Miracle-dz/UniFAR-FTUs huggingface dataset:
Bayesian analysis of signaling networks governing embryonic stem cell fate decisions

MOTIVATION Signaling events that direct mouse embryonic stem (ES) cell self-renewal and differentiation are complex and accordingly difficult to understand in an integrated manner. We address this problem by adapting a Bayesian network learning algorithm to model proteomic signaling data for ES cell fate responses to external cues. Using this model we were able to characterize the signaling pathway influences as quantitative, logic-circuit type interactions. Our experimental dataset includes measurements for 28 signaling protein phosphorylation states across 16 different factorial combinations of cytokine and matrix stimuli as reported previously. RESULTS The Bayesian network modeling approach allows us to uncover previously reported signaling activities related to mouse ES cell self-renewal, such as the roles of LIF and STAT3 in maintaining undifferentiated ES cell populations. Furthermore, the network predicts novel influences such as between ERK phosphorylation and differentiation, or RAF phosphorylation and differentiated cell proliferation. Visualization of the influences detected by the Bayesian network provides intuition about the underlying physiology of the signaling pathways. We demonstrate that the Bayesian networks can capture the linear, nonlinear and multistate logic interactions that connect extracellular cues, intracellular signals and consequent cell functional responses.
Influence of Diaphragm Cracks on Load Transversal Distribution Coefficients of PC Multi Girder Bridge

Based on nonlinear theory of reinforced concrete, the influence of diaphragms¡¯ cracking on the load transverse distribution for the prestressed concrete multi-T-girder bridge is studied. Compared with results from traditional theory called hardening connective plates, the applicable range of the theory is determined. From shell element degraded from continuous body, steel and concrete are modeled by layered shell element. With some available criteria, the material nonlinear properties of concrete and steel are considered. Then the procession of cracking, yielding and failure of prestressed concrete multi-T-girder bridge is imitated and the analytical three-dimensional procedure is compiled. For a certain prestressed concrete multi-T-girder bridge, combined with traditional theory of hardening connective plates, some load cases including uniform loads, symmetric loads and offset loads are calculated. From the results, it is shown that the cracks in the diaphragm weaken the transverse connections between the beams, which leads to the unsatisfying change of the transverse distribution of the loads. When the bridge is subjected to uniform loads, the result from the nonlinear procedure is coordinative with that from the theory of hardening connective plates. When the bridge is subjected to symmetric loads and offset loads, the result from the nonlinear procedure is not in agreement with that from the traditional theory and when the diaphragms are in cracks, analysis by the theory of hardening connective plates may lead to large error, which will produce unsafe results.
Recent molecular approaches to understanding astrocyte function in vivo

Astrocytes are a predominant glial cell type in the nervous systems, and are becoming recognized as important mediators of normal brain function as well as neurodevelopmental, neurological, and neurodegenerative brain diseases. Although numerous potential mechanisms have been proposed to explain the role of astrocytes in the normal and diseased brain, research into the physiological relevance of these mechanisms in vivo is just beginning. In this review, we will summarize recent developments in innovative and powerful molecular approaches, including knockout mouse models, transgenic mouse models, and astrocyte-targeted gene transfer/expression, which have led to advances in understanding astrocyte biology in vivo that were heretofore inaccessible to experimentation. We will examine the recently improved understanding of the roles of astrocytes – with an emphasis on astrocyte signaling – in the context of both the healthy and diseased brain, discuss areas where the role of astrocytes remains debated, and suggest new research directions.
An open schema for XML data in Hive

Big data in XML format poses a challenge to distributed data systems. This paper proposes an open Hive schema approach to XML data placement in Hadoop. Placing XML data in Hive with this generic schema to build column-oriented and OLAP-focused XML data warehouse of heterogeneous content has benefits for data access, maintenance and scalability.
Multi-resolution auditory scene analysis: robust speech recognition using pattern-matching from a noisy signal

Abstract Unlike automatic speech recognition systems, humans canunderstand speech when other competing sounds are presentAlthough the theory of auditory scene analysis (ASA)may helpto explain this ability, some perceptual experiments show fu-sion of the speech signal under circumstances in which ASAprinciples might be expected to cause segregation. We pro-pose a model of multi-resolution ASA that uses both high- andlow- resolution representations of the auditory signal in paral-lel in order to resolve this conﬂict. The use of parallel repre-sentationsreduces variabilityforpattern-matching whileretain-ing the ability to identify and segregate low-level features ofthe signal. An important feature of the model is the assump-tion that features of the auditory signal are fused together un-less there is good reason to segregate them. Speech is recog-nised by matching the low-resolution representation to previ-ously learned speech templates without prior segregation of thesignal into separate perceptual streams; this contrasts with theappr oach gener a l l y used by comput at i onal m odels of A S A . Wedescribe an implementation of the multi-resolution model, us-ing hidden Markov models, that illustrates the feasibility ofthis approach and achieves much higher identiﬁcation perfor-mance than standard techniques used for computer recognitionof speech mixed with other sounds.
Lupus Myocarditis Presenting as Acute Congestive Heart Failure: A Case Report

A young woman who had a delivery history 3 months previously presented with dyspnea and orthopnea. Initial findings of physical examination, chest radiography, and echocardiogram showed typical congestive heart failure with severe left ventricular (LV) dysfunction. At first, we considered peripartum cardiomyopathy because she had given birth to a baby 3 months previously. However, even though we massively tried conventional drug therapy for 10 days, the patient still remained with refractory heart failure. We performed additional laboratory studies such as complement level and autoantibodies, of which the results supported systemic lupus erythematosus. We could make the diagnosis of acute lupus myocarditis and treated her with corticosteroid. The symptoms were dramatically disappeared and LV function also improved.
LTE in unlicensed spectrum using licensed-assisted access

It is forecasted that mobile data traffic will increase 1000-fold from 2010 to 2020. As a result, the network must evolve to meet the large and rapidly growing data demand. An effective approach for increasing network capacity is to use additional spectrum. In Rel-13, LTE deployment in unlicensed spectrum is being considered. This feature is called Licensed-Assisted Access (LAA) using LTE. Unlicensed band is attractive due to the large amount of available spectrum. In this paper, we provide an overview of LAA including standardization progress and potential changes. A fairness mechanism for LAA coexistence is also presented. Downlink system performance is analyzed for multi-operator LAA deployment. Three representative scenarios are considered - indoor hotspot, indoor office, and outdoor small cell. It is shown that LAA can offer significant additional capacity to the network. Analysis shows that a co-existence mechanism such as listen-before-talk is needed in co-channel multi-operator deployment to ensure that all users can receive service. With listen-before-talk, co-existence is not an issue even in dense deployment.
Intelligent Reconfigurable Method of Cloud Computing Resources for Multimedia Data Delivery

While users increasingly use such large multimedia data, more people use the cloud computing technology. It is necessary to manage large data in an efficient way, and to consider transmission efficiency for multimedia data of different quality. To this end, an important thing is to ensure efficient distribution of important resources (CPU, network and storage) which constitute cloud computing, and variable distribution algorithms are required therefor. This study proposes a method of designing a scheme for applying MapReduce of the FP-Growth algorithm which is one of data mining methods based on the Hadoop platform at the stage of IaaS (Infrastructure As a Service) including CPU, networking and storages. The method is then for allocating resources with the scheme.
Characterization and Protective Property of Brucella abortus cydC and looP Mutants

ABSTRACT Brucella abortus readily multiplies in professional or nonprofessional phagocytes in vitro and is highly virulent in mice. Isogenic mutants of B. abortus biovar 1 strain IVKB9007 lacking the ATP/GDP-binding protein motif A (P-loop) (named looP; designated here the IVKB9007 looP::Tn5 mutant) and the ATP-binding/permease protein (cydC; designated here the IVKB9007 cydC::Tn5 mutant) were identified and characterized by transposon mutagenesis using the mini-Tn5Km2 transposon. Both mutants were found to be virtually incapable of intracellular replication in both murine macrophages (RAW264.7) and the HeLa cell line, and their virulence was significantly impaired in BALB/c mice. Respective complementation of the IVKB9007 looP::Tn5 and IVKB9007 cydC::Tn5 mutants restored their ability to survive in vitro and in vivo to a level comparable with that of the wild type. These findings indicate that the cydC and looP genes play important roles in the virulence of B. abortus. In addition, intraperitoneal immunization of mice with a dose of the live IVKB9007 looP::Tn5 and IVKB9007 cydC::Tn5 mutants provided a high degree of protection against challenge with pathogenic B. abortus strain 544. Both mutants should be evaluated further as a live attenuated vaccine against bovine brucellosis for their ability to stimulate a protective immune response.
PEMANFAATAN BUKU KECIL-KECIL PUNYA KARYA SEBAGAI BAHAN PEMBELAJARAN SASTRA UNTUK PENGEMBANGAN KARAKTER

Abstrak: Pendidikan karakter adalah usaha sadar untuk menanamkan nilai-nilai karakter pada siswa. Karakter positif yang akan ditanamkan, sebagai contoh religiusitas, etika dalam bekerja, disiplin, jujur, adil, dan bertanggung jawab. Secara formal, pendidikan karakter perlu dilakukan sedini mungkin. Nilainilai pendidikan karakter dapat diintegrasikan ke dalam semua mata pelajaran. Untuk sekolah dasar, bisa diintegrasikan ke dalam pembelajaran sastra (termasuk dalam pembelajaran Bahasa Indonesia). Bahan sastra bisa diambil dari cerita dalam KKPK karena ada banyak nilai di dalamnya. Pemanfaatan sastra sebagai bahan ajar memiliki banyak kelebihan, karena sastra memuaskan/menghibur dan berguna, dulce et utile. Terlebih lagi, cerita dalam KKPK ditulis oleh anak, tentunya terbebas dari pornografi. Kata Kunci: tujuan pendidikan, pendidikan karakter, nilai-nilai karakter, pembelajaran sastra, nikmat bermanfaat THE USE BOOK KECIL-KECIL PUNYA KARYA LEARNING AS LITERATURE FOR CHARACTER DEVELOPMENT STUDENT Abstract: Character education is a concious effort to implant character values to the students. The positive character, that would be implanted, for examples the religious, work ethic, discipline, honest, fair, be responsible, etc. Formally, character education need to be carried out as early as possible. The values of character education could be integrated into all subjects. For the elementary school, it could be integrated into learning of literature (Included in Bahasa Indonesia subject). The material of literature could be taken from stories in KKPK because there are many of values inside of it. Take a literature as a material had many of excesses, because literature is gratify/entertain and useful, dulce et utile. More over, the story in KKPK is written by child, and certainly clean from pornographic. Keywords: goal of education, character education, values of character, learning of literature, dulce et utile
Shifts in reported gaze position due to changes in pupil size: ground truth and compensation

Camera-based eye trackers are the mainstay of today's eye movement research and countless practical applications of eye tracking. Recently, a significant impact of changes in pupil size on the accuracy of camera-based eye trackers during fixation has been reported [Wyatt 2010]. We compared the pupil-size effect between a scleral search coil based eye tracker (DNI) and an up-to-date infrared camera-based eye tracker (SR Research Eyelink 1000) by simultaneously recording human eye movements with both techniques. Between pupil-constricted and pupil-relaxed conditions we find a subject-specific shift in reported gaze position exceeding 2 degrees only with the camera based eye tracker, while the scleral search coil system simultaneously reported steady fixation. This confirms that the actual point of fixation did not change during pupil constriction/relaxation, and the resulting shift in measured gaze position is solely an artifact of the camera-based eye tracking system. We demonstrate a method to partially compensate the pupil-based shift using separate calibrations in pupil-constricted and pupil-dilated conditions, with pupil size as an index to dynamically weight the two calibrations.
Oral contraceptives and colorectal cancer risk: a systematic review and meta-analysis.

BACKGROUND Various studies have reported an inverse relation between oral contraceptive (OC) use and the risk of colorectal cancer, but the issue is still open. METHODS In order to quantify the association between OC use and colorectal cancer risk, we performed a systematic review and meta-analysis of studies on this issue. We identified all relevant studies published, in English, as original articles up to December 2008 through a search of the literature using PubMed and EMBASE, and by reviewing the references from the retrieved articles. RESULTS The summary relative risk of colorectal cancer for ever versus never OC use was 0.82 (95% confidence interval, CI, 0.69-0.97) from 11 case-control studies, 0.81 (95% CI, 0.75-0.89) from seven cohort studies, and 0.81 (95% CI, 0.72-0.92) from all studies combined. The results were similar for colon and rectal cancer. No difference was evident according to duration of OC use both for colon and rectal cancer, although there is an indication that the protection is stronger for more recent use (OR = 0.70, 95% CI, 0.53-0.90, on the basis of four studies). CONCLUSION Epidemiological data consistently indicate that OC users have a reduced risk of colorectal cancer, and that the protection is greater for recent use in the absence, however, of a duration-risk relation.
The Principle of Greatest Happiness in Western Economic Thought and its Relation to Buddhist Economics

Western economic thinkers in the 19th century rediscovered the principle of greatest happiness (PGH). However, as Eastern philosophical and religious thinking shows it was part of common knowledge in Buddhism and Hinduism over the past millennia. PGH did not have the same agenda as later on utilitarism of John Stanley Jevons, with the utility maximization principle (UMP) of individuals disconnected from the rest of the society. The UMP was more an outcome of a fusion between moral ethical thinking as a social phenomenon with the Newtonian principles of mechanics based on differential calculus. The huge success of natural sciences in the 19th century during the industrial revolution was too tempting not to imitate its methodologies and concepts in the social sciences as social physics (SP). This kind of approach still has many followers unsurprisingly in the natural science community nowadays. The paper studies these interconnections between these different strands of Western thinking which lead after a century to the neoclassical paradigm in economics which took the UMP as its foundation for economic analysis. Richard Layard, an English labour economist, pointed out among others by empirical research that wellbeing or happiness is not significantly correlated with an ever increasing material wealth. Here might emerge a bridge between Buddhist economics and the recent rediscovery of the PGH in modern Western economics. The paper will close with the suggestion of some first possible corrections necessary for UMP to obtain a PGH consistent with the current challenges to the global society.
Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β (*)

Proteins in the transforming growth factor-β (TGF-β) superfamily exert their effects by forming heteromeric complexes of their type I and type II serine/threonine kinase receptors. The type I and type II receptors form distinct subgroups in the serine/threonine kinase receptor family based on the sequences of the kinase domains and the presence of a highly conserved region called the GS domain (or type I box) located just N-terminal to the kinase domain in the type I receptors. Recent studies have revealed that upon TGF-β binding several serine and threonine residues in the GS domain of TGF-β type I receptor (TβR-I) are phosphorylated by TGF-β type II receptor (TβR-II) and that the phosphorylation of GS domain is essential for TGF-β signaling. Here we investigated the role of cytoplasmic juxtamembrane region located between the transmembrane domain and the GS domain of TβR-I by mutational analyses using mutant mink lung epithelial cells, which lack endogenous TβR-I. Upon transfection, wild-type TβR-I restored the TGF-β signals for growth inhibition and production of plasminogen activator inhibitor-1 (PAI-1) and fibronectin. A deletion mutant, TβR-I/JD1(Δ150-181), which lacks the juxtamembrane region preceding the GS domain, bound TGF-β in concert with TβR-II and transduced a signal leading to production of PAI-1 but not growth inhibition. Recombinant receptors with mutations that change serine 172 to alanine (S172A) or threonine 176 to valine (T176V) were similar to wild-type TβR-I in their abilities to bind TGF-β, formed complexes with TβR-II, and transduced a signal for PAI-1 and fibronectin. Similar to TβR-I/JD1(Δ150-181), however, these missense mutant receptors were impaired to mediate a growth inhibitory signal. These observations indicate that serine 172 and threonine 176 of TβR-I are dispensable for extracellular matrix protein production but essential to the growth inhibition by TGF-β.
On cooperative source transmission with partial rate and power control

The problem of transmitting a Gaussian source over a half-duplex fading relay channel with limited channel state feedback is studied. It is shown that under a short-term power constraint, combining a simple feedback scheme with separate source and channel coding outperforms the best known no-feedback strategies even with only a few bits of feedback information. Partial power control is shown to be instrumental in achieving a very fast decaying average distortion, especially in the regime of high bandwidth ratios. Performance limitation due to the lack of full channel state information at the destination is also investigated, where the degradation in terms of the distortion exponent is shown to be significant. However, even in such restrictive scenarios, using partial feedback still yields distortion exponents superior to any no-feedback schemes.
Optimal Sampling In the Space of Paths: Preliminary Results

While spatial sampling has received much attention in recent years, our understanding of sampling issues in the function space of trajectories remains limited. This paper presents a structured approach to the selection of a finite control set, derived from the infinite function space of possible controls, which is optimal in some useful sense. We show from first principles that the degree to which trajectories overlap spatially is directly related to the relative completeness that can be expected in sequential motion planning. We define relative completeness to mean the probability, taken over the population of all possible worlds, that at least one trajectory searched will not intersect an obstacle. Likewise, trajectories which are more separated from each other perform better in this regard than the alternatives. A suboptimal algorithm is presented which selects a control set from a dense sampling of the continuum of all possible paths. Results show that this algorithm produces control sets which perform significantly better than constant curvature arcs. The resulting control set has been deployed on an autonomous mobile robot operating in complex terrain in order to respond to situations when the robot is surrounded by a dense obstacle field.
Linux Netlink as an IP Services Protocol

This document describes Linux Netlink, which is used in Linux both as an intra-kernel messaging system as well as between kernel and user space. The focus of this document is to describe Netlink's functionality as a protocol between a Forwarding Engine Component (FEC) and a Control Plane Component (CPC), the two components that define an IP service. As a result of this focus, this document ignores other uses of Netlink, including its use as a intra-kernel messaging system, as an inter-process communication scheme (IPC), or as a configuration tool for other non-networking or non-IP network services (such as decnet, etc.).
Teacher perceptions of training and intention to use robotics

This paper presents an overview of a work in progress research project that investigated cycle 2 in-service teachers' perceptions of the effectiveness of a training offered in the United Arab Emirates on how to use and integrate robotics in teaching. The project also investigated teacher beliefs, attitudes and intention to use robotics in their future teaching. A description of the training offered to cycle 2 teachers is presented. Potential contributions to the context and knowledge as well as future work are discussed.
Achieving secure friend discovery in social strength-aware PMSNs

With Proximity-based Mobile Social Networks (PMSNs), mobile users can discover and make new social interactions easily with physical-proximate others through WiFi/Bluetooth interfaces embedded in the smartphones. Unfortunately, users enjoy these conveniences at the cost of revealing their personal data. Furthermore, an important factor called social strength, which impacts the discovering result a lot, is always ignored. To address these problems, we propose S-match, which aims to achieve secure friend discovery in social strength-aware PMSNs. Specifically, S-match exploits a two-dimensional similarity vector with considering both priority-aware similarity coefficient and social strength-aware similarity coefficient. We construct a similarity evaluation model based on entropy method to measure profile similarity, as well as a novel priority-aware similarity coefficient by improving Jaccard similarity function. Finally, the combination of the homomorphic property and the priority-aware similarity coefficient guarantee the avoidance on the insider attacks. The security and performance are thoroughly analyzed and evaluated via detailed simulations.