Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Allanblackia floribunda stem-bark Extracts on Oxidative stress and Mitochondrial Dysfunction in Rats Exposed to Crude Oil

The development of degenerative diseases has been linked to oxidative stress and mitochondrial dysfunction. Additionally, it has been demonstrated that the changes caused by crude oil exposure contribute to the onset of degenerative diseases. There is little or no information on the anti-degeneration properties of Allanblackia floribunda. This study was carried out to investigate brain mitochondrial tissues exposed to crude oil and the effects of A. floribunda as a preventive and therapeutic intervention against oxidative stress and mitochondrial dysfunction. Twenty-five Wistar rats were divided into five groups: the control group received distilled water, the second group received ethanol extracts of A. floribunda, the third group received crude oil (5 mL/kg), the fourth and fifth groups received crude oil and A. floribunda extract concurrently (200 and 400 mg/kg, respectively). The results showed that crude oil treatment caused a significant increase in brain mitochondrial MDA levels and induced significant alterations in brain mitochondrial antioxidant enzyme activities compared with control. Treatment with the extract alone revealed a significant increase in protein carbonyl, conjugated dienes, and ATPases compared with crude oil-treated rats. This indicates that A. floribunda inhibited crude oil-induced mitochondrial lipid peroxidation and improved ATPase and antioxidant status in the rat brain mitochondria, which further suggests that A. floribunda possesses potential and may efficiently inhibit crude oil-induced oxidative damage and improve mitochondrial functions.
The Elongator Subunit Elp3 Regulates Development, Stress Tolerance, Cell Cycle, and Virulence in the Entomopathogenic Fungus Beauveria bassiana

Transcriptional activity is mediated by chromatin remodeling, which in turn is affected by post-translational modifications, including histone acetylation. Histone acetyltransferases (HATs) are capable of promoting euchromatin formation and then activating gene transcription. Here, we characterize the Elp3 GNAT family HAT, which is also a subunit of Elongator complex, in the environmentally and economically important fungal insect pathogen, Beauveria bassiana. BbElp3 showed high localization levels to mitochondria, with some nuclear and cytoplasmic localization also apparent. Targeted gene knockout of BbElp3 resulted in impaired asexual development and morphogenesis, reduced tolerances to multiple stress conditions, reduced the ability of the fungus to utilize various carbon/nitrogen sources, increased susceptibility to rapamycin, and attenuated virulence in bioassays using the greater wax moth, Galleria mellonella. The ΔBbElp3 mutant also showed disrupted cell cycle, abnormal hyphal septation patterns, and enlarged autophagosomes in vegetative hyphae. Transcriptome analyses revealed differential expression of 775 genes (DEGs), including 336 downregulated and 438 upregulated genes in the ΔBbElp3 strain as compared to the wild type. Downregulated genes were mainly enriched in pathways involved in DNA processing and transcription, cell cycle control, cellular transportation, cell defense, and virulence, including hydrophobins, cellular transporters (ABC and MFS multidrug transporters), and insect cuticular degrading enzymes, while upregulated genes were mainly enriched in carbohydrate metabolism and amino acid metabolism. These data indicate pleiotropic effects of BbElp3 in impacting specific cellular processes related to asexual development, cell cycle, autophagy, and virulence.
Combining Synchronous and Asynchronous Learning: Student Satisfaction with Online Learning using Learning Management Systems

Students' satisfaction, knowledge, skills and attitude towards learning (KSAs), engagement and interaction in online learning are essential indicators in ensuring that the Learning Management System (LMS) is utilised effectively and efficiently. However, most students become passive listeners and observers during online teaching and learning activities on the LMS platform, both in synchronous and asynchronous learning. Therefore, this study aimed to identify student satisfaction in terms of KSAs, engagement and interaction with a combination of synchronous and asynchronous learning in online learning platforms. A questionnaire was distributed to 163 students from a higher education institution. The results showed that student satisfaction was at a high level in KSAs; there was a significant positive relationship between KSAs, interaction and student engagement which led to student satisfaction. Therefore, a teaching design which combines synchronous and asynchronous learning methods could be applied by educators to enhance students' KSAs, interaction and engagement to help raise their satisfaction levels.
Suicide Potential and Depression: Risk and Protective Factors among College Students in the Philippines

The study evaluated the level of suicide potential and depression among college students including the risk and protective factors for suicide. Descriptive correlational method was used where 915 respondents participated in this study. Three standardized tests were used to test the level of suicide potential, level of depression, and the importance of the risk and protective factors. Results showed that suicide potential among students was moderate to high and the level of depression was average. It also revealed that family alliance and self-acceptance were among the significant risks and protective factors to the respondents and that depression was significantly associated with suicide potential. The results implied that there are substantial number of students with high level of depression and high level of suicide potential that may need clinical intervention. This study suggests that the guidance, counseling, and psychological services should include not only the guidance counselors but also the psychologists and psychiatrists to cater to those who need thorough psychological intervention.
The Role of the Human Gut Microbiome in Inflammatory Bowel Disease and Radiation Enteropathy

The human gut microbiome plays a key role in regulating host physiology. In a stable state, both the microbiota and the gut work synergistically. The overall homeostasis of the intestinal flora can be affected by multiple factors, including disease states and the treatments given for those diseases. In this review, we examine the relatively well-characterised abnormalities that develop in the microbiome in idiopathic inflammatory bowel disease, and compare and contrast them to those that are found in radiation enteropathy. We discuss how these changes may exert their effects at a molecular level, and the possible role of manipulating the microbiome through the use of a variety of therapies to reduce the severity of the underlying condition.
South Eastern Busway Network in Brisbane, Australia: Value of the Network Effect

This paper identifies how much was added to residential land values through the provision of bus rapid transit (BRT) service in Brisbane, Queensland, Australia, with regard to increases in land values because of the BRT system itself and the value of the network effect as a result of incremental additions to the transport infrastructure, a much more common feature of Australian cities. Difference-in-differences models were employed to explore whether there were significant differences between the treatment group (properties close to busway stations) and the control group (properties not close to busway stations) with regard to housing price changes (first difference) before and after the opening of busway stations (second difference). Two types of control groups were defined by using conventional buffer methods and propensity score matching. Model results show increases in property prices because of better accessibility to busways themselves, on the one hand, and on the other hand, additions to the value of land through the network effect of access to a greater service area as the BRT network is developed. The paper reports how different methods of identifying control areas to match given treatment areas had different results and discusses the implications of these results for a literature that has a variety of methods established for research.
Two problems in finite elasticity

Some materials encountered in nature and used in engineering exhibit mechanical effects which cannot be adequately explained by classical linear elastic theories. For example, rubber is an elastic material that undergoes large elastic deformations, and therefore renders a non-linear mechanical behavior. An analytical investigation dealing with the problem of static deformation of such materials therefore involves highly non-linear equations leading to arduous mathematical work. Consequently there exists only a limited number of known exact solutions for such problems in the field of finite elasticity. This thesis is concerned with two problems of finite elastic deformations of rubber blocks. Rubber has been successfully modeled as an isotropic incompressible hyperelastic material with strain energy function given by either the neo-Hookean or Mooney forms. For this class of materials, substantial reductions of the basic underlying equilibrium equations can be obtained, making the problems more tractable and for plane and axially symmetric deformations of these materials, simpler stressstrain relations can be obtained. Therefore, by combining these essentially twodimensional stress-strain relations together with the reduced equilibrium equations it is possible to obtain comparatively tractible forms of the equations. In this thesis the following problems for axially symmetric deformations of isotropic incompressible neo-Hookean and Mooney materials are investigated: (i) asymptotic axially symmetric deformations describing compression of rubber cylindrical tubes with bonded metal end plates; (ii) rippling of a long rectangular rubber block bent into a sector of a solid bounded by two circular arcs. The above mentioned reduced equllibrium equations are employed in the context of non-linear continuum mechanics to arrive at approximate solutions. The solutions are approximate in the sense that the point-wise vanishing of the stress vector on a boundary is assumed to be replaced by the vanishing of forces in an average manner. In the first problem, for axially symmetric deformations of the perfectly elastic neo-Hookean and Mooney materials, formal asymptotic solutions are determined in terms of expansions in appropriate powers of 1/R, where R is the cylindrical
HPV Vaccination and Cervical Cancer Screening: Assessing Awareness, Attitudes, and Adherence in Detained Women

Background: This study assessed awareness, attitudes, and uptake of human papillomavirus (HPV) vaccination and cervical cancer screening in detained women. Methods: The cross-sectional study was conducted from April to June 2022 in four women prisons in Italy. Results: 41.1% of participants recognized HPV infection as an sexually transmitted diseases (STD), 36.4% identified cervical, and 16.8% oral cancer as an HPV-associated disease. Overall, 70% had never heard of HPV vaccination, and 45.8% believed it is effective to prevent cervical cancer. Among the age-eligible women for HPV vaccination, none reported to have undergone it, nor had talked about it with a physician in the previous year. Only 13.5% declared to have ever undergone cervical cancer screening, and adherence was significantly higher in those who were involved in a working activity in prison, who were aware that HPV infection is an STD and that can cause cervical and oral cancer, and who were older at their first sexual intercourse. Conclusion: These findings documented an extremely low awareness of HPV infection and an unsatisfactory adherence to prevention through HPV vaccination and cervical cancer screening. There is a need for evidence-based interventions for incarcerated women to promote participation in HPV vaccination and cervical cancer screening programs as routine activities.
Customer experience and commitment on eWOM and revisit intention: A case of Taladtongchom Thailand

Abstract This study examines the effects of customer experience on electronic word of mouth (eWOM) and revisit intention and investigates whether commitment mediates the relationship between customer experience, eWOM, and revisit intention in the tourism context. A survey method by using a self-administered questionnaire with a quantitative approach was conducted. Quota sampling was adopted, the data were collected in 12 markets, for a total of 52 questionnaires per market. The total sample sizes are 624 tourists. Structural equation modeling (SEM) is used for data analysis. The results indicate that customer experience has a significant and positive relationship with affective and continuance commitment. Affective commitment mediates the relationship between entertainment and escapist experience and eWOM and revisit intention. The study’s findings the extended role of customer experience and the types of commitment provide meaningful theoretical implications. Hence, managers should focus on customer experience to generate customers’ commitment, positive eWOM, and revisit intention.
High Seroprevalence against SARS-CoV-2 among Dogs and Cats, Poland, 2021/2022

Simple Summary The coronavirus SARS-CoV-2 is responsible for the COVID-19 pandemic, which has kept the world in suspense since the beginning of 2020. Infected owners can transmit the virus to their cats and dogs, but it is not exactly known how often this happens. Here, we investigated samples from cats and dogs that live in households in Poland for antibodies against the virus. Antibodies are produced subsequently to a SARS-CoV-2 infection and can be detected for much longer than the virus itself. We found that approximately 18.9% of the cats and 16.0% of the dogs sampled had previously come into contact with the virus and developed antibodies. This suggests a continuous occurrence of virus transmission from infected owners to their pets. Abstract The coronavirus SARS-CoV-2 is responsible for a pandemic in the human population that has unfolded since the beginning of 2020 and has led to millions of deaths globally. Apart from humans, SARS-CoV-2 has been confirmed in various animal species, including felines, canines, mustelids, and primates. Of these species, dogs and cats are the most popular companion animals worldwide. Several seroprevalence studies have already been performed in these animal species; however, the results vary depending on the location and especially the time of sampling. Here, serum samples were collected from a total of 388 dogs and 243 cats from three veterinary clinics in two cities (Gdańsk and Olsztyn) in Poland between October 2021 and February 2022, when the country was in the midst of the fourth wave of viral spread. All sera were tested for antibodies against SARS-CoV-2 by a multispecies ELISA based on the receptor-binding domain and by an indirect immunofluorescence assay (iIFA). Overall, 18.9% of the feline sera and 16.0% of the canine sera tested positive using ELISA and iIFA. This relatively high seroprevalence among randomly selected animals is most likely related to the high case numbers in the human population and indicates a continuous occurrence of transspecies virus transmissions from infected owners to their pets. Hence, dogs and cats should be included in monitoring studies and/or outbreak investigations for a better understanding of the epidemiology of this virus.
Association of Antihypertensive Effects of Esaxerenone with the Internal Sodium Balance in Dahl Salt-Sensitive Hypertensive Rats

Background: The nonsteroidal mineralocorticoid receptor blocker esaxerenone is effective in reducing blood pressure (BP). Objective: In this study, we investigated esaxerenone-driven sodium homeostasis and its association with changes in BP in Dahl salt-sensitive (DSS) hypertensive rats. Methods: In the different experimental setups, we evaluated BP by a radiotelemetry system, and sodium homeostasis was determined by an approach of sodium intake (food intake) and excretion (urinary excretion) in DSS rats with a low-salt diet (0.3% NaCl), high-salt diet (HSD, 8% NaCl), HSD plus 0.001% esaxerenone (w/w), and HSD plus 0.05% furosemide. Results: HSD-fed DSS rats showed a dramatic increase in BP with a non-dipper pattern, while esaxerenone treatment, but not furosemide, significantly reduced BP with a dipper pattern. The cumulative sodium excretion in the active period was significantly elevated in esaxerenone- and furosemide-treated rats compared with their HSD-fed counterparts. Sodium content in the skin, skinned carcass, and total body tended to be lower in esaxerenone-treated rats than in their HSD-fed counterparts, while these values were unchanged in furosemide-treated rats. Consistently, sodium balance tended to be reduced in esaxerenone-treated rats during the active period. Histological evaluation showed that esaxerenone, but not furosemide, treatment attenuated glomerulosclerosis, tubulointerstitial fibrosis, and urinary protein excretion induced by high salt loading. Conclusions: Collectively, these findings suggest that an esaxerenone treatment-induced reduction in BP and renoprotection are associated with body sodium homeostasis in salt-loaded DSS rats.
Unemployment Anxiety in Light of the Coronavirus 2019 Pandemic and Its Relationship to Psychological Reassurance among Graduate Students at Prince Sattam Bin Abdulaziz University

This research explored the effects of the COVID-19 pandemic on increasing the unemployment anxiety levels of graduate students at Prince Sattam Bin Abdulaziz University. To fulfill the objective of this study, 120 graduate students at the mentioned university were selected based on the convenience sampling method as the participants of the study. Sixty participants lost their jobs during the Coronavirus 2019 pandemic, but the rest had jobs. After determining the participants’ job conditions, the researchers administered Zung’s (1971) anxiety questionnaire via e-mail, Telegram, WhatsApp, Microsoft Teams, Zoom, WeChat, Google Meetings, and other social media platforms. One hundred and seven students (56 employed and 51 unemployed) completed the questionnaire and sent it back to the researchers. The parametric results divulged a notable difference between the anxiety level of the employed and unemployed groups, implying that the unemployed participants had much more anxiety during the Coronavirus 2019 pandemic. The implications of this research can be compelling for governments to take practical actions during fatal disasters such as the COVID-19 pandemic.
Tourism employee resilience, organizational resilience and financial performance: the role of creative self-efficacy

Abstract Despite the recognition that employee resilience affects the resilience of tourism organizations, the influence of employees’ creative self-efficacy on their own resilience and the subsequent effects on organizational resilience has yet to be ascertained. We use social cognitive theory to argue that creative self-efficacy and employee resilience have positive impacts on organizational resilience (planned and adaptive) and firms’ financial performance. We test these propositions among 478 tourism and hospitality organizations affected by COVID-19 in Sri Lanka. Results suggest that employees’ creative self-efficacy have a significant positive influence on employee resilience and planned resilience but, contrary to our predictions, lessens adaptive resilience and financial performance. Employee resilience only affects planned resilience but not adaptive resilience. Employee resilience and adaptive resilience have positive influences on financial performance of the firm. The findings have implications on how human capital development can contribute to sustainable tourism development. Implications for practice are also offered.
Characteristics of the Intraseasonal Oscillation in the Equatorial Mesosphere and Lower Thermosphere Region Revealed by Satellite Observation and Global Analysis by the JAGUAR Data Assimilation System

Climatological features of the intraseasonal oscillation (ISO) in the equatorial mesosphere and lower thermosphere were analyzed using temperature data from the Aura Microwave Limb Sounder (MLS) and global analysis data from a data assimilation using satellite observations, including the MLS, over 15 years. Based on spectral analyses, fluctuations with a period of 15–90 days were extracted as the ISO component. First, an empirical orthogonal function (EOF) analysis was performed for the ISO components of the zonal mean temperature from the MLS in the region of 10°S–10°N, 68–85 km, where the ISO amplitudes are found to be maximized. The global structure of the ISO anomalies of temperature and zonal winds estimated assuming a gradient wind balance was examined by a regression analysis using the first and second principal EOFs. It is shown that the ISO phases propagate downward with a vertical wavelength of 25–30 km above a height of 60 km and that the ISO signal synchronized with the equatorial ISO is observed even in the middle and high latitude regions of both hemispheres. Second, the global analysis data were used to examine the driving mechanism of the ISO. It was confirmed that the time series of the equatorial ISO zonal mean zonal wind in the analysis agreed well with radar observations, which were not used for assimilation. Results suggest small‐scale phenomena, such as gravity waves not necessarily represented in the parameterization and the meridional advection of angular momentum, mainly contribute to drive the ISO.
Three-gluon vertex in Landau gauge

We present the first Dyson–Schwinger calculation of the three-gluon vertex in Landau-gauge QCD in which its full covariant structure is back-coupled self-consistently. We truncate a Bose-symmetrized version of the Dyson–Schwinger equation at the level of one-loop diagrams, model the four-gluon vertex, and neglect terms that contain nonprimitively divergent n -point functions; the ghost-gluon vertex is taken bare to good approximation. Fit functions for the ghost and gluon propagators that interpolate between scaling and decoupling are presented. In all aspects of our study, Bose symmetry is manifest, from the truncation to the basis decomposition and to the momentum invariants. We explore the uniform and soft-collinear infrared limits and obtain the expected infrared exponents. The presence of a zero crossing in the tree-level component of the vertex is confirmed for both scaling- and decoupling-type scenarios. The zero crossing appears at a scale ∼ 1 GeV ; however, its location might be sensitive to the four-gluon vertex and missing components in the Dyson–Schwinger equation.
Influence of the volute cross-sectional shape on mixed inflow turbine performances

The volute is an essential element in the centrifugal machines. Improving its performance is an effective way to improve the total performance of the turbine. The purpose of this study is to replace the accelerating and guiding nozzle vanes by exploring different design possibilities on the cross-sectional area convergence of the volute, since a decreasing area is then associated with expansion in the subsonic regime. The work is extended to a mixed inflow turbine using the new volute cross sections under pulsating regimes for turbocharging. The numerical simulation results show larger accelerations ( M 2 ≈ 0 . 95 ) and lesser losses in the case of sections with flatter area in the radial direction and without vaneless space between the volute and the rotor; but this combination has an effect on the exit absolute flow angle which is less uniform.