Miracle-dz/UniFAR-FTUs huggingface dataset:
Initiation of axillary and floral meristems in Arabidopsis.

Shoot development is reiterative: shoot apical meristems (SAMs) give rise to branches made of repeating leaf and stem units with new SAMs in turn formed in the axils of the leaves. Thus, new axes of growth are established on preexisting axes. Here we describe the formation of axillary meristems and floral meristems in Arabidopsis by monitoring the expression of the SHOOT MERISTEMLESS and AINTEGUMENTA genes. Expression of these genes is associated with SAMs and organ primordia, respectively. Four stages of axillary meristem development and previously undefined substages of floral meristem development are described. We find parallels between the development of axillary meristems and the development of floral meristems. Although Arabidopsis flowers develop in the apparent absence of a subtending leaf, the expression patterns of AINTEGUMENTA and SHOOT MERISTEMLESS RNAs during flower development suggest the presence of a highly reduced, "cryptic" leaf subtending the flower in Arabidopsis. We hypothesize that the STM-negative region that develops on the flanks of the inflorescence meristem is a bract primordium and that the floral meristem proper develops in the "axil" of this bract primordium. The bract primordium, although initially specified, becomes repressed in its growth.
Use of enhanced green fluorescent protein to monitor retroviral‐mediated gene therapy in human keratinocytes

Abstract: Keratinocytes have great promise as targets for gene therapy involving both skin as well as for systemic disorders due to their availability and potential long life span. Improvement of gene transfer into keratinocytes will be greatly facilitated by markers that will allow both rapid detection and efficient selection of transduced cells. For these purposes, a recombinant version of the Aequorea victoria green fluorescent protein that is enhanced for high‐level expression in mammalian cells (EGFP) was placed into a replication‐deficient retroviral vector. High‐titer retrovirus was used to transduce both primary cultures of neonatal foreskin‐derived human keratinocytes (HK) as well as the immortalized keratinocyte‐derived cell line HaCaT. Both cell types stably expressed the EGFP, and this marker allowed rapid purification of transduced cells by fluorescence‐activated cell sorting. EGFP expression was seen in HaCaT keratinocytes for at least 40 passages, and the presence of this construct did not effect cell growth, or apoptosis in response to UVB or etoposide. Transduced populations of HK were grafted into SCID mice, resulting in a functional epidermis. EGFP expression was readily seen in vivo by exposing the xenografts to an ultraviolet light source. These studies demonstrate the feasibility of using EGFP as a convenient and rapid marker to monitor keratinocyte gene transfer both in vitro and in vivo.
Interractive Control Systems and Strategic Orientation on Competitive Position of Sugar Firms in Western Kenya

Despite strategic management advocating for the use of strategic control practices to improve the implementation of strategic plans and competitive position, establishing the strategic control-performance relationship has been problematic, suggesting failure by researchers to consider contingent variables. This study used data, collected during the period November 2008 to May 2009 from 109 senior managers in a census survey of 45 firms in the sugar value-chain in western Kenya, to examine the moderating effect of strategic orientation on the relationship between belief control and competitive position. Descriptive statistics, bi-variate regression analysis and moderated regression analysis were used to analyze data. The findings revealed moderate prevalence of Interactive control mean 2.86, std dev 0.83. The most prevalent strategic orientation was the reactor (60%), followed by defender (24%); prospectors (9%) and analyzers (7%). All the four levers were positively and significantly related to competitive position (interactive β = 0.393, p < 0.01). The results of this study suggest that urgent measures are required by the firms in the study to design interractive control systems to cope with the changing business environment. The study contributes to validation and upgrade of the existing belief control theory. For managers, the study sheds light on the design and use of belief controls and also for public sector managers in guiding the strategic change. It is recommended that future studies focus on the specific firms in sugar value chain and adopt longitudinal casestudy designs to establish causal relationships among variables.
The Relationship between Dividend Policy and Shareholder’s Wealth (A Case Study At Mining Companies in Indonesia)

This research is about the relationship between dividend policy and shareholder’s wealth from 37 mining companies listed in Indonesia Stock Exchange (IDX) from 2011 to 2013. Independent variable which is used in this research are dividend policy and profitability. Dividend policy is measured as dividend per share (DPS) and profitability is measured as Return On Equity (ROE). Dependent variable which is used in this research is shareholder’s wealth. Shareholders’ wealth is measured as Market Price Per Share (MPPS). Investment opportunity which is measured as fixed asset growth, is used as moderating variable which can strengthen the relationship between independent and dependent variable. The result of this research proves that dividend policy has significant influence to shareholder’s wealth, while investment opportunity, as a moderating variable, is proven to strengthen the relationship between dividend policy and shareholder’s wealth.
Design of a super-high speed permanent magnet synchronous motor for cryogenic applications

This paper gives the design and simulation of a permanent magnet synchronous motor (PMSM) for a super-high speed centrifugal compressor drive application. The PMSM has an output power of 2000 W at 200,000 rpm with 28 V dc power supply. It is designed for operation at a cryogenic temperature of 77 K. The designed PMSM is a 2-pole, 3-phase slotless structure. The permanent magnet is centrally located inside the hollow shaft. Multi-strand twisted Litz-wire is used to reduce eddy current loss in the winding. The criteria of selecting materials for the super-high speed and cryogenic application are presented. Possible structures of the rotor and stator are considered and simulated using finite element method (FEM). Mechanical stress simulation and rotor dynamic issues are also considered. The connections of low pass filters to reduce switching harmonics of pulse-width modulation (PWM) and to reduce circulating current are also discussed. The first prototype has been fabricated and tested at room temperature. Projected total efficiency of the motor is over 90%
Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius detected in the BfT-GermVet monitoring programme 2004-2006 in Germany.

OBJECTIVES During recent years, methicillin-resistant Staphylococcus aureus (MRSA) strains from animals have become the focus of various studies. In the present study, coagulase-positive staphylococci obtained from pigs, dogs and cats suffering from acute infections, which had been collected in the BfT-GermVet monitoring programme in Germany and phenotypically identified as oxacillin-resistant, were characterized. METHODS The staphylococci were comparatively investigated for their resistance phenotypes and genotypes. Resistance genes were identified by PCR. MRSA strains were further characterized by SmaI macrorestriction analysis and spa typing to assess their genomic relationships. RESULTS Among the 248 strains tested, 7 strains (5 porcine S. aureus and 2 canine Staphylococcus pseudintermedius) carried the resistance gene mecA. Gentamicin resistance was based on the presence of the gene aacA/aphD while three different tetracycline resistance genes, tet(K), tet(L) and tet(M), alone or in combinations, were detected. The single macrolide/lincosamide-resistant strain carried an erm(A) gene. All MRSA strains proved to be non-typeable by SmaI macrorestriction analysis and exhibited the spa types t011 (four strains) or t034 (one strain). CONCLUSIONS Based on their spa types and their non-respondence to SmaI digestion, all five porcine MRSA strains resembled MRSA strains of multilocus sequence type ST398, previously detected among pigs in neighbouring countries such as The Netherlands or Denmark. The results of this study indicate that such strains are also involved in defined disease conditions of pigs from various parts of Germany.
Mental health knowledge management: critical success factors and strategy of implementation

Purpose This paper aims to recommend implementation of the knowledge management (KM) strategy for a mental health organisation, an area that has, to date, limited attention in literature based on the factors that influence KM success. Design/methodology/approach A mixed-methods research was conducted to identify the organisational culture, resources, enablers and the influential factors of mental health knowledge management (MHKM). The data were collected in five referral mental hospitals and were analysed using quantitative, qualitative and triangulation methods. Findings The organisational culture has become a great barrier. Forty-three influential factors were identified. Otherwise, based on culture, resources, enablers and strengthen, weakness, opportunities and threaten (SWOT) analysed were adopted to propose ten of the critical success factors and were recommended into an implementation strategy. Research limitations/implications The paper has proven that KM is a new and emerging discipline in Indonesia, especially on mental health care. This will contribute to the governmental policy of KM implementation and enforce the quality of services. Practical implications This result has the potential to leverage interdisciplinary KM research. It supports a mental health organisation in applying KM. Originality/value This study is probably the first to analyse factors that are of influence in an MHKM initiative programme.
Community-Based Question Answering via Heterogeneous Social Network Learning

Community-based question answering (cQA) sites have accumulated vast amount of questions and corresponding crowdsourced answers over time. How to efficiently share the underlying information and knowledge from reliable (usually highly-reputable) answerers has become an increasingly popular research topic. A major challenge in cQA tasks is the accurate matching of high-quality answers w.r. t given questions. Many of traditional approaches likely recommend corresponding answers merely depending on the content similarity between questions and answers, therefore suffer from the sparsity bottleneck of cQA data. In this paper, we propose a novel framework which encodes not only the contents of question-answer(Q-A) but also the social interaction cues in the community to boost the cQA tasks. More specifically, our framework collaboratively utilizes the rich interaction among questions, answers and answerers to learn the relative quality rank of different answers w.r. t a same question. Moreover, the information in heterogeneous social networks is comprehensively employed to enhance the quality of question-answering (QA) matching by our deep random walk learning framework. Extensive experiments on a large-scale dataset from a real world cQA site show that leveraging the heterogeneous social information indeed achieves better performance than other state-of-the-art cQA methods.
"Normothermic range" temperature affects myocardial infarct size.

OBJECTIVES This study tested the hypothesis that small changes in temperature above the hypothermic range may alter myocardial infarct size after acute coronary occlusion-reperfusion. A secondary hypothesis, that a correlation between temperature and infarct size may be independent of an associated change of heart rate, was also evaluated. METHODS Eighteen pentobarbitone-anaesthetised, open chest rabbits underwent 30 min coronary artery occlusion and 3 h reperfusion at blood temperatures ranging from 35-42 degrees C, achieved and maintained using surface methods (not paced, group NP). In a second group of 11 animals, heart rate was held constant across the same range of temperatures (paced, group P), before and throughout coronary artery occlusion-reperfusion. Infarct sizes were assessed by the tetrazolium method. RESULTS Target temperature was effectively controlled over the duration of the experimental protocol to within +/- 0.25 degrees C. Area at risk did not vary with temperature. Infarct size, normalised to area at risk, was correlated with temperature in both groups (infarct size = 7.9 x temp-250.0, r = 0.75, p = 0.0003, group NP; infarct size = 11.7 x temp-404.5, r = 0.88, p = 0.0004, group P). There was no significant difference between the slopes of these two lines (p = 0.18), indicating that the positive correlation between infarct size and temperature is not related to changes of heart rate. CONCLUSION Temperatures in the range of 35-42 degrees C affect myocardial infarct size significantly, independent of heart rate.
A ug 2 01 7 Learning with Optimal Interpolation Norms ∗

We analyze a class of norms defined via an optimal interpolation problem involving the composition of norms and a linear operator. This construction, known as infimal postcomposition in convex analysis, is shown to encompass various of norms which have been used as regularizers in machine learning, signal processing, and statistics. In particular, these include the latent group lasso, the overlapping group lasso, and certain norms used for learning tensors. We establish basic properties of this class of norms and we provide dual norms. The extension to more general classes of convex functions is also discussed. A stochastic block-coordinate version of the Douglas-Rachford algorithm is devised to solve minimization problems involving these regularizers. A prominent feature of the algorithm is that it yields iterates that converge to a solution in the case of non smooth losses and random block updates. Finally, we present numerical experiments with problems employing the latent group lasso penalty.
Contractual Terms and Conditions in Private Equity Partnership Agreements 1

Private equity partnerships are commonly regarded as examples of long-term commitment contracts. Limited partners commit the entire capital of the fund up-front and may face expensive default penalties for not honoring a capital call. Commitment, however, may be perceived to be stronger than it actually is, as explicit early termination provisions are often included. We develop a model to show how the degree of commitment can be used to screen general partners according to their managerial ability. Our model generates new predictions on the use of default penalties, on the investment strategy, and on the fee structures of general partners.
The Mystery of Success for Small Businesses: Evidence from the United Kingdom

Using a sample of small businesses in the United Kingdom, the current study comprehensively and systematically investigates the determinants that influence the profitability of small businesses over the period 2007 to 2015 under a Generalized Method of Moments (GMM) system estimator. The current study significant contributes to the empirical literature by classifying the determinants into three groups, namely company specific determinants, industry-specific determinants as well as macroeconomic determinants. The current paper fills the gap in the empirical literature by a more advanced econometric technique and the robustness results are cross checked by different alternative indicators of the variables. The results show that the profitability of UK small business tends to be persistent to a small extent and the profitability is significantly affected by capital, cost of employees, gearing as well as economic growth.
Dampak ED PSAK 71 Intrumen Keuangan Terhadap Pedoman Akuntansi Perbankan Terkait Kredit

nIn late 2016, the Financial Accounting Standards Board published the Exposure Draft ofPSAK 71 to replace PSAK 55 Financial Instruments, which is planned effective as ofJanuary 1, 2019. Financial Instruments in the form ofcredit is a major asset in the Balance of Commercial Bank and Rural Bank, so that changes in accounting standards certainly impact on the accounting treatment ofcredit. The authors reviewed the literature related to PSAK 55 and ED PSAK 71. The results of the review come out with conclusions that will not be found impact significantly the ED PSAK 71 Financial Instruments in aspect ofcredit recognition in the financial statements ofCommercial Bank and Rural Bank. However it will be found significant impact ofED IAS 71 Financial Instruments in aspesk measurement and presentation of financial statements in general Bank and Rural Bank n Keywords: Commercial Bank, Rural Bank, Impairment, Measurement, Reporting. n
Multiresolution learning paradigm and signal prediction

Current neural network learning processes, regardless of the learning algorithm and preprocessing used, are sometimes inadequate for difficult problems. We present a new learning concept and paradigm for neural networks, called multiresolution learning, based on multiresolution analysis in wavelet theory. The multiresolution learning paradigm can significantly improve the generalization performance of neural networks.
Radiofrequency cardiac ablation with catheters placed on opposing sides of the ventricular wall: Computer modelling comparing bipolar and unipolar modes

Abstract Purpose: The aim of this study was to compare the efficacy of bipolar (BM) vs. unipolar (UM) mode of radiofrequency ablation (RFA) in terms of creating transmural lesions across the interventricular septum (IVS) and ventricular free wall (VFW). Materials and methods: We built computational models to study the temperature distributions and lesion dimensions created by BM and UM on IVS and VFW during RFA. Two different UM types were considered: sequential (SeUM) and simultaneous (SiUM). The effect of ventricular wall thickness, catheter misalignment, epicardial fat, and presence of air in the epicardial space were also studied. Results: Regarding IVS ablation, BM created transmural and symmetrical lesions for wall thicknesses up to 15 mm. SeUM and SiUM were not able to create transmural lesions with IVS thicknesses ≥12.5 and 15 mm, respectively. Lesions were asymmetrical only with SeUM. For VFW ablation, BM also created transmural lesions for wall thicknesses up to 15 mm. However, with SeUM and SiUM transmurality was obtained for VFW thicknesses ≤7.5 and 12.5 mm, respectively. With the three modes, VFW lesions were always asymmetrical. In the scenario with air or a fat tissue layer on the epicardial side, only SiUM was capable of creating transmural lesions. Overall, BM was superior to UM in IVS and VFW ablation when the catheters were not aligned. Conclusions: Our findings suggest that BM is more effective than UM in achieving transmurality across both ventricular sites, except in the situation of the epicardial catheter tip surrounded by air or placed over a fat tissue layer.
CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation*

Background: CHFR is a tumor suppressor that arrests the cell cycle at prophase. Results: CHFR regulates the mitotic checkpoint via PARP-1 ubiquitination and degradation. Conclusion: The interaction between CHFR and PARP-1 plays an important role in cell cycle regulation and cancer therapy. Significance: Our data shed new light on a potential strategy for the combined usage of PARP inhibitors with microtubule inhibitors. The mitotic checkpoint gene CHFR (checkpoint with forkhead-associated (FHA) and RING finger domains) is silenced by promoter hypermethylation or mutated in various human cancers, suggesting that CHFR is an important tumor suppressor. Recent studies have reported that CHFR functions as an E3 ubiquitin ligase, resulting in the degradation of target proteins. To better understand how CHFR suppresses cell cycle progression and tumorigenesis, we sought to identify CHFR-interacting proteins using affinity purification combined with mass spectrometry. Here we show poly(ADP-ribose) polymerase 1 (PARP-1) to be a novel CHFR-interacting protein. In CHFR-expressing cells, mitotic stress induced the autoPARylation of PARP-1, resulting in an enhanced interaction between CHFR and PARP-1 and an increase in the polyubiquitination/degradation of PARP-1. The decrease in PARP-1 protein levels promoted cell cycle arrest at prophase, supporting that the cells expressing CHFR were resistant to microtubule inhibitors. In contrast, in CHFR-silenced cells, polyubiquitination was not induced in response to mitotic stress. Thus, PARP-1 protein levels did not decrease, and cells progressed into mitosis under mitotic stress, suggesting that CHFR-silenced cancer cells were sensitized to microtubule inhibitors. Furthermore, we found that cells from Chfr knockout mice and CHFR-silenced primary gastric cancer tissues expressed higher levels of PARP-1 protein, strongly supporting our data that the interaction between CHFR and PARP-1 plays an important role in cell cycle regulation and cancer therapeutic strategies. On the basis of our studies, we demonstrate a significant advantage for use of combinational chemotherapy with PARP inhibitors for cancer cells resistant to microtubule inhibitors.
A CMOS-Compatible, Low-Loss, and Low-Crosstalk Silicon Waveguide Crossing

We demonstrated a waveguide crossing for submicron silicon waveguides with average insertion loss of 0.18±0.03 dB and crosstalk of -41±2 dB, uniform across an 8-inch wafer. The device was fabricated in a CMOS-compatible process using 248 nm lithography, with only one patterning step.
Teachers' Use of the MABC Checklist to Identify Children with Motor Coordination Difficulties

Children with motor coordination problems often have difficulty succeeding in the classroom. No previous research could be located in which classroom teachers used screening tools to determine the severity of the children's motor coordination problems or their need for consultation from occupational and physical therapists. The purposes of this study were: 1) to examine the relationship between teachers' scores on the Movement Assessment Battery for Children (MABC) checklist and the physical therapist's scores on the MABC test; and 2) to examine the degree of concordance in decision making by determining if the teachers and physical therapist, using these two measures independently, identified the same children with motor difficulties and those without motor difficulties. Teachers completed the MABC checklist and the physical therapist administered the MABC test to 103 children. The relationship between the teachers' and physical therapist's scores was examined using the Pearson product-moment correlation. Sensitivity and specificity of the checklist were assessed with the MABC test scores as the criterion measure. The correlation between the teachers' scores and the physical therapist's scores was r = 0.51. The sensitivity of the checklist at the 15th percentile cutoff point was 14.3%, and specificity was 97.8%. The sensitivity of the MABC checklist was so low that many children at risk for motor problems based on the MABC test were not identified. Thus, the independent use of this checklist by teachers to identify children with motor coordination problems is not recommended.