Miracle-dz/UniFAR-FTUs huggingface dataset:
Planejamento do turismo na perspectiva territorial na região extremo sul do RS/Brasil

Com vistas a contribuir para as discussoes na area do planejamento e gestao publica do turismo, no contexto do desenvolvimento regional, este artigo apresenta como objetivo geral analisar a compreensao do territorio por agentes publicos no contexto do planejamento e da gestao do turismo na regiao Extremo Sul do RS. Entende-se a importância do territorio e a valorizacao das particularidades a medida em que se procura dar enfase ao heterogeneo e entender a diversidade regional como potencialidade. A regiao deve ser entendida como particularidade dinâmica, na qual as acoes endogenas presentes no territorio ganham forca. Nesse sentido, observa-se que a regiao Extremo Sul teve, no seu processo de formacao, fatores historicos estruturantes que influenciaram as caracteristicas da regiao, ainda perceptiveis no seu contexto atual. A abordagem teorico-metodologica referenciada no materialismo historico dialetico apoiou-se na pesquisa qualitativa, com enfase no estudo de caso, utilizando a analise de conteudo como procedimento de interpretacao de dados. Observou-se, a partir das entrevistas com os gestores publicos do turismo na regiao, que existe a compreensao de que e preciso atuar de forma regionalizada, contudo a regiao ainda sofre com a falta de protagonismo dos gestores em desenvolver acoes para dinamizar e desenvolver o potencial regional. Por fim, compreender o territorio no contexto do planejamento e gestao do turismo requer buscar respeitar, nas acoes de planejamento, os aspectos que particularizam determinado territorio, ou seja, perceber as particularidades como potencialidades para o turismo.
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

The potassium channel Kv1.3 has recently been located to the inner mitochondrial membrane of lymphocytes. Here, we show that mouse and human cells that are genetically deficient in either Kv1.3 or transfected with siRNA to suppress Kv1.3-expression resisted apoptosis induced by several stimuli, including Bax over-expression. Retransfection of either Kv1.3 or a mitochondrial-targeted Kv1.3 restored cell death. Bax interacted with and functionally inhibited mitochondrial Kv1.3. Incubation of isolated Kv1.3-positive mitochondria with recombinant Bax, t-Bid, or toxins that bind to and inhibit Kv1.3 successively triggered hyperpolarization, formation of reactive oxygen species, release of cytochrome c, and marked depolarization. Kv1.3-deficient mitochondria were resistant to Bax, t-Bid, and the toxins. Mutation of Bax at K128, which corresponds to a conserved lysine in Kv1.3-inhibiting toxins, abrogated its effects on both Kv1.3 and mitochondria. These findings suggest that Bax mediates cytochrome c release and mitochondrial depolarization in lymphocytes, at least in part, via its interaction with mitochondrial Kv1.3.
Entrepreneurial Culture as a Determinant of Nascent Entrepreneurship

This paper develops indicators for entrepreneurial culture and investigates their effect on the rate of nascent entrepreneurship. We choose three measures from the World Value Survey. These include two desired job characteristics, i.e. the opportunity to use initiative and the possibility to achieve something, as well as an indicator of internal locus of control as our indicators for entrepreneurial culture. Controlling for economic, institutional and demographic determinants of nascent entrepreneurship we find a positive and significant relationship between entrepreneurial culture and nascent entrepreneurship.
Early onset of fatty liver in growth‐restricted rat fetuses and newborns

Intrauterine growth‐restricted (IUGR) newborns have increased risk of adult metabolic syndrome, including fatty liver. However, it is unclear whether the fatty liver development is “programmed” or secondary to the accompanying obesity. In this study, we examined hepatic lipid accumulation and lipid‐regulatory factors (sterol regulatory element‐binding protein‐1c and fatty acid synthase) in IUGR and Control fetal (embryonic day 20; e20) and newborn (postnatal day 1; p1) rat pups. Notably, despite of in utero undernutrition state, IUGR fetuses demonstrated “fatty liver” with upregulation of these lipogenic indices at as early as e20. Both IUGR and Control newborns exhibited the same extent of massive increase in hepatic lipid content, whereas IUGR newborns continued to exhibit upregulated lipogenic indices. The persistent upregulation of the lipogenic indices in fetal and newborn IUGR suggests that fatty liver is gestationally programmed. Our study suggested that IUGR offspring were born with an altered metabolic life strategy of increased fuel/lipid storage which could be a distinct metabolic pathway of the thrifty phenotype.
Survey of analysis of user behavior in online social network

Online social networking is growing fast with a full range of service that is available for massive number of users to share opinions and interests, express emotions and keep in touch with friends. The community is becoming increasing connected to each other. Many online sites provide a number of ways to access the site using devices such as computers and smart phones. Thus, users can use their sites quickly and easily, anytime and anywhere. This survey focused on the process of classifying online social network users and reviews various methods to analyze user behavior in online social networks.
Data Mining as Support to Knowledge Management in Marketing

Abstract Background: Previous research has shown success of data mining methods in marketing. However, their integration in a knowledge management system is still not investigated enough. Objectives: The purpose of this paper is to suggest an integration of two data mining techniques: neural networks and association rules in marketing modeling that could serve as an input to knowledge management and produce better marketing decisions. Methods/Approach: Association rules and artificial neural networks are combined in a data mining component to discover patterns and customers’ profiles in frequent item purchases. The results of data mining are used in a web-based knowledge management component to trigger ideas for new marketing strategies. The model is tested by an experimental research. Results: The results show that the suggested model could be efficiently used to recognize patterns in shopping behaviour and generate new marketing strategies. Conclusions: The scientific contribution lies in proposing an integrative data mining approach that could present support to knowledge management. The research could be useful to marketing and retail managers in improving the process of their decision making, as well as to researchers in the area of marketing modelling. Future studies should include more samples and other data mining techniques in order to test the model generalization ability.
Measurement of elastic forces between iron colloidal particles in a nematic liquid crystal.

The forces that arise between two iron particles in a nematic liquid crystal with a strong homeotropic anchoring were studied. For the first time, the short range repulsive force resulting from the presence of a hedgehog defect between two particles was precisely determined thanks to application of a small magnetic field and observation of the equilibrium position resulting from the balance between the elastic and magnetic forces. Above a given threshold force, the particles stuck together whereas the hedgehog defect was expelled and transformed into a Saturn ring located between the particles. The attractive part of the interparticle force was determined with the same method on the entire range of separation distances; we found that the equilibrium distance between two particles was r = 1.19 +/- 0.05 ( was the average diameter of the pair of particles).
Coal dust exposure and mortality from ischemic heart disease among a cohort of U.S. coal miners.

BACKGROUND Particulate exposure from air pollution increases the risk of ischemic heart disease (IHD) mortality. Although coal miners are highly exposed to coal dust particulate, studies of IHD mortality risk among coal miners have had inconsistent results. Previous studies may have been biased by the healthy worker effect. METHODS We examined the dose-response relationship between cumulative coal dust exposure, coal rank, and IHD mortality among a cohort of underground coal miners who participated in the National Study of Coal Workers' Pneumoconiosis. RESULTS After adjusting for age, smoking, and body mass index, risk of IHD mortality increased at higher levels of coal dust exposure. Mortality risk was also associated with coal rank region. CONCLUSION There was an increased risk of mortality from IHD associated with cumulative exposure to coal dust, and with coal rank. The effect of coal rank may be due differences in the composition of coal mine dust particulate. The association of risk of IHD mortality with cumulative particulate exposure is consistent with air pollution studies.
Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors

FcγRs are key regulators of the immune response, capable of binding to the Fc portion of IgG Abs and manipulating the behavior of numerous cell types. Through a variety of receptors, isoforms, and cellular expression patterns, they are able to fine-tune and direct appropriate responses. Furthermore, they are key determinants of mAb immunotherapy, with mAb isotype and FcγR interaction governing therapeutic efficacy. Critical to understanding the biology of this complex family of receptors are reagents that are robust and highly specific for each receptor. In this study, we describe the development and characterization of mAb panels specific for both mouse and human FcγR for use in flow cytometry, immunofluorescence, and immunocytochemistry. We highlight key differences in expression between the two species and also patterns of expression that will likely impact on immunotherapeutic efficacy and translation of therapeutic agents from mouse to clinic.
What Moves Parties?

Do Western European political parties adjust their ideological positions in response to shifts in public opinion and to changing global economic conditions? Based on a time-series, cross-sectional analysis of parties' ideological dynamics in eight Western European democracies from 1976-1998, the authors conclude that both factors influence parties' ideological positions but that this relationship is mediated by the type of party. Specifically, they find that parties of the center and right react to both public opinion and the global economy, whereas parties of the left display no discernible tendency to respond to public opinion and also appear less responsive to global economic conditions. The findings on leftist parties' distinctiveness support arguments about these parties' long-term policy orientations as well as about their organizational structures. The authors also find little support for neoliberal convergence arguments.
Phase identification of individual crystalline particles by electron backscatter diffraction

Recently, an electron backscatter diffraction (EBSD) system was developed that uses a 1024 × 1024 CCD camera coupled to a thin phosphor. This camera has been shown to produce excellent EBSD patterns. In this system, crystallographic information is determined from the EBSD pattern and coupled with the elemental information from energy or wavelength dispersive X‐ray spectrometry. Identification of the crystalline phase of a sample is then made through a link to a commercial diffraction database. To date, this system has been applied almost exclusively to conventional, bulk samples that have been polished to a flat surface. In this investigation, we report on the application of the EBSD system to the phase identification analysis of individual micrometre and submicrometre particles rather than flat surfaces.
Analysis of available cloud computing models to support cloud adoption decision process in an enterprise

Cloud Computing (CC) is a technology that surely brings innovations in today's business world, more and more companies around the world are widely incorporating this technology into their businesses. From a technical, as well as organizational point of view transferring enterprise IT to the Cloud is a complex task. Different factors have to be taken into consideration in order to make a right choice when moving IT services to the Cloud. The goal of this paper is to identify all factors that influence organization's decision to adopt Cloud and its return on investment (ROI). Cloud providers offer different types of services. In this paper we discuss advantages and disadvantages of different Cloud Computing services, with the goal of helping organizations fully understand Cloud adoption and its success potentials. General model for Cloud adoption decision process, in an enterprise, is presented and it consists of the key factors driving the organizational benefits when moving to the Cloud. Multi-criteria decision making methods are presented as one of the key factors.
Perceptual analyses of spasmodic dysphonia before and after treatment.

OBJECTIVE To evaluate expert listeners' perceptions of voice and fluency in persons with adductor spasmodic dysphonia (ADSD) before and after treatment with botulinum toxin type A (Botox), as a function of initial severity of the disorder (while controlling for patients' age at injection). DESIGN Simple before-and-after trial with blinded randomized listener judgments. SETTING Ambulatory care clinic at a single medical center. PARTICIPANTS Forty-two consecutive patients with ADSD who underwent examination, with a 3- to 6-week follow-up, after initial botulinum toxin type A injection. There were also 42 age- and sex-matched healthy control subjects. INTERVENTIONS Injections of botulinum toxin type A into the thyroarytenoid muscle(s). MAIN OUTCOME MEASURES Computer-implemented visual analog scaling judgments of voice quality and speech fluency made by expert listeners under psychoacoustically controlled conditions. RESULTS Response to botulinum toxin type A varied markedly as a function of pretreatment severity of ADSD. More severe initial symptoms exhibited greater magnitudes of improvement. Patients with mild dysphonia did not exhibit pretreatment to posttreatment change. Following treatment, voice and fluency remained significantly (P<.05) poorer in ADSD than in healthy speakers. Older patients exhibited less improvement than younger patients when the effect of initial severity was statistically controlled. CONCLUSIONS Voice quality and fluency improved for most patients following treatment, but older patients and those with milder dysphonia exhibited the least optimal responses to the procedure. Patients who were profoundly impaired demonstrated the greatest amount of improvement. Computer-implemented visual analog scaling provided a reliable clinical tool for determining treatment-related changes in those with ADSD.
Five-phase induction machine parameter identification using PSO and standstill techniques

Multiphase variable-speed drives' advantages such as fault tolerance and better power-per-phase splitting make these electromagnetic devices suitable for high reliability applications. However, the applied control techniques require accurate knowledge of the electrical parameters of the machine. Although a large number of modulation and control strategies have been proposed, little work has been focused on the estimation of these parameters. This paper proposes an off-line procedure to estimate the parameters of five-phase induction machines. The proposed method is based on standstill time-domain tests and the particle swarm optimization (PSO) technique, and it can be easily extended to any number of phases.
High-dose chemotherapy with autologous hematopoietic progenitor-cell support as part of combined modality therapy in patients with inflammatory breast cancer.

PURPOSE To evaluate the feasibility of high-dose chemotherapy (HDC) with autologous hematopoietic progenitor-cell support (AHPCS) as part of combined modality therapy (CMT) in patients with inflammatory breast cancer (IBC). PATIENTS AND METHODS From April 1993 to March 1997, 30 patients with IBC were treated at our program. Twenty-three patients received neoadjuvant chemotherapy (NAC) before HDC; 18 patients also received adjuvant chemotherapy following surgery, but before HDC. All patients received HDC with high-dose cyclophosphamide, cisplatin, and carmustine (BCNU) with AHPCS. Every patient underwent surgery either before (27 patients) or after (three patients) HDC. Patients received radiotherapy after HDC in addition to tamoxifen if their tumors were estrogen receptor-positive. RESULTS Thirteen patients experienced grade 3 or 4 nonhematologic noninfectious toxicities. In 12 patients (40%), this represented drug-induced lung injury, which in all cases responded to a 10-week course of corticosteroids. The only treatment-related death was secondary to hemolytic-uremic syndrome (HUS). Another patient suffered grade 4 CNS toxicity, which was completely reversible. All patients engrafted promptly. Eight patients relapsed, five of whom had a poor pathologic response to NAC. Relapses were local (five patients), local plus systemic (one), or systemic only (two). Median follow-up time from diagnosis and HDC is 23.5 (range, 7 to 49) and 19 (range, 4 to 44) months, respectively. Twenty-one patients (70%; 95% confidence interval [CI], 51% to 86%) remain alive and free of disease 4 to 44 months after HDC. Median disease-free survival (DFS) and overall survival have not yet been reached. CONCLUSION HDC as part of CMT is feasible in patients with IBC. The toxicity of this treatment program is significant, but tolerable. Despite the short follow-up duration, the promising DFS observed in this group of patients warrants randomized studies that include a HDC-containing arm in patients with IBC.
The effects of dexamethasone on plasma steroid levels and fetal adrenal histology in the pregnant rhesus monkey.

Dexamethasone (8 mg/day im) has been administered to rhesus monkeys (Macaca mulatto) from days 146–156 of pregnancy, until term. This treatment was ineffective in precipitating premature delivery, and the monkeys delivered spontaneously at the expected time (day 166–176). Maternal peripheral plasma progesterone concentrations were unaffected by the dexamethasone treatment. However, administration of the synthetic glucocorticoid resulted in a marked suppression of the maternal plasma estrone and estradiol-17β concentrations in all animals. In the 4 monkeys in which injections of dexamethasone were initiated earliest (days 146–150), the plasma unconjugated estrogen levels at term were 15–40% of those found prior to the start of treatment. At autopsy, the adrenal glands from the fetuses of dexamethasone-treated monkeys had markedly atrophied, and showed appreciable regression of the fetal zone. It is suggested that dexamethasone crosses the placenta and inhibits fetal ACTH release, resulting in regression of.
Regional fibrocartilage variations in human anterior cruciate ligament tibial insertion: a histological three-dimensional reconstruction

Abstract Purpose: We studied anterior cruciate ligament (ACL) tibial insertion architecture in humans and investigated regional differences that could suggest unequal force transmission from ligament to bone. Materials and methods: ACL tibial insertions were processed histologically. With Photoshop software, digital images taken from the histological slides were collaged, contour lines were drawn, and different gray values were filled based on the structure. The data were exported to Amira software for three-dimensional reconstruction. Results: The uncalcified fibrocartilage (UF) layer was divided into three regions: lateral, medial and posterior according to the architecture. The UF zone was significantly thicker laterally than medially or posteriorly (p < 0.05). Similarly, the calcified fibrocartilage (CF) thickness was significantly greater in the lateral part of the enthesis compared to the medial and posterior parts (p < 0.05). Conclusions: The UF quantity (more UF laterally) corresponding to the CF quantity (more CF laterally) at the ACL tibial insertion provides further evidence suggesting that the load transferred from the ACL to the tibia was greater laterally than medially and posteriorly.
Adaptive single snapshot beamforming: a new concept for the rejection of nonstationary and coherent interferers

An approach to adaptive beamforming (adaptive reconstruction of a desired signal in the presence of interferers and noise) that uses just a single snapshot to calculate the antenna weights is presented. As in previous studies, a structured and grouped array of sensor elements is assumed. The concept exploits the induced special data structure, which can be described as a generalized rank-one eigenvalue problem and can be solved by means of a linear (overdetermined) system solver. Arbitrary signal statistics are allowed and no difficulties with nonstationary, and coherent interferers arise. Furthermore, the algorithm does not exhibit any transient behavior. Simulations verify its good performance in comparison with the optimum beamformer. >
Coincidence Detection: Towards an alternative to Synaptic Plasticity

Coincidence Detection: Towards an alternative to Synaptic Plasticity Francis Jeanson Carleton University Abstract: Memory and learning are believed to be neurally based on a general class of processes known as synaptic plasticity (Kandel et al., 2000). Working memory, however, is arguably too fast to rely solely on synaptic weighting and must instead take place as an active neural process (O’Reilly & Manukata, 2000). I propose that active processes, which can account for both simple stimulus based memories as well as simple associations, can be instantiated within populations of highly interconnected neurones that exploit the precise timing of spikes; I call these ”firing-chains”. ˆ firing-chains exist over time period T, suggesting that many In a population of N neurones a maximum of T*2 N more firing-chains than neurones or connections exist. I aim to show how self-sustaining firing-chains can implement simple memories, but also that simple associations between two or more firing-chains can be made if their joint simultaneous activity triggers a new firing-chain.
Excavations at Christ Church, Spitalfields 1984–6

The Spitalfields project, now moving from the field to laboratory analysis, takes the archaeological study of human burial into new areas. The preliminary results, reported here, have importance for the archaeology of Christian death and – beyond that – for wider questions in mortuary study and inference from skeletal remains and their disposition.