Miracle-dz/UniFAR-FTUs huggingface dataset:
Coping motives for drinking affect stress reactivity but not alcohol consumption in a clinical laboratory setting.

OBJECTIVE Stress evokes thoughts about alcohol and enhances alcohol's rewarding value in drinkers who use alcohol to cope with negative affect. The present study extends prior research by examining whether this effect applies to actual alcohol consumption following a stressor and whether individuals with high and low coping motives for drinking differ in stress reactivity. METHOD Nondependent drinkers with high scores (﹥1 SD above national norms) on the coping motives subscale on the Drinking Motives Questionnaire (n = 41; 46% women) were enrolled along with age- and gender-matched nondependent drinkers with low coping motives (n = 41). Participants were randomized to receive the Trier Social Stress Test or a no-stress control condition. Following the stress manipulation, participants could consume up to 473 ml of beer in a "taste test," a covert measure of alcohol consumption. Stress reactivity was measured with both objective and subjective indices, and milliliters of beer consumed was the alcohol-relevant outcome. RESULTS Participants with high coping motives showed a less robust stress response to the Trier Social Stress Test than participants with low coping motives for drinking. However, the stressor did not result in greater consumption of alcohol (i.e., no main effect of stress induction) or differential drinking in the two motive groups (i.e., no Stressor × Coping Motive group interaction). CONCLUSIONS Findings suggest that nondependent drinkers with and without coping motives for drinking may experience a stress provocation differently, but exposure to a standardized social stressor does not lead to differential drinking in these groups in a clinical laboratory setting.
Development of a Brazilian Portuguese Version of the Oswestry Disability Index: Cross-Cultural Adaptation, Reliability, and Validity

Study Design. Translation, revision, back-translation, and 3-way validity were performed. Objective. The objective of this study was to translate a version of the Oswestry Disability Index (ODI) into Brazilian Portuguese and evaluate its reliability. Summary of Background Data. Reports in the literature have identified a need for internationally standardized and reliable measurements to analyze back pain. The ODI has become one of the principal outcome measurements used in the management of spinal disorders. Methods. The cross-cultural adaptation was performed according to the internationally recommended methodology, using the following guidelines: translation, back-translation; revision by a committee, and pretesting. The psychometric properties were evaluated by administering the questionnaire to 120 subjects with back pain. Reliability was estimated through stability and homogeneity assessment. The validity was tested comparing ODI scores with the following measurements: Roland-Morris Disability Questionnaire, SF-36, and a Numerical Pain Scale. Results. Good internal consistency was found (Cronbach’s alpha = 0.87). Intraclass correlation coefficient for test-retest reliability was 0.99. The ODI showed moderate correlation with pain measurement (r = 0.66). Relatively high correlation was also found between the ODI and the Roland-Morris scores (r = 0.81). There was significant correlation (P < 0.001) between ODI scores and the 8 scales of the SF-36. Conclusions. The data showed that the cultural adaptation process was successful and that the adapted instrument demonstrated having excellent psychometric properties, reliable in the Brazilian culture.
Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate

Background Patients with rheumatoid arthritis (RA) who take methotrexate (MTX) are advised to limit their alcohol intake due to potential combined hepatotoxicity. However, data are limited to support this. The aim of this study was to quantify the risk of developing abnormal liver blood tests at different levels of alcohol consumption, using routinely collected data from primary care. Methods Patients with RA in the Clinical Practice Research Datalink starting MTX between 1987 and 2016 were included. Hepatotoxicity was defined as transaminitis: alanine transaminase or aspartate aminotransferase more than three times the upper limit of normal. Crude rates of transaminitis were calculated per 1000 person-years, categorised by weekly alcohol consumption in units. Cox proportional hazard models tested the association between alcohol consumption and transaminitis univariately, then age and gender adjusted. Results 11 839 patients were included, with 530 episodes of transaminitis occurring in 47 090 person-years follow-up. Increased weekly alcohol consumption as a continuous variable was associated with increased risk of transaminitis, adjusted HR (95% CI) per unit consumed 1.01 (1.00 to 1.02); consuming between 15 and 21 units was associated with a possible increased risk of hepatotoxicity, while drinking >21 units per week significantly increased rates of transaminitis, adjusted HR (95% CI) 1.85 (1.17 to 2.93). Conclusions Weekly alcohol consumption of <14 units per week does not appear to be associated with an increased risk of transaminitis.
t-3-Pentyl-r-2,c-6-diphenylpiperidin-4-one

In the title molecule, C22H27NO, the piperidine ring adopts a chair conformation, with all substituents equatorial. The dihedral angle between the two phenyl rings is 56.90 (5)°. In the crystal, molecules are linked by weak C—H⋯O hydrogen bonds. A C—H⋯π interaction involving the phenyl ring at the 6-position is also found in the crystal structure.
Industrialization, Convergence, and Patterns of Growth

The long-run behavior of national growth rates has long been of great interest because it sheds light on future income disparities across countries as well as the prospective income of individual countries. Recently, the interest has been further stimulated, for the neoclassical growth model [6; 31] and new endogenous growth models [16; 26] yield sharply different predictions: while the neoclassical growth model predicts that countries with similar preferences and technology will converge to similar levels of per capita income, endogenous growth models predict that there will be no such tendency. In this regard, a substantial body of empirical study has examined whether the regression of the growth rate on the level of income per capita indeed produces a negative coefficient as predicted by the neoclassical model. Evidence is mixed, however. In particular, the regression results are very sensitive to the selection of countries: typically, the results for relatively developed countries are consistent with the convergence hypothesis [3; 11], but the results for the samples including less developed countries are rather in conflict with the convergence argument [9; 27]. The goals of this paper are (1) to document a stylized nonlinear (humped) pattern in growth, (2) to demonstrate how an explicit recognition of this pattern helps reconcile the conflicting results on convergence (and the conditional convergence result, below), and (3) to suggest a potential explanation for the humped pattern from a view of industrialization. Section II shows that there exists an economically and statistically significant hump in the growth rate of postwar cross-country data: on average, middle income countries grew the fastest, high income countries the next, and low income countries the slowest. Thus, a negative correlation between growth rates and income per capita is observed when low income countries are excluded from the sample, but no such correlation is found for a larger class of countries. To find the factors that can explain the fast growth of middle income countries, this paper first considers the most widely used three explanatory variables in growth regressions: the investment to GDP ratio, the percentage of age group enrolled in secondary education, and the rate of population growth. Both parametric and nonparametric analyses show that these variables cannot explain the humped pattern: middle income countries grew far faster than could be explained by
A Potent HER3 Monoclonal Antibody That Blocks Both Ligand-Dependent and -Independent Activities: Differential Impacts of PTEN Status on Tumor Response

HER3/ERBB3 is a kinase-deficient member of the EGFR family receptor tyrosine kinases (RTK) that is broadly expressed and activated in human cancers. HER3 is a compelling cancer target due to its important role in activation of the oncogenic PI3K/AKT pathway. It has also been demonstrated to confer tumor resistance to a variety of cancer therapies, especially targeted drugs against EGFR and HER2. HER3 can be activated by its ligand (heregulin/HRG), which induces HER3 heterodimerization with EGFR, HER2, or other RTKs. Alternatively, HER3 can be activated in a ligand-independent manner through heterodimerization with HER2 in HER2-amplified cells. We developed a fully human mAb against HER3 (KTN3379) that efficiently suppressed HER3 activity in both ligand-dependent and independent settings. Correspondingly, KTN3379 inhibited tumor growth in divergent tumor models driven by either ligand-dependent or independent mechanisms in vitro and in vivo. Most intriguingly, while investigating the mechanistic underpinnings of tumor response to KTN3379, we discovered an interesting dichotomy in that PTEN loss, a frequently occurring oncogenic lesion in a broad range of cancer types, substantially blunted the tumor response in HER2-amplified cancer, but not in the ligand-driven cancer. To our knowledge, this represents the first study ascertaining the impact of PTEN loss on the antitumor efficacy of a HER3 mAb. KTN3379 is currently undergoing a phase Ib clinical trial in patients with advanced solid tumors. Our current study may help us optimize patient selection schemes for KTN3379 to maximize its clinical benefits. Mol Cancer Ther; 15(4); 689–701. ©2016 AACR.
Scalable softmax loss for face verification

Thanks to the recent development of deep convolutional neural networks, the performance of face verification has increased significantly. The softmax loss function is used mostly to make CNN models trained well. In order to get more robust face feature by deep CNN model, this paper proposes a new supervision signal based on the regular softmax loss function, namely scalable softmax loss, for face verification task. The scalable softmax loss function adjust the contribution to final loss for different training samples by a learned parameter. And, it's important to note that our proposed scalable softmax loss function can be easily implemented using existing deep learning frameworks. Extensive analysis and experiments on Labeled Face in the Wild(LFW) and YouTube Faces(YTF) show the superiority of the scalable softmax loss function in face verification task. Specially, our proposed scalable achieves comparable results on challenging LFW data set and YTF data set with the accuracy 99% and 95.08% respectively. Codes are released at1.
Antibodies against malaria and Epstein‐Barr virus in childhood Burkitt lymphoma: A case‐control study in Uganda

Burkitt lymphoma, a childhood tumor common in parts of sub‐Saharan Africa, has been directly associated with Epstein‐Barr virus (EBV) and indirectly with prevalence of malaria. We studied antibodies to both EBV and malaria in children diagnosed with this cancer in Uganda. We performed a case‐control study of HIV‐seronegative children (≤15 years) admitted to hospital. Cases were diagnosed with Burkitt lymphoma and controls with non‐malignant conditions or non‐lymphatic cancers. Interviews were conducted and serological samples collected and, when possible, tested for both EBV and malaria. Adjusted odds ratios (ORs) for Burkitt lymphoma were estimated using unconditional logistic regression adjusting for sex, age, residential district, household income and tribe. The mean age of cases was 7 years and 61% were male. Compared to controls, cases were more likely to be reported having received more frequent treatment for malaria in the past year (OR = 2.0; p = 0.001) and less likely to be living in a home where insecticides were used (OR = 0.2; p < 0.0001). Odds ratios for Burkitt lymphoma in children increased with increasing antibody levels against EBV (p < 0.0001) and malaria (p = 0.05). Findings were similar for children residing in districts close to the capital city and in remote areas. Cases were 5 times more likely than controls to have raised levels of both EBV and malaria antibodies (OR = 5.0; p = 0.003). Our findings suggest that EBV and malaria may act synergistically in the pathogenesis of childhood Burkitt lymphoma. Malaria prevention measures may also prevent this childhood cancer. © 2007 Wiley‐Liss, Inc.
Serum Fetuin-A Concentration and Endothelial Dysfunction in Chronic Kidney Disease

Background: Defective endothelial function, an initial step in the development of atherosclerotic plaque, is prevalent in moderate to advanced chronic kidney disease (CKD). In this study, the investigators hypothesized that fetuin-A, a calcification inhibitor, is a novel risk factor for the development of endothelial dysfunction in patients. Methods: 198 nondiabetic patients with a mean age of 44.0 ± 12.4 years and with different stages of CKD were studied. In addition to a detailed metabolic panel, flow-mediated dilatation assessed by high-resolution brachial ultrasonography was performed to determine endothelial dysfunction. Carotid intima-media thickness was also estimated by ultrasonography. Serum fetuin-A concentrations were determined by using a human ELISA method. Results: Endothelial dysfunction was observed in all stages (1–5) of CKD and worsened in parallel to the reduction in estimated glomerular filtration rate. Serum fetuin-A concentrations were also found to be decreased in all but stage 1 CKD. On multiple regression analysis, endothelial dysfunction was independently associated with fetuin-A (β = 0.745, p < 0.001) and intact parathyroid hormone concentrations (β = –0.216, p < 0.001). Conclusion: These data in a selected cohort of CKD patients indicate that fetuin-A may be one of the contributing factors for the development of endothelial dysfunction in CKD patients.
Isometric Squeeze Relaxation (Progressive Relaxation) Vs Meditation: Absorption and Focusing as Predictors of State Effects

We taught isometric squeeze relaxation (a variant of progressive relaxation) or meditation to 52 anxious subjects (16 men, 36 women). For meditation, pretreatment high absorption correlated with reductions in state cognitive and somatic anxiety as well as increments in state focusing. For isometric squeeze relaxation, pretreatment low state focusing correlated with reductions in somatic anxiety and increments in focusing. Results suggest that isometric squeeze relaxation (and progressive relaxation) may be more appropriate for individuals who have difficulty focusing, and meditation for those who already possess well-developed relaxation skills at a trait level. The results appear more consistent with Smith's cognitive-behavioral model of relaxation than with Benson's relaxation response or Davidson and Schwartz's specific effects models.
Charged residues at protein interaction interfaces: Unexpected conservation and orchestrated divergence

Protein–protein interactions play an essential role in the functioning of cell. The importance of charged residues and their diverse role in protein–protein interactions have been well studied using experimental and computational methods. Often, charged residues located in protein interaction interfaces are conserved across the families of homologous proteins and protein complexes. However, on a large scale, it has been recently shown that charged residues are significantly less conserved than other residue types in protein interaction interfaces. The goal of this work is to understand the role of charged residues in the protein interaction interfaces through their conservation patterns. Here, we propose a simple approach where the structural conservation of the charged residue pairs is analyzed among the pairs of homologous binary complexes. Specifically, we determine a large set of homologous interactions using an interaction interface similarity measure and catalog the basic types of conservation patterns among the charged residue pairs. We find an unexpected conservation pattern, which we call the correlated reappearance, occurring among the pairs of homologous interfaces more frequently than the fully conserved pairs of charged residues. Furthermore, the analysis of the conservation patterns across different superkingdoms as well as structural classes of proteins has revealed that the correlated reappearance of charged residues is by far the most prevalent conservation pattern, often occurring more frequently than the unconserved charged residues. We discuss a possible role that the new conservation pattern may play in the long‐range electrostatic steering effect.
An Integrative Review of Biological Variants and Chronic Stress in Emerging Adults With Chronic Conditions

PURPOSE The purpose of this integrative review was to evaluate and synthesize studies that incorporated biological measures and examined their associations with chronic stress and anxiety in adolescents and emerging adults with chronic health conditions. DESIGN An integrative literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement to identify studies published between 2005 and 2015. METHODS Using key terms, three databases (PubMed/Medline, PsycInfo and the Cumulative Index to Nursing and Allied Health Literature) were searched by a research librarian. Additional publications with relevance to the topic were identified from citing and cited literature. The full text of 61 publications was reviewed. The final group of articles analyzed for this review included 36 peer-reviewed publications and meeting abstracts. FINDINGS Studies varied considerably in characteristics, theoretical frameworks, phenotypes of interest, and study measures. Few studies evaluated genomic variants; those that did often examined small samples and a limited number of biological factors. CONCLUSIONS Studies of chronic stress and anxiety in adolescents and emerging adults with chronic health conditions are currently limited in scope and impact. A more comprehensive approach will facilitate translation into practice to improve short- and long-term health outcomes. CLINICAL RELEVANCE Precision and genomic healthcare initiatives support the relevance of this work for nurses in all areas of clinical practice. Genomic testing is expanding to include individuals in all age groups, with and without diagnosed conditions. As psychological and behavioral phenotypes may influence self-management outcomes of adolescents and emerging adults with chronic health conditions, further research in this area is warranted.
3D anatomical reconstruction of human cardiac conduction system and simulation of bundle branch block after TAVI procedure

The cardiac conduction system (CCS) is responsible for the initiation and propagation of action potentials through the heart ensuring efficient pumping of blood. Understanding the anatomy of the CCS and its relationship with other major cardiac components is important to help understand arrhythmias and how certain procedures may increase the incidence of arrhythmias developing. We sectioned a whole human heart and performed Masson's trichrome histology in order to identify the components of the CCS. The histology images were used to construct a 3D anatomical model. We have shown that it is possible to create a 3D anatomical model of the human heart incorporating the CCS based on histological images, and that this model can be used to perform computer simulations of cardiac excitation. From the reconstruction we have been able to show the relative positions of the CCS components to each other. We have also shown how the close proximity of the CCS to the aortic valve can explain some of the conduction complications, such as left bundle branch block, that arise after aortic valve replacement procedures.
Uncertainty, Hiring and Subsequent Performance: The NFL Draft

In this article, we analyze the impact of uncertainty on the hiring process. We show the connection between models of statistical discrimination where uncertainty can work against groups that have less reliable indicators of future productivity and models of option value where uncertainty about future productivity can be beneficial for these groups. These models generate hypotheses about the relationship between ex ante hiring patterns and ex post productivity. This is applied to the market for NFL football players. We provide various estimates of NFL success, which suggest that statistical discrimination and option value influence choices in this market.
Whole body vibration (WBV) following spinal cord injury (SCI) in rats: Timing of intervention.

BACKGROUND Following spinal cord injury (SCI), exercise training provides a wide range of benefits and promotes activity-dependent synaptic plasticity. Whole body vibration (WBV) in SCI patients improves walking and spasticity as well as bone and muscle mass. However, little is known about the effects of timing or frequency of intervention. OBJECTIVE To determine which WBV-onset improves locomotor and bladder functions and influences synaptic plasticity beneficially. METHODS SCI was followed by WBV starting 1, 7, 14, 28 days after injury (WBV1, WBV7, etc.) and continued for 12 weeks. Intact animals and those receiving SCI but no WBV (No WBV), SCI plus WBV twice daily (2×WBV) and SCI followed by passive hindlimb flexion-extension (PFE) served as controls. Locomotor [BBB rating, foot stepping angle (FSA) and rump-height index (RHI)] as well as bladder function were determined at 1, 3, 6, 9, and 12 weeks. Following perfusion fixation at 12 weeks, lesion volume and immunofluorescence for astrogliosis (GFAP), microglia (IBA1) and synaptic vesicles (synaptophysin, SYN) were determined. RESULTS Compared to the No WBV group, the WB7 and WBV14 groups showed significantly faster speeds of BBB score recovery though this effect was temporary. Considering RHI we detected a sustained improvement in the WBV14 and PFE groups. Bladder function was better in the WBV14, WBV28, 2×WBV and PFE groups. Synaptophysin levels improved in response to WBV7 and WBV14, but worsened after WBV28 in parallel to an increased IBA1 expression. Correlation- and principal components analysis revealed complex relationships between behavioural (BBB, FSA, RHI) and morphological (GFAP, IBA1, SYN) measurements. CONCLUSIONS WBV started 14 days after SCI provides the most benefit (RHI, bladder); starting at 1day after SCI provides no benefit and starting at 28 days may be detrimental. Increasing the intensity of WBV to twice daily did not provide additional benefit.