Miracle-dz/UniFAR-FTUs huggingface dataset:
Customer orientation as a development driver in manufacturing : the case of ‘ reverse ’ servitization

Across many industries, manufacturing companies are extending their product offerings with services. This phenomenon, also known as servitization, extends the reach of the manufacturer ever closer to the customer. Several researchers have argued that servitization is a unidirectional, stepwise process that starts from the adding of simple services to the total offering. However, our case studies indicate that there are more alternatives in the process of servitization than usually described in literature. In our in-depth case study, we focus on the issue whether the prevalence of one general process type, starting from simpler to more demanding services, can be questioned.
Lower-complexity Wiener filtering for UE-RS channel estimation in LTE DL system

Channel estimation algorithms play a key role in 3GPP Long Term Evolution (LTE) Downlink (DL) systems in facilitating coherent detection of data. In this paper, we report the performance of a new scheme for User Equipment-specific Reference Signals (UE-RS) channel estimation, which is 2 1- D Wiener filtering with linear interpolation as a less computationally complex scheme compared to 2-D Wiener filtering and interpolation. Simulations show that 2 1-D Wiener filtering with linear interpolation requires = 34% and = 2.6% of the number of computations needed by 2-D Wiener filtering with linear interpolation and Wiener interpolation, respectively. In addition, it was shown that 2 1-D Wiener filtering performance is sub-optimal when compared with the performance of 2-D Wiener filtering. Moreover, simulations indicate that the best noise reduction method is a combination of both averaging and Wiener filtering with linear interpolation, where the lower bound is a function of both SNR and the channel statistics.
ompH gene expression is regulated by multiple environmental cues in addition to high pressure in the deep-sea bacterium Photobacterium species strain SS9

Photobacterium species strain SS9 is a moderately barophilic (pressure-loving) deep-sea bacterial species which induces the expression of the ompH gene in response to elevated pressure. Here we demonstrate that at 1 atm (1 atm = 1.01325 x 10(5) Pa), ompH expression increases with cell density in 2216 marine medium batch culture and is subject to catabolite repression and the OmpH synthesis is inducible by energy (carbon) starvation. Regulatory mutants which are impaired in ompH gene expression at high pressure are also impaired in cell density regulation of ompH gene expression, indicating that the two inducing conditions overlap in their signal transduction pathways. The same promoter was activated by high cell density at 1 atm of pressure as well as during low-cell-density growth at 272 atm. Catabolite repression of ompH gene expression was induced by a variety of carbon sources, and this repression could be partially reversed in most cases by the addition of cyclic AMP (cAMP). Surprisingly, glucose repression of ompH transcription occurred only at 1 atm, not at 272 atm, despite the fact that catabolite repression was operational in SS9 under both conditions. It is suggested that ompH expression is cAMP and catabolite repressor protein dependent at 1 atm but becomes cAMP and perhaps catabolite repressor protein independent at 272 atm. Possible mechanisms of ompH gene activation are discussed.
Healthy women's PEF variations with ambient summer concentrations of PM10, PM2.5, SO42-, H+, and O3.

The relationship between ambient air pollution and daily change in peak expiratory flow (PEF) was studied in a sample of 473 nonsmoking women (age 19 to 43 yr) in Virginia over summers 1995- 1996. Daily 24-h averages of particulate matter (PM2.5 and PM10), fine particulate sulfate (SO42-) and strong acid (H+), hourly ozone (O3), and select meteorologic variables (e.g., temperature) were collected at a regional outdoor monitoring site. Subjects took PEF measurements twice daily for a 2-wk period using a standard MiniWright peak flow meter. Concurrent measures for summer periods of 24-h PM2.5 (micrograms/m3) ranged from 3.5 to 59.7; H+ (nmol/m3) from 0 to 250; maximal daily 8-h average O3 (ppb) from 17.0 to 87.6. Morning PEF decrements were significantly associated with H+ and PM2. 5. An increase of 50 etamol/m3 of H+ and 10 micrograms/m3 of PM2.5 related to decreases of 0.89 (95% CI = 0.21 to 1.57) and 0.73 (95% CI = 0.07 to 1.38) L/min in morning PEF, respectively. Ozone was the only exposure related to evening PEF with 5-d cumulative lag exposure showing the greatest effect; 7.65 L/ min (95% CI = 2.25 to 13.0) decrease per 30 ppb O3 increase. Separate physiologic effects were observed for summer ambient concentrations of two different pollutants (PEF decrements related to PM2.5 in morning and O3 in evening) at concentrations below the new U.S. EPA 24-h ambient air quality standard for PM2.5 and 8-h standard for O3.
Victims of domestic violence on the trauma service: unrecognized and underreported.

BACKGROUND Domestic violence (DV) has received increased recognition as a significant mechanism of injury. To improve awareness about DV at our institution, an educational program was presented to the departments of surgery and emergency medicine. Pre and posttests were given and improvement in knowledge was demonstrated. In addition, a screening question for DV was added to the trauma history and physical (H & P) form. This study was done to determine the long-term efficacy of these efforts in increasing recognition of DV and referral to social services in patients admitted to the trauma service. Recognition of DV and appropriate referral should be increased after education and change in H & P form. METHODS All patients admitted to the trauma service at a Level I trauma center over a 10 month period with the mechanism of injury "assault" were reviewed. DV was determined to be present, likely, unknown, or absent based on information from the prehospital report and medical records. The DV screen question was reviewed for use and accuracy. RESULTS During the study period, 1,550 patients were admitted to the trauma service, with assault listed as the mechanism of injury for 217 (14%). DV was confirmed or likely in 27 patients (12.4% of the assaults). Of patients with confirmed or likely DV, only 7 received appropriate referrals, with 2 generated by the nursing staff. Of the confirmed and likely DV patients, 17 (63%) were sent home without investigation of safety and only 21% of all assault victims had any social services evaluation (usually to investigate funding or placement). The DV screen was used in only 12 patients. Reasons given for failure to complete the DV screen on the H & P included examiner discomfort in asking the question, and an environment judged to be inappropriate (resuscitation area in the emergency department). CONCLUSION DV is unrecognized and underreported. Efforts to improve recognition and reporting of DV events need to be ongoing. Screening for DV is not effectively done as part of the initial evaluation. Assessment for DV may be more appropriate as part of the tertiary survey.
Automating Commercial Video Game Development using Computational Intelligence

Problem statement: The retail sales of computer and video games have grown enormously during the last few years, not just in United States (US), but also all over the world. This is the reason a lot of game developers and academic researchers have focused on game related technologies, such as graphics, audio, physics and Artificial Intelligence (AI) with the goal of creating newer and more fun games. In recent years, there has been an increasing interest in game AI for producing intelligent game objects and characters that can carry out their tasks autonomously. Approach: The aim of this study is an attempt to create an autonomous intelligent controller to play the game with no human intervention. Our approach is to use a simple but powerful evolutionary algorithm called Evolution Strategies (ES) to evolve the connection weights and biases of feed-forward Artificial Neural Networks (ANN) and to examine its learning ability through computational experiments in a non-deterministic and dynamic environment, which is the well-known arcade game, called Ms. Pac-man. The resulting algorithm is referred to as an Evolution Strategies Neural Network or ESNet. Results: The comparison of ESNet with two random systems, Random Direction (RandDir) and Random Neural Network (RandNet) yields promising results. The contribution of this work also focused on the comparison between the ESNet with different mutation probabilities. The results show that ESNet with a high probability with high mean scores recorded compared to the mean scores of RandDir, RandNet and ESNet with a low probability. Conclusion: Overall, the proposed algorithm has a very good performance with a high probability of automatically generating successful game AI controllers for the video game.
Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part II. Kinase Regulators and Substrates

Filamentous actin or F-actin is a major component of stress fibers and involved in cellular architecture. Its dynamic rearrangement supports not only cellular morphology but also intracellular signal transduction that regulate cell-cell or cell-extracellular matrix interactions, cell motility, and proliferation. Several lines of evidence demonstrate that, in several organisms, oocyte cortical cytoskeleton involving F-actin network undergoes a dynamic rearrangement during meiosis/oocyte maturation and that this is often involving phosphorylation of actin and/or actin-interacting proteins (e.g. ADF/coffilin, see below) catalyzed by PKC (in Tubifex, Xenopus) (Capco et al. 1992; Shimizu 1997). In Drosophila, PKC phosphorylation of a tumor suppressor protein-homolog named Lgl (lethal (2) giant larvae) is responsible for actin-dependent oocyte polarity formation (Tian and Deng 2008). In mammalian oocytes (rat), F-actin has been implicated in tyrosine kinase-dependent
EVALUATION OF POLARIMETRIC CONFIGURATIONS FOR GLACIER CLASSIFICATION

We investigate the classification information contained in the different polarisation channels from a fully polarimetric scene of an arctic glacier. Specifically, we compare classifications from the full quadruple polarisation data; dual polarisation modes; and each single polarisation channel. The classifications are performed with both the standard Wishart classifier and a non-Gaussian based K-Wishart classifier. Post classification class histograms clearly show that the K-Wishart model is a better statistical fit to the glacier ice classes, and the classification images show noticeable differences. Furthermore, we demonstrate that the different polarisation channels hold differing class distinguishing information and use a (visual) goodness-of-fit to the class histograms as an indicator for an appropriate number of significant classes in each polarisation combination. As expected, the single polarisation channels hold the least information and the complete quadruple polarisation data holds the most.
Gonadal hormones modulate the potency of the disruptive effects of donepezil in male rats responding under a nonspatial operant learning and performance task

In contrast to estrogen in female rats, testosterone in male rats may decrease cholinergic activity in the brain, thereby attenuating behaviors mediated by the cholinergic system. To investigate this possibility, the interactive effects of the gonadal hormones and donepezil, an acetylcholinesterase (AChE) inhibitor, on the responding of male rats were examined under a multiple schedule of repeated acquisition and performance of response sequences and on AChE activity in specific brain regions. Donepezil dose-effect curves (0.56–10 mg/kg) were determined in males that were gonadally intact, gonadectomized (GX), GX with testosterone replacement (GX+T) or GX with estradiol replacement (GX+E). In all four groups, donepezil produced dose-dependent rate-decreasing and error-increasing effects in the acquisition and performance components. However, disruptions of response rate and accuracy in both components occurred at lower doses in GX and GX+E males than in intact males. The GX+E males also had the highest percentage of errors under control (saline) conditions in the acquisition components. In terms of AChE activity, GX males had higher levels in the prefrontal cortex, striatum and hippocampus, but lower levels in the midbrain, compared with intact males; hypothalamic and cortical levels were comparable for the GX and intact groups. Together, these results in male rats indicate that the potency of donepezil's disruptive effects on the responding under a complex operant procedure requiring learning and performance of response sequences depends upon the gonadal hormone status, and that the effects of testosterone on cholinergic activity vary among brain regions.
Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye

Eyes often take a central role in discussions of evolution, with debate focused on how often such complex organs might have evolved. One such debate is whether arthropod compound eyes are the product of single or multiple origins. Here we use molecular phylogeny to address this long-standing debate and find results favoring the multiple-origins hypothesis. Our analyses of DNA sequences encoding rRNA unequivocally indicate that myodocopids—the only Ostracoda (Crustacea) with compound eyes—are nested phylogenetically within several groups that lack compound eyes. With our well-supported phylogeny, standard maximum likelihood (ML) character reconstruction methods significantly reconstruct ancestral ostracods as lacking compound eyes. We also introduce a likelihood sensitivity analysis, and show that the single-origin hypothesis is not significantly favored unless we assume a highly asymmetric model of evolution (one favoring eye loss more than 30:1 over gain). These results illustrate exactly why arthropod compound eye evolution has remained controversial, because one of two seemingly very unlikely evolutionary histories must be true. Either compound eyes with detailed similarities evolved multiple times in different arthropod groups or compound eyes have been lost in a seemingly inordinate number of arthropod lineages.
Genetic and Immunological Complexity of Major Histocompatibility Regions

There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.
A clinicopathological surprise: amelanotic malignant melanoma

A 58-year-old woman presented with a 20-year history of an asymptomatic, dry, scaly, erythematous, nonpigmented patch on the lateral aspect of her left upper arm. This had gradually increased in size, to its current dimensions of 26 · 32 mm (Fig. 1). The lesion was suggestive of Bowen s disease clinically, and an incisional skin biopsy was taken to confirm the diagnosis. Histologically, a lentiginous and junctional proliferation of moderately to severely atypical melanocytes with scattered pagetoid spread and a dense band-like infiltrate was observed, consistent with malignant melanoma in situ. Melan-A highlighted the melanoma in situ and absence of invasive disease. The lesion was therefore excised with 5 mm margins. Histological assessment of the excision specimen revealed a multifocal superficial spreading malignant melanoma, Breslow thickness 0.34 mm, Clark s level 2 (Fig. 2a) with a predominant in situ component, and with regression. Both the in situ and invasive components were confirmed with Melan-A (Fig. 2b). Re-excision with a further 5-mm margin was therefore performed and showed no evidence of residual melanoma. The term amelanotic melanoma is loosely used to describe both true amelanotic lesions which are devoid of pigment and melanomas with minimal residual pigmentation. The reported incidence of amelanotic melanoma varies from 1.8–8.1% of melanomas, but these figures include partially pigmented lesions. It is therefore difficult to ascertain the incidence of truly amelanotic melanoma. The majority of amelanotic melanomas reported are metastatic deposits, but of the primary lesions, in situ lentigo maligna, lentigo maligna melanoma and subungual lesions occur more commonly than other melanoma subtypes. Amelanotic superficial spreading melanoma is rare, with isolated case reports and one small series in the literature. Diagnosis of truly amelanotic lesions is difficult, especially if they present as scaly plaques resembling inflammatory dermatoses. Although dermoscopy may assist in the diagnosis of minimally pigmented lesions, it does not show proven efficacy with truly amelanotic lesions. Amelanotic lesions are frequently misdiagnosed, and in 63% of cases (44 ⁄ 70), mistreated before sampling for histological analysis. A review of our patient s lesion, even with the knowledge of the histological diagnosis, did not identify any clinical features suspicious of malignant melanoma. The gold-standard treatment for in situ melanoma is surgical excision using either Mohs micrographic surgery or taking 5-mm margins of clinically normal surrounding skin. In specific clinical scenarios, other PD
Investigation of optimal allocation of wind DG in distribution system

Optimum location of Wind based Distributed Generation unit is requisite as allocation at non-optimal places may effect system performance. The Wind DG unit supplies real power but consumes reactive power. In this paper analysis is being done for the possible improvement in system voltage profile and reduction of system losses by the addition of wind DG in a distribution system with the help of NR and Analytical expression. Results shows that Wind DG placed at proper place could be very effective for the system. For demonstrating the performance of approach IEEE 14 bus and IEEE 33 bus are taken as test systems and outcomes are discussed.
On Jet Opening Angle and Dynamical Evolution of Some Powerful Extragalactic Radio Sources

We used both analytical and statistical methods of analyses to find out if there is possible connection between jet opening solid angle and linear size evolution of some powerful extragalactic radio sources in our sample. Based on simple linear regression analyses of D-Ω data (where D is observed linear size and Ω is estimated jet opening solid angle), we found with a marginal correlation, that effects contributed by the opening angle may be overshadowed by other factors. A plausible interpretation of the result is that there is presence of appreciable ambient gases around these sources.
Comment on "The Role of Concentration Dependent Static Permittivity of Electrolyte Solutions in the Debye-Hückel Theory".

In their recent paper,1 Shilov and Lyashchenko (SL) extended the Debye–Hückel (DH) theory (denoted as EDH in this work) for the case when the dielectric constant of the electrolyte can vary with salt concentration, ε(c), which is a strong experimental evidence2–5 (an idea advocated by Hückel6 as early as 1925). They divide the thermodynamic functions into two parts representing interionic and ion–water (solvation) interactions denoted by numbers 1 and 2, respectively. These terms clearly correspond to the II (ion–ion) and IW (ion–water) terms in the excess chemical potential introduced in our II+IW model:7–10
Charged Amino Acid Frequencies of Proteins over Macroevolutionary Time Scale

Charged amino acids (AAs) are targets for selective forces in protein evolution. To fully explore the trend of charged AA frequencies evolution in macroevolutionary process from prokaryotes to eukaryotes, we extend the analysis of five charged AAs separately and total basic and acidic AAs in protein sequences of 158 prokaryotic and 63 eukaryotic predicted proteomes and 456 clusters of orthologous groups (COGs). Also, we eliminate the biases that may caused by extreme organisms in both predicted proteomes and COGs analyses. More basic AAs, His,Lysand Glu were found in eukaryotic proteins compared with prokaryotic proteins by predicted proteomes analysis. By COGs analysis, we found that basic AAs andLysfrequencies are higher in eukaryotic orthologous proteins than their prokaryotic companions, while the trend of Arg frequency is the opposite. We discussed the agreements and disagreements of two analyses and gained a more credible trend of charged AAs evolution in macroevolutionary time scale.
Transversal Game on Hypergraphs and the 3/4-Conjecture on the Total Domination Game

The $\frac{3}{4}$-Game Total Domination Conjecture posed by Henning, Klavžar, and Rall [Combinatorica, (2016)] states that if $G$ is a graph on $n$ vertices in which every component contains at least three vertices, then $\gamma_{tg}(G) \le \frac{3}{4}n$, where $\gamma_{tg}(G)$ denotes the game total domination number of $G$. Motivated by this conjecture, we raise the problem to a higher level by introducing a transversal game in hypergraphs. We define the game transversal number, $\tau_g(H)$, of a hypergraph $H$, and prove that if every edge of $H$ has size at least 2, and $H \ncong C_4$, then $\tau_g(H) \le \frac{4}{11}(n_{_H}+m_{_H})$, where $n_{_H}$ and $m_{_H}$ denote the number of vertices and edges, respectively, in $H$. Further, we characterize the hypergraphs achieving equality in this bound. As an application of this result, we prove that if $G$ is a graph on $n$ vertices with minimum degree at least 2, then $\gamma_{{tg}}(G) < \frac{8}{11} n$. As a consequence of this result, the $\frac{3}{4}$-.
A new medium for the enumeration and subculture of bacteria from potable water

Plate count agar is presently the recommended medium for the standard bacterial plate count (35 degrees C, 48-h incubation) of water and wastewater. However, plate count agar does not permit the growth of many bacteria that may be present in treated potable water supplies. A new medium was developed for use in heterotrophic plate count analyses and for subculture of bacteria isolated from potable water samples. The new medium, designated R2A, contains 0.5 g of yeast extract, 0.5 g of Difco Proteose Peptone no. 3 (Difco Laboratories), 0.5 g of Casamino Acids (Difco), 0.5 g of glucose, 0.5 g of soluble starch, 0.3 g of K2HPO4, 0.05 g of MgSO4 X 7H2O, 0.3 g of sodium pyruvate, and 15 g of agar per liter of laboratory quality water. Adjust the pH to 7.2 with crystalline K2HPO4 or KH2PO4 and sterilize at 121 degrees C for 15 min. Results from parallel studies with spread, membrane filter, and pour plate procedures showed that R2A medium yielded significantly higher bacterial counts than did plate count agar. Studies of the effect of incubation temperature showed that the magnitude of the count was inversely proportional to the incubation temperature. Longer incubation time, up to 14 days, yielded higher counts and increased detection of pigmented bacteria. Maximal bacterial counts were obtained after incubation at 20 degrees C for 14 days. As a tool to monitor heterotrophic bacterial populations in water treatment processes and in treated distribution water, R2A spread or membrane filter plates incubated at 28 degrees C for 5 to 7 days is recommended. (ABSTRACT TRUNCATED AT 250 WORDS)