Miracle-dz/UniFAR-FTUs huggingface dataset:
A PCA-LSTM neural network-integrated method for phreatic line prediction

In order to prevent dam ̄breaking accidents of tailings pondsꎬ to excavate effective information of online monitoring system and improve prediction accuracy of phreatic linesꎬ a prediction model was set up based on PCA and LSTM neural network. Thenꎬ with Chenkeng tailings pond as an exampleꎬ Pearson correlation coefficient and variable combination method were introduced to determine 18 features of model inputsꎬ including location of phreatic line of measuring point in the first three daysꎬ location of two adjacent surrounding saturation linesꎬ water level of pondsꎬ longitudinal displacement of dam body and rainfall. Finallyꎬ PCA was used to eliminate data redundancy between input variablesꎬ and LSTM neural 第 3 期 戴健非等: 集成 PCA 和 LSTM 神经网络的浸润线预测方法 network was applied to predict location of phreatic line for the next three days. The results show that PCA ̄ LSTM neural network ̄based method presents higher predication accuracy with an average absolute error of 0􀆰 011 and a decision coefficient of 0􀆰 805. And it can achieve stable prediction of phreatic lines for tailings ponds under different rainfall conditions.
Master Computer Science Learning Context for Weakly-Supervised Action Detection Using Graph Convolutional Networks

This paper concerns the task of detecting and classifying human actions in video. The dominant paradigm for action detection is to learn spatio-temporal features using 2D or 3D Convolutional Networks. We argue that several actions are characterized by their context, such as relevant objects and actors present in the video. To this end, we introduce an architecture based on self-attention and Graph Convolutional Networks in order to model contextual cues, such as human-human and human-object interactions, so as to improve the classiﬁcation of human actions in video for the task of action detection. We are interested in achieving this in a weakly-supervised setting i.e. using as less annotated data as possible in terms of action bounding box annotations. Furthermore, we investigate the ability of our model to explain its predictions by visualizing the learned contextual cues, encoded in the adjacency matrix, as an attention map. We show that our model is able to model relations between the actor and relevant context, even for actions unseen during training. Furthermore, we introduce an evaluation metric, based on recall, to quantitatively evaluate how well the attention highlights the important context. Our model relies on a 3D convolutional single (RGB) stream architecture, and does not require expensive optical ﬂow computation. We evaluate our models on the challenging DALY dataset, which consists of human-object interaction actions and it is suitable for weakly-supervised action detection. Experimental results show that our contextualized approach outperforms a baseline action detection approach by more than 2 points in Video-mAP.
The Role of NF-κ B in ER stress and Its Pathological Implications

The unfolded protein response (UPR) is activated by the endoplasmic reticulum (ER) with the purpose of recovering lost homeostasis due to ER stress. The three branches of this response: IRE1, PERK and ATF6 activate diverse transcriptional programs through different effector mechanisms in a context specific manner. Although UPR is primarily focused on ameliorating the stress produced by misfolded, unfolded or aggregated proteins in the lumen through its canonical activation, the response can change into a more aggressive approach if the initial attempts fail. In such a way, inflammatory pathways can be induced as an alarm that switches to apoptosis if the stress progresses up to an unbearable point for the cell. The family of NF-κB transcription factors are key regulators of critical physiological processes and the chief effector molecules of UPR-induced inflammation. NF-κB can be activated by the three branches of the UPR and target inflammatory genes directed to control increasing apoptotic signals derived from an unmitigated ER stress. This relationship between inflammation and ER stress is critical for the understanding of several pathological conditions that exhibit both phenomena. Diabetes, cancer, cystic fibrosis or some neurodegenerative disorders are some examples of diseases where NF-κB and lost proteostasis converge to shape the observed symptoms and signs. Therefore, understanding the exact molecular mechanisms underlying this crosstalk is pivotal for the comprehension of several diseases. The elucidation of not only these pathways but the complex communication with other organelle compartments and their participation in the expression of a given disease is pivotal for generating efficient therapeutic programs. This work will present some insights into the current understanding of the mentioned routes and how they are involved in the progression of some diseases.
A Novel Conceptual Weighting Model for Semantic Information Retrieval

: Nowadays, the traditional information retrieval (IR) is inadequate for the user who requires precise results. Hence, the importance of the semantic IR arises. It is very important to move from the level of ambiguous terms to that of well-specified concepts in the indexing phase to enrich the search process. To handle the problems of semantic ambiguity of indexed terms as well as the uncertainty and imprecision inherent in the information retrieval process, a semantic indexing approach was proposed for a better document representation. It is based on indexing the associated synsets with document terms that are identified by mapping on the WordNet ontology. These synsets are defined following a term disambiguation process (WSD). The key to the proposed system is a weighting model which calculates the importance of each index item considering many factors that improve the performance of the information retrieval system. Proposed conceptual weight is based on local and global integrality, degree of re-homogenization, and degree of specificity of the concept. A corrector parameter to reduce the impact of errors in WSD process is included. The experimental evaluation of the introduced semantic IR model shows very satisfactory results compared to well-cited benchmarks.
Development and Analysis of Symmetric Encryption Algorithm Qamal Based on a Substitution-permutation Network

—This paper represents a developed cryptographic information protection algorithm based on a substitution-permutation network. We describe the cryptographic transformations used in the developed algorithm. One of the features of the algorithm is the simplicity of its modification with regard to different security levels. The algorithm uses a pre-developed S-box tested against differential and linear cryptanalysis. The S-box is consistent with one of the known standards AES and GOST R 34.12-2015. We provide the findings of an avalanche-effect investigation and statistical properties of ciphertexts. The algorithm actually meets the avalanche-effect criterion even after the first round.
Safety and Feasibility of 48 h Discharge After Successful Primary Percutaneous Coronary Intervention

Background The aim of the current study is to determine the safety of early discharge (ED) within 48 hours (h) for ST-elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (PPCI) and to define the criteria of low-risk patients that can be considered for ED. Methods This is a single-center retrospective study that took place at Mohammed bin Khalifa Cardiac Centre in the Kingdom of Bahrain. 301 patients who underwent PPCI between January 2018 and March 2019 were included. Endpoints at 30 days follow-up comprised cardiac re-admission, cardiovascular death, non-fatal myocardial infarction, stroke, and major adverse cardiovascular and cerebrovascular events. Results Of the 301 patients included in our study, 74 (24.5%) were discharged within 48 h (group 1) compared with 227 (75.5%) hospitalized for more than 48 h after PPCI (group 2) (<0.0001). In terms of baseline characteristics, group 2 had higher proportions of chronic kidney disease (P = 0.051), mean HbA1c (P = 0.016) and mean CPK (P < 0.0001) compared to their group 1 counterparts. The prevalence of anterior STEMI was twice as high among group 2 (P < 0.0001), with a significantly higher prevalence of left main stenting (P = 0.025). Additionally, larger proportion of group 2 required inotropic therapy (P = 0.031), oral anticoagulation (P = 0.005) and had a significantly lower ejection fraction (LVEF) (P < 0.0001) with more procedural complications (P = 0.005). LVEF exerts a large effect on ED, as reflected by a high deviance R2 = 20.4%, and was able to correctly classify the subjects into their pertaining discharge group with an accuracy of 80.4%, a specificity of 82.7%, and a sensitivity of 71.2%. According to the fitted LVEF values using the logistic equation, each 1% increase in LVEF is associated with a 3.5% increase in the chance of ED. The two groups recorded fairly similar clinical outcomes at 30-day. Conclusion Preserved LV systolic function is a good predictor of early and safe discharge after successful PPCI. The presented data support the practice of ED, with length of stay even shorter than current guidelines recommendation in selected low-risk patients.
Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution

Background and Aim: Hypocalcemia in goats occurs around the time of parturition and is caused by decreasing level of calcium less than 10 mg/dL. This investigation characterized the hematological and biochemical profiles of peri-parturient hypocalcemia in goats and study the effects of hypocalcemia on uterine involution during the postpartum period on day 0 and then weekly postpartum (day +7, +14, +21, +28, +35, till +42). Materials and Methods: Forty-five polyparous native breed does age 3-5 years and weighing 40–60 kg were assigned to control and hypocalcemia groups based on their health history, clinical and biochemical findings. The control group included 10 clinically healthy pregnant does, and the hypocalcemia group included 35 late pregnant does that suffered from anorexia, weakness, muscle tremors of the hind limbs, and an inability to stand. Clinical examination and blood sampling in both groups were performed approximately 14 days before the expected time of kidding (day −14), at kidding day (day 0), on day +21, and +42 postpartum. Sonographic measurements were used to monitor uterine involution on day 0 and then weekly once the animal was postpartum (day +7, +14, +21, +28, +35, till +42) in both groups. Results: Results of sonographic measurement revealed that the hypocalcemia group had a greater (p<0.05) size of the uterus as assessed transrectally and retarded uterine involution when compared with the control group. Laboratory findings revealed that does in both groups showed lower red blood cells, packed cell volume%, and hemoglobin (Hb) concentrations on day −14 before kidding and day 0 when compared with postpartum measurements. A significant increase (p<0.05) in total leukocyte counts, neutrophil, serum glucose, and cortisol levels with a significant decrease (p<0.05) in lymphocytes. Significant decreases (p<,0.05) in serum calcium, phosphorous, vitamin D, and total antioxidant capacity levels with significant (p<,0.05) increases in serum malondialdehyde were recorded on day 0 and day −14 in the hypocalcemia group when compared with the control group. Conclusion: This investigation provides evidence that hypocalcemia in does causes both metabolic and oxidative stress during peri-parturient periods while also retarding uterine involution during postpartum periods.
Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines

The development of recombinant COVID-19 vaccines has resulted from scientific progress made at an unprecedented speed during 2020. The recombinant spike glycoprotein monomer, its trimer, and its recombinant receptor-binding domain (RBD) induce a potent anti-RBD neutralizing antibody response in animals. In COVID-19 convalescent sera, there is a good correlation between the antibody response and potent neutralization. In this review, we summarize with a critical view the molecular aspects associated with the interaction of SARS-CoV-2 RBD with its receptor in human cells, the angiotensin-converting enzyme 2 (ACE2), the epitopes involved in the neutralizing activity, and the impact of virus mutations thereof. Recent trends in RBD-based vaccines are analyzed, providing detailed insights into the role of antigen display and multivalence in the immune response of vaccines under development.
Patterns of Body Shape Diversity and Evolution in Intertidal and Subtidal Lineages of Combtooth Blennies (Blenniidae)

Abstract Marine intertidal zones can be harsher and more dynamic than bordering subtidal zones, with extreme and temporally variable turbulence, water velocity, salinity, temperature, and dissolved oxygen levels. Contrasting environmental conditions and ecological opportunities in subtidal versus intertidal habitats may generate differing patterns of morphological diversity. In this study we used phylogenetic comparative methods, measurements of body length, and two-dimensional landmarks to characterize body shape and size diversity in combtooth blennies (Ovalentaria: Blenniidae) and test for differences in morphological diversity between intertidal, subtidal, and supralittoral zones. We found that subtidal combtooth blennies have significantly higher body shape disparity and occupy a region of morphospace three times larger than intertidal lineages. The intertidal morphospace was almost entirely contained within the subtidal morphospace, showing that intertidal combtooth blennies did not evolve unique body shapes. We found no significant differences in body size disparity between tidal zones, no correlations between body shape and tidal zone or body size and tidal zone, and no body shape convergence associated with tidal zone. Our findings suggest that a subset of combtooth blenny body shapes are suitable for life in both subtidal and intertidal habitats. Many species in regions of morphospace unique to subtidal combtooth blennies exhibit distinct microhabitat use, which suggests subtidal environments promoted morphological diversification via evolutionary microhabitat transitions. In contrast, limited intertidal body shape diversity may be due to strong selective pressures that constrained body shape evolution and environmental filtering that prevented colonization of intertidal zones by certain subtidal body shapes.
Knee joint movement and muscle activity changes in stroke hemiplegic patients on continuous use of knee-ankle-foot orthosis with adjustable knee joint

[Purpose] We aimed to evaluate knee joint movement and muscle activity ratio changes in stroke hemiplegic patients in recovery phase after using a knee-ankle-foot orthosis with an adjustable knee joint for 1 month; we also aimed to discuss the practical implications of our findings. [Participants and Methods] The participants were 8 hemiplegic patients in the recovery phase of stroke who were prescribed knee-ankle-foot orthosis with adjustable knee joint. We measured knee joint angles and electromyographic activity of the vastus medialis and biceps femoris during walking in two conditions: the knee-ankle-foot orthosis knee joint fixed in the extended position and the knee joint moved from 0° to 30° in the flexion direction. Measurements were taken 2 weeks after completion to account for habituation of the orthosis and repeated 1 month later. [Results] When the knee joint was moving from 0° to 30° in the flexion direction, the knee joint angle at initial contact and the minimum flexion angle of the gait cycle decreased significantly between the first and second measurements. When knee joint flexion was 30°, the muscle activity ratio of the vastus medialis increased significantly in the loading response and mid-stance compared to when it was fixed. [Conclusion] Setting the knee joint of a knee-ankle-foot orthosis in accordance with the knee joint movement may increase the muscle activity ratio of the vastus medialis from loading response to mid-stance.
The Relationship between Anxiety and Depression Levels with Perceived Stress and Coping Strategies in Health Care Workers during the COVID-19 Pandemic

Objectives: Coronavirus disease (COVID-19) has spread rapidly, locally and internationally after it started in Hubei province of China in December 2019. During the spread of this infectious disease in the world, health care workers are taking place as the main people in the screening and treatment of the disease. The present study aims to evaluate the relationship between anxiety and depression levels with perceived stress and coping strategies in health care workers during the COVID-19 pandemic. Methods: In this study, 200 participants were included. Beck Anxiety Inventory (BDI), Beck Depression Inventory (BDI), Perceived Stress Scale-10 (PSS-10) and COPE (Coping Orientation to Problems Experienced) were applied. Results: Mean scores for BDI and BAI were 9.2±8.9 and 8.2±9.2, respectively. BDI scores of 33 (16.5%) of 200 participants were ≥17. 62% of the participants had minimal depression, 21.5% of the participants had mild depression, 13.5 % of the participants had moderate depression, and 3% of the participants had severe depression according to BDI scores. 60.5% of the participants had minimal anxiety, 25.5% of the participants had mild anxiety, 8.5% of the participants had moderate anxiety and 5.5% of the participants had severe anxiety according to BAI scores. BAI and BDI scores of the female participants were statistically higher than the male participants. A statistically significant positive correlation was found between BAI and BDI scores and PSS-10 scores. A statistically significant difference was found in the averages of BAI and BDI, PSS-10 COPE 3 (Focus on and venting of emotions), 7 (Religious coping) and 13 (Acceptance) subscales levels in occupational groups. A statistically significant difference was found in BDI levels in the clinical units during the pandemic. Conclusion: This study indicated that different coping strategies can be used in health care workers regarding anxiety, depression and stress levels during the COVID-19 pandemic. While problem-solving and emotion-focused adaptive coping mechanisms help reduce symptoms, maladaptive and negative coping mechanisms can cause symptoms to exacerbate. Thus, training should be given to developing attitudes of health care workers to cope with stress.
UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of Bryophyllum pinnatum; antioxidant properties, anticholinesterase activity and in silico studies

Abstract Context Bryophyllum pinnatum (Lam.) Oken (Crassulaceae) is used traditionally to treat many ailments. Objectives This study characterizes the constituents of B. pinnatum flavonoid-rich fraction (BPFRF) and investigates their antioxidant and anticholinesterase activity using in vitro and in silico approaches. Materials and methods Methanol extract of B. pinnatum leaves was partitioned to yield the ethyl acetate fraction. BPFRF was isolated from the ethyl acetate fraction and purified. The constituent flavonoids were structurally characterized using UPLC-PDA-MS2. Antioxidant activity (DPPH), Fe2+-induced lipid peroxidation (LP) and anticholinesterase activity (Ellman’s method) of the BPFRF and standards (ascorbic acid and rivastigmine) across a concentration range of 3.125–100 μg/mL were evaluated in vitro for 4 months. Molecular docking was performed to give insight into the binding potentials of BPFRF constituents against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Results UPLC-PDA-MS2 analysis of BPFRF identified carlinoside, quercetin (most dominant), luteolin, isorhamnetin, luteolin-7-glucoside. Carlinoside was first reported in this plant. BPFRF significantly inhibited DPPH radical (IC50 = 7.382 ± 0.79 µg/mL) and LP (IC50 = 7.182 ± 0.60 µg/mL) better than quercetin and ascorbic acid. Also, BPFRF exhibited potent inhibition against AChE and BuChE with IC50 values of 22.283 ± 0.27 µg/mL and 33.437 ± 1.46 µg/mL, respectively compared to quercetin and rivastigmine. Docking studies revealed that luteolin-7-glucoside, carlinoside and quercetin interact effectively with crucial amino acid residues of AChE and BuChE through hydrogen bonds. Discussion and conclusions BPFRF possesses an excellent natural source of cholinesterase inhibitor and antioxidant. The material could be further explored for the potential treatment of oxidative damage and cholinergic dysfunction in Alzheimer’s disease.
"We don't have up to date knowledge about the disease" Practical challenges encountered in delivery of cervical cancer screening in Iraq.

This qualitative study aimed to explore the lived experience of medical doctors in delivering cervical cancer screening in a city in Iraq. METHODS An applied grounded theory approach explored the reported experiences of doctors in the field. A purposive sample of 12 gynaecologists and one general practitioner (GP) working in two main hospitals participated: Semi-structured interviews took place from June to September 2015. Thematic coding of data was peer reviewed and included participant reading of transcripts and translations from Arabic to English. Theory generation involved synthesis of a prior literature review and interview findings. RESULTS Gynaecologist and GP experiences showed overwhelming gaps in cervical cancer experience and screening. Iraqi women mainly presented for help with late-stage cancer. Practical barriers included cultural stigma, low priority for women's health needs, lack of knowledgeable leadership and perceived shortage of adequately trained staff. CONCLUSION There is an urgent need for culturally appropriate cervical cancer prevention policies and strategies in Iraq, focused on evidence-based population-based cervical screening to identify and prevent advanced cervical cancer among women. Regional educational initiatives should be encouraged and primary healthcare systems supported to undertake screening.