Miracle-dz/UniFAR-FTUs huggingface dataset:
Landing Mechanics between Noninjured Women and Women with Anterior Cruciate Ligament Reconstruction during 2 Jump Tasks

Background Women with anterior cruciate ligament reconstruction have different neuromuscular strategies than noninjured women during functional tasks after ligament reconstruction and rehabilitation. Hypothesis Landing from a jump creates high loads on the knee creating dynamic instability in women with anterior cruciate ligament reconstruction, whereas noninjured women have stable knee landing mechanics. Study Design Controlled laboratory study. Methods Fifteen noninjured women and 13 women with anterior cruciate ligament reconstruction performed 5 trials of a single-legged 40-cm drop jump and 2 trials of a 20-cm up-down hop task. Multivariate analyses of variance were used to compare hip and knee joint kinematics, knee joint moments, ground-reaction forces, and electromyographic findings between the dominant leg in noninjured women and reconstructed leg in women with anterior cruciate ligament reconstruction. Results No statistically significant differences between groups were found for peak hip and knee joint angles for the drop jump task. Statistically significant differences in neuromuscular activity (P = .001) and anterior-posterior knee shear forces (P < .001) were seen in women with anterior cruciate ligament reconstruction compared with noninjured women in the drop jump task. However, no statistically significant differences (P > .05) between groups were found for either peak hip and knee joint angles, peak joint kinetics, or electromyographic findings during the up-down hop task. Conclusion Women with anterior cruciate ligament reconstruction have neuromuscular strategies that allow them to land from a jump similar to healthy women, but they exhibit joint moments that could predispose them to future injury if they participate in sports that require jumping and landing.
A search for rapid photometric variability in symbiotic binaries

We report on our survey for rapid (time scale of minutes) photometric variability in symbiotic binaries. These binaries are becoming an increasingly important place to study accretion onto white dwarfs since they are candidate Type Ia supernovae progenitors. Unlike in most cataclysmic variables, the white dwarfs in symbiotics typically accrete from a wind, at rates greater than or equal to 10 −9 M⊙ yr −1 . In order to elucidate the differences between symbiotics and other white dwarf accretors, as well as search for magnetism in symbiotic white dwarfs, we have studied 35 symbiotic binaries via differential optical photometry. Included in our sample are all but one of the symbiotics from the lists of Kenyon (1986) and Downes & Keyes (1988) with published V magnitude less than 14 and declination greater than 20 ◦ . Our study is the most comprehensive to date of rapid variability in symbiotic binaries. We have found one magnetic accretor, Z And, previously reported by Sokoloski & Bildsten (1999). In four systems (EG And, BX Mon, CM Aql, and BF Cyg), some evidence for flickering at a low level (roughly 10 mmag) is seen for the first time. These detections are, however, marginal. For 25 systems, we place tight upper limits on both aperiodic variability (flickering) and periodic variability, highlighting a major difference between symbiotics and cataclysmic variables. The remaining five of the objects included in our sample (the 2 recurrent novae RS Oph and T CrB, plus CH Cyg, o Ceti, and MWC 560) had previous detections of optical flickering. We discuss our extensive observations of these previously-known flickering systems in a separate paper. Five new variable stars were discovered serendipitously in the fields of the survey objects, and the observations of these stars are also presented elsewhere. We discuss the impact of our results on the “standard” picture of wind-fed accretion, and speculate on the possibility that light from quasi-steady nuclear burning on the surface of the white dwarf hides the fluctuating emission from accretion.
The sparse fourier transform : theory & practice

The Fourier transform is one of the most fundamental tools for computing the frequency representation of signals. It plays a central role in signal processing, communications, audio and video compression, medical imaging, genomics, astronomy, as well as many other areas. Because of its widespread use, fast algorithms for computing the Fourier transform can benefit a large number of applications. The fastest algorithm for computing the Fourier transform is the FFT (Fast Fourier Transform) which runs in near-linear time making it an indispensable tool for many applications. However, today, the runtime of the FFT algorithm is no longer fast enough especially for big data problems where each dataset can be few terabytes. Hence, faster algorithms that run in sublinear time, i.e., do not even sample all the data points, have become necessary. This thesis addresses the above problem by developing the Sparse Fourier Transform algorithms and building practical systems that use these algorithms to solve key problems in six different applications. Specifically, on the theory front, the thesis introduces the Sparse Fourier Transform algorithms: a family of sublinear time algorithms for computing the Fourier transform faster than FFT. The Sparse Fourier Transform is based on the insight that many real-world signals are sparse, i.e., most of the frequencies have negligible contribution to the overall signal. Exploiting this sparsity, the thesis introduces several new algorithms which encompass two main axes: * Runtime Complexity: The thesis presents nearly optimal Sparse Fourier Transform algorithms that are faster than FFT and have the lowest runtime complexity known to date. " Sampling Complexity: The thesis presents Sparse Fourier Transform algorithms with optimal sampling complexity in the average case and the same nearly optimal runtime complexity. These algorithms use the minimum number of input data samples and hence, reduce acquisition cost and I/O overhead. On the systems front, the thesis develops software and hardware architectures for leveraging the Sparse Fourier Transform to address practical problems in applied fields. Our systems customize the theoretical algorithms to capture the structure of sparsity in each application, and hence maximize the resulting gains. We prototype all of our systems and evaluate them in accordance with the standard's of each application domain. The following list gives an overview of the systems presented in this thesis. " Wireless Networks: The thesis demonstrates how to use the Sparse Fourier Transform to build a wireless receiver that captures GHz-wide signals without sampling at the Nyquist rate. Hence, it enables wideband spectrum sensing and acquisition using cheap commodity hardware. * Mobile Systems: The thesis uses the Sparse Fourier Transform to design a GPS receiver that both reduces the delay to find the location and decreases the power consumption by 2 x. " Computer Graphics: Light fields enable new virtual reality and computational photography applications like interactive…
Application of fuzzy decision making in mobile robot navigation in dynamic environments

This paper presents a modified sensor-based online method for mobile robot navigation generating paths in dynamic environments. The intelligent part of the algorithm is a Fuzzy Decision Maker (FDM) which enables the robot to do both the guidance-based tracking algorithm and the obstacle avoidance simultaneously. The output of FDM is a weighted combination of velocity vectors generated by velocity obstacle algorithm and guidance based tracking algorithm. The results prove that the robot can track a moving target while maneuvering safely in dynamic environment and avoids stationary and moving obstacles.
Control strategy for the multilevel cascaded H-bridge converter

The control system for Cascaded H-bridge (CHB) converter is proposed in this paper. The converter output voltage is controlled using a Space-Vector Pulse Width Modulation (SV-PWM). The DC-link voltages are controlled by appropriate choice of H-Bridges, used to output voltage generation. The simulation researches of two multilevel CHB rectifiers are presented. These rectifiers were utilized to coupling of two AC grids. Proposed control strategy allows to good voltage stabilization on the DC-link capacitors.
Intrapopulation nestclusters of maternal mtDNA lineages in the polygynous ant Leptothorax acervorum (Hymenoptera: Formicidae)

Analysis of restriction fragment length polymorphism (RFLP) in mitochondrial DNA (mtDNA) in a population of Leptothorax acervorum demonstrates substantial population substructuring. Digestion with four restriction endonucleases, Haelll, Mbol, Mspl and Rsal, gave six, four, three and two different patterns, respectively. Seven composite haplotypes were obtained from the observed cleavage patterns. Uniform aggregations of nests from the same maternal lineage (i. e. with the same haplotype) were found which suggests that nestfounding by a process of budding‐off is common. Groups of nests seem to actively exclude other haplotypes from establishing nests within their territory. Fstatistics suggests that individuals mate at random within the population.
DEOD: uncovering dominant effects of cancer-driver genes based on a partial covariance selection method

MOTIVATION The generation of a large volume of cancer genomes has allowed us to identify disease-related alterations more accurately, which is expected to enhance our understanding regarding the mechanism of cancer development. With genomic alterations detected, one challenge is to pinpoint cancer-driver genes that cause functional abnormalities. RESULTS Here, we propose a method for uncovering the dominant effects of cancer-driver genes (DEOD) based on a partial covariance selection approach. Inspired by a convex optimization technique, it estimates the dominant effects of candidate cancer-driver genes on the expression level changes of their target genes. It constructs a gene network as a directed-weighted graph by integrating DNA copy numbers, single nucleotide mutations and gene expressions from matched tumor samples, and estimates partial covariances between driver genes and their target genes. Then, a scoring function to measure the cancer-driver score for each gene is applied. To test the performance of DEOD, a novel scheme is designed for simulating conditional multivariate normal variables (targets and free genes) given a group of variables (driver genes). When we applied the DEOD method to both the simulated data and breast cancer data, DEOD successfully uncovered driver variables in the simulation data, and identified well-known oncogenes in breast cancer. In addition, two highly ranked genes by DEOD were related to survival time. The copy number amplifications of MYC (8q24.21) and TRPS1 (8q23.3) were closely related to the survival time with P-values = 0.00246 and 0.00092, respectively. The results demonstrate that DEOD can efficiently uncover cancer-driver genes.
Development of a high repetition rate and high voltage switching power supply with a SiC-JFET for an induction synchrotron

This paper evaluates the capability of a silicon carbide junction field-effect transistor for an induction synchrotron. The device was operated with a repetition rate of 1 MHz, a drain-source voltage of 1 kV, and a drain current of 50 A in burst mode. Based on the results, the feasibility of continuous-mode operation from the point of view of maximum junction temperature is evaluated. If the total thermal resistance is smaller than 0.7 °C/W, the device has potential to be applied in an induction synchrotron.
Wild Animals in Daily Life Short Paper

Humans have historically low engagement with the natural world. Global urbanization has led people to abandon wildlife-rich landscapes. The current lack of connectedness to nature is known as nature-deficit disorder. However, to encourage sustainable relationships between humans and other animals, technology to reconnect is urgently needed. The natural world is in a dire state; we are in the midst of a Sixth Mass Extinction. Here we propose that a novel information system, including a mobile app and privacy tools, could enable reconnection with the natural world. We propose the combination of real-time tracking data from wild animals and humans. Novel wildlife experiences, integrated into people’s daily lives, may increase the connectedness to nature, which serves as a key factor for pro-environmental behavior. Further benefits are identified in education, philanthropy, health, and entertainment. Finally, we utilize an innovative privacy-preserving architecture to shield wildlife data from criminal intent.
Exocytosis of Varicella-Zoster Virus Virions Involves a Convergence of Endosomal and Autophagy Pathways

ABSTRACT Varicella-zoster virus (VZV) is an extremely cell-associated herpesvirus with limited egress of viral particles. The induction of autophagy in VZV-infected monolayers is easily detectable; inhibition of autophagy leads to decreased VZV glycoprotein biosynthesis and diminished viral titers. To explain how autophagic flux could exert a proviral effect on the VZV infectious cycle, we postulated that the VZV exocytosis pathway following secondary envelopment may converge with the autophagy pathway. This hypothesis depended on known similarities between VZV gE and autophagy-related (Atg) Atg9/Atg16L1 trafficking pathways. Investigations were carried out with highly purified fractions of VZV virions. When the virion fraction was tested for the presence of autophagy and endosomal proteins, microtubule-associated protein 1 light chain (MAP1LC3B) and Ras-like GTPase 11 (Rab11) were detected. By two-dimensional (2D) and 3D imaging after immunolabeling, both proteins also colocalized with VZV gE in a proportion of cytoplasmic vesicles. When purified VZV virions were enumerated after immunoelectron microscopy, gold beads were detected on viruses following incubation with antibodies to VZV gE (∼100%), Rab11 (50%), and LC3B (30%). Examination of numerous electron micrographs demonstrated that enveloped virions were housed in single-membraned vesicles; viral particles were not observed in autophagosomes. Taken together, our data suggested that some viral particles after secondary envelopment accumulated in a heterogeneous population of single-membraned vesicular compartments, which were decorated with components from both the endocytic pathway (Rab11) and the autophagy pathway (LC3B). The latter cytoplasmic viral vesicles resembled an amphisome. IMPORTANCE VZV infection leads to increased autophagic flux, while inhibition of autophagy leads to a marked reduction in virus spread. In this investigation of the proviral role of autophagy, we found evidence for an intersection of viral exocytosis and autophagy pathways. Specifically, both LC3-II and Rab11 proteins copurified with some infectious VZV particles. The results suggested that a subpopulation of VZV particles were carried to the cell surface in single-walled vesicles with attributes of an amphisome, an organelle formed from the fusion of an endosome and an autophagosome. Our results also addressed the interpretation of autophagy/xenophagy results with mutated herpes simplex virus lacking its ICP34.5 neurovirulence gene (HSVΔ34.5). The VZV genome lacks an ICP34.5 ortholog, yet we found no evidence of VZV particles housed in a double-membraned autophagosome. In other words, xenophagy, a degradative process documented after infection with HSVΔ34. 5, was not observed in VZV-infected cells.
Motion planning for a robotic system with structured intelligence

This paper deals with a robotic system with structured intelligence. Recently, behavior engineering has been discussed as a new technological discipline. The intelligence of a robot depends on the structure of hardware and software for processing information, that is, the structure determines the potentiality of intelligence. Based on perceptual information, a structured intelligent robot makes action from four levels in parallel. In addition, the robot generates its motion through the interaction with environment and at the same time gradually acquires its skill based on the generated motion. To acquire skill and motion, the robot requires internal and external evaluations at least. Actually, a virus-evolutionary genetic algorithm is applied to motion planning for a redundant manipulator and discuss its effectiveness through computer simulation results.
The Hubbard Quantum Wire

By introducing a boundary condition for the quantum wire, the Hubbard model is solved exactly by means of the Bethe ansatz. The wave function for the bounded state is clearly defined, and the secular equation for the spectrum is exactly obtained. The ground state and low-lying excited states are studied in the thermodynamic limit. The ground-state energy in the strong coupling limit is obtained explicitly, and compared with the results of a periodic boundary condition. [S0031-9007(97)05202-2]
Net Neutrality: A Fast Lane to Understanding the Trade-Offs

The “net neutrality” principle has triggered a heated debate and advocates have proposed policy interventions. In this paper, we provide perspective by framing issues in terms of the positive economic factors at work. We stress the incentives of market participants, and highlight the economic conflicts behind the arguments put forward by the different parties. We also identify several key open questions.
Evaluation of the Placenta in a Stillborn Fetus to Estimate the Time of Death

The authors present a case of a presumably unknown pregnancy, in which the newborn was found dead in the bathroom. The child was considered stillborn and the death due to natural causes. The literature on estimation of the time of fetal death is reviewed. It has been reported that certain placental histological changes are useful in predicting the time of death in stillborn fetuses, but little has been published about their potential role. Furthermore, parameters evaluated by literature in examining the placenta for determining time of fetal demise in cases of stillbirth are not uniform in the few studies that have been published. We emphasize that any attempt to estimate the time of fetal death without an adequate knowledge of placental morphological changes is futile and forensically unjustifiable, and that a comprehensive placental, external, and histological examination of the fetus is still the method of choice to gain a reliable forensic answer.
Chemical suppressors of mlo-mediated powdery mildew resistance

Loss-of-function of barley mildew locus o (Mlo) confers durable broad-spectrum penetration resistance to the barley powdery mildew pathogen, Blumeria graminis f. sp. hordei (Bgh). Given the importance of mlo mutants in agriculture, surprisingly few molecular components have been identified to be required for this type of resistance in barley. With the aim to identify novel cellular factors contributing to mlo-based resistance, we devised a pharmacological inhibitor screen. Of the 41 rationally chosen compounds tested, five caused a partial suppression of mlo resistance in barley, indicated by increased levels of Bgh host cell entry. These chemicals comprise brefeldin A (BFA), 2′,3′-dideoxyadenosine (DDA), 2-deoxy-d-glucose, spermidine, and 1-aminobenzotriazole. Further inhibitor analysis corroborated a key role for both anterograde and retrograde endomembrane trafficking in mlo resistance. In addition, all four ribonucleosides, some ribonucleoside derivatives, two of the five nucleobases (guanine and uracil), some guanine derivatives as well as various polyamines partially suppress mlo resistance in barley via yet unknown mechanisms. Most of the chemicals identified to be effective in partially relieving mlo resistance in barley also to some extent compromised powdery mildew resistance in an Arabidopsis mlo2 mlo6 double mutant. In summary, our study identified novel suppressors of mlo resistance that may serve as valuable probes to unravel further the molecular processes underlying this unusual type of disease resistance.
Fully Differential Difference Amplifier for Low-Noise Applications

In this paper, a fully differential difference amplifier designed in 0.35 μm CMOS technology is presented. The proposed amplifier reaches high dynamic range and low input noise. Comparison of noise performance of the proposed fully differential difference amplifier to an ordinary differential amplifier has been performed. Simulation results prove that the developed amplifier circuit can be advantageously used in applications that require a fully differential signal. In our work, the proposed amplifier has been experimentally employed in the analog front end of the readout interface for a MEMS (Micro-Electro-Mechanical-Systems) capacitive microphone.
Relaxivity and magnetization transfer of white matter lipids at MR imaging: importance of cerebrosides and pH.

PURPOSE To measure the effect of the major lipid components of white matter on the relaxation times and magnetization transfer (MT) of water protons. MATERIALS AND METHODS Multilamellar vesicle (MLV) suspensions of pure phosphatidylcholine (PC) and PC with varying proportions of cholesterol (CHOL), sphingomyelin (SPH), and galactocerebroside (GC) were produced at varying pH. T1, T2, and MT were measured. RESULTS Suspensions consisting of PC with CHOL or SPH caused greater shortening of T1 and T2 and slightly greater MT effects than did PC alone. Suspensions consisting of GC and PC caused the greatest decrease in relaxation times, and the MT effect was two to three times greater than with either CHOL-PC or SPH-PC suspensions. At acidic pH, the relaxation time changes and the MT effects with CHOL-PC, SPH-PC, and GC-PC suspensions were greater than the effects of the same MLVs at physiologic pH. CONCLUSION GC has the strongest effect on relaxivity and MT of all the major white matter lipids. The relaxivity and MT observed with white matter lipids is pH dependent, indicating that chemical exchange of protons likely contributes to relaxivity and MT.
Peripapillary Choroidal Thickness and Choroidal Area in Glaucoma, Ocular Hypertension and Healthy Subjects by SD-OCT

Abstract Background: The exact pathogenesis of open angle glaucoma and ocular hypertension remains unclear. Hemodynamic influences are discussed as potential risk factors and the choroid may play an important role in the pathogenesis of open angle glaucoma or ocular hypertension. The current study investigates peripapillary choroidal thickness and choroidal area in patients with open angle glaucoma, subjects with ocular hypertension and healthy subjects using spectral-domain OCT. It furthermore assesses the association between peripapillary choroidal thickness and age, central corneal thickness, refractive error and intraocular pressure. Patients and Methods: Prospectively recorded data of 213 eyes of 177 open angle glaucoma patients, 73 eyes of 50 subjects with ocular hypertension and 152 eyes of 116 healthy control subjects were analyzed by fitting a linear mixed model including age and disease. Results: Peripapillary choroidal thickness was thinnest in glaucoma patients (125 µm), followed by healthy subjects (127 µm) and ocular hypertensive subjects (135 µm). A marginally significant difference was present between ocular hypertension and glaucoma (p = 0.059). Thickest choroids were found superiorly and thinnest choroids inferiorly. Choroidal area was highest in the supero-nasal and lowest in the infero-temporal sectors. Choroidal thickness decreased with age, no significant correlation was evident between peripapillary choroidal thickness and refractive error or intraocular pressure. Peripapillary choroidal thickness and central corneal thickness are significantly negative correlated in healthy subjects. Conclusions: There is a trend towards thicker choroids in ocular hypertensive subjects compared to healthy subjects or glaucoma patients. Thickest choroids are found superiorly, thinnest inferiorly. Interestingly, choroidal area is thinnest in the temporal-inferior sector, one of the regions where glaucomatous damage tends to start.