Miracle-dz/UniFAR-FTUs huggingface dataset:
Dimensionality and reliability of the Depression Anxiety Stress Scales 21 among adolescents in North Macedonia

This study examined the structural validity and reliability of the DASS-21 in a large sample (N = 4,202) of secondary school students from North Macedonia (Mage = 16.43 ± 1.04, 65% girls). Based on theoretical and empirical considerations, five structural models were compared using confirmatory factor analysis. The original three-factor model provided good fit to the data; however, high interfactor correlations indicated that the depression, anxiety, and stress factors were indistinguishable. The bifactor solution yielded superior fit relative to other tested models. Factor loading patterns revealed a strong general factor and some specificity of the depression and anxiety factors, whereas the stress items were primarily markers of general distress. Model-based reliability and ancillary bifactor indices revealed that the DASS-21 is essentially unidimensional. Thus, only the total score could be used as a reliable measure of general emotional distress, while subscale scores should be avoided. Overall, the findings provide further support for the cross-cultural validity of the DASS-21 and confirm that it is suitable for use among older adolescents in North Macedonia.
Influence of distributive justice on organizational citizenship behaviors: The mediating role of gratitude

Distributive justice is known to have important emotional and affective outcomes. The present study explores the role of distributive justice as an antecedent to feelings of gratitude toward the organization. Borrowing from social exchange theory, we investigate the mediating role of gratitude in the relationship between “perceived fairness in distributive justice” and “employees’ organization citizenship behaviors (OCB). ” Time-lagged, multi-source data was collected from 185 employees and their supervisors employed in a large manufacturing organization based in East India. Two significant findings emerge. First, the results indicate that feelings of gratitude signal fair distribution of benefits such that the employees go beyond the call of the duty to invest in OCB. Second, engagement in such acts seems to nullify their social debts highlighted in the social exchange perspective. Thus, a strong moral emotion, gratitude is a powerful vehicle that drives employees to act in the organization’s interests because doing is desirable and rightful. Implications for theory and practice are discussed.
Background inhibited and speed-loss-free volumetric imaging in vivo based on structured-illumination Fourier light field microscopy

Benefiting from its advantages in fast volumetric imaging for recording biodynamics, Fourier light field microscopy (FLFM) has a wide range of applications in biomedical research, especially in neuroscience. However, the imaging quality of the FLFM is always deteriorated by both the out-of-focus background and the strong scattering in biological samples. Here we propose a structured-illumination and interleaved-reconstruction based Fourier light field microscopy (SI-FLFM), in which we can filter out the background fluorescence in FLFM without sacrificing imaging speed. We demonstrate the superiority of our SI-FLFM in high-speed, background-inhibited volumetric imaging of various biodynamics in larval zebrafish and mice in vivo. The signal-to-background ratio (SBR) is improved by tens of times. And the volumetric imaging speed can be up to 40 Hz, avoiding artifacts caused by temporal under-sampling in conventional structured illumination microscopy. These suggest that our SI-FLFM is suitable for applications of weak fluorescence signals but high imaging speed requirements.
Use of whole-cell bioreporters to assess bioavailability of contaminants in aquatic systems

Water contamination has become increasingly a critical global environmental issue that threatens human and ecosystems’ health. Monitoring and risk assessment of toxic pollutants in water bodies is essential to identifying water pollution treatment needs. Compared with the traditional monitoring approaches, environmental biosensing via whole-cell bioreporters (WCBs) has exhibited excellent capabilities for detecting bioavailability of multiple pollutants by providing a fast, simple, versatile and economical way for environmental risk assessment. The performance of WCBs is determined by its elements of construction, such as host strain, regulatory and reporter genes, as well as experimental conditions. Previously, numerous studies have focused on the design and construction of WCB rather than improving the detection process and commercialization of this technology. For investigators working in the environmental field, WCB can be used to detect pollutants is more important than how they are constructed. This work provides a review of the development of WCBs and a brief introduction to genetic construction strategies and aims to summarize key studies on the application of WCB technology in detection of water contaminants, including organic pollutants and heavy metals. In addition, the current status of commercialization of WCBs is highlighted.
Renal fat fraction is significantly associated with the risk of chronic kidney disease in patients with type 2 diabetes

Backgrounds Ectopic fat deposition is closely related to chronic kidney disease (CKD). Currently, there are few population studies that have been conducted to determine the relationship between renal parenchyma fat deposition and the risk of CKD among patients with type 2 diabetes mellitus (T2DM). Therefore, we employed magnetic resonance imaging (MRI) to detect renal parenchyma fat content in individuals with T2DM, expressed as renal fat fraction (FF), to explore whether renal FF is an important risk factor for CKD in patients with T2DM. Methods In this cross-sectional study, 189 subjects with T2DM were enrolled. CKD was defined as the estimated glomerular filtration rate (eGFR)<60 mL/min/1.73m2. Measurement of the renal FF was performed on a 3.0-T MRI (MAGNETOM Skyra, Siemens, Erlangen, Germany). Binary logistic regression was used to determine the association between tertiles of renal FF and risk of CKD. Receiver-operator characteristic (ROC) curves were constructed to evaluate the sensitivity and specificity of renal FF in detecting CKD in T2DM patients. Results The patients were divided into three groups according to tertiles of the renal FF level (2.498 - 7.434). As renal FF increases, patients tend to be older, and more abdominally obese, with a decreased eGFR (p<0.05). After adjustment for potential confounders, patients in the highest tertile of renal FF had a significantly increased risk of CKD than those in the lowest tertile (odds ratio (OR) = 3.98, 95% confidence interval (CI) = 1.12 - 14.09, p = 0.032), and the area under the ROC curve for this model was 0.836 (0.765–0.907). Conclusions The renal FF is significantly independently associated with CKD in patients with T2DM.
Somatic embryogenesis and plant regeneration from transverse thin cell layers of adult peach palm (Bactris gasipaes) lateral offshoots

In this work, we report a successful protocol to obtain in vitro peach palm (Bactris gasipaes Kunth) “Diamantes 10” plants through somatic embryogenesis from transverse thin cell layer (TCL) explants, dissected from three sections (basal, medial, and apical) of lateral offshoots of adult plants cultured on different concentrations of 4-amino-3,5,6-trichloropicolonic acid (picloram). After swelling and development of primary callus in all treatments, without any strong effect of explant origin or picloram concentration, it was possible to observe the formation of embryogenic structures and the exact point from where they developed. Browning was also observed and correlated to the induction treatments, although it was not an impairment for the production of embryogenic structures. Subsequent maturation and conversion of somatic embryos into plantlets allowed their acclimatization 17 months after culture initiation (ACI), which was quicker than previous reports with juvenile tissues (from embryos or seed-germinated plantlets). To the best of our knowledge, this is the first report on peach palm regeneration through somatic embryogenesis from TCL explants from adult plants and could constitute, after fine-tuning the acclimatization stage, a tool for mass clonal propagation of elite genotypes of this open-pollinated crop, as well as for the establishment of conservation strategies of in situ gene bank plant accessions endangered due to aging and other threats.
Multiscale hydro-mechanical analysis of unsaturated granular materials using bridging scale method

Purpose – The purpose of this paper is to extend the bridge scale method (BSM) developed for granular materials with only the solid phase to that taking into account the effects of wetting process in porous continuum. The granular material is modeled as partially saturated porous Cosserat continuum and discrete particle assembly in the coarse and fine scales, respectively. Design/methodology/approach – Based on the mass and momentum conservation laws for the three phases, i.e. the solid skeleton, the pore water and the pore air, the governing equations for the unsaturated porous Biot-Cosserat continuum model in the coarse scale are derived. In light of the passive air pressure assumption, a reduced finite element model for the model is proposed. According to the decoupling of the fine and coarse scale calculations in the BSM, the unsaturated porous Cosserat continuum model using the finite element method and the discrete element model using the discrete element method for granular media are combined. Find.
Branched-chain amino acids linked to depression in young adults

Depression is a heterogeneous mental health problem affecting millions worldwide, but a majority of individuals with depression do not experience relief from initial treatments. Therefore, we need to improve our understanding of the biology of depression. Metabolomic approaches, especially untargeted ones, can suggest new hypotheses for further exploring biological mechanisms. Using the FinnTwin12 cohort, a longitudinal Finnish population-based twin cohort, with data collected in adolescence and young adulthood including 725 blood plasma samples, we investigated associations between depression and 11 low–molecular weight metabolites (amino acids and ketone bodies). In linear regression models with the metabolite (measured at age 22) as the dependent variable and depression ratings (measured at age 12, 14, 17, or 22 from multiple raters) as independent variables [adjusted first for age, sex, body mass index (BMI), and additional covariates (later)], we initially identified a significant negative association of valine with depression. Upon further analyses, valine remained significantly negatively associated with depression cross-sectionally and over time [meta-analysis beta = −13.86, 95% CI (−18.48 to −9.25)]. Analyses of the other branched-chain amino acids showed a significant negative association of leucine with depression [meta-analysis beta = −9.24, 95% CI (−14.53 to −3.95)], while no association was observed between isoleucine and depression [meta-analysis beta = −0.95, 95% CI (−6.00 to 4.11)]. These exploratory epidemiologic findings support further investigations into the role of branched-chain amino acids in depression.
Would you believe an intoxicated witness? The impact of witness alcohol intoxication status on credibility judgments and suggestibility

Memory conformity may occur when a person’s belief in another’s memory report outweighs their belief in their own. Witnesses might be less likely to believe and therefore take on false information from intoxicated co-witnesses, due to the common belief that alcohol impairs memory performance. This paper presents an online study in which participants (n = 281) watched a video of a mock crime taking place outside a pub that included a witness either visibly consuming wine or a soft drink. Participants then read a statement from the witness that varied in the number of false details it contained before being asked to recall the crime. We found that the intoxicated witness was regarded as significantly less credible, but participants were not less likely to report misinformation from them. This suggests that intoxication status impacts one’s perception of how credible a source is, but not one’s ability to reject false suggestions from this source. Our findings reinforce the importance of minimizing co-witness discussion prior to interview, and not to assume that people automatically (correctly or not) discount information provided by intoxicated co-witnesses.
Differences in motor unit firing properties of the vastus lateralis muscle during postural and voluntary tasks

The firing properties of the motor units are usually affected by the motor task. However, it has not been clarified whether the firing properties of the motor units of a specific muscle are different between postural and voluntary tasks. Therefore, this study investigated whether the recruitment and rate coding of the motor units differ between these two motor tasks. Thirteen healthy volunteers performed trapezoidal muscle contraction with a target value of 15% maximum electromyography (EMG) activity by voluntary left knee extension in the sitting position (voluntary task) and postural maintenance in the semi-squatting position (postural task) with a knee flexion angle of 30°. We obtained four channels of surface EMG activity during each task from left vastus lateralis muscle. We extracted the firing properties of individual motor units using the EMG decomposition algorithm. The recruitment threshold and motor unit action potential amplitude were significantly lower in the postural task than in the voluntary task, and conversely, the mean firing rate was significantly higher. These results were explained by the preferential recruitment of motor units with higher recruitment threshold and amplitude in the voluntary task, while motor units with lower recruitment threshold and higher firing rate were preferentially recruited in the postural task. Preferential activation of fatigue-resistant motor units in the postural task is a reasonable strategy as it allows for sustained postural maintenance. We provide the first evidence that motor unit firing properties are clearly different between postural and voluntary tasks, even at the same muscle activity level.
Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy

Surgical treatment of pharmacoresistant temporal lobe epilepsy (TLE) carries risks for language function that can significantly affect the quality of life. Predicting the risks of decline in language functions before surgery is, consequently, just as important as predicting the chances of becoming seizure-free. The intracarotid amobarbital test, generally known as the Wada test (WT), has been traditionally used to determine language lateralization and to estimate their potential decline after surgery. However, the test is invasive and it does not localize the language functions. Therefore, other noninvasive methods have been proposed, of which functional magnetic resonance (fMRI) has the greatest potential. Functional MRI allows localization of language areas. It has good concordance with the WT for language lateralization, and it is of predictive value for postsurgical naming outcomes. Consequently, fMRI has progressively replaced WT for presurgical language evaluation. The objective of this manuscript is to review the most relevant aspects of language functions in TLE and the current role of fMRI and WT in the presurgical evaluation of language. First, we will provide context by revising the language network distribution and the effects of TLE on them. Then, we will assess the functional outcomes following various forms of TLE surgery and measures to reduce postoperative language decline. Finally, we will discuss the current indications for WT and fMRI and the potential usefulness of the resting-state fMRI technique.
Carrier-free supramolecular nanoassemblies of pure LSD1 inhibitor for effective anti-tumor therapy

The LSD1 protein is an oxidase that regulates protein methylation, which regulates gene expression and triggers tumors. Previously, inhibiting LSD1 has been found to be an effective treatment strategy for opposing tumors caused by overexpression of LSD1. Our recent study found that compound 17i was a suitable LSD1 inhibitor with potential anti-tumor activity. However, its extremely insoluble nature limits further validation of its anti-tumor activity at the clinical level. In this study, a unique carrier-free supramolecular nanoassemblies of pure compound 17i is expected to enhance therapeutic efficacy. Aqueous-insoluble compound 17i was mixed with a small quantity of DSPE-PEG2000 into an organic solvent and was prepared as nanoassemblies in water via the one-step nanoprecipitation method. The 17i nanoassemblies have a similar effect on its cytotoxicity when compared with 17i solution in vitro. Importantly, the PEGylated 17i nanoassemblies exhibit significant superiorities over 17i solutions in therapeutic efficiency, anti-tumor immune response and systemic toxicity in BALB/c mice bearing CT-26 colorectal tumors. We envision that the fabrication of pure drug nanoassemblies offers an efficient platform for reforming the undesirable characteristics of drug-like compounds to potentiate the anti-tumor therapeutic effect.
Influence of memorability on revisit intention in welcome back tourism: The mediating role of nostalgia and destination attachment

“Welcome Back Tourism” is an important marketing strategy to help overseas Tourism destinations quickly recover from the crisis and enhance their core competitiveness. How to translate the memorability of tourists to revisit intention is the core key to open “Welcome Back Tourism. ” This study takes local residents in Guangzhou, Shenzhen and Foshan as the research objects, and tries to explore the influence relationship between memorability of a previous travel experience, nostalgia, destination attachment and revisit intention. The results of 291 valid data showed that memorability of a previous travel experience had positive influence on revisit intention; Nostalgia has a positive effect on destination attachment. Nostalgia and destination attachment play a mediating role in the influence of memorability of a previous travel experience on revisit intention. The contributions and management Recommendations of these findings are discussed.
Enhancing Rubisco gene expression and metabolites accumulation for better plant growth in Ficus deltoidea under drought stress using hydrogen peroxide

Growth improvement of the medicinal plant, Ficus deltoidea (Mas Cotek) under drought conditions is a vital issue in Malaysia since it is a slow-growing plant and disposed to leaf damage under the stresses of drought. Therefore, investigation was done to examine the outcomes of hydrogen peroxide (H2O2) application on Rubisco gene expression and metabolites accumulation of stressed F. deltoidea plants, and thereby to record the changes in leaf histology, photosynthesis, biochemical properties, and the growth of the plant. H2O2 at the rates of 0, 5, 10, 15, and 20 mM were foliar sprayed biweekly on the drought stressed plants using a hand sprayer. The application of 20 mM H2O2 amplified leaf number, tallness, stomatal conductance, and photosynthetic yield by 143, 24, 88, and 18%, respectively, over the control plant. A reduced transpiration rate and improved chlorophyll fluorescence were also noted in H2O2-treated plants. The treatment produced a greater amount of chlorophyll a, total phenols, total flavonoids, sugar content, and antioxidant activities by 1.61-, 1.30-, 1.98-, 1.92-, and 1.53-fold, respectively. Application of 15 mM H2O2 enhanced net photosynthetic rate and internal CO2 concentrations by 1.05- and 1.25-fold, respectively. Additionally, H2O2 treatments promoted stomatal closure, increased stomata size, the number of stomata, improved vein structure, and reduced the damage of the leaf margin and mesophyll cells of drought stressed plants. The application of H2O2 also accumulated significantly higher contents of sodium (Na+), calcium (Ca2+), potassium (K+), magnesium (Mg+), and iron (Fe2+) in stressed plants. Although the amount of Arsenic (As+) and Antimony (Sb3+) increased to some extent, the increases were not at a toxic level. The use of H2O2 enhanced the Rubisco gene expression to a greater level and the ratio of Rubisco expression increased up to 16-fold. Finally, thirteen (13) identified and five (5) unmatched volatile compounds with a quality score above 70% were identified by gas chromatography-mass spectrometry (GCMS). The GCMS analysis showed that the foliar application of H2O2 accumulates a higher percentage of volatile components in plants which helps to mitigate the negative effects of drought stress. It is concluded that under drought stressed conditions the F. deltoidea plants should be treated with 10–15 mM of H2O2 twice a week to improve leaf histology, photosynthesis, the level of Rubisco gene expression and volatile compounds accumulation, and plant growth and development.
Intégration de connaissances syntaxiques et sémantiques dans les représentations vectorielles de textes

The notion of similarity between texts is fundamental for many applications of Natural Language Processing. For example, this notion is particularly useful for the applications designed for the management of information in large textual databases, such as Information Retrieval or Automatic Text Structuring. Information Retrieval is the search of the most relevant documents according to an information need expressed by a query, and can be implemented by the search of the documents most similar to the query. Automatic Text Structuring is often viewed as the clustering of documents according to their similarity measures. The similarity between documents relies on their representation. The most used textual representation is the Vector Space model, in which each document is represented by a vector, and the similarity between documents is then computed by a distance measure in this space, for instance, the cosine of the vectors representing the documents. We first present several vector space models used for the computation of similarities between documents. Then, we focus on the problem of the integration of additional knowledge in the vector space representation, and the impact of this integration on the results obtained for several tasks. We fist consider the integration of co-occurrences in the representation model, and we focus on the DSIR model (Distributional Semantics based In-formation Retrieval). We show that this model has a probabilistic theoretical basis. We then consider the use of syntactic information to compute the co-occurrence frequencies. We also consider the integration of knowledge about compounds in the representation, taking into account morpho-syntactic and semantic variants of the considered compounds. We finally address the issue of word sense disambiguation, using synonymy relations to derive a vector space representation for which each dimension is associated to a meaning and not to a term. For all these methods, we propose several evaluations : we first consider a validation for the notion of similarity derived from a vector space representation, in a multi-lingual framework : the idea is to verify that the similarity between two documents in one language is close to the similarity between their translations in another language. We also propose an evaluation of the different models considered in a standard Information Retrieval evaluation framework. We finally consider the evaluation of the models on a Word Sense Disambiguation task.