Miracle-dz/UniFAR-FTUs huggingface dataset:
Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema

Hamamelis virginiana L. bark extract is a traditional remedy for skin affections, including atopic dermatitis/eczema (AD). Hamamelis preparations contain tannins, including hamamelitannin (HT), although their pharmacological role in AD is still unknown. This study aimed to study the rational for its topical use by considering the impact of crucial biomarkers on AD pathogenesis. A standardized extract (HVE) (0.5–125 μg/mL) was compared to hamamelitannin (HT), its main compound (0.5–5 μg/mL), in a model of human keratinocytes (HaCaTs), challenged with an AD-like cytokine milieu (TNF-α, IFN-γ, and IL-4). HVE inhibited the release of mediators involved in skin autoimmunity (IL-6 and IL-17C) and allergy (TSLP, IL-6, CCL26, and MMP-9) with a concentration-dependent fashion (IC50s < 25 μg/mL). The biological mechanism was ascribed, at least in part, to the impairment of the NF-κB-driven transcription. Moreover, HVE counteracted the proliferative effects of IL-4 and recovered K10, a marker of skin differentiation. Notably, HT showed activity on well-known targets of IL-4 pathway (CCL26, K10, cell proliferation). To the best of our knowledge, this work represents the first demonstration of the potential role of Hamamelis virginiana in the control of AD symptoms, such as itch and skin barrier impairment, supporting the relevance of the whole phytocomplex.
Excitation of Two Types of Storm‐Time Pc5 ULF Waves by Ring Current Ions Based on the Magnetosphere‐Ionosphere Coupled Model

Two types of storm‐time Pc5 waves are excited in the magnetosphere–ionosphere coupled model. We conduct magnetosphere–ionosphere (M–I) coupling between geospace environment modeling system for integrated studies‐ring current (GEMSIS‐RC) and GEMSIS‐POTential solver (GEMSIS‐POT) models in order to investigate the excitation of storm‐time Pc5 waves under more realistic conditions. The coupled model enables us to simulate ion transport from the plasma sheet by the convection electric field. First, we find the excitation of fundamental mode Pc5 waves on the dayside. These waves are generated by the drift resonance and driven by positive energy gradient of ion phase space density (PSD). The wave excitation is similar with the case without M–I coupling. Second, we detect second harmonic mode Pc5 waves with high azimuthal wave number in the dusk and premidnight region. The PSD oscillates associated with the waves, and the drift‐bounce resonance occurs at 50–80 keV ions. We find that these ions drift around the Earth and reach the nightside again at t ∼ 4,500 s, whose time scale is comparable to the drift period of these ions. At that time, inward gradient of the PSD is created, which contributes to the wave growth. This effect does not happen in the case without dawn‐to‐dusk convection electric field driven by Region 1 field aligned current (FAC). We find that the shielding by Region 2 FAC suppresses the flux of newly injected ions at the nightside, inward gradient of the PSD, and power spectra of second harmonic mode waves.
HAMNet: hyperspectral image classification based on hybrid neural network with attention mechanism and multi-scale feature fusion

ABSTRACT Recently, convolutional neural network (CNN) has made great progress in hyperspectral image (HSI) classification. Considering the problems of high dimensions, limited training samples and intra-class variations of hyperspectral data, there are challenges for traditional pure 2D or 3D deep convolutional neural networks in classifying HSI. Deeper layers bring gradient dispersion, while 3D feature blocks bring a large number of parameters during feature fusion. In this paper, an end-to-end hybrid convolutional neural network is proposed for HSI classification. Firstly, 3D, 2D and 1D convolution modules are applied, respectively, to perform joint feature extraction of spatial and spectral information. Secondly, a new 3D multi-scale feature fusion strategy is proposed to fuse the high-level and low-level features for ensuring the feature sufficiency. Moreover, channel attention mechanism is introduced to avoid feature channel redundancy and strengthen effective features. Comparative experimental results show that the method can receive satisfactory results on public data sets and small-sample learning problem.
Defective Complements in Tree Adjoining Grammar

Syntactic theory has long made use of the idea that clausal complements can be different sizes. For example, while the finite complement to believes in (la) projects up to CP, the nonfinite complement in (lb) projects only to IP. The most obvious reason for this approach is, of course, that the finite complement can have a complementizer, while the nonfinite one cannot. This is, in turn, related to accounts of how Case can be assigned to the complement subject when the complement is IP but not CP. 1 Another example of how smaller complements are used in syntactic theory is of course the case of subject-tosubject raising, as in (2a). Such raising is only possible when the complement is a an IP, but not a CP (2b ). Restrictions on movement are therefore correlated with the size of the complement.
Cross-regional effects of renewable power generation on the electricity market: an empirical study on Japan's electricity spot market

ABSTRACT We examined the indirect effects of renewable power generated in Tohoku on the electricity spot market in Tokyo, through the channel of cross-regional interconnection. By adopting a two-step regression analysis framework, we investigated how the renewable power generated in Tohoku affects Tokyo’s spot price and market volatility. Our results indicate that the electricity spot market is affected not only by within-regional renewable power generation but also by cross-regional transmitted renewable power generation through interconnection. The relatively higher price reduction effect of transmitted power can be attributed to higher price elasticity under a tight supply-demand balance. Our results confirm the cross-regional price stabilization effect of renewable power generation in Tohoku. We attribute the negative effect on realized volatility of Tokyo to the relatively stabler renewable electricity supply from Tohoku. Furthermore, we find that renewable power producers – especially solar power producers – are not incentivized by the fixed-price feed-in tariff to meet electricity demand during peak hours.
Faktor Determinasi Minat Penggunaan Layanan Linkaja Syariah Pada Masyarakat Jabodetabek

Linkaja resmi merilis layanan LinkAja Syariah. Hadirnya sistem pembayaran digital berbasis syariah ini diharapkan dapat memberikan andil dalam perkembangan ekonomi dan keuangan syariah. Penelitian ini bertujuan untuk menjelaskan pengaruh dari faktor-faktor determinasi minat penggunaan layanan Linkaja Syariah di Jabodetabek, yaitu Kemudahan Penggunaan, Manfaat, Risiko, dan Inovasi Teknologi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode regresi linier berganda. Populasi dari penelitian ini ialah masyarakat Jabodetabek yang pernah menggunakan layanan Linkaja Syariah atau setidaknya mengetahui layanan tersebut. Hasil yang diperoleh dari penelitian ini menjelaskan bahwa Inovasi teknologi tidak berpengaruh secara signifikan terhadap minat penggunaan layanan Linkaja Syariah. Sementara itu, Kemudahan Penggunaan, Manfaat, dan Risiko mempunyai pengaruh yang positif dan signifikan terhadap minat penggunaan layanan Linkaja Syariah. Untuk pihak Linkaja dapat mempertimbangkan faktor-faktor tersebut, agar dapat menarik minat masyarakat untuk menggunakan layanan Linkaja Syariah. Selain itu, variabel Manfaat dan Kemudahan Penggunaan mempunyai pengaruh paling besar terhadap minat penggunaan layanan Linkaja syariah dibanding variabel lainnya. Oleh karena itu, Pihak Linkaja hendaknya lebih gencar melakukan sosialisasi dan promosi terkait kemudahan dan manfaat pada sistem pembayaran dan fitur-fitur di Linkaja Syariah. Untuk Pemerintah kedepannya juga dapat memberikan program-program edukasi terkait dengan uang elektronik syariah, sehingga akhirnya masyarakat akan teredukasi dan sadar akan adanya kemudahan dan manfaat dari layanan syariah berbasis teknologi. Hal ini juga demi tercapainya tujuan pemerintah untuk menciptakan ekosistem halal di Indonesia.
Comparative Study between the Effect of Ginger and Cinnamon Aqueous Extracts and their Mixtures on Hyperlipidemic Rats

This study was performed to comparing the effect of different levels of ginger and cinnamon extracts and their mixture on Hyperlipidemic rats. Sixty six adult albino rats were divided into eleven groups (6 rats each group). Group1: Negative control group fed on standard diet, group 2: Positive control group fed on high fat diet (HFD). Group: 3, 4 and 5 the rats fed on high fat diet (HFD) containing 200mg, 300mg and 400mg/100g diet ginger water extracts concentrated (Con). Group: 6, 7 and 8 the rats fed on HFD containing 200, 300 and 400mg cinnamon water extracts Con. Group: 9, 10 and 11 the rats fed on HFD containing mixture (100mg ginger+100mg cinnamon extracts Con.), (150 mg ginger + 150mg cinnamon extracts Con.) and (200mg ginger+200mg cinnamon water extracts Con.) for 8 weeks. The aqueous extract of ginger and cinnamon are containing 1.21 mg/g and 1.15 mg /g total phenolic compounds. Meanwhile total flavonoids were 0.38 mg/g and 0.41 mg/g of ginger and cinnamon water extracts. Cinnamon extract contained high level sinapic acid (59.22±03 μg/g) meanwhile ginger extract have high concentration of zingerone (33.28±0.01 μg/g). The results showed that all treatment after 8 weeks caused a significantly decrease of triglycerides (TG), total cholesterol (TC), low 13.5±1.5 mg/dl and 0.36± 0.04) respectively more than ginger water extract (78.83±10.7, 154.17±20.1, 123.5±15.5, 15,8±2.1mg/dl and 0.44±0.05) respectively. Urea and in creatinin hyperlipidemic rat was a significant increased P≤0.05 in contract to antioxidant enzymes were revealed a significantly decrease compared to negative control group. High concentration of cinnamon extract (400 mg) showed the highest decrease in urea (30.83±6.05 mg/dl) and aspartate amino transferase AST (22.33±1.63 IU/L) and the highest increase in superoxide dismutase (SOD) activity (0.23±0.01 IU/L). Conclusion: Using cinnamon and ginger extracts for 8 weeks have beneficial effects to reduced serum lipid profile in hyperlipidemic rats. The high concentration of cinnamon extract had hypolipidemic effect more than ginger extract because its content high levels of cinnamic acid and cinapic acid which have antioxidant effects. The present study recommended that the admenstration of cinnamon water extract when consuming high fat diet. ______________________________________________________
Consequence of Foliar Application Treatments with Npk on Productivity of Bread Wheat

A field experiment was conducted during 2020/2021 winter season in a special field South of Baghdad in the district of Kothi (Jableh) Al-Hamiri region, North of Babil Governorate, to study consequence of some foliar appliance treatments by way of nitrogen, phosphorus in addition to potassium (NPK) on productivity of bread wheat Ibaa-99 cultivar. The experiment was conducted in a Randomized Complete Block Design (RCBD) in three replications. The considered foliar application treatments were as follows; without spraying, spraying with nitrogen at 4000 mg L -1 , phosphorous at 2000 mg L -1 , potassium at 4000 mg L -1 and the mixture of nitrogen, phosphorous and potassium. Spraying wheat plants with the mixture of nitrogen (4000 mg L -1 ), phosphorous (2000 mg L -1 ) and potassium (4000 mg L -1 ) fertilizers significantly increased growth, yield and its components as compared with other studied foliar application treatments. The second-best foliar application treatment was spraying wheat plants with nitrogen at 4000 mg L -1 , go after by spraying plants with K at 4000 mg L -1 , then spraying plants with P at 2000 mg L -1 and lastly control treatment (without foliar application). It may well be decided that spraying wheat plants with the mixture of nitrogen at 4000 mg L -1 , phosphorous at 2000 mg L -1 and potassium at 4000 mg L -1 to improve growth, yield and its components of bread wheat Ibaa-99 cultivar under the environmental conditions of studying area stage under the environmental conditions of studying area.
What We Need to Know about Liposomes as Drug Nanocarriers: An Updated Review

Liposomes have been attracted considerable attention as phospholipid spherical vesicles, over the past 40 years. These lipid vesicles are valued in biomedical application due to their ability to carry both hydrophobic and hydrophilic agents, high biocompatibility and biodegradability. Various methods have been used for the synthesis of liposomes, so far and numerous modifications have been performed to introduce liposomes with different characteristics like surface charge, size, number of their layers, and length of circulation in biological fluids. This article provides an overview of the significant advances in synthesis of liposomes via active or passive drug loading methods, as well as describes some strategies developed to fabricate their targeted formulations to overcome limitations of the "first-generation" liposomes.
Effect of Applying Designed Nursing Guidelines on Health Outcomes among Patients with Heart Failure Class III

: Background: Heart failure continues to increase in prevalence with a great impact on morbidity and mortality. Aim: To evaluate the effect of applying designed nursing guidelines on health outcomes among patients with heart failure class III. Research design: Quasi-experimental (pre & post assessment) design. Setting: The study was carried out in the Inpatient Cardiology Department at Al-Azher University Hospitals & affiliated Outpatient Cardiac Clinic. Sample: A purposeful sample of (30) patients their ages ranged from (20–75) years old from both sexes. Tools: tool (1): Patient Structured interview questionnaire. Tool (II): Dutch Heart Failure Knowledge Scale. Tool (III): Structured Outcomes Assessment of Patient with Heart Failure. Results: there was statistical significant difference as regarded total knowledge score level, diet categories & red, yellow zone exacerbation signs and symptoms of the study sample in relation to all items in pre & post nursing guidelines with P. value < 0.001 Conclusion: significant improvement in health outcomes among patients with heart failure class III post nursing guidelines application in form of dietary modifications, knowledge improvement, reduce worsen exacerbating signs & symptoms. Recommendation : Study risk factors associated with preventable heart failure exacerbations at regular intervals after hospital discharge
Measurements of railgun generatedsupersonic plasma jet propagation andtwo jet oblique merging

Imploding spherical plasma liners have been proposed as a possible method for creating high-energy-density (HED) laboratory plasmas and as a standoff driver for magneto-inertial fusion (MIF). The Plasma Liner Experiment (PLX) planned a three-phase experimental program to study the feasibility of using railgun-driven supersonic jets to form imploding spherical plasma liners. The three phases are to investigate single-jet evolution during propagation, to merge 2–5 jets to assess the suitability of merging for liner formation, and to merge 30 jets in spherical symmetry to form a complete liner. We present here details of single-jet propagation and two-jet oblique merging experiments completed on PLX. A key component of this dissertation was the design, implementation, and operation of a novel 8 chord, fiber-coupled interferometer based on a long coherence length (> 100 m) 561 nm diode-pumped solid state laser. This interferometer was a critical diagnostic in both single-jet propagation and two-jet merging studies. The long laser coherence length and fiber-optic design allowed signal and reference path lengths in
Knockdown of the Halloween Genes spook, shadow and shade Influences Oocyte Development, Egg Shape, Oviposition and Hatching in the Desert Locust

Ecdysteroids are widely investigated for their role during the molting cascade in insects; however, they are also involved in the development of the female reproductive system. Ecdysteroids are synthesized from cholesterol, which is further converted via a series of enzymatic steps into the main molting hormone, 20-hydoxyecdysone. Most of these biosynthetic conversion steps involve the activity of cytochrome P450 (CYP) hydroxylases, which are encoded by the Halloween genes. Three of these genes, spook (spo), phantom (phm) and shade (shd), were previously characterized in the desert locust, Schistocerca gregaria. Based on recent sequencing data, we have now identified the sequences of disembodied (dib) and shadow (sad), for which we also analyzed spatiotemporal expression profiles using qRT-PCR. Furthermore, we investigated the possible role(s) of five different Halloween genes in the oogenesis process by means of RNA interference mediated knockdown experiments. Our results showed that depleting the expression of SchgrSpo, SchgrSad and SchgrShd had a significant impact on oocyte development, oviposition and hatching of the eggs. Moreover, the shape of the growing oocytes, as well as the deposited eggs, was very drastically altered by the experimental treatments. Consequently, it can be proposed that these three enzymes play an important role in oogenesis.
High-Isolation 3.5 GHz Eight-Antenna MIMO Array Using Balanced Open-Slot Antenna Element for 5G Smartphones

A high-isolation eight-antenna multi-input multi-output (MIMO) array operating in the 3.5 GHz band (3.4–3.6 GHz) for future smartphones is proposed. Here, a novel balanced open-slot antenna is designed as an array antenna element, in which this antenna design can yield a balanced slot mode (with reduced ground effects) that can enhance the isolation between two adjacent input ports. Furthermore, by meticulously arranging the positions of the eight antenna elements, desirable polarization diversity can also be successfully achieved, which further mitigates the coupling between antenna elements. A prototype was manufactured to validate the simulation. A good impedance matching (return loss > 10 dB), high isolation (>17.5 dB), high total efficiency (>62%), and low envelope correlation coefficient (ECC, <0.05) were measured across the desired operation bandwidth. To verify the MIMO performance, ergodic channel capacity using the Kronecker channel model was calculated. The effects of hand phantom were also studied.
Late Holocene Morphodynamic Feedback in Can Gio Mangrove Tide-Dominated River Mouth Systems, Vietnam

Can Gio (CG), a mangrove forest with a dense network of tidal creeks, gradually grew and spread seaward on a coastal platform, which was built since about 8 ka before present (BP). Along with this development, a sand ridge began to form and moved back with the shoreline withdrawal landward in the Late Holocene. This mangrove environment is likely abandoned from the mainland but was, however, the place for settlement of ancient Vietnamese a few centuries BC. The CG mangrove forest was severely destroyed during the American War and was restored since 1980. However, the historical change of the landscape along the Saigon-Dong Nai River (SG-DNR) since the Late Holocene is not completely unraveled. By analyzing sediment cores with a multiproxy approach, we investigated the recent geological development with regard to the variation of the intensity of the East Asian palaeomonsoon and regarding the accommodation space, as both regulate the development of this coastal environment. A recently significant shift in the coastline, mainly due to a change of hydroclimatic factors, was observed. A continuous coastline retreat occurred over the last millennium, changing the depositional environment and reshaping the CG mangrove landscape. Along the present coast and tidal channels, partially strong erosion and bank failures occur, alternating with accretion at other coastal sections. This development tends to increase progressively.
How to do it? Transcatheter correction of superior sinus venosus defects

Superior sinus venosus defect is characterized by varying degrees of override of the atrial septum by the superior vena cava and anomalous right upper pulmonary vein (RUPV) drainage. The defect is seen posterosuperior to the oval fossa and is traditionally corrected by a surgical patch that routes the anomalously draining RUPV to the left atrium. A few postoperative patients develop stenosis or occlusion of the caval or pulmonary vein and/or sick sinus syndrome secondary to vascular injury. This has kindled a recent interest in nonsurgical correction of these defects by the use of a covered stent to reroof the defect. The complex anatomy of this defect often necessitates the use of advanced imaging tools and postprocessing. Countries with restricted resources do not have easy access to technologies such as three-dimensional printed models and advanced processing like virtual reality or holography. This “How to do it? ” article, applicable in these countries, explains the current understanding of this intervention, patient selection, step-by-step explanation of the evaluation, and stent implantation.
A Novel Artificial Visual System for Motion Direction Detection in Grayscale Images

How specific features of the environment are represented in the mammalian brain is an important unexplained mystery in neuroscience. Visual information is considered to be captured most preferentially by the brain. As one of the visual information elements, motion direction in the receptive field is thought to be collected already at the retinal direction-selective ganglion cell (DSGC) layer. However, knowledge of direction-selective (DS) mechanisms in the retina has remained only at a cellular level, and there is a lack of complete direction-sensitivity understanding in the visual system. Previous studies of DS models have been limited to the stage of one-dimensional black-and-white (binary) images or still lack biological rationality. In this paper, we innovatively propose a two-dimensional, eight-directional motion direction detection mechanism for grayscale images called the artificial visual system (AVS). The structure and neuronal functions of this mechanism are highly faithful to neuroscientific perceptions of the mammalian retinal DS pathway, and thus highly biologically reasonable. In particular, by introducing the horizontal contact pathway provided by horizontal cells (HCs) in the retinal inner nuclear layer and forming a functional collaboration with bipolar cells (BCs), the limitation that previous DS models can only recognize object motion directions in binary images is overcome; the proposed model can solve the recognizing problem of object motion directions in grayscale images. Through computer simulation experiments, we verified that AVS is effective and has high detection accuracy, and it is not affected by the shape, size, and location of objects in the receptive field. Its excellent noise immunity was also verified by adding multiple types of noise to the experimental data set. Compared to a classical convolutional neural network (CNN), it was verified that AVS is completely significantly better in terms of effectiveness and noise immunity, and has various advantages such as high interpretability, no need for learning, and easy hardware implementation. In addition, activation characteristics of neurons in AVS are highly consistent with those real in the retinal DS pathway, with strong neurofunctional similarity and brain-like superiority. Moreover, AVS will also provide a novel perspective and approach to understanding and analyzing mechanisms as well as principles of mammalian retinal direction-sensitivity in face of a cognitive bottleneck on the DS pathway that has persisted for nearly 60 years.