Miracle-dz/UniFAR-FTUs huggingface dataset:
Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors

The International Neuroblastoma Pathology Classification (International Classification), which was established in 1999, is significant prognostically and is relevant biologically for the evaluation and analysis of patients with neuroblastic tumors (NTs). MYCN amplification is a known molecular marker for aggressive progression of NTs. These have been used together as important prognostic factors to define risk groups for patient stratification and protocol assignment.
Client-Driven Content Extraction Associated with Table

The goal of the project is to extract content within table in document images based on learnt patterns. Real-world users i.e., clients first provide a set of key fields within the table which they think are important. These are first used to represent the graph where nodes are labelled with semantics including other features and edges are attributed with relations. Attributed relational graph (ARG) is then employed to mine similar graphs from a document image. Each mined graph will represent an item within the table, and hence a set of such graphs will compose a table. We have validated the concept by using a real-world industrial problem.
Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability*

Background: Human APOBEC3H is a mutation-inducing restriction factor for HIV-1 that exists as multiple haplotypes. Results: Two APOBEC3H haplotypes were biochemically characterized. Conclusion: An amino acid polymorphism between APOBEC3H haplotypes II and V alters their processivity, but not mutagenic ability. Dimerization is required for efficient processivity. Significance: APOBEC3H has redundant processive mechanisms enabling haplotypes to efficiently restrict HIV-1 but by distinct mechanisms. APOBEC3H is a deoxycytidine deaminase that can restrict the replication of HIV-1 in the absence of the viral protein Vif that induces APOBEC3H degradation in cells. APOBEC3H exists in humans as seven haplotypes (I–VII) with different cellular stabilities. Of the three stable APOBEC3H haplotypes (II, V, and VII), haplotypes II and V occur most frequently in the population. Despite APOBEC3H being a bona fide restriction factor, there has been no comparative biochemical characterization of APOBEC3H haplotypes. We characterized the ssDNA scanning mechanisms that haplotypes II and V use to search their ssDNA substrate for cytosine-containing deamination motifs. APOBEC3H haplotype II was able to processively deaminate multiple cytosines in a single enzyme-substrate encounter by using sliding, jumping, and intersegmental transfer movements. In contrast, APOBEC3H haplotype V exhibited diminished sliding and intersegmental transfer abilities but was able to jump along ssDNA. Due to an Asp or Glu at amino acid 178 differentiating these APOBEC3H haplotypes, the data indicated that this amino acid on helix 6 contributes to processivity. The diminished processivity of APOBEC3H haplotype V did not result in a reduced efficiency to restrict HIV-1 replication in single-cycle infectivity assays, suggesting a redundancy in the contributions of jumping and intersegmental transfer to mutagenic efficiency. Optimal processivity on ssDNA also required dimerization of APOBEC3H through the β2 strands. The findings support a model in which jumping can compensate for deficiencies in intersegmental transfer and suggest that APOBEC3H haplotypes II and V induce HIV-1 mutagenesis efficiently but by different mechanisms.
Compact State Machines for High Performance Pattern Matching

Pattern matching is essential to a wide range of applications such as network intrusion detection, virus scanning, etc. Pattern matching algorithms normally rely on state machines to detect predefined patterns. Recently, parallel pattern matching engines, based on ASICs, FPGAs or network processors, perform matching with multiple state machines. The state migration in the matching procedure incurs intensive memory accesses. Thus, it is critical to minimize the storage of state machines such that they can be fit in on-chip or other fast memory modules to achieve high-speed pattern matching. This paper proposes novel optimization techniques, namely state re-labeling and memory partition, to reduce state machine storage. The paper also presents architectural designs based on the optimization strategy. We evaluate our design using realistic pattern sets, and the results show state machine memory reduction up to 80.1%.
STUDI EKSPLORATIF PERILAKU KOPING PADA INDIVIDU DENGAN CEREBRAL PALSY

Penelitian ini bertujuan untuk mengetahui dan mengkaji lebih dalam bagaimana strategi koping, bentuk perilaku koping dan sumber koping yang dilakukan oleh individu dengan cerebral palsy. Informan penelitian diperoleh dengan teknik purposif, dengan karakteristik informan: Individu dengan cerebral palsy, tidak disertai retardasi mental, dan tidak disertai kecacatan lain. Teknik pengumpulan data yang digunakan wawancara mendalam, observasi dan dokumentasi. Hasil penelitian menunjukan dari 6 informan terdapat 5 informan yang menggunakan strategi problem focused coping dan 1 informan menggunakan emotional focused coping. Perilaku koping yang dilakukan adalah berusaha santai atau tidak terbebani dengan kondisi fisiknya serta merasa dirinya normal seperti orang lain. Sumber koping yang paling banyak digunakan adalah keyakinan positif dan dukungan sosial. Temuan menarik dalam penelitian ini adalah semua informan selalu memiliki "rasa syukur" atas kehidupannya meskipun mereka mengalami keterbatasan fisik. Kata kunci : Perilaku Koping, Individu dengan Cerebral Palsy This research aimed to investigated and examined deeply how the coping strategies, coping behavior and the source of coping conducted by individuals with cerebral palsy. Informants were obtained by purposive technique, with the characteristics of the informants: individuals suffer cerebral palsy without mental retardation, and other disabilities. Data collection techniques used in-depth interviews, observation and documentation.The results of this study indicated that 5 of 6 informants use problem focused coping strategies and one informant uses emotional focused coping. Coping behavior that used by informants are trying to relax or not being burdened by his physical condition and felt they are normal like everyone else. Source of the most widely coping uses by the sufferer is positive beliefs and social support. Interesting findings of the research revealed almost all the research informants always have a "sense of gratitude" for his life even though they have physical limitations due to cerebral palsy that they experienced. Keywords : Coping Behavior, Individual with Cerebral Palsy
Motion planning for camera movements

Moving a camera through a (virtual or real) environment is a complicated task. Often a user is given direct control of the camera. Such direct control is difficult for inexperienced users and results in rather ugly camera motions that easily lead to motion sickness. In this paper we describe a new technique for automatic generation of camera motion using motion planning techniques from robotics. We focus here on motion in virtual environments. In our approach the user simply specifies a required goal position (and orientation) using e.g. a map, and the system automatically computes a smooth, collision free motion from the current position and orientation to the required position (and orientation) that can be used by the camera. As preprocessing, the approach uses the probabilistic roadmap method to compute a roadmap through the environment. When a motion is required, a path is obtained from the roadmap which is then improved by various smoothing techniques to satisfy constraints from cinematography.
Barrels XII - Proceedings

E. Ahissar, M. Zacksenhouse, R. Sosnik and S. Haidarliu Possible encoding± decoding schemes in the vibrissal system: arc-based spatial coding and row-based temporal coding Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel and Faculty of Mechanical Engineering, Technion ± Israel Institute of Technology,
Maximum a posteriori linear regression for speaker recognition

Recently, using maximum likelihood linear regression (MLLR) transforms as the features for SVM based speaker recognition has been proposed. This can achieve performance comparable to that obtained with state-of-the-art approaches. In this paper, we focus on calculating the transforms based on a GMM universal background model (UBM). Rather than estimating the transforms using maximum likelihood criterion, we describe a new feature extraction technique for speaker recognition based on maximum a posteriori linear regression (MAPLR). This work is enriched by a proposed multi-class technique, which clusters the Gaussian mixtures into regression classes and estimates a different transform for each class. All the transforms of all the classes for a given utterance are concatenated into a supervector for SVM classification. Experiments on a NIST 2008 SRE corpus show that the speaker recognition system using MAPLR outperforms MLLR, and the multi-class approach can also bring significant gains for MAPLR system.
Innovations in learning : new environments for education

Contents: Foreword. Preface. Part I: Education Outside the Classroom. L. Schauble, D.B. Beane, G.D. Coates, L.M. W. Martin, P.V. Sterling, Outside the Classroom Walls: Learning in Informal Environments. L. Flower, Collaborative Planning and Community Literacy: A Window on the Logic of Learners. C. Juel, Learning to Learn from Effective Tutors. P. Pedraza, J. Ayala, Motivation as an Emergent Issue in an After-School Program in El Barrio. Part II: Learning Inside the Classroom. B. Warren, A.S. Rosebery, "This Question is Just Too, Too Easy! " Students' Perspectives on Accountability in Science. E.A. Silver, Moving Beyond Learning Alone and in Silence: Observations from the QUASAR Project Concerning Communication in Mathematics Classrooms. M. Resnick, Toward a Practice of "Constructional Design. " J. Minstrell, V. Stimpson, A Classroom Environment for Learning: Guiding Students' Reconstruction of Understanding and Reasoning. G.W. McDiarmid, Challenging Prospective Teachers' Understandings of History: An Examination of a Historiography Seminar. M. Lamon, T. Secules, A.J. Petrosino, R. Hackett, J.D. Bransford, S.R. Goldman, Schools for Thought: Overview of the Project and Lessons Learned from One of the Sites. A.L. Brown, J.C. Campione, Psychological Theory and the Design of Innovative Learning Environments: On Procedures, Principles, and Systems. Part III: Changing Environments for Education. H.M. Levin, Accelerated Schools After Eight Years. J.P. McDonald, Below the Surface of School Reform: Vision and Its Foes.
Recipes 2.0: building for today and tomorrow

The history of science gateway development has, in many ways, been a story of the ‘Haves’ vs. the ‘Have‐nots’. Large infrastructure projects led the way, building thick client portals to provide coherent interfaces to an incoherent environment. Contrast this with the way the modern Web is designed using light, front end components, and outsourcing much of the heavy lifting to a mash‐up of REST application programming interfaces, and it is easy to see why modern web applications can be prototyped and refined into stable products in the time it previously took thick client portals to do an initial release. This paper argues that a ‘build for today’ philosophy can lead to the rapid development of science gateways to serve the ‘Have‐nots’. With this philosophy in mind, we are presenting Gateway DNA, a set of responsive front end components built on top of the iPlant Agave application programming interfaces. This toolkit provides the boilerplate for rapid development of lightweight science gateways using only HTML, JavaScript, and CSS. Using Gateway DNA, developers can easily stand up new gateways or quickly add new functionality to existing ones. Copyright © 2014 John Wiley & Sons, Ltd.
Ánalisis de la fiabilidad de un cuestionario de motivaciones del voluntariado en SIDA

Reliability analysis of the Inventory of Motivations for AIDS Volunteerism. This study analyze the reliability of the Inventory of Motivations for AIDS Volunteerism and its factorial structure with a Spanish sample of 130 volunteers. Results show the high internal consistency of the Inventory of Motivations (0.9). The factorial results have revealed that this questionnaire shows a structure of five factores that explainthe 64.4% of the variance. This is consistent with the Functional Approach of the Motivation of Omoto and Snyder. However, some differences have appeared between both factorial structures, due to the different composition of the sample.
Getting the Most Out of Giving: Pursuing Concretely-Framed Prosocial Goals Maximizes Happiness

Across six field and laboratory experiments, participants given a concretely-framed prosocial goal (e.g., making someone smile, increasing recycling) felt happier after performing a goal-directed act of kindness than did those who were assigned a functionally similar, but more abstractly-framed, prosocial goal (e.g., making someone happy, saving the environment). This effect was driven by differences in the size of the gap between participants' expectations and reality: Compared to those assigned to pursue an abstractly-framed prosocial goal, those assigned to pursue a concretely-framed goal perceived that the actual outcome of their goal-directed efforts more accurately matched their expectations, causing them to experience a greater boost in personal happiness. Further, participants were unable to predict this effect, believing that pursuing abstractly-framed prosocial goals would have either an equal or greater positive impact on their own happiness.
The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome.

The only complete genome nucleotide sequences of measles virus (MeV) reported to date have been for the Edmonston (Ed) strain and derivatives, which were isolated decades ago, passaged extensively under laboratory conditions, and appeared to be nonpathogenic. Partial sequencing of many other strains has identified >/=15 genotypes. Most recent isolates, including those typically pathogenic, belong to genotypes distinct from the Edmonston type. Therefore, the sequence of Ed and related strains may not be representative of those of pathological measles circulating at that or any time in human populations. Taking into account these issues as well as the fact that so many studies have been based upon Ed-related strains, we have sequenced the entire genome of a recently isolated pathogenic strain, 9301B. Between this recent isolate and the classical Ed strain, there were 465 nucleotide differences (2.93%) and 114 amino acid differences (2.19%). Computation of nonsynonymous and synonymous substitutions in open reading frames as well as direct comparisons of noncoding regions of each gene and extracistronic regulatory regions clearly revealed the regions where changes have been permissible and nonpermissible. Notably, considerable nonsynonymous substitutions appeared to be permissible for the P frame to maintain a high degree of sequence conservation for the overlapping C frame. However, the cause and the effect were largely unclear for any substitution, indicating that there is a considerable gap between the two strains that cannot be filled. The sequence reported here would be useful as a reference of contemporary wild-type MeV.
The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus

An early consequence of brain energy deprivation is an increase in the frequency of spontaneous inhibitory and excitatory postsynaptic currents (sIPSCs and sEPSCs), which may disrupt neural information processing. This increase in spontaneous transmitter release has been reported to occur in calcium‐free solution and has been attributed either to calcium release from internal stores or to a direct effect of hypoxia on the transmitter release mechanism. Here we investigate the mechanism of the increase in sIPSC frequency that occurs in area CA1 of rat hippocampus during simulated ischaemia, by making patch‐clamp recordings from CA1 pyramidal neurones. When recording in whole‐cell mode, exposure to ischaemic solution increased the sIPSC frequency 30‐fold (to 49 Hz) after 5 min, and doubled the sIPSC amplitude. Ischaemic sIPSCs were action potential independent, vesicular in origin and, contrary to the results of earlier studies which did not buffer extracellular calcium to a low level, dependent on extracellular calcium. The properties of the ischaemic sIPSCs were not affected by depleting intracellular stores of calcium or by blocking the neuronal GABA transporter GAT‐1. Recording from neurones using gramicidin‐perforated patch‐clamping showed a 10‐fold smaller, more transient increase in sIPSC frequency during ischaemia, with no change of sIPSC amplitude, suggesting that whole‐cell clamp recording increases the ischaemia‐induced sIPSC rate and amplitude by controlling the intracellular milieu.
High-throughput mutation detection method to scan BRCA1 and BRCA2 based on heteroduplex analysis by capillary array electrophoresis.

BACKGROUND Scanning for mutations in BRCA1 and BRCA2 in a large number of samples is hampered by the large sizes of these genes and the scattering of mutations throughout their coding sequences. Automated capillary electrophoresis has been shown to be a powerful system to detect mutations by either single-strand conformation polymorphism or heteroduplex analysis (HA). METHODS We investigated the adaptation of gel-based HA of BRCA1 and BRCA2 to a fluorescent multicapillary platform to increase the throughput of this technique. We combined multiplex PCR, three different fluorescent labels, and HA in a 16-capillary DNA sequencer and tested 57 DNA sequence variants (11 insertions/deletions and 46 single-nucleotide changes) of BRCA1 and BRCA2. RESULTS We detected all 57 DNA changes in a blinded assay, and 2 additional single-nucleotide substitutions (1186 A>G of BRCA1 and 3624 A>G of BRCA2), previously unresolved by conformation-sensitive gel electrophoresis. Furthermore, different DNA changes in the same PCR fragment could be distinguished by their peak patterns. CONCLUSIONS Capillary-based HA is a fast, efficient, and sensitive method that considerably reduces the amount of "hands-on" time for each sample. By this approach, the entire coding regions of BRCA1 and BRCA2 from two breast cancer patients can be scanned in a single run of 90 min.
Crosstalk Models for Short VDSL2 Lines from Measured 30 MHz Data

In recent years, there has been a growing interest in hybrid fiber-copper access solutions, as in fiber to the basement (FTTB) and fiber to the curb/cabinet (FTTC). The twisted pair segment in these architectures is in the range of a few hundred meters, thus supporting transmission over tens of MHz. This paper provides crosstalk models derived from measured data for quad cable, lengths between 75 and 590 meters, and frequencies up to MHz. The results indicate that the log-normal statistical model (with a simple parametric law for the frequency-dependent mean) fits well up to MHz for both FEXT and NEXT. This extends earlier log-normal statistical modeling and validation results for NEXT over bandwidths in the order of a few MHz. The fitted crosstalk power spectra are useful for modem design and simulation. Insertion loss, phase, and impulse response duration characteristics of the direct channels are also provided.
NRC-Canada-2014: Detecting Aspects and Sentiment in Customer Reviews

Reviews depict sentiments of customers towards various aspects of a product or service. Some of these aspects can be grouped into coarser aspect categories. SemEval-2014 had a shared task (Task 4) on aspect-level sentiment analysis, with over 30 teams participated. In this paper, we describe our submissions, which stood first in detecting aspect categories, first in detecting sentiment towards aspect categories, third in detecting aspect terms, and first and second in detecting sentiment towards aspect terms in the laptop and restaurant domains, respectively.
Central [CNS] and Peripheral [Gastric Tissue] Selective Monitoring of Somatostatin (SRIF) with Micro-Sensor and Voltammetry in Rats: Influence of Growth Factors (GH, EGF)

Somatostatin (SRIF) is widely distributed throughout the body, and regulates the endocrine system via interactions with various hormones, including the pituitary growth hormone, the thyroid stimulating hormone and the majority of the hormones of the gastrointestinal tract. SRIF is present in the central nervous system (CNS), where it affects rates of neurotransmission, and is also reported to be active in the intestinal tract, with evidence that stressed rats present a significant decrease in antral somatostatin-like immunoreactivity (SLI). Analysis of SRIF has mainly been carried out by means of radioimmunoassay methods. Here, we propose the use of an electrochemical method, such as voltammetry, applied with carbon-based sensors and, in particular, the combination of differential pulse voltammetry with treated carbon fiber micro electrodes (DPV-µCFE) to facilitate the analysis of such peptidergic electro active hormones in the rat striatum and gastric tissue; the effect of growth hormone (GH) and epidermal growth factor (EGF), in particular, upon the SRIF signal has been studied in such tissues.
Finite element analysis of the effects of a floating mass transducer on the performance of a middle ear implant

Experimental evidence has shown that floating mass transducers (FMTs) play a key role in the performance of middle ear implants. However, because of the tiny size and complex structure of the middle ear, systematic experimental study of the influences of FMTs is difficult to carry out. In this paper we develop a FMT-attached middle-ear finite element model to investigate some effects of a FMT on the performance of a middle ear implant. This model was constructed based on a complete set of computerized tomography section images of a healthy volunteer's left ear. The validity of the developed model was verified by comparing the model-predicted motion of the tympanic membrane and stapes footplate with published experimental data. The result shows that the FMT produces a mass loading effect prominently at high frequencies, the force required to drive the incus to the equivalent of 100 dB sound pressure level (SPL) is about 89 μN, and setting the attachment position of the FMT close to the incudostapedial joint can enhance the driving effect.
Progressing to the Center: The Antecedents and Consequences of Lateral Authority

Post-bureaucratic forms of organizing are theorized to rely upon lateral as opposed to vertical authority, but few have studied how lateral authority operates in practice. With a longitudinal, multi-network study of a mature open source project, we predict what leads individuals to gain lateral authority over collective work. While technical contributions are initially important, coordination work become more critical at a subsequent stage. After gaining authority, individuals significantly increase the effort spent coordinating project work. By specifying the antecedents and consequences of lateral authority, our research refines our theoretical conception of how knowledge work in project and communities is coordinated.