Miracle-dz/UniFAR-FTUs huggingface dataset:
Measurements of renal shear wave velocities in chronic kidney disease patients

Background Chronic kidney disease (CKD) patients have advanced glomerulosclerosis and renal interstitial fibrosis. Shear wave elastography (SWE) is useful to diagnose liver fibrosis. However, there are few data available regarding evaluation of kidney function on the use of SWE. Purpose To assess the utility of SWE by evaluating the correlation between renal function and renal elasticity using SWE. Material and Methods A total of 187 participants who had available serum creatinine levels and also underwent SWE of the kidney using a transabdominal ultrasonography were recruited at Nagoya University Hospital. We measured the depth of the shear wave (SW) in the right and left kidneys and calculated the measurement success rates. The glomerular filtration rate (GFR) classification and shear wave value (SWV) were compared. Results The success rates of the right and left kidneys were 93.6% and 71.6%, respectively. Based on these results, the correlation between GFR classification and SWV were analyzed in only the right kidneys because the success rates and the number of enrolled patients were low for the left kidney. There were significant differences found between G1 and G3a, G2 and G3a, G3a and G3b, G3a and G4, and G3a and G5. SWV significantly negatively and positively correlated with the G2–G3a and G3a–G3b classifications. Conclusion There is no correlation between renal function and SW. However, we can diagnose the progression to the CKD stages G3a and G3b by observing the changes over time using the SWV.
GROUP-BASED PARENT TRAINING FOR PREVENTING MENTAL HEALTH DISORDERS IN CHILDREN

Conduct problems in preschool children are a significant mental health problem associated with later psychosocial and psychiatric disorders, pointing to the need for effective community-based preventive interventions with families of young children at risk. Group-based parent training has been described as one such intervention. This paper presents the nature of conduct problems in young children, the role of day care and preschools in gaining access to young children at risk, the theory and research underlying group-based parent training as one type of effective prevention strategy, and characteristics of effective parent training programs. Examples from the authors' experiences implementing parent training in day care centers in Chicago are presented.
Low-Barrier Nanomagnets as p-Bits for Spin Logic

It has recently been shown that a suitably interconnected network of tunable telegraphic noise generators or “p-bits” can be used to perform even precise arithmetic functions like a 32-bit adder. In this letter, we use simulations based on the stochastic Landau–Lifshitz–Gilbert (sLLG) equation to demonstrate that similar impressive functions can be performed using unstable nanomagnets with energy barriers as low as a fraction of a kT. This is surprising because the magnetization of low-barrier nanomagnets is not telegraphic with discrete values of <inline-formula><tex-math notation="LaTeX">$\pm 1$</tex-math></inline-formula>. Rather, it fluctuates randomly among all values between <inline-formula><tex-math notation="LaTeX">$-$</tex-math></inline-formula>1 and +1, and the output magnets are read with a thresholding device that translates all positive values to one and all negative values to zero. We present sLLG-based simulations demonstrating the operation of a 32-bit adder, with a network of several hundred nanomagnets, exhibiting a remarkably precise correlation: The input magnets {<italic>A</italic>} and { <italic>B</italic>} as well as the output magnets {<italic>S</italic>} all fluctuate randomly and yet the quantity <inline-formula><tex-math notation="LaTeX">$A+B$</tex-math></inline-formula><inline-formula><tex-math notation="LaTeX"> $-$</tex-math></inline-formula><inline-formula><tex-math notation="LaTeX">$S$</tex-math></inline-formula> is sharply peaked around zero! If we fix {<italic>A</italic>} and {<italic>B</italic>}, the sum magnets {<italic>S</italic>} rapidly converge to a unique state with <inline-formula><tex-math notation="LaTeX">$S=A+B$</tex-math></inline-formula> so that the system acts as an adder. But unlike standard adders, the operation is invertible. If we fix {<italic>S </italic>} and {<italic>B</italic>}, the remaining magnets {<italic>A</italic>} converge to the difference <inline-formula><tex-math notation="LaTeX">$A=S-B$</tex-math></inline-formula>. These examples emphasize a new direction for the field of nanomagnetics away from stable high-barrier magnets toward stochastic low-barrier magnets that not only operate with lower currents, but are also more promising for continued downscaling.
A Trust Enhanced Routing Model for Secured Ad Hoc On-demand Distance Routing Vector

Mobile ad hoc networks (MANETs) represent complex distributed systems that form stand-alone groups of wireless terminals. Although the principle of wireless, structure-less and dynamic networks is attractive, there are still some major security flaws that prevent commercial expansion. Most of the solutions proposed are based on cryptographic implementations which are immune only to specific type of threats and introduces significant routing overheads. Introducing a trust management procedure in a protocol that provides encryption procedures to authenticate messages and hash functions to protect mutable fields increases the capability of the network to address security threats. This paper presents a modified approach for Ad-hoc On-demand Distance Vector (AODV) protocol to implement trust model together with cryptographic features. A proactive table driven approach is proposed to create a trust table in each node and routing packet flow is restricted only to nodes with certain trust values which enhances routing efficiency. Inclusion of trust model aims to identify the misbehaving nodes based on their behaviours and isolate them from the network. This mechanism offers more resilience to attack from malicious nodes, while also promotes collaboration among cooperative nodes and penalizes selfish nodes.
CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression

Loss of major histocompatibility complex class II (MHCII) gene expression was associated with poor outcome in diffuse large B-cell lymphoma (DLBCL) in several studies. [1][1]–[3][2] The mechanism for lost expression is unknown. MHCII gene expression is controlled by several transcription factors,
Halved Vivaldi Antenna With Reconfigurable Band Rejection

This letter presents a Vivaldi antenna having the capability of dynamically rejecting interferers, mainly aiming at multistandard communication with dynamic frequencies allocation. Only half of the Vivaldi is used and placed over a ground plane, which is suitable to vehicular communication. The rejection Alter is integrated to the antenna real estate and consists of two microstrip resonators and two varactor diodes coupled to the slot of the Vivaldi. It is simply biased by applying the control voltage at the antenna RF port. Good matching is achieved from 2.5 to 8 GHz while rejecting a band whose central frequency can be tuned from 1.8 to 5.8 GHz. Simulated and measured return loss, gain, and radiation patterns are presented. The measured gain rejection in the direction of the radiation maximum is about 20 dB or better in the entire tuning range.
Clinical performance of multiplex high‐risk e6 mrna expression in comparison with hpv dna subtypes for the identification of women at risk of cervical cancer

We compared multiplex E6 messenger ribonucleic acid (mRNA) tests using real‐time quantitative reverse transcriptase polymerase chain reactions (PCR) with human papillomavirus (HPV) DNA subtypes using a MY11/GP6+ PCR‐based reverse‐blot assay to identify cervical intraepithelial neoplasias of grade 2 or worse (CIN2+). In total, 684 women were studied, of whom 377 (55%) were diagnosed with CIN2+ histologically. The specificity of HPV mRNA to predict histological CIN2+ was higher than that of HPV DNA (81.3% vs. 44.2%). The odds ratios (ORs) to predict histological CIN2+ in women with positive for type 16, 18, 31, and 45 E6 mRNA or by HPV DNA detection were 7.1 (95% confidence interval [CI] 3.9–13.1) and 2.5 (95%CI 1.9–3.5), respectively, compared to those with negative for E6 mRNA or HPV DNA. The OR to predict histological CIN2+ in women with a cytological grade
Salivary cortisol in a middle-aged community sample: results from 990 men and women of the KORA-F3 Augsburg study.

OBJECTIVE Analysis of salivary cortisol concentrations and derived indices is increasingly used in clinical and scientific medicine. However, comprehensive data on these parameters in the general population are scarce. The aim of this study was to evaluate the concentrations of salivary cortisol in a large middle-aged community sample and to identify major factors associated with altered hormone levels. DESIGN We conducted a cross-sectional study within the Cooperative Health Research in the Region of Augsburg (KORA)-F3 study. A total of 1484 participants aged 50-69 years (52% women) had agreed to provide four saliva samples during a regular weekday. METHODS We measured salivary cortisol concentrations at wake-up (F0), (1/2) h (F(1/2)), 8 h (F8), and 14 h (F14) after waking. We calculated cortisol awakening response (CAR), slope, and area under the curve (AUC(G)) of the circadian cortisol secretion. Sociodemographic and clinical characteristics were evaluated by interview and questionnaires, sampling conditions by protocol. In total, 1208 participants returned saliva samples, exclusion criteria left 990 subjects for final analyses. RESULTS Salivary cortisol levels were (means+/-s.d.) F0=13.7+/-7.6, F(1/2)=20.5+/-9.8, F8=5.4+/-3.3, and F14=2.0+/-1.8 nmol/l. Earlier sampling times were associated with higher CAR and smaller slope. Cortisol secretion was also influenced by gender and smoking habits. Higher perceived social support was associated with lower AUC(G) and smaller slope. CONCLUSIONS We provide data on salivary cortisol concentrations in a large middle-aged community sample. Gender, sampling time, smoking habits, and perceived social support appeared as determinants of cortisol secretion.
Investigation and Prediction of Human Interactome Based on Quantitative Features

Protein is one of the most significant components of all living creatures. All significant and essential biological structures and functions relies on proteins and their respective biological functions. However, proteins cannot perform their unique biological significance independently. They have to interact with each other to realize the complicated biological processes in all living creatures including human beings. In other words, proteins depend on interactions (protein-protein interactions) to realize their significant effects. Thus, the significance comparison and quantitative contribution of candidate PPI features must be determined urgently. According to previous studies, 258 physical and chemical characteristics of proteins have been reported and confirmed to definitively affect the interaction efficiency of the related proteins. Among such features, essential physiochemical features of proteins like stoichiometric balance, protein abundance, molecular weight and charge distribution have been validated to be quite significant and irreplaceable for protein-protein interactions (PPIs). Therefore, in this study, we, on one hand, presented a novel computational framework to identify the key factors affecting PPIs with Boruta feature selection (BFS), Monte Carlo feature selection (MCFS), incremental feature selection (IFS), and on the other hand, built a quantitative decision-rule system to evaluate the potential PPIs under real conditions with random forest (RF) and RIPPER algorithms, thereby supplying several new insights into the detailed biological mechanisms of complicated PPIs. The main datasets and codes can be downloaded at https://github.com/xypan1232/Mass-PPI.
AVALIAÇÃO QUANTITATIVA DE IMPACTOS AMBIENTAIS DA COLHEITA FLORESTAL EM DOIS MÓDULOS

Este trabalho teve como objetivo avaliar quantitativamente os impactos ambientais inerentes ao processo de colheita florestal em plantios de eucalipto, utilizando-se o metodo da matriz de interacao. As matrizes foram elaboradas em funcao dos modulos de colheita estudados (Motosserra + Guincho Arrastador e Motosserra + Forwarder) e preenchidas de acordo com a magnitude dos impactos, utilizando-se notas em uma escala de zero a cinco, adotando o sinal mais (+) para os impactos positivos e o sinal menos (-) para os negativos. De acordo com os resultados, o modulo que mostrou maiores problemas ambientais foi Motosserra + Guincho Arrastador. A atividade “corte semimecanizado” (derrubada) apresentou o maior saldo negativo medio de impacto no modulo Motosserra + Forwarder, sendo para Motosserra + Guincho Arrastador a atividade “guinchamento dos toretes” a mais impactante. No que se refere a distribuicao dos impactos, o meio biotico foi o mais expressivo, chegando a representar mais de 50% do saldo total de impactos nos dois modulos de colheita avaliados.
Translation of Culture-Specific Items in Self-Help Literature: A Study on Domestication and Foreignization Strategies

The last two decades have witnessed a boom in self-help materials in both global and local markets. This self-help trend, growing rapidly in our modern day, should be an area of interest for Translation Studies as an increasing number of self-help materials have been translated particularly from English every year. Self-help books involve a great deal of references to the material and social culture of the original country. One of the key issues in the translation of self-help books is the choice between foreignizing and domesticating these culture-specific items. This paper aims to discuss the procedures used for the translation of culture-specific items with regard to the particular function that these books assume in the target society. The analysis on the example of Outliers, a self-help book of sorts written by Malcolm Gladwell, has shown that the translator mostly adopted foreignizing strategies in translating the text into Turkish. The study also discusses whether these foreignizing strategies contribute to the fulfillment of target-text function, which is to provide quick-fix remedies to people struggling with modern-day challenges and demands.
An exception handling software architecture for developing fault-tolerant software

Fault-tolerant object-oriented software systems are inherently complex and have to cope with an increasing number of exceptional conditions in order to meet the system's dependability requirements. This work proposes a software architecture which integrates uniformly both concurrent and sequential exception handling. The exception handling architecture is independent of programming language or exception handling mechanism, and its use can minimize the complexity caused by the handling of abnormal behavior. Our architecture provides, during the architectural design stage, the context in which more detailed design decisions related to exception handling are made in later development stages. This work also presents a set of design patterns which describes the static and dynamic aspects of the components of our software architecture. The patterns allow a clear separation of concerns between the system's functionality and the exception handling facilities, applying the computational reflection technique.
Immunological Drivers in Graves' Disease: NK Cells as a Master Switcher

Graves' disease (GD) is a common autoimmune cause of hyperthyroidism, which is eventually related to the generation of IgG antibodies stimulating the thyrotropin receptor. Clinical manifestations of the disease reflect hyperstimulation of the gland, causing thyrocyte hyperplasia (goiter) and excessive thyroid hormone synthesis (hyperthyroidism). The above clinical manifestations are preceded by still partially unraveled pathogenic actions governed by the induction of aberrant phenotype/functions of immune cells. In this review article we investigated the potential contribution of natural killer (NK) cells, based on literature analysis, to discuss the bidirectional interplay with thyroid hormones (TH) in GD progression. We analyzed cellular and molecular NK-cell associated mechanisms potentially impacting on GD, in a view of identification of the main NK-cell subset with highest immunoregulatory role.
Scapular Muscle Recruitment Patterns: Trapezius Muscle Latency with and without Impingement Symptoms

Background Altered muscle activity in the scapular muscles is commonly believed to be a factor contributing to shoulder impingement syndrome. However, one important measure of the muscular coordination in the scapular muscles, the timing of the temporal recruitment pattern, is undetermined. Purpose To evaluate the timing of trapezius muscle activity in response to an unexpected arm movement in athletes with impingement and in normal control subjects. Study Design Prospective cohort study. Methods Muscle latency times were measured in all three parts of the trapezius muscle and in the middle deltoid muscle of 39 “overhand athletes” with shoulder impingement and compared with that of 30 overhand athletes with no impingement during a sudden downward falling movement of the arm. Results There were significant differences in the relative muscle latency times between the impingement and the control group subjects. Those with impingement showed a delay in muscle activation of the middle and lower trapezius muscle. Conclusion The results of this study indicate that overhand athletes with impingement symptoms show abnormal muscle recruitment timing in the trapezius muscle. The findings support the theory that impingement of the shoulder may be related to delayed onset of contraction in the middle and lower parts of the trapezius muscle.
Mapping Coeliac Toxic Motifs in the Prolamin Seed Storage Proteins of Barley, Rye, and Oats Using a Curated Sequence Database

Wheat gluten, and related prolamin proteins in rye, barley and oats cause the immune-mediated gluten intolerance syndrome, coeliac disease. Foods labelled as gluten-free which can be safely consumed by coeliac patients, must not contain gluten above a level of 20 mg/Kg. Current immunoassay methods for detection of gluten can give conflicting results and may underestimate levels of gluten in foods. Mass spectrometry methods have great potential as an orthogonal method, but require curated protein sequence databases to support method development. The GluPro database has been updated to include avenin-like sequences from bread wheat (n = 685; GluPro v1.1) and genes from the sequenced wheat genome (n = 699; GluPro v 1.2) and Triticum turgidum ssp durum (n = 210; GluPro v 2.1). Companion databases have been developed for prolamin sequences from barley (n = 64; GluPro v 3.0), rye (n = 41; GluPro v 4.0), and oats (n = 27; GluPro v 5.0) and combined to provide a complete cereal prolamin database, GluPro v 6.1 comprising 1,041 sequences. Analysis of the coeliac toxic motifs in the curated sequences showed that they were absent from the minor avenin-like proteins in bread and durum wheat and barley, unlike the related avenin proteins from oats. A comparison of prolamin proteins from the different cereal species also showed α- and γ-gliadins in bread and durum wheat, and the sulphur poor prolamins in all cereals had the highest density of coeliac toxic motifs. Analysis of ion-mobility mass spectrometry data for bread wheat (cvs Chinese Spring and Hereward) showed an increased number of identifications when using the GluPro v1.0, 1.1 and 1.2 databases compared to the limited number of verified sequences bread wheat sequences in reviewed UniProt. This family of databases will provide a basis for proteomic profiling of gluten proteins from all the gluten containing cereals and support identification of specific peptide markers for use in development of new methods for gluten quantitation based on coeliac toxic motifs found in all relevant cereal species.
A Novel Method of MOSFET Series Resistance Extraction Featuring Constant Mobility Criteria and Mobility Universality

A method of MOSFET series resistance extraction is established in this paper. The core of this method relies on the constant mobility criteria, while for different gate lengths, it preserves the shape of universal mobility curves in the high-vertical-field regime. Consequently, the series resistance of a MOSFET can be extracted in an analytical and self-consistent manner, achieved without the knowledge of the gate oxide thickness, channel length, channel doping, or channel stress. Reasonable values of extracted series resistance are demonstrated in a wide range of gate length. Technology computer-aided design simulation further corroborates the validity of the proposed method, particularly for devices with heavily doped source/drain extensions. The constant mobility criteria with respect to the bulk charge linearization coefficient are also verified.
An Adaptive Method for Gait Event Detection of Gait Rehabilitation Robots

Accurate gait event detection is necessary for control strategies of gait rehabilitation robots. However, due to personal diversity between individuals, it is a challenge for robots to detect a gait event at various stride frequencies. This paper proposes a novel method for gait event detection of a gait rehabilitation robot using a single inertial sensor mounted on the thigh. A self-adaptive threshold for detecting heel strike is obtained in real time via a linear regression model. Observable thresholds for toe off detection are constant at various stride frequencies. Experiments are conducted based on 20 healthy subjects and six hemiplegic patients wearing a gait rehabilitation robot and walking at various kinds of stride frequencies. The experimental results show that the proposed method can detect heel strike and toe off gait events within an average 2% gait cycle temporal errors and never miss two-gait event detection. Compared to the conventional thresholding method, this work presents a simple and robust application for gait event detection in healthy and hemiplegic subjects by one inertial sensor. The linear regression model can be applicable to different subjects walking at various stride frequencies.
Fitting a Flexible Model for Longitudinal Count Data Using the NLMIXED Procedure

Longitudinal count data arise when a subject's outcomes are measured repeatedly over time. Repeated measures count data have an inherent within-subject correlation that is commonly modeled with random effects in the standard Poisson regression. A Poisson regression model with random effects is easily fit in SAS® using existing options in the NLMIXED procedure. This model allows for over-dispersion via the nature of the repeated measures; however, departures from equi-dispersion can also exist due to the underlying count process mechanism. We present an extension of the cross-sectional Conway-MaxwellPoisson (COM-Poisson) regression model established by Sellers and Shmueli (2010) – a generalized regression model for count data in light of inherent data dispersion – to incorporate random effects for analysis of longitudinal count data. We detail how to fit the COM-Poisson longitudinal model via a userdefined log-likelihood function in PROC NLMIXED. We demonstrate the model flexibility of the COMPoisson longitudinal model via a real data example.