Miracle-dz/UniFAR-FTUs huggingface dataset:
A Decimal Floating-Point Accurate Scalar Product Unit with a Parallel Fixed-Point Multiplier on a Virtex-5 FPGA

Decimal Floating Point operations are important for applications that cannot tolerate errors from conversions between binary and decimal formats, for instance, commercial, financial, and insurance applications. In this paper, we present a parallel decimal fixed-point multiplier designed to exploit the features of Virtex-5 FPGAs. Our multiplier is based on BCD recoding schemes, fast partial product generation, and a BCD-4221 carry save adder reduction tree. Pipeline stages can be added to target low latency. Furthermore, we extend the multiplier with an accurate scalar product unit for IEEE 754-2008 decimal64 data format in order to provide an important operation with least possible rounding error. Compared to a previously published work, in this paper, we improve the architecture of the accurate scalar product unit and migrate to Virtex-5 FPGAs. This decreases the fixed-point multiplier's latency by a factor of two and the accurate scalar product unit's latency even by a factor of five.
Regulation of the Endosomal SNARE Protein Syntaxin 7 by Colony-Stimulating Factor 1 in Macrophages

ABSTRACT Colony-stimulating factor 1 (CSF-1) is the main growth factor controlling the development of macrophages from myeloid progenitor cells. However, CSF-1 also regulates some of the key effector functions of macrophages (e.g., phagocytosis and cytokine secretion). The endosomal SNARE protein syntaxin 7 (Stx7) regulates vesicle trafficking events involved in phagocytosis and cytokine secretion. Therefore, we investigated the ability of CSF-1 to regulate Stx7. CSF-1 upregulated Stx7 expression in primary mouse macrophages; it also upregulated expression of its SNARE partners Vti1b and VAMP8 but not Stx8. Additionally, CSF-1 induced the rapid serine phosphorylation of Stx7 and enhanced its binding to Vti1b, Stx8, and VAMP8. Bioinformatics analysis and results from experiments with kinase inhibitors suggested the CSF-1-induced phosphorylation of Stx7 was mediated by protein kinase C and Akt in response to phosphatidylinositol 3-kinase activation. Based on mutagenesis studies, CSF-1 appeared to increase the binding of Stx7 to its SNARE partners by inducing the phosphorylation of serine residues in the Habc domain and/or “linker” region of Stx7. Thus, CSF-1 is a key regulator of Stx7 expression and function in macrophages. Furthermore, the effects of CSF-1 on Stx7 may provide a mechanism for the regulation of macrophage effector functions by CSF-1.
I Trust It, but I Don’t Know Why

Objective: This study is the first to examine the influence of implicit attitudes toward automation on users’ trust in automation. Background: Past empirical work has examined explicit (conscious) influences on user level of trust in automation but has not yet measured implicit influences. We examine concurrent effects of explicit propensity to trust machines and implicit attitudes toward automation on trust in an automated system. We examine differential impacts of each under varying automation performance conditions (clearly good, ambiguous, clearly poor). Method: Participants completed both a self-report measure of propensity to trust and an Implicit Association Test measuring implicit attitude toward automation, then performed an X-ray screening task. Automation performance was manipulated within-subjects by varying the number and obviousness of errors. Results: Explicit propensity to trust and implicit attitude toward automation did not significantly correlate. When the automation’s performance was ambiguous, implicit attitude significantly affected automation trust, and its relationship with propensity to trust was additive: Increments in either were related to increases in trust. When errors were obvious, a significant interaction between the implicit and explicit measures was found, with those high in both having higher trust. Conclusion: Implicit attitudes have important implications for automation trust. Application: Users may not be able to accurately report why they experience a given level of trust. To understand why users trust or fail to trust automation, measurements of implicit and explicit predictors may be necessary. Furthermore, implicit attitude toward automation might be used as a lever to effectively calibrate trust.
One-year outcome after decompressive surgery for massive nondominant hemispheric infarction.

OBJECTIVE Massive cerebral infarction is often accompanied by early death secondary to transtentorial herniation. We have tested the hypothesis that decompressive hemicraniectomy for massive nondominant cerebral infarction is lifesaving in a series of 14 patients presenting with right hemispheric infarction and clinical signs of uncal herniation and impending death. We have further analyzed, in prospective follow-up examinations, the levels of physical, psychiatric, and social disabilities in these patients. METHODS The methods used included retrospective analysis to determine rates of immediate mortality and morbidity after surgical intervention. Prospective follow-up data were obtained to determine the level of recovery in surviving patients after 1 year. Standardized measures of outcome to assess physical, psychiatric, and social recovery included the Barthel Index, Zung Depression Scale, and Reintegration to Normal Living Index. RESULTS With decompressive hemicraniectomy, we were able to prevent death secondary to transtentorial herniation in all cases; 11 patients experienced long-term survival after the procedure, and three deaths were related to non-neurological causes. We observed that 8 of the 11 surviving patients were at home, were functioning with minimal to moderate assistance, and had Barthel scores greater than 60. The remaining three patients were severely disabled. Seven of the 11 survivors were able to walk at 1 year after undergoing the procedure. Depression and failure to reintegrate socially were experienced by most patients. CONCLUSION This series confirms the lifesaving nature of hemicraniectomy in patients deteriorating because of cerebral edema after infarction. In patients younger than 50 years, recovery to a state of near-independence is possible.
Game theoretic approach to cognitive radio ad hoc networks

The cognitive radio is an opportunistic scheme for accessing unused spectral bands by unlicensed users. This allows unlicensed users to transmit data over licensed band not used by the primary user and increases spectral efficiency by utilizing the vacant frequency slots. The lack of central management restricts the ad hoc cognitive users to efficiently access the unlicensed channels. In this paper, we discuss methods for spectrum access to unlicensed users for the benefit of the entire network. We incorporate game theoretic techniques to overcome the short-coming of underutilized spectrum and maximize the payoffs of licensed/cognitive users. The spectrum allocation problem in cognitive radios is modeled as a potential game and we observe the behavior of ad hoc cognitive radio networks. The choice of player's strategy is contingent upon the composition of the potential function.
Dietary fat intake and risk of epithelial ovarian cancer.

BACKGROUND Evidence exists that dietary fat may be a contributory factor in the development of hormone-related cancers such as ovarian cancer. Previous studies have demonstrated significantly higher circulating-estrogen levels among nonvegetarian women than among vegetarian women; the increase correlated directly with consumption of saturated fat. However, the contribution that dietary fat plays in the development of hormone-related cancers remains unresolved. PURPOSE Our purpose was to evaluate whether saturated fat intake increases the risk of ovarian cancer development. METHODS Population-based sampling was used to acquire cases and controls over a 3-year period from the study area, which included the highly populated region surrounding the western end of Lake Ontario, Canada. From the Ontario Cancer Registry, all histologically confirmed, primary malignant or borderline malignant epithelial ovarian tumors first diagnosed from November 1989 through October 1992 among study-area residents aged 35-79 years were determined. In total, 631 eligible case subjects were identified, of whom 450 (71.3%) were interviewed concerning reproduction and diet; 564 randomly selected population control subjects were similarly interviewed. From the quantitative diet-history information, average daily intakes of macronutrients and micronutrients were calculated. Unconditional continuous logistic regression methods were used for analysis, with adjustment for age at interview, number of full-term pregnancies, years of oral contraceptive use, and total daily caloric intake. RESULTS Saturated fat consumption was associated with increasing risk of ovarian cancer (odds ratio [OR] = 1.20 for each 10 g/day of intake; 95% confidence interval [CI] = 1.03-1.40; one-sided P = .0082). No relationship was seen with intake of unsaturated fats. Egg consumption also appeared related to increased risk (OR = 1.42 for each 100 mg of egg cholesterol per day; 95% CI = 1.18-1.72; two-sided P = .0002), though this association may have resulted from disease-related changes in the dietary practices of case subjects prior to diagnosis. Consumption of vegetable fiber (but not fruit or cereal fiber) was associated with decreased risk (OR = 0.63 for each 10 g/day; 95% CI = 0.49-0.80; two-sided P = .0001). All three nutrients (saturated fat, egg cholesterol, and vegetable fiber) remained statistically significant when included in the same regression model. CONCLUSION Diet may contribute to risk of ovarian cancer development. IMPLICATION If confirmed in further studies, this association may allow women to appreciably lower their risk of ovarian cancer through dietary modifications: reducing the intake of saturated fats and eating more vegetables.
Structure of the C‐terminal domain of Saccharomyces cerevisiae Nup133, a component of the nuclear pore complex

Nuclear pore complexes (NPCs), responsible for the nucleo-cytoplasmic exchange of proteins and nucleic acids, are dynamic macromolecular assemblies forming an eight-fold symmetric co-axial ring structure. Yeast (Saccharomyces cerevisiae) NPCs are made up of at least 456 polypeptide chains of {approx}30 distinct sequences. Many of these components (nucleoporins, Nups) share similar structural motifs and form stable subcomplexes. We have determined a high-resolution crystal structure of the C-terminal domain of yeast Nup133 (ScNup133), a component of the heptameric Nup84 subcomplex. Expression tests yielded ScNup133(944-1157) that produced crystals diffracting to 1.9{angstrom} resolution. ScNup133(944-1157) adopts essentially an all {alpha}-helical fold, with a short two stranded {beta}-sheet at the C-terminus. The 11 {alpha}-helices of ScNup133(944-1157) form a compact fold. In contrast, the previously determined structure of human Nup133(934-1156) bound to a fragment of human Nup107 has its constituent {alpha}-helices are arranged in two globular blocks. These differences may reflect structural divergence among homologous nucleoporins.
The Simulation and Recent Results of the HARP Experiment

The HARP experiment was performed for a systematic and precise study of the hadron production by proton and pion beams of momenta between 1.5 and 15 GeV/c interacting with different targets. The details of HARP Geant4 Monte Carlo simulated detector response are discussed. The first results of the measurement of double differential hadronic cross sections are presented and the comparisons between the data and Geant4 model predictions are shown.
Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the Stockholm Myocardial Infarction with Normal Coronaries study

Myocardial infarction with angiographically normal coronary arteries (MINCA) is an important subtype of myocardial infarction; however, the prevalence, underlying pathophysiology, prognosis and optimal management of this condition are still largely unknown. Cardiovascular magnetic resonance (CMR) imaging has the potential to clarify the underlying pathology in patients with MINCA. The objective of this study was to investigate the diagnostic value of CMR imaging in this group of patients.
Using social connection information to improve opinion mining: Identifying negative sentiment about HPV vaccines on Twitter

The manner in which people preferentially interact with others like themselves suggests that information about social connections may be useful in the surveillance of opinions for public health purposes. We examined if social connection information from tweets about human papillomavirus (HPV) vaccines could be used to train classifiers that identify anti-vaccine opinions. From 42,533 tweets posted between October 2013 and March 2014, 2,098 were sampled at random and two investigators independently identified anti-vaccine opinions. Machine learning methods were used to train classifiers using the first three months of data, including content (8,261 text fragments) and social connections (10,758 relationships). Connection-based classifiers performed similarly to content-based classifiers on the first three months of training data, and performed more consistently than content-based classifiers on test data from the subsequent three months. The most accurate classifier achieved an accuracy of 88.6% on the test data set, and used only social connection features. Information about how people are connected, rather than what they write, may be useful for improving public health surveillance methods on Twitter.
Effects of psychotherapy in combination with pharmacotherapy, when compared to pharmacotherapy only on blood pressure, depression, and anxiety in female patients with hypertension

We investigated effects of metacognitive detached mindfulness therapy and stress management training on hypertension and symptoms of depression and anxiety, as compared to a control condition. A total of 45 female patients (mean age: M = 36.49 years) were randomly assigned to one of three conditions: metacognitive detached mindfulness therapy, stress management training, and the control condition. Blood pressure and symptoms of depression and anxiety decreased from baseline to post-test, to follow-up. Group comparisons showed that blood pressure and symptoms of depression and anxiety decreased more in psychotherapeutic groups than in the control group. Psychotherapeutic treatment of hypertension reduced blood pressure and symptoms of depression and anxiety. Positive effects were observable at follow-up 8 weeks later.
Temporal Logics for Communicating Sequential Agents: I

We introduce a class of distributed systems called Communicating Sequential Agents (CSAs). Sound and complete axiomatizations are provided for various subclasses using a family of indexed temporal logics. Some of the important features of these logics are: • Both the formulas and the structures for the logics reflect the fact that a system is composed out of a number of participating sequential agents. • Formulas of the logics are interpreted only at local states. • An agent makes a definite assertion about another agent only if it has received — directly or indirectly — some communication from that agent supporting that assertion.
An Analysis of Patient Falls and Fall Prevention Programs Across Academic Medical Centers

UHC conducted an analysis of more than 25 000 patient fall reports entered into the UHC Patient Safety Net incident reporting tool. Gaps were found in the completion of fall risk assessments, the ability of tools to accurately assess risk, and prevention strategies in particular inpatient units and emergency department. Common factors in falls resulting in major harm or death included age more than 80 years, altered mental status, ambulation (often without assistance), toileting, and diuretics and anticoagulants.
Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers.

To examine the role of development in the origin of evolutionary novelties, we investigated the developmental mechanisms involved in the formation of a complex morphological novelty-branched feathers. We demonstrate that the anterior-posterior expression polarity of Sonic hedgehog (Shh) and Bone morphogenetic protein 2 (Bmp2) in the primordia of feathers, avian scales, and alligator scales is conserved and phylogenetically primitive to archosaurian integumentary appendages. In feather development, derived patterns of Shh-Bmp2 signaling are associated with the development of evolutionarily novel feather structures. Longitudinal Shh-Bmp2 expression domains in the marginal plate epithelium between barb ridges provide a prepattern of the barbs and rachis. Thus, control of Shh-Bmp2 signaling is a fundamental component of the mechanism determining feather form (i.e., plumulaceous vs. pennaceous structure). We show that Shh signaling is necessary for the formation and proper differentiation of a barb ridge and that it is mediated by Bmp signaling. BMP signaling is necessary and sufficient to negatively regulate Shh expression within forming feather germs and this epistatic relationship is conserved in scale morphogenesis. Ectopic SHH and BMP2 signaling leads to opposing effects on proliferation and differentiation within the feather germ, suggesting that the integrative signaling between Shh and Bmp2 is a means to regulate controlled growth and differentiation of forming skin appendages. We conclude that Shh and Bmp signaling is necessary for the formation of barb ridges in feathers and that Shh and Bmp2 signaling constitutes a functionally conserved developmental signaling module in archosaur epidermal appendage development. We propose a model in which branched feather form evolved by repeated, evolutionary re-utilization of a Shh-Bmp2 signaling module in new developmental contexts. Feather animation Quicktime movies can be viewed at http://fallon.anatomy. wisc.edu/feather.html.
Kinetic-potentiometric determination of monosodium glutamate in soups and soup bases and of glutamic dehydrogenase.

A simple and selective procedure has been developed for the determination of glutamic acid and glutamic dehydrogenase by using an ammonia gas-sensing electrode. Glutamic acid is deaminated by bacterial glutamic dehydrogenase in the presence of β-NAD+. A linear relationship exists between the initial rate of ammonia release and the substrate concentration or the enzyme activity. Optimum conditions for the determinations were established. Glutamic acid in the range 1.0 × 10–4–1.0 × 10–3M and enzyme in the range 0.0500–0.750 U can be determined with relative errors of about 2%. A method is given for determining monosodium glutamate in soups and soup bases. The method was compared with the official AOAC method; satisfactory agreement was achieved.
Efficacy and In Vitro Cytotoxicity of Nanostructured Lipid Carriers for Paclitaxel Delivery

Paclitaxel (PTX) is an anticancer drug having poor aqueous solubility and low bioavailability. Formulation of PTX into Nanostructure lipid carriers (NLC) could be a potential way to enhance PTX aqueous solubility and bioavailability hence increases efficacy and decreases side effects. Eight PTX-NLC formulae were prepared using homogenization-ultrasonication technique. Characterization of the nanoparticles was done by transmission electron microscopy and by measurement of particle size, poly dispersibility index and zeta potential. Encapsulation efficiency, drug loading, and in vitro release were measured. Particle size ranged between 172.8 ± 0.8 to 378.2 ± 1.8 nm and zeta potential between -18.6 ± 0.4 to -28.1 ± 1.2 mV. High EE and DL were obtained due to incorporation of liquid lipid and the in vitro release showed prolonged time dependent release compared to Taxol®. NLC-3 had the best results among the eight prepared formulae. In vitro cytotoxicity of NLC-3 was evaluated on MCF-7 cell line and compared to pure PTX powder and Taxol®. These findings show that NLC is a potential carrier to improve efficacy and enhance PTX delivery.
Necrotic enteritis in broiler chickens. III. Reproduction of the disease.

Lesions typical of necrotic enteritis could be produced experimentally in from 11-26% of broiler chickens consuming feed containing approximately 10(7) Clostridium perfringens per gram. Highest mortality was produced using isolates from field cases of necrotic enteritis which were reisolated from experimental cases in the laboratory. Penicillin in the drinking water at 100,000 I.U. /litre completely prevented mortality whereas chloramphenicol at 110 mg/litre delayed the onset and reduced the number of deaths compared to controls.
Test and analysis of MR mounting system for automotive engines

Vibration of the automotive engine has the characteristics of wide frequency band, multi-vibration sources and multi-main frequencies. Limited capability of passive mounting systems can be provided for engine vibration isolation. A MR semiactive mounting system for automotive engines is investigated in this paper. The dynamic model of the vertical vibration isolation system for the engine and an efficient damping control model of the MR mount are established. The frequency characteristics of the engine vibration are analyzed. The fuzzy control algorithm for the MR mounting system is designed, and the isolation performance of the MR mounting system is analyzed based on the developed experimental setup in Hefei University of Technology.
Preoperative ultrasound monitoring can reduce postoperative bladder distension: A randomized study

Abstract Objective. The aim of this study was to explore whether close preoperative ultrasound monitoring starting in the emergency room (ER) could prevent postoperative bladder distension among acute orthopaedic patients. Material and methods. A randomized controlled trial was conducted at a 650-bed level-2 centre in Sweden. Inclusion criteria were admittance via ER to an orthopaedic ward for acute surgery. Bladder volumes were measured with a portable ultrasound scanner (Bladderscan BVI 3000). In the intervention group, all patients were scanned in the ER and then regularly at the ward at predefined times until surgery. In the control group, no regular scanning was performed before surgery. During surgery, the same procedure was performed for both groups: bladder scanning immediately after arrival to the recovery room and continuous postoperative scanning until voiding. The primary outcome was postoperative bladder distension, defined as a bladder volume ≥500 ml. Secondary outcomes were postoperative urinary tract infection and hospital length of stay. Results. A total of 281 patients completed the study, 141 in the intervention group and 140 in the control group. Postoperative bladder distension was significantly higher in the control group (27.1% vs 17.0%; p = 0.045, 95% confidence interval 4.9–19.8) in the intention-to-treat, per-protocol and as-treated analyses. No statistical difference was found between the intervention group and the control group regarding the secondary outcomes. Conclusions. Frequent bladder monitoring starting in the ER can reduce postoperative bladder distension among acute orthopaedic patients. A preoperative bladder monitoring protocol should be implemented early in the ER for all patients admitted for acute orthopaedic procedures.