Miracle-dz/UniFAR-FTUs huggingface dataset:
Nurse Staffing and Patient Safety in Hospitals: New Variable and Longitudinal Approaches

Background:Most studies of the relationship between nurse staffing and patient outcomes in hospitals have shown that worse patient outcomes are associated with lower registered nurse (RN) staffing. However, inconsistent results exist, possibly because of the use of a variety of nurse staffing and patient outcomes measures and because of statistical methods that employ static, instead of change, relationships. Objectives:The aim of the study was to examine the relationship between changes in RN staffing and patient safety events in Florida hospitals from 1996 through 2004. Methods:Using 9 years of data from 124 Florida hospitals, latent growth curve models were used to assess the impact on patient safety of RN staffing changes in hospitals. Patient safety measures were 4 of the 20 provider-level patient safety indicators (PSIs) developed by the Agency for Healthcare Research and Quality. Two measures of RN staffing—RN full-time equivalents and RN per adjusted patient day—were analyzed. Results:Changes in RN full-time equivalents were positively related to changes in RN per adjusted patient day. All PSIs were negatively and significantly related to one or both RN staffing measures. Failure to rescue had the strongest relationship to RN staffing. Models of change relationships between staffing and PSIs were more likely to show significant relationships than models using initial levels. Initial levels of RN staffing tended to be unrelated to initial levels of PSIs. Discussion:A negative relationship between RN staffing and PSIs was strongly supported with failure to rescue and was weakly supported with decubitus ulcers, selected infections, and postoperative sepsis. The PSIs should be retested in an expanded change model study using multistate or national sample Healthcare Cost and Utilization Project data.
Nicotiana attenuata SIPK, WIPK, NPR1, and Fatty Acid-Amino Acid Conjugates Participate in the Induction of Jasmonic Acid Biosynthesis by Affecting Early Enzymatic Steps in the Pathway1[W][OA]

Wounding and herbivore attack elicit the rapid (within minutes) accumulation of jasmonic acid (JA) that results from the activation of previously synthesized biosynthetic enzymes. Recently, several regulatory factors that affect JA production have been identified; however, how these regulators affect JA biosynthesis remains at present unknown. Here we demonstrate that Nicotiana attenuata salicylate-induced protein kinase (SIPK), wound-induced protein kinase (WIPK), nonexpressor of PR-1 (NPR1), and the insect elicitor N-linolenoyl-glucose (18:3-Glu) participate in mechanisms affecting early enzymatic steps of the JA biosynthesis pathway. Plants silenced in the expression of SIPK and NPR1 were affected in the initial accumulation of 13-hydroperoxy-linolenic acid (13-OOH-18:3) after wounding and 18:3-Glu elicitation by mechanisms independent of changes in 13-lipoxygenase activity. Moreover, 18:3-Glu elicited an enhanced and rapid accumulation of 13-OOH-18:3 that depended partially on SIPK and NPR1 but was independent of increased 13-lipoxygenase activity. Together, the results suggested that substrate supply for JA production was altered by 18:3-Glu elicitation and SIPK- and NPR1-mediated mechanisms. Consistent with a regulation at the level of substrate supply, we demonstrated by virus-induced gene silencing that a wound-repressed plastidial glycerolipase (NaGLA1) plays an essential role in the induction of de novo JA biosynthesis. In contrast to SIPK and NPR1, mechanisms mediated by WIPK did not affect the production of 13-OOH-18:3 but were critical to control the conversion of this precursor into 12-oxo-phytodienoic acid. These differences could be partially accounted for by reduced allene oxide synthase activity in WIPK-silenced plants.
Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix

The acrosome is an exocytotic vesicle located on the apical tip of the sperm head. In addition to having different morphological regions, two biochemically distinct compartments can be defined within the acrosome: a particulate acrosomal matrix and a soluble partition. The domains within the acrosome participate in the release of acrosomal proteins from the sperm during exocytosis, depending on whether the proteins partition into either the soluble or matrix compartments of the acrosome. We have examined the mechanism of differential release by evaluating the solubilization of acrosomal matrix protein ZP3R (sp56) from mouse sperm during the course of spontaneous acrosomal exocytosis. Using indirect immunofluorescence and immunoblotting, we found that the ZP3R monomer is processed from 67,000 Mr to 43,000 Mr by proteases coincident with release from the acrosome. Sperm require a maturational step, termed capacitation, before they are competent for acrosomal exocytosis and the processing of ZP3R is dramatically reduced under non-capacitating conditions. The cleavage probably takes place in complement control protein domain (CCP) 6 or the bridge region between CCP6 and CCP7, which is not present in the guinea pig orthologue AM67. The cleaved form of ZP3R does not bind to unfertilized eggs. We have incorporated these structural considerations into a model to explain the functional consequences of acrosomal exocytosis on sperm-zona interactions.
Stabilization of uncertain nonlinear systems via sliding modes

This paper focuses on the stabilization problem of the class of uncertain systems satisfying the condition we named " weakly triangularity". The addressed class includes the systems fui Hing the traditional matching condition, and includes also the strictly triangular uncertainties for which the solution of the stabilization problem is well established in literature. A constructive procedure for system stabilization is proposed, where Variable Structure Control and Feedback Linearization Techniques are combined. Simulation results are reported.
Attention Constraints and Liquidity Provision: An Experimental Study

This paper uses an experimental asset market to investigate the role of attention constraints on the market maker’s ability to provide liquidity and, thus, on the overall liquidity of the market. The market contains salient features of a market making system in an order-driven market, as well as informed and uninformed traders. The experiment consists of a repeated measures design with market-specific (e.g., trading activity and time), asset-specific (e.g., information value), and behavioral explanatory factors (e.g., attention constraints and trading motive). In this way, the paper precludes the use of very noisy measures of attention constraints seen in previous studies. The experimental data will be collected during the last quarter of this current year. The statistical and economic findings will then be available and added to this paper. JEL Classification: D47, G02, G10, G14
Chemotherapeutic drugs that penetrate the blood–brain barrier affect the development of hyperactive delirium in cancer patients

Abstract Objective: Delirium is a frequently encountered psychiatric disease in terminal cancer patients. However, the mechanism of delirium is unclear. The aim of our study was to investigate the relationship between administration of chemotherapy drugs that penetrate the blood–brain barrier (BBB) and the development of delirium in cancer patients. Method: We retrospectively analyzed 166 cancer patients (97 males, 69 females) continuously who died between September of 2007 and January of 2010 using a review of medical charts. Multiple logistic regression analysis was employed to investigate the effects of antineoplastic drugs penetrating the BBB on development of delirium in cancer patients with control for other risk factors. Results: In multivariate analysis, antineoplastic drugs that penetrated the BBB were significantly associated with development of delirium (OR = 18.92, CI 95 = 1.08–333.04, p < 0.001). Significance of results: The use of chemotherapy drugs that penetrate the BBB may be a risk factor for delirium. This information may allow palliative care doctors and medical oncologists to predict which patients are at increased risk for delirium.
A Survey on Frequent Pattern Mining Methods Apriori , Eclat , FP growth

----------------------------------------************************---------------------------------Abstract: Frequent Pattern Mining is very imporatant task in association mining. Data mining is emerging technology which is continuously increasing its importance in all the aspects of human life. As an important task of data mining, Frequent pattern Mining should understood by researchers to make modification in existing algorithms or to utilize algorithm and methods in more specific way to optimize minig process. This paper concentrate on the study of basic algorithm of frequent pattern mining and its working. It also focus on advantage and disadvantage of algorithms. Basic algorithm studied in this paper are (1) Apriori (2) Eclat (3) FP Growth. Mining of association rules from frequent pattern from massive collection of data is of interest for many industries which can provide guidance in decision making processes such as cross marketing, market basket analysis, promotion assortment etc.
Design of sharp-rejection and low-loss wide-band planar filters using signal-interference techniques

A new class of sharp-rejection, low insertion-loss wide-band planar filters is presented in this letter. The proposed filter topology uses transversal signal-interference filtering sections made up of two transmission-line segments connected in parallel. Thus, under signal-interaction principles, the filtering action comes about through the generation of multiple out-of-band power transmission zeros and constructive in-passband signal combinations. Design equations and guidelines to adjust both the bandwidth and the out-of-band performance of the filtering response through the design parameters of the transversal section are also provided. Furthermore, the theoretical results are validated with the manufacture and characterization of an ultra-wideband microstrip filter prototype at 5 GHz.
MMP 41-1 Gene Expression of Grafted Bone in Calvarial Defect in Mice การศึกษาลกัษณะการแสดงออกของยนีของกระดูกปลูกถ่ายในกระโหลกศีรษะของหนู

Bone is a dynamic tissue that coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts, under regulation of many systemic and local factors . The purpose of this study was to evaluate genes of interest indicate osteoblast and osteoclast activity in bone remodeling including Bcl2A1 and S100A4 after bone grafting with demineralized freeze-dried human bone (DFDBA) and deproteinized bovine bone mineral (DBBM), and compare them to natural bone healing using quantitative real-time polymerase chain reaction (qPCR). At 3 month , the DBBM group was shown significantly higher of S100A4 mRNA levels when compared with both control and DFDBA groups (P<0.05). Both 1 and 3 months periods, The control group was shown significantly higher of Bcl2A1 transcription than DBBM group (P<0.05). The results of this study suggest that DFDBA and DBBM could be used for the repair of bone defects. บทคดัย่อ กระดูกเป็นเน้ือเยื อ่ท่ีประสานความสมดุลระหวา่งการสร้างกระดูกโดยเซลลส์ร้างกระดูก และการสลายกระดูก โดยเซลลส์ลายกระดูกภายใต ้การศึกษาคร้ังน้ีมีวตัถุประสงคเ์พ่ือประเมินการแสดงออกของยีนท่ีน่าสนใจบ่งช้ีถึงการ ท างานของเซลลส์ร้างกระดูกและเซลลส์ลายกระดูกในการสร้างกระดูกใหม่ หลงัการปลูกถ่ายกระดูกดว้ยวสัดุปลูกถ่าย เอกพนัธ์ุชนิดผ่านการละลายของแร่ธาตุภายใตส้ภาวะแช่แข็งหรือดีเอฟดีบีเอ และ วสัดุปลูกถ่ายวิวิธพนัธ์ุท่ีไดจ้ากววัท่ี ผ่านการสลายโปรตีนหรือดีบีบีเอ็มเปรียบเทียบกบัการรักษากระดูกธรรมชาติ โดยใชป้ฏิกิริยาลูกโซ่โพลิเมอร์แบบ เรียลไทมเ์ชิงปริมาณ ซ่ึงในเดือนท่ี 3 กลุ่มดีบีบีเอ็ม แสดงระดบัของเอ็มอาร์เอ็นเอของยีนเอสวนัฮลัเดสเอโฟว ์สูงกว่า กลุ่มควบคุมและกลุ่มดีเอฟดีบีเออยา่งมีนยัส าคญัทางสถิติ (P<0.05) และพบวา่แสดงระดบัของเอม็อาร์เอ็นเอของยนีบีซี แอลทูเอวนัทั ้ งในเดือนท่ี 1 และ 3 ของกลุ่มควบคุมมีการแสดงออกสูงกว่ากลุ่มดี-บีบีเอ็มอย่างมีนัยส าคญัทางสถิติ (P<0.05) ผลการศึกษาคร้ังน้ีช้ีให้เห็นว่าดีเอฟดีบีเอและดีบีบีเอ็มสามารถน ามาใช้ในการซ่อมแซมขอ้บกพร่องของ กระดูกได ้
Client RM AM NM NM Container Container Job submission Note status Application status Resource request

With the end of CPU core scaling due to dark silicon limitations, customized accelerators on FPGAs have gained increased attention in modern datacenters due to their lower power, high performance and energy efficiency. Evidenced by Microsoft’s FPGA deployment in its Bing search engine and Intel’s 16.7 billion acquisition of Altera, integrating FPGAs into datacenters is considered one of the most promising approaches to sustain future datacenter growth. However, it is quite challenging for existing big data computing systems—like Apache Spark and Hadoop—to access the performance and energy benefits of FPGA accelerators. In this paper we design and implement Blaze to provide programming and runtime support for enabling easy and efficient deployments of FPGA accelerators in datacenters. In particular, Blaze abstracts FPGA accelerators as a service (FaaS) and provides a set of clean programming APIs for big data processing applications to easily utilize those accelerators. Our Blaze runtime implements an FaaS framework to efficiently share FPGA accelerators among multiple heterogeneous threads on a single node, and extends Hadoop YARN with accelerator-centric scheduling to efficiently share them among multiple computing tasks in the cluster. Experimental results using four representative big data applications demonstrate that Blaze greatly reduces the programming efforts to access FPGA accelerators in systems like Apache Spark and YARN, and improves the system throughput by 1.7× to 3× (and energy efficiency by 1.5× to 2.7×) compared to a conventional CPU-only cluster.
DECISION SUPPORT FOR PRECISION FARMING COMPLEX

Modern methods of thematic cartography and resource management are demanded more and more for remote sensing data (RSD) processing. These data are used in areas such as cartography and land cadastre [1], agronomy and precision agriculture [2,3], a forestry [4], a development of water systems [5], an environmental monitoring [6] etc. One of the most important areas of image processing is a precision agriculture area. Efficient processing of raw data allows reducing material and other costs in problems associated with crop cultivation and forecasting, a monitoring of level of crops germination and many other applications. The basic concept of precision agriculture is the fact that a vegetation cover is not uniform within a single field. Up-to-date technologies are used to evaluate and detect these irregularities: global positioning systems (GPS, GLONASS), special sensors, aerial photographs and satellite imagery, as well as special software systems based on GIS. RSD are used for a more accurate evaluation of the seeding density, calculation of application rates and crop protection, more accurate prediction of yield and financial planning. Also, it must take into account local peculiarities of soil and climatic conditions. In some cases it may make it easier to determine the reasons for the deterioration of vegetation. There are a number of systems for precision agriculture tasks: The Monitoring of Agriculture with Remote Sensing (MARS), Variogram Estimation and Spatial Prediction plus ERror (VESPER), Ag Leader Insight etc. These systems are based on remote sensing processing methods, which allow effective detecting field areas that are infected by plant diseases. Detection and recognition of an infection on early stages of its development reduces costs of plant protective measures.
Chapter 2 Fast Solutions to Real-Data Discrete Fourier Transform

This chapter discusses the two approaches conventionally adopted for dealing with the real-data DFT problem. The first approach involves the design of specialized fast algorithms, such as those due to Bergland and Bruun, which are geared specifically to addressing real-data applications and therefore able to exploit, in a direct way, the real-valued nature of the data – which is known to result in a Hermitian-symmetric frequency spectrum. The second approach, which is the most commonly adopted, particularly for applications requiring a hardware solution, involves re-structuring the data so as to use an existing complex-data FFT algorithm, possibly coupled with pre-FFT and/or post-FFT stages, to produce the DFT of either one or two (produced simultaneously) real-valued data sets – such solutions thus said to be obtained via a “real-from-complex” strategy. A discussion is finally provided relating to the results obtained in the chapter.
Upper Limb Contributions to Frontal Plane Balance Control in Rollator-Assisted Walking

While assisting with balance is a primary reason for rollator use, few studies have examined how the upper limbs are used for balance. This study examines upper limb contributions to balance control during rollator-assisted walking. We hypothesized that there would be an increased upper limb contribution, measured by mean vertical loading (Fz) and variation in frontal plane center-of-pressure (COPhigh), when walking balance is challenged/impaired. Experiment 1 compared straight-line and beam-walking in young adults (n = 11). As hypothesized, Fz and COPhighincreased in beam-walking compared to baseline (mean Fz: 13.7 vs. 9.1% body weight (BW), p < 0.001, RMS COPhigh: 1.35 vs. 1.07 cm, p < 0.001). Experiment 2 compared older adults who regularly use rollators (RU, n = 10) to older adult controls (CTL, n = 10). The predicted higher upper limb contribution in the RU group was not supported. However, when individuals were grouped by balance impairment, those with the lowest Berg Balance scores (< 45) demonstrated greater speed-adjusted COPhigh than those with higher scores (p = 0.013). Furthermore, greater COPhigh and Fz were correlated to greater reduction in step width, supporting the role of upper limb contributions to frontal plane balance. This work will guide studies assessing reliance on rollators by providing a basis for measurement of upper limb balance contributions.
Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow‐up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 3–30%; ptrend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 36–7%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.
Efficacy of recombinant adenovirus expressing a fusion gene from GM-CSF and Epstein-Barr virus LMP2A in a mouse tumor model

ABSTRACT In this study, purified GM-CSF and LMP2A mRNAs were amplified by PCR. Then, the GM-CSF and LMP2A sequences were connected by the polypeptide linker (Gly4Ser)3 using gene splicing by overlap extension. The constructed fusion gene GC2A was inserted into the adenovirus vector. Then the recombinant vector was introduced into HEK 293T cells by calcium phosphate transfection to package the adenovirus. The levels of antibodies against the GM-CSF and LMP2Afusion proteins were measured by ELISA, and the CTL activity of the mouse splenic lymphocytes was determined by lactate dehydrogenase (LDH) release assay. Immunotherapy of mouse tumor (EBV-positive epithelial tumor cell line (GT39)) tissues was performed, and their morphologies were assessed. Finally, the data of each group were analyzed using SPSS 11.5 statistical software. The recombinant adenovirus could replicate in HEK 293Tcells and induce humoral and cellular immune responses in the mice. The maximum dose resulted in an antibody titer of 18500 (184.5 ± 8.7 pg/ml). At an effector: target ratio of 40:1, maximum specific lysis was observed which was approximately three times that detected in the control immunized mice. The tumor inhibition rate was approximately 76% compared with the control groups, indicating the presence of significant differences among the groups. Tumor-infiltrating lymphocytes were detected by hematoxylin-eosin (HE) staining. The recombinant adenovirus induced humoral and cellular immune responses and inhibited tumor growth in mice. It provided a theoretical basis and candidate vaccine for further preclinical trials.
Erythropoiesis following bone marrow transplantation from donors heterozygous for β‐thalassaemia

Summary This study shows a marked and protracted activation of HbF synthesis in homozygous β°‐thalassaemia patients transplanted from HLA identical siblings heterozygous for β‐thalassaemia, as compared to patients transplanted from normal donors. HbF synthesis in recipients was much higher in relation to the corresponding bone marrow donor values either normal or heterozygous for β thalassaemia.
A Comparison of the Top Four Enterprise-Architecture Methodologies

Home Library Learn Samples Downloads Support Community Forums MSDN Library Servers and Enterprise Development Architecture Trends Enterprise Architecture Architecture in Turbulent Times A Better Path to Enterprise Architectures A Comparison of the Top Four Enterprise-Architecture Methodologies A Day in the life of an Enterprise Architect From Capabilities to Services: Moving from a Business Architecture to an IT Implementation Integration of Enterprise Architecture and Application Portfolio Management Maturity Assessment for the Enterprise Architecture Function Microsoft Migration Planning Process, Part 1: "Why Migrate? " Pragmatic Approach to Describing Solution Architectures
COMPARISON OF NANOFILTRATION AND REVERSE OSMOSIS MEMBRANES PERFORMANCE SUBJECT TO CROSSFLOW VELOCITY EFFECT DURING FILTRATION OF HUMIC ACIDS

1 Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia. 2 Department of Civil Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Jalan Genting Kelang, 53300 Setapak, Kuala Lumpur, Malaysia. 3 Department of Civil and Structural Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia. Corresponding author’s email: kooch@utar.edu. my