Miracle-dz/UniFAR-FTUs huggingface dataset:
Sparse convolutional coding for neuronal assembly detection

Cell assemblies, originally proposed by Donald Hebb (1949), are subsets of neurons firing in a temporally coordinated way that gives rise to repeated motifs supposed to underly neural representations and information processing. Although Hebb's original proposal dates back many decades, the detection of assemblies and their role in coding is still an open and current research topic, partly because simultaneous recordings from large populations of neurons became feasible only relatively recently. Most current and easy-to-apply computational techniques focus on the identification of strictly synchronously spiking neurons. In this paper we propose a new algorithm, based on sparse convolutional coding, for detecting recurrent motifs of arbitrary structure up to a given length. Testing of our algorithm on synthetically generated datasets shows that it outperforms established methods and accurately identifies the temporal structure of embedded assemblies, even when these contain overlapping neurons or when strong background noise is present. Moreover, exploratory analysis of experimental datasets from hippocampal slices and cortical neuron cultures have provided promising results.
Dealer spread and portfolio selection under price risks: evidence from the gold service industry

The bid and ask quotes as well as portfolio selection decisions of gold dealers who face a gold price risk are investigated within a continuous-time framework. The research integrates into a systematic analysis the decision of asset allocation in financial economics as well as the decision of a bid–ask spread in a market microstructure. The holding rate of gold is correlated to the intensity and jump size of the Poisson process, which is a hedging demand for gold assets against the risk of extreme events. According to empirical analysis from the gold service industries, the gold spread return is related to the expected return, volatility and jump risks of gold prices.
A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission in C. elegans

Synaptic vesicles (SV) store various neurotransmitters that are released at the synapse. The molecular mechanisms of biogenesis, exocytosis, and endocytosis for SV, however, remain largely elusive. In this study, using Complex Object Parametric Analysis and Sorter (COPAS) to monitor the fluorescence of synapto-pHluorin (SpH), we performed a whole-genome RNAi screen in C. elegans to identify novel genetic modulators in SV cycling. One hundred seventy six genes that up-regulating SpH fluorescence and 96 genes that down-regulating SpH fluorescence were identified after multi-round screen. Among these genes, B0035.1 (bugz-1) encodes ortholog of mammalian C2H2 zinc-finger protein BuGZ/ZNF207, which is a spindle assembly checkpoint protein essential for mitosis in human cells. Combining electrophysiology, imaging and behavioral assays, we reveal that depletion of BuGZ-1 results in defects in locomotion. We further demonstrate that BuGZ-1 promotes SV recycling by regulating the expression levels of endocytosis-related genes such as rab11.1. Therefore, we have identified a bunch of potential genetic modulators in SV cycling, and revealed an unexpected role of BuGZ-1 in regulating synaptic transmission.
A Bio-Inspired Hybrid Thermal Management Approach for 3-D Network-on-Chip Systems

3-D network-on-chip (NoC) systems are getting popular among the integrated circuit (IC) manufacturer because of reduced latency, heterogeneous integration of technologies on a single chip, high yield, and consumption of less interconnecting power. However, the addition of functional units in the $z$ -direction has resulted in higher on-chip temperature and appearance of local hotspots on the die. The increase in temperature degrades the performance, lifetime, and reliability, and increases the maintenance cost of 3-D ICs. To keep the heat within an acceptable limit, floorplanning is the widely accepted solution. Proper arrangement of functional units across different layers can lead to uniform thermal distribution in the chip. For systems with high density of elements, few hotspots cannot be eliminated in the floorplanning approach. To overcome, liquid microchannel cooling technology has emerged as an efficient and scalable solution for 3-D NoC. In this paper, we propose a novel hybrid algorithm combining both floorplanning, and liquid microchannel placement to alleviate the hotspots in high-density systems. A mathematical model is proposed to deal with heat transfer due to diffusion and convention. The proposed approach is independent of topology. Three different topologies: 3-D stacked homogeneous mesh architecture, 3-D stacked heterogeneous mesh architecture, and 3-D stacked ciliated mesh architecture are considered to check the effectiveness of the proposed algorithm in hotspot reduction. A thermal comparison is made with and without the proposed thermal management approach for the above architectures considered. It is observed that there is a significant reduction in on-chip temperature when the proposed thermal management approach is applied
A PATH‐ANALYTIC MODEL FOR THE MEASUREMENT OF SELECTION ON MORPHOLOGY

This paper describes a path model for the analysis of phenotypic selection upon continuous morphological characters. The path‐analysis model assumes that selection occurs on unmeasured general size and shape allometry factors that summarize linear relations among sets of ontogenetically, phylogenetically, or functionally related traits. An unmeasured factor for general size is considered the only aspect of morphometric covariance matrices for which there is an a priori biological explanation. Consequently, selection coefficients are derived for each measured character by holding constant only a general size factor, rather than by using multiple regression to adjust for the full covariance matrix. Fitness is treated as an unmeasured factor with loadings, representing directional selection coefficients, computed as the covariances of the size‐adjusted characters with the measured fitness indicator. The magnitudes and signs of the selection coefficients, combined with biological insight, may suggest hypotheses of selection on one or more shape allometry factors. Hypotheses of selection on general size and shape allometry factors are evaluated through cycles of measurement, analysis, and experimentation, designed to refine the path diagram depicting the covariances among the measured characters, the measured indicator of fitness, and unmeasured factors for morphology and fitness.
Selective Versus Universal Vouchers: Modelling Median Voter Preferences in Education

Under the majority voting rule, a system of universally available vouchers (UV) is politically less feasible than a system of selective vouchers (SV) confined to families with incomes equal to or less than median voter income. After the introduction of UV, public expenditure on education will have to be shared with previous private school users. Per capita expenditure will then drop and/or tax will increase. Since these events will injure the median voter, he will reject UV. He will be indifferent between the status quo and SV. Indifference will turn into enthusiasm however, if, as can be expected, the new regime (SV) brings effective new competition.
Dispersion stabilization of silver nanoparticles in synthetic lung fluid studied under in situ conditions

Abstract The dispersion stabilization of silver nanoparticles (AgNPs) in synthetic lung fluid was studied to interrogate the effects on colloidal stability due to the principal constituents of the fluid. The colloidal stability of 20 nm citrate-AgNPs dispersed in the presence of each constituent of the synthetic lung fluid (individually, the complete fluid, and without additives) was observed during titration of increasing sodium chloride concentration. A variety of complementary in situ measurement techniques were utilized, including dynamic light scattering, ultraviolet-visible absorption spectroscopy, atomic force microscopy, and small-angle X-ray scattering, which provided a collective set of information that enabled far better understanding of the dispersion behavior in the fluid than any one technique alone. It was observed that AgNPs continued to adsorb bovine serum albumin (BSA) protein from the synthetic lung fluid solution as the sodium chloride concentration increased, until a maximum BSA coating was achieved prior to reaching the physiological sodium chloride concentration of 154 mmol L−1. BSA was determined to be the constituent of the synthetic lung fluid that is required to provide colloidal stability at high salt loadings, though the phospholipid constituent exerts a subtle effect. Additionally, as AgNPs are a distinctly different class of nanoparticles apart from the carbon nanotubes and titanium dioxide nanoparticles initially reported to be dispersible using this fluid, this work also demonstrates the broad applicability of synthetic lung fluid in providing stable dispersions for engineered nanoparticles for use in biological assays.
Heart-type fatty acid binding protein is a sensitive biomarker for early AMI detection in troponin negative patients: a pilot study

Abstract Background: Early detecting AMI in individuals presenting to the ED with chest pain continues to be a challenge. cTn is the gold standard for AMI diagnosis but early presenters (<1 hours from symptom onset) maybe cTn negative on admission. We analysed the diagnostic value of h-FABP and hs-TnI in patients presenting to ED with chest pain and no cTnI elevations. Methods: 28 AMI and 28 no-AMI individuals both presented to ED within one hour from pain onset were included. Blood donors were analysed for h-FABP cut-off identification. Among AMI patients, 55% were positive for h-FABP and 34.6% were positive for hs-TnI (p = .015), thus 21% were positive only for h-FABP. The diagnostic accuracy was assessed by ROC curve. h-FABP showed a higher sensitivity but lower specificity than hs-TnI. Conclusions: In our study, the frequency of h-FABP positivity among AMI patients was higher than that of hs-TnI, which would have missed six of them; however, hs-TnI AUC was superior to that of h-FABP. These preliminary findings might confirm that h-FABP may be a good candidate for AMI rule-in/rule-out within the ED context.
Return to driving after head injury

OBJECTIVES To determine whether patients who return to driving after head injury can be considered safe to do so and to compare the patient characteristics of those who return to driving with those who do not. METHODS In a multicentre qualitative study 10 rehabilitation units collectively registered 563 adults with traumatic brain injury during a 2.5 year period. Recruitment to the study varied from immediately after hospital admission to several years after injury. Patients and their families were interviewed around 3 to 6 months after recruitment. A total of 383 (67.5%) subjects were interviewed within 1 year of injury, of whom 270 (47.6%) were interviewed within 6 months of injury. Main outcome measures were the presence or absence of driving related problems reported by drivers and ex-drivers, and scores on driving related items of the functional independence/functional assessment measure (FIM+FAM). RESULTS Of the 563 patients 381 were drivers before the injury and 139 had returned to driving at interview. Many current drivers reported problems with behaviour (anger, aggression, irritability; 67 (48.2%)), memory ( 89 (64%)), concentration and attention (39 (28.1%)), and vision (39 (28.1%)). Drivers reported most driving related problems as often as ex-drivers, main exceptions were epilepsy and community mobility. Current drivers scored significantly higher on the FIM+FAM (were more independent), than ex-drivers. The driving group had sustained less severe head injuries than ex-drivers; nevertheless, 78 (56.2%) current drivers had received a severe head injury. Few (61 (16%)) previous drivers reported receiving formal advice about driving after injury. CONCLUSIONS The existence of problems which could significantly affect driving does not prevent patients returning to driving after traumatic brain injury. Patients should be assessed for both mental and physical status before returning to driving after a head injury, and systems put in place to enable clear and consistent advice to be given to patients about driving.
Estimating and Evaluating Value‐at‐Risk Forecasts Based on Realized Variance: Empirical Evidence from ICE Brent Crude Oil Futures

This paper is the first to use the concept of realized volatility to forecast Value-at-Risk (VaR) for ICE Brent Crude oil futures. We examine sensitivities in the VaR forecasts across intra-daily sampling frequency used to calculate realized volatility. We evaluate the VaR forecasts using Christoffersen's test for conditional coverage on quantiles of particular interest. Additionally, we examine a percentile–percentile plot of the VaR forecasts for all percentiles. The main empirical results show that very good VaR forecasts can be obtained using Gaussian critical values in combination with volatility forecasts based on realized volatility. An examination of the sampling frequency suggests that the most accurate VaR forecasts are obtained with a sampling frequency of between 1 and 10 min. This has important implications for practitioners operating in the financial oil sector.
Inventory Control with Information About Supply Conditions

This paper presents an inventory-control model which includes a Markovian model of the supply system. As that system evolves over time, so do the replenishment leadtimes. The optimal policy has the same structure as in standard models, but its parameters change dynamically to reflect current supply conditions. In this setting, contrary to conventional wisdom, a longer leadtime does not necessarily imply more inventory. The leadtime is important, but so is a concept we call order coverage.
Fiscal sustainability and policy implications: a post-crisis analysis for the euro area

In this paper, we examine the sustainability of euro area public finances against the backdrop of population ageing after the 2008â€“2009 recession. We argue that ageing costs may be higher than projected by the Working Group on Ageing Populations (AWG) of the EU's Economic Policy Committee, consider alternative indicators to quantify sustainability gaps for euro area countries and assess the appropriateness of different budgetary strategies to restore fiscal sustainability taking into account intergenerational equity. Our stylised analysis based upon lifetime contributions to the government's primary balance of different generations suggests that an important pre-funding of ageing costs is necessary to avoid shifting the burden of adjustment in a disproportionate manner to future generations. For many euro area countries this implies that the medium-term targets defined in the context of the revised Stability and Growth Pact would ideally need to be revised upwards to obtain significant surpluses.
Pacific Asia after ‘Asian values’: authoritarianism, democracy, and ‘good governance’

The 1997 Asian economic crisis discredited the international discussion about ‘Asian values’ in Pacific Asia, replacing it with a globalised ‘good governance’ discourse. The financial breakdown undermined claims by Asian autocrats that government should be based on authoritarian ‘Asian values’, not ‘Western democracy’. Yet, seven years later, authoritarian regimes in the region are flourishing while the new democracies flounder. Why have dictatorships, not democracies, prospered politically since the Asian financial crisis? Pacific Asia began as an ‘imagined community’ of developmental dictatorships, making authoritarian development the ‘original position’ against which democratic governance is judged. While the demise of ‘Asian values’ contributed to the fall of the Suharto regime in Indonesia, it did less harm to authoritarian regimes in more economically developed Malaysia and Singapore. The US‐led anti‐terror coalition provided several authoritarian rulers in Pacific Asia with welcome support from the West, while allowing them to weaken internal opposition. The new democracies, by contrast, faced international pressures to combat terrorism, often arousing local protest. Finally, middle class‐based reformist movements have risked destabilising the region's new democracies in the name of good governance.
ETIOLOGY, PROGNOSIS, AND OUTCOME OF POST-OPERATIVE ACUTE RENAL FAILURE

A Multivariate analysis was done in all patients who developed post operative ARF, during the period 1990–1995 to determine the etiological spectrum and to identify various variables affecting the outcome. Of 140 patients (110 operated at SGPGI and 30 operated outside) 116 underwent elective surgery. The different types of surgery leading to ARF were urosurgery (3.5%), open heart surgery (32.9%), gastrosurgery (16.4%), pancreatic surgery (9.3%), obstetrical surgery (3.6%) and others (2.8%). The incidence of ARF in SGPGI patients was highest in pancreatic surgery group (8.2%) followed by open heart surgery (3%). The different etiological factors responsible for ARF were perioperative hypotension (67.1%), sepsis (63.6%) and exposure to nephrotoxic drugs (29.3%). Sixty-four patients (45.7%) required dialysis. The overall mortality was 45% The mortality was highest in patients who underwent open heart surgery (89.1%) followed by pancreatic surgery (84.6%). The factors associated with high mortality, other than the type of surgery, were preoperative hypotension (p <0.05), oliguria (p <0.01), need for dialysis (p <0.05) and multiorgan failure (p <0.001). AM following emergency surgery had poor outcome, though not statistically significant. Perioperative sepsis (p <0.05) and preoperative use of aminoglycoside (p <0.05) were significantly higher in patients operated outside SGPGI. This was associated with higher incidence of ARF. Thus we conclude that presence of multiorgan failure, oligoanuria, preoperative hypotension and need far dialysis are poor prognostic markers in ARF following surgery.
A Chinese New Year Aware ARIMA Model for Electricity Consumption Forecast

The forecast of electricity consumption has a siginificant impact on both economics and society. Various models have been developed to make this forecast accurate. Among them is the highly successful ARIMA model which is based on time series analysis. However, when applied local in China, ARIMA forecast is not as accurate as expected, due to the moving holiday effect of Chinese New Year feastive period. This paper proposes a revised ARIMA model which adjusts its forecast by the use of a China New Year (CNY) coefficient. Preliminary experimental results on real data show that this revised model outperforms the traditional one. Index Terms - consumption forecast, time series, seasonal effect, ARIMA model s s t t t t t d
Proportionality and Turnout

Many studies find that voter turnout is higher in proportional representation (PR) elections than in plurality elections, but because the two systems differ in multiple ways and are used in different contexts it is difficult to know precisely why. I focus on municipal elections in France, where cities above a certain population threshold are required to use a PR system while those below use a type of plurality rule; this setting allows me to compare political outcomes across electoral systems while holding fixed a large set of social and political features. I find that the PR system noticeably increases turnout compared with plurality. I provide evidence suggesting that it does so in part by encouraging turnout in lopsided races and in part by inducing entry of new candidates. The findings highlight the importance of electoral proportionality in explaining cross-national differences in voter turnout.
apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium

In Salmonella typhimurium, the synthesis of the pyrimidine moiety of thiamine can occur by utilization of the first five steps in de novo purine biosynthesis or independently of the pur genes through the alternative pyrimidine biosynthetic, or APB, pathway (D. M. Downs, J. Bacteriol. 174:1515-1521, 1992). We have isolated the first mutations defective in the APB pathway. These mutations define the apbA locus and map at 10.5 min on the S. typhimurium chromosome. We have cloned and sequenced the apbA gene and found it to encode a 32-kDa polypeptide whose sequence predicts an NAD/flavin adenine dinucleotide-binding pocket in the protein. The phenotypes of apbA mutants suggest that, under some conditions, the APB pathway is the sole source of the pyrimidine moiety of thiamine in wild-type S. typhimurium, and furthermore, the pur genetic background of the strain influences whether this pathway can function under aerobic and/or anaerobic growth conditions.
Complete Genome Sequence of Mesorhizobium sophorae ICMP 19535T, a Highly Specific, Nitrogen-Fixing Symbiont of New Zealand Endemic Sophora spp.

ABSTRACT We report here the complete genome sequence of Mesorhizobium sophorae ICMP 19535T. This strain was isolated from Sophora microphylla root nodules and can nodulate and fix nitrogen with this host and also with Sophora prostrata, Sophora longicarinata, and Clianthus puniceus. The genome consists of 8.05 Mb.
Pesticide Risk Valuation in Empirical Economics

Pesticide use in agriculture poses several risks to both human health and non-target agro-ecosystems. Due to lack of information on the monetary value of reducing pesticide risks, it is difficult to perform an economic analysis that addresses social efficiency of policy and draws conclusions about the appropriate degree of regulation.The aim of the current paper is to present a critical overview of the empirical literature on pesticide risk valuation that provides disaggregate willingness-to-pay estimates (WTPs) of pesticide risks reduction. Recent multidimensional classification methods, such as coined decision tree analysis, are used in a comparative approach as tools for explaining the differences in empirical research findings. The analysis shows that the magnitude of WTPs is related to both the valuation technique and to the data available from biomedical and eco-toxicological literature. It also shows that WTP estimates of pesticide risks cannot be simply averaged over several empirical studies. The order of magnitude of a WTP estimate is, in fact, related to the specific type of risk and to the nature of the risk scenario considered, as well to lay people's subjective perception of risks.
Labor Regulation, Corporate Governance, and Legal Origin: A Case of Institutional Complementarity?

We explore the finding of La Porta et al. that differences in Olegal originO account for part of cross-national diversity in labour regulation and corporate governance. We suggest that the finding needs a better historical grounding and that a mechanism which might explain it has not been adequately spelled out. In search of an explanation we focus on the role of complementarities between legal and economic institutions, and in particular the part played by the distinctive Olegal culturesO of the common law and civil law in setting national systems on separate pathways to economic development.