Miracle-dz/UniFAR-FTUs huggingface dataset:
Interleukin‐2 Receptor‐Directed Immunosuppressive Therapies: Antibody‐ or Cytokine‐Based Targeting Molecules

The ideal immunosuppressive therapy can be realized by breaking the lock and key arrangement leading to T-cell activation that intimately engages cellularly bound antigens with those T cells bearing receptors that stereosj>ecificaUy recognize the stimulating antigen. This approach would leave untouched the overwhelming majority of immune cells involved in protective host defense mechanisms, thereby avoiding the undesirable consequences of generalized immunosuppression. This solution would be obtained by developing antibodies or tolerogenic peptides that react with the antigen combining site of T-cell antigen receptors for disease-stimulating antigens. This strategy has been deterred, at least temporarily, by the vast genetic diversity of the T-cel! receptor for antigen. Many reagents would be required to execute clone-specific immunosuppressive therapy. This approach will not provide a practical therapeutic solution unless autoreactive Tcell clones are oligoclonal and similar in each patient with a given disease. We have developed the simpler approach of targeting the high-affinity interleukin-2 receptor (IL-2R). In essence, only recently activated lymphocytes, especially T cells, bear this structure. This structure is absent from the surface of resting T cells and non-lymphoid tissues (Smith 1987). The de novo acquisition of high-afTinity IL-2Rs is a critical event in the course of T-cell activation (Smith 1987. Cantrell & Smith 1984, Leonard et al. 1982, Maddock et ai. 1985). Interac-
Consumer Actual Purchase Behavior for Organic Products In Aceh, Indonesia

Organic products are products that are currently the main choice for consumers who care about their health. In addition, organic products also reduce the impact of environmental damage and are healthier than conventional products. However, in some previous studies that examined the model of attitudes and intentions in behavior of the organic product consumption has shown there are no consistent results yet. The aim of this study was to gain insight into consumers’ purchase behavior, to determine the influence of health concern, environmental concern, product quality and knowledge on attitude, purchase intention and how that can effect an actual purchase behavior of consumers’ toward organic product in Aceh. This study was conducted on 310 consumers that consume organic product in Aceh. The sample were taken using purposive sampling technique and the sample data were statistically analyzed using Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM). The result shows that attitude and purchase intention was significantly affected by health concern, product quality and knowledge but not by environmental concern. Then, attitude was have a significant direct effect on purchase intention, and this significant result has an impact on actual purchase behavior, in which attitude and purchase intention significantly affected actual purchase behavior of consumers’ toward organic product. Keywords—Product Quality; Knowledge; Attitude; Purchase Intention; Actual Purchase Behavior
Anatomy of the ventral nucleus of the lateral lemniscus in rats: A nucleus with a concentric laminar organization

The lateral lemniscus contains relay nuclei of the auditory pathway in which the neurons have been grouped into dorsal and ventral (VNLL) nuclei. The data about the cytoarchitecture of the VNLL are controversial and no agreement exists concerning its tonotopical organization. In this paper, the cytoarchitecture of VNLL and the spatial distribution of its neurons projecting to the central nucleus of the inferior colliculus (CNIC) have been studied by using different tracers.
Predicting the Performance of Small Aquaculture Businesses in Kelantan through Marketing and Logistics Practices

Business performance at production level would influence the overall performance of the aquaculture industry. Many factors can be associated with business performance. It has been argued that a good marketing and logistics practice would lead to a positive business performance. However, it may not be always true for all types of industry, setting and condition. This study examined the effects of marketing and logistics on small business performance in the Kelantanese aquaculture industry. Using a self-administered questionnaire, data were collected from 216 respondents in small aquaculture in Kelantan. The Partial Least Squares Analysis (PLS) was employed to examine the relationship between the marketing, logistics and business performance variables. It was found that only one of the four marketing variables, i.e. place, explained the variation in business performance. But, it had a wrong sign that was negative, instead of a positive sign. On the contrary, two out of three logistics variables (transportation and order processing) influenced the changes in business performance. In the condition of excess demand, marketing did not work, whereas logistics was more important. Thus, a good practice in logistics is more important than that of marketing for small aquaculture businesses.
Synoptic-scale variations in the polar air-mass transformed over the japan sea

The present report studies synoptic-scale variations of the polar air-mass transformed over the Japan Sea, during the “East Japan Sea Observation” in the winters of 1976 and 1977. Rawinsonde observation data at a research vessel are used, in addition to data at operational upper observation stations and the objective analysis data.The multi-layer structure of the transformed air-mass, including the unstable lowest layer and the mixed layer capped by the stable layer, is formed in the transformed airmass over the Japan Sea. The mixed layer, which includes the sub-cloud layer and the cloud layer, is characterized by nearly venically-uniform equivalent potential temperature. The height of the mixed layer top is 1000-1500 m, on the average, over the Japan Sea. The height increases toward the south, and reaches 2000-2500 m over the coastal area of Japan.The height of the mixed layer top, and the apparent total heat source in the transformed air-mass, vary widely in association with the synoptic-scale changes of polar-air outbreak. The height of the mixed layer top tends to increase in association with the increase of the apparent total heat source in the mixed layer, and the decrease of the vertical stability in the lower-middle troposphere. The snowfall depth over the coastal area of Japan tends to increase in association with the increase of the apparent total heat source over the Japan Sea. The important synoptic conditions for the occurrence of the heavy snowfalls are the intense polar-air outbreak, andlor the passage of the cold vortex or the deep cold trough over the Japan Sea.
Evaluation of a novel metal-organic framework as an adsorbent for the extraction of multiclass pesticides from coconut palm (Cocos nucifera L.): An analytical approach using matrix solid-phase dispersion and liquid chromatography.

We report the synthesis, characterization, and application of [Zn(1,4-benzenedicarboxylate)(H2 O)2 ]n , Zn(1,4-benzenedicarboxylate)0.99 (NH2 -1,4-benzenedicarboxylate)0.01 (H2 O)2 ]n , [Zn(1,4-benzenedicarboxylate)0.95 (NH2 -1,4-benzenedicarboxylate)0.05 (H2 O)2 ]n , and [Zn(1,4-benzenedicarboxylate)0.9 (NH2 -1,4-benzenedicarboxylate)0.1 (H2 O)2 ]n as sorbents for the extraction of multiclass pesticides from coconut palm. Liquid chromatography with ultraviolet diode array detection was used as the analysis technique, and the experiments were performed at one fortification level (0.1 μg/g). The recoveries were 47-67, 51-70, 58-72, and 64-76% for [Zn(1,4-benzenedicarboxylate)(H2 O)2 ]n , Zn(1,4-benzenedicarboxylate)0.99 (NH2 -1,4-benzenedicarboxylate)0.01 (H2 O)2 ]n , [Zn(1,4-benzenedicarboxylate)0.95 (NH2 -1,4-benzenedicarboxylate)0.05 (H2 O)2 ]n , and [Zn(1,4-benzenelate)0.95 (NH2 -1,4-benzenedicarboxylate)0.05 (H2 O)2 ]n , and [Zn(1,4-benzenedicarboxylate)0.9 (NH2 -1,4-benzenedicarboxylate)0.1 (H2 O)2 ]n , respectively, with relative standard deviation ranging from 1 to 7% (n = 3). Detection and quantification limits were 0.01-0.05 and 0.05-0.2 μg/g, respectively, for the different pesticides studied. The method developed was linear over the range tested (0.01-10.0 μg/g) with r2 > 0.9991. A direct comparison of [Zn(1,4-benzenedicarboxylate)0.9 (NH2 -1,4-benzenedicarboxylate)0.1 (H2 O)2 ]n with the commercially available neutral alumina showed that [Zn(1,4-benzenedicarboxylate)0.9 (NH2 -1,4-benzenedicarboxylate)0.1 (H2 O)2 ]n was a similar extracting phase for the pesticides investigated.
Automatic Text Annotation for Questions

An automatic annotation method for annotating text with semantic labels is proposed for question answering systems. The approach first extracts the keywords from a given question. Semantic label selection module is then employed to select the semantic labels to tag keywords. In order to distinguish multi-senses and assigns best semantic labels, a Bayesian based method is used by referring to historically annotated questions. If there is no appropriate label, WordNet is then employed to obtain candidate labels by calculating the similarity between each keyword in the question and the concept list in our predefined Tagger Ontology. Experiments on 6 categories show that this annotation method achieves the precision of 76% in average.
Evaluation of the Influence of Principal’s Training on Security Management in Public Secondary Schools in Nzaui Sub-County, Makueni County, Kenya

Many of the secondary schools have had threats to safety from within originating from fires, insect bites, loose and sharp objects, poorly constructed buildings inadequate and poorly ventilated rooms all these among others makes the learner, the teacher and the workers insecure while in school. The study aimed at assessing the influence of the principal’s training on safety management in all the public schools in Nzaui sub-County, Makueni County Kenya. A mixed method was used consequently applying the concurrent triangulation strategy. Qualitative data was thematically examined beside the research objects then presented in description forms. It was evident from the findings that insecurity was on the rise in many secondary schools in Nzaui Sub-county. It further revealed that principals’ training has not been operative in security management in public secondary schools. Thus, the study commends that the principals should develop training mechanism to promote security management in their school. The principals should allocate sufficient resources for employment and training of security staff and purchases of advanced security installations.
Protective effect of Aloe Vera Leaves Extract on Hepatic Tissue Injury in Streptozotocin-induced Diabetic Rats

The negative impact of diabetes on the liver is well recognized. This study was designed to evaluate the hepatoprotective properties of Aloe vera (Aloe barbadensis Miller) leaves extract in streptozotocin-induced diabetes in rats. Male Wistar rats were made diabetic with a single injection of STZ (65 mg/kg i.p.). Rats were randomly allocated into four groups, 10 animals each: Group 1, healthy control rats; Group 2 non-diabetic rats treated with 50 mg/kg b.w. /day i.p. injection of Aloe vera extract; Group 3, diabetic rats; Group 4, diabetic rats treated with the extract (50 mg/kg b.w./day, i.p.) for 8 weeks. Finally, serum AST, ALT, ALP and albumin levels as well as liver MDA, GSH contents and activities of GSH-Px, SOD and CAT were measured to assess hepatic injury. Liver MDA content and serum ALT, AST, AP and bilirubin levels in Groups 3 were found to be significantly increased as compared to Group 1 (P<0.05) and these parameters in Group 4 were significantly decreased as compared to Group 3 (P<0.05). Liver GSH, SOD, CAT and GSH-Px contents and serum albumin level in Group 3 was significantly decreased as compared to Group 1 (P<0.05) and were found to be significantly increased in Group 4 as compared to Groups 3 (P<0.05). Histopathological changes were in agreement with biochemical findings. This study showed that Aloe vera extract have hepatoprotective effects in experimentally induced diabetic rats.
Impact of corporate social responsibility strategies on consumer patronage of telecommunication industry: an MTN experience in Enugu state

The purpose of this study is to investigate the impact of corporate social responsibility (CSR) strategies on consumer patronage of telecommunication industry: an MTNF Science and Technology State. It specifically aims to determine the influence of MTNF Science and Technology Scholarship Scheme as a CSR strategy on consumer patronage of MTN and also, to assess the influence of MTN Foundation Restructured Schools Connect Project as a CSR strategy on the corporate image of MTN. The survey research method was chosen for the study. The study population comprises subscribers of MTN in Enugu State, which is 1,295.918. A sample size of 400 was determined using Taro Yamane’s formula. Applying the simple linear regression, the findings revealed that MTNF Science and Technology Scholarship Scheme as a CSR strategy has a significant influence on consumer patronage of MTN (r = 0.945; t = 56.377; F = 3173.334; p &lt; 0.05). Similarly, it was revealed that there is significant influence of MTN Foundation Restructured Schools Connect Project as a CSR strategy on corporate image of MTN (r = 0.978; t = 92.313; F = 8521.649; p &lt; 0.05). Consequently, the study concludes that CSR is an effective marketing strategy for acquiring customer patronage and generating goodwill and good corporate image. Therefore, MTN should consolidate on executing and improving on CSR projects. This is highly significant as improved CSR will ensure improved customer patronage and boost good corporate image for MTN.
SIRCIT: a system for AT&T overseas network planning

A software system developed by AT&T to do an optimal routing of its international circuits over the worldwide cable and satellite network is described. The planning environment is discussed, and the overall architecture is described. The formulation of the models and their capabilities are summarized. Results generated by this system are used in the planning of international circuit loadings and construction of international facilities. The system does optimal routing of circuits for international message telecommunications service between United States and foreign switches; it also routes custom-services circuits between customer premises. The system takes into account the satellite-loading agreement between COMSAT and AT&T. <<ETX>>
Bondholder Wealth Effects in Joint Ventures and Strategic Alliances Around the World

This paper examines foreign bondholder wealth effects in international collaborations in the form of joint ventures and strategic alliances. Based on a sample of 1,875 Joint venture and strategic alliance event-firm observations from 2009 to 2015, we find positive and significant abnormal returns for bondholders. The average three-month abnormal return is 0.191% for bondholders and 0.354% for stockholders. We focus on the wealth effects for the bondholders and find that country level governance and national culture are dominant drivers of bondholder gain. Results of various robustness tests and subsample analyses confirm the main findings. Additionally, we find little evidence for a wealth transfer between stockholders and bondholders of the foreign participants.
Processing Architecture for High Count Rate Spectrometry with NaI(Tl) Detector

In this paper, implementation of the high count rate gamma-ray spectrometric system with Nal(Tl) detector is presented. The system supports count rates up to 4.2-10 pulses/s. The main focus of the paper is on implementation of algorithms for detection and correction of a pileup effect that is common at high count rates. The system is implemented on an FPGA platform and it is tested and verified using 228Th in presence of 137Cs. Experimental results show that the system is capable of reducing pileup effects and improving resolution of the energy spectrum.
Multi-agent based framework for e-government

This paper presents an architecture framework with underlying technologies that are appropriate to design and deploy efficient government services. Service-oriented architecture driven by intelligent multi-agent components is proposed as a solution to achieve governments' goals of citizens focused efficiency, responsiveness and anticipation. Services are clustered into grapes of services related to specific government domains. Citizens have access through a single multichannel entry point and via service grapes to any service provided by a ministry or a public agency. The results of this research enable governments to be aware of innovative technologies that can assist them in better serving their citizens.
Throughput improvement for power line communication by adaptive MAC protocol

In a multi-user power line communication (PLC) home network, there are several methods to decide who has the right to use the channel to send data. Basically, there are two kinds of scheduling schemes: coordinated and contention-based. For coordinated scheduling scheme, the manager of PLC network, called domain master, will arrange available medium for users according to network resources and users' requirements. The other scheduling scheme, called contention-based, is that users contend for the medium in a transmission opportunity (TXOP) and the user who wins the contention can transmit a data frame or a data frame sequence. In this paper, we propose an adaptive MAC protocol by adjusting data rate and contention window size based on users' defer situations and channel conditions to improve the system throughput. We provide a theorem to show the limit of throughput achievable by the proposed system and perform extensive simulation to verify that the proposed MAC protocol can indeed improve the system throughput by 45% in PLC home networks.
Research on the Influence Mechanism of Organizational Communication Quality on Job Performance of the Post-90s Employees:The Mediating Effect of Job Satisfaction

Based on the post-90s employees in China, this paper takes job satisfaction as a mediator, using empirical analysis to explore the relationship among organizational communication quality, job satisfaction and job performance. The results show that organizational communication quality of the post-90s employees has a significant positive effect on job performance, and job satisfaction plays a comprehensive mediating role in the relationship between the two. The conclusions are of great significance for the post-90s employees to improve their job satisfaction and performance. Keywords—Post-90s employees; Organizational communication quality; Job satisfaction; Job performance
Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Hirsch et al. performed a functional RNAi screen and identified components of the SAGA histone acetyltransferase complex, in particular Gcn5, as critical regulators of reprogramming initiation. In mouse pluripotent stem cells, Gcn5 strongly associates with Myc, and, upon initiation of somatic reprogramming, Gcn5 and Myc form a positive feed-forward loop that activates a distinct alternative splicing network and the early acquisition of pluripotency-associated splicing events.
An Investigation Into the Effect of Electrode Placement of Transcutaneous Electrical Nerve Stimulation (TENS) on Experimentally Induced Ischemic Pain in Healthy Human Participants

IntroductionIt is claimed that transcutaneous electrical nerve stimulation (TENS) operates via a segmental mechanism by reducing ongoing transmission and sensitization of nociceptive dorsal horn neurons. Hence, TENS electrodes are usually placed at the site of pain. ObjectiveThis study compared TENS administered at the site of experimentally induced ischemic pain (ipsilateral forearm) with TENS administered at a location not related to pain (contralateral lower leg). MethodsTen healthy, pain free volunteers took part in a cross-over study during which ischemic pain was induced in the nondominant arm using a modified version of submaximal effort tourniquet technique. Pain intensity was taken at 1-minute interval/s for 5 minutes while receiving TENS either at the ipsilateral arm or contralateral leg. ResultsThere were no statistically significant differences in pain intensity or McGill Pain Questionnaire ratings between TENS given at the arm compared with the leg. DiscussionTaken at face value, the findings suggest that TENS effects were nonspecific and that electrode location does not affect outcome. However, this study should be seen as a call for further research rather than a definitive conclusion.
High levels of hippocampal cholinergic neurostimulating peptide (HDNP> in the CSF of some patients with Alzhemer's disease

Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from the hippocampus of young rats, enhances the cholinergic development of rat medial septal nuclei in vitro. This report concerns the determination of the HCNP content of the cerebrospinal fluid (CSF) of 173 clinically, and of 22 clinico‐pathologically defined patients. A radiommunossay was used throughout. The HCNP level was relatively uniform among the clinically defind patients for almost all non‐Alzheimer's patients, the level fell within the range delimited by ± 2 SD of the mean of all patients taken together, and none of them had a level above this range. By contrast, the early‐onset Alzheimer's diseas patients could be divided on the basis of their HCNP level into two groups, one with high levels (markedly above the mean ± 2 SD range), and the other with levels similar to those of the other patients. The analysis of the CSF samples obtained postmortem revealed that Group I Alzheimer‐type dementia (ATD) patients with clinico‐pathologically established diagnoses had a strikingly higher level of HCNP than patients with either Group II ATD or cerebral vascular diseas. These results suggest that HCNP is involved in certain pathophysiological alterations associated with dementia, and that its determination may be useful in patient evaluation.
A Data Mining Approach to Generating Network Attack Graph for Intrusion Prediction

A network attack graph provides a global view of all possible sequences of exploits which an intruder may use to penetrate a system. Attack graphs can be generated by model checking techniques or intrusion alert correlation. In this paper we proposed a data mining approach to generating attack graphs. Through association rule mining, the algorithm generates multi-step attack patterns from historical intrusion alerts which comprise the attack graphs. The algorithm also calculates the predictability of each attack scenario in the attack graph which represents the probability for the corresponding attack scenario to be the precursor of future attacks. Then the real-time intrusion alerts can be correlated to attack scenarios and ranked by the predictability scores. The ranking result can help identify the appropriate evidence for intrusion prediction from a large volume of raw intrusion alerts. The approach is validated by DARPA 2000 and DARPA 1999 intrusion detection evaluation datasets.