Miracle-dz/UniFAR-FTUs huggingface dataset:
Heterogeneous Wireless Networks for Smart Grid Distribution Systems: Advantages and Limitations

Supporting a conventional power grid with advanced communication capabilities is a cornerstone to transferring it to a smart grid. A reliable communication infrastructure with a high throughput can lay the foundation towards the ultimate objective of a fully automated power grid with self-healing capabilities. In order to realize this objective, the communication infrastructure of a power distribution network needs to be extended to cover all substations including medium/low voltage ones. This shall enable information exchange among substations for a variety of system automation purposes with a low latency that suits time critical applications. This paper proposes the integration of two heterogeneous wireless technologies (such as WiFi and cellular 3G/4G) to provide reliable and fast communication among primary and secondary distribution substations. This integration allows the transmission of different data packets (not packet replicas) over two radio interfaces, making these interfaces act like a one data pipe. Thus, the paper investigates the applicability and effectiveness of employing heterogeneous wireless networks (HWNs) in achieving the desired reliability and timeliness requirements of future smart grids. We study the performance of HWNs in a realistic scenario under different data transfer loads and packet loss ratios. Our findings reveal that HWNs can be a viable data transfer option for smart grids.
Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis

Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS. Here we show that during early and late disseminated infection, B. burgdorferi infects the meninges of intradermally infected mice, and is associated with concurrent increases in meningeal T cells. We found that the dura mater was consistently culture positive for spirochetes in transcardially perfused mice, independent of the strain of B. burgdorferi used. Within the dura mater, spirochetes were preferentially located in vascular regions, but were also present in perivascular, and extravascular regions, as late as 75 days post-infection. At the same end-point, we observed significant increases in the number of CD3+ T cells within the pia and dura mater, as compared to controls. Flow cytometric analysis of leukocytes isolated from the dura mater revealed that CD3+ cell populations were comprised of both CD4 and CD8 T cells. Overall, our data demonstrate that similarly to infection in peripheral tissues, spirochetes adhere to the dura mater during disseminated infection, and are associated with increases in the number of meningeal T cells. Collectively, our results demonstrate that there are aspects of B. burgdorferi meningeal infection that can be modelled in laboratory mice, suggesting that mice may be useful for elucidating mechanisms of meningeal pathogenesis by B. burgdorferi.
Quantitative Analysis of Nutrient Elements in Soil Using Single and Double-Pulse Laser-Induced Breakdown Spectroscopy

Rapid detection of soil nutrient elements is beneficial to the evaluation of crop yield, and it’s of great significance in agricultural production. The aim of this work was to compare the detection ability of single-pulse (SP) and collinear double-pulse (DP) laser-induced breakdown spectroscopy (LIBS) for soil nutrient elements and obtain an accurate and reliable method for rapid detection of soil nutrient elements. 63 soil samples were collected for SP and collinear DP signal acquisition, respectively. Macro-nutrients (K, Ca, Mg) and micro-nutrients (Fe, Mn, Na) were analyzed. Three main aspects of all elements were investigated, including spectral intensity, signal stability, and detection sensitivity. Signal-to-noise ratio (SNR) and relative standard deviation (RSD) of elemental spectra were applied to evaluate the stability of SP and collinear DP signals. In terms of detection sensitivity, the performance of chemometrics models (univariate and multivariate analysis models) and the limit of detection (LOD) of elements were analyzed, and the results indicated that the DP-LIBS technique coupled with PLSR could be an accurate and reliable method in the quantitative determination of soil nutrient elements.
Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages

This work explores the feasibility of combining anatomical MRI data across two public repositories namely, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Progressive Parkinson’s Markers Initiative (PPMI). We compared cortical thickness and subcortical volumes in cognitively normal older adults between datasets with distinct imaging parameters to assess if they would provide equivalent information. Three distinct datasets were identified. Major differences in data were scanner manufacturer and the use of magnetization inversion to enhance tissue contrast. Equivalent datasets, i.e., those providing similar volumetric measurements in cognitively normal controls, were identified in ADNI and PPMI. These were datasets obtained on the Siemens scanner with TI = 900 ms. Our secondary goal was to assess the agreement between subcortical volumes that are obtained with different software packages. Three subcortical measurement applications (FSL, FreeSurfer, and a recent multi-atlas approach) were compared. Our results show significant agreement in the measurements of caudate, putamen, pallidum, and hippocampus across the packages and poor agreement between measurements of accumbens and amygdala. This is likely due to their smaller size and lack of gray matter-white matter tissue contrast for accurate segmentation. This work provides a segue to combine imaging data from ADNI and PPMI to increase statistical power as well as to interrogate common mechanisms in disparate pathologies such as Alzheimer’s and Parkinson’s diseases. It lays the foundation for comparison of anatomical data acquired with disparate imaging parameters and analyzed with disparate software tools. Furthermore, our work partly explains the variability in the results of studies using different software packages.
Predicting phototoxicity of alkylated PAHs, mixtures of PAHs, and water accommodated fractions (WAF) of neat and weathered petroleum with the phototoxic target lipid model

The toxicity of petroleum can increase considerably after exposure to solar radiation, during which certain components in the mixture, including polycyclic aromatic hydrocarbons (PAHs), absorb light in ultraviolet and visible portions of the solar radiation spectrum. A phototoxic target lipid model (PTLM), previously developed to predict the phototoxicity of single PAHs, is validated for 4 species (Americamysis bahia, Rhepoxynius abronius, Daphnia magna, and Pimephales promelas) exposed to 12 compounds that are components of petroleum, including alkylated PAHs and dibenzothiophene. The PTLM is also used to predict the phototoxicity of binary and ternary mixtures of 3 PAHs, pyrene, anthracene, and fluoranthene, to A. bahia and Menidia beryllina. Finally, it is used to predict the toxicity of water accommodated fractions of neat and naturally weathered Macondo crude oil samples from the Deepwater Horizon oil spill sites. The Gulf of Mexico species, including A. bahia, M. beryllina, Cyprinodon variegatus, and Fundulus grandis were exposed to the oil samples under natural and simulated solar radiation. The results support the applicability of the PTLM for predicting the phototoxicity of petroleum. Environ Toxicol Chem 2018;37:2165–2174. © 2018 SETAC.
Summary of the NACI Statement on Seasonal Influenza Vaccine for 2017-2018.

Background Influenza is a respiratory infection caused primarily by influenza A and B viruses. Vaccination is the most effective way to prevent influenza and its complications. The National Advisory Committee on Immunization (NACI) provides recommendations regarding seasonal influenza vaccines annually to the Public Health Agency of Canada (PHAC). Objective To summarize the NACI recommendations regarding the use of seasonal influenza vaccines for the 2017-2018 influenza season. Methods Annual influenza vaccine recommendations are developed by NACI's Influenza Working Group for consideration and approval by NACI, based on NACI's evidence-based process for developing recommendations. The recommendations include a consideration of the burden of influenza illness and the target populations for vaccination; efficacy and effectiveness, immunogenicity and safety of influenza vaccines; vaccine schedules; and other aspects of influenza immunization. These recommendations are published annually on the Agency's website in the NACI Advisory Committee Statement: Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine (the Statement). Results The annual statement has been updated for the 2017-2018 influenza season to incorporate recommendations for the use of live attenuated influenza vaccine (LAIV) that were contained in two addenda published after the 2016-2017 statement. These recommendations were 1) that egg-allergic individuals may be vaccinated against influenza using the low ovalbumin-containing LAIV licensed for use in Canada and 2) to continue to recommend the use of LAIV in children and adolescents 2-17 years of age, but to remove the preferential recommendation for its use. Conclusion NACI continues to recommend annual influenza vaccination for all individuals aged six months and older, with particular focus on people at high risk of influenza-related complications or hospitalization, people capable of transmitting influenza to those at high risk, and others as indicated.
The use of technology to improve health care to Saskatchewan's First Nations communities.

Background Saskatchewan is a province of over one million people and over 13% are Indigenous peoples, many of whom live on reserve lands. Despite continued efforts, access to health care remains a significant challenge for these Indigenous people, especially those in the North. Objective To address this challenge, Saskatchewan's health care providers have been incorporating the use of technology for various health services. This paper describes various ways technology has been used in First Nations communities in Saskatchewan. Methods Several pilot projects between First Nations leaders and health care providers, in the communities as well as in the urban setting, have taken place over the past 10 years. Information on these pilots was supplemented with literature reviews and consultations with colleagues at the Northern Inter-Tribal Health Authority, the First Nations and Inuit Health Branch (FNIHB), Health Canada and lead physicians for services to the North. Results Numerous technologies have shown promise in aiding the timely delivery of high quality health care. Remote Presence Robotic Technology (RPRT) is a form of telemedicine that creates the sense that a clinician is at the patient's side; enabling clinical services to be provided remotely and in real time. Increasing access to internet services and providing computer tablets to community health nurses have improved patients' access to clinical care and to vital health care information. Robotic ultrasonography has been used to provide onsite care for pre-natal patients. The provision of cell phones to HIV-positive patients has improved compliance with anti-retroviral therapy and has resulted in better clinical outcomes. The Xpert MTB/RIF (Mycobacerium tuberculosis complex / resistance to rifampicin) is an automated device that, through analysis of raw sputum samples, can identify the presence of M. tuberculosis with greater speed, sensitivity and specificity than the conventional acid-fast bacilli (AFB) smear. Similarly, telemedicine remote communications equipment is being used for patient care across communities. Panorama is a comprehensive, integrated public health information system designed for public health professionals and is currently being introduced in 21 communities in Saskatchewan. Conclusion Not only do these innovative technologies appear to improve access and enhance the quality of timely care in remote communities but they also bring comfort to patients, prevent unnecessary transportation and minimize time away from work and family. Although these technologies are not a panacea for some of the determinants of health that can affect the incidence and severity of infectious diseases in First Nations, they do appear to address some of the geographic challenges faced in providing health services in remote communities.
Quantitative Live-cell Reporter Assay for Noncanonical Wnt Activity

Noncanonical Wnt signaling functions independently of the β-catenin pathway to control diverse developmental processes, and dysfunction of the pathway contributes to a number of human pathological conditions, including birth defects and metastatic cancer. Progress in the field, however, has been hampered by the scarcity of functional assays for measuring noncanonical Wnt signaling activity. We recently described the Wnt5a-Ror-Kif26b (WRK) reporter assay, which directly monitors a post-transcriptional regulatory event in noncanonical Wnt signaling. In this protocol, we describe the generation of the stable GFP-Kif26b reporter cell line and a quantitative reporter assay for detecting and measuring Wnt5a signaling activities in live cells via flow cytometry.
Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats

In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostasis model assessment–insulin resistance scores, lipid peroxidation concentration, glucose-6-phosphatase activity, and all concentrations of anti-inflammatory studied in alloxan-induced diabetic rats were significantly (P < .05) reduced with the administration of polyphenolic-rich extract of Syzygium cumini leaves. Also there was significant (P < .05) increase in glycogen and insulin concentrations, pancreatic β-cell scores, antioxidant enzymes and hexokinase activities, as well as glucose transporter levels in diabetic animals administered with polyphenolic-rich extract of S cumini leaves. The results indicate that S cumini leaves possess anti-hyperglycemic and anti-inflammatory activities.
CryptRndTest: An R Package for Testing the Cryptographic Randomness

In this article, we introduce the R package CryptRndTest that performs eight statistical randomness tests on cryptographic random number sequences. The purpose of the package is to provide software implementing recently proposed cryptographic randomness tests utilizing goodness-of-fit tests superior to the usual chi-square test in terms of statistical performance. Most of the tests included in package CryptRndTest are not available in other software packages such as the R package RDieHarder or the C library TestU01. Chi-square, Anderson-Darling, Kolmogorov-Smirnov, and Jarque-Bera goodness-of-fit procedures are provided along with cryptographic randomness tests. CryptRndTest utilizes multiple precision floating numbers for sequences longer than 64-bit based on the package Rmpfr. By this way, included tests are applied precisely for higher bit-lengths. In addition CryptRndTest provides a user friendly interface to these cryptographic randomness tests. As an illustrative application, CryptRndTest is used to test available random number generators in R.
Self‐Rolling of Oxide Nanomembranes and Resonance Coupling in Tubular Optical Microcavity

Nanomembrane self‐rolling offers the manufacture flexibility of 3D architectures for various applications in photonics, robotics, electronics, etc. Rolled‐up oxide microtubes fabricated by both wet chemical etching and dry‐releasing methods enable a broad range tuning of diameters (from 1 to 15 μm) and therefore same to their optical whispering gallery modes (WGMs). Their thin walls (several tens of nanometers) of such tubular optical microcavities provide strongly on‐resonance coupling of attached dye emitters to optical modes, which leads to a cavity enhancement for Raman scattering without importing noble metal. Rolled‐up thin‐walled oxide tubular microcavity delivers a new optical component for light coupling and may imply interesting applications in the interaction between light and matter.
Nrf2‐dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

This study investigates the possible mechanism(s) underlying glutathione (GSH) deficiency in the mouse spinal cord during the course of myelin oligodendrocyte glycoprotein35–55 peptide‐induced experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of multiple sclerosis. Using the classical enzymatic recycling method and a newly developed immunodot assay, we first demonstrated that total GSH levels (i.e. free GSH plus all its adducts) are reduced in EAE, suggesting an impaired synthesis. The decline in the levels of this essential antioxidant tripeptide in EAE coincides temporally and in magnitude with a reduction in the amount of γ‐glutamylcysteine ligase, the rate‐limiting enzyme in GSH synthesis. Other enzymes involved in GSH biosynthesis, whose genes also contain antioxidant‐response elements, including glutathione synthetase, cystine/glutamate antiporter, and γ‐glutamyl transpeptidase (γ‐GT) are diminished in EAE as well. Low levels of γ‐glutamylcysteine ligase, glutathione synthetase, and γ‐GT are the consequence of reduced mRNA expression, which correlates with diminished expression of the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) in both the cytosol and nucleus. Interestingly, the low Nrf2 expression does not seem to be caused by increased degradation via Kelch‐like ECH‐associated protein 1‐dependent or Kelch‐like ECH‐associated protein 1‐independent mechanisms (such as glycogen synthetase kinase‐3β activation), or by reduced levels of Nrf2 mRNA. This suggests that translation of this important transcription factor and/or other still unidentified post‐translational processes are altered in EAE. These novel findings are central toward understanding how critical antioxidant and protective responses are lost in inflammatory demyelinating disorders.
Deciding on large scale investments

ABSTRACT This study analyses the importance of investment factors across investment sizes and the frequency of large investment decisions within the firms. We use data from 1442 investment decisions made by 226 Brazilian firms between 1997 and 2010. The results indicate that the influence of investment factors is different for investments of different sizes. The results also indicate that the increase in the frequency of large-scale investment decisions made by the firm influences especially the role of cash flow, diminishing its importance as an investment factor. This result allows one to argue that, probably, firms more experienced in large-scale decisions could be bolder in their decision-making process, relying less on the accumulation of funds through cash flow.
Ligand binding and activation properties of the purified bacterial cyclic nucleotide–gated channel SthK

Cyclic nucleotide–modulated ion channels play several essential physiological roles. They are involved in signal transduction in photoreceptors and olfactory sensory neurons as well as pacemaking activity in the heart and brain. Investigations of the molecular mechanism of their actions, including structural and electrophysiological characterization, are restricted by the availability of stable, purified protein obtained from accessible systems. Here, we establish that SthK, a cyclic nucleotide–gated (CNG) channel from Spirochaeta thermophila, is an excellent model for investigating the gating of eukaryotic CNG channels at the molecular level. The channel has high sequence similarity with its eukaryotic counterparts and was previously reported to be activated by cyclic nucleotides in patch-clamp experiments with Xenopus laevis oocytes. We optimized protein expression and purification to obtain large quantities of pure, homogeneous, and active recombinant SthK protein from Escherichia coli. A negative-stain electron microscopy (EM) single-particle analysis indicated that this channel is a promising candidate for structural studies with cryo-EM. Using radioactivity and fluorescence flux assays, as well as single-channel recordings in lipid bilayers, we show that the protein is partially activated by micromolar concentrations of cyclic adenosine monophosphate (cAMP) and that channel activity is increased by depolarization. Unlike previous studies, we find that cyclic guanosine monophosphate (cGMP) is also able to activate SthK, but with much lower efficiency than cAMP. The distinct sensitivities to different ligands resemble eukaryotic CNG and hyperpolarization-activated and cyclic nucleotide–modulated channels. Using a fluorescence binding assay, we show that cGMP and cAMP bind to SthK with similar apparent affinities, suggesting that the large difference in channel activation by cAMP or cGMP is caused by the efficacy with which each ligand promotes the conformational changes toward the open state. We conclude that the functional characteristics of SthK reported here will permit future studies to analyze ligand gating and discrimination in CNG channels.
The Timeliness Of The Australian Annual-Report - 1972-1977

Dyer and McHugh [1975] report the results of an investigation into the timeliness of the Australian annual report. They defined and studied, over the period 1965-71 inclusive, three principal lags: preliminary, auditor's signature, and total lag. Each of these lags was shown to be stable over the period of their study, with the exception that the 1971 total lag appeared to have increased from 102 to 118 days over the seven-year period. This note reports the results of a replication of the Dyer and McHugh (hereafter DM) study over the period since their data terminated to the most recent financial year for which complete data are available, that is, the six-year period 1972-77 inclusive. The primary purpose in doing this is to assess the effect on time lags (if any) of a new listing requirement adopted by the Australian Associated Stock Exchanges in 1972. That requirement stated that "The interval between the close of the financial year of the company and the issue of accounts relating to it shall not exceed four months" [sec. 3.C. (1)]. A secondary purpose of this note is to point out a methodological limitation in the DM study.