Miracle-dz/UniFAR-FTUs huggingface dataset:
Dielectric response of Cr ̵ doped TiO_2 nanoparticles: Effect of doping concentration and annealing temperature

The combined effect of doping chromium (Cr) as well as annealing temperature on the dielectric spectroscopy performance of titanium (TiO2) was investigated. Accordingly, two series of chromium doped titania samples with the form (Ti1-xCrxO2) where X=0-25 mol% were fabricated utilizing the hydrolysis method. The first series was used as-synthesized while the second series was used after annealing at 500 °C for 1h. The microstructure of both synthesized series was characterized by X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET). The (XRD) result confirms the formation of the amorphous characteristics of such pure and r doped TiO2 (as-synthesized) and crystalline characteristics of such pure and Cr doped TiO2 (annealed at 500 °C for 1h). The average crystallite size in second series (annealed at 500 °C) as estimated by the Scherrer’s equation varies in the range of ~12–30 nm on doping of Cr ions in TiO2. The measured surface area of TiO2 is decreased by Cr doping in first series (as-synthesized) while it is increased by Cr doping in second series (annealed at 500 °C). The variation in both dielectric constant (ε'), and ac conductivity (σac) as a function of applied frequency at different doping concentration of Cr were investigated. The measurements confirms that both ε' and σac values of TiO2were decreased with Cr doping in first series and increased with Cr doping in second series.
The complete mitochondrial genome of the pink sea fan, Eunicella verrucosa (Pallas, 1766)

Abstract The pink sea fan, Eunicella verrucosa (Pallas, 1766), inhabits rocky substrates across the northeast Atlantic and the western Mediterranean. Across much of its range it has been detrimentally affected by fishing. DNA from 17 E. verrucosa specimens was amplified by phi29-induced rolling circle amplification. Following purification by sodium acetate-ethanol precipitation, the circular genomic DNA was sequenced on an Illumina MiSeq v2. Specimens originated from sites along the west coast of Ireland, southwest Wales, southwest/southern England, northwest France, southern Portugal, and the Mediterranean coast of northeast Spain. All samples had identical mitochondrial genome sequences of 19,267 bp and included 14 protein-coding genes (including the mutS gene), two ribosomal RNA subunits (12S and 16S) and one methionine tRNA gene. Two genes (nad2 and nad5) overlapped by 13 bp; all other genes were separated by non-coding intergenic regions. All protein-coding genes had the same start codon (ATG) and a TAA or TAG stop codon, except for cox1 that terminated with the incomplete stop codon T--. The mitochondrial genome of E. verrucosa (MW588805) showed 99.72% similarity with that of a related sea fan species, Eunicella cavolini, with six SNPs and a 49 bp deletion between nad5 and nad4 in E. verrucosa distinguishing the two.
Excessive Daytime Sleepiness among Chronic Kidney Disease Patients

Background:Excessive daytime sleepiness is defined as the incapacity to keep alert or awake during the major waking activities of the day, causing unintentional pauses of drowsiness or sleep. Chronic kidney diseasepatients commonly suffer from excessive daytime sleepiness which in turn affectstheir quality of life. Objectives: This prospective cross-sectional study was conductedto evaluate the prevalence of excessive daytime sleepiness among chronic kidney disease patients. Patients and methods: The study was carried out on one hundred patients with known chronic kidney disease who attended Aswan University hospital during the period between May 2017 and March 2020; 42.0% males and 58.0% females with a mean age of 53.9 ± 16.97 years. We evaluated day time sleepiness among those patients using Epworth Sleepiness Scale (ESS); the standardized score for the assessment of daytime sleepiness. Results: We found that 56% of the patients had excessive daytime sleepiness (ESS > 10) with themedian ESS of the participants was 10.0. There was no statistically significant correlation between the ESS and each of serum urea, serum creatinine, and eGFR. Conclusion:Excessive daytime sleepiness is common among CKD patients with a prevalence of 56% that may affect their quality of life.
Comparison of Hurst exponent estimation methods

Through recent years many researchers have developed methods to estimate the self-similarity and long memory parameter that is best known as the Hurst parameter. In this paper, we set a comparison between nine different methods. Most of them use the deviations slope to find an estimate for the Hurst parameter like Rescaled range (R/S), Aggregate Variance (AV), and Absolute moments (AM), and some depend on filtration technique like Discrete Variations (DV), Variance versus level using wavelets (VVL) and Second-order discrete derivative using wavelets (SODDW) were the comparison set by a simulation study to find the most efficient method through MASE. The results of simulation experiments were shown that the performance of the methods is relatively close, except for the SODDW method was the most efficient in MASE. Paper type Categorize your paper under one of these classifications: General review
Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics

Given the growing number of clinically integrated cancer single-cell transcriptomic studies, robust differential enrichment methods for gene signatures to dissect tumor cellular states for discovery and translation are critical. Current analysis strategies neither adequately represent the hierarchical structure of clinical single-cell transcriptomic datasets nor account for the variability in the number of recovered cells per sample, leading to results potentially confounded by sample-driven biology with high false positives instead of accurately representing true differential enrichment of group-level biology (e.g., treatment responders vs. non-responders). This problem is especially prominent for single-cell analyses of the tumor compartment, because high intra-patient similarity (as opposed to inter-patient similarity) results in stricter hierarchical structured data that confounds enrichment analysis. Furthermore, to identify signatures which are truly representative of the entire group, there is a need to quantify the robustness of otherwise statistically significant signatures to sample exclusion. Here, we present a new nonparametric statistical method, BEANIE, to account for these issues, and demonstrate its utility in two cancer cohorts stratified by clinical groups to reduce biological hypotheses and guide translational investigations. Using BEANIE, we show how the consideration of sample-specific versus group biology greatly decreases the false positive rate and guides identification of robust signatures that can also be corroborated across different cell type compartments.
A materials science approach towards bioinspired polymeric nanocomposites: a comprehensive review

Abstract Biological aspects of polymer nanocomposites (PNCs) depend on various factors like low toxicity, stimuli-responsive behavior, high compatibility, and large aspect ratio along with size-dependent properties of fillers. A range of parameters influencing the biological activities of PNCs is established in the present review. Biomedical applications of PNCs like drugs delivery, gene therapy, tissue engineering, cancer treatment, wound healing, dental curing, biosensing, and bioimaging are contained including antibacterial behaviors. Physical and biological characteristics are explained to enable the PNCs for various biomedical uses. For a better understanding of the subject, several schemes and comparative tables are established in different sections of the review. Graphical Abstract
PRMT1 Regulates EGFR and Wnt Signaling Pathways and Is a Promising Target for Combinatorial Treatment of Breast Cancer

Identifying new therapeutic strategies for triple-negative breast cancer (TNBC) patients is a priority as these patients are highly prone to relapse after chemotherapy. Here, we found that protein arginine methyltransferase 1 (PRMT1) is highly expressed in all breast cancer subtypes. Its depletion decreases cell survival by inducing DNA damage and apoptosis in various breast cancer cell lines. Transcriptomic analysis and chromatin immunoprecipitation revealed that PRMT1 regulates the epidermal growth factor receptor (EGFR) and the Wnt signaling pathways, reported to be activated in TNBC. The enzymatic activity of PRMT1 is also required to stimulate the canonical Wnt pathway. Recently developed type I PRMT inhibitors decrease breast cancer cell proliferation and show anti-tumor activity in a TNBC xenograft model. These inhibitors display synergistic interactions with some chemotherapies used to treat TNBC patients, as well as the EGFR inhibitor, erlotinib. Therefore, targeting PRMT1 in combination with drugs used in the clinic may improve current treatments for TNBC patients. Significance This study highlights the requirement of PRMT1 for breast cancer cell survival and demonstrates the potential of targeting type I PRMTs in combination with chemotherapies in triple-negative breast cancer.
Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma

Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Methods: Clinical data of these cases, submitted to São Paulo State University and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin and eosin and histologically evaluated. Survival analysis was carried out, and the prognostic value of the presence of lymphatic invasion and the treatment used was determined. Results: Dogs with neoplastic lymphatic vessel invasion had a lower overall survival compared to those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared to animals that received carboplatin in addition to surgery. Conclusion: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.
Atom Probe Tomography Analysis of Mica

Abstract Laser-assisted atom probe tomography (APT) is a relatively new, powerful technique for sub-nanometric mineral and biomineral analysis. However, the laser-assisted APT analysis of highly anisotropic and chemically diverse minerals, such as phyllosilicates, may prove especially challenging due to the complex interaction between the crystal structure and the laser pulse upon applying a high electric field. Micas are a representative group of nonswelling clay minerals of relevance to a number of scientific and technological fields. In this study, a Mg-rich biotite was analyzed by APT to generate preliminary data on nonisotropic minerals and to investigate the effect of the crystallographic orientation on mica chemical composition and structure estimation. The difference in results obtained for specimens extracted from the (001) and (hk0) mica surfaces indicate the importance of both experimental parameters and the crystallography. Anisotropy of mica has a strong influence on the physicochemical properties of the mineral during field evaporation and the interpretation of APT data. The promising results obtained in the present study open the way to future innovative APT applications on mica and clay minerals and contribute to the general discussion on the challenges for the analysis of geomaterials by atom probe tomography.
Evaluation of aqueous Ozone as a method to combat multidrug-resistant Staphylococcus aureus tainting cattle meat sold in Wasit marketplaces

Corresponding author: Manal Hadi Iraq/manalhadi73@yahoo.com Objective: To evaluate the effectiveness of ozonation treatment (1/2 ppm for up to 30 min at 3-7 centigrade) on the persistence of multidrug-resistance Staphylococcus aureus (MDR S. aureus) tainting cattle meat. Design: Descriptive study Procedures: Nine testers of cattle's meat including imported (n = 3) and locally slaughtered (n = 6), which were stored at -18 centigrade and accepted positive for MDR S. aureus were subjected to aqueous ozone (O3) as 1/2 ppm for 15 and 30 min. Results: The results presented that after ozonation treatment (1/2 ppm at 3-7 centigrade), the whole testers which free from MDR S. aureus were 22.2% & 55.6% for 15 & 30 min, respectively. Additionally, the antimicrobial effectiveness of aqueous O3 as 1/2 ppm on the decline of MDR S. aureus level (log 10 CFU/ml) was
Signs and Symptoms of Vitamin D Deficiency in Children: A Cross-Sectional Study in a Tertiary Pediatric Hospital in the United Arab Emirates

Objective: This study was conducted to estimate the common signs and symptoms present in patients with vitamin D deficiency at a children’s specialty hospital in Dubai, United Arab Emirates (UAE). Methods: This descriptive cross-sectional study (n = 805) examined patients aged <18 years with a serum 25-hydroxy vitamin D concentration of <50 ng/mL and presenting to the hospital between 2017 and 2018. Variables (age, gender, nationality, vitamin D levels, signs and symptoms, and primary complaint) were described using frequencies and mean values (SD). Chi-square and Kruskal-Wallis tests were conducted. Results: Among the 805 patients, 315 (39.2%) had vitamin D deficiency (<20 ng/mL). Regarding the symptoms of these 315 patients, 26% (n = 82) of them were asymptomatic, 13.3% (n = 42) of them had endocrine symptoms and other/rare symptoms, and 11.7% (n = 37) of them had gastrointestinal symptoms. The least common symptoms were found in the mixed category (mixed symptoms of different body systems), consisting of 3.5% (n = 11) of patients. Vitamin D deficiency was more common among female patients (44.8%) and Emiratis (40.5%), and the average age for patients to have vitamin D deficiency was nine years. Conclusion: To our knowledge, this is one of the first studies in the United Arab Emirates to focus on and examine patients with low vitamin D levels in detail. Determining the most frequent symptoms is helpful for healthcare practitioners because our results showed that most patients with the deficiency were asymptomatic. Hence, we recommend performing regular checkups for healthy and asymptomatic children to detect vitamin D deficiency before they show any symptoms.
Microwave hyperthermia application with bioimplant single slot coaxial antennadesign for mouse breast cancer treatment

: In this study, a novel animal model for the breast cancer treatment which contains hyperthermia is proposed. For this main purpose a low cost, interstitial, bioimplant antenna by short ended single slot design is proposed to heat the cancerous tissues. Both the theoretical background of the proposed system and the simulation and measurement results of antenna design are presented. An artificial tissue phantom model has been created under laboratory conditions and then the utility of the proposed antenna has been tested on this model. Artificial tissues have been heated by 25W to (41-44 ◦ C) in a short time like 25 s. Temperature measurement is performed in real-time and wireless by a digital temperature sensor using an embedded system platform. In addition, the effectuality of the proposed hyperthermia system has been tested by the study on live mice. For this purpose, breast cancer tissues created under laboratory conditions have been transferred to experimental group Balb/c mice to induce breast cancer. According to the results of hyperthermia treatment, the breast cancer has been inhibited by the proposed hyperthermia system. All studies have been animal care with ethics committee approval. All experiments have been repeated three times by at least two observers independently. The results of this study give hope that the breast cancer treatment method using this new antenna could be used in humans in the future. For this, the number of such types of ablation studies using this type of antenna should increase.
Case Study: Challenges in building and maturing an internet connection in rural mineral mining companies in South Africa

Connecting any company’s Local Access Network (LAN) to a Wide Area Network (WAN) or the internet should be relatively easy because there are technologies available that enable companies to connect seamlessly. However, in the rural parts of South Africa are some geographical and economical challenges when companies in rural areas want to connect their LAN to a WAN or the internet with the biggest challenges being the availability of technology and the affordability of technology for these small rural companies. This paper discusses these challenges experienced and proposes a framework that can be followed by these rural companies when connecting a LAN to a WAN or the internet.
Is Oscillospora Spp in the Nasopharyngeal Mucosa Associated with Atopic Dermatitis in Children?

post-flare-up period following treatment [9]. One study even found that treatment with emollients can reduce the proportion of S. aureus and increase microbiota diversity [10]. This study aimed to describe the composition, abundance and dominance of species; bacterial communities; and the biodiversity of the nasopharyngeal microbiota in children with and without AD. Abstract The arise of next generation sequencing (NGS) has improved the knowledge about the cutaneous and nasal microbiota in the development of atopic dermatitis (AD). Recently, it has been demonstrated that the microbiota plays a key role in this pathology. For our study we compared the nasal microbiome in children with AD versus healthy controls. Many different bacteria were found in this ecosystem; Staphylococcus aureus would appear to play a lesser role than suggested in studies based on nasopharyngeal cultures. However, the genus Oscillospira was more common in the children with AD and was also associated with lower body mass index. Further research is needed to understand the clinical importance of these findings in improving disease management.
Application of the Guided Inquiry Model to Improve Student's Motivation and Creativity

The application of an attractive learning model is one of the things that affect students' motivation and creativity in learning. The review results so far show that learning activities are still using conventional learning models such as direct learning models. The purpose of this study was to determine the application of the guided inquiry learning model in increasing students' motivation and creativity on temperature and heat material at SMAN 4 Wira Bangsa Aceh Barat. The research method used was pre-experimental with one group pretest-posttest design. The instrument used in the study consisted of a questionnaire. The results showed that applying the guided inquiry learning model could increase students' motivation in the matter of temperature and heat. Increasing students' learning motivation can be seen from the average N-gain value of 0.6, including the medium category. The results of the average difference test obtained a significance value of 0.000 <0.05, meaning that there was a significant difference before and after applying the guided inquiry learning model. Then the results of the analysis of indicators on aspects of attention, relevance, confidence, and satisfaction obtained a score > 80 then included in excellent categories. The application of the guided inquiry learning model can increase students' creativity in the material of temperature and heat. Increasing students' creativity can be obtained an average N-gain value of 0.7, including the high category. The results of the average difference test got a significance value of 0.000 < 0.05, meaning that there was a significant difference before and after applying the guided inquiry learning model. The results of the analysis of indicators through the results of questionnaires and observations consisting of fluency, flexibility, and novelty obtained an average score of > 75, including the high category. The conclusion in this study proves that the guided inquiry model can increase students' motivation and creativity on temperature and temperature heat materials
The impacts on the mental health of residents of 16 favelas observed during the coronavirus pandemic in Brazil

The COVID-19 pandemic in Brazil has caused a scenario of extreme social vulnerability, with high unemployment rates and severe cuts to social benefits and policies. Aims: analyze the impacts of the pandemic on the mental health and quality of life on people living in contexts of high-levels of armed and lethal violence and social fragility. Methods: A longitudinal cohort study was undertaken with a convenient sample of fifty individuals who live in 16 favelas in Rio de Janeiro (Brazil) before and during the COVID-19 pandemic. The interviews included enquired about the respondent’s capacity to cope with the pandemic and their access to services as well as questions about mental health (Brief Symptoms Inventory), and Quality of Life (Manchester Short Assessment of Quality of Life). Results: The results revealed a decrease in the somatization dimension of the BSI scale and a worsening on the objective index (SIX) of quality of life. Mental health distress increased more in the male group when compared to the female group during the COVID-19 pandemic. It seems likely; therefore, the COVID-19 pandemic presents a major challenge for people living in a context of urban violence and social deprivation. Conclusions: The worsening of mental distress and quality of life during the pandemic impacts both genders and suggests the need for policies directed to health and employment protection.
Genetic and morphological data demonstrate hybridization and backcrossing in a pair of salamanders at the far end of the speciation continuum

Deeply diverged yet hybridizing species provide a system to investigate the final stages of the speciation process. We study a hybridizing pair of salamander species—the morphologically and genetically drastically different newts Triturus cristatus and T. marmoratus—with a panel of 32 nuclear and mitochondrial genetic markers. Morphologically identified hybrids are mostly of the F1 generation and mothered by T. cristatus. The sex ratio of the F1 hybrid class is reciprocally skewed, with a preponderance of females in T. cristatus‐mothered hybrids and males in T. marmoratus‐mothered hybrids. This amounts to the Haldane effect operating in one direction of the cross. Deeper generation hybrids are occasionally produced, possibly including F1 hybrid × backcross hybrid offspring. Interspecific gene flow is low, yet skewed toward T. cristatus. This asymmetry may be caused by hybrid zone movement, with the superseding species being predisposed to introgression. The persisting gene flow between deeply differentiated species supports the notion that full genetic isolation may be selected against. Conversely, published morphological data suggest that introgressive hybridization is detrimental, with digital malformations occurring more frequently in the area of sympatry. Finally, to assist field identification, both within the area of natural range overlap and concerning anthropogenic introductions elsewhere, we document the phenotypical variation of two generations of hybrids compared with both parental species. We suggest that fluctuating range boundaries, ecological segregation, cytonuclear incompatibilities and hybrid breakdown through Bateson–Dobzhansky–Muller incompatibilities all contribute to species integrity, despite incomplete isolation during secondary contact.