Miracle-dz/UniFAR-FTUs huggingface dataset:
The Prioritized-Layered Projection Algorithm for Visible Set Estimation

Prioritized-Layered Projection (PLP) is a technique for fast rendering of high depth complexity scenes. It works by estimating the visible polygons of a scene from a given viewpoint incrementally, one primitive at a time. It is not a conservative technique, instead PLP is suitable for the computation of partially correct images for use as part of time-critical rendering systems. From a very high level, PLP amounts to a modification of a simple view-frustum culling algorithm, however, it requires the computation of a special occupancy-based tessellation and the assignment to each cell of the tessellation a solidity value, which is used to compute a special ordering on how primitives get projected. The authors detail the PLP algorithm, its main components, and implementation. They also provide experimental evidence of its performance, including results on two types of spatial tessellation (using octree- and Delaunay-based tessellations), and several datasets. They also discuss several extensions of their technique.
De Clerambault’s Syndrome (Erotomania) As a Presenting Feature of Fronto-Temporal Dementia and Motor Neurone Disease (FTD-MND)

Motor neurone disease (MND) is characterized by the progressive degeneration of lower and upper motor neurones in the spinal cord, brainstem and motor cortex of the brain, leading to a variable pattern of motor dysfunction. Typical symptoms include muscle atrophy, limb weakness, bulbar palsy and respiratory failure. Fronto-Temporal Dementia (FTD) is a common neurodegenerative disorder associated with progressive atrophy of the frontal and temporal lobes of the brain, resulting in changes in personality and behaviour and/or speech and language dysfunction. Fifty per cent of patients with MND exhibit frontal executive deficits during the course of their illness, representing in most instances the co-occurrence of FTD. Previous
Muscle Deficits Persist After Unilateral Knee Replacement and Have Implications for Rehabilitation

Background: Knee joint arthritis causes pain, decreased range of motion, and mobility limitation. Knee replacement reduces pain effectively. However, people with knee replacement have decreases in muscle strength (“force-generating capacity”) of the involved leg and difficulties with walking and other physical activities. Objective and Design: The aim of this cross-sectional study was to determine the extent of deficits in knee extensor and flexor muscle torque and power (ability to perform work over time) and in the extensor muscle cross-sectional area (CSA) after knee joint replacement. In addition, the association of lower-leg muscle deficits with mobility limitations was investigated. Methods: Participants were 29 women and 19 men who were 55 to 75 years old and had undergone unilateral knee replacement surgery an average of 10 months earlier. The maximal torque and power of the knee extensor and flexor muscles were measured with an isokinetic dynamometer. The knee extensor muscle CSA was measured with computed tomography. The symmetry deficit between the knee that underwent replacement surgery (“operated knee”) and the knee that did not undergo replacement surgery (“nonoperated knee”) was calculated. Maximal walking speed and stair-ascending and stair-descending times were assessed. Results: The mean deficits in knee extensor and flexor muscle torque and power were between 13% and 27%, and the mean deficit in the extensor muscle CSA was 14%. A larger deficit in knee extension power predicted slower stair-ascending and stair-descending times. This relationship remained unchanged when the power of the nonoperated side and the potential confounding factors were taken into account. Limitations: The study sample consisted of people who were relatively healthy and mobile. Some participants had osteoarthritis in the nonoperated knee. Conclusions: Deficits in muscle torque and power and in the extensor muscle CSA were present 10 months after knee replacement, potentially causing limitations in negotiating stairs. To prevent mobility limitations and disability, deficits in lower-limb power should be considered during rehabilitation after knee replacement.
Effect of Crystallization Process at Cryogenic Conditions on the Functional Properties of the SUPERSTON Alloy Used in Production the Ship’s Propellers

The purpose of this paper is to show results of laser treatment at cryogenic conditions of the SUPERSTON alloy used for ship’s propellers. That modification process ought to bring beneficial changes of microstructure and residual stresses in the surface layer. During the laser remelting at cryogenic conditions the microstructure changes significantly. This is related to synergistic effects of the solidification rate, phase transformations in the solid state and laser treatment parameters. That crystallization process had influence on functional properties such as corrosion and cavitation resistance of the SUPERSTON alloy which were tested during researches.
Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics – Insights from a 3D Model of the Human Atria

Aims Atrial stunning, a loss of atrial mechanical contraction, can occur following a successful cardioversion. It is hypothesized that persistent atrial fibrillation-induced electrical remodeling (AFER) on atrial electrophysiology may be responsible for such impaired atrial mechanics. This simulation study aimed to investigate the effects of AFER on atrial electro-mechanics. Methods and Results A 3D electromechanical model of the human atria was developed to investigate the effects of AFER on atrial electro-mechanics. Simulations were carried out in 3 conditions for 4 states: (i) the control condition, representing the normal tissue (state 1) and the tissue 2–3 months after cardioversion (state 2) when the atrial tissue recovers its electrophysiological properties after completion of reverse electrophysiological remodelling; (ii) AFER-SR condition for AF-remodeled tissue with normal sinus rhythm (SR) (state 3); and (iii) AFER-AF condition for AF-remodeled tissue with re-entrant excitation waves (state 4). Our results indicate that at the cellular level, AFER (states 3 & 4) abbreviated action potentials and reduced the Ca2+ content in the sarcoplasmic reticulum, resulting in a reduced amplitude of the intracellular Ca2+ transient leading to decreased cell active force and cell shortening as compared to the control condition (states 1 & 2). Consequently at the whole organ level, atrial contraction in AFER-SR condition (state 3) was dramatically reduced. In the AFER-AF condition (state 4) atrial contraction was almost abolished. Conclusions This study provides novel insights into understanding atrial electro-mechanics illustrating that AFER impairs atrial contraction due to reduced intracellular Ca2+ transients.
Blind noise suppression for Non-Audible Murmur recognition with stereo signal processing

In this paper, we propose a blind noise suppression method for Non-Audible Murmur (NAM) recognition. NAM is a very soft whispered voice detected with NAM microphone, which is one of the body-conductive microphones. Due to its recording mechanism, the detected signal suffers from noise caused by speaker's movements. In the proposed method using a stereo signal detected with two NAM microphones, the noise is estimated with blind source separation, and then, spectral subtraction is performed in each channel to reduce the noise. Moreover, channel selection is performed frame by frame to generate less distorted monaural NAM signal. Experimental results show that 1) word accuracy in large vocabulary continuous NAM recognition is degraded from 69.2% to 53.6% by the noise and 2) it is significantly recovered to 63.3% in a simulated situation and 58.6% in a real situation with the proposed method.
Rethinking Measurement of Pay Disparity and Its Relation to Firm Performance

I develop measures of firm-level pay disparity and examine their relation to firm performance. Using comprehensive compensation data for a large sample of firms, I find no statistically significant relation between the ratio of CEO-to-mean employee compensation and performance. I next create empirical models that allow me to separate the components of CEO and employee compensation explained by economic factors from those that are not, and use these models to estimate explained and unexplained pay disparity. After validating my estimate of unexplained pay disparity as a proxy for pay fairness, I find robust evidence of a negative (positive) relation between unexplained (explained) pay disparity and future firm performance. JEL Classifications: G32; G35; J31; M12; M14; M52.
Une couche indépendante des FTL pour améliorer les performances des écritures aléatoires sur mémoires flash

Les memoires ﬂash deviennent une alternative competitive aux disques durs comme support de stockage non-volatile pour les systemes de gestion de base de donnees. Cependant, des adaptations speciﬁques sont necessaires pour exploiter au mieux cette nouvelle categorie de stockage. Pour cela, la definition des modeles d’acces preconises est un probleme complexe car les memoires ﬂash sont tres heterogenes et difficiles a caracteriser, a cause de la Flash Translation Layer – ou FTL – qui leur est integree. Dans cet article nous identifions une correlation forte entre les performances des ecritures et leur proximite spatiale pour un sous-ensemble des memoires ﬂash ; puis definissons une distance pour quantifier cet effet. A partir de cette propriete, nous proposons un algorithme de placement des donnees permettant d’ameliorer les performances en ecriture aleatoire en contrepartie d’une diminution de la capacite de la memoire. L’efficacite de cette technique est validee par une formalisation avec un modele mathematique et des resultats experimentaux. Avec cette optimisation, les ecritures aleatoires deviennent potentiellement aussi efficaces que les ecritures sequentielles, allant jusqu’a ameliorer leurs performances de deux ordres de grandeur.
Indoor and outdoor localization for fast mobile robots

This paper describes a novel, laser-based approach for tracking the pose of a high-speed mobile robot. The algorithm is outstanding in terms of accuracy and computational time, being 33 times faster than real time. The efficiency is achieved by a closed form solution for the matching of two lasers scans, the use of natural landmarks and fast linear filters. The implemented algorithm is evaluated with the high-speed robot Kurt3D (4 m/s), and compared to standard scan matching methods in indoor and outdoor environments.
Expression patterns of cardiac aging in Drosophila

Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age‐associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well‐suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks, benefit from many tools to easily manipulate their genome, and their heart has significant genetic and phenotypic similarities to the human heart. Here, we performed a cardiac‐specific gene expression study on aging Drosophila and carried out a comparative meta‐analysis with published rodent data. Pathway level transcriptome comparisons suggest that age‐related, extra‐cellular matrix remodeling and alterations in mitochondrial metabolism, protein handling, and contractile functions are conserved between Drosophila and rodent hearts. However, expression of only a few individual genes similarly changed over time between and even within species. We also examined gene expression in single fly hearts and found significant variability as has been reported in rodents. We propose that individuals may arrive at similar cardiac aging phenotypes via dissimilar transcriptional changes, including those in transcription factors and micro‐RNAs. Finally, our data suggest the transcription factor Odd‐skipped, which is essential for normal heart development, is also a crucial regulator of cardiac aging.
A Coarse To Fine Multiscale Approach For Linear Least Squares Optical Flow Estimation

Tensor-based approaches for optical flow have been often criticized because of their limitations in handling large motions. This paper shows how to adapt them in a multiscale coarse-to-fine strategy. We show how the same ideas used in the variational framework can be adapted by working with both a multiscale image sequence as well as a multiscale, motion compensated tensor field. Several experiments are presented in order to compare it to some recent well known multiscale techniques. We demonstrate how this approach offers a good compromise between precision and computational efficiency.
The Interaction of Temperature and Bending Load on Structural Performance of Chinese Larch Wood

Wood is being used extensively in timber construction in China. In fire-resistant design for timber construction, the main goal is to ensure that enough structural integrity is maintained during a fire to prevent structure collapse. It is important to understand its structural performance when exposed to elevated temperatures and loaded by stress levels. To study the interaction effect of Chinese larch wood, a total of 72 small clear wood samples were observed under constant stress levels when the wood temperature was elevated. The results indicated that Chinese larch wood was more susceptible to the coupling effect of temperature and stress. The interaction promoted a temporary stable flexural structure to collapse during a short exposure time.
Membrane Potentials, Synaptic Responses, Neuronal Circuitry, Neuromodulation and Muscle Histology Using the Crayfish: Student Laboratory Exercises

The purpose of this report is to help develop an understanding of the effects caused by ion gradients across a biological membrane. Two aspects that influence a cell's membrane potential and which we address in these experiments are: (1) Ion concentration of K+ on the outside of the membrane, and (2) the permeability of the membrane to specific ions. The crayfish abdominal extensor muscles are in groupings with some being tonic (slow) and others phasic (fast) in their biochemical and physiological phenotypes, as well as in their structure; the motor neurons that innervate these muscles are correspondingly different in functional characteristics. We use these muscles as well as the superficial, tonic abdominal flexor muscle to demonstrate properties in synaptic transmission. In addition, we introduce a sensory-CNS-motor neuron-muscle circuit to demonstrate the effect of cuticular sensory stimulation as well as the influence of neuromodulators on certain aspects of the circuit. With the techniques obtained in this exercise, one can begin to answer many questions remaining in other experimental preparations as well as in physiological applications related to medicine and health. We have demonstrated the usefulness of model invertebrate preparations to address fundamental questions pertinent to all animals.
Situated cognition and learning environments: implications for teachers on- and offline in the new digital media age

John Seely Brown suggested that learning environments should be spaces in which all work is public, is subject to iterative critique by instructors and peers, and in which social interaction is primary. In such spaces, students and teachers engage in a situated cognition approach to teaching and learning where “cognitive accomplishments rely in part on structures and processes outside the individual”. Here we describe a qualitative analysis of a socially situated learning setting that aimed to develop children who can design, analyze, critique, and transform media, subjecting existing social media, their designs, and their peers’ designs to public and iterative critique. In this setting, adult mentors supported children’s self-expression, self-reflection, and skillbuilding through authentic, socially situated reading, writing, and discussion, and media production. Creating and leveraging such spaces is essential for preparing all children for successful experiences in the new knowledge economy in formal and informal educational settings.
Single-molecule studies of DNA transcription using atomic force microscopy

Atomic force microscopy (AFM) can detect single biomacromolecules with a high signal-to-noise ratio on atomically flat biocompatible support surfaces, such as mica. Contrast arises from the innate forces and therefore AFM does not require imaging contrast agents, leading to sample preparation that is relatively straightforward. The ability of AFM to operate in hydrated environments, including humid air and aqueous buffers, allows structure and function of biological and biomolecular systems to be retained. These traits of the AFM are ensuring that it is being increasingly used to study deoxyribonucleic acid (DNA) structure and DNA–protein interactions down to the secondary structure level. This report focuses in particular on reviewing the applications of AFM to the study of DNA transcription in reductionist single-molecule bottom-up approaches. The technique has allowed new insights into the interactions between ribonucleic acid (RNA) polymerase to be gained and enabled quantification of some aspects of the transcription process, such as promoter location, DNA wrapping and elongation. More recently, the trend is towards studying the interactions of more than one enzyme operating on a single DNA template. These methods begin to reveal the mechanics of gene expression at the single-molecule level and will enable us to gain greater understanding of how the genome is transcribed and translated into the proteome.
Site-specific O-Glycosylation Analysis of Human Blood Plasma Proteins*

Site-specific glycosylation analysis is key to investigate structure-function relationships of glycoproteins, e.g. in the context of antigenicity and disease progression. The analysis, though, is quite challenging and time consuming, in particular for O-glycosylated proteins. In consequence, despite their clinical and biopharmaceutical importance, many human blood plasma glycoproteins have not been characterized comprehensively with respect to their O-glycosylation. Here, we report on the site-specific O-glycosylation analysis of human blood plasma glycoproteins. To this end pooled human blood plasma of healthy donors was proteolytically digested using a broad-specific enzyme (Proteinase K), followed by a precipitation step, as well as a glycopeptide enrichment and fractionation step via hydrophilic interaction liquid chromatography, the latter being optimized for intact O-glycopeptides carrying short mucin-type core-1 and -2 O-glycans, which represent the vast majority of O-glycans on human blood plasma proteins. Enriched O-glycopeptide fractions were subjected to mass spectrometric analysis using reversed-phase liquid chromatography coupled online to an ion trap mass spectrometer operated in positive-ion mode. Peptide identity and glycan composition were derived from low-energy collision-induced dissociation fragment spectra acquired in multistage mode. To pinpoint the O-glycosylation sites glycopeptides were fragmented using electron transfer dissociation. Spectra were annotated by database searches as well as manually. Overall, 31 O-glycosylation sites and regions belonging to 22 proteins were identified, the majority being acute-phase proteins. Strikingly, also 11 novel O-glycosylation sites and regions were identified. In total 23 O-glycosylation sites could be pinpointed. Interestingly, the use of Proteinase K proved to be particularly beneficial in this context. The identified O-glycan compositions most probably correspond to mono- and disialylated core-1 mucin-type O-glycans (T-antigen). The developed workflow allows the identification and characterization of the major population of the human blood plasma O-glycoproteome and our results provide new insights, which can help to unravel structure-function relationships. The data were deposited to ProteomeXchange PXD003270.
Multicellularity enriches the entrainment of Arabidopsis circadian clock

Novel methods reveal how single-cell behavior translates to organism level in phase response properties of plant circadian clocks. The phase response curve (PRC) of the circadian clock provides one of the most significant indices for anticipating entrainment of outer cycles, despite the difficulty of making precise PRC determinations in experiments. We characterized the PRC of the Arabidopsis thaliana circadian clock on the basis of its phase-locking property to variable periodic pulse perturbations. Experiments revealed that the PRC changed remarkably from continuous to discontinuous fashion, depending on the oscillation amplitude. Our hypothesis of amplitude-dependent adaptability to outer cycles was successfully clarified by elucidation of this transition of PRC as a change in the collective response of the circadian oscillator network. These findings provide an essential criterion against which to evaluate the precision of PRC measurement and an advanced understanding of the adaptability of plant circadian systems to environmental conditions.
Cache updates in a peer-to-peer network of mobile agents

In open multi-agent systems, agents need resources provided by other agents but they are not aware of which agents provide particular resources. We consider a peer-to-peer approach, in which each agent maintains a local cache with information about k resources, that is for each of the k resources, an agent that provides it. However, when an agent or a resource moves, cache entries become obsolete. We propose a suite of cache update policies that combine pull-based invalidation that is initiated by the agent that maintains the cache with push-based invalidation that is initiated by the agent that moves. We study and compare variations of oblivious flooding-based push/pull along with an informed push approach where each agent maintains a list of the agents that have it cached. Our experimental results indicate that a novel variation of flooding for push where a moving agent propagates its new location to agents in its old neighborhood achieves good cache consistency with a small message overhead. The proposed policies are suitable for any peer-to-peer system where peers cache information about other peers and this information becomes obsolete.
Meeting report: Vitiligo Global Issues Consensus Conference Workshop “Outcome measurement instruments” and Vitiligo International Symposium, Rome, Nov 30–Dec 3rd

The international vitiligo community had last December its first "vitiligo only" research meeting in the Eternal City. Vitiligo is a well-recognized but poorly addressed public health concern worldwide. The Vitiligo International Symposium (VIS) is a strong signal for the medical world of the coming of age of vitiligo as a major research field. Because of the gathering of the majority of world experts, the meeting was preceded by a clinical research methodology workshop held at the San Gallicano Institute. This report gives a combined account of the two parts. This article is protected by copyright. All rights reserved