Miracle-dz/UniFAR-FTUs huggingface dataset:
in Nude Mice and in Vitro Down-Regulation and Apoptosis in MCF7ras Cells Sodium Phenylacetate Induces Growth Inhibition and Bcl-2

Using a highly tumorigenic human breast cancer model (Ha-ras-trans fected MCF7 cell line) we analyzed the efficacy of the differentiation inducing agent sodium phenylacetate (NaPA), both in vitroand in vivo. NaPA-treated MCF7ras cells showed dose-dependent growth inhibition from 2.5 to 15 mM without apparent tOXIcity.Western blot analysis showed a Bcl-2 down-regulation after 48 h treatment with 5 nmi NaPA, together with apparition of apoptotic nuclei by DAPI staining. Mice bearing MCF7ras xenografts (n = 40) were treated for 2 weeks through s.c. -delivering osmotic pumps, followed by 6 weeks of daily i.p. NaPA administration. After 3 weeks, the treated tumors showed growth arrest without regression for the whole observation time, e.g., 12 weeks. Immu nohistochemical analysis showed Bcl-2 down-regulation and differentia tion patterns:decreaseof Ki-67and increaseofsteroid receptors(estrogen and progesterone receptors) compared to controls. Cells cultured from treated tumors (ILb) displayed pseudotrabecular disposition as MCF7ras cells treated in vitro. They also showed a higher NaPA sensitivity, together with 70% Bcl-2 down-regulation as compared to the derived cells of untreated tumors (II.a). When reinjected into nude mice, H.b cells in duced only one poorly vascularized, noninvasive tumor (8%) with lower proliferation Index, 100% progesterone receptor positive cells, and 35% terminal deoxynucleotidyltransferase-mediated dUTP-X nick end labeling (+) nuclei, as compared to 100% induction of highly vascularized and invasive tumors with 3% terminal deoxynucleotidyltransferase-mediated dUTP-X nick end labeling (+) nuclei induced by H.a cells.
Hard X-Ray Nanoprobe based on Refractive X-Ray Lenses

At synchrotron radiation sources, parabolic refractive x‐ray lenses allow one to built both full field and scanning microscopes in the hard x‐ray range. The latter microscope can be operated in transmission, fluorescence, and diffraction mode, giving chemical, elemental, and structural contrast. For scanning microscopy, a small and intensive microbeam is required. Parabolic refractive x‐ray lenses with a focal distance in the centimeter range, so‐called nanofocusing lenses (NFLs), can generate hard x‐ray nanobeams in the range of 100 nm and below, even at short distances, i. e. , 40 to 70 m from the source. Recently, a 47 × 55 nm2 beam with 1.7 ⋅ 108 ph/s at 21 keV (monochromatic, Si 111) was generated using silicon NFLs in crossed geometry at a distance of 47m from the undulator source at beamline ID13 of ESRF. This beam is not diffraction limited, and smaller beams may become available in the future. Lenses made of more transparent materials, such as boron or diamond, could yield an increase in flux of o.
PII: S0304-3835(02)00343-9

The survival of patients affected by cutaneous melanoma has improved dramatically in the last 10 years, because of earlier diagnosis. Despite this, the therapeutic results obtained in metastatic melanoma (MM) are very disappointing due to its poor responsiveness to cytotoxic agents. In this type of solid tumor, tumor chemosensitivity assays have been suggested to be an important tool to predict clinical responsiveness to therapy. Metastatic melanoma cells (MMCs) were obtained from subcutaneous melanoma metastases of five patients and cultured for several consecutive passages. An immunofluorescence and an electron microscopic study were performed in order to establish the ultrastructural and physiopathological features of MMCs. A sulphorodamine-B test was used to measure in vitro sensitivity of MMCs to temozolomide, cisplatin, vindesine, taxol and interpheron alpha-2a. Following a 72 h exposure, maximum activity was obtained with vindesine (median inhibitory concentration, IC50, 0.23 nM) and taxol (median IC50 0.31 nM). Cisplatin median IC50 values were higher (4.6 mM) than taxol and vindesine, but still in the range of clinically achievable plasma concentrations. Temozolomide inhibited cell proliferation only at very high concentrations (median IC50 228 mM). No significant cell growth inhibitory effects (#25%) were observed with interferon alpha-2a concentrations up to 8000 IU/ml. MMCs expressed progression markers typical of cutaneous metastatic melanoma and showed poor sensitivity in vitro to most anticancer drugs tested, including temozolomide. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
Quantum Mechanics and Reality

We begin by discussing ``What exists? '', i.e. ontology, in Classical Physics which provided a description of physical phenomena at the macroscopic level. The microworld however necessitates a introduction of Quantum ideas for its understanding. It is almost certain that the world is quantum mechanical at both microscopic as well as at macroscopic level. The problem of ontology of a Quantum world is a difficult one. It also depends on which interpretation is used. We first discuss some interpretations in which Quantum Mechanics does not provide a complete framework but has to be supplemented by extra ingredients e.g. (i) Copenhagen group of interpretations associated with the names of Niels Bohr, Heisenberg, von-Neumann, and (ii) de-Broglie-Bohm interpretations. We then look at some interpretations in which Quantum mechanics is supposed to provide the entire framework such as (i) Everett-deWitt many world, (ii) quantum histories interpretations. We conclude with some remarks on the rigidity of the formalism of quantum mechanics, which is sharp contrast to it's ontological fluidity.
Crystal structures of covalent complexes of β -lactam antibiotics with E. coli penicillin-binding protein 5: toward an understanding of antibiotic specificity

Penicillin-binding proteins (PBPs) are the molecular target for the widely used β -lactam class of antibiotics, but how these compounds act at the molecular level is not fully understood. We have determined crystal structures of E. coli PBP5 as covalent complexes with imipenem, cloxacillin and cefoxitin. These antibiotics exhibit very different second order rates of acylation for the enzyme. In all three structures, there is excellent electron density for the central portion of the β lactam, but weak or absent density for the R1 or R2 side chains. Areas of contact between the antibiotics and PBP 5 do not correlate with the rates of acylation. The same is true for conformational changes because although shift of a loop leading to an electrostatic interaction between Arg248 and the β -lactam carboxylate, which occurs completely with cefoxitin, partially with imipenem and is absent with cloxacillin, is consistent with the different rates of acylation, mutagenesis of Arg248 only decreased cefoxitin acylation two fold. Together, these data suggest that structures of post-covalent complexes of PBP 5 are unlikely to be useful vehicles for design of new covalent inhibitors of PBPs. Finally, superimposition of the imipenem-acylated complex with PBP5 in complex with a boronic acid peptidemimetic shows that the position corresponding to the hydrolytic water molecule is occluded by the ring nitrogen of the β -lactam. Since the ring nitrogen occupies a similar position in all three complexes, this
18F- uorodeoxyglucose Positron Emission Tomography/computed Tomography Comparison of Gastric Lymphoma and Gastric Carcinoma

Qiaoling Xu A liated Hospital of Jiangnan University Najing Wu A liated Hospital of Jiangnan University Huihui He A liated Hospital of Jiangnan University Xiaoqing Du A liated Hospital of Jiangnan University Yanjuan Wang A liated Hospital of Jiangnan University Kequan Lou A liated Hospital of Jiangnan University Liping Chen A liated Hospital of Jiangnan University Yu Zhang A liated Hospital of Jiangnan University Chunjing Yu (  ycjwxd1978@jiangnan.edu.cn ) A liated Hospital of Jiangnan University
Link Detection Based on Named Entity Keywords in Turkish News Corpus

— In this study, we investigate the influence of Named Entities (NEs) on the task of Story Link Detection (SLD), which is one of the important subtasks in Topic Detection and Tracking (TDT). TDT aims at developing algorithms for either clustering documents, e.g., online news, and then tracking new ones with respect to a predetermined topic or otherwise detecting a new topic. Furthermore, SLD focuses on determining whether the stories are about the same topic. Vector Space Model (VSM) was used as a base method in this work for “All-words” and Named Entities (NE) separately. We also investigated the effect of controlled entity intersection on the performance of previous VSM based methods. Combining these methods provided improvement in correctly estinating whether the stories are linked or not.
A Framework for Robust, Low-Overhead Binary Instrumentation

—We have designed and implemented a binary rewriter called RL-Bin, which can rewrite binaries correctly with low overhead. Existing binary rewriters have their challenges: static rewriters do not reliably work for stripped binaries ( i . e ., those without relocation information), and dynamic rewriters suffer from high base overhead. Because of this high overhead, existing dynamic rewriters are limited to off-line testing, and cannot be used in deployment. RL-Bin differentiates itself from other binary rewriters by having the capability to robustly rewrite stripped binaries with very low overhead (averaging 1.05x for SPECrate 2017, not including the instrumentation cost, compared to 1.16x overhead for DynamoRIO). The overhead added by RL-Bin itself is negligible and it is proportional to the added instrumentation. Hence, lightweight instrumentation can be added to applications that are deployed in live systems for monitoring and analysis purposes.
Extraction and Registration of 3D Lines by Fusing Gradient Information and Neighboring Point Cloud Distribution

The traditional point-based scene reconstruction scheme always leads to inaccurate 3d reconstruction results due to its lack of scene texture and object occlusions. With the help of geometric characteristics and line features of 3d point cloud scenes, a novel extraction, matching and registration method of 3d line features is presented by fusing RGB gradient and the spatial distribution of neighboring point clouds. Firstly, the supporting region of 3d linear segments with similar gradient directions can be determined by scenes RGB image. Secondly, owing to the neighboring geometric features contained in the depth map, the point set of boundary lines and folded edge lines can also be extracted according to the spatial distribution of current point and its neighboring points. The 3d line features can thus be ﬁtted by these extracted point sets respectively. Thirdly, taking each extracted 3d line feature as central axis, the supporting region can be constructed as the co-axial cylinder with same thickness of each cylindrical layer. According to the 3d gradient statistics of point cloud within each cylindrical layer, we can calculate a intrinsic descriptor for each 3d line, which can be adopted to match 3d line features between scene frames. Finally, a novel line-to-line iterative closest line registration algorithm is introduced to compute the rotation and translation transformation, and the inter-frame point cloud scene data can be registered eﬃciently. Compared with the existing line feature extraction and point-based registration methods, our experimental results illustrate that the proposed line feature based scheme has high registration eﬃciency, less computational cost, accurate registration and also strong robustness.
Orbital and physical parameters of eclipsing binaries from the ASAS catalogue -- III. Two new low-mass systems with rapidly evolving spots

We present the results of our spectroscopic and photometric analysis of two newly discovered low-mass detached eclipsing binaries found in the All-Sky Automated Survey (ASAS) catalogue: ASAS J093814-0104.4 and ASAS J212954-5620.1. Using the GIRAFFE instrument on the 1.9-m Radcliffe telescope at SAAO and the UCLES spectrograph on the 3.9-m Anglo-Australian Telescope, we obtained high-resolution spectra of both objects and derived their radial velocities (RVs) at various orbital phases. The RVs of both objects were measured with the TODCOR technique using synthetic template spectra as references. We also obtained V and I band photometry using the 1.0-m Elizabeth telescope at SAAO and the 0.4-m PROMPT instruments located at the CTIO. The orbital and physical parameters of the systems were derived with PHOEBE and JKTEBOP codes. We compared our results with several sets of widely-used isochrones. Our multi-epoch photometric observations demonstrate that both objects show significant out-of-eclipse modulations, which vary in time. We believe that this effect is caused by stellar spots, which evolve on time scales of tens of days. For this reason, we constructed our models on the basis of photometric observations spanning short time scales (less than a month). Our modeling indicates that (1) ASAS-09 is a main sequence active system with nearly-twin components with masses of M1 = 0.771(33) Msun, M2 = 0.768(21) Msun and radii of R1 = 0.772(12) Rsun and R2 = 0.769(13) Rsun. (2) ASAS-21 is a main sequence active binary with component masses of M1 = 0.833(17) Msun, M2 = 0.703(13) Msun and radii of R1 = 0.845(12) Rsun and R2 = 0.718(17) Rsun. Both systems confirm the characteristic of active low-mass stars, for which the observed radii are larger and the temperatures lower than predicted by evolutionary models. Other parameters agree within errors with the models of main sequence stars.
Enhanced Heterogeneous Cross-Layer Protocol for Wireless Sensor Networks

Wireless Sensor Networks (WSN’s) life span improvement with minimum energy expenditure is the vital issue to address. Lifespan of WSN’s can improve with heterogeneous nodes compared to homogeneous nodes. This paper presents a novel MAC-ROUTE cross-layer technique named as Enhanced heterogeneous MAC-ROUTE Cross-Layer protocol. Proposed technique is dynamic in nature and energy efficient compare to existing protocols. The simulation is carried out using MATLAB and it is observed that proposed protocol is efficient than existing WSN routing protocols. The results show the improved stability duration, increased Packet Numbers transmitted to BS and prolonged network lifespan compare to existing protocols.
TWO CONGRUENCES CONCERNING APÉRY NUMBERS CONJECTURED BY Z.-W. SUN

Let n be a nonnegative integer. The n-th Apéry number is defined by An := n ∑ k=0 (n+ k k )2(n k )2 . Z. -W. Sun investigated the congruence properties of Apéry numbers and posed some conjectures. For example, Sun conjectured that for any prime p ≥ 7 p−1 ∑ k=0 (2k + 1)Ak ≡ p− 7 2 pHp−1 (mod p ) and for any prime p ≥ 5 p−1 ∑ k=0 (2k + 1)Ak ≡ p + 4pHp−1 + 6 5 pBp−5 (mod p ), where Hn = ∑n k=1 1/k denotes the n-th harmonic number and B0, B1, . are the well-known Bernoulli numbers. In this paper we shall confirm these two conjectures.
Toward an Assessment of Ocean Acidiﬁcation in the Adriatic Sea and Impacts on the Biogeochemistry of Marine Carbonate System

The increase of CO 2 amount in the atmosphere has created great concern: it will in all probability result in changes in temperature, precipitation and/or their seasonal amplitudes with consequences not only on sea level rise but also on chemical equilibrium of the CO 2 system in seawater, mainly reducing pH and carbonate ion concentration (Ocean Acidiﬁcation). The process is now well documented in ﬁeld data from all around the world. However is not sufﬁciently witnessed in the Mediter-reranean Sea, due to the scarcity of good quality data. On this concern, results for the Adriatic Sea are presented: from experimental measures of pH and total alkalinity, two seasonal pictures of pH and carbonate system parameters have been drawn. In addition, a pH decrease of 0.063 pH T units with related chemistry changes has been inferred in the North Adriatic Dense Water (NAdDW) over the two last decades. These results, although preliminary, merit attention as conﬁrm that N. A. sea has been affected by OA, being sensitive to the climate forcing. Potential impacts of OA are several and should be assessed, as many might even exacerbate hyopoxia/anoxia events, already affecting the area. OA might also affetc the food web, as the carbonate reduction has the potential to alter the distribution and abundance of marine organisms that use calcium carbonate to build their shells or skeletons (corals, plankton) and the organisms that depend on them for survival (ﬁshes, marine mammals).
Domaines fondamentaux des groupes arithmétiques

© Association des collaborateurs de Nicolas Bourbaki, 1964, tous droits réservés. L’accès aux archives du séminaire Bourbaki (http://www.bourbaki. ens.fr/) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
DIPSS co-investigators (2016). Digital interventions to promote self-management in adults with hypertension systematic review and meta-analysis. Journal of Hypertension , 34 (4), 600-612.

Objective: To synthesize the evidence for using interactive digital interventions (IDIs) to support patient self-management of hypertension, and to determine their impact on control and reduction of blood pressure. Method: Systematic review with meta-analysis was undertaken with a search performed in MEDLINE, EMBASE, CINAHL, PsycINFO, ERIC, Cochrane Library, DoPHER, TROPHI, Social Science Citation Index and Science Citation Index. The population was adults ( > 18 years) with hypertension, intervention was an IDI and the comparator was usual care. Primary outcomes were change in SBP and DBP. Only randomized controlled trials and studies published in journals and in English were eligible. Eligible IDIs included interventions accessed through a computer, smartphone or other hand-held device. Results: Four out of seven studies showed a significantly greater reduction for intervention compared to usual care for SBP, with no difference found for three. Overall, IDIs significantly reduced SBP, with the weighted mean difference being (cid:1) 3.74mmHg [95% confidence interval (CI) (cid:1) 2.19 to (cid:1) 2.58] with no heterogeneity observed (I-squared ¼ 0.0%, P ¼ 0.990). For DBP, four out of six studies indicated a greater reduction for intervention compared to controls, with no difference found for two. For DBP, a significant reduction of (cid:1) 2.37mmHg (95% CI (cid:1) 0.40 to (cid:1) 4.35) was found, but considerable heterogeneity was noted (I-squared ¼ 80.1%, P ¼ < 0.001). Conclusion: IDIs lower both SBP and DBP compared to usual care. Results suggest these findings can be applied to a wide range of healthcare systems and populations. However, sustainability and long-term clinical effectiveness of these interventions remain uncertain. socio-economic, smoking and comorbidities), intervention details (description, setting, duration, mean
A learning experience elicits sex-dependent neurogenomic responses in Bicyclus anynana butterflies

Sexually dimorphic behavior is pervasive across animals, with males and females exhibiting different mate selection, parental care, foraging, dispersal, and territorial strategies. However, the genetic underpinnings of sexually dimorphic behaviors are poorly understood. Here we investigate gene networks and expression patterns associated with sexually dimorphic imprinting-like learning in the butterfly Bicyclus anynana. In this species, both males and females learn visual preferences, but learn preferences for different traits and use different signals as salient, unconditioned cues. To identify genes and gene networks associated with this behavior, we examined gene expression profiles of the brains and eyes of male and female butterflies immediately post training and compared them to the same tissues of naïve individuals. We found more differentially expressed genes and a greater number of significant gene networks in the eye, indicating a role of the peripheral nervous system in visual imprinting-like learning. Females had higher chemoreceptor expression levels than males, supporting the hypothesized sexual dimorphic use of chemical cues during the learning process. In addition, genes that influence B. anynana wing patterns (sexual ornaments), such as invected, spalt, and apterous, were also differentially expressed in the brain and eye, suggesting that these genes may influence both sexual ornaments and the preferences for these ornaments. Our results indicate dynamic and sex-specific responses to social scenario in both the peripheral and central nervous systems and highlight the potential role of wing patterning genes in mate preference and learning across the Lepidoptera.
Nutritional depletion of total mixed rations by red-winged blackbirds and projected impacts on dairy cow performance

This Research Communication describes an investigation of the nutritional depletion of total mixed rations (TMR) by pest birds. We hypothesized that species-specific bird depredation of TMR can alter the nutritional composition of the ration and that these changes can negatively impact the performance of dairy cows. Blackbirds selected the high energy fraction of the TMR (i.e., flaked corn) and reduced starch, crude fat and total digestible nutrients during controlled feeding experiments. For Holsteins producing 37·1 kg of milk/d, dairy production modeling illustrated that total required net energy intake (NEI) was 35·8 Mcal/d. For the reference TMR unexposed to blackbirds and the blackbird-consumed TMR, NEI supplied was 41·2 and 37·8 Mcal/d, and the resulting energy balance was 5·4 and 2·0 Mcal/d, respectively. Thus, Holsteins fed the reference and blackbird-consumed TMR were estimated to gain one body condition score in 96 and 254 d, and experience daily weight change due to reserves of 1·1 and 0·4 kg/d, respectively. We discuss these results in context of an integrated pest management program for mitigating the depredation caused by pest birds at commercial dairies.
SOCIAL INFLUENCE AND DEPENDENCE IN THE FACEBOOK USE BY ROMANIAN AND LITHUANIAN UNIVERSITY STUDENTS

The time spent on Facebook by university students is continuously increasing. This fact is raising many questions as regards the relation between the social networking websites and the university. The educators are challenged to understand the factors that are driving the adoption of social networking websites, the characteristics of the daily use as well as the positive and negative effects on the university work. The social influence has been recognized as one of the factors that are driving the adoption of information systems. On another hand, the excessive use may lead to addiction. The first objective of this research is to explore the correlation between the social influence and the Facebook dependence. A model with these latent variables has been specified and tested on two samples of university students, the first from Romania and the second from Lithuania. The second objective of the research is to comparatively discuss the measures in each country. A multi-group confirmatory factor analysis has been carried on to test the configural and metric invariance. The comparison of means shows that university students reporting higher social influence have a higher risk of Facebook dependence. The comparative analysis revealed that for both variables, the mean values are higher for the Romanian sample.