Miracle-dz/UniFAR-FTUs huggingface dataset:
Pseudotyped Influenza A Virus as a Vaccine for the Induction of Heterotypic Immunity

ABSTRACT There is a need for vaccines that can protect broadly across all influenza A strains. We have produced a pseudotyped influenza virus based on suppression of the A/PR/8/34 hemagglutinin signal sequence (S-FLU) that can infect cells and express the viral core proteins and neuraminidase but cannot replicate. We show that when given by inhalation to mice, S-FLU is nonpathogenic but generates a vigorous T cell response in the lung associated with markedly reduced viral titers and weight loss after challenge with H1 and H3 influenza viruses. These properties of S-FLU suggest that it may have potential as a broadly protective A virus vaccine, particularly in the setting of a threatened pandemic before matched subunit vaccines become available.
Combinatorial principles weaker than Ramsey's Theorem for pairs

Abstract We investigate the complexity of various combinatorial theorems about linear and partial orders, from the points of view of computability theory and reverse mathematics. We focus in particular on the principles ADS (Ascending or Descending Sequence), which states that every infinite linear order has either an infinite descending sequence or an infinite ascending sequence, and CAC (Chain-AntiChain), which states that every infinite partial order has either an infinite chain or an infinite antichain. It is wellknown that Ramsey's Theorem for pairs () splits into a stable version () and a cohesive principle (COH). We show that the same is true of ADS and CAC, and that in their cases the stable versions are strictly weaker than the full ones (which is not known to be the case for and ). We also analyze the relationships between these principles and other systems and principles previously studied by reverse mathematics, such as WKL0, DNR, and BΣ2. We show, for instance, that WKL0 is incomparable with all of the systems we study. We also prove computability-theoretic and conservation results for them. Among these results are a strengthening of the fact, proved by Cholak, Jockusch, and Slaman, that COH is -conservative over the base system RCA0. We also prove that CAC does not imply DNR which, combined with a recent result of Hirschfeldt, Jockusch. Kjos-Hanssen, Lempp, and Slaman, shows that CAC does not imply (and so does not imply ). This answers a question of Cholak, Jockusch, and Slaman. Our proofs suggest that the essential distinction between ADS and CAC on the one hand and on the other is that the colorings needed for our analysis are in some way transitive. We formalize this intuition as the notions of transitive and semitransitive colorings and show that the existence of homogeneous sets for such colorings is equivalent to ADS and CAC, respectively. We finish with several open questions.
Event-related brain potentials to emotional images and gonadal steroid hormone levels in patients with schizophrenia and paired controls

Prominent disturbances in the experience, expression, and emotion recognition in patients with schizophrenia have been relatively well documented over the last few years. Furthermore, sex differences in behavior and brain activity, associated with the processing of various emotions, have been reported in the general population and in schizophrenia patients. Others proposed that sex differences should be rather attributed to testosterone, which may play a role in the etiology of schizophrenia. Also, it had been suggested that estradiol may play a protective role in schizophrenia. Surprisingly, few studies investigating this pathology have focused on both brain substrates and gonadal steroid hormone levels, in emotional processing. In the present study, we investigated electrocortical responses related to emotional valence and arousal as well as gonadal steroid hormone levels in patients with schizophrenia. Event-Related Potentials (ERP) were recorded during exposition to emotional pictures in 18 patients with schizophrenia and in 24 control participants paired on intelligence, manual dominance and socioeconomic status. Given their previous sensitivity to emotional and attention processes, the P200, N200 and the P300 were selected for analysis. More precisely, emotional valence generally affects early components (N200), which reflect early process of selective attention, whereas emotional arousal and valence both influences the P300 component, which is related to memory context updating, and stimulus categorization. Results showed that, in the control group, the amplitude of the N200 was significantly more lateralized over the right hemisphere, while there was no such lateralization in patients with schizophrenia. In patients with schizophrenia, significantly smaller anterior P300 amplitude was observed to the unpleasant, compared to the pleasant. That anterior P300 reduction was also correlated with negative symptoms. The N200 and P300 amplitudes were positively correlated with the estradiol level in all conditions, revealing that the N200 and the P300 were reduced, when estradiol level was higher. Conversely, only the P300 amplitude showed positive correlation with the testosterone level.
Observer-based and energy saving control of single-rod electro-hydraulic servo system driven by servo motor

This paper addresses the energy saving problem in single-rod electro-hydraulic servo system (EHSS) driven by servo motor. Firstly, the performance of key components in EHSS is analyzed and tested locally and globally to pursue better control effect. Then, an energy saving controller containing three control variables is proposed. The servo valve controller is designed based on ARC to guarantee a prescribed output tracking transient performance and final tracking error. The relief valve controller is constructed based on disturbance observer to estimate the unknown disturbance-load force without a force sensor. The servo motor controller is designed via a grey model to predict the displacement of load. From these three sub controllers, the supply pressure and supply flow rate can be derived and controlled to achieve energy saving. Finally, the proposed method was validated by comparative experiments, which shows this control strategy can reduce about half of the power consumption.
An analysis of perceptual cues in robot group selection tasks

The aim of the proposed investigation is to provide the users with the capability of creating robot teams “on- the-fly” using grouping strategies expressed through speech. Our working hypothesis is that people are inclined to assemble objects into macro-entities, or groups, according to perceptual principles. We observed the real linguistic utterances used by individuals in a testing environment, showing that the type of robots and their mutual arrangements can affect both the choice of elements to form a team, and the way such choice is made. Moreover, we provide an initial insight for the capabilities needed by a robot for reasoning about its membership in a team.
1125: CRITICAL CARE OBSERVATION OF MOTOR ACTIVITY: A ROUTINE BEDSIDE EXAM ON SICU OUTCOMES

Crit Care Med 2016 • Volume 44 • Number 12 (Suppl.) cost per case from $39,909.4 to $32,850.3 (p=0.04) after dedicating full-time PT. There was a trend towards decreasing ventilator days, from 8.8d to 6.8d, and decreasing ICU LOS from 4.3d to 3.9d, but did not reach statistical significance. Disposition and readmission rates remained consistent. Conclusions: The expansion of full time PT staff dedicated to early mobilization in the ICU lead to statistically significant decreases in hospital LOS and total cost per admission. Although ventilator and ICU LOS did not reach significance, further expanding the trial period and recruiting a larger patient population would likely yield positive results.
The Ethics of Consumer Involvement with Fashion: A Freedom under Social Pressure

The aim of this work was not only to estimate a model based on the variables of motivation and emotion that underlie the process of interest in new trends, but also to explore the moderating role of socio-demographic characteristics. An empirical work was conducted based on structural equation modeling with a sample of 341 individuals, using path modeling with a multigroup analysis. It was demonstrated that involvement with new fashion is not only a personal more than social need, but also that it is addressed more from an emotional than a cognitive perspective. Moreover, it was demonstrated that involvement with new fashion shows a negative emotional valence when social need is working on the consumer adoption model. In addition, it was shown that there are different ways in which consumers become interested in fashion according to their socio-demographic characteristics. This research lead to recommendations that may serve to improve fashion houses’ plans, by considering the consumer from an ethical perspective. This is a heterodox paper that contradicts the dominant paradigm of the diffusion of fashion since it does not recognize and accept the predominant role of personal influence on social influence but also the antecedent role of emotion on cognition to develop the involvement with new trends.
The War on Illegal Drug Production and Trafficking: An Economic Evaluation of Plan Colombia

This paper provides a thorough economic evaluation of the anti-drug policies implemented in Colombia between 2000 and 2006 under the so-called Plan Colombia. The paper develops a game theory model of the war against illegal drugs in producer countries. We explicitly model illegal drug markets, which allows us to account for the feedback effects between policies and market outcomes that are potentially important when evaluating large scale policy interventions such as Plan Colombia. We use available data for the war on cocaine production and trafficking as well as outcomes from the cocaine markets to calibrate the parameters of the model. Using the results from the calibration we estimate important measures of the costs, effectiveness, and efficiency of the war on drugs in Colombia. Finally we carry out simulations in order to assess the impact of increases in the U.S. budget allocated to Plan Colombia, and find that a three-fold increase in the U.S. budget allocated to the war on drugs in Colombia would decrease the amount of cocaine that succesfully reaches consumer countries by about 17%.
Muscarinic Cholinergic‐Receptor Stimulation of Specific GTP Hydrolysis Related to Adenylate Cyclase Activity in Canine Cardiac Sarcolemma

One component of muscarinic receptor inhibition of the function of cardiac ventricles is mediated by the inhibition of activated adenylate cyclase activity in sarcolemma. We have shown previously that muscarinic agonists inhibit GTP- but not Gpp(NH)p-activated adenylate cyclase activity, and various studies in other tissues indicate that nonhydrolyzable GTP analogues prevent inactivation of the enzyme. These data have suggested a role for GTP hydrolysis in the mechanism of inhibition of adenylate cyclase. The present study demonstrates that purified canine cardiac sarcolemma displays high-affinity GTPase activity that is reciprocally related to adenylate cyclase activity. The high-affinity GTPase activity was stimulated by muscarinic agonists and blocked by atropine. Furthermore, the one-half maximal effects of oxotremorine for binding to muscarinic receptors, stimulation of high-affinity GTPase activity, and inhibition of adenylate cyclase activity were similar. Muscarinic stimulation of GTPase activity and inhibition of adenylate cyclase activity required functional activity of the pertussis toxin (TAP) substrate(s). Treatment of sarcolemmal membranes with IAP attenuated the ability of oxotremorine to both stimulate high-affinity GTPase activity and inhibit adenylate cyclase activity. These studies indicate that muscarinic receptor stimulation of high-affinity GTPase activity dependent on functional IAP substrate(s) is closely linked to the mechanism of muscarinic inhibition of adenylate cyclase activity.
Multi-Sensor Rapid Fire Damage Assessment Over Mediterranean Area

Several studies have clearly demonstrated the capability of suitable algorithms based on satellite images to detect fires scars by using optical and radar data. In the near infrared region (0.7-1.3 micron) green vegetation shows high reflectance values compared to the most other natural surfaces. In general this region of the spectrum contains the most useful information on burned surface detection. After a fire occurs, in fact, a strong reflectance decrease can be found in the burned area. Generally, in a burned surface, the reflectance falls to a low level (5-15 %) because of the presence of ash and carbon over the soil. For this reason the NIR is the more appropriate spectral region for burned areas detection, allowing high contrast between burned and unburned surfaces. Taking the advantage of using the synthetic aperture radar (SAR) for mapping forest volume or above ground biomass in big area, within the burned area, this instrument has been used to detect deep fire scars in order to provide more information on the fire event .
Colloquium: Stimulating uncertainty: Amplifying the quantum vacuum with superconducting circuits

The ability to generate particles from the quantum vacuum is one of the most pro- found consequences of Heisenberg's uncertainty principle. Although the significance of vacuum fluctuations can be seen throughout physics, the experimental realization of vacuum amplification effects has until now been limited to a few cases. Superconducting circuit devices, driven by the goal to achieve a viable quantum computer, may soon be able to realize the elusive verification of the dynamical Casimir effect and analogue Hawking radiation. This article describes several mechanisms for generating photons from the quantum vacuum and emphasizes their connection to the well-known parametric amplifier from quantum optics. Discussed in detail is the possible realization of each mechanism, or its analogue, in superconducting circuit systems. The ability to selectively engineer these circuit devices highlights the relationship between the various amplification mechanisms.
Development of high yield fabrication technology for graphene quantum dots for single electron transistor applications

Since the seminal work by Loss and DiVincenzo, quantum dots (QDs) have been extensively studied as building blocks for quantum information processing (QIP). Presently, the most advanced implementations of QD qubits are realised in III/V heterostructures (GaAs/AlGaAs). However, the strong spin-orbit and hyperfine interactions in these compounds pose fundamental limits to the spin coherence time, and so stimulating the search for alternative host materials. Graphene, a two-dimensional single atomic layer of carbon atoms, was successfully produced for the first time in 2004. Despite its short history, its unique material properties have ensured a rapid growth of interest in several areas of science and technology. Spin-orbit coupling and hyperfine interaction with carbon nuclei are both small in graphene, and a very long spin relaxation length has been demonstrated, which make graphene a promising candidate for quantum information technology and spin qubit embodiment. Superior transport properties of graphene encourage the downscaling of graphene devices to the regime where coherent nature of electronic and spin states can be fully exploited. This requires the development of ultrafine patterning technologies which enables accurate nanoscale fabrication beyond the present electron-beam lithography technique. Therefore, inspired by the on-going trend towards device miniaturization, we present a novel hybrid fabrication method for graphene nano devices (e.g. graphene QDs devices) with minimum feature sizes of ~3 nm (i.e. the gap between the graphene side-gates and channel). Here, for the first time we combine conventional e-beam lithography and direct milling with the sub-nm focused helium ion beam generated by a helium ion microscope to fabricate high resolution graphene QDs devices, reliably and reproducibly. The highly controllable, fine scale fabrication capabilities offered by this approach could lead to a more detailed understanding of the electrical characteristics of graphene quantum devices and pave the way towards room-temperature operable grapheme quantum dot devices.
Aurelia aurita (Cnidaria) Oocytes' Contact Plate Structure and Development

One of the A. aurita medusa main mesoglea polypeptides, mesoglein, has been described previously. Mesoglein belongs to ZP-domain protein family and therefore we focused on A.aurita oogenesis. Antibodies against mesoglein (AB RA47) stain the plate in the place where germinal epithelium contacts oocyte on the paraffin sections. According to its position, we named the structure found the “contact plate”. Our main instrument was AB against mesoglein. ZP-domain occupies about half of the whole amino acid sequence of the mesoglein. Immunoblot after SDS-PAGE and AU-PAGE reveals two charged and high Mr bands among the female gonad germinal epithelium polypeptides. One of the gonads' polypeptides Mr corresponds to that of mesogleal cells, the other ones' Mr is higher. The morphological description of contact plate formation is the subject of the current work. Two types of AB RA47 positive granules were observed during progressive oogenesis stages. Granules form the contact plate in mature oocyte. Contact plate of A.aurita oocyte marks its animal pole and resembles Zona Pellucida by the following features: (1) it attracts spermatozoids; (2) the material of the contact plate is synthesized by oocyte and stored in granules; (3) these granules and the contact plate itself contain ZP domain protein(s); (4) contact plate is an extracellular structure made up of fiber bundles similar to those of conventional Zona Pellucida.
Fabrication and evaluation of an "electrodeless" solidly mounted thin film electroacoustic resonator

A solidly mounted resonator (SMR) that has a bottom electrode with a thickness of one quarter of the acoustic wavelength at resonance has been fabricated. In this configuration, the bottom electrode is uncoupled from the resonance cavity of the SMR rendering it "electrodeless". The uncoupling of the bottom electrode is confirmed both by simulation with the one-dimensional Nowotny-Benes model, and experimentally by comparison with a SMR with a standard thin bottom electrode. The "electrodeless" SMR exhibits reduced series resistance Rs and improved device Q. A solidly mounted resonator (SMR) consists of a piezoelectric thin film, sandwiched between two thin electrodes and is fabricated directly onto a carrier substrate. The resonance frequency of the resonator is determined by the total acoustic thickness of the resonance cavity defined by the piezo- layer and the electrodes. To acoustically isolate the resonator from the substrate, it is fabricated on top of a classical acoustic mirror, here called Bragg reflector. The Bragg reflector consists of a sequence of a quarter wavelength layers of low and high acoustic impedance, respectively (1). In this work the bottom electrode is eliminated from the acoustic cavity of the SMR by incorporating it into the Bragg reflector instead. Choosing a low impedance conducting material as the topmost layer in the reflector, eliminates completely the need for a bottom electrode and brings, in return, a number of significant benefits. Most notably, the ohmic resistance of the resonator is reduced, since the reflector layer is much thicker than the original electrode. Alternatively, the whole stack could be made of conducting materials to reduce ohmic resistance even further. The excitation efficiency is also increased since the bottom electrode, which is piezoelectrically inactive, is no longer part of the resonance cavity. Furthermore, if the acoustic reflector layers are made up entirely of metals, an efficient heat path through the mirror is established, which reduces thermal resistance and should improve the power handling capabilities of the device. By the same token, the top electrode can also be eliminated from the resonance cavity, achieving total acoustic isolation of the resonator from its surrounding in addition to doubling the gains described above. In the present study, a one-port SMR, based on reactively sputtered, c-axis oriented aluminum nitride (AlN) was fabricated according to the schematic in Fig.1. The SMR was fabricated such that the bottom electrode is incorporated into the Bragg reflector. Aluminum was used for the top electrode. The acoustic mirror, underneath the resonators were made of a quarter wavelength aluminum (Al) and molybdenum (Mo) layers, providing electrical contact underneath the piezo-layer. The devices were electroacoustically characterized and the results compared with a thin electrode SMR.
Improved object classification of laserscanner measurements at intersections using precise high level maps

This paper deals with real-time object classification at intersection scenarios. Objects are observed using a multilayer laserscanner. The classification is performed using well-known methods of statistical learning. The statistical classification is corrected by rule based a priori knowledge. Precise high level maps provide the possibility to additionally improve the classification by using infrastructure information and the position of the objects in the scene. Classification results of several neural networks and support vector machines are described. Finally, the improvement by high level maps and the final system performance are presented.
Model Driven Web Engineering: A Systematic Mapping Study

Background: Model Driven Web Engineering (MDWE) is the application of the model driven paradigm to the domain of web software development, where it is particularly helpful because of the continuous evolution of Web technologies and platforms. Objective: In this paper, we prepare a survey of primary studies on MDWE to explore current work and identify needs for future research. Method: Systematic mapping study uses for ﬁnding the most relevant studies and classiﬁcation. In this study, we found 289 papers and a classiﬁcation scheme divided them depending on their research focus, contribution type and research type. Results: The papers of solution proposal (20%) research type are majority. The most focused areas of MDWE appear to be: Web Applicability (31%), Molding and Notation (19%), and Services and Oriented (18%). The majority of contributions are methods (33%). Moreover, this shows MDWE as a wide, new, and active area to publications. Conclusions: Whilst additional analysis is warranted within the MDWE scope, in literature, composition mechanisms have been thoroughly discoursed. Furthermore, we have witnessed that the recurrent recommendation for Validation Research, Solution Proposal and Philosophical Papers has been done through earlier analysis.