Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction.

CONTEXT Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF). OBJECTIVE To study prospectively the association between nonfasting plasma homocysteine and incidence of CHF. DESIGN, SETTING, AND PARTICIPANTS Community-based prospective cohort study of 2491 adults (mean age 72 years, 1547 women) who participated in the Framingham Heart Study during the 1979-1982 and 1986-1990 examinations and were free of CHF or prior myocardial infarction (recognized or unrecognized) at baseline. MAIN OUTCOME MEASURE Incidence of a first episode of CHF during an 8-year follow-up period. RESULTS During follow-up, 156 subjects (88 women) developed CHF. In multivariable analyses controlling for established risk factors for CHF including the occurrence of myocardial infarction (recognized or unrecognized) during follow-up, plasma homocysteine levels higher than the sex-specific median value were associated with an adjusted hazards ratio for heart failure of 1.93 in women (95% confidence interval, 1.19-3.14) and 1.84 in men (95% confidence interval, 1.06-3.17). The relation of plasma homocysteine levels to CHF risk was more continuous in women than in men. In analyses restricted to participants without any manifestation of coronary heart disease at baseline, the association of plasma homocysteine levels with risk of CHF was maintained in men and women. CONCLUSIONS An increased plasma homocysteine level independently predicts risk of the development of CHF in adults without prior myocardial infarction. Additional investigations are warranted to confirm these findings.
Has the Information Content of Quarterly Earnings Announcements Declined in the Past Three Decades

This paper examines changes in the information content of earnings over the past three decades using the two metrics from Beaver [1968]: abnormal trading volume and abnormal return volatility. We find no evidence of a decline in the information content of earnings announcements over the past three decades, as measured by both abnormal trading volume and return volatility around quarterly earnings announcements. If anything, our results suggest an increase over time in the informativeness of quarterly earnings announcements. Variables reflecting changes in firm‐specific factors account for a portion of the observed increase.
Demographic genetics of the American beech, Fagus grandifolia. II. Genet substructure of populations for the Blue Ridge, Piedmont and the Great Smoky Mountains

Populations of American beech in Virginia and the Great Smoky Mountain National Park in Tennessee and North Carolina were investigated for demographic genetic substructurings. Two Virginia populations, one on the Blue Ridge (WG1) and the other on the Piedmont (WG2) occur over an elevational gradient of several hundreds meters. One of the Great Smoky Mountain populations (GS1) was in a ‘beech gap’ and the other (GS2) in a ‘cove forest’ along a creek. The populations in the Great Smoky Mountain National Park were only separated by a few hundred meters in elevation, but both on the same physiographic province. The populations had two growth forms. Trees produced extensive root suckers at WG1, GS1 and GS2, but WG2 had no root suckers and all individuals had obviously been established from seeds. A total of 1335 shoots were mapped at the four sites, their size measured [diameter at breast height (DBH) or diameter at ground height (DGH)], and genotypes were determined for each locus using allozyme analysis. FIS among five different size-classes revealed an excess of homozygotes in WG1, GS1 and GS2, and an excess of heterozygotes in WG2. The offshoot formation from root suckers obviously contributed to the abundance of intermediate size-classes in WG1, GS1 and GS2. Exceedingly localized patchiness of different multilocus genotypes reveals genetic clustering of shoots that have obviously originated from root suckers in WG1, GS1 and GS2. The Piedmont population (WG2), on the other hand, showed loose localization of genetically related trees at a scale of 35–40 m in area, suggesting broader ranges of pollen and seed dispersal. The data are discussed in the light of the differences in growth form and mode of reproduction, and also in relation to the post-glacial migration and the current geographic distribution of the species.
RFLP mapping of genes conferring complete and partial resistance to blast in a durably resistant rice cultivar.

Moroberekan, a japonica rice cultivar with durable resistance to blast disease in Asia, was crossed to the highly susceptible indica cultivar, CO39, and 281 F7 recombinant inbred (RI) lines were produced by single seed descent. The population was evaluated for blast resistance in the greenhouse and the field, and was analyzed with 127 restriction fragment length polymorphism (RFLP) markers. Two dominant loci associated with qualitative resistance to five isolates of the fungus were tentatively named Pi-5(t) and Pi-7(t). They were mapped on chromosomes 4 and 11, respectively. To identify quantitative trait loci (QTLs) affecting partial resistance, RI lines were inoculated with isolate PO6-6 of Pyricularia oryzae in polycyclic tests. Ten chromosomal segments were found to be associated with effects on lesion number (P < 0.0001 and LOD > 6.0). Three of the markers associated with QTLs for partial resistance had been reported to be linked to complete blast resistance in previous studies. QTLs identified in greenhouse tests were good predictors of blast resistance at two field sites. This study illustrates the usefulness of RI lines for mapping a complex trait such as blast resistance and suggests that durable resistance in the traditional variety, Moroberekan, involves a complex of genes associated with both partial and complete resistance.
Social Jealousy and Stigma - Negative Externalities of Social Assistance Payments in Germany

This paper examines the role of social assistance payments (SAP or Sozialhilfe) in deter- mining levels of life satisfaction in Germany using the SOEP 1995-2004. We flnd strong evidence that individuals in Germany are negatively in∞uenced by increased SAP payments controlling for income, whether or not they actually receive such payments (stigma and social jealousy). While there are obvious beneflts to making SAP to those needy, there are substantial negative externali- ties experienced by those who neither receive SAP nor qualify (counterfactual SAP). Furthermore, these negative efiects are even stronger for those who do receive beneflts (stigma) suggesting that social jealousy and stigma are a force to be reckoned with when evaluating social policy. We show that the added beneflts of increasing SAP are reduced by 50 to 100% because of social jealousy and stigma costs, whereas child beneflts (Kindergeld) are seen to enhance life satisfaction over and above a simple income efiect. Further, own-earned income, over and above the SAP subsistence level is valued much higher than transfer payments at the SAP subsistence level, suggesting a policy focus on increasing employment integration efiorts for SAP recipients as opposed merely to providing SAP transfers.
Draft Genome Sequence of the Mycobacterium tuberculosis Clinical Isolate C2, Belonging to the Latin American–Mediterranean Family

ABSTRACT Tuberculosis remains a major infectious disease in Taiwan. Here we present the draft genome sequence of the Mycobacterium tuberculosis C2 strain, belonging to the Latin American–Mediterranean lineage. The draft genome sequence comprises 4,453,307 bp with a G+C content of 65.6%, revealing 4,390 coding genes and 45 tRNA genes.
Interview with Don Norman

APPROPRIATING: We work out how a new experience fits with other experiences we have had and with our sense of self. This involves making an experience our own by relating it to our sense of self, our personal history, and our anticipated future. We may decide against buying over the Internet because we feel strongly about supporting local shops. Or we may modify the strength of our feelings about local shops because of the satisfaction of shopping on the Internet.
On run time libraries and hierarchical symbiosis

Run time libraries (RTL) in genetic programming (GP) represent a scenario in which individuals evolved under an earlier independent evolutionary run can be potentially incorporated into a following GP run. To date, schemes for exploiting the RTL metaphor have emphasized syntactic over behavioural approaches. Thus, instructions are added to the later run such that the previous code can be explicitly indexed. In this work we demonstrate how the RTL concept is naturally supported by adopting a symbiotic framework for coevolution. Under the Pinball reinforcement learning task, we demonstrate how the initial RTL can be coevolved within a simpler formulation of the task and then used as the basis for providing solutions to a more difficult target task under the same domain. The resulting solutions are stronger than an RTL as coevolved against the target task alone or symbiosis as evolved without support for RTL.
Isolation and identification of amoeba-resisting bacteria from water in human environment by using an Acanthamoeba polyphaga co-culture procedure.

Amoeba-resisting bacteria (ARB) such as Legionella spp. are currently regarded as potential human pathogens living in the environment. To detect ARB from both human and environmental samples, co-culture with amoebae has been demonstrated as an efficient tool. However, using this procedure, mostly water from cooling towers and hospital water supplies have been investigated as the possible reservoir of ARB. In the present study, we studied ARB population in 77 environmental water samples including rivers, fountains, lakes and domestic wells in the south of France. As a result, a total of 244 isolates corresponding to 89 different species of ARB, but not Legionella spp. , were identified. Ability to grow within and/or to be lytic for amoebae was revealed for the first time for several human pathogens. Six isolates are likely to be the members of a new or uncharacterized genus/species. An anaerobic bacterium, Clostridium frigidicarnis was demonstrated to be lytic for amoebae. This preliminary work demonstrates that the water environment in the vicinity of humans is a reservoir of ARB, including well-known pathogens for which amoebae and/or water was not recognized earlier as a possible reservoir.
A framework for evaluating motion segmentation algorithms

There have been many proposals for algorithms segmenting human whole-body motion in the literature. However, the wide range of use cases, datasets, and quality measures that were used for the evaluation render the comparison of algorithms challenging. In this paper, we introduce a framework that puts motion segmentation algorithms on a unified testing ground and provides a possibility to allow comparing them. The testing ground features both a set of quality measures known from the literature and a novel approach tailored to the evaluation of motion segmentation algorithms, termed Integrated Kernel approach. Datasets of motion recordings, provided with a ground truth, are included as well. They are labelled in a new way, which hierarchically organises the ground truth, to cover different use cases that segmentation algorithms can possess. The framework and datasets are publicly available and are intended to represent a service for the community regarding the comparison and evaluation of existing and new motion segmentation algorithms.
Properties of High Frequency DAX Returns: Intraday Patterns, Jumps and their Impact on Subsequent Volatility

This paper analyzes the behavior of the German DAX index intraday returns. We devote particular attention to three related empirical issues. First we provide an up-to-date characterization of the DAX intraday volatility patterns. They are mostly W-shaped with peaks at the opening, at 2.30pm and before the closing. We find some evidence suggesting that the implied volatility also follows some deterministic patterns over the trading day. Second we identify jumps in DAX returns. On jump days, they account on average for 15% to 25% of the daily variance. Jumps also tend to cluster and are not evenly distributed throughout the trading day. Third we estimate the impact of a price jump on volatility. We consider different proxies for volatility: absolute returns, implied volatility and realized volatility. Our results indicate that negative jumps trigger a strong upward correction in volatility. This correction starts just after a jump occured and persists during up to 25 minutes. On the other hand, positive jumps seem to have a much less significant impact on volatility. These results hold for all volatility proxies but they are more significant when we consider the implied volatility.
Metapopulation Structure Favors Plasticity over Local Adaptation

We describe a model for the evolutionary consequences of plasticity in an environmentally heterogeneous metapopulation in which specialists for each of two alternative environments and one plastic type are initially present. The model is similar to that proposed by Moran (1992) but extends her work to two sites. We show that with migration between sites the plastic type is favored over local specialists across a broad range of parameter space. The plastic type may dominate or be fixed even in an environmentally uniform site, and even if the plasticity has imperfect accuracy or bears some cost such that a local specialist has higher fitness in that site, as long as there is some migration between sites with different distributions of environmental states. These results suggest that differences among taxa in dispersal and hence realized migration rates may play a heretofore unrecognized role in their patterns of adaptive population differentiation. Migration relaxes the thresholds for both environmental heterogeneity and accuracy of plastic response above which plasticity is favored. Furthermore, small changes in response accuracy can dramatically and abruptly alter the evolutionary outcome in the metapopulation. A fitness cost to plasticity will substantially reduce the range of conditions in which the plastic type will prevail only if the cost is both large and global rather than environment specific.
Pulmonary clearance kinetics and extrapulmonary translocation of seven titanium dioxide nano- and submicron materials following intratracheal administration in rats

Abstract We evaluated and compared the pulmonary clearance kinetics and extrapulmonary translocations of seven titanium dioxide (TiO2) nano- and submicron particles with different characteristics, including size, shape and surface coating. Varying doses of TiO2 nano- and submicron particles dispersed in 0.2% disodium phosphate solution were intratracheally administered to male F344 rats. The rats were euthanized under anesthesia for 3, 28 and 91 days after administration. Ti levels in pulmonary and various extrapulmonary organs were determined using inductively coupled plasma-sector field mass spectrometry (ICP-SFMS). The lungs, including bronchoalveolar lavage fluid (BALF), contained 55–89% of the administered TiO2 dose at 3 days after administration. The pulmonary clearance rate constants, estimated using a one-compartment model, were higher after administration of 0.375–2.0 mg/kg body weight (bw) (0.016–0.020/day) than after administration of 3.0–6.0 mg/kg bw (0.0073–0.013/day) for six uncoated TiO2. In contrast, the clearance rate constant was 0.011, 0.0046 and 0.00018/day following administration of 0.67, 2.0 and 6.0 mg/kg bw TiO2 nanoparticle with Al(OH)3 coating, respectively. Translocation of TiO2 from the lungs to the thoracic lymph nodes increased in a time- and dose-dependent manner. Furthermore, the translocation of TiO2 from the lungs to the thoracic lymph nodes after 91 days was higher when Al(OH)3 coated TiO2 was administered (0.93–6.4%), as compared to uncoated TiO2 (0.016–1.8%). Slight liver translocation was observed (<0.11%), although there was no clear trend related to dose or elapsed time. No significant translocation was observed in other organs including the kidney, spleen and brain.
Dietary, social, and environmental determinants of obesity in Kenyan women

Aim: To assess the determinants of overweight and obesity in Kenyan women considered to be undergoing the nutrition transition. Methods: A nationally representative sample of women (n = 1008) was randomly drawn. Weight, height, waist, and hip circumference were measured. A 24-hour dietary recall was conducted with each participant and a socio-demographic questionnaire completed. Data was analysed by age, education, location, and socioeconomic status. Risk for obesity was calculated while adjusting for age and location. Results: Overweight and obesity (BMI ≥ 25 kg/m2) were highly prevalent in Kenya (43.3%). Urbanisation appears to be an important determinant of obesity since obesity was most prevalent in urban women in the high income group. Women in the high income group (7278 kJ) and in urban areas (7049 kJ) had the highest mean energy intakes. There were also significant urban/rural and income differences in the contribution of macronutrients to energy intake. Total fat intake was 34.5% of energy (E) in urban areas and 29.7% E in rural areas; while carbohydrates contributed 69.9% E in rural areas and 57.4% E in urban areas (p < 0.0001). Overweight was significantly more likely in the highest income group; among households where room density was low; electricity or gas was used for cooking; and households had own tap and/or own flush toilet. Conclusions: This study suggests that urbanisation and its associated economic advancement as well as changes in dietary habits are among the most important determinants of overweight and obesity in Kenyan women.
Optimal Policy for a Reseller When the Supplier Offers a Temporary Reduction in Price

A common practice in product distribution is the case in which the supplier offers a temporary reduction in price. It is suggested in the literature that in such situations, the reseller may engage in forward buying (i.e., purchasing additional stock at the reduced price offered by the supplier for later sale at the regular selling price). In this paper, a model is formulated of the reseller's response when the supplier offers a temporary reduction in price. It is assumed that the market demand for the product is elastic with respect to the selling price the reseller sets. A procedure for determining the optimal response of the reseller is developed. The model presented in this paper can easily be adapted to the case in which the reseller faces a permanent increase in the price charged by the supplier.
Review article: Best practice management of common shoulder injuries and conditions in the emergency department (part 4 of the musculoskeletal injuries rapid review series)

Shoulder injuries are a commonly presenting complaint to the ED. In the absence of an obvious deformity, they can be difficult to assess and definitively diagnose because of the multiple structures that cause shoulder pain, the acuity and severity of pain and the lack of range of motion in the ED setting. The quality of ED care provided to patients with musculoskeletal shoulder pain is crucial to ensure the best possible outcomes for the patient. This rapid review investigated best practice for the assessment and management of common shoulder injuries and conditions in the ED. Databases were searched in 2017, including PubMed, CINAHL, EMBASE, TRIP and the grey literature, including relevant organisational websites. Primary studies, systematic reviews and guidelines published in English‐language in the past 12 years that addressed the acute assessment, management, follow‐up plan or prognosis were considered for inclusion. Data extraction of included articles was conducted, followed by quality appraisal to rate the level of evidence. The search revealed 1902 articles, of which 73 were included in the review (n = 12 primary articles, n = 49 systematic reviews and n = 12 guidelines). This rapid review provides clinicians who manage shoulder dislocations, fractures and soft tissue injuries in the ED a summary of the best available evidence to enhance the quality of care for optimal patient outcomes. There is strong evidence to support taking a thorough history and physical examination, with cautious use of special tests because of their poor diagnostic accuracy. Key points regarding the diagnosis and management of these injuries are provided.
The Stambaugh Bias in Panel Predictive Regressions

This paper analyzes predictive regressions in a panel data setting. The standard fixed effects estimator suffers from a small sample bias, which is the analogue of the Stambaugh bias in time-series predictive regressions. Monte Carlo evidence shows that the bias and resulting size distortions can be severe. A new bias-corrected estimator is proposed, which is shown to work well in finite samples and to lead to approximately normally distributed t-statistics. Overall, the results show that the econometric issues associated with predictive regressions when using time-series data to a large extent also carry over to the panel case. The results are illustrated with an application to predictability in international stock indices.
Preferences of the poor: market participation and asset management of poor households in sixteenth-century Holland

Our article aims to detect differences in behaviour towards the capital and land market of households of different sizes and levels of income. Participation in markets for real estate, capital, and ships was considerable, not only among middling and elite groups but also among the poor. Large households were most active in markets, incurring significantly greater debt. Poor households with a low supply of labour were relatively active, purchasing houses and ships, and incurring debts, possibly in order to cope with a lack of parental support. Middling-group households with a low supply of labour primarily sold houses and invested in the capital market, adjusting capital assets to declining labour supply at the end of their life cycle, thus creating cash rents to be able to survive old age. Copyright , Oxford University Press.