Miracle-dz/UniFAR-FTUs huggingface dataset:
Antimicrobial and enzymatic activity of actinomycetes isolated from soils of coastal islands

Microbiological investigation of unexplored ecosystems is crucial for discovering of antibiotic producing actinomycetes. The present study was conducted to determine antimicrobial activity and identify the most active strains. Actinomycetes were isolated using the spread plate technique following by serial dilution of samples on starch casein agar. The screening method consists of primary and secondary testing. The most active isolates were identified based on molecular and cultural methods. 42 out of 66 isolates displayed antimicrobial potential. 63% exhibited antibacterial activity, 16% antifungal activity, and 16% displayed both activities. Identified isolates, Streptomyces scabrisporus, Streptomyces sparsogenes, Streptomyces misakiensis, Streptomyces cirratus, Streptomyces lincolnensis, Streptomyces endophyticus, Streptomyces chartreusis, and Streptomyces alboniger showed a broad spectrum of enzymatic activities. The results indicated that these isolates may serve as antibiotic and enzyme-producing microbes.
Managing Inventory and Supply Performance in Assembly Systems with Random Supply Capacity and Demand

We consider stock positioning in a pure assembly system controlled using installation base-stock policies. When component suppliers have random capacity and end-product demand is uncertain, we characterize the system's inventory dynamics. We show that components and the end product play convex complementary roles in providing customer service. We propose a decomposition approach that uses an internal service level to independently determine near-optimal stock levels for each component. Compared with the optimal, the average error of the decomposition approach is 0.66% across the tested instances. Compared with current practice, this approach has the potential to reduce the safety-stock cost by as much as 30%. Our computational analysis on two-echelon systems also illustrates several managerial insights: We observe that the cost reduction from improving supply performance is high when demand variability or the number of components or target customer service is high, or when the end product is more expensive relative to components. On average, (i) reducing the lead time of the more expensive component yielded higher benefit than reducing the lead time for the less expensive component, and (ii) the benefit of improving one of the supply parameters (service level or lead time) was higher when the value of the other parameter was already more favorable (lower lead time or higher service level, respectively). Finally, we analytically show how a multi-echelon pure assembly system may be converted into an equivalent two-echelon assembly system to which all our results apply.
Just-in-time expression of influential genes in the cellular networks of the malaria parasite Plasmodium falciparum during the red blood cycle

Malaria remains one of the most important public health concerns worldwide. It causes nearly half a million deaths every year, and about 40% of the world's population lives in the endemic regions of malaria. A major hurdle in antimalarial development is our limited understanding of the dynamic cellular networks in the malaria parasite. In this study, by coupling RNA-Seq analysis and network mining using a PageRank-based algorithm, we investigated the temporal-specific expression of parasite genes during the 48-hour red blood cycle, and identified genes that may play influential roles in parasite development and invasion. The just-in-time mechanism for gene expression may contribute to a dynamic yet effective adaptive strategy of the malaria parasite.
Risk adapted high-dose and dose-dense therapies modulate the impact of biological classification in diffuse large B-cell lymphoma prognosis

Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous disease entity. [1][1] Young patients with high-intermediate and high aa-IPI score seem to be good candidates to receive alternative treatments to standard RCHOP-21 including EPOCH-R,[2][2] R-ACVBP+HDT-ASCT[3][3] and upfront autologous
Treatment Effects of Antidepressants in Patients with Post-Stroke Depression: A Meta-Analysis

Background: Appropriate treatment of post-stroke depression (PSD) is critically important, considering the negative impact of PSD. Data regarding the treatment efficacy of antidepressants in patients with PSD are conflicting, and the time-dependent effects of antidepressant treatment in this population are unknown. Objective: To systematically assess treatment effects of antidepressants in patients with PSD, incorporating data from recent studies. Methods: A meta-analysis of randomized placebo-controlled trials (RCTs) of antidepressants in patients with PSD was conducted, using published studies from 1984 to 2006. Outcome measures of antidepressant treatment included response rate, depression rating scale scores, recovery of neurologic impairments, and improvements in activities of daily living (ADLs) after stroke. The effect size was presented as rate difference (RD) and weighted mean difference for dichotomous outcomes and continuous outcomes, respectively. Pooled effect sizes were calculated by both fixed-effects and random-effects models. Results: A total of 1320 patients who met inclusion criteria were identified from 16 RCTs. The pooled response rates in the active and placebo groups were 65.18% (234/359) and 44.37% (138/311), respectively. The pooled RD was 0.23 (95% CI 0.03 to 0.43), indicating a significantly higher response rate in the active group compared with the placebo group. From baseline to endpoint, patients in the active group had significantly greater improvement in depressive symptoms compared with patients in the placebo group. Longer duration of treatment was positively correlated with the degree of improvement in depressive symptoms (Spearman's correlation, [ρ] = -0.93, p = 0.001). No consistent evidence was found for positive antidepressant effects on the recovery of neurologic impairments and improvements in ADLs. Conclusions: The results of this meta-analysis suggest that use of antidepressants among patients with a diagnosis of PSD is associated with improvement in depressive symptoms. Longer durations of antidepressant treatment may be associated with greater reductions in depressive symptoms.
The 89,000-Mr murine cytomegalovirus immediate-early protein stimulates c-fos expression and cellular DNA synthesis

The immediate-early (IE) genes of murine cytomegalovirus (MCMV) are expressed in the absence of prior viral protein synthesis and regulate the transcription of MCMV early genes. The effect of MCMV IE genes on growth induction was studied. Different plasmids containing MCMV IE genes were microinjected into arrested NIH 3T3 mouse fibroblasts. Plasmids containing the ieI gene coding for the 89,000-Mr major IE protein pp89 were found to stimulate the expression of the c-fos protooncogene. Synthesis of pp89 and its transport to the nucleus appeared to be required for c-fos expression. DNA synthesis occurred in cells that were injected with MCMV IE genes and in neighboring cells that were not injected. The results suggest that the phosphoprotein pp89 stimulates cells to enter the cell cycle.
Monitoring of Abnormal Score in Provincial Academic Degrees Dissertation and Thesis through Double-Blind Review: A Case on Shanghai

Aimed at abnormal score from evaluation experts, real data from Shanghai double-blind sampling system of graduate dissertation and thesis between 2013 and 2014 have been in depth analysis and mining. Some basic judgment rules of abnormal score are summed up, and monitoring model for abnormal score is proposed. By the least squares method and the multiple regression models, the equation of monitoring model for abnormal score is constructed. Finally, the abnormal monitoring coefficient of five evaluation indicators on dissertation and thesis, including topic selection, innovativeness, academic nature, applicability and accuracy, are generated by real data from Shanghai double-blind sampling system of graduate dissertation and thesis between 2013 and 2014. The goodness fit test of error range constant on monitoring model for abnormal score is operated by real data from double-blind review on graduate dissertation of Master of Engineering in Shanghai Jiao Tong University between 2013 and 2014. It is strengthened the association between items and sub-items of double-blind review, and provided effective data resource for Shanghai Degree & Graduate Education Informatization Platform to construct a re-evaluation system.
An all-digital bang-bang PLL using two-point modulation and background gain calibration for spread spectrum clock generation

An all-digital spread spectrum clock generator (SSCG) using two-point modulation is presented. To calibrate the gain mismatch between two modulation paths, a background gain calibration method is proposed. To reduce power consumption and design complexity, the bang-bang phase-frequency detector (BBPFD) is used instead of the time-to-digital converter (TDC). The prototype chip has been fabricated in a 65-nm CMOS process and it consumes 6 mW at 2.5 GHz. The measured minimum rms jitter is 1.58 ps.
Evaluation of Genetic Diversity Within and Between Native and Khaki Campbell Duck breeds Using RAPD Markers

A total of 100 genomic DNAs were isolated from two breeds of duck: Khaki Campbell and Native , through a modified salting out procedure. The samples were used in a Polymerase Chain Reaction (PCR) with 27 RAPD Markers. Amplified PCR-products with the markers were separated on a 2% agarose gel and stained with ethidium bromide. To evaluate the bands , polymorphic and monomorphic bands were described. The RAPD analysis data from 5 primers were utilized in estimating genetic diversity and genetic distance. The genetic distance between two population was 36/06. The genetic diversity within Native and Khaki Campbell breeds was 51/08 and 66/01 respectively.
Comparative Analysis of Human and Canine Campylobacter upsaliensis Isolates by Amplified Fragment Length Polymorphism

ABSTRACT Human (n = 33) and canine (n = 53) Campylobacter upsaliensis isolates from seven countries were genotyped by a new amplified fragment length polymorphism method. We observed 100% typeability and high overall diversity. The majority of human strains (23/33) clustered separately from canine strains, indicating that dogs may not be the main source of human infection.
Measurement of the Weibo Hall of Fame Network

Weibo, a micro-blogging service provided by Sina at Sep. 2009, attracts over a hundred million users and is growing fast. Though Weibo user publishes any topic within the 140-character limit and follows others to receive their statuses as Twitter user does, Weibo differs from Twitter in many aspects, among which the Hall of Fame (HOF) is one of the most unique character of Weibo. Users in the HOF are all verified and recommended by Weibo, and they are the most popular and representative users. Research on the structure of HOF network can help understanding what Weibo is like and how users connect each other. We have crawled the entire HOF network and obtained 37 thousand user profiles and 3.49 million social relations. In its follower-following topology analysis we have found a power-law follower and following distribution, low reciprocity ratio, short diameter, homophile but no rich club phenomenon between users. Our finding shows that the Weibo HOF is not like online social networks or media websites. The relationship between Weibo users is much looser than online social networks, and all responses to any user's status can be better tracked by social relations than media websites. Weibo focuses on both content and relation, and can be regard as a social media. To the best of our knowledge, our work is the first quantitative experimental study on the Weibo HOF network.
Stability and Stabilization of Discrete-Time Semi-Markov Jump Linear Systems via Semi-Markov Kernel Approach

This technical note is concerned with the problems of stability and stabilization for a class of discrete-time semi-Markov jump linear systems (S-MJLSs). The discrete-time semi-Markov kernel (SMK) is introduced, where the probability density function of sojourn-time is dependent on both current and next system mode. As a consequence, different types of distributions and/or different parameters in a same type of distribution of sojourn-time, depending on the target mode towards which the system jumps, can coexist in each mode of a SMK. The underlying S-MJLSs are therefore more general than those considered in existing studies. A new stability concept generalizing the traditional mean-square stability is proposed such that numerically testable criteria on the basis of SMK are obtained. Numerical examples are presented to illustrate the validity and advantage of the developed theoretical results.
Micro-magnetic simulations on the switching of EF-controlled MTJ free layer magnetization assisted by oersted-field

We investigate the switching of electric-field (EF)-controlled magnetic tunneling junction free layer (FL) magnetization assisted by Oersted field using OOMMF (Object Oriented Micro Magnetics Framework). The effects of several physical parameters, such as damping constant, magnetic anisotropy, as well as the EF efficiency and the applied Oersted field on the switching of the free layer magnetization are examined. The results show that besides the damping constant, the EF efficiency and the applied Oersted field are also crucial parameters that may affect the switching speed. The switching time is mainly determined by the time that the easy axis of the free layer turns into in-plane due to the demagnetization field after applying EF.
You Are Not Alone

A low ability to self-regulate emotions (state orientation) is associated with reduced well-being—especially under stress. Until now, research has approached this topic from an asocial perspective that views the self as devoid from relatedness concerns. However, people are social creatures who benefit from their relationships with others. As such, we expected that personally valuing (Study 1) and experimentally priming (Study 2) a sense of relatedness with others would act as a buffer against stress-related impairments in state-oriented individuals. In Study 1, high (vs. low) benevolence values removed the adverse effect of state orientation on well-being found under stressful life circumstances. In Study 2, focusing on similarities (vs. differences) while comparing oneself with a friend removed the adverse effect of state orientation on recovery from a negative mood induction. Our findings suggest that individuals with low self-regulatory competencies may profit from valuing and directing their attention toward their relatedness with others.
Draft Genome Sequence of Ustilago trichophora RK089, a Promising Malic Acid Producer

ABSTRACT The basidiomycetous smut fungus Ustilago trichophora RK089 produces malate from glycerol. De novo genome sequencing revealed a 20.7-Mbp genome (301 gap-closed contigs, 246 scaffolds). A comparison to the genome of Ustilago maydis 521 revealed all essential genes for malate production from glycerol contributing to metabolic engineering for improving malate production.
A new approach to position reconstruction in TOFPET

Monte Carlo Simulation (MCS) is a state-of-the-art technique in designing sophisticated apparatus for various applications in science and technology. We adopted MCS based on GEANT (GEometry ANd Tracking) in order to design a simple time-of-flight positron emission tomography (TOFPET). In MCS studies, a new method of position reconstruction of positron-electron annihilation points has been developed so far. Simulation results show that this technique may not be useful for small animal imaging camera but might be practicable in diagnostic TOFPET camera. Specific issue of this simulation technique is discussed.
Adapted Transfer of Distance Measures for Quantitative Structure-Activity Relationships and Data-Driven Selection of Source Datasets

Quantitative structure–activity relationships are regression models relating chemical structure to biological activity. Such models allow to make predictions for toxicologically relevant endpoints, which constitute the target outcomes of experiments. The task is often tackled by instance-based methods, which are all based on the notion of chemical (dis-)similarity. Our starting point is the observation by Raymond and Willett that the two families of chemical distance measures, fingerprint-based and maximum common subgraph-based measures, provide orthogonal information about chemical similarity. This paper presents a novel method for finding suitable combinations of them, called adapted transfer, which adapts a distance measure learned on another, related dataset to a given dataset. Adapted transfer thus combines distance learning and transfer learning in a novel manner. In our experiments, we visualize the performance of the methods by learning curves and present a quantitative comparison for 10 and 100% of the maximum training set size to show that transfer exploiting source datasets is effective with small training datasets. Additionally, we present an approach to select the source task in a data-driven manner. The relevant experiments include an example that shows that the selection of a meaningful source task is a critical factor for transfer learning.
InGaAs-GaAs 980-nm stripe-geometry and circular ring ridge waveguide lasers fabricated with pulsed anodic oxidation

In/sub 0.22/Ga/sub 0.78/As-GaAs quantum-well stripe-geometry and circular ring lasers have been fabricated with pulsed anodic oxidation (PAO). The relationship between ridge heights and laser performance was first studied in the fabrication of stripe lasers. The lowest transparency current density (J/sub tr/) of 61.20 A/cm/sup 2/ was obtained from the stripe laser with a ridge height of 1.23 /spl mu/m, corresponding to an etching depth where all the p-doped layers above active region were removed. With the PAO process, when the ridge height (1.77 /spl mu/m) extended below the active region, J/sub tr/ is 76.03 A/cm/sup 2/, only increased by 24.2%. Based on the experimental results, the circular ring laser, which needs deep etching (below active region) and subsequent PAO, has been fabricated. The fabricated circular ring laser worked under continuous-wave operation at room temperature. Longitudinal mode spacing analysis clearly indicates that the ring resonator is a functional part of the whole circular ring laser.
Design and characterization of micromachined piezoelectric acoustic flexural plate wave devices

This paper presents a comparison of several piezoelectrically driven MEMS flexural plate wave (FPW) resonators, all with the electrical interfacing located on the top of the device and fully isolated from the fluidic interface and detection surface on the back of the device, in order to avoid mutual interference. The devices to be compared include devices designed to have wavelengths of 60μm and 100μm, and devices with and without a reflector grating. In general, the measured antisymmetric AO and symmetric SO modes of the devices in vacuum and air match well with values predicted by both analytical models and finite element analysis. The theoretical mass sensitivity of the FPWs is calculated to be 214.6cm2/g and is compared to an experimentally determined mass sensitivity for multiple modes.
Evidence of an equimolar C2H2-CO2 reaction in the synthesis of carbon nanotubes.

Keywords: carbon ; chemical vapor deposition ; heterogeneous catalysis ; nanotubes Note: ISSN 1433-7851 Reference LNNME-ARTICLE-2007-026doi:10.1002/anie.200603764View record in Web of Science Record created on 2007-08-31, modified on 2016-08-08
Adaptation and Initial Validation of the German Version of the Students’ Life Satisfaction Scale (German SLSS)

The present research describes the adaptation and initial validation of a brief measure of global life satisfaction, the Students’ Life Satisfactions Scale (SLSS), for German-speaking children and adolescents aged 10–17 years. Study 1 investigated the responses of 286 Swiss students (aged 12–17 years) administering paper-pencil questionnaires (e.g., Junior Eysenck Personality Questionnaire) during class on two occasions (interval 4 months). Study 2 investigated the responses of a heterogeneous sample composed of 3,407 Austrian, German, and Swiss students (aged 10–17 years), administering questionnaires online (e.g., Brief Multidimensional Students’ Life Satisfaction Scale). The German SLSS showed unidimensionality, explaining approximately 60% of variance, an internal consistency coefficient of α = . 88, and a stability coefficient of . 55 over a 4-month interval. Study 1 found a moderate association between life satisfaction and social desirability (.20), and theoretically meaningful correlations with temp.
Making sense of HIV stigma: Representations in young Africans’ HIV-related narratives

In addition to undermining the quality of life of those infected and affected by HIV, HIV-related stigma impedes access to prevention and treatment services, thereby threatening to erode the promise of recent advances in these areas. This paper provides insights into the socio-contextual and sense-making processes that inform HIV stigma through an innovative form of empirical data: creative fictional narratives written by young Africans (aged 10–24) for an HIV-themed scriptwriting competition. From a sample of 586 narratives from six sub-Saharan countries, we selected for illustrative purposes three on account of the complexity of their representation of HIV stigma. We conducted a close reading of each, using stigma theory as a lens. Through their explicit accounts of stigmatising attitudes and behaviours of characters and through implicit contradictions, tensions and ambivalence in their messaging, the narratives provide insights into the symbolic and social processes that create and sustain HIV stigma. Our analysis illuminates the authors’ struggles to navigate the cultural resources available to them in their efforts to make sense of HIV, gender and sexuality. It highlights some limitations of current communication efforts and the potential for narrative-based communication approaches to engage with representations that devalue women and people living with HIV.
Prenatal diagnosis of Machado–Joseph disease by direct mutation analysis

MJD is the most frequent dominant ataxia and an incapacitating disorder. Onset is most frequently during the reproductive years, and genetic counselling is its only means of prevention. The causative mutation—an expansion of a (CAG)n on chromosome 14q32.1—can now be directly detected. We now report the first two cases of prenatal diagnosis (PND).
Selective Attention to Signs of Success: Social Dominance and Early Stage Interpersonal Perception

Results from two experiments suggest that observers selectively attend to male, but not female, targets displaying signs of social dominance. Participants overestimated the frequency of dominant men in rapidly presented stimulus arrays (Study 1) and visually fixated on dominant men in an eyetracking experiment (Study 2). When viewing female targets, participants attended to signs of physical attractiveness rather than social dominance. Findings fit with evolutionary models of mating, which imply that dominance and physical attractiveness sometimes tend to be prioritized preferentially in judgments of men versus women, respectively. Findings suggest that sex differences in human mating are observed not only at the level of overt mating preferences and choices but also at early stages of interpersonal perception. This research demonstrates the utility of examining early-in-the-stream social cognition through the functionalist lens of adaptationist thinking.