Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Efficient Detection of Overlapping Communities in Massive Networks

Community detection is essential to analyzing and exploring natural networks such as social networks, biological networks, and citation networks. However, few methods could be used as off-the-shelf tools to detect communities in real world networks for two reasons. On the one hand, most existing methods for community detection cannot handle massive networks that contain millions or even hundreds of millions of nodes. On the other hand, communities in real world networks are generally highly overlapped, requiring that community detection method could capture the mixed community membership. In this paper, we aim to offer an off-the-shelf method to detect overlapping communities in massive real world networks. For this purpose, we take the widely-used Poisson model for overlapping community detection as starting point and design two speedup strategies to achieve high efficiency. Extensive tests on synthetic and large scale real networks demonstrate that the proposed strategies speedup the community detection method based on Poisson model by 1 to 2 orders of magnitudes, while achieving comparable accuracy at community detection.
Small dose of naloxone as an adjuvant to bupivacaine in intrapleural infiltration after thoracotomy surgery: a prospective, controlled study

Background Severe pain always develops after thoracotomy; intrapleural regional analgesia is used as a simple, safe technique to control it. This study was performed to evaluate whether a small dose of naloxone with local anesthetics prolongs sensory blockade. Methods A prospective, randomized double-blinded controlled study was conducted on 60 patients of American Society of Anesthesiologists statuses I and II, aged 18 to 60 years, scheduled for unilateral thoracotomy surgery. After surgery, patients were randomly divided into two groups: through the intrapleural catheter, group B received 30 ml of 0.5% bupivacaine, while group N received 30 ml of 0.5% bupivacaine with 100 ng of naloxone. Postoperative pain was assessed using the visual analog pain scale (VAS). Time for the first request for rescue analgesia, total amount consumed, and incidence of postoperative complications were also recorded. Results The VAS score significantly decreased in group N, at 6 h and 8 h after operation (P < 0.001 for both). At 12 h after injection, the VAS score increased significantly in group N (P < 0.001). The time for the first request of rescue analgesia was significantly longer in group N compared to group B (P < 0.001). The total amount of morphine consumed was significantly lower in group N than in the bupivacaine group (P < 0.001). Conclusions Addition of a small dose of naloxone to bupivacaine in intrapleural regional analgesia significantly prolonged pain relief after thoracotomy and delayed the first request for rescue analgesia, without significant adverse effects.
Theoretical model of purchase and repurchase in internet shopping: evidence from japanese online customers

Studies on factors affecting the intention to purchase and repurchase in Internet shopping have been conducted for many years. However, these investigations were generally separated into two parts: the effect of factors on intention to purchase and the effects of factors on intention to repurchase. This study, therefore, aims to develop a purchase-repurchase model for Internet shopping which integrates three theoretical models- the technology acceptance model (TAM), expectation-confirmation theory (ECT), and the model of intention, adoption, and continuance (MIAC). The model consists of three processes: intention to purchase, actual purchase, and intention to repurchase. The model was used to investigate the factors affecting each process. The investigation was carried out via an online survey among online customers of a web-based portal website in Japan in 2006. The results of 1,215 Japanese online customers showed that the model is able to explain and predict their Internet shopping purchase-repurchase behaviors substantially well. Moreover, each process was been tested to determine if it was affected by the characteristics (gender, marital status, age group, income level, education level, net-orientation, and innovativeness) of online customers. Only age group, net-orientation, and innovativeness affected all purchase-repurchase processes. The findings and managerial implications are also discussed.
Synthesis and Characterization of Polyhydroxyalkanoate Organo/Hydrogels.

Synthetic organogels/hydrogels are attracting growing interests due to their potential applications in biomedical fields, organic electronics, and photovoltaics. Photogelation methods for synthesis of organogels/hydrogels have been shown particularly promising because of the high efficiency and simple synthetic procedures. This study synthesized new biodegradable polyhydroxyalkanoates (PHA)-based organogels/hydrogels via UV photo-cross-linking using unsaturated PHA copolymer poly[( R)-3-hydroxyundecanoate- co-( R)-3-hydroxy-10-undecenoate] (PHU10U) with polyethylene glycol dithiol (PDT) as a photo-cross-linker. The PHU10U was synthesized by an engineered Pseudomonas entomophila and characterized via Fourier transform infrared spectroscopy, 1H nuclear magnetic resonance (NMR), and 13C NMR. With decreasing the molar ratio of PHU10U to PDT, both the swelling ratio and pore size were decreased. Meanwhile, increasing densities of the gel networks resulted in a higher compressive modulus. Cell cytotoxicity studies based on the CCK-8 assay on both the PHU10U precursor and PHU10U/PDT hydrogels showed that the novel PHA-based biodegradables acting as hydrogels possess good biocompatibility.
Cultural Heritage 'In-The-Wild': Considering Digital Access to Cultural Heritage in Everyday Life

As digital cultural heritage applications begin to be deployed outwith ‘traditional’ heritage sites (such as museums, open-air museums or galleries), there is an increased need to consider their use amongst individuals who are open to learning about the heritage of a site, but where that is a clearly secondary purpose of their visit. Parks, recreational areas and the everyday built environment represent places that although often rich in heritage, are often not visited primarily to access that heritage. We present the results of a study of a mobile application, called Explore, that supports accessing heritage on a Finnish recreational island. Evaluation with 45 participants, who were not visiting primarily to access the heritage, provided insight into how digital heritage applications can be developed for this user group. Our results showed how low immersion and lightweight interaction support individuals to integrate cultural heritage around their primary visit purpose. Although participants were willing to include heritage as part of their visit, they were not willing to be directed by Explore. Our work outlines future directions that should be considered when expanding the reach of heritage access beyond ‘traditional’ sites.
Location-Sensitive User Profiling Using Crowdsourced Labels

In this paper, we investigate the impact of spatial variation on the construction of location-sensitive user profiles. We demonstrate evidence of spatial variation over a collection of Twitter Lists, wherein we find that crowdsourced labels are constrained by distance. For example, that energy in San Francisco is more associated with the green movement, whereas in Houston it is more associated with oil and gas. We propose a three-step framework for location-sensitive user profiling: first, it constructs a crowdsourced label similarity graph, where each labeler and labelee are annotated with a geographic coordinate; second, it transforms this similarity graph into a directed weighted tree that imposes a hierarchical structure over these labels; third, it embeds this location-sensitive folksonomy into a user profile ranking algorithm that outputs a ranked list of candidate labels for a partially observed user profile. Through extensive experiments over a Twitter list dataset, we demonstrate the effectiveness of this location-sensitive user profiling.
Does Social Capital Benefit Older Adults’ Health and Well-Being? The Mediating Role of Physical Activity

Objectives: To assess whether social capital benefits older adults’ self-rated health and well-being and whether physical activity mediates this relation. Methods: A survey study was conducted among members of a sociocultural organization (age ≥55 years), both cross-sectionally (baseline Time 1; N = 959) and longitudinally (3-year follow-up Time 2; N = 409). Results: Specific indicators of social capital were positively, though modestly, related to health and well-being at Time 1 and Time 2. Experienced connectedness with age peers emerged as the strongest predictor. Physical activity only mediated the relation with experienced safety in society. Discussion: The relative importance of older adults’ experienced connectedness with their age peers underlines the importance of internalized group membership as a determinant of their health and well-being. Physical activity seems to play only a minor mediating role.
MyBackPain—evaluation of an innovative consumer-focused website for low back pain: study protocol for a randomised controlled trial

Introduction Despite the prevalence of low back pain (LBP) worldwide, many people with the condition do not receive evidence-based care or achieve the best possible outcomes. There is a gap in the dissemination of evidence-based information across the globe. The advent of the internet has changed the way people obtain health information. As such, trustworthy, tailored and validated LBP resources may help bridge the gap. This study aims to measure the effectiveness of a new website (MyBackPain) in improving spinal health literacy, treatment preferences and clinical outcomes for people with LBP, in comparison with other online resources. Methods and analysis This online, pragmatic, randomised controlled trial will comprise 440 people with non-specific LBP of any duration. In addition to access to publicly available online information (control group), the intervention group will be given access to the MyBackPain.org. au website. Participants and research staff, including the biostatistician, will be blinded to treatment allocation. Data will be collected at baseline, 1, 3 (primary end-point), 6 and 12 months via online surveys and questionnaires. The primary outcome is spinal health literacy. Secondary outcomes include quality of treatment preferences (stated and observed) and LBP clinical outcomes (pain, disability and quality of life). Analyses will be by intention-to-treat and include outcome data on all randomised participants. Descriptive statistics will be presented for demographic and clinical characteristics. Ethics and dissemination This trial has been prospectively registered with the Australian New Zealand Clinical Trials Registry and has ethical approval from the University of Queensland Human Research Ethics Committee (2017000995). Trial outcomes will be shared via national and international conference presentations and peer-reviewed journal publications. Trial registration number ACTRN12617001292369; Pre-results.
Superoxide increases surface NKCC2 in the rat thick ascending limbs via PKC.

The apical Na+-K+-2Cl- cotransporter (NKCC2) mediates NaCl reabsorption by the thick ascending limb (TAL). The free radical superoxide ( O2- ) stimulates TAL NaCl absorption by enhancing NKCC2 activity. In contrast, nitric oxide (NO) scavenges O2- and inhibits NKCC2. NKCC2 activity depends on the number of NKCC2 transporters in the TAL apical membrane and its phosphorylation. We hypothesized that O2- stimulates NKCC2 activity by enhancing apical surface NKCC2 expression. We measured surface NKCC2 expression in rat TALs by surface biotinylation and Western blot analysis. Treatment of TALs with O2- produced by exogenous xanthine oxidase (1 mU/ml) and hypoxanthine (500 µM) stimulated surface NKCC2 expression by ~18 ± 5% (P < 0.05). O2- -stimulated surface NKCC2 expression was blocked by the O2- scavenger tempol (50 µM). Scavenging H2O2 with 100 U/ml catalase did not block the stimulatory effect of xanthine oxidase-hypoxanthine (22 ± 8% increase from control, P < 0.05). Inhibition of endogenous NO production with Nω-nitro-l-arginine methyl ester enhanced surface NKCC2 expression by 21 ± 6% and, when added together with xanthine oxidase-hypoxanthine, increased surface NKCC2 by 41 ± 10% (P < 0.05). Scavenging O2- with superoxide dismutase (300 U/ml) decreased this stimulatory effect by 60% (39 ± 4% to 15 ± 10%, P < 0.05). Protein kinase C inhibition with Gö-6976 (100 nM) blocked O2- -stimulated surface NKCC2 expression (P < 0.05). O2- did not affect NKCC2 phosphorylation at Thr96/101 or its upstream kinases STE20/SPS1-related proline/alanine-rich kinase-oxidative stress-responsive kinase 1. We conclude that O2- increases surface NKCC2 expression by stimulating protein kinase C and that this effect is blunted by endogenous NO. O2- -stimulated apical trafficking of NKCC2 may be involved in the enhanced surface NKCC2 expression observed in Dahl salt-sensitive rats.
Calibration of fluorescence imaging for tumor surgical margin delineation: multistep registration of fluorescence and histological images

Abstract. Although a greater extent of tumor resection is important for patients’ survival, complete tumor removal, especially tumor margins, remains challenging due to the lack of sensitivity and specificity of current surgical guidance techniques at the margins. Intraoperative fluorescence imaging with targeted fluorophores is promising for tumor margin delineation. To verify the tumor margins detected by the fluorescence images, it is necessary to register fluorescence with histological images, which provide the ground truth for tumor regions. However, current registration methods compare fluorescence images to a single-layer histological slide, which is selected subjectively and represents a single plane of the three-dimensional tumor. A multistep pipeline is established to correlate fluorescence images to stacked histological images, including fluorescence calibration and multistep registration. Multiple histological slices are integrated as a two-dimensional (2-D) tumor map using optical attenuation model and average intensity projection. A BLZ-100-labeled medulloblastoma mouse model is used to test the whole framework. On average, the synthesized 2-D tumor map outperforms the selected best slide as ground truth [Dice similarity coefficient (DSC): 0.582 versus 0.398, with significant differences; mean area under the curve (AUC) of the receiver operating characteristic curve: 88% versus 85.5%] and the randomly selected slide as ground truth (DSC: 0.582 versus 0.396 with significant differences; mean AUC: 88% versus 84.1% with significant differences), which indicates our pipeline is reliable and can be applied to investigate targeted fluorescence probes in tumor margin detection. Following this proposed pipeline, BLZ-100 shows enhancement in both tumor cores and tumor margins (mean target-to-background ratio: 8.64 ± 5.76 and 4.82 ± 2.79, respectively).
Decoupling GPU Programming Models from Resource Management for Enhanced Programming Ease, Portability, and Performance

The application resource specification--a static specification of several parameters such as the number of threads and the scratchpad memory usage per thread block--forms a critical component of modern GPU programming models. This specification determines the parallelism, and hence performance, of the application during execution because the corresponding on-chip hardware resources are allocated and managed based on this specification. This tight-coupling between the software-provided resource specification and resource management in hardware leads to significant challenges in programming ease, portability, and performance. Zorua is a new resource virtualization framework, that decouples the programmer-specified resource usage of a GPU application from the actual allocation in the on-chip hardware resources. Zorua enables this decoupling by virtualizing each resource transparently to the programmer. We demonstrate that by providing the illusion of more resources than physically available via controlled and coordinated virtualization, Zorua offers several important benefits: (i) Programming Ease. Zorua eases the burden on the programmer to provide code that is tuned to efficiently utilize the physically available on-chip resources. (ii) Portability. Zorua alleviates the necessity of re-tuning an application's resource usage when porting the application across GPU generations. (iii) Performance. By dynamically allocating resources and carefully oversubscribing them when necessary, Zorua improves or retains the performance of applications that are already highly tuned to best utilize the resources.
Neurogenesis as a potential therapeutic strategy for neurodegenerative disorders.

The discovery that new neurons could be observed in post-natal rodent brain was reported in the early 1960s [1–3], but only gained wider acceptance when a potential source of this “neurogenesis” was identified. Since the 1990s, progenitors for the main neural cell types had been isolated from rodent [45,49,58,59] and human adult or fetal brain tissue [11,63]. These isolated progenitors, or stem cells, are unique in their ability to self-renew and to differentiate, in a multipotential manner, into astrocytes, oligodendrocytes and neurons. In mouse and human stem cells, single growth factor treatment allows for continued proliferation or for differentiation toward a particular neural fate [28, 33,60,64]. At the same time that investigators were beginning to understand the multipotential nature of the isolated progenitors, the localization of in vivo neurogenesis to discrete areas of the brain were described. In rodents [4,32] and in non-human [23] and human primates [16], immunohistological examination determined that the areas of greatest concentration of new neurons in the adult brain are located in the subventricular zone, where they migrate to the olfactory bulb and in the subgranular zone of dentate gyrus. Results from the isolation of post-mortem human brain tissue, suggest that new neurons can be formed in the dentate gyrus well into adulthood [46]. It is important to note, when discussing neurogenesis, that three apparent stages exist, first the point of neural stem cell proliferation in the subgranular zone or subventricular zone, then the migration, on differentiation, to the granule cell layers, and finally the maturation with generation of functional neural networks for surviving neurons. Mitogen, growth factor and cytokine control of each neurogenesis step in isolated fetal neural progenitors [9,19,28] imply that each stage is finely regulated and deviations in for instance growth factor levels, could have physiological consequences. Accordingly, increases in proliferation of stem cells or neuronal progenitors promoted by the mitogen, basic fibroblast growth factor (bFGF), followed by differentiation to neurons, subsequently requires addition of brain-derived neurotrophic factor (BDNF) to maintain survival and arborization of the new neurons. It appears that only 50% of new neurons in the granule layer of dentate gyrus or new neurons in the olfactory bulb survive to maturity, normally a 2–4 week process. This observation could be important if neurogenesis is going to be exploited for therapeutic purposes.
Continuing competency in ethical decision making: An interpretive description of occupational therapists’ perspectives

Background. Competency in ethical decision making is a criterion for ethical practice, and it is expected to advance with ongoing professional development. However, research exploring continuing competency needs of occupational therapists regarding ethical decision making is limited. Purpose. The purpose of this study was to explore potential gaps and directions for development related to continuing competency in ethical decision making from the perspective of practicing occupational therapists. Method. Interpretive description informed secondary data analysis of professional narratives from a grounded theory study regarding ethical decision making. In-depth interviews were conducted with a purposive sample of 18 occupational therapists. Data analyses focused on identifying gaps and future directions regarding continuing competency. Findings. Two main themes regarding gaps were identified: “I didn’t have the knowledge” and “I don’t have anybody. ” Education, tool development, and ethics mentorship were identified directions for development. Implications. Findings advance understanding of continuing competency needs of occupational therapists regarding ethical decision making.
Parental Involvement and Executive Function in Emerging Adults with Type 1 Diabetes.

OBJECTIVE To examine (a) changes in parental involvement across early emerging adulthood, (b) whether yearly fluctuations in parental involvement were associated with adherence and glycated hemoglobin (HbA1c) over time, and (c) whether higher involvement was more beneficial for those with poorer executive function (EF). METHODS A total of 228 high school seniors (M age = 17.76) with type 1 diabetes reported on mothers' and fathers' acceptance, knowledge of diabetes activities, disclosure to mothers and fathers regarding diabetes, and adherence at four yearly time points. At baseline, participants completed performance-based measures of EF. HbA1c was collected from assay kits. RESULTS Growth curve models revealed significant declines in disclosure to fathers and mothers' and fathers' knowledge of diabetes activities; no changes were found in mothers' or fathers' acceptance nor disclosure to mothers. Multilevel models indicated significant between-person effects for nearly all aspects of parental involvement with more acceptance, knowledge, and disclosure associated with better HbA1c and adherence. Within-person effects for disclosure to fathers, and mothers' and fathers' knowledge indicated that in years when emerging adults perceived higher amounts of these types of involvement (compared with their own average), HbA1c was lower. Within-person effects were found for acceptance to mothers, disclosure to mothers and fathers, and mothers' diabetes knowledge for adherence. Disclosure to fathers and mothers' knowledge of diabetes activities were especially beneficial for HbA1c for those with poorer EF performance. CONCLUSIONS Parental involvement in diabetes management remains important during the high-risk time of emerging adulthood, especially for those with poorer EF.