Miracle-dz/UniFAR-FTUs huggingface dataset:
Structured sparse canonical correlation analysis for brain imaging genetics: an improved GraphNet method

MOTIVATION Structured sparse canonical correlation analysis (SCCA) models have been used to identify imaging genetic associations. These models either use group lasso or graph-guided fused lasso to conduct feature selection and feature grouping simultaneously. The group lasso based methods require prior knowledge to define the groups, which limits the capability when prior knowledge is incomplete or unavailable. The graph-guided methods overcome this drawback by using the sample correlation to define the constraint. However, they are sensitive to the sign of the sample correlation, which could introduce undesirable bias if the sign is wrongly estimated. RESULTS We introduce a novel SCCA model with a new penalty, and develop an efficient optimization algorithm. Our method has a strong upper bound for the grouping effect for both positively and negatively correlated features. We show that our method performs better than or equally to three competing SCCA models on both synthetic and real data. In particular, our method identifies stronger canonical correlations and better canonical loading patterns, showing its promise for revealing interesting imaging genetic associations. AVAILABILITY AND IMPLEMENTATION The Matlab code and sample data are freely available at http://www.iu.edu/∼shenlab/tools/angscca/ CONTACT shenli@iu.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Content analysis in SCM research: past uses and future research opportunities

Purpose Content analysis is a methodology that has been used in many academic disciplines as a means to extract quantitative measures from textual information. The purpose of this paper is to document the use of content analysis in the supply chain literature. The authors also discuss opportunities for future research. Design/methodology/approach The authors conduct a literature review of 13 leading supply chain journals to assess the state of the content analysis-based literature and identify opportunities for future research. Additionally, the authors provide a general schema for and illustration of the use of content analysis. Findings The findings suggest that content analysis for quantitative studies and hypothesis testing purposes has rarely been used in the supply chain discipline. The research also suggests that in order to fully realize the potential of content analysis, future content analysis research should conduct more hypothesis testing, employ diverse data sets, utilize state-of-the-art content analysis software programs, and leverage multi-method research designs. Originality/value The current research synthesizes the use of content analysis methods in the supply chain domain and promotes the need to capitalize on the advantages offered by this research methodology. The paper also presents several topics for future research that can benefit from the content analysis method.
Fc&ggr;RIIIa (CD16) Induction on Human T Lymphocytes and CD16pos T-Lymphocyte Amplification

During serial assays designed to amplify natural killer (NK) cells in vitro, we observed that when peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus positive (HIV+) patients were stimulated for 2 weeks with an Epstein-Barr virus-infected B lymphoblastic cell line and interleukin-2, a well known procedure to amplify NK cells in vitro, 44.4±18% CD3+CD16pos T lymphocytes were recovered together with NK cells, of which 78.2% expressed an &agr;&bgr; T-cell receptor (TCR). To identify the T-cell compartment from which they originated (naive, antigen experienced, CD16pos, or CD16neg), we first compared the results obtained with HIV+ patients' PBMCs (where essentially all CD8 cells are antigen experienced) with those obtained from cord blood lymphocytes (essentially naive) and PBMC from healthy donors (with variable antigen experience). Two weeks after stimulation, &agr;&bgr; TCR CD16pos T lymphocytes increased from 0.3%, 2.2%, and 8.2% to 2.5%, 7.7%, and 36.3%, for cord blood, healthy donors, and HIV+ patients, respectively. Second, using cell-sorting experiments for CD16neg cells and antibody-dependent cellular cytotoxicity assays, we demonstrated that a functional CD16 receptor could also be induced at the cell surface of &agr;&bgr; TCR CD16pos T lymphocytes. Together, these results demonstrate that under stimulation conditions known to induce NK cell proliferation, a subset of &agr;&bgr; TCR CD16pos T cells arises from antigen-experienced CD16pos cells but also from antigen-experienced CD16neg T lymphocytes, revealing the possibility to increase a patient's antibody-dependent cellular cytotoxicity potential through simple stimulation of this particular memory compartment.
An association study between the norepinephrine transporter gene and depression

A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
Compact Design of Low Power Standard Ternary Inverter Based on OFF-State Current Mechanism Using Nano-CMOS Technology

We propose a novel standard ternary inverter (STI) based on nanoscale CMOS technology for a compact design of multivalued logic. Using the gate bias independent OFF-state mechanisms of junction band-to-band tunneling (BTBT), tristate STI operation has been demonstrated in the conventional binary CMOS inverter by TCAD device and mixed-mode circuit simulation with 32-nm high-κ/metal-gate technology. Through analytical device modeling on BTBT and subthreshold current, static noise margin (SNM), off-leakage variation (OLV), and operation voltage (VDD) scaling limits of STI have been investigated. The typical SNM is 200 mV and the variability of the intermediate level (ΔVOM~ 50 mV) from OLV can be allowable into the worst SNM (>100 mV) of STI operation at VDD = 1 V. Exponentially reduced BTBT off-leakage around minimum VDD ~ 0.1 V is promising for ultimate low-power application of our STI.
A User-Friendly Shopping Street

The primary concern of this paper is to identify the relationship between attributes under physical qualities and activities that contribute to the user-friendly street. Exploratory Factor Analysis (EFA) is used in the early stages to gather information about the interrelationships among variables. The Cronbach’s Alpha (α) value was used to determine the level of reliability through the internal consistency for each factor. The result for the validity of all construct achieved Alpha (α) value exceeding 0.70. This research found that there are positive correlation between safety with comfort and convenience, safety with accessibility, and accessibility with comfort and convenience.Keywords: Urban shopping, street, physical quality, street activities, user-friendlyeISSN 2398-4279 © 2018. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Corneal collagen cross-linking with riboflavin and ultraviolet-A light for keratoconus: Results in Indian eyes

Aim To assess the results of corneal collagen cross-linking with riboflavin using ultraviolet-A light for keratoconus at one year in Indian eyes. Materials and Methods Sixty-eight eyes of 41 patients with progressive keratoconus were included in this retrospective study. All eyes completed was 12 months of follow-up and 37 eyes had a one-year follow-up. The maximum follow-up was 16 months. Ocular examinations including refraction, best corrected visual acuity (BCVA), corneal topography, were recorded at each visit. Results The mean age was 16.9 ± 3.5 years (range 12-39 years) and the mean follow-up was 10.05 ± 3.55 months (range six to 16 months). Thirty seven eyes with a follow-up of at least 12 months were analyzed. The preoperative values on the day of treatment were compared with postoperative values of the 12-month examination. This showed that BCVA improved at least one line in 54% (20/37) of eyes and remained stable in 28% (10/37) of eyes (P=0.006). Astigmatism decreased by a mean of 1.20 diopter (D) in 47% (17/37) of eyes (P=0.005) and remained stable (within ± 0.50 D) in 42% (15/37) of eyes. The K value of the apex decreased by a mean of 2.73 D in 66% (24/37) of eyes (P=0.004) and remained stable (within ± 0.50 D) in 22% (8/37) of eyes. The maximum K value decreased by a mean of 2.47 D in 54% (20/37) of eyes (P=0.004) and remained stable (within ± 0.50 D) in 38% (14/37) of eyes. Corneal Wavefront analysis revealed that spherical and higher-order aberrations did not show significant variations in the follow-up period. The coma component showed a very significant reduction at six months after treatment and persisted throughout the follow-up period (P=0.003) Conclusion The results show a stabilization and improvement in keratoconus after collagen cross-linking in Indian eyes. This suggests that it is an effective treatment for progressive keratoconus.
Essays on the effects of investor protection and financial structure on firm decisions and outcomes

The laws and financial structure of a country can affect firm decisions and outcomes by affecting financial constraints and agency problems. Power theories of credit suggest that the legal rights of creditors, such as the ability to grab collateral in bankruptcy, increase the willingness of lenders to extend credit. Shareholder protection can reduce information asymmetry and agency problems by mandating quality disclosures, stipulating approval procedures for potentially conflicted transactions and facilitating the private litigation process. The bank-based financial structure can reduce moral hazard by alleviating the free-rider problem in monitoring. This dissertation contains various novel results. The first essay presents evidence of an inverse relation between creditor rights and the value of cash. This is consistent with financial constraints increasing the marginal value of cash, and creditor rights alleviating financial constraints. The second essay suggests that the bank-based financial structure improves the operating performance of large investments especially for diffusely held firms, consistent with the less prevalent freerider problem in monitoring. The third essay shows that shareholder protection raises investment hazard for the smallest firms. This is consistent with the notion that shareholder protection alleviates those asymmetric information-related problems that delay investment, such as cash flow diversion by corporate insiders. In addition to contributing to the scientific literature, the results of this dissertation can have practical implications for companies, suppliers of finance and policymakers. A value-maximizing company should take into account its legal environment when deciding on cash holdings. Suppliers of finance should consider the interplay between financial structure and ownership structure when evaluating the profitability of investments. Policymakers often encourage investments due to their effect on employment and tax income. The results of this dissertation show that investor protection increases the frequency of large investments and their profitability.
Proactive fault-tolerant IGBT-based power converters for mission critical applications in MW range

Mission Critical Application is a general term for any system whose loss could cause downtime in crucial operations for a company. Given the importance assumed by power converters in many critical systems, this research is conducted in the framework of the reliability engineering applied to a well-established medium voltage power converter in the industry environment. Condition monitoring techniques are used to detect changes in parameters of the IGBT power modules aiming to detect die and package degradation during operation. The main goal is anticipate degradation failures in power modules in such a way that the power converter can be reconfigured before a fatal fault. This fully proactive approach prevents the uncertainty related to different failure modes of power semiconductor devices. The premature detection of failure event allows a better equipment availability management.
Effect of Fluoxetine on Inflammatory Cytokines in Drug-Naive Major Depression: A Short-Term Prospective Study from South India

including dose reduction of the SSRI, switch to other antidepressant class, or augmentation with a prodopaminergic compound. The syndrome was associated with a significantly worse prognosis and poorer overall outcome, as demonstrated by a lower level of functioning (measured through the global assessment of functioning scale, P < 0.05), a higher level of disability (measured through the Sheehan disability scale, P < 0.05), reduced quality of life and wellbeing, and, ultimately, overall reduced symptom improvement (measured through the clinical global impression scale, P < 0.05) compared with other patients. Selective serotonin reuptake inhibitor–related apathy might be more frequent in patients with OCD compared with other disorders, in light of the characteristics of the pharmacological treatment impacting serotonergic-dopaminergic systems at different levels. Nevertheless, an alternative hypothesis for patients receiving polytherapies might be represented by the drug interaction between SSRIs and antipsychotic compounds, which might have enhanced the adverse effects of the antipsychotics, resulting in apathy and affective flattening of these patients. Such an alternative explanation could also account for the improvement of apathy symptoms when the pharmacological regimen was changed. Our report suggests that SSRI apathy syndromemay not be a rare event in patients having OCD, and, in light of its association with an overall worse outcome, clinicians should assess and monitor for the onset of this syndrome.
Sensory gating impairment in development of post‐concussive symptoms in mild head injury

Abstract Post‐concussive symptoms reported by mild head injury (MHI) patients have been inadequately understood. Post‐concussive symptoms reported by patients with MHI have so far been explained in terms of impairment in neurocognitive functions or deficits in modulation of flow of information. There are no studies that have looked into sensory gating impairment in MHI and its relation to post‐concussive symptoms. The purpose of the present paper was to investigate the role of sensory gating impairment in post‐concussive symptoms in mild head injury patients. Thirty MHI patients were evaluated for their neuropsychological functions, sensory gating deficits, and post‐concussive symptoms. Neuropsychological functions were in the domain of attention, executive functions, and learning and memory. Sensory gating was assessed by Structured Interview for Assessing Perceptual Anomalies and post‐concussive symptoms were assessed using the Neurobehavioral Rating Scale. Multiple regression method was used to identify predictors for post‐concussive symptoms. Post‐concussive symptoms were predicted by sensory gating deficits when sensory gating deficit was one of the predictors along with neuropsychological functions. Post‐concussive symptoms were predicted by scores of Digit Vigilance and Digit Symbol Substitution Test, when predictors were restricted to neuropsychological functions. Sensory gating deficits were correlated with performance on Digit Symbol Substitution test. Post‐concussive symptoms reported by MHI patients are the result of poor modulation of incoming sensory information.
A Case Studies of Intelligent Buildings in Malaysia

Nowadays, the rapid changes of information and communication technology (ICT) has dominant the way we conduct our business and has also influenced our daily life styles such as attitudes, expectations and behaviours. The demand on ICT facilities in buildings has also increased dramatically to accommodate such lifestyles. Observing this phenomenon, the brand of ‘intelligent building’ (IB) or ‘smart building’ has become a popular trend as building owners attempt to accommodate their building design with modern life style characteristics. In Malaysia, numerous intelligent buildings have been built over the years since the Multimedia Super Corridor (MSC) was introduced by the government in 1996. To date, there is lack of documenting intelligent building implementation in Malaysia . Therefore, this paper aims to presents the documentation of intelligent building implementation in Malaysia that focus on three prominent buildings in Klang Valley, Malaysia. The ‘Best -Practices Guide for Evaluating Intelligent Building Technologies’ provided by the Cont inental Automated Buildings Association (CABA) was used as an evaluation tools. It is anticipated that this paper will provide an initial indication and guidelines on how Iintelligent is being implemented in Malaysia.
Signal detection technique for asynchronous filtered multi-tone modulation-based mesh systems

In this study, the authors propose a signal detection technique of successive interference cancellation to reduce the effect of inter-symbol interference (ISI), which is caused by the time difference of arrivals among distributed nodes in an asynchronous wireless mesh network based on filtered multi-tone modulation. The proposed signal detection technique uses partial matrices of a transmission gain matrix to mitigate the ISI effect from the adjacent symbols. Under the assumption of perfect symbol time offset and channel estimation at each node, it is shown by simulation that the proposed technique can improve the bit error rate performance with lower complexity compared with the conventional technique.
Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness.

INTRODUCTION There is now evidence that major depression is accompanied by an induction of inflammatory and oxidative and nitrosative stress (IO&NS) pathways and by a lowered antioxidant status. Coenzyme Q10 (CoQ10) is a strong antioxidant that has anti-inflammatory effects. METHODS This paper examines the plasma concentrations of CoQ10 in 35 depressed patients and 22 normal volunteers and the relationships between plasma CoQ10 and treatment resistant depression (TRD), the severity of illness as measured by means of the Hamilton Depression Rating Scale (HDRS) and the presence of chronic fatigue syndrome (CFS). RESULTS We found that plasma CoQ10 was significantly (p=0.0002) lower in depressed patients than in normal controls. 51.4% of the depressed patients had plasma CoQ10 values that were lower than the lowest plasma CoQ10 value detected in the controls. Plasma CoQ10 was significantly lower in patients with TRD and with CFS than in the other depressed patients. There were no significant correlations between plasma CoQ10 and the HDRS. DISCUSSION The results show that lower CoQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression. It is suggested that depressed patients may benefit from CoQ10 supplementation. The findings that lower CoQ10 is a risk factor to coronary artery disease and chronic heart failure (CHF) and mortality due to CHF suggest that low CoQ10 is another factor explaining the risk to cardiovascular disorder in depression. Since statins significantly lower plasma CoQ10, depressed patients and in particular those with TRD and CFS represent populations at risk to statin treatment.
Coherent THz Phonons Driven by Light Pulses and the Sb Problem: What is the Mechanism?

G. A. Garrett,1,2 T. F. Albrecht,1,2 J. F. Whitaker,1 and R. Merlin1,2,3 1Center for Ultrafast Optical Science, The University of Michigan, Ann Arbor, Michigan 48109-2099 2The Harrison M. Randall Laboratory of Physics, The University of Michigan, Ann Arbor, Michigan 48109-1120 3Department of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (Received 23 July 1996)
Molecular Differentiation of Renibacterium salmoninarum Isolates from Worldwide Locations

ABSTRACT Renibacterium salmoninarum is a genospecies that is an obligate pathogen of salmonid fish and is capable of intracellular survival. Conventional typing systems have failed to differentiate isolates of R. salmoninarum. We used two methods to assess the extent of molecular variation which was present in isolates from different geographic locations. In one analysis we investigated possible polymorphisms in a specific region of the genome, the intergenic spacer (ITS) region between the 16S and 23S rRNA genes. In the other analysis we analyzed differences throughout the genome by using randomly amplified polymorphic DNA (RAPD). We amplified the spacer region of 74 isolates by using PCR and performed a DNA sequence analysis with 14 geographically distinct samples. The results showed that the 16S-23S ribosomal DNA spacer region of R. salmoninarum is highly conserved and suggested that only a single copy of the rRNA operon is present in this slowly growing pathogen. DNA sequencing of the spacer region showed that it was the same length in all 14 isolates examined, and the same nucleotide sequence, sequevar 1, was obtained for 11 of these isolates. Two other sequevars were found. No tRNA genes were found. We found that RAPD analysis allows reproducible differentiation between isolates of R. salmoninarum obtained from different hosts and different geographic regions. By using RAPD analysis it was possible to differentiate between isolates with identical ITS sequences.
Antecedents and Consequences of Brand Image: A Case of a Packaged Drinking Water Product

Problem in this research was the importance of examining the positive effect of independent variables on brand image and the positive effect of brand image on the dependent variable. This research used hypothesis testing methodology. The data was obtained from questionnaire of which the number of variables was 10 items, the number of indicators was 41 items, and the number of respondents selected was 200 people. This empirical research used Structural Equation Modeling (SEM) for the data analysis. The findings in this research were: (1) there was positive influence of brand awareness, excitement, and perceived quality toward the AQUA brand image as a Packaged Drinking Water product, and (2) there was positive influence of the AQUA brand image as Packaged Drinking Water product toward brand trust, brand loyalty, brand love, and word of mouth (WOM).