Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of the atrial fibrillation better care pathway in the ENGAGE AF-TIMI 48 trial.

AIMS The Atrial fibrillation Better Care (ABC) pathway is endorsed by guidelines to improve care of patients with atrial fibrillation (AF). However, whether the benefit of ABC pathway-concordant care is consistent across anticoagulants remains unclear. We assessed the association between ABC-concordant care and outcomes in this post hoc analysis from the ENGAGE AF-TIMI 48 trial, which was reported prior to the initial description of the ABC pathway. METHODS AND RESULTS Patients were retrospectively classified as receiving ABC-concordant care based on optimal anticoagulation, adequate rate control, management of co-morbidities and lifestyle measures. Associations between ABC-concordance and outcomes were assessed with adjustment for components of the CHA2DS2-VASc and HAS-BLED scores. Of 20 926 patients, 7915 (37.8%) satisfied criteria of ABC-concordant care, which was associated with significantly lower incidence of stroke or systemic embolic event [stroke/SEE: hazard ratio (HRadj): 0.54; 95% confidence interval (CI): 0.47-0.63], major bleeding (HRadj 0.66; 95% CI: 0.58-0.75), major adverse cardiac events (HRadj 0.53; 95% CI: 0.48-0.58), primary net clinical outcome (composite of stroke/SEE, major bleeding or death; HRadj 0.61; 95% CI: 0.56-0.65), cardiovascular (CV) hospitalization (HRadj 0.78; 95% CI: 0.74-0.83), CV death (HRadj 0.52; 95% CI: 0.46-0.58), and all-cause mortality (HRadj 0.56; 95% CI: 0.51-0.62), P < 0.001 for each. These associations were qualitatively consistent for both edoxaban and warfarin and across patient subgroups. CONCLUSION Atrial fibrillation Better Care pathway-concordant care is associated with reductions across multiple CV endpoints and all-cause mortality, with benefit in edoxaban- and warfarin-treated patients and across patient subgroups. Increasing implementation of ABC-concordant care may improve clinical outcomes of patients with AF irrespective of anticoagulant.
SignalingEncephalomyelitis Is Regulated by AKT3 Induced Experimental Autoimmune during Myelin Oligodendrocyte Glycoprotein Suppression of Inflammatory Responses

AKT3, member of the serine/threonine kinase AKT family, is involved in a variety of biologic processes. AKT3 is expressed in immune cells and is the major AKT isoform in the CNS representing 30% of the total AKTexpressed in spinal cord, and 50% in the brain. Myelin-oligodendrocyte glycoprotein–induced experimental autoimmune encephalomyelitis (EAE) is a mouse model in which lymphocytes and monocytes enter the CNS, resulting in inﬂammation, demyelination, and axonal injury. We hypothesized that during EAE, deletion of AKT3 would negatively affect the CNS of AKT3 2 / 2 mice, making them more susceptible to CNS damage. During acute EAE, AKT3 2 / 2 mice were more severely affected than wild type (WT) mice. Evaluation of spinal cords showed that during acute and chronic disease, AKT3 2 / 2 spinal cords had more demyelination compared with WT spinal cords. Quantitative RT-PCR determined higher levels of IL-2, IL-17, and IFN- g mRNA in spinal cords from AKT3 2 / 2 mice than WT. Experiments using bone marrow chimeras demonstrated that AKT3 2 / 2 mice receiving AKT3-deﬁcient bone marrow cells had elevated clinical scores relative to control WT mice reconstituted with WT cells, indicating that altered function of both CNS cells and bone marrow–derived immune cells contributed to the phenotype. Immunohistochemical analysis revealed decreased numbers of Foxp3 + regulatory T cells in the spinal cord of AKT3 2 / 2 mice compared with WT mice, whereas in vitro suppression assays showed that were less susceptible to regulatory T cell–mediated suppression than counterparts. These results indicate that contributes to the protection of mice against EAE. The Journal of Immunology , 2013, 190: 000–000.
Burnout, Depression, Anxiety, and Stress Among Family Physicians in Kansas: 18 Months into the COVID-19 Pandemic

Introduction: Given the significant turmoil during the COVID-19 pandemic, the authors evaluated burnout and other types of emotional distress experienced by family physicians in Kansas during the second year of the pandemic. The authors compared findings of this study to a similar study conducted 3 months into the pandemic. Methods: A cross-sectional online survey of 272 actively practicing family physicians in Kansas was conducted from September 15 to October 18, 2021. A 34-item questionnaire was used to measure the physicians’ levels of burnout, personal depression, anxiety, and stress. A mixed method approach was used to collect, analyze, and interpret the data. Descriptive statistics, Mann-Whitney U test/independent samples t-test, χ2, adjusted odds ratio, and immersion-crystallization methods were used to analyze the data. Results: The response rate was 48.9% (n = 133). In aggregate, 69.2% of respondents reported at least 1 manifestation of professional burnout in 2021 compared with 50.4% in 2020; P ≤ . 01). The 2021 respondents were at higher odds of experiencing burnout compared with 2020 respondents (aOR = 1.86; 95% CI, 1.00 to 3.57; P = .046). The respondents who reported at least 1 manifestation of professional burnout were more likely to screen positive for depression (aOR = 1.87; 95% CI, 1.31-2.66; P ≤ .01), report higher levels of anxiety (aOR = 1.53; 95% CI, 1.04-2.24; P = .013), and higher levels of stress (aOR = 1.39; 95% CI, 1.17-1.66; P ≤ .001). Conclusion: As the COVID-19 pandemic continued, there are significant and worsening rates of professional burnout and other forms of emotional distress among family physicians. These findings suggest timely need for appropriate psychological supports.
Psychological predictors of health anxiety and pain in ambulatory presentations in a hospital emergency department

Abstract Background: Health anxiety in attendees of out-patient medical clinics is well established; however, there has been a lack of research into health anxiety within emergency settings. Aims: This study explored the prevalence of health anxiety in ambulatory presentations in a tertiary emergency department (ED) as well as the factors associated with pain and health anxiety in this setting. Method: A cross-sectional questionnaire design was used to gather data from adult ED ambulatory attendees across a 4-day sampling period to assess psychological and physical health variables. Number of attendances to ED over the previous 12 months was accessed through healthcare records. Results: Of the final sample (n = 106), 77% were white British, 54% were male, and 14% presented with severe health anxiety as measured by the Short Health Anxiety Inventory (≥18). Participants with pre-existing health conditions had significantly higher levels of health anxiety (M = 12.36, SE = 1.59) compared with those without (M = 7.79, SE = 0.66). Stepwise multiple regression analyses identified anxiety sensitivity and pain catastrophizing as significant independent predictors of health anxiety, explaining 51% of the variance in health anxiety. Pain catastrophizing was also a significant independent predictor of pain level, accounting for 20% of the variance. Conclusion: This study provides insight into the prevalence of health anxiety in ED ambulatory presentations and key psychological predictors of health anxiety and pain. This has implications for treatment in an ED setting whereby patients may benefit from referral to medical psychology or mental health services.
Prevalence of root canal treatment worldwide: A systematic review and meta‐analysis

Abstract Background The prevalence of root filled teeth (RFT) worldwide will inform about the amount of clinical activity of dentists dedicated to treat endodontic disease. Objectives To carry out a systematic review with meta‐analysis answering the following question: What is the prevalence of RFT around the world? The percentage of people with at least one RFT was also investigated. Methods A systematic review including population‐based studies using the following databases: PubMed, EMBASE and Scielo. Studies related to prevalence of RFT were included. The outcome of interest of the study was the prevalence of RFT. The meta‐analyses were calculated with the Open Meta Analyst software to determine the global prevalence of RFT. Subgroups analyses were performed comparing geographical distribution, radiographic method and year of the study (classified in 20th or 21th century). The prevalence of people with at least one RFT was also analysed. Results Seventy‐four population‐based studies fulfilled the inclusion criteria. Twenty‐eight, forty‐four and two studies reported high, moderate and low risk of bias, respectively. No obvious publication bias was observed. Prevalence of RFT was estimated with 1 201 255 teeth and 32 162 patients. The calculated worldwide prevalence of RFT was 8.2% (95% CI = 7.3%–9.1%; p < .001). The global prevalence of people with at least one RFT was 55.7% (95% CI = 49.6%–61.8%; p < .001). In 20th century, the prevalence of RFT was 10.2% (95% CI = 7.9%–12.5%; p < .001), whereas in the 21st century the overall calculated prevalence of RFT was 7.5% (95% CI = 6.5%–8.6%; p < .001). Brazilian people (12%) and the European population (9.3%) showed the highest prevalence of RFT. In Europe, 59.6% (95% CI = 52.4%–66.8%) of people has at least one RFT. Conclusions This review showed that root canal treatment is a very common therapy throughout the world. More than half of the studied population have at least one RFT. A limitation of the present study is that most of the studies did not consider random sampling for population selection. Registration PROSPERO Systematic review registration number: (CRD42022329053).
Specific cognitive domains and frailty trajectories among older Taiwanese adults

Abstract Objective: To investigate the associations of specific cognitive functions and with the frailty trajectory among older Taiwanese adults. Methods: At baseline, 730 community-dwelling older adults were recruited from outpatient clinics of a general hospital. Frailty status was defined using phenotype criteria. Global cognition was assessed using the modified Telephone Interview of Cognitive Status and Mini-Mental State Examination (MMSE). The Mattis Dementia Rating Scale (MDRS) and Digit Symbol Substitution Test were used to evaluate 6 cognitive domains: attention, initiation/perseveration, construction, conceptualization, memory, and processing speed. The group-based trajectory model was used to identify latent frailty trajectory groups and the multinomial logistic regression was to examine the relationships of specific cognitive functions with frailty trajectory. Results: Among 485 participants (168 men, 317 women, and mean age: 71.1 ± 5.5 years) completed 2 annual follow-up assessments, three frailty trajectory groups of improvement, no-change, and progression were identified. After adjusting for baseline frailty status, age, sex, global cognition, regular exercise habit, and number of comorbidities, higher scores on MDRS’s initiation/perseveration (odds ratio [OR] = 0.85; 95% CI = 0.75-0.95) and attention (OR = 0.63; 95% CI = 0.38-1.00), respectively, were significantly associated with lower risk of frailty progression. Conversely, no significant association was detected between MMSE or TICSM scores and frailty improvement or progression. Conclusion: Specific cognitive functions of initiation/perseveration and attention, rather than global cognition, may be more useful to predict frailty progression, thus allowing the identification of at-risk older adults.
Transmission dynamics and control 1 of multidrug-resistant Klebsiella 2 pneumoniae in neonates in a 3 developing country 4

16 Multidrug-resistant Klebsiella pneumoniae is an increasing cause of infant mortality in developing 17 countries. We aimed to develop a quantitative understanding of the drivers of this epidemic by 18 estimating the e ects of antibiotics on nosocomial transmission risk, comparing competing 19 hypotheses about mechanisms of spread, and quantifying the impact of potential interventions. 20 Using a sequence of dynamic models, we analysed data from a one-year prospective carriage study 21 in a Cambodian neonatal intensive care unit with hyperendemic third-generation 22 cephalosporin-resistant K. pneumoniae. All widely-used antibiotics except imipenem were 23 associated with an increased daily acquisition risk, with an odds ratio for the most common 24 combination (ampicillin + gentamicin) of 1.96 (95% CrI 1.18, 3.36). Models incorporating genomic 25 data found that colonisation pressure was associated with a higher transmission risk, indicated 26 sequence type heterogeneity in transmissibility, and showed that within-ward transmission was 27 insu cient to maintain endemicity. Simulations indicated that increasing the nurse-patient ratio 28 could be an e ective intervention. 29
Radio Resource Unit Allocation and Rate Adaptation in Filter Banks Multicarrier System

— In this paper, the effect of the effective channel gain and the SNR using the improved joint resource unit (RU) allocation and Bit loading (JRAB) on a filter banks multicarrier (FBMC) system are analyzed. Computer simulations have been performed assuming a hypothetical WiMAX scenario in which an FBMC system substitutes OFDM by maintaining as much as possible the physical layer compatibility. From obtained simulation results it has been demonstrated that it is possible to upper-bound the maximum delay for delay-sensitive applications (rtPS and nrtPS) using the above mentioned effective metrics in a FBMC system.
University of Birmingham Enacting corporate governance of health care safety and quality

The governance of patient safety is a challenging concern for all health systems. Yet, while the role of executive boards receives increased scrutiny, the area remains theoretically and methodologically underdeveloped. Speci ﬁ cally, we lack a detailed understanding of the performative aspects at play: what board members say and do to discharge their accountabilities for patient safety. This article draws on qualitative data from overt non-participant observation of four NHS hospital Foundation Trust boards in England. Applying a dramaturgical framework to explore scripting, setting, staging and performance, we found important differences between case study sites in the performative dimensions of processing and interpretation of infection control data. We detail the practices associated with these differences - the legitimation of current performance, the querying of data classi ﬁ cation, and the naming and shaming of executives – to consider their implications.
The Murine DUB-1 Gene Is Speciﬁcally Induced by the (cid:98) c Subunit of the Interleukin-3 Receptor

Cytokines regulate cell growth and differentiation by inducing the expression of speciﬁc target genes. We have recently isolated a cytokine-inducible, immediate-early cDNA, DUB-1 , that encodes a deubiquitinating enzyme. The DUB-1 mRNA was speciﬁcally induced by the receptors for interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5, suggesting a role for the (cid:98) common ( (cid:98) c) subunit known to be shared by these receptors. In order to identify the mechanism of cytokine induction, we isolated a murine genomic clone for DUB-1 containing a functional promoter region. The DUB-1 gene contains two exons, and the nucleotide sequence of its coding region is identical to the sequence of DUB-1 cDNA. Various regions of the 5 (cid:42) ﬂanking region of the DUB-1 gene were assayed for cytokine-inducible activity. An enhancer region that retains the (cid:98) c-speciﬁc inducible activity of the DUB-1 gene was identiﬁed. Enhancer activity was localized to a 112-bp fragment located 1.4 kb upstream from the ATG start codon. Gel mobility shift assays revealed two speciﬁc protein complexes that bound to this minimal enhancer region. One complex was induced by (cid:98) c signaling,
Chracterization of West European field isolates and vaccine strains of avian infectious laryngotracheitis virus by restriction fragment length polymorphism and sequence analysis

Abbreviations: CEO = chicken embryo GaHV-1 = gallid herpesvirus 1, ILT = infectious laryngotracheitis, ILTV = infectious laryngotracheitis virus, ORF = open 40 frame, PCR = polymerase chain reaction, RE = restriction endonuclease, RFLP = restriction fragment length polymorphism, TCO = tissue culture TK = thymidine polymorphism (RFLP) analysis. 15 μ l of each amplification product was digested by 1 μ l of tetranucleotide-recognizing RE Hae III (Roche) using 10 μ l RE buffer M supplied by the 149 manufacturer in a final volume of 100 μ l at 37°C for one hour. The digested DNA was 150 precipitated, pelleted by centrifugation, rinsed, centrifuged again, and air dried, as described 151 above, resuspended in 10 μ l demineralized water and stored at 4°C for 40 min. DNA 152 fragments were separated by electrophoresis (70 V for 2 hours) in a 2% agarose gel (Agarose 153 Standard Eurobio) in 1x TAE buffer (Tris-acetate 40 mM, EDTA 2 mM, pH 8.0) containing 154 ethidium bromide (3 μ l/100 ml) to stain the DNA. The size of DNA RE fragments was 155 compared with a molecular weight marker (peqGOLD 100 bp DNA-Leiter Plus, PEQLAB, 156 Germany) ranging from 100 bp to 3000 bp bands. Bands were visualized using UV- 157 transillumination (Alpha Innotech, CA, USA) and photographed.
Looking for a Matrix model of ABJM

Encouraged by the recent construction of fuzzy sphere solutions in the ABJM theory, we re-analyze the latter from the perspective of a Matrix-like model. In particular, we argue that a vortex solution exhibits properties of a supergraviton, while a kink represents a 2-brane. Other solutions are also consistent with the Matrix-type interpretation. We study vortex scattering and compare with graviton scattering in the massive ABJM background, however our results are inconclusive. We speculate on how to extend our results to construct a Matrix theory of ABJM.
APPLICATION OF ROUGH SET THEORY FOR CHOOSING OPTIMAL LOCATION FOR FLOTATION TAILINGS DUMP

Flotation tailings dumps represent a potential threat to the environment. To corroborate this, numerous environmental disasters have occurred worldwide in the past. Pollution caused by breaking of tailings dump dams and overflowing of hazardous materials is still present, after several decades, and continue to threaten the environment. This paper presents a method for determining the most appropriate location for the flotation tailings dump using rough set theory. The review of the criteria that influence the choice of flotation tailings dump location is given. Based on these criteria, an analysis and evaluation of the proposed locations for the flotation tailings dump are done using rough set theory and the most suitable location that meets all the requirements is suggested.
ABCD2 Alters Peroxisome Proliferator-Activated Receptor a Signaling In Vitro, but Does Not Impair Responses to Fenofibrate Therapy in a Mouse Model of Diet-Induced Obesity s

Fenofibrate is a peroxisome proliferator-activated receptor (PPAR) a ligand that has been widely used as a lipid-lowering agent in the treatment of hypertriglyceridemia. ABCD2 (D2) is a peroxisomal long-chain acyl-CoA transporter that is highly induced by fenofibrate in the livers of mice. To determine whether D2 is a modifier of fibrate responses, wild-type and D2-deficient mice were treated with fenofibrate for 14 days. The absence of D2 altered expression of gene clusters associated with lipid metabolism, including PPAR a signaling. Using 3T3-L1 adipocytes, which express high levels of D2, we confirmed that knockdown of D2 modified genomic responses to fibrate treatment. We next evaluated the impact of D2 on effects of fibrates in a mouse model of diet-induced obesity. Fenofibrate treatment opposed the de-velopment of obesity, hypertriglyceridemia, and insulin resistance. However, these effects were unaffected by D2 genotype. We concluded that D2 can modulate genomic responses to fibrates, but that these effects are not sufficiently robust to alter the effects of fibrates on diet-induced obesity phenotypes. and pedigree as a random effect. Sensitivity analyses were conducted using the alternative phenotype definition of log-transformed plasma triglyceride concen- tration ratios comparing post- to prefenofibrate treatment levels. The study was adequately powered to detect the causal SNPs (power 5 99% for two loci at the significance level of 0.025). To address the multiple testing problem, we implemented a stringent Bonferroni correction, setting the a -level at 0.05/number of SNPs tested 5 0.05/2 5 0.025.
Communicating Efficiently on Cluster-Based Remote Direct Memory Access (RDMA) over InfiniBand Protocol

Distributed systems are commonly built under the assumption that the network is the primary bottleneck, however this assumption no longer holds by emerging high-performance RDMA enabled protocols in datacenters. Designing distributed applications over such protocols requires a fundamental rethinking in communication components in comparison with traditional protocols (i.e., TCP/IP). In this paper, communication paradigms in existing systems and new possible paradigms have been investigated. Advantages and drawbacks of each paradigm have been comprehensively analyzed and experimentally evaluated. The experimental results show that writing the requests to server and reading the response presents up to 10 times better performance comparing to other communication paradigms. To further expand the investigation, the proposed communication paradigm has been substituted in a real-world distributed application, and the performance has been enhanced up to seven times.
Demo: Accessible Deep Learning for the Scientiﬁc Community

—DeepForge is a gateway to deep learning for the sci-entiﬁc community. Utilizing a cloud-based infrastructure, Deep-Forge facilitates rapid development by promoting accessibility and reproducibility of experiments. In this demonstration, we present the core concepts of DeepForge and an image classiﬁcation example.
Portable Bio-signal Data Logger

Increased involvement of Data Acquisition in current world research has pushed the requirements of data acquisition systems. This is particularly true in Biomedical engineering, where portable, light and easily accessible DAQ systems are needed. These systems should be light so that they can be wore on the body and should have long battery life where it can be powered all day for comprehensive research data. Under my honor thesis, we designed a portable DAQ which can record the data on eight channel simultaneously for minimum of 6 hours. Comparing to the present market option for portable DAQ, this system is cost-effective, has multiple applications and great scope of customization. This system also features wireless accessibility on Windows, Mac, iOS, Android and Linux which make this system powerful and robust.
Two Higgs doublet models with local U(1)_H gauge symmetry and dark matter

We propose to implement the softly broken Z_2 symmetry in the usual two Higgs doublet model (2HDM) to spontaneously broken local U(1)_H gauge symmetry, and show that the resulting phenomenology can be very rich and is distinctly different from the usual 2HDMs. Likewise, the exact Z_2 symmetry in ordinary inert doublet model (IDM) could be a remnant of spontaneously broken local U(1)_H symmetry stabilizing dark matter (DM). In this case, new channels for DM pair annihilation into U(1)_H gauge boson(s) open up, allowing the DM mass below \lesssim 40 GeV, unlike the usual IDM.