Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyzing the Influence of Instant Messaging on User Relationship Estimation

Recent years have seen a plethora of new mobile social networking services, given the widespread and ubiquitous availability of smartphones. However, from a user's perspective, two fundamental problems underlie these services: Undesired interruptions and privacy violations. Understanding user relationships can help smartphones to provide appropriate decision support for improved notification management and content sharing, thus mitigating these negative effects. In this work, we investigate the influence of mobile instant messaging (IM) services in estimating the type and strength of user relationships. To this end, we implemented an Android-based application to gather users' historical communication data and ran a study to collect manual assessments for each smartphone contact. Our user study shows that friends and hobby-related contacts tend to communicate more using IM services, whereas family and work-related contacts tend to use calls. Furthermore, our machine learning models estimate the social circles with an average accuracy of 77%, and distinguish between strong and weak relationships with an average accuracy of 76%, therein.
Scatter Component Analysis: A Unified Framework for Domain Adaptation and Domain Generalization

This paper addresses classification tasks on a particular target domain in which labeled training data are only available from source domains different from (but related to) the target. Two closely related frameworks, domain adaptation and domain generalization, are concerned with such tasks, where the only difference between those frameworks is the availability of the unlabeled target data: domain adaptation can leverage unlabeled target information, while domain generalization cannot. We propose Scatter Component Analyis (SCA), a fast representation learning algorithm that can be applied to both domain adaptation and domain generalization. SCA is based on a simple geometrical measure, i.e., scatter, which operates on reproducing kernel Hilbert space. SCA finds a representation that trades between maximizing the separability of classes, minimizing the mismatch between domains, and maximizing the separability of data; each of which is quantified through scatter. The optimization problem of SCA can be reduced to a generalized eigenvalue problem, which results in a fast and exact solution. Comprehensive experiments on benchmark cross-domain object recognition datasets verify that SCA performs much faster than several state-of-the-art algorithms and also provides state-of-the-art classification accuracy in both domain adaptation and domain generalization. We also show that scatter can be used to establish a theoretical generalization bound in the case of domain adaptation.
Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer.

Gene therapy may be an effective approach to thyroid carcinoma refractory to conventional treatment. A transcriptionally targeted retroviral vector for gene therapy of thyroid carcinomas was generated replacing the viral enhancer with the enhancer sequence of the human thyroglobulin (TG) gene, yielding a chimeric long-terminal repeat. The TG enhancer was used to drive the expression of either a reporter gene (beta-galactosidase) or two therapeutic genes, i.e. the prodrug-activating enzyme thymidine kinase of herpes simplex virus (HSV-TK) and human IL-2, separated by an internal ribosome entry site. The corresponding vector having an unmodified long-terminal repeat was used as control. The targeted vector allowed selective transgene expression and cell killing in differentiated thyroid tumor cells but not in anaplastic thyroid carcinoma cells and nonthyroid cells, as demonstrated by quantitative RT-PCR and cytotoxicity assays. Nude mice injected with tumor cells underwent near complete or complete regression of tumors transduced with the control vector after ganciclovir treatment. On the other hand, infection with the thyroid-specific vector led to regression only of TG-expressing tumors. In addition, tumors expressing human IL-2 showed significant growth retardation, compared with nontransduced tumors while exhibiting signs of necrosis and presence of an inflammatory infiltrate. However, HSV-TK/IL-2 plus ganciclovir was significantly more efficient than HSV-TK/IL-2 alone in eradicating tumor masses. Our results indicate that replacement of viral enhancer with TG enhancer confers selectivity of transgene expression in thyroid cells. Thus, the combined thyroid-specific expression of two therapeutic genes (cytokine and suicide genes), although a safe tumor-targeted treatment, would allow an increased anticancer effect.
Low-Cost Channel Estimation Algorithm for DRM Receiver

—In this paper, we consider a digital radio mondiale (DRM) system using orthogonal frequency division multiplexing (OFDM) with coherent detection at the receiver. The DRM pilots are two-dimensional distribution, linear interpolation and Wiener filter interpolation respectively used in the time and frequency domain as the channel estimation algorithm. We propose a low-complexity improved Wiener filter coefficient algorithm to estimate the OFDM channels. Our proposed algorithm differs from traditional algorithms in two ways. Firstly, we divide the DRM pilots into n groups to estimate the channel responses of corresponding OFDM subcarriers (instead of exploiting the whole pilot at the same time in traditional algorithms). Secondly, we utilize the uniform distribution characteristic of the DRM pilots to reduce the number of Wiener filter coefficients, and this effectively leads to a reduction in computation complexity. In addition, simulation results are also presented to gain further insights.
Neutrophils in Cystic Fibrosis Display a Distinct Gene Expression Pattern

We compared gene expression in blood neutrophils (polymorphonuclear leukocytes, or PMNs) collected from healthy subjects with those of cystic fibrosis (CF) patients devoid of bacterial colonization. Macroarray analysis of 1050 genes revealed upregulation of 62 genes and downregulation expression of 27 genes in CF blood PMNs. Among upregulated genes were those coding for vitronectin, some chemokines (particularly CCL17 and CCL18), some interleukin (IL) receptors (IL-3, IL-8, IL-10, IL-12), all three colony-stimulating factors (G-, M-, GM-CSF), numerous genes coding for molecules involved in signal transduction, and a few genes under the control of γ-interferon. In contrast, none of the genes coding for adhesion molecules were modulated. The upregulation of six genes in CF PMNs (coding for thrombospondin-1, G-CSF, CXCL10, CCL17, IKKε, IL-10Ra) was further confirmed by qPCR. In addition, the increased presence of G-CSF, CCL17, and CXCL10 was confirmed by ELISA in supernatants of neutrophils from CF patients. When comparison was performed between blood and airway PMNs of CF patients, there was a limited difference in terms of gene expression. Only the mRNA expression of amphiregulin and tumor necrosis factor (TNF) receptor p55 were significantly higher in airway PMNs. The presence of amphiregulin was confirmed by ELISA in the sputum of CF patients, suggesting for the first time a role of amphiregulin in cystic fibrosis. Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells.
Results of a Preliminary Clinical Trial on a Multiple Channel Cochlear Prosthesis

Speech discrimination testing was carried out under clinical trial conditions for eight profoundly postlingually deaf adults to assess the efficacy of a newly developed 22-channel cochlear prosthesis and speech processor. Three months postoperatively, these patients showed significantly better results with the cochlear prosthesis than for preoperative testing with a conventional hearing aid or vibrotactile aid (following a 6-month trial with the aid) on each of a series of tests from the Minimal Auditory Capabilities battery. Assessment of lipreading enhancement using standard speech tests, consonant recognition studies, and speech tracking showed significant improvements for each patient when using the cochlear prosthesis. Six patients showed a significant amount of open set speech discrimination without lipreading at levels which have not been reported for single electrode cochlear prostheses. The two patients who performed poorly on these tests both had restricted multiple channel systems due to their disease, one patient being restricted to virtually a single channel system and the other to only ten of the 22 electrodes. These results indicate that this multiple channel cochlear prosthesis has potential as a treatment for profound postlingual deafness over a wide range of etiologies and ages.
Your place or mine? A phylogenetic comparative analysis of marital residence in Indo-European and Austronesian societies

Accurate reconstruction of prehistoric social organization is important if we are to put together satisfactory multidisciplinary scenarios about, for example, the dispersal of human groups. Such considerations apply in the case of Indo-European and Austronesian, two large-scale language families that are thought to represent Neolithic expansions. Ancestral kinship patterns have mostly been inferred through reconstruction of kin terminologies in ancestral proto-languages using the linguistic comparative method, and through geographical or distributional arguments based on the comparative patterns of kin terms and ethnographic kinship ‘facts’. While these approaches are detailed and valuable, the processes through which conclusions have been drawn from the data fail to provide explicit criteria for systematic testing of alternative hypotheses. Here, we use language trees derived using phylogenetic tree-building techniques on Indo-European and Austronesian vocabulary data. With these trees, ethnographic data and Bayesian phylogenetic comparative methods, we statistically reconstruct past marital residence and infer rates of cultural change between different residence forms, showing Proto-Indo-European to be virilocal and Proto-Malayo-Polynesian uxorilocal. The instability of uxorilocality and the rare loss of virilocality once gained emerge as common features of both families.
Stochastic Geometry Modeling and Analysis of Multi-Tier Millimeter Wave Cellular Networks

In this paper, a new mathematical framework to the analysis of millimeter wave cellular networks is introduced. Its peculiarity lies in considering realistic path-loss and blockage models, which are derived from recently reported experimental data. The path-loss model accounts for different distributions of line-of-sight and non-line-of-sight propagation conditions and the blockage model includes an outage state that provides a better representation of the outage possibilities of millimeter wave communications. By modeling the locations of the base stations as points of a Poisson point process and by relying on a noise-limited approximation for typical millimeter wave network deployments, simple and exact integral as well as approximated and closed-form formulas for computing the coverage probability and the average rate are obtained. With the aid of Monte Carlo simulations, the noise-limited approximation is shown to be sufficiently accurate for typical network densities. The noise-limited approximation, however, may not be sufficiently accurate for ultra-dense network deployments and for sub-gigahertz transmission bandwidths. For these case studies, the analytical approach is generalized to take the other-cell interference into account at the cost of increasing its computational complexity. The proposed mathematical framework is applicable to cell association criteria based on the smallest path-loss and on the highest received power. It accounts for beamforming alignment errors and for multi-tier cellular network deployments. Numerical results confirm that sufficiently dense millimeter wave cellular networks are capable of outperforming micro wave cellular networks, in terms of coverage probability and average rate.
La mie de pain n'est pas une amie : une étude EEG sur la perception de différences infraphonémiques en situation de variations

Nous avons examine les correlats electrophysiologiques de la sensibilite des auditeurs aux indices acoustiques fins en condition de variabilite intra-locuteur dans le but de tester la pertinence de tels indices durant le traitement de la parole. Pour ce faire, une version modifiee du paradigme Oddball a ete utilisee avec pour stimuli des syllabes homophones telles que la et l'a et dans une seconde experience, des sequences plus longues telles que la mie et l'amie. Le principal resultat de cette etude a ete l'observation d'une negativite de discordance (MMN) pour les deviants homophones. Le systeme de perception de la parole est par consequent sensible aux differences intra-phonemiques entre des sequences homophones malgre le contexte de variabilite de la parole. Les indices acoustiques fins sont donc assez robustes pour pouvoir jouer un role dans le traitement de la parole.
mvHash-B - A New Approach for Similarity Preserving Hashing

The handling of hundreds of thousands of files is a major challenge in today's IT forensic investigations. In order to cope with this information overload, investigators use fingerprints (hash values) to identify known files automatically using blacklists or whitelists. Besides detecting exact duplicates it is helpful to locate similar files by using similarity preserving hashing (SPH), too. We present a new algorithm for similarity preserving hashing. It is based on the idea of majority voting in conjunction with run length encoding to compress the input data and uses Bloom filters to represent the fingerprint. It is therefore called mvHash-B. Our assessment shows that mvHash-B is superior to other SPHs with respect to run time efficiency: It is almost as fast as SHA-1 and thus faster than any other SPH algorithm. Additionally the hash value length is approximately 0.5% of the input length and hence outperforms most existing algorithms. Finally, we show that the robustness of mvHash-B against active manipulation is sufficient for practical purposes.
Perceptual model for non-intrusive speech quality assessment

In order to estimate the quality of degraded speech processed by communication networks, conventional objective speech quality assessment methods require the source speech signal, which has been applied to the networks, as well as the processed speech. The paper presents a new paradigm in objective speech quality assessment. In contrast to previous objective models, the proposed auditory non-intrusive quality estimation (ANIQUE) model estimates the quality of speech without using the source speech information. ANIQUE is a perceptual model which simulates the functional role of the human auditory system at both peripheral level and central auditory level. The performance of ANIQUE is demonstrated using 19 different subjective MOS databases.
Incorporating Memory Management into User-Level Network Interfaces

User-level network interfaces allow applications direct access to the network without operating system intervention on every send and receive. Messages are transferred directly to and from user-space by the network interface while observing the traditional protection boundaries between processes. Current user-level network interfaces limit this message transfer to a per-process region of permanently-pinned physical memory to allow safe DMA. This approach is inflexible in that it requires data to be copied into and out of this memory region, and does not scale to a large number of processes. This paper presents an extension to the U-Net user-level network architecture (U-Net/MM) allowing messages to be transferred directly to and from any part of an application''s address space. This is achieved by integrating a translation look-aside buffer into the network interface and coordinating its operation with the operating system''s virtual memory subsystem. This mechanism allows network buffer pages to be pinned and unpinned dynamically. Two implementations of U-Net/MM are described, demonstrating that existing commodity hardware and commercial operating systems can efficiently support the architecture.
On the Foundations of Expected Expected Utility

Intelligent agents often need to assess user utility functions in order to make decisions on their behalf, or predict their behavior. When uncertainty exists over the precise nature of this utility function, one can model this uncertainty using a distribution over utility functions. This view lies at the core of games with incomplete information and, more recently, several proposals for incremental preference elicitation. In such cases, decisions (or predicted behavior) are based on computing the expected expected utility (EEU) of decisions with respect to the distribution over utility functions. Unfortunately, decisions made under EEU are sensitive to the precise representation of the utility function. We examine the conditions under which EEU provides for sensible decisions by appeal to the foundational axioms of decision theory. We also discuss the impact these conditions have on the enterprise of preference elicitation more broadly.
Comparisons of GnRH Antagonist versus GnRH Agonist Protocol in Supposed Normal Ovarian Responders Undergoing IVF: A Systematic Review and Meta-Analysis

Objective To evaluate the effectiveness and safety of GnRH antagonist and GnRH agonist in supposed normal ovarian responders undergoing IVF. Methods Data from 6 databases were retrieved for this study. The RCTs of GnRH agonist and GnRH antagonist use during IVF-EF therapy for patients with supposed normal ovarian response were included. A meta-analysis was performed with Revman 5.1software. Results Twenty-three RCTs met the inclusion criteria. The number of stimulation days (mean difference (MD): −0.66, 95% confidence interval (CI): −1.04∼−0.27), Gn amount (MD: −2.92, 95% CI: −5.0∼−0.85), E2 values on the day of HCG (MD: −330.39, 95% CI: −510.51∼−150.26), Number of oocytes retrieved (MD: −1.33, 95% CI: −2.02∼−0.64), clinical pregnancy rate (odds ratio (OR): 0.87, 95% CI: 0.75−1.0), and ovarian hyperstimulation syndrome (OHSS) incidence (OR: 0.59, 95% CI: 0.42∼0.82) were significantly lower in GnRH antagonist protocol than GnRH agonist protocol. However, the endometrial thickness on the day of HCG (MD: −0.04, 95% CI: −0.23∼0.14), the ongoing pregnancy rate (OR: 0.87, 95% CI: 0.74∼1.03), live birth rate (OR: 0.89, 95% CI: 0.64∼1.24), miscarriage rate (OR: 1.17, 95% CI: 0.85∼1.61), and cycle cancellation rate (OR: 1.11, 95% CI: 0.90∼1.37) did not significantly differ between the 2 groups. Conclusions During IVF treatment for patients with supposed normal responses, the incidence of OHSS were significantly lower, whereas the ongoing pregnancy and live birth rates were similar in the GnRH antagonist compared with the standard long GnRH agonist protocols.
ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice.

BACKGROUND & AIMS ZBP-89 (also ZNF148 or Zfp148) is a butyrate-inducible zinc finger transcription factor that binds to GC-rich DNA elements. Deletion of the N-terminal domain is sufficient to increase mucosal susceptibility to chemical injury and inflammation. We investigated whether conditional deletion of ZBP-89 from the intestinal and colonic epithelium of mice increases their susceptibility to pathogens such as Salmonella typhimurium. METHODS We generated mice with a conditional null allele of Zfp148 (ZBP-89(FL/FL)) using homologous recombination to flank Zfp148 with LoxP sites (ZBP-89(FL/FL)), and then bred the resulting mice with those that express VillinCre. We used microarray analysis to compare gene expression patterns in colonic mucosa between ZBP-89(ΔInt) and C57BL/6 wild-type mice (controls). Mice were gavaged with 2 isogenic strains of S. typhimurium after administration of streptomycin. RESULTS Microarray analysis revealed that the colonic mucosa of ZBP-89(ΔInt) mice had reduced levels of tryptophan hydroxylase 1 (Tph1) messenger RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin (5-hydroxytryptamine [5HT]) biosynthesis. DNA affinity precipitation demonstrated direct binding of ZBP-89 to the mouse Tph1 promoter, which was required for its basal and butyrate-inducible expression. ZBP-89(ΔInt) mice did not increase mucosal levels of 5HT in response to S. typhimurium infection, and succumbed to the infection 2 days before control mice. The ΔhilA isogenic mutant of S. typhimurium lacks this butyrate-regulated locus and stimulated, rather than suppressed, expression of Tph1 approximately 50-fold in control, but not ZBP-89(ΔInt), mice, correlating with fecal levels of butyrate. CONCLUSIONS ZBP-89 is required for butyrate-induced expression of the Tph1 gene and subsequent production of 5HT in response to bacterial infection in mice. Reductions in epithelial ZBP-89 increase susceptibility to colitis and sepsis after infection with S. typhimurium, partly because of reduced induction of 5HT production in response to butyrate and decreased secretion of antimicrobial peptides.
Interventions and policies to enhance wellbeing

About the Editors ix Contributors xi Full Contents of Wellbeing: A Complete Reference Guide xiii Introduction to Wellbeing: A Complete Reference Guide xxvii Introduction to this Volume xxxv 1 The State of Wellbeing Science: Concepts, Measures, Interventions, and Policies 1 Felicia A. Huppert Part 1 Individual and Group Interventions across the Life Course 51 2 Parenting Interventions to Promote Wellbeing and Prevent Mental Disorder 53 Sarah Stewart-Brown 3 Promoting Mental Health and Wellbeing in Schools 93 Katherine Weare and Melanie Nind 4 An Exploration of the Effects of Mindfulness Training and Practice in Association with Enhanced Wellbeing for Children and Adolescents: Theory, Research, and Practice 141 Christine Burke 5 MindMatters: Implementing Mental Health Promotion in Secondary Schools in Australia 185 Louise Rowling and Trevor Hazell 6 A Systematic Review of Mental Health Promotion in the Workplace 221 Czeslaw Czabla and Katarzyna Charzynska 7 Wellbeing Begins with "We": The Physical and Mental Health Benefits of Interventions that Increase Social Closeness 277 Bethany E. Kok and Barbara L. Fredrickson 8 The Experience Corps: Intergenerational Interventions to Enhance Wellbeing Among Retired People 307 George W. Rebok, Michelle C. Carlson, Kevin D. Frick, Katherine D. Giuriceo, Tara L. Gruenewald, Sylvia McGill, Jeanine M. Parisi, William A. Romani, Teresa E. Seeman, Elizabeth K. Tanner, and Linda P. Fried 9 Enhancing Mental Health and Mental Wellbeing in Older People: Important Concepts and Effective Psychosocial Interventions 331 Anna K. Forsman, Eija Stengard, and Kristian Wahlbeck Part 2 Interventions to Create Positive Organizations and Communities 355 10 Wellbeing as a Business Priority: Experience from the Corporate World 357 Catherine Kilfedder and Paul Litchfield 11 The Power of Philanthropy and Volunteering 387 Sara Konrath 12 Community Change: The Complex Nature of Interventions to Promote Positive Connections 427 Sue Roffey and Jacqueline Barnes 13 The Health and Wellbeing Effects of Active Labor Market Programs 465 Adam P. Coutts, David Stuckler, and David J. Cann Part 3 The Policy Perspective 483 14 Creating Good Lives Through Computer Games 485 Daniel Johnson, Peta Wyeth, and Penny Sweetser 15 Retooling for Wellbeing: Media and the Public s Mental Health 511 Marten W. deVries 16 Policy and Wellbeing: The U.K. Government Perspective 541 David Halpern 17 Measuring what Matters 561 Juliet Michaelson, Charles Seaford, Saamah Abdallah, and Nic Marks 18 Mental Health and Wellbeing at the Top of the Global Agenda 599 Eva Jane-Llopis, Peter Anderson, and Helen Herrman 19 How can Subjective Wellbeing be Improved? 611 John F. Helliwell Index 633