Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevention of Immune Nephritis by the Small Molecular Weight Immunomodulator Iguratimod in MRL/lpr Mice

Objective This study was performed to investigate the therapeutic effects of iguratimod in a lupus mouse model. Methods Female MRL/lpr mice were treated with iguratimod, vehicle solution or cyclophosphamide. Proteinuria was monitored and kidney injury was blindly scored by a renal pathologist. Serum anti-double-stranded DNA antibodies were monitored by radioimmunoassay. Kidney IgG and CD20 were stained by immunohistochemistry. Splenic lymphocyte phenotypes were analyzed by flow cytometry. BAFF, IL-17A, IL-6, and IL-21 levels in serum and splenic lymphocytes were detected by ELISA or quantitative PCR. Results Compared with the vehicle-treated controls, MRL/lpr mice treated with iguratimod showed less protenuria, less acute pathological lesions and no chronic changes in the kidneys. There were significant differences in glomerular injury and vasculitis scores, as well as in the semi-quantitave analysis of immune complex deposition between the two groups. Disease activity markers in sera (anti-dsDNA antibodies and immunoglobulin levels) were reduced and hypocomplementemia was attenuated. Lymphocyte expression of BAFF, IL-6, IL-17A and IL-21 was decreased. The abnormal splenic B220+ T cell and plasma cell populations in MRL/lpr mice were reduced by iguratimod treatment, with recovery of the total B cell population and inhibition of B cell infiltration of the kidney tissue. The dosage of iguratimod used in this study showed no significant cytotoxic effects in vivo and no overt side-effects were observed. Conclusion Iguratimod ameliorates immune nephritis in MRL/lpr mice via a non-antiproliferative mechanism. Our data suggest a potential therapeutic role of iguratimod in lupus.
A Graphical Representation for Identifier Structure in Logs

Application console logs are a ubiquitous tool for diagnosing system failures and anomalies. While several techniques exist to interpret logs, describing and assessing log quality remains relatively unexplored. In this paper, we describe an abstract graphical representation of console logs called the identifier graph and a visualization based on this representation. Our representation breaks logs into message types and identifier fields and shows the interrelation between the two. We describe two applications of this visualization. We apply it to Hadoop logs from two different deployments, showing that we capture important properties of Hadoop's logging as well as relevant differences between the two sites. We also apply our technique to logs from two other systems under development. We show that our representation helps highlight flaws in the underlying application logging.
Simulation of Contrast Agent Transport in Arteries with Multilayer Arterial Wall: Impact of Arterial Transmural Transport on the Bolus Delay and Dispersion

One assumption of DSC-MRI is that the injected contrast agent is kept totally intravascular and the arterial wall is impermeable to contrast agent. The assumption is unreal for such small contrast agent as Gd-DTPA can leak into the arterial wall. To investigate whether the unreal assumption is valid for the estimation of the delay and dispersion of the contrast agent bolus, we simulated flow and Gd-DTPA transport in a model with multilayer arterial wall and analyzed the bolus delay and dispersion qualified by mean vascular transit time (MVTT) and the variance of the vascular transport function. Factors that may affect Gd-DTPA transport hence the delay and dispersion were further investigated, such as integrity of endothelium and disturbed flow. The results revealed that arterial transmural transport would slightly affect MVTT and moderately increase the variance. In addition, although the integrity of endothelium can significantly affect the accumulation of contrast agent in the arterial wall, it had small effects on the bolus delay and dispersion. However, the disturbed flow would significantly increase both MVTT and the variance. In conclusion, arterial transmural transport may have a small effect on the bolus delay and dispersion when compared to the flow pattern in the artery.
Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

The clinical evaluation of neural transplantation as a potential treatment for Huntington's disease (HD) was initiated in an attempt to replace lost neurons and improve patient outcomes. Two of 3 patients with HD reported here, who underwent neural transplantation containing striatal anlagen in the striatum a decade earlier, have demonstrated marginal and transient clinical benefits. Their brains were evaluated immunohistochemically and with electron microscopy for markers of projection neurons and interneurons, inflammatory cells, abnormal huntingtin protein, and host-derived connectivity. Surviving grafts were identified bilaterally in 2 of the subjects and displayed classic striatal projection neurons and interneurons. Genetic markers of HD were not expressed within the graft. Here we report in patients with HD that (i) graft survival is attenuated long-term; (ii) grafts undergo disease-like neuronal degeneration with a preferential loss of projection neurons in comparison to interneurons; (iii) immunologically unrelated cells degenerate more rapidly than the patient's neurons, particularly the projection neuron subtype; (iv) graft survival is attenuated in the caudate in comparison to the putamen in HD; (v) glutamatergic cortical neurons project to transplanted striatal neurons; and (vi) microglial inflammatory changes in the grafts specifically target the neuronal components of the grafts. These results, when combined, raise uncertainty about this potential therapeutic approach for the treatment of HD. However, these observations provide new opportunities to investigate the underlying mechanisms involved in HD, as well as to explore additional therapeutic paradigms.
Freeway patterns for SOA systems

Business processes typically contain multiple process steps. In a service oriented landscape, these process steps are realized as services. An implementation of a business process is hence composed of multiple service invocations. In a service oriented landscape, a process model doesn't exist in isolation; it is supplemented by other paradigms which allow the process model to be executed. This paper presents all of these as patterns, and describes how these can be tied together to create a dynamic service oriented landscape. The patterns that this paper describes are: - Service orchestration -- the modeling of a business process as a set of process steps - Service registry -- a mapping of process steps to service endpoints - Service monitor -- a mechanism to monitor the health of an endpoint
Optimists Have More Fun , But Do They Learn Better ? – On the Influence of Emotional and Social Factors on Learning CS and Math

Learning to program is notoriously difficult. In order to understand predictors of success and, when possible, improve the course design of the introductory pprogramming course to increase the likelyhood of success, we study a number of factors that potentially indicate programming aptitude. We have studied the influence of emotional and social factors on students’ learning outcome. Emotional health and social well-being has been measured in terms of five variables: perfectionism, selfesteem, coping tactics, affective states, and optimism. No correlation was found! Others have found the variables perfectionism, selfesteem, and affective states to be predictors of success. We identify potential explanations for this seeming contradiction.
Dramatization Meets Narrative Presentations

In recent times, information presentation has evolved towards sophisticated approaches that involve multi-modal aspects and character-based mediation. This paper presents a novel methodology for creating information presentations based on a dramatization of the content exposition in two respects. On one side, the author plots a character's monologue that aims at achieving presentation goal and exhibits an engaging inner conflict; on the other side, the system architecture dynamically assembles the elementary units of the plot scripted by the author by implementing a tension between contrasting communicative functions. The methodology has been applied in the implementation of a virtual guide to an historical site.
"I own my T!" : the experience of older transgender people of color regarding personal identity, systems of support, and desires for the future

While it has been widely reported that transgender individuals experience mistreatment in all aspects of life, transgender people of color, who have rarely been the focus of studies, are faced with even higher incidents of bias (Auldridge, et al., 2012; Dunn & Moodie-Mills, 2012; Grant, et al., 2011). Especially absent is writing on older transgender people of color (Auldridge, et al., 2012; Cook-Daniels, 2015; Fredricksen-Goldsen, et al., 2013; Persson, 2009; Van Wagenen, Driskell & Bradford, 2013). Also missing is literature on the resiliency of transgender people of color and transgender elders. Finally, of the few studies that do exist, most focus on the negatives and on the life-threatening aspects of trans people’s lives. With that in mind, the purpose of this qualitative study was to look at the highly understudied population of older transgender people of color in order to begin to understand their experiences related to personal identity, to systems of support, and to their goals and desires for the future. The goal of the study was to expand the context for social workers – especially those that specialize in gerontology and related policy makers -to consider the challenges, desires, and goals faced by this growing population of aging transgender people of color. Through nine semi-structured interviews, a narrative of lifelong oppression and injustice is exposed in all aspects of living for this sample. Findings indicate an early understanding of gender difference and confusion related to a poverty of language and lack of safety to speak about this difference. Despite lifelong complexity of gender and the intersection of racial/ethnic disparity, however, participants appear to have uncovered a capacity for coping with multiple marginalization through support of family (chosen or blood), community, and spirituality. Finally, sample members give great consideration to legacy but view that dynamic through a non-traditional lens, sharing a strong desire to give to younger generations through varied expressions of social justice work -a positive legacy of social change for those who follow in their footsteps. "I OWN MY T! " THE EXPERIENCE OF OLDER TRANSGENDER PEOPLE OF COLOR REGARDING PERSONAL IDENTITY, SYSTEMS OF SUPPORT, AND DESIRES FOR THE FUTURE A project based upon an independent investigation, submitted in partial fulfillment of the requirements for the degree of Master of Social Work.
Circumstellar Dust Disks in Taurus-Auriga: The Submillimeter Perspective

We present a sensitive, multiwavelength submillimeter continuum survey of 153 young stellar objects in the Taurus-Auriga star formation region. The submillimeter detection rate is 61% to a completeness limit of ~10 mJy (3 σ) at 850 μm. The inferred circumstellar disk masses are lognormally distributed with a mean mass of ~5 × 10-3 M☉ and a large dispersion (0.5 dex). Roughly one-third of the submillimeter sources have disk masses larger than the minimal nebula from which the solar system formed. The median disk-to-star mass ratio is 0.5%. The empirical behavior of the submillimeter continuum is best described as Fν ∝ ν2. 0±0.5 between 350 μm and 1.3 mm, which we argue is due to the combined effects of the fraction of optically thick emission and a flatter frequency behavior of the opacity compared to the interstellar medium. The latter effect could be due to a substantial population of large dust grains, which presumably would have grown through collisional agglomeration. In this sample, the only stellar property that is correlated with the outer disk is the presence of a companion. We find evidence for significant decreases in submillimeter flux densities, disk masses, and submillimeter continuum slopes along the canonical infrared spectral energy distribution evolution sequence for young stellar objects. The fraction of objects detected in the submillimeter is essentially identical to the fraction with excess near-infrared emission, suggesting that dust in the inner and outer disks is removed nearly simultaneously.
Superhydrophobic silica wool—a facile route to separating oil and hydrophobic solvents from water

Abstract Silica microfiber wool was systematically functionalized in order to provide an extremely water repellent and oleophilic material. This was carried out using a two-step functionalization that was shown to be a highly effective method for generating an intense water repulsion and attraction for oil. A demonstration of the silica wools application is shown through the highly efficient separation of oils and hydrophobic solvents from water. Water is confined to the extremities of the material, while oil is absorbed into the voids within the wool. The effect of surface functionalization is monitored though observing the interaction of the material with both oils and water, in addition to scanning electron microscope images, x-ray photoelectron spectroscopy and energy dispersive x-ray analysis. The material can be readily utilized in many applications, including the cleaning of oil spills and filtering during industrial processes, as well as further water purification tasks—while not suffering the losses of efficiency observed in current leading polymeric materials.
Representing Motion in a Static Image: Constraints and Parallels in Art, Science, and Popular Culture

Representing motion in a picture is a challenge to artists, scientists, and all other imagemakers. Moreover, it presents a problem that will not go away with electronic and digital media, because often the pedagogical purpose of the representation of motion is more important than the motion itself. All satisfactory solutions evoke motion—for example, dynamic balance (or broken symmetry), stroboscopic sequences, affine shear (or forward lean), and photographic blur—but they also typically sacrifice the accuracy of the motion represented, a solution often unsuitable for science. Vector representations superimposed on static images allow for accuracy, but are not applicable to all situations. Workable solutions are almost certainly case specific and subject to continual evolution through exploration by imagemakers.
The Application of Data Mining Technology for Intelligent Enterprise Resource Planning System

In a method for regulating the foam density in products foamed from liquid and a gas additive the density of the foam and the excess pressure are simultaneously measured in the conveyor line of the foam, correlated in an evaluation circuit and the free foam density, that is, the density of the released foam under atmospheric pressure, is calculated therefrom. This calculated value is compared with a set value of the free foam density and in the case of deviations the ratio of the amounts of liquid and gas conveyed is varied. This method makes it possible for the relative fluctuation in density of the released foam to be reduced to values on the order of 1%.
Multiple Yeast Genes, Including Paf1 Complex Genes, Affect Telomere Length via Telomerase RNA Abundance

ABSTRACT Twofold reductions in telomerase RNA levels cause telomere shortening in both humans and the yeast Saccharomyces cerevisiae. To test whether multiple genes that affect telomere length act by modulating telomerase RNA abundance, we used real-time reverse transcription-PCR to screen S. cerevisiae deletion strains reported to maintain shorter or longer telomeres to determine the levels of their telomerase RNA (TLC1) abundance. Of 290 strains screened, 5 had increased TLC1 levels; 4 of these maintained longer telomeres. Twenty strains had decreased TLC1 levels; 18 of these are known to maintain shorter telomeres. Four strains with decreased TLC1 RNA levels contained deletions of subunits of Paf1C (polymerase II-associated factor complex). While Paf1C had been implicated in the transcription of both polyadenylated and nonpolyadenylated RNAs, Paf1C had not been associated previously with the noncoding telomerase RNA. In Paf1C mutant strains, TLC1 overexpression partially rescues telomere length and cell growth defects, suggesting that telomerase RNA is a critical direct or indirect Paf1C target. Other factors newly identified as affecting TLC1 RNA levels include cyclin-dependent kinase, the mediator complex, protein phosphatase 2A, and ribosomal proteins L13B and S16A. This report establishes that a subset of telomere length genes act by modulating telomerase RNA abundance.
Improving psychosocial well-being of child laborers and young people who are engaged in low-income economic activities in Istanbul, Turkey

ABSTRACT Child laborers are typically subjected to multiple and chronic traumatic experiences. With no parents or caregivers to act as a buffer zone against stressors, they grow up in chaotic and unpredictable work environments. Child laborers are more at risk of developing a range of psychological, emotional, and behavioral problems. The authors established an 8-month psychosocial support program for child laborers and young people attending a vocational training center one day a week. The authors found that anxiety and depression moderately correlated with negative self-concept, somatization, and hostility. Toward the end of the 8-month program, participants reported improved psychological and emotional well-being. The provision of a safe and mediated psychosocial program enhanced the emotional and mental well-being of vulnerable children and young people.
Quantum Field Theory of the Pinned Density Wave

A model is discussed in which an electric field induces quantum nucleation of soliton-antisoliton pairs in a pinned charge or spin density wave. Coulomb blockade prevents pair creation until the electric field exceeds a sharp threshold value, which can be much smaller than the classical depinning field. We calculate the vacuum state energy and expectation value of the phase �, which is treated as a quantum scalar field. We find that the phase can also be much smaller, below threshold, than predicted by classical “sliding” density wave models.
Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis

Purpose The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. Materials and Methods Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databases up to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. Results A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphism was associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61–0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. Conclusion The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
AFFECT OF ESQ TRAINING (TRAINING OF EMOTIONAL INTELLIGENCE AND SPIRITUAL INTELLIGENCE) TO ORGANIZATIONAL COMMITMENT AND JOB SATISFACTION

Spirituality is considered one of the key success factors of the organization in the long term. Organizations today are looking for ways to succeed by using all its potential to maximize commitment, job satisfaction and internal motivation of employees through various domains of spirituality. Emotional intelligence also affects the performance of the company. The purpose of this study are: 1) to analyze the effects of spiritual intelligence on organizational commitment (KO) and job satisfaction (KK), 2) to analyze the effects of emotional intelligence on organizational commitment (KO) and job satisfaction (KK). This research method is using a survey with 244 people in random and involves in-depth interviews to the management of the company. The analysis tool used is descriptive analysis and structural equation model (SEM). The results of this study indicate that spiritual intelligence (SI) and emotional intelligence (EI) affects to organizational commitment (KO) and job satisfaction (KK) directly.
Survival and Clonal Expansion of Mutating “Forbidden” (Immunoglobulin Receptor–Deficient) Epstein-Barr Virus–Infected B Cells in Angioimmunoblastic T Cell Lymphoma

Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a peculiar T cell lymphoma, as expanding B cell clones are often present besides the malignant T cell clones. In addition, large numbers of Epstein-Barr virus (EBV)-infected B cells are frequently observed. To analyze the differentiation status and clonal composition of EBV-harboring B cells in AILD, single EBV-infected cells were micromanipulated from lymph nodes of six patients with frequent EBV+ cells and their rearranged immunoglobulin (Ig) genes analyzed. Most EBV-infected B cells carried mutated Ig genes, indicating that in AILD, EBV preferentially resides in memory and/or germinal center B cells. EBV+ B cell clones observed in all six cases ranged from small polyclonal to large monoclonal expansions and often showed ongoing somatic hypermutation while EBV− B cells showed little tendency for clonal expansion. Surprisingly, many members of expanding B cell clones had acquired destructive mutations in originally functional V gene rearrangements and showed an unfavorable high load of replacement mutations in the framework regions, indicating that they accumulated mutations over repeated rounds of mutation and division while not being selected through their antigen receptor. This sustained selection-free accumulation of somatic mutations is unique to AILD. Moreover, the survival and clonal expansion of “forbidden” (i.e., Ig-deficient) B cells has not been observed before in vivo and thus represents a novel type of viral latency in the B cell compartment. It is likely the interplay between the microenvironment in AILD lymph nodes and the viral transformation that leads to the survival and clonal expansion of Ig-less B cells.
A Probabilistic Clustering-Based Indoor Location Determination System

We present an indoor location determination system based on signal strength probability distributions for ta ckling the noisy wireless channel and clustering to reduce computation requirements. We provide two implementation techniques, namely, Joint Clustering and Incremental Triangulation and describe their tradeoffs in terms of location deter mination accuracy and computation requirement. Both techniques have been incorporated in two implemented context-aware systems: User Positioning System and the Rover System, both running on Compaq iPAQ Pocket PC’s with Familiar distribution of Linux for PDA’s. The results obtained show that both tech niques give the user location with over 90% accuracy to within 7 feet with very low computation requirements, hence enabling a set of context-aware applications.