Miracle-dz/UniFAR-FTUs huggingface dataset:
CATCHR and HOPS-CORVET tethering complexes share a similar architecture

We show that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that the HOPS complex, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, suggesting that multisubunit tethering complexes use related structural frameworks.
A Validation Study of Korean Albany Panic and Phobia Questionnaire(APPQ)

Objectives：The Albany Panic and Phobia Questionnaire (APPQ) was developed to assess fear of activities that may elicit physical sensation in panic patients. There are three subscales (Agoraphobia, Social phobia, and Interoceptive fear) in the scale. The present study was conducted to determine the validity and reliability of APPQ in Korean population. Methods：One hundred thirty five panic patients and 135 community samples and were enrolled in this study. All subjects completed a psychometric assessment package which included APPQ, ASI-R, ACQ, BSQ, BAI, BDI. Results：1) APPQ showed good internal consistency (Cronbach’s α=.95) and high test-retest reliabilities (r=.77). 2) APPQ showed moderate correlations with ASI-R (r=.67), ACQ (r=.67), BSQ (r=.59) and BAI (r=.64). 3) An exploratory factor analysis revealed 3 factors (Agoraphobia, Social Phobia and Intorceptive fear). 4) Panic patients (with or without agoraphobia) had significantly higher sores of the APPQ interoceptive subscale than the community samples (F(2,27)=24.27, p
Sotalol vs metoprolol for ventricular rate control in patients with chronic atrial fibrillation who have undergone digitalization: a single-blinded crossover study.

AIMS To compare the effects of sotalol and metoprolol on heart rate, during isotonic (ITE) and isometric (IME) exercise and daily activities, in digitalized patients with chronic atrial fibrillation. METHODS AND RESULTS The study had a randomized, single-blinded, crossover design. Twenty-three patients with chronic atrial fibrillation received placebo for 4 weeks, followed by a 4-week period of treatment with sotalol and metoprolol in random order. At the end of each period, the patients were assessed with 24-h ECG monitoring, a cardiopulmonary exercise test and a handgrip manoeuvre. Both agents produced a lower heart rate than placebo at rest and at all levels of isotonic exercise (P < 0.001) without affecting oxygen uptake. Sotalol produced a lower heart rate than metoprolol only at submaximal exercise (116 +/- 9 bpm for sotalol vs 125 +/- 11 bpm for metoprolol, P < 0.001). During isometric exercise, sotalol produced a lower maximum heart rate than did metoprolol (113 +/- 22 vs 129 +/- 18 bpm, respectively). Both agents produced a lower mean heart rate than placebo over 24 h (P < 0.001 for all), while sotalol produced a lower mean heart rate than metoprolol during the daytime (P < 0.01). CONCLUSION Sotalol is a safe and effective agent for control of heart rate in digitalized patients with atrial fibrillation. Sotalol is superior to metoprolol at submaximal exercise, resulting in better rate control during daily activities.
The volatile anaesthetic sevoflurane attenuates lipopolysaccharide‐induced injury in alveolar macrophages

Acute lung injury (ALI) is a well‐defined inflammation whereby alveolar macrophages play a crucial role as effector cells. As shown previously in numerous experimental approaches, volatile anaesthetics might reduce the degree of injury in pre‐ or post‐conditioning set‐ups. Therefore, we were interested to evaluate the effect of the application of the volatile anaesthetic sevoflurane on alveolar macrophages regarding the expression of inflammatory mediators upon lipopolysaccharide (LPS) stimulation in vitro. Alveolar macrophages were stimulated with LPS. Two hours later, cells were exposed additionally to air (control) or to sevoflurane‐containing air for 4, 6, 8, 12 or 24 h. Tumour necrosis factor (TNF)‐α, cytokine‐induced neutrophil chemoattractant‐1 (CINC‐1), macrophage‐inflammatory protein‐2 (MIP‐2) and monocyte chemoattractant protein‐1 (MCP‐1) proteins were determined and chemotaxis assays were performed. To evaluate possible cellular signalling pathways phosphorylation of the kinases extracellular‐regulated kinase (ERK) and Akt was assessed. In the early phase of sevoflurane post‐conditioning expression of TNF‐α, CINC‐1, MIP‐2 and MCP‐1 was attenuated, leading to a diminished chemotaxis reaction for neutrophils. Phosphorylation of ERK seems to be a possible cellular mechanism in the sevoflurane‐induced protection in vitro. Pharmacological post‐conditioning of alveolar macrophages with sevoflurane immunmodulates the inflammatory response upon stimulation with endotoxin. This might be a possible option for a therapeutical approach in ALI.
Understanding and Surpassing Dropbox: Efficient Incremental Synchronization in Cloud Storage Services

Cloud storage services allow files to be synchronized among multiple users or devices easily. To minimize the amount of network traffic, these services utilize incremental data synchronization techniques. However, little is known about their particular mechanisms and corresponding efficiency. In this paper, we focus on Dropbox, the most popular cloud storage service, as a case study. We examine the bandwidth consumption on the Dropbox client under typical synchronization scenarios, and find that Dropbox wastes a lot of traffic due to matching unrelated chunks to compute incremental changes. More seriously, when file conflicts among clients, Dropbox directly downloads the whole file instead of the incremental changes. To solve these problems, we design and implement an efficient incremental synchronization system named Minbox. MinBox employs an efficient locality-sensitive hash for better similar chunk matching. Moreover, Minbox could forward the incremental changes during confliction by maintaining the relation of conflicting files. In comparison with Dropbox, Minbox significantly reduces network traffic and resolves file conflict with little overhead.
Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum

CHIP28 is a 28-kD hydrophobic integral membrane protein that functions as a water channel in erythrocytes and renal tubule epithelial cell membranes. We examined the transmembrane topology of CHIP28 in the ER by engineering a reporter of translocation (derived from bovine prolactin) into nine sequential sites in the CHIP28 coding region. The resulting chimeras were expressed in Xenopus oocytes, and the topology of the reporter with respect to the ER membrane was determined by protease sensitivity. We found that although hydropathy analysis predicted up to seven potential transmembrane regions, CHIP28 spanned the membrane only four times. Two putative transmembrane helices, residues 52-68 and 143-157, reside on the lumenal and cytosolic surfaces of the ER membrane, respectively. Topology derived from these chimeric proteins was supported by cell-free translation of five truncated CHIP28 cDNAs, by N-linked glycosylation at an engineered consensus site in native CHIP28 (residue His69), and by epitope tagging of the CHIP28 amino terminus. Defined protein chimeras were used to identify internal sequences that direct events of CHIP28 topogenesis. A signal sequence located within the first 52 residues initiated nascent chain translocation into the ER lumen. A stop transfer sequence located in the hydrophobic region from residues 90-120 terminated ongoing translocation. A second internal signal sequence, residues 155-186, reinitiated translocation of a COOH-terminal domain (residues 186-210) into the ER lumen. Integration of the nascent chain into the ER membrane occurred after synthesis of 107 residues and required the presence of two membrane-spanning regions. From this data, we propose a structural model for CHIP28 at the ER membrane in which four membrane- spanning alpha-helices form a central aqueous channel through the lipid bilayer and create a pathway for water transport.
Asymptotic Positivity of Hurwitz Product Traces

Consider the polynomial $tr (A + tB)^m$ in $t$ for positive hermitian matrices $A$ and $B$ with $m \in \N$. The Bessis-Moussa-Villani conjecture (in the equivalent form of Lieb and Seiringer) states that this polynomial has nonnegative coefficients only. We prove that they are at least asymptotically positive, for the nontrivial case of $AB \neq 0$. More precisely, we show that the $k$-th coefficient is positive for all integer $m \geq m_0$, where $m_0$ depends on $A$, $B$ and $k$.
Link Prediction via Convex Nonnegative Matrix Factorization on Multiscale Blocks

Low rank matrices approximations have been used in link prediction for networks, which are usually global optimal methods and lack of using the local information. The block structure is a significant local feature of matrices: entities in the same block have similar values, which implies that links are more likely to be found within dense blocks. We use this insight to give a probabilistic latent variable model for finding missing links by convex nonnegative matrix factorization with block detection. The experiments show that this method gives better prediction accuracy than original method alone. Different from the original low rank matrices approximations methods for link prediction, the sparseness of solutions is in accord with the sparse property for most real complex networks. Scaling to massive size network, we use the block information mapping matrices onto distributed architectures and give a divide-and-conquer prediction method. The experiments show that it gives better results than common neighbors method when the networks have a large number of missing links.
Chapter 12 The Amboseli Baboon Research Project : 40 Years of Continuity and Change

In 1963, Jeanne and Stuart Altmann traveled through Kenya and Tanzania searching for a baboon study site. They settled on the Maasai-Amboseli Game Reserve (later Amboseli National Park) and conducted a 13-month study that laid the groundwork for much future research. They returned for a short visit in 1969, and came again in July 1971 to establish a research project that has persisted for four decades. In July 1984 Susan Alberts joined the field team, later becoming a graduate student and eventually a director. Over the years, we have tackled research questions ranging from feeding ecology to behavioral endocrinology, from kin recognition to sexual selection, and from aging research to functional genetics. A number of our results have explicitly depended upon the longitudinal nature of the research. Without decades worth of individual-based data we would not have known, for instance, that the presence of fathers influenced the maturation rates of their offspring, that maternal dominance rank had pervasive effects on the physiology of sons, or that the social behavior of a female influenced her infants’ survival. Here we summarize the major research themes that have characterized each of the past four decades, and our directions for the future, emphasizing the scientific insights that the longitudinal nature of the study has made possible. S.C. Alberts Department of Biology, Duke University, Durham, NC, USA e-mail: alberts@duke.edu J. Altmann (*) Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA e-mail: altj@princeton.edu P.M. Kappeler and D.P. Watts (eds.), Long-Term Field Studies of Primates, DOI 10.1007/978-3-642-22514-7_12, # Springer-Verlag Berlin Heidelberg 2012 261
Intelligent Wearable Assistance System for Communicating with Interactive Electronic Media

The wearable computer that can understand the context of human life and communicate autonomously with various electronic media in a ubiquitous computing environment would be very useful as an assistant for humans. In this paper, we present a wearable computer that interacts with both humans and electronic media. The developed wearable computer can sense the interactive electronic media that a user wants to use and also communicate with it. Utilizing these interaction capabilities, it intermediates between each media and the user and offers a friendlier interface to the user who wears this system. We also show some scenarios and applications of the development system.
Hope over fear: social work education towards 2025

ABSTRACT Prediction of possible futures is fraught with dangers. Neither the global economic crisis which erupted in 2008 nor the political earthquake which shook Scotland over the issue of independence during 2014 was foreseen by many commentators, if indeed any. Given these experiences, predicting where social work education might be in 2025 is a potentially hazardous enterprise. Nevertheless, the recent resurgence of interest in utopian thinking reflects a widely felt desire to go beyond ‘capitalist realism’ and to envisage different possibilities – a desire also reflected in political developments in Greece and Spain. This development is primarily in reaction to the dominance of another form of utopian (or dystopian) thinking: neo-liberalism, with its message that ‘there is no alternative’. In this paper, I will argue that that search for alternatives has important implications for social work and social work education. Following a discussion of the ways in which neo-liberalism has shaped the profession over two decades, the paper will identify current challenges to neo-liberal social work and social work education and more widely, to the politics of austerity. Drawing on examples from different countries, I will argue that this ‘new radicalism’ points the way to a more politically engaged social work education.
Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

Continuous exposure of many types of neurons in cell culture to elevated concentrations of K+ greatly enhances their survival. This effect has been reported to be mediated by a sustained rise of cytoplasmic free Ca2+ concentration caused by influx of Ca2+ through voltage-gated channels activated by K(+)-induced chronic depolarization. In this report we investigate the effects of elevated K+ on the programmed death that embryonic rat sympathetic neurons undergo in culture when deprived of NGF. Elevated K+ in the culture medium did not significantly prevent death of NGF-deprived cells until after the third day following plating of embryonic day 21 neurons. On the fifth day after plating, incrementally increasing K+ concentrations in the culture medium from 5 to 100 mM caused chronic depolarization of neurons and had a biphasic effect on survival of NGF-deprived cells. Enhanced survival was steeply related to membrane potential, increasing from no enhanced survival in cells held at potentials between -51 and - 34 mV to 90–100% of control survival at about -21 mV. At potentials positive to -21 mV, survival decreased. Associated with the chronic depolarization was a sustained rise of steady-state free Ca2+ concentration that showed a biphasic relationship to membrane potential roughly similar to that exhibited by survival. Steady-state Ca2+ concentration increased with increasingly lower membrane potentials to a peak at about -23 mV (to approximately 240 nM from approximately 40 nM at about -51 mV) and then decreased at more positive potentials. The elevation of intracellular Ca2+ was largely blocked by dihydropyridine and phenylalkylamine Ca2+ channel antagonists and was potentiated by a dihydropyridine Ca2+ channel agonist. Neither the rise of Ca2+, or survival was affected by the Ca2+ channel antagonist, omega-conotoxin. Therefore, the Ca2+ elevation was probably caused by Ca2+ influx through L-type, but not N-type, channels. Antagonists of L channels blocked both survival and the sustained increase of steady-state free Ca2+ at similar concentrations, suggesting that the relevant factor determining survival of depolarized cells was Ca2+ influx rather than some other effect of depolarization. Surprisingly, however, there was no clear correlation between the sustained rise of Ca2+ and survival. Some membrane potentials that induced similar increases of Ca2+ concentration produced widely different levels of survival. While chronic depolarization promoted survival of neurons in the absence of NGF, cells supported in this manner showed little growth as measured by neurite extension, total cellular protein, and mean somal diameter. (ABSTRACT TRUNCATED AT 400 WORDS)
Centralization and the success of ERP implementation

Centralization, which indicates distribution of decision-making power in organizations, is well-discussed in innovation literature as one of the influencing factors of innovation implementation. Motivated by a gap in enterprise resource planning (ERP) research, the purpose of this paper is to investigate the influence of centralization on the success of ERP implementation. ,Centralization is characterized twofold: policy-related centralization (PRC) and work-related centralization (WRC). ERP implementation success is captured in terms of user acceptance and the use of the ERP system. Using organizational innovation theory, six hypotheses relating centralization, ERP implementation success, and organization size are built and tested using data gathered from 51 Indian organizations that implemented ERP. The data are analyzed using partial least squares-structural equation modeling. ,User acceptance is significantly inhibited by PRC. WRC has a negative influence on use. The negative influence of PRC on acceptance is more pronounced in the case of larger organizations. On the whole, a decentralized set-up is favorable to ERP implementation success. ,The study highlights the impact of a centralized management structure on success of ERP implementation and in doing so, it demarcates the varied influence of two types of centralization. It contributes to the scarce research on ERP implementation using the strong theoretical basis of organizational innovation. The findings highlight the implications of centralization to the implementation outcomes, for organizations embarking upon ERP.
Supporting “nomadic awareness” and team working through visually augmenting broadcast communication

* Mike Scaife died suddenly and unexpectedly while we were revising the paper. His contribution to the research was instrumental. ABSTRACT Nomadic team working involves close-knit groups collaborating over a large geographical space performing time-critical tasks. We present an ethnographic study of the way a dispersed team of technicians coordinate their work, highlighting the phenomenon of extraneous ‘detective work’ – where much communication, via walkie-talkies, needs to take place when uncertainty arises in their work. We suggest one way of providing better nomadic awareness is to visually augment verbal communication. We describe a distributed system we designed and evaluated to enable dispersed users to re-represent salient verbal information on interconnected wireless handheld devices and a large fixed display, as simple dynamic visualizations. Our findings showed that users were able to keep in touch and carry out their tasks much more effectively.
Integrating Business Analytics Systems with the Enterprise Environment: an Evolutionary Process Perspective

Business analytics systems create value and provide competitive advantage for organisations. We argue that operational and dynamic business analytics capabilities can explain how value is created, sustained and renewed. We develop an evolutionary, process-oriented theoretical framework that describes how dynamic and operational business analytics capabilities interact over time to create value. We use the framework to explain how business analytics systems were integrated with the enterprise environment in a longitudinal case study of a large financial institution. A number of key factors for success with business analytics systems are identified.
NEUROBEHAVIOURAL RELATIONSHIPS AFTER THE ONSET OF PUBERTY

The behavioural and cognitive development were studied of 68 children with and 259 without minor neurological function (MND) at 14 years, when the majority of children showed three or more physical signs of puberty. MND was differentiated into fine manipulative disability, co‐ordination problems, choreiform dyskinesia and hypotonia. The normal group was subdivided into those who had been normal at 12 years and those who had had MND. All types of MND were related to cognitive and behavioural problems. Fine manipulative disability was related to behavioural and cognitive difficulties; co‐ordination problems to learning difficulties; and choreiform dyskinesia and hypotonia were related to attention difficulties and school failure, notwithstanding normal IQ. Besides k1ND. socio‐economic class, family adversities and female gender contributed to the development of behavioural and cognitive problems. The behaviour of children with MND at 12 years who were normal at 14 years did not differ from that of normal children.
Improving consistence of phonetic transcription for text-to-speech

Grapheme-to-phoneme conversion is an important step in speech segmentation and synthesis. Many approaches are proposed in the literature to perform appropriate transcriptions: CART, FST, HMM, etc. In this paper we propose the use of an automatic algorithm that uses the transformation-based errordriven learning to match the phonetic transcription with the speaker’s dialect and style. Different transcriptions based on word, part-of-speech tags, weak forms and phonotactic rules are validated. The experimental results show an improvement in the transcription using an objective measure. The articulation MOS score is also improved, as most of the changes in phonetic transcription affect coarticulation effects. Index Terms: speech synthesis, speech intelligibility, speech recognition, Hidden Markov models
FIR Filter Design Based on Successive Approximation of Vectors

We present a novel method for the design of finite impulse response (FIR) filters with discrete coefficients that belong in the sum of powers-of-two (POT) space. The importance of this class of filters cannot be overstated, given the ever-increasing number of applications for which a specific hardware implementation is needed. Filters that have coefficients that belong to such a class are also referred to as multiplierless filters, given that the operations performed by the filter can all be implemented by using appropriately designed shifts of the input data, making them a perfect choice whenever implementation simplicity and processing speed are the ultimate goal. To produce such a design, we employ a vector successive approximation technique successfully used in data compression that has a very low computational complexity, the Matching Pursuits Generalized BitPlanes algorithm (MPGBP). We derive optimality conditions for the approximation dictionary. We compare filters obtained with the proposed method with those derived in previous works. Based on this comparative analysis, we show that this new and powerful way of producing the filters' coefficients is also among the simplest available in the literature.