Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence of treated cardiac arrest in hospitalized patients in the United States*

Objective:The incidence and incidence over time of cardiac arrest in hospitalized patients is unknown. We sought to estimate the event rate and temporal trends of adult inhospital cardiac arrest treated with a resuscitation response. Design:Three approaches were used to estimate the inhospital cardiac arrest event rate. First approach: calculate the inhospital cardiac arrest event rate at hospitals (n = 433) in the Get With The Guidelines-Resuscitation registry, years 2003–2007, and multiply this by U.S. annual bed days. Second approach: use the Get With The Guidelines-Resuscitation inhospital cardiac arrest event rate to develop a regression model (including hospital demographic, geographic, and organizational factors), and use the model coefficients to calculate predicted event rates for acute care hospitals (n = 5445) responding to the American Hospital Association survey. Third approach: classify acute care hospitals into groups based on academic, urban, and bed size characteristics, and determine the average event rate for Get With The Guidelines-Resuscitation hospitals in each group, and use weighted averages to calculate the national inhospital cardiac arrest rate. Annual event rates were calculated to estimate temporal trends. Setting:Get With The Guidelines-Resuscitation registry. Patients:Adult inhospital cardiac arrest with a resuscitation response. Measurements and Main Results:The mean adult treated inhospital cardiac arrest event rate at Get With The Guidelines-Resuscitation hospitals was 0.92/1000 bed days (interquartile range 0.58 to 1.2/1000). In hospitals (n = 150) contributing data for all years of the study period, the event rate increased from 2003 to 2007. With 2.09 million annual U.S. bed days, we estimated 192,000 inhospital cardiac arrests throughout the United States annually. Based on the regression model, extrapolating Get With The Guidelines-Resuscitation hospitals to hospitals participating in the American Hospital Association survey projected 211,000 annual inhospital cardiac arrests. Using weighted averages projected 209,000 annual U.S. inhospital cardiac arrests. Conclusions:There are approximately 200,000 treated cardiac arrests among U.S. hospitalized patients annually, and this rate may be increasing. This is important for understanding the burden of inhospital cardiac arrest and developing strategies to improve care for hospitalized patients.
Higher education is not associated with greater cortical thickness in brain areas related to literacy or intelligence in normal aging or mild cognitive impairment

Education may reduce risk of dementia through passive reserve, by increasing neural substrate. We tested the hypotheses that education is associated with thicker cortex and reduced rates of atrophy in brain regions related to literacy and intellectual ability. Healthy older adults and those with mild cognitive impairment were categorized into high (≥18 years) and low (≤13 years) education groups. Higher education was associated with thinner cortices in several areas, but one-year atrophy rates in these areas did not differ by education group. These results do not support a passive reserve model in which early-life education protects against dementia by increasing cortical thickness. Connectivity and synaptic efficiency or other lifestyle factors may more directly reflect cognitive reserve.
Time Synchronization Based on Spanning Tree for Wireless Sensor Networks

In recent years, wireless sensor networks have been an interesting and important research area. The time synchronization is an important problem for wireless sensor networks. In this paper, a novel time synchronization scheme based on spanning tree for wireless sensor networks is proposed. First, we create a spanning tree of all the nodes in the network by broadcasting children-find packets. Then, the spanning tree is divided into multiple subtrees, in which one subtree synchronization algorithm can be performed. After that, time synchronization of the whole network will be achieved. Performance analyses and simulations are presented in this paper, and demonstrate that our proposed scheme has much less synchronization error than RBS.
Identifying Human Disease Genes through Cross-Species Gene Mapping of Evolutionary Conserved Processes

Background Understanding complex networks that modulate development in humans is hampered by genetic and phenotypic heterogeneity within and between populations. Here we present a method that exploits natural variation in highly diverse mouse genetic reference panels in which genetic and environmental factors can be tightly controlled. The aim of our study is to test a cross-species genetic mapping strategy, which compares data of gene mapping in human patients with functional data obtained by QTL mapping in recombinant inbred mouse strains in order to prioritize human disease candidate genes. Methodology We exploit evolutionary conservation of developmental phenotypes to discover gene variants that influence brain development in humans. We studied corpus callosum volume in a recombinant inbred mouse panel (C57BL/6J×DBA/2J, BXD strains) using high-field strength MRI technology. We aligned mouse mapping results for this neuro-anatomical phenotype with genetic data from patients with abnormal corpus callosum (ACC) development. Principal Findings From the 61 syndromes which involve an ACC, 51 human candidate genes have been identified. Through interval mapping, we identified a single significant QTL on mouse chromosome 7 for corpus callosum volume with a QTL peak located between 25.5 and 26.7 Mb. Comparing the genes in this mouse QTL region with those associated with human syndromes (involving ACC) and those covered by copy number variations (CNV) yielded a single overlap, namely HNRPU in humans and Hnrpul1 in mice. Further analysis of corpus callosum volume in BXD strains revealed that the corpus callosum was significantly larger in BXD mice with a B genotype at the Hnrpul1 locus than in BXD mice with a D genotype at Hnrpul1 (F = 22.48, p<9.87*10−5). Conclusion This approach that exploits highly diverse mouse strains provides an efficient and effective translational bridge to study the etiology of human developmental disorders, such as autism and schizophrenia.
Tidal Streams as Probes of the Galactic Potential

We explore the use of tidal streams from Galactic satellites for recovering the potential of the Milky Way. Our study is motivated both by the discovery of the first lengthy stellar stream in the halo (Irwin & Totten) and by the prospect of measuring proper motions of stars brighter than 20th magnitude in such a stream with an accuracy of ~4 μas yr-1, as will be possible with the Space Interferometry Mission (SIM). We assume that the heliocentric radial velocities of these stars can be determined from supporting ground-based spectroscopic surveys and that the mass and phase-space coordinates of the Galactic satellite with which they are associated will also be known to SIM accuracy. Using the results from numerical simulations as trial data sets, we find that, if we assume the correct form for the Galactic potential, we can predict the distances to the stars as a consequence of the narrow distribution of energy expected along the streams. We develop an algorithm to evaluate the accuracy of any adopted potential by requiring that the satellite and stars recombine within a Galactic lifetime when their current phase-space coordinates are integrated backward. When applied to a four-dimensional grid of triaxial logarithmic potentials, with varying circular velocities, axis ratios, and orientation of the major axis in the disk plane, the algorithm can recover the parameters used for the Milky Way in a simulated data set to within a few percent using only 100 stars in a tidal stream.
Maintenance of transmitter release from neuromuscular junctions with different patterns of usage ‘ in vivo ’

The basic mechanisms underlying chemically-mediated neurotransmission at synapses are well established. Synaptic vesicles release their contents of neurotransmitter by exocytosis, and are then recycled and refilled before re-priming for re-release. It is less clear, however, what determines the differences in the quantitative aspects of this process at synapses with different in vivo activity patterns, and the extent to which they can be adapted to changing patterns of usage. The neuromuscular junction is particularly suited to investigations of these issues, due to the presence of distinctive muscle fibre types, with welldifferentiated physiological roles and hence, activity patterns. The relative accessibility of NMJs means that chronic recording and manipulation of in vivo activity patterns of single motor neurones are possible. Several laboratories around the world now examining how transmitter release at NMJs is adapted to maintain (or not) release under these identified activity patterns. This review will cover the current state of knowledge and briefly highlight areas where more research is required. For example, current knowledge is largely derived from invertebrate preparations, indicating a need for more detailed comparisons at mammalian NMJs with different activity patterns. Finally, it is not yet clear in any species whether adaptations observed with imposed activity can be driven to complete transformation, with appropriate stimulus regimes.
Traitor traceable signature scheme

A new signature scheme, traitor traceable signature scheme is presented, which allows the signer to convince any arbiter of the recipient's infringement, if the recipient distributes illegally the signature which he got. We use the techniques of a proof of knowledge of discrete logarithm, identification of double spender in an off-line electronic cash, and a signcryption scheme. Our scheme consists of a 3-move and it is more compact and efficient compared with the previous scheme, due to the elimination of the cumbersome cut-and-choose like techniques. Moreover, our accusation protocol does not require the private-key of the recipient of the signature, i.e., the signer can convince any arbiter of the recipient's infringement without the help of the original recipient.
On-Line Algorithms for Robot Navigation and Server Problems

Many classical problems of computer science such as paging, scheduling, and maintaining dynamic data structures are naturally on-line; an algorithm for such a problem is constantly making irrevocable decisions without knowing what its future input will be. The competitive analysis of on-line algorithms was brought into prominence by the work of Sleator and Tarjan in 1985 as a theoretical framework in which to measure the performance of such algorithms. Since then, a variety of on-line problems have been studied from this perspective. We consider two such problems in this setting: robot navigation, and computationally efficient algorithms for the k-server problem of Manasse, McGeoch, and Sleator. For the first of these, we give algorithms for a robot searching for a goal in an unknown simple polygon; our approach can be viewed as an extension of some of the strategies of Baeza-Yates, Culberson, and Rawlins to a more general class of geometric search spaces. We also provide the first competitive analysis of the robot localization problem a fundamental task for an autonomous mobile robot, in which it must determine its location in a known environment. Finally, we address the general question of how the performance of an on-line algorithm varies with the computational resources it has at its disposal. Within the context of the k-server problem, a natural specialization of this question is the following: can an algorithm which uses only constant space, and constant time in processing each request, match the performance of algorithms which are allowed to perform an arbitrary amount of computation at each step? We show a non-trivial lower bound for the class of 2-server balancing algorithms, a subclass of the constant-time algorithms; this represents one of the first lower bounds for an on-line algorithm based solely on its computational resources. Thesis Supervisor: Michel X. Goemans Title: Assistant Professor of Applied Mathematics
MGMT methylation correlates with melphalan pelvic perfusion survival in stage III melanoma patients: a pilot study

Approximately 25% of melanoma patients with locoregional metastases are nonresponsive to new molecular target therapy and immunotherapy. When metastases are located in the pelvis, melphalan hypoxic perfusion can be an optional treatment. Because methylation of MGMT promoter increases the efficacy of alkylating agents, studies on melanoma outcome of patients treated with melphalan regional chemotherapy should consider this epigenetic change. This study aims to evaluate whether the survival of stage III melanoma patients treated with melphalan regional chemotherapy may be correlated with MGMT methylation status. The metastatic tissues of 27 stage III melanoma patients with locoregional metastases located in the pelvis subjected to melphalan hypoxic pelvic perfusion were examined. The methylation status of the MGMT promoter was investigated by MS-MLPA probes analysis and the presence of the BRAF V600E mutation was analyzed by CAST-PCR. The median survival times were estimated using the Kaplan–Meier curves and were stratified according to the clinicopathological characteristics of patients and lesions. The overall median survival time was 17 months. The 1-year, 3-year, and 5-year survival rates were 66.7, 18.5, and 7.4%, respectively. Disease stage, burden, and percentage of MGMT methylation significantly affected survival. We estimated an MGMT promoter methylation cut-off of at least 14%, which was significantly associated with a longer survival after melphalan regional chemotherapy. Our data suggest that MGMT promoter methylation could be an important factor in determining which melanoma patients should receive melphalan regional chemotherapy, but its prognostic significance in the routine clinical setting needs to be clarified in a larger study.
Objectively Measured Sedentary Time Is Related to Quality of Life among Cancer Survivors

Purpose While exercise has been shown to be beneficial in improving health-related quality of life (HRQOL) among cancer survivors, evidence is limited on the independent role of sedentary behavior. We examined how objectively measured sedentary time was associated with HRQOL among long-term cancer survivors. Methods This cross-sectional study included 54 cancer survivors, on average 3.4 years postdiagnosis, who were enrolled into an exercise trial designed to improve cognitive function. At baseline, we measured sedentary time and moderate-vigorous intensity physical activity with the ActivPal, cardiorespiratory fitness with treadmill testing, and self-reported HRQOL with an established scale (SF-36). In multivariate models, we regressed HRQOL on sedentary time (percent of waking time spent sitting and lying). Results Survivors with higher sedentary time had significantly poorer physical functioning (β = −0.50, p = 0.028), general health (β = −0.75, ptrend = 0.004), and physical summary scores (β = −0.34, p = 0.003). We did not observe associations between sedentary time and role-physical (p = 0.342), bodily-pain (p = 0.117), vitality (p = 0.095), social functioning (p = 0.407), role-emotional (p = 0.509), mental health (p = 0.494), or mental summary scores (p = 0.527). Conclusion In this cross-sectional study of cancer survivors, we observed deleterious associations between sedentary time and aspects of physical HRQOL. Future prospective studies of sedentary time and HRQOL are needed to establish temporality and to facilitate the design of effective health promotion interventions for cancer survivors.
Measuring 3-D Surface Motion With Future SAR Systems Based on Reflector Antennae

A conventional interferometric synthetic aperture radar (SAR) system provides 1-D line-of-sight motion measurements from repeat-pass observations. Two-dimensional motions may be measured by combining two observations from ascending and descending geometries. The third motion component may be retrieved by adding a third geometry and/or by integrating along-track measurements although with much reduced precision compared to the other two components. Several options exist to improve the accuracy of retrieving the third motion component, such as combining left- and right-looking observations or exploiting recently proposed innovative SAR acquisition modes (BiDiSAR and SuperSAR). These options are, however, challenging for future SAR systems based on large reflector antennae, due to lack of capability to electronic beam steering or frequent toggle between left- and right-looking modes. Therefore, in this letter, we assess and compare the realistic acquisition scenarios for a reflector-based SAR in an attempt to optimize the achievable 3-D precision. Investigating the squinted SAR geometry as one of the feasible scenarios, we show that a squint of 13.5° will yield comparable performance to the left-looking acquisition, while further squinting outperforms this or other feasible configurations. As an optimum configuration for 3-D retrieval, the squinted acquisition is further elaborated: the different acquisition plans considering a constellation of two satellites as well as the challenges for data processing are addressed.
Racial Disparities in Health Service Utilization Among Medicare Fee-for-Service Beneficiaries Adjusting for Multiple Chronic Conditions

Objective: To examine racial disparities in health services utilization in Hawaii among Medicare fee-for-service beneficiaries aged 65 years and above. Method: All-cause utilization of inpatient, outpatient, emergency, home health agency, and skilled nursing facility admissions were investigated using 2012 Medicare data. For each type of service, multivariable logistic regression model was used to investigate racial disparities adjusting for sociodemographic factors and multiple chronic conditions. Results: Of the 84,212 beneficiaries, 27.8% were White, 27.4% were Asian, 27.3% were Pacific Islanders; 70.3% had two or more chronic conditions and 10.5% had six or more. Compared with Whites, all racial groups experienced underutilization across all types of services. As the number of chronic conditions increased, the utilization of inpatient, home health care, and skilled nursing facility dramatically increased. Discussion: Disparities persist among Asians and Pacific Islanders who encounter the problem of underutilization of various health services compared with Whites.
An improved medium for the anaerobic growth of Paracoccus denitrificans Pd1222

Paracoccus denitrificans is a well studied model organism with respect to its aerobic and anaerobic respiratory enzymes. However, until now, the growth medium for this organism has not been optimized for anaerobic growth. In particular, the requirements of P. denitrificans for trace elements (TEs) are not well known. In the present study we aimed to improve growth rates of P. denitrificans Pd1222 on a defined medium under anoxic conditions. We designed media containing different combinations of TEs at various concentrations, and tested their performance against previously reported media. Our results suggest that growth rate and yield depend on the availability and concentration of TEs in the medium. A chelated TE solution was more suitable than an acidified TE solution. Highest growth rates were achieved with medium comprising the TEs iron, manganese, molybdenum, copper and zinc ranging from 0.1 to 9 μM. On this medium, P. denitrificans Pd1222 grew with a generation time of 4.4 h under anoxic conditions and 2.8 h under oxic conditions. Diauxic growth was clearly shown with respect to nitrate and nitrite reduction under anoxic conditions.
Microscopic Characteristics of Lower Eyelid Retractors in Koreans

Purpose To identify the microscopic characteristics of lower eyelid retractors in Korean individuals and to elucidate age-related changes in lower eyelid retractors. Methods Eighteen Korean lower eyelids from formalin-fixed cadavers were stained with Masson's trichrome. Specimens were divided into two groups based on age at death (group A, ≤65 years; group B, >65 years), and the microscopic findings were analyzed and compared by light microscopy. Results The capsulopalpebral fascia (CPF) had distinct junctions and no fusion with orbital septum in 14 eyelids (77.8%). The CPF was fused with the orbital septum in only two eyelids (11.1%). Although not significant, the inferior tarsal muscle was closer to the tarsus in group A (1.24 ± 0.71 mm) than group B (2.14 ± 1.18 mm, p = 0.07), and the tarsal height tended to be longer in group B (4.71 ± 0.55 mm) than group A (4.16 ± 1.01 mm, p = 0.20). Tarsal fatty infiltration was more evident in group B. Conclusions The CPF was rarely fused with the orbital septum in our sample of Korean lower eyelids. Although we did not identify any remarkable age-related changes in lower eyelid structures, there was a tendency for the lower retractor to loosen from the tarsus and for increased fatty infiltration in the lower eyelids from elderly individuals.
In vitro genotoxic and cytotoxic effects of some paraben esters on human peripheral lymphocytes

Abstract Parabens (PBs) are p-hydroxybenzoic acid ester compounds commonly employed as antimicrobial preservatives, mainly in food, cosmetic, and pharmaceutical products. The aim of the present study was to investigate the genotoxic and cytotoxic effects of some paraben esters (butyl paraben, propyl paraben, isobutyl paraben, and isopropyl paraben) on human peripheral lymphocytes, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and cytokinesis-block micronucleus (CBMN) tests. Lymphocyte cultures were treated with four concentrations of PBs (100, 50, 25 and 10 µg/mL) for 24 and 48 h. Paraben esters significantly induced MN formations as compared to solvent control. Furthermore, butyl paraben and propyl paraben increased MN formations a concentration-dependent manner at 24 and 48 h. PBs increased the CA at 24 and 48 h. However, this increase was not meaningful for butyl paraben and isopropyl paraben at 48 h when compared with solvent control. Butyl, isobutyl, and isopropyl paraben significantly increased the SCE at 24 and 48 h. However, propyl paraben did not induce SCE meaningfully in both treatment periods. A significant decrease in the cytokinesis-block proliferation index and mitotic index was observed in cells exposed to all concentrations of PBs at 24 and 48 h. However, proliferation index was not affected at all concentrations of PBs after 24 h treatment, although it was decreased at the highest concentration of PBs at 48 h. It is concluded that all of the paraben esters used in this study have highly genotoxic and cytotoxic effects on human lymphocytes cells in vitro.