Miracle-dz/UniFAR-FTUs huggingface dataset:
Station clustering strategy for DCF-based centralized OFDMA WLAN systems

To enhance the throughput of orthogonal frequency division multiple access (OFDMA) wireless local area network (WLAN) systems, this paper proposes a stations-clustering strategy in which stations in the basic service set (BSS) are grouped into clusters. In the proposed scheme, initially, to obtain statistics required for calculating the expected throughput achieved by OFDMA WLAN when the stations are grouped into a certain clustered-pattern, the access point (AP) and all stations belong to the same cluster and transmit DATA frames for a certain period. After that, the AP calculates the expected throughput for all clustered-patterns and chooses a clustered-pattern that maximizes the expected throughput. Then, the stations are grouped into clusters in accordance with the selected clustered-pattern, and the stations within the same cluster share the radio resource by OFDMA WLAN scheme. Numerical simulation confirms that the proposed scheme can maximize throughput performance by introduction of dynamic station clustering in the single BSS environment and it is also effective in preventing channel state information (CSI) feedback blocking due to station exposition in the overlapping BSS environment.
Emotion acceptance behavior therapy for anorexia nervosa: a pilot study.

OBJECTIVE This study aimed to evaluate the preliminary effectiveness of Emotion Acceptance Behavior Therapy (EABT), an outpatient psychotherapeutic intervention for anorexia nervosa (AN) based on a disorder-specific model of symptom maintenance that emphasizes emotion avoidance. EABT combines standard behavioral interventions that are central to the clinical management of AN with evidence-supported strategies to increase emotion awareness, decrease emotion avoidance, and encourage resumption of valued activities and relationships outside the eating disorder. METHOD Twenty-four individuals aged ≥17 years with AN were treated using the EABT manual. EABT was delivered in 33-58 individual sessions provided over 38-53 weeks. Assessments were conducted before and after treatment, and at 3- and 6-month follow-ups. RESULTS Thirteen patients (54.2%) completed EABT; 11 (45.8%) dropped out or were withdrawn. EABT was associated with significant improvements in weight, disordered eating symptoms, and emotion avoidance that were maintained over 6-month follow-up. The majority of EABT completers achieved a body mass index >18.5 (n = 9/13) or had a normal Eating Disorder Examination Global score (n = 10/13) at post-treatment. DISCUSSION Preliminary data suggest that EABT may have utility for a subset of adults with AN. Future research will focus on improving outcomes in EABT nonresponders and identifying of mechanisms that drive treatment response.
The Structure of Ethnic Inequality and Ethnic Voting

Why do some ethnic groups vote along ethnic lines while others do not? In this article, we theorize that the level of ethnic voting depends, partially, on how ethnicity interacts with economic cleavages. Specifically, we argue that between–ethnic group inequality (BGI) increases ethnic voting and that its effect strengthens as within–ethnic group inequality (WGI) decreases. We thus posit that the full structure of ethnic inequality, not only between-group differences, matters for ethnic voting. After presenting our argument, we conduct the first cross-national test of whether the effect of between-group inequality on ethnic voting is conditional on the level of inequality within ethnic groups. Our analysis employs group-level data on 200 ethnic groups from 65 countries. We find strong support for our hypothesis: BGI increases ethnic voting, but its effect is conditional on WGI.
Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90

Significance Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including 60% of the human kinases. Previous studies on the Hsp90–kinase interaction were limited due to the particular instability of client kinases. Here, we reconstituted v-Src kinase chaperoning in vitro and used this to mechanistically elucidate how Hsp90 supports kinases. We show that its activation is ATP-dependent and requires the phosphorylated form of the cochaperone Cdc37. Hsp90 does not influence the almost identical c-Src kinase. The structural analysis of Src kinase chimeras that gradually transformed c-Src into v-Src unveiled that Hsp90 dependence correlates with client compactness, folding cooperativity, and lowered energy barriers between different states. These findings establish a new concept for the client specificity of Hsp90. Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including many kinases. The most stringent kinase client is the oncogenic kinase v-Src. To elucidate how Hsp90 chaperones kinases, we reconstituted v-Src kinase chaperoning in vitro and show that its activation is ATP-dependent, with the cochaperone Cdc37 increasing the efficiency. Consistent with in vivo results, we find that Hsp90 does not influence the almost identical c-Src kinase. To explain these findings, we designed Src kinase chimeras that gradually transform c-Src into v-Src and show that their Hsp90 dependence correlates with compactness and folding cooperativity. Molecular dynamics simulations and hydrogen/deuterium exchange of Hsp90-dependent Src kinase variants further reveal increased transitions between inactive and active states and exposure of specific kinase regions. Thus, Hsp90 shifts an ensemble of conformations of v-Src toward high activity states that would otherwise be metastable and poorly populated.
Functional rewiring of brain and spinal cord after injury: the three Rs of neural repair and neurological rehabilitation

Gains in the use of the upper extremities and in walking after brain and spinal cord injury or stroke depend especially upon the effectiveness of spared sensorimotor nodes in the networks for motor control. Biological interventions for neural repair and motor recovery may involve strategies that replace cells or signalling molecules and stimulate the regrowth of axons. The greatest success of these interventions will depend upon the functional incorporation of spared and new cells and their processes into motor networks. The distributed and modular organization of the motor neurons of the cortex and spinal cord offer a substrate that arranges or represents particular patterns of movement, yet is highly adaptable to training. Neurological impairments and related disabilities can be reduced through rehabilitative retraining protocols that engage these critical components of the sensorimotor network to promote use-dependent adaptations and functional rewiring.
Integrating knowledge generation with knowledge diffusion and utilization: a case study analysis of the Consortium for Applied Research and Evaluation in Mental Health.

OBJECTIVE Knowledge diffusion and utilization (KDU) have become a key focus in the health research community because of the limited success to date of research findings to inform health policies, programs and services. Yet, evidence indicates that successful KDU is often predicated on the early involvement of potential knowledge users in the conceptualization and conduct of the research and on the development of a "partnership culture". This study describes the integration of KDU theory with practice via a case study analysis of the Consortium for Applied Research and Evaluation in Mental Health (CAREMH). METHODS This qualitative study, using a single-case design, included a number of data sources: proposals, meeting minutes, presentations, publications, reports and curricula vitae of CAREMH members. RESULTS CAREMH has adopted the following operational strategies to increase KDU capacity: 1) viewing research as a means and not as an end; 2) bringing the university and researcher to the community; 3) using participatory research methods; 4) embracing transdisciplinary research and interactions; and 5) using connectors. Examples of the iterative process between researchers and potential knowledge users in their contribution to knowledge generation, diffusion and utilization are provided. CONCLUSIONS This case study supports the importance of early and ongoing involvement of relevant potential knowledge users in research to enhance its utilization potential. It also highlights the need for re-thinking research funding approaches.
A quick assay for monitoring recombinant hirudin during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II : adaptation of the ecarin clotting time to the act II device.

BACKGROUND Recombinant hirudin is increasingly advocated as a promising alternative anticoagulation for patients with heparin-induced thrombocytopenia type II during cardiopulmonary bypass. This requires monitoring of the ecarin clotting time. No commercial ecarin clotting time assay is available for clinical use. We adapted the ecarin clotting time to the easy-to-handle ACT II device. METHODS Three different concentrations of the ecarin reagent (20, 10, 5 U/mL) were investigated as preliminary studies. Standard calibration curves were constructed for concentrations of recombinant hirudin ranging from 0 to 5 microgram/mL. In vivo samples were collected from patients with heparin-induced thrombocytopenia type II who underwent cardiopulmonary bypass, and the values were compared with the values obtained by the chromogenic method. The final concentration for the assay of 5 IU/mL ecarin was further assessed in vitro for reproducibility and the influence of variations in hematocrit, platelet count, and procoagulants. RESULTS All three concentrations of ecarin revealed linearity to 5 microgram/mL concentrations of recombinant hirudin. The ecarin concentration of 5 U/mL revealed the best correlation (0.87) to the laboratory method, was reproducible over the whole recombinant hirudin range, and was not influenced by the variations in the in vitro setup. CONCLUSIONS The ACT II/ecarin clotting time with an ecarin concentration of 5 U/mL is a simple and reliable assay for monitoring recombinant hirudin during cardiopulmonary bypass. Use of this assay allows a wider use of recombinant hirudin in patients with heparin-induced thrombocytopenia type II during bypass and thereby may contribute to the safer management of these patients.
Climate warming feedback from mountain birch forest expansion: reduced albedo dominates carbon uptake

Expanding high‐elevation and high‐latitude forest has contrasting climate feedbacks through carbon sequestration (cooling) and reduced surface reflectance (warming), which are yet poorly quantified. Here, we present an empirically based projection of mountain birch forest expansion in south‐central Norway under climate change and absence of land use. Climate effects of carbon sequestration and albedo change are compared using four emission metrics. Forest expansion was modeled for a projected 2.6 °C increase in summer temperature in 2100, with associated reduced snow cover. We find that the current (year 2000) forest line of the region is circa 100 m lower than its climatic potential due to land‐use history. In the future scenarios, forest cover increased from 12% to 27% between 2000 and 2100, resulting in a 59% increase in biomass carbon storage and an albedo change from 0.46 to 0.30. Forest expansion in 2100 was behind its climatic potential, forest migration rates being the primary limiting factor. In 2100, the warming caused by lower albedo from expanding forest was 10 to 17 times stronger than the cooling effect from carbon sequestration for all emission metrics considered. Reduced snow cover further exacerbated the net warming feedback. The warming effect is considerably stronger than previously reported for boreal forest cover, because of the typically low biomass density in mountain forests and the large changes in albedo of snow‐covered tundra areas. The positive climate feedback of high‐latitude and high‐elevation expanding forests with seasonal snow cover exceeds those of afforestation at lower elevation, and calls for further attention of both modelers and empiricists. The inclusion and upscaling of these climate feedbacks from mountain forests into global models is warranted to assess the potential global impacts.
Waste Picker Organizations and Their Contribution to the Circular Economy: Two Case Studies from a Global South Perspective

The discussion on the circular economy (CE) has attracted a rising interest within global policy and business as a way of increasing the sustainability of production and consumption. Yet the literature mostly portrays a Global North perspective. There is a diverse spectrum of community-based organizations playing important roles in resource recovery and transformation, particularly, but not only, in Global South countries, providing innovative examples for grassroots involvement in waste management and in the CE. This article proposes to add a Southern lens, situated in the context of waste picker organizations, to the concept of CE. The discursive framework in this article couples ecological economy (EE) with social/solidarity economy (SSE), focusing not only on environmental sustainability but also on social, economic, political and cultural dimensions involved in production, consumption and discard. We acknowledge that grassroots movements contribute to policy making and improve urban waste management systems. The paper outlines two empirical studies (Argentina, Brazil) that illustrate how waste picker organizations perform selective waste collection services, engage with municipalities and industries, and practice the CE. The research reveals that social and political facets need to be added to the debate about the CE, linking environmental management and policy with community development and recognizing waste pickers as protagonists in the CE. Our findings emphasize a need for a change of persisting inequalities in public policy by recognizing the importance of popular waste management praxis and knowledge, ultimately redefining the CE.
Are multidimensional social classifications of areas useful in UK health service research?

OBJECTIVES--To show the advantages and disadvantages of a multi-dimensional small area classification in the analysis of child health data in order to measure social inequalities in health and to identify the types of area that have greater health needs. DESIGN--Health data on children from the district child health information system and a survey of primary school children's height were classified by the census enumeration district of residence using the Super profiles neighbourhood classification. SETTING--County of Northumberland, United Kingdom. SUBJECTS--One cohort comprised 21,702 preschool children age 0-5 years resident in Northumberland, and another cohort 9930 school children aged 5-8.5 years. MAIN OUTCOME MEASURES--Variations between types of area in the proportions of babies with birthweight less than 2.8 kg; births to mothers aged less than 20 years; pertussis immunisation uptake; child health screening uptake; and mean height of school children. RESULTS--Areas with the poorest child health measures were those which were most socially disadvantaged. The most affluent areas tended to have the best measures of health, although rural areas also had good measures. Problems in analysis included examples of the "ecological fallacy", misleading area descriptions, and the identification of the specific factors associated with poor health measures. Advantages included a wider view of social circumstances than simply "deprivation" and the ability to identify characteristic types of areas with increased child health needs. CONCLUSIONS--There is a limited place for multidimensional small area classifications in the analysis of health data for both research and health needs assessment provided the inherent drawbacks of these data are understood in interpreting the results.
Towards understanding the potential of sketching animated visualizations in generative workshops

The research presented in this paper aims at increasing our understanding of how tools to rapidly create and manipulate animations can influence the design process in a positive way. We are especially interested in creative activities that are conducted in groups. We present a case study where a tool for sketching animations was introduced in a game-concept-generation workshop that was conducted by an existing design team at a multinational company. The results show that animations can indeed be used productively for real-time exploration, communication and discussion of a wide variety of ideas. Animations are especially beneficial when the concepts under discussion are highly dynamic. The observations also suggest that working with animations contributes to the group dynamics, as the design collaboration becomes more playful, expressive and fun, in comparison to when people are working only with conventional sketches.
An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice.

1. A detailed compartmental model of a cerebellar Purkinje cell with active dendritic membrane was constructed. The model was based on anatomic reconstructions of single Purkinje cells and included 10 different types of voltage-dependent channels described by Hodgkin-Huxley equations, derived from Purkinje cell-specific voltage-clamp data where available. These channels included a fast and persistent Na+ channel, three voltage-dependent K+ channels, T-type and P-type Ca2+ channels, and two types of Ca(2+)-activated K+ channels. 2. The ionic channels were distributed differentially over three zones of the model, with Na+ channels in the soma, fast K+ channels in the soma and main dendrite, and Ca2+ channels and Ca(2+)-activated K+ channels in the entire dendrite. Channel densities in the model were varied until it could reproduce Purkinje cell responses to current injections in the soma or dendrite, as observed in slice recordings. 3. As in real Purkinje cells, the model generated two types of spiking behavior. In response to small current injections the model fired exclusively fast somatic spikes. These somatic spikes were caused by Na+ channels and repolarized by the delayed rectifier. When higher-amplitude current injections were given, sodium spiking increased in frequency until the model generated large dendritic Ca2+ spikes. Analysis of membrane currents underlying this behavior showed that these Ca2+ spikes were caused by the P-type Ca2+ channel and repolarized by the BK-type Ca(2+)-activated K+ channel. As in pharmacological blocking experiments, removal of Na+ channels abolished the fast spikes and removal of Ca2+ channels removed Ca2+ spiking. 4. In addition to spiking behavior, the model also produced slow plateau potentials in both the dendrite and soma. These longer-duration potentials occurred in response to both short and prolonged current steps. Analysis of the model demonstrated that the plateau potentials in the soma were caused by the window current component of the fast Na+ current, which was much larger than the current through the persistent Na+ channels. Plateau potentials in the dendrite were carried by the same P-type Ca2+ channel that was also responsible for Ca2+ spike generation. The P channel could participate in both model functions because of the low-threshold K2-type Ca(2+)-activated K+ channel, which dynamically changed the threshold for dendritic spike generation through a negative feedback loop with the activation kinetics of the P-type Ca2+ channel. 5. These model responses were robust to changes in the densities of all of the ionic channels. (ABSTRACT TRUNCATED AT 400 WORDS)
Risk Assessment for Power System Operation Planning With High Wind Power Penetration

Integration of wind power generation (WPG) is increasing rapidly worldwide. The variability and uncertainty of wind energy may lead to significant load-generation imbalances resulting in large frequency deviations, hence increasing system operational risks, especially in small and isolated power systems with low inertia and limited capabilities of providing frequency responses. This raises the need for investigating alternatives to current power system operation planning approaches to cope with the uncertain nature of the intermittent generation. This paper presents a risk assessment approach to analyze power system security for operation planning under high penetration of wind power generation. The proposed approach deals with not only steady-state voltage and overload evaluations, but also frequency response adequacy. For fast identification of operational limit violations in the proposed risk assessment method, we develop an analytical procedure for approximating frequency response and assessing the consequences of limit violations without performing dynamic simulations. As a result, the frequency response adequacy assessment can be run simultaneously with the steady-state voltage and overload evaluations. The proposed risk assessment approach is illustrated via its application to a model of a power system with high wind power penetration.
Structural and biochemical basis for the UVB‐induced alterations in epidermal barrier function

Ultraviolet light (UVR) induces a myriad of cutaneous changes, including delayed disruption of the permeability barrier with higher doses. To investigate the basis for the UVB‐induced barrier alteration, we assessed the epidermal lamellar body secretory system at various time points before and after barrier disruption with a single high dose of UVB (7.5 MED) to murine epidermis. Morphological data were correlated with changes in epidermal proliferation and lipid synthesis, indicative of lamellar body generation. Twenty‐four hours following UVB, the stratum corneum (SC) is normal, but a layer of abnormal, vacuolated, and lamellar body (LB)‐deficient cells is present, immediately beneath the stratum granulosum (SG)/SC interface. Immediately subjacent to this band of damaged cells, normal keratinocytes that contain intact LBs are present. By 72 h, concomitant with the appearance of a barrier abnormality, extensively damaged cells persist at the SC/SG interface, and abnormal lamellar membrane structures appear in the lower SC. Upper stratum spinosum (SS) and lower SG cells appear normal, with increased numbers of LBs. A barrier abnormality is still present at 96 h, in association with membrane abnormalities in the lower SC interstices, but up to four normal‐appearing, subjacent SG cell layers are present. By 120 h, accelerated LB formation and precocious LB extrusion occur throughout the thickened SG; normal lamellar membranes are present in the lower SC; and barrier recovery is almost complete. Whereas, epidermal synthesis of the major barrier lipid species (i.e., cholesterol, fatty acids, and ceramides, including acylceramides) is reduced or unchanged at 24 and 48 h, it increases significantly 72 h after exposure to UVB. Therefore, the delayed disruption of the permeability barrier following acute UVB exposure results from the arrival of a band of lamellar body‐incompetent (i.e., damaged) cells at the SG/SC interface. The subsequent, rapid recovery of the barrier, in turn, results from compensatory hyperplasia of subjacent, undamaged SS/SG cells, generating increased numbers and contents of LB. These results underscore the critical role of the stratum compactum in mediating barrier function, and suggest that beneficial therapeutic effects of UV exposure may be due to enhanced lipid production and barrier regeneration.