Miracle-dz/UniFAR-FTUs huggingface dataset:
Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia

Meisoindigo, a derivative of Indigo naturalis, has been used in China for chronic myeloid leukemia. In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML). In this study, we explored its mechanisms and potential in AML. NB4, HL-60, and U937 cells and primary AML cells were used to examine its effects and the NOD/SCID animal model was used to evaluate its in vivo activity. Meisoindigo inhibited the growth of leukemic cells by inducing marked apoptosis and moderate cell-cycle arrest at the G0/G1 phase. It down-regulated anti-apoptotic Bcl-2, and up-regulated pro-apoptotic Bak and Bax and cell-cycle related proteins, p21and p27. Furthermore, it induced myeloid differentiation, as demonstrated by morphologic changes, up-regulation of CD11b, and increased nitroblue tetrazolium reduction activity in all cell lines tested. In addition, meisoindigo down-regulated the expression of human telomerase reverse transcriptase and enhanced the cytotoxicity of conventional chemotherapeutic agents, cytarabine and idarubicin. As with the results from cell lines, meisoindigo also induced apoptosis, up-regulated p21 and p27, and down-regulated Bcl-2 in primary AML cells. The in vivo anti-leukemic activity of meisoindigo was also demonstrated by decreased spleen size in a dose-dependent manner. Taking these results together, meisoindigo is a potential agent for AML.
Electricity Case: Economic Cost Estimation Factors for Economic Assessment of Terrorist Attacks

The major economic effects of electric power outages are usually associated with three potential outcomes: the loss of human life and health; business losses; and declines in property value (some of which are encompassed within business losses). This report sets forth economic factors for quantifying the cost of loss of human life and injuries and business losses (including those to critical infrastructure that supports social and economic activity) as a basis for accounting for the economic outcomes of terrorist attacks. Although they have been developed for estimating effects of attacks on electric power, these factors are broadly applicable to other kinds of attacks involving deaths, injury or business loss. A variety of alternative measures and values are presented to enable users flexibility in how they are applied.
Turmeric‐based diet can delay apoptosis without modulating NF‐κB in unilateral ureteral obstruction in rats

The unilateral ureteral obstruction (UUO) model of renal injury in rat is characterized by nuclear factor κB (NF‐κB) activation and tumour necrosis factor α (TNF‐α) production, which induces apoptosis via activation of caspase 8 resulting in cell death. Curcumin, the major component found in turmeric spice, has been reported to provide protection against fibrosis and apoptosis elicited by UUO. This study examined the effects of a turmeric‐based diet (5% w/w) on the apoptotic pathway induced by UUO in rats after 30 days of ligation. Administration of a turmeric‐based diet demonstrated a significant decrease (P < 0.05) in mRNA expression of TNF‐α and caspase 8, but not NF‐κB, expression, which may contribute to the protective role of the turmeric‐based diet. We conclude that a turmeric‐based diet can delay apoptosis without modulating NF‐κB, so as not to sensitize the mesangial cells to the apoptotic stimuli.
Pressure‐Diuresis in Volume‐Expanded Rats Tubular Reabsorption in Superficial and Deep Nephrons

Micropuncture experiments were performed in volume-expanded rats to better define the nephron segments in which changes in renal perfusion pressure inhibit tubular reabsorption. Neural influences on the kidney were eliminated by renal denervation, and plasma levels of vasopressin, aldosterone, cortkosterone, and norepinephrine were maintained at fixed levels by i.v. infusion. Fractional excretion of sodium, chloride, and water increased markedly after renal perfusion pressure was elevated from 110 to 150 mm Hg. Renal blood flow, glomerular filtration rate, and single nephron glomerular filtration rate measured from deep and superficial nephrons were unaltered. Reabsorption of chloride and water in the proximal tubule of superficial nephrons decreased by 10% after renal perfusion pressure was elevated and contributed to the pressure-diuretic response. Changes in renal perfusion pressure also altered the reabsorption of water and chloride in juxtamedullary nephrons. The percentage of the filtered water load reaching the tip of the loop of Henle increased from 19.8 ± 2.9 to 38.1 ± 3.0% after renal perfusion pressure was elevated. Chloride delivery rose from 34.2 ± 4.3 to 65.2 ± 4.8% of the filtered load. These results support the view that alterations in medullary hemodynamks participate in the pressure-natriuretk response by inhibiting tubular reabsorption in the proximal tubule or the thin descending limb of the loop of Henle (or both) of juxtamedullary nephrons.
Regional Wine Tourism: A Plan of Development for Western Australia

Wine tourism is attracting considerable attention in Australia and a number of states have embarked on vigorous wine tourism development programmes to bolster the perceived economic benefits of tourism (Hall, Johnson & Mitchell 2000). This paper simply describes the process by which a wine tourism strategy was prepared for the state of Western Australia (WA). The strategy is one of the first to be prepared and it is hoped that it can be used as an exemplar for others which will no doubt follow. The strategy was prepared in 1999, refined in 2000 and will be released in 2001. Wine and tourism are two Australian success stories (Macionis and Cambourne 2000) and the WA wine tourism strategy charts an exciting future for the development of a synthesis of these two great industries. The outstanding ‘value added’ element of the wine tourism industry fosters job creation, stimulates local businesses, especially in regional areas, and enhances both wine exports and international tourism. The broad ranging industry encompassing a range of industries demands a government approach to its future growth. Such synergy provides an exceptional opportunity for the wine and tourism industries to capitalize on the State s existing wine tourism products as well as the growing demand for wine tourism. The WA strategy was developed in accord with the Australian National Wine Tourism Strategy and covered a range of issues. These include raising the awareness and understanding of the value added benefit of tourism to the wine industry; establishing an industry standard for wine tourism outlets and facilities; increasing the skill level of employees in the wine tourism industry; understanding links between wine, food and the Australian lifestyle; and identifying the impediments to the development of wine tourism in Western Australia. This paper provides an overview of the background, process and outcomes of the draft strategy.
How Credible is E-Word of Mouth Across Digital-Marketing Channels?

ABSTRACT Digital communication encourages individuals and marketers to share information easily and spread electronic word of mouth (e-WOM). Yet, many people may find it difficult to judge message and source credibility. The current study suggested that receivers' judgment of e-WOM messages stems from three key channel properties: social capital, information richness, and interactivity. The authors formulated a conceptual framework and then conducted a survey across five digital channels. Findings indicated that channel managers should design information-enriching tools if they wish to enhance channel credibility. Moreover, the study found that marketers need to distribute e-WOM via diverse and socially unrelated e-WOM sources rather than closely related sources.
Multivariable adaptive dynamic surface control based on norm estimation of unknown parameter matrices

In this article, a novel output-feedback adaptive dynamic surface control scheme is proposed for linear time-invariant multivariable plants based on the norm estimation of unknown parameter matrices. Besides avoiding the explosion of complexity problem in traditional multivariable backstepping design, the proposed scheme has the following features: (1) only one parameter needs to be updated on-line regardless of the plant order and input–output dimension, (2) only the Hurwitz condition is required for the high-frequency gain matrix and (3) the ℒ∞ performance of the tracking error can be guaranteed. It is shown that all signals of the closed-loop system are semi-globally uniformly bounded. Simulation results are given to illustrate the effectiveness of the proposed scheme.
Exploring brand masculine patterns: moving beyond monolithic masculinity

Purpose – This research seeks to explore the nature and the structure of brands' masculine dimensions; to develop a reliable and a valid scale to measure brand masculinity and to explore the different brand masculine patterns. Design/methodology/approach – A series of four studies developed and validated a two-factor, five-item measurement scale for brand masculinity using exploratory and confirmatory factor analyses. Content and face validities; reliability and internal validity; convergent and discriminant validities were established. Generalisability of the two dimensions across the gendering of product categories was assessed. A cluster analysis was used to explore brand masculine patterns. Findings – The results indicate that brand masculinity is a bi-dimensional construct (i.e. “Male chauvinism” and “Heroic” dimensions). A cluster analysis performed on 45 brands revealed four brand masculine patterns: hegemonic, emerging, chivalrous and subaltern. Research limitations/implications – French student s.
Entrepreneurial Success: Differing Perceptions of Entrepreneurs and Venture Capitalists

The recent credit crisis has made it more difficult for entrepreneurs to find funding. It is increasingly important for entrepreneurs to know what is important to venture capitalists (VCs) when they make their funding decisions. The authors interviewed entrepreneurs and VCs to determine the traits these groups perceive as necessary for entrepreneurial success. They find that entrepreneurs cite traits inherent in their nature significantly more than VCs. Additionally, entrepreneurs who do not have previous VC funding experience differ significantly from VCs in identifying important factors for VC funding. In contrast, entrepreneurs with previous VC funding experience do not differ from VCs in identifying important funding decision factors.
The distributed lag between air pollution and daily deaths.

Many studies have reported associations between air pollution and daily deaths. Those studies have not consistently specified the lag between exposure and response, although most have found associations that persisted for more than 1 day. A systematic approach to specifying the lag association would allow better comparison across sites and give insight into the nature of the relation. To examine this question, I fit unconstrained and constrained distributed lag relations to the association between daily deaths of persons 65 years of age and older with PM10 in 10 U.S. cities (New Haven, Birmingham, Pittsburgh, Canton, Detroit, Chicago, Minneapolis, Colorado Springs, Spokane, and Seattle) that had daily monitoring for PM10. After control for temperature, humidity, barometric pressure, day of the week, and seasonal patterns, I found evidence in each city that the effect of a single day's exposure to PM10 was manifested across several days. Averaging over the 10 cities, the overall effect of an increase in exposure of 10 microg/m3 on a single day was a 1.4% increase in deaths (95% confidence intervals (CI) = 1.15-1.68) using a quadratic distributed lag model, and a 1.3% increase (95% CI = 1.04-1.56) using an unconstrained distributed lag model. In contrast, constraining the model to assume the effect all occurs in one day resulted in an estimate of only 0.65% (95% CI = 0.49-0.81), indicating that this constraint leads to a substantial underestimate of effect. Combining the estimated effect at each day's lag across the 10 cities showed that the effect was spread over several days and did not reach zero until 5 days after the exposure. Given the distribution of sensitivities likely in the general population, this result is biologically plausible. I also found a protective effect of barometric pressure in all 10 locations.
HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays.

BACKGROUND The concentration of 25-hydroxyvitamin D [25(OH)D] in serum has been designated the functional indicator of vitamin D (VitD) nutritional status. Unfortunately, variability among 25(OH)D assays limits clinician ability to monitor VitD status, supplementation, and toxicity. METHODS We developed an HPLC method that selectively measures 25-hydroxyvitamin D2 [25(OH)D2] and D3 [25(OH)D3] and compared this assay with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, a competitive protein-binding assay (CPBA) on the Nichols Advantage platform, and an RIA from Diasorin. RESULTS For the new HPLC assay, between-run CVs were 2.6%-4.9% for 25(OH)D3 and 3.2%-13% for 25(OH)D2; recoveries were 95%-102%; and the assay was linear from 5 microg/L to at least 200 microg/L. Comparison data were as follows: for HPLC vs LC-MS/MS, y = 1.01x - 4.82 microg/L (Sy/x = 4.93 microg/L; r = 0.996) for 25(OH)D3, and y = 0.902x - 0.566 microg/L (Sy/x = 2.56 microg/L; r = 0.9965 for 25(OH)D2; for HPLC vs Diasorin RIA, y = 0.709x - 5.86 microg/L (Sy/x = 7.35 microg/L; r = 0.7509); and for HPLC vs Nichols Advantage CPBA, y = 1.00x - 3.60 microg/L (Sy/x = 32.7 microg/L; r = 0.6823). CONCLUSIONS The new HPLC method is reliable, robust, and has advantages compared with the Nichols Advantage CPBA and the Diasorin RIA. The Nichols Advantage CPBA overestimated or underestimated 25(OH)D concentrations predicated on the prevailing metabolite present in patients' sera.
Uncertainty and contingency plans in ERP-controlled manufacturing environments

Purpose – This research aims to determine to what extent uncertainties affected manufacturing enterprises' delivery performance, to analyse the performance of their contingency plans in dealing with uncertainties and to explore what technical and organisational factors affected managers' decisions to implement an uncertainty‐diagnosing model.Design/methodology/approach – The methodology included a literature review, postal questionnaire survey and telephone interviews.Findings – A total of 30 companies responded to the questionnaire, 56 per cent of which thought their systems worked well and 80 per cent reported that material shortages were responsible for tardy delivery performance. Tardy delivery was directly or indirectly caused by poor supplier delivery performance in the opinion of 92 per cent of respondents. Seven companies had developed an uncertainty‐diagnosing model. Not all companies needed to adopt the model.Research limitations/implications – Uncertainty and contingency plans were investigated.
GOVERNMENT POLICY AND INDIAN NATURAL RESOURCE DEVELOPMENT

RESUME Since the middle of the century Indian people have sought to develop many natural resources on reserve land. A series of different federal and provincial regulations covering various kinds of development have hampered Bands in their efforts. Several options are possible for development strategies, all of which have both advantages and disadvantages. The author outlines the regulations and the present state of resource development, and points out some dangers which lie ahead. Depuis le milieu du siècle, les Indiens cherchent à développer les ressources naturelles des terres de leurs réserves. Une série de règlements fédéraux et provinciaux relatifs à certaines formes distinctes de développement, a pourtant entravé les initiatives entreprises par les bandes dans ce domaine. Il existe, à cette fin, plusieurs stratégies possibles pour assurer ce développement, les unes et les autres comportant toutefois avantages et désavantages. L'auteur présente les divers règlements régissant l 'exploitation des ressources naturelles, et décrit l 'état présent du développement de celles-ci, tout en indiquant les dangers toujours å craindre. THE CANADIAN JOURNAL OF NATIVE STUDIES IV, 1(1984): 51-66. 52 JAMES S. FRIDERES
STRATEGIC MARKETING IN EDUCATION SERVICES THE CASE OF A PRIVATE TERTIARY INSTITUTION IN GHANA

Driven by the increasing numbers of higher education services in Ghana, the study sought to examine the marketing orientation and strategic marketing practices applied in tertiary institutions. The convenient sampling method was used to select the case specific institution and 25 management staffs with specialized knowledge were identified and sampled. The findings of the study were mainly reported using descriptive statistics. The research findings indicate that the respondents agreed that the institution is market focused and 96% said a strategic marketing plan exists which it uses. Both long and short term plans are used and a marketing plan drives the institutions’ activities. As to the marketing mix variables application, it was realised that not all 7p’s are used in sync and this has an impact on the institution’s performance. Private tertiary education institutions in Ghana need to re-examine their marketing task if they must survive in this competitive sector.
Multi-objective optimization for a humanoid robot walking on slopes

A multi-objective gait optimization method for a humanoid robot's walking on slopes is proposed in this paper. Firstly, based on SCUT-I humanoid robot and slopes model, the complicated process of walking on slopes is parameterized so that hip and ankle trajectories are planned based on IPM (inverted pendulum model). Secondly, a multi-object optimization method based on walking stability, velocity and energy is proposed to search for the optimal gait parameters that are step, walking cycle, the supporting time of double feet and the height of foot. Finally, SCUT-I robot model is built and simulated by Matlab6.5, which verifies the effectiveness and stability of this multi-objective gait optimization method that makes the robot walk on slopes more stably, quickly and lower energy consumption.
Design analysis of 12S-10P hybrid-excitation flux-switching permanent-magnet machines for hybrid electric vehicle

In recent years, flux switching machine (FSMs) has been developed due to the excitation sources are located in the stator and become as an attractive machine that allowing a simple robust rotor structure while provide high torque density. They can be classified into three categories which is consists of field excitation flux switching machine (FEFSM), permanent magnet flux switching machine (PMFSM), and hybrid excitation flux switching machine (HEFSM). The main flux sources for both FEFSM and PMFSM has only field excitation coil (FEC) and PM, respectively whilst HEFSM combines both PM and FECs. In this research, design and performances of a three phase 12S-10P HEFSM in which the field excitation coil (FEC) located external to the PM are investigated. Initially, procedures for the design of the proposed machine that include parts drawing, materials, condition and properties setting are described. Next, coil arrangement test is analyzed to all armature coil slots to confirm the polarity of each phase. Other than that, the flux interaction analysis is performed to investigate the flux capabilities at various current densities. Finally, torque performances are investigated at various armature and FEC current densities.
Spatial Variability of Heavy Metals in the Soils of Ahwaz Using Geostatistical Methods

Heavy metals pollution and their toxic levels in soils is one of the major problems associated with the environment. Like other large cities, Ahwaz, in Southwest of Iran, is exposed to all kinds of environmental pollutions which pose serious problems for human health. A total of 50 soil samples were taken randomly from the surface soils in Ahwaz and the elements of cadmium and lead were measured. Geostatistic and non geostatistic methods were used to determine the spatial distribution. The probability maps were produced using Geographic Information System methods. On the other hand, the Radial Basis Functions is the best interpolation method for Cd and Pb with absoluteerrorof0.209. About 90percentof study area had more cadmium pollution than standard levels while Pb contamination in about 33 percent of the study area is more than standard levels.
Recruitment and Selection

S. DEEPIKA Student, Under the guidance of Mrs. N. HIMA BINDU Management of Department studies Sridevi Women’s Engineering College Abstract: Better recruitment and selection strategies result in improved organizational outcomes. With reference to this context the research paper was entitled recruitment and selection has been prepared to put a in light on recruitment and selection process. What can from the recommendation in those studies. Finally, the researcher presented a brief summary about the recruitment and selection Process. Studies and article that talk about the topic of employment and selection.
The role of 'public trust in corporations' in CSR strategies which deliver value for both business and society

There has been a long debate in the literature on whether socially responsible activities pursued by firms (or else Corporate Social Responsibility (CSR) activities) can have an impact on the financial performance of the firm (see Margolis and Walsh 2001, 2003; Orlitzky et al 2003). However, “the question remains without a definitive answer” (Barnett, 2007:796). So far, the variability of empirical results suggests the need to examine various contingencies that make Corporate Social Responsibility (CSR) investments pay for some firms but not for others. The goal of this paper is to help move the research on the ‘business case for CSR’, towards better understanding of the contingencies that make CSR investments pay for some firms. In particular, we focus on one institutional level contingency, namely ‘public trust in corporations’. Hence, we examine the role of ‘public trust in corporations’, in affecting the return on CSR investments.
The Impact of Involvement on Key Service Relationships

This paper aims to report a study that focuses on the moderating role of involvement in the relationships between customer contact employees' customer orientation and service quality perceptions and satisfaction. A sample of 869 consumers was drawn from four different service providers, scale measures were validated via confirmatory factor analysis and a conceptual model was tested using non-monotonic moderated regression analysis.Findings indicate that higher levels of involvement lead to greater levels of consumer loyalty and a lower need for scarce marketing resources. Hence, involvement does play a significant moderating role; in most cases the relationships are stronger for consumers with higher involvement. This implies that relative to customers with low levels of involvement, managers must be sure to motivate their employees to work with customers to help solve their problems and thus enhance the level of involvement. Conversely, for highly involved customers, contact employees must be aware that they may not play as significant a role in the overall purchase experience as the consumer feels they (the consumer) are an “expert” relative to the products offered. In such cases, customer-oriented employees' role is to be willing to play a supporting and less important role in a customer's purchase decision.