Miracle-dz/UniFAR-FTUs huggingface dataset:
Applications of Neutron Scattering to Soft Condensed Matter

1. A Short Introduction to Neutron Scattering 2. Molecular Structures Determined by Neutron Diffraction 3. The Liquid Structure of Halocarbons 4. Using SANS to Study Adsorbed Layers in Colloidal Dispersions 5. Crystalline and Amorphous Polymers 6. Organization and Dynamics of Amphiliphilic Polymers at Fluid Interfaces 7. The Structure of Surfactanct Monolayers at Their Air-Water Inferface 8. Polymer Blends 9. Inelastic Neutron Scattering of Polymers 10. The Wonderful World of Ionomers 11. Neutron Scattering in Pharmaceutical Sciences
Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex

From an anatomical point of view the neocortex is subdivided into up to six layers depending on the cortical area. This subdivision has been described already by Meynert and Brodmann in the late 19/early 20. century and is mainly based on cytoarchitectonic features such as the size and location of the pyramidal cell bodies. Hence, cortical lamination is originally an anatomical concept based on the distribution of excitatory neuron. However, it has become apparent in recent years that apart from the layer-specific differences in morphological features, many functional properties of neurons are also dependent on cortical layer or cell type. Such functional differences include changes in neuronal excitability and synaptic activity by neuromodulatory transmitters. Many of these neuromodulators are released from axonal afferents from subcortical brain regions while others are released intrinsically. In this review we aim to describe layer- and cell-type specific differences in the effects of neuromodulator receptors in excitatory neurons in layers 2–6 of different cortical areas. We will focus on the neuromodulator systems using adenosine, acetylcholine, dopamine, and orexin/hypocretin as examples because these neuromodulator systems show important differences in receptor type and distribution, mode of release and functional mechanisms and effects. We try to summarize how layer- and cell type-specific neuromodulation may affect synaptic signaling in cortical microcircuits.
Tensor-Based Nonlinear Classifier for High-Order Data Analysis

In this paper we propose a tensor-based nonlinear model for high-order data classification. The advantages of the proposed scheme are that (i) it significantly reduces the number of weight parameters, and hence of required training samples, and (ii) it retains the spatial structure of the input samples. The proposed model, called Rank-1 FNN, is based on a modification of a feedforward neural network (FNN), such that its weights satisfy the rank-1 canonical decomposition. We also introduce a new learning algorithm to train the model, and we evaluate the Rank-1 FNN on third-order hyperspectral data. Experimental results and comparisons indicate that the proposed model outperforms state of the art classification methods, including deep learning based ones, especially in cases with small numbers of available training samples.
The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin

Aim. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated. Materials and Methods. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute. Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups. Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated. Results. The concentration of verteporfin in SLN was significantly higher than other organs. The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%). Conclusions. These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.
Detection of Laboratory False Negative Smears by the PAPNET Cytologic Screening System

OBJECTIVE To evaluate the ability of PAPNET-assisted screening to identify abnormal slides that had originally been reported as negative on manual screening. STUDY DESIGN One hundred ninety-five abnormal slides were seeded into 20,000 slides that had been assessed as showing no abnormality on two occasions by manual screening. All slides were submitted for PAPNET review and the tiles assessed by trained cytotechnologists. RESULTS With a single assessment of the PAPNET tiles and when the prevalence of seeded abnormality was around 1%, only 44% of the seeded abnormal slides were recognized as abnormal. With multiple independent assessments and by increasing the prevalence of abnormality to 81%, 83% of the seeded abnormalities were recognized by at least one of three reviewing cytotechnologists. This increase in sensitivity appeared to be associated with a state of relative hyperalertness in the reviewing cytotechnologists. CONCLUSION The sensitivity of a PAPNET-assisted review was < 100% for the detection of seeded abnormal slides. Altering the format of presentation of information to the cytotechnologist may result in improved sensitivity.
Aluminum Rod Extrusion and Material Modeling

The article presents an outline of a scientific approach for testing constitutive relations for the aluminum extrusion process. By comparing ram force, container friction, die face pressure, outlet temperature measurement during rod extrusion with corresponding simulated data, inferences can in principle be drawn with respect to the validity models. The paper indicates that simulation results from the 2D ALMA2π program are in fair agreement with measurements during extrusion of AA6060, but more work needs to be done to control thermal conditions during extrusion.
Phosphorylation at Ser8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue β-Amyloid (Aβ40) Fibrils*

Polymorphism of amyloid-β (Aβ) fibrils, implying different fibril structures, may play important pathological roles in Alzheimer's disease (AD). Morphologies of Aβ fibrils were found to be sensitive to fibrillation conditions. Herein, the Ser8-phosphorylated Aβ (pAβ), which is assumed to specially associate with symptomatic AD, is reported to modify the morphology, biophysical properties, cellular toxicity, and structures of Aβ fibrils. Under the same fibrillation conditions, pAβ favors the formation of fibrils (Fpβ), which are different from the wild-type Aβ fibrils (Fβ). Both Fβ and Fpβ fibrils show single predominant morphologies. Compared with Fβ, Fpβ exhibits higher propagation efficiency and higher neuronal cell toxicity. The residue-specific structural differences between the Fβ- and Fpβ-seeded Aβ fibrils were identified using magic angle spin NMR. Our results suggest a potential regulatory mechanism of phosphorylation on Aβ fibril formation in AD and imply that the post-translationally modified Aβ, especially the phosphorylated Aβ, may be an important target for the diagnosis or treatment of AD at specific stages.
Assumptions of Centering – Leveling Device Application in Mechatronic Angle Measuring System

This paper deals with the presentation of the new centering – leveling device developed in Vilnius Gediminas Technical University. Precision angle measuring systems are always combined of many mechanisms and devices which influence angle measurement accuracy. Therefore, every one of them has to be investigated separately. This device can be used as a separate device to perform a slight movement of measured object or it can be used as a part of mechatronic angle measuring system. This paper presents preliminary results of centering – leveling device minimum pitch determination and analysis of further development of this device as a part of mechatronic angle measuring system.
The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas.

Multiple oral doses of alpha-difluoromethyl-ornithine (alpha-DFMO), 18-24 g/day for up to 2 months, were administered to 2 patients with invasive and metastatic carcinoma of the bladder and to 3 patients with metastatic renal cancer in an open study. The moderate antigrowth effect of alpha-DFMO in these patients was concluded from the results of serial kidney, liver and bone scintigrams, from the low frequency of a local recurrence of bladder carcinoma and from the survival rate of 4 of 5 patients after 12 months. Increased excretion of hydroxyproline and beta2-microglobulin were measured 1 month following alpha-DFMO treatment suggesting initial tumor necrosis and degradation. Treatment was poorly tolerated with gastrointestinal side effects (e.g. gastritis, vomiting, diarrhea) in all subjects, erythropenia in 2 subjects (associated with thrombocytopenia and leucopenia in 1 subject each), and audiovestibular symptoms in 2 patients. All side effects were reversible and normal function returned 2-4 months after stopping therapy.
Experimental and Finite Element Analysis of Pultruded Glass-Graphite/Epoxy Hybrids in Axial and Flexural Modes of Vibration

The effects of hybridization on the extensional and flexural dynamic properties of pultruded composite materials are reported in this paper. The composite materials considered were made up of unidirectional glass, graphite fibers in an epoxy matrix, and hybrids of glass-graphite/epoxy produced by the pultrusion manufacturing process. The dynamic storage modulus and loss factor of the rectangular and circular cross-section samples were first evaluated using the nondestructive impulse-frequency response vibration technique. The long and slender flat specimens were analyzed in both extensional and flexural modes of vibration in a free-free test configuration, whereas the thicker round specimens were analyzed only in the axial mode of vibration. The properties of the monofiber type glass/epoxy and graphite/epoxy composites were used as input to the finite element model for predicting and experimental validation of various pultruded (and hypothetical) glass-graphite/epoxy hybrid combinations. The modal strain energy method was used for computing the structural loss factors of the hybrid specimens based on the element stiffness matrices and estimated mode shapes in the fundamental mode of vibration. Results of this investigation showed excellent agreement between experimental data and numerical predictions for the dynamic extensional properties of both flat and round specimens. The numerical results for dynamic flexural properties of flat specimens were found to have a similar trend as that obtained from the experimental technique. Small variations in flexural properties could be attributed to the irregular shapes (which were not taken into account in the finite element model) of layers in the hybrid combinations formed during the pultrusion manufacturing process. Results also demonstrated that while the extensional properties were independent of the fiber location and fiber packing geometry, the flexural properties were highly dependent upon these two factors. Previously reported data (which was obtained by testing these flat hybrid specimens in the flexural mode of vibration in a clamped-free boundary condition) were re-analyzed using the free-free configuration and modal strain energy method, yielding more reasonable results.
Ngā Whakāwhitinga (standing at the crossroads): How Māori understand what Western psychiatry calls “schizophrenia”

This project explored how Māori understand experiences commonly labelled “schizophrenic” or “psychotic”. Semi-structured interviews were conducted with 57 Māori participants who had either personal experiences labelled as “psychosis” or “schizophrenia”, or who work with people with such experiences; including tangata whaiora (users of mental health services), tohunga (traditional healers), kaumatua/kuia (elders), Māori clinicians, cultural support workers and students. Kaupapa Māori Theory and Personal Construct Theory guided the research within a qualitative methodology. The research found that participants held multiple explanatory models for experiences commonly labelled “psychotic” or “schizophrenic”. The predominant explanations were spiritual and cultural. It seems that cultural beliefs and practices related to mental health within Māori communities remain resilient, despite over a century of contact with mainstream education and health services. Other explanations included psychosocial constructions (interpersonal trauma and drug abuse), historical trauma (colonisation) and biomedical constructions (chemical brain imbalance). Participants (both tangata whaiora and health professionals) reported they were apprehensive about sharing their spiritual/cultural constructions within mainstream mental health settings due to fear of being ignored or pathologised. This study highlights the importance of asking users of mental health services about the meaning they place on their experiences and recognising that individuals can hold multiple explanatory models. Māori may hold both Māori and Pākehā (European) ways of understanding their experiences and meaningful recognition should be afforded to both throughout assessment and treatment planning in mental health services. Clinicians need to be aware that important personal and cultural meanings of experiences labelled psychotic may be withheld due to fear of judgement or stigmatisation.
Multi-swarm PSO algorithm for the Quadratic Assignment Problem: a massive parallel implementation on the OpenCL platform

This paper presents a multi-swarm PSO algorithm for the Quadratic Assignment Problem (QAP) implemented on OpenCL platform. Our work was motivated by results of time efficiency tests performed for single-swarm algorithm implementation that showed clearly that the benefits of a parallel execution platform can be fully exploited, if the processed population is large. The described algorithm can be executed in two modes: with independent swarms or with migration. We discuss the algorithm construction, as well as we report results of tests performed on several problem instances from the QAPLIB library. During the experiments the algorithm was configured to process large populations. This allowed us to collect statistical data related to values of goal function reached by individual particles. We use them to demonstrate on two test cases that although single particles seem to behave chaotically during the optimization process, when the whole population is analyzed, the probability that a particle will select a near-optimal solution grows.
Reduced Synapse and Axon Numbers in the Prefrontal Cortex of Rats Subjected to a Chronic Stress Model for Depression

Stressful experiences can induce structural changes in neurons of the limbic system. These cellular changes contribute to the development of stress-induced psychopathologies like depressive disorders. In the prefrontal cortex of chronically stressed animals, reduced dendritic length and spine loss have been reported. This loss of dendritic material should consequently result in synapse loss as well, because of the reduced dendritic surface. But so far, no one studied synapse numbers in the prefrontal cortex of chronically stressed animals. Here, we examined synaptic contacts in rats subjected to an animal model for depression, where animals are exposed to a chronic stress protocol. Our hypothesis was that long term stress should reduce the number of axo-spinous synapses in the medial prefrontal cortex. Adult male rats were exposed to daily stress for 9 weeks and afterward we did a post mortem quantitative electron microscopic analysis to quantify the number and morphology of synapses in the infralimbic cortex. We analyzed asymmetric (Type I) and symmetric (Type II) synapses in all cortical layers in control and stressed rats. We also quantified axon numbers and measured the volume of the infralimbic cortex. In our systematic unbiased analysis, we examined 21,000 axon terminals in total. We found the following numbers in the infralimbic cortex of control rats: 1.15 × 109 asymmetric synapses, 1.06 × 108 symmetric synapses and 1.00 × 108 myelinated axons. The density of asymmetric synapses was 5.5/μm3 and the density of symmetric synapses was 0.5/μm3. Average synapse membrane length was 207 nm and the average axon terminal membrane length was 489 nm. Stress reduced the number of synapses and myelinated axons in the deeper cortical layers, while synapse membrane lengths were increased. These stress-induced ultrastructural changes indicate that neurons of the infralimbic cortex have reduced cortical network connectivity. Such reduced network connectivity is likely to form the anatomical basis for the impaired functioning of this brain area. Indeed, impaired functioning of the prefrontal cortex, such as cognitive deficits are common in stressed individuals as well as in depressed patients.
Investigation on Wall Thinning and Creep Damage in Boiler Tube due to Scale Formation

Boiler is a closed vessel in which the water is heated up to convert it from the liquid phase to superheat steam at specified pressure by addition of heat. The tubes are operated continuously at high temperature due to the formation of scale which has lower conductivity than that of steel. The scale can be formed for various reasons of which tube geometries, flue gas and steam temperature are prominent. The remaining wall thickness decreases due to the formation of scale which eventually causes failure of the boiler tubes. In this investigation an iterative technique was used to determine the temperature distribution across the tube with the increase of operating time. The operating time was considered up to 160,000 hours. The remaining life of the steam generator tube was found by finding hoop stress and Larson Miller Parameter from the Larson Miller Parameter curve for SA213-T22 material. The remaining life of the steam generator tube was used to find cumulative creep damage. By utilizing finite element modelling software, ANSYS 9/ ANSYS 11 the temperature distribution across the steam generator tube was evaluated. The temperature distribution along with Larson Miller Parameter predicted the oxide scale thickness. It was also observed that different input parameters have pronounced affect on the formation of oxide scale inside the steam generator tube. By increasing the heat transfer rate across the wall, the oxide scale thickness was increased more rapidly than normal condition. It was also observed that due to formation of scale the thermal conductivity in the boiler tubes was affected and the remaining life of boiler tubes was decreased and accelerated creep damage.
Advances in the molecular diagnosis of diffuse large B-cell lymphoma in the era of precision medicine

ABSTRACT Introduction: The adoption of high-throughput technologies has led to a transformation in our ability to classify diffuse large B-cell lymphoma (DLBCL) into unique molecular subtypes. In parallel, the expansion of agents targeting key genetic and gene expression signatures has led to an unprecedented opportunity to personalize cancer therapies, paving the way for precision medicine. Areas covered: This review summarizes the key molecular subtypes of DLBCL and outlines the novel technology platforms in development to discriminate clinically relevant subtypes. Expert commentary: The application of emerging diagnostic tests into routine clinical practise is gaining momentum following the demonstration of subtype specific activity by novel agents. Co-ordinated efforts are required to ensure that these state of the art technologies provide reliable and clinically meaningful results accessible to the wider haematology community.
Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study.

AIM We performed serial intracoronary studies of patients with stable coronary artery disease (CAD) to investigate the relationships among baseline endothelial shear stress (ESS), CAD progression, and vascular remodelling. Local haemodynamic factors are critical determinants of plaque progression, vascular remodelling, and clinical CAD manifestations. METHODS AND RESULTS The 3-D anatomy of coronary arteries with lumen obstruction <50% was determined by fusing intracoronary ultrasound and angiographic images in 13 patients at baseline and 8 +/- 2 months later. Cross-sectional area of plaque, lumen, and external elastic membrane (EEM), and coronary flow were measured. Local ESS was calculated. Subsegments with similar ESS were categorized based on low (<12 dynes/cm(2)) and moderate/higher ESS (> or =12 dynes/cm(2)). There were 47 subsegments of similar baseline ESS: nine with low ESS and 38 with moderate/higher ESS. Median subsegment length was 6.9 mm (25th-75th percentiles = 4.2-12.0), and median area of similar ESS of 52.6 mm(2) (25th-75th percentiles = 26.9-88.0). Subsegments with low ESS exhibited plaque progression when compared with subsegments with moderate/higher ESS (33.3% vs. 7.9%, respectively, P = 0.009 adjusted for clustering of lesions within patients) and constrictive remodelling (44.0% vs. 5.3%, respectively, P = 0.16 adjusted for clustering of lesions within patients). Expansive remodelling occurred with similar frequency in subsegments with low vs. moderate/higher baseline ESS. CONCLUSION Plaque progresses in subsegments with low ESS, associated with either constrictive or expansive remodelling. Different mechanisms are likely responsible for expansive remodelling in different local vascular environments. Early in vivo identification of arterial subsegments likely to develop high-risk plaque characteristics may allow for selective interventions to avoid adverse cardiac outcomes.
The Economic Consequences of Hospital Admissions

We use an event study approach to examine the economic consequences of hospital admissions for adults in two datasets: survey data from the Health and Retirement Study, and hospitalization data linked to credit reports. For non-elderly adults with health insurance, hospital admissions increase out-of-pocket medical spending, unpaid medical bills and bankruptcy, and reduce earnings, income, access to credit and consumer borrowing. The earnings decline is substantial compared to the out-of-pocket spending increase, and is minimally insured prior to age-eligibility for Social Security Retirement Income. Relative to the insured non-elderly, the uninsured non-elderly experience much larger increases in unpaid medical bills and bankruptcy rates following a hospital admission. Hospital admissions trigger less than 5 percent of all bankruptcies.