Miracle-dz/UniFAR-FTUs huggingface dataset:
Oncolytic Activity of Vesicular Stomatitis Virus Is Effective against Tumors Exhibiting Aberrant p53, Ras, or Myc Function and Involves the Induction of Apoptosis

ABSTRACT We have recently shown that vesicular stomatitis virus (VSV) exhibits potent oncolytic activity both in vitro and in vivo (S. Balachandran and G. N. Barber, IUBMB Life 50:135–138, 2000). In this study, we further demonstrated, in vivo, the efficacy of VSV antitumor action by showing that tumors that are defective in p53 function or transformed with myc or activatedras are also susceptible to viral cytolysis. The mechanism of viral oncolytic activity involved the induction of multiple caspase-dependent apoptotic pathways was effective in the absence of any significant cytotoxic T-lymphocyte response, and occurred despite normal PKR activity and eIF2α phosphorylation. In addition, VSV caused significant inhibition of tumor growth when administered intravenously in immunocompetent hosts. Our data indicate that VSV shows significant promise as an effective oncolytic agent against a wide variety of malignant diseases that harbor a diversity of genetic defects.
Local Partnerships and Social Exclusion in the European Union: New Forms of Local Social Governance? Edited by Mike Geddes and John Benington. London: Routledge, 2001. 254p. $90.00

This book, the product of collaboration by an international team of European social scientists, focuses on the emergence and operation of local partnerships to combat social exclusion in European Union nations. This timely study is built on case analysis of samples of local partnerships in 10 EU nations; seven are given chapter-length treatment in the book. The central goals of the authors are to explain the cross-national diversity in frequency and form of local partnerships and their successes and failures in addressing poverty and social exclusion.
Análise cinética dos distúrbios de marcha nos pacientes com esclerose múltipla: proposta de categorização e suas possíveis repercussões no desempenho

A Esclerose Multipla (EM) provoca disturbios de marcha que interferem na independencia e no desempenho nas atividades de vida diaria. Por isso, para compreender as suas causas biomecânicas este estudo focou na analise Cinetica da marcha, especificamente na analise do componente vertical da forca de reacao ao solo (CVFRS). Pois, este permite estimar os prejuizos na capacidade de impulsionar o centro de massa para cima, o que repercute na capacidade de propulsao e estabilizacao do membro, e consequentemente no desempenho da marcha como um todo. Componente que pode ser avaliado de forma mais objetiva com o uso da classificacao de Ben Lomonding, que a categoriza em niveis de alteracoes. Porem, esta classificacao foi testada apenas em criancas com Paralisa Cerebral. Objetivos: Analisar a cinetica dos disturbios de marcha na EM e suas repercussoes sobre o desempenho nos parâmetros temporais e espaciais da marcha, em pacientes com diferentes niveis de comprometimento. Metodos: Estudo transversal caso controle que avaliou a marcha em velocidade autoselecionada de 50 adultos saudaveis (25 homens e 25 mulheres) e 49 pacientes adultos (42 mulheres e 7 homens) com EM cuja nota na Expanded Disability Status Scale (EDSS) variou entre 1.5 e 6.0. Recrutados no Centro de Referencia e Investigacao em Esclerose Multipla do servico de neurologia do Hospital das Clinicas da Universidade Federal de Goias e avaliados no Laboratorio de Analise do Movimento do Centro de Reabilitacao Dr.o Henrique Santillo. A analise instrumentada da marcha foi realizada pelo sistema VICON® e 4 plataformas de forca da marca AMTI®. A analise da “speed fast” realizada por meio do teste Timed 25-foot Walk (T25FW). As avaliacoes ocorreram no periodo matutino e foram executadas por apenas um avaliador durante todo o estudo. A categorizacao do CVFRS adotou a Classificacao de Ben Lomonding. Resultados: Foi possivel categorizar o CVFRS de todos os pacientes com EM de acordo com a classificacao de Ben Lomonding, pois as alteracoes encontradas estavam de acordo com os tipos 0 a 3, e A. Observou-se que pacientes com maior gravidade da doenca apresentaram maior reducao do segundo pico do CVFRS (FZ2). Pacientes com maior reducao de FZ2 apresentaram pior desempenho no teste T25FW, na cadencia, velocidade, comprimento de passo e passada, tempo de suporte duplo e tempo total de apoio. Tambem, tiveram maior comprometimento cerebelar. Conclusoes: A classificacao de Ben Lomonding pode ser aplicada em adultos com EM e por meio dela foi possivel verificar que quanto pior o nivel de incapacidade da EM pior a reducao de FZ2. Na analise dos sistemas funcionais, quanto maior o comprometimento cerebelar pior a reducao de FZ2. Por sua vez os pacientes deste estudo tiveram pior desempenho na marcha quando havia uma maior reducao de FZ2.
Genetic and environmental influences on the rate of progression to alcohol dependence in young women.

BACKGROUND The development of alcohol dependence (AD) involves transitions through multiple stages of drinking behaviors and is shaped by both heritable and environmental influences. We attempted to capture this dynamic process by characterizing genetic and environmental contributions to the rate at which women progressed through 3 significant transitions along the pathway to AD: nonuse to initiation, initiation to onset of first alcohol-related problem, and first problem to onset of AD. METHODS The sample consisted of 3,546 female twins from the Missouri Adolescent Female Twin Study. Participants ranged in age from 18 to 29 years. Retrospective reports of alcohol use histories were collected by telephone diagnostic interview and transition times between drinking milestones were coded ordinally. Standard genetic analyses were conducted in Mx to derive a trivariate model that provided estimates of genetic and environmental influences that were common as well as specific to the 3 transition times. RESULTS Heritable influences were found for rate of progression across all 3 transitions, accounting for 30 to 47% of the variance in transition times. Shared environmental contributions were evident only in rate of progression from nonuse to initiation (i.e., age at first drink). Heritable contributions to the rate of movement through successive drinking milestones were attributable to a common factor, whereas environmental influences were transition-specific. CONCLUSIONS The current study is unique in its use of a genetically informative design to document the rate of movement between drinking milestones in a female sample and to examine genetic contributions to multiple transition times over the course of AD development. Results indicate that an earlier report of heritability for males in rate of progression from regular drinking to AD generalizes to women and to other alcohol stage transitions. Findings also suggest the need to consider stage-specific environmental contributions to alcohol outcomes in developing interventions.
Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis.

PURPOSE To investigate pathogenesis underlying endogenous uveitis, macrophage migration inhibitory factor (MIF) was quantified in sera of patients. METHODS Sera were obtained from the 55 patients with uveitis (24 with Behçet's disease; 9 with Vogt-Koyanagi-Harada's [VKH] disease; 22 with sarcoidosis) and 58 healthy control subjects. MIF levels were determined by a human MIF enzyme-linked immunosorbent assay. RESULTS The mean MIF levels in the sera of the patients with Behçet's disease, VKH disease, and sarcoidosis and of healthy control subjects were 60.4+/-9.0 (mean+/-SE) ng/ml, 16.5+/-2.9 ng/ml, 27.1+/-5.6 ng/ml, and 5.4+/-0.04 ng/ml, respectively. The average levels of MIF in the sera of uveitis patients were significantly higher (P < 0.0001) than those of healthy control subjects. The high levels of MIF were especially noted in patients with Behçet's disease at the ocular exacerbation stage and patients with sarcoidosis at the severe uveitis stage. CONCLUSIONS Significant increase of MIF in sera was characteristic of uveitis, and MIF may be a usefull laboratory parameter to use to comprehend the clinical course of uveitis.
PLASMA AND CYTOPLASMIC MEMBRANE FRAGMENTS FROM EHRLICH ASCITES CARCINOMA.

were corrected to 4°. The coefficients of expansion of Ficoll solutions of density 1.04 and 1.10 were 2.6 and 1.7-10-4 gM.cm-3 per 0C, respectively. Because of poor drainage with viscous Ficoll solutions, multiple pipettes were necessary. (9) Examination of density gradients: The linearity of uncentrifuged gradients was demonstrated in a number of experiments. However, since Ficoll sediments during prolonged centrifugation, it was necessary to measure the density gradient in each tube after centrifugation.
Simulation on Boron Concentration Profile in Silicon Introduced by Plasma Doping

Plasma doping (PD) is a potential shallow junction technology for advanced integrated circuits manufacturing. Accurate simulation on PD is thus needed. The simulation on PD induced B concentration profile in Si is presented in this paper. A computational efficiency Molecular Dynamics (MD) method is applied. The plasma potential, the deviation of ion energy, and the injection angle are considered. The effect of physical models, including different ion species, threshold energy of displacement, energy variation model, electronic stopping model, is investigated. It is demonstrated that the proper agreement between simulation results and experimental data can be achieved for PD.
A tool for simplifying automatic categorization of scientific paper using Watson API

More than a decade many scientific papers have been dealing with automatic categorization of documents. Until recently there were no wide spread tools or libraries that could be integrated in a custom application. Recent cloud solutions for cognitive computing eased such integration, but integration still requires a lot of work. An idea of extendible library for simplifying document parsing and categorization using IBM Watson API is developed and presented in this paper. As a proof of concept nearly one hundred of scientific papers in a scientific journal were parsed and analysed using Watson API to detect key topics and concepts of each paper which were then compared with keywords provided by the author.
Target-Motion-Induced Radar Imaging

Imaging from ground-based (stationary) radars of moving targets is often possible by utilizing a "synthetic aperture" developed from the target motion itself. The theory and experimental results associated with such processing are addressed. An aircraft is imaged from both a straight flight and a turn with recognizable results. Analysis shows that two-phase components exist in the radar return, one being gross velocity induced, the other being interscatterer interference within the target itself. The former phase must be removed prior to imaging and techniques are developed for this task. Preprocessing, range curvature, range alignment, motion compensation, and presumming are all addressed prior to presenting the experimental results. Coherence processing intervals, range collapsing, and range realignment are all examined during the processing aspects of the paper.
Serotonin‐Mediated Increases in the Extracellular Levels of β‐Endorphin in the Arcuate Nucleus and Nucleus Accumbens : A Microdialysis Study

Abstract : Although the involvement of both endogenous opioid and serotonergic systems in modulation of pain and emotion was suggested, the neurochemical interaction between these systems in the brain has not previously been studied directly. Herein, the effects of the local application of serotonin (5‐HT) and fluoxetine (a 5‐HT reuptake inhibitor) on extracellular levels of β‐endorphin in the arcuate nucleus and nucleus accumbens were assessed in freely moving rats using in vivo microdialysis. The mean basal concentrations of β‐endorphin in dialysates obtained from the arcuate nucleus and nucleus accumbens were 259.9 and 143.3 pM, respectively. Specific lesion of the serotonergic system by 5,7‐dihydroxytryptamine (5,7‐DHT) caused a significant decrease in these dialysate β‐endorphin levels. When 5‐HT (0.25‐5 μM) was added to the perfusion solution, the levels of β‐endorphin in the dialysate from the arcuate nucleus increased (186‐296% of baseline), in a concentration‐dependent manner. In the nucleus accumbens, 0.5 and 2 μM 5‐HT in the perfusion fluid did not affect the levels of β‐endorphin in the dialysate, whereas 5 and 10 μM 5‐HT caused an increase of ~190% of baseline. When fluoxetine (250 μM) was present in the perfusing solution, the levels of β‐endorphin in the dialysates from the arcuate nucleus and nucleus accumbens increased two‐ to three‐fold. This effect was not obtained in the 5,7‐DHT‐lesioned rats. Thus, 5‐HT, either endogenously or exogenously delivered, appears to facilitate the release of β‐endorphin in the arcuate nucleus and nucleus accumbens. This indication of an interaction between serotonergic and endorphinic systems may be relevant for assessing pain and mood disorder circuits and the mode of action of antidepressant drugs.
Verification of parametric system designs

System designs are often modeled as sets of threads whose activations are controlled by a domain-specific scheduler. Especially in the early design phases, the interactions between the threads and the scheduler often depend on parameters (such as the duration of thread suspensions) for which a value is not available. In this paper, we tackle the verification of designs with parametric scheduler-thread interaction. We propose a new method, called Semi-Symbolic Scheduler/Symbolic Threads (S3ST), to prove that a design satisfies the specified assertions for all possible values of the interaction parameters. We build on Explicit-Scheduler/Symbolic-Threads (ESST), an effective technique for verifying designs with cooperative scheduling, that is however limited to the case of non-parametric interactions. As in ESST, S3ST analyzes each thread symbolically using lazy predicate abstraction. The key difference is in the way the scheduler is dealt with. In ESST, the scheduler is directly executed, using techniques similar to explicit-state model checking. In S3ST, the scheduler is analyzed by combining concrete execution of parts of its state, with the evolution of a symbolically represented set of configurations of interaction parameters. We have implemented S3ST in the Kratos software model checker, and have performed an experimental evaluation on a significant set of benchmarks with parametric scheduler-thread interaction. The results clearly demonstrate the effectiveness of the new approach.
Enantioselectivity of some 1‐(benzofuran‐2‐yl)‐1‐(1‐H‐imidaz‐1‐yl) alkanes as inhibitors of P450 AROM

The low stereospecificity of the enantiomers of 1-[(benzofuran-2-yl)-4-chlorophenylmethyl]imidazole (6, R=H, R'=4'-Cl) and the corresponding 4-fluoro compound as inhibitors of aromatase (P450Arom) has been explored using 1-(5,7-dichlorobenzofuran-2-yl)-1-(1H-imidaz-1-yl)ethane (7, R1=R2=Cl, R=CH3), -propane (7, R1=R2=Cl, R=C2H5), and the corresponding 5,7-dibromo compounds resolved as their dibenzoyl-D (or -L) tartrates. Low enantioselectivity ratios of 4.8 (5,7-diCl) and 12.6 (5,7-diBr) were shown for the ethanes. The values for the corresponding propanes were 8.3 and 5.2, respectively, and for these compounds the stereoselectivity was reversed.
ENERGY AND SLA EFFICIENT VIRTUAL MACHINE CONSOLIDATION IN CLOUD DATA CENTERS Preethi

77 Abstract— In cloud computing, the modern cloud data centers are hosting a variety of advanced applications and the IT infrastructure over the recent years because of the demand for computational power infrastructure which are widely used by some of the applications increasing rapidly. Due to the enormous amount of electrical energy consumed by the huge cl oud data centers, the operating cost and the emission of car bon dioxide (Co2) produces the high value as a result. In order to reduce the energy consumption and to increase the physical res ource utilization in data centers, the most effective way used is a dynamic consolidation of virtual machines (VMs). The main purpose of this paper is to provide a novel method which is used in dynamic virtual machine consolidation. This proposed novel method has outperformed the existing policies in te rms of energy consumption, SLA violation and VM migration time by surveying the determination of underloaded hosts, determination of overloaded hosts, selection of VM and placement of the migrating VMs.
Intrapulmonary Solitary Fibrous Tumors: Clinicopathologic and Immunohistochemical Study of 24 Cases

Solitary fibrous tumor (SFT) is a ubiquitous neoplasm that arises most commonly from the pleura. SFT arising within lung parenchyma (intrapulmonary SFT) has been rarely reported and is therefore not well recognized. We present a clinicopathologic and immunohistochemical study of 24 cases of primary intrapulmonary SFT. Patients’ ages ranged from 44 to 83 years (mean, 58 y). None of the patients had evidence or history of a similar tumor elsewhere. Tumor size ranged from 2.3 to 22 cm (mean, 8.5 cm). On the basis of the degree of cytologic atypia, cellularity, mitotic activity, and areas of necrosis, the lesions were divided into low-grade, intermediate-grade, and high-grade histology. Twenty-one tumors showed the conventional features of SFT of low-grade histology (<5 mitoses per 10 high-power fields), with alternating bands of rope-like collagen flanked by a bland-appearing spindle cell proliferation. Hemangiopericytic, angiofibromatous, and a neural-like plexiform growth pattern were also observed. Five of 21 cases showed an “adenofibromatous” appearance imparted by entrapped normal airspaces at the advancing edges of the lesion. One intermediate-grade tumor showed overall increased cellularity with plump, pleomorphic nuclei, 5 to 10 mitoses per 10 high-power fields, and focal areas of classic SFT. Two cases showed high-grade features at initial presentation, with areas resembling a pleomorphic high-grade sarcoma admixed with foci of conventional, low-grade SFT. Immunohistochemical staining analyses performed in 13 cases showed positivity of the tumor cells for CD34, bcl-2, and CD99 in the majority of cases tested. Clinical follow-up was available in 18 patients, with long-term follow-up (>5 y) in 6. Fourteen (14/18) patients were alive and well without evidence of disease 1 month to 14 years after initial diagnosis. Three patients died of their tumors after 4, 5, and 7 years; in 2 of them the initial tumor was of low-grade histology, but the recurrence/metastases showed a high-grade histology; the third fatal case showed a tumor with high-grade histology at initial diagnosis. One patient with intermediate-grade histology also had chest wall metastases at 5 years but was subsequently lost to follow-up. The results of our study indicate that although tumors with overtly malignant histologic features can be expected to behave as high-grade sarcomas, tumors with bland-appearing morphologic features at presentation may also follow an aggressive behavior. Adequate excision with close clinical follow-up, thus, appears to be the most prudent course of action for the management of primary intrapulmonary fibrous tumors.
Statistical Timing Modeling Based on a Lognormal Distribution Model for Near-Threshold Circuit Optimization

Near-threshold computing has emerged as one of the most promising solutions for enabling highly energy efficient and high performance computation of microprocessors. This paper proposes architecturelevel statistical static timing analysis (SSTA) models for the near-threshold voltage computing where the path delay distribution is approximated as a lognormal distribution. First, we prove several important theorems that help consider architectural design strategies for high performance and energy efficient near-threshold computing. After that, we show the numerical experiments with Monte Carlo simulations using a commercial 28 nm process technology model and demonstrate that the properties presented in the theorems hold for the practical near-threshold logic circuits. key words: near-threshold computing, statistical static timing analysis (SSTA)
Effectiveness of rapid response teams on rates of in-hospital cardiopulmonary arrest and mortality: A systematic review and meta-analysis.

BACKGROUND In 2004, the Institute for Healthcare Improvement's 100,000 Lives Campaign recommended that hospitals implement rapid response teams (RRTs) charged with identifying non-intensive care unit (ICU) patients at risk for rapid deterioration. Although RRTs are now in widespread use, there have been conflicting results regarding the impact of RRTs on hospital mortality and cardiopulmonary arrest. PURPOSE To assess the effectiveness of RRTs on reducing hospital mortality and non-ICU cardiopulmonary arrest rates. DATA SOURCES We conducted a systematic review using MEDLINE (1966-2014), Cochrane Central Register of Controlled Trials (1898-2014), Cumulative Index to Nursing and Allied Health Literature (1994-2014), and ClinicalTrials.gov (1997-2014) during October 2014. There were no constraints on language or publication status. DATA EXTRACTION We included before-after studies, cohort studies, and cluster randomized trials that reported hospital mortality and/or non-ICU cardiopulmonary arrest for adults hospitalized in a non-ICU setting after the implementation of RRTs and/or medical emergency teams (METs). Data were extracted by 2 sets of 2 independent reviewers using a standardized data-collection form. Disagreements were resolved by a third reviewer. Authors were contacted to obtain any missing data. DATA SYNTHESIS Our search identified 691 studies, of which 30 met criteria for inclusion in the analysis. Implementation of an RRT/MET was associated with a significant decrease in hospital mortality (relative risk [RR] = 0.88, 95% confidence interval [CI]: 0.83-0.93, I(2) = 86%, 3,478,952 admissions) and a significant decrease in the number of non-ICU cardiac arrests (RR = 0.62, 95% CI: 0.55-0.69, I(2) = 71%, 3,045,273 admissions). CONCLUSIONS Implementation of an RRT/MET is associated with a reduction in both hospital mortality and non-ICU cardiopulmonary arrests. Journal of Hospital Medicine 2016;11:438-445. © 2016 Society of Hospital Medicine.
Phoneme segmentation of speech signal

This paper proposes a phoneme segmentation method based on pattern similarity measurement between two consecutive time-series voiced speech signal. System first performs pitch detection by using dyadic wavelet transform. Then, Pattern similarity measurement has been carried out to act as phoneme boundaries detector. Output result has been compare to manual phonemic segmentation. Proposed method proves effective in finding phoneme boundaries.