Miracle-dz/UniFAR-FTUs huggingface dataset:
An Investigation of the Effects of Selenium on Histone Acetylation

Histones are an important component of DNA, affecting both transcription and translation within the cell. DNA in our cells is wound around an octomer of four core histone proteins. Post-translational covalent modifications of these histones at specific residues, including acetylation, methylation, and phosphorylation, can lead to the activation or repression of gene transcription. Histone acetylation, performed by histone acetyltransferases (HATs), is of particular interest because it can lead to the activation of inflammatory genes and pathways in the body. Mutated or malfunctioning HATs can also lead to disease, and may be future targets for cancer therapies. Because of these links between inflammation and disease, it is important to understand histone acetylation and how it is regulated. It has been shown that selenium has anti-inflammatory properties by serving as an antioxidant and by increasing the production of anti-inflammatory prostaglandins in macrophages. Because of the effects of selenium on inflammation, it is believed that selenium may affect HATs and cause a reduction in histone acetylation, decreasing the activation of inflammatory genes. This investigation takes a look at the effects of different concentrations of selenium on histone acetylation on H4K5, H4K8, H4K12, and H4K16 residues in macrophages and hepatocytes. Our results do in fact show that selenium supplementation reduces histone acetylation on H4 residues in both macrophages and hepatocytes.
Evaluation of Safety and Successfulness of the Coil Embolization of Intracranial Aneurysms

Abstract Intracranial aneurisms are ongoing problem for neurosurgeons and especially for interventional neuroradiologists due to its morbidity and mortality. The method of choice for treatment of the unruptured and ruptured intracranial aneurysms is endovascular coiling on account of its minimal invasiveness and high effectiveness. The aim of our study was to evaluate the safety and successfulness of endovascular coiling procedure in unruptured and ruptured intracranial aneurysms. Our study was designed as case series and consisted of patients older than 18 years, who underwent endovascular coiling of unruptured and ruptured intracranial aneurysms and follow-up examination 6 months after the interventional procedure. The procedures were performed from December 2010 to December 2016, by experienced interventional neuroradilogists (more than 400 performed embolizations each) at the Department for Interventional Neuroradiology, Clinical Center Kragujevac, Serbia. There were 681 patients (average age 47.5 ± 11.2 years) treated with endovascular coiling, out of them 324 (234 females, 90 males) had unruptured intracranial aneurysm and 357 (138 females, 219 males) had ruptured intracranial aneurysm. In our series, total complication rate was 11.71 %. Analysis of the results after first endovascular procedure has shown that complete aneurysm occlusion was accomplished in 546 patients (80.3%), near-complete in 81 patients (11.8%), and incomplete in 54 patients (7.9 %). Our results were satisfying regarding the procedure’s success, safety, outcomes and study material. However, further technical development of the materials and constant training of the interventional radiologists, are a necessity in order to improve treatment outcomes and patients’ benefit.
Convergence of coprime factor perturbations for robust stabilization of Oseen systems

Linearization based controllers for incompressible flows have been proven to work in theory and in simulations. To realize such a controller numerically, the infinite dimensional system has to be linearized and discretized. The unavoidable consistency errors add a small but critical uncertainty to the controller model which will likely make it fail, especially when an observer is involved. Standard robust controller designs can compensate small uncertainties if they can be qualified as a coprime factor perturbation of the plant. We show that for the linearized Navier-Stokes equations, a linearization error can be expressed as a coprime factor perturbation and that this perturbation smoothly depends on the size of the linearization error. In particular, improving the linearization makes the perturbation smaller so that, eventually, standard robust controller will stabilize the system.
Experimental protocols used for the characterization of fungal secretomes

Microorganisms, although being very diverse because they comprise prokaryotic organisms such as bacteria or eukaryotic organisms such as fungi, all share an essential exodigester function. The consequence is their essential need to have a secretome adapted to their environment. The selection pressure exerted by environmental constraints led to the emergence of species with varying complexity in terms of composition of their secretomes. This review on fungal secretomes highlights the extraordinary variability among these organisms, even within the same species, and hence the absolute necessity to fully characterize all their components in the aims of understanding the fundamental mechanisms responsible for secretome plasticity and developing applications notably toward a better control of diseases caused by these pathogens.
Meiobenthic copepod fauna of a marine cave (NW Mediterranean) closely resembles that of deep-sea communities

The 3PP marine cave near Marseille (NW Mediterranean) is at a depth of only 15 m. Nevertheless, the cave is a unique deep-sea-like habitat zone due to total darkness, lack of water circulation, oligotrophy, and cold homothermy, a thermal regime similar to that of the deep Mediterranean. We studied the meiofaunal community composition and diversity at 3 sampling stations in the cave (entrance, middle, and blind end). Major taxon composition, based on presence/absence data, did not vary over the transect; however, significant differences in community were found. Tardigrades were the only major taxon restricted to the inner parts of the cave. Copepod diversity decreased towards the inner parts of the cave. The 3PP Cave was characterized by very low abundances of meiofaunal organisms similar to abyssal sites elsewhere. A total of 405 individual copepods were assigned to 27 families and 90 species (75% of them new to science). Significant differences in copepod communities between stations were found at family, genus, and species level. Some harpacticoid taxa generally known from the deep sea, such as Marsteinia, Ancorabolina, Paranannopus, Nematovorax, and Argestidae, were represented in the 3PP Cave. A naive Bayes model was used for the first time to classify the communities as 'shallow' or 'abyssal'. The meiobenthic communities at the entrance and the end of the cave were unequi vocally classified as 'shallow' and 'abyssal' respectively, while the middle part of the cave presented a mixed community. Our study further highlights the strong faunal and community affinities between marine caves and the deep sea, indicating the existence of dispersal mechanisms from deep waters into the euphotic zone for benthic organisms.
The Prognosis of Influence of The Oder River Waters Dammed by Malczyce Barrage on Left Bank Areas

Abstract The finalisation of the construction of the Malczyce barrage is planned for 2015. Damming of the river will cause a change in the water and ground conditions in the adjoining areas. The paper analyses the influence of the water level in the Oder River dammed by the barrage on groundwater table level in the left bank valley. A model which allows the prediction of groundwater levels depending on the assumed water level in the Oder was constructed. The analysis was conducted for three different variants: for the initial stage before damming the Oder River and for the conditions after damming the water up with and without the drainage devices included in the project. The calculations were done in several chosen transects across the river valley. The mathematical model of flow in the aquifer based on the Richards equation was applied. The results of calculations were presented as the spatial distribution of piezometric pressures which were used to determine the groundwater table for each of the transects. The calculation results from the vertical models were transposed into a horizontal model. The comparison of appropriate results allowed to positively verify the designed model and to analyse the effectiveness of the realised project solutions.
Nonreversible Jump Algorithms for Bayesian Nested Model Selection

Abstract Nonreversible Markov chain Monte Carlo methods often outperform their reversible counterparts in terms of asymptotic variance of ergodic averages and mixing properties. Lifting the state-space is a generic technique for constructing such samplers. The idea is to think of the random variables we want to generate as position variables and to associate to them direction variables so as to design Markov chains which do not have the diffusive behavior often exhibited by reversible schemes. In this article, we explore the benefits of using such ideas in the context of Bayesian model choice for nested models, a class of models for which the model indicator variable is an ordinal random variable. By lifting this model indicator variable, we obtain nonreversible jump algorithms, a nonreversible version of the popular reversible jump algorithms. This simple algorithmic modification provides samplers which can empirically outperform their reversible counterparts at no extra computational cost. The code to reproduce all experiments is available online 1 .
Describing Meta-Atoms Using the Exact Higher-Order Polarizability Tensors

In nanophotonics, multipole framework has become an indispensable theoretical tool for analyzing subwavelength meta-atoms and their radiation properties. This work presents higher-order exact dynamic polarizability (alpha) tensors, which can fully represent anisotropic meta-atoms with higher-order multipole transitions. By using the irreducible exact Cartesian multipoles and field components as the basis, the exact alpha-tensor rigorously reflects symmetry information of particles including reciprocity. In addition, the exact alpha-tensor can be obtained from T-matrix simply using basis transformation. Finally, we show that description of meta-atoms using alpha-tensors incorporated with multiple-scattering theory vastly extends the applicability of the multipole framework in nanophotonics, allowing accurate and efficient depiction of complicated, random, multi-scale systems.
Optimal Experiment Strategy to Improve Trustability Testing of Management Information Systems

경영정보시스템(MIS)의 실패는 막대한 개발비용의 손실과 변화하는 경영환경에 대한 적시적 대응의 지연 을 초래한다. MIS가 경영요구사항에 따라 충실하게 개발되는지를 검증하기 위해서뿐만 아니라, 가능한 오류 를 발견하고 정정하기 위해서 시험은 반드시 수행되어야 한다. MIS의 효과적인 시험을 위한 기준을 마련하기 위해서, 시험의 기본적인 수행을 제시하기 위한 신뢰성 모형이 필요하다. 검출력과 신뢰성에 기반한 모형은 이 시험방법과 조합을 찾는데 있어서 매우 유용하다. 신뢰성 모형으로부터 추출된 분석모형의 효과성을 검증 하기 위해서는, 성과비교가 다양한 환경에서 가능한 추적실험이 필수적이다. 그래서, 우리는 사전단계에 있는 MIS의 실패를 해결하기 위한 효과적인 시험에 관해 연구하였다. 우선, 시험 모형을 구축하여, MIS 시험 및 신뢰성 모형 적용과 관련된 전통적인 시험들의 몇몇 단점을 발견하였다. 그리고 추적시험을 위해 약간의 설 정을 고려한 신뢰성 모형에 기반하여 최적화된 시험모형을 개발하고 제안하였다. 마지막으로, 이 설계된 신 뢰성 모형이 어떻게 효과적인지에 관해 분석하였다.
Antioxidant activity of silybin and 2,3-dehydrosilybin from Silybum marianum (L). Gaertn. Fruits

Silybin (1) and 2,3-dehydrosilybin (2) were isolated from fruits of milk thistle [Silybum marianum (L). Gaertn. ] сultivated in the Samara region (Russian Federation). 2,3-dehydrosilybin for the first time is described for the given plant, cultivated in Russian Federation. Silybin and 2,3-dehydrosilybin and also the fluid extract of Silybum marianum fruits (the ratio of the fruits and 80% ethanol is 1:1) have expressed antioxidant activity, decreasing the level of the lipid peroxidation caused FeSO4 in the homogenate of the liver rats. The antioxidant activity of 2,3-dehydrosilybin is reported for the first time and on 14,0% above those of silybin.
High-order harmonic generation in solid slabs beyond the single-active-electron approximation

High-harmonic generation by a laser-driven solid slab is simulated using time-dependent density functional theory. Multiple harmonic plateaus up to very high harmonic orders are observed already at surprisingly low field strengths. The full all-electron harmonic spectra are, in general, very different from those of any individual Kohn-Sham orbital. Freezing the Kohn-Sham potential instead is found to be a good approximation for the laser intensities and harmonic orders considered. The origins of the plateau cutoffs are explained in terms of band gaps that can be reached by Kohn-Sham electrons and holes moving through the band structure.
ANALYSIS OF INDUCED MUTANTS OF SALINITY RESISTANT BANANA (MUSA ACUMINATA CV. DWARF CAVENDISH) USING MORPHOLOGICAL AND MOLECULAR MARKERS

Genetic diversity amongst 21 induced mutant clones tolerant to salinity along with one non-irradiated sensitive clone of banana (Musa acuminata cv. Dwarf Cavendish (AAA)) were studied using morphological and random amplified polymorphic DNA (RAPD) markers. Out of the 30 phenotypic indices screened, 23 were polymorph and two traits, leaf habit and blotches color, were differentiated by non-irradiated clone. RAPDs established 106 major amplified products using 14 primers. Out of 106 markers, eight were monomorph, and the remaining (98) were polymorph. The extent of polymorphism indicated the existence of considerable variation DNA level within induced mutant clones. Primer OPA-02 revealed banding patterns specific to salinity resistant clones. Both morphological and RAPD analyses successfully detected genetic variation within induced mutant clones, RAPD also detected variation between the irradiated and non-irradiated clones, which were morphologically indistinguishable. Results were indicative that induced mutations bear a great potential in improving banana for salinity resistant.
Putative drivers of adrenocortical activity in captive African lesser bushbaby, Galago moholi

In seasonal breeders, periods of reproductive activity often coincide with high levels of glucocorticoids. We studied seven male and seven female African lesser bushbabies (Galago moholi A. Smith, 1836) over two mating periods via noninvasive faecal hormone metabolite monitoring to investigate the relationship between reproductive and adrenocortical hormone activity. We used linear mixed-effect models to investigate the effect of physiological (endocrine) variables on faecal glucocorticoid metabolite concentrations. Our results indicate faecal androgen (males) and progestagen metabolite (females) concentrations as the variables best able to explain variability in faecal glucocorticoid metabolite concentrations. However, the models explained only a fraction (26% and 12%, respectively) of the observed variability and graphical analysis suggests a biologically relevant difference in faecal glucocorticoid metabolite concentrations between captive and free-ranging animals during nonreproductive periods. Thus, captivity may have affected glucocorticoid output in our focal animals, potentially weakening the expected relationship between reproductive activity and faecal glucocorticoid metabolite variability. Due to the ease of faecal and observational sample collection, a large number of studies monitoring adrenocortical activity in wildlife are conducted using only captive settings, with inferences unquestioned when applied to free-ranging scenarios. Our study cautions against this practice, as particular housing or management conditions may influence the pattern of adrenocortical activity.
How Mergers May Affect the Mass Scaling Relation between Gravitationally Bound Systems

Supermassive black hole (BH) masses () are strongly correlated with galaxy stellar bulge masses (), and there are several ideas to explain the origin of this relationship. This study isolates the role of galaxy mergers from considerations of other detailed physics to more clearly show how a linear BH-galaxy mass relation (-) can naturally emerge, regardless of how primordial BHs were seeded inside galaxies, if the galaxy mass function declines with increasing mass. Under this circumstance, the - relation is a passive attractor that eventually converges to a tight linear relation because of two basic statistical effects: a central-limit-like tendency for galaxy mergers, which is much stronger for major mergers than for minor mergers, and a convergence toward a linear relation that is due mainly to minor mergers. A curious consequence of this thought experiment is that if galaxy bulges are formed by major mergers, then merger statistics naturally show that will correlate more strongly with bulge-dominated galaxies, because of stronger central-seeking tendencies, than with disk-dominated galaxies. Even if some other physics is ultimately responsible for causing a linear - relationship, this thought experiment shows that, counter to intuition, random merging of galaxies that harbor random BH masses tends to strengthen rather than weaken a preexisting, linear, correlation. This idea may be generalized to other gravitationally bound systems (dark matter halos, compact nuclear objects) that retain their physical identities after experiencing mergers.
Appendix for “Private Pensions, Retirement Wealth and Lifetime Earnings”

We examine two measures of retirement wealth, where “retirement” refers to the year the household head turns 65. The first is the PSID variable Wealth2 (which we refer to as net worth), which includes financial wealth, private annuities, IRAs, real estate, business wealth, vehicles, life insurance policies, trusts and other assets less debts. This is available for a 1984, 1989, 1994, 1999, 2001, 2003, and 2005. Summary statistics for households for whom we have an estimate of net worth are reported in Table 1. The majority of the single households in the sample are female. Overall, the characteristics of this sample are similar to Hendricks (2007), who looks at data from the 1968-2003 PSID (see below). The second wealth measure we examine adds employer provided pensions (both defined contribution plans and defined benefit plans) to Wealth2, and is available biannually
Developing a conceptual model for examining the supply chain relationships between behavioural antecedents of collaboration, integration and performance

Purpose – The purpose of this paper is threefold: first, review the literature on the topic of behavioural antecedents of collaboration and their impact on supply chain integration and performance; second, lay the theoretical foundations and develop a conceptual model linking behavioural antecedents of collaboration, information integration, coordination of operational decisions and supply chain performance; and third, set out operationalisation considerations. Design/methodology/approach – A conceptual model with theoretical basis on Relational Exchange Theory (RET) and extant supply chain theory is developed as a causal model that can be operationalised using structural equations modelling (partial least squares) and a “single key informant” approach. Findings – Positive relationships between behavioural antecedents of collaboration (trust, commitment, mutuality/reciprocity), information integration, coordination of operational decisions and supply chain performance (efficiency, effectiveness) are hypot.
Haze of surface random systems: An approximate analytic approach

Approximate analytic expressions for haze (and gloss) of Gaussian randomly rough surfaces for various types of correlation functions are derived within phase-perturbation theory. The approximations depend on the angle of incidence, polarization of the incident light, the surface roughness, $\ensuremath{\sigma}$, and the average of the power spectrum taken over a small angular interval about the specular direction. In particular it is demonstrated that haze (gloss) increase (decrease) with $\ensuremath{\sigma}/\ensuremath{\lambda}$ as $\text{exp}[\ensuremath{-}A{(\ensuremath{\sigma}/\ensuremath{\lambda})}^{2}]$ and decreases (increase) with $a/\ensuremath{\lambda}$, where $a$ is the correlation length of the surface roughness, in a way that depends on the specific form of the correlation function being considered. These approximations are compared to what can be obtained from a rigorous Monte Carlo simulation approach, and a good agreement is found over large regions of parameter space. Some experimental results for the angular distribution of the transmitted light through polymer films and their haze are presented and compared to the analytic approximations derived in this paper. A satisfactory agreement is found. In the literature haze of blown polyethylene films has been related to surface roughness. Few authors have quantified the roughness and others have pointed to the difficulty in finding the correct roughness measure.
MODELLING DISPERSIVE BEHAVIOR OF EXCITABLE CELLS

Most of the materials have nearly constant electromagnetic characteristics at low frequencies. Nonetheless, biological tissues are not the same; they are highly dispersive, even at low frequencies. Cable theory is the most famous method for analyzing nerves though a common mistake when studying the model is to consider a constant parameter versus frequency. This issue is discussed in the present article, and the analysis of how to model the dispersion in the cable model is proposed and explained. The proposed dispersive model can predict the behavior of excitable cells versus stimulations with single frequency or wide-band signals. In this article, the nondestructive external stimulation by a coil is modeled and computed by finite difference method to survey the dispersion impact. Also, 5% to 80% difference is shown between the results of dispersive and nondispersive models in the 5 Hz to 4 kHz investigation. The disagreement expresses the dispersion notability. The proposed dispersive method assists in accurate device design and signal form optimization. Noise analysis is also achieved by this model, unlike the conventional models, which is essential in the analysis of single neurons or central nervous system, EEG and MEG records.
Vitamin D receptor ( Bsm I ) genotypes influence inflammatory and oxidative stress responses to altered vitamin D intake in subjects with Type 2 diabetes : A randomized controlled trial

Vitamin D receptor (BsmI) genotypes influence inflammatory and oxidative stress responses to altered vitamin D intake in subjects with Type 2 diabetes: A randomized controlled trial Sakineh Shab-Bidar, Tirang R. Neyestani*, Abolghassem Djazayery a Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran b Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute AND School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran