Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Photoinduced Energy and Electron Transfer in ZnII -Porphyrin/Fullerene Dyads with Interchromophoric Distances up to 2.6 nm and No Wire-like Connectivity.

The dyads 1-3 made of an alkynylated ZnII -porphyrin and a bis-methanofullerene derivative connected through a copper-catalyzed azide-alkyne cycloaddition have been synthesized. The porphyrin and fullerene chromophores are separated through a bridge made of a bismethanofullerene tether linked to different spacers conjugated to the porphyrin moiety [i.e., m-phenylene (1), p-phenylene (2), di-p-phenylene-ethynylene (3)]. Compounds 1-3 exhibit relatively rigid structures with an interchromophoric separation of 1.7, 2.0, and 2.6 nm, respectively, and no face-to-face or direct through-bond conjugation. The photophysical properties of compounds 1-3 have been investigated in toluene and benzonitrile with steady-state and time-resolved techniques as well as model calculations on the Förster energy transfer. Excited-state interchromophoric electronic interactions are observed with a distinct solvent and distance dependence. The latter effect is evidenced in benzonitrile, where compounds 1 and 2 exhibit a photoinduced electron transfer in the Marcus-inverted region, with charge-separated (CS) states living for 0.44 and 0.59 μs, respectively, whereas compound 3 only undergoes energy transfer, as in apolar toluene. The quantum yield of the charge separation (φCS ) of compounds 1 and 2 in benzonitrile is ≥0.75. It is therefore demonstrated that photoinduced energy and electron transfers in porphyrin-fullerene systems with long interchromophoric distances may efficiently occur also when the bridge does not provide a wire-like conjugation and proceed through the triplet states of the chromophoric moieties.
Timing of morphological and ecological innovations in the cyanobacteria – a key to understanding the rise in atmospheric oxygen

When cyanobacteria originated and diversified, and what their ancient traits were, remain critical unresolved problems. Here, we used a phylogenomic approach to construct a well‐resolved ‘core’ cyanobacterial tree. The branching positions of four lineages (Thermosynechococcus elongatus, Synechococcus elongatus, Synechococcus PCC 7335 and Acaryochloris marina) were problematic, probably due to long branch attraction artifacts. A consensus genomic tree was used to study trait evolution using ancestral state reconstruction (ASR). The early cyanobacteria were probably unicellular, freshwater, had small cell diameters, and lacked the traits to form thick microbial mats. Relaxed molecular clock analyses suggested that early cyanobacterial lineages were restricted to freshwater ecosystems until at least 2.4 Ga, before diversifying into coastal brackish and marine environments. The resultant increases in niche space and nutrient availability, and consequent sedimentation of organic carbon into the deep oceans, would have generated large pulses of oxygen into the biosphere, possibly explaining why oxygen rose so rapidly. Rapid atmospheric oxidation could have destroyed the methane‐driven greenhouse with simultaneous drawdown in pCO2, precipitating ‘Snowball Earth’ conditions. The traits associated with the formation of thick, laminated microbial mats (large cell diameters, filamentous growth, sheaths, motility and nitrogen fixation) were not seen until after diversification of the LPP, SPM and PNT clades, after 2.32 Ga. The appearance of these traits overlaps with a global carbon isotopic excursion between 2.2 and 2.1 Ga. Thus, a massive re‐ordering of biogeochemical cycles caused by the appearance of complex laminated microbial communities in marine environments may have caused this excursion. Finally, we show that ASR may provide an explanation for why cyanobacterial microfossils have not been observed until after 2.0 Ga, and make suggestions for how future paleobiological searches for early cyanobacteria might proceed. In summary, key evolutionary events in the microbial world may have triggered some of the key geologic upheavals on the Paleoproterozoic Earth.
Bacterial and iron oxide aggregates mediate secondary iron mineral formation: green rust versus magnetite

In the presence of methanoate as electron donor, Shewanella putrefaciens, a Gram‐negative, facultative anaerobe, is able to transform lepidocrocite (γ‐FeOOH) to secondary Fe (II–III) minerals such as carbonated green rust (GR1) and magnetite. When bacterial cells were added to a γ‐FeOOH suspension, aggregates were produced consisting of both bacteria and γ‐FeOOH particles. Recently, we showed that the production of secondary minerals (GR1 vs. magnetite) was dependent on bacterial cell density and not only on iron reduction rates. Thus, γ‐FeOOH and S. putrefaciens aggregation pattern was suggested as the main mechanism driving mineralization. In this study, lepidocrocite bioreduction experiments, in the presence of anthraquinone disulfonate, were conducted by varying the [cell]/[lepidocrocite] ratio in order to determine whether different types of aggregate are formed, which may facilitate precipitation of GR1 as opposed to magnetite. Confocal laser scanning microscopy was used to analyze the relative cell surface area and lepidocrocite concentration within the aggregates and captured images were characterized by statistical methods for spatial data (i.e. variograms). These results suggest that the [cell]/[lepidocrocite] ratio influenced both the aggregate structure and the nature of the secondary iron mineral formed. Subsequently, a [cell]/[lepidocrocite] ratio above 1 × 107 cells mmol−1 leads to densely packed aggregates and to the formation of GR1. Below this ratio, looser aggregates are formed and magnetite was systematically produced. The data presented in this study bring us closer to a more comprehensive understanding of the parameters governing the formation of minerals in dense bacterial suspensions and suggest that screening mineral–bacteria aggregate structure is critical to understanding (bio)mineralization pathways.
Association of renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study

Objective The renin–angiotensin system and endothelial function have both been associated with hypertension. The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin–angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension. Methods We analyzed data from 18 436 Caucasian women who participated in a prospective cohort study and were free of hypertension at baseline. Six previously characterized single nucleotide polymorphisms (NOS3 rs1800779, NOS3 rs3918226, NOS3 rs1799983, ACE rs1799752, AGT rs699, and AGTR1 rs5186) were genotyped. Blood pressure progression at 48 months and incident hypertension during the entire follow-up according to the different genotypes and inferred haplotypes were assessed by logistic regression and Cox proportional hazards models, respectively. Results At 48 months, 47.4% of the women had blood pressure progression. The odds ratios (95% confidence intervals) for blood pressure progression associated with NOS3 rs1800779, NOS3 rs3918226, NOS3 rs1799983, ACE rs1799752, AGT rs699, and AGTR1 rs5186 were 1.00 (0.96–1.05), 1.00 (0.92–1.09), 0.99 (0.94–1.04), 0.96 (0.92–1.01), 1.04 (0.99–1.08), and 1.03 (0.98–1.08), respectively. During 9.8 years of follow-up, 29.6% of women developed incident hypertension. The hazard ratios (95% confidence interval) for the six polymorphisms were 1.01 (0.97–1.06), 1.06 (0.99–1.14), 1.05 (1.01–1.09), 0.99 (0.95–1.02), 1.01 (0.97–1.05), and 0.99 (0.95–1.04). NOS3 haplotypes were not significantly associated with blood pressure progression (P = 0.91) or incident hypertension (P = 0.10). Conclusion Blood pressure progression and incident hypertension are not consistently associated with six well-characterized genetic polymorphisms of the renin–angiotensin system and the NOS3 gene in a large cohort of Caucasian women.
THE RELATIONSHIP BETWEEN HAND GRIP STRENGTH AND HAND BONE MINERAL DENSITY IN CHILDREN WITH INSULIN DEPENDENT DIABETES MELLITUS

We thought that grip strength in patients with IDDM would be associated with hand BMD of patients and we thought that patients with IDDM have lower hand BMD than normal subjects.Therefore in this study, the evaluation of the relationship between hand grip strength and hand bone mineral density in healthy children and in children with insulin dependent diabetes mellitus was studied. The hand grip strength, hand and axial bone mineral density of patients were also compared to age-matched healthy controls. We studied 31 consecutive outpatients with insulin dependent diabetes mellitus defined in accordance to the World Health Organization criteria, who attended to the diabetic outpatient clinic. Thirty two healthy children were included as control group. There were no differences in the age, body mass index, bone age, serum Ca and P levels between the diabetic patients and the controls (p > 0.05). There were no significant differences between the groups in hand grip strength, total hand and axial bone mineral density (p > 0.05). There were significant correlations between hand grip strength and hand bone mineral density r = 0.824, p = 0.000), axial bone mineral density (r = 0.714, p = 0.000), bone age (r = 0.830, p = 0.000) and duration of insulin dependent diabetes mellitus in the diabetic group (r = 0.463, p = 0.009). When linear multiple regression analysis was performed hand grip strength and bone age were independent predictors of hand BMD (p < 0.05). We found that hand grip strength significantly correlated with the hand and axial bone mineral density in patients with insulin dependent diabetes mellitus. We suggest that strengthening exercises should be encouraged to increase bone mineral density in these patients.
Angiotensin II receptor blockers and myocardial infarction: an updated analysis of randomized clinical trials

Objective To evaluate the effects of treatments based on angiotensin II receptor blockers (ARBs) on the risk of myocardial infarction (MI), cardiovascular and all-cause death, as compared with conventional treatment or placebo. Methods We performed a meta-analysis of all available major international, randomized clinical trials (20 trials, n = 108 909 patients, mean age 66.5 ± 4.1 years), published by 31 August 2008, comparing ARBs with other drugs or conventional therapies (placebo) and reporting MI incidence. Results During a mean follow-up of 3.3 ± 1.1 years, a total of 2374/53 208 and 2354/53 153 cases of MI were recorded in ARB-based groups and in comparator arms, respectively [odds ratio (OR) 95% confidence interval (CI) 1.008 (0.950–1.069)]. Risks of MI were not different when tested in different clinical conditions, including hypertension, high cardiovascular risk, stroke, coronary disease, renal disease and heart failure. No significant differences in the risk of MI between treatment with ARBs versus placebo [OR 95% CI 0.944 (0.841–1.060)], beta-blockers and diuretics [OR 95% CI 0.970 (0.804–1.170)], calcium channel blockers [OR 95% CI 1.112 (0.971–1.272)], or angiotensin-converting enzyme (ACE) inhibitors [OR 95% CI 1.008 (0.926–1.099)] were observed. Analysis of trials comparing combination therapy based on ARBs plus ACE inhibitors versus active treatments or placebo showed equivalent MI risk [OR 95% CI 0.996 (0.896–1.107)]. Conclusion The present meta-analysis indicates that the risk of MI is comparable with use of ARBs and other antihypertensive drugs in a wide range of clinical conditions.
Elucidation of Dual Magnetic Relaxation Processes in Dinuclear Dysprosium(III) Phthalocyaninato Triple-Decker Single-Molecule Magnets Depending on the Octacoordination Geometry.

When applying single-molecule magnets (SMMs) to spintronic devices, control of the quantum tunneling of the magnetization (QTM) as well as a spin-lattice interactions are important. Attempts have been made to use not only coordination geometry but also magnetic interactions between SMMs as an exchange bias. In this manuscript, dinuclear dysprosium(III) (DyIII ) SMMs with the same octacoordination geometry undergo dual magnetic relaxation processes at low temperature. In the dinuclear DyIII phthalocyaninato (Pc2- ) triple-decker type complex [(Pc)Dy(ooPc)Dy(Pc)] (1) (ooPc2- =2,3,9,10,16,17,23,24-octakis(octyloxy)phthalocyaninato) with a square-antiprismatic (SAP) geometry, the ground state is divided by the Zeeman effect, and level intersection occurs when a magnetic field is applied. Due to the ground state properties of 1, since the Zeeman diagram where the levels intersect in an Hdc of 2500 Oe, two kinds of QTM and direct processes occur. However, dinuclear DyIII -Pc systems with C4 geometry, which have a twist angle (ϕ) of less than 45° do not undergo dual magnetic relaxation processes. From magnetic field and temperature dependences, the dual magnetic relaxation processes were clarified.
Importance of pulsatility in hypertensive carotid artery growth and remodeling

Arteries experience marked variations in blood pressure and flow during the cardiac cycle that can intensify during exercise, in disease, or with aging. Diverse observations increasingly suggest the importance of such pulsatility in arterial homeostasis and adaptations. We used a transverse aortic arch banding model to quantify chronic effects of increased pulsatile pressure and flow on wall morphology, composition, and biaxial mechanical properties in paired mouse arteries: the highly pulsatile right common carotid artery proximal to the band (RCCA-B) and the nearly normal left common carotid artery distal to the band (LCCA-B). Increased pulsatile mechanical stimuli in RCCA-B increased wall thickness compared with LCCA-B, which correlated more strongly with pulse (r* = 0.632; P < 0.01) than mean (r* = 0.020; P = 0.47) or systolic (r* = 0.466; P < 0.05) pressure. Similarly, inner diameter at mean pressure increased in RCCA-B and correlated slightly more strongly with a normalized index of blood velocity pulsatility (r* = 0.915; P < <0.001) than mean flow (r* = 0.834; P < 0.001). Increased wall thickness and luminal diameter in RCCA-B resulted from significant increases in cell number per cross-sectional area (P < 0.001) and collagen-to-elastin ratio (P < 0.05) as well as a moderate (1.7-fold) increase in glycosaminoglycan content, which appears to have contributed to the significant decrease (P < 0.001) in the in-vivo axial stretch in RCCA-B compared with LCCA-B. Changes in RCCA-B also associated with a signficant increase in monocyte chemoattractant protein-1 (P < 0.05) whereas LCCA-B did not. Pulsatile pressure and flow are thus important stimuli in the observed three-dimensional arterial adaptations, and there is a need for increased attention to the roles of both axial wall stress and adventitial remodeling.
Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness

Background Arterial stiffness is an important risk factor for cardiovascular disease. Carotid-femoral pulse wave velocity (cfPWV) is the most recognized and established index of arterial stiffness. An emerging automatic measure of PWV primarily used in the Asian countries is brachial-ankle PWV (baPWV). Method To systematically compare these two methodologies, we conducted a multicenter study involving a total of 2287 patients. Results There was a significant positive relation between baPWV and cfPWV (r = 0.73). Average baPWV was approximately 20% higher than cfPWV. Both cfPWV and baPWV were significantly and positively associated with age (r = 0.56 and 0.64), systolic blood pressure (r = 0.49 and 0.61), and the Framingham risk score (r = 0.48 and 0.63). The areas under the receiver operating curves (ROCs) of PWV to predict the presence of both stroke and coronary artery disease were comparable between cfPWV and baPWV. Conclusion Collectively, these results indicate that cfPWV and baPWV are indices of arterial stiffness that exhibit similar extent of associations with cardiovascular disease risk factors and clinical events.
A Highly Sensitive Bimodal Detection of Amine Vapours Based on Aggregation Induced Emission of 1,2-Dihydroquinoxaline Derivatives.

The detection of food spoilage is a major concern in food safety as large amounts of food are transported globally. Direct analysis of food samples is often time-consuming and requires expensive analytical instrumentation. A much simpler and more cost-effective method for monitoring food fermentation is to detect biogenic amines generated as a by-product during food decomposition. In this work, a series of 1,2-dihydroquinoxaline derivatives (DQs) with aggregation-induced emission (AIE) characteristics were synthesised and their protonated forms, that is, H+ DQs, can be utilised for the sensitive detection of biogenic amines. For example, upon exposure to amine vapours, deprotonation occurs that converts the red-coloured, non-emissive H+ DQ2 back to its yellow-coloured, fluorescent parent form. The bimodal absorption and emission changes endow the system with high sensitivity, capable of detecting ammonia vapour at a concentration of as low as 690 ppb. Taking advantage of this, H+ DQ2 was successfully applied for the detection of food spoilage and was established as a robust and cost effective technique to monitor food safety.
Evaluation method of product–service performance

In order to analyse product–service performance (PSP) during product–service systems' (PSSs) running time, a PSP evaluation method is proposed. Interrelationship between a PSS's provider and accepter is defined as product–service relationship (PSR). Concepts of product–service network and product–service chain are put forward to describe interrelationship among PSRs from different perspectives. The concept of PSP is proposed to evaluate interrelationship among PSR. Detailed evaluation indexes are designed to measure the five factors of PSP, including time, quality, cost, stability and reliability. A case study is provided to test the validity and efficiency of the evaluation model of PSP. The analysis results show that the evaluation model can make good efforts in benefiting product–service platform's running, monitoring and optimising.
Case studies on collaboration, technology and performance factors in business networks

This paper presents part of the findings of a research project aiming at characterising high-performance collaborative business networks and at defining the conditions required for their creation and management. The project adopted a multiple case study research strategy and three different business networks are presented in this paper. Empirical studies have been performed in Northern Portugal. The results of the study include operational definitions based on a comprehensive literature review, a conceptual reference framework for the analysis of high-performance collaborative networks and recommendations for the creation and management of such networks.
Risk Factors for Hospital Admission in Elderly Public Housing Tenants

To identify potential risk factors for hospital admission, we interviewed elderly (range: 62-94; mean = 74.6 years) public housing tenants using a broad-based assessment instrument. Persons reporting more depressive symptoms, worse physical health, and decreased ability to perform physical self-maintenance activities were hospitalized nearly twice as frequently in the one year subsequent to the baseline interview. We conclude that traditional health status measures are better predictors of hospital admissions than social factors. By identifying high-risk patients, health care professionals may be able to intervene in the outpatient setting to reduce patients' use of expensive inpatient care.
Disproportionally impaired microvascular structure in essential hypertension

Background Increased microvascular resistance and small artery remodelling are key abnormalities in the pathophysiology of essential hypertension. We investigated the relation between the impairment of coronary and forearm minimum vascular resistances (C-Rmin and F-Rmin) and the degree of hypertension. Method Seventy-five never-treated essential hypertension patients with 24-h systolic blood pressure (BP) at least 130 mmHg or diastolic BP at least 80 mmHg were assigned into grade 1 (office BP 140/90–159/99 mmHg) and grade 2 (office BP 160/100–179/109 mmHg) hypertension and compared to normotensive controls (n = 25). The patients were (48 years, 60% men) without cardiovascular disease. C-Rmin and coronary flow reserve (CFR) were derived from flow measurements in the left anterior descending artery using transthoracic echocardiography. F-Rmin was measured using venous occlusion plethysmography. Resting systemic vascular resistance index (SVRI) was measured with a gas rebreathing technique. Results Compared to normotensive controls: 24-h mean BP was raised 14% in grade 1 essential hypertension and 28% in grade 2 essential hypertension, whereas F-Rmin and C-Rmin were elevated by 58 and 87% in grade 1 essential hypertension and 72 and 125% in grade 2 essential hypertension. C-Rmin and F-Rmin were thus both increased more than expected from the BP level. SVRI and left-ventricular mass were increased proportionally to the BP. CFR was decreased by approximately 30% in both essential hypertension groups. Conclusion The results demonstrate excessive microvascular structural abnormalities in hypertension suggesting microvascular alterations occur early and not just as an adaptation to the BP level. Thus the level of BP elevation does not give an accurate indication of the microvascular involvement and impairment in essential hypertension.
Combining multi-agent model, SOA and ontologies in a distributed and interoperable architecture to manage multi-site production projects

Today, production projects are often achieved by multi-site production and the associated markets become more and more dynamic and service oriented. In this context, the multi-site project management is a difficult task, which has to take into account not only the decision distribution and the information confidentiality, but also the heterogeneity existing between different production management systems used by partners. The generic planning model SCEP (supervisor, customer, environment, producer) based on multi-agent technology offers a well-adapted solution to the decision distribution and information confidentiality in project management. SCEP was integrated with ontological mechanisms and SOA (service-oriented architecture) components in a new architecture Semantic-SCEPSOA, which makes it possible to achieve a distributed and interoperable management of multi-site production projects. In the case of two sites managed by two different planning software applications, the semantic interoperability effectiveness is shown within the S-SCEPSOA architecture.