Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifying Critical Control Points in the Wild Oat (Avena fatua) Life Cycle and the Potential Effects of Harvest Weed-Seed Control

Wild oat is a problematic weed species that requires new management techniques in the face of herbicide resistance; harvest weed-seed control (HWSC) may be an option. Wild oat demographic information was collected in long-term, rotational field studies in Lacombe, AB, Canada, in 2006 and 2007, and a periodic matrix model was parameterized using management extremes (no IPM, no herbicide to high IPM, and full herbicide). Population growth rates were calculated for each treatment and year. Prospective (elasticity) and retrospective (LTRE) analyses were conducted alongside a rearrangement of the model equation in which population growth rates were designated and the required proportion of newly shed seed survival that gives that growth rate was solved for. All populations had λ > 1 or increasing populations. Elasticity analyses indicated that λ was most-highly elastic to the overwinter seedbank (Esw = 1), followed by seedling survival, fecundity, and survival of newly shed seed (0.63 to 0.86 across treatments). The latter may be the most-accessible vital rate for management of herbicide resistant populations. LTRE exposed the stochasticity of wild oat population growth rates between years and their ability to take advantage of lapses in control. Decreasing the proportion of newly shed seeds (snew) that survives was the most-effective and available control strategy until reduced to 0.1 to 0.3 when the summer seedbank becomes more critical. When averaged across treatments, > 80% of newly shed seed must be eliminated to stop the population from growing, resulting in a stable population, but not a decline. Because of preharvest shattering, HWSC will likely not be effective enough alone to cause wild oat populations to decline. New management techniques for wild oat control that can be used in combination with HWSC and integrated weed management strategies are needed. Nomenclature: Wild oat, Avena fatua L. AVEFA.
Influence of different phosphoric acids before application of universal adhesive on the dental enamel.

BACKGROUND There are different etching gels available, which have different composition, different pH, and different viscosity, and there is little information in the literature comparing all these products. OBJECTIVE To evaluate the mean microshear bond strength and morphological characteristics of tooth enamel by evaluating different phosphoric acids combined with a universal adhesive system. MATERIALS AND METHODS Eighty-four enamel samples were used, which were divided according to the acid conditioning: G1: Scotchbond Etchant (3M Oral Care), G2: Ultra-Etch (Ultradent), G3: Eco-Etch (IvoclarVivadent), G4: ETCH-37 with BAC (Bisco), G5: Etching gel (Densell), G6: Condac 37 (FGM), and G7: Scotchbond Universal Adhesive (3M Oral Care) in self-etch mode. For the adhesive procedure, Scotchbond Universal Adhesive was the one used as indicated the manufacturer's instructions, 0.9-mm-diameter resin cylinders were placed. The microshear bond strength test was performed after being stored for 24 hours in water. The morphological characteristics of tooth enamel were analyzed using the Raman confocal microscope alpha300RA. The analysis of variance (ANOVA) test and Tukey post-test were used to analyze the differences between the groups. RESULTS The mean microshear bond strength values obtained for groups 1, 4, 5 were significantly greater than groups 2, 3, 6 and 7 (p < .05). All groups presented demineralization after the application of the etching acid, and few signs of demineralization were evident in group 7. CONCLUSIONS Acid-etching with ETCH-37 with BAC, Etching gel, and Scotchbond Etchant improved the adhesive strength in the enamel using an universal adhesive, and acid-etching with Condac 37, Ultra-Etch, and Eco-Etch provides similar adhesive strength values to self-etch mode of universal adhesive. CLINICAL SIGNIFICANCE All acid etchants should be considered as different. The test confirms that enamel etching prior to the application of a universal adhesive system depends on the selected acid etchand product.
Reverse Trigger Phenotypes in Acute Respiratory Distress Syndrome.

RATIONALE Reverse triggering is an underexplored form of dyssynchrony with important clinical implications in patients with Acute Respiratory Distress Syndrome. OBJECTIVES This retrospective study identified reverse trigger phenotypes and characterized their impacts on tidal volume and transpulmonary pressure. METHODS Fifty five patients with Acute Respiratory Distress Syndrome on pressure regulated ventilator modes were included. Four phenotypes of reverse triggering with and without breath stacking and their impact on lung inflation and deflation were investigated. MEASUREMENTS Inflation volumes, respiratory muscle pressure generation and transpulmonary pressures were determined and phenotypes differentiated using Campbell diagrams of respiratory activity. MAIN RESULTS Reverse triggering was detected in 25 patients, 15 with associated breath stacking and 13 with stable reverse triggering consistent with respiratory entrainment. Phenotypes were associated with variable levels of inspiratory effort [mean 4-10cmH2O per phenotype]. Early reverse triggering with early expiratory relaxation increased tidal volumes [88(64-113)ml] and inspiratory transpulmonary pressures [3(2-3)cmH2O] compared with passive breaths. Early reverse triggering with delayed expiratory relaxation increased tidal volumes [128(86-170)ml], increased inspiratory and mean-expiratory transpulmonary pressure [7(5-9)cmH2O, 5(4-6)cmH2O]. Mid-cycle reverse triggering (initiation during inflation and maximal effort during deflation) increased tidal volume [51(38-64)ml], increased inspiratory and mean-expiratory transpulmonary pressure [3(2-4)cmH2O, 3(2-3)cmH2O] and caused incomplete exhalation. Late reverse triggering (occurring exclusively during exhalation) increased mean expiratory transpulmonary pressure [2(1-2)cmH2O] and caused incomplete exhalation. Breath stacking resulted in large delivered volumes [176(155-197)ml]. CONCLUSIONS Reverse triggering causes variable physiological effects, depending on the phenotype. Differentiation of phenotype effects may be important to understand the clinical impacts of these events.
Identifying and managing frailty in a Brazil context: a scoping review protocol.

OBJECTIVE to scope the evidence on how researchers, health and social care professionals in Brazil currently identify and manage frailty in older adults. INTRODUCTION the rapidly aging population and associated increased healthcare usage by older people with frailty are challenging the sustainability of healthcare for older people in Brazil. Understanding how frailty is identified, measured, categorized and managed in Brazil is an important part of building a response to the challenge. INCLUSION CRITERIA this scoping review will consider studies that included Brazilian older adults (≥60 years old) recruited from different settings (community, primary care, health care centers, hospital and long-term care institutions). Studies will be included if they involved any kind of frailty assessment (tools, scales, and measures) and/or interventions. This review will consider all study designs, regardless of their rigor. National policies for older people will be also considered for analysis. METHODS Indexed and gray literature in English or Portuguese from 2001 to the present will be considered. The searches will be conducted using bibliographic databases, university repositories and the Brazilian Government official database. The studies will be independently screened according to the inclusion criteria by two reviewers based on their title, abstract and full text. In case of disagreement, a third reviewer will be consulted. A customized data extraction form will be used to extract data from the included studies. The results will be presented in tabular form, accompanied by a narrative summary related to the objective of the present scoping review.
Establishment of a Rep' protein antibody detection method to distinguish natural infection with PCV2 from subunit vaccine immunization.

Introduction. PCV2 is a DNA virus that exists widely in pigs and has caused great economic losses to the pig industry worldwide. In the existing commercial PCV2 enzyme-linked immunosorbent assay (ELISA) kits both natural infection with PCV2 and vaccine immunization produce results that are positive for PCV2 Cap antibodies and therefore they cannot diagnose PCV2 infection in immunized pig farms.Aim. To establish a PCV2 non-structural protein antibody detection method that distinguishes between antibodies resulting from natural prior exposure (infection) and those induced by subunit vaccine immunization.Methodology. Based on the non-structural Rep' protein, we established an indirect ELISA (iELISA) using sera from guinea pigs and piglets.Results. The results for iELISA for guinea pig serum showed that animals vaccinated with a whole-virus inactivated PCV2 vaccine had 100 % (10/10) Cap antibody positivity and 100 % (10/10) Rep' antibody positivity. Guinea pigs vaccinated with a recombinant subunit PCV2 vaccine had 100 % (10/10) Cap antibody positivity, while no (0/10) guinea pigs were Rep' antibody-positive. The combined detection results for the Rep' iELISA and a PCV2 Antibody Test kit (Commercial) showed that pigs vaccinated with a whole-virus inactivated PCV2 vaccine or PCV2 SD/2017 had 100 % (5/5) Cap antibody positivity and 100 % (5/5) Rep' antibody positivity. Pigs vaccinated with a recombinant subunit PCV2 vaccine had 100 % (5/5) Cap antibody positivity, while no (0/10) pigs were Rep' antibody-positive.Conclusion. This paper describes an effective iELISA method that can distinguish natural infection with PCV2 (Cap and Rep positive) or inoculation with a whole-virus inactivated vaccine (Cap and Rep positive) from subunit vaccine immunization (Cap-positive, Rep-negative). These comparative assays could be very useful in the control of PCV2 in pig herds.
Comparison of Kinect and Leap Motion for Intraoperative Image Interaction

Background. Touchless interaction devices have increasingly garnered attention for intraoperative imaging interaction, but there are limited recommendations on which touchless interaction mechanisms should be implemented in the operating room. The objective of this study was to evaluate the efficiency, accuracy, and satisfaction of 2 current touchless interaction mechanisms—hand motion and body motion for intraoperative image interaction. Methods. We used the TedCas plugin for ClearCanvas DICOM viewer to display and manipulate CT images. Ten surgeons performed 5 image interaction tasks—step-through, pan, zoom, circle measure, and line measure—on the 3 input interaction devices—the Microsoft Kinect, the Leap Motion, and a mouse. Results. The Kinect shared similar accuracy with the Leap Motion for most of the tasks. But it had an increased error rate in the step-through task. The Leap Motion led to shorter task completion time than the Kinect and was preferred by the surgeons, especially for the measure tasks. Discussion. Our study suggests that hand tracking devices, such as the Leap Motion, should be used for intraoperative imagining manipulation tasks that require high precision.
Nonalcoholic fatty liver disease and sarcopenia: pathophysiological connections and therapeutic implications

ABSTRACT Introduction Nonalcoholic fatty liver disease (NAFLD) is currently one of the most common liver diseases worldwide. Recent data suggest that loss of skeletal muscle mass and function (i.e. sarcopenia) is highly prevalent and frequently overlooked in NAFLD patients. Experimental and clinical data suggest that the relationship between NAFLD and sarcopenia is pathophysiologically complex and bi-directional and there is a growing interest in unveiling how sarcopenia could influence NAFLD development and progression. Areas covered PubMed/MEDLINE was searched for articles related to concomitant occurrence of NAFLD and sarcopenia between January 2013 and April 2020. Areas covered in this review include: (1) updated sarcopenia diagnosis strategy, (2) discussion of current data on pathophysiological connections between NAFLD and sarcopenia, and (3) analysis of current and future therapeutic implications of this knowledge. Expert opinion Clinical studies describe a consistent association between NAFLD and sarcopenia, although a cause–effect relation remains to be determined. Active implementation of current diagnosis algorithms and optimized treatment can prevent sarcopenia related complications in subjects with NAFLD. Pathogenic pathways implicated in this relation are multiple and complex, a better understanding of them can provide novel biomarkers and targeted therapies that will hopefully have an important impact in NAFLD management.
Glycogen synthase kinase‐3β inhibits tubular regeneration in acute kidney injury by a FoxM1‐dependent mechanism

Acute kidney injury (AKI) is characterized by injury to the tubular epithelium that leads to the sudden loss of renal function. Proper tubular regeneration is essential to prevent progression to chronic kidney disease. In this study, we examined the role of FoxM1, a forkhead box family member transcription factor in tubular repair after AKI. Renal FoxM1 expression increased after renal ischemia/reperfusion (I/R)‐induced AKI in mouse kidneys. Treatment with thiostrepton, a FoxM1 inhibitor, reduced FoxM1 regulated pro‐proliferative factors and cell proliferation in vitro, and tubular regeneration in mouse kidneys after AKI. Glycogen synthase kinase‐3 (GSK3) was found to be an upstream regulator of FoxM1 because GSK3 inhibition or renal tubular GSK3β gene deletion significantly increased FoxM1 expression, and improved tubular repair and renal function. GSK3 inactivation increased β‐catenin, Cyclin D1, and c‐Myc, and reduced cell cycle inhibitors p21 and p27. Importantly, thiostrepton treatment abolished the improved tubular repair in GSK3β knockout mice following AKI. These results demonstrate that FoxM1 is important for renal tubular regeneration following AKI and that GSK3β suppresses tubular repair by inhibiting FoxM1.
Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation.

Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusion-related deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd), whereas SF1.1. 10 (anti-H-2Kd) does not. In C57BL/6 mice (MHC class I haplotype H-2Kb), TRALI only occurs when anti-MHC class I antibody AF6-88.5. 5.3 (anti-H-2Kb) is administered together with a high dose of 34-1-2S. It remains unknown which specific antibody characteristics are responsible for eliciting TRALI. We therefore investigated several biological and structural features of 34-1-2S compared with other anti-MHC class I antibodies, which on their own do not cause TRALI: SF1.1. 10 and AF6-88.5. 5.3. No substantial differences were observed between the TRALI-causing 34-1-2S and the TRALI-resistant SF1.1. 10 regarding binding affinity to H-2Kd. Regarding binding affinity to H-2Kb, only AF6-88.5. 5.3 potently bound to H-2Kb, whereas 34-1-2S exhibited weak but significant cross-reactivity. Furthermore, the binding affinity to FcγRs as well as the Fc glycan composition seemed to be similar for all antibodies. Similar Fc glycosylation profiles were also observed for human TRALI-causing donor anti-HLA antibodies compared with human anti-HLA antibodies from control donors. 34-1-2S, however, displayed superior complement activation capacity, which was fully Fc dependent and not significantly dependent on Fc glycosylation. We conclude that TRALI induction is not correlated with Fab- and Fc-binding affinities for antigen and FcγRs, respectively, nor with the composition of Fc glycans; but increased Fc-mediated complement activation is correlated with TRALI induction.
The Contribution of Physical Education to Physical Activity Within a Comprehensive School Health Promotion Program

ABSTRACT Purpose: Little is known about the role of physical education (PE) in a school health promotion model, particularly where wellness is placed at the forefront. The purpose of this study was to understand how PE contributes to the overall amount of moderate to vigorous physical activity (MVPA) that children receive in a school recognized for health promotion. Methods: As part of an in-depth case study, participants in grades 4–8 (N = 105) wore ActiGraph wGT3X+ accelerometers over 7 days to assess activity levels. Data were scored using ActiLife software. Using SPSS statistics software, students were grouped into low, moderate, and high activity through calculating tertile splits of average daily MVPA. Two 2 × 2 ANCOVA (sex x activity level) tests were conducted to determine the ratio of MVPA in PE to school and daily MVPA, controlling for age. Results: Participants accrued 8 min MVPA on average during PE with differences among low (6.4 ± 2.5), moderate (8.3 ± 3.7), and highly active participants (10.1 ± 4.0). ANCOVA analyses revealed non-significant interactions between sex and activity level explaining variance in contribution of PE to school MVPA (F(2, 99) = . 235, p = . 791, partial ŋ2 = . 005) and daily MVPA (F(2, 99) = . 299, p = . 742, partial ŋ2 = . 006), but significant main effects between high and low activity for daily MVPA were observed F(2, 99) = 5.118 p = . 008, partial ŋ2 = . 094. Conclusions: PE remains a priority in supporting children’s PA, particularly for those least active. Despite relatively low levels of MVPA, findings provide rationale for policy change supporting more frequent PE in schools.
Brooding in the Southern Ocean: The Case of the Pterasterid Sea Star Diplopteraster verrucosus (Sladen, 1882)

Diplopteraster verrucosus is a sea star that incubates its offspring in nidamental chambers. The offspring rely exclusively on maternally provided nutrition. The retention of the embryonic stages allows the allocation of nutritional supplies from the female to the brooded juveniles during the brooding period. The main objectives of this study are, first, to quantify the reproductive investment of D. verrucosus and, second, to describe the morphology, energetics, and oxidative metabolism throughout early ontogenetic stages. A skewed sex ratio of 2:1 females:males was found, and 17 of 39 females were brooding. Both brooding and non-brooding females showed higher energy density and total antioxidant capacity in their gonads than males. We identified three cohorts of offspring being retained within the female body simultaneously. Energy density and reactive oxygen species increased significantly with the offspring’s volume throughout ontogeny. Moreover, we found evidence of at least two key events during ontogeny. First, the depletion of antioxidants, the increase of reactive oxygen species, and the development of a complete digestive system appear to trigger feeding on the mothers’s pyloric caeca. Second, another oxidative imbalance appears to be associated with the release of the brooded juveniles to the environment. Therefore, oxidative balance and energetic variances may be associated with development of autonomous feeding and juvenile release in D. verrucosus.
A many-objective evolutionary algorithm based on decomposition with dynamic resource allocation for irregular optimization

The multi-objective optimization problem has been encountered in numerous fields such as high-speed train head shape design, overlapping community detection, power dispatch, and unmanned aerial vehicle formation. To address such issues, current approaches focus mainly on problems with regular Pareto front rather than solving the irregular Pareto front. Considering this situation, we propose a many-objective evolutionary algorithm based on decomposition with dynamic resource allocation (MaOEA/D-DRA) for irregular optimization. The proposed algorithm can dynamically allocate computing resources to different search areas according to different shapes of the problem’s Pareto front. An evolutionary population and an external archive are used in the search process, and information extracted from the external archive is used to guide the evolutionary population to different search regions. The evolutionary population evolves with the Tchebycheff approach to decompose a problem into several subproblems, and all the subproblems are optimized in a collaborative manner. The external archive is updated with the method of shift-based density estimation. The proposed algorithm is compared with five state-of-the-art many-objective evolutionary algorithms using a variety of test problems with irregular Pareto front. Experimental results show that the proposed algorithm out-performs these five algorithms with respect to convergence speed and diversity of population members. By comparison with the weighted-sum approach and penalty-based boundary intersection approach, there is an improvement in performance after integration of the Tchebycheff approach into the proposed algorithm.