Miracle-dz/UniFAR-FTUs huggingface dataset:
Panel Review of Anaplastic Oligodendroglioma From European Organization for Research and Treatment of Cancer Trial 26951: Assessment of Consensus in Diagnosis, Influence of 1p/19q Loss, and Correlations With Outcome

Abstract The diagnosis of anaplastic oligodendroglioma (AOD) or anaplastic oligoastrocytoma (AOA) is subject to interobserver variation. The aim of this study was to estimate consensus in typing and grading of these tumors using tumor material collected in a large prospective randomized phase III study and to correlate the consensus diagnosis with the 1p/19q status of the tumors and the clinical outcome. The available pathology material of the first 150 patients, randomized into the European Organization for Research and Treatment of Cancer Trial 26951, was reviewed by an independent panel of 9 neuropathologists. The presence of deletions of 1p and 19q was assessed by fluorescence in situ hybridization with locus-specific probes. The panel reached consensus on the diagnosis of AOD in 52% of the tumors that had been diagnosed as AOD by the local pathologists, whereas only 8% of the local diagnosis of AOA was confirmed with consensus. The concordance on the panel diagnosis of AOD was high (intraclass correlation = 86%). The survival curves for AOD with 1p/19q loss, AOD without these losses, and AOA without 1p/19q loss ran separately in this order. The absence of necrosis and the presence of endothelial abnormalities were correlated with better outcomes. In multivariate analysis, patients' age, 1p/19q loss, and necrosis were identified as independent prognostic factors.
Early Time Course of Heart Rate Variability after Thrombolytic and Delayed Interventional Therapy for Acute Myocardial Infarction

In 89 of 97 consecutive patients with myocardial infarction (MI) undergoing thrombolysis and delayed early coronary angiography with PTCA, if indicated, heart rate variability (HRV) in time domain was evaluable 40 ± 11 h after the onset of chest pain using 24-hour ECG recordings. Patients with anterior MI (n = 40) had lower values for HRV and left ventricular ejection fraction (p < 0.05). The mean of all 5-min standard deviations of RR intervals (SDNNi) and the root-mean-square difference of successive RR intervals (rMSSD) decreased significantly (p < 0.001 each), whereas the standard deviation of all normal RR intervals and the percentage of absolute differences between successive RR intervals only showed a tendency to lower values 4 weeks after MI (p = 0.20 and 0.08, respectively). The decreases in SDNNi and rMSSD were more evident in inferior than in anterior MI. The time course of HRV following MI was similar in patients with and without PTCA. These results indicate an initial vagal hyperactivity in inferior MI, which is quickly predominated by sympathetic activation and a prolonged recovery of the cardiac autonomic imbalance after MI despite a successful combined reperfusion therapy.
Other-Regarding Principal and Moral Hazard

Using the classic moral hazard problem with limited liability we characterize the optimal contracts when an other-regarding principal interacts with a self-regarding agent. The optimal contract differs considerably when the principal is ‘inequity averse’ vis-a-vis the self-regarding case. Also the agent is generally (weakly) better-off under an ‘inequity- averse’ principal compared to a ‘status seeking’ principal.
Prelaunch Calibration of Microwave Humidity Sounder on China's FY-3A Meteorological Satellite

China's Feng Yun-3A (FY-3A) meteorological satellite is a second-generation polar-orbiting meteorological satellite launched in May 2008. The Microwave Humidity Sounder (MWHS) is the main payload, designed for atmospheric humidity sounding. Before the launch of MWHS, a series of experiments was conducted in a thermal/vacuum (T/V) chamber. This letter describes the MWHS T/V calibration, in which the flight model currently operating on FY-3A was tested. The calibration procedure and data-processing methods are presented. Calibration results, such as radiometric resolution, receiver nonlinearity, and calibration bias, were obtained. The results meet the specifications on bias and sensitivity of MWHS. Since the instrument temperatures will be approximately 10°C-20°C on orbit, the calibration errors of MWHS over the range of 100-300 K would be less than 0.3 K using the nonlinearity coefficients derived in the T/V test.
A neotype implemention method for CRS-based logic gates in crossbar array

Recently, researchers have demonstrated that memristors can be used to implement latches and memory as well as programmable interconnects, logic circuits are also important application using memristors. In this paper, we propose a novel design for complementary resistive switch based stateful logic architecture. In the proposed method, five basic logic operations can be applied to passive crossbar arrays, which offered huge benefits in terms of scalability and area consumption. In addition, multi-input logic operation can be implemented successfully. Moreover, the proposed design applying CRS may reduce sneak paths, which corresponds to parasitic current paths that bypass the target storage element and may cause the array to be nonfunctional.
The Epidemiology of Fatal road traffic Collisions in Trinidad and Tobago, West Indies (2000–2011)

Summary of what was known • Few studies on road traffic collisions conducted in Latin American and the Caribbean region • Increasing car ownership within the region • Lack of seatbelt usage in Trinidad • Most accidents are associated with alcohol usage • High mortality among pedestrians Summary of what this study adds • Most collisions occur at night • Most collisions occur at weekends • Collisions are evenly distributed throughout the year • More males than females die in fatal collisions • The most productive age group (15–44) is affected the most • More drivers than pedestrians are affected • Reflects the pattern of developed rather than developing countries with respect to time of day for RTCs Background The purpose of the study is to determine the epidemiology of road traffic collisions (RTCs) in Trinidad and Tobago by characterizing RTCs in terms of number of collisions, fatalities, victim profiles, and locations for the purpose of informing accident prevention programs. Previous studies of RTCs in Trinidad and Tobago were primarily concerned with patterns of drivers use of seat belts, road collisions as a cause of mortality in young men, and the economic burden of road collisions. Attempts were made to model road fatalities, but limited epidemiological data meant that it was difficult to determine trends or develop models. Methods This study determined the epidemiology of RTCs in Trinidad and Tobago over the period 2000–2011using data collected by the Trinidad and Tobago Road Traffic Branch of the Police Service and secondary data from the Central Statistical Office. Data were analyzed using Excel, SPSS, and R statistical packages. Results Fatalities were greater among men (80%) than among women (20%) and were highest on two major freeways in Trinidad [the Churchill–Roosevelt Highway and the Sir Solomon Hochoy Highway]. Most collisions occurred during the night among individuals between the ages of 15 and 44 years. Fatalities among drivers steadily increased over the study period and overtook fatalities among pedestrians, who were the group most affected in 2000. Most fatalities occurred at weekends. Conclusions These patterns can inform (i) education programs and (ii) road and traffic control measures.
An Improved Protocol of Biotinylated Tyramine-based Immunohistochemistry Minimizing Nonspecific Background Staining

An immunohistochemical method using biotinyl tyramine was recently introduced to amplify weak staining signals. Despite its high sensitivity, however, tyramine-based immunostaining has been limited by its increased background staining. In this study, to develop an improved protocol of biotinyl tyramine-based immunohistochemistry minimizing the background staining, we determined which staining steps lead to the nonspecific reaction and the most appropriate blocking agents for background-provoking steps. Trypton casein peptone and distilled water with Tween-20 were shown to be most effective as a blocking agent and a rinsing solution, respectively. In conclusion, we developed an optimized protocol for biotinyl tyramine-based immunohistochemistry with minimal background staining.
Shadows of the Past

Following research on transition economies in Central and Eastern Europe (CEE), and having been motivated by arguments pertaining to the business systems approach, the authors propose that the existence of a communist heritage decreases the likelihood that employees will be consulted during organizational change processes. Results based on 23,876 firms across 27 of the European Union (EU-27) countries support this proposition. Moreover, the likelihood of direct consultation decreases with the existence of formal employee representation and an increasing share of foreign ownership in firms located in CEE countries. The authors discuss these findings in the context of organizational democracy research and the recent literature on transition economies and contribute to a more comprehensive understanding of participative decision-making processes in organizations.
Is an Incentive Policy for Energy Efficient Products Effective for Air Purifiers? The Case of South Korea

Recent increases in fine and ultrafine dust in South Korea have led to sharp increases in the sale of air purifiers, and that trend is expected to continue. As the sale of air purifiers increases, the energy that is consumed by air purifiers also increases. Therefore, improving the energy efficiency of air purifiers is an important part of improving the overall energy efficiency of society. We studied how different incentive policies affect consumer behavior because encouraging people to buy energy efficient air purifiers is important. We first investigated consumer preferences regarding air purifiers. Stated preference data were gathered from a choice experiment and a mixed logit model was used for the analysis. The results show that the most preferred attribute was price, followed by an eco-label. Based on that result, we conducted a scenario analysis to examine the economic and environmental effects of an incentive policy and eco-labeling. The monetary incentive policy increased the market share for air purifiers with a first-grade energy efficiency rating to 2.2%. The annual electricity use reduction was 5.9 GWh, with a CO2 emission reduction of 2520 tons and a policy monetary benefit of KRW 441,340,922 when we converted the effect of that market share change into economic and environmental terms. Eco-labeling also brought considerable change in the market share. These results provide a reference for implementing policies to encourage consumers to purchase energy efficient air purifiers.
Genomic and evolutionary diversity of LTR retrotransposons in date palm (Phoenix dactylifera)

Of the transposable elements (TEs), the retrotransposons are the most copious elements identified from many sequenced genomes. They have played a major role in genome evolution, rearrangement and expansions based on their copy and paste mode of proliferation. They are further divided into LTR and Non-LTR retrotransposons. The purpose of the current study was to identify the LTR REs in sequenced Phoenix dactylifera genome and to study their structural diversity. A total of 150 P. dactylifera BAC sequences with >60kb sizes were randomly retrieved from NCBI database and screened for the presence of LTR retrotransposons. Seven BAC sequences showed full length LTR Retrotransposons with 4 Copia and 3 Gypsy families having variable copy numbers in respective families. Reverse transcriptase (RT) domain was found as the most conserved domain among Copia and Gypsy superfamilies and was used to deduce evolutionary analysis. The amino acid residues among various RT sequences showed variability in their percentages indicating post divergence evolution. Amino acid Leucine was found in highest proportions followed by Lysine, while Methionine and Tryptophan were in lowest percentages. The phylogenetic analysis based on RT domains confirmed that although having most conserved RT regions, several evolutionary events occurred causing nucleotide polymorphisms and hence clustering of Gypsy and Copia superfamilies into their respective lineages. The study will be helpful in identification and annotation of these elements in other species and genera and their distribution patterns on chromosomes by florescent in situ hybridization techniques.
Reflecting on e-Recruiting Research: a Systematic Literature Review

paper presents a systematic review of e-Recruiting literature by using the grounded theory approach. The increasing number of recent publications and attention paid to e- Recruiting research as the most studied field within eHRM (Electronic Human Resource Management) calls for synthesizing the major achievements, methods used, gaps and future research directions. We provide an overview of state-of- the-art e-Recruiting research, and discuss directions to advance e-Recruiting research and practice. KeywordsReview, e-Recruiting, Future Research Directions.
Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase

We investigated the possible effects of placental alkaline phosphatase (PLAP) genotype on the deleterious action of maternal smoke on intrauterine survival and birthweight. PLAP is a highly polymorphic enzyme with several alleles associated with different enzymatic activities. PLAP is produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy. Two hundred and fourteen Caucasian consecutive newborn infants delivered in the Maternity Department of the University of Rome La Sapienza Hospital were studied. Infants from smoking women 28 years or older show a strong decrease of both PLAP*1/*1 and *2/*2 homozygous types and a marked deviation from Hardy‐Weinberg expectation, thus suggesting a different lethal effect of smoke depending on PLAP genotype and maternal age. In infants from smoking mothers there is a decrease of birthweight that is much less evident and statistically not significant in infants carrying the PLAP*1/*1 genotype as compared to other genotypes. The difference between PLAP genotypes concerning birthweight is more marked in women older than 28 years than in younger ones. This suggests that the effects of smoke on birthweight are also dependent on PLAP and maternal age. Am. J. Hum. Biol. 15:781–785, 2003. © 2003 Wiley‐Liss, Inc.
urgeon Distress as Calibrated by Hours Worked nd Nights on Call

BACKGROUND: The relationships of working hours and nights on call per week with various parameters of distress among practicing surgeons have not been previously examined in detail. STUDY DESIGN: More than 7,900 members of the American College of Surgeons responded to an anonymous, cross-sectional survey. The survey included self-assessment of their practice setting, a validated depression screening tool, and standardized assessments of burnout and quality of life. RESULTS: There was a clear gradient between hours and burnout, with the prevalence of burnout ranging from 30% for surgeons working 60 hours/week, 44% for 60 to 80 hours/week, and 50% for those working 80 hours/week (p 0.001). When correlated with number of nights on call, burnout exhibited a threshold effect at 2 nights on call/week ( 1 nights on call/week, 30%; 2 nights on call/week, 44% to 46%; p 0.0001). Screening positive for depression rate also correlated strongly with hours and nights on call (both p 0.0001). Those who worked 80 hours/week reported a higher rate of medical errors compared with those who worked 60 hours/week (10.7% versus 6.9%; p 0.001), and were twice as likely to attribute the error to burnout (20.1% versus 8.9%; p 0.001). Not surprisingly, work and home conflicts were higher among surgeons who worked longer hours or had 2 nights on call. A significantly higher proportion of surgeons who worked 80 hours/week or had 2 nights on call/week would not become a surgeon again (p 0.0001). CONCLUSIONS: Number of hours worked and nights on call per week appear to have a substantial impact on surgeons, both professionally and personally. These factors are strongly related to burnout, depression, career satisfaction, and work and home conflicts. ( J Am Coll Surg 2010;211: 609–619. © 2010 by the American College of Surgeons)
Seamless transmission management control based on geocast-based inter-vehicle communications

After several years of development, Vehicular ad hoc Networks (VANETs) are now an emerging Telematics environment. Applications have been studied in many fields, including fleet management, vehicle tracking, and driver warming systems. This study proposes a seamless fleet transmission management control mechanism for VANETs. The proposed fleet management process, defined the fleet area by dynamic geocast region, and offers seamless steady inter-vehicle communication according to one-way freeway conditions and vehicle status, including velocity and transmission distance. For in inter-vehicle communication, the conventional defer time algorithm was modified to reduce the problem of frequent network fragmentation and to predict when vehicles are within transmission range and to discovery, new relay vehicles before network fragmentation occurs. The proposed transmission management system provides reliable inter-vehicle communication for a dynamic fleet.
Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung

ABSTRACT Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.
Removing Distortions in the U.S. Ethanol Market: What Does it Imply for the United States and Brazil?

We analyze the impact of trade liberalization and removal of the federal tax credit in the United States on ethanol markets using a multimarket international ethanol model. We find that U.S. trade barriers have been effective in protecting the ethanol industry. Under current policy, there is separability of the U.S. ethanol market from world markets. With trade liberalization, the ethanol market deepens, making it less susceptible to price volatility. The effect of trade liberalization extends beyond ethanol markets, affecting agricultural markets. The results show that the impact of removal of the tax credit overrides the impact of the tariff removal. Copyright 2008, Oxford University Press.
Reliability and validity of the Yoruba version of the Oswestry disability index

Context: Low back pain (LBP) is a major cause of disability, and the Oswestry Disability Index (ODI) is a validated assessment tool for evaluating disability in LBP patients. Cross-cultural adaptation of the ODI is important because not all populations are proficient in English. The Yoruba language is an indigenous language spoken by 40 million people in the Western part of Nigeria and some countries in West Africa and Latin America. Currently, no validated Yoruba version of ODI is available. Aims: The aim of the study was to translate, culturally adapt and validate the ODI in Yoruba language for participants with LBP. Subjects and Methods: The ODI was translated into Yoruba, and this translated version was analysed in terms of semantics and linguistics. Then, the Yoruba version was translated back into English and both versions administered to 160 participants with LBP. The internal consistency using Cronbach's alpha coefficient, criterion validity and test–retest reliability were assessed using Spearman's rank correlation with significance set at P< 0.05. The inter-rater reliability was evaluated by two different observers and the intra-rater reliability was determined by the same observer, a week apart. Results: The internal consistency of the Yoruba ODI with Cronbach's alpha was 0.97, the intrarater reliability yielded an intraclass correlation coefficient of 0.93 and criterion validity assessed using Spearman's rank correlation was r = 0.92 for highest score and 0.63 for lowest score. Conclusion: The Yoruba ODI is a reliable and valid tool for assessing functional disability in LBP patients.
“DTH 1.0”: TOWARDS AN ARTIFICIAL INTELLIGENCE DECISION SUPPORT SYSTEM FOR GEOGRAPHICAL ANALYSIS OF HEALTH DATA

The complexity of modern scientific research requires advanced approaches to handle and analyse rich and dynamic data. Organizations such as hospitals, hold a great number of health datasets which may consist of many individual records. Artificial Intelligence methodologies incorporate approaches for knowledge retrieval and pattern discovery, which have been proven to be useful for data analysis in various disciplines. Decision trees methods belong to knowledge discovery methodologies and use computational algorithms for the extraction of patterns from data. This work describes the development of an autonomous Decision Support System (“Dth 1.0”) for the real-time analysis of health data with the use of decision trees. The proposed system uses a patient's dataset based on the patients’ symptoms and other relevant information and prepares reports about the importance of the characteristics that determine the number of patients of a specific disease. This work presents the basic concept of decision trees, describes the design of a tree-based system and uses a virtual database to illustrate the classification of patients in a hypothetical intra-hospital case study.
Psychological profiles in patients with Sjögren's syndrome related to fatigue: a cluster analysis.

OBJECTIVE Fatigue is a highly prevalent and debilitating symptom in the autoimmune disease SS. Although the disease process plays a role in fatigue, psychological factors may influence fatigue and the ability to deal with its consequences. Profiles of co-occurring psychological factors may suggest potential targets for the treatment of fatigue. The aim of this study was to identify psychological profiles in patients with SS and the accompanying levels of fatigue. METHODS Three hundred patients with primary SS (mean age 57 years, 93% female) completed questionnaires on fatigue (multidimensional fatigue inventory), physical activity cognitions (TAMPA-SK), illness cognitions, cognitive regulation, emotion processing and regulation [Toronto Alexithymia Scale 20, Emotion Regulation Questionnaire (ERQ), Berkeley Expressivity Questionnaire], coping strategies (Brief COPE) and social support. RESULTS Principal axis factor analysis (oblimin rotation) yielded six psychological factors: social support, negative thinking, positive thinking, emotional expressivity, avoidance and alexithymia (i.e. the inability to differentiate emotions). Using cluster analyses, these factors were grouped in four psychological profiles: functional (39%), alexithymic (27%), self-reliant (23%) and dysfunctional (11%). Irrespective of the psychological profile, the level of fatigue was substantially higher in patients than in the general population. Patients with a dysfunctional or an alexithymic profile reported more fatigue than those with a self-reliant profile. CONCLUSION Our study in SS yielded four psychological profiles that were differentially associated with fatigue. These profiles can be used to examine determinants and prognosis of fatigue as well as the possibility of customizing cognitive behavioural interventions for chronic fatigue.