Miracle-dz/UniFAR-FTUs huggingface dataset:
Active parents, active children: The importance of parental organized physical activity in children’s extracurricular sport participation

This study investigated whether parental participation in organized and unorganized physical activity (PA) was associated with children’s participation in extracurricular sport. The sample comprised 834 parents and their children (aged 6–10 years), living in central Portugal. Questionnaires assessed parental PA (organized and unorganized) and extracurricular sport participation in children (number of sports and frequency of participation). Multinomial logistic regression was applied to assess associations between parental and child physical behaviors. Having both parents active was significantly associated with frequent participation in more sports both in girls and boys but a strong relation according to gender was found. The odds of boys practicing more than one sport and more times per week were higher if they had an active father. Girls with physically active mothers, particularly with mothers practicing organized PA in a regular way, were engaged in more sports and practiced sport more times per week. The type of PA practiced by the parents was not related to boys’ participation in sport. Future interventions should be family-based and focus on the promotion of higher levels of parental PA, including organized, in order to improve their children’s active behaviors.
Emergence and Stability of High-Pressure Resistance in Different Food-Borne Pathogens

ABSTRACT High hydrostatic pressure (HHP) processing is becoming a valuable nonthermal food pasteurization technique, although there is reasonable concern that bacterial HHP resistance could compromise the safety and stability of HHP-processed foods. While the degree of natural HHP resistance has already been shown to vary greatly among and within bacterial species, a still unresolved question remains as to what extent different food-borne pathogens can actually develop HHP resistance. In this study, we therefore examined and compared the intrinsic potentials for HHP resistance development among strains of Escherichia coli, Shigella flexneri, Salmonella enterica serovars Typhimurium and Enteritidis, Yersinia enterocolitica, Aeromonas hydrophila, Pseudomonas aeruginosa, and Listeria innocua using a selective enrichment approach. Interestingly, of all strains examined, the acquisition of extreme HHP resistance could be detected in only some of the E. coli strains, indicating that a specific genetic predisposition might be required for resistance development. Furthermore, once acquired, HHP resistance proved to be a very stable trait that was maintained for >80 generations in the absence of HHP exposure. Finally, at the mechanistic level, HHP resistance was not necessarily linked to derepression of the heat shock genes and was not related to the phenomenon of persistence.
Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling

We and others have recently shown cisplatin resistance-related protein 9 (CRR9)/Cleft Lip and Palate Transmembrane 1-Like (CLPTM1L) to affect survival and proliferation in lung and pancreatic tumor cells. Our research has indicated that CLPTM1L affects multiple survival signaling pathways in tumor cells under oncogenic, genotoxic, and microenvironmental stress. We have confirmed the association of CLPTM1L with pancreatic cancer by demonstrating overexpression of CLPTM1L in pancreatic tumors and poor survival in patients with high tumor expression of CLPTM1L. Predicting a transmembrane structure, we determined that CLPTM1L could be targeted at the plasma membrane. Herein, we describe the development of mAbs targeting CLPTM1L. Lead antibodies inhibited surface accumulation of CLPTM1L, Akt phosphorylation, anchorage-independent growth, and chemotherapeutic resistance in lung and pancreatic tumor cells. Gemcitabine promoted a physical interaction between CLPTM1L and p110α in pancreatic tumor cells, which was inhibited by anti-CLPTM1L. In vivo treatment with anti-CLPTM1L robustly inhibited the growth of both lung and pancreatic adenocarcinoma xenografts. The efficacy of anti-CLPTM1L correlated with specific epitopes representing important targets in human cancers, particularly those driven by KRas, for which effective targeted therapies have been elusive. This study is the first to report cell-surface exposure of the tumor survival protein CLPTM1L and inhibition of the function of surface CLPTM1L with novel, systematically developed inhibitory mAbs establishing proof of concept of clinically practical agents inhibiting this compelling new tumor survival target in cancer. Mol Cancer Ther; 15(5); 985–97. ©2016 AACR.
Time-of-flight sensor depth enhancement for automotive exhaust gas

The Time-of-Flight (ToF) sensor has been envisioned as a candidate of next generation sensors for intelligent vehicles. One of the problems in automotive environment is that the sensor outputs wrong values if exhaust gas exists in the scene. In this paper, we provide two new contributions to the signal processing aspects of the ToF sensor for automotive use. First, we present the sensor characteristics and models for exhaust gas to cope with them. Second, we develop a depth enhancement algorithm to reject the influence of exhaust gas from multiple images. Experimental results demonstrate the effectiveness of the depth enhancement algorithm for both static data (including ground truth) and on-vehicle data acquired by the sensor mounted on a car.
Why do software packages conflict?

Determining whether two or more packages cannot be installed together is an important issue in the quality assurance process of package-based distributions. Unfortunately, the sheer number of different configurations to test makes this task particularly challenging, and hundreds of such incompatibilities go undetected by the normal testing and distribution process until they are later reported by a user as bugs that we call “conflict defects”. We performed an extensive case study of conflict defects extracted from the bug tracking systems of Debian and Red Hat. According to our results, conflict defects can be grouped into five main categories. We show that with more detailed package meta-data, about 30 % of all conflict defects could be prevented relatively easily, while another 30 % could be found by targeted testing of packages that share common resources or characteristics. These results allow us to make precise suggestions on how to prevent and detect conflict defects in the future.
A new indoor localization system based on Bayesian graphical model

Indoor localization techniques that use wireless local area network beacon signals have recently gained considerable attention among research communities. System accuracy is one of the most important issues in indoor localization technology. We propose a Bayesian graphical model based on fingerprinting location algorithm in this study. The proposed Bayesian model was simulated using OpenBUGS, a graphical user interface. We conducted an experiment to collect a sample of reference points in a testbed with a dimension of 51 × 22 m2. Results show that the proposed model has improved the accuracy by 25.65% using 15 reference points compared with Madigan model.
Direction independent U-function based sensorless control of BLDC motor

In this paper a new function for the sensorless control of brushless DC motor has been introduced. It has the good control characteristics as compared with the real solid state hall sensors. The direction independent U-function is obtained by the direction normalized ratio of square root of squared sum of line to line BEMF to one of the line to line back EMFs. The shape of this signal is like U-letter of alphabet. The simulation studies have been carried out with different speed and load torque references. This function provides the exact replication of the actual solid state Hall sensor positions and provides excellent control over all four quadrants. The proposed method has excellent sustainability in the vibration and load disturbance togetherwith the step load changes. The method is more sensitive at starting and reversals and is stable as real hall signals at other instants.
In search of Poetic Rhythm: Poetry retrieval through text and metre

In this paper a search service developed for the exploitation of a TEI-based Spanish poetry corpus is presented. Besides a textual retrieval, the search service takes advantage of the metrical annotation to retrieve verses and poems with specific rhythms. The Spanish Golden-Age corpus compiles 5078 sonnets written during the 16th and 17th centuries. All the verses have been annotated with metrical information following a semi-automatic process. The paper describes how this type of annotation can be exploited, by means of the search service, to study and understand Spanish Literature, and specifically on the metrical and textual aspects of Spanish Golden-Age Sonnets. The advanced search supports queries whose search terms can be a combination of metrical pattern, sonnet structure, poem title, author name or verse text. An evaluation of the search service, based on user experience analysis, shows that the tool is useful and helpful.
Novel Pt and Pd Based Core-Shell Catalysts with Critical New Issues of Heat Treatment, Stability and Durability for Proton Exchange Membrane Fuel Cells and Direct Methanol Fuel Cells

© 2012 Nguyen Viet Long et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Novel Pt and Pd Based Core-Shell Catalysts with Critical New Issues of Heat Treatment, Stability and Durability for Proton Exchange Membrane Fuel Cells and Direct Methanol Fuel Cells
TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients

The potency of human papillomavirus type 16 (HPV16)-encoded synthetic long peptides (SLP), conjugated to an optimized Toll-like receptor 2 ligand (TLR2-L), was assessed in ex vivo activation of HPV16+ cancer patient-derived T cells. Two highly immunogenic SLP sequences derived from the oncogenic E6 protein of HPV16 were selected and conjugated to a Pam3CSK4-based TLR2-L under GMP conditions. Both conjugates were able to mature human DCs in vitro and to activate human skin-derived antigen-presenting cells (APCs) upon intradermal injection in an ex vivo skin model, associated with induction of a favorable chemokine profile to attract and activate T cells. The conjugated SLPs were efficiently processed by APCs, since HPV16-specific CD4+ and CD8+ T-cell clones isolated from HPV16+ cervical tumors proliferated in response to both conjugates. The TLR2-L SLP conjugates significantly enhanced ex vivo T helper type 1 T-cell activation in cell suspensions obtained from tumor-draining lymph nodes (LN) resected during hysterectomy of HPV16+ cervical cancer patients. These results show that TLR2-L SLP conjugates can activate circulating or LN-derived tumor-specific T cells, a promising outcome for studying these two conjugates in a phase I/II clinical safety and immunogenicity trial.
The 2‐path network problem

Given a graph with nonnegative edge weights and a set D of node pairs, the 2‐path network problem requires a minimum weight set of edges such that the induced subgraph contains a path with one or two edges connecting each pair in D. The problem is NP‐hard. We present two integer programming models for the problem and study properties of associated polytopes, including cutting planes. Two approximation algorithms are suggested and analyzed. Some computational experience is reported. © 2004 Wiley Periodicals, Inc.
Reduced contact resistance between an individual single-walled carbon nanotube and a metal electrode by a local point annealing

The achievement of low-resistance contact is a key requirement for carbon-electrode electronics. In this study, we have obtained contacts with very low resistance between an individual single-walled carbon nanotube (SWNT) and palladium (Pd) electrodes using electric-current-induced Joule heating without destroying the field effect transistor device that these form. The SWNT is deposited onto Pd electrodes prepatterned on a SiO2/Si substrate, through which an electrical pulse is applied for a microsecond duration. As a result, the source–drain current through the SWNT is greatly increased owing to the elimination of tunnelling barriers between the SWNT and the electrodes. In the case of semiconducting SWNTs, the Schottky barrier is estimated to increase slightly after pulse annealing in some cases, resulting in a relatively high resistance and asymmetrical current–voltage characteristics.
Reciprocal Hosts' Responses to Powdery Mildew Isolates Originating from Domesticated Wheats and Their Wild Progenitor

The biotroph wheat powdery mildew, Blumeria graminis (DC.) E.O. Speer, f. sp. tritici Em. Marchal (Bgt), has undergone long and dynamic co-evolution with its hosts. In the last 10,000 years, processes involved in plant evolution under domestication, altered host-population structure. Recently both virulence and genomic profiling separated Bgt into two groups based on their origin from domestic host and from wild emmer wheat. While most studies focused on the Bgt pathogen, there is significant knowledge gaps in the role of wheat host diversity in this specification. This study aimed to fill this gap by exploring qualitatively and also quantitatively the disease response of diverse host panel to powdery mildew [105 domesticated wheat genotypes (Triticum turgidum ssp. dicoccum, T. turgidum ssp. durum, and T. aestivum) and 241 accessions of its direct progenitor, wild emmer wheat (T. turgidum ssp. dicoccoides)]. A set of eight Bgt isolates, originally collected from domesticated and wild wheat was used for screening this wheat collection. The isolates from domesticated wheat elicited susceptible to moderate plant responses on domesticated wheat lines and high resistance on wild genotypes (51.7% of the tested lines were resistant). Isolates from wild emmer elicited reciprocal disease responses: high resistance of domesticated germplasm and high susceptibility of the wild material (their original host). Analysis of variance of the quantitative phenotypic responses showed a significant Isolates × Host species interaction [P(F) < 0.0001] and further supported these findings. Furthermore, analysis of the range of disease severity values showed that when the group of host genotypes was inoculated with Bgt isolate from the reciprocal host, coefficient of variation was significantly higher than when inoculated with its own isolates. This trend was attributed to the role of major resistance genes in the latter scenario (high proportion of complete resistance). By testing the association between disease severity and geographical distance from the source of inoculum, we have found higher susceptibility in wild emmer close to the source. Both qualitative and quantitative assays showed a reciprocal resistance pattern in the wheat host and are well aligned with the recent findings of significant differentiation into wild-emmer and domesticated-wheat populations in the pathogen.
Loss of VHL and Hypoxia Provokes PAX2 Up-Regulation in Clear Cell Renal Cell Carcinoma

Purpose: The paired box gene 2, PAX2, encodes for a transcription factor that is up-regulated during nephrogenesis and becomes silenced in mature epithelium of the glomeruli, the proximal, and distal tubules. Reactivation of PAX2 has been frequently observed in clear cell renal cell carcinoma (ccRCC), a tumor type characterized by loss of von Hippel-Lindau (VHL) tumor suppressor function. The regulation of PAX2 expression in ccRCC is unknown. Experimental Design: We applied reporter gene assays to investigate PAX2 promoter regulation. Furthermore, PAX2 expression was determined in ccRCC cell lines under normoxic and hypoxic condition in a VHL wild-type and mutated background. PAX2 expression was also assessed in 831 human ccRCC and correlated with hypoxia-inducible factor α (HIFα) and clinical parameters. Results: Here, we show that both loss of VHL protein (pVHL) function and hypoxia leads to strong PAX2 reexpression. Using luciferase reporter gene assays, no induction was obtained in spite of six hypoxia response element motifs identified in the promoter of PAX2. Comprehensive immunohistochemical analyses showed significant correlations between PAX2, HIF1α, and HIF2α—target CCND1 expression patterns in ccRCC patients. Notably, PAX2 expression was highly associated with early-stage, well-differentiated ccRCC and, consequently, better clinical outcome (P < 0.0001 each). Additional analyses indicated that PAX2 repressor WT1 and cancer-linked hypomethylation are not important for transcriptional regulation of PAX2 in ccRCC. Conclusion: We conclude that in ccRCC, PAX2 reactivation is driven by HIF-dependent mechanisms following pVHL loss.
LIdioms: A Multilingual Linked Idioms Data Set

In this paper, we describe the LIDIOMS data set, a multilingual RDF representation of idioms currently containing five languages: English, German, Italian, Portuguese, and Russian. The data set is intended to support natural language processing applications by providing links between idioms across languages. The underlying data was crawled and integrated from various sources. To ensure the quality of the crawled data, all idioms were evaluated by at least two native speakers. Herein, we present the model devised for structuring the data. We also provide the details of linking LIDIOMS to well-known multilingual data sets such as BabelNet. The resulting data set complies with best practices according to Linguistic Linked Open Data Community.
High expression of miR-181c as a predictive marker of recurrence in stage II colorectal cancer

INTRODUCTION A standard treatment for stage II colorectal cancer (CRC) is surgical resection without adjuvant chemotherapy. However, the recurrence rate of these patients is approximately 20%. To date, there are no robust biomarkers suitable for predicting recurrence in stage II CRC patients. In this study, microRNAs (miRNAs) extracted from CRC tissues were examined for a possible biomarker to predict recurrence in stage II CRC patients. RESULTS From the comprehensive analysis, 15 miRNAs were selected as candidates for further study. Regarding let-7a, -7d, -7e, miR-23c, -26b, -128a, -151-5p, and -181c, recurrence rates in training cohort patients with higher expression of these miRNAs isolated from their frozen tissues samples were significantly higher than those with lower expression (P < 0.05). According to multivariate analysis, the higher expression of miR-181c was detected as an independent predictive factor of recurrence (P = 0.001, OR: 9.43, 95% CI: 2.57–34.48). Results were similar in miR-181c extracted from FFPE tissues obtained from the training cohort (P = 0.003, OR: 7.46, 95% CI: 1.97–28.57). In the validation cohort using FFPE tissues, the recurrence rate in patients with higher miR-181c expression was significantly higher than those with lower miR-181c expression (P < 0.001). MATERIAL AND METHODS Comprehensive analysis using a highly sensitive miRNA chip was initially performed to select candidate miRNAs associated with recurrence. Candidate miRNAs were analyzed by real-time RT-PCR using RNA from frozen and formalin-fixed, paraffin-embedded (FFPE) tissues. CONCLUSIONS Higher expression of miR-181c may be a useful recurrence predictor of stage II CRC patients.
Topoisomerase IIα-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin

Coadministration of the iron chelator dexrazoxane reduces by 80% the incidence of heart failure in cancer patients treated with anthracyclines. The clinical application of dexrazoxane is limited, however, because its ability to inhibit topoisomerase IIα (TOP2A) is feared to adversely affect anthracycline chemotherapy, which involves TOP2A-mediated generation of DNA double-strand breaks (DSB). Here, we investigated the apoptotic effects of dexrazoxane and the anthracycline doxorubicin, alone and in combination, in a tumor cell line with conditionally regulated expression of TOP2A. Each drug caused apoptosis that was only partly dependent on TOP2A. Unexpectedly, dexrazoxane was found to cause TOP2A depletion, thereby reducing the doxorubicin-induced accumulation of DSB. Despite this latter effect, dexrazoxane showed no adverse effect on doxorubicin-induced apoptosis. This could be explained by the TOP2A-independent apoptotic effects of each drug: those of doxorubicin included TOP2A-independent DSB formation and depletion of intracellular glutathione, whereas those of dexrazoxane were caspase independent. In conclusion, both doxorubicin and dexrazoxane induce apoptosis via TOP2A-dependent and TOP2A-independent mechanisms, the latter compensating for the reduction in cell killing due to dexrazoxane-induced TOP2A depletion. These observations suggest an explanation for the absence of adverse dexrazoxane effects on clinical responses to doxorubicin. [Mol Cancer Ther 2009;8(5):1075–85]
Video Rate Adaptation and Traffic Engineering in Mobile Edge Computing and Caching-Enabled Wireless Networks

Recent advances in software-defined mobile networks (SDMNs), in-network caching, and mobile edge computing (MEC) can have great effects on video services in next generation mobile networks. In this paper, we jointly consider SDMNs, in- network caching, and MEC to enhance the video service in next generation mobile networks. With the objective of maximizing the mean measurement of video quality, an optimization problem is formulated. Due to the coupling of video data rate, computing resource, and traffic engineering (bandwidth provisioning and paths selection), the problem becomes intractable in practice. Thus, we utilize dual-decomposition method to decouple those three sets of variables. Extensive simulations are conducted with different system configurations to show the effectiveness of the proposed scheme.
Numerical Homogenisation of Particle-Reinforced Neo-Hookean Composite

16 three-dimensional representative volume element (RVE) models have been generated to represent incompressible particle-reinforced neo-Hookean composites (IPRNC) with different volume fractions of reinforcements (5%, 10%, 20% and 30%). 27 equal-sized sphere particles were randomly distributed in the RVE and periodic boundary conditions (PBC) have been implemented. Four types of finite deformation (uniaxial tension/compression, simple shear and general biaxial deformation) were studied by means of finit e element (FE) simulations. Results show that a simple incompressible neo-Hookean model can be used to predict the mechanical responses of the IPRNC, and the effective shear modulus of the IPRNC obtained from the FE simulations agrees well with the classical linear elastic estimation.