Miracle-dz/UniFAR-FTUs huggingface dataset:
The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

Despite therapeutic advances multiple myeloma remains largely incurable, and novel therapeutic concepts are needed. The Hsp90-chaperone is a reasonable therapeutic target, because it maintains oncogenic signaling of multiple deregulated pathways. However, in contrast to promising preclinical results, only limited clinical efficacy has been achieved through pharmacological Hsp90 inhibition. Because Hsp70 has been described to interact functionally with the Hsp90-complex, we analyzed the suitability of Hsp72 and Hsp73 as potential additional target sites. Expression of Hsp72 and Hsp73 in myeloma cells was analyzed by immunohistochemical staining and western blotting. Short interfering RNA-mediated knockdown or pharmacological inhibition of Hsp72 and Hsp73 was performed to evaluate the role of these proteins in myeloma cell survival and for Hsp90-chaperone function. Furthermore, the role of PI3K-dependent signaling in constitutive and inducible Hsp70 expression was investigated using short interfering RNA-mediated and pharmacological PI3K inhibition. Hsp72 and Hsp73 were frequently overexpressed in multiple myeloma. Knockdown of Hsp72 and/or Hsp73 or treatment with VER-155008 induced apoptosis of myeloma cells. Hsp72/Hsp73 inhibition decreased protein levels of Hsp90-chaperone clients affecting multiple oncogenic signaling pathways, and acted synergistically with the Hsp90 inhibitor NVP-AUY922 in the induction of death of myeloma cells. Inhibition of the PI3K/Akt/GSK3β pathway with short interfering RNA or PI103 decreased expression of the heat shock transcription factor 1 and down-regulated constitutive and inducible Hsp70 expression. Treatment of myeloma cells with a combination of NVP-AUY922 and PI103 resulted in additive to synergistic cytotoxicity. In conclusion, Hsp72 and Hsp73 sustain Hsp90-chaperone function and critically contribute to the survival of myeloma cells. Translation of Hsp70 inhibition into the clinic is therefore highly desirable. Treatment with PI3K inhibitors might represent an alternative therapeutic strategy to target Hsp70.
Benchmarking classification of earth-observation data: From learning explicit features to convolutional networks

In this paper, we address the task of semantic labeling of multisource earth-observation (EO) data. Precisely, we benchmark several concurrent methods of the last 15 years, from expert classifiers, spectral support-vector classification and high-level features to deep neural networks. We establish that (1) combining multisensor features is essential for retrieving some specific classes, (2) in the image domain, deep convolutional networks obtain significantly better overall performances and (3) transfer of learning from large generic-purpose image sets is highly effective to build EO data classifiers.
Edgebreaker: Compressing the incidence graph of triangle meshes

Edgebreaker is a simple scheme for compressing the triangle/vertex incidence graphs (sometimes called topology) of threedimensional triangle meshes. Edgebreaker improves upon the worst case and the expected compression ratios of previously reported schemes, most of which require O(nlogn) bits to store the incidence graph of a mesh of n triangles. Edgebreaker requires only 2n bits or less for simple meshes and can also support fully general meshes by using additional storage per handle and hole. EdgebreakerOs compression and decompression processes perform an identical traversal of the mesh from one triangle to an adjacent one. At each stage, compression produces an op-code describing the topological relation between the current triangle and the boundary of the remaining part of the mesh. Decompression uses these op-codes to reconstruct the entire incidence graph. Because EdgebreakerOs compression and decompression are independent of the vertex locations, Edgebreaker may be combined with a variety of vertex-compressing techniques that exploit topological information about the mesh to better estimate vertex locations. Edgebreaker may be used to transfer the entire surface bounding a 3D polyhedron or only a triangulated surface patch, for which the bounding loops are already known and need not be transferred. Its superior compression capabilities, the simplicity of its implementation, and its versatility make Edgebreaker the perfect candidate for the emerging 3D data exchange standards for interactive graphic applications. The paper sets geometric compression in a formal topological framework and offers a new comparative perspective on prior art.
Self-ratings of ADHD symptoms in adults I: Factor structure and normative data

Background: Although well-standardized behavior rating scales are routinely utilized in children for evaluations of Attention Deficit Hyperactivity Disorder (ADHD), comparable measures for adults with ADHD symptomatology have been sparse. Based on current literature and clinical experience, nine aspects of adult ADHD functioning provided initial hypotheses regarding factor structure and scale items for a new scale for self-rating of symptoms by adults suspected of having ADHD. Method: A normative sample of 839 subjects and a clinical sample of 167 subjects completed ratings of an initial pool of 93 items. Results: Exploratory and confirmatory factor analyses suggested a four-factor structure involving 42 items. These factors include Inattention/Cognitive Problems, Hyperactivity/Restlessness, Impulsivity/Emotional Lability, and Problems with Self-Concept. Conclusion: The scale appears to cover the core features of ADHD as seen in children and adolescents, while adding content unique to adult expression of the ADHD syndrome. The new scale (Conners' Adult ADHD Rating Scale, or CAARS) may provide a useful dimensional measurement system for research and clinical applications.
Parenting Styles: The Impact on Student Achievement

ABSTRACT Parenting style and its impact on student achievement in a multidimensional society continues to pose significant challenges to clinicians, researchers, educators, and parents alike. This literature review summarizes the research surrounding five domains: (1) parental control; (2) gender and parenting style; (3) parental education; (4) perceptual differences between parents and their children; and (5) ethnicity and diversity. Behavioral control and psychological control were found to be two inherent features of parental style that have a direct affect on student achievement. Adolescents' perceived level of independence when interacting with their parents also seemed to have a direct relationship on their academic achievement. Research concerning children's progress in mathematics as related to parenting style and gender stereotype was also uncovered. Evidence was found to support the notion that parental education can have an indirect impact on children's academic achievement in various cultures. Implications for future research are identified including the need for applied research in learning communities factoring in variables for family structure, expectations, ethnicity, communication, and involvement.
Beyond the Model Worker: Surveying a Creative Precariat

The figure of the self-reliant, risk-bearing, non-unionised, self-exploiting, alwayson flexibly employed worker in the creative industries has been positioned as a role model of contemporary capitalism. Although the notion of the model-worker is a compelling critical diagnostic of the self-management of precarity in postFordist times, I argue that it provides an insufficient perspective on labour and the so-called creative economy to the extent that it occludes the capacity to contest among the workforces it represents. Informed by a larger research project, this article thematises salient features of select collective responses to precarity that are emerging from workers in nonstandard employment in the arts, the media, and cultural industries. The discussion is structured in three main parts: the first, aggregation, identifies initiatives in which employment status – rather than a specific profession or sector – is the basis of assembly and advocacy; the second, compensation, highlights unpaid work as a growing point of contention across sectors; and the third, occupation, describes cases in which precarious cultural workers are voicing their grievances and engaging in direct action in the context of wider social movements. These dimensions of the contemporary response to precarisation in the creative industries are at risk of being overlooked if the research optic on workers’ strategies is focused upon a single sector or a particular profession. In conclusion, I emphasise that the organisations, campaigns, and proposals that are surveyed in this article are marked by tensions between and among accommodative adaption, incremental improvements, and radical reformism vis-a-vis precarity.
A Linear Algorithm for Disk Conformal Parameterization of Simply-Connected Open Surfaces

Surface parameterization is widely used in computer graphics and geometry processing. It simplifies challenging tasks such as surface registrations, morphing, remeshing and texture mapping. In this paper, we present a novel linear algorithm for computing the disk conformal parameterization of simply-connected open surfaces. A double covering technique is used to turn a simply-connected open surface into a genus-0 closed surface, and then a linear algorithm for parameterization of genus-0 closed surfaces can be applied. The symmetry of the double covered surface preserves the efficiency of the computation. A planar parameterization can then be obtained with the aid of a M\"obius transformation and the stereographic projection. After that, a normalization step is applied to guarantee the circular boundary. Finally, we achieve a bijective disk conformal parameterization by a composition of quasi-conformal mappings. Experimental results demonstrate a significant improvement in the computational time by over 60%. At the same time, our proposed method retains comparable accuracy, bijectivity and robustness when compared with the state-of-the-art approaches. Applications for texture mapping are considered for illustrating the effectiveness of our proposed algorithm.
Wireless Front-End With Power Management for an Implantable Cardiac Microstimulator

Inductive coupling is presented with the help of a high-efficiency Class-E power amplifier for an implantable cardiac microstimulator. The external coil inductively transmits power and data with a carrier frequency of 256 kHz into the internal coil of electronic devices inside the body. The detected cardiac signal is fed back to the external device with the same pair of coils to save on space in the telemetry device. To maintain the power reliability of the microstimulator for long-term use, two small rechargeable batteries are employed to supply voltage to the internal circuits. The power management unit, which includes radio frequency front-end circuits with battery charging and detection functions, is used for the supply control. For cardiac stimulation, a high-efficiency charge pump is also proposed in the present paper to generate a stimulated voltage of 3.2 V under a 1 V supply voltage. A phase-locked-loop (PLL)-based phase shift keying demodulator is implemented to efficiently extract the data and clock from an inductive AC signal. The circuits, with an area of 0.45 mm2, are implemented in a TSMC 0.35 μm 2P4M standard CMOS process. Measurement results reveal that power can be extracted from the inductive coupling and stored in rechargeable batteries, which are controlled by the power management unit, when one of the batteries is drained. Moreover, the data and clock can be precisely recovered from the coil coupling, and a stimulated voltage of 3.2 V can be readily generated by the proposed charge-pump circuits to stimulate cardiac tissues.
Underdetermined Blind Source Separation in Echoic Environments Using DESPRIT

The DUET blind source separation algorithm can demix an arbitrary number of speech signals using anechoic mixtures of the signals. DUET however is limited in that it relies upon source signals which are mixed in an anechoic environment and which are sufficiently sparse such that it is assumed that only one source is active at a given time frequency point. The DUET-ESPRIT (DESPRIT) blind source separation algorithm extends DUET to situations where sparsely echoic mixtures of an arbitrary number of sources overlap in time frequency. This paper outlines the development of the DESPRIT method and demonstrates its properties through various experiments conducted on synthetic and real world mixtures.
Integrating Social Features and Query Type Recognition in the Suggestion Track of CLEF 2015 Social Book Search Lab

The Social Book Search (SBS) Lab is part of CLEF 2015 lab series. This is the third time that the CYUT CSIE team attends the SBS track. Based on a full-text search engine, we build a social feature re-ranking system and introduce more knowledge on understanding the queries. We defined a set of rules to filtering out unnecessary books from the recommendation list. The official run results show that the system performance is improved from our previous system.
The Antibody Genetics of Multiple Sclerosis: Comparing Next-Generation Sequencing to Sanger Sequencing

We previously identified a distinct mutation pattern in the antibody genes of B cells isolated from cerebrospinal fluid (CSF) that can identify patients who have relapsing-remitting multiple sclerosis (RRMS) and patients with clinically isolated syndromes who will convert to RRMS. This antibody gene signature (AGS) was developed using Sanger sequencing of single B cells. While potentially helpful to patients, Sanger sequencing is not an assay that can be practically deployed in clinical settings. In order to provide AGS evaluations to patients as part of their diagnostic workup, we developed protocols to generate AGS scores using next-generation DNA sequencing (NGS) on CSF-derived cell pellets without the need to isolate single cells. This approach has the potential to increase the coverage of the B-cell population being analyzed, reduce the time needed to generate AGS scores, and may improve the overall performance of the AGS approach as a diagnostic test in the future. However, no investigations have focused on whether NGS-based repertoires will properly reflect antibody gene frequencies and somatic hypermutation patterns defined by Sanger sequencing. To address this issue, we isolated paired CSF samples from eight patients who either had MS or were at risk to develop MS. Here, we present data that antibody gene frequencies and somatic hypermutation patterns are similar in Sanger and NGS-based antibody repertoires from these paired CSF samples. In addition, AGS scores derived from the NGS database correctly identified the patients who initially had or subsequently converted to RRMS, with precision similar to that of the Sanger sequencing approach. Further investigation of the utility of the AGS in predicting conversion to MS using NGS-derived antibody repertoires in a larger cohort of patients is warranted.
Level 3 basic linear algebra subprograms for sparse matrices: a user-level interface

This article proposes a set of Level 3 Basic Linear Algebra Subprograms and associated kernels for sparse matrices. A major goal is to design and develop a common framework to enable efficient, and portable, implementations of iterative algorithms for sparse matrices on high-performance computers. We have designed the routines to shield the developer of mathematical software from most of the complexities of the various data structures used for sparse matrices. We have kept the interface and suite of codes as simple as possible while at the same time including sufficient functionality to cover most of the requirements of iterative solvers and sufficient flexibility to cover most sparse matrix data structures. An important aspect of our framework is that it can be easily extended to incorporate new kernels if the need arises. We discuss the design, implementation, and use of subprograms for the multiplication of a fully matrix by a sparse one and for the solution of sparse triangular systems with one or more (full) right-hand sides. We include a routine for checking the input data, generating a new sparse data structure from the input, and scaling a sparse matrix. The new data structure for the transformation can be specified by the user or can be chosen automatically by vendors to be efficient on their machines. We also include a routine for permuting the columns of a sparse matrix and one for permuting the rows of a full matrix.
An examination of differences between native and non-native psychiatric offenders on the MMPI

ABSTRACT MMPI scores of 57 native and 218 non-native Canadian Prairie psychiatric offenders were compared.In uncontrolled comparisons, considerable cross-cultural profile similarity was observed. Neverthe-less, natives displayed significantly higher scores on L, F, and Hs (p < .05), and tended towardssignificance on Sc (p < .08). Natives scored significantly lower on Mf. Next, separate native andnon-native multiple regressions were performed, using the 13 MMPI scales as criterion variableswith age, time served, education level, WAIS full scale IQ, and Verbal Comprehension as the predictors.Average /P's of . 26 (ns) and . 17 (p < .001) were observed for natives and non-natives, respective-ly. WAIS full scale IQ and education level were the strongest predictors of native and non-nativeMMPIs, respectively. When controlled MMPI comparisons were made using IQ and education ascovariates, the previous differences were erased. Profile similarity was still evident. With covari-ates, significantly lower native scores were found on Mf, Pa, and Si, while K was significantly higher.The lowered native profile was due primarily to the IQ covariate. It was concluded that the MMPIwas valid for use with native offenders where consideration is given to the secondary effects of IQand the limited influence of culture.
LTCC Spiral Inductor Synthesis and Optimization With Measurement Verification

In RF/microwave circuit design, inductor design is one of the most difficult and time-consuming tasks due to the tedious trial-and-error optimization process to achieve the target specifications such as inductance, quality factor and occupied space. This paper brings forward a fast spiral inductor synthesis method, which automatically generates physical layout of inductors according to electrical specifications. By fusion of substrate-aware partial element equivalent circuit (PEEC) model with nonlinear optimization engine, our modeling and synthesis strategies have been verified with industrial field solver and measurement results. Our calculation results got less than 7% error for inductance and less than 9% for quality factor as compared to the results from full-wave electromagnetic simulation software. This can provide a fast and good initial inductor design for designer.
A hybrid approach for color based image edge detection

Edge detection is an elementary step used in various image processing applications. The main problems in existing edge detection algorithms are poor edge localization, less noise removal capacity, unable to detect edges in complex background images and inability to properly detect the color edges in images. In this paper a sequential hybrid approach is proposed to overcome all the limitations of existing edge detection algorithms. The operations performed by image edge detection algorithm can be computationally expensive and takes lots of execution time for processing the data. This research work also improves hybrid color based image edge detection technique by using the data parallelism approach. The comparison among sequential and parallel edge detection will be drawn based upon different parallel metrics. The experimental results have shown that parallel strategy achieves a performance gain of 68% as compared to sequential approach.
Searching for the Unknowable: A Process of Detection — Abductive Research Generated by Projective Techniques

This article looks at the process of doing research ‘from scratch. ’ The author began a project investigating children of Ethiopian origin living in Israel to see how ones who attended a kindergartern program years earlier differed from those who had not attended. However, the problem from the outset was that there may not be a difference to find. In this article, the author compares inductive, deductive, and abductive reasoning, and argues that abductive reasoning is the proper technique when nothing is known about the research at the outset.
Encapsulation Status of Papillary Thyroid Microcarcinomas is Associated with the Risk of Lymph Node Metastases and Tumor Multifocality

Abstract The management of papillary microcarcinoma (PMC) of the thyroid is controversial, especially after partial thyroid resection for benign thyroid disease. In order to detect prognostic factors for PMC, we analyzed 116 patients with PMC for encapsulation status and lymph node metastases. Between 10/1992 and 12/2010, 116 patients with PMC have been operated in our department (87 females, 29 males, median age 49 years). Eighty per cent of PMCs were diagnosed postoperatively. Seventy-six patients (66%) received a more extended resection with either thyroidectomy, near total thyroidectomy, or Dunhill operation either primarily or after completion operation, whereas 40 patients (34%) had only partial resection. Fifty patients (43%) received radioiodine (RIA) ablation. Lymph node metastases were found in 21 patients (18%). Univariate analysis showed four risk factors to be significantly associated with the risk of lymph node metastasis (p<0.05): male gender, younger age, age group<50 years and nonencapsulation of the tumor. Multivariate analysis demonstrated statistical significance for gender and tumor capsulation status. The tumor capsulation status also correlated with tumor multifocality. Our data show that the risk of lymph node metastases is significantly higher in partially or nonencapsulated PMC than in encapsulated specimens. We therefore suggest that the WHO classification should be extended to a compulsory notification of the encapsulation status in PMC.
No Small Linear Program Approximates Vertex Cover within a Factor 2 -- e

The vertex cover problem is one of the most important and intensively studied combinatorial optimization problems. Khot and Regev [30], [31] proved that the problem is NP-hard to approximate within a factor 2 - ε, assuming the Unique Games Conjecture (UGC). This is tight because the problem has an easy 2-approximation algorithm. Without resorting to the UGC, the best in approximability result for the problem is due to Dinur and Safra [16], [17]: vertex cover is NP-hard to approximate within a factor 1.3606. We prove the following unconditional result about linear programming (LP) relaxations of the problem: every LP relaxation that approximates vertex cover within a factor of 2 - ε has super-polynomially many inequalities. As a direct consequence of our methods, we also establish that LP relaxations (as well as SDP relaxations) that approximate the independent set problem within any constant factor have super-polynomially many inequalities.