Miracle-dz/UniFAR-FTUs huggingface dataset:
MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3

Background: MicroRNAs (miRNAs) play important roles in the occurrence and development of cancers. In this project, we aimed to explore the role and molecular mechanism of mir-30a-5p in cholangiocarcinoma (CCA). Materials and Methods: The expression profile and clinical significance of miR-30a-5p in CCA patients were investigated in 31 ICC and 52 ECC patients respectively. The role and mechanism of miR-30a-5p in CCA cells were investigated by up-regulating and inhibiting miR-30a-5p expression in vitro functional study. Results: The expression of miR-30a-5p was increased in both CCA tissues and cells. The inhibition of miR-30a-5p decreased cell proliferation and induced cell apoptosis while overexpression of miR-30a-5p achieved the opposite effect. Furthermore, SOCS3 was down-regulated in ICC and ECC tissues and negatively regulated by miR-30a-5p. Dual-luciferase reporter assay revealed that co-transfection of miR-30a-5p significantly inhibited the activity of firefly luciferase reporter carrying the wild-type 3′UTR of SOCS3. The inhibition of SOCS3 could largely rescue the inhibitory effect of miR-30a-5p inhibition on CCA cells proliferation. In clinical, up-regulated miR-30a-5p expression was correlated with large tumor size in both ICC and ECC cohorts. Conclusions: miR-30a-5p promoted CCA cells proliferation through targeting SOCS3. These findings suggested that miR-30a-5p could be a potential therapeutic target.
ETHICS IN THE CONSERVATION AND RESTORATION OF EARLY BRASS INSTRUMENTS

T he intention of this paper is to discuss some aspects of the preservation of brass instruments in museum collections and to contrast these with the restoration needs of working instruments. From experiences over the last few. decades it has become clear that the opening statement of Preservation and Restoration of Musical Instruments, that "Where possible the restoration of a deteriorated instrument is commendable" (see Recommended Reading), can no longer be supported in a museum context. Discussions on musical instrument care have centered on the problems of restoration vs. conservation and it has become evident that restoration of instruments in the public domain has, in many cases, resulted in irreversible damage to unique examples and significant loss of historical evidence. The same is true in the private sector and, although a clear distinction exists between the practices of private owners and restorers of musical instruments and those expected of personnel working in and for museum collections, the compromises to the integrity of the instruments in both domains remain an unfortunate constant. Before proceeding much further it would be wise to define what we understand the terms "conservation" and "restoration" to mean. In almost all non-English speaking countries the term "conservation" applies to the domain of the curator, while the staff member who treats objects, regardless of the ethical and technical status of the work, is engaged in restoration. To the contrary, in the Englishspeaking world, conservation as a descriptor originated as a result of purely ,,preventive treatment applied to archaeological objects. It attempted to distinguish between the technical preservation of fragile and unstable artifacts and what was then perceived to be the less thoughtful and more wholesale beautification of museum pieces for display. Even though the bona fide discipline of conservation came into being half a century ago, and came to embrace the treatment of all museum objects, it is still not well understood. I know a curator who still persists in calling people in my profession "conservationists" (perhaps a step up from restorers) and I have yet to find a journalist who though conservation was not concerned with acid rain and endangered species. Speak of restoration and they all know where you stand. The International Council of Museums (ICOM), when given an opportunity to clarify once and for all the distinction, opted for the portmanteau term conservator/restorer, which advances
Specific Binding Properties of Mongolian Milk Whey Proteins to Hydrophobic Molecules as Lipocalin

Takanori Satoh1,2,*, Narumi Maegawa1, Natsumi Yoshioka1, Mayu Kanamoto1, Yui Hamaji1, Zesem Ichinkhorloo3, Ganbat Orgilbayar3, Logii Narantsetseg3, Janlav Munkhtsetseg3 and Makoto Ohashi1 1Faculty of Integrated Arts and Sciences, Tokushima University, Minami-josanjima cho 2-1, Tokushima city, Tokushima, Japan 2Faculty of Science and Engineering, Tokushima University, Minami-josanjima cho 2-1, Tokushima city, Tokushima, Japan 3Department of Biochemistry and Laboratory, School of Bio-Medicine, Health Sciences University of Mongolia, Ulaanbaatar 210648, Mongolia
Fatigue-crack growth in fresh-water prelitninary results

Very little data exist on the fatigue behavior of ice, yet fatigue may have an important role to play in a number of ice failure situations. Whilst reversed-bending tests and cyclic-compression tests have been performed on ice, no attempts have been made previously to measure fatigue-crack growth rates in ice. This paper presents the results of fatigue-crack growth experiments on S2 (i.e. columnar grained with the c axes randomly aligned within the horizontal plane) fresh-water ice. There is clear evidence that crack growth has occurred under cyclic loading but, as yet, the data are insufficient to determine the validity of dajdN versus oK type behavior. Preliminary results are presented and the implications of the results are discussed.
Analysis of genetic diversity in banana cultivars (Musa cvs.) from the South of Oman using AFLP markers and classification by phylogenetic, hierarchical clustering and principal co..

Banana is an important crop grown in Oman and there is a dearth of information on its genetic diversity to assist in crop breeding and improvement programs. This study employed amplified fragment length polymorphism (AFLP) to investigate the genetic variation in local banana cultivars from the southern region of Oman. Using 12 primer combinations, a total of 1094 bands were scored, of which 1012 were polymorphic. Eighty-two unique markers were identified, which revealed the distinct separation of the seven cultivars. The results obtained show that AFLP can be used to differentiate the banana cultivars. Further classification by phylogenetic, hierarchical clustering and principal component analyses showed significant differences between the clusters found with molecular markers and those clusters created by previous studies using morphological analysis. Based on the analytical results, a consensus dendrogram of the banana cultivars is presented.
Influence of Computer Literacy Skills on OPAC Use by Undergraduates in two Universities in Nigeria

This paper ascertains the extent to which undergraduates in two federal university libraries in Nigeria are computer literate and how their computer literacy level has affected their use of Online Public Access Catalog (OPAC). Level of undergraduates’ computer literacy in both universities studied was high but their level of OPAC use was low. OPAC-compliant universities in Nigeria should identify reasons for low use of OPAC among their undergraduates and strategies should be placed to tackle them. Policies to encourage high level of OPAC use among undergraduates should be implemented by university libraries. Awareness programmes should be sustained to improve undergraduates’ level of OPAC use.
Pregnant Women Priority of Choices about Mode of Delivery: A Mixed Method Study

Background: Near about thirty years ago, there has been a significant raise in caesarean section (CS) rates in middleand developed countries all over the world. CS rates persist to increase in spite of data that there is no related enhancement to women or babies health; to a certain extent, CS be able to raise the hazard of complications, such as maternal mortality, reproductive tract injuries. There is data that few women truly prefer CS. The study aimed to explore the prevalence of the preferences of pregnant women regarding mode of delivery. A further aim was to identify associated factors and look into reasons for the preference. Methods: A mixed methods design was used. Utilizing a mixed methodology, a self-administered questionnaire was distributed to (473) women and nine in-depth semi-structured interviews with mothers. The response rate was 83% which represented (394) women attending antenatal clinics between June 20 and August 20,2017 in the university maternity and child health hospital, Minia, Egypt. Results: Quantitative findings of the study showed that the mean age of the respondents was 31.6. Less than half (45.4%) of the respondents referred their preference to CS to the trust on the physician experience. With regards to "Reasons for preference of vaginal delivery", 40.6% mentioned that the recovery is faster/better, whereas, 40.1% were for no scar. There were 35.8% said it is a natural process and 34.8% were for no complications. About 24.4% were for less stay in the hospital, while, 22.3% were for less pain. Qualitative findings showed that there are three major themes identified in the study. The first theme is "Ideas". It has three subthemes. The second theme is "Future plans". While, the third theme is "Needs". Conclusion: Preference of the mode of delivery is personal and medical in nature. This means that individual decision should be taken into consideration rendering patient centered care to the pregnant woman during labor. Also, maternal and fetal medical condition should be manage properly.
EDUCOEF An Expert System providing District-Specific Diagnostics for Educational Enrollment Problems in Africa

Introduction In many parts of Africa, educational participation of children and especially of girls is too low. Policy makers who want to improve this situation often lack the knowledge needed for developing tailor-made policy interventions. The available scientific knowledge on factors that influence participation is often too crude and too general to be of use in specific situations. Qualitative information on the causes of non-enrollment provided by field workers is often not reliable enough to base policy measures upon. EDUCOEF is a newly developed Expert System that derives district-level information from available household-level datasets and translates it into a form that is understandable, accessible and usable by policy makers. The Expert System provides them with districtlevel diagnostics that provides insight into the causes of educational non-participation of children. EDUCOEF can be accessed through the internet and is equipped with an interface through which the information is made available in an understandable form. In the next sections I will first explain how EDUCOEF works and what can be done with it. Then I will give an overview of the risk factors included in it. The second part of the paper consists of a user guide that provides interested policy makers and other users with the information they need to derive information from EDUCOEF and on the meaning of the coefficients provided by it.
Chronic Disease Self Management Program ( CDSMP ) Impacts Perceived Health Status For Underserved Rural Clients

Background: Despite growing recognition that chronic disease management is a vital health care issue, success in the management of chronic disease has been limited. Switching from palliative medical model to a participatory and preventionbased approach may provide a roadmap to meet today’s health care challenges. Purpose: To determine whether participation in the Chronic Disease Self Management Program (CDSMP) significantly improved underserved rural participant’s outcomes. Methods: A quasi-experimental pre-test, post-test design the intervention was tested with a convenience sample of 48 rural, underserved, poor community members with chronic disease at two subsidized clinics for the working poor. The study examined if participation in a CDSMP improved multiple post-program outcomes in this population. The sample, recruited from two rural clinics in a south central state, consisted of 48 middle and older adults (59.70+/-11.22 years) and was 79.2% Caucasian (n=38) and 20.8% (n=10) African American. Results : The conceptual framework, process, content of the intervention as well as the feasibility and acceptability of study materials and methods, and effects of the intervention are reported. Significant improvements in perceived health status were noted on the health distress (p<.01) and energy/fatigue (p=.01) scales. Conclusions: Study results accentuate the importance of evaluating intervention programs for specific populations and for a new practice exemplar that focuses on patient-provider partnerships that can meaningfully improve health outcomes in underserved, poor, rural populations.
Ad Astra Academy: Using Space Exploration to Promote Student Learning and Motivation in the City of God, Rio de Janeiro, Brazil

5 CAPjournal, No. 27, March 2020 Some factors that contribute to student motivation are relatively well-established. Past work has demonstrated the importance of competence, autonomy, and relatedness through the framework of self-determination theory (Deci & Ryan, 2000), revealing the benefits of metacognition to keep track of progress (Zepeda, 2015) and highlighting the value of a growth mindset in building resilience and sustained academic interest (Dweck, 2016). Similarly, the expectancy-value theory (Wigfield & Eccles, 2000) has shown that students’ achievement on a task depends on the subjective value that students assign to it, and whether they expect to succeed.
Solidification Structure and Tensile Properties of 2014 Aluminum Alloy Welds

Plates of 2014 aluminum alloy of two different thicknesses were joined using gas tungsten-arc welding techniques with 2319 filler metal. Weldments were produced in a single pass at 8.75 ki lojoules per inch (kJ/in.) for a Va-in. thick plate and 84 kJ/ in. for a Vz-in. thick plate, and in a double pass at 42 kJ/ in. for a Vz-in. thick plate. Cooling rates and dendrite arm spacings were measured and plotted versus heat input or solidification parameter, (Q/V)' . Agreement is good with previous investigations. Solution kinetics of the interdendritic nonequil ibrium phase were established and tensile properties were measured in the as-welded and solutionized conditions. With decreasing heat input dendrites become finer, the amount of inTable 1 — Chemical Analysis and Mechanical Properties of 2014 Aluminum Alloy Plate and 2319 Filler Metal Chemical composit ion Material Mn Cr Ti Al Fe Cu 0.048 in. 2319 filler 0.32 0.20 metal 0.15 Bal. Mechanical properties Test U.T. S. , Material direction psi V4 in. 2014 Longitudinal 70.200 alloy plate (a) Transverse 71.900 Vt in. 2014 Longitudinal 71.500 alloy sheet Transverse 70.900 Mg Zn V4 in. 2014 alloy plate 0.81 0.92 0.05 0.03 Bal. 0.48 4.10 0.59 0.23 VA in. 2014 alloy plate 0.77 0.92 0.06 0.02 Bal. 0.49 4.14 0.69 0.16
The Combined Effect of Air Leakage and Conductive Heat Transfer in Window Frames and Its Impact on the Canadian. Energy Rating Procedure

This paper examines the interaction between air infil­ tration/exfiltration and conductive heat transfer in window frames. This two-dimensional conjugate heat transfer prob­ lem is solved numerically using a finite-volume method. Two window frame geometries are examined with representative infiltration air leakage rates of 1.65 and 0.55 m3/h per meter of crack length (0.3 and 0.1 Flmin per foot of crack). For each geometry, an aluminum frame with a PVC thermal break and a PVC frame are considered. For the air infiltration case, the air-frame interaction causes the air to be preheated by the frame and decreases the apparent thermal transmittance of the frame. Conversely, air exfiltration increases the frame temperature, which increases heat losses, and the apparent thermal trans­ mittance of the frame. When it is assumed that half the windows experience infiltration and the other half exfiltra­ tion, results indicate that the value of ER, calculated with a proper account of the air leakage-frame interaction, could be approximately 4.0 W! m2( 1.3 Btu! hfr) higher than the ER value calculated using the current CSA procedure (CSA 1993).
Gradient-based guidance for controlling performance in early design exploration

In recent years, heuristic optimization techniques have become widely used in architectural and structural design practice. However, when used as a black box solver rather than an interactive design tool, such strategies become essentially passive, ceding considerable design control to the computer. Although researchers have developed interactive versions of common approaches such as evolutionary algorithms, there has been less focus on finding ways to use gradient-based optimization techniques in cases where designers seek increased creative control. This paper explores two ways in which gradient-based guidance can be exploited as part of an interactive design process: live gradient vector visualization for geometric design problems, and taking discrete steps in the design space based on performance information. These strategies are first demonstrated on a simple truss, before being tested on parametric models for a courtyard building and a long-span airport terminal. Initial results show that with further work, gradient-based guidance during interactive design exploration could be a viable strategy for designers seeking more control than is allowed by automated optimization algorithms.
SENSIBILITY ANALYSIS OF POLITICIANS' WEB LANGUAGE BY QUANTITATIVE LINGUISTICS

In politics, the sensibility words play an important role to move citizen's feelings with a brief slogan. The purpose of this paper is to examine the characteristics of the political affection by the feature of the sensibility words. The sensibility words have been extracted from the Web pages of Diet member of the Liberal-Democratic Party, the Democratic Party, the Communist Party, and the Social Democratic Party in Japan. The extracted sensibility words were classified and examined. It was clarified that Japanese politicians have some common characteristics about sensibility expressions irrelevant to their ideologies. Moreover, it is possible to analyze the nuance of a political slogan by utilizing the database of the words that has dependent relationships with obtained sensibility word.
Guidelines for Phasing Variants Using Bio-Rad’s Droplet Digital PCR System

Droplet Digital PCR We performed ddPCR as instructed by the manufacturer (Bio-Rad Laboratories), but used wide-bore pipet tips (Rainin) and gentle mixing to minimize DNA fragmentation. Introduction Droplet Digital PCR (ddPCR) enables absolute quantification of nucleic acid sequences by dividing reaction mixtures into nanoliter-sized droplets. Well-known applications for Droplet Digital PCR include sensitive rare mutation detection and accurate measurements of copy number variation (CNV). Here, we show that Droplet Digital PCR can also be used to determine which alleles are located on the same chromosome, a process known as phasing.
Factors Affecting Green Area Development And Managementfor Improving Sustainable Urban Environmentin The Case Of Debreberhantown,Ethiopia: Make Town Aesthetic With Greenery

Green area development and management have been used to improve environmental conditions, protect and improve biodiversity, promote outdoor activities and active lifestyles, increase social interaction and exchange, and provide healthy urban conditions for good physical and mental well-being. When designed well, urban green areas can be universally accessible, providing benefits for all members of the urban community. The main objective of this study was to assess factors that affect green area development and management in DebreBerhan town. The study is important to minimize challenges for green area management and development and it would be used as base for the further research and for policy makers.The study employed a cross-sectional mixed method design, which was a procedure for collecting, analyzing and mixing both quantitative and qualitative data at some stage of the research process. The study shows that there were some private associations who had developed their own greenareas, though the structural plan of the town did not clearly design green areas compoundsgovernment institutions and individuals. There were various factors for the lowdevelopment of the sector in the town. Lack of finance, lack of awareness, low level of the community participation with municipality in green area development, and lack of professionals were the major challenges for the development of green areas.The paper concluded some basic issues to alleviate the challenges and make the town ascompetitive and sustainable as other cities in Ethiopia. Professional training, awarenesscreation through different means and integration with stakeholders to increaseparticipations were some of the recommendations suggested by the paper. Moreover, thepaper strongly suggest that, town officials who had a mandate and responsibilitiesshould be equipped with the concept of sustainable town and creatingsustainable community through green area development.
Replicating Hong Kong

This study addresses the viability of Paul Romer's charter cities idea as an economic development strategy of developing countries. When the ides was proposed, Romer cited Hong Kong as the most successful case of charter city. Based on the theoretical framework developed from institutional theories of economic growth and institutional changes, we assess the viability of charter city idea and the soundness of the economic performance of Hong Kong. The case study reveals that the charter city idea is, indeed, a brilliant one which can bring economic prosperity to developing countries in early stage of development. But, it, as is asserted elsewhere, is not politically correct guide to economic development. The case of Hong Kong confirms this assertion by revealing that the exclusion of politics which has been key factors for Hong Kong’s economic success is now become the serious bottleneck for further development of the country.
Organizational and Corporate Identity on Social Media: A Literature Review

Social media have created a multitude of ways for organizations to develop and disseminate their corporate and organizational identity. However, little is still known about how identity can be observed on social media. To address this research gap, we conducted a scoping review that collected, analyzed and synthesized the corpus of published research on organizational and corporate identity and social media. The analysis presented in this paper provides a description of the state-of-the-art on this topic that we hope can help future scholars to understand the various methodological approaches and types of data most pertinent to the exploration of organizational and corporate identity on social media, even though, overall, it reveals that there are relatively few studies with a reliable and universal method for measuring these concepts. This guarantees that future research will be necessary. Practitioners may also wish to draw on our findings to design more tailored ways of strengthening their organizational and corporate identity.
Changes in Choroidal Thickness after Hemodialysis and the Influence of Diabetes

Copyright © 2017 The Korean Retina Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 2508-1926 eISSN 2508-3589 Journal of Retina 2017;2(2):76-82 https://doi.org/10.21561/jor.2017. 2.2. 76