Miracle-dz/UniFAR-FTUs huggingface dataset:
New Guideline for the Reporting of Studies Developing, Validating, or Updating a Multivariable Clinical Prediction Model: The TRIPOD Statement

Prediction models are developed to aid health care providers in estimating the probability that a specific outcome or disease is present (diagnostic prediction models) or will occur in the future (prognostic prediction models), to inform their decision making. Prognostic models here also include models to predict treatment outcomes or responses; in the cancer literature often referred to as predictive models. Clinical prediction models have become abundant. Pathology measurement or results are frequently included as predictors in such prediction models, certainly in the cancer domain. Only when full information on all aspects of a prediction modeling study are clearly reported, risk of bias and potential usefulness of the prediction model can be adequately assessed. Many reviews have illustrated that the quality of reports on the development, validation, and/or adjusting (updating) of prediction models, is very poor. Hence, the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) initiative has developed a comprehensive and user-friendly checklist for the reporting of studies on, both diagnostic and prognostic, prediction models. The TRIPOD Statement intends to improve the transparency and completeness of reporting of studies that report solely on development, both development and validation, and solely on the validation (with or without updating) of diagnostic or prognostic, including predictive, models.
INFSO-ICT-216284 SOCRATES D2.4 Framework for the development of self-organisation methods

The SOCRATES (Self-Optimisation and self-ConfiguRATion in wirelEss networkS) project aims at the development of self-organisation methods for LTE radio networks. Self-organisation comprises self-optimisation, self-configuration and self-healing. Within this document a framework, or guidelines, are laid out that are to be the basis for the development of self-organisation functionalities within SOCRATES. These guidelines describe requirements set by network and OAM architecture, the need for the clustering of radio parameters (to be tuned by self-organisation algorithms) into so-called functional groups, the interrelationships and dependencies between use cases, and a methodology for the development of self-optimisation algorithms. In addition a prioritisation of the use cases defined in SOCRATES deliverable D2.1 is provided. The framework shall contribute to developing self- organisation solutions in WP3 and WP4 that base on a common set of ideas, rules and principles.
A new TCP Bandwidth Estimation protocol for satellite networks

Satellite communications represent an important slice of the global communications sector thanks to their broadcast nature. Unfortunately, TCP used on satellite links suffers from a number of well-known performance issues, especially for high altitude satellites with longer delays. In this paper, a new TCP protocol is proposed. This new protocol arises after a careful study of the various protocols present in literature that try to resolve the typical satellite issues. Our TCP protocol is called Available bandwidth adaptable Transport Protocol (ATP) and it takes the advantages of two TPC protocols proposed in literature: Satellite Transport Protocol (STP) and TCP Jersey. In particular, it consists of a reviewed version of STP protocol with the addition of the TCP Jersey Bandwidth Estimation algorithm called Available Bandwidth Estimation (ABE). In order to show the goodness of the proposed protocol we have performed some comparisons between ATP, STP, TCP Jersey and another TCP protocol called Satellite Communication Transmission Protocol (SCPS-TP).
Sleep Extension Improves Neurocognitive Functions in Chronically Sleep-Deprived Obese Individuals

Background Sleep deprivation and obesity, are associated with neurocognitive impairments. Effects of sleep deprivation and obesity on cognition are unknown, and the cognitive long-term effects of improvement of sleep have not been prospectively assessed in short sleeping, obese individuals. Objective To characterize neurocognitive functions and assess its reversibility. Design Prospective cohort study. Setting Tertiary Referral Research Clinical Center. Patients A cohort of 121 short-sleeping (<6.5 h/night) obese (BMI 30–55 kg/m2) men and pre-menopausal women. Intervention Sleep extension (468±88 days) with life-style modifications. Measurements Neurocognitive functions, sleep quality and sleep duration. Results At baseline, 44% of the individuals had an impaired global deficit score (t-score 0–39). Impaired global deficit score was associated with worse subjective sleep quality (p = 0.02), and lower urinary dopamine levels (p = 0.001). Memory was impaired in 33%; attention in 35%; motor skills in 42%; and executive function in 51% of individuals. At the final evaluation (N = 74), subjective sleep quality improved by 24% (p<0.001), self-reported sleep duration increased by 11% by questionnaires (p<0.001) and by 4% by diaries (p = 0.04), and daytime sleepiness tended to improve (p = 0.10). Global cognitive function and attention improved by 7% and 10%, respectively (both p = 0.001), and memory and executive functions tended to improve (p = 0.07 and p = 0.06). Serum cortisol increased by 17% (p = 0.02). In a multivariate mixed model, subjective sleep quality and sleep efficiency, urinary free cortisol and dopamine and plasma total ghrelin accounted for 1/5 of the variability in global cognitive function. Limitations Drop-out rate. Conclusions Chronically sleep-deprived obese individuals exhibit substantial neurocognitive deficits that are partially reversible upon improvement of sleep in a non-pharmacological way. These findings have clinical implications for large segments of the US population. Trail registration www.ClinicalTrials. gov NCT00261898. NIDDK protocol 06-DK-0036
Spatial Distributions of Guidance Molecules Regulate Chemorepulsion and Chemoattraction of Growth Cones

It is generally assumed that gradients of chemotropic molecules are instrumental to the wiring of the nervous system. Recently, two members of the secreted class III semaphorin protein family have been implicated as repulsive (Sema3A) and attractive (Sema3C) guidance molecules for cortical axons (Bagnard et al., 1998). Here, we show that stabilized gradients of increasing semaphorin concentrations elicit stereotyped responses from cortical growth cones, independent of the absolute concentration and the slope of these gradients. In contrast, neither repulsive effects of Sema3A nor attractive effects of Sema3C were observed when axons were growing toward decreasing semaphorin concentrations. Thus, growth cone guidance by gradients of chemotropic molecules is robust and reproducible, because it is primarily independent of the exact dimensions of the gradients.
Path Problems in Temporal Graphs

Shortest path is a fundamental graph problem with numerous applications. However, the concept of classic shortest path is insufficient or even flawed in a temporal graph, as the temporal information determines the order of activities along any path. In this paper, we show the shortcomings of classic shortest path in a temporal graph, and study various concepts of "shortest" path for temporal graphs. Computing these temporal paths is challenging as subpaths of a "shortest" path may not be "shortest" in a temporal graph. We investigate properties of the temporal paths and propose efficient algorithms to compute them. We tested our algorithms on real world temporal graphs to verify their efficiency, and also show that temporal paths are essential for studying temporal graphs by comparing shortest paths in normal static graphs.
The link between behavioural type and natal dispersal propensity reveals a dispersal syndrome in a large herbivore

When individuals disperse, they modify the physical and social composition of their reproductive environment, potentially impacting their fitness. The choice an individual makes between dispersal and philopatry is thus critical, hence a better understanding of the mechanisms involved in the decision to leave the natal area is crucial. We explored how combinations of behavioural (exploration, mobility, activity and stress response) and morphological (body mass) traits measured prior to dispersal were linked to the subsequent dispersal decision in 77 roe deer Capreolus capreolus fawns. Using an unusually detailed multi-trait approach, we identified two independent behavioural continuums related to dispersal. First, a continuum of energetic expenditure contrasted individuals of low mobility, low variability in head activity and low body temperature with those that displayed opposite traits. Second, a continuum of neophobia contrasted individuals that explored more prior to dispersal and were more tolerant of capture with those that displayed opposite traits. While accounting for possible confounding effects of condition-dependence (body mass), we showed that future dispersers were less neophobic and had higher energetic budgets than future philopatric individuals, providing strong support for a dispersal syndrome in this species.
A comparative analysis and survey of handoff for VoIP applications in mobile IPv6 protocols

Internet access through mobile devices is used increasingly. Data communications via Internet performed by mobile users need to kept in order offering better services especially for live streaming application such as VoIP. However, since the movement of users changes rapidly to their attachment points (AP), the handoff process needs to be taken into account. Several MIPv6 protocols have been proposed by IETF to solve the continuity communication of users. Users are supposed to be unaffected by this handoff mechanism. Those protocols are analyzed in term of the required time (delay) it takes when the handoff occurs. The results of delay of the handoff process are then compared with QoS for VoIP applications so as to obtain a better MIPv6 protocol that fulfills VoIP requirements.
A faired quality of service assured MAC protocol for Mobile Adhoc Network

The primary responsibility of a medium access control (MAC) protocol in Adhoc Network is the distributed arbitration for the shared channel for transmission of packets. The performance of Adhoc Network depends upon the sincerity of the MAC protocol. The MAC protocol of this type of network should be distributed, faired & free from hidden and exposed terminal problem. It should also support real-time traffic, transmission power control & be compatible with directional antennas. Researchers have proposed many MAC protocol for MANET, but none of them are simultaneously distributed, faired and support Quality of Service besides being distributed. This paper proposes a new MAC protocol which is based on IEEE 802.11will address the QoS, fairness and multihop capability. Simulation was carried out to support quality of service from simulation it is observed that high prioritized traffics have larger throughput and transmission capability as comapared to the low prioritized traffics.
Physical activity recognition using a single triaxial accelerometer and a barometric sensor for baby and child care in a home environment

In this paper, we describe and evaluate an activity recognition system using a single 3-axis accelerometer and a barometric sensor worn on a waist of the body. The purpose of this work is to prevent child accidents such as unintentional injuries at home. In order to prevent child accidents in the home and reduce efforts of parents, we present a new safety management system for babies and children. We collected labeled accelerometer data from babies as they performed daily activities which are standing still, standing up, sitting down, walking, toddling, crawling, climbing up, climbing down, stopping, wiggling, and rolling. In order to recognize daily activities, mean, standard deviation, and slope of time-domain features are calculated over sliding windows. In addition, the FFT analysis is adopted to extract frequency-domain features of the aggregated data, and then energy and correlation of acceleration data are calculated. We used the resulting training data to induce a predictive model for activity recognition. Naive Bayes, Bayes Net, Support Vector Machine, k-Nearest Neighbor, Decision Tree, Decision Table, Multilayer Perceptron, Logistic classifiers are tested on these features. Classification results using training and eight classifiers were compared. The overall accuracy of activity recognition was 96.2% using only a single wearable triaxial accelerometer sensor with the k-Nearest Neighbor.
Na/HCO3 Cotransporters in Rat Brain: Expression in Glia, Neurons, and Choroid Plexus

We studied the expression and distribution of Na/HCO3cotransporters in rat brain using polynucleotide probes and polyclonal antibodies derived from the electrogenic rat kidney Na/HCO3cotransporter (rkNBC). In whole brain, we observed a single mRNA (∼7.5 kb) by Northern hybridization and a major ∼130 kDa protein by immunoblotting with a polyclonal antiserum directed against the C terminus of rkNBC. NBC mRNA and protein were present in cortex, brainstem–diencephalon, and cerebellum. In situhybridization revealed NBC mRNA expression throughout the CNS, with particularly high levels in olfactory bulb, hippocampal dentate gyrus, and cerebellum. NBC mRNA was present in glial cells (e.g., Bergmann glia of cerebellum and hippocampal astrocytes) and neurons (e.g., granule cells of dentate gyrus and neurons of cortex or striatum). Double hybridization of mRNA encoding NBC and glutamate transporter 1 (glial marker) confirmed that both glia and neurons express NBC. Indirect immunofluorescence microscopy demonstrated NBC protein throughout the CNS, particularly in hippocampus and cerebellum. Although NBC mRNA was restricted to cell bodies, NBC protein was distributed diffusely, compatible with a localization in cell processes and perhaps cell bodies. Double labeling with glial fibrillary acidic protein (astrocytic marker), microtubule-associated protein 2 (neuronal marker), or 2′,3′-cyclic mononucleotide 3′-phosphodiesterase (oligodendrocytic marker) demonstrated expression of NBC protein in specific subpopulations of both glia and neurons. Moreover, NBC protein was present in both cultured hippocampal astrocytes and cortical neurons. NBC mRNA and protein were also present in epithelial cells of choroid plexus, ependyma, and meninges. Our results are thus consistent with multiple novel roles for Na/HCO3 cotransport in CNS physiology.
Contribution of correlated noise and selective decoding to choice probability measurements in extrastriate visual cortex

Trial by trial covariations between neural activity and perceptual decisions (quantified by choice Probability, CP) have been used to probe the contribution of sensory neurons to perceptual decisions. CPs are thought to be determined by both selective decoding of neural activity and by the structure of correlated noise among neurons, but the respective roles of these factors in creating CPs have been controversial. We used biologically-constrained simulations to explore this issue, taking advantage of a peculiar pattern of CPs exhibited by multisensory neurons in area MSTd that represent self-motion. Although models that relied on correlated noise or selective decoding could both account for the peculiar pattern of CPs, predictions of the selective decoding model were substantially more consistent with various features of the neural and behavioral data. While correlated noise is essential to observe CPs, our findings suggest that selective decoding of neuronal signals also plays important roles. DOI: http://dx.doi. org/10.7554/eLife.02670. 001
Interorganizational Systems and Transformation of Interorganizational Relationships: A Relational Perspective

Increasingly, organizations have been investing heavily in information systems to support greater cooperation with key business partners. However, the adoption of such interorganizational systems appears to depend not only on the firm’s perspective and internal contingencies, but also on the complementary perspective and contingencies of each of its key partners. Drawing on three IS theoretical perspectives and three views of competitive advantage, this study first develops a relational perspective which we posit to have general conceptual applicability in several different contexts including adoption, diffusion and success of dyadic IOS implementations. In this current study, the relational perspective is operationalized in the specific context of dyadic IOS adoption, and its applicability is being demonstrated in two parts via case studies in the context of the BookNet and CoreNet projects in Singapore. The insights gained and the lessons learned from the experiences of these case-study companies may hold valuable implications for both IS research and practice.
Fringing Field Effect in the Lumped-Capacitance Method for Permittivity Measurement

Theoretical analysis of the fringing field effect in the lumped-capacitance method for permittivity measurement for both shunt- and series-capacitor methods is given. It is shown that while the measured real part of the complex permittivity is larger than the true value by a factor depending on the ratio of the fringing to the parallel-plate capacitances, the imaginary part is not affected by the fringing field.
The first case of feline sinonasal aspergillosis due to Aspergillus fischeri in Japan

Feline upper respiratory tract infection due to Aspergillus spp. is considered an emerging disease, with the number of reported cases continuing to rise. In this study, we report the first case of feline sinonasal aspergillosis caused by Aspergillus fischeri in Japan. The patient presented after 2 months of progressive facial deformity around the nose and nasal discharge. The isolate from this case was susceptible to itraconazole (ITZ), voriconazole and micafungin, but was resistant to amphotericine B. However, the infected cat died approximately 1 month after referral, despite treatment for 12 days ITZ administered orally at 10 mg/kg.
By Adjusting Keyword Frequency and Separating Keyword into Different Layers to Improve Readability of KeyGraph in Decision Making

One drawback of KeyGraph is its poor readability. Providing qualified documents are expected helpful for KeyGraph to translate the documents an appropriate and easy read KeyGraph diagram. And further, to discover worthy chances for decision making. We proposed 2 preprocessing strategies for assuring appropriate quality of documents, especially for decision makers when they try to discover chances with KeyGraph. A case study of INSTANT MESSAGER is used to verify the validity and readability of the proposed strategies. The results shown that the proposed strategies are helpful for creating readability KeyGraph diagrams, and further to create clear scenarios for discovering chances.
A New Method for Solving the Point-Correspondence Problem between Two Shapes and Their Similarity Calculation

There are plenty of different algorithms for aligning pairs of 2D- shapes and point-sets. They mainly concern with the establishment of corre- spondences and the detection of outlier. All of them assume that the aligned shapes are quite similar in a way. But special problems arise if we have to align shapes that are very different, for example aligning concave to convex shapes. In such cases it is indispensable to take into account the order of the point-sets and to enforce legal sets of correspondences, otherwise the calculated distances are incorrect. We present our novel shape alignment algorithm which can also handle such cases. The algorithm establishes symmetric and legal one-to-one point correspondences between arbitrary shapes, represented as ordered sets of 2D-points and returns a distance measure which runs between 0 and 1.
Degrees of Freedom Region of the MIMO X channel with an Arbitrary Number of Antennas

We characterize the total degrees of freedom (DoF) of the full-rank MIMO X channel with arbitrary number of antennas at each node. We elucidate that the existing outer bound is tight for any antenna configuration and provide transmit and receive filter designs that attain this outer bound. The proposed achievable scheme exploits channel extensions in terms of both, symbol and asymmetric complex signaling when the communication is carried out over a constant channel case, and is also applicable to time varying channels. The proposed scheme represents a general framework for the derivation of the total DoF of any two-by-two multiuser channels. Furthermore, the rank-deficient MIMO channels case is naturally addressed, and it is shown that the total DoF of the interference (IC) and MIMO X channels are in general superior to the full rank MIMO case
Assessing the Diffusion of EDI Standards Across Business Communities

We study the diffusion of a universal EDI message standard. Overall diffusion of such standard may be hindered by the slowness of its development, and by the locally bounded nature of EDI positive network externalities. A model that captures these two factors is analyzed: two firms choose one of two possible standards whose performances evolve differently through time, they use either verbal negotiation or unilateral adoption as coordinating principle. It is shown that if the performance of the universal standard at the end of the game and/or the degree of interconnection between business communities are too low, then the chances for the standard to permeate from one community to another are rather weak.
Small Molecule Therapeutics NT 113 , a Pan-ERBB Inhibitor with High Brain Penetrance , Inhibits the Growth of Glioblastoma Xenografts with EGFR Ampli fi cation

This report describes results from our analysis of the activity and biodistribution of a novel pan-ERBB inhibitor, NT113, when used in treating mice with intracranial glioblastoma (GBM) xenografts. Approaches used in this investigation include: bioluminescence imaging (BLI) for monitoring intracranial tumor growth and response to therapy; determination of survival benefit from treatment; analysis of tumor IHC reactivity for indication of treatment effect on proliferation and apoptotic response; Western blot analysis for determination of effects of treatment on ERBB and ERBB signaling mediator activation; and high-performance liquid chromatography for determination of NT113 concentration in tissue extracts from animals receiving oral administration of inhibitor. Our results show that NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. In experiments including lapatinib and/or erlotinib, NT113 treatment was associated with the most substantial improvement in survival, as well as the most substantial tumor growth inhibition, as indicated by BLI and IHC results. Western blot analysis results indicated that NT113 has inhibitory activity, both in vivo and in vitro, on ERBB family member phosphorylation, as well as on the phosphorylation of downstream signaling mediator Akt. Results from the analysis of animal tissues revealed significantly higher NT113 normal brain-to-plasma and intracranial tumor-to-plasma ratios for NT113, relative to erlotinib, indicating superior NT113 partitioning to intracranial tissue compartments. These data provide a strong rationale for the clinical investigation of NT113, a novel ERBB inhibitor, in treating patients with GBM. Mol Cancer Ther; 13(12);