Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning Solving Procedure for Artificial Neural Network

It is expected that progress toward true artificial intelligence will be achieved through the emergence of a system that integrates representation learning and complex reasoning (LeCun et al. 2015). In response to this prediction, research has been conducted on implementing the symbolic reasoning of a von Neumann computer in an artificial neural network (Graves et al. 2016; Graves et al. 2014; Reed et al. 2015). However, these studies have many limitations in realizing neural-symbolic integration (Jaeger. 2016). Here, we present a new learning paradigm: a learning solving procedure (LSP) that learns the procedure for solving complex problems. This is not accomplished merely by learning input-output data, but by learning algorithms through a solving procedure that obtains the output as a sequence of tasks for a given input problem. The LSP neural network system not only learns simple problems of addition and multiplication, but also the algorithms of complicated problems, such as complex arithmetic expression, sorting, and Hanoi Tower. To realize this, the LSP neural network structure consists of a deep neural network and long short-term memory, which are recursively combined. Through experimentation, we demonstrate the efficiency and scalability of LSP and its validity as a mechanism of complex reasoning.
Canadian Rural/Remote Primary Care Physicians Perspectives on Child/Adolescent Mental Health Care Service Delivery.

INTRODUCTION Primary Care Physicians (PCP) play a key role in the recognition and management of child/adolescent mental health struggles. In rural and under-serviced areas of Canada, there is a gap between child/adolescent mental health needs and service provision. METHODS From a Canadian national needs assessment survey, PCPs' narrative comments were examined using quantitative and qualitative approaches. Using the phenomenological method, individual comments were drawn upon to illustrate the themes that emerged. These themes were further analyzed using chi-square to identify significant differences in the frequency in which they were reported. RESULTS Out of 909 PCPs completing the survey, 39.38% (n = 358) wrote comments. Major themes that emerged were: 1) psychiatrist access, including issues such as long waiting lists, no child/adolescent psychiatrists available, no direct access to child/adolescent psychiatrists; 2) poor communication/continuity, need for more systemized/transparent referral processes, and need to rely on adult psychiatrists; and, 3) referral of patients to other mental health professionals such as paediatricians, psychologists, and social workers. CONCLUSIONS Concerns that emerged across sites primarily revolved around lack of access to care and systems issues that interfere with effective service delivery. These concerns suggest potential opportunities for future improvement of service delivery. IMPLICATIONS Although the survey only had one comment box located at the end, PCPs wrote their comments throughout the survey. Further research focusing on PCPs' expressed written concerns may give further insight into child/adolescent mental health care service delivery systems. A comparative study targeting urban versus rural regions in Canada may provide further valuable insights.
Understanding and improving disk-based intermediate data caching in Spark

Apache Spark is a parallel data processing framework that executes fast for iterative calculations and interactive processing, by caching intermediate data in memory with a lineage-based data recovery from faults. The Spark system can also manage data sets larger than memory capacity by placing some cache or all of them on disks on processing nodes. However, the disadvantage is potential performance degradation due to disk I/O and/or serialization. This study aims to clarify efficient/inefficient use of disks in intermediate data caching in Spark and also to improve the usability of disks for end users. In order to achieve the purpose, influence of disk use in data caching was firstly investigated in various aspects, such as caching options, data abstractions and storage devices. The results indicate that serialization cost is dominant rather than disk I/O in most cases. Secondly, a method of combined use of memory and disk was further evaluated under a high memory pressure. Then the method was improved to avoid an excessive re-caching problem, which achieved at most 20–30% reduction of total execution time under a high memory pressure and did not degrade the performance under a low memory pressure, in our experiment with 4 machine learning benchmarks. Finally, this paper summarizes important factors and potential improvements for efficiently using disks in data caching in Spark.
Alexithymia and depression in the recovery of chronic pain patients: a follow-up study

Abstract Background: Childhood adversities and emotional dysregulation are connected with chronic pain, alexithymia, and depression. Longitudinal studies exploring the impact of their co-occurrence on the pain situation are rare. Aims: The influence of alexithymia, depression, baseline pain situation, and treatment options on the course of chronic pain in a clinical sample was studied. Methods: The baseline data was collected from chronic pain patients (n = 154) before their first pain clinic visit, and the follow-up data after 1 year by self-report questionnaires. Study variables consisted of pain intensity, pain disability, alexithymia (TAS-20), depression (BDI-II), and treatment interventions. Statistical analyses were performed to find out differences between baseline and follow-up, as well as between alexithymic and non-alexithymic patients, and to estimate the effect of the treatment provided. Results: At follow-up, the majority of the patients had pain intensity and disability severe enough to disrupt with their daily living. None of treatment interventions was related to better outcome. Alexithymic patients reported more pain disability and depression at both baseline and at follow-up. The effect of alexithymia on pain disability was mediated by depression. The use of opioids was connected to alexithymia and depressiveness. Alexithymia and depression made a substantial contribution to poorer outcome. Conclusions: Severe pain intensity and disability with depression and alexithymia predicted difficulties in achieving improvement. Depression and alexithymia probably impair compliance with treatment and adherence to interventions. Their co-occurrence with a more severe pain situation and with the use of opioids indicates psychological problems underlying the pain experience.
Calculation of half-life of carcinoembryonic antigen after lung tumour resection: a case report.

Since little is known about carcinoembryonic antigen (CEA) half-life in humans, we followed changes in CEA levels after curative resection of a small bronchial adenocarcinoma in a 54 yr old man with an unusually high preoperative serum CEA level of 1,199 ng.ml-1. Serum CEA followed a four phase curve with an initial increase, attributed to release of CEA from the tumour, a rapid fall during four days (CEA half-life 3.2 days), a slower exponential decay to normal levels during almost three months (CEA half-life 11 days) and eventually maintenance of normal levels for 14 months. These results are consistent with data from animal experiments and a single report on CEA half-life in humans, but CEA half-life seems longer in man than in animals. This observation also suggests that a very high serum CEA level should not in itself preclude curative surgical resection of a primary bronchogenic carcinoma.
The Effect of Income, Health, Education, and Social Capital on Happiness in Indonesia

The purpose of the study is to analyze the effect of income, health, education, and social capital on happiness in Indonesia. The data was taken from National Survey of Social Economic conducted by National Bureau of Statistics of Indonesia in 2012. Ordered probit model was used as estimation technique due to ordinal dependent variable and normal distribution of error assumption. The findings show happiness is affected by absolute income, physical perceived health status, mental health, medium and high level of education, trust in leader, participation on society’s activities, tolerance, and help for and from others. However relative income, gender, household head, junior high school, and trust to neighbors do not have significant effect on happiness. Easterlin paradox does not exist in Indonesia because income has positive impact on happiness. Satisfaction on works, financial, family harmony, and leisure time also have significant effect on happiness. Satisfaction on family harmony is the most important factor than others. From demographic variables, it was known that happiness is not different across gender, household head, and low education people. People who are married, live in urban areas, live outside Java and Bali islands, and have more children are found happier. Happiness-age relationship indicates U-shaped curve. Happiness tends to decrease over time until people reach 51 years old. For all three level of happiness, some predictors do not have significant marginal effect on happiness namely relative income, gender, low education level, and trust to neighbors. Meanwhile the variables of household head and number of infant are not robust.
Limitations in the Use of [2-14C]Acetate for Measuring Gluconeogenesis In Vivo

This study was undertaken to test two assumptions critical for use of [2-14C]acetate to measure gluconeogenesis in vivo. For the assumption that incorporation into glucose of products of [14C]acetate metabolism does not affect the distribution of label within the glucose molecule, we infused [2-14C]acetate in 17 healthy subjects and [3-14C]lactate in 10 healthy subjects and compared the ratio of the resultant specific activities of plasma glucose carbons 1, 2, 5, 6, and 3, 4 obtained with each tracer. The ratio obtained with [2-14C]acetate (2.99 ± 0.07) was significantly different from the ratio obtained with [3-14C]lactate, (3.82 ± 0.2, P < 0.01). Because the model predicts that these ratios should be identical, these results indicate that either the model is incorrect or that metabolism of [14C]acetate to other compounds affects the distribution of the label within the glucose molecule. To test the assumption that plasma 3-OH-butyrate specific activity approximates the specific activity of hepatic intramitochondrial acetyl CoA, we compared the ratio of specific activities of plasma glucose and 3-OH-butyrate obtained in 7 healthy subjects infused with [2-14C]acetate and [2-14C]octanoate. The ratio obtained with [2-14C]acetate (0.18 ± 0.03) was significantly different from that obtained with [2-14C]octanoate, (0.10 ± 0.02), P < 0.001. These results suggest compartmentalization of acetyl CoA within liver mitochondria and indicate that plasma 3-OH-butyrate specific activity may not necessarily approximate intramitochondrial acetyl CoA specific activity during [2-14C]acetate infusion. We conclude that assumptions critical for use of [2-14C]acetate to measure gluconeogenesis in vivo are not valid.
Clonal lymphoproliferation following chronic active Epstein‐Barr virus infection and hypersensitivity to mosquito bites

In order to elucidate the possibility of lymphoproliferation in cases of chronic active Epstein‐Barr virus infection (CAEBV), to clarify the clonality and genotype of proliferating lymphocytes, and to search for the factors that induce lymphoproliferation, we studied 11 cases of CAEBV, using genetical and immunological techniques.
Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation.

BACKGROUND Previous research has shown that smokers have reduced brain and platelet monoamine oxidase B (MAOB) activity. This is probably due to some components of tobacco smoke. When smokers quit, MAOB activity returns to normal. Reduced MAO activity may increase nicotine's addictive potential. AIMS To assess whether lazabemide, a reversible selective MAOB inhibitor, promotes smoking cessation. STUDY DESIGN Double-blind, randomized, placebo-controlled, multicenter phase II study. Placebo, lazabemide 100 mg/day and 200 mg/day were administered for 8 weeks. This was a dose finding, proof-of-concept, exploratory study. SETTING General practices and anti-smoking clinics in France and Belgium. PARTICIPANTS Smokers smoking > or=15 cigarettes per day and motivated to quit. MAIN OUTCOME MEASURE Sustained abstinence during the last 4 weeks of the study. FINDINGS The study was discontinued prematurely by the sponsor before randomization of the planned 420 smokers because of liver toxicity observed in other indications. Data of 330 randomized subjects could be analysed. Sustained abstinence during the last 4 weeks of treatment was 9%, 11% and 17% in the intent-to-treat population [P for trend: 0.036 (one-sided)]; 11%, 14% and 21% in the intent-to-treat population of smokers without those excluded because of discontinuation of the study [n = 262, P for trend: 0.02 (one-sided)], and 19%, 27% and 35% in completers [P for trend: 0.03 (one-sided)], in the placebo, lazabemide 100 mg/day and lazabemide 200 mg/day groups, respectively. Point prevalence abstinence (intent-to-treat population) at the end of treatment (week 8) was 17%, 19% and 30% in the placebo, lazabemide 100 mg/day and lazabemide 200 mg/day groups, respectively (placebo vs. lazabemide 200 mg/day: P = 0.01, one-sided). No treatment emergent major adverse event occurred. More nausea and insomnia were reported with lazabemide than with placebo. CONCLUSIONS MAOB inhibitors are promising treatments as an aid in smoking cessation. There may be an interest to develop MAOB inhibitors with an acceptable toxicity profile. Further studies may associate MAOB inhibitors with nicotine replacement therapies to increase therapeutic efficacy.
Sense of Coherence and Quality of Life in Women With and Without Irritable Bowel Syndrome

BackgroundDespite ongoing physical and psychological distress, little is known about sense of coherence (SOC) and holistic quality of life (QOL) in women with irritable bowel syndrome (IBS). ObjectivesThe purposes of this study were to (a) describe and compare SOC and holistic QOL of women with and without IBS, and (b) examine the relationships among SOC, holistic QOL, and gastrointestinal (GI) and psychological distress symptoms. MethodA two-group comparison design was used to test the study hypotheses that women with IBS would have lower SOC and holistic QOL than control women without IBS, and that SOC and holistic QOL would be inversely related to GI and psychological distress. A total of 324 women were studied (n = 235 with IBS, n = 89 controls). Measures included the 13-item SOC Questionnaire, Modified Flanagan QOL Scale, Bowel Disease Questionnaire, and Symptom-Checklist-90-R. ResultsBoth SOC and holistic QOL were lower in women with IBS (p <.001). Correlations between SOC and global distress, depression, anxiety, and somatization without GI symptoms were moderately and inversely related (r = −.64, −.64, −.53, and −.31, respectively; p <.001) in the total sample. Relationships between holistic QOL and psychological distress indicators were universally of lower magnitude (r = −.56 to −.27, p <.001). The only GI symptom indicator significantly related to SOC and holistic QOL was alternating constipation and diarrhea (τ = −.21 and −.17, respectively; p <.001). DiscussionWomen with IBS have a reduced SOC and holistic QOL when compared to women without IBS. It remains to be determined whether interventions targeted at enhancing SOC and holistic QOL can impact the psychological distress associated with IBS.
Proteome-wide identification of family member-specific natural substrate repertoire of caspases

Caspases are proteolytic enzymes that are essential for apoptosis. Understanding the many discrete and interacting signaling pathways mediated by caspases requires the identification of the natural substrate repertoire for each caspase of interest. Using an amplification-based protein selection technique called mRNA display, we developed a high-throughput screen platform for caspase family member specific substrates on a proteome-wide scale. A large number of both known and previously uncharacterized caspase-3 substrates were identified from the human proteome. The proteolytic features of these selected substrates, including their cleavage sites and specificities, were characterized. Substrates that were cleaved only by caspase-8 or granzyme B but not by caspase-3, were readily selected. The method can be widely applied for efficient and systematic identification of the family member specific natural substrate repertoire of any caspase in an organism of interest, in addition to that of numerous other proteases with high specificity.
Investigation on the Dynamic Performances of a Doubly Salient Flux Memory Motor under On-Line Flux Regulation for Electric Vehicles

By incorporating the magnetization level of AINiCo permanent magnets (AINiCo-PMs) into doubly salient permanent magnet (DSPM) motor, a new doubly salient flux memory (DSFM) motor is proposed. The magnetization level of permanent magnets (PMs) in the motor can be easily regulated by a temporary dc current pulse and then be memorized automatically. So the resulting new memory motor can not only retain high power density, but also offer efficient air-gap flux control. The purpose of this paper is to build a simulation model of speed control system in DSFM motor, where dynamic performances are investigated in details at different magnetic flux levels. The simulation results shows that the DSFM motor has the advantages of the wide speed range at high speed operation and high torque density at low speed operation, which makes it suitable for the application in electric vehicles (EVs).
Muscle fiber characteristics, satellite cells and soccer performance in young athletes.

This study is aimed to examine the muscle fiber type, composition and satellite cells in young male soccer players and to correlate them to cardiorespiratory indices and muscle strength. The participants formed three Groups: Group A (n = 13), 11.2 ± 0.4yrs, Group B (n=10), 13.1 ± 0.5yrs and Group C (n = 9), 15.2 ± 0.6yrs. Muscle biopsies were obtained from the vastus lateralis. Peak torque values of the quadriceps and hamstrings were recorded and VO2max was measured on the treadmill. Group C had lower type I percentage distribution compared to A by 21.3% (p < 0.01), while the type IIA relative percentage was higher by 18.1% and 18.4% than in Groups A and B (p < 0.05). Groups B and C had higher cross-sectional area (CSA) values in all fiber types than in Group A (0.05 < p < 0.001). The number of satellite cells did not differ between the groups. Groups B and C had higher peak torque at all angular velocities and absolute VO2max in terms of ml·min(-1) than Group A (0.05 < p < 0.001). It is concluded that the increased percentage of type IIA muscle fibers noticed in Group C in comparison to the Groups A and B should be mainly attributed to the different workload exercise and training programs. The alteration of myosin heavy chain (MHC) isoforms composition even in children is an important mechanism for skeletal muscle characteristics. Finally, CSA, isokinetic muscle strength and VO2max values seems to be expressed according to age. Key PointsFifteen years old soccer players have higher IIA percentage distribution than the younger players by approximately 18%. The age and the training status play a crucial role in muscle fibers co-expression.Specific training in young athletes seems to alter significantly the muscular metabolic profile.
Culture-Laden Imports: International Market Entry and Cultural Taboos

This empirical study investigates American market responses to a Spanish product that is strongly culture-laden and may violate cultural taboos. Surveys were conducted in two contrasting US universities in Arkansas and California. Contrasting student majors were also chosen: Art and Business. The product is a life-sized baby doll, designed to be breast-fed rather than bottle-fed, which highlights the benefits and normality of breast-feeding babies. Although this product is popular in its original European market, US media accounts suggested strongly negative morality-based American reactions. This study found a strong overall non-acceptance of this product in all groups, but with significant differences between groups. Results quantify the market reaction and illuminate its cultural basis by comparing responses between two culturally different regions, two contrasting college majors, different genders, and different ethnicities. In doing so, this study helps to break new ground in the international marketing of culture-laden products.
Cancer pain: part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners.

OBJECTIVE This discussion document about the management of cancer pain is written from the pain specialists' perspective in order to provoke thought and interest in a multimodal approach to the management of cancer pain, not just towards the end of life, but pain at diagnosis, as a consequence of cancer therapies, and in cancer survivors. It relates the science of pain to the clinical setting and explains the role of psychological, physical, interventional and complementary therapies in cancer pain. METHODS This document has been produced by a consensus group of relevant health care professionals in the United Kingdom and patients' representatives making reference to the current body of evidence relating to cancer pain. In the first of two parts, pathophysiology, oncological, pharmacological, and psychological treatment are considered. CONCLUSIONS It is recognized that the World Health Organization (WHO) analgesic ladder, while providing relief of cancer pain towards the end of life for many sufferers worldwide, may have limitations in the context of longer survival and increasing disease complexity. To complement this, it is suggested that a more comprehensive model of managing cancer pain is needed that is mechanism-based and multimodal, using combination therapies including interventions where appropriate, tailored to the needs of an individual, with the aim to optimize pain relief with minimization of adverse effects.
A finite-element analysis of surface wave plasmas

This paper describes a finite-element analysis of surface microwaves coupled to a cold nonmagnetized plasma for chemical vapor deposition (CVD). The microwave-plasma coupling is taken into account by introducing the frequency-dependent permittivity. The computed resonant modes of the surface wave on the interface between the dielectric and plasma in a cylindrical vessel are shown to be in good agreement with the theoretical ones. Moreover, the computed field distribution for a waveguide loaded cylindrical vessel agrees well with that computed by the finite-difference time-domain (FDTD) method.