Analysis of a process of peroxidation, caspase-3 and caspase-8 in patients with autoimmune thyroiditis

Sheremet М . І . , Shidlovskyy V. О . , Sydorchuk L. P. Analysis of a process of peroxidation, caspase-3 and caspase-8 in patients with autoimmune thyroiditis. Journal of Education, Health and Sport. 2015;5(11):117-125. ISSN 2391-8306. DOI http://dx.doi. org/10.5281/zenodo.33538 http://ojs.ukw. edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A117-125 https://pbn.nauka. gov.pl/works/667744 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw. edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartośc merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r. , ze w roku 2014 nie bedzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktow co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.09. 2015. Revised 05.10. 2015. Accepted: 30.10. 2015. УДК: 612.017. 1:616.441 ANALYSIS OF A PROCESS OF PEROXIDATION, CASPASE-3 AND CASPASE-8 IN PATIENTS WITH AUTOIMMUNE THYROIDITIS М . І . Sheremet, V. О . Shidlovskyy*, L. P. Sydorchuk Bukovinyan State Medical University, Chernivtsy, Ukraine *I.Y. Horbachevsky State Medical University, Ternopol, Ukraine Abstract The article presents the results of a comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and autoimmune thyroiditis (AIT). While studying the processes of peroxidation in the tissue of the thyroid gland, we revealed that the abnormal tissue is characterized by a significant growth of parameters of protein oxidative modification (POM) at the same time, the activity of antioxidant enzymes (AOE) is significantly reduced, and more likely in patients with AIT. It is shown that in patients with AIT there is a significant increase of activity of caspase 3 and 8 both compared to macroscopically unchanged tissue and to thyroid adenoma. Possible mechanisms of the detected disturbances have been discussed. Key words: autoimmune thyroiditis, thyroid adenoma, apoptosis, peroxidation, caspases 3, 8.