Miracle-dz/UniFAR-FTUs huggingface dataset:
Results of a Second-generation Constrained Condylar Prosthesis in Complex Primary and Revision Total Knee Arthroplasty: A Mean 5.5-Year Follow-up

Background:The application of second-generation constrained condylar knee (CCK) prostheses has not been widely studied. This retrospective study was carried out to evaluate the clinical and radiographic outcomes of a second-generation CCK prosthesis for complex primary or revision total knee arthroplasty (TKA). Methods:In total, 51 consecutive TKAs (47 patients) were performed between June 2003 and June 2013 using second-generation modular CCK prostheses. The follow-up was conducted at 3rd day, 1st, 6th, and 12th months postoperatively and later annually. Anteroposterior (AP), lateral, skyline, and long-standing AP radiographs of the affected knees were taken. The Hospital for Special Surgery (HSS) Knee Score, the Knee Society Knee Score (KSKS), the Knee Society Function Score (KSFS), and range of motion (ROM) were also recorded. Heteroscedastic two-tailed Student's t-tests were used to compare the HSS score and the Knee Society score between primary and revision TKAs. A value of P < 0.05 was considered statistically significant. Results:Four knees (two patients) were lost to follow-up, and 47 knees (31 primary TKAs and 16 revision TKAs) had a mean follow-up time of 5.5 years. The mean HSS score improved from 51.1 ± 15.0 preoperatively to 85.3 ± 8.4 points at the final follow-up (P < 0.05). Similar results were observed in terms of the KSKS and KSFS, which improved from 26.0 ± 13.0 to 80.0 ± 12.2 and from 40.0 ± 15.0 to 85.0 ± 9.3 points, respectively (P < 0.05). No significant difference in the HSS, KSKS, KSFS, or ROM was found between primary and revision TKAs (P > 0.05). Two complications were observed in the revision TKA group (one intraoperative distal femur fracture and one recurrence of infection) while one complication (infection) was observed in the primary TKA group. No prosthesis loosening, joint dislocation, patella problems, tibial fracture, or nerve injury were observed. Radiolucent lines were observed in 4% of the knees without progressive osteolysis. Conclusions:Second-generation modular CCK prostheses are a safe and practical treatment for both primary and revision knees that cannot be balanced. However, further studies focusing on different types of constrained prostheses are required to validate these results.
Prospective teachers’ perceptions of instrumentality, boredom coping strategies, and four aspects of engagement

This study examined the mediating roles of prospective teachers’ boredom coping strategies (i.e. cognitive-approach, behavioral-approach, cognitive-avoidance, and behavioral-avoidance strategies) in the relationships between their perceptions of instrumentality and four aspects of engagement (i.e. agentic engagement, behavioral, engagement, emotional engagement, and cognitive engagement). A total of 521 prospective teachers participated voluntarily in the study. In addition to the latent factor and observed factor correlation analyses, a series of structural equation modeling analyses were conducted in order to examine the mediating roles of boredom coping strategies. The results demonstrated that perceived instrumentality, boredom coping strategies with the exception of cognitive-avoidance orientation, and four aspects of engagement were significantly related to each other. The results also showed that the relationships between perceived instrumentality and agentic engagement, behavioral engagement, emotional engagement, and cognitive engagement were slightly, but significantly mediated by cognitive-approach orientation. Implications for teacher education and directions for future studies were also discussed in the present study.
CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite

The costimulatory signal provided to T cells through CTLA-4-ligand interactions is required for T cell activation resulting in increased interleukin 2 (IL-2) production in vitro, but its role in the production of IL-4 and other cytokines is unclear and few in vivo studies have been performed to confirm results of in vitro experiments. We have examined the in vivo effects of blocking CTLA-4 ligands on the T helper cell 2 (Th2)-associated mucosal immune response that follows oral infection of mice with the nematode parasite, Heligmosomoides polygyrus. CTLA-4Ig administration inhibited H. polygyrus-induced increases in mesenteric lymph node (MLN) B cell major histocompatibility complex class II expression and size and T cell- derived IL-4 gene expression. In addition, CTLA-4 immunoglobulin (Ig) partially blocked increased IL-3, IL-5, and IL-9 cytokine gene expression in Peyer's patch (PP) and MLN 8 d after primary inoculation of mice with the parasite. Increases in the number of IL-4- but not IL- 5-secreting cells were also inhibited by CTLA-4Ig. H. polygyrus-induced elevations in serum IgE levels but not blood eosinophils, were markedly inhibited by CTLA-4Ig. These results suggest that stimulation of CD28 and/or CTLA-4 is required for T cell priming leading to IL-4 cytokine production, B cell activation, and IgE secretion during a Th2-like, mucosal immune response to a nematode parasite.
The clinical usefulness of the preoperative bleeding time.

OBJECTIVES To determine the clinical utilization of the Simplate bleeding time test as a preoperative screen, to examine the clinical utilization of the bleeding time test by multiple surgical services, and to correlate the indicators of bleeding risk (bleeding history, thrombocytopenia, prolonged prothrombin time/activated partial thromboplastin time, increased creatinine, and medications known to interfere with platelet function) with the bleeding time and the occurrence of clinically significant perioperative bleeding. DESIGN Retrospective data analysis. SETTING A large tertiary-care hospital. PATIENTS One hundred sixty-seven consecutive surgical patients tested for preoperative bleeding time. MAIN OUTCOME MEASURES The occurrence of clinically significant perioperative bleeding and the positive and negative predictive value of the preoperative screening bleeding time test. RESULTS Patients with a positive bleeding history were more likely to have an abnormal bleeding time (P = .04), but there was no statistically significant association between patients with an abnormal bleeding time and the other indicators of bleeding risk examined or the occurrence of clinically significant perioperative bleeding. The positive predictive value of the preoperative bleeding time was 5%, and the negative predictive value was 95%. CONCLUSIONS Screening for preoperative bleeding time is not a reliable test for assessing the risk of clinically significant perioperative bleeding and should not be used for this purpose.
β‐Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo

Microglia are the primary immune cells in the central nervous system. Microglia typically exist in a ‘resting’ state in the healthy brain, with ramified processes dynamically exploring the surrounding microenvironment. They become ‘activated’ under pathological conditions with marked changes in morphology. However, the regulation of their morphology dynamics remains poorly understood. Here, using in vivo time‐lapse imaging and three‐dimensional morphology analysis of microglia in intact zebrafish larvae, we found that β‐arrestin1, a multifunctional protein involved in various signal transductions, cell‐autonomously regulated the microglial morphology. Knockdown of β‐arrestin1 increased the volume size and process number of microglia but reduced the deformation speed in the resting state. Meanwhile, β‐arrestin1 down‐regulation led to a high frequency of phagocytic behaviour of microglia. These defects were partially rescued by over‐expressing human β‐arrestin1 in microglia. Our study indicated that microglial dynamics in the resting state can be regulated cell‐autonomously by β‐arrestin1 signalling.
Experience in Continuous analytics as a Service (CaaaS)

Mobile applications, such as those on WebOS, increasingly depend on continuous analytics results of real-time events, for monitoring oil & gas production, watching traffic status and detecting accident, etc, which has given rise to the need of providing Continuous analytics as a Service (CaaaS). While representing a paradigm shift in cloud computing, CaaaS poses several challenges in scalability, latency, time-window semantics, transaction control and result-set staging. A data stream is infinite thus can only be analyzed in granules. We propose a continuous query model over both static relations and dynamic streaming data, which allows a long-standing SQL query instance to run cycle by cycle, each cycle for a chunk of data from the data stream, using a cut-and-rewind mechanism. We further support the cycle-based transaction model with cycle-based isolation and visibility, for delivering analytics results to the clients continuously while the query is running. To have the continuously generated analytics results staged efficiently, we developed the table-ring and label switching mechanism characterized by staging data through metadata manipulation without physical data moving and copying. To scale-out analytics computation, we support both parallel database based and network distributed Map-Reduce based infrastructure with multiple cooperating engines. We have built the proposed infrastructure by extending the PostgreSQL engine. We tested the throughput and latency of this service based on a well-known stream processing benchmark; the results show that the proposed approach is highly competitive. Our experiments indicate that the database technology can be extended and applied to real-time continuous analytics service provisioning.
Validity of spirometry performed online

Spirometry is essential for the diagnosis and management of common respiratory diseases. However, its use and quality are low in primary care. An important reason for this is the technical difficulty in performing conventional spirometry. If high-quality spirometry could be performed online, from the pulmonary function laboratory in hospitals, most of the technical problems could be solved. The aim of the present study was to compare spirometries performed online by remote technicians with conventional spirometry. This was a controlled, randomised crossover study of 261 patients referred from primary care centres for pulmonary consultation. They were randomised to undergo either conventional or online spirometry. The technician, located remotely, controlled the spirometer computer. Using a teleconference link, the technician guided the patient through the spirometry. The comparison between conventional and online spirometries was performed on intention to treat and per protocol bases for spirometric values and quality criteria. Agreement between the two spirometric methods was assessed with a Bland–Altman plot. A subpopulation of off-range patients was also characterised. Finally, intra- and interobserver agreement was evaluated using the intraclass correlation coefficient. No clinically significant differences were seen between the online and conventional spirometric values in both the intention to treat and per protocol analyses. The agreement in Bland–Altman analysis was poorer for intention to treat than for the per protocol analysis. The latter had a lower percentage of off-range patients and high agreement to determine abnormal spirometry in the off-range group. Conventional spirometry had a higher percentage of patients with spirometric quality criteria although the quality criteria difference was only 5.9%, when both procedures were the first to start. Very good agreement was found between intra- and interobserver reliability. Spirometry performed online from a hospital can be an adequate alternative to conventional spirometry for primary care centres.
Hepatitis C Virus Persistence after Spontaneous or Treatment-Induced Resolution of Hepatitis C Tram

Hepatitis C Virus Persistence after Spontaneous or Treatment-Induced Resolution of Hepatitis C Tram N. Q. Pham, Sonya A. MacParland, Patricia M. Mulrooney, Helen Cooksley, Nikolai V. Naoumov, and Tomasz I. Michalak* Molecular Virology and Hepatology Research, Division of Basic Medical Science, and Division of Pathology, Faculty of Medicine, Memorial University, St. John’s, Newfoundland, Canada, and Institute of Hepatology, University College London, London, England
An illness behavior view on coping with diabetes

An epidemic of obesity and type 2 diabetes is in progress across the world, and the prevalence of diabetes has been projected to rise from 171 million in 2000 to 366 million in 2030 (Wild, Roglic, Green, Sicree, & King, 2004). Diabetes mellitus is a chronic disease associated with a significantly increased risk of morbidity due to macroand microvascular complications. Intensive treatment of glycemia, blood pressure, and lipids has been shown to delay the onset and reduce the progression of these complications (Marks & Raskin, 2000). In order to postpone complications, the diabetes patient is expected to induce healthy eating habits, perform regular physical activity, frequently monitor blood glucose, keep control on body weight, and take medications as prescribed. On top of that, existential questions arise, including worries about future complications and about the effectiveness of the treatment. This combination of self-management demands and high emotional distress may lead to feelings of burnout, and negative emotions such as anger, depression, and anxiety are common among diabetes patients and are also associated with poorer self-care behavior and metabolic control. A vicious circle may easily develop (Peyrot et al., 2005). This issue of the IJBM highlights the psychological aspects of having diabetes in a miniseries of four separate articles. In the first article, by Paddison, Alpass, and Stephens, the relationships between psychological aspects of diabetes and two diabetic outcomes, glycemic control and quality of life, are investigated. Using the common sense model (CSM) of illness self-regulation (Leventhal, Leventhal, & Contrada, 1998) as the conceptual framework, the authors demonstrate that the psychology surrounding the diabetes illness explained as much of the differences in glycemic control between subjects as the combination of disease duration, body mass index, and treatment regimen. Especially, fear for future complications and lack of knowledge about the disease, e.g.,
Introduction: morality as family practice

A universal function of the family is to raise children to think and feel that resonate with notions of morality that relate to social situations, sp to expected and preferred modes of participation in these situations. As notes, ‘[N]one of the moral virtues arises in us by nature . [R]athe adapted by nature to receive them, and are made perfect by habit’ (Aristo [4th century BCE]: 26). That is, children are born with a capacity for a knowledge and morality, but the flourishing of these qualities relies upon experiences with intimates. The prime intimate social unit is the famil members ideally provide secure environments that promote an openness about how one should treat other people, build social relationships, ena identities, and at the same time how one should apprehend and creative figure objects in the world. This is a tall order for families, and yet across the world’s societies, rarel ily members reflect upon and strategize about how to raise a moral, sent knowledgeable child beyond selection of and reliance upon children’s religious organizations, and other institutions outside the family. Yet, as th collected in this volume indicate, morality is embedded in and is an ou everyday family practices. The flow of social interactions involving ch imbued with implicit and explicit messages about right and wrong, be worse, rules, norms, obligations, duties, etiquette, moral reasoning, virt acter, and other dimensions of how to lead a moral life. While philosop bate the essence of morality, anthropologists and sociologists the socio configuration of morality, and psychologists the developmental progre morality, there is surprisingly little research on how morality is ena socialized through family interactions involving children. The presen provides five accounts of children’s immersion experiences in munda interactions with parents, which are imbued with moral expectations an ings and which apprentice children into moral life-worlds. 10.1177/ 0957926507069451
A Hybrid Grey Relational Analysis and Nondominated Sorting Genetic Algorithm-II for Project Portfolio Selection

Project selection and formation of an optimal portfolio of selected projects are among the main challenges of project management. For this purpose, several factors and indicators are simultaneously examined considering the terms and conditions of the decision problem. Obviously, both qualitative and quantitative factors may influence the formation of a portfolio of projects. In this study, the projects were first ranked using grey relational analysis to form an optimal portfolio of projects and to create an expert system for the final project selection. Because of the fuzzy nature of the environmental risk of each project, the environmental risk was predicted and analyzed using the fuzzy inference system and failure mode and effect analysis based on fuzzy rules. Then, the rank and risk of each project were optimized using a two-objective zero-one mathematical programming model considering the practical constraints of the decision problem through the nondominated sorting genetic algorithm-II (NSGA-II). A case study was used to discuss the practical methodology for selecting a portfolio of projects.
Server JavaScript DOM User

With increasing amounts of data available on the web and a diverse range of users interested in programmatically accessing that data, web automation must become easier. Automation helps users complete many tedious interactions, such as scraping data, completing forms, or transferring data between websites. However, writing web automation scripts typically requires an expert programmer because the writer must be able to reverse engineer the target webpage. We have built a record and replay tool, Ringer, that makes web automation accessible to non-coders. Ringer takes a user demonstration as input and creates a script that interacts with the page as a user would. This approach makes Ringer scripts more robust to webpage changes because user-facing interfaces remain relatively stable compared to the underlying webpage implementations. We evaluated our approach on benchmarks recorded on real webpages and found that it replayed 4x more benchmarks than a state-of-the-art replay tool.
To Shift or Not to Shift

MANY a high school orchestra violinist has pondered this question while reading concert or contest numbers for the first time, or while studying his part preparatory to tryouts. His degree of accuracy and his quickness of response to this will bring either joy or dismay to the heart of the director. Indeed, there may be a few directors who have raised their eyebrows in seeking this answer which means so much to the effective playing of their string sections. One ventures to include directors because there may be some who are primarily band men or vocalists, and, while they may know the effects they want from the strings, they are on slightly unfamiliar ground when confronted with certain problems of violin technique such as shifting in all its many uses and aspects. No one will deny that this very intimate part of a violinist's equipment can be learned best by actually doing it with one's own bow and fingers. Even though the orchestra director may lack this intimate acquaintance with the problem of shifting, he may learn some things by observation, while others will become clear only by gaining some knowledge of the general principles underlying this important part of string technique. In a brief attempt to shed some light on this problem we will leave out of the discussion bow technique-which is the ability to play the different styles of bowing such as martele, staccato, spiccato, etc.-and the skill necessary in playing the varied rhythmical patterns which are present on every page of orchestra music. Back of these skills is the ability to co6rdinate the left-hand fingers with the movements of the bow. This discussion presupposes this ability. The sum of all these bow and left-hand skills plus the use of the positions is the problem of shifting and of the portamento.
The State of the Art: Object Retrieval in Paintings using Discriminative Regions

The objective of this work is to recognize object categories (such as animals and vehicles) in paintings, whilst learning these categories from natural images. This is a challenging problem given the substantial differences between paintings and natural images, and variations in depiction of objects in paintings. We first demonstrate that classifiers trained on natural images of an object category have quite some success in retrieving paintings containing that category. We then draw upon recent work in mid-level discriminative patches to develop a novel method for reranking paintings based on their spatial consistency with natural images of an object category. This method combines both class based and instance based retrieval in a single framework. We quantitatively evaluate the method over a number of classes from the PASCAL VOC dataset, and demonstrate significant improvements in rankings of the retrieved paintings over a variety of object categories.
OrMiS: a tabletop interface for simulation-based training

This paper presents the design of OrMiS, a tabletop application supporting simulation-based training. OrMiS is notable as one of the few practical tabletop applications supporting collaborative analysis, planning and interaction around digital maps. OrMiS was designed using an iterative process involving field observation and testing with domain experts. Our key design insights were that such a process is required to resolve the tension between simplicity and functionality, that information should be displayed close to the point of the user's touch, and that collaboration around maps cannot be adequately solved with a single form of zooming. OrMiS has been evaluated by domain experts and by officer candidates at a military university.