Miracle-dz/UniFAR-FTUs huggingface dataset:
Wonderful Renormalization

The so-called wonderful models of subspace arrangements, developed in [CP95] based on Fulton and MacPherson’s seminal paper [FM94], serve as a systematic way to resolve the singularities of Feynman distributions. In this thesis we continue the work of [BBK10] where wonderful models were used to solve the renormalization problem in position space. In contrast to the exposition there, instead of the subspaces in the arrangement of divergent loci we use the poset of divergent subgraphs as the main tool to describe the wonderful construction and the renormalization operators. This is based on [Fei05] where DeConcini-Procesi models were studied from a purely combinatorial viewpoint. The main motivation for this approach is the fact that both, the renormalization process and the model construction, are governed by the combinatorics of this poset. Not only simplifies this the exposition considerably, but it also allows to study the renormalization operators in more detail. Moreover, we explore the renormalization group in this setting, i.e. study how the renormalized distributions react to a change of renormalization points. We show that a so-called finite renormalization is expressed as a sum of distributions determined by divergent subgraphs. The bottom line is that as is well known, at the latest since the discovery of a Hopf algebra structure underlying renormalization the whole process of renormalization is governed by the combinatorics of Feynman graphs while the calculus involved plays only a supporting role. I thank everybody for everything!
elegans development in CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust

and proofing. formatted HTML, PDF, and XML versions will be made available after technical processing, editing, This PDF is the version of the article that was accepted for publication after peer review. Fully unrestricted use and redistribution provided that the original author and source are credited. permitting Creative Commons Attribution License This article is distributed under the terms of the elife.elifesciences. org at Sign up for alerts Stay current on the latest in life science and biomedical research from eLife. Abstract 15 Genetic redundancy and pleiotropism have limited the discovery of functions associated with miRNAs and 16 other regulatory mechanisms. To overcome this, we performed an enhancer screen for developmental defects 17 caused by compromising both global miRISC function and individual genes in C. elegans. Among 126 18 interactors with miRNAs, we surprisingly found the CED-3 caspase that has only been well studied for its role 19 in promoting apoptosis, mostly through protein activation. We provide evidence for a non-apoptotic function of 20 CED-3 caspase that regulates multiple developmental events through proteolytic inactivation. Specifically, LIN-21 14, LIN-28 and DISL-2 proteins are known miRNA targets, key regulators of developmental timing, and/or stem 22 cell pluripotency factors involved in miRNA processing. We show CED-3 cleaves these proteins in vitro. We 23 also show CED-3 down-regulates LIN-28 in vivo, possibly rendering it more susceptible to proteasomal 24 degradation. This mechanism may critically contribute to the robustness of gene expression dynamics 25 governing proper developmental control.
Teaching Object-oriented Simulation in a Software Engineering Framework

Each year, object-oriented methodology (including its three main aspects—analysis, design, and programming) has been gaining more and more acceptance from the soft ware industry. This acceptance is preceded by multi-disci plinary research in the fields of simulation, artificial intel ligence, computer science, and software engineering. Year after year, new computer science and engineering pro grams produce graduates that join the ranks of software systems developers. Software industry representatives fre quently complain that the newcomers lack skills in practi cal aspects of software engineering. Another deficiency of undergraduate programs has been caused by traditional approach to teaching procedural programming. In the last few years, more programs started using C++ or Java for introductory computer science classes. However, in many cases, the teaching methodology did not change and the objects are introduced as an afterthought. This paper de scribes a junior-level course in an undergraduate com puter science program, designed to teach object-oriented design and coding, while introducing discrete modeling and computer simulation concepts. Additionally, the course provides a vehicle for development of small team class projects addressing critical aspects of the modern software development life cycle. The author's experience with teaching the course may serve as a model for similar offerings in other colleges and universities.
Living Outcome After Ischemic Hemispheric Stroke : Does Early Poststroke Diagnostic Accuracy of the Barthel Index for Measuring Activities of Daily

Gert Kwakkel, Janne M. Veerbeek, Barbara C. Harmeling-van der Wel, Erwin van Timing of Assessment Matter? Living Outcome After Ischemic Hemispheric Stroke : Does Early Poststroke Diagnostic Accuracy of the Barthel Index for Measuring Activities of Daily ISSN: 1524-4628 Copyright © 2010 American Heart Association. All rights reserved. Print ISSN: 0039-2499. Online Stroke is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 72514 doi: 10.1161/STROKEAHA.110. 599035 2011, 42:342-346: originally published online December 23, 2010 Stroke http://stroke.ahajournals. org/content/42/2/342 located on the World Wide Web at: The online version of this article, along with updated information and services, is
Efficient automatic segmentation of vessels

The segmentation of tubular structures is still an open field of investigation, particularly in medical imaging, where the quality of the image is poor with respect to natural images. Despite the quality of state-of-the-art segmentation methods, little effort has been devoted to the computational efficiency of the algorithms. Efficiency is an important topic, since intra-operative computer assisted interventions require near real-time performance. In this paper, we present a simple, yet effective, algorithm that efficiently segments vessels in 2D images. The algorithm requires no initialization and has a computational cost of O(SN logN), where S is the number of scales and N is the number of image pixels. Results on the DRIVE dataset show that the proposed method has near state-of-the-art performance with very little computational burden.
When You Have Lived in a Different Culture, Does Returning ‘Home’ Not Feel Like Home? Predictors of Psychological Readjustment to the Heritage Culture

Many repatriates find it challenging to readjust to their heritage culture after spending a significant period of time abroad. Research on predictors of readjustment, however, remains limited. The present study in particular investigated the identification of third culture individuals (TCIs) – that is, individuals who spent their formative years outside of their heritage culture - with an abstract, third culture. Our findings demonstrated that TCIs’ identification with the third culture was empirically distinct from that of the heritage and host cultures. The present study further examined whether several variables – sojourner type (TCI vs. non-TCI), perceived conflict between heritage and host culture, perceived cultural distance, and cultural identification with heritage and other cultures – predicted psychological readjustment (stress, anxiety, depression and overall psychological readjustment). The results showed that strong heritage culture identification was associated with better psychological readjustment, whereas cultural conflict was generally associated with poorer readjustment. Furthermore, sojourner type significantly moderated the latter association, such that cultural conflict predicted the stress aspect of psychological readjustment for non-TCIs, but not for TCIs. As the present investigation is the first study to empirically establish identification with a ‘third culture’ we discuss implications for the literature on third culture individuals and psychological adjustment upon re-entry.
A Framework for Predictive Web Prefetching at the Proxy Level using Data Mining

The intelligence of adapting to the needs of specific users has become a potential research area for web technologies amidst the problems like heterogeneous network connectivity, real-world distances, and congestion due to unexpected network demand. Web caching, one such adaptations, is a technology that helps to reduce the network usage and server loads and improve average latencies experienced by the user. Web latency would be further significantly reduced if proxy or Web server softwares could make predictions about the pages that a user is most likely to request next, while the user is viewing the current page, and prefetch their content. This technique is known as predictive web preftching. Both these techniques, along with the use of data mining mechanisms have been used in this paper for optimizing the access time for accessing web pages from a web server. In the proxy server, the proposed data mining based service would run in background mode. The service computes the web pages likely to be requested by the user, considering their past web access log history, using association rules and thus optimizing the access time.
Principles of maximum entropy and maximum caliber in statistical physics

The variational principles called maximum entropy (MaxEnt) and maximum caliber (MaxCal) are reviewed. MaxEnt originated in the statistical physics of Boltzmann and Gibbs, as a theoretical tool for predicting the equilibrium states of thermal systems. Later, entropy maximization was also applied to matters of information, signal transmission, and image reconstruction. Recently, since the work of Shore and Johnson, MaxEnt has been regarded as a principle that is broader than either physics or information alone. MaxEnt is a procedure that ensures that inferences drawn from stochastic data satisfy basic self-consistency requirements. The different historical justifications for the entropy $S=\ensuremath{-}\ensuremath{\sum}_{i}{p}_{i}\mathrm{log}﻿{p}_{i}$ and its corresponding variational principles are reviewed. As an illustration of the broadening purview of maximum entropy principles, maximum caliber, which is path entropy maximization applied to the trajectories of dynamical systems, is also reviewed. Examples are given in which maximum caliber is used to interpret dynamical fluctuations in biology and on the nanoscale, in single-molecule and few-particle systems such as molecular motors, chemical reactions, biological feedback circuits, and diffusion in microfluidics devices.
ast finite-difference time-domain modeling for arine-subsurface electromagnetic problems rank

In the low-frequency limit, the displacement currents in the Maxwell equations can be neglected. However, for numerical simulations, a small displacement current should be present to achieve numerical stability. This requirement leads to a large range of propagation velocities with high velocities for the high frequencies and low velocities for the low frequencies. As a consequence, the number of time steps may become large. I show that it is possible to transform mathematically the original physical problem to one that has propagation velocities with less frequency dependence. Hence, the number of time steps necessary for a signal to travel a certain distance with the lowest velocity is significantly reduced. A typical example shows a reduction in computational time by a factor of 40. A comparison of the solutions from plane-layered modeling in the frequency and wavenumber domain and the proposed method shows good agreement between the two. The proposed method can also be used for other systems of diffusive equations.
Tilburg University Perceived Organisational Support and Profitability

This paper investigates the impact of perceived organizational support (POS) on performance. We predict that POS will be reciprocated by positive discretionary employee behavior, which in turn has a positive impact on performance. Empirical research on a sample of Dutch construction companies indeed corroborates a positive relationship between POS and performance. Moreover, the POS-performance link is found to be stronger for good performing firms than for bad performing firms, which supports that reciprocity drives the relationship between POS and performance. Tilburg University Room P2211 Warandelaan 2 P.O. Box 90153 5000 LE Tilburg The Netherlands phone:31 13 4662702 fax:31 13 4662892 E-mail:J.J.Graafland@uvt.nl
Chapter 21. Hearing Aid Research Hearing Aid Research Academic and Research Staff Studies and Results I-a. Role of Reduced Audibility

Our long-term goal is to develop improved hearing aids for people suffering from sensorineural hearing impairments and cochlear implants for the deaf. Our efforts are focused on problems resulting from inadequate knowledge of the effects of various transformations of speech signals on speech reception by impaired listeners, specifically on the fundamental limitations on the improvements in speech reception that can be achieved by processing speech. Our aims are
On the Finiteness of the Capacity of Continuous Channels

Evaluating the channel capacity is one of many key problems in information theory. In this work, we derive rather-mild sufficient conditions under which the capacity of continuous channels is finite and achievable. These conditions are derived for generic, memoryless, and possibly nonlinear additive noise channels. The results are based on a novel sufficient condition that guarantees the convergence of differential entropies under point-wise convergence of probability density functions. Perhaps surprisingly, the finiteness of channel capacity holds for the majority of setups, including those where inputs and outputs have possibly infinite second-moments.
AcMNPV Core Gene ac109 Is Required for Budded Virion Transport to the Nucleus and for Occlusion of Viral Progeny

The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac109 core gene has been previously characterized as an essential late gene. Our results showed that budded virions could be detected in supernatants of infected Sf-9 cells, even when ac109 knockout viruses displayed a single-cell infection phenotype. Moreover, confocal microscopy analysis revealed that budded virions can enter the cytoplasm but are unable to enter the cell nucleus. This defect could be repaired by complementing ac109 in trans. In addition, polyhedra of normal size could be detected in Sf-9 nuclei infected with ac109 knockout viruses. However, electron microscopy demonstrated that these occlusion bodies were empty. Altogether, these results indicate that ac109 is required for infectivity of both phenotypes of virus.
Inactivation of STAT 3 by shRNA Suppresses Cell Growth and Migration in EBV-positive Nasopharyngeal Carcinoma Cells

Rationale: Signal transducer and activator of transcription 3 (STAT3) is confirmed to be constitutively activated in many human cancers, and plays an important role in tumorigenesis, and accumulating evidence has shown that STAT3 may play an important role in the development of nasopharyngeal carcinoma. Objective: determination of the STAT3 activation in EBV-positive nasopharyngeal carcinoma cell, and clarifying the role of STAT3 signalling in cell growth and migration using RNA interference (RNAi). Methods: we constructed a short hairpin RNA (shRNA) expression vector specific for STAT3 and detected the expression of STAT3 by RT-PCR and Western blot. The cell cycle and apoptosis was analyzed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltertrazolium bromide (MTT) and Hoechst 33342. Findings: we demonstrated that STAT3 is constitutively activated in EBV-positive nasopharyngeal carcinoma cell lines, and demonstrated that blockade of STAT3 activation induced apoptosis and inhibited migration of EBV-positive nasopharyngeal carcinoma cells. We also analyzed that knockdown of STAT3 can decrease the expression of STAT3-targeted genes including bcl-2, surviving both at mRNA and protein levels. Conclusions: taken together, we suggested that targeting STAT3 signalling using RNAi technique may serve as a novel therapeutic strategy for treatment of EBV-positive nasopharyngeal carcinoma.
Title Security and Experimental Performance Analysis of a Matrix

Oblivious RAM can hide a client’s access pattern from an untrusted storage server. However current ORAM schemes incur a large communication overhead and/or client storage overhead, especially as the server storage size grows. We have proposed a matrix-based ORAM, M-ORAM, that makes the communication overhead independent of the server size. This requires selecting a height of the matrix; we present how to select the height to match the functionality of the well-known Path ORAM. We then given both theoretical models and experimental results that show M-ORAM can achieve a lower communication overhead than Path ORAM, without a significant increase in maximum client storage overhead.
Cooperative work across cultural boundaries in systems design

This paper is concerned with heterogeneity and the notion of boundaries within systems design. It uses case study material to identify sources of heterogeneity and to understand how these are oriented to within the practicalities of design work. A key concept for analysing work practices is the notion of place. The paper analyses the qualities of the places in which design work takes place (regionalisation, neutrality, specificity) and explores in how far these places allow membership in multiple worlds.
Enhancement Techniques in fingerprints as a tool in Dactyloscopy

In this work an application of image enhancement techniques in fingerprints is presented. Digital Image-processing technology was applied to restored fingerprints with non-uniform contrast. These fingerprints corresponded to unidentified persons who were murdered by Military Forces in 1976. In 1997, after a court decision, Human Right Organisations acceded to the microfilms of the Computer Records Division of the Province of Buenos Aires Police, which contained fingerprints and complementary information from these missing people. Unfortunately most of the fingerprints were taken with a reduction ratio of 41x, they were blurred and their spatial definition was not clear. These features made their classification and comparison very difficult. In this paper a combination of spatial, frequency and morphological enhancement techniques used to restore the fingerprints is presented. Filters had to be combined because the results obtained by applying conventional enhancement techniques were not satisfactory. The resulting images show prominent features in fingerprints that cannot be extracted by other enhancement techniques.
Monte Carlo Techniques for Bayesian Statistical Inference – A comparative review

In this article, we summarise Monte Carlo simulation methods commonly used in Bayesian statistical computing. We give descriptions for each algorithm and provide R codes for their implementation via a simple 2-dimensional example. We compare the relative merits of these methods qualitatively by considering their general user-friendliness, and numerically in terms of mean squared error and computational time. We conclude with some general guidelines and recommendations.
Fraction-Score: A New Support Measure for Co-location Pattern Mining

Co-location patterns are well-established on spatial objects with categorical labels, which capture the phenomenon that objects with certain labels are often located in close geographic proximity. Similar to frequent itemsets, co-location patterns are defined based on a support measure which quantifies the popularity (or prevalence) of a pattern candidate (a label set). Quite a few support measures exist for defining co-location patterns and they share an idea of counting the number of instances of a given label set C as its support, where an instance of C is an object set whose objects carry all the labels in C and are located close to one another. Unfortunately, these measures suffer from various weaknesses, e.g., some fail to capture all possible instances while some others overlook the cases when multiple instances overlap. In this paper, we propose a new measure called Fraction-Score whose idea is to count instances fractionally if they overlap. Compared to existing measures, Fraction-Score not only captures all possible instances, but also handles the cases where instances overlap appropriately (so that the supports defined are more meaningful and consistent with the desirable anti-monotonicity property). To solve the co-location pattern mining problem based on Fraction-Score, we develop efficient algorithms which are significantly faster than a baseline that adapts the state-of-the-art. We conduct extensive experiments using both real and synthetic datasets, which verified the superiority of Fraction-Score and also the efficiency of our developed algorithms.
Risk of brain metastasis reduced after erlotinib treatment in advanced pulmonary adenocarcinoma patients with sensitive EGFR mutation

Purpose Brain metastasis (BM) is associated with impaired quality of life and increased mortality. The study aimed to compare BM risk after erlotinib administration and chemotherapy in stage IIIB/IV pulmonary adenocarcinoma patients harboring epidermal growth factor receptor (EGFR) mutation. Patients and methods Eligible patients underwent match pair process with matching factors, including age, sex, performance status score, first-line or second-line treatment, first-line chemotherapy regimen (for the second-line treatment subgroup), stage IIIB or IV, and genotypes of EGFR mutation. BM and mortality risk of both groups were recorded and compared. Results In total 129 matched pairs were included for analysis. During a median follow-up of 21.5 months, time to BM risk was longer and incidences of BM within 2 years were lower in patients who received erlotinib than chemotherapy in total population, as well as subgroups of first-line treatment, second-line treatment, stage IIIB, stage IV, exon 19 deletion mutation, and exon 21 L858R mutation. Similar overall survival time and 2-year survival rates were seen in two groups totally or in any subgroup. Multivariate analysis showed that BM was retarded in patients who received erlotinib administration (hazard ratio, 1.695; P=0.001) and in patients who were in stage IIIB (hazard ratio, 1.751; P=0.001). Conclusion Erlotinib administration decreases BM risk in advanced pulmonary adenocarcinoma patients harboring sensitive EGFR mutations.
Adaptation in an Active Services Network

: Active services networks will give to users the flexibility to have access to custom services created by them or third party service providers. The Internet will become much more attractive but also services will turn out to be more versatile. The complexity of such a system is expected to be very high making traditional network management strategies unable to cope with the organization of the whole network. New adaptive techniques must be introduced in order to handle the rapid and many small changes in the network state. Genetic algorithms and biological inspired models seem to make the network adaptive to unpredictable changes. Some simulation results prove that those models are promising for the management of the future networks.