Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes

Background The proton-pump inhibitor (PPI) test has been proposed as a valuable tool for diagnosing gastroesophageal reflux disease in Western populations. Goals We aim to compare the diagnostic accuracy of the PPI test using rabeprazole and pantoprazole in a Chinese population with a higher prevalence of poor PPI metabolization. Study After diagnostic endoscopy, patients with gastroesophageal reflux disease symptoms were randomly assigned to a 2-week test with rabeprazole (20 mg b.i.d.) or pantoprazole (40 mg b.i.d.). Therapeutic response was assessed with a 5-grade daily record. Genotypes of cytochrome P450 (CYP) 2C19 polymorphism were determined. Results Of the 178 patients who completed the study, 92 (51.7%) had erosive esophagitis and 78 (48.3%) were endoscopy-negative reflux disease. On the basis of 50% reduction of symptoms, there was a nonsignificant difference of diagnostic performances between rabeprazole and pantoprazole. For the CYP2C19 genotypes, 138 (87.3%) were determined to be extensive metabolizers (EMs) and 20 (12.7%) were poor metabolizers (PMs). When comparing the EMs and PMs, the diagnostic specificity in the prediction of erosive esophagitis was higher in the EMs (57.6% vs. 20.0%, P=0.040), as was the accuracy (74.6% vs. 50.0%, P=0.023). There were no differences in the sensitivity, positive predictive value, or negative predictive value. Conclusions CYP2C19 genotypic polymorphism was related to a higher possibility of false-positive results for patients who metabolized PPI poorly. High-dose rabeprazole and pantoprazole showed a similar diagnostic performance.
A model to evaluate competence of medical doctors for invasive techniques at hospitals:-Evaluation system based on competence criteria for quality assurance-

Since invasive techniques affect the patient’s body, doctors have to acquire knowledge and skills to implement such invasive techniques safely. In addition, to assure quality in the implementation of invasive techniques, we need to assess doctors’ competence in relation to these techniques. The purpose of this study was to develop a model to evaluate competence of medical doctors for invasive techniques at hospitals. It is essential that such a model is equipped with functions, procedures, and tools that are based on the existing literature related to competence evaluation. In this study, we reconstructed competence evaluation items used in a previous study. Competence evaluation items should evaluate concisely, specify the knowledge and skills to be acquired, and be comprehensible for the evaluator. To fulfill these requirements, we introduced the concept of the PDCA-cycle in the evaluation items, and applied it to invasive techniques. Based on these evaluation items, we designed procedures and tools for the implementation and management of competence evaluation. The procedure comprises 11 steps that need to be implemented by doctors and secretaries. Finally, we tested the model by utilizing it for deriving competence evaluation criteria in nine invasive techniques in Hospital A.
GENE FLOW IN CHAMAECRISTA FASCICULATA (LEGUMINOSAE) II. GENE ESTABLISHMENT

The role of gene establishment in gene flow was investigated in a population of the annual legume Chamaecrista fasciculata by determining the effect of interparent distance on progeny fitness throughout the entire life history. A decelerating gain in progeny fitness with increasing interparent distance was observed. Selfed progeny suffered a 2‐fold fitness disadvantage compared to progeny derived from mating events between individuals in the same neighborhood. Progeny derived from within neighborhood crosses had lower fitness than progeny from crosses between neighborhoods. Coupling the effect of interparent distance on gene establishment with information on gene dispersal resulted in a considerable increase in estimated gene flow. However, gene flow was still limited, as the average neighborhood area corresponded to a circle with radius of approximately 3.0 m. Yearly fluctuations in population size and variation in reproductive output lowered the estimate of Ne below the census estimate to approximately 100 individuals. The role of a seed bank in increasing the estimate of Ne was found to be insignificant. It is likely that genetic drift plays a major role in determining the distribution of genetic variation in this population.
Shelf‐life extension of cultured milk products

Purpose – Shelf‐life of cultured milk products is longer than milk but it is still limited. Shelf‐life of cultured milk products could be enhanced by adopting various techniques. The purpose of this paper is to describe how the longer shelf‐life thus attained would extend the market reach and would be economically beneficial to both producers and consumers.Design/methodology/approach – Attempt has been made to enlighten the various techniques such as bacteriocin (nisin, MicrogardTM, natamycin, etc.), lactoperoxidase‐thiocyanate‐hydrogen peroxide system (LP‐system), high pressure treatment, post‐production heat‐treatment (thermization, microwave heating), ultra‐violet (UV) irradiation, carbonization, etc.Findings – Application of more than one bacteriocin may be advantageous to minimize the possibility of survival of microflora resistant to a particular bacteriocin. Pasteurization, being more detrimental to dietetic properties of cultured milk products than thermization, its application is not suggested as.
HETEROCHRONIC DEVELOPMENTAL PLASTICITY IN LARVAL SEA URCHINS AND ITS IMPLICATIONS FOR EVOLUTION OF NONFEEDING LARVAE

Preexisting developmental plasticity in feeding larvae may contribute to the evolutionary transition from development with a feeding larva to nonfeeding larval development. Differences in timing of development of larval and juvenile structures (heterochronic shifts) and differences in the size of the larval body (shifts in allocation) were produced in sea urchin larvae exposed to different amounts of food in the laboratory and in the field. The changes in larval form in response to food appear to be adaptive, with increased allocation of growth to the larval apparatus for catching food when food is scarce and earlier allocation to juvenile structures when food is abundant. This phenotypic plasticity among full siblings is similar in direction to the heterochronic evolutionary changes in species that have greater nutrient reserves within the ova and do not depend on particulate planktonic food. This similarity suggests that developmental plasticity that is adaptive for feeding larvae also contributes to correlated and adaptive evolutionary changes in the transition to nonfeeding larval development. If endogenous food supplies have the same effect on morphogenesis as exogenous food supplies, then changes in genes that act during oogenesis to affect nutrient stores may be sufficient to produce correlated adaptive changes in larval development.
Perceived discrimination and depressive symptoms among US Latinos: the modifying role of educational attainment

ABSTRACT Objective: Despite growing evidence that discrimination may contribute to poor mental health, few studies have assessed this association among US Latinos. Furthermore, the interaction between discrimination and educational attainment in shaping Latino mental health is virtually unexplored. This study aims to examine the association between perceived discrimination and depressive symptoms and the modifying role of education among a population of Mexican-origin adults. Design: We utilized population-based data from 629 Mexican-origin adults (mean age = 52.8 years) participating the Niños Lifestyle and Diabetes Study (2013–2014). Perceived discrimination was defined as responding ‘sometimes’ or ‘often’ to at least one item on the 9-item Everyday Discrimination Scale. High depressive symptoms were defined as scoring ≥10 on the CESD-10. We used log-binomial and linear-binomial models to estimate prevalence ratios (PR) and prevalence differences (PD), respectively, of high depressive symptoms for levels of perceived discrimination. Final models were adjusted for age, sex, education, cultural orientation, and nativity. General estimating equations were employed to account for within-family clustering. Results: Prevalence of perceived discrimination and high depressive symptoms were 49.5% and 29.2%, respectively. Participants experiencing discrimination had higher depressive symptom prevalence than those never or rarely experiencing discrimination [PR = 1.94, 95% confidence interval (CI): 1.46–2.58; PD = 0.19, 95% CI: 0.12–0.27]. The strength of this association varied by education level. The association between discrimination and depressive symptoms was stronger among those with >12 years of education (PR = 2.69; PD = 0.24) compared to those with ≤12 years of education (PR = 1.36; PD = 0.09). Conclusion: US Latinos suffer a high burden of depressive symptoms, and discrimination may be an important driver of this burden. Our results suggest that effortful coping strategies, such as achieving high education despite high perceived discrimination, may magnify discrimination’s adverse effect on Latino mental health.
MEASURING EVOLUTIONARY CONSTRAINTS: A MARKOV MODEL FOR PHYLOGENETIC TRANSITIONS AMONG SEED DISPERSAL SYNDROMES

I introduce a Markov probabilistic model of transitions among discrete morphological states as a method for describing and testing nonrandom patterns of evolutionary change. The Markov model assumes one‐generational dependency, i.e., that the future direction of evolutionary change depends on the current morphology of a species, not on any history of changes. This model is very flexible, allowing for any number of discrete states to describe morphology, yet permit rigorous testing of even complex evolutionary hypotheses. I apply this model to changes in seed dispersal mechanisms within 571 genera of Neotropical plants, using cladistic methods to infer the ancestral and derived states within each genus. I then test a series of progressively more complex hypotheses about the constraints that might shape the patterns of observed evolutionary transitions: 1) no transition constraints; 2) all dispersal mechanisms are equally labile evolutionarily; 3) the probability of particular evolutionary transitions among dispersal mechanisms depends on the descendant state but not on the ancestral state; 4) transition probabilities differ among pairs of dispersal mechanisms, but are reciprocal within such pairs. More complex hypotheses matched the data significantly better than did simpler hypotheses. However, only one of the hypotheses (reciprocal transitions) fit the observed data and then only for the most cautious interpretation of the frequencies of transitions within genera. These results suggest that evolutionary transitions among major adaptive syndromes are indeed ordered, and the observed patterns of transitions suggest possible reasons for such macroevolutionary structure.
THE MIXED‐MODEL ANALYSIS OF VARIANCE APPLIED TO QUANTITATIVE GENETICS: BIOLOGICAL MEANING OF THE PARAMETERS

The mixed‐model factorial analysis of variance has been used in many recent studies in evolutionary quantitative genetics. Two competing formulations of the mixed‐model ANOVA are commonly used, the “Scheffe” model and the “SAS” model; these models differ in both their assumptions and in the way in which variance components due to the main effect of random factors are defined. The biological meanings of the two variance component definitions have often been unappreciated, however. A full understanding of these meanings leads to the conclusion that the mixed‐model ANOVA could have been used to much greater effect by many recent authors. The variance component due to the random main effect under the two‐way SAS model is the covariance in true means associated with a level of the random factor (e.g., families) across levels of the fixed factor (e.g., environments). Therefore the SAS model has a natural application for estimating the genetic correlation between a character expressed in different environments and testing whether it differs from zero. The variance component due to the random main effect under the two‐way Scheffe model is the variance in marginal means (i.e., means over levels of the fixed factor) among levels of the random factor. Therefore the Scheffe model has a natural application for estimating genetic variances and heritabilities in populations using a defined mixture of environments. Procedures and assumptions necessary for these applications of the models are discussed. While exact significance tests under the SAS model require balanced data and the assumptions that family effects are normally distributed with equal variances in the different environments, the model can be useful even when these conditions are not met (e.g., for providing an unbiased estimate of the across‐environment genetic covariance). Contrary to statements in a recent paper, exact significance tests regarding the variance in marginal means as well as unbiased estimates can be readily obtained from unbalanced designs with no restrictive assumptions about the distributions or variance‐covariance structure of family effects.
Interprofessional education in a student-led emergency department: A realist evaluation

ABSTRACT This article reports a realist evaluation undertaken to identify factors that facilitated or hindered the successful implementation of interprofessional clinical training for undergraduate students in an emergency department. A realist evaluation provides a framework for understanding how the context and underlying mechanisms affect the outcome patterns of an intervention. The researchers gathered both qualitative and quantitative data from internal documents, semi-structured interviews, observations, and questionnaires to study what worked, for whom, and under what circumstances in this specific interprofessional setting. The study participants were medical, nursing, and physiotherapy students, their supervisors, and two members of the emergency department’s management staff. The data analysis indicated that the emergency ward provided an excellent environment for interprofessional education (IPE), as attested by the students, supervisors, and the clinical managers. An essential prerequisite is that the students have obtained adequate skills to work independently. Exemplary conditions for IPE to work well in an emergency department demand the continuity of effective and encouraging supervision throughout the training period and supervisors who are knowledgeable about developing a team.
THE MEASUREMENT OF SELECTION ON QUANTITATIVE TRAITS: BIASES DUE TO ENVIRONMENTAL COVARIANCES BETWEEN TRAITS AND FITNESS

The use of regression techniques for estimating the direction and magnitude of selection from measurements on phenotypes has become widespread in field studies. A potential problem with these techniques is that environmental correlations between fitness and the traits examined may produce biased estimates of selection gradients. This report demonstrates that the phenotypic covariance between fitness and a trait, used as an estimate of the selection differential in estimating selection gradients, has two components: a component induced by selection itself and a component due to the effect of environmental factors on fitness. The second component is shown to be responsible for biases in estimates of selection gradients. The use of regressions involving genotypic and breeding values instead of phenotypic values can yield estimates of selection gradients that are not biased by environmental covariances. Statistical methods for estimating the coefficients of such regressions, and for testing for biases in regressions involving phenotypic values, are described.
Anxiety and post-traumatic stress disorder in cardiac patients

Research has established that anxiety and post-traumatic stress disorder (PTSD) are risk factors for the development of heart disease in healthy populations. In addition, anxiety and PTSD are associated with further morbidity in people with existing heart disease. This article considers whether anxiety and PTSD influence onset and recovery from heart disease. Clinical implications for health-care professionals are considered, including screening, treatment, and referral on to specialist services.
A feasibility study of a 2‐week self‐compassionate letter‐writing intervention for nontreatment seeking individuals with typical and atypical anorexia nervosa

OBJECTIVE Most individuals with anorexia nervosa (AN) do not seek treatment and shame is a common barrier. This study sought to determine whether a brief intervention designed to foster self-compassion would reduce shame and increase treatment motivation among nontreatment seeking individuals with AN. METHOD Forty nontreatment seeking females with AN (75%) and atypical AN were randomly assigned to 2 weeks of a daily self-compassionate letter-writing intervention or a waitlist control condition. All participants completed pre, mid, and post questionnaires, and were weighed pre and post. RESULTS The intervention yielded respectable credibility ratings and compliance and retained 95% of participants. Compared to the control condition, it produced greater increases in self-compassion and greater decreases in shame and fears of self-compassion. BMI and readiness to get help for one's eating decreased in the control condition but did not change significantly in the intervention condition, though the motivation for treatment showed a trend toward increasing. Changes in eating pathology and readiness to get help for one's weight did not differ between conditions. DISCUSSION Self-compassionate letter-writing may be an acceptable and feasible intervention for nontreatment seeking individuals with AN and might reduce certain barriers to help-seeking while improving psychological functioning.
INCREASED HERITABLE VARIATION FOLLOWING POPULATION BOTTLENECKS: THE ROLE OF DOMINANCE

Atlan, A. , D. Couvet, and P. H. Gouyon. 1992. Sex allocation in a hermaphroditic plant: Thymus vulgaris L. and the case ofgynodioecy. Journal ofEvolutionary Biology 5:189-203. Barton, N. H. 1990. Pleiotropic models of quantitative variation. Genetics 124:773-782. Bertin, C. , A. Panouille, and S. Rautou. 1976. Obtention de varietes de mais "prolifiques en epis" productives en grain et a large adaptation ecolegique. Agronomie 26:387-418. Camussi, A. 1979. Numerical taxonomy of Italian populations of maize based on quantitative traits. Maydica 24:161-174. Charlesworth, B. 1990. Optimization models, quantitative genetics, and mutation. Evolution 44:520538. Charnov, E. L. 1982. The theory of sex allocation. Princeton University Press, Princeton, N.J. Charnov, E. L. ,J. MaynardSmith,andJ.J. Bull. 1976. Why be an hermaphrodite? Nature 263:125-126. De Jong, G. 1993. Covariances between traits deriving from repeated allocations of a resource. Functional Ecology. 7:75-83. De Laguerie, P., 1. Olivieri, A. Atlan, and P. H. Gouyon. 1991. Analytic and simulation models predicting positive genetic correlations between traits linked by tradeoffs. Evolutionary Ecology 5:361369. Duncan, W. G. , W. A. Williams, and R. S. Loomis. 1967. Tassels and the productivity ofmaize. Crop Science 7:37-39.
CLINAL VARIATION IN EASTERN POPULATIONS OF THE WATERSTRIDER AQUARIUS REMIGIS: GRADUAL INTERGRADATION OR DISCONTINUITY?

1963. Animal species and evolution. Belknap, Cambridge, Mass. Mousseau, T. A. , and D. A. Rolf. 1987. Natural selection and the heritability of fitness components. Heredity 59:181-197. Mukai, T. 1985. Experimental verification ofthe neutral theory. Pp, 125-145 in T. Ohta and K-I. Aoki, eds. Population genetics and molecular evolution. Springer, Berlin. ---. 1988. Genotype-environment interaction in relation to the maintenance of genetic variability in populations ofDrosophila melanogaster. Pp, 2131 in B. S. Weir, E. J. Eisen, M. M. Goodman, and G. Namkoong, eds. Proceedings of the second international conference on quantitative genetics. Sinauer, Sunderland, Mass. Mukai, T. , R. K Cardellino, T. K Watanabe, and J. F. Crow. 1974. The genetic variance for viability and its components in a population of Drosophila melanogaster. Genetics 78:1195-1208. Robertson, A. 1952. The effect ofinbreeding on variation due to recessive genes. Genetics 37:189-207. Roff, D. A. , and T. A. Mousseau. 1987. Quantitative genetics and fitness: lessons from Drosophila. Heredity 58:103-118.
Translation and psychometric evaluation of the Swedish version of the Interdisciplinary Education Perception Scale

ABSTRACT Interprofessional education (IPE) is widely accepted worldwide, as a key part of training for health professionals and critical to an effective, patient-centred healthcare system. Several tools have been developed to evaluate IPE programmes and interventions globally. Many of the widely-used tools have been successfully adapted to suit specific cohorts and different languages; the Interdisciplinary Education Perception Scale (IEPS), however, has not yet been translated and validated for use in Sweden. The aim of this study was to translate the IEPS into Swedish and validate the psychometric properties of this new version. The 12-item IEPS underwent translation into Swedish and back-translation into English by suitable independent translators to ensure items retained their meaning. The new Swedish version was completed by 164 medical and nursing, occupational therapy and physiotherapy students on clinical placements in Stockholm. Principal Axis Factoring (PAF) and Oblique Oblimin Rotation confirmed a three-factor structure, that explained 77.4% of variance. The new 10-item Swedish version IEPS displayed good internal consistency with an overall Cronbach’s alpha of a = . 88 and subscale values of . 89, . 88 and . 66. The exclusion of two-items limits the transferability of this scale; however, the factor makeup was very similar to the original 12-item English version. It is suspected that minor differences were due to unavoidable deviations in meaning following translation (i.e. certain English words have no equivalent in Swedish). Nevertheless, the results imply that the Swedish version of the IEPS is a valid and reliable tool for assessing students’ perceptions and attitudes towards IPE within the Swedish health education system.
Intussusception:

Intussusception, the invagination of one portion of the intestine into another, is considered a true emergency, which most commonly affects pediatric patients. It occurs when bowel (small or large) telescopes within itself, creating an obstructive mass. Peristalsis exacerbates the more proximal bowel into the lesion, causing the intussusception to have a “sleeve”-like shape. The lesion propagates distally, with obstructive ischemia and possible necrosis occurring over time. With the improvement of technology in diagnostic imaging, sonography has become the initial imaging modality of choice. The authors present a case study and current review of the literature regarding intussusception from a sonographer's viewpoint.