Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo

We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 µmol/L) of resveratrol. For experimental metastasis, BALB/c mice were injected intravenously with 4T1 cells in the tail vein, and were orally administered various concentrations (0, 100, or 200 mg/kg Body weight) of resveratrol for 21 days. After resveratrol treatment, cell adhesion, wound migration, invasion, and MMP-9 activity were significantly decreased in a dose-dependent manner in 4T1 cells (P < 0.05). The numbers of pulmonary nodules were significantly decreased in mice fed the resveratrol (P < 0.05). The plasma MMP-9 activity was decreased in response to treatment with resveratrol in mice (P < 0.05). We conclude that resveratrol inhibits cancer metastasis both in vitro and in vivo, and this inhibition is likely due to the decrease in MMP-9 activity caused by resveratrol.
Optimal Design for Rectifier Transformer Using Improved PSO Algorithm

An improved partial swarm optimization algorithm (IPSO) that can overcome the disadvantages of trapping in local optimum in the standard PSO algorithm is proposed for rectifier transformer optimal design. In the calculation process of IPSO, the max iteration is divided into a number of sections by control factor. At the beginning of each section, the single particle inertia weight is determined by the comparing result between its own fitness function value and the average fitness function value of the particle swarm. Therefore, the particles with good fitness function value will trend to make local search, and the ones with poor fitness function value will do rough detection in the completely feasible region to discover new better solution. Therefore, the IPSO has a good effort to adjust the dynamic balance between swarm’s convergence and individual’s diversity. A systematic optimal design method of rectifier transformer was proposed based on the IPSO. The feasibility and validity of the proposed method are proved by the contrast between handwork results and IPSO results.
The Value of Admission Clinical Data for Diagnosing Heart Failure in Long-term Care

Background Heart failure (HF) is common in long-term care (LTC). Diagnostic uncertainty is important barrier to optimal HF management, stemming from inadequate health information transfer upon LTC admission. We determine the utility of admission clinical information to confirm a HF diagnosis in new LTC residents. Methods This was a prospective cohort study. From February 2004 to November 2006, information about new residents from 41 LTC homes in Ontario, Canada, was collected from residents and caregivers, and all available health records. A prior HF diagnosis was confirmed by consensus review of available data by two independent experts. Multivariate modelling was utilized to determine the utility of the admission clinical assessment in confirming a prior HF diagnosis. Results A total of 449 residents were included for analysis, aged 84.3±6.5 years, and 21.6% had a prior HF diagnosis. The most useful clinical item for diagnosing HF was a “history of HF”. The final model included “history of HF’ (OR [odds ratio] 13.66, 95% CI 6.61–28.24), “fluid on the lungs” (OR 2.01, 95% CI 1.04–3.89), “orthopnea” (OR 1.76, 95% CI 0.93–3.33), “taking β-blocker” (OR 2.09, 95% CI 1.10–3.94), “taking loop diuretics” (OR 2.11, 95% CI 1.12–3.98), and “history of coronary artery disease” (OR 2.83, 95% CI 1.42–5.64). Conclusion Elements of the clinical assessment for new LTC residents can help confirm a prior HF diagnosis. An admission history of HF is highly predictive.
MOBYSIM: An integrated traffic simulation platform

Research and societal questions in the area of mobility are becoming more and more complex, covering many different aspects of the traffic system. Simulation tools are an important aid in the study of such questions. Their complexity requires an integrated mixed reality environment, in which the tools are connected to each other and to external data sources. This paper presents the methodology and considerations for designing such a platform and one of its key constituent tools, a microscopic traffic simulation tool. This is applied to design the platform MOBYSIM, with the traffic simulator ITS Modeller.
A space/time tradeoff methodology using higher-order functions

Large digital signal processing applications like particle filtering require a tradeoff between execution time and area in order to scale on FPGAs. This research focuses on developing a methodology to make this tradeoff based on structure in the mathematical description of the application. Structure is expressed using higher-order functions which are transformed using tradeoff rules to reduce area usage on FPGA.
Can God & Caesar coexist? : balancing religious freedom and international law

Father Robert F. Drinan--priest, scholar, lawyer, politician, activist, and ethicist--has spent his life working to strengthen human rights. In this important book, Father Drinan explores the state of religious freedom worldwide, arguing that international law and legal institutions have not gone far enough to protect religious freedom. The international community, says Father Drinan, has been slow to recognize the urgent need of balancing the requirements of a pluralistic society with the demands of religious freedom. Despite numerous proclamations from the United Nations and from individual nations about the importance of religious freedom, says Father Drinan, there is still no covenant, legally binding instrument, or world tribunal to monitor freedom of religion. Drinan explores the status of religious freedom in certain Christian, Muslim, Jewish, and Communist societies whose doctrines may promote intolerance. And he asserts that the silence of international law allows nations to continue to punish persons who practice a faith viewed unfavorably by the government.
Fusion of structures of finite Morleyrank ∗

Let T1 and T2 be two countable complete theories in disjoint languages, of finite Morley rank, the same Morley degree, with definable Morley rank and degree. Let N be a common multiple of the ranks of T1 and T2. We show that T1 ∪ T2 has a nice complete expansion of Morley rank N .
Evaluating Brazilian mutual funds with stochastic frontiers

We evaluate the performance of 307 Brazilian stock mutual funds employing stochastic frontiers. We list the top ten actively managed funds and the bottom ten for the period April 2001-July 2003, and show that a fund's efficiency increases with management skill to beat the market. We also find that portfolios with low volatility tend to be more efficient. Yet we find no relationship between fund size and performance, though this might be blurred by a survivorship bias.
Pipelining Argumentation Technologies

Software tools for working with argument generally exist as large systems that wrap their entire feature set in the application as a whole. This approach, while perfectly valid, can result in users having to use small parts of multiple systems to carry out a specific task. In this paper, we present a series of web services, that each encapsulate small pieces of functionality for working with argument. We then demonstrate two example systems built by connecting these services in the form of a UNIX-style pipeline.
Estimating the Global Prevalence of Zinc Deficiency: Results Based on Zinc Availability in National Food Supplies and the Prevalence of Stunting

Background Adequate zinc nutrition is essential for adequate growth, immunocompetence and neurobehavioral development, but limited information on population zinc status hinders the expansion of interventions to control zinc deficiency. The present analyses were conducted to: (1) estimate the country-specific prevalence of inadequate zinc intake; and (2) investigate relationships between country-specific estimated prevalence of dietary zinc inadequacy and dietary patterns and stunting prevalence. Methodology and Principal Findings National food balance sheet data were obtained from the Food and Agriculture Organization of the United Nations. Country-specific estimated prevalence of inadequate zinc intake were calculated based on the estimated absorbable zinc content of the national food supply, International Zinc Nutrition Consultative Group estimated physiological requirements for absorbed zinc, and demographic data obtained from United Nations estimates. Stunting data were obtained from a recent systematic analysis based on World Health Organization growth standards. An estimated 17.3% of the world’s population is at risk of inadequate zinc intake. Country-specific estimated prevalence of inadequate zinc intake was negatively correlated with the total energy and zinc contents of the national food supply and the percent of zinc obtained from animal source foods, and positively correlated with the phytate: zinc molar ratio of the food supply. The estimated prevalence of inadequate zinc intake was correlated with the prevalence of stunting (low height-for-age) in children under five years of age (r = 0.48, P<0.001). Conclusions and Significance These results, which indicate that inadequate dietary zinc intake may be fairly common, particularly in Sub-Saharan Africa and South Asia, allow inter-country comparisons regarding the relative likelihood of zinc deficiency as a public health problem. Data from these analyses should be used to determine the need for direct biochemical and dietary assessments of population zinc status, as part of nationally representative nutritional surveys targeting countries estimated to be at high risk.
Designing feedback algorithms for controlling the periodic motions of legged robots

A nonlinear feedback control algorithm is developed for repetitive legged robotic locomotion whose global dynamic behavior can be encoded in a Poincare return map. Control synthesis is equivalent to the selection of a nonlinear feedback control law which properly shapes the return map. A method is presented for return map shaping in a neighborhood of a fixed point. In practice, this neighborhood can be quite large. The theory is illustrated with applications to a simplified model of Raibert's hopping machines. An added benefit is accurate control of hopping height above undulating terrain. <<ETX>>
Joins on Encoded and Partitioned Data

Compression has historically been used to reduce the cost of storage, I/Os from that storage, and buffer pool utilization, at the expense of the CPU required to decompress data every time it is queried. However, significant additional CPU efficiencies can be achieved by deferring decompression as late in query processing as possible and performing query processing operations directly on the still-compressed data. In this paper, we investigate the benefits and challenges of performing joins on compressed (or encoded) data. We demonstrate the benefit of independently optimizing the compression scheme of each join column, even though join predicates relating values from multiple columns may require translation of the encoding of one join column into the encoding of the other. We also show the benefit of compressing "payload" data other than the join columns "on the fly," to minimize the size of hash tables used in the join. By partitioning the domain of each column and defining separate dictionaries for each partition, we can achieve even better overall compression as well as increased flexibility in dealing with new values introduced by updates. Instead of decompressing both join columns participating in a join to resolve their different compression schemes, our system performs a light-weight mapping of only qualifying rows from one of the join columns to the encoding space of the other at run time. Consequently, join predicates can be applied directly on the compressed data. We call this procedure encoding translation. Two alternatives of encoding translation are developed and compared in the paper. We provide a comprehensive evaluation of these alternatives using product implementations of each on the TPC-H data set, and demonstrate that performing joins on encoded and partitioned data achieves both superior performance and excellent compression.
ON KERNEL DENSITY ESTIMATION WITHOUT BUMPS IN THE TAILS

An empirical approach to bandwidth choice is proposed for nonpara-metric estimation of the tails of a probability density. It is an \equal-information" method, in that it uses approximately equal amounts of sample information to estimate the density at all points. In one respect it is related to nearest neighbour methods, although it produces substantially smoother estimates, without the spikes associated with nearest neighbour analysis. In the tails it enjoys low relative error, as well as low absolute error, and as a result the tail estimates do not exhibit the familiar \bumpy" appearance which impedes both modal analysis and qualitative interpretation of curve estimates. Indeed, one of the applications of our technique is to bump-hunting methods, where it allows standard approaches to be improved.
Phonons and related crystal properties from density-functional perturbation theory

This article reviews the current status of lattice-dynamical calculations in crystals, using density-functional perturbation theory, with emphasis on the plane-wave pseudopotential method. Several specialized topics are treated, including the implementation for metals, the calculation of the response to macroscopic electric fields and their relevance to long-wavelength vibrations in polar materials, the response to strain deformations, and higher-order responses. The success of this methodology is demonstrated with a number of applications existing in the literature.
Chinese Whispers: Cooperative Paraphrase Acquisition

We present a framework for the acquisition of sentential paraphrases based on crowdsourcing. The proposed method maximizes the lexical divergence between an original sentence s and its valid paraphrases by running a sequence of paraphrasing jobs carried out by a crowd of non-expert workers. Instead of collecting direct paraphrases of s, at each step of the sequence workers manipulate semantically equivalent reformulations produced in the previous round. We applied this method to paraphrase English sentences extracted from Wikipedia. Our results show that, keeping at each round n the most promising paraphrases (i.e. the more lexically dissimilar from those acquired at round n-1), the monotonic increase of divergence allows to collect good-quality paraphrases in a cost-effective manner.
Singing Voice Separation Using Spectro-Temporal Modulation Features

A n auditory-perception inspired singing voice separation algorithm for monaural music recordings is proposed in this paper. Under the framework of computational auditory scene analysis (CASA), the music recordings are first transformed into auditory spectrograms. After extracting the spectral-temporal modulation contents of the timefrequency (T-F) units through a two-stage auditory model, we define modulation features pertaining to three categories in music audio signals: vocal, harmonic, and percussive. The T-F units are then clustered into three categories and the singing voice is synthesized from T-F units in the vocal category via time-frequency masking. The algorithm was tested using the MIR-1K dataset and demonstrated comparable results to other unsupervised masking approaches. Meanwhile, the set of novel features gives a possible explanation on how the auditory cortex analyzes and identifies singing voice in music audio mixtures.
Are SNP-Smoking Association Studies Needed in Controls? DNA Repair Gene Polymorphisms and Smoking Intensity

Variations in tobacco-related cancers, incidence and prevalence reflect differences in tobacco consumption in addition to genetic factors. Besides, genes related to lung cancer risk could be related to smoking behavior. Polymorphisms altering DNA repair capacity may lead to synergistic effects with tobacco carcinogen-induced lung cancer risk. Common problems in genetic association studies, such as presence of gene-by-environment (G x E) correlation in the population, may reduce the validity of these designs. The main purpose of this study was to evaluate the independence assumption for selected SNPs and smoking behaviour in a cohort of 320 healthy Spanish smokers. We found an association between the wild type alleles of XRCC3 Thr241Met or KLC3 Lys751Gln and greater smoking intensity (OR = 12.98, 95% CI = 2.86–58.82 and OR=16.90, 95% CI=2.09-142.8; respectively). Although preliminary, the results of our study provide evidence that genetic variations in DNA-repair genes may influence both smoking habits and the development of lung cancer. Population-specific G x E studies should be carried out when genetic and environmental factors interact to cause the disease.
Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis

Objective Although physical therapy can help preserve mobility in patients with systemic sclerosis (SSc), stretching has not been used systematically as a treatment to prevent or reverse the disease process. We previously showed in rodent models that stretching promotes the resolution of connective tissue inflammation and reduces new collagen formation after injury. Here, we tested the hypothesis that stretching would impact scleroderma development using a mouse sclerodermatous graft-versus-host disease (sclGvHD) model. Methods The model consists in the adoptive transfer (allogeneic) of splenocytes from B10.D2 mice (graft) into Rag2−/− BALB/c hosts (sclGvHD), resulting in skin inflammation followed by fibrosis over 4 weeks. SclGvHD mice and controls were randomized to stretching in vivo for 10 min daily versus no stretching. Results Weekly ultrasound measurements of skin thickness and subcutaneous tissue mobility in the back (relative tissue displacement during passive trunk motion) successfully captured the different phases of the sclGvHD model. Stretching reduced skin thickness and increased subcutaneous tissue mobility compared to no stretching at week 3. Stretching also reduced the expression of CCL2 and ADAM8 in the skin at week 4, which are two genes known to be upregulated in both murine sclGvHD and the inflammatory subset of human SSc. However, there was no evidence that stretching attenuated inflammation at week 2. Conclusion Daily stretching for 10 min can improve skin thickness and mobility in the absence of any other treatment in the sclGvHD murine model. These pre-clinical results suggest that a systematic investigation of stretching as a therapeutic modality is warranted in patients with SSc.
A Running Example : Animals

This paper presents an OO style without classes, which we call interface-based object-oriented programming (IB). This style is a natural extension of closely related ideas such as traits. To support state, IB uses abstract state operations. This new way to deal with state allows flexibility not available in class-based languages. In IB state can be type-refined in subtypes. The combination of a purely IB style and type-refinement enables powerful idioms using multiple inheritance and state. To introduce IB to programmers we created Classless Java: an embedding of IB directly into Java. Classless Java uses annotation processing for code generation and relies on new features of Java 8 for interfaces. The code generation techniques used in Classless Java have interesting properties, including guarantees that the generated code is type-safe and good integration with IDEs. Usefulness of IB and Classless Java is shown with examples and case studies.
Flow Oriented Channel Assignment for Multi-radio Wireless Mesh Networks

We investigate channel assignment for a multichannel wireless mesh network backbone, where each router is equipped with multiple interfaces. Of particular interest is the development of channel assignment heuristics for multiple flows. We present an optimization formulation and then propose two iterative flow oriented heuristics for the conflict-free and interference-aware cases, respectively. To maximize the aggregate useful end-to-end flow rates, both algorithms identify and resolve congestion at instantaneous bottleneck link in each iteration. Then the link rate is optimally allocated among contending flows that share this link by solving a linear programming (LP) problem. A thorough performance evaluation is undertaken as a function of the number of channels and interfaces/node and the number of contending flows. The performance of our algorithm is shown to be significantly superior to best known algorithm in its class in multichannel limited radio scenarios.
normal breast : Association with tumor response in breast cancer patients receiving neoadjuvant chemotherapy

PURPOSE: This study investigated the association between background parenchymal enhancement (BPE) and pathologic response to neoadjuvant chemotherapy (NAC). METHODS: A total of 46 patients diagnosed with invasive breast cancerwere analyzed. Each patient had threemagnetic resonance imaging (MRI) studies, one pre-treatment and two follow-up (F/U)MRI studies. BPEwasmeasured as the averaged enhancement of thewhole fibroglandular tissues. The pre-treatment BPE and the changes in the F/U MRI were compared between patients achieving pathologic complete response (pCR) versus those not. Subgroup analyses based on age, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) status of their cancers were also performed. RESULTS: The pre-treatment BPEwas higher in the pCR group than that in the non-pCR group. Compared to baseline, BPE at F/U-1 was significantly decreased in the pCR group but not in the non-pCR group. In subgroup analysis based on age, these results were seen only in the younger group (b55 years old), not in the older group (≥55 years old). Older patients had a significantly lower pre-treatment BPE than younger patients. In analysis based onmolecular biomarkers, a significantly decreased BPE at F/U-1 was only found in the ER-negative pCR group but not in the non-pCR, nor in the ER-positive groups. CONCLUSIONS: A higher pre-treatment BPE showing a significant decrease early after starting NAC was related to pCR in pre/peri-menopausal patients. Translational Oncology (2015) 8, 204–209 Address all correspondence to: Jeon-Hor Chen, MD, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California Irvine, No. 164, Irvine Hall, Irvine, CA, 92697-5020, USA. E-mail: jeonhc@uci.edu This work was supported in part by National Health Institute/National Cancer Institute grants R01 CA127927, R21 CA170955, and R03 CA136071. Competing interests: The authors declare that they have no competing interests. Authors' contributions: J.H. C. designed the case-control study used for this analysis, did the literature review, interpreted the results, and drafted the manuscript. H.J.Y. did the measurement and analysis of the background parenchymal enhancement data. C.H. ran the computer algorithm and did the breast and fibroglandular tissue segmentations. R.S. M. recruited subjects and performed breast magnetic resonance imaging (MRI) studies. P.M. C. performed pathologic examination of the breast specimen. M.Y. S. designed the case-control study and interpreted the results. All authors edited the manuscript and approved the final manuscript submitted for publication. Received 23 January 2015; Revised 8 April 2015; Accepted 9 April 2015 © 2015 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/). 1936-5233/15 http://dx.doi. org/10.1016/j.tranon. 2015.04.00