Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioinformatics analysis of the regulatory lncRNA-miRNA-mRNA network and drug prediction in patients with hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a complex inherited cardiovascular disease. The present study investigated the long noncoding (lnc)RNA/microRNA (mi)RNA/mRNA expression pattern of patients with HCM and aimed to identify key molecules involved in the development of this condition. An integrated strategy was conducted to identify differentially expressed miRNAs (DEmiRs), differentially expressed lncRNAs (DElncs) and differentially expressed genes (DEGs) based on the GSE36961 (mRNA), GSE36946 (miRNA), GSE68316 (lncRNA/mRNA) and GSE32453 (mRNA) expression profiles downloaded from the Gene Expression Omnibus datasets. Bioinformatics tools were employed to perform function and pathway enrichment analysis, protein-protein interaction, lncRNA-miRNA-mRNA and hub gene networks. Subsequently, DEGs were used as targets to predict drugs. The results indicated that a total of 2,234 DElncs (1,120 upregulated and 1,114 downregulated), 5 DEmiRs (2 upregulated and 3 downregulated) and 42 DEGs (35 upregulated and 7 downregulated) were identified in 4 microarray profiles. Gene ontology analysis revealed that DEGs were mainly involved in actin filament and stress fiber formation and in calcium ion binding, whereas Kyoto Encyclopedia of Genes and Genomes pathway analysis identified the hypoxia inducible factor-1, transforming growth factor-β and tumor necrosis factor signaling pathways as the main pathways involved in these processes. The hub genes were screened using cytoHubba. A total of 1,086 lncRNA-miRNA-mRNA interactions including 67 lncRNAs, 5 miRNAs and 25 mRNAs were mined in the present study based on prediction websites. Drug prediction indicated that the targeted drugs mainly included angiotensin converting enzyme inhibitors or β-blockers. A comprehensive bioinformatics analysis of the molecular regulatory lncRNA-miRNA-mRNA network was performed and potential therapeutic applications of drugs were predicted in HCM patients. The data may unravel the future molecular mechanism of HCM.
Cross-hedging and forward-contract pricing of electricity in the Pacific Northwest

This paper develops a linear regression model for using actively traded NYMEX natural gas futures as a cross-hedge against electricity spot-price risk in the Pacific Northwest and for pricing the forward contracts in the presence of temperature and hydro risks. Our approach comports with reality and provides power purchasers with an effective instrument through which they can hedge their electricity bets through natural gas futures. It also demonstrates the sharp month-to-month variations in the natural gas futures' optimal hedge ratios and hedge effectiveness. Finally, it finds significant risk premiums in the Pacific Northwest forward prices, supporting the hypothesis that forward-contract buyers are relatively more risk-averse than sellers. Copyright © 2011 John Wiley & Sons, Ltd.
Efficient combination of multi-user MIMO THP and user selection based on spatial orthogonality

This paper proposes an efficient method for combing multi-user MIMO (MU-MIMO) employing Tomlinson Harashima precoding (THP) with semiorthogonal user selection (SUS). Although the ordering of MU-MIMO THP and SUS create space diversity benefit and multi-user diversity benefit, respectively, a significant computational effort is required, which is expected to be relaxed while retaining the system level performance. The proposed method is inspired by the fact that the ordering calculations of MU-MIMO THP and SUS are commonly based on the spatial orthogonality. If that is the case, the result of the ordering of SUS is fully reused for the ordering of MU-MIMO THP, which can eliminate the calculation process of the ordering of MU-MIMO THP. The effectiveness of the proposed method is demonstrated in comparison with the traditional method with the ordering of MU-MIMO THP by means of computer simulations.
THE MORAVA K-THEORY AND BROWN-PETERSON COHOMOLOGY OF SPACES RELATED TO BP

We calculate the Morava K-theory of the spaces in the Omega spectra for BP 〈q〉. They fit into an exotic array of short and long exact sequences of Hopf algebras. We apply this to calculate the p-adically completed Brown-Peterson cohomology, as well as all of the intermediary cohomology theories, E, of these spaces. We give two descriptions of the answer, both of which turn out to be surprisingly nice. One part of our first description is just the image in the E cohomology of the corresponding space in the Omega spectrum for BP , which is as big as it could possibly be and which we show how to calculate. The other part is just the E cohomology of several copies of Eilenberg-MacLane spaces, something which is already known. Our second description is inductive and gives us a new way of looking at the Brown-Peterson cohomology of Eilenberg-Mac Lane spaces. The Brown-Comenetz dual of BP 〈q〉 shows up in our calculations and so we take up the study of this spectrum as well. It was already known that the Morava K-theory of the spaces in the Omega spectrum for the Brown-Comenetz dual of BP 〈q〉 made it look like a product of Eilenberg-Mac Lane spaces and we find, somewhat to our surprise, that the same is true for the BP cohomology. In order to state our answers we set up the foundations for the category of completed Hopf algebras.
Correlati on of Acousti c Cues i n Stop Producti ons of Korean and Engli sh Adults and Chi ldren

Previous studies have investigated a between-category relationship of multiple acoustic cues for a laryngeal contrast by examining the distributions of VOT, f0 and H1-H2. The current study examined within-category correlations between cues comprising stops by Koreanand English-speaking adults and children to understand how children master the internal structure of stop phonation types in two languages. Word-initial stops were collected from about 70 children and 15 adults speaking English and Korean, and were analyzed in terms of VOT, f0 and H1-H2 to compute correlation coefficients. Findings in adults’ productions included a gender-differentiated cue-correlation pattern associated with H1-H2 in Korean tense stops and a trading relationship between f0 and VOT in Korean lax and aspirated stops and English voiced and voiceless stops. Children did not necessarily have adult-like cue-correlation patterns even in early-acquired categories, suggesting that the mastery of intra-category structure of phonation type might occur later than inter-category structure.
Development of a Descriptive Model of Flow Disruption Effect on Bypass Time in a Cardiovascular Operating Room

16 Acknowledgements: . 18 Acronyms: . 20 Chapter 1: Introduction . 22 Forward . 22 Medical Human Factors Overview . 23 Cardiovascular Operating Room: . 26 Team Members: . 26 Bypass Time: . 28 Flow Disruptions: . 29 RIPCHORD-TWA Taxonomy: . 31 Weaknesses in Current Methodology: . 34 Error Space: . 36 Flow Disruptions as Threats . 36 Conceptualization: . 37 Purpose of Current Research . 39 Preceding Studies: . 40 Medical University of South Carolina: . 40 Florida Hospital: . 41 CVOR Descriptive Model 5 Chapter 2: Preliminary Analysis . 42 Data Available . 42 Normalized Data: . 42 Concept Visualization . 43 Power Laws . 43 Prism Diagrams . 44 Heat Maps . 45 Correlational Development . 46 Correlational Testing . 53 Three-Dimensional Correlational Mapping . 59 Other Preliminary Analysis . 62 Next Steps . 63 Chapter 3: Model Theory . 64 Overview of Mathematical Modeling . 64 Control Theory . 64 Markovian Chain . 64 Similar Research: . 67 Research Questions: . 69 Model Design . 72 Breakdown by Role.73 Interaction of Roles . 74 Breakdown by Major Category . 76 CVOR Descriptive Model 6 Methodology to be Employed . 76 Chapter 4: Model Development and Testing . 80 Procedural Modeling . 80 Mathematical Modeling . 86 Final Mathematical Model . 89 Peripheral Task Absorbsion Factor . 92 True Data Inclusion.93 Visual Modeling . 94 Image Models . 94 Video Models . 97 Chapter 5: Results . 98 Overall Results . 98 Breakdown by Team Member . 104 Anesthesia Role . 105 Circulating Nurse Role . 107 Perfusionist Role . 110 Surgical Role . 113 Breakdown by RIPCHORD-TWA Category . 116 Communication . 116 Coordination . 118 Equipment Issues . 121 CVOR Descriptive Model 7 Interruptions . 122 Layout . 124 Usability . 127 Results Summary . 128 Chapter 6: Discussion and Conclusions . 129 CVOR Flow Disruptions . 129 General Analysis . 130 Error Space . 131 Modeling . 133 Breakdown by Team Member . 134 Interaction between Team Members . 136 Breakdown by Major Category . 138 CVOR State Interpretation . 140 Interventions . 143 Communication . 143 Coordination . 146 Equipment Issues . 148 Interruptions . 149 Layout . 151 Usability . 153 Conclusions . 154 CVOR Descriptive Model 8 Recommendations for Future Research . 156 Limitations and Delimitations . 157 Limitations . 157 Delimitations . 158 Chapter 7: Supporting Information . 1600 References: . 1600 Appendix A -Complete RIPCHORD Taxonomy: . 1700 Appendix B – Visual Depiction of CVOR Data .
Religious Doubt, Depressive Symptoms, and Rumination at an Advanced Age

Individuals in late adulthood are often confronted with difficulties and challenges that elicit existential questions and doubts, including religious doubts. Although research has shown that unresolved religious doubts increase the risk for depression, it remains unclear how they are related to each other in late adulthood and which mechanisms are underlying this relationship. Therefore, in a longitudinal study of 329 older adults aged 65-99 and living in a nursing home, the relation between religious doubt and depressive symptoms was explored as well as the mediation effect of rumination on this relationship. The results confirmed the relation between religious doubt and the experience of depressive symptoms, with a bidirectional influence over time. However, the findings indicated that this reciprocal relationship was not mediated by rumination. The study highlights the importance of identifying older adults who experience religious doubt and who are at risk for or suffer from depressive symptoms.
Evaluation of the lard oxidative stability added with rosemary extract and rosemary essential oil

The production of undesirable compounds from oxidative processes in oils and fats is a problem when it comes to extending shelf life or deep-fat frying foods. In this work the use of rosemary extract and rosemary essential oil in the lard submitted to thermoxidation was evaluated and compared with the synthetic antioxidant TBHQ.The extract obtained from solvent extraction and the rosemary essential oil were submitted to free radical analysis DPPH • and ABTS •+ , total phenolic compounds and total flavonoids. The lard was divided into four treatments: lard (control), lard + 100 mg kg -1 TBHQ (L + TBHQ), lard + 100 mg kg -1 rosemary extract (L + RE) and lard + 100 mg kg -1 rosemary essential oil (L + REO). The treatments were submitted to thermoxidation at 180°C, where samples were taken off at intervals of 0, 5, 10, 15 and 20 hours. The samples were analyzed for free fatty acid content, peroxide index and conjugated dienes. The extract showed better antioxidant potential when compared to the essential oil (15.20 and 18.51 mg mL -1 for EC 50 ; 917.87 and 321.71 μmol ET mL -1 , respectively). The analysis for total phenolics compounds and total flavonoids showed no statistical difference (99.55 and 80.88 mg EAG L -1 ; 29.79 and 31.42 μg ER mL -1 , respectively). During the analysis of the thermoxidated lard, the rosemary essential oil showed results as favorable as those obtained by the antioxidant TBHQ, showing that the antioxidants from natural source can be a good alternative to synthetics ones.
3-D Reconstruction of Objects Using Digital Fringe Projection: Survey and Experimental Study

Three-dimensional reconstruction of small objects has been one of the most challenging problems over the last decade. Computer graphics researchers and photography professionals have been working on improving 3D reconstruction algorithms to fit the high demands of various real life applications. Medical sciences, animation industry, virtual reality, pattern recognition, tourism industry, and reverse engineering are common fields where 3D reconstruction of objects plays a vital role. Both lack of accuracy and high computational cost are the major challenges facing successful 3D reconstruction. Fringe projection has emerged as a promising 3D reconstruction direction that combines low computational cost to both high precision and high resolution. It employs digital projection, structured light systems and phase analysis on fringed pictures. Research studies have shown that the system has acceptable performance, and moreover it is insensitive to ambient light. This paper presents an overview of fringe projection approaches. It also presents an experimental study and implementation of a simple fringe projection system. We tested our system using two objects with different materials and levels of details. Experimental results have shown that, while our system is simple, it produces acceptable results.
cRacle: R tools for estimating climate from vegetation

Premise of the study The Climate Reconstruction Analysis using Coexistence Likelihood Estimation (CRACLE) method for the estimation of climate from vegetation is a robust set of modeling tools for estimating climate and paleoclimate that makes use of large repositories of biodiversity data and open-access R software. Methods Here we implement a new R library for the estimation of climate from vegetation.The ‘cRacle’ library implements functions for data access, aggregation, and models to estimate climate from plant community composition. ‘cRacle’ is modular and features many best-practice features. Results Performance tests using modern vegetation survey data from North and South America shows that CRACLE outperforms alternative methods. CRACLE estimates of mean annual temperature (MAT) are usually within 1°C of the actual when optimal model parameters are used. Generalized Boosted Regression (GBR) model correction is also shown here to improve on CRACLE models by reducing bias. Discussion CRACLE provides accurate estimates of climate from modern plant communities. Non-parametric CRACLE modeling coupled to GBR model correction produces the most accurate results to date. The ‘cRacle’ R library streamlines the estimation of climate from plant community data, and will make this modeling more accessible to a wider range of users.
Metabolic Architecture of the Deep Ocean Microbiome

The deep sea, the largest compartment of the ocean, is an essential component of the Earth system, but the functional exploration of its microbial communities lags far behind that of other marine realms. Here we analyze 58 bathypelagic microbial metagenomes from the Atlantic, Indian, and Pacific Oceans in an unprecedented sampling effort from the Malaspina Global Expedition, to resolve the metabolic architecture of the deep ocean microbiome. The Malaspina Deep-Sea Gene Collection, 71% of which consists of novel genes, reveals a strong dichotomy between the functional traits of free-living and particle-attached microorganisms, and shows relatively patchy composition challenging the paradigm of a uniform dark ocean ecosystem. Metagenome Assembled Genomes uncovered 11 potential new phyla, establishing references for deep ocean microbial taxa, and revealed mixotrophy to be a widespread trophic strategy in the deep ocean. These results expand our understanding of the functional diversity, metabolic versatility, and carbon cycling in the largest ecosystem on Earth. One Sentence Summary A whole community genomic survey of the deep microbiome sheds light on the microbial and functional diversity of the dark ocean.
Effect of Organizational Culture and Staff Competence on the Implementation of Credit Scoring at Kenya Women Fund Trust

Credit scoring is a scientific method of assessing the credit risk associated with new credit applications. The implementation of credit scoring programs/projects in a microfinance environment is difficult and has encountered poor implementation outcomes. Insufficient volume of micro finance applications encountered, does not allow most lenders to develop their own scorecards using their own data and thus many microfinance institutions do not track applications because of insufficient systems to develop an elaborate scoring process. The study sought to investigate the effect of organizational culture and staff competence on the implementation of credit scoring at Kenya Women Fund Trust (KWFT). The target population was over 1,500 Business Development Officers and Credit Risk Managers who were working at KWFT of which 125 respondents were selected using random sampling approach. Data was collected using the questionnaire and analyzed using descriptive statistic. Correlation analysis and a multiple linear regression analysis model was used to establish the relationship between organization culture, staff competences and the implementation of credit scoring. The study found that organizational culture, staff competence were positively and significantly related with and implementation of credit scoring. The study concluded that Organizational culture and Staff competence influenced the implementation of credit scoring at KWFT. The study recommended for an effective use of the organizational culture and staff capacity since they were helpful in guiding the design, implementation and management of the credit scoring system through its various development stages in a microfinance environment. Keywords: Organizational culture, Staff competence, Credit scoring, and Kenya Women Microfinance Bank
The role of sport organizations for local and national community – the case of Sámi sport organizations

ABSTRACT Research question: This paper investigates (1) how representatives of Sámi sport clubs understand local and national communities, and (2) and the role of the sport organization in the creation and perception of local and national community. The study contributes to the research field by showing how sport organizations are the basis of the community, locally and nationally. Research methods: Interviews were conducted with seven board members representing five Sámi sport clubs in four municipalities. The sport clubs were all members of the Sámi sport organization, and located in core Sámi areas where Sámi language and culture is manifested in everyday life. Sámi are the indigenous peoples of the northern Norway, Sweden, Finland and north-west Russia. Results and findings: For sport club representatives, Sámi sport refers to specific activities associated with Sámi husbandry heritage, and to the Sámi sport organization. Sport clubs function as community organizations at the local level. Moreover, through affiliation with the Sámi sport organization, the sport clubs are the link to the Sámi national community. Sámi indigeneity is played out internally in the local community as well as on the borderline to other communities with other ethnic compositions. Implications: The study revealed a complex relationship between the local and national elements of indigeneity, and between the internal and the external elements. These elements of multiculturalism and sport clubs require to be taken into account in future sport management and policy-making in addition to multicultural policies towards immigrant sport participation and organization.
Bacterial Isolates and Drug Susceptibility Pattern of Sterile Body Fluids from Tertiary Hospital, Northern Ethiopia: A Four-Year Retrospective Study

This study was conducted in Ayder comprehensive specialized Hospital, Mekelle, Northern Ethiopia, to determine the bacterial profiles and drug susceptibility pattern from body fluids. A total of 218 patients were investigated, of which 146 (67%) were males. The age of the study subjects ranged from 2 days to 80 years with 96(44%) in the age group of 15 years and above. The overall bacterial infection was 44 (20.2 %) of which gram positive bacteria were prevalent, 23 (52.3%) than gram negative bacteria 21 (47.7%). The predominantly isolated bacteria were S. pneumonia, followed by K.pneumoniae, S. aureus, and E coli. Multidrug resistance was observed in 12 (100%) of the isolated gram positive bacteria and in 6 (75%) of the isolated gram negative bacteria.
28-GHz CMOS VCO With Capacitive Splitting and Transformer Feedback Techniques for 5G Communication

This paper presents a 28-GHz low phase noise voltage-controlled oscillator (VCO) in a 65-nm CMOS process for 5G communication applications. With the capacitive splitting and transformer feedback techniques, theoretical analysis and simulations are undertaken for the proposed oscillator, proving that its negative $G_{m}$ can be enhanced over the interested frequency range and reduced at the harmonic frequencies. Moreover, the proposed oscillator startup performance is analyzed, and its tank quality factor, transient and phase noise performance are simulated. With 4-bit switch capacitors and varactors, the proposed VCO achieves a tuning range from 25.7 to 29.7 GHz, consuming 10.8 mW from a 0.9-V supply voltage. With a wideband common-source buffer, the output signal power is around 1 dBm. At 26.5 GHz, the proposed VCO achieves low phase noise of −105.8 dBc/Hz at 1-MHz offset and −130 dBc/Hz at the 10-MHz offset, respectively.
In Proceedings of ACM SIGCOMM Comparison of Rate Based Service Disciplines

This paper compares six new queue service disciplines that can be implemented at the output queues of switches in a connection oriented packet switched data network These are Virtual Clock Fair Queueing Delay Earliest Due Date Jitter Earliest Due Date Stop and Go and Hierarchi cal Round Robin We describe their mechanisms their sim ilarities and di erences and some implementation strate gies In particular we show why each discipline can or can not provide bandwidth delay and delay jitter guarantees This leads to some interesting conclusions about the rela tive strengths and weaknesses of each approach
Epigenetic regulation underlying Plasmodium berghei gene expression during its developmental transition from host to vector

Epigenetic regulation of gene expression is an important attribute in the survival and adaptation of the malaria parasite Plasmodium in its human host. Our understanding of epigenetic regulation of gene expression in Plasmodium developmental stages beyond asexual replication in the mammalian host is sparse. We used chromatin immune-precipitation (ChIP) and RNA sequencing to create an epigenetic and transcriptomic map of the murine parasite Plasmodium berghei development from asexual blood stages to male and female gametocytes, and finally, to ookinetes. We show that heterochromatin 1 (HP1) almost exclusively associates with variantly expressed gene families at subtelomeric regions and remains stable across stages and various parasite lines. Variant expression based on heterochromatic silencing is observed only in very few genes. In contrast, the active histone mark histone 3 Lysine 9 acetylation (H3K9ac) is found between heterochromatin boundaries and occurs as a sharp peak around the start codon for ribosomal protein genes. H3K9ac occupancy positively correlates with gene transcripts in asexual blood stages, male gametocytes and ookinetes. Interestingly, H3K9ac occupancy does not correlate with transcript abundance in female gametocytes. Finally, we identify novel DNA motifs upstream of ookinete-specific genes thought to be involved in transcriptional activation upon fertilization.