Miracle-dz/UniFAR-FTUs huggingface dataset:
Melanoma 8062 Melanoma 8064 Melanoma 8065 Melanoma 8102 Melanoma 8108 Melanoma 8066 Melanoma 8104 Melanoma 8063 Melanoma

We describe two methods of analyzing tissues for cellsurfaceantigens identified by monoclonal antibodies. The first method is a binding assay, in which a membrane fraction prepared by differential centrifugation of a tissue homogenate is incubated with ‘25l-labeled antibody. The specificity of the observed binding is established by competition with unlabeled antibody. The second method, double-determinant immunoassay, involves two monoclonal antibodies that recognize two distinct epitopes of the antigen molecule. An immunoadsorbent prepared from one of the antibodies is incubated with a detergent lysate of the tissue. The immunoadsorbent is then washed and Incubated with the 1251-labeledsecond antibody. In both assays the amount of radiolabeled antibody bound is proportional to the amount of antigen in the test sample, and the limit of detection is approximately 10 pg of antibody, corresponding to less than 1 fmol of antigen.
A 1/1.8-inch 6.4 MPixel 60 frames/s CMOS Image Sensor With Seamless Mode Change

A 1/1.8-inch 6.4 MPixel 60 frames/s CMOS image sensor fabricated in a 0.18-mum single-poly triple-metal (1P3M) process is described. A zigzag-shaped 1.75 T/pixel architecture and a 10-bit counter-type column parallel ADC enables 2.5times2. 5 mum2 pixels. The resulting pixel has 38% fill factor and 12ke-/lux.s sensibility. In addition, full frame and 2times2 binning modes are interchangeable without an extra invalid frame
The price of outsourcing: A content analysis of the effects of early deadlines on the sports section in The Oklahoman

Newspapers have begun outsourcing their printing to cut costs, and this study employs a content analysis to examine its effects on the award-winning sports section of The Oklahoman. Before outsourcing, it was a typical metropolitan daily covering all important games with few missing late scores. Afterward, problems associated with earlier deadlines and printing in another city included late delivery, incomplete or missing game coverage, and numerous missing scores. These problems led to complaints that the publisher acknowledged. The results indicate outsourcing has costs that management should consider before employing it. Although the newspaper followed economic principles, these problems could damage its reputation.
Computerized analysis of daily life motor activity for ambulatory monitoring.

The primary goal of an ambulatory monitoring of motor activities (AMMA) system is to document the occurrence of random and spontaneous motor activities (e.g., sitting, lying, standing, walking, running, etc.) of the ambulatory subject in natural environmental circumstances. Much progress has been made in recording fidelity, reduction in energy requirement, fixation of the accelerometers, equipment size and weight, memory capacity and data acquisition. At present, our laboratory is interested in developing an automated off-line AMMA-signal analysis system. The system has to take care of activity (wave) detection, recognition of onsets and endpoints of the various activities (waves), and computation of a set of relevant clinical parameters (e.g., total walking time, number of times rising from a chair, etc.) from long-term recorded data. Two methods are currently being used for computerizing the off-line analysis system: using an artificial neural network and using a set of selected features extracted from the input data. The present paper is aimed at the latter method. The method was successfully applied to long-term recorded data sets of eight male amputees and three other subjects. The primary results indicate that the method is a potentially useful too to computerize the off-line analysis system.
THREE ESSAYS ON FINANCIAL COLLABORATION IN THE GOVERNMENT AND NONPROFIT SECTORS

OF DISSERTATION THREE ESSAYS ON FINANCIAL COLLABORATION IN THE GOVERNMENT AND NONPROFIT SECTORS The primary objective of this dissertation is to study the management of public and nonprofit resources and financial risk. Governments will be able to use its findings to continue to provide public services in collaboration with other sectors, including the nonprofit sector. Nonprofit financial self-sufficiency and sub-award grant mechanisms between the government and nonprofit sectors are two primary areas to be examined. This dissertation consists of three essays. The first investigates how the diversification of nonprofit revenue portfolios influences extreme revenue risks; the results show that the chance of extreme revenue loss increases when revenue sources are highly correlated to each other. The second essay examines the impact of strenuous state fiscal conditions on nonprofit organizations based in different U.S. states in order to report on generalizable empirical research on sub-award grant mechanisms, state and local government grants awarded to nonprofit organizations. The third essay explores the nonprofit sector’s response to economic shocks, and whether specific state characteristics intensified or mitigated the impact of the economic crisis. The findings from this dissertation can help nonprofit-sector scholars and practitioners understand different perspectives of market risk, revenue risk and portfolio development, and financial stability related to government grants.
Heritability for adolescent antisocial behavior differs with socioeconomic status: gene-environment interaction.

BACKGROUND Socioeconomic status is often assumed to be of importance for the development of antisocial behavior, yet it explains only a fraction of the variance. One explanation for this paradox could be that socioeconomic status moderates the influence of genetic and environmental effects on antisocial behavior. METHOD TCHAD is a Swedish longitudinal population-based twin study that contains 1,480 twin pairs born 1985-1986. The present study included 1,133 twin pairs, aged 16-17 years. Antisocial behavior was measured through self-report. Family socioeconomic status was assessed by parental-reported education and occupational status. Neighborhood socioeconomic conditions were assessed using five aggregated level variables: ethnic diversity, basic educational level, unemployment level, buying power, and crime-rate. We used structural equation modeling to test whether socioeconomic status interacted with latent genetic and environmental effects for antisocial behavior. RESULTS Genetic influences on antisocial behavior were more important in adolescents in socioeconomically more advantaged environments, whereas the shared environment was higher in adolescents in socioeconomically less advantaged environments. Heritability for antisocial behavior was higher in girls than in boys, irrespective of socioeconomic background. CONCLUSIONS Our results suggest that different intervention policies should be considered in different socioeconomic areas. In socioeconomically advantaged areas, it might be more fruitful to focus on individually based preventions and treatments. In socioeconomically disadvantaged areas, intervention and prevention policies might be more effective on a community level, to account for shared environmental risk factors.
Structure and function of pili of pathogenic Neisseria species

Pili are hairlike filamentous appendages which extend several micrometers from the bacterial surface and have long had an important role in the pathogenesis of gonococcal infections. Pioneering studies by Kellogg et al. demonstrated that a loss of virulence was observed when gonococci were subjected to repeated laboratory subculture and that this change was associated with a change in colony morphology of the bacteria when grown on solid media (21). Four characteristically different colonial forms, designated types T1, T2, T3, and T4, could be observed; primary isolates produced predominantly small, domed, highlighted colonies (T1 and T2), whereas the laboratory subculture resulted in an increasing proportion of large, flat colonial forms (T3 and T4). Each type could, however, be stably maintained by careful colony selection during subculture, and T1-T2 colonial forms retained their virulence for human volunteers (20). Subsequent electron-microscopic studies revealed that the T1-T2 colonial forms produced pili, whereas the T3-T4 colonial forms did not (54). This association between piliation and virulence prompted a considerable body of work on the structure, function, immunochemistry, and genetics of gonococcal pili and, subsequently, related studies of meningococci.
Improvements in harmonic mitigation for multilevel AC-Drives for high power applications

Large Current Source PWM AC Drives needs either, a phase controlled rectifier or an Active Front End (AFE). Choosing the AFE implies to use optimized switching patterns in both, rectifiers and inverters. Several authors propose modular current source based AC-Drives (MCSC) as a practical way to handle currents larger than the devices capabilities. Standard SHE was extended to Multilevel Selective Harmonic Elimination (MSHE) for MCSC. MSHE change the harmonic spectra by subtracting the larger harmonics of the total current pattern. It results in cleaner multilevel patterns. This is not the case if symmetrical modulation indexes and balanced currents are not ensured. The inverters shape the output line current meanwhile the rectifiers independently balance the DC currents. Thus, the possibility of having rectifiers operating at asymmetrical conditions exists which generates a threat of harmonic pollution. An alternative approach to generate multilevel patterns in the rectifier stage of MCSC considers the use of Displaced SHE patterns (DSHE). This approach provides total elimination for low order harmonics as well as a reduction of the characteristic harmonics amplitude reducing the total distortion. This work presents the mathematical bases of the DSHE operation. Additionally, it compares the SHE, MSHE, and DSHE for the rectifiers of an MCSC. Simulated results validate the theoretical considerations.
STRATEGIES UNDERTAKEN BY HEALTH INSURANCE SCHEME TO ENHANCE CUSTOMER LOYALTY A CASE STUDY OF NATIONAL HOSPITAL INSURANCE FUND, UKUNDA BRANCH OFFICE

Purpose: The purpose of the study was to establish strategies undertaken by health insurance scheme to enhance customer loyalty. Methodology: The study adopted a descriptive research design. The target population of the study was a total of 175 external customers who belong to the civil service and disciplined forces scheme and are covered under the comprehensive outpatient scheme. The research sample size from the four stratums was approximately 120 respondents.Since the population confined to the four strata, the researcher used stratified random sampling. The study used questionnaires for data collection. Data was analyzed using descriptive and inferential statistical methods. Raw quantitative data was analyzed using regression analysis. The use of a computer package by the name of Statistical Package for Social Sciences (SSPS) was put to the test in tabulating and analyzing data. The data was analyzed using frequency tables, percentages, degrees and measures of central tendency. Results: The results of correlation revealed that pricing strategy, customer communication strategy, product innovation strategy and market research strategy were positively and significantly related. Pricing strategy, customer communication strategy, product innovation strategy and market research strategy were found to be satisfactory variables in explaining customer loyalty in NHIF. This was supported by coefficient of determination also known as the R square of 64.9%. Unique contribution to theory, practice and policy: The study recommended that while it was necessary to continuously improve on the current strategies, discovering new strategies so as to boost on customer loyalty should be encouraged at NHIF. Keywords: Strategies, health, insurance, scheme, customer, loyalty
Reverse transcriptase activity from human embryonal carcinoma cells NTera2D1.

We have identified an RNA‐dependent DNA polymerase activity in the microsomal fraction of human pluri‐potential embryonal carcinoma cells NTera2D1, which are known to express the full length coding strand of the genomic Line‐1 (L1) elements. This activity was classified as a reverse transcriptase (RT) based on its utilization of an RT specific synthetic poly(Cm) template in the presence of Mn2+ ions. Treatment of the cell by ultraviolet irradiation (200 erg/mm2) which resulted in a 2‐ to 3‐fold enhancement of the RT activity, was required for the reproducible detection of the activity throughout the entire purification procedure. More than a 100‐fold enrichment in RT activity was obtained by centrifugation in a glycerol step gradient and a linear sucrose density gradient followed by Sephacryl S‐1000 gel filtration. These experiments demonstrated that the RT activity was associated with a macromolecular complex having the characteristics of a viral‐like particle with a major protein component of 37 kd. The presence of L1 mRNA in RT‐containing fractions suggests that the activity identified could originate from L1 elements and/or be involved in the mechanism of retroposition.
MDS clinical diagnostic criteria for Parkinson's disease

This document presents the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (PD). The Movement Disorder Society PD Criteria are intended for use in clinical research but also may be used to guide clinical diagnosis. The benchmark for these criteria is expert clinical diagnosis; the criteria aim to systematize the diagnostic process, to make it reproducible across centers and applicable by clinicians with less expertise in PD diagnosis. Although motor abnormalities remain central, increasing recognition has been given to nonmotor manifestations; these are incorporated into both the current criteria and particularly into separate criteria for prodromal PD. Similar to previous criteria, the Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity. Explicit instructions for defining these cardinal features are included. After documentation of parkinsonism, determination of PD as the cause of parkinsonism relies on three categories of diagnostic features: absolute exclusion criteria (which rule out PD), red flags (which must be counterbalanced by additional supportive criteria to allow diagnosis of PD), and supportive criteria (positive features that increase confidence of the PD diagnosis). Two levels of certainty are delineated: clinically established PD (maximizing specificity at the expense of reduced sensitivity) and probable PD (which balances sensitivity and specificity). The Movement Disorder Society criteria retain elements proven valuable in previous criteria and omit aspects that are no longer justified, thereby encapsulating diagnosis according to current knowledge. As understanding of PD expands, the Movement Disorder Society criteria will need continuous revision to accommodate these advances. © 2015 International Parkinson and Movement Disorder Society
Ties that bind : examing the effects of social exchange variables on turnover intentions among executives

ii DEDICATION. v ACKNOWLEDGEMENTS. vii LIST OF TABLES. xi LIST OF FIGURES. xii CHAPTER I. THE RESEARCH PROBLEM. 1 Statement of the Problem. 1 Purpose of the Study. 3 Background and Need for the Study. 3 Theoretical Foundation. 8 Research Questions. 14 Research Model. 14 Definition of Terms. 15 Limitations. 17 Significance. 19 Summary. 20 II. REVIEW OF RELATED LITERATURE . 2
Clinical and Neuropsychological Features Associated with Structural Imaging Patterns in Patients with Mild Cognitive Impairment

Aim: To describe the clinical and neuropsychological features of mild cognitive impairment (MCI) patients with medial temporal atrophy (MTA), white matter hyperintensities (WMH), both, and neither and to assess whether the rate of progression differs among groups. Methods: Ninety-five MCI patients were divided into 4 groups based on the presence of MTA and WMH: 29 were MTA– WMH–, 11 MTA– WMH+, 23 MTA+ WMH–, and 32 MTA+ WMH+. MCI patients were compared with 30 normal subjects. MTA and WMH were assessed with MR-based visual rating scales. Subjects underwent an extensive clinical and neuropsychological investigation. Fifty-six underwent follow-up evaluation. Results: MTA– WMH– had relatively good neuropsychological performance, little vascular and physical comorbidity. MTA– WMH+ performed poorly only on executive neuropsychological tests. MTA+ WMH– patients had poor neuropsychological performances (mainly on memory tests), high physical and vascular comorbidity. MTA+ WMH+ were impaired in neuropsychological performances, had a high number of physical diseases and severe vascular comorbidity. On follow-up, 25% of MTA+ WMH– and 32% of MTA+ WMH+ and none in MTA– WMH– and in MTA– WMH+ converted to dementia (p = 0.05, log rank test). Conclusion: Structural neuroimaging can identify subgroups of MCI patients with specific clinical and neuropsychological features.
A. baumannii histone acetyl transferase Hpa2: optimization of homology modeling, analysis of protein–protein interaction and virtual screening

In the current scenario, widespread multidrug resistivity in ESKAPE pathogens demands identification of novel drug targets to keep their infections at bay. For this purpose, we have identified a novel target Hpa2 of A. baumannii, a member of GNAT superfamily of HATs. But due to sequence identity of equal or less than 35%, the correct sequence alignment and construction of 3D monomeric and dimeric models of Hpa2 having optimal structural parameters is a troublesome task. To circumvent these problems, we have designed an easy and optimized protocol for Hpa2 monomer modeling, and for generation of dimeric Hpa2 model using data-driven protein–protein docking experiment. Improvement in the structural features of generated model is an onerous process and generally achieved by paying time and computational cost. Herein, it is achieved by reconciliation of FoldX commands which takes less time in execution. Evaluations performed to validate structural parameters and stability of monomeric and dimeric Hpa2 attests to its quality. Analysis of interfacial residues, energy terms and RMSD values indicated a clear correlation between experimental and theoretical interface properties of the dimers, corroborating to the regime used for Hpa2 dimer generation. Structural information from the refined models was used for virtual screening of substrate-derived library and polyamines to achieve a new platform for developing A. baumannii inhibitory molecules. Molecules showing preferential binding at the dimer interface could be used as allosteric inhibitors. Binding of polyamines with model illustrated the same binding pattern as described experimentally in case of yeast Hpa2.
Analysis of factors that inhibiting implementation of Information Security Management System (ISMS) based on ISO 27001

The purpose of this research is to determine multi factors that inhibiting the implementation of the ISMS based on ISO 2700. It is also to propose a follow-up recommendation on the factors that inhibit the implementation of the ISMS. Data collection is derived from questionnaires to 182 respondents from users in data center operation (DCO) at bca, Indonesian telecommunication international (telin), and data centre division at Indonesian Ministry of Health. We analysing data collection with multiple linear regression analysis and paired t-test. The results are multiple factors which inhibiting the implementation of the ISMS from the three organizations which has implement and operate the ISMS, ISMS documentation management, and continual improvement. From this research, we concluded that the processes of implementation in ISMS is the necessity of the role of all parties in succeeding the implementation of the ISMS continuously.
Ignoring personal moral compass: factors shaping bankers’ decisions

Purpose The purpose of this paper is to increase our understanding of the challenges the banking industry continues to face from an ethics standpoint more than a decade after the credit crisis. Since 2007, there has been renewed interest in the way professional ethics is integrated within the banking culture. With a public that has become more sensitive towards ethical and corporate governance failures, the banking industry has been at the receiving end of strong ethical criticism. Yet, in spite of the regulatory response to the crisis, ethics is still a major issue in an industry where the corporate governance systems implemented by companies have failed to control employee behaviours, even in institutions branding themselves as ethical banks. Design/methodology/approach This paper studies factors inside and around institutions in the banking industry that impact the moral anomie in bankers’ professional environment. This paper applies an ordinary least square regression analysis, preceded by exploratory and confirmatory factor analysis, to test the hypothesised relations between anomie and the factors proposed. Findings The results show that long-term orientation, strategic aggressiveness and competitive intensity do have an influence on anomie. These results are compared to previous research applied in non-financial industries and prompt the strengthening of corporate governance systems in financial companies with aggressive corporate cultures. Originality/value The paper therefore introduces the factors that lead bankers to ignore the morals they gained from society and provide a better understanding of the reasons behind the deviant behaviours that caused the crisis a decade ago. It represents a crucial first step for future policymaking that fills an important gap in the financial regulation literature. Indeed, the lack of understanding of the factors dictating behaviours in the industry meant that regulatory changes in the past decade have mostly focussed on technical aspects of the problem (e.g. new capital structure requirements) and produced few answers to address the ethical challenges.
Competition and efficiency issues in electricity supply in England and Wales

The thesis examines competition and efficiency in the liberalised electricity industry of England and Wales after 1990. Literature review and economic analysis is undertaken for four activities: generation and trading arrangements; transmission pricing; comparative efficiency in distribution; and competition and access in supply. In trading arrangements and distribution, the analysis is supplemented by empirical work using both event study models and non-parametric efficiency analysis. Broad conclusions are that there is some evidence of generators behaving strategically in the pool, and productivity is variable among the distribution companies, with the increase attributable to the industry as a whole. [Continues. ]
Measurement of the nonlinear coefficient of optical fibers by femtosecond pulses and spectral interferometry

Accurate measurements of the nonlinear coefficient /spl gamma/ of optical-communication fibers are performed by using 110-fs pulses. The nonlinear phase shift induced by self-phase modulation over a propagation length shorter than 1 m is detected by the spectral-interferometry technique. The value of /spl gamma/ is obtained by comparing the measured frequency-dependent nonlinear phase with the numerical solution of the nonlinear propagation equation.