Miracle-dz/UniFAR-FTUs huggingface dataset:
The pcnB gene of Escherichia coli, which is required for ColE1 copy number maintenance, is dispensable

The pcnB gene product of Escherchia coli is required for copy number maintenance of plasmids related to ColE1 and also for that of the IncFII plasmid R1. Because PcnB is similar to the tRNA-binding protein tRNA nucleotidyltransferase, we have suggested that the protein would be required only for processes in which an RNA is a prominent regulatory component. This appears to be so; strains deleted for pcnB, although defective in ColE1 and R1 plasmid maintenance, maintain the iteron-regulated plasmids F and P1 normally. We also find that strains deleted for pcnB grow normally, demonstrating that PcnB has no essential cellular role under the conditions tested and suggesting that regulation by antisense RNAs similar to RNAI has no critical role in any essential host process. We confirm by immunological tests that PcnB is likely to be the commercially available enzyme poly(A) polymerase.
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.

OBJECTIVES There is good evidence that opioids can potentiate analgesic activity of some older non-opioid analgesics (such as paracetamol or ibuprofen) but it is not known whether this also holds true for newer non-opioid analgesics that selectively inhibit cyclooxygenase 2 (coxibs). This study was undertaken to determine the nature of the interaction between codeine and celecoxib or etoricoxib in peritoneal irritation-induced visceral pain in mice. For comparison, interactions of codeine with paracetamol and ibuprofen were also tested using the same method. MATERIAL AND METHODS A small volume of a weak acetic acid (0.6%) was injected into the peritoneal cavity and the number of writhes (contractions of abdominal muscles) was counted. All drugs were given orally. Their interaction was characterized using isobolographic analysis. RESULTS Codeine, etoricoxib, celecoxib, ibuprofen and paracetamol all independently produced dose-dependent suppression of writhing. The isobolographic analysis carried out using equipotent dose ratios showed that the interactions between codeine and etoricoxib or celecoxib were sub-additive or additive, respectively. This was in contrast to combinations of codeine with ibuprofen or paracetamol, which were supra-additive. Interaction indexes γ, determined as a ratio between experimental and theoretical ED50 values of the mixture, were as follows: 2.7 for codeine + etoricoxib, 0.62 for codeine + celecoxib, 0.43 for codeine + ibuprofen and 0.33 for codeine + paracetamol. CONCLUSIONS These and other results suggest that opioids do not seem to potentiate analgesic effects of selective COX-2 inhibitors, in contrast to nonselective COX inhibitors or paracetamol.
A Cost-Benefit Analysis of Federal Job Training Investments in Community Colleges.

of Dissertation . v List of Figures . viii List of Tables . ix Chapter 1: Introduction . 1 The Importance of Postsecondary Education and Training in the United States . 3 Job Training in the United States . 6 Community Colleges and Their Role in Providing Job Training . 16 Innovations in Job Training at Community Colleges – The Career Pathways Model . 27 Federal Grant Programs for Job Training in Community Colleges . 31 Research Summary . 43 Organization of the Remainder of the Dissertation . 47 Chapter 2: Review of the Relevant Literature . 48 Theoretical Grounding for the Mission of Community Colleges to Provide Job Training . 48 Labor Market Returns to Job Training . 52 A Cost-Benefit Framework for Understanding Federal Investments in Job Training at Community Colleges . 64 Summary of the Chapter . 75 Chapter 3: Research Methods . 76
Oil prices and sovereign credit risk of oil producing countries: an empirical investigation

The low oil price recently has caused fears about the sustainability of public finances in some oil producing countries. We examine the relationship between oil prices and sovereign credit risk examining the CDS market. Analysing data from nine countries (Brazil, Malaysia, Norway, Qatar, Russia, Saudi Arabia, the United Kingdom, the United States of America and Venezuela) we have estimated bivariate VAR-GARCH-in-mean models. The results of our empirical investigations generally speaking do suggest that positive oil price shocks lead to lower sovereign CDS spreads. Thus, our findings support the hypothesis that higher oil prices improve the fiscal stability of oil producing countries.
The complete structure of the cucumber (Cucumis sativus L.) chloroplast genome: Its composition and comparative analysis

The complete nucleotide sequence of the cucumber (C. sativus L. var. Borszczagowski) chloroplast genome has been determined. The genome is composed of 155,293 bp containing a pair of inverted repeats of 25,191 bp, which are separated by two single-copy regions, a small 18,222-bp one and a large 86,688-bp one. The chloroplast genome of cucumber contains 130 known genes, including 89 protein-coding genes, 8 ribosomal RNA genes (4 rRNA species), and 37 tRNA genes (30 tRNA species), with 18 of them located in the inverted repeat region. Of these genes, 16 contain one intron, and two genes and one ycf contain 2 introns. Twenty-one small inversions that form stem-loop structures, ranging from 18 to 49 bp, have been identified. Eight of them show similarity to those of other species, while eight seem to be cucumber specific. Detailed comparisons of ycf2 and ycf15, and the overall structure to other chloroplast genomes were performed.
An examination of the relationship between employee resourcing and professionalism: a case study of Nigerian public service

The study examined the concept of professionalism and its relationship to employee resourcing with special emphasis on the effect of application of knowledge, skills and attitudes to staffing within the organization. The population consisted of Nigeria public servants. Both quantitative and qualitative methods of data collection were adopted; four hundred and seventy six (476) useable questionnaires were retrieved from respondents and used in the quantitative analysis, while three different groups consisting of between eight to twelve people were involved in focus group discussions. The authors found among others that the Nigerian public service is made up of an aged workforce. Following this, it is recommended that the public service should present better employment incentives to attract young and talented workforce. It is also suggested that the corporate autonomy of HR departments must be respected; employee resourcing should be handled without interference. While a lack of professionalism within the Nigerian public service is noted in this study, the authors hasten to assert that this is partly as a result of the learning environment in Nigeria which is considered unsuitable and ill-equipped for quality learning.
A trajectory tracking control strategy based on finite element method for planar three-link underactuated manipulator

This paper presents a trajectory tracking control strategy based on the finite element method for a planar three-link underactuated manipulator with a passive third joint. From the mechanical structure, the manipulator can be thought of as composed of two parts. The first part is the first link of the manipulator, which is a single link manipulator system. The second part consists of the remaining two links, which can be seen as a plananr Pendubot. First, a finite element model of the planar Pendubot is built by using COMSOL, and the coupling relationship between its active link and its passive link is analyzed. Then, two servo controllers (A and B) with the same structure are designed for two active links of the manipulator, respectively. The servo controller A is directly applied to control the angular velocity of the first link of the manipulator rotating with a constant speed, which makes the end-point of the manipulator move along the trajectory direction. Next, a fuzzy system is designed based on the coupling relationship of the planar Pendubot to calculate the target angular velocity of the second link of the manipulator according to the tracking error and its change rate. The servo controller B is applied to control the angular velocity of the second link of the manipulator, which makes the tracking error converge to zero. Finally, Simulation results demonstrate the effectiveness and the robustness of the proposed control strategy.
Culture and innovation in SMEs: the intellectual structure of research for further inquiry

ABSTRACT Regional and organizational cultures are commonly considered key enablers to innovation dynamics in organizations, in particular to small and medium enterprises (SMEs). Although this intersection is a crucial topic of research, studies addressing this issue remain limited in number and scope in the case of SMEs. In this article, a systematic literature review of that intersection is presented by gathering articles from ISI-WoS and Scopus databases. It combines a qualitative approach (content analysis) and a statistical procedure (HOMALS) to analyse the information from 1947 articles found. As a result, the contribution is twofold: a map of the intellectual structure of research and a codebook of descriptors. The study helps identify relevant gaps for future research, specifically the need for mixed approaches from a variety of social sciences with a particular focus on regional science. Future research should shift from a static to a dynamic perspective of culture in groups, organizations and territories. In the case of SMEs, this can be labelled as transformational culture: the study of how organizational and regional cultures may co-evolve along with the changes in the environment by seizing on the SMEs’ flexibility and flattened organizational structure.
Distributed antenna systems and linear relaying for gigabit MIMO wireless

Spatial multiplexing is mandatory to achieve the extreme bandwidth efficiency of future gigabit/sec WLAN. Both distributed antenna systems (DAS) at the access point and cooperative relaying (the infrastructureless counterpart) have been recognized as means to meet coverage/range requirements and to enable spatial multiplexing in a low scattering environment. In this paper we evaluate three candidate schemes under a two-hop (relay) traffic pattern: (i) DAS with decode and forward in the access point (DDAS), (ii) DAS with linear processing in the access point (LDAS) and (iii) linear relaying without any information exchange between the relay nodes. We give lower bounds on the capacity of LDAS and DDAS. A main contribution of this paper is a systematic derivation of local gain allocation strategies for linear relaying with multi-antenna source and destination nodes, which are based on large system analysis and do not require global channel knowledge at the relays. We derive approximate expression for the ergodic capacity. We show for a source and destination with M antennas, that asymptotically (large number of relays) linear relaying with MN support nodes performs similar to LDAS with M distributed antenna elements. Finally we propose a zero forcing gain allocation, which enables spatial multiplexing of multiple single antenna source/destination pairs based on a small number of autonomous relays. The theory is supported by comprehensive performance results.
A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus

Ticks are obligate blood‐feeding arachnids. During their long‐lasting blood meal, they have to counteract the protective barriers and defense mechanisms of their host. These include tissue integrity, pain, hemostasis, and the inflammatory and immune reactions. Here, we describe a multigene family coding for five putative salivary metalloproteases induced during the blood meal of Ixodes ricinus. The evolutionary divergence inside the family was driven by positive Darwinian selection. This came together with individual variation of expression, functional heterogeneity, and antigenic diversification. Inhibition of the expression of some of these genes by RNA interference prevented completion of the tick blood meal and affected the ability of the tick saliva to interfere with host fibrinolysis. This family of proteins could therefore participate in the inhibition of wound healing after the tick bite, thereby facilitating the completion of the blood meal.
Economic Development Matters: A Meta‐Regression Analysis on the Relation between Environmental Management and Financial Performance

Although the existing body of empirical literature on the relation between corporate environmental performance (CEP) and corporate financial performance (CFP) is continuously growing, results are still inconclusive about this fundamental question in industrial ecology. Comparisons are difficult because of various estimation methods as well as the overall heterogeneous and complex interaction between the two constructs, but especially because of country‐specific data sets. Consequently, we raise the question of whether regional differences are the driving force buried underneath the inconclusiveness. Therefore, the aim of this article is to explore this heterogeneity by aggregating 893 existing results from 142 empirical primary studies that are based on more than 750,000 firm‐year observations. Our findings suggest a convex impact of a country's economic development on the magnitude of the CEP‐CFP effect (i.e., the effect is positive in developing countries, disappears in emerging countries, and is again positive in highly developed countries). We also find that the overall positive relation strengthens for market‐based CFP measures and diminishes for countries with civil law systems, firms from the service sector, reactive environmental activities, and process‐based CEP measures. Further, several aspects of the examined data sample and the inclusion of relevant control variables explain heterogeneity in previous research results.
Cardiovascular risk in pediatric type 1 diabetes: sex‐specific intima‐media thickening verified by automatic contour identification and analyzing systems

Krebs A, Schmidt‐Trucksäss A, Doerfer J, Grulich‐Henn J, Holder M, Hecker W, Krebs K, Barth M, Schwab KO. Cardiovascular risk in pediatric type 1 diabetes: sex‐specific intima‐media thickening verified by automatic contour identification and analyzing systems.
Flexible runtime verification based on logical clock constraints

We present in this paper a method and tool for the verification of causal and temporal properties of embedded systems, by analyzing the trace streams resulting from virtual prototypes that combines simulated hardware and embedded software. The proposed method makes it possible to analyze different kinds of properties without rebuilding the simulation models. Logical clocks are used to identify relevant points to put observation probes and thus also reducing the trace streams size. We propose a property specification language, called PSML, and based on behavioral patterns that does not require knowledge of temporal logics. From a given PSML specification, simulation is instrumented to generate a trace and the code is dynamically loaded by the simulator. The resulting trace stream is analyzed by parallel automata generated from the specification. The experiments, developed over the SimSoC virtual prototyping framework, show flexibility, possibility of using multi-core platforms to parallelize simulation and verification, providing fast results.
Catecholamine‐containing neurons in the sheep brainstem and diencephalon: Immunohistochemical study with tyrosine hydroxylase (TH) and dopamine‐β‐hydroxylase (DBH) antibodies

The present study describes the distribution and morphological characteristics of neurons and nerve fibers containing the catecholamine‐synthesizing enzymes, tyrosine hydroxylase and dopamine‐β‐hydroxylase, in the sheep brainstem and diencephalon on the basis of immunohistochemical procedures. Neurons and fibers were considered to be dopaminergic if they showed antityrosine hydroxylase immunoreactivity, without corresponding anti‐dopamine‐β‐hydroxylase immunoreactivity. The structures labeled with both antisera were considered noradrenergic or adrenergic. The distribution of catecholaminergic neurons corresponds to that described by other authors with similar methods in the rat and in primates. The noradrenergic neurons belong to cell groups A1 to A7 and the dopaminergic neurons to cell groups A8 to A15. In almost all studied areas, the catecholaminergic innervation is similar to that observed in the other species. However, the central catecholaminergic systems of the sheep showed some specific characteristics: (1) groups A3 and A4, described in the rat, were not found, (2) group A14 contains fewer neurons than in the rat, (3) group A15 does not contain a dorsal but only a ventral portion, (4) there is a larger dispersion of neurons within each group, especially A6 and A7, than in rodents, and (5) there is a larger noradrenergic innervation of the catecholaminergic groups than in the other species.
A novel c.C2754?>?T transition in the androgen receptor gene introduces the premature termination codon Q798X and results in a truncated form of the receptor

A genetic analysis of a female with a 46,XY genotype and typical symptoms of the complete androgen insensitivity syndrome (CAIS) was conducted. The patient was diagnosed with an abdominal tumor due to the presence of a Sertoli cell adenoma in both gonads. Multiple temperature single-stranded conformational polymorphism (MSSCP) and sequence analyses of the androgen receptor gene revealed a c.C2754 > T mutation in exon 6. This mutation, which has not been previously reported, alters a Gln codon to a termination codon (Q798X). This results in the interruption of the amino acid sequence of the androgen receptor within the ligand-binding domain between helices VII and VIII. The truncated form of the receptor is devoid of 123 amino acids at the carboxyl end, a major part of the ligand-binding domain, and the AT2 sequence responsible for the activation of the transcription. It was concluded that the novel c.C2754 > T transition rendered the androgen receptor incapable of both ligand binding and activating the transcription, and was the cause of CAIS in the patient.
Endotoxic-lipopolysaccharide-specific binding proteins on lymphoid cells of various animal species: association with endotoxin susceptibility

Endotoxic lipopolysaccharide (LPS), a common structural component of all gram-negative bacteria, is well recognized for its capacity to interact with and perturb immunologically relevant cells. Using a radioiodinated, photoactivatable LPS probe, we have recently identified an 80-kilodalton LPS-specific binding protein on murine B lymphocytes. We now have extended these studies to determine if other mammalian species, as well as representative endotoxin-resistant species (frog and chicken), have a similar LPS-binding protein. We have identified what appears to be a relatively conserved 80-kilodalton LPS-binding protein on mononuclear cells of all mammalian species tested. However, both frog and chicken leukocytes failed to show the presence of a similar LPS-binding protein. It is possible that the presence of specific LPS-binding proteins may be important for endotoxin sensitivity of most mammalian species.
A theory of mastery

Mastery is a human response to difficult or stressful circumstances in which competency, control, and dominion have been gained over the experience of stress. The goal of the theory of mastery is to explain how individuals who experience illness or other stressful health conditions may emerge, not demoralized and vulnerable, but healthy and possibly stronger. The human response to stress is fundamentally an existential problem. As such, the theory of mastery has philosophic as well as conceptual roots.
Elements of dynamics VI: the dynamic unconscious and unconscious dynamics.

The dynamic unconscious remains in contention in cognitive psychology. Academic settings may not provide the compelling evidence of unconscious dynamics regularly experienced by dynamic psychiatrists, psychoanalysts, and other physicians, including neurologists treating psychogenic motor disorders in the movement disorder clinic. An origin of unconscious motor expression is postulated in the intermodal connectivity of neuromental agencies, extending an idea that originated in Freud's (1950/1966) "Project for a Scientific Psychology. " Motoric alexithymia is contrasted with synesthesia. Other examples of unconscious psychodynamics of everyday life are readily found in sexual expression. Dynamic pressures that render processes unconscious may also originate interpersonally. Illustrations are drawn from cultural influence, peer and parental pressure, sports competition, military combat, and reactions to dangerous predators.
Effects of Chronic Ochratoxin A Exposure on p53 Heterozygous and p53 Homozygous Mice

Exposure to the mycotoxin ochratoxin A (OTA) causes nephropathy in domestic animals and rodents and renal tumors in rodents and poultry. Humans are exposed to OTA by consuming foods made with contaminated cereal grains and other commodities. Management of human health risks due to OTA exposure depends, in part, on establishing a mode of action (MOA) for OTA carcinogenesis. To further investigate OTA’s MOA, p53 heterozygous (p53+/−) and p53 homozygous (p53+/+) mice were exposed to OTA in diet for 26 weeks. The former are susceptible to tumorigenesis upon chronic exposure to genotoxic carcinogens. OTA-induced renal damage but no tumors were observed in either strain, indicating that p53 heterozygosity conferred little additional sensitivity to OTA. Renal changes included dose-dependent increases in cellular proliferation, apoptosis, karyomegaly, and tubular degeneration in proximal tubules, which were consistent with ochratoxicosis. The lowest observed effect level for renal changes in p53+/− and p53+/+ mice was 200 μg OTA/kg bw/day. Based on the lack of tumors and the severity of renal and body weight changes at a maximum tolerated dose, the results were interpreted as suggestive of a primarily nongenotoxic (epigenetic) MOA for OTA carcinogenesis in this mouse model.