Miracle-dz/UniFAR-FTUs huggingface dataset:
ISAR Imaging of High-Speed Maneuvering Target Using Gapped Stepped-Frequency Waveform and Compressive Sensing

In the case of a stepped-frequency waveform (SFW) inverse synthetic aperture radar (ISAR) system, the translational motion (TM) of a target can be usually divided into two parts: 1) target motion within a pulse repetition interval, called the inter-pulse translational motion (IPTM) and 2) target motion between bursts, called the inter-burst translational motion (IBTM). The former induces severe blurring in the ISAR images as well as range-compressed data (i.e., range profile), and the latter also causes dramatic degradation of the ISAR image quality. In this paper, a novel framework for high-resolution gapped SFW (GSFW) ISAR imaging of high-speed maneuvering target is proposed. The main novelty of the proposed method is twofold: 1) accurate TM parameter estimation in conjunction with a compressive sensing theory using a newly devised cost function and particle swarm optimization and 2) compensation for both the IPTM and IBTM phase errors simultaneously even with the GSFW data set. Simulation results using ideal point scatterers show that the proposed method is capable of precise reconstruction of ISAR image and accurate TM parameter estimation. Experimental results using real measured data verify the robustness and the effectiveness of the proposed method.
Does exercise reduce brain oxidative stress? A systematic review

The aim of the present systematic review was to investigate the influence of different exercise programs on brain oxidative stress. A search of the literature was conducted up to 1 December 2012 across five databases: PUBMED, SCOPUS, SPORTS DISCUS, Web of Science, and The Cochrane Library. The search strategy used in the electronic databases mentioned was established as: (swim* OR exercise OR training) AND (“oxidative stress” AND brain) for each database. A methodological quality assessment valuation/estimation was additionally carried out in the final sample of studies. Of 1553 potentially eligible papers, 19 were included after inclusion and exclusion criteria. The methodological quality assessment showed a total score in the Quality Index between 40% and 80%, with a mean quality of 56.8%. Overall, regular moderate aerobic exercise appears to promote antioxidant capacity on brain. In contrast, anaerobic or high‐intensity exercise, aerobic‐exhausted exercise, or the combination of both types of training could deteriorate the antioxidant response. Future investigations should be focused on establishing a standardized exercise protocol, depending on the exercise metabolism wanted to test, which could enhance the objective knowledge in this topic.
First novel once-weekly DPP-4 inhibitor, trelagliptin, for the treatment of type 2 diabetes mellitus

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors are weight neutral and well tolerated, and provide better glycaemic control for a longer period compared to conventional therapies. Despite the fact that various drugs are available, glycaemic control remains suboptimal in approximately half of patients with type 2 diabetes mellitus; one of the major reasons for low medication adherence. Areas covered: A novel DPP-4 inhibitor, trelagliptin, was approved in Japan in March 2015, and is the first once-weekly oral antidiabetic agent in the world. In this review, current issues concerning medication adherence for the treatment of diabetes are discussed followed by a summary of the characteristics and future expectations of trelagliptin, by reviewing the recent phase I, II, and III clinical studies of trelagliptin. Expert opinion: Trelagliptin has demonstrated superiority to placebo and non-inferiority to alogliptin, indicating its efficacy and tolerance in Japanese patients. Trelagliptin is expected to improve adherence and prevent complications. Due to the convenient dosing regimen, it is expected to be widely used in the clinical setting. A large-scale long-term study will help further confirm its long-term efficacy and safety, patients’ satisfaction, and medication adherence.
Segmentation and tracking of stem cells in time lapse microscopy to quantify dynamic behavioral changes during spheroid formation

Dynamic behavior of stem cells during in vitro development is diverse. Previous cell tracking studies have focused more on cell proliferation than on cell aggregation. However, the enhancement of cell proliferation in association with cell aggregation has been reported. In a previous study, we also demonstrated that the aggregation of adult human mesenchymal stem cells to form three‐dimensional (3D) cellular spheroids helped maintain the expression of stemness marker genes in the cells. However, the dynamic behavioral changes triggered by spheroid formation remain to be investigated. A scheme of image processing techniques is proposed to meet this need. A hybrid‐thresholding technique was first developed for efficient segmentation of cell clusters, after which a cell tracking method based on pair‐matching with topological constraints was designed. Two morphological indices were derived to track the timing of 3D spheroid formation during the cellular aggregation process. Five cell motility indices measured from single cells and 3D spheroids were then compared. After confirmation of more than 90% correspondence between the results obtained by manual tracking and the proposed methods, an analysis of cellular behavior reveals a significant increase in motility in association with spheroid formation, consistent with a previous report that used a gene expression approach. This study proposed a systematic image analysis method to quantify the dynamic behavior of stem cells for stemness evaluation during cell culturing in vitro. Results demonstrated the validity of the developed platform in investigation of the dynamic behavior of cell aggregation in stem cell cultures in vitro. © 2015 International Society for Advancement of Cytometry
Postponement in Retail Supply Chain Management : A systematic data gathering survey

Postponement as a tool of creating flexibility is not a new concept. It traces back in literature to the 1950’s but was mainly argued as a method useful for manufacturing. However, postponement could potentially be used in all different parts of an organization to delay certain activities, and thereby create flexibility, which is crucial in today’s volatile marketplace. Customers are requiring customized products, yet they are not willing to pay premium for processes involved. Also, competition is increasing, as retailers around the globe compete with each other due to internet and improved information systems.This study focuses on a retailer’s perspective in the supply chain, as previous studies mainly discuss manufacturers, and their different abilities of achieving flexibility. Supply chain management as a concept are discussed, which is described as an integrative approach to dealing with the planning and control of the materials flow from suppliers to end users. This will further be “extended” to demand chain management, where focus lies at customers’ demand and puts emphasis on the needs of the marketplace and identifies the roles and tasks to be designed in the supply chain to satisfy these needs, instead of starting with the supplier/manufacturer and working forward. This is closely connected to flexibility, and postponement as a tool to achieve this. Flexibility as such, is described as the ability to change, or adapt to customer demand.This study aims to explore the Swedish retailing business, and their use of postponement strategies. A quantitative study has been made to be able to create a general picture of their use of this tool, as well as their prerequisite for adopting this tool. This study shows that retailing in general do have adopted strategies for customizations except non-specialized stores where answers to a wide extent differed regarding their use of flexibility. However, these strategies mainly regard packaging, and/or basic customizations. Depending on the market certain retailers are active within; postponement is used in various extents. Expensive products, or customers requiring big quantities of products, are able to get these customized. Money is almost always the main concern in these adaptations. Some factors that have been studied, that were enablers of flexibility and postponement strategies, were not able to be analyzed as very low results were calculated. However, the main-factors: flexibility and postponement were able to be analyzed in detail, as well as discussions regarding the inconclusive data gathered.
Comparison of a speech-based and a pie-menu-based interaction metaphor for application control

Choosing an adequate system control technique is crucial to support complex interaction scenarios in virtual reality applications. In this work, we compare an existing hierarchical pie-menu-based approach with a speech-recognition-based one in terms of task performance and user experience in a formal user study. As testbed, we use a factory planning application featuring a large set of system control options.
Visual end-user programming in smart homes: Complexity and performance

End-user programming in smart homes addresses tasks that range from very simple to very complex. In this study we investigate how task complexity impacts performance when using two different visual programing representations: form-filling and data-flow programming. We invited 16 participants to create rules to solve smart-home situations of varying complexity and analyzed their completion rates for the two visual programming representations. We identify the following areas of difficulty for programming novices in our smart home scenario: choosing and connecting triggers and their specifications, and using Boolean operators. Both visual representations enabled users to specify complex rules, with advantages in different areas. They indicate that overall task complexity might be less decisive for performance than complexity of triggers and Boolean operators.
Gemcitabine for Advanced Endometrial Cancer: A Retrospective Study of the Memorial Sloan-Kettering Cancer Center Experience

Background Gemcitabine is active in several gynecologic malignancies including ovarian cancer, cervical cancer, and uterine leiomyosarcoma. It has been used in an off-label setting for the treatment of advanced endometrial cancer, despite lack of published data showing efficacy. We performed a retrospective study to determine the progression-free survival and response rate of endometrial cancer patients treated with gemcitabine at Memorial Sloan-Kettering Cancer Center. Methods Eligible patients had histologically confirmed advanced (stage IV or recurrent) endometrial cancer that was treated with single-agent gemcitabine at Memorial Sloan-Kettering Cancer Center between 1999 and 2009. Response to therapy was determined by review of computed tomography imaging by Response Evaluation Criteria in Solid Tumors 1.1 criteria. Results Forty-six patients were included in the analysis. Median age was 66 years (range, 52–87 years). All patients were previously treated with chemotherapy. The median number of prior lines of chemotherapy was 2 (range, 1–8). Median dose of gemcitabine administered was 800 mg/m2 infused on days 1 and 8 of a 21-day cycle. Predominant histology was endometrioid (48%, n = 22) followed by serous (35%, n = 16), clear cell (15%, n = 7), and undifferentiated (2%, n = 1). Overall response rate was 10.9% (95% confidence interval, 1.9%–19.9%); 5 patients (11%) achieved a partial response. Thirteen patients (28%) displayed stable disease lasting at least 3 months. Of note, 5 (71%) of the 7 patients with clear cell histology displayed stable disease or partial response (n = 5). The median progression-free survival was 3.0 months (95% confidence interval, 2.1–3.3 months). Nonhematologic grades 3 and 4 toxicities were rare. Ten patients (22%) were treated with granulocyte colony-stimulating factor during treatment. Grade 3 thrombocytopenia was seen in 4 patients (9%). There were no cases of grade 4 thrombocytopenia. Conclusions In a mixed population of patients with previously treated advanced endometrial cancer, gemcitabine was well tolerated and showed modest activity. Patients with clear cell histology appeared to have greater likelihood of benefit.
Methodological and Practical Aspects of Rural Land Market Assessment - the Polish Example

The aim of paper is to present the methodological base for performing markets analysis. The observation area comprised local rural property markets in Poland, characterised by a mall number of transaction. The land market in Poland, especially concerning rural area, is still developing. This is caused by the fact that the economic condition and legal instrument necessary for its emergence have been created quite recently. It is followed by conditions in which the traditional models of market estimation, applied in Western World may not be always successfully used on the real estate markets in the Central and Eastern Europe. There are the cases in which it is impossible even to determine the state of the market of real estates in direct way. This results from the imperfection of land marked surrounding, which manifest itself, amongst others, in relatively low number of transaction. Therefore, especial and simplified market analyses approach is needed to describe and quantify the mechanism of price creation and to find an indirect methods of estimating the contemporary state, necessary correction and expected future time of normalisation the market situation.
Expression, Content, and Localization of Insulin-Like Growth Factor I in Human Achilles Tendon

In animals insulin-like growth factor I (IGF-I) stimulates collagen production by fibroblasts and is expressed in tendons together with its binding protein 4 (IGFBP-4). However, the presence of IGF-I and IGFBP-4 in human tendon tissue is not described. Tissue IGF-I content was examined by immunoflourometric assay, real-time PCR, and immunohistochemistry used to localize and determine expression of IGF-I and IGFBP-4 in 6 postmortem human Achilles tendons. Tendon tissue concentrations of IGF-I were found to be 0.53 ± 0.10 ng/g. Furthermore, we demonstrated that IGF-I and IGFBP-4 are localized around the tendon fibroblasts and that mRNA for IGF-I and IGFBP-4 can be determined in human tendon tissue. The present study adds support for the roles of IGF-I and IGFBP-4 in the regulation of tendon adaptive responses to mechanical loading.
Weighted Algebraic Connectivity Maximization for Optical Satellite Networks

In this paper, the topology configuration methods for heterogeneous optical satellite networks are investigated. Our objectives are to maximize weighted algebraic connectivity with respect to both network initialization and reconfiguration scenarios subject to onboard hardware constraints. The problems are not strictly convex and have been proven as NP-hard. In order to solve the problems in polynomial time, the original problems are relaxed to a convex optimization problem. Specifically, the relaxed problem is transformed to a positive semidefinite programming form, which can be solved exactly and more efficiently. Furthermore, based on the perturbation theory of matrices, we propose two greedy heuristic methods to deal with the initialization and reconfiguration case from the relaxed solutions, respectively. Simulation results show that the proposed algorithms are able to accomplish network initialization and reconfiguration correctly in the overwhelming majority of situations. The final sub-optimal solutions can also be obtained under low computational complexity.
Evaluation of the performance of using mean absolute amplitude analysis of thoracic and abdominal signals for immediate indication of sleep apnoea events.

AIM To evaluate the sensitivity of mean absolute amplitudes of the thoracic and the abdominal signals as a prompt indicator of the occurrence of sleep apnoea events. BACKGROUND To provide symptomatic management of sleep apnoea, a reliable method of detecting sleep apnoea is essential to ensure that the intervention can be applied only when needed. It is also crucial to identify the threshold for the trigger of an intervention using a deployed sensor. DESIGN Twenty-six subjects aged between 18-65 years who were diagnosed with obstructive or central sleep apnoea underwent an overnight sleep study. METHOD Signals of nasal and oral airflow, thoracic and abdominal efforts and pulse oximetry level were recorded using a polysomnography device. RESULTS With a 95% CI, the overall area under the receiver operating characteristic of the thoracic signal, the abdominal signal and the combination of the thoracic and the abdominal signals were 84.56, 87.48 and 90.91%, respectively. Using -20, -25 and -30% as a cut-off point, the sensitivity values of thoracic signal, abdominal signal and combination of the thoracic and the abdominal signals ranged from 70.29-86.25% and the specificity values ranged from 74.82 to 90.09%. CONCLUSIONS Using mean absolute amplitude analysis, the results of this study showed that combination of the thoracic and the abdominal signals achieved the best overall and individual performances compared with thoracic signal and abdominal signal. Overall, thoracic signal, abdominal signal and combination of the thoracic and the abdominal signals have a good performance with an receiver operating characteristic value higher than 80%. The thoracic and the abdominal signals were good parameters for the identification of the occurrence of sleep apnoea, being as quick as the nasal airflow signal. RELEVANCE TO CLINICAL PRACTICE These results suggested that sleep apnoea events could be identified through constant monitoring of the patient's thoracic and abdominal signals. Knowledge of these signals could help nurses to manage sleep apnoea in patients.
Free energy levels and entropy production associated with biochemical kinetic diagrams.

"Basic" and "gross" free energy levels are defined for the discrete states of a macromolecular biochemical kinetic system such as a free energy transducing enzyme (e.g., myosin or Na,K-ATPase). Basic free energy level differences are related to the first-order rate constants for transitions between states while gross free energy differences, along with the corresponding fluxes, determine the rate of entropy production in the system. In muscle contraction the analysis is complicated by the possibility of the system doing external mechanical work. The question of the sign of the flux or of the gross free energy level change in a given transition is examined for both single-cycle and multi-cycle models. More definite statements can be made in single-cycle cases. Some numerical examples are included. The more complicated cases are reserved for a subsequent paper.
Effectiveness of knowledge-based multinational management on global supply chain excellence

In current business management, knowledge is considered to be a strategic resource that can strengthen an organization’s competitiveness. Today, under the process of continuous globalization, almost all companies are rapidly exposed to global competition regardless of their scale or type of business. However, multinational management is very complicated and uncertain and it is hard for multinationals to effectively coordinate and manage their global value chains. In light of this, the utility of multinational management based on knowledge is increased. The present study examines multinational firms’ knowledge management systems, knowledge creation processes and global supply chain performance and attempts to reveal any significant linkages between these latent variables. For this research interest, we proposed 18 items to measure four types of knowledge creation processes (SECI) designed by Nonaka (1994) and revised by authors considering the global business environment, in particular involving the global supply chain management concept. Utilizing the confirmed SECI model, 128 sample companies were classified into four groups according to the levels of their knowledge creation processes. The empirical results of this study reveal important linkages between a multinational firm’s knowledge management system and knowledge creation process, as well as between its knowledge creation process and global supply chain management performance. In particular, the current work suggests that the creation and conversion of tacit knowledge as well as explicit knowledge can be effectively supported by information and communication technology.
THE EFFECT OF THE METHANOL EXTRACT OF GALIUM MITE ON THE CELLULAR IMMUNITY AND ANTIBODY SYNTHESIS

In the present study, the immunomodulatory effects of Galium mite, a native herb used for the treatment of inflammation in Iranian traditional medicine, was investigated. The methanolic extract of the plant was prepared and examined for in vivo cell-mediated and humoral immunity against antigen in mice. Galium mite stimulated delayed type hypersensitivity at lower concentrations and inhibited the reaction at higher ones (p < 0.05). A dose-related decrease in primary and secondary antibody titer was observed in mice treated with the extract (p < 0.006). The extract at higher concentrations significantly reduced the proliferation of human-activated lymphocytes (p < 0.001). Cell cycle analysis on human lymphocytes treated with the extract showed an increase in the number of cells in sub-G1 region, indicating the ability of the extract to induce apoptosis in these cells. Induction of apoptosis was confirmed by DNA laddering on gel electrophoresis. In conclusion, G. mite has the ability to modulate cellular and humoral immune responses to the antigenic challenge and affect the rate of cell proliferation due to induction of apoptosis in the lymphocytes.
Comparison of the clinical informativeness of photographs and digital imaging media with multiple-choice receiver operating characteristic analysis.

BACKGROUND AND DESIGN Electronic medical imaging is important for medical informatics, computerized learning, and especially for the growing field of telemedicine. The image resolution necessary for a clinical application can be determined by use of receiver operating characteristic (ROC) experiments. Completely profiling display systems is a tedious process, requiring multiple ROC experiments. We have developed a multiple-choice ROC analysis technique to compare the relative informativeness of digital image formats for a spectrum of cutaneous lesions simultaneously. The technique makes use of logical competitor sets (LCSs) of clinical conditions to redefine multiple-choice responses into the present/absent framework required for conventional ROC curve construction. The study divided 180 slides and digital images into three LCSs: pigmented lesions, flesh-colored papules, and papulosquamous conditions. Eight dermatologists diagnosed the lesions presented in two randomized viewing sessions. Accuracy profiles, independent of individual observer sensitivities, were derived from the responses. RESULTS The informativeness of color slides and digital images was statistically similar, even when the conditions were stratified by difficulty of diagnosis. Results for nine specific skin conditions represented in the three LCSs were obtained simultaneously. CONCLUSIONS Digital images appear to be as informative as slides for specific dermatologic diagnoses in the three LCSs tested. The use of LCSs allows stratification of results by diagnosis with greater efficiency than multiple repeated ROC experiments. Multiple-choice ROC analysis used in conjunction with logical competitor sets is the best currently available method for comparing imaging media for use in visual disciplines such as dermatology, radiology, pathology, and others.