Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical and psychosocial risk factors for musculoskeletal disorders in New Zealand nurses, postal workers and office workers

Objective To investigate the association of physical and psychosocial risk factors with musculoskeletal disorders (MSDs) in New Zealand nurses, postal workers and office workers. Design A cross-sectional postal survey asking about demographic, physical and psychosocial factors and MSDs. Participants A total of 911 participants was randomly selected; nurses from the Nursing Council of New Zealand database (n=280), postal workers from their employer's database (n=280) and office workers from the 2005 electoral roll (n=351). Outcome Measures Self-reported pain in the low back, neck, shoulder, elbow, wrist/hand or knee lasting more than 1 day in the month before the survey. Results The response rate was 58%, 443 from 770 potential participants. 70% (n=310) reported at least one MSDs. Physical work tasks were associated with low back (odds ratio (OR) 1.35, 95% CI 1.14 to 1.6), shoulder (OR 1.41, 95% CI 1.17 to 1.69), elbow (OR 1.14, 95% CI 1.13 to 1.83) and wrist/hand pain (OR 1.39, 95% CI 1.15 to 1.69). Job strain had the strongest association with neck pain (OR 3.46, 95% CI 1.30 to 9.21) and wrist/hand pain. Somatisation was weakly associated with MSDs at most sites. Better general and mental health status were weakly associated with lower odds of MSDs. Conclusions In injury prevention and rehabilitation the physical nature of the work needs to be addressed for most MSDs, with modest decreases in risk seemingly possible. Addressing job strain could provide significant benefit for those with neck and wrist/hand pain, while the effects of somatisation and the promotion of good mental health may provide smaller but global benefits.
Porokeratotic adnexal ostial naevus: review on the entity and therapeutic approach

Porokeratotic adnexal ostial nevus (PAON) is a term that encompass porokeratotic eccrine ostial and dermal duct naevus and porokeratotic eccrine and hair follicle naevus. PAON is a rare adnexal hamartoma characterized by the presence of a cornoid lamella exclusively overlying eccrine acrosyringia or over both, eccrine acrosyringia and hair follicles.
Running head: SIMILARITIES BETWEEN ADLERIAN AND BIBLICAL PRINCIPLES 1 The Similarities between Adlerian Principles and Biblical Principles

The main discussion of this paper is on the similarities between Adlerian principles and biblical principles. Prior to this discussion, a preliminary foundation discussing Alfred Adler and other prominent contributors to Adlerian theory will be included. In addition, a background about the Bible and a general overview of Christianity is discussed. Because of the similarities between Adlerian principles and biblical principles, the benefits of this compatibility for Christian clients are noted. The continued discussion of the paper focuses on Adlerian principles and biblical principles that share similar concepts. SIMILARITES BETWEEN ADLERIAN AND BIBLICAL PRINCIPLES 3
Strategies for Reducing Decoding Cycles in Stochastic LDPC Decoders

This brief presents three strategies, including initialization based on Look Up Table (LUT), postprocessing based on bit flipping and hard decision based on the posterior information, to reduce the number of decoding cycles (DCs) for stochastic low-density parity-check decoding. For the standard IEEE 802.3an code, simulation indicates a 73.6% reduction in the average number of DCs with a satisfactory bit error rate. Moreover, hardware implementation shows that the area required for the proposed decoder is significantly reduced.
Modified space-time adaptive processing for dismount detection using synthetic aperture radar

This paper presents a new adaptive radar signal processing technique for dismount detection using Synthetic Aperture Radar (SAR). The new approach uses the complex nature of the Doppler response scattering from the dismounts rotary motion to modify the conventional Space-Time Adaptive Processing (STAP). This is used for dismount detection wherein resolution is dictated by the sensor system platform. The feasibility of the modified STAP (M-STAP) is demonstrated by simulations and by applying it to the Gotcha data set for dismount detection.
Prediction of breast tumor progression by integrity of free circulating DNA in serum.

PURPOSE Cell-free DNA circulating in serum is a candidate molecular biomarker for malignant tumors. Unlike uniformly truncated DNA released from apoptotic cells, DNA released from dead cancer cells varies in size. Serum DNA integrity, the ratio of longer fragments to total DNA, may be clinically useful for detecting breast cancer progression. PATIENTS AND METHODS Serum samples from 51 healthy females and 83 females with primary breast cancers (eight American Joint Committee on Cancer stage 0, 24 stage I, 27 stage II, 21 stage III, and three stage IV) were assessed preoperatively. Serum DNA integrity was assessed by fragment length-dependent quantitative real-time polymerase chain reaction of ALU DNA repeats. RESULTS Mean serum DNA integrity was significantly higher in patients with stage II, III, and IV breast cancers than in healthy females (P = .005, P < .0001, and P = .002, respectively). The receiver operating characteristic (ROC) curve for discriminating patients with stage II or more advanced breast cancers from healthy females had an area under the curve (AUC) of 0.79 (95% CI, 0.70 to 0.86). Mean serum DNA integrity was positively correlated to size of invasive cancers (r = 0.48; P < .0001) and significantly higher in the presence of lymphovascular invasion (LVI; 0.25 +/- 0.02 v 0.17 +/- 0.02; P < .0001) or lymph node (LN) metastasis (0.27 +/- 0.02 v 0.14 +/- 0.02; P < .0001). The ROC curve for discriminating LN metastasis had an AUC of 0.81 (95% CI, 0.72 to 0.89). Serum DNA integrity and LVI were significant for predicting LN metastasis in a multivariate analysis (P = .0002 and P < .0001, respectively). CONCLUSION Integrity of serum circulating DNA is a promising molecular biomarker for detecting breast cancer tumor progression and regional LN metastases.
Manifold Learning with Variational Auto-encoder for Medical Image Analysis

Manifold learning of medical images has been successfully used for many applications, such as segmentation, registration, and classification of clinical parameters by modeling anatomical variability. In many applications, two aspects, generative property and capturing shape variability have been considered very important[4]. In this project, we analyze brain MRI images by applying variational auto-encoder(VAE)[7, 8], which was introduced very recently and has received much attention in machine learning and computer vision community due to its promising generative results and manifold learning perspective. We evaluate the VAE on the OASIS dataset and experimental results show that it can learn low dimensional manifold that can be used for generation and classification of many clinical parameters. such as age, MMSE, and CDR.
Characterization of the plasticity‐related gene, Arc, in the frog brain

In mammals, expression of the immediate early gene Arc/Arg3.1 in the brain is induced by exposure to novel environments, reception of sensory stimuli, and production of learned behaviors, suggesting a potentially important role in neural and behavioral plasticity. To date, Arc has only been characterized in a few species of mammals and birds, which limits our ability to understand its role in modifying behavior. To begin to address this gap, we identified Arc in two frog species, Xenopus tropicalis and Physalaemus pustulosus, and characterized its expression in the brain of P. pustulosus. We found that the predicted protein for frog Arc shared 60% sequence similarity with Arc in other vertebrates, and we observed high Arc expression in the forebrain, but not the midbrain or hindbrain, of female túngara frogs sacrificed at breeding ponds. We also examined the time‐course of Arc induction in the medial pallium, the homologue of the mammalian hippocampus, in response to a recording of a P. pustulosus mating chorus and found that accumulation of Arc mRNA peaked 0.75 h following stimulus onset. We found that the mating chorus also induced Arc expression in the lateral and ventral pallia and the medial septum, but not in the striatum, hypothalamus, or auditory midbrain. Finally, we examined acoustically induced Arc expression in response to different types of mating calls and found that Arc expression levels in the pallium and septum did not vary with the biological relevance or acoustic complexity of the signal. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 813–825, 2010
Histochemical observations on the mouse uterus during the oestrous cycle.

Changes in the uterus of the mouse during the oestrous cycle have been examined histochemically to demonstrate any variation in the occurrence of acid phosphatase, lipids and polysaccharide com¬ plexes (PAS-positive material) mainly with reference to the epithelium. Acid phosphatase was shown to have a distinct pattern of activity at each stage of the oestrous cycle. There was no evidence for acid phos¬ phatase release, but a considerable build-up in large and small lysosomes was observed in the epithelium at metoestrus and di-oestrus. A different pattern was observed in the case of lipids and PAS-positive material. Lipids were found in considerable amounts at di-oestrus, pro-oestrus and metoestrus, whereas a strong PAS-positive reaction was observed at pro-oestrus and oestrus.
The complete mitochondrial genome of Octopus conispadiceus (Sasaki, 1917) (Cephalopoda: Octopodidae)

Abstract In this paper, we determined the complete mitochondrial genome of Octopus conispadiceus (Cephalopoda: Octopodidae). The whole mitogenome of O. conispadiceus is 16,027 basepairs (bp) in length with a base composition of 41.4% A, 34.8% T, 16.1% C, 7.7% G and contains 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a major non-coding region (MNR). The gene arrangements of O. conispadiceus showed remarkable similarity to that of O. vulgaris, Amphioctopus fangsiao, Cistopus chinensis and C. taiwanicus.
A High Molecular Weight Intermediate Filament-associated Protein in BHK-21 Cells Is Nestin, a Type VI Intermediate Filament Protein

BHK-21 fibroblasts contain type III vimentin/desmin intermediate filament (IF) proteins that typically co-isolate and co-cycle in in vitro experiments with certain high molecular weight proteins. Here, we report purification of one of these and demonstrate that it is in fact the type VI IF protein nestin. Nestin is expressed in several fibroblastic but not epithelioid cell lines. We show that nestin forms homodimers and homotetramers but does not form IF by itself in vitro. In mixtures, nestin preferentially co-assembles with purified vimentin or the type IV IF protein α-internexin to form heterodimer coiled-coil molecules. These molecules may co-assemble into 10 nm IF provided that the total amount of nestin does not exceed about 25%. However, nestin does not dimerize with types I/II keratin IF chains. The bulk of the nestin protein consists of a long carboxyl-terminal tail composed of various highly charged peptide repeats. By analogy with the larger neurofilament chains, we postulate that these sequences serve as cross-bridgers or spacers between IF and/or other cytoskeletal constituents. In this way, we propose that direct incorporation of modest amounts of nestin into the backbone of cytoplasmic types III and IV IFs affords a simple yet flexible method for the regulation of their dynamic supramolecular organization and function in cells.
Interruption in the medical interaction.

OBJECTIVES To describe patterns of interruption in the physician-patient interaction; specifically, to determine who interrupts, to determine if a shift in control occurs as a result of interruption, and to characterize the information gained when patients interrupt physicians. DESIGN Observational. SETTING Community-based primary care practices in North Carolina. SUBJECTS Internists and family physicians in private practice in North Carolina (six men and two women) and their patients (13 men and 27 women). INTERVENTIONS None. MAIN OUTCOME MEASURE The obtainment of control of the interaction, at least momentarily, as a result of interruption. RESULTS Analysis of 40 audiotaped interactions revealed 833 interruptions (mean +/- SD, 20.8 +/- 12.2 per interaction): Patients initiated 55% of all interruptions. Physicians and patients each gained control of the conversation after 50% of interruptions. Patients gained control after 74% of patient-initiated interruptions, and physicians gained control after 79% of physician-initiated interruptions. Patients were more likely to gain control by interrupting late in the interaction, and 75% of patient-initiated interruptions resulted in new information (solicited and unsolicited) being contributed to the interaction. CONCLUSION Interruption by patients can be an informative event.
Mesomechanical Homogenization of Inelastic Periodic Heterogeneous Media

The manuscript presents a novel model reduction approach for periodic heterogeneous media, which combines the multiple scale asymptotic (MSA) expansion method with the transformation field analysis (TFA) to reduce the computational cost of a direct homogenization approach without significantly compromising on solution accuracy. The evolution of failure in micro-phases and interfaces is modeled using eigendeformation. Adaptive model improvement strategy incorporating a hierarchical sequence of computational homogenization models is employed to control the accuracy of the model. We present the model formulation and computational details along with the verification (with respect to direct homogenization) and validation (with respect to physical experiments) studies.
Comments on “Two- and Four-Pole Tunable 0.7–1.1-GHz Bandpass-to-Bandstop Filters With Bandwidth Control”

In the above paper, the author presents theoretical analysis of coupling coefficient of coupled-line using the asymmetrically loaded resonator. The coupling coefficient is critical to control the bandpass-to-bandstop transformation and bandwidth. However, some errors have been found, which may affect the readers’ understanding and they will be indicated in this letter.
Parametrical and Textural Analysis of Sidescan Sonar Images of the Seafloor

This paper presents a comparative analysis of a new method of sidescan sonar imagery segmentation helpful in the estimation and spatial distribution of macrophytobentos in Arctic conditions. In our research, we designed three methods, two based on a parametric analysis of sidescan sonar echo signals and the third on a textural analysis relying on mathematical morphology. Acoustic observations were verified by video recordings and biological samplings. A single beam echosounder was also used. The Spitsbergen fjords represent a periglacial environment with great diversity of morphodynamic processes and sensitivity for global warming changes, so it is one of the most promising areas to study the influence of climate change on an ecosystem. Sidescan sonar is a very effective and economic tool for mapping marine vegetation on the seafloor, but interpretation of data still causes many problems especially in the specific conditions of the Arctic fjords (underwater rocks, postglacial sediments, steep slopes). Proposed segmentation and classification algorithms enable estimation of the bottom area covered by algae and, together with results of biological sampling and single beam echosounder measurements, estimation of algae biovolume and biomass.
Linked Lives: Dyadic Associations of Mastery Beliefs With Health (Behavior) and Health (Behavior) Change Among Older Partners

Objectives Mastery beliefs are known to contribute to healthy aging. However, it is an open question whether individual mastery-health associations impact the health of close long-term partners. Method We applied actor-partner interdependence models to 4-wave, 6-year longitudinal dyadic data from married and cohabitating partners in the Health and Retirement Study (N = 1,981 partners; age at baseline: M = 67 years, SD = 8.93, range 50-94 years). Results Higher individual mastery beliefs were associated with better individual physical health and health behaviors. Higher mastery beliefs were associated with subsequent increases in light physical activity. Having a partner with higher levels of mastery was uniquely associated with fewer functional limitations, better self-rated health, and more physical activity. Actor × Partner interaction effects for functional limitations indicated multiplicative associations of actor and partner mastery with health. Of note, mastery-health associations for individuals and their partners were invariant across age, gender, education, employment status, perceived stress over one's own and partner's health, and cognition. Discussion Findings suggest that partner mastery beliefs matter for the health (behaviors) of older adults. We discuss possible mechanisms underlying partner interrelations in mastery and health, their age invariance, and consider implications arising from our results.
Wafer ultra-thinning process for 3D stacked devices and the influences on the device characteristics

In the semiconductor industry, 3D integration using through-silicon via (TSV) has been considered to be a promising way for improving performance and density instead of conventional device scaling. Si wafer thinning is an important technology in 3D stacking. Since the ultra-thin device provides low aspect ratio TSV, several advantages can be expected, such as reduced parasitic RC delay, lower power consumption, and lower TSV residual stress. However, the effects of ultra-thinning on the device are still unclear. In this review, we report the results of the electrical characteristics before and after thinning down to 10 μm using FRAM (Ferroelectric Random Access Memory), HP (High performance) Logic, and DRAM (Dynamic Random Access Memory).
Improving prediction of protein secondary structure using physicochemical properties of amino acids

Protein Structure Prediction is important in the sense that it helps to extend knowledge about the understanding of protein structures and functions. The knowledge is essential for prediction of secondary structures of unknown proteins required for applications related to drug discovery. A novel technique for protein secondary structure prediction is presented here. In this work, two levels of multi-layer feed forward neural networks are used. In the first level network, sequence profiles from PSI-BLAST and physicochemical properties of amino acids are used for sequence to structure predictions. Confidence values of forming helix, sheet and coil, obtained from the first level network are then used with the second level network for structure to structure predictions. The overall prediction accuracy as obtained through experimentation is in the range of 75.58% to 77.48%. This method is trained and tested with nrDSSP datasets using four folds cross validation. It is also tested on target proteins of Critical Assessment of Protein Structure Prediction Experiment (CASP3) and achieves better results than PSIPRED over some target proteins.
MRI-guided focused ultrasound (MRgFUS) system for thermal ablation of prostate cancer: pre-clinical evaluation in canines

A transrectal MRgFUS system was tested in a canine prostate model. Focal volumes in each half of the prostate were targeted, with high energy in one half of the gland for ablation and in the other with lower-energy sonications to test our ability to localize the focal spot before causing thermal tissue damage. All sonications (n=155) were readily observed with proton resonance frequency (PRF) MR temperature imaging, contrast enhanced MRI and histology. The prostate gland moved during the experiments, demonstrating the need for motion tracking. The resultant focal temperature changes during the experiments were 24.2 ± 8.2°C.
Progress in the Diagnosis and Management of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is an idiopathic disease caused by chronic activation and inflammation within the gastrointestinal tract. Effectively induction and maintenance of disease remission and prevention of complications are the most important therapeutic goals in the IBD management. Recent advancement has provided new insights into the diagnosis and treatment option for patient with IBD. This review was aimed to present an overview of the current expanding knowledge about IBD diagnosis and management, including diagnostic and evaluation tools, such as genetic test, biochemical surrogate markers of activity, endoscopic techniques and radiological modalities, and therapeutic progress, which encompass medical, endoscopic and surgical interventions. With a better understanding of new information concerning IBD diagnosis and management will lead to the development of increasingly effective and individualized pharmacological treatment modality for IBD patients. Niu X1* 1Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, PR China *Corresponding author: Xiaoyin Niu, Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, 280 South Chongqing Road, Shanghai 200025, PR China, Email: niuxiaoyin@163.com Published Date: March 10, 2016 Gr up SM
Crystal structures of the ribonuclease MC1 mutants N71T and N71S in complex with 5'-GMP: structural basis for alterations in substrate specificity.

Ribonuclease MC1 (RNase MC1), isolated from bitter gourd seeds, is a uridine specific RNase belonging to the RNase T2 family. Mutations of Asn71 in RNase MC1 to the amino acids Thr (N71T) and Ser (N71S) in guanosine preferential RNases altered the substrate specificity from uridine specific to guanosine specific, as shown by the transphosphorylation of diribonucleoside monophosphates [Numata, T. , et al. (2001) Biochemistry 40, 524-530]. To elucidate the structural basis for the alteration of substrate specificity, crystal structures of the RNase MC1 mutants N71T and N71S, free or complexed with 5'-GMP, were determined at resolutions higher than 2 A. In the N71T-5'-GMP and N71S-5'-GMP complexes, the guanine moiety was, as in the case of the uracil moiety bound to wild-type RNase MC1, firmly stabilized in the B2 site by an extensive network of hydrogen bonds and hydrophobic interactions. Structure comparisons showed that mutations of Asn71 to Thr or Ser cause an enlargement of the B2 site, which then make it feasible to insert a guanine base into the B2 site of mutants N71T and N71S. This binding further allows for hydrogen bonding interaction of the side chain hydroxyl groups of Thr71 or Ser71 with the N7 atom of the guanine base. The mode of guanine binding of mutants N71T and N71S was found to be essentially identical to that of a guanosine preferential RNase NW from Nicotiana glutinosa. In particular, hydrogen bonds between the N7 atom of the guanine base and the hydroxyl groups of the amino acids at position 71 (RNase MC1 numbering) were completely conserved in three guanosine preferential enzymes, thereby indicating that the hydrogen bond may play an essential role in guanine binding in guanosine preferential RNases in the RNase T2 family. Consequently, it can be concluded that amino acids at position 71 (RNase MC1 numbering) serve as one of the determinants for substrate specificity (or preference) in the RNase T2 fimily by changing the size and shape of the B2 site.