Miracle-dz/UniFAR-FTUs huggingface dataset:
Hu23F2G, an Antibody Recognizing the Leukocyte CD11/CD18 Integrin, Reduces Injury in a Rabbit Model of Transient Focal Cerebral Ischemia

Neutrophils are known to mediate injury in acute ischemic stroke especially during reperfusion. Migration of neutrophils into regions of ischemic injury involves binding to the endothelial cell's intercellular adhesion molecule (ICAM-1) through the leukocyte integrin, CD11/CD18. We studied the potential for neuroprotection with a humanized antibody that binds to and blocks the functions of the CD11/CD18 integrin in a rabbit model of transient focal ischemia. Fifteen New Zealand White rabbits underwent transorbital occlusion of the left middle cerebral, anterior cerebral, and internal carotid arteries using aneurysm clips for 2 h, followed by 6 h of reperfusion. Treatment with a maximally saturating dose (4 mg/kg) of a humanized CD11/CD18 monoclonal antibody (Hu23F2G, ICOS Corp., Bothell, WA) (n = 8) or placebo (n = 7) was administered 20 min after occlusion and given as a single intravenous bolus. Hemispheric ischemic neuronal damage (IND) as seen on hematoxylin- and eosin-stained sections was significantly reduced in Hu23F2G-treated animals by 57% (Hu23F2G: 15 +/- 6.9%; placebo: 35 +/- 5%; mean +/- SEM, P < 0.05, t-test). Immunohistochemical staining with neutrophil elastase confirmed the presence of neutrophils within regions of IND in control brains. Treatment with Hu23F2G resulted in marked reduction of neutrophil infiltration. (No. of neutrophils/IND area: Hu23F2G 36.1 +/- 36.7 cm-2, placebo 460.6 +/- 101.8 cm-2, P = 0.001. ) Antagonism of neutrophil migration at the level of the CD11/CD18 integrin reduces ischemic injury in experimental stroke.
Realistic view synthesis of a structured traffic environment via adversarial training

Generating a realistic image from a novel viewpoint has always been a key problem in image-based rendering and other related domains. In this paper we utilize the state-of-the-art generative adversarial networks(GAN) to synthesize novel views of a structured scene. Based on our proposed representations for traffic scene, a realistic image of a certain viewpoint can be generated via conditional GANs, given the geometric layout of the corresponding position and pose. In order to preserve the geometric property of the input in the generated image, we propose a simple but effective constraint in the generator network. Qualitative and comparative results have validated our method as well as shown its effectiveness and efficiency.
Identification of Sybil Attack on Social Networks

- Social networks play a vital role in daily life since it is vulnerable to many security attacks, namely Sybil attacks. The Sybil attack is an attack where a single user can create a many bogus identity to impersonate like others. The Sybil node in social networking is used for criminal activities such as stealing legitimate information about the user present in social networks it will lead to system degradation process. Since the Sybil identification algorithm does not provide a complete solution to detect the Sybil node in social networks. In order to overcome these drawbacks Sybil defender algorithm gets deployed in a proposed framework to detect the Sybil node in social networks. The Sybil defender algorithm will perform a limited number of random walk on social networks. Sybil defender is a combination of both Sybil identification algorithm and Sybil community detection algorithm. A Sybil identification algorithm is used to detect the Sybil node and Sybil community detection algorithm is used to detect Sybil community around the Sybil node in the social networks. By comparing with the existing approaches Sybil node will be effectively detected using Sybil defender algorithm. This proposed and existing works are measured in terms of evaluation metrics namely non-trustworthy rate, detection rate, packet loss, end to end delivery.
trans-3,3′,4,5′-Tetramethoxystilbene

The title compound, C18H20O4, was synthesized by a Wittig–Horner reaction of diethyl 3,4-dimethoxybenzylphosphate and 3,5-dimethoxybenzaldehyde. In the crystal, the dihedral angle between the two aromatic rings is 2.47 (12)°. All the methoxy groups are almost coplanar with the aromatic ring to which they are attached [C—C—O—C torsion angles = −2.8 (3), −5.2 (4), −176.3 (2) and −178.0 (2)°].
Genotyping of Acanthamoeba Isolated From Surface and Stagnant Waters of Qazvin, Central Iran

1 Department of Parasitology, School of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran2 Department of Parasitology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran3 Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran
Comparison of Short- and Long-term Results of Drug-Eluting vs. Bare Metal Stenting in the Porcine Internal Carotid Artery

Purpose To evaluate the development of neointimal hyperplasia after implantation of drug-eluting stents (paclitaxel) compared to bare metal stents in porcine internal carotid arteries (ICAs). Methods While drug-eluting stents have effectively reduced neointimal proliferation in porcine external carotid arteries, the porcine internal carotid artery (ICA) is more sensitive to shear stress and altered flow conditions. Thus, a study was conducted to evaluate bare vs. drug-eluting stents in porcine ICAs. Under general anesthesia, 18 domestic pigs were implanted with paclitaxel-eluting (n=18) and bare (n=18) stents in the left and right ICAs, respectively. After 1 and 3 months, control carotid angiography was performed, followed by histopathological and histomorphometric analyses of the stented ICA. Results Histopathological results (fibrin deposition, necrosis, inflammation) were similar in the groups at 1 and 3 months. Moreover, the injury score and rate of endothelialization did not differ between the groups. Histomorphometric analysis after 1 month revealed significantly (p<0.05) less neointimal hyperplasia after implantation of paclitaxel-eluting stents. The antiproliferative effect of paclitaxel-eluting stents were maintained during the 3-month follow-up: the neointimal area was 0.7±0.5 vs. 1.2±0.6 mm2 (p<0.01), the area stenosis was 23.5%±13.9% vs. 37.8%±14.4% (p<0.01), the maximal neointimal thickness was 0.2±0.1 vs. 0.2±0.9 mm (p<0.05) in paclitaxel-eluting vs. bare stents, respectively. Implantation of paclitaxel-eluting and bare stents did not lead to edge restenosis or vessel remodeling in porcine ICAs at 1 or 3 months. Conclusion Compared to bare metal stents, drug-eluting stents implanted in the porcine ICA produced significantly less neointimal hyperplasia.
Association between diabetes mellitus and the occurrence and outcome of intracerebral hemorrhage

Objective: Whether diabetes mellitus (DM) is a risk factor for spontaneous intracerebral hemorrhage (ICH) and influences outcome after ICH remains unclear. Methods: One reviewer searched Ovid MEDLINE and Embase 1980–2014 inclusive for studies investigating the associations between DM and ICH occurrence or DM and ICH case fatality. Two reviewers independently confirmed each study's eligibility, assessed risk of bias, and extracted data. One reviewer combined studies using random effects meta-analysis. Results: Nineteen case-control studies involving 3,397 people with ICH and 5,747 people without ICH found an association between DM and ICH occurrence (unadjusted odds ratio [OR] 1.23, 95% confidence interval [CI] 1.04–1.45; I2 = 22%), which did not differ between 17 hospital-based and 2 population-based studies (pdiff = 0.70), and was similar in the 16 studies that controlled for age and sex (unadjusted OR 1.15, 95% CI 0.95–1.40; I2 = 14%). This association was not identified in 3 population-based cohort studies in which ICH occurred in 38 (0.66%) of 5,724 people with DM and 448 (0.57%) of 78,702 people without DM (unadjusted risk ratio [RR] 1.27, 95% CI 0.68–2.36; I2 = 69%). DM was associated with a higher case fatality by 30 days or hospital discharge in 18 cohort studies involving 813 people with DM and 3,714 people without DM (unadjusted RR 1.52, 95% CI 1.28–1.81; I2 = 49%). Conclusions: The findings suggest that there may be modest associations between DM and ICH occurrence and outcome, but further information from large, population-based studies that account for confounding is required before the association can be confirmed.
Current and potential pharmacological treatments for obsessive-compulsive disorder

In the past 20 years, several effective treatments have been developed for obsessive-compulsive disorder. Despite this, it is a disorder that is often inadequately treated by available therapies. Recent advances in neuroimaging and neurophysiology have provided some clues to possible treatments that may be more effective in treating this disorder. Serotonin agents remain the cornerstone of pharmacological treatment for obsessive-compulsive disorder. The development of agents that target specific serotonin receptor subtypes may improve the effectiveness of drug treatment. Other possible future treatment approaches are also discussed.
MULTI RESPONSE OPTIMIZATION OF MACHINING PARAMETERS IN HIGH SPEED MACHINING OF Y-ZTA INSERT USING DESIRABILITY FUNCTION APPROACH OF RESPONSE SURFACE METHODOLOGY (RSM)

An attempt has been made to apply the multi response optimization using desirability function concept for optimizing the cutting conditions (cutting speed, feed rate and depth of cut) on machining responses i.e. flank wear, cutting force, surface roughness and chip reduction coefficient while finish turning of AISI 4340 steel using developed yttria based Zirconia Toughened Alumina (ZTA) inserts. These ZTA inserts were prepared through wet chemical co precipitation route followed by powder metallurgy process. The machining performance of the insert has been evaluated using NH 26 lathe installed in the laboratory with different condition as per Central Composite Design of Response Surface Methodology. The mathematical models for each response have been developed using second order regression analysis. Key parameters and their interactive effect on each response have also been presented in graphical contours. The optimization of parameters has been done for machining with this non conventional cutting inserts using the desirability function concept with a target of high cutting speed and high feed rate. The aim is to minimize the responses i.e. flank wear, cutting force, surface roughness and chip reduction coefficient. Using the criteria, the optimum condition has been arrived with a cutting speed of 380 m/min, feed rate of 0.24 mm/rev and depth of cut of 0.5 mm. Using the same cutting speed and feed condition, the desirability function values of flank wear, cutting force, surface roughness and chip reduction coefficient comes around 71%, 90%, 95% and 93%.
Power Efficient Clustering for Wireless Multimedia Sensor Network

The availability of inexpensive hardware such as CMOS cameras and microphones has fostered the development of wireless multimedia sensor networks (WMSNs). In WMSNs, wirelessly interconnected devices enable ubiquitously retrieving multimedia contents such as video and audio streams, and still images along with scalar data from surroundings for wide range of applications are constrained by processing, memory, and power resources. Image compression via low-complexity and resource efficient transforms has been addressed by several researchers to prolong network lifetime where energy conservation is achieved through sharing computational load among sensor nodes and by adjusting the transmission ranges of camera nodes. However, those schemes are not adaptive to the presence and changes of energy level of computational sensor nodes and to the amount of computational load. We propose a resource and energy efficient distributed image compression algorithm that dynamically configures according to the energy levels and the forwarding strategy that is based on the entropy of the image. The simulation results show that our adaptive distributed image compression scheme significantly prolongs the network lifetime and improves the network utilization efficiency, while maintaining adequate image quality.
Effect of latanoprost on the extracellular matrix of the ciliary muscle. A study on cultured cells and tissue sections.

Prostaglandin F2alpha and its analogue latanoprost, both prostanoid FP receptor agonists, reduce the intraocular pressure mainly by enhancing uveoscleral outflow. Changes in the extracellular matrix of the ciliary muscle may be involved in the increased outflow. The effect of latanoprost and prostaglandin F2alpha on the extracellular matrix of the ciliary muscle was investigated. Cell cultures of human ciliary muscle were treated with latanoprost acid or prostaglandin F2alpha for 1-2 days and were immunostained against various extracellular matrix components and metalloproteinases. Proteinases were also analysed by zymography and by measuring plasmin generating ability. For comparison, matrix components were immunolocalized on tissue sections from monkey eyes, treated topically once daily with latanoprost for 10 days. In response to both prostaglandins collagens I, III, and IV, fibronectin, laminin and hyaluronan were reduced, while metalloproteinase -2 and -3 were increased. Zymography demonstrated the presence of functionally active metalloproteinase -2. Both prostaglandins enhanced the generation of plasmin, an activator of metalloproteinases. In the anterior part of the ciliary muscle in latanoprost-treated eyes immunostained collagen VI was decreased in 5 out of 5 monkeys and collagen IV was decreased in 4 of the 5 monkeys. These results suggest a role for latanoprost in the remodeling of extracellular matrix in the ciliary muscle. A latanoprost-induced change in the extracellular matrix might augment the flow of aqueous humour through the ciliary muscle bundles of the uveoscleral pathway.
Ewolucja języka - współczesne kontrowersje

1. Wstep Ewolucje jezyka – rozumianą jako dziedzina badan – mozna zdefiniowac jako interdyscyplinarną nauke o filogenetycznym wylonieniu sie wlaściwej jedynie ludziom i uwarunkowanej genetycznie zdolności do nabycia jezyka naturalnego. O rozwoju jezyka mozemy mowic w trzech roznych – choc wzajemnie zaleznych – wymiarach, z ktorych kazdy wiąze sie z inną skalą czasową; są nimi: ontogeneza, glottogeneza oraz filogeneza (np. Kirby i Hurford 2001). Do niedawna jedynie pierwszy z nich uwazany byl za pelnoprawny obiekt badan naukowych, dwa pozostale zaś domene mitologii, religii i filozofii (zob. np. Fisiak 1985).
An Optimized Control Technique of Cascaded H-bridge Multilevel Active Front-ends

The paper is devoted to the investigation of a three-phase multilevel H-bridge PWM-Rectifier operating as a first stage of a back-to-back converter in high-power ac drives. First, a predictive control technique is described with reference to a 5-level converter. Starting from properly defined reference values, the algorithm pointed out allows the direct evaluation of the duty-cycles of all the voltage vectors involved in the VSR modulation. By means of the evaluated switching functions, at the end of every sampling interval the line-currents assume values practically equal to the imposed ones. Some unrestrictive hypotheses are introduced in order to efficaciously simplify the analytical expressions. As a second step, in the paper a specially designed modulation technique is shown. In addition to low values of dc-link voltage oscillations and of line-current distortion in steady-state operations together with high values of the power-factor, this modulation technique allows to keep balanced the different capacitor voltages, by properly using the intrinsic redundancy of the converter topology. Numerical results are presented with reference to some significant operative conditions in order to validate the theoretical considerations.
The Physical Results of Nonsuicidal Self-Injury: The Meaning Behind the Scars

Abstract The psychological meaning of scars from nonsuicidal self-injury (NSSI) has been examined in case studies, but descriptive studies are needed to better understand the meaning of NSSI scars. College students with NSSI scars (n = 49) completed questionnaires concerning the interpretive meaning of their scars, emotions associated with their scars, and clinical symptoms. Levels of scar-related growth were positively correlated with interpersonal functions of NSSI (e.g., autonomy, self-care) and negatively correlated with likelihood of future self-injury, self-disgust, self-injury regret, and self-injury scar regret. Conversely, higher levels of scar-related shame were associated with higher likelihood of future self-injury, depressive and borderline personality disorder symptoms, self-disgust, NSSI scar-related regret, and intrapersonal functions of NSSI (e.g., marking distress, self-punishment). Individuals finding shame or guilt may be a more clinically severe group than those finding growth from their scars.
Evaluation of a two-part survey item to assess moderate physical activity: the Cross-Cultural Activity Participation Study.

PURPOSE This study evaluated a two-part survey item that assessed adherence to the national moderate physical activity (MPA) recommendation (>/=30 min/day on >/=5 days/week). METHODS Participants were African American (n = 137), Native American (n = 129), and Caucasian (n = 50) women >/= 40 years from South Carolina and New Mexico, who were participating in a study validating physical activity surveys. The survey item was compared with data obtained from MPA recorded in PA records (min/day), Caltrac accelerometers (Muscle Dynamics, Torrance, CA) (kcal/day), and pedometers (steps/day). RESULTS Approximately 64% of the participants reported meeting the MPA recommendation on the survey item. Adjusted analyses showed that those who reported meeting the recommendation were more active than those who reported not meeting the recommendation (109.2 vs. 83.9 min/day, 2171.2 vs. 2088.4 kcal/day, and 5795.7 vs. 4797.2 steps/day, respectively; all p < 0.0001). The types of activities recorded in the PA record did not differ by self-reported adherence to the MPA recommendation except for walking (25.2 vs. 14.0 min/day for those who reported meeting vs. not meeting the recommendation, respectively; p < 0.05). A higher proportion of those who reported meeting the recommendation also reported participating in conditioning activities compared with those who reported not meeting the recommendation (31% vs. 19%, respectively; p < 0.05). CONCLUSIONS The two-part survey item can reliably differentiate between higher and lower levels of activity. Those who perceive themselves as meeting the MPA recommendation are, on average, likely to have higher activity levels than those who perceive that they do not meet the recommendation.
Phonetics and Speaker Identification

At the present time, phoneticians are receiving more and more requests for advice and assistance from police and solicitors in connection with cases involving tape-recorded speech samples, often with the assumption on the part of the inquirers of the existence of 'voice prints'. Without entering into a lengthy discussion of all the issues involved, it must be placed on record that the relevant specialists, the acoustic phoneticians, in Great Britain and indeed most other countries are totally opposed to any such concept within their discipline. It is certainly true that the speech of every person is unique and individual, but it cannot be argued from that that any visual representation of the measurements of speech made by electronic devices can capture this individual character. At most one can express the belief that the further evolution of electronics may well bring about such a possibility. Speaker identification by the acoustic aspect of speech analysis, i.e. the measurement electronically of the physical characteristics of speech, is thus not possible. There then remains the auditory aspect of speech analysis, this being the description of the sounds of speech by means of the researcher's ear, expressed in terms of a set of conventional symbols or phonetic notation. The auditory phonetician's judgements are, of course, subjective, but against this must be set the very long and intensive training all professional phoneticians undergo and the fact that their conclusions, being framed in terms of widely accepted conventions, can be examined critically by other phoneticians. Defence counsel have been known to complain of the subjec-
Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial.

OBJECTIVE The opiate antagonist drug naltrexone has been shown in a few studies with limited sample sizes to be effective when combined with psychosocial therapies for the treatment of alcohol dependence. The goal of this study was to obtain additional information regarding its efficacy in pertinent alcoholic populations and with a well-defined therapy. METHOD In this study, 131 recently abstinent alcohol-dependent outpatients were treated with 12 weekly sessions of manual-guided cognitive behavioral therapy and either 50 mg/day of naltrexone (N = 68) or placebo (N = 63) (with riboflavin added as a marker of compliance) in a double-blind, randomized clinical trial. Alcohol consumption, craving, adverse events, and urinary riboflavin levels were assessed weekly. Levels of blood markers of alcohol abuse were also ascertained during the trial. RESULTS The study completion, therapy participation, and medication compliance rates in the trial were high, with no differences between treatment groups. Naltrexone-treated subjects drank less, took longer to relapse, and had more time between relapses. They also exhibited more resistance to and control over alcohol-related thoughts and urges, as measured by a subscale of the Obsessive Compulsive Drinking Scale. Over the study period, 62% of the naltrexone group did not relapse into heavy drinking, in comparison with 40% of the placebo group. CONCLUSIONS Motivated individuals with moderate alcohol dependence can be treated with greater effectiveness when naltrexone is used in conjunction with weekly outpatient cognitive behavioral therapy. Naltrexone increases control over alcohol urges and improves cognitive resistance to thoughts about drinking. Thus, the therapeutic effects of cognitive behavioral therapy and naltrexone may be synergistic.
Effectiveness of a Guided Self-help Manual in Strengthening Resilience in People Diagnosed with Moderate Depression and Their Family Caregivers in Thailand: A Randomised Controlled Trial

ABSTRACT The growing incidence of depression in developing countries, such as Thailand, is placing increasing pressure on public mental health services, and those living in rural areas have limited access to these services. Resilience is integral to the recovery of people with depression and to caregivers. This parallel-group randomised controlled trial evaluated the effectiveness of a guided self-help manual in improving resilience in adults diagnosed with moderate depression and their primary caregivers in Thailand. Our findings provide preliminary evidence that the approach is an effective way of increasing resilience in adults with depression and their caregivers.