Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive sub-Nyquist hardware prototype of a collocated MIMO radar

We present the design and hardware implementation of a radar prototype that demonstrates the principle of a sub-Nyquist collocated multiple-input multiple-output (MIMO) radar. The setup allows sampling in both spatial and spectral domains at rates much lower than dictated by the Nyquist sampling theorem. Our prototype realizes an X-band MIMO radar that can be configured to have a maximum of 8 transmit and 10 receive antenna elements. We use frequency division multiplexing (FDM) to achieve the orthogonality of MIMO waveforms and apply the Xampling framework for signal recovery. The prototype also implements a cognitive transmission scheme where each transmit waveform is restricted to those pre-determined subbands of the full signal bandwidth that the receiver samples and processes. Real-time experiments show reasonable recovery performance while operating as a 4 × 5 thinned random array wherein the combined spatial and spectral sampling factor reduction is 87.5% of that of a filled 8 × 10 array.
Odor assessment of automobile cabin air by machine olfaction

Odor quality in the cabin air of automobiles can be a significant factor in the decision to purchase a vehicle and the overall customer satisfaction with the vehicle over time. Current standard practice uses a human panel to rate the vehicle cabin odors on intensity, irritation, and pleasantness. However, human panels are expensive, time-consuming and complicated to administer. To address this issue, we have developed a machine olfaction approach to assess odors inside automobiles for the purpose of enhancing or replacing the human panel by evaluating the correlation between the system performance and a trained human panel. Our approach employs an ion-mobility spectrometer and a photoionization detector for measuring volatile organic compounds inside automobiles. Our olfactory system achieves good correlations (range from 0.72 to 0.84) with a trained human panel using predictive models generated by linear regression and cross-validation. Our results support the feasibility of replacing human panel assessments by a machine olfaction system.
Effective Protection Against Experimental Taenia solium Tapeworm Infection in Hamsters by Primo-Infection and by Vaccination with Recombinant or Synthetic Heterologous Antigens

The disease caused by Taenia solium is progressively being recognized as a growing global threat for public human health and pig husbandry that requires the development of effective control measures. A central participant in the taeniasis/cysticercosis transmission network is the human carrier of the adult tapeworm because of its great potential in spreading the infection. Herein, evidence is presented that a primary infection of golden hamsters with orally administered T. solium cysticerci improved the host's resistance against a secondary infection. Likewise, previous vaccination increased the hamster's resistance. Similar high levels of protection (>78%) were induced by systemic or oral vaccination with the S3Pvac anticysticercosis synthetic peptide vaccine or the highly immunogenic recombinant chimera based on the protective peptide KETc1 bound to Brucella spp. lumazine synthase (BLS-KETc1). Increased resistance after primo-infection and vaccination possibly results from changes in the immune conditions prevailing in the host's intestine. The contribution to protection from the KETc1 and BLS epitopes in a chimeric vaccine is under study. Preventive vaccination of definitive hosts of T. solium against the tapeworm, the most relevant step in the taeniasis/cysticercosis transmission, may greatly impact the dynamics of endemic disease and has not been studied or tried previously.
Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro.

OBJECTIVE To elucidate the role of bone morphogenetic protein 6 (BMP-6) in human articular cartilage, we investigated whether BMP-6 is expressed in adult human articular chondrocytes and analyzed the potential stimulatory effects of BMP-6 on these cells. In addition, we investigated whether osteoarthritic (OA) and normal cartilage chondrocytes behave differently. METHODS Endogenous expression of the BMP-6 gene was examined by reverse transcription-polymerase chain reaction. BMP-6 protein was detected by Western immunoblotting. Chondrocytes were grown as monolayer cultures for 7 days in a chemically defined serum-free medium, in the absence or presence of recombinant BMP-6. Proteoglycan (PG) synthesis was measured by (35)S-sulfate incorporation into newly synthesized macromolecules. Cell proliferation was assessed by (3)H-thymidine incorporation. RESULTS BMP-6 was expressed in both healthy and OA chondrocytes at the messenger RNA and protein levels. Total PG synthesis was significantly increased after BMP-6 stimulation of healthy (mean +/- SEM 191 +/- 11%; P < 0.001) and OA (150 +/- 25%; P < 0.03) chondrocyte cultures. A direct comparison between healthy and OA samples revealed no significant difference. The proliferation rates of normal and OA chondrocytes were not affected by BMP-6 treatment. CONCLUSION BMP-6 is endogenously expressed in chondrocytes obtained from OA and normal adult human articular cartilage. Furthermore, BMP-6 has the potential to stimulate total PG synthesis in human articular chondrocytes derived from normal as well as OA joints. We conclude that the presence of BMP-6 in adult human articular cartilage indicates a functional role for this growth factor in the maintenance of joint integrity.
Improvement in the Thermostability of d-Psicose 3-Epimerase from Agrobacterium tumefaciens by Random and Site-Directed Mutagenesis

ABSTRACT The S213C, I33L, and I33L S213C variants of d-psicose 3-epimerase from Agrobacterium tumefaciens, which were obtained by random and site-directed mutagenesis, displayed increases of 2.5, 5, and 7.5°C in the temperature for maximal enzyme activity, increases of 3.3-, 7.2-, and 29.9-fold in the half-life at 50°C, and increases of 3.1, 4.3, and 7.6°C in apparent melting temperature, respectively, compared with the wild-type enzyme. Molecular modeling suggests that the improvement in thermostability in these variants may have resulted from increased putative hydrogen bonds and formation of new aromatic stacking interactions. The immobilized wild-type enzyme with and without borate maintained activity for 8 days at a conversion yield of 70% (350 g/liter psicose) and for 16 days at a conversion yield of 30% (150 g/liter psicose), respectively. After 8 or 16 days, the enzyme activity gradually decreased, and the conversion yields with and without borate were reduced to 22 and 9.6%, respectively, at 30 days. In contrast, the activities of the immobilized I33L S213C variant with and without borate did not decrease during the operation time of 30 days. These results suggest that the I33L S213C variant may be useful as an industrial producer of d-psicose.
Investigating the influence of virtual peers as dialect models on students' prosodic inventory

Children who speak non-standard dialects of English show reduced performance not just in language-oriented topics in school but also in math and science. Technological solutions have been rare exactly because of the nonmainstream nature of their talk, and hence the difficulty in automatically recognizing their speech and responding to it with, for example, computer tutors. In order to work towards overcoming this achievement gap, in this work we investigate African American students’ prosodic inventories in different contexts as a first-step towards building a system that will be able to automatically recognize, and respond to, the dialect in which a child is speaking. We presented children with recordings of a peer (confederate) speaking in either African American English (AAE) or Mainstream American English (MAE) during both a social task and a science task. We found that children showed decreased prosodic variation and peak slopes during speech segments which did not contain AAE features, resulting in more monotone and breathy utterances than when they are speaking in AAE. We also found that children who were speaking with a “peer” who uses AAE have increased articulation rates, energy, and pitch variation. We discuss potential interpretations of these results that are important to the design of a system to support linguistic diversity and decrease the achievement gap.
Concept abduction and contraction for semantic-based discovery of matches and negotiation spaces in an e-marketplace

In this paper we present a Description Logic approach to extended matchmaking between Demands and Supplies in an Electronic Marketplace, which allows the semantic-based treatment of negotiable and strict requirements in the description.To this aim we exploit two novel non-standard Description Logic inference services, Concept Contraction -which extends satisfiability-and Concept Abduction -which extends subsumption.Based on these services we devise algorithms to find negotiation spaces and to determine the quality of a possible match, also in the presence of a distinction between strictly required and optional elements.
Person-Centered Profiles Among Treatment-Seeking Children and Adolescents with Anxiety Disorders

Latent profile analysis (LPA) was used to derive homogeneous subgroups within the Child/Adolescent Anxiety Multimodal Study sample (N = 488; 7–17 years, M = 10.69, SD = 2.80) and examine whether class membership predicted or moderated treatment response. Subgroups were identified on baseline multi-informant measures of variables most consistently associated with outcome (youth anxiety/diagnosis, impairment, family psychopathology/functioning). Subgroup membership was examined as a predictor/moderator of outcome across the four treatment conditions (CBT, Sertraline, CBT+Sertraline, pill placebo) at posttreatment (12 weeks) and open-extension follow-up (24 weeks). Four subgroups emerged: mild symptoms/impairment, moderate symptoms/impairment, moderate symptoms/impairment with family dysfunction/parental psychopathology, and severe symptoms/impairment. There were significant between-class differences on socioeconomic status (SES; lower reported SES in the moderate with family dysfunction/parental psychopathology class compared to the mild and moderate class) and age (older age in the severe symptoms class compared to the other three classes). Youth in the mild symptoms/impairment class showed lower posttreatment anxiety across conditions but reported significantly lower symptom severity at baseline. Controlling for demographic differences, response to treatment type did not differ across classes. Analyses indicate that elevated family dysfunction/parental psychopathology clusters primarily within one subgroup of anxious youth rather than mapping onto symptom severity, highlighting the utility of LPA for clarifying within-person combinations of predictor/moderator variables. Implications for development of interventions targeting class-relevant variables are discussed.
Online stochastic matching: online actions based on offline statistics

We consider the online stochastic matching problem proposed by Feldman et al. [4] as a model of display ad allocation. We are given a bipartite graph; one side of the graph corresponds to a fixed set of bins and the other side represents the set of possible ball types. At each time step, a ball is sampled independently from the given distribution and it needs to be matched upon its arrival to an empty bin. The goal is to maximize the size of the matching. We present an online algorithm for this problem with a competitive ratio of 0.702. Before our result, algorithms with a competitive ratio better than 1−1/e were known under the assumption that the expected number of arriving balls of each type is integral. A key idea of the algorithm is to collect statistics about the decisions of the optimum offline solution using Monte Carlo sampling and use those statistics to guide the decisions of the online algorithm. We also show that no online algorithm can have a competitive ratio better than 0.823.
Acetate Correction for Postabsorption Metabolism Does Not Improve the [13C]Mixed Triacylglycerol Breath Test

Objective: The [13C]mixed triacylglycerol (MTG) breath test is a noninvasive measure of fat digestion. After absorption and oxidation, 13C appears in breath CO2. Recovery is no more than 50% in healthy subjects because of sequestration of acetate in intermediary metabolism. The aims of this study were to investigate interindividual variation and postabsorptive metabolism of MTG using oral [1-13C]acetate and to examine the use of correction factors to account for the “missing” label. Patients and Methods: [13C]mixed triacylglycerol and [1-13C]acetate breath tests were performed on 8 healthy adults, 9 healthy children and 3 children with cystic fibrosis. Breath was sampled for 6 hours on each occasion. The enrichment of 13CO2 in breath was measured by isotope ratio mass spectrometry. Cumulative percentage dose recovered 13CO2 during the MTG test was corrected for label absorbed, but not completely oxidized using the cumulative percentage dose recovered during the acetate test. Results: Mean recovery of 13C during the [13C]MTG test with an acetate correction was close to 100% in healthy subjects: 103.1% (SD, 11.6%) in adults and 98.9% (SD, 30.3%) in children, but the wide variance indicated that some of the assumptions governing the use of acetate corrections with oral tracers may not be valid. Conclusion: The need to perform 2 tests, variation in physical activity between tests and differences in intermediary metabolism preclude the use of acetate correction factors when using [13C]MTG to assess intraluminal fat digestion, especially in children.
Predictors of Incident Heart Failure in a Large Insured Population: A One Million Person-Year Follow-Up Study

Background—Studies on the incidence and predictors of heart failure (HF) are often restricted to elderly persons or identify only inpatient cases. Methods and Results—We determined the incidence and predictors of new HF diagnosed in either outpatient or inpatient settings, among 359 947 women and men (age ≥18 years) insured by Kaiser Permanente Georgia at any time during calendar years 2000 to 2005. Subjects were free of HF at baseline, and incident HF was identified with ICD-9 codes (1 inpatient or 2 outpatient HF visits). We developed multivariable Cox models to assess the association of antecedent factors (coronary heart disease, hypertension, diabetes mellitus, atrial fibrillation, and valvular heart disease) with incident HF. Separate models were created for each sex and for newly diagnosed HF in outpatient or inpatient settings. There were 4001 incident HF cases (50% women and 48% in subjects <65 years old), during 1 015 794 person-years of follow-up. The incidence rate of HF was greater in men than in women (4.24 versus 3.68 per 1000 person-years) but was stable across the study interval in both sexes. Two thirds of incident HF cases from this population occurred in outpatients. These 5 antecedent factors and age yielded excellent discrimination for incident HF in both outpatients and inpatients and in both sexes (C >0.85 in all models). Conclusions—Common modifiable risk factors accurately discriminate women and men at risk for HF diagnosed in either outpatient or inpatient settings. Approximately two thirds of new HF cases in our insured population were diagnosed in outpatients; more research is needed to characterize these subjects and their prognosis.
Conceptual Structure and the Structure of Concepts: A Distributed Account of Category-Specific Deficits

We present a new account of the fine-grained structure of semantic categories derived from neuropsychological, behavioral, and developmental data. The account places theoretical emphasis on the functions of the referents of concepts. We claim (i) that the distinctiveness of functional features correlated with perceptual features varies across semantic domains; and (ii) that category structure emerges from the complex interaction of these variables. The representational assumptions that follow from these claims make strong predictions about what types of semantic information are preserved in patients showing category-specific deficits following brain damage. These claims are illustrated with a connectionist simulation which, when damaged, shows patterns of preservation of distinctive and shared functional and perceptual information which varies across semantic domains. The data model both dissociations between knowledge for artifacts and for living things and recent neuropsychological evidence concerning the robustness of functional information in the representation of concepts.
Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium

OBJECTIVES To follow up mortality and cancer incidence in a cohort potentially exposed to cadmium and to perform a geographical (ecological) analysis to further assess the health effects of potential exposure to cadmium. METHODS The English village of Shipham has very high concentrations of cadmium in the soil. A previous cohort study of residents of Shipham in 1939 showed overall mortality below that expected, but a 40% excess of mortality from stroke. This study extends the follow up of the cohort for mortality to 1997, and includes an analysis of cancer incidence from 1971 to 1992, and a geographical study of mortality and cancer incidence. Standardised mortality and incidence ratios (SMRs and SIRs) were estimated with regional reference rates. Comparisons were made with the nearby village of Hutton. RESULTS All cause cohort mortality was lower than expected in both villages, although there was excess cancer incidence in both Shipham (SIR 167, 95% confidence interval (95% CI) 106 to 250) and Hutton (SIR 167, 95% CI 105 to 253). There was an excess of mortality from hypertension, cerebrovascular disease, and nephritis and nephrosis, of borderline significance, in Shipham (SMR 128, 95% CI 99 to 162). In the geographical study, all cause mortality in Shipham was also lower than expected (SMR 84, 95% CI 71 to 100). There was an excess in genitourinary cancers in both Shipham (SIR 160, 95% CI 107 to 239) and Hutton (SIR 153, 95% CI 122 to 192). CONCLUSION No clear evidence of health effects from possible exposure to cadmium in Shipham was found despite the extremely high concentrations of cadmium in the soil.
Foot Pose Estimation Using an Inertial Sensor Unit and Two Distance Sensors

There are many inertial sensor-based foot pose estimation algorithms. In this paper, we present a methodology to improve the accuracy of foot pose estimation using two low-cost distance sensors (VL6180) in addition to an inertial sensor unit. The distance sensor is a time-of-flight range finder and can measure distance up to 20 cm. A Kalman filter with 21 states is proposed to estimate both the calibration parameter (relative pose of distance sensors with respect to the inertial sensor unit) and foot pose. Once the calibration parameter is obtained, a Kalman filter with nine states can be used to estimate foot pose. Through four activities (walking, dancing step, ball kicking, jumping), it is shown that the proposed algorithm significantly improves the vertical position estimation.
Trajectory optimization of mechanical hybrid systems using SUMT

The aim of this report is to propose a unified framework for the determination of non-smooth trajectories for structure-variant mechanical systems along with a computational scheme. The benefits to represent the dynamics as a measure-differential inclusion are presented. The optimal control problem is transcribed into a nonlinear programming problem (NLP) and transformed from the infinite dimensional representation into a finite dimensional representation. The relation to bilevel programming is established. A numerical scheme is proposed for the determination of the state and costate trajectories, which can bear discontinuities and set-valuedness
WAGR(O?) syndrome and congenital ptosis caused by an unbalanced t(11;15)(p13;p11.2)dn demonstrating a 7 megabase deletion by FISH

Aniridia usually occurs in isolation, but may also occur as part of the WAGR contiguous gene deletion syndrome, which includes Wilms tumor, aniridia, genitourinary abnormalities, and mental retardation. The aniridia and predisposition for Wilms tumor seen in WAGR are caused by haploinsufficiency for PAX 6 and WT1, respectively. We present a female infant with aniridia, bilateral ptosis, bilateral posterior capsular cataracts, nystagmus, left‐sided glaucoma, microcephaly, mild unilateral hydronephrosis, poor linear growth, and gross motor delay consistent with a clinical diagnosis of WAGR syndrome. In addition, weight‐for‐height ratio at 12 months is at the 94th centile, raising the possibility of a diagnosis of WAGRO (WAGR + Obesity). Chromosome analysis revealed a translocation (11;15)(p13;p11.2) which has not been previously associated with a diagnosis of WAGR. Subsequent clinical WAGR fluorescent in situ hybridization (FISH) analysis demonstrated a deletion of 11p13 including PAX6 and WT1. A complete FISH‐mapping of the breakpoints on chromosome 11 revealed a 7 Mb deletion within 11p13–11p14. The patient is examined in light of other reported patients with deletions and/or translocations involving the regions between 11p12 → 11p14 including patients with WAGR + obesity (WAGRO) as well as with other reported patients with aniridia and congenital ptosis. © 2006 Wiley‐Liss, Inc.
A pilot study of ICG laser therapy of acne vulgaris: Photodynamic and photothermolysis treatment

The near‐infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy. In application to skin appendages, a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser phototherapy in combination with topical application of ICG suggested for soft and thermal treatment of acne vulgaris.
Molecular characterization and expression analysis of CSαβ defensin genes from the scorpion Mesobuthus martensii

Defensins are important components of innate host defence system against bacteria, fungi, parasites and viruses. Here, we predicted six potential defensin genes from the genome of the scorpion Mesobuthus martensii and then validated four genes from them via the combination of PCR and genomic sequence analysis. These four scorpion defensin genes share the same gene organization and structure of two exons and one phase-I intron with the GT-AG rule. Conserved motif and phylogenetic analysis showed that they belonged to the members of the invertebrate cysteine-stabilized α-helix/β-sheet motif defensin (CSαβ) defensin family. All these four CSαβ defensin genes have the expression feature of constitutive transcription (CON) by the whole scorpion infection model, promoter sequence analysis and dual luciferase assays. Further evolution and comparison analysis found that the invertebrate CSαβ defensin genes from most of arachnids and mollusks appear to share the expression pattern of CON, but those from insects and lower invertebrates (nematodes, annelids, cnidarians and sponges) seem to have identical inducible transcription (IND) after being challenged by microorganisms. Together, we identified four scorpion CSαβ defensin genes with the expression feature of CON, and characterized the diversified expression patterns of the invertebrate CSαβ defensin genes, which will shed insights into the evolution of the invertebrate CSαβ defensin genes and their expression patterns.