Miracle-dz/UniFAR-FTUs huggingface dataset:
DWMAcc

PIM (processing-in-memory) based hardware accelerators have shown great potentials in addressing the computation and memory access intensity of modern CNNs (convolutional neural networks). While adopting NVM (non-volatile memory) helps to further mitigate the storage and energy consumption overhead, adopting quantization, e.g., shift-based quantization, helps to tradeoff the computation overhead and the accuracy loss, integrating both NVM and quantization in hardware accelerators leads to sub-optimal acceleration. In this paper, we exploit the natural shift property of DWM (domain wall memory) to devise DWMAcc, a DWM-based accelerator with asymmetrical storage of weight and input data, to speed up the inference phase of shift-based CNNs. DWMAcc supports flexible shift operations to enable fast processing with low performance and area overhead. We then optimize it with zero-sharing, input-reuse, and weight-share schemes. Our experimental results show that, on average, DWMAcc achieves 16.6× performance improvement and 85.6× energy consumption reduction over a state-of-the-art SRAM based design.
The Impact of Online Branding and E-Service Quality on Fan Trust and Loyalty: A Case of Thai Soccer Club

Digital marketing has gained popularity among the professional sport organisations. The team-sport clubs nowadays have their own online channel to enhance fan trust and loyalty. Despite the large investment in time and resources to drive online branding, research devoted to sport-fan engagement on online channel is still very limited. Thus, this study examines the influence of online channel on brand, e-service quality and image of Thai soccer clubs. A total of 500 questionnaires were collected from a group of soccer fan club of SCG Muangthong United. The respondents had regularly visited the club's website with in a period of consecutive three months; to either get information or watch the football matches online. The findings revealed the positive relationship between brand involvement, brand attitude, e-service quality and online trust of which turned into customer loyalty. Nonetheless, the website image was found to have no congruence influence on online trust in the case of SCG Muangthong United.
Cardiolipin Preferentially Partitions to the Inner Leaflet of Mixed Lipid Large Unilamellar Vesicles.

Cardiolipin (CL), an anionic phospholipid constituting 20% of the inner mitochondrial membrane (IMM) of eukaryotes, stabilizes electron transport chain (ETC) complexes and is a signaling agent in the early stages of apoptosis. For apoptosis, CL moves from the inner to the outer leaflet of the IMM via a poorly understood mechanism. Relative to cylindrically-shaped lipids like dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylglycerol (DOPG), cone-shaped CL should prefer concave surfaces of lipid bilayers. Using the fluorophore, 1,1,2,2,-tetrakis[4-(2-trimethylammonioethoxy)phenyl]ethene, we have measured CL versus DOPG partitioning to the inner versus the outer leaflet of liposomes in mixed lipid systems with DOPC. DOPG shows no leaflet preference. However, CL has a 4:1 preference for the concave surface of the inner leaflet of liposomes. To further test the inner leaflet preference of CL, we show that cytochrome c binding to the outer convex surface of 20% CL/80% DOPC vesicles is strongly attenuated. Because the outer leaflet of intra-cristal regions of the IMM has concave curvature, the preference of CL for concave surfaces may facilitate the transport of CL from the inner to the outer leaflet of the IMM needed for CL remodeling, the optimal functioning of the ETC and signaling in the early stages of apoptosis.
HLA Polymorphism in Regressive and Non‐Regressive Autism: A Preliminary Study

Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%–30% of affected cases experience a loss of language and social skills around 18–30 months, so‐called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM‐IV TR criteria, with and without regression. We found that 62 of the 98 non‐regressive ASD patients carry the HLA‐DPA1*01‐DPB1*04 sub‐haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA‐DPA1*01‐DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182–186. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc.
Chronic kidney disease and coronary atherosclerosis: evidences from intravascular imaging

ABSTRACT Introduction: In CKD subjects, atherosclerotic cardiovascular disease (ASCVD) is a major cause of their morbidity and mortality (1–3). Current therapeutic guidelines recommend lowering LDL-C level to prevent ASCVD (4, 5). However, it remains uncertain how this therapeutic approach effectively modifies atherosclerosis of CKD. These findings suggest the need to further understand pathophysiology of atherosclerosis. Given that intravascular imaging modalities have contributed to characterize the natural history of coronary atherosclerosis (13–23), the integration of plaque imaging is expected to help to elucidate targets associated with stabilizing atheroma. Areas covered: This review will outline atherogenic stimuli in patients with CKD. In addition, the characteristics of their coronary atheroma will be presented from finding in clinical studies using a variety of intravascular imaging modalities. The efficacy of current guideline recommended anti-atherosclerotic therapies in CKD patients will be also summarized. All related articles were searched through PubMed. Expert opinion: Integration of intravascular imaging has a great potential to establish effective therapies for slowing progression of atherosclerosis in subjects with CKD. More efforts toward searching therapeutic target associated with atherosclerosis of CKD are required. In particular, identifying drivers associated with plaque calcification will lead to the development of new agents which regress calcium accumulation.
Liquid Anaerobic Digestate as a Source of Nutrients for Lipid and Fatty Acid Accumulation by Auxenochlorella Protothecoides

In recent years, there has been growing interest in the biomass of unicellular algae as a source of valuable metabolites. The main limitations in the commercial application of microbial biomass are associated with the costs of production thereof. Maize silage is one of the main substrates used in biogas plants in Europe. The effects of sterilized agricultural liquid digestate (LD) from methane fermentation of maize silage on the growth rates, macro and micronutrient removal efficiency, lipid content, and fatty acid profile in Auxenochlorella protothecoides were investigated. The results indicate that A. prothecoides can proliferate and accumulate lipids with simultaneous reduction of nutrients in the 1:20 diluted liquid digestate. The rate of nitrogen and phosphorus removal from the liquid digestate was 79.45% and 78.4%, respectively. Cells growing in diluted liquid digestate exhibited the maximum lipid content, i.e., 44.65%. The fatty acid profile of A. prothecoides shows a decrease in the content of linolenic acid by 20.87% and an increase in oleic acid by 32.16% in the LD, compared with the control. The liquid digestate changed the content of monounsaturated fatty acids and polyunsaturated fatty acids. The cells of A. protothecoides growing in the liquid digestate were characterized by lower PUFA content and higher MUFA levels.
Changes in Weight and Substrate Oxidation in Overweight Adults Following Isomaltulose Intake During a 12-Week Weight Loss Intervention: A Randomized, Double-Blind, Controlled Trial

Low-glycemic compared to high-glycemic diets have been shown to improve metabolic status and enhance fat oxidation. The randomized, double-blind, controlled intervention study aimed to evaluate the effects of an energy-reduced diet containing isomaltulose (ISO, Palatinose™) versus sucrose (SUC) on body weight loss. Sixty-four healthy overweight/obese adults were allocated to consume either 40 g/day ISO or SUC added to an energy-reduced diet for 12 weeks. Anthropometric measurements, body composition, and energy metabolism were assessed at baseline and after 4, 8, and 12 weeks. Fifty participants (age: 40.7 ± 11.7 y; BMI: 29.4 ± 2.7 kg/m²) completed the study. During the 12 weeks, both groups significantly lost weight (p < 0.001), which was more pronounced following ISO (−3.2 ± 2.9 vs. −2.1 ± 2.6 kg; p = 0.258). Moreover, for participants in the ISO group, this was accompanied by a significant reduction in fat mass (ISO: −1.9 ± 2.5, p = 0.005; SUC: −0.9 ± 2.6%, p = 0.224). The overall decrease in energy intake was significantly higher in the ISO compared to that in the SUC group (p = 0.022). In addition, breakfast containing ISO induced a significantly lower increase in postprandial respiratory quotient (RQ) (mean incremental area under the curve (iAUC)2h for ISO vs. SUC: 4.8 ± 4.1 vs. 6.9 ± 3.1, p = 0.047). The results suggest that ISO in exchange for SUC may help to facilitate body weight reduction, lower postprandial RQ associated with higher fat oxidation, and reduce energy intake.
Obesity and 25(OH)D Serum Concentration Are More Important than Vitamin D Intake for Changes in Nutritional Status Indicators: A Population-Based Longitudinal Study in a State Capital City in Southern Brazil

Our objective was to investigate the relationship between dietary vitamin D intake and serum concentration of vitamin D (25(OH)D) on changes in body weight, waist circumference (WC), and body mass index (BMI), and to determine if this relationship changes between obese and non-obese individuals at baseline and those who have or do not have 25(OH)D deficiency. This was a prospective study with a sample of 572 individuals aged 25–65 years, who were participants in the cohort study EpiFloripa Adults. Changes in weight (in kg), BMI, and WC between 2012 and 2014 were evaluated as outcomes. The main exposure was the dietary intake of vitamin D (2012), and the 25(OH)D serum concentration was secondary. When the analyses were stratified by the presence of obesity in the baseline, among obese individuals it was observed that those in the extreme categories of vitamin D intake had an average gain of 3.0 kg in weight, 0.9 kg/m2 in BMI, and 1.7–2.7 cm in WC. When 25(OH)D serum concentration were incorporated into the analyses, it was observed that non-obese subjects not having 25(OH)D deficiency had a mean reduction of 2.3 cm in WC. In conclusion, the increases in body weight, BMI, and WC were higher over time in obese patients with deficient 25(OH)D serum concentration, regardless of dietary vitamin D intake.
The Effect of Bone Marrow Aspirate Concentrate Application on Distracted Bone Biomechanical Properties.

BACKGROUND This study was conducted to assess effect of bone marrow aspirate concentrate (BMAC) on enhancing biomechanical properties of distraction osteogenesis (DO). METHODS Twelve rami of goats had distraction and were divided into test group (DO bone supplemented with BMAC) and control group. RESULTS Assessment of bone-width showed nonsignificant (P = 0.9) increase in test group (mean = 5.3 mm, standard deviation = 1.9 mm) compared to control group (mean = 5.2 mm, standard deviation = 0.8 mm). Assessment of radiographic density showed nonsignificant (P = 0.5) increase in test group (mean = 163.4 Hounsfield Unit, standard deviation = 6.5 Hounsfield Unit) compared to control group (mean = 156.6 Hounsfield Unit, standard deviation = 21.8 Hounsfield Unit). Histomorphometry of mature-bone % showed significant (P = 0.02) increase in test group (mean = 30%, standard deviation = 9.8%) compared to control group (mean = 15.9%, standard deviation = 7.2%). Assessment of biomechanical testing (bone strength) by 3-point bending test showed nonsignificant (P = 0.7) increase in test group (mean = 511.6 Newton, standard deviation = 189.1 Newton) compared to control group (mean = 467.8 Newton, standard deviation = 201.1 Newton). CONCLUSION The BMAC failed to improve both bone quantity and biomechanical bone strength of distracted bone.
Remifentanil for abdominal surgery is associated unexpectedly unfavorable outcomes.

Insufficient perioperative pain treatment is known as a highly predictive risk factor for the development of chronic postoperative pain. Remifentanil is an ultrashort-acting opioid that provides quick and efficient analgesia but is associated with the induction of opioid-induced hyperalgesia. Despite these well-known characteristics, this substance is being increasingly used in anesthesia and in a variety of medical fields, such as intensive-care medicine and obstetrics.The aim of our study was to reveal whether remifentanil influences postoperative pain, the requirement for postoperative analgesics, and requirement of antiemetics (as indirect indicator of postoperative nausea and vomiting (PONV), as well as the effects on time to extubation and length of stay in the postanesthesia care-unit (PACU) in daily clinical routine.From an electronic medical records database of 55,693 anesthesias, we analyzed data from all patients receiving intraabdominal surgery (visceral, gynecological and urological) under general anesthesia or combined general-epidural anesthesia by propensity score matching.The administration of remifentanil was associated with higher postoperative pain scores despite a higher requirement of postoperative analgesics. Additional epidural analgesia was not able to avoid this finding.The intraoperative use of remifentanil is associated with a deterioration of pain levels and postoperative analgesic requirement, wherefore the potential benefit of this substance seems to be outweighed by its potential disadvantages. Especially in operative procedures in which high postoperative pain scores are expected, the unreflective use should be critically questioned.
Statistically Designed Medium Reveals Interactions between Metabolism and Genetic Information Processing for Production of Stable Human Serum Albumin in Pichia pastoris

Human serum albumin (HSA), sourced from human serum, has been an important therapeutic protein for several decades. Pichia pastoris is strongly considered as an expression platform, but proteolytic degradation of recombinant HSA in the culture filtrate remains a major bottleneck for use of this system. In this study, we have reported the development of a medium that minimized proteolytic degradation across different copy number constructs. A synthetic codon-optimized copy of HSA was cloned downstream of α–factor secretory signal sequence and expressed in P. pastoris under the control of Alcohol oxidase 1 promoter. A two-copy expression cassette was also prepared. Culture conditions and medium components were identified and optimized using statistical tools to develop a medium that supported stable production of HSA. Comparative analysis of transcriptome data obtained by cultivation on optimized and unoptimized medium indicated upregulation of genes involved in methanol metabolism, alternate nitrogen assimilation, and DNA transcription, whereas enzymes of translation and secretion were downregulated. Several new genes were identified that could serve as possible targets for strain engineering of this yeast.
The olfactory coreceptor IR8a governs larval feces-mediated competition avoidance in a hawkmoth

Significance Finding a suitable oviposition site is a challenging task for a gravid female moth. At the same time, it is of paramount importance considering the limited capability of most caterpillars to relocate to alternative host plants. The hawkmoth, Manduca sexta, oviposits on solanaceous plants. Larvae hatching on a plant that is already attacked by conspecific caterpillars face food competition. Here, we show that feces from conspecific caterpillars are sufficient to deter a female M. sexta from ovipositing on a plant. Furthermore, we not only identify the responsible compound in the feces but also localize the population of sensory neurons that governs the female’s avoidance. Hence, our work increases the understanding of how animals cope with a competitive environment. Finding a suitable oviposition site is a challenging task for a gravid female moth. At the same time, it is of paramount importance considering the limited capability of most caterpillars to relocate to alternative host plants. The hawkmoth, Manduca sexta (Sphingidae), oviposits on solanaceous plants. Larvae hatching on a plant that is already attacked by conspecific caterpillars can face food competition, as well as an increased exposure to predators and induced plant defenses. Here, we show that feces from conspecific caterpillars are sufficient to deter a female M. sexta from ovipositing on a plant and that this deterrence is based on the feces-emitted carboxylic acids 3-methylpentanoic acid and hexanoic acid. Using a combination of genome editing (CRISPR-Cas9), electrophysiological recordings, calcium imaging, and behavioral analyses, we demonstrate that ionotropic receptor 8a (IR8a) is essential for acid-mediated feces avoidance in ovipositing hawkmoths.
A review of heat transfer models of nanoporous silica aerogel insulation material

In this paper, the development of effective thermal conductivity models for nanoporous silica aerogel insulation materials is summarized. In the first part, heat transfer characteristics of nanoscale gaseous/solid/radiative heat transfer inside aerogel insulation material are introduced. Then, the existing theoretical models, empirical models, and numerical methods for the thermal conductivity of each heat transfer mode are reviewed and analyzed. After that, the advances in effective thermal conductivity models for the nanoporous silica aerogel materials as well as their composite insulation materials after the addition of opacifiers and reinforced fibers are presented. Next, the authors previous work is taken as an illustration of a procedure for establishing an effective thermal conductivity model of an aerogel insulation material from nano- to macro-scale. A brief introduction to the application of molecular dynamics in the simulation of aerogel materials is also given. In the end, further researchneeds are indicatedfor the nanoporous silica aerogel insulation materials. These include: the coupled heat transfer behavior at the gas–solid contact interface, the influence of scale/interfacial effects on the thermal conductivity of nanoscale solid particles, and the effect of different influencing factors on the total heat transfer performance. Such studies could provide help in accurately predicting the thermal conductivity as well as optimizing the insulation performance for the aerogel material and could provide guide for the design of new type aerogel insulation material which can be used in industry such as aeronautics and astronautics, thermal insulation, building, chemical industry and so on.
Development and evaluation of a questionnaire instrument for chemical intolerance, based on the International Classification of Functioning, Disability and Health

Abstract Purpose The purpose was to develop a questionnaire instrument to measure difficulties in activities and participation, and impact of environmental factors in chemical intolerance, based on the International Classification of Functioning, Disability and Health, and to assess its validity and reliability. Method Development in three steps: (1) choosing items of relevance for chemical intolerance with an expert group, (2) conducting interviews with persons with chemical intolerance, using sampling to redundancy, (3) conducting a survey with 112 respondents at a first assessment and 91 at a second assessment for test-retest. Results The final version of the instrument consists of 57 items divided in three parts, which showed good internal consistency in each part, Cronbach alpha: 0.73–0.87. It had good content validity, readability and face validity. Test-retest showed good to very good (≥0.61) Kappa agreement for 37 items, and moderate (0.41–0.60) for 17 items. Three items had poor or fair (<0.41) Kappa agreement. Conclusion The instrument was found to be valid and reliable. It can be used as a clinical tool to help persons with chemical intolerance to receive the best suited help and support for each individual, identify key points in rehabilitation, measure rehabilitation outcome and establish priority for treatment. IMPLICATIONS FOR REHABILITATION The questionnaire instrument based on the International Classification of Functioning, Disability and Health which was developed and evaluated in this study, can be used to measure difficulties in activities and participation, and impact of environmental factors in chemical intolerance. Persons with chemical intolerance report lack of support from healthcare and society. Using this questionnaire instrument can help forming the best suited help and support for each individual based on his/her preconditions. This questionnaire instrument can be used to identify key points in rehabilitation and measure rehabilitation outcome.
A water-soluble nanoconjugate for enhanced cellular delivery of receptor-targeted MR contrast agents.

ProGlo is an efficient steroid receptor-targeted magnetic resonance (MR) imaging contrast agent (CA). It has been shown to accumulate and produce enhanced image contrast in PR-positive cells and tissues in vitro and in vivo. However, the hydrophobicity of the steroid targeting domain of ProGlo (logP = 1.4) limits its formulation and delivery at clinically relevant doses. In this work, a hydrophobic moiety was utilized to drive efficient adsorption onto (nanodiamond) ND clusters to form a water-soluble nanoconstruct (logP = -2.4) with 80% release in 8 hours under biological conditions. In cell culture, the ND-ProGlo construct delivered increased concentrations of ProGlo to target cells compared to ProGlo alone. Importantly, these results were accomplished without the use of solvents such as DMSO, providing a significant advance toward formulating ProGlo for translational applications. Biodistribution studies confirm the delivery of ProGlo to PR(+) tissues with enhanced efficacy over untargeted controls. These results demonstrate the potential for a non-covalent ND-CA construct as a general strategy for solubilizing and delivering hydrophobic targeted MR CAs.