Miracle-dz/UniFAR-FTUs huggingface dataset:
Environmental and Genetic Regulation of Plant Height in 1 Soybean 2

7 Background: 8 Shoot architecture is fundamentally crucial to crop growth and productivity. As a key component of 9 shoot architecture, plant height is known to be controlled by both genetic and environmental factors, 10 though specific details remain scarce. Results: In this study, 308 representative soybean lines from a core collection and 168 F 9 soybean progeny 13 were planted at distinct field sites. The results demonstrated the presence of significant genotype × 14 environment interaction (G × E) effects on traits associated with plant height in a natural soybean 15 population. In total, 19 loci containing 51 QTLs (quantitative trait locus) for plant height were 16 identified across four environments, with 23, 13 and 15 being QTLs for SH (shoot height), SNN 17 (stem node number) and AIL (average internode length), respectively. Significant LOD ranging 18 from 2.50 to 16.46 explained 2.80% - 26.10% of phenotypic variation. Intriguingly, only two loci, 19 Loc11 and Loc19-1 , containing 20 QTLs, were simultaneously detected across all environments. 20 Results from Pearson correlation analysis and PCA (principal component analysis) revealed that 21 each of the five agro-meteorological factors and four soil properties significantly affected soybean 22 plant height traits, and that the corresponding QTLs had additive effects. Among significant 23 environmental factors, AD (average day-length), AMaT (average maximum temperature), pH, and 24 AN (available nitrogen) had the largest impacts on soybean plant height. Therefore, in spite of 25 uncontrollable agro-meteorological factors, soybean shoot architecture might be remolded through 26 combined efforts to produce superior soybean genetic materials while also optimizing soil properties. Overall, the set of relationships outlined herein among environment factors, soybean genotypes and QTLs in effects on plant height opens new avenues to explore in work aiming to increase soybean yield through improvements in shoot architecture.
Search of Categorized Internet Content based on Consumption analysis in the social network of a user

: In Today’s World, the consumption of internet content has increased manifold. The number of people as well as number of websites has increased exponentially. Therefore there is a big need for performing a consumption analysis of this internet consumption. There are various applications to track this consumption at individual levels, but none to do it for a closed group like a family or a class or a project team. Our work proposes an application which not only tracks the internet consumption of the individuals but also collaborates it for a social group and displays the summary in a categorical format. Such an application will club the internet content visited and consumed by a group of people connected together by their own choice and categorizes the recorded data into various heads based on type as well as level. The result of this application can be customized on the basis of inputs given by a user, providing a very crisp summary which has a plethora of practical advantages to various sections of society.
Antigen Presentation to Cytotoxic T Cells Vectors Enhances Transgene-Encoded Subgroup B Fiber-Modified Adenovirus Monocyte-Derived Dendritic Cells with Highly Efficient Transduction of Human

The efﬁciency of dendritic cells (DC) as immunotherapeutic vaccines critically depends on optimal delivery of target Ags. Although DC modiﬁed by subgroup C type 5 recombinant adenoviruses (rAd5) provide encouraging results, their clinical application is hampered by the need for high viral titers to achieve sufﬁcient gene transfer, due to the lack of the Ad5 ﬁber receptor. We now demonstrate that rAd5 carrying subgroup B Ad ﬁbers are up to 100-fold more potent than classical rAd5 for gene transfer and expression in human DC, rAd5 with a type 35 ﬁber (rAd5F35) being the most efﬁcient vector. This improvement relates to a greater and faster virus entry and to an increased transgene expression especially following DC maturation. Furthermore, these new vectors possess enhanced synergistic effects with other activation signals to trigger DC maturation. Consequently, rAd5F35-infected DC engineered to express the gp100 melanoma-associated Ag largely exceed rAd5-infected DC in activating gp100-speciﬁc CTL. Finally, the DC infection pattern of rAd5F35 is fully conserved when DC are in the vicinity of primary skin-derived ﬁbroblasts, suggesting this vector as a candidate for in vivo targeting of DC. Thus, subgroup B ﬁber-modiﬁed rAd5 constitute a major breakthrough in the exploitation of ex vivo rAd-targeted DC as clinically relevant vaccines and may also be suitable for in vivo genetic modiﬁcation of DC. The Journal of Immunology, 2001, 166: 5236–5244.
Developing Sustainable Business Models to Connect, Upskill and Enhance the Collaborative Capabilities of Europe’s SMEs in Open Innovation; the Case of OI2Lab.

The Horizon2020 project “INVITE: Co-designing and piloting demand-driven mechanisms, skill - sets and measures for stimulating and facilitating open innovation across European innovation systems”, aims at creating a well-connected cross-regional open innovation ecosystem. In this paper we present the services and business models that are being co-developed and improved for OI2 Lab, the multisided platform of INVITE that aims to stimulate open innovation, especially small and medium sized enterprises. We set out by presenting the relevant literature, focusing particularly on the online and offline dimentions of open innovation, as well as the role of small and medium sized enterprises. For the development of the business models for OI2 Lab, the Business Model Canvas for demand-driven value proposition design was used, complimented by a co-creation workshop and a series of interviews. In its present form, OI2 Lab offers four distinct services, while the three business models that were initally developed have now converged into one. During the forthcoming stages of INVITE, these business models will be validated and improved again in order to increase prospects for sustainability and market success. Developing Sustainable Business Models to Connect, Upskill and Enhance the Collaborative Capabilities of Europe’s SMEs in Open Innovation; the Case of OI2Lab.
A CROSS-SECTIONAL COMPARATIVE RESEARCH ON THE DIFFERENCE OF DENGUE FEVER (DF) AND DENGUE HEMORRHAGIC FEVER (DHF) WITH ITS SEVERITY GRADES (DHF I, II, III & IV)

: Objectives: Our research aimed at the determination of the difference between dengue hemorrhagic fever (DHF) and dengue fever (DF) total cholesterol (TC) including adverse DHF III & IV and favorable DHF I & II outcomes. Methodology: Our research was a cross-sectional comparative study which was carried out from July – November, 2017 in the Medicine Department of Services Hospital, Lahore. The sample of the research was one hundred febrile cases diagnosed with positive serology of dengue. We measured every case for TC on the first day of admission. Clinical outcomes of DHF and DF were also measured. Classification was made as DHF cases were divided into favorable and adverse groups respectively I, II and II, IV on the basis of their outcomes. Results: Male to female proportion was respectively 64 & 36 with a mean age and TC respectively as (33.03 ± 14.5) years and (3.02 ± 0.88) mmol/L. Mean age of the 63 DF cases and 37 DHF cases were respectively (30.21 ± 12.7) & (37.84 ± 16.21) with a significant P-value as ((0.017) and values of mean TC for both respectively as (3.43 ± 0.79) & (2.34 ± 0.56) mmol/L with a significant P-value as (0.000). Male to female proportion in DF was two to one and in DHF cases it was 1.47 to one (p = 0.001). In the total 37 DHF cases the further subdivision was as that DHF I, II, III and IV cases were respectively 16, 8, 10 and 3cases. Mean TC for DHF I (2.77 ± 0.45), DHF II (2.16 ± 0.33), DHF III (2.05 ± 0.35) and DHF IV (1.49 ± 0.35) mmol/L. Respective favorable and adverse outcomes of the mean TC were level were (2.55 ± 0.5) & (1.92 ± 0.42) mmol/l with significant P-value as (0.000). Conclusion: There is a strong correlation of low TC serum with the severity of the disease in the patients of dengue fever.
CCL17Production of the Chemokines CCL1 and T Cell Activation through the + CD8IL-12 Produced by Dendritic Cells Augments

IL-12 family members are an important link between innate and adaptive immunity. IL-12 drives Th1 responses by augmenting IFN- (cid:2) production, which is key for clearance of intracellular pathogens. IL-23 promotes the development of IL-17-producing CD4 (cid:1) T cells that participate in the control of extracellular pathogens and the induction of autoimmunity. However, recent studies have shown that these cytokines can modulate lymphocyte migration and cellular interactions. Therefore, we sought to determine the individual roles of IL-12 and IL-23 in naive CD8 (cid:1) T cell activation by addressing their ability to inﬂuence IFN- (cid:2) production and cellular interaction dynamics during priming by Listeria monocytogenes -infected dendritic cells (DC). We found that IL-12 was the major cytokine inﬂuencing the level of IFN- (cid:2) production by CD8 (cid:1) T cells while IL-23 had little effect on this response. In addition, we observed that IL-12 promoted longer duration conjugation events between CD8 (cid:1) T cells and DC. This enhanced cognate interaction time correlated with increased production of the chemokines CCL1 and CCL17 by WT but not IL-12-deﬁcient DC. Neutralization of both chemokines resulted in reduced interaction time and IFN- (cid:2) production, demonstrating their importance in priming naive CD8 (cid:1) T cells. Our study demonstrates a novel mechanism through which IL-12 augments naive CD8 (cid:1) T cell activation by facilitating chemokine production, thus promoting more stable cognate interactions during priming. The Journal of Immunology, 2008, 181: 8576–8584. presentation capacity of all DC was determined by an OVA-spe-ciﬁc T cell hybridoma, B3Z, following listerial infection. We observed similar levels of costimulatory molecule up-regulation and Ag presentation by Lm-infected WT, p35 (cid:2) / (cid:2) , and p40 (cid:2) / (cid:2) DC (data not shown). IL-12 promotes long duration interactions between CD8 (cid:1) Lm-infected
Design of ECG Acquisition System and Noise Removal Using MSP 430 Controller

In today’s world, electrocardiography (ECG) is very important to detect heart related problems. Many technologies have been developed for medical monitoring. In this study, we are developing monitoring system using 3 leads. This system takes input as an analog signal processes and conditions it and converts it into digital signal. After converting, it processes the digital signal with MSP430 controller.
Use of Artificial Intelligence in Smart Cities for Smart Decision-Making: A Social Innovation Perspective

The goal of this study is to investigate the direct and indirect relationships that exist between artificial intelligence (AI), social innovation (SI), and smart decision-making (SDM). This study used a survey design and collected cross-sectional data from South Korea and Pakistan using survey questionnaires. Four hundred sixty respondents from the public and private sectors were obtained and empirically analyzed using SPSS multiple regression. The study discovered a strong and positive mediating effect of SI between the relationship of AI and SDM, as predicted. Previous researchers have investigated some of the factors that influence the decision-making process. This study adds to the social science literature by examining the impact of a mediating factor on decision-making. The findings of this study will contribute to the local government in building smart cities such that the factor of social innovations should be involved in the decision-making process because smart decision-making would share such collected data with entrepreneurs, businesses, and industries and would benefit society and all relevant stakeholders, including such social innovators.
Human Decidual Macrophages Expressed by Clostridium sordellii for Structure, Is the Major Phagocytic Receptor Macrophage Receptor with Collagenous The Class A Scavenger Receptor,

Clostridium sordellii is an emerging pathogen associated with highly lethal female reproductive tract infections following childbirth, abortion, or cervical instrumentation. Gaps in our understanding of the pathogenesis of C. sordellii infections present major challenges to the development of better preventive and therapeutic strategies against this problem. We sought to determine the mechanisms whereby uterine decidual macrophages phagocytose this bacterium and tested the hypothesis that human decidual macrophages use class A scavenger receptors to internalize unopsonized C. sordellii . In vitro phagocytosis assays with human decidual macrophages incubated with pharmacological inhibitors of class A scavenger receptors (fucoidan, polyinosinic acid, and dextran sulfate) revealed a role for these receptors in C. sordellii phagocytosis. Soluble macrophage receptor with collagenous structure (MARCO) receptor prevented C. sordellii internalization, suggesting that MARCO is an important class A scavenger receptor in decidual macrophage phagocytosis of this microbe. Peritoneal macrophages from MARCO-deﬁcient mice, but not wild-type or scavenger receptor AI/II–deﬁcient mice, showed impaired C. sordellii phagocytosis. MARCO-null mice were more susceptible to death from C. sordellii uterine infection than wild-type mice and exhibited impaired clearance of this bacterium from the infected uterus. Thus, MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus. The Journal of Immunology , 2010, 185: 000–000.
DSCTP Congestion Control Algorithm Based on Dynamic Policies

—This paper introduces DSCTP (Dynamic Stream Control Transmission Protocol), a sender-side, transport-layer protocol that modifies the standard Stream Control Transmission Protocol (SCTP) protocol. Although SCTP provides support for multi-homing ， the basic reason for such a provision was to improve reliability of associations, simultaneous transfer of new data to multiple paths is currently not allowed in SCTP. DSCTP adopts SCTP’s multi-homing feature to distribute data across multiple end-to-end paths in a multi-homed SCTP association. DSCTP aims at exploiting congestion control algorithm of Transmission Control Protocol (TCP) and SCTP. Through the use of dynamic policy management framework, DSCTP switches the transmission onto the alternate path using DSCTP’s flexible path management capabilities. We can gain significant throughput improvement if simultaneously transfer new data across multiple paths to the receiver. In this article ， these techniques include transmission start, flow control, network monitoring, generation of policies, routing switching, and congestion recovery. Extensive simulations under different scenarios highlight the superiority of the proposed solution with respect to TCP and the standard SCTP implementation.
NEXUS : LIVE NOTATION AS A HYBRID COMPOSITION AND PERFORMANCE TOOL

The NEXUS live notation system, the latest product of the Hayden-Kanno collaboration, contrasts with their previ-ous projects which utilised live DSP and synthesis. NEXUS is first discussed in the contexts of a comparison of Kanno’s experience of performing solo violin works in-volving the live generation of music in both the audio and symbolic domains, and the affordances of Common Prac-tice Notation for generative music. As with previous Hay-den-Kanno projects, the main goal is the creation of a mu-sical work which is fluid and spontaneous, both in its global form and specifics of detail, yet maintains a sonic consistency and coherence, but now in the symbolic do-main. The implications of performer reading and interpre-tation for system design are explored. The second half of the paper outlines the main functions of the Max patch, how GMN code is generated for rendering as CPN in IN-Score during the performance, and, of the performer GUI which constrains the stochastic processes underlying the generation of specific musical parameters, general textual characteristics, and global formal shaping . The challenge was to formalize Hayden’s compositional procedures so the generated notations retain a musical identity and in-terest, whilst leaving space for Kanno’s interpretative de-cisions and being technically simple enough to be sight-readable. The uses of the system for hybrid performance and compositional applications are discussed, and some directions for future development.
Rapid generation of combined CMV-specific CD4 + and CD8 + T-cell lines for adoptive transfer into allogeneic stem cell transplant recipients

Adoptive transfer of cytomegalovirus-specific T-cells can restore long lasting virus-specific immunity and clear CMV-viremia in allogeneic stem cell transplant (SCT) recipients, if both CD4 + and CD8 + CMV-specific T-cells are detected in the recipient after transfer. Current protocols for generating virus-specific T-cells utilize live virus, require leukapheresis of donor and remains time consuming. To circumvent these limitations, a clinical scale protocol was developed for generation of CMV-specific T-cells by utilizing autologous cellular and serum components derived from one single 500mL blood draw. CMV-specific T-cells were stimulated simultaneously with CMV-specific MHC-I restricted peptides and CMV-antigen. Activated T-cells were isolated with the interferon- (cid:1) secretion assay and expanded for 10 days. In 8 randomly selected CMV-seropositive donors on average 1.34x10 8 combined CD4 + and CD8 + CMV-specific T-cells were generated as determined by antigen-triggered interferon- (cid:1) production. CMV-infected fibroblasts were efficiently lysed by the generated T-cells and CMV-specific CD4 + and CD8 + T-cells expanded if stimulated with natural processed antigen. On the other hand, CD4 + and CD8 + T-cell mediated alloreactivity of generated CMV-specific T-cell lines was reduced when compared to the starting population. In conclusion, the developed culture system allows rapid generation of allo-depleted and highly enriched combined CD4 + and CD8 + CMV-specific T-cells under good manufactoring practice conditions. staining, expansion upon restimulation, cytotoxicity assay and assessment of alloreactivity .
Combining resonance energy transfer methods reveals a complex between the (cid:1) 2A -adrenergic receptor, G (cid:1) i1 (cid:2) 1 (cid:3) 2 , and GRK2

Traditionally, G-protein-coupled receptor (GPCR) interactions with their G proteins and regulatory proteins, GPCR kinases (GRKs) and arrestins, are described as sequential events involving rapid assemblies/disassemblies. To directly monitor the dynamics of these interactions in living cells, we combined two spectrally resolved bioluminescence and one ﬂuorescence resonance energy transfer (RET) methods. The RET combination analysis revealed that stimulation of the (cid:1) 2A -adrenergic receptor ( (cid:1) 2A AR) leads to the recruitment of GRK2 at a receptor still associated with the G (cid:1) i1 (cid:2) 1 (cid:3) 2 complex. The interaction kinetics of GRKs with G (cid:3) 2 (2.8 (cid:4) 0.4 s) and (cid:1) 2A AR (5.2 (cid:4) 0.5 s) were similar to that of the receptor-pro-moted change in RET between G (cid:1) i1 and G (cid:3) 2 (5.2 (cid:4) 1.2 s), and persisted until the translocation of (cid:2) arrestin2 to the receptor, indicating that GRK2 remains associated to the receptor/G-protein complex for longer periods than anticipated. Moreover, GRK2 or a kinase-deﬁcient GRK2 mutant, but not GRK5, potentiated the receptor-promoted changes in RET between G (cid:1) i1 and G (cid:3) 2 and abrogated the (cid:1) l of the lysis buffer provided by the manufacturer, and freeze-thawed for com- plete lysis. Cell lysates were then transferred to an AlphaPlate 384SW plate, and 6 (cid:5) l of a solution containing the reaction buffer, activation buffer, and donor and acceptor beads was added. After overnight incubation, the AlphaScreen (chemi-luminescence) signal was measured using an (cid:1) -Fusion microplate reader (PerkinElmer).
DehydrogenasePromoting Optimal Expression of Retinal Activity in Dendritic Cells through Cutting Edge: 4-1BB Controls Regulatory

Dendritic cells (DC) in the gut promote immune tolerance by expressing retinal dehydrogenase (RALDH), an enzyme that promotes retinoic acid, which aids differentiation of Foxp3 + inducible regulatory T cells (iTreg) in the intestinal mucosa. How RALDH expression is regulated is unclear. We found that 4-1BB (CD137), a member of the TNFR family, together with CD103, marked mesenteric lymph node DC with the highest level of RALDH activity, and ligation of 4-1BB maintained RALDH expression in these gut DC. Moreover, 4-1BB signals synergized with those through TLR2 or GM-CSFR to promote RALDH activity in undifferentiated DC. Correspondingly, 4-1BB– deﬁcient mice were impaired in their ability to generate iTreg in the GALT when exposed to oral Ag, and 4-1BB–deﬁcient mesenteric lymph node DC displayed weak RALDH activity and were poor at promoting iTreg development. Thus, our data demonstrate a novel activity of 4-1BB in controlling RALDH expression and the regulatory activity of DC. The Journal of Immunology , 2012, 189: 000–000.
An Indole-3-Acetic Acid Carboxyl Methyltransferase Regulates Arabidopsis Leaf Development W

Auxin is central to many aspects of plant development; accordingly, plants have evolved several mechanisms to regulate auxin levels, including de novo auxin biosynthesis, degradation, and conjugation to sugars and amino acids. Here, we report the characterization of an Arabidopsis thaliana mutant, IAAcarboxyl methyltransferase1-dominant ( iamt1-D ), which displayed dramatic hyponastic leaf phenotypes caused by increased expression levels of the IAMT1 gene. IAMT1 encodes an indole-3-aceticacid(IAA)carboxylmethyltransferasethatconvertsIAAtomethyl-IAAester(MeIAA)invitro,suggestingthatmethylation of IAA plays an important role in regulating plant development and auxin homeostasis. Whereas both exogenous IAA and MeIAA inhibited primary root and hypocotyl elongation, MeIAA was much more potent than IAA in a hypocotyl elongation assay,indicatingthatIAAactivitiescouldbeeffectivelyregulatedbymethylation. IAMT1 wasspatiallyandtemporallyregulated during the development of both rosette and cauline leaves. Changing expression patterns and/or levels of IAMT1 often led to dramatic leaf curvature phenotypes. In iamt1-D , the decreased expression levels of TCP genes, which are known to regulate leaf curvature, may partially account for the curly leaf phenotype. The identiﬁcation of IAMT1 and the elucidation of its role in Arabidopsis leaf development have broad implications for auxin-regulated developmental process.