Miracle-dz/UniFAR-FTUs huggingface dataset:
COPD_A_338851 3449..3464

1Asthma Research Group Windsor-Essex County Inc., Windsor, ON, Canada; 2London School of Hygiene and Tropical Medicine, London, UK; 3Hotel-Dieu Grace Healthcare, Windsor, ON, Canada; 4London Health Sciences Centre, London, ON, Canada; 5Lawson Health Research Institute, London, ON, Canada; 6Schulich School of Medicine and Dentistry, Western University, London, ON, Canada Purpose: Integrated disease management (IDM) for COPD in primary care has been primarily investigated under clinical trial conditions. We previously published a randomized controlled trial (RCT) where the IDM intervention improved quality of life (QoL) and exacerbation-related outcomes. In this study, we assess the same IDM intervention in a real-world evaluation and identify patient characteristics associated with improved outcomes. Methods: This historical cohort study included patients enrolled for 12 (±3 months) in the Best Care COPD IDM program. The main outcome was a ≥3 point improvement in COPD assessment test (CAT). Secondary outcomes were COPD exacerbations requiring antibiotics and/or prednisone, unscheduled physician visits, emergency department visits and hospitalizations. Results: Data for 571 patients (all patients) were included, 158 met the reference RCT eligibility (RCT matched). Improved QoL was observed in 43% (95% CI:38.9,47.2) of all patients, 47% (95% CI:39.5,55.6) of RCT matched vs 92% (95% CI:79.2,95.1) in the reference RCT intervention arm (n=72). Reductions (12 months IDM vs prior year) were observed in the proportion of patients experiencing exacerbation-related events (all patients): antibiotics/prednisone (−9.0%,95% CI:13.9,-3.9); unscheduled physician (−33.1%,95% CI:-38.2,-27.9); emergency department (−9.6%,95% CI:-13.5,-5); and hospitalizations (−6.8%,95% CI:-10.0,-3.7). For the RCT matched group all reductions were comparable to the reference RCT intervention arm. The strongest predictors of improved QoL were baseline CAT, CAT≥20 vs CAT<10 (OR 15.6,95% CI:7.91,30.83), GOLD group B (OR 6.4,95% CI:3.42,11.85) and D (OR 5.64,95% CI:2.80,11.37) vs GOLD group A. Patients with prior antibiotic/prednisone use, FEV1 <30% predicted and GOLD group D were less likely to have no urgent health service utilization (OR 0.5,95% CI:0.30,0.68), (OR 0.2,95% CI:0.07,0.78) and (OR 0.3,95% CI:0.14,0.51), respectively. Conclusion: Best Care COPD improved QoL and reduced exacerbation-related outcomes in a manner directionally similar to the RCT from which it emanated. Baseline QoL, exacerbation history, and GOLD category were identified as possible predictors of IDM impact and will inform future program development and resource allocation.
Explaining News Trust in Social Media News during the COVID-19 Pandemic—The Role of a Need for Cognition and News Engagement

During the recent COVID-19 pandemic, people have, in many cases, acquired information primarily from social media. Users’ need to stay informed and the intensive circulation of news has led to the spread of misinformation. As they have engaged in news, it has raised the question of trust. This study provides a model on how news trust can be explained through a need for cognition and news engagement. Accordingly, 433 Slovenian social media users participated in our survey. Structural equation modeling revealed that (1) the lower the need for cognition and the more prior knowledge about COVID-19 users have, the more they believe that social media news comprises all facts about the disease; (2) the more users believe that news comprises all essential facts, the more they trust that the news depicts the actual situation about COVID-19 accurately; (3) the more users are interested in engaging with social media news, the more they trust that the actual situation about COVID-19 is depicted accurately. These findings may help authorities to frame messages about COVID-19 effectively. We suggest investing more effort in disseminating new scientific evidence about the disease to contribute to the accurate shaping of knowledge about COVID-19 among social media users.
A product design framework for a circular economy

The paper provides a circular economy framework from a product design perspective with tools to aid product designers in applying circular product design in practice. Design research for circular economy has so far mainly been limited to referring to existing fields of research such as design for disassembly, remanufacturing and recycling. The implications of combining these fields in the context of circular economy from a product design perspective however have remained largely unexplored. Furthermore, available aids for product designers are limited. A critical review of current ‘circular economy’ terminology led to the (re)definition the five most design-relevant topics: future proof design, and design for disassembly, maintenance, remake and recycling. With this an adapted circular economy model was proposed. Next, several tools were developed to aid a designer with the application of circular product design. The tools were tested and validated with Philips designers and engineers. A Philips case study was used in the development and application of the tools.
Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells

Earlier, we proposed the “mechanosome” concept as a testable model for understanding how mechanical stimuli detected by cell surface adhesion molecules are transmitted to modulate gene expression inside cells. Here, for the first time we document a putative mechanosome involving Src, Pyk2 and MBD2 in MLO-Y4 osteocytes with high spatial resolution using FRET-FLIM. Src-Pyk2 complexes were concentrated at the periphery of focal adhesions and the peri-nuclear region. Pyk2-MBD2 complexes were located primarily in the nucleus and peri-nuclear region. Lifetime measurements indicated that Src and MBD2 did not interact directly. Finally, mechanical stimulation by fluid flow induced apparent accumulation of Src-Pyk2 protein complexes in the peri-nuclear/nuclear region, consistent with the proposed behavior of a mechanosome in response to a mechanical stimulus.
Research on Coordinated Control of Reactive Power and Voltage in Large Scale Wind Farm Groups

Under the influence of the view that reactive power compensation on-spot, the study on control of reactive power and voltage in wind farms focused on a single wind farm optimal reactive voltage control. China's wind power resources are relatively concentrated and a region often have several or even a dozen wind farms. Wind farm thought as a unit to adjust often leads to irrational reactive power flow. Wind farm groups and collection substations must be thought together as a whole to manage. This paper makes use of collection substations to support area voltage, coordinates reactive power output of the wind farm groups based on the voltage sensitivity and improves the overall grid voltage level of the wind farm groups areas. Simulation results proved that the program can improve the regional power grid voltage level.
Genotyping-in-Thousands by sequencing panel development and application to inform kokanee salmon (Oncorhynchus nerka) fisheries management at multiple scales

The ability to differentiate life history variants is vital for estimating fisheries management parameters, yet traditional survey methods can be inaccurate in mixed-stock fisheries. Such is the case for kokanee, the freshwater resident form of sockeye salmon (Oncorhynchus nerka), which exhibits various reproductive ecotypes (stream-, shore-, deep-spawning) that co-occur with each other and/or anadromous O. nerka in some systems across their pan-Pacific distribution. Here, we developed a multi-purpose Genotyping-in-Thousands by sequencing (GT-seq) panel of 288 targeted single nucleotide polymorphisms (SNPs) to enable accurate kokanee stock identification by geographic basin, migratory form, and reproductive ecotype across British Columbia, Canada. The GT-seq panel exhibited high self-assignment accuracy (93.3%) and perfect assignment of individuals not included in the baseline to their geographic basin, migratory form, and reproductive ecotype of origin. The GT-seq panel was subsequently applied to Wood Lake, a valuable mixed-stock fishery, revealing high concordance (>98%) with previous assignments to ecotype using microsatellites and TaqMan® SNP genotyping assays, while improving resolution, extending a long-term time-series, and demonstrating the scalability of this approach for this system and others.
Changes in Cortical Activity during Preferred and Fast Speed Walking under Single- and Dual-Tasks in the Young-Old and Old-Old Elderly

In the elderly, walking while simultaneously engaging in other activities becomes more difficult. This study aimed to examine the changes in cortical activity during walking with aging. We try to reveal the effects of an additional task and increased walking speed on cortical activation in the young-old and the old-old elderly. Twenty-seven young-old (70.2 ± 3.0 years) and 23 old-old (78.0 ± 2.3 years) participated in this study. Each subject completed four walking tasks on the treadmill, a 2 × 2 design; two single-task (ST) walking conditions with self-selected walking speed (SSWS) and fast walking speed (FWS), and two dual-task (DT) walking conditions with SSWS and FWS. Functional near-infrared spectroscopy was applied for measurement of cerebral oxyhemoglobin (oxyHb) concentration during walking. Cortical activities were increased during DT conditions compared with ST conditions but decreased during the FWS compared with the SSWS on the primary leg motor cortex, supplementary motor area, and dorsolateral prefrontal cortex in both the young-old and the old-old. These oxyHb concentration changes were significantly less prominent in the old-old than in the young-old. This study demonstrated that changes in cortical activity during dual-task walking are lower in the old-old than in the young-old, reflecting the reduced adaptive plasticity with severe aging.
The effectiveness and efficiency of using normative messages to reduce waste: A real world experiment

Although they are only home to 16% of the global human population, high-income countries produce approximately one third of the world’s waste, the majority of which goes to landfills. To reduce pressure on landfills and natural systems, environmental messaging should focus on reducing consumption. Messages that signal social norms have the potential to influence people to reduce their consumption of comfort goods, such as straws, which are not a necessity for most people. We conducted a randomized field-experiment at a marine park in Portugal to test whether different normative messages reduced visitors’ paper straw use when compared to non-normative messages. We found that a message framed around a positive injunctive norm significantly reduced straw use compared to a non-normative message. We estimated that using the message at 17 park concession stands could keep over 27500 straws out of landfills annually and save the park money after two years.
Effects of sequential feeding with adjustments to dietary amino acid concentration according to the circadian rhythm on the performance, body composition, and nutrient balance of growing-finishing pigs

This study aimed to evaluate the effects of a sequential feeding program (SEQ) with diets varying in amino acid (AA) concentrations in the first and last 12 h of the day on the performance, body composition, and nutrient balance of growing-finishing pigs. Sixty-eight castrated male pigs were distributed in four treatments: a daily feeding program (DP) and three SEQs. In the DP, dietary requirements of AA were adjusted daily. In the SEQ, dietary daily requirements of AA were adjusted every 12 h, providing a low AA concentration in period 1 (P1; 00:00–11:59 h) and a high AA concentration in period 2 (P2; 12:00–23:59 h). In the SEQ, three different levels of low and high AA concentrations were evaluated: ±20%, ±30%, and ±40%. The experiment lasted 82 days and was divided into phase 1 (25–50 kg body weight; BW), phase 2 (50–70 kg BW), and phase 3 (70–100 kg BW). During phase 1, irrespective of dietary AA concentration, SEQ pigs had higher lysine intake, protein gain, and phosphorus efficiency than DP pigs (P ≤ 0.05). Pigs in the SEQ showed a tendency for greater average daily gain, body protein, and body lipids compared to the DP pigs (P ≤ 0.10). During phase 2, SEQ pigs showed a tendency for higher average feed intake in P2 compared to DP pigs (P = 0.07); consequently, average daily gain, body protein, and phosphorus retention tended to increase (P ≤ 0.10). During phase 3, SEQ pigs had a higher average feed intake in P2 than DP pigs (P = 0.03). However, they had a similar body composition (P > 0.05) and a tendency for higher nitrogen excretion (P = 0.06) than DP pigs. Our results suggest that SEQ is an effective approach for improving the performance and body composition of growing pigs.
Exposure to Oxy-Tetracycline Changes Gut Bacterial Community Composition in Rainbow Trout: A Preliminary Study

Simple Summary The use of antibiotics is extensive in livestock and aquaculture, although various research work is being carried out across the globe for developing alternative technologies. However, the excessive use of antibiotics leads to bio-magnification due to their stability and persistence in the environment. We assessed the gut bacterial diversity of rainbow trout grown at aquacultures in Korea exposed to oxy-tetracycline for the restriction of infections. The study revealed the changes in taxonomic units upon antibiotic treatment and prediction-based functional characterization of the gut bacterial community, providing a general overview of the abundance of particular bacterial taxa. Abstract The extensive use of antibiotics is evident in most of the livestock and aquaculture management for inhibiting pathogen infection. Korean aquaculture depends on the usage of oxy-tetracycline for growing rainbow trout. Hence, this study was conducted to evaluate the changes in gut bacterial community profiles of rainbow trout exposed to oxy-tetracycline and predict the metabolic functioning of the bacterial community. The gut bacterial community composition of oxy-tetracycline treated fish was assessed by amplicon sequencing targeting the 16S rRNA gene of bacteria and comparing with the control group that did not receive any antibiotic. The principle coordinate analysis and non-metric multidimensional scaling analysis had shown two distinct clusters that implies the changes in community composition. In phyla level, the relative abundances of Tenericutes and Firmicutes were observed to be significantly higher in oxy-tetracycline treated fish compared to the control. Furthermore, the prediction based metabolic profiling revealed the processes that are affected due to the shift in community profiles. For example, metabolic functioning of membrane efflux system, amino acid metabolism and glycolysis were significantly higher in oxy-tetracycline treated fish compared to the control. This study describes alteration in gut bacterial community composition and potential metabolic profiles of the community that might be responsible for surviving in antibiotic rich environment.
A model to foster and facilitate trust and trusting relationships in the nursing education context

Background In the nursing education context, the fostering of trust and establishing trusting relationships are important facets of teaching and learning. Aim The purpose of the study was to understand trust and trusting relationships in teaching and learning, and to develop a model to foster and facilitate trust and trusting relationships in the nursing education context. Setting Two nursing education institutions were purposively sampled that offered a comprehensive programme in nursing. Methods A grounded theory study was conducted with the aim to develop a model for trust and trusting relationships in teaching and learning. Purposive, convenience and theoretical sampling of participants were applied. The sample size consisted of 5 educators and 23 students at a university and 9 educators and 37 students at a public nursing education institution. Charmaz’s methods were used for the data analysis. Collection and analysis of data were conducted concurrently. Results Data of views from the educators and students on trust were synthesised. Themes identified were: professional relations, expectations of the role players in nursing education, creating a conducive teaching and learning context, and outcomes of lack of trust. From the findings, a substantive model to foster and facilitate trust and trusting relationships in nursing education was developed. Conclusion The study contributed to understanding trust in nursing education. Recommendations focus on fostering and facilitating self-trust and trusting relationships and also on how the model could be implemented in nursing education. Contribution Fostering and facilitating trust and trusting relationships in the nursing education context will enhance a trusting culture and contribute to the quality of teaching and learning.
Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV

Objective Women living with HIV (WLWH) experience psychosocial stress related to social-structural vulnerabilities. To investigate neuroendocrine pathways linking stress and increased cardiovascular disease risk among WLWH, we evaluated associations between psychosocial stress (i.e., perceived stress, posttraumatic stress, and experiences of race- and gender-based harassment) and a composite neuroendocrine biomarker index among WLWH and women without HIV. Methods In 2019–2020, Women’s Interagency HIV Study participants in Washington, DC completed a questionnaire and provided blood and 12-hour overnight urine samples for testing of serum dehydroepiandrosterone sulfate (DHEA-S) and urinary free cortisol, epinephrine, and norepinephrine. Psychosocial stress was measured using the Perceived Stress Scale, PTSD Checklist-Civilian Version, and Racialized Sexual Harassment Scale. Latent profile analysis was used to classify participants into low (38%), moderate (44%), and high (18%) stress groups. Composite biomarker index scores between 0–4 were assigned based on participants’ number of neuroendocrine biomarkers in high-risk quartiles (≥75th percentile for cortisol, epinephrine, and norepinephrine and ≤25th percentile for DHEA-S). We evaluated associations between latent profile and composite biomarker index values using multivariable linear regression, adjusting for socio-demographic, behavioral, metabolic, and HIV-related factors. Results Among 90 women, 62% were WLWH, 53% were non-Hispanic Black, and median age was 55 years. In full multivariable models, there was no statistically significant association between psychosocial stress and composite biomarker index values among all women independent of HIV status. High (vs. low) psychosocial stress was positively associated with higher mean composite biomarker index values among all monoracial Black women (adjusted β = 1.32; 95% CI: 0.20–2.43), Black WLWH (adjusted β = 1.93; 95% CI: 0.02–3.83) and Black HIV-negative women (adjusted β = 2.54; 95% CI: 0.41–4.67). Conclusions Despite a null association in the overall sample, greater psychosocial stress was positively associated with higher neuroendocrine biomarker concentrations among Black women, highlighting a plausible mechanism by which psychosocial stress could contribute to cardiovascular disease risk.
Prevalence of Childhood Short Stature, Underweight, Overweight, and Obesity Among Primary School Children

Background This study, the first of its kind in Morocco, was conducted to compare the prevalence of growth disorders among children enrolled in public, private, urban, and rural schools in Oujda-Angad Province. Methods A cross-sectional observational study was conducted among primary schools in Oujda-Angad Province from November 2017 to April 2018, with a stratified random cluster sampling of public, private, urban, and rural primary schools. Results A representative sample of 1582 students aged from five to 15 years old was selected. The sample included 779 females (49.2%) and 803 males (50.8%), with an average age of 9.3 ± 1.96 years. The average weight of the students was 29.3 ± 9.6 kg (range: 12-130 kg), the average height was 133.7 ± 12.16 cm (range: 104.5-175.5 cm), and the mean body mass index (BMI) was 16.05 ± 3.31 kg/m2 (range: 8.33-76.9 kg/m2). Overall, short stature (SS) and underweight were significantly more prevalent in the public and rural schools, while obesity was highest in the urban private schools that ranked as the schools with the highest socioeconomic status (SES) students (p < 0.01). Female students were more likely to be overweight and obese, while male students were more likely to be underweight. Conclusion Our study provides an estimate of the prevalence of excess weight, underweight, and short stature in a primary school population. Our results reflect the importance of the problem, the need to monitor the nutritional status at both the individual and the community level, and the need to put in place preventive, diagnostic, and early management strategies before the problem worsens.
Subnanosecond pulse propagation in a Goubau line immersed in a lossy dielectric medium

The distortion and attenuation of a subnanosecond pulse propagating along a Goubau line immersed in a lossy dielectric medium is considered in the letter. The pulse response characteristics of this line have been analysed by using a fast Fourier transform algorithm. The results of this investigation have important implications in the design of high-resolution guided-wave radar systems.
Relationship between Resting-State Alpha Coherence and Cognitive Control in Individuals with Internet Gaming Disorder: A Multimodal Approach Based on Resting-State Electroencephalography and Event-Related Potentials

The human brain is constantly active, even at rest. Alpha coherence is an electroencephalography (EEG) rhythm that regulates functional connectivity between different brain regions. However, the relationships between resting-state alpha coherence and N2/P3 components associated with response inhibition and cognitive processes have not been investigated in addictive disorders. The present study investigated the relationships between alpha coherence during the resting state and N2/P3 components of event-related potentials during the Go/Nogo task in healthy controls (HCs) and patients with Internet gaming disorder (IGD). A total of 64 young adults (HC: n = 31; IGD: n = 33) participated in this study. Alpha coherence values at left fronto-central and bilateral centro-temporal electrode sites were significantly correlated with P3 latency in HCs, whereas inverse correlations were observed in patients with IGD. Furthermore, significant differences were observed in the correlation values between the groups. Our results suggest that patients with IGD lack dynamic interactions of functional connectivity between the fronto-centro-temporal regions during the resting state and the event-related potential (ERP) index during cognitive tasks. The findings of this study may have important implications for understanding the neurophysiological mechanisms linking resting-state EEG and task-related ERPs underlying IGD.