Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes.

The effect of recombinant GH on strength, body composition and endocrine parameters in power athletes was investigated in a controlled study. Twenty-two healthy, non-obese males (age 23.4 +/- 0.5 years; ideal body weight 122 +/- 3.1%, body fat 10.1 +/- 1.0%; mean +/- SEM) were included. Probands were assigned in a double-blind manner to either GH treatment (0.09U (kg BW)-1 day-1 sc) or placebo for a period of six weeks. To exclude concurrent treatment with androgenic-anabolic steroids urine specimens were tested at regular intervals for these substances. Serum was assayed for GH, IGF-I, IGF-binding proteins, insulin and thyroxine before the onset of the study and at two-weekly intervals thereafter. Maximal voluntary strength of the biceps and quadriceps muscles was measured on a strength training apparatus. Fat mass and lean body mass were derived from measurements of skinfolds at ten sites with a caliper. For final evaluation only data of those 8 and 10 subjects in the two groups who completed the study were analyzed. GH, IGF-I and IGF-binding protein were in the normal range before therapy and increased significantly in the GH-treated group. Fasting insulin concentrations increased insignificantly and thyroxine levels decreased significantly in the GH-treated probands. There was no effect of GH treatment on maximal strength during concentric contraction of the biceps and quadriceps muscles. Body weight and body fat were not changed significantly during treatment. We conclude that the anabolic, lipolytic effect of GH therapy in adults depends on the degree of fat mass and GH deficiency. (ABSTRACT TRUNCATED AT 250 WORDS)
THE VALUE OF THE OSCILLATORY POTENTIAL IN SELECTING JUVENILE DIABETICS AT RISK OF DEVELOPING PROLIFERATIVE RETINOPATHY

A prospective long‐term study of the predictive value of the oscillatory potential in the development of proliferative diabetic retinopathy has been made in 137 diabetics. Follow‐ups 6–8 and 13–15 years later demonstrated that recording the oscillatory potential in juvenile diabetics with a disease duration of more than 5 years is valuable in selecting those at risk of developing proliferative retinopathy within 6 years at any rate. The predictive value of the oscillatory potential is probably more limited in women who later become pregnant.
Identification and characterization of a brilliant yellow pigment produced by Bordetella pertussis

Culture supernatants of Bordetella pertussis are a brilliant yellow; however, the structure and biological role of the responsible pigment have not been investigated. In this study, a brilliant yellow‐colored fraction was extracted from culture supernatants of B. pertussis and analyzed by HPLC. UV–visible spectral analysis and mass spectrometry identified the brilliant yellow pigment as riboflavin. Riboflavin production was high in lag and early log phases and riboflavin was found to enhance growth of B. pertussis in low‐density cultures. Riboflavin production is not regulated by the BvgAS system. In addition, it was found that other Bordetella species, such as B. parapertussis, B. holmesii and B. bronchiseptica, also release riboflavin into their culture supernatants. This is the first report that B. pertussis secrets riboflavin to the extracellular space and that riboflavin may promote its growth. The mechanism may be associated with pathogenesis of B. pertussis.
Low temperature FDSOI devices, a key enabling technology for 3D sequential integration

Processing a high performance transistor at temperature lower than 650°C is the main challenge of 3D sequential integration. This paper shows how FDSOI architecture enables to overcome the issues observed in bulk devices, i.e: higher junction leakage and deactivation and allow performance matching of low temperature devices with their high temperature counterparts.
The Insertion and Use of Radon in Cancer of the Œsophagus

remaining or distal side of the growth still to be dealt with, so the Souttar's tube was removed and in its place a fresh one was inserted, to the left side of which was strapped a line of four radon seeds, increasing the dose to 19 8 mc. (including the 14 4 already mentioned). The pleural cavity was mopped out with 1/1000 flavine, and the wound sutured without drainage. During the following month the patient ran a hectic temperature and eventually died (April 24, 1929), nearly five weeks after the t.horax was opened.
Streptomyces pini sp. nov., an actinomycete isolated from phylloplane of pine (Pinus sylvestris L.) needle-like leaves.

A novel siderophore-producing actinomycete, designated PL19T, was isolated from the Scots-pine needle-like leaves collected from TNAU campus, Coimbatore, India. The isolate was chemoorganotrophic in nutrition and able to grow at 30 °C, and the optimum pH and NaCl facilitated the growth pH 6-11 and 0-8 % (w/v), respectively. The cells are filamentous and the mycelia formed are basically of wide and intricately branched substrate mycelium from which aerial mycelia arises, later gets differentiated into spores that are warty and arranged spirally. The 16S rRNA gene of strain PL19T was sequenced and was highly similar to the type strains of species of the genus Streptomyces, including Streptomyces barkulensis RC1831T (98.8 % pairwise similarity), Streptomyces fenghuangensis GIMN4.003T (98.2 %), Streptomyces nanhaiensis SCSIO 01248T (98.0 %), Streptomyces radiopugnans R97T (97.9 %), Streptomyces atacamensis C60T (97.8 %) and Streptomyces macrosporus NBRC 14749T (97.2 %), all of which were subjected to taxonomical characterization using a polyphasic approach. The strains showed unique carbon utilization patterns, and it possesses iso-C16 : 0 anteiso-C15 : 0 and anteiso-C17 : 0 as a major cellular fatty acids. The cell-wall was dominated with ll-type diaminopimelic acid, and the menaquinone type was MK-9(H6, H8). These chemotaxonomic evidences placed strain PL19T within the genus Streptomyces. The determination of G+C ratio (69.5 mol%) and DNA-DNA hybridization values (13.4-31.8 % with the phylogenetically related species) helped in further hierarchical classification of strain PL19T. Based on morphological, physiological and chemotaxonomic data as well as DNA-DNA hybridization values, strain PL19T could be distinguished from the evolutionarily closest species currently available. All these collective data show that strain PL19T represents a novel species of the genus Streptomyces, for which the name Streptomyces pini sp. nov. is proposed. The type strain is PL19T (=NRRL B-24728T=ICMP 17783T).
Spider algorithm for clustering time series

In proportion to the rapid development of information technology, time series are today accumulated in finance, medicine, industry and so forth. Therefore, an analysis of them is an urgent need for these applications. As solving these problems clustering time series has much been paid attention. The similarity for the clustering is commonly measured with Euclidean distance and dynamic time warping. In this paper we propose an innovative and novel algorithm for clustering multivariate time series. The algorithm is called "Spider Algorithm". We experimentally show that the similarity from spider algorithm is superior to Euclidean distance or warping path on dynamic time warping, especially when many clusters exist.
GLUCOSTATIC MECHANISM OF REGULATION OF FOOD INTAKE

THE regulation of energy intake is fundamental to all homeostatic mechanisms. Yet this basic process has received less attention than many of the physiologic regulations that it makes possible. Before this century, three theories were advanced to account for the phenomenon of hunger. The theories of peripheral origin (Haller, Erasmus Darwin, Johannes Muller and Weber) held that the taking of food resulted from the stimulation either of all afferent nerves by some change in the tissues or of a strictly local group of sensory nerves, mainly in the stomach. The theory of central origin (Magendie, Tidewald and Milne-Edwards) postulated that .
Evaluating the Virtual Products for Online Games via the Grey Relational Analysis

Over the past years, researchers and practitioners in marketing fields have seen a dramatic growth of online games. This growth and development also influence playersâ€™ behavior and market change of hardware and software companies. This study proposes a model for selecting the optimal virtual products for online games by referring to the views of online players. The proposed model adopts the â€œmodified Delphi methodâ€ to find suitable evaluative criteria for virtual products, and then applies the â€œgrey relational analysis (GRA)â€ to rank the alternatives and select the best virtual products. In addition, the example of a renowned online game, MapleStory, is used to demonstrate the process of virtual products selection using this model. This model provides the online gamer an objective and effective way to select virtual products, and provides suggestions for the manufacturers of online games in regard to developing and improving the virtual products.
Properties of publications on anatomy in medical education literature

Publications on anatomy in medical education appear to be largely anecdotal. To explore this, we investigated the literature on anatomy in medical education, aiming first to evaluate the contribution of the literature on anatomy in medical education to “best evidence medical education” (BEME) and second to evaluate the development of this literature toward more “best evidence” between 1985 and 2009. Four databases were searched for publications on anatomy in medical education published between 1985 and 2009, resulting in 525 references. Hundred publications were characterized by five variables (journal category, paper subject, paper category, author perspective, and paper perspective). Statements from these publications were characterized by two variables (category and foundation). The publications contained 797 statements that involved the words “anatomy,” “anatomical,” or “anatomist. ” Forty‐five percent of the publications contained no explicit research question. Forty percent of the statements made were about “teaching methods” and 17% about “teaching content,” 8% referred to “practical value,” and 10% to “side effects” of anatomy education. Ten percent of the statements were “positional,” five percent “traditional,” four percent “self‐evident,” and two percent referred to “quality of care. ” Fifty‐six percent of the statements had no foundation, 17% were founded on empirical data, and 27% by references. These results substantiated the critical comments about the anecdotal nature of the literature. However, it is encouraging to see that between 1985 and 2009 the number of publications is rising that these publications increasingly focus on teaching methods and that an academic writing style is developing. This suggests a growing body of empirical literature about anatomy education. Anat Sci Educ 4: 105–114, 2011. © 2011 American Association of Anatomists
CT‐guided percutaneous lung biopsies in patients with haematologic malignancies and undiagnosed pulmonary lesions

We searched the electronic patient database at The University of Texas M. D. Anderson Cancer Center for patients who underwent computed tomography (CT)‐guided needle biopsy between January 2001 and December 2005. Inclusion criteria were a known history of haematologic malignancy and a newly detected, undiagnosed pulmonary lesion on chest CT that required tissue sampling for diagnosis; 213 met these criteria. We analysed the biopsy results for diagnostic yield, factors affecting diagnostic yield and effect on treatment. Of 213 procedures, 191 (89.7%) yielded sufficient material for pathologic analysis; 130 (60%) yielded specific diagnoses, while 61 (28.6%) yielded nonspecific benign diagnoses. Lesions larger than 1 cm, cavitary lesions and lung masses were more likely to yield a specific diagnosis than were lesions smaller than 1 cm, lung nodules and consolidations. The most common specific diagnoses were malignancy (62.8%) and infection (34.3%). The latter was more common in patients with leukaemia, cavitary lung lesions or consolidations, active underlying malignancy, neutropenia, respiratory signs and symptoms and/or fever, bone marrow transplant recipients, and in patients receiving chemotherapy. Lung lesions discovered upon follow‐up imaging in patients who did not have any respiratory signs/symptoms or fever were mostly malignant. Therapeutic changes were more likely after a specific diagnosis than after a nonspecific diagnosis or a nondiagnostic biopsy (88.4% vs. 18.1%; p < 0.0001). CT‐guided lung biopsy has a high diagnostic yield in patients with haematologic malignancies that present with unexplained pulmonary lesions and provides a specific diagnosis in a majority of these patients, leading to therapeutic changes. Copyright © 2009 John Wiley & Sons, Ltd.
Loss of RAB 25 expression in breast cancer

A novel breast cancer cell line (RAO-3) was established by transduction of the Q61L mutant RAS into human mammary epithelial cells that were immortalized with catalytic subunit of telomerase (hTERT). The cells displayed anchorage-independent growth and proliferation, and formed human mammary spindle cell carcinoma when injected into nude mice. Chromosome locus 1q22-23 was partially duplicated and inverted on one of the 3 chromosomes present in the cell line. We report here that mutations of chromosome 1q22-23 locus have resulted in the loss of RAB25 expression in the breast cancer cell line. Transduction of RAB25 into the breast cancer cell line arrests anchorage-independent growth. We have also demonstrated loss of RAB25 in human breast tumor tissue. These data suggest that loss of RAB25 might contribute to tumorigenesis of breast cancer, and RAB25 is likely to be an important factor in the development of breast cancer. RAB25 could be used as biological marker of breast cancer and provides a target for gene replacement therapy. ' 2006 Wiley-Liss, Inc.
ARF6 and GASP‐1 are post‐endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D2 receptors mediated by GRK and PKC in transfected cells

GPCRs undergo both homologous and heterologous regulatory processes in which receptor phosphorylation plays a critical role. The protein kinases responsible for each pathway are well established; however, other molecular details that characterize each pathway remain unclear. In this study, the molecular mechanisms that determine the differences in the functional roles and intracellular trafficking between homologous and PKC‐mediated heterologous internalization pathways for the dopamine D2 receptor were investigated.
Update of staging and risk assessment for prostate cancer patients

Purpose of review This paper will review the current staging system for prostate adenocarcinoma patients, and will also review new information that can be combined with clinical and pathological staging in order to assess a patient's risk of success or failure of treatment. Recent findings There has been significant stage migration of prostate cancer patients in the past 15 years, such that patients are currently being diagnosed younger, with lower clinical stages and serum prostate-specific antigen levels, and a lower risk of metastatic disease than previously. The incorporation of the results of extended prostate biopsy schemes, with stage, grade and serum prostate-specific antigen levels, improves the risk assessment of newly diagnosed prostate cancer patients. New imaging techniques, such as transrectal ultrasound Doppler flow and magnetic resonance spectroscopy hold promise for improving risk assessment. Molecular biomarkers may improve risk assessment in the future, although none are currently approved by the US Food and Drug Administration for this indication. Gene chip arrays may further refine risk assessment and assist with the identification of therapeutic targets. Summary There has been significant stage migration of prostate cancer patients in the prostate-specific antigen era. Incorporating biopsy information into nomograms and risk assessment equations improves upon clinical staging and risk assessment. New imaging techniques, molecular markers and gene chip arrays hold promise for future risk assessment.
Efficient binary and grey level morphological operations on a massively parallel processor

One of the most important features in image analysis and understanding is shape. Mathematical morphology is the image processing branch that deals with shape analysis. The definition of all morphological transformations is based on two primitive operations, i.e. dilation and erosion. Since many applications require the solution of morphological problems in real time, researching time efficient algorithms for these two operations is crucial. †The implementation of the above functions is beyond the scope of this paper. In this paper, efficient algorithms for the binary as well as the grey level dilation and erosion are presented and evaluated for an advanced associative processor. It is shown through simulation results that the above architecture is near optimal in the binary case and is also as efficient as the array processor with a 2D-mesh interconnection in the grey level case. Finally, it is proven that the implementation of this image processing machine is economically feasible.
High Critical Temperature Superconducting Wire Based Flux Transformers

Flux transformers are currently used for signal detection with high sensitivity magnetometers like SQUIDS , as an alternative to direct coupling between the magnetometer and the sample. To avoid extra noise, most of them are made of superconducting material, namely low critical temperature (Tc) wires and high Tc thin films. We build flux transformers with high Tc Bi-2223 commercial wires operating at 77 K. Because the loops are closed by tin soldering, the device has a residual resistance of a few muOmega . We present the magnetic flux transfer characteristics and the calculations of the noise induced in the detection chain by this kind of flux transformer in two configurations: the untuned flux transformer and the tuned flux transformer.
Development and characterization of a dynamic lesion phantom for the quantitative evaluation of dynamic contrast-enhanced MRI.

PURPOSE To develop a dynamic lesion phantom that is capable of producing physiological kinetic curves representative of those seen in human dynamic contrast-enhanced MRI (DCE-MRI) data. The objective of this phantom is to provide a platform for the quantitative comparison of DCE-MRI protocols to aid in the standardization and optimization of breast DCE-MRI. METHODS The dynamic lesion consists of a hollow, plastic mold with inlet and outlet tubes to allow flow of a contrast agent solution through the lesion over time. Border shape of the lesion can be controlled using the lesion mold production method. The configuration of the inlet and outlet tubes was determined using fluid transfer simulations. The total fluid flow rate was determined using x-ray images of the lesion for four different flow rates (0.25, 0.5, 1.0, and 1.5 ml/s) to evaluate the resultant kinetic curve shape and homogeneity of the contrast agent distribution in the dynamic lesion. High spatial and temporal resolution x-ray measurements were used to estimate the true kinetic curve behavior in the dynamic lesion for benign and malignant example curves. DCE-MRI example data were acquired of the dynamic phantom using a clinical protocol. RESULTS The optimal inlet and outlet tube configuration for the lesion molds was two inlet molds separated by 30° and a single outlet tube directly between the two inlet tubes. X-ray measurements indicated that 1.0 ml/s was an appropriate total fluid flow rate and provided truth for comparison with MRI data of kinetic curves representative of benign and malignant lesions. DCE-MRI data demonstrated the ability of the phantom to produce realistic kinetic curves. CONCLUSIONS The authors have constructed a dynamic lesion phantom, demonstrated its ability to produce physiological kinetic curves, and provided estimations of its true kinetic curve behavior. This lesion phantom provides a tool for the quantitative evaluation of DCE-MRI protocols, which may lead to improved discrimination of breast cancer lesions.
Face photo recognition using sketch

Automatic retrieval of face images from police mug-shot databases is critically important for law enforcement agencies. It can help investigators to locate or narrow down potential suspects efficiently. However, in many cases, the photo image of a suspect is not available and the best substitute is often a sketch drawing based on the recollection of an eyewitness. We present a novel photo retrieval system using face sketches. By transforming a photo image into a sketch, we reduce the difference between photo and sketch significantly, thus allowing effective matching between the two. Experiments over a data set containing 188 people clearly demonstrate the efficacy of the algorithm.
Comparison of video‐assisted minithoracotomy and standard open thoracotomy for the treatment of non‐small cell lung cancer

This study represents a retrospective comparison of video‐assisted thoracic surgery (VATS) lobectomy with standard open lobectomy for non‐small cell lung cancer (NSCLC). The endpoints of this study include surgical stress as measured by interleukin 6 concentration and patient survival. A retrospective review was performed of 240 consecutive patients with clinical stage IA or IB NSCLC who underwent either VATS lobectomy (n = 67) or conventional open lobectomy (n = 173). The amount of blood loss was significantly less in the VATS group (110±75 ml) as compared to 165±90 ml for the open lobectomy group (P<0.05). A significantly lower incidence of postthoracotomy pain occurred in the VATS group (6.2±4.1 times/3days) than in the open lobectomy group (13.5±5.8 times/3 days, P<0.0001). The postoperative interleukin (IL)‐6 serum concentration of was significantly lower in the VATS group (112±43 pg/ml) than that in the open lobectomy group (351±133 pg/ml, P<0.001). There was no statistically significant difference in survival between the VATS and open lobectomy groups. The median follow‐up was 42 months in both groups. VATS lobectomy for NSCLC is a reasonable treatment option for selected patients with stage I NSCLC.