Miracle-dz/UniFAR-FTUs huggingface dataset:
Reference values for arterial blood gases in the elderly.

OBJECTIVES We present reference values for arterial blood gas measurements for persons > 70 years old. At the same time, we wish to examine how different criteria for exclusion from the reference sample with regard to previous smoking and various comorbidities might influence reference values. METHODS After first screening a random sample of the general elderly population by postal questionnaire, we selected 146 men and women without respiratory disease, significant dyspnea, symptomatic heart disease or hypertension, or current smoker status. Arterial blood samples were drawn from subjects while in the supine position. RESULTS The mean (SD; lower limit of normal) PaO(2) and arterial oxygen saturation (SaO(2)) for men was 77.0 mm Hg (9.1; 62.0) and 95.3% (1.4; 93.0), respectively, and for women was 73.5 mm Hg (8.4; 59.6) and 94.8% (1.7; 92.0). Mean (SD; upper limit of normal) PaCO(2) was 39.4 mm Hg (3.3; 44.8) for both sexes. None of the blood gas variables were associated with age, smoking history, or presence of various comorbidities. CONCLUSIONS The reference values for PaO(2) and SaO(2) in elderly persons are sex specific but age independent. Ex-smokers and persons with nonpulmonary comorbidities who do not have significant respiratory symptoms need not be excluded from the reference sample for arterial blood gases.
Processes of Political Socialization

By analyzing data from a national panel survey of adolescents (ages 12-17) and their parents conducted around the 2008 general election, this study explores the varied roles communication plays in socializing youth into democratic citizenship. In particular, we propose and test a communication mediation model of youth socialization, in which interdependent communication processes located in the family, schools, media, and peer networks combine to cultivate communication competence, a set of basic communication skills and motives needed for active and informed participation in public life. Analysis of our panel data indicates that participation in deliberative classroom activities and democratic peer norms contribute to civic activism among youth. These peer and school influences, however, are found to be largely indirect, working through informational use of conventional and online news media, and expression and discussion of political ideas outside of classroom and family boundaries. In particular, our findings highlight strong online pathways to participation, centering on news consumption and political expression via digital media technologies, suggesting the key role of the Internet in this dynamic.
High‐resolution density gradient electrophoresis of proteins and subcellular organelles

Following a concept developed by Bier et al. (Electrophoresis 1993, 14, 1011–1018), binary mixtures of amphoteric buffers with low conductivity and a good buffering capacity permit rapid rate zonal separation of proteins on a density gradient electrophoresis apparatus (7 cm, Ø 2.2 cm). At pH 8.66 and 250 V, β‐lactoglobulin (Mr 36 600) was separated into the A and B isoforms within 44 min; human transferrin (Mr 76 000–81 000) was separated into its sialylated glycoforms and carbonic anhydrase (Mr 30 000) separated into its isoenzymes. From these results we arrive at the term high‐performance density gradient electrophoresis. Compartments belonging to the endosomal system were separated by density gradient electrophoresis. Early endosomes, recycling vesicles, intermediate endosomes, late endosomes and lysomes became well‐separated after 80 min at 10 mA using [125I]transferrin and horseradish peroxidase as reporter molecules in pulse‐chase regimes. Mixtures of Bier buffers and standard electrophoresis media permitted very short separation times (19 min at 10 mA) for the endosomal compartments. Concommittantly, endoplasmic reticulum and proteasomes were well resolved.
Análise comparativa de algoritmos de mineração de texto aplicados a históricos de contas públicas

O uso de Mineracao de Texto (MT) e importante para o processo de extracao de conhecimento em bases textuais. Contudo, e importante avaliar se o conhecimento extraido ou gerado e relevante ou nao para o usuario. Diante destas constatacoes, objetivou-se, com este trabalho, no âmbito das atividades de auditoria realizadas no Tribunal de Contas do Estado de Sergipe (TCE-SE), o desenvolvimento de um algoritmo de mineracao de texto para a ferramenta TextMining (solucao de MT do TCE-SE), bem como a avaliacao de performance dos algoritmos de mineracao de texto da ferramenta. Tal avaliacao foi realizada mediante um estudo de caso nos historicos de contas publicas para detectar irregularidades no pagamento de diarias.
Relationships between Graph Edit Distance and Maximal Common Structural Subgraph

Graph edit distance measures the distance between two graphs as the number of elementary operations (vertex/edge insertion, deletion, substitution) required to transform the first graph into the second one. Such a distance allows to define a metric between graphs and has many applications in the structural pattern recognition framework. However, the complexity of the computation of this distance is exponential in the size of both graphs to be compared. In this technical report, we focus our attention on applications where families of graphs to be considered have a finite set of structures. We then investigate under which relationships between the costs of the different elementary operations, such a priori knowledge may be used to pre compute most of the optimal edit path between any two graphs.
Phylogeny of Deltocephalinae(Hemiptera:Cicadellidae) from China based on partial 16S rDNA and 28S rDNA D2 sequences combined with morphological characters

The phylogeny of 19 genera of Deltocephalinae leafhoppers was analyzed based on 50 adult morphological characters combined with nucleotide sequences of the mitochondrial 16S rDNA and nuclear 28S D2 rDNA genes. One species of Typhlocybinae was included as outgroup. Parsimonian, distance and Bayesian methods were used to estimate the phylogenetic relationships. The topology of the phylogenetic trees generated with different methods was quite similar. We partially resolved the morphologically-defined tribes and the relationships among 19 genera of Deltocephalinae. The genus Macrosteles was well supported to occupy a basal position in the study, so the most primary tribe in Deltocephalinae might be Macrostelini. The phylogenetic analysis trees put all genera of Deltocephalini but Nakaharanus onto a single lineage. The genus Balclutha, corresponding to the tribe Balcluthini, remains unsolved in our analyses. The Euscelini might be a polyphyletic group in the analysis. Analytical result recovered Athysanini and Paralimnini as monophyletic clades. The clade Phlogotettix and Scaphoideus-Nakaharanus was constantly resolved using different methods. We suggested that Scaphoideus, Nakaharanus and Phlogotettix should be included in or into Scaphoideini. But the results resolved poorly the taxonomic status of Xestocephalini overall.
A meta‐analytic approach to examining the correlation between religion/spirituality and mental health in cancer

Religion and spirituality (R/S) are patient‐centered factors and often are resources for managing the emotional sequelae of the cancer experience. Studies investigating the correlation between R/S (eg, beliefs, experiences, coping) and mental health (eg, depression, anxiety, well being) in cancer have used very heterogeneous measures and have produced correspondingly inconsistent results. A meaningful synthesis of these findings has been lacking; thus, the objective of this review was to conduct a meta‐analysis of the research on R/S and mental health. Four electronic databases were systematically reviewed, and 2073 abstracts met initial selection criteria. Reviewer pairs applied standardized coding schemes to extract indices of the correlation between R/S and mental health. In total, 617 effect sizes from 148 eligible studies were synthesized using meta‐analytic generalized estimating equations, and subgroup analyses were performed to examine moderators of effects. The estimated mean correlation (Fisher z) was 0.19 (95% confidence interval [CI], 0.16‐0.23), which varied as a function of R/S dimensions: affective R/S (z = 0.38; 95% CI, 0.33‐0.43), behavioral R/S (z = 0.03; 95% CI, −0.02‐0.08), cognitive R/S (z = 0.10; 95% CI, 0.06‐0.14), and ‘other’ R/S (z = 0.08; 95% CI, 0.03‐0.13). Aggregate, study‐level demographic and clinical factors were not predictive of the relation between R/S and mental health. There was little indication of publication or reporting biases. The correlation between R/S and mental health generally was positive. The strength of that correlation was modest and varied as a function of the R/S dimensions and mental health domains assessed. The identification of optimal R/S measures and more sophisticated methodological approaches are needed to advance research. Cancer 2015;121:3769–3778. © 2015 American Cancer Society.
Power Supply Module for System on Chip with Wide Input Range

This paper presents a power supply module (PSM) for SoCs (system on chip). This module, which is based on an improved LDO, has a wide input range and switchable power path. The proposed PSM can output a steady voltage of 6v as input voltage varies between 5.7 V-30 V, with a max error of 4.3%. It also provides a flexible power path. The SoCs will be supplied by either internal LDO or external power supply directly in corresponding applications. Further more, because of fast step of load condition in SoCs, a speedup loop was introduced to increase the stabilizing speed of output voltage, and up to 26.9% boost can be achieved according to simulation. The design accomplished under the 1.5 um BCD (Bipolar-CMOS-DMOS) technology.
CIRCULATORY REFLEXES IN PATIENTS WITH CEREBROVASCULAR DISEASE.

THE role of systemic hypotension in the genesis of local cerebral ischemia is not clear. Denny-Brown and Meyer1 and Denny-Brown2 have shown that a temporary fall in systemic blood pressure can produce a significant reduction in blood flow in a diseased part of the vascular tree supplying the brain, leading to the so-called hemodynamic crisis, and suggested this to be a cause of transient ischemic attacks. However, hypotension induced by tilting to the vertical plane2 3 4 or by the use of ganglion-blocking drugs5 was not associated with transient symptoms due to local ischemia in patients with cerebrovascular disease. Smirk and Hodge .
On the Multiwire Drift Chambers alignment of the HADES dilepton spectrometer

El experimento HADES, en el acelerador de iones pesados SIS en el laboratorio GSI (Darmstadt, Alemania) es una colaboracion internacional, principalmente para estudiar las propiedades de los mesones vectoriales con canal dileptonico de desintegracion de corta vida media (p, omega, *), en un medio de alta desnidad nuclear, analizando los pares de leptones producidos en colisiones nucleo-nucleo, con una energia de haz de entre 1 y 2 AGeV. El espectrometro consta de camara de deriva multihilo delante y detras de un campo magnetico toroidal inhomogeneo, para determinar el momento de las particulas. El alineamiento de estos detectores es fundamental para la determinacion precisa del momento. Despues de simular la influencia que una falta de alineamiento produce en el momento y en la masa invariante de los leptones, se define un metodo de alineamiento basado en la determinacion de las posiciones relativas de las camaras mediante algoritmos computacionales, analizando trazas rectilineas con el campo magnetico apagado, y la monitorizacion de los desplazamientos de las camaras durante las tomas de datos con campo magnetico, mediante un sistema optico de alineamiento. El sistema optico de alineamiento (RASNIK) se describe y comprueba, sobre todo en aquellas caracteristicas que influiran en la resolucion en la determinacion de la posicion. Se disena y construye un conjunto de soportes mecanicos que garanticen las posiciones relativas de los elementos de alineamiento. Despues de la calibracion del sistema experimental, se instala en el espectrometro y se analizan los resultados, demostrando una alta resolucion, mejor que la exigida a partir de los requisitos fisicos, correlacionando los desplazamientos con cambios en la temperatura y con el campo magnetico. Se describen a continuacion varios algoritmos para determinar la posicion relativa de dos o tres camaras, utilizando la informacion de los detecto
Reimagining digital publishing for technical documents

This workshop asks how we might reimagine digital publishing for technical documents and proposes to investigate new adaptive approaches to document reading with flexible navigation and where contextual information---figures, references, definitions, etc---might be displayed dynamically at the point they are referred to. The workshop ultimately seeks to answer the question of what needs to happen for reading and annotation of technical documents on digital devices to become more comfortable and productive than on paper?
Crystal structure of 5-fluoro-2-(3-fluorophenyl)-3-methylsulfinyl-1-benzofuran

In the title compound, C15H10F2O2S, the dihedral angle between the planes of the benzofuran ring system [r.m.s. deviation = 0.015 (1) Å] and the 3-fluorophenyl ring is 26.60 (5)°. In the crystal, molecules are linked by C—H⋯O and C—H⋯F hydrogen bonds, and by π–π interactions between the benzofuran rings of inversion-related molecules [centroid(benzene)–centroid(furan) distance = 3.819 (2) Å], forming a three-dimensional network.
A Quantitative Investigation of Chemorepulsion in Eukaryotic Systems

Chemorepulsion is the process by which an organism or a cell moves away from a chemical source or in the direction of decreasing concentration of a chemical stimulus. This phenomenon has been observed in a wide variety of systems ranging from the bacterium Escherichia coli to eukaryotic systems such as human white blood cells. The chemical sources or stimuli are known as chemorepellents. While a few experimental studies have been performed on chemorepulsion, no mathematical models of this process exist. In this thesis, we have analysed the first sub-process of chemorepulsionGradient Sensing. Gradient sensing is the mechanism by which information about the external chemical concentration field is communicated to the cell compass which consequently directs the motility machinery of the cell. Gradient sensing is an important aspect of chemorepulsion as it is the first step in determining the direction of eukaryotic cell migration. We have created a mathematical modelling framework that quantitatively describes gradient sensing in Dictyostelium discoideuman experimentally well characterized eukaryotic system and a recognized model system for studies of cell migration. The underlying biochemical pathways of gradient sensing in D. discoideum are described by the biochemical network created by Keizer-Gunnink et al. (2007). We have systematically analysed the effects of different pathways in the Keizer-Gunnink et al. (2007) network in our modelling framework. First, we have extensively analyzed the adaptive response of the cell to various inputs. Next, the roles of the key phosphatidylinositol lipid enzymes and feedback effects in the Keizer-Gunnink et al. (2007) network have been investigated. We have also carefully investigated the receptor regulation of these enzymes in the network. Overall the construction of the modelling framework has enabled us to carefully analyse the individual mechanisms, their interactions and their contributions towards gradient sensing in D. discoideum. The framework has generated testable predictions regarding the role of key components and feedback loops regulating gradient sensing. We have thus taken the first steps towards quantitatively investigating mechanisms underlying chemorepulsive migration in eukaryotic systems.
Effectiveness of different exercises and stretching physiotherapy on pain and movement in patellofemoral pain syndrome: a randomized controlled trial

Objective: To compare the effectiveness of proprioceptive neuromuscular facilitation combined with exercise, classic stretching physiotherapy intervention, and educational intervention at improving patient function and pain in patients with patellofemoral pain syndrome. Design: Randomized, controlled, blind trial over four months. Setting: Urban population, Spain. Participants: Patients undergoing primary care for retropatellar pain. Intervention: Subjects were allocated on three different treatment options: a proprioceptive neuromuscular facilitation and aerobic exercise group, a classic stretching group, and a control treatment were applied over four months under the supervision of a physiotherapist. Main outcome: Knee Society Score, pain reported (Visual analogue scale) and knee range of motion. Assessments were completed at baseline and after four months. Results: 74 patients were enrolled in the study and distributed between groups. Both the proprioceptive neuromuscular facilitation and classic stretching group showed significant changes in all variables after four months intervention (p < 0.001). The difference in mean Kujala knee score changes between groups (classic stretching group vs. proprioceptive neuromuscular facilitation group vs. control group) at four months was −24.05 (95% confidence interval (CI) −30.19, −17.90), p ≤ 0.001; vs. −39.03 (95% confidence interval (CI) −42.5, −35.5), p ≤ 0.001; vs. −0.238 (95% confidence interval (CI) −1.2, 0.726), p = 0.621, respectively. Conclusions: A proprioceptive neuromuscular facilitation intervention protocol combined with aerobic exercise showed a better outcome than a classic stretching protocol after four months.
Donepezil in the treatment of patients with Alzheimer’s disease

Donepezil is the most widely used acetylcholinesterase inhibitor licensed for symptomatic treatment of mild-to-moderate Alzheimer’s disease. Clinical placebo-controlled trials and open-label extension studies have consistently shown that donepezil is well tolerated and gives rise to statistically significant improvements in cognition, global function and activities of daily living for at least 12 months and to less deterioration of function possibly for more than 4 years. Furthermore, donepezil may reduce neuropsychiatric symptoms and caregiver burden. Health economic studies suggest that treatment with donepezil may reduce resource utilization. Evidence-based international management guidelines recommend that treatment with a cholinesterase inhibitor should be considered in all patients with mild-to-moderate Alzheimer’s disease and based on a proper diagnostic evaluation. Treatment cannot replace continuous advice to patients and caregivers.
Overview on ATE Test and Debugging Methods for Asynchronous Circuits

Due to mature design tools and proven flows for design and test the majority of today's circuits are synchronous. Increasingly complex designs pose major problems though with respect to clock tree design, interfaces running at different frequencies, peak current consumption and electromagnetic interference. The asynchronous design style promises advantages in these areas but is not widely accepted, mainly due to the lack of design tool support and testability issues. This paper summarizes the problems regarding the test of asynchronous designs as well as existing test methodologies and presents our strategy to increase testability of this kind of devices.
An adaptive seamless phase II/III design for oncology trials with subpopulation selection using correlated survival endpoints †

Although the statistical methods enabling efficient adaptive seamless designs are increasingly well established, it is important to continue to use the endpoints and specifications that best suit the therapy area and stage of development concerned when conducting such a trial. Approaches exist that allow adaptive designs to continue seamlessly either in a subpopulation of patients or in the whole population on the basis of data obtained from the first stage of a phase II/III design: our proposed design adds extra flexibility by also allowing the trial to continue in all patients but with both the subgroup and the full population as co‐primary populations. Further, methodology is presented which controls the Type‐I error rate at less than 2.5% when the phase II and III endpoints are different but correlated time‐to‐event endpoints. The operating characteristics of the design are described along with a discussion of the practical aspects in an oncology setting. Copyright © 2010 John Wiley & Sons, Ltd.
Transient stability enhancement of power grid by neural network controlled BFCL considering cyber-attacks

In this paper, a neural network predictive controlled bridge type fault current limiter (FCL) is proposed to enhance the transient stability of power systems. Cyber security issues on the performance of neural network controller is also investigated. It is noteworthy that simulations have been conducted by the Matlab/Simulink software. Both symmetrical and unsymmetrical types of permanent and temporary faults have been considered at different locations of a multi-machine power system. Based on the simulation results, it can be concluded that the bridge type FCL based on neural network predictive controller can enhance the transient stability of the system well. Moreover, the cyber-attack has profound effect on the controller performance and the system becomes fully unstable even with the presence of the neural network predictive controlled bridge type FCL.
Omalizumab in the treatment of asthma

Omalizumab was introduced in 2003 and is the first asthma drug to target IgE, the allergic antibody that initiates the allergic cascade. Well-controlled studies and post-marketing clinical experience have shown it to be an effective and safe medication. Treatment guidelines now recommend omalizumab as an add-on option for patients with moderate-to-severe allergic asthma uncontrolled on high-dose inhaled corticosteroids and long-acting β-agonists. Despite initial concerns, there is no evidence of any association with malignancy at this time. In our opinion, omalizumab is well-tolerated and significantly improves pulmonary function, decreases clinical symptoms and improves the quality of life in patients with uncontrolled allergic asthma.