Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of global disaster competency development program on paramedic and nursing undergraduate students

연구 목적 : 우리나라는 인도주의적 차원에서 국제구조대와 한국재난대응팀을 파견하고 있으며 이는 공적개발원조의 하나인 해외긴급구호활동에 해당하는 것으로 주로 소방대원과 의료인들이 활동하고 있다. 따라서 이 연구는 글로벌 재난 역량 개발 프로그램이 응급구조과와 간호학과 학생들에게 어떠한 영향을 미쳤는지 살펴보고 이를 통해서 추후 학부교육에 대한 개선방안을 모색하고자 한다. 연구 방법 : 본 프로그램은 ICN에서 제시한 "재난간호역량체계"를 기본 틀로 4개 영역 10개 도메인으로 역량을 구분하여 프로그램을 설계하였다. 프로그램은 2013년 8월 12일부터 23일까지 2주간 사례학습, 토론, 전문가 특강, 태국 카렌지역 현지방문 등 다양한 방식으로 운영되었으며 참석학생은 총 18명이었다. 프로그램에 대한 만족도는 5점 척도로 측정하였고, 국제재난역량 지식수준은 10점 척도로 측정하여 프로그램 전후 지식수준을 비교분석하였다. 그 외 심층 인터뷰를 진행하여 재난에 대한 학생들의 태도 변화를 보았다. 연구 결과 : 프로그램 만족도는 $4.50{\pm}0.51$ 로 매우 높았으며 국제재난관련 지식의 변화는 전체 항목 평균 $2.18{\pm}0.68$ 에서 $6.30{\pm}0.84$ 로 상승하였다(p 【Purpose : This study assessed the improvement of competency levels for participants, as well as their satisfaction from completion of the special international disaster response program. Methods : The program structure followed an intensive two-week course that included a combination of lectures, discussions, case studies, and field trips. "ICN Framework of Disaster Nursing Competencies" was used for designing the program. A pre-post survey was done to measure the change in the competencies of students and assess their satisfaction after finishing the program. Focus group interviews were also performed to further understand the attitudes of participants toward the disaster issues. Results : The overall pre-program test score for disaster competency was $2.18{\pm}0.68$ and the post-program test score was $6.30{\pm}0.84$ , which showed statistically significant gains in all competency items (p $4.5{\pm}0.51$ . The benefits for students from program participation included increased knowledge and better understanding of the important roles of international organizations and NGOs. Conclusion : The international disaster education programs are necessary to provide an opportunity for students to increase their disaster competency. In addition, future development of a unified educational competency framework is also necessary. 】
Hydrogen-bonded layers directed by the [3-O3S-C6H4-PO3H]2- dianion: catena-poly[[silver(I)-mu-4,4'-bipyridine-kappa2N:N'] 3-[hydroxy(oxido)phosphinoyl]benzenesulfonate trihydrate] and catena-poly[[[tetraaquacobalt(II)]-mu-4,4'-bipyridine-kappa2N:N'] 3-[hydroxy(oxido)phosphinoyl]benzenesulfonate].

Both title compounds, {[Ag(2)(C(10)H(8)N(2))(2)](C(6)H(5)O(6)PS). 3H(2)O}(n), (I), and {[Co(C(10)H(8)N(2))(2)(H(2)O)(4)](C(6)H(5)O(6)PS)}(n), (II), respectively, contain similar novel symmetric dimeric [O(3)S-C(6)H(4)-PO(3)H](2-) anions formed via two shared (O.H.O) H atoms on twofold positions between two -PO(3)H(-) groups. The two-coordinate Ag(I) structure features one-dimensional polymeric chains of {[Ag(4,4'-bipy)](2)(2+)}(n) (4,4'-bipy is 4,4'-bipyridine), weakly linked by pi-pi interactions, separated by the anionic dimers which are stabilized into layers by hydrogen bonding to three water molecules. In (II), a twofold crystallographic axis runs through the one-dimensional {[Co(4,4'-bipy)(H(2)O)(4)](2+)}(n) chains containing six-coordinate Co(II); three-dimensional packing is provided by hydrogen bonding using all sulfonate and -PO(3)H(-) O atoms as acceptors and the Co-bound water H atoms as donors. In this latter case, the benzenesulfonate aromatic rings are also constrained to a mirror plane. This report illustrates how a previously unreported dianion can affect the crystallization of polymeric metal complex cations.
The effect of high doses of remifentanil in brain near-infrared spectroscopy and in electroencephalographic parameters in pigs.

OBJECTIVE To study the effects of a high remifentanil bolus dose on pig's electroencephalographic indices and on brain regional and global oxygenation. STUDY DESIGN Prospective experimental study. ANIMALS Twelve healthy Large-White male pigs, age 3 months and weight 26.2 ± 3.6 kg. METHODS Anaesthesia was induced with intravenous propofol 4 mg kg⁻¹, then maintained with constant rate infusions of propofol (15 mg kg⁻¹ hour⁻¹) and remifentanil (0.3 μg kg⁻¹ minute⁻¹). Following instrumentation, all pigs received a 5 μg kg⁻¹ remifentanil bolus. The responses of jugular venous oxygen saturation, cardiac output and cerebral oxygen saturation to the remifentanil bolus were studied. The Bispectral index, spectral edge frequency 95%, total power, approximate entropy and permutation entropy were also studied. Repeated measures anova and Pearson correlation were used to analyze the effect of remifentanil bolus on these variables until 5 minutes after the bolus. RESULTS Cardiac output and cerebral oxygen saturation decreased significantly after the remifentanil bolus from 4.6 ± 0.9 to 3.8 ± 1.0 L minute⁻¹ and from 65 ± 6 to 62 ± 1% (p < 0.05), respectively. No significant changes were observed in the jugular venous oxygen saturation (p > 0.05) nor in any of the electroencephalogram derived indices (p > 0.05). Correlation analysis revealed strong positive significant correlations between cerebral oxygen saturation and cardiac output (r = 0.82, p < 0.001) and between cerebral oxygen saturation and approximate entropy (r = 0.65, p < 0.001). CONCLUSIONS AND CLINICAL RELEVANCE The effect caused by the remifentanil bolus on the brain oxygenation seems to be better reflected by the cerebral oxygen saturation than the jugular venous oxygen saturation. The effect of remifentanil on the electroencephalogram may not be reflected in indices derived from the electroencephalogram, but the potential of the approximate entropy in reflecting changes caused by opioids on the electroencephalogram should be further investigated.
Perceived Control Mediates the Relations between Depressive Symptoms and Academic Achievement in Adolescence

Abstract The present research examined the protective role played by perceived control in the relation between depressive symptoms and academic achievement in adolescence. A sample of 218 adolescents aged 11 to 16 filled in questionnaires to assess self-reported depressive symptoms and three factors tied with Perceived Control (PC): self-regulated learning strategies use, effort attribution, and perceived competence. Grade Point Average (GPA) was considered as a measure of academic achievement. A path model showed that the relation between GPA and depressive symptoms is mediated by PC (p<.05), and became non-significant when PC is considered. The discussion stresses the need to take into account the strategic and motivational factors favouring learning in planning programmes to prevent and treat depressive symptoms in adolescence.
{[SmCl(en)4][In2Te4]}n: an indium telluride with a one-dimensional sinusoidal chain.

The title compound, catena-poly[[chloridotetrakis(ethylenediamine-kappa(2)N,N')samarium(III)] [indium(III)-di-mu-tellurido-indium(III)-di-mu-tellurido]], {[SmCl(C(2)H(8)N(2))(4)][In(2)Te(4)]}(n), consists of a one-dimensional sinusoidal {[InTe(2)](-)}(n) anionic chain and [SmCl(en)(4)](2+) cations (en is ethylenediamine). The only other previously reported lanthanide analogue, viz. [LaCl(en)(4)][In(2)Te(4)], contains more usual linear one-dimensional {[InTe(2)](-)}(n) anion chains [Chen, Li, Chen & Proserpio (1998). Inorg. Chim. Acta, 273, 255-258]. The one-dimensional polymeric {[InTe(2)](-)}(n) chain is built of InTe(4) tetrahedra sharing opposite edges. The Sm(III) ion in the [SmCl(en)(4)](2+) cation is nine-coordinated by eight N atoms from four bidentate en molecules and by one chloride ion to form a monocapped square-antiprismatic geometry. The presence or absence of N-H.Cl hydrogen bonding is shown to affect the conformation of the anion.
catena-Poly[[dichloridomercury(II)]-micro-1-(2-pyridylmethyl)-1H-benzotriazole]: the effect of different metal centers on the self-assembly of coordination complexes.

To further investigate the relationship between the structures of benzotriazol-1-yl-based pyridyl ligands and their complexes, a new linear one-dimensional Hg(II) coordination polymer, [HgCl(2)(C(12)H(10)N(4))](n), with the 1-(2-pyridylmethyl)-1H-benzotriazole (L) ligand was obtained through the reaction of L with HgCl(2). In this complex, each Hg(II) center within the one-dimensional chain is coordinated by two chloride anions as well as by one pyridine and one benzotriazole N-atom donor of two distinct L ligands in a distorted tetrahedral geometry, forming a linear one-dimensional chain running along the [010] direction. Weak C-H.pi and pi-pi stacking interactions link the one-dimensional motifs to generate an overall two-dimensional network parallel to the (100) plane. Comparison of the structural differences with previous findings suggests that the presence of different metal centers may plays an important role in the construction of such supramolecular frameworks.
[Ability of smell after medialization of the middle nasal turbinate in endoscopic sinus surgery].

BACKGROUND Endoscopic sinus surgery usually requires a move of the middle nasal turbinate into the midline to achieve a better sight into the ethmoidal sinuses. In this procedure damages of the turbinate are possible, which later can lead to a scarred fixation of the turbinate. Fixing of the turbinate to the septum can avoid this effect, but could reduce smell ability by blocking of the upper nasal duct. MATERIAL In a prospective study with 83 patients with chronic sinusitis (55% CRS with polyps, 45% CRS without polyps) at the end of the operation the middle nasal turbinates were fixed at the nasal septum with a 4 × 0 stitch. Before the operation and 6 weeks, 3 and 5 months after operation the smell was tested using the "sniffin'sticks" threshold test. RESULTS After operation the ethmoidal area remained open without developing of relevant synechiae or scars. The smell ability decreased after surgery due to the obstruction of the upper nasal duct, but improved again later. After 5 months the average threshold of smell was better than before operation. Testing of the threshold values with the t-test showed a significant difference (p<0.001) between the pre- and postoperative status. CONCLUSION The method of medialization and temporary septal fixation of the middle nasal turbinate allows a sufficient ventilation and drainage of the paranasal sinuses after sinus surgery. Due to only temporary fixation of the turbinate at the septum, a permanent obstruction of the upper nasal duct and the olfactory area is prevented. Thus the threshold of smell is not reduced.
Granular clustering of de novo protein models

Motivation: Modern algorithms for de novo prediction of protein structures typically output multiple full‐length models (decoys) rather than a single solution. Subsequent clustering of such decoys is used both to gauge the success of the modelling and to decide on the most native‐like conformation. At the same time, partial protein models are sufficient for some applications such as crystallographic phasing by molecular replacement (MR) in particular, provided these models represent a certain part of the target structure with reasonable accuracy. Results: Here we propose a novel clustering algorithm that natively operates in the space of partial models through an approach known as granular clustering (GC). The algorithm is based on growing local similarities found in a pool of initial decoys. We demonstrate that the resulting clusters of partial models provide a substantially more accurate structural detail on the target protein than those obtained upon a global alignment of decoys. As the result, the partial models output by our GC algorithm are also much more effective towards the MR procedure, compared to the models produced by existing software. Availability and Implementation: The source code is freely available at https://github.com/biocryst/gc Contact: sergei.strelkov@kuleuven.be Supplementary information: Supplementary data are available at Bioinformatics online.
Project Head Start: A Legacy of the War on Poverty,

In recent years, it has seemed that we Americans are so given to self-flagellation that we cannot stand up and applaud anything. There were some victories scored in Lyndon Johnson's war on poverty, but none greater than Project Head Start. As the book jacket states: When Project Head Start was organized in 1965, its goals mirrored the hopes of millions of impoverished Americans. Initially funded as a short-term effort, Head Start has become, after more than a decade of operation and a cost of approximately $2 billion, the most ambitious educational, social and health program for young children and their families in United States history. This book, edited by Edward Zigler and Jeanette Valentine, examines the experience through the eyes of 35 authors from many disciplines. Most of them had a hand in Head Start. As with most multiauthored volumes, there is much repetition. Tight editing is not in evidence.
Hexane-1,6-diaminium chloride [hydrogen bis(chloroacetate)].

In the structure of the title compound, C(6)H(18)N(2)(2+). H(C(2)H(2)ClO(2))(2)(-). Cl(-), the hexane-1,6-diaminium dication is disordered over two sets of positions, with almost equal occupancies. Both alternative positions of the dication are in the fully extended conformation, situated on an inversion centre at (3/4, 1/4, 1/2). Two chloroacetic acid moieties, related by another centre of symmetry at (1/2, 1/2, 1/2), are connected by a very short symmetrical O.H.O hydrogen bond [O.O = 2.452 (2) A], with the H atom at the centre of inversion. These two fragments thus effectively form the hydrogen bis(chloroacetate) monoanion, and the overall charge is balanced by an additional chloride anion which resides on a twofold axis. The ions form a layer structure, with alternating layers of dications and anions running along the [101] direction, linked via hydrogen bonds. There are two N-H.O interactions and two N-H.Cl(-) interactions.
Titanium complexes with sulfur-linked bis(phenolate) ligands.

High-quality crystals of two bis(phenolate)titanium complexes, namely dichlorido{4,4'-dimethyl-2,2'-[cyclohexane-1,2-diylbis(sulfanediyl)]diphenolato}titanium(IV), [Ti(C(20)H(22)O(2)S(2))Cl(2)], (I), and dichlorido{2,2'-[cyclohexane-1,2-diylbis(sulfanediyl)]diphenolato}titanium(IV), [Ti(C(18)H(18)O(2)S(2))Cl(2)], (II), were obtained by reactive crystallization. Depending on the solvent, compound (II) was obtained as unsolvated (IIa) or as the toluene hemisolvate, [Ti(C(18)H(18)O(2)S(2))Cl(2)]. 0.5C(7)H(8), (IIb). These systems without bulky substituents on the aromatic phenolate rings serve as ideal model compounds for precatalysts. The excellent X-ray diffraction data will help clarify the nature of the mismatched interactions between the soft S atoms within the ligand and the hard titanium center. Molecule (I) has crystallographic C(2) symmetry.
Polymorphism in 2-(4-hydroxy-2,6-dimethylanilino)-5,6-dihydro-4H-1,3-thiazin-3-ium chloride.

Details of the structures of two conformational polymorphs of the title compound, C(12)H(17)N(2)OS(+)·Cl(-), are reported. In form (I) (space group P-1), the two N-H groups of the cation are in a trans conformation, while in form (II) (space group P2(1)/c), they are in a cis arrangement. This results in different packing and hydrogen-bond arrangements in the two forms, both of which have extended chains lying along the a direction. In form (I), these chains are composed of centrosymmetric R(4)(2)(18) (N-H.Cl and O-H.Cl) hydrogen-bonded rings and R(2)(2)(18) (N-H.O) hydrogen-bonded rings. In form (II), the chains are formed by centrosymmetric R(4)(2)(18) (N-H.Cl and O-H.Cl) hydrogen-bonded rings and by R(4)(2)(12) (N-H.Cl) hydrogen-bonded rings.
ClusterSignificance: a bioconductor package facilitating statistical analysis of class cluster separations in dimensionality reduced data

Summary: Multi‐dimensional data generated via high‐throughput experiments is increasingly used in conjunction with dimensionality reduction methods to ascertain if resulting separations of the data correspond with known classes. This is particularly useful to determine if a subset of the variables, e.g. genes in a specific pathway, alone can separate samples into these established classes. Despite this, the evaluation of class separations is often subjective and performed via visualization. Here we present the ClusterSignificance package; a set of tools designed to assess the statistical significance of class separations downstream of dimensionality reduction algorithms. In addition, we demonstrate the design and utility of the ClusterSignificance package and utilize it to determine the importance of long non‐coding RNA expression in the identity of multiple hematological malignancies. Availability and implementation: ClusterSignificance is an R package available via Bioconductor (https://bioconductor.org/packages/ClusterSignificance) under GPL‐3. Contact: dan.grander@ki.se Supplementary information: Supplementary data are available at Bioinformatics online.
Echocardiographic Assessment of Right Ventricular Function Before and After Surgery in Patients with Pectus Excavatum and Right Ventricular Compression

Abstract Background We aimed to evaluate the effect of surgical repair on right ventricular (RV) function in patients with pectus excavatum (PE) and RV compression by Doppler echocardiography. Materials and Methods Twenty-three patients who were admitted to our hospital for surgical correction of PE between 2009 and 2012 were included in the study. After transthoracic echocardiographic evaluation, 16 patients with RV compression were enrolled. All patients were males (100%) with a mean age of 20.5 ± 5.6 years. Transthoracic echocardiography was repeated 1 month after surgery. Echocardiographic evaluation included the assessment of RV diastolic diameter, tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler systolic velocity (S′), RV isovolumic acceleration (RV IVA), systolic pulmonary artery pressure, left ventricular (LV) ejection fraction, and myocardial performance indexes of both the right and the left ventricles (Tei index). Results Following the surgery, the RV end-diastolic diameter, TAPSE, S′, and RV IVA were found to be significantly increased in patients with PE. In addition, RV and LV Tei index significantly improved after surgical correction. Conclusions RV function significantly improved after corrective surgery. Quantitative echocardiographic examination provides accurate estimation when deciding for corrective surgery and also should be used in the assessment of postoperative improvement.
Absolute configuration of strictosidinic acid.

The absolute configuration of strictosidinic acid, (2S,3R,4S)-3-ethenyl-2-(β-D-glucopyranosyloxy)-4-{[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl}-3,4-dihydro-2H-pyran-5-carboxylate, was determined from its sodium chloride trihydrate, poly[[diaqua((2S,3R,4S)-3-ethenyl-2-(β-D-glucopyranosyloxy)-4-{[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-yl]methyl}-3,4-dihydro-2H-pyran-5-carboxylate)sodium] chloride monohydrate], {[Na(C(26)H(32)N(2)O(9))(H(2)O)(2)]Cl·H(2)O}(n). The strictosidinic acid molecule participates in intermolecular hydrogen bonds of the O-H.O and O-H.Cl types. The solid-state conformation was observed as a zwitterion, based on a charged pyridine N atom and a carboxylate group, the latter mediating the packing through coordination with the sodium cation.
Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome†

Abstract The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond appropriately to the conceptus by examining endometrial gene expression on day 19 of pregnancy. Immediately after calving, primiparous Holstein cows with similar production and fertility estimated breeding values were randomly divided into two groups and either dried off (i.e. never milked) immediately or milked twice daily. Approximately 65–75 days postpartum, grade 1 blastocysts recovered from superovulated Holstein heifer donors (n = 5) were transferred (1 per recipient) into lactating (n = 11) and nonlactating (n = 11) recipients. Control nulliparous Holstein heifers (n = 6) were artificially inseminated. RNAsequencing was performed on intercaruncular endometrial samples recovered at slaughter from confirmed pregnant animals on day 19 (n = 5 lactating and nonlactating cows; n = 4 heifers). Differentially expressed genes (DEGs) were identified between both postpartum groups compared to heifers and between lactating and nonlactating cows. Functional annotation of DEGs between cows and heifers revealed over-representation of categories, including endosome, cytoplasmic vesicle, endocytosis, regulation of exocytosis, and cytokine receptor activity. Functional categories including transcription factor binding sites, cell motility, and cell migration were enriched for DEGs between endometria from lactating and nonlactating cows. In conclusion, while the evidence for a major effect of lactation on the endometrial transcriptome is relatively weak, these data suggest that the metabolic status of the animal (heifer vs cow) modulates the response of the endometrium to the developing conceptus. Summary Sentence The endometrial response to a high quality embryo following transfer is minimal in lactating dairy rows compared to non-lactating cows but differs in its response to a conceptus in lactating cows compared to heifers.
Comparative transcriptomic analysis of human placentae at term and preterm delivery

Abstract Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are few predictive markers and few treatment options to prevent preterm birth. A healthy, functioning placenta is essential to positive pregnancy outcomes. Previous studies have suggested that placental pathology may play a role in preterm birth etiology. Therefore, we tested the hypothesis that preterm placentae may exhibit unique transcriptomic signatures compared to term samples reflective of their abnormal biology leading to this adverse outcome. We aggregated publicly available placental villous microarray data to generate a preterm and term sample dataset (n = 133, 55 preterm placentae and 78 normal term placentae). We identified differentially expressed genes using the linear regression for microarray (LIMMA) package and identified perturbations in known biological networks using Differential Rank Conservation (DIRAC). We identified 129 significantly differentially expressed genes between term and preterm placenta with 96 genes upregulated and 33 genes downregulated (P-value <0.05). Significant changes in gene expression in molecular networks related to Tumor Protein 53 and phosphatidylinositol signaling were identified using DIRAC. We have aggregated a uniformly normalized transcriptomic dataset and have identified novel and established genes and pathways associated with developmental regulation of the placenta and potential preterm birth pathology. These analyses provide a community resource to integrate with other high-dimensional datasets for additional insights in normal placental development and its disruption. Summary Sentence Distinct transcriptional profiles of spontaneous preterm birth placentae compared to term placentae identify gestational regulation or potential pathogenic mechanisms.