Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship of Active Galactic Nuclei & Quasars With Their Local Galaxy Environment

We explore how the local environment is related to properties of active galactic nuclei (AGNs) of various luminosities. Recent simulations and observations are converging on the view that the extreme luminosity of quasars, the brightest of AGNs, is fueled in major mergers of gas-rich galaxies. In such a picture, quasars, the highest luminosity AGNs, are expected to be located in regions with a higher density of galaxies on small scales where mergers are more likely to take place. However, in this picture, the activity observed in low-luminosity AGNs is due to secular processes that are less dependent on the local galaxy density. To test this hypothesis, we compare the local photometric galaxy density on kiloparsec scales around spectroscopic type I and type II quasars to the local density around lower-luminosity spectroscopic type I and type II AGNs. To minimize projection effects and evolution in the photometric galaxy sample we use to characterize AGN environments, we place our random control sample at the same redshift as our AGNs and impose a narrow redshift window around both the AGNs and control targets. Our results support these merger models for bright AGN origins. We find that the brightest sources have overdensities that increase on the smallest scales compared to dimmer sources. In addition, we investigate the nature of the quasar and AGN environments themselves and find that the increased overdensity of early-type galaxies in the environments of bright type I sources suggests that they are located in richer cluster environments than dim sources. We measure increased environment overdensity with increased quasar black hole mass, consistent with the well-known M_{DMH}-M_{BH} relationship, and find evidence for quenching in the environments of high accretion efficiency type I quasars.
A Proposal for a Three Detector Short-Baseline Neutrino Oscillation Program in the Fermilab Booster Neutrino Beam

A Short-Baseline Neutrino (SBN) physics program of three LAr-TPC detectors located along the Booster Neutrino Beam (BNB) at Fermilab is presented. This new SBN Program will deliver a rich and compelling physics opportunity, including the ability to resolve a class of experimental anomalies in neutrino physics and to perform the most sensitive search to date for sterile neutrinos at the eV mass-scale through both appearance and disappearance oscillation channels. Using data sets of 6.6e20 protons on target (P.O.T.) in the LAr1-ND and ICARUS T600 detectors plus 13.2e20 P.O. T. in the MicroBooNE detector, we estimate that a search for muon neutrino to electron neutrino appearance can be performed with ~5 sigma sensitivity for the LSND allowed (99% C.L.) parameter region. In this proposal for the SBN Program, we describe the physics analysis, the conceptual design of the LAr1-ND detector, the design and refurbishment of the T600 detector, the necessary infrastructure required to execute the program, and a possible reconfiguration of the BNB target and horn system to improve its performance for oscillation searches.
Cardiac Excitation and Contraction Kv (cid:2) 1.1 (AKR6A8) senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity

1.1 senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity. The present study investigates the physiological role of Kv (cid:2) 1 subunit for sensing pyridine nucleotide (NADH/NAD (cid:3) ) changes in the heart. We used Kv (cid:2) 1.1 knockout (KO) or wild-type (WT) mice and established that Kv (cid:2) 1.1 preferentially binds with Kv4.2 and senses the pyridine nucleotide changes in the heart. The cellular action potential duration (APD) obtained from WT cardiomyocytes showed longer APDs with lactate perfusion, which increases intracellular NADH levels, while the APDs remained unaltered in the Kv (cid:2) 1.1 KO. Ex vivo monophasic action potentials showed a similar response, in which the APDs were prolonged in WT mouse hearts with lactate perfusion; however, the Kv (cid:2) 1.1 KO mouse hearts did not show APD changes upon lactate perfusion. COS-7 cells coexpressing Kv4.2 and Kv (cid:2) 1.1 were used for whole cell patch-clamp recordings to evaluate changes caused by NADH (lactate). These data reveal that Kv (cid:2) 1.1 is required in the mediated inactivation of Kv4.2 currents, when NADH (lactate) levels are increased. In vivo, isoproterenol infusion led to increased NADH in the heart along with QTc prolongation in wild-type mice; regardless of the approach, our data show that Kv (cid:2) 1.1 recognizes NADH changes and modulates Kv4.2 currents affecting AP and QTc durations. Overall, this study uses multiple levels of investigation, including the heterologous overexpression system, cardiomyocyte, ex vivo, and ECG, and clearly depicts that Kv (cid:2) 1.1 is an obligatory sensor of NADH/NAD changes in vivo, with a physiological role in the heart. NEW & NOTEWORTHY Cardiac electrical activity is mediated by ion channels, and Kv4.2 plays a signiﬁcant role, along with its binding partner, the Kv (cid:2) 1.1 subunit. In the present study, we identify Kv (cid:2) 1.1 as a sensor of pyridine nucleotide changes and as a modulator of Kv4.2 gating, action potential duration, and ECG in the mouse heart. control. Western blot analysis. Protein extracts from left ventricle (LV) of KO and WT mice hearts were isolated and quantiﬁed as described
MPT-MAC: A Multiple Packets Transmission MAC Protocol for Wireless Sensor Networks

—Event detection is a major application in wire- less sensor networks (WSNs). Current Medium Access Control (MAC) protocols for WSNs are mainly optimized for the situation that an event generates only one data packet on a single node and the event occurrence rate is low. When an event generates multiple data packets or the event occurrence rate is relatively high, packet delivery latency and delivery ratio are degraded rapidly. In this paper, we present a new MAC protocol called Multiple Packets Transmission MAC (MPT-MAC) for event-based WSNs. MPT-MAC schedules multiple data packets generated by an event on a single node to be forwarded over multiple hops in an operational cycle. By this means, MPT-MAC can achieve low delivery latency and high delivery ratio under heavy trafﬁc loads. We use event delivery latency (EDL) and event delivery ratio (EDR) to measure the event detection capability of MPT-MAC protocol. We show the performance of MPT-MAC through detailed ns-2 simulation. Compared to S-MAC-AL, R- MAC and DW-MAC, MPT-MAC can achieve lower EDL and higher EDR without more energy consumption. Furthermore, MPT-MAC can obtain lower duty cycle than DW-MAC when satisfying the latency requirement of the applications.
Percutaneous Coronary Intervention Early Stent Thrombosis after Percutaneous Coronary Intervention for Acute Myocardial Infarction

Stent thrombosis (ST) is the most feared complication of coronary stent treatment because of its morbidity and mortality. Ongoing research is focusing on the frequency and the timing in various patient subsets as well as the factors associated with the occurrence of ST. The mechanism of ST is multifactorial, hence various procedure-, lesion- and patient-related factors have been associated with its occurrence. Beside these factors the role of adjunctive antithrombotic therapy remains unchallenged. Emerging data suggest that primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) can be a predictor of subsequent ST. As patients presenting with STEMI are at increased risk of ST, employment of the optimal pharmacological, procedure- and device-related prevention and treatment modalities are imperative.
Global Diabetes open access Journal Low-glycemic Index Diets in the Improvement of HbA1c in Diabetes: A Systematic Review of Randomized Control Trials

There is a controversy around the world about the utility of low-GI diets in diabetes management. The aim of this systematic review is to assess the effect of low-GI diets in the improvement of Hemoglobin A1c (HbA1c) in diabetes in randomized control trials. Literature searches identified 10 Randomized Control Trials (RCT) comprising 630 subjects, that met strict inclusion criteria. All were randomized crossover or parallel experimental design with a diet duration ranging from 4 to 48 weeks. There was a significant difference in HbA1c levels between the low-GI and the high-GI diets in 6 out of 10 studies. Low-GI diets may contribute to improved glycemic control in diabetes, but further research is required to determine the benefit on long-term glycemic control.
Fast neutron spectrum unfolding for nuclear nonproliferation and safeguards applications

We present new neutron spectrum unfolding results obtained from measurements with Cf-252 and plutonium-oxide sources. The precise knowledge of the neutron energy spectrum provides information about the presence or absence of fissile material and about the characteristics of the material. We used a neutron spectrum unfolding technique based on a modification of the least-squares method. The main innovation is the use of a Krylov subspace iteration which performs better on ill-conditioned systems of linear equations than standard direct-solution methods. The proposed technique performed well in the unfolding of measured neutron pulseheight distributions from a Cf-252 neutron source and from plutonium-oxide samples and could be easily implemented in a portable neutron spectroscopy system for nuclear nonproliferation and safeguard applications.
Compensatory changes in CYP expression in three different mouse models: CAR-null, Cyp3a-null, and mice.

Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individu-als. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes in transcript levels, protein expression, and steroid hydroxylation of several xenobiotic detoxifying CYPs in constitutive androstane receptor (CAR)-null and two CYP-null mouse models that have subfamily members regulated by CAR; the Cyp3a-null and a newly described Cyp2b9/10/13-null mouse model. Compensatory changes in CYP expression that occur in these models may also occur in polymorphic humans, or may complicate interpretation of ADME studies performed using these models. The loss of CAR causes significant changes in several CYPs probably due to loss of CAR-mediated constitutive regulation of these CYPs. Expression and activity changes include significant repression of Cyp2a and Cyp2b members with corresponding drops in 6 α - and 16 β -testosterone hydroxylase activity. Further, the ratio of 6 α -/15 α -hydroxylase activity, a biomarker of sexual dimorphism in the liver, indicates masculinization of female CAR-null mice, suggesting a
DETECTING SALIENT OBJECTS IN A VIDEO’S BY USING SPATIO-TEMPORAL SALIENCY & COLOUR MAP

When we watch a video, a detection of salient object is not a simple task, because in background many other processes are performed. So for detection of salient object we design a novel method, which uses the particle filters. In this new approach, spatial temporal saliency map & colour feature are used this will quickly recover from false detection. Actually the proposed method is based on the local feature comparing with dominant feature present in the frame. Above method is a marked object of salient, where there is a large difference between local and dominant features. Here we have to use two types of saliency. First saliency method is a spatio saliency which uses hue & saturation feature and second method called as motion saliency which uses optical flow vector feature. So in the above proposed saliency technique the updation of motion Saliency & spatial saliency will be considered in an every iteration, so complexity of detection of salient object is reduced.
Force and Moment Calculations of an Appendage Using the Reynolds Averaged Navier-Stokes Equations.

Abstract : This report describes efforts to compute forces and moments about an appendage using the Reynolds averaged Navier-Stokes (RANS) equations. All computations presented are done with the Mississippi State University code UNCLE. Calculations are performed for a two-dimensional NACA 0012 airfoil and a three-dimensional NACA 0015 low-aspect ratio appendage mounted on a ground board. Results are presented for both forward and reverse flow conditions.
Edinburgh Research Explorer The histone lysine demethylase JMJD3/KDM6B Is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner

The JmjC domain-containing protein JMJD3/KDM6B catalyses the demethylation of H3K27me3 and H3K27me2. JMJD3 appears to be highly regulated at the transcriptional level and is upregulated in response to diverse stimuli such as differentiation inducers and stress signals. Accordingly, JMJD3 has been linked to the regulation of different biological processes such as differentiation of embryonic stem cells, inflammatory responses in macrophages, and induction of cellular senescence via regulation of the INK4A-ARF locus. Here we show here that JMJD3 interacts with the tumour suppressor protein p53. We find that the interaction is dependent on the p53 tetramerization domain. Following DNA damage, JMJD3 is transcriptionally upregulated and by performing genome-wide mapping of JMJD3, we demonstrate that it binds genes involved in basic cellular processes, as well as genes regulating cell cycle, response to stress and apoptosis. Moreover, we find that JMJD3 binding sites show significant overlap with p53 bound promoters and enhancer elements. The binding of JMJD3 to p53 target sites is increased in response to DNA damage, and we demonstrate that the recruitment of JMJD3 to these sites is dependent on p53 expression. Therefore, we propose a model in which JMJD3 is recruited to p53 responsive elements via its interaction with p53 and speculate that JMJD3 could act as a fail-safe mechanism to remove low levels of H3K27me3 and H3K27me2 to allow for efficient acetylation of H3K27. The Is Recruited to
Danube RiveR: seDimentological, mineRalogical anD geochemical chaRacteRistics of the bottom seDiments

activi-Abstract . For a better understanding of the recent pollution in the lower Romanian sector of the Danube and its relations with human activities, yearly investigations have been carried out on 50 cross sections, between km 1072 - Bazias and the Danube mouths, using R/V Istros . The field activity was performed on three main sections, each with different geological, morphological and hydrological features: Iron Gates I and II dam lakes, km 845 – Mile 44, and the Danube Delta area. Physical and chemical investigations were performed on bottom sediment and surface water samples. Biological samples were collected and investigated as well. The 2005 results allowed an assessment of the Danubian aquatic environment, the comparison of present and previously collected data and the identification of significantly sensitive areas. Mitigation strategies according to the EU requirements are proposed.
Molecular Cloning and High-Level Expression of a Bromoperoxidase Gene from Streptomyces aureofaciens Tut24

A bromoperoxidase gene was cloned from Streptomyces aureofaciens Tu24 into Streptomyces lividans TK64 by using the promoter-probe vector pIJ486. Subcloning of DNA from the original, unstable clone allowed the gene to be localized to a 1.7-kilobase (kb) fragment of DNA. Southern blotting showed that the cloned 1.7-kb insert hybridized to a 4.3-kb fragment in an SstI digest of S. aureofaciens Tu24 total DNA. The 1.7-kb insert was shown to code for a protein with the electrophoretic properties of the subunits of the nonheme bromoperoxidase isolated from S. aureofaciens Tu24. - The protein produced by S. lividans TK64 transformed with pHM621, which contained an 8.0-kb insert, was shown to be identical to the S. aureofaciens Tu24 bromoperoxidase in terms of its electrophoretic mobility on denaturing and nondenaturing polyacrylamide gels and its NH2-terminal amino acid sequence. The bromoperoxidase was overproduced (up to 180 times) by S. lividans TK64 containing pHM621. Based on the heat stability of the S. aureofaciens Tu24 bromoperoxidase, a new and simple purification procedure with very high yields was developed.
COMPARISON OF ADHERENCE AND PREVALENCE OF DEPRESSION AMONG HEPATITIS C INFECTED CIRRHOTIC AND NON-CIRRHOTIC PATIENTS TREATED WITH PEGYLATED INTERFERON PLUS RIBAVIRIN VERSUS DIRECT-ACTING ANTIVIRALS

to produce a ABSTRACT Background: Adherence of hepatitis C infected patients to combination therapy of pegylated interferon (PEG-IFN) and ribavirin (RBV) is often inadequate. The, new, all-oral, direct-acting antivirals (DAAs) are expected to exhibit a better adherence profile due to a less complex administration schedule and fewer side effects, including depression. Methods: One hundred and twenty patients with chronic hepatitis C were included in the study. Sixty patients received PEG-IFN plus RBV (Group A) while the remaining sixty patients were treated with DAAs (Group B). Comparison of adherence and prevalence of depression were carried out between the two groups. Additionally, subgroup comparison of adherence and prevalence of depression were conducted between 21 cirrhotic patients from group A and 25 patients with cirrhosis from group B. Patient adherence was estimated with the «A-14 scale» and the prevalence of depression with «Beck Depression Inventory». Results: Patients from group A were found to be less compliant, with higher rates of clinical depression compared to patients from group B (45/60 vs 57/60, p=0.0039 and 37/60 vs 13/60, p<0.0001 respectively). Similarly, HCV-infected cirrhotic patients receiving PEG-IFN and ribavirin were less adherent with higher prevalence of depression compared to HCV-infected cirrhotic patients treated with DAAs (14/21 vs 24/25, p=0.0161 and 15/21 vs 8/25, p=0.0169 respectively). Conclusion : Treatment with DAAs seems to be associated with higher adherence rates and lower rates of depression compared to IFN-based treatment (PEG-IFN plus RBV) in both cirrhotic and non-cirrhotic patients. Consequently, DAAs could help to improve treatment efficacy and quality of life.
Recommender Systems for Museums: Evaluation on a Real Dataset

—This paper discusses the evaluation of several recommendation methods used to suggest relevant contents to museum visitors. We employed traditional recommender systems along with our versatile Social Filtering formalism to test different strategies on a genuine dataset, which was collected during a recent cultural exhibition that received signiﬁcant interest in Paris, France. The results show the promising potential of recommendation techniques in the not so well explored application domain of museum visit. This work is part of the AMMICO on-going research project that aims to develop “smart” audio guides for museums.
Enhanced thermoelectric figure of merit of CoSb3 via large-defect scattering

We have measured the structural, chemical, and transport properties of a series of CoSb3 skutterudite samples modified by fullerene additions of 0, 0.52, 3.28, 3.90, 4.77, and 6.54 mass%. Fullerene is a 60-atom carbon molecule that forms microsize clusters between the grain boundaries of CoSb3. We observed that the dominant scattering mechanism in the electrical transport changes from impurity scattering to grain-boundary scattering near a C60 content of ∼5–6 mass%, and that thermal conductivity decreases with increasing C60 content. A significant increase in the thermoelectric figure of merit is achieved for 6.54 mass% C60 compared to the pure CoSb3.
ACUTE TOXICITY OF Β-KITIN EXTRACTED FROM THE SHELL OF BLUE SWIMMING CRAB (PORTUNUS

Objective: This work aimed to study the acute toxicity of β-chitin extracted from crab shells in Bal b/c mice. Method: The acute toxicity test was performed by following the OECD guidelines. Female mice were given single or divided doses of β-chitin (maximum 24 h) with doses of 500, 1000, 2000, 4000, and 6000 mg/kg of BW. Observations were made for 14 d, including behaviour, body weight, organ weight, and histopathology of vital organs (stomach, heart, liver, kidney, and lung). Results: During 14 d, no deaths and no abnormalities in behaviour, bodyweight or organ weight were observed. Qualitative histopathological observations at the highest dose showed abnormalities of the liver and kidney compared to those of the control group. Nevertheless, the abnormalities did not affect the organ function. Conclusion: This acute toxicity study reveals that β-chitin up to a dose of 6000 mg/kg of BW is not toxic, as proved by the normal behaviour, body weight, and vital organ weight of the animals. Further chronic toxicities study is needed to confirm its safety.
A unified thermal and vertical trajectory model for the prediction of high altitude balloon performance

A computer model for the prediction of the trajectory and thermal behavior of zero-pressure high altitude balloon was developed. In accord with flight data, the model permits radiative emission and absorption of the lifting gas and daytime gas temperatures above that of the balloon film. It also includes ballasting, venting, and valving. Predictions obtained with the model are compared with flight data from several flights and newly discovered features are discussed.
Economics of Education Detecting Academic Peer Effects: Exploring the Role of Time-use

It has been diﬃcult to ﬁnd evidence of academic peer eﬀects using the workhorse linear-in-means model. We use this model and data from the Berea Panel Study to examine academic peer eﬀects in college. In the short run, a student’s academic ability may be ﬁxed, but decisions about time-use may be inﬂuenced by peers. When we use a variable collected at the time of college entrance to directly measure students’ propensities to study do we ﬁnd that peers aﬀect one’s grades. Time diaries provide support of a mechanism wherein peer study propensity aﬀects achievement by increasing own study eﬀort.
Synthetic microProteins: versatile tools for post-translational regulation of target proteins

46 MicroProteins are small, single-domain proteins that regulate multi-domain proteins by 47 sequestering them into novel, often non-productive, complexes. Several microProteins 48 have been identified in plants and animals, most of which negatively regulate transcription 49 factors. MicroProtein candidates that potentially target a wide range of different protein 50 classes were recently identified in a computational approach. Here, we classified all 51 Arabidopsis thaliana microProteins and developed a synthetic microProtein approach to 52 target specific protein classes, such as hydrolases, receptors, and lyases in a proof-of- 53 concept approach. Our findings reveal that microProteins can be used to influence 54 different physiological processes, which makes them useful tools for post-translational 55 regulation in plants and potentially also in animals. candidates, may regulate transcription factors, all currently known 128 microProteins. The remaining 27 % microProtein candidates and their putative 129 targets known biological activity known protein–protein interaction domains. These 130 323 potential microProteins were grouped into the 19 remaining parental classes and 131 analyzed in relation to the total amount of proteins in the respective protein class The microProtein candidates of the hydrolase, nucleic acid binding, chaperone, 133 transfer/carrier protein, and cell adhesion molecule protein classes were significantly over- 134 represented compared to the total amount of proteins. These findings indicate that 135 microProteins might be involved in the regulation of a wide range of protein classes. Many 136 microProteins are part of a family with two or more microProteins, such as the ZPR 137 microProteins. Bioinformatic analyses revealed that most microProtein candidates are part