Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethical, regulatory, and practical barriers to COVID-19 research: A stakeholder-informed inventory of concerns

Introduction SARS-CoV-2 (COVID-19) has caused death and economic injury around the globe. The urgent need for COVID-19 research created new ethical, regulatory, and practical challenges. The next public health emergency could be worse than COVID-19. We must learn about these challenges from the experiences of researchers and Research Ethics Committee professionals responsible for these COVID-19 studies to prepare for the next emergency. Materials and methods We conducted an online survey to identify the ethical, oversight, and regulatory challenges of conducting COVID-19 research during the early pandemic, and proposed solutions for overcoming these barriers. Using criterion-based, convenience sampling, we invited researchers who proposed or conducted COVID-19 research to complete an anonymous, online survey about their experiences. We administered a separate but related survey to Institutional Review Board (IRB) professionals who reviewed COVID-19 research studies. The surveys included open-ended and demographic items. We performed inductive content analysis on responses to open-ended survey questions. Results IRB professionals (n = 143) and researchers (n = 211) described 19 types of barriers to COVID-19 research, related to 5 overarching categories: policy and regulatory, biases and misperceptions, institutional and inter-institutional conflicts, risks of harm, and pressure of the pandemic. Researchers and IRB professionals described 8 categories of adaptations and solutions to these challenges: enacting technological solutions; developing protocol-based solutions; disposition and team management; establishing and communicating appropriate standards; national guidance and leadership; maintaining high standards; prioritizing studies before IRB review; and identifying and incorporating experts. Discussion and conclusions This inventory of challenges represents ongoing barriers to studying the current pandemic, and they represent a risk to research during future public health emergencies. Delays in studies of a pandemic during a pandemic threatens the health and safety of the public. We urge the development of a national working group to address these issues before the next public health emergency arises.
Comparison of parameters derived from a three-minute all-out test with classical benchmarks for running exercise

This study aimed to compare four constructs from the three-minute all-out test (AO3)–end power (EP), the area above EP (WEP), maximum power (Pmax), and attained V˙O2peak−to those derived from the classical CP model in tethered running. Seventeen male recreational runners underwent two experiments to test for reliability and agreement of AO3 parameters with those obtained from the classical CP model (Wꞌ and CP), a graded exercise test (V˙O2max) and a 30-second all-out test (AO30s; Pmax); all performed on a non-motorized treadmill (NMT). Significance levels were set at p<0.05. There were no significant differences between test-retest for Pmax (p = 0.51), WEP (p = 0.39), and EP (p = 0.64), showing generally close to zero bias. Further, retest ICC were high for Pmax and EP (ICC > 0.86) but moderate for WEP (ICC = 0.69). Pmax showed no difference between AO3 and AO30s (p = 0.18; CV% = 9.5%). EP and WEP disagreed largely with their classical critical power model counterparts (p = 0.05; CV%>32.7% and p = 0.23; CV%>39.7%, respectively), showing greater error than their test-retest reliability. V˙O2peak from AO3 was not different (p = 0.13) and well related (CV% = 8.4; ICC = 0.87) to the incremental test V˙O2max. Under the studied conditions, the agreement of EP and WEP to CP and Wꞌ was not strong enough to assure their use interchangeably. Pmax and V˙O2max were closer to their criterion parameters.
Evaluation of a whole system approach to diet and healthy weight in the east of Scotland: Study protocol

Obesity is a global epidemic affecting all age groups, populations and income levels across continents. The causes of obesity are complex and are routed in health behaviours, environmental factors, government policy and the cultural and built environment. Consequently, a Whole System Approach (WSA) which considers the many causes of obesity and shifts the focus away from individuals as points of intervention and puts an emphasis on understanding and improving the system in which people live in is required. This protocol describes a programme of research that will: critically evaluate the evidence for WSAs; assess longitudinally the implementation of a WSA to diet and healthy weight to explore the range of levers (drivers) and opportunities to influence relevant partnerships and interventions to target obesity in East Scotland. The programme consists of four workstreams within a mixed methods framework: 1) Systematic review of reviews of WSAs to diet and healthy weight; 2) Longitudinal qualitative process evaluation of implementing two WSAs in Scotland; 3) Quantitative and Qualitative momentary analysis evaluation of a WSA; and 4) the application of System Dynamics Modelling (SDM) methodology to two council areas in Scotland. A Public Involvement in Research group (PIRg) have informed each stage of the research process. The research programme’s breadth and its novel nature, mean that it will provide valuable findings for the increasing numbers who commission, deliver, support and evaluate WSAs to diet and healthy weight nationally and internationally.
Chikungunya virus time course infection of human macrophages reveals intracellular signaling pathways relevant to repurposed therapeutics

Background Chikungunya virus (CHIKV) is a mosquito-borne pathogen, within the Alphavirus genus of the Togaviridae family, that causes ~1.1 million human infections annually. CHIKV uses Aedes albopictus and Aedes aegypti mosquitoes as insect vectors. Human infections can develop arthralgia and myalgia, which results in debilitating pain for weeks, months, and even years after acute infection. No therapeutic treatments or vaccines currently exist for many alphaviruses, including CHIKV. Targeting the phagocytosis of CHIKV by macrophages after mosquito transmission plays an important role in early productive viral infection in humans, and could reduce viral replication and/or symptoms. Methods To better characterize the transcriptional response of macrophages during early infection, we generated RNA-sequencing data from a CHIKV-infected human macrophage cell line at eight or 24 hours post-infection (hpi), together with mock-infected controls. We then calculated differential gene expression, enriched functional annotations, modulated intracellular signaling pathways, and predicted therapeutic drugs from these sequencing data. Results We observed 234 pathways were significantly affected 24 hpi, resulting in six potential pharmaceutical treatments to modulate the affected pathways. A subset of significant pathways at 24 hpi includes AGE-RAGE, Fc epsilon RI, Chronic myeloid leukemia, Fc gamma R-mediated phagocytosis, and Ras signaling. We found that the MAPK1 and MAPK3 proteins are shared among this subset of pathways and that Telmisartan and Dasatinib are strong candidates for repurposed small molecule therapeutics that target human processes. The results of our analysis can be further characterized in the wet lab to contribute to the development of host-based prophylactics and therapeutics.
A study on validating KinectV2 in comparison of Vicon system as a motion capture system for using in Health Engineering in industry

Abstract The currently available commercial motion capture systems are constrained by space requirement and thus pose difficulties when used in developing kinematic description of human movements within the existing manufacturing and production cells. The Kinect sensor does not share similar limitations but it is not as accurate. The proposition made in this article is to adopt the Kinect sensor in to facilitate implementation of Health Engineering concepts to industrial environments. This article is an evaluation of the Kinect sensor accuracy when providing three dimensional kinematic data. The sensor is thus utilized to assist in modeling and simulation of worker performance within an industrial cell. For this purpose, Kinect 3D data was compared to that of Vicon motion capture system in a gait analysis laboratory. Results indicated that the Kinect sensor exhibited a coefficient of determination of 0.9996 on the depth axis and 0.9849 along the horizontal axis and 0.2767 on vertical axis. The results prove the competency of the Kinect sensor to be used in the industrial environments.
Cryopreservation and Flow Cytometric Analysis of Ovarian Tissue in Murray River Rainbowfish, Melanotaenia fluviatilis

Simple Summary Freshwater fish populations are in global decline, with many Australian freshwater species expected to become extinct in the next twenty years. The storage of reproductive cells and tissues at extremely cold temperatures in bio-banks known as “Frozen Zoos”, allows for the indefinite storage of genetic material, meaning that in the event of an extinction, we have a genetic blueprint available to produce new individuals and reintroduce a species into the wild. Here we have developed a cryopreservation protocol for the storage of ovarian tissue from the threatened Murray River Rainbowfish. Many Australian freshwater fish species are threatened with extinction, our methodology provides a framework for the conservation of other fish species in Australia and globally. Abstract Freshwater fish populations are declining with many small, Australian fish species at risk of extinction within the next twenty-years. Cryopreservation of reproductive cells and tissues makes it possible to reproduce individuals from a species even after they are extinct in the wild. We describe the successful cryopreservation of ovarian tissue in the Murray River Rainbowfish, Melanotaenia fluviatilis (Order: Atheriniformes). Histology showed that oogonia are 13.70 µm ± 1.75 µm in size, stain positive for germ-line marker Vasa, and represent approximately 2.29 ± 0.81% of cells in the ovary. Flow cytometry was used to analyse ovarian cell suspensions, requiring an optimised tissue digestion protocol. We found that 0.25% trypsin with 1.13 mM EDTA produced cell suspensions with the highest viability (76.28 ± 4.64%) and the highest number of cells recovered per gram of tissue (1.2 × 108 ± 4.4 × 107 cells/g). Subsequent sorting of ovarian cell suspensions by flow cytometry increased oogonial cells in suspension from 2.53 ± 1.31% in an unsorted sample to 5.85 ± 4.01% in a sorted sample (p = 0.0346). Cryopreservation of ovarian tissue showed DMSO-treated samples had higher cell viability post-thaw (63.5 ± 18.2%) which was comparable to fresh samples (82.5 ± 7.1%; p = 0.36). Tissue cryopreserved in 2.0 M DMSO had the highest cell viability overall (76.07 ± 3.89%). This protocol could be applied to bio-banking programs for other species in the Melanotaeniidae, and perhaps species in other families and orders of Australian fish.
A planar wideband 2‐D beam‐forming network for multibeam application

This article presents a wideband 2‐D beam‐forming network (BFN) utilizing a three‐layer strip‐line structure, which has 16 input ports and 16 output ports. The BFN, composed of multiple 2‐D couplers, crossovers, and phase shifter groups, can provide an equal power signal distribution with ±45° or ±135° phase differences between the adjacent output ports, hence achieving 2‐D beam scanning in both azimuth and elevation planes. To validate the concept, a prototype operating in the frequency range of 2.25–3.75 GHz is fabricated, measured, and discussed. The measurement results coincide well with the simulation ones.
Web Content Analysis On Sustainable Campus Operation (SCO) Initiatives

The purpose of this paper is to identify and analyse the current practices implemented in global universities for achieving sustainability throughout campus operations. This study adopted a web content analysis method where 30 international green universities’ websites have been thoroughly examined to identify common initiatives implemented to achieve sustainability through campus operations. The findings are ranked based on the implementation of these initiatives by participating universities. From the websites reviewed, as much as 31 initiatives have been identified as common initiatives frequently implemented by green universities to achieve sustainability in campus operations. It was found that the common initiatives frequently implemented by most of the universities include ‘Provide bin with clearly marked signs to increase the number of recycling items’, and ‘Generate electricity on campus by establishing power generation plants’ with 87% and 83% respectively. This paper fills the gap by presenting the investigation of sustainability initiatives from some of the major green universities internationally. It is suggested that higher education institutions, particularly Malaysian universities, initiate or manage their implementation of sustainable campus operation (SCO) initiatives based on the findings of this research.
Water Environment Federation Sustainability

This review on Sustainability covers selected 2014 publications on the focus of the following sections:  Sustainable water and wastewater utilities  Sustainable water re sources management  Stormwater and green infrastructure  Sustainability in wastewater treatment  Life cycle assessment (LCA) applications  Sustainability and energy in wastewater industry,  Sustainability and asset management doi: 10.2175/106143015X14338845155705 1 College of Environmental Scie nce and Engineering. Guilin University of Technology, Guilin 541004, China *Corresponding author, Email: 646761963@qq.com 2 Department of Engineering a nd Technical Services, DC Water and Sewer Authority, Washington, DC 20032, USA 3 Department of Civil and Environmental Engineering, Villanova University, Villanova, PA 19085, USA 4 Solid Waste Management Station of Hunan Province, Department of Environmental Protection of Hunan Province, Changsa, Hunan , China 5 School of Environment, Beijing Normal University , Beijing 100875, China Sustainable Water and Wastewater Utilities Rehan et al. (2014a) de v loped a wastewater system dynamics model as a decision support tool that can assist utility managers to en sure financial sustainability while maintaining customer expectations for service performance. To achieve impl ementation of the model, a demonstration case study is developed using data from a medium-sized city in Ontari o, Canada, having a large backlog of deteriorated wastew ater pipes. Results indicate that a financing strategy involving borrowing can minimize the total life-cycle cost while maximizing the service performance level of the network. Rehan, et al. (2014b) also developed causal loop diagrams for wastewater collection networks to identify complex interactions and feedback l oops among physical, financial, and social sectors. Causal loop diagrams are then incorporated into a novel system dynamics based decision support tool that can be used for financially sustainable management of wastewater collection networks. The system dynamics model is the first known decision support tool to quantitatively simulate the influence of interrelationships and feed back loops in wastewater collection network management . The model can be used to develop shortand long-te rm management plans. The impact of financing and rehabilitation strategies on system
Portrayals of narcolepsy from 1980 to 2020: a descriptive analysis of stigmatizing content in newspaper articles.

STUDY OBJECTIVES The media are the primary source of information about health for the public. The media portrayal of narcolepsy might contribute to the stigmatization of people affected by this condition. This study aimed to describe how narcolepsy is portrayed in newspapers. METHODS We collected 257 newspaper articles from the digital archive of "La Stampa" published between 1980 and 2020 that mentioned key search terms. The content was assessed using an ad-hoc coding schema developed to evaluate the presence of sensationalistic title, negative language, stigmatizing content, stereotypical description, disclosure of a person diagnosed with narcolepsy, person with narcolepsy described as dangerous, presence of an accurate diagnosis, identifiable symptoms, indications about diagnostic and treatment services. The Chi-squared analysis was performed to identify changes over time in the type of content. RESULTS In 10.9% of the articles, there was a sensationalistic title; inappropriate, negative, and outdated language appeared in 10.5% of the articles. Stigmatizing and stereotypical content were reported in 19.5% and 14.8% of the articles, respectively. In 62.3% of the articles, it was disclosed that a person has narcolepsy, and in 5.1% of the articles patients with narcolepsy are described as dangerous. 30.4% of the articles referred to the presence of an accurate diagnosis, while 16.7% described identifiable symptoms. Services for diagnosis and treatment were mentioned in 24.1% of the articles. Changes over time in the content of articles are discussed. CONCLUSIONS Our findings highlight areas for improvement in the media portrayal of narcolepsy and could help guide the development of new targeted antistigma campaigns.
Does Alcohol Consumption Influence People’s Perceptions of Their Own and a Drinking Partner’s Ability to Consent to Sexual Behavior in a Non-sexualized Drinking Context?

The purpose of this study was to examine the extent that alcohol consumption affected participants’ perceptions of their own and their friend’s ability to consent to sex in a non-bar drinking environment. We interviewed 176 people at tailgates in dyads about their own and their friends’ alcohol consumption, intoxication symptoms, and ability to consent. Participants reported consuming a mean of 4.6 drinks and had a breath alcohol concentration (BrAC) of . 075 on average, but few thought they or their friend had diminished cognitive function. Accordingly, 92.6% indicated they could consent to sex and 81.8% indicated their friend could consent to sex. Number of drinks people reported consuming, self-reported intoxication levels and symptoms, and BrACs were not significantly related to participants’ perceptions of their own or their friends’ ability to consent to sex. However, gender pairing of the dyad was significant; those in man–man pairs were more likely than those in woman–woman pairs to indicate their friend could consent and they would allow their friend to have sex if approached by an interested party. Participants also indicated that they did not perceive themselves or their friends to be “too intoxicated” as common reasons why they believed they and their friend could consent. Because alcohol-facilitated sexual assault is common among college students, we recommend sexual assault prevention educators focus on raising awareness regarding alcohol’s negative cognitive effects, particularly related to consent communication.
Tranexamic Acid Microinjection Alone Versus Its Combination With Fractional Carbon Dioxide Laser in Melasma Treatment: A Dermoscopic Evaluation

BACKGROUND Melasma is a challenging pigmentation disorder. OBJECTIVE To assess and compare the efficacy of tranexamic acid (TXA) intradermal microinjection alone versus its combination with low-power, low-density fractional CO2 laser in a sequential pattern in melasma. Patients and Methods This study included 29 patients with melasma. Half of the face was randomly assigned to fractional CO2 laser; the other half to TXA. This split-face session was repeated every 6 weeks for 3 sessions. In between, TXA was applied to the full face every 2 weeks. Treatment duration was 4 months. Dermoscopy, melanin index (M.I), and erythema index (E.I) were evaluated at baseline and 4 weeks after the last session. RESULTS Melanin index, E.I, total dermoscopic score and different dermoscopic patterns of pigmentation, and vascular features showed significant reduction posttreatment on both sides of the face. No statistically significant difference was found regarding the degree and percentage of improvement in M.I, E.I, and total dermoscopic score between both sides. CONCLUSION Tranexamic acid microinjection alone or combined with low-power, low-density fractional CO2 laser in a sequential pattern are comparatively effective and safe for melasma treatment; however, combined treatment is recommended. Dermoscopy is an essential noninvasive tool in the assessment of melasma and monitoring patients' response to treatment.
Perspective: Is it Time to Expand Research on “Nuts” to Include “Seeds”? Justifications and Key Considerations

ABSTRACT The health benefits of nuts reported throughout the literature are extensive and well established for reducing the risk of, and managing several chronic conditions such as cardiovascular disease, type 2 diabetes, nonalcoholic fatty liver disease, and cognition. Despite their comparable nutrient profile to nuts, seeds are often not assessed in clinical and epidemiological studies. Interestingly, dietary guidelines and recommendations often refer to “nuts and seeds” collectively, even though they are not consistently examined together in nutrition research when determining associated health benefits. The purpose of this review is to call for future nutrition research to consider combining nuts and seeds. This review provides justification for this proposal by summarizing current definitions for nuts and seeds and highlighting the similarities or dissimilarities in their nutrient compositions. Following this, we summarize current evidence on the health benefits of nuts and seeds, research gaps that should be addressed, and considerations for future research using both epidemiological and interventional study designs.
Meeting the Challenge of Work and Life Using a Career Integrated Learning Approach

The Career Integrated Learning project is focused on encouraging students to articulate the graduating student attributes or competencies (GSC) they may gain through their university curriculum. Competencies that will help them ease their transition to the world of work of further graduate studies. Students develop those competencies through their experiences in the classroom, work based programs and community involvement. By identifying and articulating the broader skills and attributes acquired through completion of a degree, students can readily make a clear connection to the workplace. The concept of identifying GSC is not new, especially for students who participate in experiential learning activities. What is innovative about this project is translating the process to classroom-based courses, especially in Arts and Science faculties. This article describes the process of identifying competencies in collaboration with instructors and helping students reflect on those competencies as they complete courses.