in legal settings for understanding how triers of fact reason. Moreover, recent work demonstrates how disruptions within the social decision-making network facilitate immoral behavior, as in the case of psychopathy. Incorporating neuroscientific methods with psychology and clinical neuroscience has the potential to improve predictions of recidivism, future dangerousness, and responsivity to particular forms of rehabilitation.
Enhanced non-linear optical properties of porphyrin-based polymers covalently functionalized with graphite phase carbon nitride

In our work, a flurry of original porphyrin-based polymers covalently functionalized g-C3N4 nanohybrids were constructed and nominated as PPorx-g-C3N4 (x = 1, 2 and 3) through click chemistry between porphyrin-based polymers with alkyne end-groups [(PPorx-C≡CH (x = 1, 2 and 3)] and azide-functionalized graphitic carbon nitride (g-C3N4-N3). Due to the photoinduced electron transfer (PET) between porphyrin-based polymers [PPorx (x = 1, 2 and 3)] group and graphite phase carbon nitride (g-C3N4) group in PPorx-g-C3N4 nanohybrids, the PPorx-g-C3N4 nanohybrids exhibited better non-linear optical (NLO) performance than the corresponding PPorx-C≡CH and g-C3N4-N3. It found that the imaginary third-order susceptibility (Im [χ(3)]) value of the nanohybrids with different molecular weight (MW) of the pPorx group in the nanohybrids ranged from 2.5×103 to 7.0 × 103 g mol−1 was disparate. Quite interestingly, the Im [χ(3)] value of the nanohybrid with a pPorx group’s MW of 4.2 × 103 g mol−1 (PPor2-g-C3N4) was 1.47 × 10–10 esu, which exhibited the best NLO performance in methyl methacrylate (MMA) of all nanohybrids. The PPorx-g-C3N4 was dispersed in polymethyl methacrylate (PMMA) to prepare the composites PPorx-g-C3N4/PMMA since PMMA was widely used as an alternative to glass. PPor2-g-C3N4/PMMA showed the excellent NLO performance of all nanohybrids with the Im [χ(3)] value of 2.36 × 10–10 esu, limiting threshold of 1.71 J/cm2, minimum transmittance of 8% and dynamic range of 1.09 in PMMA, respectively. It suggested that PPorx-g-C3N4 nanohybrids were potential outstanding NLO materials.
A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol Levels

Cholesterol homeostasis is maintained through a balance of de novo synthesis, intestinal absorption, and excretion from the gut. The small intestine contributes to cholesterol homeostasis by absorbing and excreting it, the latter of which is referred to as trans-intestinal cholesterol efflux (TICE). Because the excretion efficiency of endogenous cholesterol is inversely associated with the development of atherosclerosis, TICE provides an attractive therapeutic target. Thus, elucidation of the mechanism is warranted. We have shown that intestinal cholesterol absorption and TICE are inversely correlated in intestinal perfusion experiments in mice. In this review, we summarized 28 paired data sets for absorption efficiency and fecal neutral sterol excretion, a surrogate marker of TICE, obtained from 13 available publications in a figure, demonstrating the inverse correlation were nearly consistent with the assumption. We then offer a bidirectional flux model that accommodates absorption and TICE occurring in the same segment. In this model, the brush border membrane (BBM) of intestinal epithelial cells stands as the dividing ridge for cholesterol fluxes, making the opposite fluxes competitive and being coordinated by shared BBM-localized transporters, ATP-binding cassette G5/G8 and Niemann-Pick C1-like 1. Furthermore, the idea is applied to address how excess plant sterol/stanol (PS) intake reduces circulating cholesterol level, because the mechanism is still unclear. We propose that unabsorbable PS repeatedly shuttles between the BBM and lumen and promotes concomitant cholesterol efflux. Additionally, PSs, which are chemically analogous to cholesterol, may disturb the trafficking machineries that transport cholesterol to the cell interior.
Jumping Asymmetries Are Associated With Speed, Change of Direction Speed, and Jump Performance in Elite Academy Soccer Players

Abstract Bishop, C, Brashill, C, Abbott, W, Read, P, Lake, J, and Turner, A. Jumping asymmetries are associated with speed, change of direction speed, and jump performance in elite academy soccer players. J Strength Cond Res 35(7): 1841–1847, 2021—The aim of this study was to establish interlimb asymmetries across different age groups in elite academy male soccer players and to examine any relationships between asymmetry and measures of physical performance. Fifty-one players from an English Premier League soccer academy were split into under-23 (n = 21), under-18 (n = 14), and under-16 (n = 16) groups and performed bilateral and unilateral countermovement jumps, 5-, 10-, and 20-m sprints, and a 505 change of direction speed tests. All tests showed low variability (coefficient of variation ≤ 2.5%) and good to excellent reliability (intraclass correlation coefficient = 0.80–0.99). A 1-way analysis of variance showed that the under-23 group was significantly faster than the under-16 group during the 20-m sprint (2.90 vs. 2.98 s; p = 0.02; effect size = 0.94). No other significant differences were present between groups. Interlimb asymmetry was quantified from the single-leg countermovement jump, and no significant differences in the magnitude of asymmetry were present between groups. However, multiple significant correlations were present in each age group between asymmetry and physical performance tests, all of which were indicative of reduced athletic performance. Results from this study show that although interlimb asymmetry scores are comparable across age groups in elite academy soccer players, differences as low as 5% are associated with reduced physical performance during jumping, sprinting, and change of direction speed tasks. This study suggests the importance of monitoring jump height asymmetries in elite academy soccer players.