Miracle-dz/UniFAR-FTUs huggingface dataset:
Real World Analysis of Rear Seat Occupant Safety in Frontal Crashes

The National Highway Traffic Safety Administration’s (NHTSA) Vehicle Safety Rulemaking and Research Priority Plan 2009 – 2011 describes the projects the agency plans to work on in the rulemaking and research areas in those calendar years. Specific programs identified in the plan included research to improve vehicle safety for rear seat occupants, children, and older people. In support of the priority plan, an analysis of real world crash data was conducted to determine the nature of the crash problem and examine the factors that contribute to rear seat occupant injury, including children and older people. A review of the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) and Crash Injury Research and Engineering Network (CIREN) case data was conducted for restrained rear seat occupants in frontal crashes that sustained an Abbreviated Injury Scale (AIS) 3+ injury in 1998 model year and newer vehicles. For each occupant identified, a review of the accompanying investigation was conducted using a methodology similar to that described by Bean et al. [2009]. The authors were then able to identify occupant and crash characteristics associated with rear seat occupants commonly sustaining serious injuries in frontal crashes. For each occupant, a primary cause of the most severe injury was assigned and injury sources were identified. This review suggests that in the absence of overly severe frontal crash conditions and vulnerabilities due to advanced age, properly belted adults and children in age- and stature-appropriate child restraints are reasonably well-protected in the rear seat, although improvements could be achieved in some cases.
EFFECT OF PYRIDINE AND FORMALDEHYDE ON A MACROPHYTE ( LEMNA MINOR L.) AND A SLUDGE WORM ( TUBIFEX TUBIFEX MÜLLER) IN FRESH WATER MICROCOSMS

Pyridine, a suspected genotoxic and formaldehyde, a potent carcinogen, are present in several industrial wastewater including commercial solvent, resin and pesticide manufacturing industries. The extent of pyridine and formaldehyde toxicity in aquatic organisms is unknown. Therefore, in present study the toxicity of pyridine and formaldehyde were investigated in artificial aquatic ecosystem (microcosm) using two freshwater organisms of different trophic levels i.e. a common duckweed; Lemna minor L. and an oligochaete; Tubifex tubifex Muller. In microcosm, formaldehyde was found to be more toxic to chlorophyll (21 days IC50 = 0.08±0.02 mgL-1), protein (21 days IC50 = 0.15±0.02 mgL-1) and biomass (21 days IC50 = 0.18±0.02 mgL-1) contents of L. minor than pyridine. In addition, pyridine was found growth supportive to L. minor at concentration of 0.1-0.3 mgL-1. Formaldehyde was found more toxic than pyridine for T. tubifex. Lethal concentrations for formaldehyde were 0.08±0.004 (LC10–21 days), 0.2±0.03 (LC25–21 days) and 0.39±0.05 mgL-1 (LC50–21 days). For pyridine, lethal concentrations were 0.85±0.08 (LC10-21 days), 2.14±0.2 (LC25-21days) and 4.27±0.3 mgL-1 (LC5021days). The concentration and time dependent decrease in growth rate, soluble protein and glycogen content was observed. To overcome the stress situation, high-energy requirement of worms lead to protein and glycogen catabolism. The results of present study might be an important consideration while assessing the hazards of materials to aquatic organisms or when deriving water quality criteria for aquatic organisms.
ADLs and dynamic architecture changes

Existing ADLs typically support only static architecture specification and do not provide facilities for the support of dynamically changing architectures. This paper presents a possible solution to this problem: in order to adequately support dynamic architecture changes, ADLs can leverage techniques used in dynamic programming languages. In particular, changes to ADL specifications should be interpreted. To enable interpretation, an ADL should have an architecture construction component that supports explicit and incremental specification of architectural changes, in addition to the traditional architecture description facilities. This will allow software architects to specify the changes to an architecture after it has been built. The paper expands upon the results from an ongoing project -building a development environment for CZstyle architectures. ’
Multifaceted Web Services: An Approach to Secure and Scalable Grid Scheduling

A multifaceted or multi-interface web service is a web service that offers interfaces to clients and to other peer web services. The multifaceted web service uses a generic parameter-based approach developed in this paper to allow for collaboration between web servers. This parametric approach solves security and scalability problems and is found to be applicable in many situations. Such an approach is necessary to permit easy collaboration and secure resource sharing. We describe one instantiation of such an approach in the form of a global grid scheduler for data parallel (or Single Program Multiple Data) programs. This scheduler demonstrates the usefulness of our approach in current business environments where administrative policies are a major factor in scheduling decisions.
Key management for secure multicast communication using secret sharing-based revocation scheme

We present a new secret sharing-based revocation scheme, and apply it into key management for secure multicast communication. The group key is distributed via a broadcast/multicast channel. In our protocol, the member's storage cost is a little constant which is independent of the number of broadcast members. The broadcast size is only relative to the number of evicted members. And most important, the batched re-keying operation in our scheme is as same as the single re-keying operation. Our protocol provides complete forward and backwards security, and can be easily proved an unconditionally secure session key distribution scheme with t-revocation capability.
Contribution of protein, starch, and fat to the apparent ileal digestible energy of corn- and wheat-based broiler diets in response to exogenous xylanase and amylase without or with protease1

The ileal energy contribution of protein, starch, and fat in response to 2 exogenous enzyme combinations was studied in 2 digestibility assays with 21- (experiment 1; 432 birds) and 42-d-old (experiment 2; 288 birds) Ross 308 broiler chickens. A 2 × 2 × 3 factorial arrangement of treatments with 2 base grains (corn or wheat), without or with high fiber ingredients (corn distillers dried grains with solubles and canola meal), and 3 enzyme treatments was implemented. Enzyme treatments, fed from 12 to 21 d or 32 to 42 d, were 1) without enzymes, 2) with xylanase from Trichoderma ressei (2,000 U/kg) and amylase from Bacillus licheniformis (200 U/kg; XA), or 3) with XA plus protease from Bacillus subtilis (4,000 U/kg; XAP). All diets contained Escherichia coli phytase (500 FTU/kg). Apparent ileal digestibility (AID) of protein, starch, and fat, as well as the apparent ileal digestible energy, were determined using titanium dioxide as inert marker. A generalized mixed model was used to test main effects and 2-way interactions at P < 0.05. An enzyme × grain interaction was detected for AID of starch at 21 and 42 d, and AID of fat at 21 d, with greater effects of enzymes in wheat-based compared with corn-based diets, but significant increments due to enzymes compared with controls in both diet types. Apparent ileal digestibility of fat at 42 d increased with enzyme supplementation compared with the control treatments. The XA and XAP treatments gradually (P < 0.05) increased AID of protein at 21 d, but only XAP increased AID of protein compared with the control at 42 d. Compared with the controls, XA increased AID energy by 52 or 87 kcal, and XAP by 104 or 152 kcal/kg of DM at 21 or 42 d, respectively. The caloric contribution of starch, fat, and protein were affected differentially by base grain and the presence of fibrous ingredients at 21 and 42 d of age.
Energy Management in Prosumer Communities: A Coordinated Approach

The introduction of uncontrollable renewable energy is having a positive impact on our health, the climate, and the economy, but it is also pushing the limits of the power system. The main reason for this is that, in any power system, the generation and consumption must match each other at all times. Thus, if we want to further introduce uncontrollable generation, we need a large ability to manage the demand. However, the ability to control the power consumption of existing demand management approaches is limited, and most of these approaches cannot contribute to the introduction of reneweables, because they do not consider distributed uncontrolled consumption and generation in the control. Furthermore, these methods do not allow users to exchange or jointly manage their power generation and consumption. In this context, we propose an augmented energy management model for prosumers (i.e., producer and consumer). This model considers controlled and uncontrolled generation and consumption, as well as the prosumer’s ability (i) to plan the intended power consumption; and (ii) to manage real-time deviations from the intended consumption. We apply this model to the energy management of prosumer communities, by allowing the prosumers to coordinate their power consumption plan, to manage the deviations from the intended consumption, and to help each other by compensating deviations. The proposed approach seeks to enhance the power system, and to enable a prosumer society that takes account social and environmental issues, as well as each prosumer’s quality of life.
Analysis of Probabilistic Combinatorial Optimization Problems in Euclidean Spaces

Probabilistic combinatorial optimization problems are generalized versions of deterministic combinatorial optimization problems with explicit inclusion of probabilistic elements in the problem definitions. Based on the probabilistic traveling salesman problem PTSP and on the probabilistic minimum spanning tree problem PMSTP, the objective of this paper is to give a rigorous treatment of the probabilistic analysis of these problems in the plane. More specifically we present general finite-size bounds and limit theorems for the objective functions of the PTSP and PMSTP. We also discuss the practical implications of these results and indicate some open problems.
The Comfortable Cafeteria Program for Promoting Student Participation and Enjoyment: An Outcome Study

&NA; A mixed‐methods design was used to explore the outcomes of a 6‐wk, occupational therapist–led Comfortable Cafeteria program designed to build cafeteria supervisors' and students' capacity to create a positive mealtime environment so that all students can successfully participate in and enjoy a healthy meal and socialization with peers. Students whose scores were in the low and mid‐range at the outset had statistically significant improvements in pretest–posttest visual analog scale ratings of participation and enjoyment. Cafeteria supervisors demonstrated statistically significant improvements in their perceptions of knowledge and skills to supervise and to encourage healthy eating. Qualitative findings add further insight into the program, suggesting that students learned prosocial values (e.g., being kind, helping others), supervisors actively encouraged positive social interaction, and occupational therapists enjoyed implementing the program and recognized positive supervisor and student changes as a result of integrating services in the cafeteria.
Catenin-Dependent Cadherin Function Drives Divisional Segregation of Spinal Motor Neurons

Motor neurons that control limb movements are organized as a neuronal nucleus in the developing ventral horn of the spinal cord called the lateral motor column. Neuronal migration segregates motor neurons into distinct lateral and medial divisions within the lateral motor column that project axons to dorsal or ventral limb targets, respectively. This migratory phase is followed by an aggregation phase whereby motor neurons within a division that project to the same muscle cluster together. These later phases of motor neuron organization depend on limb-regulated differential cadherin expression within motor neurons. Initially, all motor neurons display the same cadherin expression profile, which coincides with the migratory phase of motor neuron segregation. Here, we show that this early, pan-motor neuron cadherin function drives the divisional segregation of spinal motor neurons in the chicken embryo by controlling motor neuron migration. We manipulated pan-motor neuron cadherin function through dissociation of cadherin binding to their intracellular partners. We found that of the major intracellular transducers of cadherin signaling, γ-catenin and α-catenin predominate in the lateral motor column. In vivo manipulations that uncouple cadherin–catenin binding disrupt divisional segregation via deficits in motor neuron migration. Additionally, reduction of the expression of cadherin-7, a cadherin predominantly expressed in motor neurons only during their migration, also perturbs divisional segregation. Our results show that γ-catenin-dependent cadherin function is required for spinal motor neuron migration and divisional segregation and suggest a prolonged role for cadherin expression in all phases of motor neuron organization.
Direct Phenotypic Analysis of Human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-Restricted Human Recombinant Antibodies1

The advent in recent years of the application of tetrameric arrays of class I peptide-MHC complexes now enables us to detect and study rare populations of Ag-specific CD8+ T cells. However, available methods cannot visualize or determine the number and distribution of these TCR ligands on individual cells nor detect APCs in tissues. In this study, we describe for the first time studies of human class I peptide-MHC ligand presentation. These studies were facilitated by applying novel tools in the form of peptide-specific, HLA-A2-restricted human recombinant Abs directed toward a viral epitope derived from human T cell lymphotropic virus type I. Using a large human Ab phage display library, we isolated a large panel of recombinant Fab Abs that are specific for a particular peptide-MHC class I complex in a peptide-dependent, MHC-restricted manner. We used these Abs to visualize the specific complex on APCs and virus-infected cells by flow cytometry, to quantify the number of, and visualize in situ, a particular complex on the surface of APCs bearing complexes formed by naturally occurring active intracellular processing of the cognate viral Ag. These findings demonstrate our ability to transform the unique fine specificity, but low intrinsic affinity of TCRs into high affinity soluble Ab molecules endowed with a TCR-like specificity toward human viral epitopes. These molecules may prove to be crucial useful tools for studying MHC class I Ag presentation in health and disease as well as for therapeutic purposes in cancer, infectious diseases, and autoimmune disorders.
T‐cadherin modulates hepatocyte functions in vitro

Primary hepatocytes from several different species rapidly lose viability and phenotypic functions on isolation from their native microenvironment of the liver. Stromal cells derived from both within and outside the liver can induce phenotypic functions in primary hepatocytes in vitro; however, the molecular mediators underlying this “coculture effect” have not been fully elucidated. We have previously developed a functional genomic screen utilizing cocultures of hepatocytes and 3T3 fibroblasts to identify such candidate hepatocyte‐function‐inducing molecules. In particular, truncated‐cadherin (T‐cadherin) was identified as a potential molecule of interest in induction of hepatic functions. Here we demonstrate that liver‐specific functions of primary rat hepatocytes are induced on cocultivation with Chinese hamster ovary cells engineered to express T‐cadherin on their surface as compared with wild‐type controls. Additionally, culture of cells on substrata presenting recombinant T‐cadherin protein (acellular presentation) enhanced hepatic functions in both pure hepatocyte cultures and in hepatocyte‐stromal cocultures lacking endogenous T‐cadherin expression. Collectively, these data indicate that both cellular and acellular presentation of T‐cadherin can be used to modulate the hepatocyte phenotype in vitro for tissue engineering applications. Our work suggests potential avenues for investigating the role of T‐cadherin on hepatocellular function in vivo in settings such as embryogenesis and liver pathology. — Khetani, S. R. , Chen, A. A. , Ranscht, B. , Bhatia, S. N. T‐cadherin modulates hepatocyte functions in vitro. FASEB J. 22, 3768–3775 (2008)
Aquaporin and Vascular Diseases

Aquaporins (AQP) are family of water channels found in several epithelial and endothelial cells, whose recent identification has provided insights into water transport in several tissues, including the central nervous system (CNS). Since brain edema continues to be the main cause of death from several CNS diseases, such as stroke, much of the interest in AQPs and their functional contribution to the water balance is due to their possible role in clearing edema water from the brain and in managing hydrocephalus and benign intracranial hypertension, suggesting that they could be targets for future treatments of various brain conditions, particularly vascular diseases. AQPs also seem to be involved in cell migration, and a mechanism of AQP-facilitated cell migration has been proposed where local osmotic gradients created at the tip of the lamellipodium drive water influx, facilitating lamellipodial extension and cell migration. AQP-facilitated cell migration was also detected in tumour cells, suggesting that it may have an important role in tumour angiogenesis and spread, and accounting for AQP expression in many tumour cell types and for correlations found between AQP expression and tumour stage in some tumours.
Quietly sharing the load? The role of school psychologists in enabling teacher resilience

Teacher resilience is associated with positive student outcomes and plays an important role in teacher retention and well-being. School ecologies can enable the resilience of teachers, with prior research illustrating the importance of supportive colleagues, strong leadership, and positive school culture. There is limited research, however, exploring the role of school psychologists in supporting or enabling teacher resilience. Using data from experienced Australian school psychologists and teachers, this exploratory qualitative study examines the role of school psychologists in enabling teacher resilience. Findings show that school psychologists directly and indirectly support teacher resilience, although teachers perceive school psychologists’ main role as work with individual students. Issues pertaining to variations in access and particular roles of school psychologists are discussed. Although further research is needed to clarify and promote the role of school psychologists, this study points to them potentially playing an important role in school ecologies that enable teacher resilience.
Self-organization in Software Design

This paper describes some ideas about possible future research within the area of selforganization. Self-organization can be described as when a system moves from "bad" to "good" organization without explicit pressure from the outside. Self-organizing systems has its closest scientific relatives within AI, AL and CS. The research proposed includes studying strategies for AL, system theories and SOS, vector-orientation of state space, and machine cognition. The applications would include demonstrations of meta-theories, automation, autonomy, intelligence and game programming.
Systematic touch scheme for a humanoid robot to grasp a door knob

This paper deals with the practical problem as to how a humanoid robot opens a door in an office environment. Among the several tasks for the door opening, we focus on the recognition of a door and grasping its knob and propose a systematic touch scheme that combines the visual and touch data to grasp a knob safely and robustly. The visual recognition of a door and its knob is done by feature matching by a feature classifier and a segmentation method with minor assumptions about a knob, respectively. The position of a knob from the visual recognition is refined by the proposed touch scheme where a robot touches a knob several times with a hand equipped with a force-torque sensor. We realize that in the on-line experiment, a robot recognizes a door and its knob, and grasps the knob and partially opens the door.
Individual Palmitoyl Residues Serve Distinct Roles in H-Ras Trafficking, Microlocalization, and Signaling

ABSTRACT H-ras is anchored to the plasma membrane by two palmitoylated cysteine residues, Cys181 and Cys184, operating in concert with a C-terminal S-farnesyl cysteine carboxymethylester. Here we demonstrate that the two palmitates serve distinct biological roles. Monopalmitoylation of Cys181 is required and sufficient for efficient trafficking of H-ras to the plasma membrane, whereas monopalmitoylation of Cys184 does not permit efficient trafficking beyond the Golgi apparatus. However, once at the plasma membrane, monopalmitoylation of Cys184 supports correct GTP-regulated lateral segregation of H-ras between cholesterol-dependent and cholesterol-independent microdomains. In contrast, monopalmitoylation of Cys181 dramatically reverses H-ras lateral segregation, driving GTP-loaded H-ras into cholesterol-dependent microdomains. Intriguingly, the Cys181 monopalmitoylated H-ras anchor emulates the GTP-regulated microdomain interactions of N-ras. These results identify N-ras as the Ras isoform that normally signals from lipid rafts but also reveal that spacing between palmitate and prenyl groups influences anchor interactions with the lipid bilayer. This concept is further supported by the different plasma membrane affinities of the monopalmitoylated anchors: Cys181-palmitate is equivalent to the dually palmitoylated wild-type anchor, whereas Cys184-palmitate is weaker. Thus, membrane affinity of a palmitoylated anchor is a function both of the hydrophobicity of the lipid moieties and their spatial organization. Finally we show that the plasma membrane affinity of monopalmitoylated anchors is absolutely dependent on cholesterol, identifying a new role for cholesterol in promoting interactions with the raft and nonraft plasma membrane.
Transnational Families and the Family Nexus: Perspectives of Indonesian and Filipino Children Left behind by Migrant Parent(s)

As a significant supplier of labour migrants, Southeast Asia presents itself as an important site for the study of children in transnational families who are growing up separated from at least one migrant parent and sometimes cared for by 'other mothers'. Through the often-neglected voices of left-behind children, we investigate the impact of parental migration and the resulting reconfiguration of care arrangements on the subjective well-being of migrants' children in two Southeast Asian countries, Indonesia and the Philippines. We theorise the child's position in the transnational family nexus through the framework of the 'care triangle', representing interactions between three subject groups- 'left-behind' children, non-migrant parents/other carers; and migrant parent(s). Using both quantitative (from 1010 households) and qualitative (from 32 children) data from a study of child health and migrant parents in Southeast Asia, we examine relationships within the caring spaces both of home and of transnational spaces. The interrogation of different dimensions of care reveals the importance of contact with parents (both migrant and nonmigrant) to subjective child well-being, and the diversity of experiences and intimacies among children in the two study countries.