Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection and treatment of mental disorders in patients with coronary heart disease (MenDis-CHD): A cross-sectional study

Mental disorders (MD) are associated with an increased risk of developing coronary heart disease (CHD) and with higher CHD-related morbidity and mortality. There is a strong recommendation to routinely screen CHD patients for MDs, diagnosis, and treatment by recent guidelines. The current study aimed at mapping CHD patients' (1) state of diagnostics and, if necessary, treatment of MDs, (2) trajectories and detection rate in healthcare, and (3) the influence of MDs and its management on quality of life and patient satisfaction. The design was a cross-sectional study in three settings (two hospitals, two rehabilitation clinics, three cardiology practices). CHD patients were screened for MDs with the Hospital Anxiety and Depression Scale (HADS), and, if screened-positive, examined for MDs with the Structured Clinical Interview for DSM-IV (SCID-I). Quality of Life (EQ-5D), Patient Assessment of Care for Chronic Conditions (PACIC), and previous routine diagnostics and treatment for MDs were examined. Descriptive statistics, Chi-squared tests, and ANOVA were used for analyses. Analyses of the data of 364 patients resulted in 33.8% positive HADS-screenings and 28.0% SCID-I diagnoses. The detection rate of correctly pre-diagnosed MDs was 49.0%. Physicians actively approached approximately thirty percent of patients on MDs; however, only 6.6% of patients underwent psychotherapy and 4.1% medication therapy through psychotherapists/psychiatrists. MD patients scored significantly lower on EQ-5D and the PACIC. The state of diagnostic and treatment of comorbid MDs in patients with CHD is insufficient. Patients showed a positive attitude towards addressing MDs and were satisfied with medical treatment, but less with MD-related advice. Physicians in secondary care need more training inadequately addressing mental comorbidity.
Anthropometric and Biochemical Parameters in Relation to Dietary Habits as Early Indicator of Cardiovascular Impairment in Young Adult Cohort

Adjusted dietary assessment questionnaire was used to determine dietary habits of medical students which were related to biochemical and anthropometric markers of studied cohort. Thirty-seven young and healthy volunteers aged 19–28 years old entered the protocol and were divided according to sex and according to residence. Subjects were given questionnaires for tracking food/beverage consumption. Venous blood samples were taken after overnight fast (n = 32). Nutrient status and energy consumption were determined and analyzed. Study population had normal weight and body mass index (BMI). Biochemical characteristics were within normal reference range, while some participants had lipid profile disbalance. Men had significantly higher BMI than women. Average BMI was significantly higher in participants with elevated cholesterol levels compared to participants with normal cholesterol levels. Majority of participants consumed less than five meals per day with no major differences between students according to residence and sex. Men had significantly higher protein intake and consumed at least four meals daily compared to woman who had three or less meals daily with no differences in intake according to residence. Students with normal lipid profile consumed more carbohydrates than students with increased cholesterol. Results suggest that students with bad dietary habits have potentially higher risk for future cardiovascular problems, even before the onset of adverse effects.
Exploring Barriers to and Facilitators of Physical Activity among Korean American Women

Physical inactivity is prevalent among ethnic minority women including Korean American (KA) women. We explored the barriers to and facilitators of physical activity (PA) and strategies to promote continued engagement in a PA program with a component of an online community. We conducted a qualitative descriptive study of 37 KA middle-aged women who used to be physically inactive and participated in an exit interview following postintervention visit. Using a thematic analysis approach to analyze the data, we found the individual, interpersonal, and neighborhood/community-level barriers to and facilitators of PA; social influence and social support-related themes were evident. Participants expressed benefit and interest in lifestyle modification using social media. Such program that reduces the barriers and reinforces the facilitators may be able to help motivate KA women to increase their PA.
Partitioning of Selected Anisole and Veratrole Derivatives between Water and Anionic Surfactant Micelles

The UV absorption spectra of six structurally related derivatives of anisole and veratrole, i.e., anisaldehyde, (E)-anethole, estragole, veratraldehyde, methyleugenol and (E)-methylisoeugenol, were recorded at various concentrations of the anionic surfactants, either sodium lauryl sulfate (SLS) or sodium lauryl ether sulfate (SLES) at T = 298 K. In addition, conductivity and density measurements were made for the SLS and SLES solutions to determine the volumetric properties of the studied surfactants. Next, using the W. Al-Soufi, L. Pińeiro and M. Novo model (APN model) including the pseudo-phase model for micellar solubilization, the values of micelle-water partition coefficients for each perfume-surfactant system were determined. In addition, the relations between the molecular structures of the solute and the head group of the surfactant and the value of the micelle-water partition coefficient as well as the octanol-water one were discussed.
CdSxTe1-x films: preparation and properties

CdSxTe1-x films (0<x<1) were deposited by simultaneous evaporation of CdS and CdTe powders from a vertical two-zone hot wall evaporation jig onto glass substrates. Electrical conductivity, thermoelectric and optical properties along with microstructural properties were studied in order to derive information on the electron transport processes in the films. Raman scattering was also studied for the films.
New aromatic sesquiterpenes from a Halichondria sp

Three new aromatic sesquiterpenes have been isolated from a Halichondria sp, found off the Western Australian coast. Evidence is presented for the structure of (1'Z)- and (1'E)-2-(1',5'-dimethylhexa- 4'-dienyl)-5-methylbenzene-1,4-diol and of (1'E)-2-(1',5'-dimethylhexa-1',4'-dienyl)-5-methyl-phenyl acetate.
Synthesis of Methyl tert-Butyl Ether Catalyzed by Acidic Ion-Exchange Resins. Influence of the Proton Activity

The catalytic activity of various strong acid ion-exchange resins on the synthesis of methyl tert-butyl ether (MtBE) from methanol and isobutene has been investigated. Relative to Amberlyst 15, Kastel CS 381 and Amberlyst CSP have similar rate constants, whereas Duolite ES 276 and Amberlyst XE 307 have significantly higher and Duolite C26 and Duolite C16P substantially lower rate constants. All resins show a great decrease in catalytic activity if part of the protons is exchanged by sodium ions. At 10% proton capacity the rate constants per equivalent acid are reduced by a factor of 9 (for Amberlyst XE 307 and Kastel CS 381) to more than a factor 20 for Amberlyst 15 and Duolite ES 276, resulting in 100-200 times lower MtBE production rates. Depending on the catalyst applied, mass transfer limitations start to occur between 50 and 80 degrees C. Values of the effective diffusion coefficient of isobutene varied between 0.4 x 10(-9) and 4.1 x 10(-9) m(2) s(-1) at 80 degrees C.
Effects of Polygenic Risk and Perceived Friends' Drinking and Disruptive Behavior on Development of Alcohol Use Across Adolescence.

OBJECTIVE Developmental theory posits interacting individual and contextual factors that contribute to alcohol use across adolescence. Despite the well-documented salience of peer environmental influences on adolescent drinking, it is not known whether peer environments moderate polygenic risks for trajectories of alcohol use. The current theoretically based investigation aimed to test developmental gene-environment interaction (G×E) effects across adolescence. METHOD Latent growth curve models tested interactive associations of polygenic risk scores and adolescents' perceived friend drinking and disruptive behavior with adolescents' initial level of alcohol use frequency at age 16 years old and change in alcohol frequency from ages 16 to 20. The sample comprised 8,941 White adolescents (49% female) from Great Britain within the Avon Longitudinal Study of Parents and Children (ALSPAC). RESULTS Greater polygenic risk was associated with more frequent initial drinking as well as escalations in drinking frequency over the subsequent 5 years in latent growth curve models. Contrary to study hypotheses, no significant G×E effects were identified after controlling for confounding main and interaction effects. CONCLUSIONS Adolescents at heightened genetic risk may accelerate their alcohol use across adolescence, although not significantly more so in the presence of these alcohol-promoting peer environments. Future well-powered, theoretically driven replication efforts are needed to examine generalizability of these findings across diverse samples.
Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol

Myocardial remodelling is important pathological basis of HF, mitochondrial oxidative stress is a promoter to myocardial hypertrophy, fibrosis and apoptosis. ECH is the major active component of a traditional Chinese medicine Cistanches Herba, plenty of studies indicate it possesses a strong antioxidant capacity in nerve cells and tumour, it inhibits mitochondrial oxidative stress, protects mitochondrial function, but the specific mechanism is unclear. SIRT1/FOXO3a/MnSOD is an important antioxidant axis, study finds that ECH binds covalently to SIRT1 as a ligand and up‐regulates the expression of SIRT1 in brain cells. We hypothesizes that ECH may reverse myocardial remodelling and improve heart function of HF via regulating SIRT1/FOXO3a/MnSOD signalling axis and inhibit mitochondrial oxidative stress in cardiomyocytes. Here, we firstly induce cellular model of oxidative stress by ISO with AC‐16 cells and pre‐treat with ECH, the level of mitochondrial ROS, mtDNA oxidative injury, MMP, carbonylated protein, lipid peroxidation, intracellular ROS and apoptosis are detected, confirm the effect of ECH in mitochondrial oxidative stress and function in vitro. Then, we establish a HF rat model induced by ISO and pre‐treat with ECH. Indexes of heart function, myocardial remodelling, mitochondrial oxidative stress and function, expression of SIRT1/FOXO3a/MnSOD signalling axis are measured, the data indicate that ECH improves heart function, inhibits myocardial hypertrophy, fibrosis and apoptosis, increases the expression of SIRT1/FOXO3a/MnSOD signalling axis, reduces the mitochondrial oxidative damages, protects mitochondrial function. We conclude that ECH reverses myocardial remodelling and improves cardiac function via up‐regulating SIRT1/FOXO3a/MnSOD axis and inhibiting mitochondrial oxidative stress in HF rats.
Production Performance, Nutrient Digestibility, and Milk Composition of Dairy Ewes Supplemented with Crushed Sunflower Seeds and Sunflower Seed Silage in Corn Silage-Based Diets

Simple Summary In countries such as Mexico and the Unites States, sunflowers can be planted earlier than corn, and can tolerate moderate frosts. Concerning sunflower silage, its feeding value could be up to 80% similar to that of corn silage. The use of sunflower silage for ruminant feeding represents an alternative to the use of corn silage, especially when environmental conditions are adverse for corn crops. Sunflower seeds can also be a protein alternative to soybean by-products. This study determined production performance, nutrient digestibility, and milk composition of dairy ewes fed with crushed sunflower seeds (SF) and sunflower seed silage (SFS) in corn silage-based diets. Compared to control, SF and SFS increased intake and digestibility of fiber components, such as neutral detergent fiber (NDF) and acid detergent fiber (ADF). Nitrogen balance, milk yield, milk fat yield, and milk protein yield were similar between treatments. Results demonstrated that crushed sunflower seeds and ensiled seeds do not change significantly productive parameters of dairy sheep. In corn-silage based diets, both crushed and ensiled sunflower seeds can be used in dairy sheep diets as alternatives to typical protein feedstuffs, such as soybean meal. Abstract This study determined production performance, nutrient digestibility, and milk composition of dairy ewes supplemented with crushed sunflower seeds (Helianthus annuus) and sunflower seed silage in corn silage-based diets. Six ewes were grouped in a double 3 × 3 Latin square design with three periods of 21 days. All treatments were based on ad libitum corn silage. Control diet was based on alfalfa hay (333 g/kg DM), sorghum grain (253 g/kg DM), triticale grain (200 g/kg DM), soybean meal (167 g /kg DM), and vitamin and mineral premix (47 g/kg DM). Sunflower seeds (SF) and sunflower seed silage (SFS) treatments consisted of alfalfa hay (333 g/kg DM), sorghum grain (267 g/kg DM), triticale grain (100 g/kg DM), soybean meal (167 g /kg DM), SF or SFS (87 g/kg DM) and vitamin and mineral premix (47 g/kg DM). Compared to control, SF and SFS increased intake and digestibility of fiber components, such as neutral detergent fiber (NDF) and acid detergent fiber (ADF). Body weight, nitrogen balance, milk yield, milk fat yield, milk protein yield, lactose yield and milk urea N were similar between treatments. Overall, results demonstrated that crushed sunflower seeds and ensiled seeds do not change significantly productive parameters of dairy sheep.
Salmonella Paratyphi A Outer Membrane Vesicles Displaying Vi Polysaccharide as a Multivalent Vaccine against Enteric Fever

Typhoid and paratyphoid fevers have a high incidence worldwide and coexist in many geographical areas, especially in low-middle-income countries (LMIC) in South and Southeast Asia. There is extensive consensus on the urgent need for better and affordable vaccines against systemic Salmonella infections. ABSTRACT Typhoid and paratyphoid fevers have a high incidence worldwide and coexist in many geographical areas, especially in low-middle-income countries (LMIC) in South and Southeast Asia. There is extensive consensus on the urgent need for better and affordable vaccines against systemic Salmonella infections. Generalized modules for membrane antigens (GMMA), outer membrane exosomes shed by Salmonella bacteria genetically manipulated to increase blebbing, resemble the bacterial surface where protective antigens are displayed in their native environment. Here, we engineered S. Paratyphi A using the pDC5-viaB plasmid to generate GMMA displaying the heterologous S. Typhi Vi antigen together with the homologous O:2 O antigen. The presence of both Vi and O:2 was confirmed by flow cytometry on bacterial cells, and their amount was quantified on the resulting vesicles through a panel of analytical methods. When tested in mice, such GMMA induced a strong antibody response against both Vi and O:2, and these antibodies were functional in a serum bactericidal assay. Our approach yielded a bivalent vaccine candidate able to induce immune responses against different Salmonella serovars, which could benefit LMIC residents and travelers.
Solid phase epitaxy of β‐FeSi2 on Si(100)

Orthorhombic β‐FeSi2 is a semiconducting material with a direct band gap of about 0.87 eV, which makes it an active component in light detectors and near‐infrared sources. Solid phase epitaxy (SPE) has been used as the conventional method to grow epitaxial β‐FeSi2 films. In this article, we report on the SPE of β‐FeSi2 films using Fe/Si(100) heterostructures obtained by metalorganic chemical vapor deposition (MOCVD). The formation processing of the β‐FeSi2 thin films includes the deposition of iron on Si(100) by MOCVD and a subsequent annealing. The highly textured Fe layer deposited on the silicon substrate was tested by x‐ray diffraction (XRD) and electron microscopy techniques. The β‐FeSi2 film was successfully formed after the annealing process. The better epitaxy of β‐FeSi2 on Si(100) was evidenced by XRD measurements. It was also confirmed by Raman spectra measurements, in which some main Raman lines were clearly detected. Optical transmission measurements revealed a strong absorption of β‐FeSi2 nea.
Synthesis and properties of new chlorin and bacteriochlorin photosensitizers

A series of novel sensitizers, which absorb in the range of 660 - 820 nm, derived from natural occurring chlorophyll and bacteriochlorophyll was synthesized. Biomass of blue-green algae Spirulina platensis was used to prepare chlorophyll a derivatives, and biomass of purple bacteria Rhodobacter capsulatus was applied for preparation of bacteriochlorophyll a. The influence of different substituents on spectral characteristics and the amphipility of the sensitizer was investigated. The route for the synthesis of porphyrin macrocycle with the spacer that bears the isothiocyanate group capable for binding with proteins was proposed. Photophysical properties of chlorin p6, purpurin 18 and their esters in different solvents are investigated. Accumulation of two chlorins in the model Erlich tumor was studied.
Uterine Transplantation: Review of Livebirths and Reproductive Implications

Uterine transplantation (UTx) is a fertility restoring treatment for women with absolute uterine factor infertility. At a time when there is no question of the procedure’s feasibility, and as the number of livebirths begins to increase exponentially, various important reproductive, fetal, and maternal medicine implications have emerged. Detailed outcomes from 17 livebirths following UTx are now available, which are reviewed herein, along with contextualized extrapolation from pregnancy outcomes in other solid organ transplants. Differences in recipient demographics and reproductive aspirations between UTx and other transplant recipients make extrapolating management strategies and outcomes in other solid organ transplants inappropriate. Whereas preterm delivery remains prominent, small for gestational age or hypertensive disorders do not appear to be as prevalent following UTx when compared to other solid organ transplants. Given the primary objective of undertaking UTx is to achieve a livebirth, publication of reproductive outcomes is essential at this early stage, to reflect on and optimize the management of future cases.
The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle

Meizoso-Huesca and Launikonis describe multiple effects of BTP2, an inhibitor of the Ca2+ channel Orai1, on Ca2+ handling in skeletal muscle, which include impairment of Ca2+ release from the sarcoplasmic reticulum and indirect effects on the activity of the ryanodine receptors.
Executive function mediates the link between externalizing behavior and HbA1c in children and adolescents with type 1 diabetes: A cross‐national investigation

Externalizing behavior (i.e., conduct problems, hyperactivity) and executive function (EF) problems in children and adolescents with type 1 diabetes (T1D) have been associated with worse diabetes‐related and psychosocial outcomes but have not been examined in relationship to each other. We aimed to examine whether externalizing behavior is associated with HbA1c and whether this relationship is mediated by EF problems, specifically metacognition (i.e., ability to initiate, plan, organize and monitor behavior) and behavioral regulation (i.e., impulse control, regulation of emotion and behavior).
The Transcription Regulator and c-di-GMP Phosphodiesterase PdeL Represses Motility in Escherichia coli

Bacteria adopt different lifestyles depending on their environment and physiological conditions. In Escherichia coli and other enteric bacteria, the transition between the motile and the sessile states is controlled at multiple levels from the regulation of gene expression to the modulation of various processes by the second messenger c-di-GMP as a signaling molecule. ABSTRACT PdeL is a transcription regulator and catalytically active c-di-GMP phosphodiesterase (PDE) in Escherichia coli. PdeL has been shown to be a transcription autoregulator, while no other target genes have been identified so far. Here, we show that PdeL represses the transcription of the flagellar class II operon fliFGHIJK and activates sslE, encoding an extracellularly anchored metalloprotease, among additional loci. DNA-binding studies and expression analyses using plasmidic reporters suggest that the regulation of the fliF and sslE promoters by PdeL is direct. Transcription repression of the fliFGHIJK operon, encoding proteins required for the assembly of the flagellar basal body, results in inhibition of motility on soft-agar plates and reduction of flagellum assembly, as shown by fluorescence staining of the flagellar hook protein FlgE. PdeL-mediated repression of motility is independent of its phosphodiesterase activity. Thus, in motility control, the transcription regulator function of PdeL in reducing the number of assembled flagella is apparently epistatic to its phosphodiesterase function, which can indirectly promote the activity of the flagellar motor by lowering the c-di-GMP concentration. IMPORTANCE Bacteria adopt different lifestyles depending on their environment and physiological conditions. In Escherichia coli and other enteric bacteria, the transition between the motile and the sessile states is controlled at multiple levels from the regulation of gene expression to the modulation of various processes by the second messenger c-di-GMP as a signaling molecule. The significance of our research is in identifying PdeL, a protein of dual function that hydrolyzes c-di-GMP and regulates the transcription of genes, as a repressor of flagellar gene expression and an inhibitor of motility, which adds an additional regulatory switch to the control of motility.