Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma.

PURPOSE To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma. PATIENTS AND METHODS Patients with recurrent glioblastoma were treated with bevacizumab 10 mg/kg every 2 weeks. After tumor progression, patients were immediately treated with bevacizumab in combination with irinotecan 340 mg/m(2) or 125 mg/m(2) every 2 weeks, depending on use of enzyme-inducing antiepileptic drugs. Complete patient evaluations were repeated every 4 weeks. RESULTS Forty-eight heavily pretreated patients were accrued to this study. Thromboembolic events (12.5%), hypertension (12.5%), hypophosphatemia (6%), and thrombocytopenia (6%) were the most common drug-associated adverse events. Six patients (12.5%) were removed from study for drug-associated toxicity (five thromboembolic events, one bowel perforation). Thirty-four patients (71%) and 17 patients (35%) achieved radiographic response based on Levin and Macdonald criteria, respectively. Median progression-free survival (PFS) was 16 weeks (95% CI, 12 to 26 weeks). The 6-month PFS was 29% (95% CI, 18% to 48%). The 6-month overall survival was 57% (95% CI, 44% to 75%). Median overall survival was 31 weeks (95% CI, 21 to 54 weeks). Early magnetic resonance imaging response (first 96 hours and 4 weeks) was predictive of long-term PFS, with the Levin criteria being more predictive than Macdonald criteria. Of 19 patients treated with bevacizumab plus irinotecan at progression, there were no objective radiographic responses. Eighteen patients (95%) experienced disease progression by the second cycle, and the median PFS was 30 days. CONCLUSION We conclude that single-agent bevacizumab has significant biologic and antiglioma activity in patients with recurrent glioblastoma.
Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma

Abstract NKL homeobox gene MSX1 is physiologically expressed during embryonic hematopoiesis. Here, we detected MSX1 overexpression in three examples of mantle cell lymphoma (MCL) and one of acute myeloid leukemia (AML) by screening 96 leukemia/lymphoma cell lines via microarray profiling. Moreover, in silico analysis identified significant overexpression of MSX1 in 3% each of patients with MCL and AML, confirming aberrant activity in subsets of both types of malignancies. Comparative expression profiling analysis and subsequent functional studies demonstrated overexpression of histone acetyltransferase PHF16 together with transcription factors FOXC1 and HLXB9 as activators of MSX1 transcription. Additionally, we identified regulation of cyclin D1/CCND1 by MSX1 and its repressive cofactor histone H1C. Fluorescence in situ hybridization in MCL cells showed that t(11;14)(q13;q32) results in detachment of CCND1 from its corresponding repressive MSX1 binding site. Taken together, we uncovered regulators and targets of homeobox gene MSX1 in leukemia/lymphoma cells, supporting the view of a recurrent genetic network that is reactivated in malignant transformation.
Semi‐supervised Mesh Segmentation and Labeling

Recently, approaches have been put forward that focus on the recognition of mesh semantic meanings. These methods usually need prior knowledge learned from training dataset, but when the size of the training dataset is small, or the meshes are too complex, the segmentation performance will be greatly effected. This paper introduces an approach to the semantic mesh segmentation and labeling which incorporates knowledge imparted by both segmented, labeled meshes, and unsegmented, unlabeled meshes. A Conditional Random Fields (CRF) based objective function measuring the consistency of labels and faces, labels of neighbouring faces is proposed. To implant the information from the unlabeled meshes, we add an unlabeled conditional entropy into the objective function. With the entropy, the objective function is not convex and hard to optimize, so we modify the Virtual Evidence Boosting (VEB) to solve the semi‐supervised problem efficiently. Our approach yields better results than those methods which only use limited labeled meshes, especially when many unlabeled meshes exist. The approach reduces the overall system cost as well as the human labelling cost required during training. We also show that combining knowledge from labeled and unlabeled meshes outperforms using either type of meshes alone.
Alternative calendars and memory work in Serbia: Anti-war activism after Milošević

This article analyzes the continuation of anti-war groups and activists in Serbia who were in opposition to wars in the 1990s and, in the decade after October 2000, are still in struggle. Activism often analyzed as part of the “Dealing with the Past Projects” is here analyzed in the context of social memory studies contributing to the understanding of current memory work and memory activism in Serbia. Drawing on Eviatar Zerubavel’s analysis of calendars as sites of social organization of national memory, this text looks at the emergence of alternative calendars as formed and created by anti-war and human rights activists. By analyzing the emerging alternative civic calendar in Serbia, I discuss memory activism as related to the commemoration of the Siege of Sarajevo and the Omarska concentration camp. I then extend my analysis on what I see as the most apparent and significant day on the emerging civic alternative calendar: 10 July annual commemoration of the victims of Srebrenica taking place for the last two decades at the heart of Belgrade’s city center, Republic Square.
Verbal Processes on Psychological Radio Call-In Programs: Comparisons With Other Help-Intended Interactions

We describe the verbal process of program hosts and callers during call-in psychology interviews; we measured the similarity of these interactions with other help-intended interactions, and we assessed the compatibility of hosts' verbal behavior with prescribed ethical guidelines. Radio interviews with 30 callers were recorded from each of 6 programs broadcast in major American cities. Hosts' and callers' verbal response modes (VRMs) were coded and compared with the VRMs used in psychotherapy, university settings, and medical interviews. Hosts' VRMs most resembled those of rationalemotive therapists and those of physicians in the conclusion segment of medical interviews. Callers' VRMs most resembled those of clients in cognitive-behavioral therapy. The results call into question the viability of the distinctions made in current ethical guidelines governing psychologists' behavior on such programs. The emergence of call-in radio programs as a popular source of entertainment, personal advice, and psychological information has inspired a new subdiscipline within psychology: radio psychology (Bouhoutsos, Goodchilds, & Huddy, 1986). In addition to its enthusiastic public response, radio psychology has found support within the professional establishment. In 1982 the Association for Media Psychology (AMP) was formed, and in 1987 media psychology was granted division status (Division 46) in the American Psychological Association (APA). Although several authors have discussed call-in programs (Baiter, 1983; Bouhoutsos, 1983a, 1983b; Bouhoutsos et al., 1986; Klonoff, 1983; Raviv, Raviv, & Yunovitz, 1989; Ruben, 1986; Rubenstein, 1981; Schwebel, 1982; Wober, 1978), few reWILLIAM H. HENRICKS received his MA from Miami University in 1988. He is currently a doctoral candidate in Miami University's clinical psychology program and is a psychology intern at Emerson A. North Hospital, Cincinnati, Ohio, where he conducts group psychotherapy and psychodiagnostic assessments. His research interests include verbal interaction processes, depression, and posttraumatic stress disorder. WILLIAM B. STILES received his PhD in clinical psychology from the University of California, Los Angeles, in 1972. He is currently a professor of psychology at Miami University and is the director of the psychology clinic. His research interests include verbal interaction processes. PORTIONS OF THIS ARTICLE were presented at the annual convention of the American Psychological Association in Atlanta, Georgia, in August
Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: Differential inputs to the anterior versus posterior subregions

The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to mediate many of its functions. Previous work showed that vesicular glutamate transporters (VGluTs; specific markers for glutamatergic neurons) are expressed in forebrain sites that project to the PVN; however, the extent of this presumed glutamatergic innervation to the PVN is not clear. In the present study retrograde FluoroGold (FG) labeling of PVN‐projecting neurons was combined with in situ hybridization for VGluT1 and VGluT2 mRNAs to identify forebrain regions that provide glutamatergic innervation to the PVN and its immediate surround in rats, with special consideration for the sources to the anterior versus posterior PVN. VGluT1 mRNA colocalization with retrogradely labeled FG neurons was sparse. VGluT2 mRNA colocalization with FG neurons was most abundant in the ventromedial hypothalamus after anterior PVN FG injections, and in the lateral, posterior, dorsomedial, and ventromedial hypothalamic nuclei after posterior PVN injections. Anterograde tract tracing combined with VGluT2 immunolabeling showed that 1) ventromedial nucleus‐derived glutamatergic inputs occur in both the anterior and posterior PVN; 2) posterior nucleus‐derived glutamatergic inputs occur predominantly in the posterior PVN; and 3) medial preoptic nucleus‐derived inputs to the PVN are not glutamatergic, thereby corroborating the innervation pattern seen with retrograde tracing. The results suggest that PVN subregions are influenced by varying amounts and sources of forebrain glutamatergic regulation, consistent with functional differentiation of glutamate projections. J. Comp. Neurol. 519:1301–1319, 2011. © 2010 Wiley‐Liss, Inc.
Negotiating the Ethics of Care and Justice

This article explores the competing demands imposed by the ethics of care and justice in an urban high school. Beginning with theoretical constructs of each ethic, the author contrasts care and justice as ideal types and discusses the tensions in educational administration around negotiating the two ethics. Presenting the specific case of a multiethnic urban high school grappling with attendance and truancy problems, the author describes the various perspectives of students, teachers, administrators, and staff members with respect to their school as caregiving and justice seeking. The findings of the study suggest that school members negotiate, rather than reconcile, the ethics of care and justice in actual practice.
A comparison of the TRCII and latex-particle tests for the titration of FR-antigen

The great convenience of a method using a suspension of antibody-coated latex particles for the titration of fibrinogen-related antigens over the tanned red cell haemaglutination immunoassay (TRCHII test) of Merskey, Lalezari, and Johnson (1969) has been demonstrated. The usefulness of Ca-Ancrod for the defibrination of heparinized plasma is presented here.
Global inverse kinematics via mixed-integer convex optimization

In this paper, we present a novel formulation of the inverse kinematics (IK) problem with generic constraints as a mixed-integer convex optimization program. The proposed approach can solve the IK problem globally with generic task space constraints: a major improvement over existing approaches, which either solve the problem in only a local neighborhood of the user initial guess through nonlinear non-convex optimization, or address only a limited set of kinematics constraints. Specifically, we propose a mixed-integer convex relaxation of non-convex SO ( 3 ) rotation constraints, and apply this relaxation on the IK problem. Our formulation can detect if an instance of the IK problem is globally infeasible, or produce an approximate solution when it is feasible. We show results on a seven-joint arm grasping objects in a cluttered environment, an 18-degree-of-freedom quadruped standing on stepping stones, and a parallel Stewart platform. Moreover, we show that our approach can find a collision free path for a gripper in a cluttered environment, or certify such a path does not exist. We also compare our approach against the analytical approach for a six-joint manipulator. The open-source code is available at http://drake.mit. edu .
Osteopontin in Patients with Primary Knee Osteoarthritis : Relation to Disease Severity

Background: Osteopontin; a small integrin-binding ligand; has been proved to be an important factor in bone mineralization, remodeling and metabolism. Upregulation of osteopontin was noticed in knee osteoarthritis. It may be involved in the molecular pathogenesis of the disease, contributing to progressive degeneration of articular cartilage. Aim: To measure plasma and synovial fluid osteopontin in patients with primary knee osteoarthritis in order to assess its relation to disease severity. Patients and Methods: This study included thirty patients (aged 44-66 years) diagnosed as having primary knee osteoarthritis according to the checklist of American College of Rheumatology criteria. Ten age and sex matched apparently healthy controls were also enrolled in this study. Full history taking, thorough clinical examination, routine laboratory investigations,and plasma osteopontin (OPN) level measurement were done for all patients and controls. While Synovial fluid OPN levels were measured in cases with knee effusion. Disease severity was assessed using Kellgren/ Lawrence (K/L) radiological score. Results: Statistically significantly elevated levels of both plasma and synovial fluid OPN were found in patients compared to controls (P<0.001&P<0.05 respectively). Synovial fluid OPN levels were statistically significantly higher than paired plasma samples (P<0.001). A significant positive correlation was found between plasma OPN and synovial fluid OPN levels and both of them showed positive correlation with disease severity grades as assessed by K/L radiological score. In Conclusion: Both plasma and synovial fluid OPN levels were increased in primary knee O.A patients and both of them correlated with more severe OA. Measurements of plasma and/or synovial fluid levels of osteopontin could possibly serve as a biochemical parameter for determining disease severity and predicting the progression of osteoarthritic disease process. [Hanan Elsebaie, Hebatallah A. Elchamy, Eman A.Kaddah and Ramy G.Abdelfattah. Osteopontin in Patients with Primary Knee Osteoarthritis: Relation to Disease Severity] Life Sci. J., 2012; 9(4):3902-3909]. (ISSN: 10978135). http://www.lifesciencesite. com. 581
The Effective Product Placement: Finding Appropriate Methods and Contexts for Higher Brand Salience

Notwithstanding the little understanding on the product placement in movies, practitioners have misbelieved that this marketing activity eventually generates favorable attitudes toward their products/brands exposed in movies; likewise, research on product placement tends to perpetuate the practicality of the practice by using improper measures for the effectiveness of product placement. By designing a novel experiment and creating a measure for brand salience as an outcome of product placement, this article entails distinct research findings. In order to achieve a higher brand salience, product placements need to be either demonstrative or placed in negative context. Future research may contribute further by inventing an experiment design enabling researchers to grasp the interaction effects of different factors addressed in the study.
6-Phosphogluconate dehydratase deficiency in pleiotropic carbohydrate-negative mutant strains of Pseudomonas aeruginosa

Mutants of Pseudomonas aeruginosa, strain PAO, have been isolated that are unable to grow on mannitol, glucose, gluconate, or 2-ketogluconate, cut that exhibit wild-type growth on pyruvate, lactate, citrate, succinate, or acetate. Although some of these mutants were also unable to grow on glycerol, the mutations formed a single linkage group by quantitative transductional analysis with phage F116 on glucose minimal agar medium. Cell extracts of all mutant strains were either lacking or severely deficient in 6-phosphogluconate dehydratase activity. Glu+ transductants derived from mutant strains that retained the wild-type ability for growth at the expense of glycerol also regained the ability to grow on all C-6 compounds. Although a role for the pentose phosphate pathway in the catabolism of C6 substrates was not found, a functional Entner-Doudoroff pathway appears to be essential for the catabolism of mannitol, glucose, gluconate, and 2-ketogluconate.
Languages of art : an approach to a theory of symbols

"Like Dewey, he has revolted against the empiricist dogma and the Kantian dualisms which have compartmentalized philosophical thought.Unlike Dewey, he has provided detailed incisive argumentation, and has shown just where the dogmas and dualisms break down. " -- Richard Rorty, The Yale Review
Adolescent Temperament Moderates the Relation of Parenting to Antisocial Behavior and Substance Use

Although some studies have found that parental support and control are related negatively to adolescent problem behaviors, little research has examined factors that may qualify the magnitude of those relations. The present study tests whether adolescent temperament moderates the relations of parenting to antisocial behavior and substance use within a community sample (N = 631). The joint and unique contributions of parenting and temperament in the prediction of those problem behaviors were also examined in this study. Results indicate that parenting and temperament evidenced significant joint and unique relations with adolescent antisocial behavior and substance use. Furthermore, temperament moderated the relations between parenting and adolescent problem behaviors, wherein parenting showed stronger relations with antisocial behavior and substance use at higher levels of temperamental risk. The findings supported the contention that individual differences moderate the relations between parenting and problem behaviors and indicate several directions forfuture research.
An Interaction Framework of Consumer Decision Making

Three streams of research on consumer decision processes—task characteristics, individual differences, and elemental behavioral response analysis—are integrated within the conceptual framework of an interactionist model of consumer decision making. Taxonomies of task and individual difference characteristics are presented. It is suggested that a complete model of the consumer choice process must explicitly consider three components: task, individual difference, and task × individual difference interactions.
Efficient adaptation of complex-valued noiselet sensing matrices for compressed single-pixel imaging

Minimal mutual coherence of discrete noiselets and Haar wavelets makes this pair of bases an essential choice for the measurement and compression matrices in compressed-sensing-based single-pixel detectors. In this paper, we propose an efficient way of using complex-valued and nonbinary noiselet functions for object sampling in single-pixel cameras with binary spatial light modulators and incoherent illumination. The proposed method allows us to determine m complex noiselet coefficients from m+1 binary sampling measurements. Further, we introduce a modification to the complex fast noiselet transform, which enables computationally efficient real-time generation of the binary noiselet-based patterns using efficient integer calculations on bundled patterns. The proposed method is verified experimentally with a single-pixel camera system using a binary spatial light modulator.
Multi-library coded caching

We study the problem of coded caching when the server has access to several libraries and each user makes independent requests from every library. The single-library scenario has been well studied and it has been proved that coded caching can significantly improve the delivery rate compared to uncoded caching. In this work we show that when all the libraries have the same number of files, memory-sharing is optimal and the delivery rate cannot be improved via coding across files from different libraries. In this setting, the optimal memory-sharing strategy is one that divides the cache of each user proportional to the size of the files in different libraries. As for the general case, when the number of files in different libraries are arbitrary, we propose an inner-bound based on memory-sharing and an outer-bound based on concatenation of files from different libraries.
Gene expression profiling of replicative and induced senescence

Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism. Senescence can be a result of telomere shortening (natural or replicative senescence) or DNA damage resulting from exogenous stressors (induced senescence). Here, we performed gene expression profiling through RNA-seq of replicative senescence, adriamycin-induced senescence, H2O2-induced senescence, and 5-aza-2-deoxycytidine-induced senescence in order to profile the pathways controlling various types of senescence. Overall, the pathways common to all 4 types of senescence were related to inflammation and the innate immune system. It was also evident that 5-aza-induced senescence mirrors natural replicative senescence due to telomere shortening. We also examined the prevalence of senescence-associated secretory phenotype (SASP) factors in the RNA-seq data, showing that it is a common characteristic of all 4 types of senescence. In addition, we could discriminate changes in gene expression due to quiescence during cellular senescence from those that were specific to senescence.
Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations*

Mitochondria extrude protons across their inner membrane to generate the mitochondrial membrane potential (ΔΨm) and pH gradient (ΔpHm) that both power ATP synthesis. Mitochondrial uptake and efflux of many ions and metabolites are driven exclusively by ΔpHm, whose in situ regulation is poorly characterized. Here, we report the first dynamic measurements of ΔpHm in living cells, using a mitochondrially targeted, pH-sensitive YFP (SypHer) combined with a cytosolic pH indicator (5-(and 6)-carboxy-SNARF-1). The resting matrix pH (∼7.6) and ΔpHm (∼0.45) of HeLa cells at 37 °C were lower than previously reported. Unexpectedly, mitochondrial pH and ΔpHm decreased during cytosolic Ca2+ elevations. The drop in matrix pH was due to cytosolic acid generated by plasma membrane Ca2+-ATPases and transmitted to mitochondria by Pi/H+ symport and K+/H+ exchange, whereas the decrease in ΔpHm reflected the low H+-buffering power of mitochondria (∼5 mm, pH 7.8) compared with the cytosol (∼20 mm, pH 7.4). Upon agonist washout and restoration of cytosolic Ca2+ and pH, mitochondria alkalinized and ΔpHm increased. In permeabilized cells, a decrease in bath pH from 7.4 to 7.2 rapidly decreased mitochondrial pH, whereas the addition of 10 μm Ca2+ caused a delayed and smaller alkalinization. These findings indicate that the mitochondrial matrix pH and ΔpHm are regulated by opposing Ca2+-dependent processes of stimulated mitochondrial respiration and cytosolic acidification.