Miracle-dz/UniFAR-FTUs huggingface dataset:
DEEP VENOUS THROMBOSIS IN LOWER LIMBS, USING CRITERIA WELLS ET AL. (2003), D-DIMER, DUPLEX AND EVALUATION OF C-REACTIVE PROTEIN

Deep vein thrombosis (DVT) is common and important cause of morbidity- mortality, presenting Potentially fatal complications such as pulmonary thromboembolism. Diagnosis is one of the most problematic aspects. The disease signs and Symptoms are non-specific, complementary exams must be Performed to confirm diagnosis and start of anticoagulant treatment. To evaluate the efficacy of the Wells et al. Protocol (2003) and D Dimer test (DD) the diagnostic methods for DVT Compared to Duplex Mapping (DM) and analyze changes in C-reactive protein (CRP) Compared to DD. We selected 203 Patients with signs and Symptoms suggesting DVT. After being Submitted to anamnesis and general physical examination to fill out the Wells et al. evaluation protocol card and collection of material is DD and CRP measurements, pacientes Were submit test to DM to confirm or exclude DVT. There Were the significant differences between gender and age in the groups. The Wells protocol is a good predictive exam. DD presented high efficacy of the diagnosis method, useful for excluding DVT and CRP levels did not present any relationship with DD levels.
Bunching phase and constraints on echo enabled harmonic generation

A simple mathematical description is developed for the bunching spectrum in echo enabled harmonic generation (EEHG) that incorporates the eﬀect of additional electron beam energy modulations. Under common assumptions, they are shown to contribute purely through the phase of the longitudinal bunching factor, which allows the spectral moments of the bunching to be calculated directly from the known energy modulations. In particular, the second moment (spectral bandwidth) serves as simple constraint on the amplitude of the energy modulations to maintain a transform-limited seed. We show that, in general, the impact on the spectrum of energy distortions that develop between the EEHG chicanes scales like the harmonic number compared to distortions that occur upstream. This may limit the parameters that will allow EEHG to reach short wavelengths in high brightness FELs.
Report on MEMS Realisation/testing

MEMS based electron optics are a promising approach for a new generation of experiments in electron microscopy. In this contribution we improve analytically the modelling of the MEMS based phase plates with thin electrodes with accurate account of the fringing fields. As a result we are able to improve the design and the boundary conditions in MEMS-based spiral phase plates acting on the control parameters. We checked the quality of the generated vortex beam.
Waveform design method under dual constraints for radar imaging

This study focuses on the cognitive waveform optimisation for radar imaging. Classical cognitive waveform optimisation methods could degrade the point spread function and affect the imaging quality. To achieve high imaging quality, a waveform optimisation method maximising the receiving signal-to-clutter ratio under dual constraints including transmitting energy constraint and range profile constraint is designed. The proposed method is based on the response power ratio between a target and clutter, without the requirement of the precise prior knowledge about target and clutter response models. Combined with the shadow ghost mitigation in the through-wall-imaging radar (TWIR) imaging application, implementation of the proposed method is discussed. Simulations predict the performance of the proposed method, and through-wall imaging experiments were conducted, employing an ultra-wideband stepped frequency continuous waveform TWIR, and indicate that the proposed method can efficiently suppress the shadow ghosts in radar images, and simultaneously guarantee the imaging quality.
Co-occurrence of aggressive behavior and depressive symptoms in early adolescence: A longitudinal multi-informant study (cid:2)

Introduction. – Aggressive behavior and depressive symptoms co-occur frequently during adolescence. The failure model argues that the onset of aggressive behavior is more likely to precede the onset of depressive symptoms, whereas the acting-out model states that depressed mood predicts subsequent aggressive behavior. However, few longitudinal studies have examined with fully recursive models the temporal ordering of aggressive behavior and depressive symptoms during early adolescence. Objective. – Therefore, this study examined the bidirectional associations between aggressive behavior and depressive symptoms during early adolescence, using a multi-informant cross-lagged panel model. Gender differences were also investigated. Method. – We used data from three waves of questionnaire data that were annually collected among 497 early adolescents (56.9% boys) and their parents, thereby covering an age range from 12 to 15. Adolescents reported on their depressive symptoms and the parents reported on the adolescents’ aggressive behavior. Results. – Cross-lagged path analyses showed that early adolescents’ aggressive behavior predicted subsequent depressive symptoms, but early adolescents’ depressive symptoms did not predict aggressive behavior. Findings were similar for boys and girls. aggressive the start of adolescence the risk for subsequent depressive symptoms. Méthode. – Les données proviennent de questionnaires, colligées sur trois années consécutives, de 497 adolescents (56,9 % garc¸ ons ; âgés de 12 à 15 ans) et de leurs parents. Les symptômes dépressifs étaient évalués par l’adolescent lui-même, alors que les conduites agressives étaient évaluées par les parents. Résultats. – Des analyses acheminatoires ont montré que les conduites agressives des adolescents prédisent signiﬁcativement les symptômes dépressifs ultérieurs. La relation inverse n’est toutefois pas signiﬁcative. Les modèles ne semblent pas différer selon le sexe. Discussion. – Ces résultats apportent du soutien au modèle « échec » . Le fait de réduire les comporte- ments agressifs au début de l’adolescence pourrait aider à réduire le risque de symptômes dépressifs subséquents.
Developmental Expression of Spl in the Mouse

The expression of the trans-acting transcription factor Spl in mice was defined by a combination of RNA analysis and immunohistochemical localization of the Spl protein. Although ubiquitously expressed, there was an unexpected difference of at least 100-fold in the amount of Spl message in different cell types. Spl protein levels showed corresponding marked differences. Substantial variations in Spl expression were also found in some cell types at different stages of development. Spl levels appeared to be highest in developing hematopoietic cells, fetal cells, and spermatids, suggesting that an elevated Spl level is associated with the differentiation process. These results indicate that Spl has a regulatory function in addition to its general role in the transcription of housekeeping genes. The control of transcription is a key step in the regulation of gene expression. Although specific DNA elements around and within a gene contain the information directing this regulation, proteins that recognize these DNA sequences are the factors actually responsible for modulating RNA polymerase activity. Several sequence-specific DNA-binding transcription factors that are involved the process of
Robust model predictive control of HVAC systems with uncertainty in building parameters using linear matrix inequalities

ABSTRACT In this work, a new robust controller is proposed for building climate control in presence of parametric uncertainties. The design of the controller is based on the Model Predictive Control (MPC) framework and it includes time-varying constraints. The robust design is implemented by explicitly considering parametric uncertainty in the synthesis of the control law. Variations of the parameters of the buildings are represented in the form of polytopic uncertainty. The robust control action is obtained by minimizing an appropriate ‘worst-case’ cost function, which leads to the definition of a min–max optimization problem. This optimization problem is formulated using Linear Matrix Inequalities (LMIs) that allow for efficient numerical computation of the control command. Simulation results show that the proposed approach is successful in keeping the indoor temperature of the building in the desired range even in presence of large model uncertainties. The proposed controller is also compared with a nominal controller synthesized without accounting for parametric uncertainty. Numerical results confirm 24% better performance of the robust design in comparison with the nominal controller with same conditions. Further, simulation results also demonstrate that the robust control system achieves 17% better performance in the case of severe conditions of uncertainty.
DIFFERENTIAL INTERACTION OF HMG-CoA REDUCTASE INHIBITORS WITH ABCB1, ABCC2, AND OATP1B1

The present study examined the interaction of four 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (atorvastatin, lovastatin, and simvastatin in acid and lactone forms and pravastatin in acid form only) with multidrug resistance gene 1 (MDR1, ABCB1) P-glycoprotein, multidrug resistance associated protein 2 (MRP2, ABCC2), and organic anion transporting polypeptide 1B1 (OATP1B1, SLCO21A6 ). substrate assays were performed using Madin-Darby Canine Kidney (MDCK) cells expressing MDR1 and the efflux ratio [the ratio of the ratio of basolateral-to-apical (B-A) apparent permeability and A-B between MDR1 and MDCK) was 1.87, 2.32/4.46, 2.17/3.17, 0.93/2.00 for pravastatin, atorvastain (lactone/acid), lovastatin (lactone/acid), and simvastatin (lactone/acid), respectively, indicating that these compounds are weak or moderate substrates of P-glycoprotein. In the inhibition assays (MDR1, MRP2, Mrp2, and OATP1B1), the IC 50 values ( µ M) for efflux transporters (MDR1, MRP2 and Mrp2) were >100 for all statins in acid form except lovastatin acid (>33) and the IC 50 values were up to 10-fold lower for the corresponding lactone forms. In contrast, the IC 50 values ( µ M) for the uptake transporter OATP1B1 were 3- to 7-fold lower for statins in the acid form compared to the corresponding lactone form. These data demonstrate that lactone and acid forms of statins exhibit differential substrate and inhibitor activities towards efflux and uptake transporters. The intercoversion between the lactone and acid forms of most statins exists in the body and will potentially influence drug transporter interactions as a class and MRP2 and form of statins in The present study investigated the interaction of four model HMG-CoA reductase inhibitors (atorvastatin, lovastatin, and simvastatin in both acid and lactone forms and pravastatin in acid form only) with P-glycoprotein, MRP2, and OATP1B1 in vitro to understand the potential contributions of these transporters to the different pharmacokinetic properties of statins.
to Referee #3’s comments

Major comments: Comment 1: The authors deployed identical QC methods in this work and their earlier work (Rong et al. 2020; Xiuhui Zhang is the corresponding author for both studies). The authors calculated formation rates for pure IA nucleation in both studies, but a 1000 to 10,000 times difference can be found by comparing Fig. 3 of this study and Fig. 2 in Rong et al. 2020. A further check on Table S12 in Rong et al. 2020 and Table S2 in this study shows substantially different Gibbs free energy values for the same IA clusters at the same temperature. E.g., at 278 K, Rong et al. 2020 gives a ΔG of -5.92 kcal mol while this study gives -9.51 kcal mol. The difference seems small but as it goes in the exponential part of the evaporation rate equation, the resulted evaporation rates can be significantly different. My simplified calculation suggests that a -9.51 kcal mol-1 value easily results in a 500 times lower evaporation rate of iodic acid dimer compared to a value of -5.92. A further investigation on this matter comparing these two papers suggest at least two major differences. Rong et al. 2020 uses a double zeta basis set (aug-cc-pVDZ-PP) while this study uses a triple-zeta basis set (aug-cc-pVTZ-PP). However, I highly doubt that this is the primary reason for such a significant difference. I further tried to compare the geometries of the IA dimer in these two papers. As the authors provided wrong coordinates for IA dimer in SuppSection 6 in Rong et al. 2020, I have to infer from their Fig. S3 (cited here as Figure R1). The IA dimer is connected by two halogen bonds. However, in this study, the IA dimer is connected by two hydrogen bonds from my reproduced results based on coordinates in Table S7 of this manuscript. Additionally, the geometries of larger IA clusters in this study are also significantly different from Rong et al. 2020. The authors should visualize the IA clusters and any other clusters which are not yet visualized besides IA-MSA clusters in Fig S1.
Effects of musclin, exercise-induced myokine on glycosylated haemoglobin of hyperlipidemic rats with type 1 diabetes

Background and aims: Musclin is a factor secreted by skeletal muscle and a potent regulator of glucose metabolism that responds to exercise. Therefore, exercise-induced musclin may contribute to the pathogenesis of diabetes. The aim of the present study was to evaluate the effects of musclin, exercise-induced myokine on glycosylated hemoglobin (HbA1c) of hyperlipidemic rats with type 1 diabetes. Methods: Twenty-one male Wistar rats were divided into 3 groups of 7 rats per each: non-diabetic, diabetic and training diabetic. Type 1 diabetes was induced by injection of streptozotocin (55 mg/kg). After familiarization, training diabetic rats ran increasingly on a rodent treadmill for 4 weeks (5 consecutive days per week). After the 4-week period, serum glucose, insulin and musclin (using Elisa kit), and lipid profile (total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol) were measured and HbA1c was determined. Data were analyzed by two-way analysis of variance. Results: Increased serum musclin in hyperlipidemic diabetic rats increased HbA1c compared to non-diabetic rats ( p < 0.05). After 4 weeks of exercise training, HbA1c decreased along with a decrease in serum musclin in hyperlipidemic diabetic rats ( p < 0.05), so that a decrease in serum glucose and insulin in diabetic rats was associated with a improvement in lipid profile resulting in a decrease in HbA1c ( p < 0.05). Conclusion: Four weeks of aerobic training by regulating circulating musclin improved lipid profile and HbA1c in type 1 diabetes. Hence, musclin, exercise-induced myokine could decrease HbA1c in hyperlipidemic rats with type 1 diabetes.
CONCEPTUAL DEVELOPMENT OF THE LOGISTICS CHAIN FLOW OF CONTAINER TRANSPORT WITHIN THE RHINE-ALPINE CORRIDOR

The use of containers in the freight transport system has increased dramatically over the years. This is as a result of the interplay between macro-- and microeconomic factors and the liberalization of markets, thereby enhancing the development of international logistics services within transportation systems. The physical distribution of cargo in this system involves an integrated logistics chain process to transport the containerized goods from the production location to the consumption location. Different logistics chain models have been used to examine the flow of the containerized goods from origin to destination, however, these models mostly capture a specific module of the chain. To address this, the paper examines the whole logistics chain by linking the interaction between the logistics cost, time, mode choice and assignment to the network, while connecting with the different innovations that could make container IWT more competitive. In doing this, a conceptual logistics model is developed which includes the logistics cost, time, and mode choice sub-models. The two first sub-models are developed at a disaggregated level to examine the logistics decisions for the individual cargoes. The logistics decisions are derived from the minimization of transport-related costs and time and form the input of the mode choice and assignment sub-models.
Raising the bar (21)

ABSTRACT This editorial summarizes the papers published in issue 17(3) (2022). The first paper analyses the impact of knowledge spillovers on patent applications using a Tobit model. The second paper sets out an economic-theoretical model of industrial specialization patterns across cities and their impact on the spatial agglomeration of skilled workers and long-term productivity growth. The third paper analyses the price and average cost functions of a competitive industry in which firms face diseconomies of scale but enjoy economies of scale when they agglomerate. The fourth paper shows that productivity spillover effects and their endogeneity are key to understanding the productivity-compensation gap. The fifth paper studies geographical and sectoral specialization versus concentration of global supply chains. The sixth paper combines spatial autoregressive (SAR) and geographically weighted regression (GWR) models to test whether urban residents have reacted to the Covid-19 pandemic by moving out of US metropolitan centres into the suburbs. The seventh paper investigates the impact of natural disasters caused by climate change on forced outmigration flows in South and South-East Asian countries.
AC–DC bridgeless buck converter with high PFC performance by inherently reduced dead zones

In this study, a novel AC-DC bridgeless buck converter for power-factor-correction (PFC) applications with the inherent current-shaping ability and high PFC performance is proposed. Under a certain operation condition, dead zones in the proposed converter are reduced inherently compared with its conventional buck PFC counterpart, which result in higher PF and lower total harmonic distortion significantly. Furthermore, two rectifier diodes are eliminated, which contributes to efficiency. The detailed operation principle and theoretical analysis of discontinuous conduction mode (DCM) are presented. The simulation comparison between the conventional and proposed bridgeless buck PFC converter is also described. Finally, an experimental lab-made prototype operating in DCM is constructed to validate the feasibility of this proposed converter.
Use of stroke scales in clinical practice: Current concepts

With stroke being the leading global cause of disability in adults, the use of clinical rating scales in stroke patients is important not only for diagnostic and therapeutic purposes but also for prognostic and care implications. Scales that quantify neurological disability can be particularly useful for assessing and guiding decisions in acute management and rehabilitative treatment. We analyzed and discussed some of the main rating scales most used in stroke in clinical practice, which measure both acute neurological deficit and functional outcome in stroke. In acute stroke, it is that in most cases, the scales evaluate a neurological deficit attributable to an alteration of the anterior and not posterior circulation and most of them assess a moderate stroke rather than a mild or severe one. In a rehabilitation treatment, they are sometimes too simplified; thus, the patient can reach a near-normal score and can have significant cognitive deficits that can affect both the possibility of communication and the reliability of responses. A patient with autonomy in the activities of daily living may not be completely autonomous. In future, the use of composite rating scales could be useful for a detailed measurement of neurological deficits in acute stroke and better assess the efficacy of a treatment and functional outcome.
Re: Sivaraman A, Ramasamy V, Aarthy P, Sankar V, Sivaraman PB. Safety and feasibility of freehand transperineal prostate biopsy under local anesthesia: Our initial experience. Indian J Urol 2022;38:34-41

We read with great interest the newly published study on freehand transperineal prostate biopsy, published in the journal. [1] I congratulate the researchers for making an important contribution to the literature and clinical practice on cognitive fusion biopsy. In the present study, the authors shared the results of freehand transperineal cognitive fusion biopsy using the PrecisionPoint device (PrecisionPointTM BXTAccelyon) in 50 patients and reported that this technique has satisfactory cancer (overall; 82% and clinical significant prostate cancer [CSPC]; 78%) rates and acceptable complications.
Digitally Controlled Oscillator for mm-Wave Frequencies

In the fifth generation of mobile communication, 5G, frequencies above 30 GHz, so-called millimeter-wave (mm-wave) frequencies are expected to play a prominent role. For the synthesis of these frequencies, the all-digital phase locked loop (ADPLL) has recently gained much attention. A core component of the ADPLL is the digitally controlled oscillator (DCO), an oscillator that tunes the frequency discretely. For good performance, the frequency steps must be made very small, while the total tuning range must be large. This thesis covers several coarse- and fine-tuning techniques for DCOs operating at mm-wave frequencies. Three previously not published fine-tuning schemes are presented: The first one tunes the second harmonic, which will, due to the Groszkowski effect, tune the fundamental tone. The second one is a current-modulation scheme, which utilizes the weak current-dependence of the capacitance of a transistor to tune the frequency. In the third one, a digital-to-analog converter (DAC) is connected to the bulk of the differential pair and tunes the frequency by setting the bulk voltage. The advantages and disadvantages of the presented tuning schemes are discussed and compared with previously reported fine-tuning schemes. Two oscillators were implemented at 86 GHz. Both oscillator use the same oscillator core and hence have the same power consumption and tuning range, 14.1 mW and 13.9%. A phase noise of -89.7 dBc/Hz and -111.4 dBc/Hz at 1 MHz and 10 MHz offset, respectively, were achieved, corresponding to a Figure-of-Merit of -178.5 dBc/Hz. The first oscillator is fine-tuned using a combination of a transformer-based fine-tuning and the current modulation scheme presented here. The achieved frequency resolution is 55 kHz, but can easily be made finer. The second oscillator utilizes the bulk bias technique to achieve its fine tuning. The fine-tuning resolution is here dependent on the resolution of the DAC; a 100μV resolution corresponds to a resolution of 50 kHz. (Less)