Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Epidermal Growth Factor, Glial Cell Line-Derived Neurotrophic and Leukemia Inhibitory Factor on the Proliferation and Differentiation Potential of Adipose Tissue-Derived Mesenchymal Stem Cells

Background: Thereisagreatdealof interestinusingadiposetissue-derivedmesenchymalstemcells(AT-MSCs)forclinicalapplica-tions. However,theimportantlimitationsof clinicalapplicationof stemcellsarethesmallnumberof cellsandtheirdiﬀerentiation into undesirable lineage in vitro. To overcome this problem, various growth factors are studied extensively. Objectives: Thecurrentstudyaimedatusing3diﬀerentdosesof epidermalgrowthfactor(EGF),glialcellline-derivedneurotrophic (GDNF),andleukemiainhibitoryfactor(LIF)tocultureAT-MSCsandevaluatingtheireﬀectsonproliferation,viability,diﬀerentiation potential, and maintenance of the stemness state of cells. Methods: The current experimental study was conducted on 8 - 10 male NMRI (Naval medical research institute) mice provided from research center and experimental animal house of Jundishapur University of Ahvaz, Iran, from September 2016 to April 2017. AT-MSCs were isolated from mice adipose tissue. The cells were cultured with three diﬀerent doses of EGF, LIF, and GDNF. The morphology and cell proliferation of the AT-MSCs were studied on the days 5, 7, and 11 by an inverted microscope and MTT assay, respectively. Toevaluatethestemnessstateof thecells, Oct4 expressionwasmeasuredusingquantitativereversetranscription-polymerase chain reaction (qRT-PCR). Also, diﬀerentiation potential of AT-MSCs toward adipogenic and osteogenic lineages was assessed. All tests were done in triplicate. Results: Proliferation and viability of the AT-MSCs cultured in 10 µ g/mL EGF, 5 µ g/mL LIF, 5 µ g/mL GDNF (b2 group) and 20 µ g/mL EGF, 5 µ g/mL LIF, 5 µ g/mL GDNF (b3 group) increased signiﬁcantly in the days 7 and 11 (170.27 (13.94), 174.39 (18.85) versus 100 (12.08) P < 0.001 (the day 7) and 152.45 (15.75) P < 0.001, 131.53 (19.17) versus 97.64 (13.43) P < 0.022 (the day 11). And diﬀerentiation potential of the cells was sustained, but Oct4 overexpressed in treatment groups on the days 7 and 11. Conclusions: EGF, LIF, and GDNF enhanced proliferation and viability of the AT-MSCs, but for clinical purposes, the growth factors should be applied cautiously.
Modelling the Food Availability and Environmental Impacts of a Shift Towards Consumption of Healthy Dietary Patterns in Australia

Dietary change has been suggested as a key strategy to maintain food security, improve health and reduce environmental impacts in the face of rising populations, resource scarcity and climate change impacts, particularly in developed countries. This paper presents findings from a quantitative modelling analysis of food availability and environmental implications of shifting the current average Australian dietary pattern to one of two alternative, healthy dietary patterns, the ‘healthy mixed diet’, with a mixture of animal and plant foods, and the ‘healthy plant-based diet’, with only plant foods. Both were constructed in accordance with the Australian Dietary Guideline recommendations, and four sustainability principles: Avoiding over-consumption, reducing intake of discretionary foods, reducing animal products, and reducing food waste. It was assumed that all food was provided domestically where possible, and export of foods only occurred when there was a surplus to domestic requirements. The authors compared the impacts of each dietary pattern on direct food availability, water use, land use, greenhouse gas emissions, fuel and energy use and fertiliser use. The plant-based diet had the best overall environmental and direct food availability outcomes, however had key vulnerabilities in terms of fertiliser and cropping land availability. For the agricultural sector overall, changes in diet had little effect on environmental impact due to the amount and nature of Australian exports, indicating that changes to production methods are also necessary. Likewise, changing diets had little effect on the existing environmentally intensive Australian economy, indicating that changes to other sectors are also necessary.
Platelet rich plasma in dermatology and cosmetology

Platelet rich plasma (PRP) therapies in medicine has become increasing popular during the last decade. The interest in in the application of PRP in dermatology and cosmetology has increased recently in different applications such as alopecia, skin rejuvenation, wound healing, scar revision, and tissue regeneration. PRP is an autologous blood product obtained from the blood of the patients. The detailed knowledge about PRP should help clinicians better understand this therapy. In this view, the current review was done for a better understanding of what pathologies can be corrected with PRP.
Anatomical traits of Cryptomeria japonica tree rings studied by wavelet convolutional neural network

Tree ring analysis is an important field of science, and is vital in modeling the environmental response system of tree growth. In most cases, analyses have been conducted using one parameter from one tree ring, e.g., ring-width, density, or ratio of stable isotopes. The information within a ring, however, has been less studied, although it offers many more possibilities for investigation, such as seasonal responses over shorter time scales. Therefore, to elucidate the sub-seasonal climatic response of softwood (Cryptomeria japonica), we investigate the use of a wavelet–convolutional neural network (CNN) model, which incorporates spectral information that is normally lost in conventional CNN models. This paper highlights the usefulness of the wavelet-CNN for classifying cross-sectional optical micrographs and extracting structural information specific to a calendar year. Class activation maps indicate that the dimension and position of cells in a radial file are likely to be discriminative features for the wavelet-CNN. This study shows that wavelet-CNNs have the potential to be highly effective methods for dendrochronology.
Impact of Microcredit on Living Standard of Dairy Entrepreneurs: Special Focus on Oddusuddan DS Division in Mullaitivu District

Microcredit is part of micro finance, which provides a wider range of financial services for low income people. Micro credit serves as a vital role for Living standard of poor people in the developing countries as well as in Sri Lanka. In this Study Oddusuddan DS division in Mullaitivu district was selected as research area. After the 30 years conflict situation most people in the Oddusuddan area in Mullaitivu district are subordinate to the poverty line, because most of the displaced people who are female other than male staying here. Women lost their male relatives in struggle, and forced to take a responsibility of their family in order to look after their children, aged parents and their male relatives. Micro credit helps the poor people particularly women in effective ways in order to create income generating activities. The prime objective of this study is to investigate the impact of Microcredit on living standard of dairy entrepreneurs in Oddusuddan DS division in Mullaitivu District. In the rural areas of Mullaitivu, Oddusuddan Divisional Secretariat Divisions 100 dairy entrepreneurs were selected as the sample size of population. The selected entrepreneurs who have received loan from samurdhi bank for dairy farming activities in Oddusuddan DS Division. Primary data were used for gathering information and quantitative analysis was carried out to find out the results. In the quantitative analysis the correlation and regression methods were employed to examine the hypotheses by using SPSS. The result of this study concluded that there is a positive impact of samurdhi micro credit on living standard of dairy entrepreneurs in Oddusuddan DS Division. In addition to this, using micro credit facilities create more job opportunities and variety of economic activities and improve household education, income, saving and heath condition of the people. The study recommends that micro credit institution should consider improve the living standard of dairy entrepreneurs through increase the loan amount with lower interest rate.
Multiscale relationships between stream temperature and juvenile recruitment in an imperilled freshwater fish

The distribution and population structure of organisms is governed by a broad suite of biotic and abiotic variables, interacting across multiple scales. Recruitment is a key demographic process critical to the maintenance of successful populations. Isolating and quantifying the multiscale environmental drivers of recruitment is vital for species conservation, especially for those species with traits that increase their susceptibility to local extirpation. We developed a Bayesian hierarchical model to quantify the relationship between the rate of recruitment in a locally threatened river blackfish (Gadopsis marmoratus) and environmental predictors across two spatial scales. There was a 0.99 probability that increased broad-scale stream temperature negatively affected juvenile recruitment rate. We also found that there was a 0.97 probability that the fine-scale relationship between recruitment rate and riparian foliage cover was dependent on temperature. This suggests that broad-scale thermal conditions provide the template upon which at least one local environmental variable influences recruitment rate. Understanding drivers influencing key population processes and the spatial scales at which they operate is critical to gaining an insight into likely changes in population persistence for potentially imperilled species, along with the potential future effects of habitat degradation and climate warming on freshwater fishes in general.
Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

Overnutrition and obesity promote adipose tissue dysfunction, often leading to systemic insulin resistance. The thiazolidinediones (TZDs) are a potent class of insulin-sensitizing drugs and ligands of PPARγ that improve insulin sensitivity, but their use is limited due to significant side effects. Recently, we demonstrated a mechanism by which TZDs improve insulin sensitivity distinct from receptor agonism and adipogenesis: reversal of obesity-linked phosphorylation of PPARγ at Serine 273. However, the role of this modification has not been tested genetically. Here we demonstrate that mice encoding an allele of PPARγ which cannot be phosphorylated at S273 are protected from insulin resistance, without exhibiting differences in body weight or TZD-associated side effects. Indeed, hyperinsulinemic-euglycemic clamp experiments confirm improved insulin sensitivity, as evidenced by increased whole-body glucose uptake. RNA-seq experiments reveal PPARγ S273 phosphorylation specifically enhances transcription of Gdf3, a BMP family member. Ectopic expression of Gdf3 is sufficient to induce insulin resistance in lean, healthy mice. We find that Gdf3 can impact metabolism by inhibition of BMP signaling. Together, these results highlight the diabetogenic role of PPARγ S273 phosphorylation and focuses attention on a putative target, Gdf3.
The application of cloud network English teaching based on virtual machine technology

With the development of computer technology, the research and practice of computer virtual machine technology in English teaching is gradually expanding, involving the production and use of teaching courseware, the use of teaching software, the use of computer network classroom, campus network, Internet and the practicability of distance learning. These studies and practices show the future development trend of foreign language teaching. This paper focuses on the popularization of cloud computing and virtual machine teaching. By introducing VMware virtualization technology to solve the problems encountered in the process of cloud computing teaching, it fully demonstrates the extensive application of virtualization technology and its irreplaceable role.
Metabolic Syndrome, Exercise, and Cardiovascular Fitness in Breast Cancer Survivors

Comorbid illness contributes to poorer cancer outcomes and higher mortality. Metabolic syndrome (MetS) includes a cluster of risk factors that are associated with an increased risk of comorbidities. Routine physical activity represents a risk reduction strategy for cancer survivors. From 148 participants in a 12-month randomized control trial (RCT) of a fitness center exercise intervention compared to home physical activity group, a subset analysis was conducted to explore the effect of exercise on MetS risk factors. There were 32 (21.6%) breast cancer survivors who met the criteria for MetS at baseline. Over the 12 months, there were significantly fewer participants who met the criteria for MetS (p < .01), and there was significant improvement in individual risk factors, specifically fasting blood sugar (p = .01), and high-density lipoprotein (HDL; p = .02). Cardiovascular fitness was evaluated and greater heart recovery rate (HRR) was negatively associated with waist circumference, triglycerides, systolic blood pressure, fasting blood sugar, and MetS risk (p < .02) and positively associated with HDL (p = .03). Oncology advanced practitioners are uniquely qualified to integrate risk reduction into the management of at-risk oncology patients.
Evaluation of quality of life and visual acuity after posterior capsulotomy with
 neodymium: YAG laser in adults

Abstract Purpose: To determine the impact of neodymium:YAG (Nd:YAG) laser posterior capsulotomy on quality of life and visual acuity in adults. Methods: A prospective study that included patients over 65 years old with clinical indications for Nd: YAG laser capsulotomy. On the day of the procedure, corrected distance visual acuity tests, slit-lamp examination and posterior capsule opacification (PCO) photo documentation were performed, followed by application of the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). The PCO rate was evaluated with Evaluation of Posterior Capsule opacification (EPCO 2000) software. Four weeks after the posterior capsulotomy, corrected distance visual acuity was measured, and the NEI-VFQ-25 was applied again. Complications were also reported. Results : Sixty eyes from 45 patients were enrolled in the study. The mean age was 71.51 ± 6.38 years (65 to 93). Comparing the results before and after the Nd:YAG laser capsulotomy, there was a statistically significant improvement in quality of life according to the NEI-VFQ-25 (p<0.001) and in visual acuity (p=0.0). The mean score in NEI-VFQ-25 Questionnaire before capsulotomy was 62.07 ± 20.90 (16.81-95.90) and after was 83.95±19.49 (20.68 - 100.0). The mean CDVA before the procedure was 0.75 ± 0.35 LogMAR (0.1-1.3) and after was 0.21 ± 0.20 LogMAR (0.0-1.3). The mean PCO rate measured by the EPCO software was 0.688 ± 0.449. There was a positive correlation between the EPCO score and the total score of quality of life after Nd: YAG laser capsulotomy (r=0.845, p=0.00). Damage to intraocular lens was the only complication observed in six eyes (10%). Conclusion: Nd: YAG laser capsulotomy, in addition to improving visual acuity, is able to improve quality of life.
Groundwater Quality Determination for Drinking Purpose by Using Water Quality Index Technique: A Case Study of Gadap Town, Karachi, Pakistan

Present study is aimed at assessment of groundwater quality of Gadap Town for drinking purpose using water quality index (WQI) technique. Gadap is located in the outskirt of Karachi city and mainly influenced by the agriculture activities. Groundwater samples (n = 22) were collected mainly from boring wells and a few through tube wells from variable depths (100-600 feet). The analytical results of water reveal occurrence of very high TDS (range: 466-3810; mean: 1402) and hardness contents (range: 250-2800 mg/L). On the other hand, pH varies (range: 6.9-8.1; mean: 7.5) within WHO guidelines (6.5-8.5) with a few samples showing turbidity. About one third of total collected samples (n = 8) were analyzed for qualitative determination of microbial contamination which are found positive, except one sample, indicating the sewage mixing. Major chemistry of groundwater is also found disturbed in terms of high content of Na (mean: 219 mg/L), K (mean: 15 mg/L), Ca (mean: 144 mg/L) and Mg (mean: mg/L 137). Similarly, anions varied in the order of Cl > HCO3 > SO4 > NO3. Although some parameters show the bad quality of water but Water quality index (WQI) value (16.18) indicates that the groundwater quality is suitable for drinking purpose. It is inferred from the present study that water quality is partly polluted due to anthropogenic activities mainly by sewage infiltration.
Financially Constrained Strategic Arbitrage

We develop an equilibrium model of strategic trading under nancial constraints. Investors have access to a fundamentally riskless arbitrage opportunity, but may be forced to re-sell if their capital does not fully cover their losses. Investors internalize both their price impact and the e¤ect of price movements on the constraints of all market participants, giving rise to a strategic motive for the less exposed investors to induce re-sales of more exposed ones. Ex ante, the presence of predatory risk leads to lower investment by all traders. We show the implications of strategic trading on price dynamics, returns characteristics, and leverage cross-section and dynamics. Keywords: limits to arbitrage, liquidity, wealth e¤ects, strategic trading, endogenous risk JEL Classi cation: C72, D43, G10 Preliminary version. We thank Christian Hellwig, Pete Kyle, Péter Kondor, Lasse Pedersen, Adam Reed, Rohit Rahi, Alp Simsek, Dimitri Vayanos, Andrea Vedolin, Kathy Yuan, and seminar participants at CBS, IE-HAS, and LSE for helpful comments. Emails: aytek.malkhozov@frb.gov, gv. @cbs.dk.
Tracing the Origin of Information Seeking Behavior by Reference Publication Year Spectroscopy (RPYS): Scientific Publication Based on ISC Database

This paper aims to introduce the quantitative method named Reference Publication Year Spectroscopy (RPYS). With this method one can determine the historical roots of research fields and quantify their impact on current research. Using a quantitative method named reference publication year spectroscopy (RPYS), this research tried to determine the historical roots of information seeking behavior research. RPYS pave the way for determining the significant years and works in information seeking behavior. The main problem is it can reveal whether Information Seeking Behavior has the same or different impact on these journals in terms of citation. Using scientometrics method, the initial data of this study have been extracted based on ISC Database. The revised data were analyzed and visualized in Excel. The distribution of cited references in information seeking behavior revealed four peaks within 20th century. Moreover, our analysis identified 4 peaks between 1989 and 2000 in the field of information seeking behavior, occurred respectively in 1989, 1993, 1998, and 2000. Based on the study findings, it seems that information seeking behavior research has been shaped intellectually by fields such as library and information science, management, etc. Moreover, it has been influenced by some theories and theoretical works
A Comparison among Reinforcement Learning Algorithms in Financial Trading Systems

In this work we analyze and implement different Reinforcement Learning (RL) algorithms in financial trading system applications. RL-based algorithms applied to financial systems aim to find an optimal policy, that is an optimal mapping between the variables describing the state of the system and the actions available to an agent, by interacting with the system itself in order to maximize a cumulative return. In this contribution we compare the results obtained considering different on-policy (SARSA) and off-policy (Q-Learning, Greedy-GQ) RL algorithms applied to daily trading in the Italian stock market. We consider both computational issues related to the implementation of the algorithms, and issues originating from practical application to real stock markets, in an effort to improve previous results while keeping a simple and understandable structure of the used models.
Dynamics of Cucumber Green Mottle Mosaic Virus Accumulation and its Association to the Disease Manifestation

The article presents data from laboratory experiment on the artificial infection of cucumber plants with the green mottle mosaic virus in different concentrations. The dynamics of virus accumulation in each of the experimental groups is described. There is an association for which stage of viral load that correlates with the onset of visible signs of infection and a further increase of the disease symptoms. The obtained data showed that the virus accumulation in the plant obeys the exponential equation. When constructing a graph of the accumulation of viral load, it was noted that the onset of visible manifestations of the disease falls on the linear segment of the curve, and the mosaic manifestation on the exponential segment. The dependence of daily average growth on the virus concentration has not been established. Based on the results of the experiment, we can give reasonable recommendations on the use of quantitative PCR analysis in predicting outbreaks of viral infections in greenhouse complexes based on the viral load in the plant during disease symptoms absence. Keywords—СGMMV, cucumber diseases, cucumber viruses, protected ground, phytopathogens, viral load, epiphytotics.
Comparative evaluation of abdominal hysterectomy by ligasure and conventional method

Background: Hysterectomy is the 2 most common surgical procedure performed in women and is associated with various complications like any other major surgical procedure. The objectives and aims of this study was to compare the effects of ligasure and conventional clamping and suturing in abdominal hysterectomy. Methods: A randomized controlled trial was performed by randomizing the patients in 2 groups ligasure (A) and conventional hysterectomy (B). Operative time, no. of sutures, blood loss, hospital stay and cost factor to patient were studied as its main outcomes. A total of 100 patients were studied. Results: 66% of patients in group A had duration of surgery that was less than an hour in spite of associated comorbidities. More no (76%) of patients in Group A had significantly less blood loss (<50 ml) as compared to 60% of patients in Group B. Only one suture was used in 80% of patients in Group A while in group B all of the patients required more than one suture from stumps to vault. There by reducing the cost of surgery. Conclusion: Apparently ligasure group seems to have less time for surgery and less blood loss and more intraoperative and postoperative complications, but to prove one ligasure group superior or inferior over conventional method we need to have more studies. But yes, Ligasure group reduces the cost of surgery to patient by reducing suture consumption as compared to conventional group.
Diagnostic challenges associated with the first episode of idiopathic nephrotic syndrome in children

Elżbieta Kuźma-Mroczkowska, Agnieszka Such-Gruchot, Małgorzata Pańczyk-Tomaszewska © Pediatr Med Rodz 2017, 13 (2), p. 195–202 © Medical Communications Sp. z o.o. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND). Reproduction is permitted for personal, educational, non-commercial use, provided that the original article is in whole, unmodified, and properly cited. DOI: 10.15557/PiMR.2017. 0020 Received: 20.01. 2017 Accepted: 19.04. 2017 Published: 30.06. 2017 Elżbieta Kuźma-Mroczkowska, Agnieszka Such-Gruchot, Małgorzata Pańczyk-Tomaszewska