Miracle-dz/UniFAR-FTUs huggingface dataset:
Doing a Doc! – The thoughts, experiences and relationships of students undertaking a Professional Doctorate in Counselling

Aim: To explore the experiences of students undertaking a Professional Doctorate in Counselling. Method: The participants, students from years 1–6 on a Professional Doctorate programme within a UK university, were interviewed and the transcripts analysed using a thematic analysis approach. Themes identified include Personal Development, Expectations, Passion and Voice. However there is an overarching theme for these students' experiences of a ‘therapeutic edge’, which appears specific to them. Discussion: It seems clear that students undertaking this course of study will be challenged in a number of ways, as is also evidenced in the literature available. Conclusion: Students embarking on a Professional Doctorate in Counselling course may benefit from an understanding of the potential challenges they could face apart from the academic ones they perhaps anticipate. Such awareness might encourage them to identify good support systems to access throughout their studies.
Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2

ABSTRACT Mitogen-activated protein kinase (MAPK) pathways coordinate critical cellular responses to mitogens, stresses, and developmental cues. The coupling of MAPK kinase kinase (MAP3K) → MAPK kinase (MEK) → MAPK core pathways to cell surface receptors remains poorly understood. Recombinant forms of MAP3K MEK kinase 1 (MEKK1) interact in vivo and in vitro with the STE20 protein homologue germinal center kinase (GCK), and both GCK and MEKK1 associate in vivo with the adapter protein tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2). These interactions may couple TNF receptors to the SAPK/JNK family of MAPKs; however, a molecular mechanism by which these proteins might collaborate to recruit the SAPKs/JNKs has remained elusive. Here we show that endogenous GCK and MEKK1 associate in vivo. In addition, we have developed an in vitro assay system with which we demonstrate that purified, active GCK and TRAF2 activate MEKK1. The RING domain of TRAF2 is necessary for optimal in vitro activation of MEKK1, but the kinase domain of GCK is not. Autophosphorylation within the MEKK1 kinase domain activation loop is required for activation. Forced oligomerization also activates MEKK1, and GCK elicits enhanced oligomerization of coexpressed MEKK1 in vivo. These results represent the first activation of MEKK1 in vitro using purified proteins and suggest a mechanism for MEKK1 activation involving induced oligomerization and consequent autophosphorylation mediated by upstream proteins.
Jointly optimization and distributed control for interconnected operation of autonomous microgrids

The number of autonomous microgrids (MGs) which are difficult to connect with the main gird is increasing, especially for those on islands or isolated areas. It is helpful to optimize the operation and utilization of resource in different space and time by interconnecting nearby MGs together. A method of jointly optimization and distributed control for interconnected operation of autonomous MGs is proposed in this paper. Firstly, taking the minimum generation cost as objective a jointly optimization model is proposed. And then a dynamic droop control strategy is designed for the real-time control of CDERs in each MG, so as to keep the power on tie-line to the optimizing result, guaranteeing the autonomy of MGs. Finally, an example demonstrates the effectiveness on optimizing resource and reducing the cost of operation. The simulation result confirms the validity of the proposed dynamic control strategy.
Does Cohabitation Matter? Differences in Initial Marital Adjustment among Women who Cohabited and those who Did Not

In the study, we examined differences in marital adjustment and in personal and spousal variables related to marital adjustment among women who cohabited with their spouses before marriage versus those who did not. The noncohabiting women reported better levels of adjustment of spousal cohesion and display of affection, and they used strategies of concession to resolve marital conflicts to a greater extent than did women who cohabited. Among both groups of women, conflict resolution strategies correlated positively with marital adjustment, whereas the strategy of dominance and the attachment style of anxiety correlated negatively. In light of the research findings, practical recommendations are provided for preventive interventions among couples who cohabited before marriage and those who did not.
132 Phenotypic and Genotypic Aminoglycoside Resistance in Blood Culture Isolates of Coagulase Negative Staphylococci from A Single Neonatal Intensive Care Unit, 1989–2000

Background/aims: Coagulase-negative staphylococci (CONS) are the most prevalent pathogen causing late onset sepsis in neonates. A combination therapy including aminoglycosides is often used for empiric treatment of this condition. The aims of the study were to determine the susceptibility of neonatal CONS blood culture isolates to different aminoglycosides and to correlate the presence of genes encoding aminoglycoside modifying enzymes (AME) to amino-glycoside susceptibility pattern and methicillin resistance.Methods: Over a 12 years period 180 CONS blood culture isolates from one single neonatal unit were collected. According to standard definitions 95 isolates were classified as contaminants and 85 as invasive isolates. Susceptibility testing with Etest or the paper disk diffusion method was done for gentamicin, amikacin, netilmicin, tobramycin, arbekacin and oxacillin. Three different genes encoding AME [aac(6′)-Ie- aph(2“)-Ia, ant(4′)-I and aph(3′)-IIIa] and the methicillin resistance gene, mecA, were detected with PCR.Results: For tobramycin, gentamicin, netilmicin and amikacin 57 (32 %), 61 (34 %), 85 (47 %) and 110 (61 %) of all isolates, respectively, remained susceptible. No increase in aminoglycoside resistance rate was detected during the study period. The susceptibility rates were significant lower among invasive isolates versus contaminants. aac(6′)-Ieaph(2“)-Ia was encountered in 125 isolates (69 %), and 22 isolates (12 %) carried this gene in combination with the ant(4′)-Ia gene. Only 10 of 125 aac(6′)-Ieaph(2”)-Ia positive strains had gentamicin MIC≤2 mg/L, but 124 strains remained susceptible to arbekacin. However, 57 isolates highly resistant to gentamicin (MIC ≥128 mg/L) showed smaller arbekacin zone diameter (p < 0,001) than other isolates. Only 9 % of methicillin resistant strains were susceptible to gentamicin compared to 79 % of methicillin susceptible strains. Methicillin resistant strains remained susceptible to netilmicin (28 %), amikacin (48 %) and arbekacin (99 %). Conclusion: A high prevalence of aminoglycoside resistance was detected. Among the traditional aminoglycosides netilmicin or amikacin seems a better choice compared to gentamicin in the treatment of neonatal CONS infections. An optimal dosing regimen with high peak concentration will ensure best coverage for borderline resistant CONS strains. Arbekacin showed superior performance with antibacterial activity to 99.4 % of all isolates. We advocate including arbekacin in future clinical trials of empiric therapy of late onset neonatal sepsis.
Validation of microwave emission models by simulating AMSR-E brightness temperature data from ground-based observations

For several applications, spaceborne microwave measurements are used to get large scale information of snow- covered terrain. Emission models for soil, vegetation and snow are needed in extraction of snow parameters from satellite measurements. In this paper space-observed brightness temperature of snow-covered terrain is simulated from in situ measurements using HUT snow model, rough bare soil reflectivity model and boreal forest emission model. The results are compared with AMSR-E data. Correlations of time series between simulated and measured brightness temperatures were best on the highest frequencies being better than 0.7 on frequencies above 18 GHz.
ON THE DEVELOPMENT OF ADAPTIVE WEB-BASED LEARNING COMMUNITIES

Online learning communities may greatly benefit from incorporating adaptive features which take advantage of the knowledge and experiences of community members and use it to better serve each individual depending on personal preferences, goals and needs, as well as the history of activity in the community. This paper investigates the incorporation of adaptive features in online learning communities and focuses on deploying web mining techniques for this purpose. It presents a pilot system that experiments with the application of a number of adaptation forms and concludes with identifying some open issues and concerns in the domain of applying adaptiveness to web environments that host learning communities.
The Fab Fragment of a Human Anti-Siglec-9 Monoclonal Antibody Suppresses LPS-Induced Inflammatory Responses in Human Macrophages

Sepsis is a major cause of death for hospitalized patients and is characterized by massive overreaction of immune responses to invading pathogens which is mediated by cytokines. For decades, there has been no effective treatment for sepsis. Sialic acid-binding, Ig-like lectin-9 (Siglec-9), is an immunomodulatory receptor expressed primarily on hematopoietic cells which is involved in various aspects of inflammatory responses and is a potential target for treatment of sepsis. The aim of the present study was to develop a human anti-Siglec-9 Fab fragment, which was named hS9-Fab03 and investigate its immune activity in human macrophages. We began by constructing the hS9-Fab03 prokaryotic expression vector from human antibody library and phage display. Then, we utilized a multitude of assays, including SDS-PAGE, Western blotting, ELISA, affinity, and kinetics assay to evaluate the binding affinity and specificity of hS9-Fab03. Results demonstrated that hS9-Fab03 specifically bind to Siglec-9 antigen with high affinity, and pretreatment with hS9-Fab03 could attenuate lipopolysaccharide (LPS)-induced TNF-α, IL-6, IL-1β, IL-8, and IFN-β production in human PBMC-derived macrophages, but slightly increased IL-10 production in an early time point. We also observed similar results in human THP-1-differentiated macrophages. Collectively, we prepared the hS9-Fab03 with efficient activity for blocking LPS-induced pro-inflammatory cytokines production in human macrophages. These results indicated that ligation of Siglec-9 with hS9-Fab03 might be a novel anti-inflammatory therapeutic strategy for sepsis.
Image Projection over the Edge

Image projection is usually associated with image enlargement projected on screen or large display devices. The objective of this paper is to achieve sharper image projection and thinner transition over the edge. Tchebichef moment has been chosen here since it performs better than the popular Discrete Cosine Transform. This transform integrates a simplified mathematical framework technique using matrices, as well as a block-wise reconstruction technique. The result shows Tchebichef moment gives better image projection over the edge on graphical and real images.
The selected representation of contested prison history: memorial exhibitions and tourist experiences

The Jing-Mei Detention Centre, Taipei, is one of the primary sites associated with the ‘White Terror’, which took place during the imposition of Martial Law in Taiwan (1949–1987), by the authoritarian post-war regime of Chiang Kai-shek. Taiwan’s intelligence agencies violated civil rights and liberties. Suspects suffered arrest, interrogation, torture, trial, and imprisonment. The former detention centre has become Jing-Mei Human Rights Memorial and Cultural Park, which is one of two penal facilities dealing with the processing of political prisoners and for the suppression of activists who struggled for human rights. This study focuses on the interpretation by visitors of exhibitions at the site and the process of historical representation at the memorial park. The roles of the relevant parties were identified through interviews with former prisoners. The selection criteria, and the approaches to interpretation employed by the exhibition planners to represent a contested history, were examined. An analysis of visitor experiences and interaction with historical interpretation and layout in the exhibition demonstrated the visitors’ disoriented, yet unified, perceptions. A model of prison history has been developed that selects the memories and materials used to depict the past, unifying the multiple layers of histories during the ‘White Terror’.
Automated Spirometry Quality Assurance: Supervised Learning From Multiple Experts

Forced spirometry testing is gradually becoming available across different healthcare tiers including primary care. It has been demonstrated in earlier work that commercially available spirometers are not fully able to assure the quality of individual spirometry manoeuvres. Thus, a need to expand the availability of high-quality spirometry assessment beyond specialist pulmonary centres has arisen. In this paper, we propose a method to select and optimise a classifier using supervised learning techniques by learning from previously classified forced spirometry tests from a group of experts. Such a method is able to take into account the shape of the curve as an expert would during visual inspection. We evaluated the final classifier on a dataset put aside for evaluation yielding an area under the receiver operating characteristic curve of 0.88 and specificities of 0.91 and 0.86 for sensitivities of 0.60 and 0.82. Furthermore, other specificities and sensitivities along the receiver operating characteristic curve were close to the level of the experts when compared against each-other, and better than an earlier rules-based method assessed on the same dataset. We foresee key benefits in raising diagnostic quality, saving time, reducing cost, and also improving remote care and monitoring services for patients with chronic respiratory diseases in the future if a clinical decision support system with the encapsulated classifier is to be integrated into the work-flow of forced spirometry testing.
Predictive equations for central obesity via anthropometrics, stereovision imaging, and MRI in adults

Abdominal visceral adiposity is related to risks for insulin resistance and metabolic perturbations. Magnetic resonance imaging (MRI) and computed tomography are advanced instruments that quantify abdominal adiposity; yet field use is constrained by their bulkiness and costliness. The purpose of this study is to develop prediction equations for total abdominal, subcutaneous, and visceral adiposity via anthropometrics, stereovision body imaging (SBI), and MRI.
Increased Seroreactivity to Glioma-Expressed Antigen 2 in Brain Tumor Patients under Radiation

Background Surgery and radiation are the mainstays of therapy for human gliomas that are the most common primary brain tumors. Most recently, cell culture and animal studies provided the first convincing evidence that radiation not only eliminates tumor cells, but also modulates the immune response and likely improves anti-tumor immunotherapy. Methology/Pricipal Findings We present an in vivo study that analyzes the effects of radiation on the immune response in tumor patients. As readout system, we utilized the reactivity of glioma patients' sera against antigen GLEA2 as the most frequent antigen immunogenic in glioblastoma patients. We established an ELISA assay to analyze reactivity of 24 glioblastoma patients over a period of several months. As control we used 30 sera from healthy donors as well as 30 sera from lung cancer patients. We compared the course of GLEA2 seroreactivity at different times prior, during and after radiation. The GLEA2 seroreactivity was increased by the time of surgery, decreased after surgery, increased again under radiation, and slightly decreased after radiation. Conclusions/Significance Our results provide in vivo evidence for an increased antibody response against tumor antigens under radiation. Antigens that become immunogenic with an increased antibody response as result of radiation can serve as ideal targets for immunotherapy of human tumors.
Children as ‘differently equal’ responsible beings: Norwegian children’s views of responsibility

This article explores children’s views of responsibility and their position as responsible beings, drawing on an international research project with a focus on data from 109 children in Norway. Responsibility is explored as a practice that children experience as both a privilege and a burden in childhood. It is argued that there is an interwoven relation between participation rights and responsibilities for children, where ideas of the child as ‘being’ and ‘becoming’, ‘equal’ to and ‘different’ from adults are embedded. A difference-centred perspective is suggested as a way to accommodate children as ‘differently equal’ responsible beings.
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection

Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism and regulating host immune responses. Mice deficient in the RIG-I-MAVS pathway show defects in migratory dendritic cell (DC) activation, viral antigen presentation, and priming of CD8+ and CD4+ T cell responses during IAV infection. These defects result in decreased frequency of polyfunctional effector T cells and lowered protection against heterologous IAV challenge. In addition, our data show that RIG-I activation is essential for protecting epithelial cells and hematopoietic cells from IAV infection. These diverse effects of RIG-I signaling are likely imparted by the actions of type I interferon (IFN), as addition of exogenous type I IFN is sufficient to overcome the defects in antigen presentation by RIG-I deficient BMDC. Moreover, the in vivo T cell defects in RIG-I deficient mice can be overcome by the activation of MDA5 –MAVS via poly I:C treatment. Taken together, these findings demonstrate that RIG-I signaling through MAVS is critical for determining the quality of polyfunctional T cell responses against IAV and for providing protection against subsequent infection from heterologous or novel pandemic IAV strains.
The Projected Power Method: An Efficient Algorithm for Joint Alignment from Pairwise Differences

Various applications involve assigning discrete label values to a collection of objects based on some pairwise noisy data. Due to the discrete—and hence nonconvex—structure of the problem, computing the optimal assignment (e.g., maximum‐likelihood assignment) becomes intractable at first sight. This paper makes progress towards efficient computation by focusing on a concrete joint alignment problem; that is, the problem of recovering n discrete variables xi ∊ {1, …, m}, 1 ≤ i ≤ n, given noisy observations of their modulo differences {xi — xj mod m}. We propose a low‐complexity and model‐free nonconvex procedure, which operates in a lifted space by representing distinct label values in orthogonal directions and attempts to optimize quadratic functions over hypercubes. Starting with a first guess computed via a spectral method, the algorithm successively refines the iterates via projected power iterations. We prove that for a broad class of statistical models, the proposed projected power method makes no error—and hence converges to the maximum‐likelihood estimate—in a suitable regime. Numerical experiments have been carried out on both synthetic and real data to demonstrate the practicality of our algorithm. We expect this algorithmic framework to be effective for a broad range of discrete assignment problems. © 2018 Wiley Periodicals, Inc.
Incremental construction of Delaunay overlaid network for virtual collaborative space

This paper proposes an incremental algorithm for constructing the Delaunay overlaid network for virtual collaborative space. In our algorithm, every node uses Delaunay triangulation, by using its knowledge of other nodes and cooperatively exchanging information among nodes, which generates and refines overlaid networks. On the resultant Delaunay network, nodes communicate with each other over virtual collaborative space, and employ multihopping communication among distant nodes. This algorithm structure has the following advantages: (1) utilization of only the localized nodes, omitting the use of unnecessary distant nodes for communication, (2) scalability through surveillance of nodes by refining and updating the network continuously, (3) two dimensional space organization which allows construction of super nodes that govern regional areas to process geographical range query, and (4) directional communication through a small routing table. The authors believe that this approach is applicable to large-scale virtual collaborative space and location aware system.
The Inner Self Desires a Friendly Chat: Chat Metaphors in Turkish and English

This study presents a cross-cultural contrastive analysis of chat and its dictionary translation sohbet in Turkish. It aims to find out the source domains in the metaphorical expressions of chat in Turkish and English and what these source domains reflect regarding the two cultures because it is believed that metaphor is not just “in the heads” as a figure of speech but is embodied in cultural situations, and thus, is inseparable from the cultural context with which it interacts. In doing this, the method of conceptual metaphor theory is used and the data are collected from various corpora. The study has shown that although some conceptual metaphors are shared by both sohbet and chat expressions, some of these are more dominating in sohbet than in chat or vice versa. There are also conceptual metaphors unique to sohbet. The data analysis illustrates that sohbet is more structured and conventional, requiring certain conditions, whereas chat seems to be similar to everyday conversation. Motivation for the findings is discussed with reference to cultural background and Hofstede's and Varis's culture studies.
Numerical Study of Damage Evolution and Failure in an Electromagnetic Corner Fill Operation

A numerical study of an electromagnetic corner fill operation using AA5754 aluminum alloy sheet was performed. Conical parts with side angles of 40 and 45° (included angles of 100 and 90°) were modeled. The numerical calculations were performed with an explicit dynamic finite element structural code, using an analytical electromagnetic pressure distribution. Damage evolution was predicted using a damage subroutine based on the Gurson‐Tvergaard‐Needleman constitutive model. Experiments were performed to validate the numerical results. Damage measurements were made using optical microscopy to determine the actual damage produced by the forming operations. Predicted final shape, failure and damage levels are presented and compared with experimental results. The numerical models were able to accurately predict damage trends. Failure was predicted in general agreement with the experiments.