Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity and reliability of the South African health promoting schools monitoring questionnaire

Summary Health promoting schools, as conceptualised by the World Health Organisation, have been developed in many countries to facilitate the health-education link. In 1994, the concept of health promoting schools was introduced in South Africa. In the process of becoming a health promoting school, it is important for schools to monitor and evaluate changes and developments taking place. The Health Promoting Schools (HPS) Monitoring Questionnaire was developed to obtain opinions of students about their school as a health promoting school. It comprises 138 questions in seven sections: socio-demographic information; General health promotion programmes; health related Skills and knowledge; Policies; Environment; Community-school links; and support Services. This paper reports on the reliability and face validity of the HPS Monitoring Questionnaire. Seven experts reviewed the questionnaire and agreed that it has satisfactory face validity. A test-retest reliability study was conducted with 83 students in three high schools in Cape Town, South Africa. The kappa-coefficients demonstrate mostly fair (κ-scores between 0.21 and 0.4) to moderate (κ-scores between 0.41 and 0.6) agreement between test-retest General and Environment items; poor (κ-scores up to 0.2) agreement between Skills and Community test-retest items, fair agreement between Policies items, and for most of the questions focussing on Services a fair agreement was found. The study is a first effort at providing a tool that may be used to monitor and evaluate students’ opinions about changes in health promoting schools. Although the HPS Monitoring Questionnaire has face validity, the results of the reliability testing were inconclusive. Further research is warranted.
Is there a Benefit to Use Calculated Percent Body Fat or Age- and Gender-adjusted BMI-SDSLMS to Predict Risk Factors for Cardiovascular Disease? A German/Austrian Multicenter DPV-Wiss Analysis on 42 048 Type 2 Diabetic Patients

Abstract Objective: In clinical practice Body Mass Index is generally used to evaluate overweight status in adults. The present multicenter study examines whether Body Mass Index (BMI), age- and gender-adjusted Body Mass Index Standard Deviation Score, or calculated %body fat is a better predictor for cardiovascular disease risk factors, specifically hypertension and dyslipidemia, in a high-risk population. Methods: Data of 42 048 adult type 2 diabetic patients (median age: 67.1 years) from 161 centers in Germany (n=158) and Austria (n=3) registered in a standardized, prospective, computer-based documentation program, were included in the study. For each patient body weight, height, blood pressure and blood lipids were documented. Spearman correlation analyses as well as multivariable logistic regression models were used to examine the relationship between anthropometric measurements and cardiovascular disease risk factors. Results: Correlation and regression analyses revealed minor, non significant differences between the 3 anthropometric measurements (all p>0.05). In both genders, relationships between anthropometric measurements and hypertension or reduced HDL-cholesterol were nearly identical. Only for increased triglycerides, the relations with the 3 anthropometric measurements were significantly stronger in males than in females (p<0.0001, respectively). With increasing age, associations between anthropometric measurements and hypertension, reduced HDL-cholesterol or increased triglycerides became weaker. Spearman correlation coefficients for total cholesterol and LDL-cholesterol revealed weak associations with the 3 anthropometric measurements. Conclusion: Compared to Body Mass Index, age- and gender-adjusted Body Mass Index Standard Deviation Score, or calculation of %body fat, has no further benefit to predict cardiovascular disease risk factors in adult type 2 diabetic patients.
Characterization of two novel adenomatous polyposis coli (APC) gene mutations in patients with familial adenomatous polyposis (FAP)

Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra‐colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline DNA of 81 unrelated FAP patients and evaluated correlation of APC mutation genotype and clinical phenotype. Germline APC mutations were identified in 18 FAP patients including two novel 2 bp deletions at APC codons 1067 and 1259. FAP patients were screened for hypertrophic ocular fundus lesions, desmoids and peri‐ampullary adenomas. As reported previously (Olshwang et al 1993b), a positive correlation for the frequency of retinal lesions and germline APC mutation was observed among all FAP patients except one. No significant correlation was observed for APC mutation genotype and the occurrence of desmoids and peri‐ampullary adenomas. Genetic factors contributing to familial segregation of these lesions need further investigation. © 1994 Wiley‐Liss, Inc.
The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE Gene Family Is Required for Osmotic Stress Tolerance and Male Sporogenesis1[C][W][OA]

TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins are characterized by the presence of six tetratricopeptide repeats in conserved positions and a carboxyl-terminal region known as the thioredoxin-like domain with homology to thioredoxins. In Arabidopsis (Arabidopsis thaliana), the TTL gene family is composed by four members, and the founder member, TTL1, is required for osmotic stress tolerance. Analysis of sequenced genomes indicates that TTL genes are specific to land plants. In this study, we report the expression profiles of Arabidopsis TTL genes using data mining and promoter-reporter β-glucuronidase fusions. Our results show that TTL1, TTL3, and TTL4 display ubiquitous expression in normal growing conditions but differential expression patterns in response to osmotic and NaCl stresses. TTL2 shows a very different expression pattern, being specific to pollen grains. Consistent with the expression data, ttl1, ttl3, and ttl4 mutants show reduced root growth under osmotic stress, and the analysis of double and triple mutants indicates that TTL1, TTL3, and TTL4 have partially overlapping yet specific functions in abiotic stress tolerance while TTL2 is involved in male gametophytic transmission.
Move fast, travel slow: the influence of high-speed rail on tourism in Taiwan

ABSTRACT High-speed rail (HSR) and tourism are closely related economic activities because improved mobility is perceived to facilitate tourist behavioral changes. This study examines the influence of HSR on the travel patterns of individual tourists in Taiwan in relation to time, space and carbon emissions. A framework is first provided to discuss how changes in the speed of intercity transportation will affect visitors’ choice of the journey, behavior at destinations and trip quality. In addition, HSR is expected to influence five general aspects of travel decisions relating to mobility and trip emissions, including mode selection, travel distance, length of stay per trip, annual travel frequency and total travel days. In the example of Taiwan, information by onsite sampling of 400 domestic travelers found that HSR had a weak influence on travel distance and length of stay per trip, but was observed to facilitate extended time at each stop, a deeper engagement with the locality, and an approximate 10% reduction in transport carbon emissions through intermodal substitution. These phenomena are in line with the slow travel concept of sustainable tourism consumption.
Scene Classification Based on the Fully Sparse Semantic Topic Model

In high spatial resolution (HSR) imagery scene classification, it is a challenging task to recognize the high-level semantics from a large volume of complex HSR images. The probabilistic topic model (PTM), which focuses on modeling topics, has been proposed to bridge the so-called semantic gap. Conventional PTMs usually model the images with a dense semantic representation and, in general, one topic space is generated for all the different features. However, this approach fails to consider the sparsity of the semantic representation, the classification quality, as well as the time consumption. In this paper, to solve the above problems, a fully sparse semantic topic model (FSSTM) framework is proposed for HSR imagery scene classification. FSSTM, with an elaborately designed modeling procedure, is able to represent the image with sparse but representative semantics. Based on this framework, the topic weights of multiple features are exploited by solving a concave maximization problem, which improves the fusion of the discriminative semantic information at the topic level. Meanwhile, the sparsity and representativeness of the topics generated by FSSTM guarantee that the image is adaptive to the change of a topic number. FSSTM can consistently achieve a good performance with a limited number of training samples, and is robust for HSR image scene classification. The experimental results obtained with three different types of HSR image data sets confirm that the proposed algorithm is effective in improving the performance of scene classification, and is highly efficient in discovering the semantics of HSR images when compared with the state-of-the-art PTM methods.
Disabling dissent: the colour revolutions, autocratic linkages, and civil society regulations in hybrid regimes

ABSTRACT State elites in hybrid regimes have increasingly sought to manipulate the legal regulation of non-governmental organizations (NGOs) as part of the growing backlash against democracy assistance in nondemocratic countries around the world. Sophisticated laws detailing burdensome NGO registration procedures and complex regulations enabling invasive government oversight of NGOs represent upgraded forms of civic curtailment and democracy resistance. This paper analyses these significant developments in a systematic, cross-national fashion over time by constructing a new dataset of NGO legal barriers in hybrid regimes from 1995 to 2013. It demonstrates that the expansion of repressive NGO regulations are shaped by international factors, particularly autocratic linkages, in the form of trade or defence pacts with Russia and China, as well as authoritarian learning from the colour revolutions. It thus contributes to debates on autocracy promotion and authoritarian resurgence by moving beyond the regime level to focus on the sub-regime dimension of freedom of association.
Functional morphology of the secretory pathway organelles in yeast

The glycoprotein secretory pathway of yeast serves mainly for cell surface growth and cell division. It involves a centrifugal transport of transit macromolecules among organelles, whose membranes contain resident proteins needed for driving the transport. These resident membrane proteins return by retrograde vesicular transport. Apart from this, the pathway involves endocytosis. The model yeast Saccharomyces cerevisiae and vertebrate cells were found to contain very similar gene products regulating the molecular mechanism of glycoprotein transport, and the cellular mechanism of their secretion pathways was therefore also presumed to be identical. Biochemists have postulated that, in S. cerevisiae, the translocation of peptides through the endoplasmic reticulum membranes into the lumen of ER cisternae and the core glycosylation is followed by a vector‐mediated transport into the functional cascade of the Golgi system cisternae and between them. This is the site of maturation and sorting of glycoproteins, before the ultimate transport by other vectors involving either secretion from the cells (exocytosis across the plasmalemma into the cell wall) or transport into the lysosome‐like vacuole via a prevacuolar compartment, which serves at the same time as a primary endosome. The established cellular model of secretion deals with budding yeast; interphase yeast cells, in which the secretion is limited and which predominate in exponential cultures, have not been taken into consideration. The quality of organelle imaging in S. cerevisiae ultra‐thin sections depends on the fixation technique used and on specimen contrasting by metals. The results achieved by combinations of different techniques differ mostly in the imaging of bilayers of membrane interfaces and the transparence of the matrix phase. Fixation procedures are decisive for the results of topochemical localisations of cellular antigenic components or enzyme activities, which form the basis of the following survey of functional morphology of organelles involved in the yeast secretory pathway. The existing results of these studies do not confirm all aspects of the vertebrate model of the Golgi apparatus proposed by molecular geneticists to hold for S. cerevisiae, and alternative models of the cellular mechanism of secretion in this yeast are, therefore, also discussed. Microsc. Res. Tech. 51:530–546, 2000. © 2000 Wiley‐Liss, Inc.
Fiscal policy under constraints : fiscal capacity and the (in-)stability of government financing during the Great Depression

The Great Depression, and the interwar period more generally, were characterized by macroeconomic mismanagement. Fiscal policy, in particular, was essentially not used to fight the slump. Despite this, I find that a higher degree of fiscal capacity helped countries reduce the cyclical volatility of their governments' financing and, thus, to run stabilizing ˗ or, at least, less destabilizing ˗ fiscal policies. This smoothing effect worked principally by facilitating countries' access to borrowing. Thus, interwar governments were constrained in their policy choices by past investments in their fiscal systems, and not just Gold Standard membership and ideology, as commonly held in the literature. JEL: N10, N40, E62, H63
The Decline and Resurgence of Turkish Islamism: The Story of Tayyip Erdoğan’s AKP

Abstract For decades, Turkish Islamists have failed to attract the votes of large sections of society and remained marginal. As a result of this failure to come to power, and due to domestic and international constraints and windows of opportunities, they have declared that they have jettisoned Islamism. Many Turkish Muslims whose religious disposition was shaped by the pluralistic urban Ottoman experience and small-town Anatolian traditionalism, and by the contesting currents of cosmopolitan pluralism and rural social conservatism, voted in favour of these former Islamists who have become “Muslim Democrats”. This paper elaborates on the genealogy of Turkish Islamists and their political trajectories and argues that when the forces and constraints of domestic and external social, political and economic conditions disappeared and the opportunities derived from being Muslim Democrats no longer existed, the former Islamists easily returned to their original ideology, showing that despite assertions to the contrary their respect for democracy and pluralism had not truly been internalised. This paper also aims to demonstrate that similar to other authoritarian populists, Erdoganists perceive the state and its leader as more important than anything else and as being above everything else, which has culminated in a personality cult and sanctification of the state. As long as Turkey’s economy continued to boom, almost everyone was happy that Turkey could readily market the “Muslim Democrats” story to the whole world for a long period as a major success story, or as an “exemplary Muslim country” or “model”. Yet, Middle Eastern elites and Western forces got carried away and learnt the hard way just how naive their view was in perhaps the first great transformation movement of the twenty-first century – the Arab Spring. Likewise, the Turkish Spring turned all too quickly towards autumn and then winter.
Variation Aware Analysis of Bridging Fault Testing

This paper investigates the impact of process variation on test quality with regard to resistive bridging faults. The input logic threshold voltage and gate drives strength parameters are analyzed regarding their process variation induced influence on test quality. The impact of process variation on test quality is studied in terms of test escapes and measured by a robustness metric. It is shown that some bridges are sensitive to process variation in terms of logic behavior, but such variation does not necessarily compromise test quality if the test has high robustness. Experimental results of Monte-Carlo simulation based on recent process variation statistics are presented for ISCAS85 and -89 benchmark circuits, using a 45 nm gate library and realistic bridges. The results show that tests generated without consideration of process variation are inadequate in terms of test quality, particularly for small test sets. On the other hand, larger test sets detect more of the logic faults introduced by process variation and have higher test quality.
Regulated expression of pathogen‐associated molecular pattern molecules in Staphylococcus epidermidis: quorum‐sensing determines pro‐inflammatory capacity and production of phenol‐soluble modulins

Phenol‐soluble modulin (PSM) is a peptide complex produced by the nosocomial pathogen Staphylococcus epidermidis that has a strong capacity to activate the human innate immune response. We developed a novel method based on liquid chromatography‐mass spectrometry (LC‐MS) to quantify the production of the individual PSM components. Each PSM peptide was abundant in most of the 76 S epidermidis strains tested. Importantly, none of the PSM components were secreted by an agr mutant strain, indicating that PSM synthesis is regulated strictly by the agr quorum‐sensing system. Furthermore, the agr mutant strain failed to elicit production of TNFα by human myeloid cells and induced significantly less neutrophil chemotaxis compared with the wild‐type strain. Thus, quorum‐sensing in S. epidermidis dramatically influenced activation of human host defence. We propose that an agr quorum‐sensing mechanism facilitates growth and survival in infected hosts by adapting production of the pro‐inflammatory PSMs to the stage of infection.
Effect of tunicamycin on the synthesis of herpes simplex virus type 1 glycoproteins and their expression on the cell surface

Herpes simplex virus specifies five glycoproteins which have been found on the surface of both the intact, infected cells and the virion envelope. In the presence of the drug tunicamycin, glycosylation of the herpes simplex virus type 1 glycoproteins is inhibited. We present in this report evidence that the immunologically specificity of the glycoproteins designated gA, gB, and gD resides mainly in the underglycosylated "core" proteins, as demonstrated by the immunoblotting technique. We showed also that tunicamycin prevented exposure of the viral glycoproteins on the cell surface, as the individual glycoproteins lost their ability to participate as targets for the specific antibodies applied in the antibody-dependent, cell-mediated cytotoxicity test. Immunocytolysis was reduced between 73 and 97%, depending on the specificity of the antibodies used. The intracellular processing of the herpes simplex virus type 1-specific glycoprotein designated gC differed from the processing of gA, gB, and GD, as evidenced by the identification of an underglycosylated but immunochemically modified form of gC on the surface of infected cells grown in the presence of tunicamycin.
Preclinical and clinical evaluation of elotuzumab, a SLAMF7-targeted humanized monoclonal antibody in development for multiple myeloma

Although multiple myeloma has historically been treated with chemotherapy, prolonged survival has only been possible since the introduction of thalidomide, lenalidomide and bortezomib. However, multiple myeloma remains largely incurable, and new treatments are needed to improve long-term outcome. Elotuzumab is a humanized IgG1 monoclonal antibody that targets Signaling Lymphocyte Activation Molecule Family member 7 (SLAMF7) to activate NK cells, enabling selective killing of myeloma cells with minimal effects on normal tissue. The combination of elotuzumab with antimyeloma therapies that stimulate host immunity may be an attractive treatment option for patients with newly diagnosed or relapsed/refractory multiple myeloma. Here, we review the role of SLAMF7 in the pathogenesis of multiple myeloma and the preclinical and clinical development of elotuzumab.
Alcohol and Drug Use and Related Disorders: An Underrecognized Health Issue Among Adolescents and Young Adults Attending Sexually Transmitted Disease Clinics

Objectives: The objectives of this study were to describe patterns of alcohol and drug use disorders among young persons attending a public sexually transmitted disease (STD) clinic and to determine their associations with sexual risk behaviors and STDs. Study Design: Four hundred forty-eight men and women aged 15 to 24 who were attending an urban STD clinic completed an interviewer-administered questionnaire that assessed a broad range of substance use in general and for alcohol and marijuana use disorders. Results: Overall, 42.9% had an alcohol or marijuana use disorder (51.6% of males and 34.2% of females), whereas 30.6% had a confirmed STD. Participants with a substance use disorder were significantly more likely to have multiple sexual partners (odds ratio [OR] = 2.3; 95% confidence interval [CI] = 1.5–3.4), to be inconsistent condom users (OR = 3.1; 95% CI = 1.5–6.3), and to have an STD (OR = 1.7; 95% CI = 1.1–2.6). Conclusions: Among young STD clinic attendees, substance use disorders were more common than confirmed STDs. STD clinics may be an appropriate setting to screen for and address substance use disorders in young persons.
Analyses of Comparative Gaze with Eye-Tracking Technique for Peer-Reviewing Classrooms

This paper focuses on peer-reviewing classrooms, which is a helpful activity for teachers to improve teaching skills, involving students in their course, and using chalks and slides better. This kind of activities mainly consists of a lecture that is open to other teachers and a reflective discussion with the teachers after the lecture. In order to encourage such activities and make them more fruitful, we introduced an eye-tracking technique to understand visual attention of the experts on the actual classroom observations. Beginners on classroom observations are also measured and compared with the experts. From the results of the experiments, a trend of comparative gaze on the elements in classroom like the teacher, the slides, and the students is typically found among the experts. Peer-reviewing with recorded video files from four angles is also being evaluated. These trends may be applied to training programs in faculty development.