Miracle-dz/UniFAR-FTUs huggingface dataset:
Limitations of Existing Dialysis Diet Apps in Promoting User Engagement and Patient Self-Management: Quantitative Content Analysis Study

Background With the unprecedented growth of mobile technology, a plethora of dialysis diet apps have been developed to promote patient dietary self-management. Nevertheless, the utility of such apps remains questionable. Objective This study aimed to evaluate the content, features, and quality of commercial dialysis diet apps for adult dialysis patients. Methods This study consisted of a quantitative content analysis of commercial dialysis diet apps downloaded from Google Play and the Apple App Store available in the Asian marketplace, searched for using the following keywords in English: dialysis diet and diet for kidney disease. Free and paid apps available in English that provide nutrition information for adult dialysis patients were included. Apps that were not relevant to the dialysis diet, not meant for patient self-management, or redundant were excluded. Apps were evaluated for language medium (subscore=1), credibility (subscore=1), food database (subscore=1), valuable features (subscore=12), health-behavior theory constructs (subscore=60), and technical quality (subscore=25). The relationships among the variables of interest were determined by Pearson correlation. Stepwise multiple linear regression analysis was performed to identify the features that contribute to greater technical quality of dialysis diet apps. Statistical significance was defined as P<. 05. Results A total of 22 out of 253 apps (8.7%) were eligible for evaluation. Based on a 100-point scale, the mean overall score of the apps was 31.30 (SD 14.28). Only 5% (1/22) of the apps offered relevant language options, and 46% (10/22) contained food databases. In addition, 54% (12/22) of the apps were not credible. The mean score for valuable features was 3.45 (SD 1.63) out of 12, in which general education (16/22, 73%), free download (15/22, 68%), and usability (13/22, 59%) were the three most popular features. However, the apps scored a mean of 13.41 (SD 11.56) out of 60 for health-behavior theory constructs. The overall app technical quality was considered poor, with a mean score of 2.70 (SD 0.41) out of 5. The scores of valuable features (r=.65, P=.001) and health-behavior theory constructs (r=.55, P=.009) were positively correlated with the overall technical quality of the commercial dialysis diet apps. Features such as free download (β=.43, P=.03) and usability (β=.41, P=.03) could significantly determine the functional quality of the apps. Health-behavior theory constructs such as self-monitoring could significantly predict both the subjective quality (β=.55, P=.008) and the engagement quality (β=.66, P=.001) of the apps, whereas the information quality domain could be determined by plan or orders (β=.48, P=.007) and knowledge (β=.45, P=.01). Conclusions Although most of the available commercial dialysis diet apps are free and easy to use, they are subject to theory deficiency, limited language options, and a lack of food databases, credibility, tailored education, and overall technical quality.
Genetic variability for yield and its components in Indian mustard (Brassica juncea L. Czern & Coss).

Study of 60 genotypes of Indian mustard (Brassica juncea L. Czern & Coss) for 13 different characters revealed considerable variability for all the characters under study. The eight characters viz., days to 50% flowering, days to maturity, number of secondary branches per plant, length of main branch, number of siliqua per plant, number of seeds per siliqua, test weight and seed yield per plant showed high estimates of GCV as well as high heritability. The characters like number of secondary branches per plant, seed yield per plant and number of siliqua per plant, in that order, exhibited high heritability and high expected genetic advance. Hence selection will be effective for these traits.
Exploring potential drug target sites in the ribosome using cisplatin and its analogues

EXPLORING POTENTIAL DRUG TARGET SITES IN THE RIBOSOME USING CISPLATIN AND ITS ANALOGUES by KESHAB RIJAL May 2011 Advisor : Prof. Christine S. Chow Major : Chemistry Degree : Doctor of Philosophy Cis-diamminodichloridoplatinum (II), cisplatin, is an antitumor drug that has been used to treat several types of cancers. The reaction of cisplatin with DNA has been studied and discussed extensively in the literature; however, the effects of cisplatin on RNA function are poorly understood. In this thesis, two aspects of cisplatin, its preferred sites of interaction with RNA and its use as a chemical probe to gain accessibility information, were explored. To understand the site-selectivity of cisplatin with RNA, model RNA constructs and full-length 16S rRNA were employed. The binding studies revealed a cisplatin preference for guanosine-rich sequences. Primer extensions in 16S rRNA and MALDI-TOF in model constructs were used to locate the binding sites of cisplatin. HPLC and LC-MS were useful to determine the types and ratios of various adducts formed. Cisplatin and its analogues were employed to probe the accessibility of nucleotides on 16S rRNA, 30S subunits and 70S ribosomes in vitro as well as in vivo. This study revealed that many functionally
Incisor arcades of Alaskan moose: is dimorphism related to sexual segregation?

We tested whether incisor arcades of Alaskan moose (Alces a/ces gigas) differed between males and females ofknown age to examine how allometric differences in jaw architecture might relate to sexual segregation. Lower jaws were collected from moose killed by hunters, and from moose that died of either natural causes or collisions with vehicles. We measured the breadth (width) and the depth (protrusion) of the incisor arcade of moose; age was determined by counting cementum annuli of incisors. Arcade breadth of moose followed von Bertalanffy models of growth, with an asymptote at about 4 years of age for both sexes. Regression models differed for male and female moose; arcade breadth for males was significantly larger than for females. Data from the literature indicated body mass of females also reaches an asymptote at 4 years old. Males, however, do not attain an asymptote in body mass until 8-10 years of age. When incisor breadth was considered relative to asymptotic body mass, incisor breadth of males was less than that offemales. Coefficients of incisor breadth relative to body mass, however, scaled similarly for male (0.249) and female (0.260) moose. Incisor depth did not differ between the sexes when depth was corrected for age. Our data indicate that incisor breadth, but not depth, scaled with body mass. Thus, muzzle morphology may exhibitmore plasticity than previously thought. We hypothesize that muzzle architecture of moose, as reflected in incisor breadth and depth, relates to the diets of the sexes when they are spatially segregated. Whether incisor dimensions are a cause or consequence of sexual segregation, however, is uncertain. ALCES VOL. 37 (1): 217-226 (2001)
Yoiyo y la sexualidad: una misión en Ultreia

La implementacion de la educacion sexual en Espana representa una “asignatura pendiente” de nuestro sistema educativo a pesar de disponer de programas integrales disenados y adaptados a la educacion formal. Se presenta en este capitulo el programa de educacion sexual “Yoiyo y la Sexualidad. Mision en Ultreia”, un programa multimedia disenado para promocionar la salud sexual y reproductiva a lo largo del ciclo vital. Partimos de la conceptualizacion de Salud Sexual recogida en laLey Organica 2/2010, de “Salud Sexual y Reproductiva y de la Interrupcion Voluntaria del Embarazo”, lo que implica que la salud ha de transversalizar toda nuestra dimension sexuada, desde la identidad a la conducta. Este programa se fundamenta en el derecho y el deber de la educacion sexual a traves de un modelo integral anclado en los derechos, la igualdad y la diversidad. Los modelos integrales (Comprehensive Sexual Education), como el que aqui se presenta, cuentan con los mayores avales no solo para reducir los riesgos vinculados a la actividad sexual sino especialmente para la promocion deun verdadero bienestar que contemple el desarrollo egosintonico de la dimension identitaria, que se plasme en unas relaciones igualitarias, solidarias, respetuosas con la diversidad y libres de violencia.
Diagnostic protein biomarkers for severe, moderate and mild traumatic brain injury

Traumatic Brain Injury (TBI) is a major problem in military and civilian medicine. Yet, there are no simple non-invasive diagnostics for TBI. Our goal is to develop and clinically validate blood-based biomarker assays for the diagnosis, prognosis and management of mild, moderate and severe TBI patients. These assays will ultimately be suitable for deployment to far-forward combat environments. Using a proteomic and systems biology approach, we identified over 20 candidate biomarkers for TBI and developed robust ELISAs for at least 6 candidate biomarkers, including Ubiquitin C-terminal hydrolase- L1 (UCH-L1), Glial Fibrillary Acidic Protein (GFAP) and a 145 kDa breakdown products of αII-spectrin (SBDP 145) generated by calpain proteolysis. In a multi-center feasibility study (Biomarker Assessment For Neurotrauma Diagnosis And Improved Triage System (BANDITS), we analyzed CSF and blood samples from 101 adult patients with severe TBI [Glasgow Coma Scale (GCS) ≤ 8] at 6 sites and analyzed 27 mild TBI patients and 5 moderate TBI patients [GCS 9-15] from 2 sites in a pilot study. We identified that serum levels of UCH-L1, GFAP and SBDP145 have strong diagnostic and prognostic properties for severe TBI over controls. Similarly initial post-TBI serum levels (< 6 h) of UCH-L1 and GFAP have diagnostic characteristics for moderate and mild TBI. We are now furthering assay production, refining assay platforms (both benchtop and point-ofcare/ handheld) and planning a pivotal clinical study to seek FDA approval of these TBI diagnostic assays.
The Role of Nuclear BMP2 in the Cell Cycle and Tumorigenesis

The Role of Nuclear BMP2 in the Cell Cycle and Tumorigenesis Brandt Alan Nichols Department of Microbiology and Molecular Biology Master of Science Bone morphogenetic protein 2 (BMP2) is a secreted growth factor that is essential for proper embryonic development and proliferation. Our laboratory discovered a nuclear variant of BMP2 (nBMP2) which is produced when translation is initiated at an alternative start codon within the BMP2 gene. When translation occurs at the downstream start codon, the resulting protein lacks the ER signal peptide, thereby allowing cytoplasmic translation and nuclear localization. Our aim is to distinguish the role of this nuclear localized variant from secreted BMP2. Overexpression of nBMP2 in HEK293 and HT29 cell lines resulted in a higher percentage of cells in proliferative phases of the cell cycle. We determined that nBMP2 does not regulate cell cycle progression by inducing hyperphosphorylation of retinoblastoma protein (Rb), but it may regulate the cell cycle by interacting with ROC1. In order to examine the role of nBMP2 in vivo, we have generated a mouse model in which a mutation of the nuclear localization signal (NLS) disrupts nuclear localization of nBMP2. Aberrant crypts were more abundant in nBmp2NLS azoxymethane (AOM) treated mice than in wild type mice. Furthermore, H&E staining of colonic tissue showed that mutant mice have increased levels of dysplasia and aberrant crypt foci. This work suggests that nBMP2 is involved in regulating cell cycle progression and proliferation, and therefore may play a role in tumorigenesis.
Effect of High Frequency Transcranial Magnetic Stimulation on Upper Extremity Motoric Function in Subacute Stroke Ischemic Patient at Dr. Soetomo General Hospital Surabaya

: Stroke cause motoric function disturbances that can decrease quality of life. Damaged brain caused by stroke have an ability to repair itself which is called neuroplasticity. Transcranial Magnetic Stimulation (TMS) was introduced as a non-invasive tool that could stimulate damaged brain hemisphere to increase neuroplasticity. This study aimed to prove and determine the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on upper extremity motoric function in subacute stroke ischemic patient. Eighteen subjects included in inclusion criteria, divided into 2 groups, control and intervention group. Control group had conventional therapy for 5 days consecutively and intervention group had conventional therapy and rTMS for 5 days consecutively. Upper extremity motoric function was evaluated with Fugl-Meyer Assessment (FMA). It was done before and after the intervention had completed. There were increasing of FMA score in control group 53.2 to 57.4 (p=0,012) and intervention group 40.3 to 54.1 (p=0,000). The increasing of FMA score in intervention group was higher 13.7 vs 4.2 (p=0,000). Combination of conventional and TMS therapy improved upper extremity function better than single conventional therapy in subacute stroke ischemic patient.
Role of EDDS and ZnO-nanoparticles in wheat exposed to TiO2Ag-nanoparticles

of critical metals from a soil-plant system or to hinder the metal precipitation. Thus they can enhance the essential metallic nutrients’ uptake by plants (Pinto et al. 2014) and are preferred to substitute the non-biodegradable chelating agents. Among these agents, EDDS has a relatively low molecular weight, is biodegradable and non-toxic to living organisms.Soil type, pH value, and soil organic matter content are the most in ﬂ uencing parameters to determine the effects of contaminants on plants. Metal extraction with plants may be increased by synthetic chelating agents (Bech et al. 2014, Sidhu et al. 2017) because of their strong complexes with metal ions (Pinto et al. 2014). Sidhu et al. (2017) investigated the effects of ammonium molybdate and EDDS on Pb mobilization and extraction by Coronopus didymus . Researchers used contaminated soil at a concentration of 1200 and 2200 mg ∙ kg -1 Pb. Moreover, 2 mmol ∙ kg -1 ammonium molybdate and EDDS were used to determine the effects on Pb uptake and accumulation by C. didymus . Also, the authors determined if these chelators alleviate the uptake of lead from contaminated soil, or not. Results showed that the chelators enhanced the uptake and accumulation of Pb. Abstract: Nanotechnology is a manipulation of nature that has emerged through the use of basic sciences, material science and engineering at the nano-scale. The interaction between biological environment and nanoparticles--nanoparticles or nanoparticles-organic materials is not yet well-understood. The toxic effects of nanoparticles on plants were investigated and it was proved that they caused morphological and physiological changes in plants. This study aimed to determine the effects of TiO 2 Ag nanoparticles alone, co-application of ZnO nanoparticles--TiO 2 Ag nanoparticles, and co-application of EDDS-TiO 2 Ag nanoparticles on seed germination, seedling vigor, radicle and plumule elongation of two different wheat species. In the experimental stage, ten seeds were placed in petri-dishes with a double layer of ﬁ lter paper which was used as an inert material. Then 5 mL of TiO 2 Ag, ZnO+TiO 2 Ag, and EDDS+TiO 2 Ag suspensions were added to every petri dish. Results showed that the maximum SVI was determined at the concentration of 50 mg ∙ L -1 TiO 2 Ag+EDDS for bread wheat and the minimum SVI was observed at 100 mg ∙ L -1 TiO 2 Ag nanoparticles concentration for durum wheat. The effect of both nanoparticles--nanoparticles interaction and the other chemicals-nanoparticles interaction on the ecosystems should be evaluated.
The biology and culture of tropical oysters

Reviews the biology and ecology of oysters, and experimental and culture techniques used in the tropics; describes problems in tropical oyster farming and identifies research needs to further develop this form of aquaculture. Three oyster genera are discussed: Ostrea, Crassostrea and Saccostrea. The advantages and disadvantages of various species of each genus with regard to aquaculture are also described.
Human folate metabolism using 14C-accelerator mass spectrometry

Folate is a water soluble vitamin required for optimal health, growth and development. It occurs naturally in various states of oxidation of the pteridine ring and with varying lengths to its glutamate chain. Folates function as one-carbon donors through methyl transferase catalyzed reactions. Low-folate diets, especially by those with suboptimal methyltransferase activity, are associated with increased risk of neural tube birth defects in children, hyperhomocysteinemic heart disease, and cancer in adults. Rapidly dividing (neoplastic) cells have a high folate need for DNA synthesis. Chemical analogs of folate (antifolates) that interfere with folate metabolism are used as therapeutic agents in cancer treatment. Although much is known about folate chemistry, metabolism of this vitamin in vivo in humans is not well understood. Since folate levels in blood and tissues are very low and methods to measure them are inadequate, the few previous studies that have examined folate metabolism used large doses of radiolabeled folic acid in patients with Hodgkin�s disease and cancer (Butterworth et al. 1969, Krumdieck et al. 1978). A subsequent protocol using deuterated folic acid was also insufficiently sensitive to trace a physiologic folate dose (Stites et al. 1997). Accelerator mass spectrometry (AMS) is an emerging bioanalytical tool that overcomes the limitations of traditional mass spectrometry and of decay counting of long lived radioisotopes (Vogel et al. 1995). AMS can detect attomolar concentrations of 14 C in milligram-sized samples enabling in vivo radiotracer studies in healthy humans. We used AMS to study the metabolism of a physiologic 80 nmol oral dose of 14 C-folic acid (1/6 US RDA) by measuring the 14 C-folate levels in serial plasma, urine and feces samples taken over a 150-day period after dosing a healthy adult volunteer.
Cysteine as a fusion inhibitor in the sexual mating reaction of the green alga Chlamydomonas eugametos

SUMMARY Sexual mating of the biflagellated green alga Chlamydomonas eugametos is initiated by flagellar adhesion. This is followed by the formation of vis-a-vis pairs in which two cells of opposite mating type are connected by a slender cytoplasmic bridge. This neck slowly widens and, finally, zygotes are formed. Vis-a-vis pair formation was reversibly inhibited by cysteine. This effect was only observed when cysteine was present during the first few minutes of mating. Cysteine specifically prevented the protrusion of a plasma papilla between the flagellar bases; other early mating reactions tested were not affected. When cysteine was added to vis-a-vis pairs, the neck did not widen. It is argued that cysteine inhibits an autolysin with a protease character involved in dissolving the cell wall between the flagellar bases during early mating and in widening the neck of vis-a-vis pairs.
Bakterie w kulturach tkanek roslinnych in vitro

Bacterial contamination is quite frequent in plant tissue cultures although, theoretically, cultures have to be axenic. It is their ubiquity and adaptability to different conditions that enable bacteria to colonize also tissue cultures. Among them there are not only the typical endoand egzophytic species connected with the plant kingdom, but also those which are common among people. The bacteria species isolated from plant tissue cultures were found to be vitropathogenic (pathogens facultative to in vitro explants), latent (pathogens not virulent in vitro), and cryptic (present in tissues but invisible). Some bacteria produce growth regulators, which can modify the morphogenetic mode of explants. They are all undesirable ones in cultures, but the explants contaminated with pathogenic species should be eliminated obligatorily. Various groups of bacteria, as well as the techniques of detecting, identifying and eliminating them, are briefly described.
Pressure Fluctuations in Rectangular Cavity Flows

Experiments are performed to study the unsteadiness of rectangular cavity flows at Mach 0.325, 0.620 and 0.818. Typical characteristics of mean surface pressure distributions show a slight pressure variation near the front face, a local peak surface pressure ahead of the rear corner and a low pressure at immediate downstream of the cavity. Larger peak pressure and pressure variation near the cavity rear face are observed as the length-to-depth ratio increases. Surface pressure fluctuation distribution shows an increase toward the cavity rear face and reaches a peak value. At further downstream locations, the level of surface pressure fluctuation approaches the value of incoming flow. The amplitude of peak surface pressure fluctuation is associated with length-to-depth ratio and reaches the maximum at length-to-depth ratio of 8.60. This is considered due to intermittent switching between open- and closed-cavity flows. Higher moments of surface pressure signal at immediate downstream of the cavity show a similar trend. More negative skewness coefficient and larger deviation of flatness coefficient indicate the presence of more large negative events, which is mainly corresponding to mass removal process (breath-out phase). This unsteady mass flow is more pronounced at higher Mach number.
Mosquito (Culicidae) voucher specimens in the RBINS collection: remnants of a past glory or hidden treasure?

In the beginning of the last century mosquitoes were collected extensively all over Belgium. A great part of this material was however never identified and stored in supplements of the Royal Belgian Institute of Natural Sciences (RBINS) collection. The Belgian Culicidae collection at the RBINS was subjected to a new investigation in the framework of the MODIRISK project (an inventory of native and invading mosquito species in Belgium in relation to global change and modelling 2007-2010). The identification and records of all voucher specimens of the collection were evaluated and digitised. One new species for the Belgian fauna was discovered in previously unexplored collection: Culiseta subochrea. None of the currently collected invasive and exotic species were discovered in the collection. Together with many records from other recent inventory projects carried out at the RBINS, a newly established database CULIBEL was generated that included all Belgian mosquito collection records. The present paper demonstrates the importance of extensive voucher specimen collections to basic invertebrate inventory.
Encoder-Decoder Approach to Predict Airport Operational Runway Configuration A case study for Amsterdam Schiphol airport

The runway configuration of an airport is the com- bination of runways that are active for arrivals and departures at any time. The runway configuration has a major influence on the capacity of the airport, taxiing times, the occupation of parking stands and taxiways, as well as on the management of traffic in the airspace surrounding the airport. The runway configuration of a given airport may change several times during the day, depending on the weather, air traffic demand and noise abatement rules, among other factors. This paper proposes an encoder-decoder model that is able to predict the future runway configuration sequence of an airport several hours upfront. In contrast to typical rule-based approaches, the proposed model is generic enough to be applied to any airport, since it only requires the past runway configuration history and the forecast traffic demand and weather in the prediction horizon. The performance of the model is assessed for the Amsterdam Schiphol Airport using three years of traffic, weather and runway use data.