Miracle-dz/UniFAR-FTUs huggingface dataset:
A new iterative algorithm training SVM

Based on the geometric interpretation of the support vector machine (SVM), a new feasible direction (NFD) algorithm is first proposed as a generalization of Franc and Hlaváĉ’s SK algorithm in this study. In the new algorithm, two vertices of the training sets are selected to update the current solution per iteration for the separable problem, while only one of them is used in the SK algorithm. Similar to the SK and Keerthi et al.’s nearest points algorithm (NPA), the proposed NFD can solve the inseparable problem with L 2 cost function. Furthermore, based on a geometric interpretation of ν-SVM and the definition of the reduced convex hull, the proposed algorithm extends to train the ν-SVM with commonly L 1 cost function for the inseparable problem. The convergence property of the algorithm is studied from the theoretical viewpoint. Computational experiments suggest that our algorithms are competitive with other SVM algorithms including SK, NPA, Tao et al.’s generalized SK and SMO. It was observed that the number of iterations and the training time are reduced in many cases.
Text mining and social network analysis on computer science and engineering theses in Turkey

In this study, we examined 6,834 master's and PhD theses conducted on computer science and engineering between 1994 and 2013 in Turkey. Thesis data were compiled from the YÖK national thesis database web portal. We used text mining techniques to extract research concepts and their co-occurrence data from graduate thesis abstracts. Then, we applied social network analysis techniques on the concept co-occurrence networks to visually explore core research concepts, and connections and relationships among them. We showed that text mining and social network analysis techniques together were very effective for knowledge discovery in scientific documents in computer science and engineering domain.
Balancing emotional processing with ongoing cognitive activity: the effects of task modality on intrusions and rumination

In the present paper we aimed to show that competition for resources between post-emotional processes and the execution of a cognitive task will result in two possible effects: (1) an impairment of the cognitive task in the short run and (2) an elongation of intrusions and rumination in the long run. The outcome of this competition is influenced by the interaction of the modality (verbal vs. visuospatial) of cognitive tasks run in the aftermath of an emotional experience and the nature (verbal vs. visuospatial) of the same experience. Non-clinical participants were given a working memory task (OSPAN vs. an analog Visual task) before and after the presentation of negative vs. neutral material (a novel excerpt in Experiment 1 and a video clip in Experiment 2). Intrusions and rumination were measured after a 24-h delay. Rumination was also assessed immediately after the experimental induction. Results showed that exposure to verbal negative material impaired verbal performance (Experiment 1); by contrast, exposure to visual negative material impaired both verbal and visuospatial performance (Experiment 2). Intrusions were only affected by the emotional valence of the original experience, while performing a visuospatial task resulted in enhanced rumination only after exposure to verbal emotional material. The findings of both experiments suggest that emotional processing spreads over time in balance with ongoing cognitive activities, and, in such a balance, the visuospatial processing mode tends to prevail over verbal engagements.
Unconventional Recombination in the Mating Type Locus of Heterothallic Apple Canker Pathogen Valsa mali

Sexual reproduction in filamentous ascomycetes is controlled by the mating type (MAT) locus, including two idiomorphs MAT1-1 and MAT1-2. Understanding the MAT locus can provide clues for unveiling the sexual development and virulence factors for fungal pathogens. The genus Valsa (Sordariomycetes, Diaporthales) contains many tree pathogens responsible for destructive canker diseases. The sexual stage of these ascomycetes is occasionally observed in nature, and no MAT locus has been reported to date. Here, we identified the MAT locus of the apple canker pathogen Valsa mali, which causes extensive damage, and even death, to trees. V. mali is heterothallic in that each isolate carries either the MAT1-1 or MAT1-2 idiomorph. However, the MAT structure is distinct from that of many other heterothallic fungi in the Sordariomycetes. Two flanking genes, COX13 and APN2, were coopted into the MAT locus, possibly by intrachromosomal rearrangement. After the acquisition of foreign genes, unequal recombination occurred between MAT1-1/2 idiomorphs, resulting in a reverse insertion in the MAT1-2 idiomorph. Evolutionary analysis showed that the three complete MAT1-1-2, COX13, and APN2 genes in this region diverged independently due to different selection pressure. Null hypothesis tests of a 1:1 MAT ratio of 86 V. mali isolates from four different provinces showed a relatively balanced distribution of the two idiomorphs in the fields. These results provide insights into the evolution of the mating systems in Sordariomycetes.
Evaluating Language Resources for CLEF 2007

This is a report on our evaluations of using some language resources for the Indonesian-English bilingual task of the 2007 Cross-Language Evaluation Forum (CLEF). We chose to translate an Indonesian query set into English using machine translation technique, transitive translation technique, and parallel corpus technique. We also made an attempt to improve the retrieval effectiveness using a query expansion technique. The result shows that the best result was achieved by combining the machine translation technique and the query expansion technique.
Hippocampal Volume and Shape Analysis in an Older Adult Population

This report presents a manual segmentation protocol for the hippocampus that yields a reliable and comprehensive measure of volume, a goal that has proven difficult with prior methods. Key features of this method include alignment of the images in the long axis of the hippocampus and the use of a three-dimensional image visualization function to disambiguate anterior and posterior hippocampal boundaries. We describe procedures for hippocampal volumetry and shape analysis, provide inter- and intra-rater reliability data, and examine correlates of hippocampal volume in a sample of healthy older adults. Participants were 40 healthy older adults with no significant cognitive complaints, no evidence of mild cognitive impairment or dementia, and no other neurological or psychiatric disorder. Using a 1.5 T GE Signa scanner, three-dimensional spoiled gradient recalled acquisition in a steady state (SPGR) sequences were acquired for each participant. Images were resampled into 1 mm isotropic voxels, and realigned along the interhemispheric fissure in the axial and coronal planes, and the long axis of the hippocampus in the sagittal plane. Using the BRAINS program (Andreasen et al., 1993), the boundaries of the hippocampus were visualized in the three orthogonal views, and boundary demarcations were transferred to the coronal plane for tracing. Hippocampal volumes were calculated after adjusting for intracranial volume (ICV). Intra- and inter-rater reliabilities, measured using the intraclass correlation coefficient, exceeded . 94 for both the left and right hippocampus. Total ICV-adjusted volumes were 3.48 (±0.43) cc for the left hippocampus and 3.68 (±0.42) for the right. There were no significant hippocampal volume differences between males and females (p > .05). In addition to providing a comprehensive volumetric measurement of the hippocampus, the refinements included in our tracing protocol permit analysis of changes in hippocampal shape. Shape analyses may yield novel information about structural brain changes in aging and dementia that are not reflected in volumetric measurements alone. These and other novel directions in research on hippocampal function and dysfunction will be facilitated by the use of reliable, comprehensive, and consistent segmentation and measurement methods.
The C-terminal silencing domain of Rap1p is essential for the repression of ribosomal protein genes in response to a defect in the secretory pathway.

We have previously shown that a functional secretory pathway is essential for continued ribosome synthesis in Saccharomyces cerevisiae. When a temperature-sensitive mutant defective in the secretory pathway is transferred to the non-permissive temperature, transcription of both rRNA genes and ribosomal protein genes is nearly abolished. In order to define the cis -acting element(s) of ribosomal protein genes sensitive to a defect in the secretory pathway, we have constructed a series of fusion genes containing the CYH2 promoter region, with various deletions, fused to lacZ. Each fusion gene for which transcription is detected is subject to the repression. Rap1p is the transcriptional activator for most ribosomal protein genes, as well as having an important role in silencing in the vicinity of telomeres and at the silent mating-type loci. To assess its role in the repression of transcription by the defect in the secretory pathway, we have introduced rap1 mutations. The replacement of wild-type Rap1p by Rap1p truncated at the C-terminal region caused substantial attenuation of the repression. Furthermore, we have demonstrated that the Rap1p-truncation affects the repression of TCM1 , encoding ribosomal protein L3, which has no Rap1p-binding site in its upstream regulatory region. These results suggest that the repression of transcription of ribosomal protein genes by a secretory defect is mediated through Rap1p, but does not require a Rap1p-binding site within the UAS.
Bmc Molecular Biology

An in vivo analysis of the localisation and interactions of human p66 DNA polymerase δ subunit Abstract Background: DNA polymerase δ is essential for eukaryotic DNA replication and also plays a role in DNA repair. The processivity of this polymerase complex is dependent upon its interaction with the sliding clamp PCNA and the polymerase-PCNA interaction is largely mediated through the p66 polymerase subunit. We have analysed the interactions of the human p66 DNA polymerase δ subunit with PCNA and with components of the DNA polymerase δ complex in vivo.
A biologically inspired QoS routing algorithm for mobile ad hoc networks

This paper presents EARA-QoS, a improved version of swarm-intelligence inspired ad hoc routing algorithm EARA introduced in (Z. Liu et al., 2004). In this algorithm, we use the principle of swarm intelligence to evolutionally maintain routing information. The biological concept of stigmergy is used to reduce the amount of control traffic. A light-weight QoS scheme is proposed to provide service-classified traffic control. The simulation results show that this novel routing algorithm performs well in a variety of network conditions.
Comparison of nonlocal means despeckling based on stochastic measures

This work presents the use of stochastic measures of similarities as features with statistical significance for the design of despeckling nonlocal means filters. Assuming that the observations follow a Gamma model with two parameters (mean and number of looks), patches are compared by means of the Kullback-Leibler and Hellinger distances, and by their Shannon entropies. A convolution mask is formed using the p-values of tests that verify if the patches come from the same distribution. The filter performances are assessed using well-known phantoms, three measures of quality, and a Monte Carlo experiment with several factors. The proposed filters are contrasted with the Refined Lee and NL-SAR filters.
Development of a low cost optical tilt sensor

The paper deals with the theory, design, fabrication and test results of a Fiber optic tilt sensor. The sensor is based upon the modulation of light intensity with the change in the level of Mercury (Hg) surface with tilt. 650 nm light-emitting diode (LED) is used as light source and the reflected light is detected by light dependant resistor (LDR). The output of the receiver circuit is directly proportional to the tilt angle. The sensitivity of the two probe sensor is 0.013 V mrad−1 and the maximum range covered is 53.4 mrad. The sources of error and their minimization have been discussed.
Incentive Contracts for Road Construction to Reduce Greenhouse Gas Emissions

Road constructions play a significant role in greenhouse gas (GHG) release into the atmosphere due to a large amount of materials consumption. To reduce emission has an effect on project costs. This research proposes an incentive measure named the Construction-Emission-Punishment (CEP) bidding method which offers emission reduction options and incentives for participating bidders. An equivalent bid price and a financial penalty will be specified in the construction contract as a part of this method. This penalty is applied when there is a failure to comply with binding obligations. The results show that the rates of the emission deduction from the six reduction options account for 0.115%-2.768% of the project cost. The case study also shows that a bidder who receives some emission deductions can be the winner. The effectiveness of the CEP method depends on the bid price gaps among the bidders and the emission deduction from the selected options.
Analytical Chatter Stability Prediction for Irregular Types of Milling Tools

High productivity, low cost and high profits in machining processes is important aspects in aerospace, automotive and tool/die metal manufacturing industries. However, the dynamic deflection of tool and work piece systems generates unstable cutting forces when machining with high material removal rate. The main focus of this paper is the study of variable tool geometries effect on chatter stability. A semi discretization method (SDM) was utilized to predict numerical chatter using variable helix, pitch and variable helix and pitch tools effect at high radial immersion. The results showed that variable helix and variable pitch milling tools exhibit better unstable behavior at 25 percent radial immersion.
Towards a Multidimensional Semantics of Discourse Markers in Spoken Dialogue

The literature contains a wealth of theoretical and empirical analyses of discourse marker functions in human communication. Some of these studies address the phenomenon that discourse markers are often multifunctional in a given context, but do not study this in systematic and formal ways. In this paper we show that the use of multiple dimensions in distinguishing and annotating semantic units supports a more accurate analysis of the meaning of discourse markers. We present an empirically-based analysis of the semantic functions of discourse markers in dialogue. We demonstrate that the multiple functions, which a discourse marker may have, are automatically recognizable from utterance surface-features using machine-learning techniques.
OpenAirInterface: A Flexible Platform for 5G Research

Driven by the need to cope with exponentially growing mobile data traffic and to support new traffic types from massive numbers of machine-type devices, academia and industry are thinking beyond the current generation of mobile cellular networks to chalk a path towards fifth generation (5G) mobile networks. Several new approaches and technologies are being considered as potential elements making up such a future mobile network, including cloud RANs, application of SDN principles, exploiting new and unused portions of spectrum, use of massive MIMO and full-duplex communications. Research on these technologies requires realistic and flexible experimentation platforms that offer a wide range of experimentation modes from real-world experimentation to controlled and scalable evaluations while at the same time retaining backward compatibility with current generation systems. Towards this end, we present OpenAirInterface (OAI) as a suitably flexible platform. In addition, we discuss the use of OAI in the context of several widely mentioned 5G research directions.
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis. Antifolate methotrexate (MTX), a drug commonly used in chemotherapy of several types of cancer, is a strong inhibitor of folate metabolism. Here we investigated whether this drug targets CerS6. We observed that CerS6 protein was markedly elevated in several cancer cell lines treated with MTX. In agreement with the enzyme elevation, its product C16-ceramide was also strongly elevated, so as several other ceramide species. The increase in C16-ceramide, however, was eliminated in MTX-treated cells lacking CerS6 through siRNA silencing, while the increase in other ceramides sustained. Furthermore, the siRNA silencing of CerS6 robustly protected A549 lung adenocarcinoma cells from MTX toxicity, while the silencing of another ceramide synthase, CerS4, which was also responsive to folate stress in our previous study, did not interfere with the MTX effect. The rescue effect of CerS6 silencing upon MTX treatment was further confirmed in HCT116 and HepG2 cell lines. Interestingly, CerS6 itself, but not CerS4, induced strong antiproliferative effect in several cancer cell lines if elevated by transient transfection. The effect of MTX on CerS6 elevation was likely p53 dependent, which is in agreement with the hypothesis that the protein is a transcriptional target of p53. In line with this notion, lometrexol, the antifolate inducing cytotoxicity through the p53-independent mechanism, did not affect CerS6 levels. We have also found that MTX induces the formation of ER aggregates, enriched with CerS6 protein. We further demonstrated that such aggregation requires CerS6 and suggests that it is an indication of ER stress. Overall, our study identified CerS6 and ceramide pathways as a novel MTX target.
Perceived Mental Stress and Mortality From Cardiovascular Disease Among Japanese Men and Women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)

Background—Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results—From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95% CI 1.52 to 3.31, P <0.001) for total stroke, 2.28 (95% CI 1.17 to 4.43, P =0.02) for CHD, and 1.64 (95% CI 1.25 to 2.16, P <0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions—Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.
Fixation-Related fMRI Analysis in the Domain of Reading Research: Using Self-Paced Eye Movements as Markers for Hemodynamic Brain Responses During Visual Letter String Processing

The present study investigated the feasibility of using self-paced eye movements during reading (measured by an eye tracker) as markers for calculating hemodynamic brain responses measured by functional magnetic resonance imaging (fMRI). Specifically, we were interested in whether the fixation-related fMRI analysis approach was sensitive enough to detect activation differences between reading material (words and pseudowords) and nonreading material (line and unfamiliar Hebrew strings). Reliable reading-related activation was identified in left hemisphere superior temporal, middle temporal, and occipito-temporal regions including the visual word form area (VWFA). The results of the present study are encouraging insofar as fixation-related analysis could be used in future fMRI studies to clarify some of the inconsistent findings in the literature regarding the VWFA. Our study is the first step in investigating specific visual word recognition processes during self-paced natural sentence reading via simultaneous eye tracking and fMRI, thus aiming at an ecologically valid measurement of reading processes. We provided the proof of concept and methodological framework for the analysis of fixation-related fMRI activation in the domain of reading research.
WSJM, a simple chemically defined medium for growth of Neisseria gonorrhoeae

The growth requirements of 135 clinical isolates of Neisseria gonorrhoeae and six American Type Culture Collection reference strains were examined by using a simple chemically defined medium known as Wong-Shockley-Johnston medium, WSJM. The simple liquid medium supported growth of gonococci from an inoculum of 2 X 10(6) colony-forming units ml-1 and yielded 10(10) colony-forming units ml-1 in 10 h in the absence of CO2. Scale-up experiments with the complete medium yielded 5 to 10 g, wet weight, of cells per liter. The complete medium was stable upon storage at 5 degrees C and after lyophilization.
Elder mistreatment in underserved populations: Opportunities and challenges to developing a contemporary program of research

ABSTRACT This article provides an overview of the status of research on elder mistreatment among underserved populations in the United States, including gaps in our current knowledge base and scientific and structural barriers to growing research on the exploitation, neglect, and abuse of older people from diverse and disadvantaged ethnic/racial, geographic, sexual identity, and socioeconomic groups. High-priority areas in need of new elder mistreatment research with underserved populations are identified, and suggestions are given for how this research can be facilitated by researchers, university institutional review boards, and funding agencies.
FMA: A Dataset for Music Analysis

We introduce the Free Music Archive (FMA), an open and easily accessible dataset suitable for evaluating several tasks in MIR, a field concerned with browsing, searching, and organizing large music collections. The community's growing interest in feature and end-to-end learning is however restrained by the limited availability of large audio datasets. The FMA aims to overcome this hurdle by providing 917 GiB and 343 days of Creative Commons-licensed audio from 106,574 tracks from 16,341 artists and 14,854 albums, arranged in a hierarchical taxonomy of 161 genres. It provides full-length and high-quality audio, pre-computed features, together with track- and user-level metadata, tags, and free-form text such as biographies. We here describe the dataset and how it was created, propose a train/validation/test split and three subsets, discuss some suitable MIR tasks, and evaluate some baselines for genre recognition. Code, data, and usage examples are available at this https URL