Miracle-dz/UniFAR-FTUs huggingface dataset:
A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

Several of the SNF and SWI genes of Saccharomyces cerevisiae code for proteins believed to assist transcriptional activators by relieving nucleosome repression. One of these proteins, SNF2/SWI2, has a homologue in Drosophila, a regulator of homeotic genes known as brahma or brm. In this report, we show that a counterpart of SNF2/SWI2 also exists in mice and humans. The human protein, designated hbrm, is a 180 kDa nuclear factor that can function as a transcriptional activator when fused to a heterologous DNA binding domain. The mouse homologue of hbrm is expressed in all mouse organs tested while hbrm was detected in some but not all investigated human cell lines. In cells failing to express the endogenous gene, transfected hbrm cooperates with the glucocorticoid receptor (GR) in transcriptional activation. However, hbrm had no effect on the activity of several other transcription factors, including the homeoprotein HNF‐1. The co‐operation between hbrm and GR required the DNA binding domain of GR and two separated regions of the hbrm protein, including a domain with homology to known helicases.
POLITICAL MINER: OPINION EXTRACTION FROM USER GENERATED POLITICAL REVIEWS

Phones:0333-9968518, 0345-8981401, 0322-9527806, 0333-9760222, 0321-9606033, 0302-2959588 ABSTRACT: Millions of users share their opinions on micro blogging websites through short messages on different topics. Opinion mining determines the mood, feelings, emotions or opinions of other people about services, politics, products and policies.In this paper we introduce a rule based opinion mining system that will evaluate the opinion of users they shared on twitter in response to some key political discourse. This framework will automatically crawl the tweets from twitter API, categorize text into subjective and objective tweets, calculates the polarity score at tweet and word level, and generate an aggregate of more than 500 political tweets. This approach shows impressive results and out performs the baseline method. The effectiveness of the proposed system is presented in a case study.
Modelling and analysis of quadruped walking robot using singular system theory

In this paper, the modelling and analysis problem of a planar quadruped walking robot with eight degrees of freedom using singular system theory is investigated. First, a brief description about singular system is given and then, the singular model of the quadruped robot is derived. Because of the complexity of the singular model of the robot, we linearized it around the contact point of the leg and the ground, and based on this model it is shown that impulses are generated in the force which exists between leg and ground in the contact points.
Primary and secondary infertility in sub-Saharan Africa.

BACKGROUND No previous study has provided national estimates of the prevalence of primary and secondary infertility in sizeable areas of sub-Saharan Africa. METHODS Primary infertility is measured by the proportion childless among women who entered their first marriage at least 7 years before date of censoring. Secondary infertility is measured by the 'subsequently infertile estimator' from parous ever-married women. Exposure begins at the age of the woman at the birth of her first child, and exposure ends when the woman is of an age, which is 5 years lower than her age at censoring. These last 5 years are used to determine her status as infertile or fertile at the last observation 5 years before censoring. A woman is considered infertile at last observation if she has had no livebirths during the last 5 years before censoring, otherwise she is considered fertile. A woman who has not given birth at age a or later is defined as being 'infertile subsequent to age a'. The index of the proportion subsequently infertile at age a is estimated as the number of women infertile subsequent to age a, divided by the total number of women observed at that age. Infertility is estimated for women age 20-44. RESULTS Primary infertility is relatively low and it exceeds 3% in less than a third of the 28 African countries analysed. In contrast, elevated levels of secondary infertility prevail in most countries. Secondary infertility for women age 20-44 ranges from 5% in Togo to 23% in Central African Republic. CONCLUSIONS It is feasible to gauge national levels of primary and secondary infertility from population based surveys including a birth history. The prevalence of infertility of pathological origin is so high in sub-Saharan Africa that infertility is not merely an individual concern, it is a public health problem.
Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels.

CHIP28 occurs naturally in glycosylated and nonglycosylated forms. The purpose of this study was to determine the role of glycosylation in CHIP28 structure and function. A new purification procedure based on phenylboronic acid-agarose (PBA) affinity chromatography was developed to isolate CHIP28. In purified native CHIP28 from erythrocytes, approximately 50% of CHIP28 molecules were glycosylated; each mole of glycosylated CHIP28 contained 5.4 kDa of monosaccharides consisting of 2 mol of Fuc, 8 mol of Gal, 1 mol of GalN, 13 mol of GlcN, 3 mol of Man, and 1 mol of Neu5Ac. The proportions of each monosaccharide and the sensitivity to endo-beta-galactosidase indicated that CHIP28 contained polylactosaminyl oligosaccharides. Glycosylated and nonglycosylated CHIP28 remained tightly associated when solubilized in octyl beta-D-glucoside (OG) and could not be separated by conventional chromatographic procedures. To remove the sugar moiety, CHIP28 was enzymatically deglycosylated by PNGase F and purified by Q-Sepharose anion-exchange and Erythrina cristagalli lectin chromatography. High-performance size-exclusion chromatography revealed that native CHIP28 eluted as an apparent dimer, whereas deglycosylated CHIP28 eluted as an apparent monomer. In reconstituted proteoliposomes, deglycosylated CHIP28 had a single channel water permeability (pf) of 3.1 x 10(-14) cm3/s (10 degrees C), not different from that of 3.2 x 10(-14) cm3/s for native CHIP28. Circular dichroism of native and deglycosylated CHIP28 in OG revealed 45% and 48% alpha-helix, respectively; intrinsic tryptophan fluorescence showed no effects of glycosylation on tryptophan environment. Freeze-fracture electron microscopy with rotary shadowing indicated that native and deglycosylated CHIP28 assembled as tetramers in reconstituted proteoliposomes. (ABSTRACT TRUNCATED AT 250 WORDS)
Legal Capital, Financial Information and Net Assets: A Reply to Francesco Denozza (Capitale Sociale, Informazione Contabile E Sistema Del Netto: Una Risposta a Francesco Denozza)

This article is a reply to an essay in defense of the legal capital doctrine published in 2002 by Francesco Denozza as a response to Enriques and Macey's article against the European legal capital rules. After showing that the legal capital doctrine is being eroded by reforms both at the EC and at the national level, the article criticizes Denozza's arguments in favor of legal capital: the presence of information asymmetries between creditors and their corporate debtors and of agency problems within the firm, the fact that there will be a suboptimal production of contractual devices protecting creditors as a class, and the idea that there should be some form of early warning system for companies on the brink of insolvency are not enough to justify legal capital rules, once their costs are taken into account. The paper concludes that the legal capital doctrine, if it is not to remain (or become) a mere vestige of itself, ie. if it imposes meaningful net assets requirements for the set-up and operations of companies, is a socially and economically conservative policy: it favors new ventures backed by wealthy families and/or incumbent companies, it raises barriers to entry in the product markets, and it makes it easier to finance industries requiring investments in real assets than those based mainly on human capital, ie. it favors the least dynamic sectors in today's economy.
Signal transduction and molecular targets of selected flavonoids.

SIGNIFICANCE Diet exerts a major influence on the risk for developing cancer and heart disease. Food factors such as flavonoids are alleged to protect cells from premature aging and disease by shielding DNA, proteins, and lipids from oxidative damage. RECENT ADVANCES Our work has focused on clarifying the effects of dietary components on cancer cell proliferation and tumor growth, discovering mechanisms to explain the effects, and identifying the specific molecular targets of these compounds. Our strategy for identifying specific molecular targets of phytochemicals involves the use of supercomputer technology combined with protein crystallography, molecular biology, and experimental laboratory verification. CRITICAL ISSUES One of the greatest challenges for scientists is to reduce the accumulation of distortion and half truths reported in the popular media regarding the health benefits of certain foods or food supplements. The use of these is not new, but interest has increased dramatically because of perceived health benefits that are presumably acquired without unpleasant side effects. Flavonoids are touted to exert many beneficial effects in vitro. However, whether they can produce these effects in vivo is disputed. FUTURE DIRECTIONS The World Health Organization indicates that one third of all cancer deaths are preventable and that diet is closely linked to prevention. Based on this idea and epidemiological findings, attention has centered on dietary phytochemicals as an effective intervention in cancer development. However, an unequivocal link between diet and cancer has not been established. Thus, identifying cancer preventive dietary agents with specific molecular targets is essential to move forward toward successful cancer prevention.
Electricity Prices, Income and Residential Electricity Consumption

In recent years, aiming to reduce the Greenhouse Gas pollution and promote energy efficiency and conservation among consumers’ energy use, price policies and price changes derived from environmental regulations have played a more important role. In this paper, using the most recent annual state-level panel data for 48 states, I estimate a dynamic partial adjustment model for electricity demand elasticities on price and income in the residential sector. My analysis reveals that in the short run, one unit price increase will only lead to 0.142 unit of reduction in electricity use after controlling for the endogeneity of electricity price. Thus, raising the energy price in the short run will not give consumers much incentive to adjust their appliances and make energy conservation investments to reduce electricity use. However, in the long run, one unit price increase will lead to almost one unit consumption reduction when the endogeneity of electricity price is controlled. Therefore, in the long run, facing the higher electricity price induced from regulation policies, consumers are more likely to adjust their stock of appliances and make energy efficiency investments, which lowers their electricity consumption. In addition, we find new evidence that states of relatively higher income levels are more price elastic than states of relatively lower income levels in both the short run and long run. Thus, for states of higher per capita GDP, raising the electricity price may be more effective to ensure a cut in consumption. JEL Classification: L52, Q41, Q48, Q5
THE IMPACT OF FACTORS INFLUENCING EMPLOYMENT/REEMPLOYMENT PROBABILITY ON THE ROMANIAN LABOR MARKET

The impact of factors influencing employment/reemployment probability for registered unemployed people in Romania is analyzed using multinomial logistic regression. The empirical analysis is based on a nationally representative dataset of 1851288 completed unemployment spells gathered from the National Agency of Employment Romania for the period January 1st 2008 - December 31st 2010.
Funding accessibility for minority entrepreneurs: an empirical analysis

Purpose – The purpose of this paper is to examine what factors affect entrepreneurs with minority background to access public financial institutions’ funds in initiating and developing their new ventures. Following the signal theory, social capital theory and the liability of newness perspective, the effect of demographic characteristics of entrepreneurs were investigated and the differences between ethnic minority and non-minority entrepreneurs’ access to financial institutions’ funds were compared. Design/methodology/approach – This paper draws on the data of 2,119 high technology and non-high technology firms from the Kauffman foundation survey. The empirical analysis was focussed on the characteristics of entrepreneurs of these new ventures and the nature of the financial arrangements of these businesses to test the theoretical framework. Findings – This study provides empirical evidence that ethnic minority entrepreneurs are less likely to access loans from financial institutions than non-minority en.
A Framework for Developing Component-based Applications with Temporal Analysis Capabilities

Reactive system design requires the integration of structural and behavioral requirements with temporal ones (along with V&V activities) to describe the application architecture. This paper describes an implementation framework for component-based applications that provides developers with great control over application concurrency (number of threads and their characteristics), the computational load assigned to them, and allows the temporal analysis of the applications developed with the framework. The paper presents an improved version of a framework previously developed, putting it in the context of a global Model-Driven Software Development approach for developing, analyzing and generating code for reactive applications.
Innovar en los programas de formación para la ocupación

The term of occupation has evolved along history including elements of motivation, well-being and self-realization. The current model of occupation training poses to promote the insertion within the work environment throughout an optimal personal development using innovative actions. This study attempts to: implement a program focused on improving participants’ character strengths and their levels of life satisfaction, well-being, emotional intelligence and self-realization. The program was implemented in a sample of 100 unemployed people of Lleida. The measures used in the study were: VIA-IS scale (Peterson & Seligman, 2004), the subjective happiness scale (Lyubomirsky & Lepper, 1999), TMMS-24 (Salovey, et al., 1995) and the satisfaction with life scale (Diener et al., 1985).
Translational research in gliomas: Quo Vadis?

So, whatever one's definition of TR is, TR is clearly changing the landscape in the world of glioma neuro-oncology. We are in a rich era of progress relating clinical observations and management with laboratory discoveries and vice versa. Foremost among these symbiotic relationships are developments in imaging, molecular diagnostics, preclinical testing of therapeutics, clinical trials (medical and surgical), stem cells, and tumor banking. Although described by some as the "molecular era" of human brain tumor management, it is probably more accurate to describe it as the era of "translational research. "
The Role of Pollen Tube Reception in Reproductive Isolation

In plants, receptor-like kinases regulate many processes during reproductive and vegetative development. The Arabidopsis subfamily of Catharanthus roseus RLK1-like kinases (CrRLK1Ls) comprises 17 members with a putative extracellular carbohydratebinding malectin-like domain. Only little is known about the functions of these proteins, although mutant analyses revealed a role during cell elongation, polarized growth, and fertilization. However, the molecular nature of the underlying signal transduction cascades remains largely unknown. CrRLK1L proteins are also involved in biotic and abiotic stress response. It is likely that carbohydrate-rich ligands transmit a signal, which could originate from cell wall components, an arriving pollen tube, or a pathogen attack. Thus, post-translational modifications could be crucial for CrRLK1L signal transduction and ligand binding.
Automatic Algorithms for Medieval Manuscript Analysis

Massive digital acquisition and preservation of deteriorating historical and artistic documents is of particular importance due to their value and fragile condition. The study and browsing of such digital libraries is invaluable for scholars in the Cultural Heritage field, but requires automatic tools for analyzing and indexing these datasets. We will describe a set of completely automatic solutions to estimate per-page text leading, to extract text lines, blocks and other layout elements, and to perform query-by-example word-spotting on medieval manuscripts. Those techniques have been evaluated on a huge heterogeneous corpus of illuminated medieval manuscripts of different writing styles, languages, image resolutions, amount of illumination and ornamentation, and levels of conservation, with various problematic issues such as holes, spots, ink bleed-through, ornamentation, and background noise. We also present a quantitative analysis to better assess the quality of the proposed algorithms. By not requiring any human intervention to produce a large amount of annotated training data, the developed methods provide Computer Vision researchers and Cultural Heritage practitioners with a compact and efficient system for document analysis.
Repetitive risk aversion

We propose a reasonable condition, which we call repetitive risk aversion (RRA), to be imposed on any utility function to account for the observed data on the relationship between the degree of absolute risk aversion and wealth. We deduce this condition from the concept of the fear of ruin (Aumann and Kurz 1977) and show it to be equivalent to the behaviorally meaningful condition that the risk premium is increasing at a non-increasing rate with the size of the bet. We drive mixed risk aversion, which is known to be stronger than standard and thus proper risk aversion, from RRA. We present several economic applications of RRA to demonstrate that it delivers better comparative static results.
Modeling the Time Varying Comovement of Asset Returns

Existing multivariate models allowing the covariance matrix to be time varying generally impose strong restrictions on how past shocks can affect the covariance matrix. Yet these restrictions are seldom compared and tested. Furthermore, few studies have examined the existence of asymmetric/leverage effects in covariance, even though there are good reasons to believe they exist and have important implications for portfolio management, derivatives pricing and hedging. In this paper, we introduce a set of robust conditional moment tests to detect misspecification in the covariance matrix, and introduce a general model which nests the four most popular multivariate GARCH models and their natural "asymmetric" extensions. The new model is applied to study the dynamic relation between large and small firm returns. Our results suggest that bad news about large firms can cause volatility in both small and large firm returns, while news about small firms, whether good or bad, has minimal effect on the covariance matrix. The conditional covariance between large firm and small firm returns also tends to increase following bad news about large firms but not bad news about small firms.
How spirituality shapes the practice of community health nurses who work in First Nations communities in British Columbia

In recent years nursing literature has featured a proliferation of discourse pertaining to many aspects of spirituality in nursing. However, there has been a dearth of research related to nurses' personal spirituality and whether or not it helps to shape their nursing practice. This qualitative study explored how spirituality shapes the practice of community health nurses who work in First Nations communities in British Columbia (B.C.). The twelve participants, purposefully sampled, all had at least 2 years experience working in community health in First Nations communities. Using an interpretive descriptive research design, participants were interviewed to explore their lived experiences of spirituality relative to their nursing practice. The analysis of the interview data identified that nurses' spirituality is essential to their practice in terms of "providing care spiritually" versus "providing spiritual care" interventions to their patients as typically depicted in the nursing literature. Moreover, their spirituality is discussed as a pervasive nursing ethic and motivation for patient care that manifests as respect, connectedness, love, acceptance, caring, hope, endurance and compassion towards patients. Furthermore, the findings of this study suggest the integration of community health nurses' spirituality into their nursing practice may contribute to the wider aim of health and healing within First Nations communities. Four major themes are presented as research findings: (a) spirituality influences nurses' ability to remain self aware, open-minded and accepting in relation to others; (b) spirituality as a reflexive approach to grounding one's own nursing practice; (c) spiritual awareness fosters appreciation of the need for community healing, and finally (d) self-
Measurement of factor XIII activity in plasma

Abstract Coagulation factor XIII (FXIII) is converted by thrombin and Ca2+ into an active transglutaminase (FXIIIa) in the final phase of coagulation cascade. Its main function is the mechanical stabilization of fibrin clot and its protection from fibrinolysis by cross-linking of fibrin chains and α2-plasmin inhibitor to fibrin. In non-substituted patients FXIII deficiency is a severe hemorrhagic diathesis, not infrequently with fatal consequences. The main reason for using FXIII assays is the diagnosis of FXIII deficiency. The aim of this review is to provide a comprehensive critical evaluation of the methods reported for the determination of FXIII activity in the plasma. Such methods are based on two principles: 1) measurement of labeled amines incorporated by FXIIIa into a glutamine residue of a substrate protein, 2) monitoring ammonia released from a peptide bound glutamine residue by FXIIIa using NAD(P)H dependent glutamate dehydrogenase indicator reaction. The incorporation assays are sensitive, but cumbersome and time-consuming, they are difficult to standardize and cannot be automated. The ammonia release assays are less sensitive, but quick, well standardized, and can be automated; this type of assay is recommended for the screening of FXIII deficiency. The traditional clot solubility assay should not be used for this purpose.