Miracle-dz/UniFAR-FTUs huggingface dataset:
Cation distribution and intrinsic magnetic properties of Co‐Ti‐doped M‐type barium ferrite

The structural and magnetic properties of BaFe12−2xCoxTixO19 (0≤x≤1.0) M‐type barium ferrite have been investigated by means of neutron powder diffraction and high‐field magnetization measurements. The cationic distribution and magnetic moments of the five different metallic sublattices are determined and compared to the experimental saturation magnetization. It is found that about 50% of Co ions occupy tetrahedral sites, thus being ineffective in the reduction of the uniaxial magnetic anisotropy, while Ti ions prefer the 4fVI octahedral sites. All in all, a clear hierarchy of sublattice preferences is defined. Although the collinearity of the magnetic structure is progressively broken, mainly above x≊0.7, the overall behavior remains ferrimagnetic. The strong local spin canting is tentatively attributed to the localization of diamagnetic Ti ions in the 4fVI octahedral sites.
On Summarizing Large-Scale Dynamic Graphs

How can we describe a large, dynamic graph over time? Is it random? If not, what are the most apparent deviations from randomness – a dense block of actors that persists over time, or perhaps a star with many satellite nodes that appears with some ﬁxed periodicity? In practice, these deviations indicate patterns – for example, research collaborations forming and fading away over the years. Which patterns exist in real-world dynamic graphs, and how can we ﬁnd and rank their importance? These are exactly the problems we focus on. Our main contributions are (a) formulation : we show how to formalize this problem as minimizing an information theoretic encoding cost, (b) algorithm : we propose T IME C RUNCH , an effective and scalable method for ﬁnding coherent, temporal patterns in dynamic graphs and (c) practicality : we apply our method to several large, diverse real-world datasets with up to 36 million edges and introduce our auxiliary ECO VIZ framework for visualizing and interacting with dynamic graphs which have been summarized by T IME C RUNCH . We show that T IME C RUNCH is able to compress these graphs by summarizing important temporal structures and ﬁnds patterns that agree with intuition.
Invasive weed optimisation inspired fuzzy-rough feature selection

Feature selection is a dimensionality reduction technique with the purpose of selecting those input features that are most predictive of a given outcome. The benefits of feature selection include simplified feature internal-relationship and improved prediction performance. Methods based on fuzzy-rough set theory have employed the dependency function to guide the feature selection process with much success. This paper further extends the fuzzy-rough feature selection (FRFS) by using the invasive weed optimisation (IWO) strategy. The advantage of IWO is that the offspring individuals are randomly spread around their parents according to a Gaussian distribution during the evolution process. Such Gaussian distribution is designated with a dynamical standard deviation. Therefore, the optimisation algorithm can explore a new solution space aggressively to maintain the diversity of the species in the early and middle iterations, and the optimal individuals in final iteration of feature selection. The mechanism of IWO ensures a global optimal solution for the heuristic search. The experimental results indicate that the use of IWO in fuzzy-rough feature selection can result in smaller subset sizes than those obtained through FRFS with PSO and ACO search strategies, with an increase in overall classification performances.
Mating system in Mexican populations of the annual herb Solanum rostratum Dunal (Solanaceae).

Traditionally, annual colonising species are expected to have high rates of self-fertilisation, although recent theoretical and empirical studies have shown that cross-fertilisation can be selected for under heterogeneous pollination environments. Solanum rostratum is a self-compatible annual herb that colonises disturbed habitats. Despite the lack of physiological mechanisms to prevent self-fertilisation, pollen transfer between individuals is expected to be favoured because of its complex floral morphology. In previous studies of S. rostratum it has been shown that anther dimorphism within flowers results in precise pollen placement on the pollinator's body, and the presence of mirror-image floral morphs within plants promotes outcrossing in experimental arrays. However, the mating system of natural populations of S. rostratum has never been assessed, and thus whether it is predominantly selfing or outcrossing remains unknown. We hypothesise that floral and inflorescence morphology of S. rostratum should facilitate cross-fertilisation, making it a predominantly outcrossing despite its lack of a self-incompatibility system. To test this hypothesis, we estimated outcrossing rates by genotyping 700 individuals at 13 microsatellite loci, sampled from four populations across a 690-km transect in the species' native range. We found that populations had mean outcrossing rates of 0.70 ± 0.03, with multiple sires contributing to paternity of each progeny array (average effective number of sires = 8.97 ± 0.57). This indicates that natural populations S. rostratum have relatively high levels of outcrossing, probably facilitated by its floral and inflorescence morphology. We speculate that partial selfing in this species may be an unavoidable consequence of displaying multiple flowers at the same time (geitonogamy), as well as the result of self-pollen transfer by illegitimate visitors.
Playing Action Video Games Improves Visuomotor Control

Can playing action video games improve visuomotor control? If so, can these games be used in training people to perform daily visuomotor-control tasks, such as driving? We found that action gamers have better lane-keeping and visuomotor-control skills than do non–action gamers. We then trained non–action gamers with action or nonaction video games. After they played a driving or first-person-shooter video game for 5 or 10 hr, their visuomotor control improved significantly. In contrast, non–action gamers showed no such improvement after they played a nonaction video game. Our model-driven analysis revealed that although different action video games have different effects on the sensorimotor system underlying visuomotor control, action gaming in general improves the responsiveness of the sensorimotor system to input error signals. The findings support a causal link between action gaming (for as little as 5 hr) and enhancement in visuomotor control, and suggest that action video games can be beneficial training tools for driving.
Cyclosporine A up-regulates angiotensin II receptors and calcium responses in human vascular smooth muscle cells.

BACKGROUND The most widely used immunosuppressive drug for preventing graft rejection and treating autoimmune diseases is currently cyclosporine A (CsA). However, CsA also causes vasoconstriction, which is considered to be at the origin of CsA-induced nephrotoxicity and hypertension. To evaluate the cellular basis for these side effects, we studied the influence of CsA on the regulation of the free cytosolic Ca2+ concentration ([Ca2+]c) in cultured human vascular smooth muscle cells (SMCs). METHODS SMCs were isolated from the medial layer of human aorta. [Ca2+]c regulation was studied by fluorimetry with fura 2 and by measuring 45Ca2+ effluxes. Angiotensin II (Ang II) receptors were detected by [125I]Ang II binding. RESULTS Pretreatment of human SMCs for 24 hours with CsA in its therapeutic concentration range (0. 1 to 10.0 microM) had no effect on basal [Ca2+]c, but increased the [Ca2+]c elevation and 45Ca2+ efflux when cells were stimulated with Ang II. Half-maximal effects occurred at approximately 1 microM CsA. The CsA effects on [Ca2+]c were accompanied by a nearly twofold increase in Ang II receptor number, whereas no change in affinity to Ang II was observed. CsA did not alter endothelin-1- or thapsigargin-induced 45Ca2+ efflux. Increases in both Ca2+ responses and [125I]Ang II binding were attenuated by the transcriptional inhibitor actinomycin D. The effects of CsA did not appear to be mediated by calcineurin inhibition because cyclosporine H, which is not immunosuppressive, also increased the Ang II-induced 45Ca2+ efflux. CONCLUSION These data suggest that CsA preferentially up-regulates the transcription of Ang II receptors, which very likely leads to vasoconstriction in vivo and could be at the origin of CsA-induced hypertension and nephrotoxicity in humans.
In Vitro Study of Thrombin on Tubule Formation and Regulators of Angiogenesis

Objective: Angiogenesis occurs within atherosclerotic plaques, and thrombin has been implicated in plaque progression by increasing smooth muscle cell proliferation and upregulating Vascular Endothelial Growth Factor (VEGF) receptor expression. This study investigated the effects of thrombin on key aspects of angiogenesis and expression of pro- and anti-angiogenic regulators: VEGF and Pigment Epithelial Derived Factor. Research Design and Methods: Human umbilical smooth muscle cells (HUASMC) were exposed to vehicle or thrombin at 10 U/ml. To quantify cell proliferation, methyl tetrazolium salt (MTS) solution was added after exposure to thrombin for 24, 48 and 72 hours and the absorbance at 490nm recorded using a plate reader. For Real-time RT-PCR cells were exposed to thrombin for 24hr before analysis of VEGF and PEDF mRNA. A commercial Angiokit was used to construct an in vitro angiogenesis model to measure tubule formation and branching. After 12 days treatment with thrombin 10 U/ml, cells were fixed and the AngioSys 1.0 software was used to analyse tubule morphology. Results: In comparison with controls, thrombin significantly increased HUASMC proliferation (p = 0.002, n = 11) and VEGF mRNA expression by 93% (n = 4, p = 0.024). However in the HUVEC/fibroblast co-cultures it decreased the number of junctions [132(9) vs 196(18), n = 6, p = 0.017] and tubules [537 (17) vs 589 (26), n = 6, p = 0.049], and tubule length [11393 (1601) vs 12195 (1014), n = 6, p = 0.044], indicating an anti-angiogenic effect. Conclusions: Thrombin stimulates vascular smooth muscle cell proliferation and VEGF expression, but attenuates endothelial cell-mediated growth of vascular tubules and branching of new vascular structures.
How does Social Media Analytics Create Value?

The surge of interest in big social data has led to growing demand for social media analytics SMA. Having robust SMA can help firms create value and achieve competitive advantages. However, most firms do not always know how to embrace big social data to establish a path to value. This study addresses this key question to deepen our understanding of how different types of SMA can be applied to create value. Specifically, the findings show the significant uses of opinion mining or sentiment analysis, topic modeling, engagement analysis, predictive analysis, social network analysis, and trend analysis. Finally, the study provides directions for the challenges and opportunities of SMA to maximize value.
Abdominal image segmentation using three-dimensional deformable models.

RATIONALE AND OBJECTIVES The authors develop a three-dimensional (3-D) deformable surface model-based segmentation scheme for abdominal computed tomography (CT) image segmentation. METHODS A parameterized 3-D surface model was developed to represent the human abdominal organs. An energy function defined on the direction of the image gradient and the surface normal of the deformable model was introduced to measure the match between the model and image data. A conjugate gradient algorithm was adapted to the minimization of the energy function. RESULTS Test results for synthetic images showed that the incorporation of surface directional information improved the results over those using only the magnitude of the image gradient. The algorithm was tested on 21 CT datasets. Of the 21 cases tested, 11 were evaluated visually by a radiologist and the results were judged to be without noticeable error. The other 10 were evaluated over a distance function. The average distance was less than 1 voxel. CONCLUSIONS The deformable model-based segmentation scheme produces robust and acceptable outputs on abdominal CT images.
THE LIFE AND WORK OF ASTLEY COOPER

MR. BROCK, who considers that Astley Cooper "has not received that acknowledgment wvhich he deserves," has given us a most interesting account of the work of this remarkable surgeon. From his appointment to the staff at Guy's Hospital in 1800 till his death in 1841 he held a leading place in British surgery, both as surgeon and teacher. His lectures at one time attracted as many as 400 students, and his "Lectures on Surgery" was for many years the standard textbook-indeed it still has a place on your reviewer's book shelf. His surgical prowess was astonishing; it is difficult to imagine the courage and skill required to ligate the abdominal aorta for aneurysm, or disarticulate at the hip joint in the conditions of his time. Even the apparently trivial operation of excision of a sebaceous cyst from the scalp of King George IV, for which he received his Baronetcy, was not without risk. But the main theme of this book is that Astley Cooper made many and valuable contributions to surgery. He was a student of John Hunter, and was obviously influenced by that great master. His best known and most important books were on hernia, and the anatomy of the breast although his name is perpetuated in both regions, it is not generally known that he was the first to describe and name the transversalis fascia. This book will be of great interest to modern surgeons, many of whom will be surprised to learn how much of their knowledge springs from the work of Astley Cooper. It is appropriate that this tribute to the memory of the "Greatest of Guy's Surgeons" should come from the pen of one so distinguished to-day. T. L. K.
Bupropion as an Add-on Therapy in Depressed Bipolar Disorder Type I Patients With Comorbid Cocaine Dependence

ObjectivesThe treatment of bipolar disorder type I (BD-I) with a comorbid cocaine dependence disorder (CDD) is a challenge in current psychiatric practice. Drugs with proven efficacy in manic/mixed episodes, such as atypical antipsychotics and mood stabilizers, sometimes do not prevent depressive relapses; on the other hand, the use of antidepressants during acute depressive episodes may increase the risk of a manic switch. The aim of the present study was to investigate the short-term efficacy of bupropion augmentation in acutely depressed BD-I patients with co-occurring CDD. MethodsTwelve depressed BD-I patients, with a comorbid CDD, treated with valproate 1000 to 1500 mg/d and aripiprazole 10 mg/d, were randomly assigned to receive bupropion 150 mg/d as an open-label add-on therapy (n = 5) or to continue their previous treatment (n = 7). ResultsAfter 4 weeks of observation, patients receiving add-on therapy with bupropion have improved in terms of Hamilton Depression Rating Scale scores and Drug Abuse Screening Test scores, with respect to those of the comparison group, whereas no significant increase of Young Mania Rating Scale scores over time was observed. ConclusionsOur preliminary findings suggest that combining bupropion with mood stabilizers and atypical antipsychotics may be a good therapeutic option in short-term treatment of depressed BD-I patients with comorbid CDD.
Integrating Abductive and Constraint Logic Programming

Over the recent years it has become apparent that applications of abduction depend significantly on the ability to integrate abductive reasoning with specialised constraint solving. In this paper we investigate this integration within the framework of Logic Programming by studying the integration of Abductive Logic Programming(ALP) and Constraint Logic Programming(CLP). ALP and CLP share common features that enable their natural integration both at a semantic and computational level. Both extensions can be understood within a common conceptual framework where an answer to a query is a formula involving only a special set of predicates, abducible or constraint predicates respectively, which is “satisfiable” under a special theory. This theory is for the case of ALP a set of problem specific integrity constraints whereas for the case of CLP this is a built-in constraint theory. The paper presents a way of integrating these two frameworks in a strongly correlated way where the two main tasks of abductive reasoning and constraint solving cooperate in a non-trivial way to solve goals. One of the main features of the integrated framework is that it allows a simpler representation of problems, close to their high-level specification, combined with the efficiency of specialised constraint solving. The paper presents the semantics of the integrated framework, by suitably combining the central notions of abductive explanation in ALP and constraint solving in CLP, together with a general proof procedure for goal satisfaction, which interleaves hypotheses and constraint generation with consistency checking and constraint satisfaction.
NETosis Delays Diabetic Wound Healing in Mice and Humans

Upon activation, neutrophils undergo histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and enzymes as neutrophil extracellular traps (NETs), and death. In diabetes, neutrophils are primed to release NETs and die by NETosis. Although this process is a defense against infection, NETosis can damage tissue. Therefore, we examined the effect of NETosis on the healing of diabetic foot ulcers (DFUs). Using proteomics, we found that NET components were enriched in nonhealing human DFUs. In an independent validation cohort, a high concentration of neutrophil elastase in the wound was associated with infection and a subsequent worsening of the ulcer. NET components (elastase, histones, neutrophil gelatinase-associated lipocalin, and proteinase-3) were elevated in the blood of patients with DFUs. Circulating elastase and proteinase-3 were associated with infection, and serum elastase predicted delayed healing. Neutrophils isolated from the blood of DFU patients showed an increased spontaneous NETosis but an impaired inducible NETosis. In mice, skin PAD4 activity was increased by diabetes, and FACS detection of histone citrullination, together with intravital microscopy, showed that NETosis occurred in the bed of excisional wounds. PAD4 inhibition by Cl-amidine reduced NETting neutrophils and rescued wound healing in diabetic mice. Cumulatively, these data suggest that NETosis delays DFU healing.
INDEPENDENT DEDUPLICATION IN DATA CLEANING #

Many organizations collect large amounts of data to support their business and decision-making processes. The data originate from a variety of sources that may have inherent data-quality problems. These problems become more pronounced when heterogeneous data sources are integrated (for example, in data warehouses). A major problem that arises from integrating different databases is the existence of duplicates. The challenge of de-duplication is identifying “equivalent” records within the database. Most published research in de-duplication propose techniques that rely heavily on domain knowledge. A few others propose solutions that are partially domain-independent. This paper identifies two levels of domain-independence in de-duplication namely: domainindependence at the attribute level, and domain-independence at the record level. The paper then proposes a positional algorithm that achieves domain-independent deduplication at the attribute level, and a technique for field weighting by data profiling, which, when used with the positional algorithm, achieves domain-independence at the record level. Experiments show that the proposed techniques achieve more accurate deduplication than the existing algorithms.
The Laws of Ur-Nammu

Yale University New Haven, Conn. , U. S. A. Having previously undertaken a investigation of the Sumerian laws relating to sexual offences,l prompted by the new source material published by Civil and Gurney & IVramer inthe Landsberger Festschrift, i soon became apparent, especially in light of the two fragments from a single tablet from Ur which Gurney and Isramer immediately perceived tobe part of the lass-"code" of Ur-Nammu that a reconsideration of the entire text of the Laws of Ur-Nammu was now needed, with a view towards establishing the interrelationship between the Ur fragments and the Nippur tablet N 3191 ( Or 23 pl. IV-VII ), including the possibility ofconstructing a single continuous text of the laws on the basis of the two extant manuscripts. That such a text edition might be feasible suggestei itself with the realization that the last line of col. ii of the Ur fragment U. 7739 is not to be read a n s e(! ) . as given by Gurney & IVramer in their transliteration, but gi r p [ad d u], which should provide a correspondence with the same word occurring inline 334 of the Nippur tablet. Subsequent s udy, as will be elaborated below, suggests that this is probably not precisely the case. The clue was nevertheless sufficient to indicate that the Ur tablet (when complete) did not contain five columns on the obverse, as its two editors believed and as Gurnev drew it in outline on p. 18, but only four. Thus, the first column of the second Ur fragment, U. 7740, which the editors designated as "col. iii" of the reconstructed whole tablet, is in fact only
Construction and Modeling of a Variable Collective Pitch Coaxial UAV

This paper describes the construction and modeling of a coaxial unmanned aerial vehicle for in-forest operation. The bare helicopter platform is upgraded and mounted with an onboard navigation system, which includes central processing units and sensors such as inertial measurement unit, camera and scanning laser range finder. The model structure of the helicopter is formulated, in which the model of rotor thrust and rollpitch dynamics are described in details. The flapping dynamics of the rotor and the stabilizer bar are presented and lumped into a state-space model. The parameters of the state-space model are identified in frequency domain using CIFER. Time domain verification with a new set of flight data exhibits excellent agreement with the prediction of the identified model.