Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning a Repression Network for Precise Vehicle Search

The growing explosion in the use of surveillance cameras in public security highlights the importance of vehicle search from large-scale image databases. Precise vehicle search, aiming at finding out all instances for a given query vehicle image, is a challenging task as different vehicles will look very similar to each other if they share same visual attributes. To address this problem, we propose the Repression Network (RepNet), a novel multi-task learning framework, to learn discriminative features for each vehicle image from both coarse-grained and detailed level simultaneously. Besides, benefited from the satisfactory accuracy of attribute classification, a bucket search method is proposed to reduce the retrieval time while still maintaining competitive performance. We conduct extensive experiments on the revised VehcileID dataset. Experimental results show that our RepNet achieves the state-of-the-art performance and the bucket search method can reduce the retrieval time by about 24 times.
Motherhood, Employment and the Development of Depression

A prospective inquiry of a largely working-class sample of women with children considers the effect of employment on risk of developing clinical depression. The hypothesis was that there would be a direct protective effect arising from employment once quality of other support was taken into account. In fact full-time working mothers were at high risk. This appeared to be explained by either prior work strain or a severe event involving ‘deviant’ behaviour on the part of husband/boyfriend or child. Neither factor was relevant for part-time workers. The severe events appeared to be particularly depressogenic for full-time workers because they represented either failure in the motherhood role or a sense of entrapment in an unrewarding work/domestic situation. However, those in part-time work had a low rate of onset compared with non-workers, and the difference appears to be related to non-working women feeling less secure about their marriages.
Career anchors of dentist leaders

Abstract Objective: The work of a health care leader is demanding; in order to cope, leaders need motivation and support. The occurrence of intrinsic factors called career anchors (combination of one’s competence, motives and values) could be a contributing factor in dentist leaders’ career decisions. The aim of our study was to identify dentist leaders’ career anchors and their association to dentist leaders’ retention or turnover of the leadership position. Material and methods: Materials were gathered in 2014 via an electronic questionnaire from 156 current (Leaders) or former (Leavers) Finnish dentist leaders. Career anchor evaluation was conducted by the questionnaire and scoring-table taken from Edgar Schein’s Career Anchors Self-Assessment. Both the most and the least important career anchors were detected by the highest and lowest scores and their occurrence reported as percentages. Associations between career anchor scores and tendency to stay were analyzed with logistic regression. Results: ‘Technical/Functional Competence’ and ‘Lifestyle’ were most frequently reported as the most important and ‘Entrepreneurial Creativity’ and ‘General Managerial Competence’ as the least important career anchors. However, a higher level of ‘General Managerial Competence’ anchor was most significantly associated with staying in a leadership position. Instead, ‘Pure Challenge’ and ‘Lifestyle’ decreased the odds to stay. Conclusions: The knowledge of the important and essential career anchors of dentist leaders’ and individuals’ could perform crucial part in career choices and also in planning education, work opportunities and human resource policies promoting retention of dentist leaders and probably also other health care leaders.
Reconciling Scientists' Beliefs about Radiation Risks and Social Norms: Explaining Preferred Radiation Protection Standards

Social scientists have argued about the role of political beliefs in highly charged policy debates among scientific experts. In debates about environmental hazards, the focus of contention is likely to rest on the appropriate scientific assumptions to inform safety standards. When scientific communities are polarized, one would expect to find systematic differences among combatants in the choice of appropriate assumptions, and variation in the application of “precaution” in standard setting. We test this proposition using an experiment applied in a mail survey format to groups of scientists from opposing sides of the nuclear policy debate. Questions were asked about the role of political, social, and epistemological beliefs in reaching scientific and policy judgments about the relationship between radiation dose and cancer incidence in human populations. We find that the precautionary tendency is pervasive regardless of whether the scientist is associated with a putatively pro‐ or anti‐nuclear group. Using a multinomial logit model, we explain a modest percentage of the variation in the choice of preferred judgments about safety standards, but find that distinct sets of political and social values are significantly associated with policy positions among scientists. Implications for scientific advice to policymakers are discussed.
Resting brain connectivity: changes during the progress of Alzheimer disease.

PURPOSE To investigate alterations in functional connectivity in the resting brain networks in healthy elderly volunteers and patients with mild, moderate, or severe Alzheimer Disease (AD). MATERIALS AND METHODS This study was approved by the institutional ethics committee, and informed consent was obtained. Forty-six patients with AD and 16 healthy elderly volunteers were prospectively examined. Resting-state functional magnetic resonance imaging was used to detect alterations in posterior cingulate cortex (PCC) functional connectivity through a comparison of the healthy control group with three separate AD groups-mild, moderate, and severe AD. A temporal correlation method was used to obtain PCC connectivity maps. RESULTS Dissociated functional connectivity between the PCC and a set of regions, including the visual cortices bilaterally, the inferior temporal cortex, the hippocampus, and especially the medial prefrontal cortex and the precuneus and/or cuneus, was observed in all AD groups. The disruption of connectivity intensified as the stage of AD progression increased. There were also regions that exhibited increased connectivity; these regions extended from left lateralized frontoparietal regions and spread to bilateral frontoparietal regions along with AD progression. CONCLUSION Changes in PCC functional connectivity comprised bidirectional alterations in the resting networks in AD-affected brains, and the impaired resting functional connectivity seemed to change with AD progression. Therefore, alterations in functional connectivity in the default mode network might play a role in the progression of AD.
Clusters of DNA Double-Strand Breaks Induced by Different Doses of Nitrogen Ions for Various LETs: Experimental Measurements and Theoretical Analyses

Abstract Fakir, H. , Sachs, R. K. , Stenerlöw, B. and Hofmann, W. Clusters of DNA Double-Strand Breaks Induced by Different Doses of Nitrogen Ions for Various LETs: Experimental Measurements and Theoretical Analyses. Radiat. Res. 166, 917– 927 (2006). The yields and clustering of DNA double-strand breaks (DSBs) were investigated in normal human skin fibroblasts exposed to γ rays or to a wide range of doses of nitrogen ions with various linear energy transfers (LETs). Data obtained by pulsed-field gel electrophoresis on the dose and LET dependence of DNA fragmentation were analyzed with the randomly located clusters (RLC) formalism. The formalism considers stochastic clustering of DSBs along a chromosome due to chromatin structure, particle track structure, and multitrack action. The relative biological effectiveness (RBE) for the total DSB yield did not depend strongly on LET, but particles with higher LET produced higher fractions of small DNA fragments, corresponding in the formalism to an increase in the average number of DSBs per DSB cluster. The results are consistent with the idea that DSB clustering along chromosomes is what leads to large RBEs of high-LET radiations for major biological end points. At a given dose, large fragments are less affected by the variability in LET than small fragments, suggesting that the two free ends in large fragments are often produced by two different tracks. The formalism successfully described an extra increase in small DNA fragments as dose increases and a related decrease in large fragments, mainly due to interlacing of DSB clusters produced along a chromosome by different tracks, since interlacing cuts larger DNA fragments into smaller ones.
Characterization of Neisseria cinerea, a nonpathogenic species isolated on Martin-Lewis medium selective for pathogenic Neisseria spp

An asaccharolytic, gram-negative, oxidase-positive diplococcus was isolated on Martin-Lewis medium from the cervix of a patient attending an arthritis clinic at Seattle Public Health Hospital, Seattle, Wash. This strain, NRL 32165, did not produce detectable acid from glucose, maltose, sucrose, fructose, mannitol, or lactose in either cystine Trypticase agar (BBL Microbiology Systems, Cockeysville, Md.) or modified oxidation-fermentation medium and was identified presumptively as a glucose-negative Neisseria gonorrhoeae strain, but was identified later as Neisseria cinerea on the basis of its biochemical reactions. Nitrate was not reduced, nitrite (0.001%, wt/vol) was reduced, and polysaccharide was not produced from sucrose. Proline, arginine, and cystine-cysteine were required for growth on defined medium. Strain NRL 32165 did not react with antigonococcal protein I monoclonal antibodies and did not produce immunoglobulin A protease. In DNA:DNA homology studies with N. gonorrhoeae NRL 8038 (F62) and N. cinerea type strain NRL 30003, strain NRL 32165 showed 95% homology relative to N. cinerea and 44% homology relative to N. gonorrhoeae. Thus, the identity of strain NRL 32165 was confirmed as N. cinerea (von Lingelsheim 1906) Murray 1939. Of all Neisseria spp. , N. cinerea is most likely to be misidentified as a glucose-negative N. gonorrhoeae strain.
Comparative assessment of different percutaneous endoscopic interlaminar lumbar discectomy (PEID) techniques.

BACKGROUND Percutaneous endoscopic lumbar discectomy is a common surgical treatment for lumbar disc herniation, and percutaneous endoscopic interlaminar lumbar discectomy (PEID) is commonly used for direct decompression of L5-S1. Like microdiscectomy, recurrence of herniation after endoscopic discectomy is an important problem. In this study, we aimed to decrease the recurrence after PEID using a new surgical technique. OBJECTIVES We propose a new surgical technique for reducing the recurrence after PEID for lumbar disc herniation. The new technique uses annular sealing after fragmentectomy. We compared clinical results and recurrent lumbar disc herniation (had radiculopathy and confirmed by MRI) between patients who underwent surgery with and without annular sealing during PEID. STUDY DESIGN Retrospective cohort study of patients undergoing PEID. METHODS A total of 224 patients with radiculopathy due to L5-S1 disc herniation who were treated by PEID with (91 patients) or without annular sealing (133) were included in this study. We compared the demographic characteristics (age, sex, height, weight, BMI, smoking status, and occupation), clinical results, and recurrence rates between the 2 groups. We classified recurrence according to time period (early recurrence ≤ 6 months, late recurrence > 6 months). RESULTS The study groups were demographically similar, and substantial improvement in clinical results was noted. There were 5 recurrences (5.5%) (2 early, 3 late recurrences) in the group with annular sealing, and 18 (13.5%) (13 early, 5 late recurrences) in the group without annular sealing. Early recurrence rates were significantly higher in the group without sealing (2 vs. 13, P = 0.029). Increasing age was associated with overall recurrence (P = 0.004) and late recurrence (P = 0.008), while operative technique correlated with early recurrence (P = 0.026). LIMITATIONS First, this study incorporates a retrospective design. Second, the operations were performed by 2 surgeons. Additionally, this is relatively a short-term follow-up study (mean 19.5 ± 5.0 months). CONCLUSIONS Though a learning curve is needed in order to become familiar with PEID, recurrence after PEID was associated with advanced age, and PEID with annular sealing resulted in lower early recurrence rates than without annular sealing. Thus, PEID with annular sealing may be a useful technique for reducing early recurrence.
rhBMP-2 significantly enhances guided bone regeneration.

BACKGROUND Previous studies have shown a limited potential for bone augmentation following guided bone regeneration (GBR) in horizontal alveolar defects. Surgical implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) significantly enhances bone regeneration in such defects; however, sufficient quantities of bone for implant dentistry are not routinely obtained. The objective of this study was to evaluate the potential of rhBMP-2/ACS to enhance GBR using a space-providing, macro-porous expanded polytetrafluoroethylene (ePTFE) device. METHODS Bilateral, critical size, supra-alveolar, peri-implant defects were surgically created in four Hound Labrador mongrel dogs. Two turned and one surface-etched 10-mm titanium dental implant were placed 5 mm into the surgically reduced alveolar ridge creating 5-mm supra-alveolar defects. rhBMP-2/ACS (rhBMP-2 at 0.2 mg/ml) or buffer/ACS was randomly assigned to left and right jaw quadrants in subsequent animals. The space-providing, macro-porous ePTFE device was placed to cover rhBMP-2/ACS and control constructs and dental implants. Gingival flaps were advanced for primary wound closure. The animals were euthanized at 8 weeks postsurgery for histologic and histometric analysis. RESULTS Bone formation was significantly enhanced in defects receiving rhBMP-2/ACS compared to control. Vertical bone gain averaged (+/- SD) 4.7 +/- 0.3 and 4.8 +/- 0.1 mm, and new bone area 10.3 +/- 2.0 and 8.0 +/- 2.5 mm2 at turned and surface-etched dental implants, respectively. Corresponding values for the control were 1.8 +/- 2.0 and 1.3 +/- 1.3 mm, and 1.8 +/- 1.3 and 1.2 +/- 0.6 mm2. Bone-implant contact in rhBMP-2-induced bone averaged 6.4 +/- 1.4% and 9.6 +/- 7.5% for turned and surface-etched dental implants, respectively (P=0.399). Corresponding values for the control were 14.6 +/- 19.4% and 23.7 +/- 9.7% (P=0.473). Bone-implant contact in resident bone ranged between 43% and 58% without significant differences between dental implant surfaces. CONCLUSIONS rhBMP-2/ACS significantly enhances GBR at turned and surface-etched dental implants. The dental implant surface technology does not appear to substantially influence bone formation.
Actitud y comportamiento de consumidores alemanes respecto al aceite de oliva: un análisis de grupo objetivo

Actitud y comportamiento de consumidores alemanes respecto al aceite de oliva: un analisis de sesiones de grupo objetivo (focus group). El mercado aleman tiene un buen potencial para los exportadores de aceite de oliva, dadas sus caracteristicas socioeconomicas y el bajo nivel de consumo. El trabajo muestra la investigacion realizada sobre la actitud de los consumidores alemanes baria el aceite de oliva desde un punto de vista cualitativo. Se realizaron sesiones de grupo objetivo (focus group) en Munich y Berlin, que sirvieron de base para el diseno de encuestas y trabajos cuantitativos extendidos a toda Alemania. Esta publicacion centra su interes en la importancia de los estudios cualitativos, dentro del contexto de analisis de mercado, batiendo una descripcion detallada de los grupos de Munich, sobre la planificacion programacion y operaciones de campo, exponiendo los analisis de datos y resultados finales. Se exponen tos principales temas analizados y las dimensiones mas significativas del consumidor aleman. Se especifican los motivos del consumo, la intensidad del mismo, calidad del producto, lugares de compra, comportamiento en la busqueda de informacion finalizando con la actitud, criticos y sugerencias.
Split Luciferase Complementation for Analysis of Intracellular Signaling

Bioluminescent proteins such as luciferases are unique analytical tools with high sensitivity and wide dynamic ranges. However, applicability of the proteins has remained limited to reporter gene analysis. Split luciferase complementation technique is a new powerful strategy to detect protein-protein interactions and their related intracellular signaling in living cells. This review presents a summary of recent topics for the analysis of biological events using split luciferase complementation techniques. Different applications such as G-protein-coupled receptor (GPCR) screening, monitoring phosphorylations, protein-protein interactions, and pH differences in living tissues are described.
Passive Heating Attenuates Post-exercise Cardiac Autonomic Recovery in Healthy Young Males

Post-exercise heart rate (HR) recovery (HRR) presents a biphasic pattern, which is mediated by parasympathetic reactivation and sympathetic withdrawal. Several mechanisms regulate these post-exercise autonomic responses and thermoregulation has been proposed to play an important role. The aim of this study was to test the effects of heat stress on HRR and HR variability (HRV) after aerobic exercise in healthy subjects. Twelve healthy males (25 ± 1 years, 23.8 ± 0.5 kg/m2) performed 14 min of moderate-intensity cycling exercise (40–60% HRreserve) followed by 5 min of loadless active recovery in two conditions: heat stress (HS) and normothermia (NT). In HS, subjects dressed in a whole-body water-perfused tube-lined suit to increase internal temperature (Tc) by ~1°C. In NT, subjects did not wear the suit. HR, core and skin temperatures (Tc and Tsk), mean arterial pressure (MAP) skin blood flow (SKBF), and cutaneous vascular conductance (CVC) were measured throughout and analyzed during post-exercise recovery. HRR was assessed through calculations of HR decay after 60 and 300 s of recovery (HRR60s and HRR300s), and the short- and long-term time constants of HRR (T30 and HRRt). Post-exercise HRV was examined via calculations of RMSSD (root mean square of successive RR intervals) and RMS (root mean square residual of RR intervals). The HS protocol promoted significant thermal stress and hemodynamic adjustments during the recovery (HS-NT differences: Tc = +0.7 ± 0.3°C; Tsk = +3.2 ± 1.5°C; MAP = −12 ± 14 mmHg; SKBF = +90 ± 80 a.u; CVC = +1.5 ± 1.3 a.u./mmHg). HRR and post-exercise HRV were significantly delayed in HS (e.g., HRR60s = 27 ± 9 vs. 44 ± 12 bpm, P < 0.01; HRR300s = 39 ± 12 vs. 59 ± 16 bpm, P < 0.01). The effects of heat stress (e.g., the HS-NT differences) on HRR were associated with its effects on thermal and hemodynamic responses. In conclusion, heat stress delays HRR, and this effect seems to be mediated by an attenuated parasympathetic reactivation and sympathetic withdrawal after exercise. In addition, the impact of heat stress on HRR is related to the magnitude of the heat stress-induced thermal stress and hemodynamic changes.
Orthogonal acoustic dimensions define auditory field maps in human cortex

The functional organization of human auditory cortex has not yet been characterized beyond a rudimentary level of detail. Here, we use functional MRI to measure the microstructure of orthogonal tonotopic and periodotopic gradients forming complete auditory field maps (AFMs) in human core and belt auditory cortex. These AFMs show clear homologies to subfields of auditory cortex identified in nonhuman primates and in human cytoarchitectural studies. In addition, we present measurements of the macrostructural organization of these AFMs into “clover leaf” clusters, consistent with the macrostructural organization seen across human visual cortex. As auditory cortex is at the interface between peripheral hearing and central processes, improved understanding of the organization of this system could open the door to a better understanding of the transformation from auditory spectrotemporal signals to higher-order information such as speech categories.
Alpha helix capping in synthetic model peptides by reciprocal side chain–main chain interactions: Evidence for an N terminal “capping box”

A significant fraction of the amino acids in proteins are alpha helical in conformation. Alpha helices in globular proteins are short, with an average length of about twelve residues, so that residues at the ends of helices make up an important fraction of all helical residues. In the middle of a helix, H‐bonds connect the NH and CO groups of each residue to partners four residues along the chain. At the ends of a helix, the H‐bond potential of the main chain remains unfulfilled, and helix capping interactions involving bonds from polar side chains to the NH or CO of the backbone have been proposed and detected. In a study of synthetic helical peptides, we have found that the sequence Ser‐Glu‐Asp‐Glu stabilizes the alpha helix in a series of helical peptides with consensus sequences. Following the report by Harper and Rose, which identifies SerXaaXaaGlu as a member of a class of common motifs at the N termini of alpha helices in proteins that they refer to as “capping boxes,” we have reexamined the side chain–main chain interactions in a varient sequence using 1H NMR, and find that the postulated reciprocal side chain‐backbone bonding between the first Ser and last Glu side chains and their peptide NH partners can be resolved: Deletion of two residues N terminal to the Ser‐Glu‐Asp‐Glu sequence in these peptides has no effect on the initiation of helical structure, as defined by two‐dimensional (2D) NMR experiments on this variant. Thus the capping box sequence Ser‐Glu‐Asp‐Glu inhibits N terminal fraying of the N terminus of alpha helix in these peptides, and shows the side chain–main chain interactions proposed by Harper and Rose. It thus acts as a helix initiating signal. Since normal a helix cannot propagate beyond the N terminus of this structure, the box acts as a termination signal in this direction as well. © 1994 John Wiley & Sons, Inc.