Miracle-dz/UniFAR-FTUs huggingface dataset:
A study on underdetermined DOA estimation techniques based on higher-order correlation analysis utilizing non-linear mapping

Direction Of Arrival (DOA) estimation is a traditional research subject in array signal processing. Because of the importance of DOA information in many applications, a wide range of studies have already been reported. However, representative high-resolution DOA estimatiors suffer from a notable problem that they are constrained by the signal dimensionality and cannot estimate DOAs in underdetermined cases, where the number of sources exceeds the number of sensors. Although several conventional methods, exploiting higher order cumulants of signals, have been proposed to overcome the problem, they also have another shortcoming for the short-time analysis. Therefore, we set our research goal to propose a novel approach that can estimate DOAs with high resolution even in underdetermined conditions and achieve superior estimation accuracy in short-time analysis. The work for this study is mainly two-fold. First, we establish concept of our proposed method employing higher-dimensional nonlinear mapping. By increasing signal dimensionality with the mapping, we extend the analysis of MUltiple SIgnal Classification (MUSIC), the representative high-resolution DOA estimator, to the underdetermined DOA estimation. Furthermore, for the higher estimation accuracy in short-time analysis, we propose a class of mapping which enables us to analyze higher order moments of signals. Through the comparisons focusing on the biasvariance tradeoff between moment and cumulant, we demonstrate the superiority of the proposed method for short-time analysis in terms of both estimation accuracy and computational complexity. Next, for the further improvement of estimation accuracy, we propose an extension of the proposed method. We describe an algorithm that utilizes multiple maps simultaneously for the joint analysis of moment of multiple high orders. Also, we discuss the advantage of this approach and conduct experiments to evaluate its effectiveness. Experimental results reveal that the extended proposed method achieves quite higher estimation accuracy than other conventional methods.
Logistics optimization for dispositions and depooling of product distillates in oil-refineries : closing the production scheduling and primary distribution gap

At the edge of the manufacturing of crude-oil distillates into refined final products, the production scheduling and primary distribution gap can be reduced by optimizing production rundown switches of dispositions of distillates in a mixed-integer linear model (MILP) considering discrete time-steps of days, shifts or hours for a delivery horizon of weeks or months. From the process network down to the product distribution side, there are definitions on the assignments, allocations and amounts of distillates to be dispatched downstream. Other challenges involve logistics and quality aspects in further processshops and blend-shops considering diverse tank farms and various transport modes for the distribution. However, such integration of the refining process and tank storage systems can become intractable for industrial-sized problems with complex scheduling configurations considering time-varying rundown supply rates, product demands and pricing. For this, we propose to model the dispositions of distillates using unit-operations as modes of transportation from the distillation sources to the tanks of process-shops and blend-shops for downstream processing and blending before the primary distribution. Additionally, by solving with pooling (groups of tanks) first then post-solve to depool by disaggregating the pooled solution, the determination of the distillate dispositions to tank assignments is facilitated given that scaling to industrial-sized cases without tank aggregation is complicated as highlighted in the examples. Better prediction of the operations scheduling by using small discrete time-steps within a planning horizon allows opportunities for exploring the contract and spot market plays of the finished products.
The Factors Affecting Tourist Visits at Owabong Waterpark in Bojongsari Sub-district of Purbalingga

This research aimed to determine the effect of income, travel cost, distance and visitor age on the number of tourist visit to Owabong Waterpark. This research is a survey research to visitors of Owabong Waterpark using accidental sampling method. Qualitative and quantitative data was derived questionnaire based interview technique. This research used multiple linear regression analysis with double log model. The result indicated that income had a positive effect on tourist visits at Owabong Waterpark. Travel cost and distance have insignificant effect on tourist visits at Owabong Waterpark. Age had insignificant effect on tourist visits at Owabong Waterpark. The implication of this research for the management of Owabong Waterpark is to continously improve the existing facilities and infrastructures to maintain the quality of tourist attraction, always innovate various vehicles attracting the visitors, conduct promotions such as discounted ticket to reach all income groups, conduct more vigorous promotions, especially in social media to be better known by the community outside Purbalingga so that Owabong Waterpark is not only visited by local tourists, but also foreign tourists. Keywords: Income, Travel Cost, Distance, Age, Social Media.
Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin

Excessive activation of the complement system is detrimental in acute inflammatory disorders. In this study, we analyzed the role of complement‐derived anaphylatoxins in the pathogenesis of experimental acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in C57BL/6J mice. Intratracheal administration of recombinant mouse complement component (C5a) caused alveolar inflammation with abundant recruitment of Ly6‐G+CD11b+ leukocytes to the alveolar spaces and severe alveolar‐capillary barrier dysfunction (C5a‐ALI; EC50[C5a] = 20 ng/g body weight). Equimolar concentrations of C3a or desarginated C5a (C5adesArg) did not induce alveolar inflammation. The severity of C5a‐ALI was aggravated in C5‐deficient mice. Depletion of Ly6‐G+ cells and use of C5aR1‐/‐ bone marrow chimeras suggested an essential role of C5aR1+ hematopoietic cells in C5a‐ALI. Blockade of PI3K/Akt and MEK1/2 kinase pathways completely abrogated lung injury. The mechanistic description is that C5a altered the alveolar cytokine milieu and caused significant release of CC‐chemokines. Mice with genetic deficiency of CC‐chemokine receptor (CCR) type 5, the common receptor of chemokine (C‐C motif) ligand (CCL) 3, CCL4, and CCL5, displayed reduced lung damage. Moreover, treatment with a CCR5 antagonist, maraviroc, was protective against C5a‐ALI. In summary, our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1, which may be evaluated for potential therapeutic exploitation in ALI/ARDS. —Russkamp, N. F. , Ruemmler, R. , Roewe, J., Moore, B. B. , Ward, P. A. , Bosmann, M. Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin. FASEB J. 29, 3762‐3772 (2015). www.fasebj. org
The Juvenile Arthritis Quality of Life Questionnaire--development of a new responsive index for juvenile rheumatoid arthritis and juvenile spondyloarthritides.

OBJECTIVE To develop a disease specific measure of quality of life for application in children with juvenile rheumatoid arthritis and juvenile spondyloarthritides-the Juvenile Arthritis Quality of Life Questionnaire (JAQQ). METHODS Patients and their parents were interviewed by a trained interviewer using a questionnaire focusing on physical function, psychosocial function, and general symptoms to determine the most appropriate items to include in the JAQQ. Respondents volunteered items and scored them for frequency of occurrence and importance. Items so generated were scored by a panel of experts for potential responsiveness and categorized into dimensions. Item number was reduced using this scoring system. The product was then pretested to confirm its construct validity and responsiveness. Thereafter, it was distributed to clinical experts to establish face and content validity. RESULTS 91 patients, mean age 10.35 years (range 1.25-18.0), mean disease duration 3.99 years, and their parents were included in the interview process. 220 items generated were ultimately reduced to 85. Pretesting this version of the instrument in a further 30 patients showed it to have construct validity and responsiveness and led to a further reduction in items to 74, distributed in 4 dimensions: gross motor function (17 items), fine motor function (16 items), psychosocial function (22 items), and general symptoms (19 items). Face and content validity were established in 20 clinicians. Scaling was by 7 point Likert scale to enhance responsiveness. English and French versions were developed. CONCLUSION The JAQQ measures physical and psychosocial function and an array of general symptoms. Preliminary data suggest it is valid and responsive and thus might have potential in clinical trials.
Immunologic considerations for therapeutic strategies utilizing allogeneic hepatocytes: Hepatocyte‐expressed membrane‐bound major histocompatibility complex class I antigen sensitizes while soluble antigen suppresses the immune response in rats

Understanding the immunologic effects of hepatocytes is critical because of the potential to use these cells for bioartificial livers, as a vehicle for gene transfer, and as a means to induce donor‐specific immunosuppression in organ transplantation. However, this understanding is complicated by the fact that hepatocytes express membrane‐bound and soluble forms of major histocompatibility complex (MHC) class I antigen, each with the potential to induce different immune responses. In the present study we first determined the immunologic effect of normal donor‐derived hepatocytes in a rat heart transplant model. We then used ex vivo hepatocyte gene transfer to examine the immunologic effects of different forms of hepatocyte‐expressed MHC class I antigen. Results showed that intrasplenic injection of purified, donor‐strain–specific hepatocytes into recipients primes alloimmunity, as evidenced by acceleration of heart allograft rejection. Interestingly, injection of autologous hepatocytes transfected ex vivo with DNA encoding only membrane‐bound donor MHC class I antigen (RT1.Aa) also accelerated allograft rejection. However, hepatocytes transfected to express only secreted donor MHC antigen prolonged transplant survival. Limiting‐dilution analysis of lymphocytes from animals treated with hepatocytes producing only secreted alloantigen showed an antigen‐specific reduction in cytotoxic T lymphocyte (CTL) and helper T lymphocyte (HTL) precursors. Further analysis of CTL populations by flow cytometry revealed a relatively high percentage of nonviable cells, implying that soluble antigen promotes allospecific CTL death. In summary, this study suggests that hepatocyte‐expressed MHC class I molecules have opposing immunologic effects, with the membrane‐bound antigen inducing immunologic sensitization, and the soluble antigen promoting donor‐specific immunosuppression.
Protozoologica Protozoa and Oxygen

Aerobic protozoa can maintain fully aerobic metabolic rates even at very low O2-tensions; this is related to their small sizes. Many – or perhaps all – protozoa show particular preferences for a given range of O2-tensions. The reasons for this and the role for their distribution in nature are discussed and examples of protozoan biota in O2-gradients in aquatic systems are presented. Facultative anaerobes capable of both aerobic and anaerobic growth are probably common within several protozoan taxa. It is concluded that further progress in this area is contingent on physiological studies of phenotypes.
Knowledge, Fairness, and Social Constraints

In the context of fair allocation of indivisible items, fairness concepts often compare the satisfaction of an agent to the satisfaction she would have from items that are not allocated to her: in particular, envy-freeness requires that no agent prefers the share of someone else to her own share. We argue that these notions could also be defined relative to the knowledge that an agent has on how the items that she does not receive are distributed among other agents. We define a family of epistemic notions of envy-freeness, parameterized by a social graph, where an agent observes the share of her neighbours but not of her non-neighbours. We also define an intermediate notion between envy-freeness and proportionality, also parameterized by a social graph. These weaker notions of envy-freeness are useful when seeking a fair allocation, since envy-freeness is often too strong. We position these notions with respect to known ones, thus revealing new rich hierarchies of fairness concepts. Finally, we present a very general framework that covers all the existing and many new fairness concepts.
A Surface Phospholipase Is Involved in the Migration of Plasmodium Sporozoites through Cells*

Plasmodium sporozoites, injected by mosquitoes into the skin of the host, traverse cells during their migration to hepatocytes where they continue their life cycle. The mechanisms used by the parasite to rupture the plasma membrane of the host cells are not known. Here we report the presence of a phospholipase on the surface of Plasmodium berghei sporozoites (P. berghei phospholipase; Pb PL) and demonstrate that it is involved in the establishment of a malaria infection in vivo. Pb PL is highly conserved among the Plasmodium species. The protein is about 750 amino acids, with a predicted signal sequence and a carboxyl terminus that is 32% identical to the vertebrate lecithin:cholesterol acyltransferase, a secreted phospholipase. Pb PL contains a motif characteristic of lipases and a catalytic triad of a serine, aspartate, and histidine that is found in several phospholipases. We have verified its lipase and membrane lytic activity in vitro, using recombinant baculovirus-expressed protein. To study its role in vivo, we have disrupted the P. berghei PL open reading frame and generated mutants in its active site. During an infection through mosquito bite, the infectivity of the knock-out parasites in the liver is decreased by ∼90%. The prepatent period of the resulting blood infection is 1 day longer as compared with wild type. Further, the mutant sporozoites are impaired in their ability to cross epithelial cell layers. Thus, the Pb PL functions as a lipase to damage cell membranes and facilitates sporozoite passage through cells during their migration from the skin to the bloodstream.
Femtosecond laser ablation of enamel Quang-Tri

The surface topographical, compositional, and structural modifications induced in human enamel by femtosecond laser ablation is studied. The laser treatments were performed using a Yb:KYW chirped-pulseregenerative amplification laser system (560 fs and 1030 nm) and fluences up to 14 J∕cm2. The ablation surfaces were studied by scanning electron microscopy, grazing incidence x-ray diffraction, and micro-Raman spectroscopy. Regardless of the fluence, the ablation surfaces were covered by a layer of resolidified material, indicating that ablation is accompanied by melting of hydroxyapatite. This layer presented pores and exploded gas bubbles, created by the release of gaseous decomposition products of hydroxyapatite (CO2 and H2O) within the liquid phase. In the specimen treated with 1-kHz repetition frequency and 14 J∕cm2, thickness of the resolidified material is in the range of 300 to 900 nm. The micro-Raman analysis revealed that the resolidified material contains amorphous calcium phosphate, while grazing incidence x-ray diffraction analysis allowed detecting traces of a calcium phosphate other than hydroxyapatite, probably β-tricalcium phosphate Ca3ðPO4Þ2, at the surface of this specimen. The present results show that the ablation of enamel involves melting of enamel’s hydroxyapatite, but the thickness of the altered layer is very small and thermal damage of the remaining material is negligible. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) [DOI: 10.1117/1.JBO. 21.6. 065005]
Modelling of information system using object-oriented approach

The paper discusses an information system for control and supervision of power transmission network in the Republic of Croatia. For upgrading the existing system, various types of information models have been analyzed and compared to find a model that would satisfy the needs of an efficient management and control of an electric power system and electricity market. The models analyzed include a device model, an object-oriented approach model, and the models based on IEC standards. Examples are given for application of modelling to a group of process information facilitating supervision and control of electric power systems. The models were compared with respect to the characteristics included in the information system modelling by application of an object-oriented approach. The result of the analysis was a model that can satisfy the demands set for supervision, control and implementation of electricity market functions.
Combined effect of astaxanthin and squalene on oxidative stress in vivo

Title Combined effect of astaxanthin and squalene on oxidative stress in vivo Author(s) Kumar, Sangeetha Ravi; Narayan, Bhaskar; Sawada, Yuki; Hosokawa, Masashi; Miyashita, Kazuo Citation Molecular and cellular biochemistry, 417(1-2): 57-65 Issue Date 2016-06 Doc URL http://hdl.handle. net/2115/65792 Rights The final publication is available at link.springer. com Type article (author version) File Information Sangeetha et al (2016)-MCB-MS Revised-2.pdf
Analysis of CMR images within an integrated healthcare framework for remote monitoring

We present a software for analyzing Cardiac Magneti c Resonance (CMR) images. This tool has been developed in a frame work of a European Project aiming to provide the physicians with suppo rt f r treatment monitoring and for taking appropriate actions in both the clin i al and home environments. The software includes modules for the detection, se gmentation and estimation of quantitative parameters of scars and for a funct io al analysis of the heart.
Multicenter randomized clinical trial of goserelin versus surgical ovariectomy in premenopausal patients with receptor-positive metastatic breast cancer: an intergroup study.

PURPOSE To compare failure-free survival (FFS) and overall survival (OS) for patients with metastatic breast cancer treated with the gonadotropin-releasing hormone (GN-RH) agonist, goserelin versus surgical ovariectomy. PATIENTS AND METHODS Between August 1, 1987 and July 15, 1995 138 (136 eligible) premenopausal patients with estrogen receptor (ER)- and/or progesterone receptor (PgR)-positive metastatic breast cancer were entered by the Southwest Oncology Group (SWOG), North Central Cancer Treatment Group (NCCTG), and Eastern Cooperative Oncology Group (ECOG). Prior chemotherapy or hormone therapy for metastatic disease was not allowed. Patients were randomly assigned to goserelin (3.6 mg subcutaneously every 4 weeks; (n = 69) versus surgical ovariectomy (n = 67). The study was initially designed as an equivalence trial with 80% power to rule out a 50% improvement in survival due to ovariectomy. However, accrual was slow and the study was terminated early, which resulted in a final power of 60% for the alternative hypothesis of equal survival distributions. RESULTS FFS and OS were similar for goserelin and ovariectomy. The goserelin/ovariectomy death hazards ratio was . 80 and the associated 95% confidence interval (CI) was . 53 to 1.20. The test of 50% improvement in survival due to ovariectomy was rejected at P = . 006. Goserelin lowered serum estradiol to postmenopausal levels. Hot flashes (75% v 46%) and tumor flare (16% v 3%) were more common with goserelin. CONCLUSION Goserelin and ovariectomy resulted in similar FFS and OS. We can rule out a moderate advantage for ovariectomy. Goserelin was safe and well tolerated.
The pht4;1-3 mutant line contains a loss of function allele in the Fatty Acid Desaturase 7 gene caused by a remnant inactivated selection marker—a cautionary tale

A striking and unexpected biochemical phenotype was found in an insertion mutant line in the model plant Arabidopsis thaliana. One of two investigated insertion mutant lines in the gene encoding the phosphate transporter PHT4;1 demonstrated a prominent loss of trienoic fatty acids, whereas the other insertion line was indistinguishable from wild type in this aspect. We demonstrate that the loss of trienoic fatty acids was due to a remnant inactive negative selection marker gene in this particular transposon tagged line, pht4;1-3. This constitutes a cautionary tale that warns of the importance to confirm the loss of this type of selection markers and the importance of verifying the relationship between a phenotype and genotype by more than one independent mutant line or alternatively genetic complementation.
CLASSIFICATION THEORY OF SIMPLE LOCALLY FINITE GROUPS BY SIMON RHYS THOMAS A thesis submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY at BEDFORD COLLEGE, UNIVERSITY OF LONDON

This thesis constitutes a contribution to applied stability theory. We consider the classification problem of the stable simple locally finite groups. First the classification of the finite simple groups is used to reduce the problem to an identification problem for the simple locally finite groups of Lie type and an interpretation problem in model theoretic algebra. In chapter three, the identification problem is solved. It is shown that the union of a chain of groups of the same Lie type over finite fields is a group of Lie type over a locally finite field. This result, together with the classification of the finite simple groups, implies that an infinite simple periodic linear group is a group of Lie type over a locally finite field. The next two chapters solve the interpretation problem, and complete the proof that a stable simple locally finite group is a Chevalley group over an algebraically closed field. We also show that the class of Chevalley groups of a fixed Lie type is finitely axiomatisable. Chapter six contains a partial classification of the nonsoluble locally finite groups of finite Morley rank. In the final chapter, we show that a simple constructible group over an algebraically closed field is a Chevalley group. The proof is model theoretic, and makes no use of algebraic geometry or Lie algebras. This result can be regarded as a nonstandard corollary of the classification of the finite simple groups.