Miracle-dz/UniFAR-FTUs huggingface dataset:
Trajectory Pattern Mining in Practice - Algorithms for Mining Flock Patterns from Trajectories

In this paper, we implement recent theoretical progress of depth-first algorithms for mining flock patterns (Arimura et al., 2013) based on depth-first frequent itemset mining approach, such as Eclat (Zaki, 2000) or LCM (Uno et al., 2004). Flock patterns are a class of spatio-temporal patterns that represent a groups of moving objects close each other in a given time segment (Gudmundsson and van Kreveld, Proc. ACM GIS’06; Benkert, Gudmundsson, Hubner, Wolle, Computational Geometry, 41:11, 2008). We implemented two extensions of a basic algorithm, one for a class of closed patterns, called rightward length-maximal flock patterns, and the other with a speed-up technique using geometric indexes. To evalute these extensions, we ran experiments on synthesis datasets. The experiments demonstrate that the modified algorithms with the above extensions are several order of magnitude faster than the original algorithm in most parameter settings.
CO2 Flow Boiling in Small Diameter Smooth and Micro-Fin Tubes

Experiments on flow pattern and flow boiling heat transfer of CO2 and CO2-oil mixtures in horizontal small diameter smooth and micro-fin tubes were carried out. The test smooth tube is a stainless steel tube, 2.0mm in inner diameter and 1m in length. And the test micro-fin tube is an inner grooved copper tube, 1.95mm in mean inner diameter and 1 m in length. Experiments were conducted at mass velocities from 380 to 1500 kg/(ms), a saturation temperature of 10°C, heat fluxes from 10 to 43.3 kW/m. The flow patterns in both the tubes were observed and the results were compared with the flow pattern map proposed by Cheng et al. for smooth tubes. And the measured local heat transfer coefficients for the smooth and micro-fin tubes were compared with those calculated from the prediction correlations proposed by Cheng et al. for smooth tubes. As the results, the flow patterns in both the tubes correspond well with the flow pattern map. On flow boiling heat transfer of pure CO2, the prediction model agrees well with the experimental data of the smooth tube, and the measured local heat transfer coefficients of the micro-fin tube are about 31% higher than those of the smooth tube. For CO2-oil mixtures, the measured local heat transfer coefficients of both the smooth and micro-fin tubes are much lower than those of pure CO2. The dryout inception qualities of the micro-fin tube increase with the increase in mass velocities, while those of the smooth tube decrease with the increase in mass velocities. The dryout inception qualities of the micro-fin tube are much higher than those of the smooth tube.
Composite Materials As an Alternative to Replace Steel Members on Lattice Power Transmission Towers

AbstractThe use of composite materials on a structural engineering area is increasing every day because of the advantages of these materials over conventional materials. In countries like the United States, India, and China, structures made only from polymeric materials for electric energy transmission have been developed. However, there is no reported experience for substituting metallic members with composite elements on lattice power transmission towers. In this work, a methodology for evaluating the feasibility of replacing metallic members with composite members in lattice power transmission towers is presented. The methodology is on the basis of an analysis of the maximum compressive stress than can be developed along the metallic members constituting the inferior zone of a power transmission tower. The obtained results show that four polymeric material alternatives could be considered to manufacture composite members to replace metallic members, which are stolen or removed for some reason. It is po.
Perindopril protects against streptozotocin-induced hyperglycemic myocardial damage/alterations

High blood pressure, obesity, abnormal lipid profile, which often coexist with diabetes, tend to be associated with preclinical cardiovascular abnormalities and may contribute to the association of diabetes with cardiovascular events. Many studies have proved that streptozotocin (STZ) is responsible for type-2-diabetes-induced cardiovascular complications. Long-term perindopril therapy in patients with hypertension and diabetes has been observed to correct carotid remodeling by reducing hypertrophy. We studied the effect of perindopril (1 mg/kg/d orally [po]) on cardiovascular complications in neonatal model of rats, which was induced by administering STZ (90 mg/kg, intraperitoneally [ip]), in 5-d-old wistar rats and cardiac hypertrophy induced by isoprenaline (ISO; 5 mg/kg, ip) for 10 d. Various biochemical, cardiac, and hemodynamic parameters were measured at the end of 8 weeks of treatment in diabetes model and 10 d in hypertrophy model. STZ produced hyperglycemia, hyperinsulinemia, dyslipidemia, hypertension, bradycardia, increased creatinine kinase (CK-MB), lactate dehydrogenase enzymes (LDH) and C-reactive protein (CRP) levels, cardiac hypertrophy, and oxidative stress. Chronic treatment with perindopril significantly prevented STZ-induced hyperglycemia and hyperinsulinemia and controlled dyslipdemia in diabetic rats. Further, perindopril produced a significant reduction in elevated levels of CRP, LDH, and CK. STZ-induced hypertension and bradycardia were also prevented by perindopril treatment. Perindopril also produced beneficial effect by preventing cardiac hypertrophy as evident from cardiac hypertrophy index and left ventricular hypertrophic index. Perindopril also prevented STZ-induced oxidative stress. Similar results were obtained in ISO-induced cardiac hypertrophic model, which confirms the beneficial role of perindopril in cardiac hypertrophy. In conclusion, our data from both studies suggest that perindopril produced beneficial effect on cardiac complications.
CD70: A Potential Target in Breast Cancer?

CD70 is a co-stimulatory molecule involved in the immune response and also in cancer development and progression. Recent studies show that high CD70 expression in cancer cells may inhibit the anti-tumor response. Furthermore, CD70 expression has been reported as a predictive marker of resistance to chemotherapy in ovarian cancers. Some in vitro studies have shown that CD70 expression is epigenetically down-regulated through hypermethylation of its promoter during tumoral progression. This study evaluated the level of CD70 expression in surgical samples of breast invasive tumors and determined its correlation with CD70 promoter methylation. Twenty “luminal A” and 20 “basal-like” frozen samples from early breast tumors were retrospectively selected. CD70 expression was evaluated by quantitative real-time PCR. Total DNA was bisulfite-treated, and methylation levels of 5 consecutive CG sites present in the proximal region (-464, -421) of the promoter were assessed by pyrosequencing analysis. Statistical analyses were performed using the Mann-Whitney test. The median relative CD70 expression level was 0.37 and was significantly higher in the basal-like group (0.78 [0.24-31.7]) compared to the luminal A group (0.25 [0.03-1.83], p=0.0001). The median methylation level was 61%, with no significant difference between the basal-like (63%) and luminal A (58%) groups. No correlation was found between CD70 expression and CD70 methylation level. In this study, higher CD70 expression was observed in the basal-like group, but this expression was not related to promoter methylation. The higher expression in the poor-prognosis subgroup of patients makes CD70 a potential target for emerging anti-CD70 therapies.
The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection

ABSTRACT Saliva from arthropod vectors facilitates blood feeding by altering host inflammation. Whether arthropod saliva counters inflammasome signaling, a protein scaffold that regulates the activity of caspase-1 and cleavage of interleukin-1β (IL-1β) and IL-18 into mature molecules, remains elusive. In this study, we provide evidence that a tick salivary protein, sialostatin L2, inhibits inflammasome formation during pathogen infection. We show that sialostatin L2 targets caspase-1 activity during host stimulation with the rickettsial agent Anaplasma phagocytophilum. A. phagocytophilum causes macrophage activation and hemophagocytic syndrome features. The effect of sialostatin L2 in macrophages was not due to direct caspase-1 enzymatic inhibition, and it did not rely on nuclear factor κB or cathepsin L signaling. Reactive oxygen species from NADPH oxidase and the Loop2 domain of sialostatin L2 were important for the regulatory process. Altogether, our data expand the knowledge of immunoregulatory pathways of tick salivary proteins and unveil an important finding in inflammasome biology.
SparkSW: Scalable Distributed Computing System for Large-Scale Biological Sequence Alignment

The Smith-Waterman (SW) algorithm is universally used for a database search owing to its high sensitively. The widespread impact of the algorithm is reflected in over 8000 citations that the algorithm has received in the past decades. However, the algorithm is prohibitively high in terms of time and space complexity, and so poses significant computational challenges. Apache Spark is an increasingly popular fast big data analytics engine, which has been highly successful in implementing large-scale data-intensive applications on commercial hardware. This paper presents the first ever reported system that implements the SW algorithm on Apache Spark based distributed computing framework, with a couple of off-the-shelf workstations, which is named as SparkSW. The scalability and load-balancing efficiency of the system are investigated by realistic ultra-large database from the state-of-the-art UniRef100. The experimental results indicate that 1) SparkSW is load-balancing for parallel adaptive on workloads and scales extremely well with the increases of computing resource, 2) SparkSW provides a fast and universal option high sensitively biological sequence alignments. The success of SparkSW also reveals that Apache Spark framework provides an efficient solution to facilitate coping with ever increasing sizes of biological sequence databases, especially generated by second-generation sequencing technologies.
LIPTUS: associating structured and unstructured information in a banking environment

Growing competition has made today's banks understand the value of knowing their customers better. In this paper, we describe a tool, LIPTUS, that associates the customer interactions (emails and transcribed phone calls) with customer and account profiles stored in an existing data warehouse. The associations discovered by LIPTUS enable analytics spanning the customer and account profiles on one hand and the meta-data associated or derived from the interaction (using text mining techniques) on the other. We illustrate the value derived from this consolidated analysis through specific customer intelligence applications. LIPTUS is today being extensively used in a large bank in India. A highlight of this paper is a discussion of the technical challenges encountered while building LIPTUS and deploying it on real-life customer data.
Ultrasound-Guided Cannulation and Endocavitary Electrocardiography Placement of Internal Jugular Vein Catheters in Uremic Patients: The Importance of Routine Chest X-Ray Evaluation

The NKF-DOQI guidelines recommend performing chest-X-ray(CXR) after subclavian and internal jugular vein insertion prior to catheter use. This is to exclude complications such as a pneumothorax before starting hemodialysis. Indication of a central venous dialysis catheter was based on the historic use of the subclavian vein for placement of these catheters and upon the reported incidence of pneumothorax after this approach of between 1% to 12.4%. In contrast, the incidence of these complications using the internal jugular vein (IJV) is much lower (< 1%). We report our experience in ultrasound-guided cannulation of the right IJV for dialysis vascular access in 527 uremic patients and central catheter placement by endocavitary electrocardiography (EC-ECG). Fluoroscopy was not utilized. In the first hundred cases, all patients underwent CXR. Subsequently, because of total absence of complications and catheter tip malpositioning, the CXR control was carried out only in selected cases (repeated cannulation of the jugular vein or absence of P wave). We believe that only in selected cases should a pCXR be performed before starting hemodialysis sessions, and that our method using the right IJV, ultrasound-guided puncture of the vessel, and catheter placement by EC-ECG is a safe and simple technique that avoids the need for CXR control.
Searching for a k-Clique in Unknown Graphs

Agents that solve problems in unknown graphs are usually required to iteratively explore parts of the graph. In this paper we research the problem of finding a k-clique in an unknown graph while minimizing the number of required exploration actions. Two novel heuristics Known Degree and Clique* are proposed to reduce the required exploration cost by carefully choosing which part of the environment to explore. We further investigate the problem by adding probabilistic knowledge of the graph and propose an Markov Decision Process(MDP) and a Monte Carlo based heuristic (RClique*) that uses knowledge of edge probabilities to reduce the required exploration cost. We demonstrate the efficiency of the proposed approaches on simulated random and scale free graphs as well as on real online web crawls.
Intracellular organization of bacteriophage T7 DNA: analysis of parenteral bacteriophage T7 DNA-membrane and DNA-protein complexes

After infection of Escherichia coli with bacteriophage T7, the parenteral DNA forms a stable association with host cell membranes. The DNA-membrane complex isolated in cesium chloride gradients is free of host DNA and the bulk of T7 RNA. The complex purified through two cesium chloride gradients contains a reproducible set of proteins which are enriched in polypeptides having molecular weights of 54,000, 34,000, and 32,000. All proteins present in the complex are derived from host membranes. Treatment of the complex with Bruij-58 removes 95% of the membrane lipid and selectively releases certain protein components. The Brij-treated complex has an S value of about 1,000 and the sedimentation rate of this material is not altered by treatment with Pronase or RNase.
Monkey in the middle: monkeys serve as amplification hosts but not reservoir hosts of sylvatic chikungunya virus

Background Novel pathogens can emerge into humans via one-step transmission from a reservoir host, an animal species in which the pathogen is maintained, or a two-step process in which the pathogen is transmitted from the reservoir host into a different amplification host species and thence to humans. Here we use serosurveillance and mathematical modeling to discover whether monkeys serve as reservoir or amplification hosts for mosquito-borne chikungunya virus (CHIKV). CHIKV invaded the Americas in 2013, and our study provides key data for predicting whether and where CHIKV will establish enzootic transmission among animal hosts in the New World. ∗To whom correspondence should be addressed. Email: balthouse@idmod.org †These authors contributed equally to this work.
Oncogenes and Tumor Suppressors Human Lung Epithelial Cells Progressed to Malignancy through Speci fi c Oncogenic Manipulations

We used CDK4/hTERT–immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common lung cancer oncogenic changes (p53, KRAS, and MYC) and followed the stepwise transformation of HBECs to full malignancy. This model showed that: (i) the combination of five genetic alterations (CDK4, hTERT, sh-p53,KRAS, and c-MYC) is sufficient for full tumorigenic conversion of HBECs; (ii) genetically identical clones of transformed HBECs exhibit pronounced differences in tumor growth, histology, and differentiation; (iii) HBECs from different individuals vary in their sensitivity to transformation by these oncogenicmanipulations; (iv) high levels of KRAS are required for full malignant transformation of HBECs, however, prior loss of p53 function is required to prevent oncogene-induced senescence; (v) overexpression of c-MYC greatly enhances malignancy but only in the context of sh-p53þKRAS; (vi) growth of parental HBECs in serum-containing medium induces differentiation, whereas growth of oncogenically manipulated HBECs in serum increases in vivo tumorigenicity, decreases tumor latency, produces more undifferentiated tumors, and induces epithelial-to-mesenchymal transition (EMT); (vii) oncogenic transformation of HBECs leads to increased sensitivity to standard chemotherapy doublets; (viii) an mRNA signature derived by comparing tumorigenic versus nontumorigenic clones was predictive of outcome in patients with lung cancer. Collectively, our findings show that this HBEC model system can be used to study the effect of oncogenic mutations, their expression levels, and serum-derived environmental effects in malignant transformation, while also providing clinically translatable applications such as development of prognostic signatures and drug response phenotypes. Mol Cancer Res; 11(6); 1–13. 2013 AACR.
Towards a theory of leadership practice: a distributed perspective

School‐level conditions and school leadership, in particular, are key issues in efforts to change instruction. While new organizational structures and new leadership roles matter to instructional innovation, what seems most critical is how leadership practice is undertaken. Yet, the practice of school leadership has received limited attention in the research literature. Building on activity theory and theories of distributed cognition, this paper develops a distributed perspective on school leadership as a frame for studying leadership practice, arguing that leadership practice is constituted in the interaction of school leaders, followers, and the situation.
The privileged normalization of marijuana use – an analysis of Canadian newspaper reporting, 1997–2007

The objective of this study was to systematically examine predominant themes within mainstream media reporting about marijuana use in Canada. To ascertain the themes present in major Canadian newspaper reports, a sample (N = 1999) of articles published between 1997 and 2007 was analyzed. Drawing from Manning’s theory of the symbolic framing of drug use within media, it is argued that a discourse of ‘privileged normalization’ informs portrayals of marijuana use and descriptions of the drug’s users. Privileged normalization implies that marijuana use can be acceptable for some people at particular times and places, while its use by those without power and status is routinely vilified and linked to deviant behavior. The privileged normalization of marijuana by the media has important health policy implications in light of continued debate regarding the merits of decriminalization or legalization and the need for public health and harm reduction approaches to illicit drug use.
A Risk Explicit Interval Linear Programming Model for Uncertainty-Based Environmental Economic Optimization in the Lake Fuxian Watershed, China

The conflict of water environment protection and economic development has brought severe water pollution and restricted the sustainable development in the watershed. A risk explicit interval linear programming (REILP) method was used to solve integrated watershed environmental-economic optimization problem. Interval linear programming (ILP) and REILP models for uncertainty-based environmental economic optimization at the watershed scale were developed for the management of Lake Fuxian watershed, China. Scenario analysis was introduced into model solution process to ensure the practicality and operability of optimization schemes. Decision makers' preferences for risk levels can be expressed through inputting different discrete aspiration level values into the REILP model in three periods under two scenarios. Through balancing the optimal system returns and corresponding system risks, decision makers can develop an efficient industrial restructuring scheme based directly on the window of “low risk and high return efficiency” in the trade-off curve. The representative schemes at the turning points of two scenarios were interpreted and compared to identify a preferable planning alternative, which has the relatively low risks and nearly maximum benefits. This study provides new insights and proposes a tool, which was REILP, for decision makers to develop an effectively environmental economic optimization scheme in integrated watershed management.
Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

Genetic analysis reveals the complex history of sub-Saharan Africans and African Americans. On the history of Bantu speakers Africans are underrepresented in many surveys of genetic diversity, which hinders our ability to study human evolution and the health of modern populations. Patin et al. examined the genetic diversity of Bantu speakers, who account for one-third of sub-Saharan Africans. They then modeled the timing of migration and admixture during the Bantu expansion. The analysis revealed adaptive introgression of genes that likely originated in other African populations, including specific immune-related genes. Applying this information to African Americans suggests that gene flow from Africa into the Americas was more complex than previously thought. Science, this issue p. 543 Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans.