Miracle-dz/UniFAR-FTUs huggingface dataset:
Competition and Public Service Broadcasting: Stimulating Creativity or servicing Capital?

In UK public service broadcasting, recent regulatory change has increased the role of the private sector in television production, culminating in the BBC's recent introduction of 'creative competition' between in-house and independent television producers. Using the concept of 'cognitive distance', this paper focuses on the increasing role of the independent sector as a source of creativity and innovation in the delivery of programming for the BBC. The paper shows that the intended benefits of introducing new competencies into public service broadcasting have been thwarted by, on the one hand, a high level of cognitive proximity between in-house and external producers and, on the other, a conflict in values between the BBC and the independent sector, with the latter responding to a commercial imperative that encourages creativity in profitable genres, leaving gaps in other areas of provision. While recent regulatory reform appears to have had a limited impact on the diversity of programming, it does suggest a closer alignment of programme content with the imperatives of capital. Implications for the literature on communities of practice are noted.
Metabolism of ethanol to acetaldehyde by rat uterine horn subcellular fractions

Controversial studies from others suggested that alcohol intake could be associated with some deleterious effects in the uterus. Not all the effects of alcohol drinking on female reproductive organs can be explained in terms of endocrine disturbances. Deleterious effect of alcohol or its metabolites in situ could also play a role. Accordingly, we found a metabolism of alcohol to acetaldehyde in the rat uterine horn tissue cytosolic fraction mediated by xanthine oxidoreductase, requiring a purine cosubstrate and inhibited by allopurinol. This activity was detected by histochemistry in the epithelium and aldehyde dehydrogenase activity was detected in the muscular layer and in the serosa. There was a microsomal process, not requiring NADPH and of enzymatic nature, oxygen-dependent and inhibited by diethyldithiocarbamate, diphenyleneiodonium and partially sensitive to esculetin and nordihydroguaiaretic acid. The presence of metabolic pathways in the uterine horn able to generate acetaldehyde, accompanied by a low capacity to destroy it through aldehyde dehydrogenase, led to acetaldehyde accumulation in the uterus during ethanol exposure. Results suggest that any acetaldehyde produced in situ or arriving to the uterine horn via blood would remain in this organ sufficiently to have the opportunity to react with critical molecules to cause deleterious effects.
Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

The mTORC1 signaling pathway is a critical regulator of cell growth and is hyper activated in many different cancers. Rapamycin, an allosteric inhibitor of mTORC1, has been approved for treatment against renal cell carcinomas and is being evaluated for other cancers. Mechanistically, mTORC1 controls cell growth in part through its two well-characterized substrates S6K1 and 4E-BP1. In this review, we discuss the implications of a recent finding that showed differential inhibition of S6K1 and 4E-BP1 by rapamycin, leading to cell-type-specific repression of cap-dependent translation. We discuss potential mechanisms for this effect, and propose that mTOR-specific kinase inhibitors, instead of rapamycin, should be considered for mTOR-targeted cancer therapy.
The spatial targeting and nuclear matrix binding domains of SRm160

The Ser-Arg (SR)-related protein SRm160 is a coactivator of pre-mRNA splicing. It bridges splicing factors located at the 5′ splice site, branch site, and 3′ splice site. Recently, SRm160 has also been shown to be involved in mRNA export as part of an exon-junction complex. SRm160 is highly concentrated in splicing speckles but is also present in long branched intranuclear tracks connecting splicing speckles with sites at the nuclear lamina. In this study we identified domains of SRm160 important for spatial targeting within the nucleus and for binding to the nuclear matrix. Using a series of FLAG- and enhanced GFP-conjugated deletion mutants we found two contiguous sequences that independently target SRm160 to nuclear matrix sites at splicing speckled domains: amino acids 300–350 and 351–688. Constructs containing amino acids 300–350 were also targeted to sites peripheral to speckled domains where most mRNA originate subsequent to splicing. Sequences from the N-terminal domain localized proteins to the nuclear lamina near sites where mRNA leaves the nucleus.
Stock Returns Indicators: Debt to Equity, Book to Market, Firm Size and Sales to Price

Financial variables are useful indicator for future stock returns. In the USA market during the period of 1963-90 the book to market value and firm size have more explanatory power for future stock returns. But some studies argue that sales to price ratio and debt to equity explain future stock returns better than the book to market value and firm size. The main objective of this study is to see which financial variable explains stock returns better than the others. In this study the four financial variables debt to equity, book to market value of equity, firm size and sale to price are used. The study includes 26 companies from pharmaceutical and chemical sector in Pakistan and listed on the Karachi Stock Exchange. The regression technique is used to see the relationship between stock returns and financial variables. We find that the best indicator for stock returns in Pakistani stock market is book to market value of equity for the studied period 2000-2009.
Are social media replacing traditional media in terms of brand equity creation

Purpose - The purpose of this paper is to investigate the relative impact of brand communication on brand equity through social media as compared to traditional media. In a juxtaposition of different industries it aims at: investigating whether both communication instruments have an impact on consumer-based brand equity; comparing the effect sizes of these two communication instruments; and separating the effects of firm-created and user-generated social media communication. Design/methodology/approach - A total of 393 data sets from three different industries, namely tourism, telecommunications, and pharmaceuticals, were generated using a standardized online-survey. Structural equation modeling was used in the analysis of the data obtained to investigate the interplay of social media and traditional media in general, as well as in an examination of industry-specific differences. Findings - The results of the empirical study show that both traditional communications and social media communications have a significant impact on brand equity. While traditional media has a stronger impact on brand awareness, social media communications strongly influence brand image. Firm-created social media communication is shown to have an important impact on functional brand image, while user-generated social media communication exerts a major influence on hedonic brand image. Furthermore, the present study highlights significant differences between the industries under investigation. Originality/value - The research described in this paper is pioneering in that it juxtaposes the impacts of social media and traditional media on brand equity – a topic of increasing interest to firms in the era of Facebook and Twitter but so far largely uninvestigated. Moreover, the differentiation between firm-created and user-generated social media communication, which is gaining increasingly in importance, as companies see their brand marketing power devolve to the consumer through social media platforms, offers valuable insights to marketing practitioners and academics.
Toward an understanding of the role of agency and choice in the changing structure of Canada's national sport organizations.

The period between 1984 and 1988 was one of considerable change in the Canadian sport system. National sport organizations (NSOs) were subject to institutional pressures from the government agency Sport Canada to dispense with their traditional operating procedures and move to a more professional bureaucratic organizational design. Researchers who have studied this time period have suggested that NSOs were passive receptors of these government pressures and that they acquiesced to the changes promoted by Sport Canada. This paper challenges this idea and suggests that the role of human agents and the choices they made in response to the pressures emanating from the state agency are important aspects of the change dynamic. Using data from a study of 36 NSOs, this paper shows that NSOs demonstrated resistance in the form of pacifying activities and ceremonial conformity.
SHOCK-ENHANCED C+ EMISSION AND THE DETECTION OF H2O FROM THE STEPHAN'S QUINTET GROUP-WIDE SHOCK USING HERSCHEL

We present the first Herschel spectroscopic detections of the [O i] 63 μm and [C ii] 158 μm fine-structure transitions, and a single para-H2O line from the 35 × 15 kpc2 shocked intergalactic filament in Stephan's Quintet. The filament is believed to have been formed when a high-speed intruder to the group collided with a clumpy intergroup gas. Observations with the PACS spectrometer provide evidence for broad (>1000 km s−1) luminous [C ii] line profiles, as well as fainter [O i] 63 μm emission. SPIRE FTS observations reveal water emission from the p-H2O (111–000) transition at several positions in the filament, but no other molecular lines. The H2O line is narrow and may be associated with denser intermediate-velocity gas experiencing the strongest shock-heating. The [C ii]/PAHtot and [C ii]/FIR ratios are too large to be explained by normal photo-electric heating in photodissociation regions. H ii region excitation or X-ray/cosmic-ray heating can also be ruled out. The observations lead to the conclusion that a large fraction the molecular gas is diffuse and warm. We propose that the [C ii], [O i], and warm H2 line emission is powered by a turbulent cascade in which kinetic energy from the galaxy collision with the intergalactic medium is dissipated to small scales and low velocities, via shocks and turbulent eddies. Low-velocity magnetic shocks can help explain both the [C ii]/[O i] ratio, and the relatively high [C ii]/H2 ratios observed. The discovery that [C ii] emission can be enhanced, in large-scale turbulent regions in collisional environments, has implications for the interpretation of [C ii] emission in high-z galaxies.
Language, knowledge transfer and firm’s strategic assets: the strategic role of language in knowledge transfer to China

This article is intended to examine the exact role of language in intra-firm cross-country knowledge transfer from the perspective of developing firm’s strategic assets. We find that inadequate language ability can lead to communication failures and cultural misunderstanding, and has the potential to destroy the process of knowledge transfer. Hence, language is not an operational issue but of strategic importance to the transfer of knowledge within multinational enterprises. As language ability is uniquely related to the specific technical, managerial and cultural aspects of a firm, hard to substitute and imitate, it should be regarded as one of the firm’s strategic assets and be dealt at strategic level.
pp60src -mediated Phosphorylation of Connexin 43, a Gap Junction Protein (*)

Several laboratories have demonstrated a decrease in gap junctional communication in cells transformed by the src oncogene of the Rous sarcoma virus. The decrease in gap junctional communication was associated with tyrosine phosphorylation of the gap junction protein, connexin 43 (Cx43). This study was initiated to determine if the phosphorylation of Cx43 is the result of a direct kinase-substrate interaction between the highly active tyrosine kinase, pp60vsrc, and Cx43. Previous biochemical studies have been limited by the low levels of Cx43 protein in fibroblast cell lines. To obtain larger quantities of Cx43, we constructed a recombinant baculovirus expressing Cx43 in Spodoptera frugiperda (Sf-9) cells and subsequently purified the expressed Cx43 by immunoaffinity chromatography. We observed that this partially purified Cx43 was phosphorylated on tyrosine in vitro in the presence of kinase-active pp60src. Phosphotryptic peptide mapping indicated that the in vitro phosphorylated Cx43 contained phosphopeptides which comigrated with a subset of tryptic peptides prepared from Cx43 phosphorylated in vivo. Furthermore, coinfection of Sf-9 cells with recombinant baculoviruses encoding pp60vsrc and Cx43 resulted in the accumulation of phosphotyrosine in Cx43. Taken together, the evidence presented in this paper demonstrates that kinase active pp60csrc is capable of phosphorylating Cx43 in a direct manner. Since the presence of phosphotyrosine on Cx43 is correlated with the down-regulation of gap-junctional communication, these results suggest that pp60vsrc regulates gap junctional gating activity via tyrosine phosphorylation of Cx43.
Algunos conceptos de la econometría espacial y el análisis exploratorio de datos espaciales

Resumen:El presente articulo es parte del trabajo realizado en el proyecto de Investigacion Analisis Exploratorio de Datos Espaciales y el Indice de Moran", el cual es financiado con fondos de la Universidad EAFIT para el ano 2008. En este trabajo se presenta una descripcion de los efectos espaciales que se pueden encontrar cuando se trabaja con datos georreferenciados, ademas se hace un desarrollo formal introductorio relacionado con el estadistico I de Moran, uno de los test mas utilizados para contrastar la autocorrelacion espacial. Se presenta tambien un caso de aplicacion en el cual se muestra la importancia del analisis exploratorio de datos espaciales (AEDE), en el proceso de analisis de fenomenos que esten enmarcados en un contexto regional. "
Anisakid Nematodes of Greenland Halibut Reinhardtius hippoglossoides from the Barents Sea

Abstract: Parasitic nematodes from the body cavity of 94 Greenland halibut (Reinhardtius hippoglossoides) caught in the Barents Sea were examined. Nematode species were identified using both morphological and molecular methods. Four morphospecies were found: Anisakis simplex s.l. , Contracaecum osculatum s.l. , Pseudoterranova decipiens s.l. , and Hysterothylacium aduncum. The most prevalent were C. osculatum s.l. (89.4%) and A. simplex s.l. (86.2%). Mean intensities for these 2 species were 7.8 and 45.2, respectively. The number of parasites was directly proportional to the fish length. The following 6 parasite species, including 3 cryptic species of Contracaecum sp. , were identified using molecular methods: A. simplex sensu stricto, C. osculatum A, C. osculatum B and C (the last 2 as host records for halibut), Pseudoterranova bulbosa, and H. aduncum. Mixed infections of C. osculatum A, B, and C were observed.
It May be Social, But Why is it Capital? The Social Construction of Social Capital and the Politics of Language

Although the referents of the term social capital merit sustained inquiry, the term impedes understanding because of the historical association of the word capital with economic discourse. As a result of this association, applying the term social capital to civic engagement blurs crucial analytic distinctions. Moreover, there are important ideological consequences to considering things such as bowling leagues to be a form of capital and urging citizens to become social capitalists. The term social capacity, the authors argue, provides the same heuristic benefits as the term social capital without extending illusory promises of theoretical parsimony with the financial/human/social capital trinity.
Selective tumor apoptosis by MF13, L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester, a new sarcolysin containing tripeptide.

ID50 and ID90 values for L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester HCl (MF13), were determined in four murine (leukemia, lymphoma, melanoma, and lung) and eight human cancer cell lines (two leukemia, prostate, kidney, colon, two melanoma, and breast). Cytotoxic activity was 2-5 times higher than that of sarcolysin [(L-3-[bis(2-chloroethyl)amino]-L-phenylalanine] against all leukemias and lymphomas, ID50 0.5-0.9 microM, and against human solid tumors, ID50 0.4-2.1 microM. Sensitivities of L-phenylalanine mustard-resistant and methotrexate-resistant L1210 cells were the same as the naive lines, ID50 0.5 microM. Apoptosis was confirmed by: (a) morphology, revealing chromatin condensation and nuclear fragmentation; (b) flow cytometry, showing changes in cell size and DNA integrity; and (c) DNA electrophoresis, demonstrating multiples of 180-200-bp DNA units. MF13 had no cytotoxicity against human peripheral blood lymphocytes at concentrations lethal to tumor cells (ID50, 13.3 microM without and 11 microM with phytohemagglutinin stimulation) and failed to induce apoptosis. s.c. MF13 treatment of mice with advanced EL4 leukemic ascites yielded extensive apoptosis, with DNA degradation identical to that seen in vitro, and resulted in complete tumor regression in all treated mice. These results suggest MF13 as a potential chemotherapeutic agent.
In the Endemic Setting, Clostridium difficile Ribotype 027 Is Virulent But Not Hypervirulent

BACKGROUND Conflicting reports have been published on the association between Clostridium difficile ribotypes and severe disease outcomes in patients with C. difficile infection (CDI); several so-called hypervirulent ribotypes have been described. We performed a multicenter study to assess severe disease presentation and severe outcomes among CDI patients infected with different ribotypes. METHODS Stool samples that tested positive for C. difficile toxin were collected and cultured from patients who presented to any of 7 different hospitals in Houston, Texas (2011–2013). C. difficile was characterized using a fluorescent PCR ribotyping method. Medical records were reviewed to determine clinical characteristics and ribotype association with severe CDI presentation (ie, leukocytosis and/or hypoalbuminemia) and severe CDI outcomes (ie, ICU admission, ileus, toxic megacolon, colectomy, and/or in-hospital death). RESULTS Our study included 715 patients aged 61±18 years (female: 63%; median Charlson comorbidity index: 2.5±2.4; hospital-onset CDI: 45%; severe CDI: 36.7%; severe CDI outcomes: 12.3%). The most common ribotypes were 027, 014-020, FP311, 002, 078-126, and 001. Ribotype 027 was a significant independent predictor of severe disease (adjusted odds ratio [aOR], 2.24; 95% confidence interval [CI], 1.53–3.29; P<.001) and severe CDI outcomes (aOR, 1.71; 95% CI, 1.02–2.85; P=.041) compared with all other ribotypes in aggregate. However, in an analysis using all common ribotypes as individual variables, ribotype 027 was not associated with severe CDI outcomes more often than other ribotypes. CONCLUSION Ribotype 027 showed virulence equal to that of other ribotypes identified in this endemic setting. Clinical severity markers of CDI may be more predictive of severe CDI outcomes than a particular ribotype. Infect. Control Hosp. Epidemiol. 2015;36(11):1318–1323
A paradigm shift in academic medicine?

The author states that one definition of “paradigm shift” is “the process whereby a governing conceptual framework becomes destabilized and is eventually replaced, more or less wholesale, by a new conceptual consensus. ” He asks whether recent fundamental changes in academic medicine amount to a paradigm shift, and then briefly describes and comments on 25 changes under way in academic medicine (e.g., the growing importance of cost considerations; focus on episodic care of the acutely ill individual moving instead toward clinical and fiscal responsibility for the health of a population; relative autonomy of the physician evolving to increasing interdependence, both clinical and financial). The author maintains that the basic conceptual framework of academic medicine's core mission--patient care, teaching, and research--remains the same, and that this mission's capacity for good has greatly grown in recent decades. Over the same interval the core business of academic medicine (i.e., its financing) and how that relates to the core mission have indeed become destabilized. These also comprise a “conceptual framework” by which academic medicine has functioned, and that framework is being replaced, compellingly, by what amounts to a new conceptual consensus--in short, a paradigm shift. He urges his colleagues in academic medicine to be clear-eyed, responsive, and innovative, and never to give up as they work to forge a new and sustainable system that maintains and strengthens scholarship and service.
Welfare: theoretical and analytical paradigms

The paper reviews paradigms of welfare, principally the industrialization thesis, the three worlds of welfare and social investment states and shows how these link to wider public policies and underlying assumptions. It locates explanations in historical and contemporary contexts. The literature of social policy is seen to be both descriptive and prescriptive and to have developed in response to key crises. The paper considers arguments for and against universalism and targeting, and shows how these concepts fit within theories of welfare. It considers lessons from this review for discussions of how to develop social security and health systems in emerging economies and indicates the value of systems that include all or the vast majority of the population, organized around principles of collective social insurance and recognize the value of caring work. Proposals have, however, to be set in economic systems with fair, living wages and progressive income tax structures—goals which run counter to the current trajectory of financial capitalism.
The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease

Cardiovascular disease (CVD) is the leading cause of death worldwide and its prevalence is expected to rise rapidly worldwide in the coming decades. Atherosclerosis, the syndrome underlying CVD, is a chronic progressive disease of the arteries already present at a young age. Strokes, heart attacks and heart failure are acute CVD events that occur after decades, however, and require timely diagnosis and treatment. Plasma extracellular vesicles (EVs) are microstructures with a lipid bilayer membrane involved in hemostasis, inflammation and injury. Both EV-counts and EV-content are associated with CVD and the identification of plasma EVs is a novel source of blood-based biomarkers with the potential to improve diagnosis and prognosis of CVD. Presented in this review is an overview of the current use of EVs in CVD and a discussion of the need for robust and easy isolation technologies for plasma EV subsets. This is needed to bring this promising field towards clinical application in the patient.