Miracle-dz/UniFAR-FTUs huggingface dataset:
E‐services and offline fulfilment: how e‐loyalty is created

Purpose – Most transactions initiated online are completed by some form of offline fulfilment, i.e. the delivery of the goods to the customer's doorstep. In previous studies, web site performance or e‐service quality was found to be an important antecedent of customer satisfaction and loyalty. In traditional settings, physical fulfilment is considered an important driver of customers’ behavioral intentions. This study models and tests the combined effects of online and offline service components on customer responses.Design/methodology/approach – This is an empirical, cross‐sectional study across four online industries.Findings – In the surveyed industries offline fulfilment appears to be at least as important as web site performance.Research limitations/implications – Further research is needed on how value and joy are created as part of the total e‐experience. Furthermore, the importance of offline fulfilment in effecting customer satisfaction and loyalty levels for different online services needs furth.
Pulmonary Hemorrhage Syndrome Associated with an Autochthonous Case of Dengue Hemorrhagic Fever

Dengue fever is a major public health problem worldwide. Dengue hemorrhagic fever, a much rarer form of the disease, occurs when a person previously infected with dengue is re-infected with a different viral serotype. In recent years the infection rates of dengue and both clinical syndromes have increased along the United States-Mexico border. We present the case of a 61-year-old Laotian female who presented with a 1-week history of fever, altered mental status, oral ulceration, and rash. The patient developed diffuse pulmonary hemorrhage and anemia requiring multiple transfusions. She eventually sustained multi-organ system failure and expired. Both the titer data and serologies were consistent with the diagnosis of dengue hemorrhagic fever. We hypothesize that this syndrome was the result of re-infection occurring within the United States. This case is also unusual in that it is the second reported in the literature of pulmonary hemorrhages associated with dengue hemorrhagic fever.
Epithelial Cell-Specific Laminin 5 Is Required for Survival of Early Thymocytes1

The gene LamC2 encoding the γ2 chain of laminin 5, an epithelial cell-specific extracellular matrix protein, was identified in a PCR-based subtracted cDNA library from mouse thymic stromal cells. The mRNA existed in two alternative forms (5.1 and 2.4 kb). The full-length message was highly expressed in SCID thymus and in a nurse cell line, but not in other thymic epithelial cell lines, while the short form was more widely expressed. In situ hybridization and immunohistochemical staining revealed laminin 5 expression mostly in the subcapsular region of the adult thymus. Addition to fetal thymic organ cultures of a cell adhesion-blocking mAb to the α3 chain of laminin 5 interrupted T cell development. There was a 40% reduction in the total yield of thymocytes, and the most profound decrease (75–90%) was seen in the CD25+CD44+ and CD25+CD44−subsets of the CD4−CD8− double negative fraction. Most of the surviving double negative thymocytes expressed Sca-1, and there were significant increases in the number of cells with CD69 expression and in the fraction of annexin V-stained cells. None of these changes were observed with a nonblocking anti-laminin α3 chain mAb. These results suggest that the interaction between double negative thymoctyes and laminin 5 made by subcapsular epithelial cells is required for the survival and differentiation of mouse thymocytes.
Similarity-based Multi-Lingual Multi-Document Summarization

We present a new multi-document system for summarizing automatic translations of foreign-language documents supplemented with related English documents and an evaluation of the system over data from the 2004 DUC conference. The system uses text similarity to choose sentences from the relevant English documents. Applying syntactic sentence simplification is shown to improve performance, and the approach outperforms first-sentence extraction baselines.
An intact histone 3'-processing site is required for transcription termination in a mouse histone H2a gene

A transcription termination site has been characterized between the mouse histone H2a-614 and H3-614 genes. There is a poly(A)- RNA present in small amounts in the nucleus which ends 600 nucleotides 3' to the H2a-614 gene. Nuclear transcription studies demonstrate that transcription extends at least 600 nucleotides 3' to the gene but is greatly reduced 700 nucleotides 3' to the gene. If all or part of the normal 3'-processing signal, consisting of the stem-loop and the U7 small nuclear ribonucleoprotein binding site, is deleted, transcription then continues past the putative termination site and RNAs which end at the 3' end of the downstream H3-614 gene accumulate. Insertion of a 150-nucleotide fragment containing the termination site between the histone 3' end and downstream polyadenylation sites reduces usage of polyadenylation sites 85 to 90%. Taken together these results suggest there is a transcription termination site which requires an intact histone 3'-processing signal to function.
Fast characterization of electrical fails overlaying to inline defect inspection during 90 nm copper logic technology development

The killer defect re-review method enables a fast identification of front end of line (FEOL) failure modes which is one of the keys to shorten yield learning cycles. This paper describes a combination of overlay techniques of electrical and defect inspection data on one hand and semi-automated defect review of electrically failing structures on the other hand. It was used during the 90 nm copper logic technology development in a joint project of Infineon Technologies Dresden and PDF Solutions and reduced physical failure analysis needs. A comparison of the overall defect density learning rates (including FEOL and copper back end of line limited yields) during 90 nm using this method and 130 nm copper logic technology development is given.
The aftermath of the Foot and Mouth crisis in agricultural logistics: the case of the UK fat lamb supply chain

Foot and Mouth disease (FMD) in the UK in 2001 exposed the complex nature of the structure in the domestic fat lamb supply chain. This supply chain comprises a large number of physical and information transactions between members and the underlying complexity is exacerbated by the limited use of traceability mechanisms. This paper provides a detailed overview of the structure and relationships in the UK fat lamb supply chain pre and post FMD 2001. The fat lamb transportation methods used by supply chain members based in the north-east of England are analysed to determine the members' opinions about optimum transportation practices in relation to cost efficiency, management of animal welfare and consumer safety. These three variables are also used to determine the supply chain members' opinions concerning the optimum location of auctions and abattoirs. The findings reveal, inter alia, the supply chain's changing structure and relationship dynamics during and post FMD 2001 and the need for improved integration between farmers, live auctions and abattoirs. 1Paper based on a research project funded by the Institute of Logistics and Transport (UK).
Stream Of Consciousness Technique and Modern Novel: Psychological and Methodological Perspectives on Language Learning

The main thesis of this commentary relates to the great influence of Literature, both fiction and literary criticism, and especially the stream of consciousness phenomenon in learning a foreign language. In desire to express the huge influences of literature, the stream of consciousness technique and human mental activities on learning foreign language, the author of this review tries partly to explain the basic thesis as the individual component of the complex and unbreakable connection among these three categories (literature, applied linguistics and psychology) covered by the mantle of cultural codex. The book entitled Globalization and management in foreign language learning process: English at the beginning of the third millennium by Dr. Slobodanka Djolic brings together a combination of divergent theoretical and practical approaches to the foreign language learning process and to the complex psychological phenomenon- stream of consciousness- in an era in which this phenomenon has become a landmark of literary theory. Really, the book is an methodological innovation which expresses the process of learning foreign languages as the equivalent of stream of consciousness writing technique through the prism of psychoanalytical approach to the spontaneous assimilation of different issues surrounding this phenomenon, appearing in the human psych as the part of conscious consciousness, unconscious consciousness or sub-consciousness. All these parameters participate in the learning process but mainly we cannot define them consciously. I. Psychoanalytical And Literary Approaches To The Stream Of Consciousness Phenomenon
The Circular Economy: Barriers and Opportunities for SMEs

The ‘circular economy’ is gaining momentum as a concept in both academic and policy circles, and circular business models have been linked to significant economic benefits. This paper identifies barriers and enablers to adopting circular economy business practices, and presents key messages for policy-makers. It draws on input from a literature review, on discussions held in the context of the GreenEcoNet project and on an analysis of two SME circular business models.
Spending on the Fly: Mental Budgets, Promotions, and Spending Behavior:

Abstract Recent research has suggested that consumers have in-store slack for grocery trips—that is, they leave room in their mental budgets to make unplanned purchases. Drawing on this work, this article examines how the impact of promotions depends on whether the shopper still has in-store slack remaining in his or her mental budget. Specifically, the authors evaluate how the effect of promotional savings for both planned and unplanned items on spending varies as a function of whether the item is purchased before or after the shopper's in-store slack is depleted. In addition, they examine how these relationships vary depending on income. To achieve these goals, the authors conducted a field study in which respondents used a handheld scanner to record the order of purchases. The results suggest that savings on planned items lead to stockpiling by higher-income shoppers when the savings occur before the in-store slack has been depleted but lead to increased purchase of unplanned items when they occur afte.
The virtual corporation: learning from construction

Manufacturing organisations are evolving towards virtual corporations, under the influence of an increasing need for specialisation. In the literature and in management the virtual corporation is advocated as the way of doing business for the twenty‐first century. However, in the construction industry, co‐operation in networks has long since been common practice. At the same time, the construction industry is known for its poor controllability. The manufacturing industry should, therefore, learn from the construction industry in order to avoid such problems. A typology for co‐operation and co‐ordination in construction is presented in this paper. Each of the types is evaluated for its strengths and weaknesses and conclusions are drawn regarding their applicability in manufacturing.
Effect of technology scaling on leakage power consumption in on-chip switches

On-chip switches in reconfigurable computing systems are prone to heavy drawing of current even when they are switched off. In this work, we have evaluated the effect of shrinking dimension of electronic devices on the basis of two fundamental factors: temperature and number of inputs to the multiplexer unit which is one of the basic building blocks of on-chip switching elements. In a particular technology node, rising temperature results in at least three folds increment in power consumption whereas the leakage power consumption shows exponential trend with increasing number of inputs.
Lack of association between using aspirin and development of non-Hodgkins lymphoma: a meta-analysis.

BACKGROUND Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. Epidemiological evidence suggests that aspirin may reduce the incidence and mortality of several cancers. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis. MATERIALS AND METHODS A total of 7 studies were included. Outcome was calculated and reported as odds ratios (ORs). Heterogeneity was assessed with Cochrane Q and I2 statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis. RESULTS Our analysis showed OR of developing NHL overall of 1(95% CI: 0.87-1.16, p=0.9), and in females this was 0.81 (95%CI: 0.72-.92, p=0.001) and in males 1.01 (95%CI: 0.82-1.26, p=0.86). The odds ratio (OR) of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 0.85 (95%CI: 0.75-0.97, p=0.02), The ORs of follicular lymphoma (FL) and large B-cell lymphoma (DLBCL) in individuals exposed to aspirin were 1.12 (95%CI: 0.86-1.45, p=0.37) and 1.03 (95%CI: 0.9-1.19, p=0.6) respectively. CONCLUSIONS In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma.
Dimensionality of sexual isolation during reinforcement and ecological speciation in Timema cristinae stick insects

Background: Speciation can involve variation in the dimensionality of population divergence (defined as variation in the number of independent ecological variables, phenotypic traits, or genes differing between populations). Recent work indicates that reproductive isolation between populations is multidimensional, but that this multidimensionality has an upper limit. A remaining question is how ecological and geographic factors affect the dimensionality of reproductive isolation. We address this question here, focusing on sexual isolation. Methods: The data used stem from previously published mating trials from 12 populations (comprising 66 pairwise population comparisons) of Timema cristinae stick insects that vary in host use and geographic arrangement (allopatry versus parapatry). We estimated the dimensionality of sexual isolation by calculating independent axes of divergence that represent combinations of (unmeasured) phenotypic traits and mating preferences that determine degree of sexual isolation. We then examined how populations varied along these axes. Results and conclusions: We found that despite the large number of population comparisons examined, only two dimensions were required to explain observed variation in sexual isolation. Furthermore, patterns of divergence illuminated ecological and geographic effects on the dimensionality of reproductive isolation. Males and females from allopatric populations were tightly clustered along one axis, consistent with sexual selection balanced by natural selection towards a single optimum. In contrast, parapatric males were widely dispersed across both axes, as would occur if reinforcement in parapatry were driving divergence in latent traits that remain constant in allopatry. Populations clustered to some extent by host plant use, although the effect was much weaker than that of geographic arrangement. We discuss our results in terms of the factors affecting speciation. In particular, if sexual isolation tends to have a strong upper limit to its dimensionality, as observed in our dataset, levels of divergence sufficient for speciation may require multiple forms of reproductive isolation.
Markets for data

Although datasets are abundant and assumed to be immensely valuable, they are not being shared or traded openly and transparently on a large scale. We investigate the nature of data trading with a conceptual market design approach and demonstrate the importance of provenance to overcome appropriability and quality concerns. We consider the requirements for efficient data exchange, comparing existing trading arrangements against efficient market models and show that it is possible to achieve either large markets with little control or small markets with greater control. We describe some future research directions.
Investment incentives for single and multiple unit franchisees

Purpose – This paper aims to provide a better understanding of the motivational incentives driving franchising choice from the franchisee's perspective and, in particular, to investigate a comparison of single and multiple unit franchisee incentives.Design/methodology/approach – A qualitative methodology was adopted to gain a clearer picture of the salient issues influencing an individual's evaluation of franchising options. Both single and multiple unit franchisees within the McDonald's restaurant chain were interviewed.Findings – Major contrasts were identified between single and multiple unit franchisees with regard to their motivations for entering franchising. In addition, franchisees who were previously employed were found to be different from those who were self‐employed.Research limitations/implications – Because it is difficult to identify potential multiple unit franchisees prior to joining a franchise, it was necessary to interview existing franchisees for this research. It is possible that the.
Cloning, sequence, and expression of a lipase gene from Pseudomonas cepacia: lipase production in heterologous hosts requires two Pseudomonas genes

The lipA gene encoding an extracellular lipase from Pseudomonas cepacia was cloned and sequenced. Downstream from the lipase gene an open reading frame was identified, and the corresponding gene was named limA. lipA was well expressed only in the presence of limA. limA exerts its effect both in cis and in trans and therefore produces a diffusible gene product, presumably a protein of 344 amino acids. Replacement of the lipA expression signals (promoter, ribosome-binding site, and signal peptide-coding sequences) by heterologous signals from gram-positive bacteria still resulted in limA-dependent lipA expression in Escherichia coli, Bacillus subtilis, and Streptomyces lividans.
Crystal structure of glutamine amidotransferase from Thermotoga maritima

Glutamine amidotransferases (GATases) are ubiquitous enzymes that transfer the amide nitrogen of glutamine to a variety of substrates.1 GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. Imidazole glycerol phosphate synthase (IGPS) is a GATase that catalyzes the bifurcation step of the histidine and de novo purine biosynthetic pathways. In yeast, IGPS is a single polypeptide,2 whereas in bacteria IGPS activity is effected by a complex of a glutaminase subunit, HisH, and a synthase subunit, HisF.3,4 IGPS is a class I GATase, which is characterized by a Cys–His–Glu catalytic triad. IGPS is a potential target for antibiotic and herbicide development because the histidine pathway does not occur in mammals. Here, we present the crystal structure of the HisH protein from Thermotoga maritima (TmHisH), which complements the known structure of HisF from the same organism (TmHisF)5 [Protein Data Bank (PDB) ID 1THF] and HisF from Pyrobaculum aerophilum6 (PDB ID 1H5Y) and shows high structural similarity with the glutaminase domain of the recently determined structure of IGSP from yeast7 (HIS7) (PDB ID 1JVN).
Suicide and undetermined death in south east Scotland. A case–control study using the psychological autopsy method

Background. Mental disorders are major risk factors for suicide. Not all those who suffer from mental disorders kill themselves. Additional information is required to differentiate higher and lesser risk patients. Methods. Retrospective case–control comparison was made of cases of suicide/undetermined death with living controls using psychological autopsy in South East Scotland. Cases and controls were matched for age, sex and mental disorder. Informants were those closest to cases and controls. The subjects were 45 cases of suicide/undetermined death and 40 living controls. Results. Cases and controls did not differ significantly in severity of mental disorder. The main factors independently associated with undetermined death or suicide were: a history of deliberate self-harm (adjusted OR 4·1); physical ill health (adjusted OR 7·8); and engagement by mental health services (adjusted OR 0·01). Other antecedents associated with increased risk (criminal record, police involvement, financial problems and failure to vote) and those associated with decreased risk (contact with a doctor and in-patient care) did not exert effects after controlling for confounding. Conclusions. Controls were receiving more care of whatever kind. Treatment of mental disorder co-morbid with physical illness and a history of deliberate self-harm may be especially important. Factors that separate those with mental disorder at high risk from those at lesser risk relate to care levels provided, which may be a function of engagement by and with health services. The role of mental health professionals is beneficial in suicide prevention. The focusing of that role towards engaging alienated or ‘difficult’ patients should be addressed.
A Pharmacometric Approach to Quantify the Impact of Chronic Kidney Disease and Hemodialysis on Systemic Drug Exposure: Application to Saxagliptin

The draft United States Food and Drug Administration guidance recommends a dedicated pharmacokinetic (PK) study for most drugs intended for use in patients with chronic kidney disease (CKD), including stage V patients requiring hemodialysis (HD) treatment. However, clinical studies conducted in CKD patients are challenged by difficulties in recruiting stage IV and V patients not yet on dialysis, and in balancing patient characteristics among each studied CKD group. Furthermore, study design for dialysis patients often involves a single dose administered before an HD session. The design may not necessarily represent usual patient care in current clinical practice, in which multiple doses are more likely to be administered at varying times between HD sessions. Using exposure modeling of saxagliptin and its active metabolite, 5‐hydroxy saxagliptin, as an example, this work illustrates how these challenges can be alleviated by modeling the impact of HD on drug exposure in clinical studies and simulating the expected exposure level in patient care. The modeled PK profiles in dialysis patients were used to understand PK profiles in patients with various CKD stages. The applied pharmacometric approach increased the efficiency of knowledge generation from existing data.
Fluorescence anisotropy studies on the Hoechst 33258-DNA interaction: the solvent effect

Abstract Fluorescence anisotropy method was applied to characterize the interactions of DNA minor groove binder Hoechst 33258 with different solvents without and in the presence of DNA. It is important to study the interaction of small molecules with DNA for the purpose of better understanding the mechanism of their action, as well as to design novel and more effective compounds. Spectroscopic study of the ligand in different binary mixed solvents containing DMSO, alcohols and buffer was carried out. Studies were performed without and in the presence of DNA. Fluorescence anisotropy studies reveal the characteristics of Hoechst 33258 in different mixed solvents. The results show the strong dependence of the anisotropy of Hoechst 33258 on solvent content, viscosity and intermolecular interactions. Communicated by Ramaswamy H. Sarma