Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring the impact of a public awareness campaign to increase Welfare Power of Attorney registrations in Scotland

Objective to measure the impact of the 'My Power of Attorney' media campaign on the number of new power of attorney (POA) registrations in Scotland. Setting POA registrations in Scotland processed by the Office of the Public Guardian during January 2010 to June 2015. Methods multilevel Poisson models for POA registrations nested by council and annual quarter were run using Markov chain Monte Carlo methods, adjusting for time, campaign (variable ranging between 0 and 5 dependent on intensity of campaign measured by the number of media platforms received) and offset term mid-year population estimate for those aged 25 years+/65 years+. Results POA registrations saw a reduction between 2010 and 2011 but overall, increased between 2010 and 2015. POA registrations rose by 33.3% in Glasgow City between 2013 and 2014, when the campaign began, while the rest of Scotland saw a rise of 17.3%. When the data were modelled, Relative Risk (RR) of a POA registration increased with increasing intensity of campaign, so that in an area in receipt of the full campaign was RR = 1.31 (1.28, 1.34) that of an area with no campaign. Between council variation persisted after adjustment for campaign (Variance = 0.041 (0.011)). Conclusions during the period of the campaign, area-level increases in POA registrations were observed associated with the 'My Power of Attorney' timing and location, in an approximate dose-response relationship with campaign intensity, suggesting that this is likely to be due to the campaign that began in Glasgow City.
Piezo‐electric head application in a new 3D printing design

Purpose – This paper aims to focus on redesigning a 3D printing machine, using piezoelectric demand‐mode technology head in order to improve the factors of accuracy, surface finishing and color quality of fabricated models.Design/methodology/approach – The work first identifies two kinds of ink‐jet printing heads, and then develops a new design of 3D printing machine, based on piezoelectric head technology. Fabricated models by this new 3D printing machine were compared with the same models fabricated by current 3D printing machines (z406). Findings – The comparison between the constructed models by two types of 3D printing machines shows improvement factors of accuracy, surface finishing and color quality using piezoelectric head in the current 3D printing machine.Research limitations/implications – In order to provide a colorful binder, a type of binder such as ZB56 was combined with six different colors of ink namely black, cyan, magenta, yellow, light cyan, and light magenta.Practical implications – Th.
Knowledge, Attitudes and Practices of Mothers in Kosova About Complementary Feeding for Infant and Children 6-24 Months

Aim: This cross sectional study assessed knowledge, attitudes and practices regarding complementary feeding among mothers with children between 6-24 months at the national level. Methods: The sample of 492 mothers with children between 6-24 months, with a confidence level of 95%, the acceptable margin of 5%, the expected prevalence of 50% knowledge and effect of 1.3, were interviewed from all regions, in all Kosovo. Data were analyzed using SPSS version 17.0 and presented using descriptive and inferential statistics such as Chi-square with significance level set at 5%. Results: Overall, 88.4% of respondents had good knowledge of complementary feeding, while only 38.4% of mothers had good practices regarding time for starting complementary feeding. We found association between maternal knowledge and level of education for complementary feeding. Conclusion: There is a need to further explore the factors responsible to improving practices for complementary feeding.
UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis

The ubiquitin‐associated protein 2–like (UBAP2L) gene remains poorly studied in human and mouse development. UBAP2L interacts with the Polycomb group protein B lymphoma Mo‐MLV insertion region 1 homolog (BMI1) and determines the activity of mouse hematopoietic stem cells in vivo. Here we show that loss of Ubap2l leads to disorganized respiratory epithelium of mutant neonates, which die of respiratory failure. We also show that UBAP2L overexpression leads to epithelial‐mesenchymal transition–like phenotype in a non‐small cell lung carcinoma (NSCLC) cell line. UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification. Supporting a possible role for UBAP2L in lung tumor progression, NSCLC cells engineered to express low levels of this gene produce much smaller tumors in vivo than wild‐type control cells. Together, these results suggest that UBAP2L contributes to epithelial lung cell identity in mice and that it plays an important role in human lung adenocarcinoma. —Aucagne, R. , Girard, S. , Mayotte, N. , Lehnertz, B. , Lopes‐Paciencia, S. , Gendron, P., Boucher, G. , Chagraoui, J., Sauvageau, G. UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis. FASEB J. 31, 5012–5018 (2017). www.fasebj. org
Effects of Childhood Gymnastics Program on Spatial Working Memory

Purpose A growing body of evidence has demonstrated the positive effects of physical exercise on cognition in children, and recent studies have specifically investigated the cognitive benefits of exercises involving cognitive–motor interactions, such as gymnastics. This study examined the effect of 8 wk of gymnastics training on behavioral and neurophysiological measures of spatial working memory in children. Methods Forty-four children age 7 to 10 yr were recruited. The experimental group (n = 24; age, 8.7 ± 1.1 yr) was recruited from Yilan County in Taiwan, while the control group (n = 20; age, 8.6 ± 1.1 yr) resided in Taipei City. The experimental group undertook 8 wk of after-school gymnastics training (2 sessions per week, 90 min per session), whereas the control group received no intervention and were instructed to maintain their routine daily activities. Working memory was assessed by performance on a modified delayed match-to-sample test and by event-related potential including the P3 component. Data were collected before and after treatment for the experimental group and at the same time interval for the control group. Results Response accuracy improved after the experimental intervention regardless of working memory demands. Likewise, the P3 amplitude was larger at the parietal site after gymnastics training regardless of the task difficulty. Conclusions Our results suggest that a short period of gymnastics training had a general facilitative effect on spatial working memory at both behavioral and neurophysiological levels in children. These finding highlight the potential importance of exercise programs involving cognitive–motor interactions in stimulating development of spatial cognition during childhood.
Magnetic flux density bias analysis and suppression strategy for voltage‐fed single‐stage full‐bridge converter

Power transformer in the voltage‐fed single‐stage full‐bridge (SSFB) converter is easy to be saturated because of the special operating mode of this topology. First and foremost, detailed analysis about the generation mechanism of the transformer saturation in the voltage‐fed SSFB converter is presented for the first time in this paper. Second, the mathematical expression of the maximum value of magnetic flux density bias (MFDB) during every line cycle is deduced. Furthermore, a novel suppressing strategy, consisted of the digital compensating algorithm and design considerations, is proposed based on the theoretical analysis and mathematical expression. The MFDB can be eliminated and additional circuits are not needed with the proposed strategy. Finally, a 1 kW prototype with the voltage‐fed SSFB topology is built to verify the effect of the proposed approach. The voltage‐second imbalance is reduced to less than 1% using the proposed suppression strategy compared with 14% when the strategy is not used. Consequently, the system reliability and the efficiency are improved. Copyright © 2016 John Wiley & Sons, Ltd.
Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis

The maintenance of the intracellular level of amino acids is crucial for cellular homeostasis. This is carried out via the regulation of both the influx from the extracellular environment and the recycling of intracellular resources. Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. Under AAS culture conditions, the cell killing effect of GEF was synergistically pronounced in the EGFR-expressing cell lines, namely, CAL 27, Detroit 562, A549 and PANC-1 cells compared with those treated with either GEF or AAS alone. The addition of essential amino acids, but not non-essential amino acids to the cell culture medium resulted in the cancellation of this pronounced cytotoxicity. The knockdown of L-type amino acid transporter 1 (LAT-1) by siRNA also enhanced GEF-induced cytotoxicity. Therefore, the shortage of the intracellular amino acid pool appears to determine the sensitivity to GEF. Notably, this enhanced cytotoxicity is not mediated by the induction of apoptosis, but is accompanied by the pronounced induction of autophagy. The presence of necrostatin-1, an inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK-1), but not that of Z-VAD-fmk, attenuated the cytotoxic effects of GEF under AAS culture conditions. Electron microscopy demonstrated that the CAL 27 cells treated with GEF under AAS culture conditions exhibited swelling of the cytosol and organelles with an increased number of autophagosomes and autolysosomes, but without chromatin condensation and nuclear fragmentation. Autophagic cell death was excluded as the inhibition of autophagy did not attenuate the cytotoxicity. These results strongly suggest the induction of necroptosis in response to GEF under AAS culture conditions. However, we could not detect any phosphorylation of RIPK-1 and mixed lineage kinase domain like pseudokinase (MLKL), as well as any necrosome formation. Therefore, the enhanced cytotoxic effect of GEF under AAS culture conditions is thought to be mediated by atypical necroptosis.
Suppression and facilitation of human neural responses

Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining 5 different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: 1) both suppression and facilitation can emerge from a single, computational principle – divisive normalization; there is no need to invoke separate neural mechanisms, 2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and 3) suppression is not driven by GABA-mediated inhibition. Thus, while commonly used spatial suppression paradigms may provide insight into neural response magnitudes in visual areas, they cannot be used to infer neural inhibition.
Attention modeling using inputs from a Brain Computer Interface and user-generated data in Second Life

A model of attention in computer-based assessment exercise in Second Life is presented. Attention is measured considering psychometric inputs based on Electro Encephalogram (EEG) readings using NeuroSky technology. The model of attention considers the readings and combines them with user-generated, performance data [1] (giving-up, answer correctness and time spent) to determine states of attention and trigger strategies to improve or sustain an optimal level of attention. The novelty of this approach is in using NeuroSky technology to read attention levels and in combining this input with user-generated data taken from interaction. This model of attention is based on the ARCS [2,3] model of motivation and can be later integrated into a model of motivation [4] for virtual worlds learning. The paper discusses the feasibility of using attention to complement existing models of motivation [4] and outlines work for the future.
Replication with QoS support for a distributed multimedia system

Replicating data and services at multiple networked computers increases the service availability, fault-tolerance andquality of service (QoS) of distributed multimedia systems. In this paper, we discuss some relevant design and implementation issues of a replication mechanism for a distributed multimedia system medianode[1] which is a software infrastructure to share multimedia-enhanced teaching materials among lecture groups. To identify new replication requirements, we first study the characteristics of presentational media types which are handled in medianode, then extract new replica units and granularities which have not been considered and not supported in existing replication mechanisms. Based on the new requirements and the result of feature surveys, we implemented a replication mechanism for medianode. The next working step is to evaluate the efficiency of our replica maintenance mechanism.
#MyDepressionLooksLike: Examining Public Discourse About Depression on Twitter

Background Social media provides a context for billions of users to connect, express sentiments, and provide in-the-moment status updates. Because Twitter users tend to tweet emotional updates from daily life, the platform provides unique insights into experiences of mental health problems. Depression is not only one of the most prevalent health conditions but also carries a social stigma. Yet, opening up about one’s depression and seeking social support may provide relief from symptoms. Objective The aim of this study was to examine the public discourse of the trending hashtag #MyDepressionLooksLike to look more closely at how users talk about their depressive symptoms on Twitter. Methods We captured 3225 original content tweets for the hashtag #MyDepressionLooksLike that circulated in May of 2016. Eliminating public service announcements, spam, and tweets with links to pictures or videos resulted in a total of 1978 tweets. Using qualitative content analysis, we coded the tweets to detect themes. Results The content analysis revealed seven themes: dysfunctional thoughts, lifestyle challenges, social struggles, hiding behind a mask, apathy and sadness, suicidal thoughts and behaviors, and seeking relief. Conclusions The themes revealed important information about the content of the public messages that people share about depression on Twitter. More research is needed to understand the effects of the hashtag on increasing social support for users and reducing social stigma related to depression.
Predicting long-term survival after coronary artery bypass graft surgery.

OBJECTIVES To develop a model for predicting long-term survival following coronary artery bypass graft surgery. METHODS This study included 46 573 patients from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZCTS) registry, who underwent isolated coronary artery bypass graft surgery between 2001 and 2014. Data were randomly split into development (23 282) and validation (23 291) samples. Cox regression models were fitted separately, using the important preoperative variables, for 4 'time intervals' (31-90 days, 91-365 days, 1-3 years and >3 years), with optimal predictors selected using the bootstrap bagging technique. Model performance was assessed both in validation data and in combined data (development and validation samples). Coefficients of all 4 final models were estimated on the combined data adjusting for hospital-level clustering. RESULTS The Kaplan-Meier mortality rates estimated in the sample were 1.7% at 90 days, 2.8% at 1 year, 4.4% at 2 years and 6.1% at 3 years. Age, peripheral vascular disease, respiratory disease, reduced ejection fraction, renal dysfunction, arrhythmia, diabetes, hypercholesterolaemia, cerebrovascular disease, hypertension, congestive heart failure, steroid use and smoking were included in all 4 models. However, their magnitude of effect varied across the time intervals. Harrell's C-statistics was 0.83, 0.78, 0.75 and 0.74 for 31-90 days, 91-365 days, 1-3 years and >3 years models, respectively. Models showed excellent discrimination and calibration in validation data. CONCLUSIONS Models were developed for predicting long-term survival at 4 time intervals after isolated coronary artery bypass graft surgery. These models can be used in conjunction with the existing 30-day mortality prediction model.
Infrared thermal imaging in medicine

This review describes the features of modern infrared imaging technology and the standardization protocols for thermal imaging in medicine. The technique essentially uses naturally emitted infrared radiation from the skin surface. Recent studies have investigated the influence of equipment and the methods of image recording. The credibility and acceptance of thermal imaging in medicine is subject to critical use of the technology and proper understanding of thermal physiology. Finally, we review established and evolving medical applications for thermal imaging, including inflammatory diseases, complex regional pain syndrome and Raynaud's phenomenon. Recent interest in the potential applications for fever screening is described, and some other areas of medicine where some research papers have included thermal imaging as an assessment modality. In certain applications thermal imaging is shown to provide objective measurement of temperature changes that are clinically significant.
Measurement Bias of Gross Pathologic Compared With Radiologic Tumor Size of Resected Lung Adenocarcinomas: Implications for the T-Stage Revisions in the Eighth Edition of the American Joint Committee on Cancer Staging Manual

Objectives The eighth edition of the AJCC Cancer Staging Manual now stratifies the T descriptor for lung cancers by each increasing 1.0 cm increment, up to 5.0 cm, with an additional category for tumor greater than 7.0 cm. Bias in pathologic versus radiologic measurements may impact tumor staging. Methods The gross pathologic measurements of 493 resected lung adenocarcinomas were compared with presurgical computed tomography radiologic measurements. Also, pathologic tumor measurement data from the Surveillance, Epidemiology, and End Results (SEER) program database were examined. Results The distribution of pathologic measurements showed clustering at 0.5-cm increments, with 43.0% of pathologic measurements falling on 0.5-cm increments compared to only 20.3% of radiologic measurements. This pathologic measurement clustering was also observed for both 591,691 resected lung cancers and 3,597,685 tumors of any type from the SEER database. Conclusions Compared to radiologic measurements, gross pathologic measurements cluster around whole- and half-cm values. This measurement bias could lead to incorrect pathologic tumor staging and influence clinical treatment plans.
General Anesthesia Versus Conscious Sedation for Endovascular Treatment of Acute Ischemic Stroke: The AnStroke Trial (Anesthesia During Stroke)

Background and Purpose— Retrospective studies have found that patients receiving general anesthesia for endovascular treatment in acute ischemic stroke have worse neurological outcome compared with patients receiving conscious sedation. In this prospective randomized single-center study, we investigated the impact of anesthesia technique on neurological outcome in acute ischemic stroke patients. Methods— Ninety patients receiving endovascular treatment for acute ischemic stroke in 2013 to 2016 were included and randomized to general anesthesia or conscious sedation. Difference in neurological outcome at 3 months, measured as modified Rankin Scale score, was analyzed (primary outcome) and early neurological improvement of National Institutes of Health Stroke Scale and cerebral infarction volume. Age, sex, comorbidities, admission National Institutes of Health Stroke Scale score, intraprocedural blood pressure, blood glucose, Paco2 and Pco2 modified Thrombolysis in Cerebral Ischemia score, and relevant time intervals were recorded. Results— In the general anesthesia group 19 of 45 patients (42.2%) and in the conscious sedation group 18 of 45 patients (40.0%) achieved a modified Rankin Scale score ⩽2 (P=1.00) at 3 months, with no differences in intraoperative blood pressure decline from baseline (P=0.57); blood glucose (P=0.94); PaCO2 (P=0.68); time intervals (P=0.78); degree of successful recanalization, 91.1% versus 88.9% (P=1.00); National Institutes of Health Stroke Scale score at 24 hours 8 (3–5) versus 9 (2–15; P=0.60); infarction volume, 20 (10–100) versus 20(10–54) mL (P=0.53); and hospital mortality (13.3% in both groups; P=1.00). Conclusions— In endovascular treatment for acute ischemic stroke, no difference was found between general anesthesia and conscious sedation in neurological outcome 3 months after stroke. Clinical Trial Registration— URL: https://www.clinicaltrials. gov. Unique identifier: NCT01872884.
Ieee Transactions on Information Forensics and Security 1 Blind Authentication Using Periodic Properties of Interpolation

—In this paper we analyze and analytically describe the specific statistical changes brought into the covariance structure of signal by the interpolation process. We show that interpolated signals and their derivatives contain specific detectable periodic properties. Based on this, we propose a blind, efficient and automatic method capable of finding traces of resampling and interpolation. The proposed method can be very useful in many areas, especially in image security and authentication. For instance, when two or more images are spliced together, to create high quality and consistent image forgeries, almost always geometric transformations such as scaling, rotation or skewing are needed. These procedures are typically based on a resampling and interpolation step. By having a method capable of detecting the traces of resampling, we can significantly reduce the successful usage of such forgeries. Among other points, the presented method is also very useful in estimation of the geometric transformations factors.