Miracle-dz/UniFAR-FTUs huggingface dataset:
A Numerical Approach to the Diagnostics of Electrical Distribution Networks

In order to ascertain the state of electrical distribution networks, a numerical approach is suggested based on a continuous monitoring of network impedances, whose changes are usefully interpreted for diagnostic purposes. Accurate diagnostics procedures allow to schedule effective preventive maintenance with cost reduction and an improvement in the supply continuity level. First the proposed method performs a computation of the impedances and then classifies network elements, which are automatically assigned one of the following states: good, weak or faulted. The necessary diagnostic information is obtained from a designed network stimulation whose responses are previously acquired, pre-processed by a measurement system and then sent to a data processing center. The implemented algorithm performs a real-time network diagnosis by solving a linear equation system properly developed to calculate network parameters. A virtual test network was used to validate the method through proper numerical simulations performed by means of the Simulink Mat-Lab code. The mathematical model applied is thoroughly described and the various conditions to obtain consistent solutions are properly demonstrated.
The SecY membrane component of the bacterial protein export machinery: analysis by new electrophoretic methods for integral membrane proteins.

The product of the secY (prlA) gene (the SecY protein) involved in protein export in Escherichia coli was overproduced and localized in the cytoplasmic (inner) membrane. Because of its strong interaction with a non‐ionic detergent (NP40), it partitioned into the detergent layer during electroblotting through a NP40‐containing gel (detergent blotting), and it formed a horizontal streak in the O'Farrell two‐dimensional gel electrophoretic system. Consequently, we developed an alternative two‐dimensional gel procedure, which proved useful for analysis of integral membrane proteins, especially in combination with detergent blotting. SDS‐gel electrophoresis was carried out successively through gels of lower (first dimension) and higher (second dimension) sieving effects. Many membrane proteins, unlike soluble proteins, formed spots off and above the diagonal line, and all of these spots partitioned exclusively into the detergent layer. A characteristic pattern of integral membrane proteins of E. coli was thus obtained and the spot of the SecY protein in the cytoplasmic membrane was identified even when it was not overproduced. These results show that the gene secY specifies an integral membrane component of the protein export machinery.
Development of gray-zone deterrence: concept building and lessons from Japan’s experience

Abstract In contemporary international security, some powers try to challenge the status quo through gradual, sub-threshold expansion without resorting to the explicit use of force. Examples of such sub-threshold challenges can be seen in the East China Sea, the South China Sea, and Eastern Europe. They are now referred to as ‘gray zone’ or ‘hybrid threat’. For a long time deterrence theory, a core component of strategic studies, has largely neglected such sub-threshold challenges. The exceptional part of that is empirical school’s findings, including fait accompli, limited probe, and controlled pressure. They perfectly match with the current threats and help developing conceptual framework to deter these kind of threats. Based on these findings, this paper attempted to illustrate three principles for gray zone deterrence: combination of deterrence by denial and deterrence by punishment, mobilization of the whole government assets, and keeping open the window to escalation and analyze, Japan’s efforts to develop conceptual framework for gray zone deterrence. Since Japan’s efforts to develop conceptual framework of gray zone deterrence dates further back than other part of the world, as the National Defense Program Guidelines (NDPG) of 2010, a case study on Japan would provide useful insights for gray zone deterrence.
P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples

Bevacizumab in combination with carboplatin and paclitaxel improves overall response and survival in patients with advanced or recurrent nonsmall cell lung carcinoma. However, this drug is not recommended in patients with squamous cell carcinoma or neoplasms with a dominant squamous component. Therefore, identification of squamous cell differentiation has therapeutic implications. In many instances, cytology is the diagnostic tool of choice; however, routine cytomorphology is limited in classification of nonsmall cell carcinomas into squamous and nonsquamous subtypes. The aim of this study was to identify the value of p63 immunocytochemical analysis in this distinction.
A LED light control system design by optimal data transfer control algorithm

In this paper, we propose a LED light control system design by optimal data transfer control algorithm. The proposed LED light control systems were to uses an efficient algorithm that simultaneously enables the transfer control of data by comparing the tolerance range of the sensing data on multiple sensor nodes, as the data processing method for the transfer control of sensor data. In addition, the control module of the LED streetlight was designed to handle three different tasks for the RTOS-based lighting control. The system execution status was verification porting directly to the ATmega128 MCU to validate the system, and luminance distribution and operating conditions were verified through LED Street-field testing. An optimal multi sensor data transfer control algorithm of the proposed LED light control systems could alleviate the bottleneck that is concentrated on the sink node using the gateway based WLAN on the multi sensor data transfer control algorithm, and it could to reduce the power consumption of terminal node. In addition, it provides improved system performance the use of an optimal multi sensor data transfer control algorithm that ensures independence by delegation to each task module, and was able to optimize energy saving using an intelligent lighting pattern control system.
The Effect of Self-Set Grade Goals and Core Self-Evaluations on Academic Performance: A Diary Study

The aim of this diary study was to examine the eff ect of self-set grade goals and core self-evaluations on academic performance. Data were collected among 59 university students (M age = 18.4 yr., SD = 0.8) In a 2-wk. exam period on up to five exam days. Multilevel analyses revealed that the individual grade goals students set for their exams were positively related to the grades they obtained for these exams. However, the goal–performance relationship only applied to students scoring high on core self-evaluations. The results of this study contribute to the understanding of the effect of self-set grade goals and core self-evaluations on academic performance and imply important practical applications to enhance academic performance.
Demographic-Based Content Analysis of Web-Based Health-Related Social Media

Background An increasing number of patients from diverse demographic groups share and search for health-related information on Web-based social media. However, little is known about the content of the posted information with respect to the users’ demographics. Objective The aims of this study were to analyze the content of Web-based health-related social media based on users’ demographics to identify which health topics are discussed in which social media by which demographic groups and to help guide educational and research activities. Methods We analyze 3 different types of health-related social media: (1) general Web-based social networks Twitter and Google+; (2) drug review websites; and (3) health Web forums, with a total of about 6 million users and 20 million posts. We analyzed the content of these posts based on the demographic group of their authors, in terms of sentiment and emotion, top distinctive terms, and top medical concepts. Results The results of this study are: (1) Pregnancy is the dominant topic for female users in drug review websites and health Web forums, whereas for male users, it is cardiac problems, HIV, and back pain, but this is not the case for Twitter; (2) younger users (0-17 years) mainly talk about attention-deficit hyperactivity disorder (ADHD) and depression-related drugs, users aged 35-44 years discuss about multiple sclerosis (MS) drugs, and middle-aged users (45-64 years) talk about alcohol and smoking; (3) users from the Northeast United States talk about physical disorders, whereas users from the West United States talk about mental disorders and addictive behaviors; (4) Users with higher writing level express less anger in their posts. Conclusion We studied the popular topics and the sentiment based on users' demographics in Web-based health-related social media. Our results provide valuable information, which can help create targeted and effective educational campaigns and guide experts to reach the right users on Web-based social chatter.
Muscarinic control of graded persistent activity in lateral amygdala neurons

The cholinergic system is crucially involved in several cognitive processes including attention, learning and memory. Muscarinic actions have profound effects on the intrinsic firing pattern of neurons. In principal neurons of the entorhinal cortex (EC), muscarinic receptors activate an intrinsic cation current that causes multiple self‐sustained spiking activity, which represents a potential mechanism for transiently sustaining information about novel items. The amygdala appears to be important for experience‐dependent learning by emotional arousal, and cholinergic muscarinic influences are essential for the amygdala‐mediated modulation of memory. Here we show that principal neurons from the lateral nucleus of the amygdala (LA) can generate intrinsic graded persistent activity that is similar to EC layer V cells. This firing behavior is linked to muscarinic activation of a calcium‐sensitive non‐specific cation current and can be mimicked by stimulation of cholinergic afferents that originate from the nucleus basalis of Meynert (n. M). Moreover, we demonstrate that the projections from the n. M. are essential and sufficient for the control and modulation of graded firing activity in LA neurons. We found that activation of these cholinergic afferents (i) is required to maintain and to increase firing rates in a graded manner, and (ii) is sufficient for the graded increases of stable discharge rates even without an associated up‐regulation of Ca2+. The induction of persistent activity was blocked by flufenamic acid or 2‐APB and remained intact after Ca2+‐store depletion with thapsigargin. The internal ability of LA neurons to generate graded persistent activity could be essential for amygdala‐mediated memory operations.
Deep Learning for Forecasting

In this virtual workshop, we aim at covering neural forecasting methods from ground up, starting from the very basics of deep learning up to recent forecasting model improvements such as [5]. Given that the workshop is fully virtual, we will primarily rely on lectures. In these, we will focus on the fundamentals of deep learning such as the various architecture types (e.g. feed-forward, convolutional and recurrent neural networks) and the most important breakthroughs that established the strength of neural networks. Then, we will see how deep learning can be applied to forecasting by reviewing several state-of-the-art neural forecasting models (e.g., WaveNet [8], DeepAR [6], NBEATS [3] and the sequence-to-sequence model family [7, 10]). Furthermore, we will dive into recent work that combines neural networks with probabilistic models such as deep state space [4] and deep factor [9] models, and bayesian techniques such as [2]. Finally, we will introduce GluonTS [1], a time series modelling toolkit primarily aimed at forecasting which is available in open-source. To complement the lectures, we will provide notebooks for the workshop participants to interactively explore some of these ideas themselves. Given that the workshop is workshop, this will be self-study largely. Notebooks will rely on GluonTS [1].
Effect of device-guided breathing exercises on blood pressure in patients with hypertension: A randomized controlled trial

Abstract Objective. Hypertension is a chronic disorder with a high prevalence worldwide. Despite considerable efforts, it is sometimes hard to reach treatment goals for blood pressure (BP) with classical treatment options. Reducing breathing frequency has been advocated as a method to reduce BP. Methods. A randomized, single-blind, controlled trial was conducted in 30 non-diabetic patients with hypertension over a period of 9 weeks to evaluate the effect of a device that helps to slow breathing (Resperate®) on BP and quality of life (QoL). The control group listened to music and used no other therapeutic device. Results. There was no significant difference in change in BP between intervention and control; BP –4.2mmHg (95% CI –12.4 to 3.9)/–2.6mmHg (95% CI –8.4 to 3.3). This result did not alter in post hoc analyses, when patients not achieving target breathing frequency (<10 breaths/min) or non-compliant patients were excluded. QoL did not change over time. Conclusions. We found no effect of the Resperate® on BP or QoL compared with the control group. We conclude that, at this moment, this device has no added value in the treatment of hypertension. Trial registration: ClinicalTrials.gov identifier: NCT00594048.
Lifestyles in suburban populations: A systematic review

Background Lifestyle and suburban population are important issues in the field of health. The living conditions of informal settlements can lead to acquisition of an unhealthy lifestyle. Objective This study has been designed to investigate the articles that have been published regarding lifestyle in suburban populations. Methods The present research was a systematic review of studies in databases including Iranmedex, Magiran, SID, Irandoc, PubMed, Google Scholar, Science Direct and Scopus, in 2017. All Persian and English papers written from 2000 to 2017 were evaluated by two reviewers using an advanced search of the databases with keywords related to lifestyles and suburban population. After completion of the search, the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was used to evaluate the articles. Results In total, 19 articles were found to have addressed the lifestyle in suburban populations. The results of these studies showed an unhealthy lifestyle in the most informal settlements. There was no food diversity. Malnutrition was common, especially overweight. The majority of the people did not have enough physical activity, and smoking and alcohol consumption were common, especially in men. Conclusion Studies showed that suburban populations are among the groups that have unfavorable environmental conditions to acquiring healthy lifestyle and maintaining appropriate health. Therefore, developing infrastructure, improving health services (environment, treatment of diseases, reduction of malnutrition and infant mortality, access to safe drinking water and sanitation, improving waste disposal and recycling it), improving education and smoking prevention programs in improving lifestyle is recommended.
Ultra-low-dose CT for left atrium and pulmonary veins imaging using new model-based iterative reconstruction algorithm.

AIMS To evaluate the feasibility of ultra-low-dose CT for left atrium and pulmonary veins using new model-based iterative reconstruction (MBIR) algorithm. METHODS AND RESULTS Two hundred patients scheduled for catheter ablation were randomized into two groups: Group 1 (100 patients, Multidetector row CT (MDCT) with MBIR, no ECG triggering, tube voltage and tube current of 100 kV and 60 mA, respectively) and Group 2 [100 patients, MDCT with adaptive statistical iterative reconstruction algorithm (ASIR), no ECG triggering, and kV and mA tailored on patient BMI]. Image quality, CT attenuation, image noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) of left atrium (LA) and pulmonary veins, and effective dose (ED) were evaluated for each exam and compared between two groups.No significant differences between groups in terms of population characteristics, cardiovascular risk factors, anatomical features, prevalence of persistent atrial fibrillation and image quality score. Statistically significant differences were found between Group 1 and Group 2 in mean attenuation, SNR, and CNR of LA. Significantly, lower values of noise were found in Group 1 versus Group 2. Group 1 showed a significantly lower mean ED in comparison with Group 2 (0.41 ± 0.04 versus 4.17 ± 2.7 mSv). CONCLUSION The CT for LA and pulmonary veins imaging using MBIR is feasible and allows examinations with very low-radiation exposure without loss of image quality.
Corporate Social Responsibility in Global Supply Chains: Deeds Not Words

The disconnect between the lofty aspirations of firms claiming Corporate Social Responsibility (CSR) and their shortcomings in practice have caused some observers to question its usefulness. The fallout from events like the Rana Plaza catastrophe has highlighted some of these shortcomings—namely, deficiencies in how multinational enterprises (MNEs) transact with suppliers in developing countries. Specifically, our paper aims to investigate whether or not MNEs behave hypocritically by examining the alignment of CSR to business practices in MNE affiliates in developing countries. To answer this question, we apply standard ordinary least squares (OLS) techniques to data for over 1000 MNEs that claim to have a CSR ethos. We find that CSR-active enterprises report significantly higher worker wages, ceteris paribus. Local African suppliers benefit from CSR through knowledge transfer, but only when MNEs make tangible investments in supplier development.
Effector‐independent representations of simple and complex imagined finger movements: a combined fMRI and TMS study

Kinesthetic motor imagery and actual execution of movements share a common neural circuitry. Functional magnetic resonance imaging was used in 12 right‐handed volunteers to study brain activity during motor imagery and execution of simple and complex unimanual finger movements of the dominant and the nondominant hand. In the simple task, a flexible object was rhythmically compressed between thumb, index and middle finger. The complex task was a sequential finger‐to‐thumb opposition movement. Premotor, posterior parietal and cerebellar regions were significantly more active during motor imagery of complex movements than during mental rehearsal of the simple task. In 10 of the subjects, we also used transcranial magnetic brain stimulation to examine corticospinal excitability during the same motor imagery tasks. Motor‐evoked potentials increased significantly over values obtained in a reference condition (visual imagery) during imagery of the complex, but not of the simple movement. Imagery of finger movements of either hand activated left dorsal and ventral premotor areas and the supplementary motor cortex regardless of task complexity. The effector‐independent activation of left premotor areas was particularly evident in the simple motor imagery task and suggests a left hemispherical dominance for kinesthetic movement representations in right‐handed subjects.
Mouse Preimplantation Embryos Developed from Oocytes Injected with Round Spermatids or Spermatozoa Have Similar but Distinct Patterns of Early Messenger RNA Expression1

Abstract Quantitative real-time polymerase chain reaction assay was used to compare the temporal transcriptional activation and mRNA removal for a number of genes in mouse embryos derived by round spermatid injection (ROSI) or intracytoplasmic sperm injection. A number of marker genes with widely different cellular functions were analyzed. Similar patterns of activation were found for the transcription factor Oct 4, the translation initiation factor eukaryotic initiation factor 1A, the L1 ribosomal protein, the chromatin modifying protein histone deacetylase 1, the enzyme hypoxanthine phosphoribosyl transferase, the murine endogenous retrovirus-like element, and the repetitive DNA LINE retrotransposons. Expression of the retrovirus-like mobile element intracisternal A particle, however, was markedly elevated from the two-cell to the blastocyst stages in ROSI embryos. Analyses performed for various paternal mRNAs introduced into the oocyte by the round spermatid, including protamines 1 and 2, transition protein 2, ropporin, and glyceraldehydes 3-phosphate dehydrogenase, revealed all were removed from the preimplantation embryos, albeit with distinct temporal patterns.
Fc Gamma Receptor 3A and 2A Polymorphisms Do Not Predict Response to Rituximab in Follicular Lymphoma

Purpose: Preclinical studies suggest that SNPs in the Fc gamma receptor (FCGR) genes influence response to rituximab, but the clinical relevance of this is uncertain. Experimental Design: We prospectively obtained specimens for genotyping in the rituximab extended schedule or re-treatment trial (RESORT) study, in which 408 previously untreated, low tumor burden follicular lymphoma (FL) patients were treated with single agent rituximab. Patients received rituximab in 4 weekly doses and responders were randomized to rituximab re-treatment (RR) upon progression versus maintenance rituximab (MR). SNP genotyping was performed in 321 consenting patients. Results: Response rates to initial therapy and response duration were correlated with the FCGR3A SNP at position 158 (rs396991) and the FCGR2A SNP at position 131 (rs1801274). The response rate to initial rituximab was 71%. No FCGR genotypes or grouping of genotypes were predictive of initial response. A total of 289 patients were randomized to RR (n = 143) or to MR (n = 146). With a median follow-up of 5.5 years, the 3-year response duration in the RR arm and the MR arm was 50% and 78%, respectively. Genotyping was available in 235 of 289 randomized patients. In patients receiving RR (n = 115) or MR (n = 120), response duration was not associated with any FCGR genotypes or genotype combinations. Conclusions: Based on this analysis of treatment-naïve, low tumor burden FL, we conclude that the FCGR3A and FCGR2A SNPs do not confer differential responsiveness to rituximab. Clin Cancer Res; 22(4); 821–6. ©2015 AACR. See related commentary by Cartron et al., p. 787