Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Oleic Acid on Triglycerides (TG) Accumulation and mRNA Level of PPARalpha and PPARgamma in Goose Primary Hepatocytes

In this study, the effect of oleic oil on cytoactive, triglycerides (TG) accumulation, lipids drop and mRNA expression of peroxisome proliferatoractivated receptor (PPAR ) and peroxisome proliferator-activated receptor PPAR was measured in primary goose hepatocytes. Results were as follows: 1.5 mmol/L oleic oil had an inhibiting effect on the cell viability; oleic oil could induce the goose hepatocytic steatosis and the increase of TG content and lipid droplet. Oleic oil all could increase the mRNA level of PPAR ; 0.5 mmol/L oleic oil could increase the mRNA level of PPAR , but 1.0 mmol/L and 1.5 mmol/L oleic oil had no evident effect. Conclusion: in the model of oleic oil induced goose hepatocytic steatosis, the change of PPAR and PPAR expression level is favor of the balance of lipids metabolism in hepatocytes, and this may be related to the capability of keeping normal physiological function in the hepatic steatosis in waterfowl. Keywords-Goose; oleic oil;PPARs;TG
Changes in polyamines content associated with zygotic embryogenesis in the Brazilian pine, Araucaria angustifolia (Bert.) O. Ktze.

Changes in the polyamine content were analyzed in different embryo developmental stages and tissues during seed development in the conifer Araucaria angustifolia (Bert.) O. Ktze. Free polyamine contents varied according to the tissue and stage of embryo development, the highest levels occurring in the embryonic axis at the early stages, when putrescine and spermidine were most abundant. The levels of spermidine were higher from the stage where cotyledons arise, whereas putrescine decreases. The putrescine/spermine+spermidine ratio was higher during the initial phases of seed development, corresponding to cell multiplication and elongation, with a decrease in the final stages, corresponding to stabilization of the dry matter content.
Systematic Review and Meta-Analysis of the Epidemiology of Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates

Background Vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) are associated with vancomycin treatment failure, and are becoming an increasing public health problem. Therefore, we undertook this study of 91 published studies and made subgroup comparisons of hVISA/VISA incidence in different study years, locations, and types of clinical samples. We also analyzed the genetic backgrounds of these strains. Methods A systematic literature review of relevant articles published in PubMed and EMBASE from January 1997 to August 2014 was conducted. We selected and assessed journal articles reporting the prevalence rates of hVISA/VISA. Results The pooled prevalence of hVISA was 6.05% in 99,042 methicillin-resistant S. aureus (MRSA) strains and that of VISA was 3.01% in 68,792 MRSA strains. The prevalence of hVISA was 4.68% before 2006, 5.38% in 2006–2009, and 7.01% in 2010–2014. VISA prevalence was 2.05%, 2.63%, and 7.93%, respectively. In a subgroup analysis of different isolation locations, the prevalence of hVISA strains was 6.81% in Asia and 5.60% in Europe/America, and that of VISA was 3.42% and 2.75%, respectively. The frequencies of hVISA isolated from blood culture samples and from all clinical samples were 9.81% and 4.68%, respectively, and those of VISA were 2.00% and 3.07%, respectively. The most prevalent genotype was staphylococcal cassette chromosome mec (SCCmec) II, which accounted for 48.16% and 37.74% of hVISA and VISA, respectively. Sequence Type (ST) 239 was most prevalent. Conclusion The prevalence of hVISA/VISA has been increasing in recent years, but has been grossly underestimated. Its incidence is higher in Asia than in Europe/America. hVISA is isolated from blood culture samples more often than from other samples. These strains are highly prevalent in epidemic MRSA strains. This study clarifies the epidemiology of hVISA/VISA and indicates that the detection of these strains and the control of nosocomial infections must be strengthened.
Atomic force microscope anodization lithography using pulsed bias voltage synchronized with resonance frequency of cantilever

An applied bias voltage between the atomic force microscope tip and the substrate is one of the important factors related to the growth of oxide patterns. A pulse modulator was used to apply a pulsed bias voltage that synchronizes with the resonance frequency of the cantilever between the tip and the substrate in tapping mode. The height of the protruded oxide structure was increased for short duration times of the pulsed bias due to the reduction of built-up space charge in oxide. The aspect ratio of patterns using pulsed bias voltage was about two times higher than that using continuous bias voltage. This study revealed that the pulsed bias has an advantage for obtaining a higher aspect ratio pattern than the continuous bias by reducing the effect of space charge in oxide.
Performance compétente : Relations avec valeurs, pratiques et identité dans le service de police

L'objectif general de cette these est d'identifier l'influence des manifestations de la culture de l'organisation, en matiere de valeurs et de pratiques organisationnelles, ainsi que de l'identite professionnelle et organisationnelle sur la performance professionnelle par les competences, c'est-a-dire la performance competente, au sein de la police. 916 policiers militaires du District Federal de tous les niveaux hierarchiques ont participe a cette recherche. Des analyses factorielles exploratoires et confirmatoires ont ete utilisees pour verifier les evidences de la validite des mesures des constructions qui composent le modele theorique. Les resultats trouves suggerent que les variables antecedentes (valeurs organisationnelles, pratiques organisationnelles, identite professionnelle et identite organisationnelle) permettent de faire des predictions quant a la performance professionnelle. Aussi bien l'identite organisationnelle que l'identite professionnelle ont permis de faire une mediation (mediation simple et en chaine) entre les dimensions sous-jacentes aux valeurs et aux pratiques organisationnelles et la performance au travail. Les pratiques organisationnelles ont plus de pouvoir de prediction que les types de motivations par rapport a la performance professionnelle. Le test des modeles generaux et des modeles detailles (modeles concurrents) a demontre que les constructions du modele etaient stables et invariantes, ce qui permet leur utilisation dans differents contextes. Enfin, des limitations de recherche ont ete montrees, leurs implications sont d'ordre theorique, methodologique et de gestion, ce qui demande la mise en place de nouvelles recherches.
Vertical handoff modeling and simulation in VANET scenarios

In Vehicular ad hoc network (VANET), vehicular users (VUs) are capable of connecting to different access networks for interacting both safety related information and user application related information. In the overlapped area of heterogeneous networks, VUs are allowed to perform vertical handoff between various access networks. As the performance of vertical handoff plays an important role in guaranteeing user quality of service (QoS) and achieving system performance enhancement, it should be examined and evaluated thoroughly. In this paper, vertical handoff performance of VUs in a VANET scenario consisting of heterogeneously integrated universal mobile telecommunications system (UMTS) and wireless local area network (WLAN) is evaluated based on network simulator 2 (NS2). Multi-mode nodes, which are capable of accessing both networks and a media independent handover (MIH)-based vertical handoff scheme are implemented in NS2. The impacts of user velocity, the strength of traffic load and the type of handoff mechanisms on the communication performance of VUs, i.e., throughput, handoff latency and packet loss are examined.
Considering behavior of sender in spam mail detection

Recently, the number of spam mails is exponentially growing. It affects the costs of organizations and annoying the e-mail recipient. Spammers always try to find the way to avoid filtering out from the email system. At the same time, as an email recipient or network system/administrator, we try to have an effective spam mail filtering technique to catch the spam mails. The problems of spam mail filtering are that each user has different perspective toward spam mails; so there are many types of spam mails, while the challenge is how to detect the various types and forms of spam mails. In this paper, behaviors of spammers are used to customize the filtering rule. The information from the spam messages also can be used to filter spam mails and it can give higher accuracy than the keyword-based method does. We propose a spam classification approach using Random Forest algorithm. Spam Assassin Corpus is selected as a database for classification. It consists of 6,047 email messages, where 4,150 of them are the legitimate messages and the other 1,897 messages are the spam mails.
Skin-Sparing Mastectomy and Immediate Tissue Expander Breast Reconstruction in Patients With Macromastia Using the Passot Breast Reduction Pattern

AbstractSkin-sparing mastectomy (SSM) with immediate tissue expander reconstruction poses a challenge in the patient with macromastia or excessive ptosis. Skin reduction via the Wise pattern has been described but is associated with high rates of skin necrosis. The study group consisted of 43 women with grade 2 or 3 ptosis who underwent SSM and immediate reconstruction with tissue expanders, using the Passot (horizontal) skin reduction pattern. Age ranged from 31 to 67 years (mean, 51 years). The endpoints measured were time to final expansion, mastectomy skin flap necrosis, infectious complications, and total complications. Thirty reconstructions were bilateral and 13 were unilateral (73 breasts total). Follow-up ranged from 6 to 55 months (mean, 20). Common comorbid conditions included hypertension (n = 16), obesity (n = 22), and smoking (n = 9). The mean body mass index was 30.6 (range, 19.4–58.6). Twenty-one patients underwent chemotherapy; 12 received radiation. The mean initial fill was 196 mL (range, 0–420 mL), and the mean time to final expansion was 84 days (range, 28–225 days). Five patients did not complete the reconstruction, 2 because of cancer recurrence and 3 because of infection. There were 3 cases of mastectomy flap necrosis occurring after tissue expander placement (7%). There were 7 infectious complications (16%). The use of a horizontal breast reduction pattern at the time of expander placement produces consistently good esthetic outcomes and a low rate of skin necrosis, and it should be considered as an option in patients with macromastia or ptosis undergoing SSM and immediate reconstruction.
A Systems Theory of Religion

A Systems Theory of Religion, still unfinished at Niklas Luhmann's death in 1998, was first published in German two years later thanks to the editorial work of Andre Kieserling. One of Luhmann's most important projects, it exemplifies his later work while redefining the subject matter of the sociology of religion. Religion, for Luhmann, is one of the many functionally differentiated social systems that make up modern society. All such subsystems consist entirely of communications and all are "autopoietic," which is to say, self-organizing and self-generating. Here, Luhmann explains how religion provides a code for coping with the complexity, opacity, and uncontrollability of our world. Religion functions to make definite the indefinite, to reconcile the immanent and the transcendent. Synthesizing approaches as disparate as the philosophy of language, historical linguistics, deconstruction, and formal systems theory/cybernetics, A Systems Theory of Religion takes on important topics that range from religion's meaning and evolution to secularization, turning decades of sociological assumptions on their head. It provides us with a fresh vocabulary and a fresh philosophical and sociological approach to one of society's most fundamental phenomena.
Phagocytosis of latex beads by Acanthameba

Electron microscopic studies confirm and extend the conclusions derived previously from a quantitative biochemical study of the phagocytosis of polystyrene and polyvinyltoluene latex beads by Acanthamoeba (1). Latex beads 1.305, 1.90, and 2.68 pA in diameter are ingested individually, with each bead tightly surrounded by a membrane derived from the plasma membrane. Latex beads 0.557, 0.264, 0.126, and 0.088 p in diameter are accumulated at the surface of the ameba and then phagocytosed, with many beads tightly packed within one membrane-bounded vesicle.
Divergence of epidermal growth factor-transforming growth factorß signaling in embryonic orofacial tissue

SummaryThe epidermal growth factor (EGF) and transforming growth factor β (TGFβ) families of signaling molecules play a major role in growth and development of embryos. Abrogation of either signaling pathway results in defects in embryogenesis, including cleft palate. In the developing palate, both EGF and TGFβ regulate cellular proliferation, extracellular matrix synthesis, and cellular differentiation but often in an opposing manner. Evidence from various adult cell types suggests the existence of cross talk between the EGF and TGFβ signaling pathways, although it is unclear whether such cross talk exists in murine embryonic maxillary mesenchymal cells, from which the developing palate is derived. In this study, embryonic maxillary mesenchymal cells in culture were treated with EGF and TGFβ, either singly or in combination, and the cells were subsequently examined for signaling interactions between these two pathways. Immunoblot analyses of nuclear extracts of embryonic maxillary mesenchymal cells revealed that TGFβ-induced nuclear translocation of Smad 2 and Smad 3 proteins was not affected by EGF. Conversely, immunoblot analyses of whole-cell extracts of these cells indicated that EGF-induced phosphorylation of extracellular signal-regulated kinase proteins, ERK1 and ERK2, was not affected by TGFβ. Expression of a transfected luciferase reporter gene driven by a promoter with Smad binding elements was induced by TGFβ in these cells but was not affected by EGF. Last, TGFβ was found to induce expression of the endogenous gelatinase B gene in embryonic maxillary mesenchymal cells; however, this effect was independent of any interaction of EGF. Collectively, data from this study suggest that the EGF and TGFβ signal transduction pathways do not converge in murine embryonic maxillary mesenchymal cells.
How should we be searching for genes for common epilepsy? A critique and a prescription

Despite enormous data collection and analysis efforts, the genetic influences on common epilepsies remain mostly unknown. We propose that reasons for the lack of progress can be traced to three factors: (1) A reluctance to consider fine‐grained phenotype definitions based on extensive and carefully collected clinical data; (2) the pursuit of genetic analysis methods that are popular but poorly conceived and are inadequate to the task of resolving the problems inherent in common disease studies; (3) preconceived ideas about the genetic mechanisms that cause epilepsy (which we have discussed elsewhere). We propose a paradigm for finding epilepsy‐related loci and alleles that has proven successful in other common diseases.
THE OCCURRENCE OF POLYGLYCEROPHOSPHATE AS AN ANTIGENIC COMPONENT OF VARIOUS GRAM-POSITIVE BACTERIAL SPECIES

A bacterial substance has been described which gives a precipitin reaction with certain antisera to Group A streptococci. The precipitating antigen is present in various Gram-positive bacteria, including most hemolytic streptococci, staphylococci, and aerobic sporulating bacilli. It is not present in any of the Gram-negative species examined or in pneumococci, clostridia, or corynebacteria. Analysis of purified preparations obtained from Group A streptococci indicates that the antigen is a simple polymer of glycerophosphate. The identification has been confirmed by immunochemical studies, including precipitin tests and specific inhibition with synthetic polyglycerophosphates. In addition, the infrared spectra of bacterial and synthetic polyglycerophosphate are shown to be closely similar. Immunochemical analysis suggests that the amount of polyglycerophosphate present in Group A streptococci and staphylococci is approximately 1 per cent of the dry weight of the cells. The cellular localization and function of the polyglycerophosphate have not been established.
Un algoritmo lingüístico-estadístico para resumen automático de textos especializados

Resumen En este trabajo se presenta un nuevo algoritmo de resumen automatico de textos especializados, en concreto del dominio medico , que auna estrategias linguisticas y estadisticas. La novedad del articulo radica en la correcta combinacion de dichas estrategias de cara a demostrar que los sistemas hibridos pueden obtener mejores resultados que los sistemas estadisticos o linguisticos por si solos. Se aplica el algoritmo sobre un corpus de textos medicos y se evalua siguiendo el protocolo de NIST y utilizando el paquete Rouge. Se obtienen excelentes resultados en comparacion con otros sistemas y se observa que los resumenes realizados son muy similares a los de los especialistas del dominio. 1. Introduccion El resumen automatico es actualmente un tema de investigacion muy relevante. La investigacion en esta area se inicio en los anos sesenta, emple-ando tecnicas basadas en frecuencias de palabras (Luhn, 1959) o frases clave (Edmundson, 1969). Con el tiempo, estas tecnicas han ido evolucio-nando y volviendose mas complejas. Podemos ha-cer una division general de estas tecnicas en dos grupos principales: las tecnicas estadisticas y las tecnicas linguisticas. En el primer grupo 1 , encon-tramos, entre otros, trabajos que emplean mo-delos bayesianos (Kupiec, Pedersen, and Chen, 1995), la Maximal Marginal Relevance (Golds-tein et al., 1999), tecnicas de clustering (Ra-dev. En el segundo grupo, destacamos trabajos que explotan las posiciones textuales (Brandow, Mitze, and Rau, 1995; Lin and Hovy, 1997), la estructura del discurso (Ono, Sumita, 1 No pretendemos hacer aqui una revision exhaustiva del estado de la cuestion en resumen automatico. Para mas informacion sobre tecnicas y/o sistemas de resumen remitimos a los trabajos de (Sparck Jones, 2007; Mani, 2001; Mani and Maybury, 1999).
Innovation Contests - Where are we?

Innovation contests in their basic structure have a long-standing tradition and can be attributed to continuously gain in importance as a corporate practice. A deep understanding of this online instrument, however, is still lacking. Contrary to other methods used to realize open innovation, research in the field of online innovation contests displays a growing, but only rudimentarily intertwined body of publications. This paper provides the essential systematization of the field, integrating both, academic knowledge and business deployment. Juxtaposing 33 relevant journal and conference publications with empirical basis and an analysis of 57 real-world innovation contests, we highlight interesting disruptions and distill six pathways for future research. These cover the optimal degree of elaboration, the interplay of competition and community, the importance of community applications, the trajectory towards open evaluation, and the identification of additional design elements.
Instanton rate constant calculations close to and above the crossover temperature

Canonical instanton theory is known to overestimate the rate constant close to a system‐dependent crossover temperature and is inapplicable above that temperature. We compare the accuracy of the reaction rate constants calculated using recent semi‐classical rate expressions to those from canonical instanton theory. We show that rate constants calculated purely from solving the stability matrix for the action in degrees of freedom orthogonal to the instanton path is not applicable at arbitrarily low temperatures and use two methods to overcome this. Furthermore, as a by‐product of the developed methods, we derive a simple correction to canonical instanton theory that can alleviate this known overestimation of rate constants close to the crossover temperature. The combined methods accurately reproduce the rate constants of the canonical theory along the whole temperature range without the spurious overestimation near the crossover temperature. We calculate and compare rate constants on three different reactions: H in the Müller–Brown potential, methylhydroxycarbene → acetaldehyde and H2 + OH → H + H2O. © 2017 Wiley Periodicals, Inc.
Knowledge Search Abroad and Innovation Performance: An Empirical Study of Chinese High-Tech Firms

Under the background of low income of high-tech industry based on the mode of FDI, and Chinese firms gradually lose out in the competition of the high-tech product export, we construct the research model of the relationship knowledge search of R&D teams of high-tech firms, and innovation performance. Through the empirical study, we find that our R&D teams of high-tech firms are insufficient of oversea learning, and there are two different but opposite knowledge search strategies. Based on the strategy of searching deep knowledge abroad, firms can make a follow and imitational innovation mode, and from the strategy of searching wide knowledge abroad, firms can make an combining innovation and domestic market leader mode.
Finding lists of people on the web

Among the vast amounts of personal information published on the World Wide Web ("Web") and indexed by search engines are lists of names of people. Examples include employees at companies, students enrolled in universities, officers in the military, law enforcement personnel, members of social organizations, and lists of acquaintances. Knowing who works where, attends what, or affiliates with whom provides strategic knowledge to competitors, marketers, and government surveillance efforts. However, finding online rosters of people does not lend itself to keyword lookup on search engines because the keywords tend to be common expressions such as "employees" or "students. " A typical search often retrieves hundreds of Web pages requiring many hours of human inspection to locate a page containing a list of names. As a result, people may falsely believe online rosters provide more privacy than they do. This paper presents RosterFinder, a simple algorithm for locating Web pages that consist predominately of a list of names. The specific names are not known beforehand. RosterFinder works by identifying rosters from candidate Web pages based on the ratio of distinct known names to distinct words appearing in the page. Accurate classification by RosterFinder depends on the set of names used. Results are reported on real Web pages using: (1) dictionary lookup employing a limited set of known names; and, (2) dictionary lookup on utilizing an extensive set of known names. Privacy implications are discussed using the example of FERPA and online student rosters.