Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain Inspired Automatic Directory

The fascinating question of the relation of information and coding theory to the memories stored in the brain is our research scope. We speculate there is a similar code used to represent different memories, rather than unique code for different memories. The uniform cortex structure supports our speculation. Recently we suggested holographic coding that can fit Pribram's holographic memory theory. Using the holographic coding metaphor, the memory should be retrieved by a reference beam as in a hologram. We explore the possibility that the brain learns its directory (possibly in the temporal lobe), during memory consolidation. This directory is a neural network that is used for sending signals to the cortex to recall memories. The network learns to distinguish between objects during saving, in order to signal the correct recall. Haar features (HF) are 0/1 matrices used for face recognition. We use HF to learn to differentiate between objects. Namely when objects are saved, our system learns what is the best set of HF to distinguish between them using a genetic algorithm. The sets of HF are tested for the best clustering set without knowing their semantics (unsupervised learning). Later semantics is learned by interaction with the environment. The best sets continue to the next generation. We chose unsupervised learning due to the idea that it is possible to distinguish objects without knowing their identity.
Real-Time , Dynamic Hardware Accelerators for BLAS Computation

This paper presents an approach to increasing the capability of scientific computing through the use of real-time, partially reconfigurable hardware accelerators that implement basic linear algebra subprograms (BLAS). The use of reconfigurable hardware accelerators for computing linear algebra functions has the potential to increase floating point computation while at the same time providing an architecture that minimizes data movement latency and increase power efficiency. While there has been significant work by the computing community to optimize BLAS routines at the software level, optimizing these routines in hardware using reconfigurable fabrics is in its infancy. This paper begins with a comprehensive overview of the history and evolution of BLAS for use in scientific computing. In the reviews current successes in using reconfigurable computing architectures achieve acceleration. It then presents an investigation of an accelerator approach with a granularity at the logic circuit level through real-time, partial reconfiguration of a programmable fabric with static accelerator cache memory to minimize data movement. Empirical data is presented for a study on a single-FPGA. Keywords-Basic linear algebra subprograms; partial reconfiguration; reconfigurable computers __________________________________________________*****_________________________________________________
Overproduction of SecA Suppresses the Export Defect Caused by a Mutation in the Gene Encoding the Escherichia coli Export Chaperone SecB

ABSTRACT SecB is a cytosolic protein required for rapid and efficient export of particular periplasmic and outer membrane proteins inEscherichia coli. SecB promotes export by stabilizing newly synthesized precursor proteins in a nonnative conformation and by targeting the precursors to the inner membrane. Biochemical studies suggest that SecB facilitates precursor targeting by binding to the SecA protein, a component of the membrane-embedded translocation apparatus. To gain more insight into the functional interaction of SecB and SecA, in vivo, mutations in the secA locus that compensate for the export defect caused by the secBmissense mutation secBL75Q were isolated. Two suppressors were isolated, both of which led to the overproduction of wild-type SecA protein. In vivo studies demonstrated that the SecBL75Q mutant protein releases precursor proteins at a lower rate than does wild-type SecB. Increasing the level of SecA protein in the cell was found to reverse this slow-release defect, indicating that overproduction of SecA stimulates the turnover of SecBL75Q-precursor complexes. These findings lend additional support to the proposed pathway for precursor targeting in which SecB promotes targeting to the translocation apparatus by binding to the SecA protein.
Parenting stress in mothers and fathers of a child with a hemiparesis: sources of stress, intervening factors and long-term expressions of stress.

BACKGROUND In a substantial minority of children with a hemiparesis, motor impairments are accompanied by behavioural problems. This combination confronts parents with several persistent, frequently intense, sources of stress. At the same time, it is likely to reduce the effectiveness of psychosocial resources, such as feelings of competence, which would normally buffer the impact of the stressors. Aim To investigate the association between motor and behavioural problems in children with a hemiparesis and symptoms of stress in their parents, with particular attention to psychosocial factors which may mediate between the child's problems and parents' symptoms of stress. METHOD Questionnaires assessing the medical, functional and behaviour problems of the child, and the parents' experience of stress were completed by the mothers and fathers of 108 children with a hemiparesis who were members of the Association for the Motor Handicapped in the Netherlands. RESULTS Both parents reported (extremely) high levels of long-term stress significantly more frequently than parents in a normative sample. Indices of long-term stress were associated with the child's behavioural problems and, less strongly, with dysfunctionality in daily life. However, behavioural problems and dysfunctionality also reduced parents' feelings of competence and social support. A mediation analysis showed that feelings of incompetence and social isolation mediated between the child's problems and the parents' symptoms of stress. Fathers and mothers did not differ in level of reported stress, or in the associations between the child's problems and degree of experienced stress. CONCLUSION Both parents of a child with a hemiparesis experience high levels of stress, which are strongly associated with feelings of incompetence and social isolation. This suggests that one focus of intervention should be the alleviation of parenting stress with particular attention to increasing perceived competence in the parenting role and reducing feelings of social isolation.
IDDT Testing of Embedded CMOS SRAMs

This paper presents an iDDT test method for embedded CMOS SRAMs. A total of 192 faults were inserted and simulated using parameters from a 0.35 um process. The SRAM model includes realistic effects such as wire bonding inductance and resistance parameters as well as bypass capacitance. A sensor is introduced and incorporated into the SRAM cell array to detect abnormal iDDT switching. Figure 1 shows a 1-bit SRAM organized into 64 128 x 128 cell blocks with an iDDT sensor monitoring each cell block. The SRAM model includes the following parameters: ? On-chip wire bonding inductance of 2 nH ? On-chip wire bond resistance of . 01 Ohms ? On-chip bypass capacitance of 1 pF ? Bitline capacitance of 3 pF ? Power line capacitance of 40 pF The results of the fault simulations comparing voltage, IDDQ and iDDT test methods are given in Table 1.
Influence of brine treatment,drying methods and storage conditions on the microbial quality of freshwater snail (Lanistes libycus) meat.

Freshwater snail (Lanistes libycus) meat samples were subjected to four different preservation treatments (ovendried, sun-dried, brined oven-dried, brined sun-dried) and assessed for microbiological quality. The microbial quality of fresh or brine (5 % w/v NaCl) treated samples stored at different temperatures (35, 28, 4, -7 oC) were also investigated. Combining brine treatment with either ovendrying or sun-drying resulted in significant (p = 0.05) decrease in total viable counts (TVCs) of the meat with that of brined oven-dried samples being more pronounced (log10 3.92 cfu g-1) by day 4 of ambient storage. Sun-drying alone could not effectively preserve the meat beyond 2 days. No significant difference (p = 0.05) existed in the microbial loads of oven-dried and brined sun-dried samples stored at ambient temperature. The TVCs of all traditionally dried samples were microbiologically unacceptable (>(log10 5.0 cfu g-1) after 4 days of ambient storage with Bacillus, Clostridium, Staphylococcus sp and Aspergillus flavus being dominant microorganisms isolated. Whereas the fresh meat of L. libycus treated with 5 % w/v NaCl and stored at low temperatures (4, -7 oC) exhibited drastic reduction in microbial load with shelf-life extension to 6 days, that stored at 28 oC preserved the meat for 4 days.
Ocular graft-versus-host disease

Purpose of reviewThis review was carried out to study the frequency, and severity of ocular surface involvement at the setting of allogeneic hematopoietic stem cell transplantation and subsequent graft-versus-host disease (GVHD) and evaluate the clinical outcomes of newer treatments. Recent findingsOcular involvement has been reported in 60–90% of patients with chronic GVHD. Although dry eye is the most frequent finding occurring in the great majority of patients (up to 90%), posterior segment complications are also not infrequent, seen in 12.8% of patients after bone marrow transplantation. Anti-inflammatory treatments particularly T-cell suppressants seem to have a beneficial effect in managing GVHD. Corticoteroids, calcineurin inhibitors, such as cyclosporine and tacrolimus, as well as antifibrotic agents such as tranilast are available options for topical application. Cyclosporine ophthalmic drop seems to be a well tolerated and effective treatment modality; favorable results have been demonstrated with increased dosage. SummaryGVHD is an increasingly frequent cause of ocular surface morbidity with the potential of visual loss from corneal involvement. Early diagnosis and aggressive local as well as systemic treatment can be vision saving.
Membrane properties and synaptic responses of the guinea pig nucleus accumbens neurons in vitro.

1. The membrane properties and synaptic responses of guinea pig nucleus accumbens neurons in vitro were studied with intracellular recording methods. 2. The population of neurons could be divided into groups of low (20-60 M omega, average 46.5 M omega) and high (60-180 M omega, average 96.5 M omega) input resistance. The resting membrane potential in both groups was approximately -70 mV. 3. Other membrane properties were quite similar in both groups. Inward rectification occurred at potentials more negative than -80 mV; this was blocked by Cs+ (2 mM). Membrane potential oscillations were observed at potentials between -65 and -55 mV; these were blocked by tetrodotoxin (TTX, 0.5 microM). Outward rectification occurred at potentials less negative than -45 mV; this was depressed by tetraethylammonium (TEA, 10 mM). 4. Action potentials elicited by small depolarizing current pulses (2-5 ms, 0.3-0.5 nA) were approximately 95 mV in amplitude and 1.0 ms in duration. The afterhyperpolarization following each action potential was less than 30 ms in duration, and no accommodation of action-potential discharge was seen at frequencies up to 40 Hz. The action potentials were reversibly blocked by TTX (0.3 microM). In addition, TTX-insensitive, Ca2+-dependent spikes were evoked by passing larger and more prolonged current pulses (greater than 40 ms, greater than 0.5 nA) across the membrane. 5. Focal electrical stimulation of the slice surface with low intensity (1 ms, less than 10 V) elicited excitatory postsynaptic potentials (EPSPs) in neurons of both high- and low-resistance groups. The reversal potential (+10.2 mV) for the EPSPs was close to the reversal potential (+7.7 mV) of the responses to glutamate applied in the superfusing solution. The N-methyl-D-aspartic acid (NMDA) receptor antagonists, D-alpha-aminoadipic acid (1 mM) and DL-2-amino-5-phosphonovaleric acid (DL-APV, 250 microM), reversibly depressed the EPSP; the glutamate uptake inhibitor, L-aspartic acid-beta-hydroxamate (50 microM), or removal of Mg2+ from the superfusate, augmented the EPSP. 6. When the intensity of the focal stimulus was increased (1 ms, greater than or equal to 10 V), a second larger depolarizing response (duration, 800 ms to 2 s) could be evoked in addition to the smoothly graded EPSP. This was seen only in cells of the high-resistance group (90-130 M omega). (ABSTRACT TRUNCATED AT 400 WORDS)
Design and Implementation of an Algorithm for Finding Frequent Sequential Traversal Patterns from Web Logs Based on Weight Constraint

Many frequent sequential traversal pattern mining algorithms have been developed which mine the set of frequent subsequences traversal pattern satisfying a minimum support constraint in a session database. However, previous frequent sequential traversal pattern mining algorithms give equal weightage to sequential traversal patterns while the pages in sequential traversal patterns have different importance and have different weightage. Another main problem in most of the frequent sequential traversal pattern mining algorithms is that they produce a large number of sequential traversal patterns when a minimum support is lowered and they do not provide alternative ways to adjust the number of sequential traversal patterns other than increasing the minimum support. In this paper, we propose a frequent sequential traversal pattern mining algorithm with weights constraint. Our main approach is to add the weight constraints into the sequential traversal pattern while maintaining the downward closure property. A weight range is defined to maintain the downward closure property and pages are given different weights and traversal sequences assign a minimum and maximum weight. In scanning a session database, a maximum and minimum weight in the session database is used to prune infrequent sequential traversal subsequence by doing downward closure property can be maintained. Our method produces a few but important sequential traversal patterns in session databases with a low minimum support, by adjusting a weight range of pages and sequence.
Genetic Evidence that EBNA-1 Is Needed for Efficient, Stable Latent Infection by Epstein-Barr Virus

ABSTRACT Replication and maintenance of the 170-kb circular chromosome of Epstein-Barr virus (EBV) during latent infection are generally believed to depend upon a single viral gene product, the nuclear protein EBNA-1. EBNA-1 binds to two clusters of sites at oriP, an 1,800-bp sequence on the EBV genome which can support replication and maintenance of artificial plasmids introduced into cell lines that contain EBNA-1. To investigate the importance of EBNA-1 to latent infection by EBV, we introduced a frameshift mutation into the EBNA-1 gene of EBV by recombination along with a flanking selectable marker. EBV genomes carrying the frameshift mutation could be isolated readily after superinfecting EBV-positive cell lines, but not if recombinant virus was used to infect EBV-negative B-cell lines or to immortalize peripheral blood B cells. EBV mutants lacking almost all of internal repeat 3, which encode a repetitive glycine and alanine domain of EBNA-1, were generated in the same way and found to immortalize B cells normally. An EBNA-1-deficient mutant of EBV was isolated and found to be incapable of establishing a latent infection of the cell line BL30 at a detectable frequency, indicating that the mutant was less than 1% as efficient as an isogenic, EBNA-1-positive strain in this assay. The data indicate that EBNA-1 is required for efficient and stable latent infection by EBV under the conditions tested. Evidence from other studies now indicates that autonomous maintenance of the EBV chromosome during latent infection does not depend on the replication initiation function of oriP. It is therefore likely that the viral chromosome maintenance (segregation) function of oriP and EBNA-1 is what is required.
Readthrough activation of early adenovirus E1b gene transcription

In cells productively infected with adenovirus type 5, transcription is not terminated between the E1a gene and the adjacent downstream E1b gene. Insertion of the mouse beta(maj)-globin transcription termination sequence (GGT) into the E1a coding region dramatically reduces early, but not late, E1b expression (E. Falck-Pedersen, J. Logan, T. Shenk, and J. E. Darnell, Jr., Cell 40:897-905, 1985). In the study described herein, we showed that base substitution mutations in the globin DNA that specifically relieved transcription termination also restored early E1b promoter activity in cis, establishing that maximal early E1b expression requires readthrough transcription originating from the adjacent upstream gene. To identify potential targets of readthrough activation, a series of recombinant viruses with double mutations was constructed. Each double-mutant virus strain had the transcription termination sequences in the first exon of E1a and a deletion within the transcription control region of E1b. Early E1b expression from the double-mutant strains was more defective than that from strains containing either mutation alone, indicating that the deleted regions (positions -362 to -35) are not the target for readthrough activation. Two findings suggested that a cis-dominant property of early viral templates is important for readthrough activation. First, the early E1b defect caused by the GGT insertion was not complemented in trans by factors present in late-infected cells. Second, restoration of E1b transcription at late times occurred concurrently with viral DNA replication. Readthrough activation may help convert virion DNA into a transcriptionally competent template prior to DNA replication and late transcription.
Design of folded cascode opamp using Potential Distribution Method

In this work, design of CMOS opamps using Potential Distribution Method (PDM) is discussed. PDM is a newly proposed device sizing technique for analog circuits based on voltage distribution at different nodes. This technique is free from complex mathematical expressions governing the devices and the circuit. Instead of relying on analytical design approach, PDM directly utilizes the simulator as a device sizing tool to meet the target specifications. This is achieved by first designing the circuit with moderate performance by logically or uniformly allocating node voltages and then modifying these node potentials to meet the target specifications. PDM is also technology independent and can be applied to both, long and short channel devices. A fully differential folded cascode opamp is then designed using PDM. Dependency of response of the opamp on different node voltages is discussed. It is shown how PDM can be employed to fine tune the opamp's response to meet the specifications and the simulation results are presented.
The use of medicinal plants in venous ulcers: a systematic review with meta‐analysis

The aim of this study was to systematically review the use of medicinal plants for the treatment of varicose ulcers. The databases used in the search were: Medline/Pubmed, Scopus, Cinhal, Lilacs and Web of Science. The selection process was divided into two phases: the reading of titles and abstracts and the full reading of selected articles. The item description was compared with the checklist of the Consolidated Standards of Reporting Trials. The initial search produced 3505 articles and seven were selected for inclusion in the systematic review. Of the included studies, 7 (100%) evaluated the reduction of the ulcer area, 4 (57·14%) evaluated reepithelisation, 2 (28·57%) evaluated bacterial flora and 1 (14·28%) evaluated the oxygen pressure and percutaneous carbon dioxide. The level of evidence rating indicated that five studies (71·42%) were rated at level 2 and two (28·57%) were rated at level 3. The quality assessment was performed using the Jadad scale, which is prevalent in the literature. The quality score of the Jadad questionnaire ranges from 0 to 5; here, the studies analysed had an average of 2·5. A meta‐analysis was performed on two studies that analysed the effects of Mimosa tenuiflora hydrogel in the treatment of venous ulcer and included 42 patients with a mean age of 60·5 years and a mean duration of treatment of 10·5 weeks. Heterogeneity was assessed using I2; we obtained a high value of 84%. We concluded that, despite the efficacy of the incorporation of Ageratina pichinchensis into the gel, the hydrogel that incorporated M. tenuiflora appeared to be a promising candidate for the management of venous ulcers.
Scaffolds for Dental Pulp Tissue Engineering

For tissue engineering strategies, the choice of an appropriate scaffold is the first and certainly a crucial step. A vast variety of biomaterials is available: natural or synthetic polymers, extracellular matrix, self-assembling systems, hydrogels, or bioceramics. Each material offers a unique chemistry, composition and structure, degradation profile, and possibility for modification. The role of the scaffold has changed from passive carrier toward a bioactive matrix, which can induce a desired cellular behavior. Tailor-made materials for specific applications can be created. Recent approaches to generate dental pulp rely on established materials, such as collagen, polyester, chitosan, or hydroxyapatite. Results after transplantation show soft connective tissue formation and newly generated dentin. For dentin-pulp-complex engineering, aspects including vascularization, cell-matrix interactions, growth-factor incorporation, matrix degradation, mineralization, and contamination control should be considered. Self-assembling peptide hydrogels are an example of a smart material that can be modified to create customized matrices. Rational design of the peptide sequence allows for control of material stiffness, induction of mineral nucleation, or introduction of antibacterial activity. Cellular responses can be evoked by the incorporation of cell adhesion motifs, enzyme-cleavable sites, and suitable growth factors. The combination of inductive scaffold materials with stem cells might optimize the approaches for dentin-pulp complex regeneration.
Construction and Mitigation of User-Behavior-Based Covert Channels on Smartphones

To protect user privacy, many smartphone systems adopt the permission-based mechanism in which a user can evaluate the risk of requests for private information from a mobile app before installing it. However, recent studies show that the permission based mechanism is vulnerable to application collusion attacks because two apps, which appear to be harmless individually, can establish a covert channel and use it to leak confidential information. Consequently, people have designed some covert channel detection schemes, by checking abnormal status of the phone. In this paper, we point out that existing covert channel detection schemes may fail to detect a new type of collusion attacks referred as user-behavior-based covert channels. We implement three covert channels on Android smartphones. Our work sets a new alarm for the security issue of using smartphones. We then study the countermeasures to this new type of covert channels. Instead of trying to directly detect the proposed new type of covert channels, we propose two mitigation solutions to reduce the effectiveness of such covert channels. The mitigation solutions are also valid to other existing sensor-based side channels and/or covert channels on the phone.