Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct and indirect contributions of child difficult temperament and power assertive parental discipline to Turkish children’s behaviour problems

ABSTRACT The purpose of the current study was to examine power assertive parental discipline and child difficult temperament as predictors of children’s behaviour problems (internalizing, externalizing, and total behaviour problems) as well as mediating role of difficult temperament between power assertive parental discipline and children’s behaviour problems. Participants were 118 children (53 boys) and their parents for the current study. Children’s age ranged from 16 months to 36 months (M = 27.91, SD = 5.67). Mothers reported on their power assertive parental discipline, child temperament, and behaviour problems of children. Results from regression analysis showed that: (1) there was a positive association between parents’ power assertive discipline and child behaviour problems. (2) Child difficult temperament was positively associated with children’s internalizing, externalizing and total behaviour problems. (3) Children’s difficult temperament mediated the association between power assertive discipline and child behaviour problems. Limitations and future directions of the current study are discussed.
Detection of mRNA of CDKN2A, MKi67 and TOP2A in liquid-based cytology as biomarker of high grade lesions of uterine cervix

Introduction/Background It has been suggested that the evaluation of the expression of host-cell genes involved in cervical carcinogenesis induced by high-risk human papillomavirus (HR-HPV) may be useful to identify patients harbouring high-grade squamous intraepithelial lesions (HSIL). We aimed to evaluate the performance of mRNA detection of three biomarkers (CDKN2A, MKi67, TOP2A) in liquid-based cytology (LBC) to identify HSIL. Methodology Observational prospective study including 250 patients referred to colposcopy. Patients underwent Pap-test, HR-HPV testing, colposcopy, and at least one biopsy. CDKN2A, MKi67 and TOP2A mRNA was detected in LBC specimens by reverse transcription and quantitative polymerase chain reaction. Among HR-HPV positive patients, 49 showed negative pathological findings, 38 harboured low-grade squamous intraepithelial lesions (LSIL), 105 harboured HSIL, and 17 showed discordant results between cytology (HSIL) and biopsy (LSIL). Thirty-five patients were HR-HPV negative and presented negative biopsies (control group). mRNA expression was quantified using ΔCycle threshold and compared between groups. We performed ROC analysis and computed sensitivity and specificity of mRNA expression for HSIL detection. Results Two hundred and forty-three (97.2%) LBC samples yielded adequate material for mRNA determination. We found higher expression of the three biomarkers in HSIL group compared to control group (p<0.05). TOP2A expression was higher in HSIL group compared with women with positive HR-HPV testing and negative biopsy (p<0.05). Patients with discordant results between cytology and biopsy, showed higher expression of all biomarkers compared with the control group (p<0.05). Table 1 shows area under the curve (AUC), sensitivity and specificity of the biomarkers for HSIL detection, at the optimal cut-off point according to ROC curve. Abstract – Table 1 Area under the curve (AUC), sensitivity and specificity of CKN2A, MKi67 and TOP2A for HSIL detection AUC (95% CI) Cut-off point (ΔCycle threshold) Sensitivity (95% CI) Specificity (95% CI) CDKN2A 0.72 (0.61–0.83) -1.04 59.8% (48.9–69.7) 80.0% (62.7–90.5) MKi67 0.74 (0.64–0.84) 3.43 64.5% (54.4–73.5) 76.7% (59.1- 88.2) TOP2A 0.72 (0.62–0.81) 3.55 72.0% (62.2–80.1) 66.7% (48.8–80.8) Conclusion Detection of mRNA of CKN2A, MKi67 and TOP2A in LBC samples showed higher sensitivity than Pap-test to identify women with HSIL. Further studies are needed to confirm that host-cell mRNA detection might have a role in secondary prevention of cervical cancer. Disclosure Nothing to disclose.
When does compassion fatigue hit social workers? Caring for oncology patients in Korea

Understanding compassion fatigue is vital to supporting the health and well-being of oncology psychosocial service providers and oncology patients. This study aims to examine when compassion fatigue is experienced and how it is dealt with by medical social workers providing psychosocial care for oncology patients. A purposeful sample of 12 medical social workers was recruited; each participant was working at a hospital and providing psychosocial care for oncology patients in Korea. Through in-depth qualitative interviews, the following themes emerged regarding oncology social workers’ experiences with compassion fatigue: (1) when compassion fatigue hits me (when bonding with clients, when facing a client’s death, when facing organizational hurdles, when feeling inadequate) and (2) how I deal with compassion fatigue (communicating with others, setting professional boundaries, finding ways to help myself, creating grief rituals, building professional identity). Implications and psychosocial interventions that may help reduce oncology social workers’ compassion fatigue are discussed.
Auditing and Re-auditing Nursing Care for Children Undergoing Central Venous Line Insertion in Pediatric Intensive Care Unit

Aim: The aim was to audit and re-audit nursing care for children undergoing central venous line insertion in Pediatric Intensive Care Unit. Design: A quasi-experimental research design was used for the present study. Setting: The study was carried out at Pediatric Intensive Care Unit, Assiut University Children Hospital. Subjects: Convenience sample was obtained from nurses who gave care to all cases undergoing CVC insertion, working at the previous setting (n= 33). Data Collection Tools: Two tools were used: A structured interview questionnaire sheet and an indirect observation checklist. Results: The study revealed that a mild statistically significance differences were detected as regards CVC Insertion and medication administration (p=0.373 and 0.073 respectively), while the nurses' unsatisfactory practice concerning heparanization and dressing change declined during the re-auditing (p=0.208 and 0.422 respectively). Conclusion: Re-auditing of nurses caring for children undergoing central venous line insertion improved more significantly than auditing. Recommendations: Pediatric nurses should update their knowledge and practice through continued nursing education, training, and frequently attending seminars and conferences especially in infection control skills.
PENINGKATAN KUALITAS HARD SKILL DAN SOFT SKILL MELALUI PENGEMBANGAN PROGRAM TEACHING FACTORY (TEFA) DI SMK MODEL PGRI 1 MEJAYAN

This study aims to analyze the application of teaching factory program (TEFA) in improving the quality of hard skills and soft skills. This research uses descriptive qualitative research methods. This research was conducted with supported interview and documentation methods related to the teaching factory program (TEFA) at SMK Model 1 Mejayan PGRI in 2018/2019 Academic Year. The results of the study stated that there was an increase in hard skills and soft skills needed through character building, the potential of student or teacher HR, interactions between teachers and students, students and students, students and parents, self-control, and business spirit.Keywords: hard skill , soft skill, Teaching Factory (TEFA)
Posaconazole vs Standard Azole (FLU/ITRA) Therapy for Prophylaxis of Invasive Fungal Infections (IFIs) among High-Risk Neutropenic Patients: Results of a Randomized, Multicenter Trial.

Background: Patients with severe and prolonged neutropenia are at high-risk of developing life-threatening IFIs. Despite current treatment option, IFIs are difficult to treat and frequently associated with high mortality rates. Antifungal prophylaxis has shown benefits in high-risk populations and is a standard practice in many institutions. We compared Posaconazole (POS), a new broad-spectrum triazole, vs Standard Azoles for the prevention of IFIs in patients with a new diagnosis or first relapse of acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS) being treated with intensive chemotherapy. Methods: Patients in this randomized, evaluator-blinded, active controlled, multi-center study received oral POS (200mg tid) or oral Standard Azoles (either Fluconazole [FLU 400mg qd] or Itraconazole solution [ITRA 200mg bid]) with each cycle of chemotherapy until complete remission or for up to a maximum of 12 weeks. The primary efficacy end point was the comparison of the incidence of IFIs during the treatment phase (7 days after last dose) as adjudicated by the blinded expert panel based on EORTC/MSG criteria. The incidence of IFIs 100 days after randomization and the clinical outcome at the end of the treatment phase were also compared. Treatment failure was defined as presence of proven or probable IFIs, use of >3 days of empirical systemic antifungal treatment, use of >3 consecutive days or a total of 10 or more days of IV study drug (or alternative formulation for POS), discontinuation due to an adverse event related to study drug or lost to follow-up during treatment. Results: 602 patients were enrolled (304 POS, 298 Standard Azole [240 FLU, 58 ITRA]). The incidence of proven/probable IFIs was lower with POS prophylaxis (see table). The overall mortality was 49 (16%) vs 67 (22%) for patients in the POS and Standard Azoles arms respectively. Analysis of time to death (all cause mortality) within 100 days post randomization yielded a P-value of 0.035, indicating a significant survival benefit in favor of POS. Twenty-one (21) deaths due to IFIs occurred during the study (POS 5, Standard Azoles 16, P = 0.012). Treatment failures were fewer in the POS arm vs Standard Azoles arm (36% vs 46%, P = 0.0091). Safety and tolerability were comparable. Conclusions: In this study, POS was superior to the use of a Standard Azoles (FLU or ITRA) in preventing IFIs and in preventing aspergillosis, in high-risk neutropenic patients with AML or MDS undergoing intensive chemotherapy. Patients receiving POS experienced a significant survival benefit.
Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis: A multicentre study of 1117 cases

Background Diabetes mellitus is a common complication of chronic pancreatitis. It is traditionally considered to develop as a consequence of beta cell loss, but there might be additional factors. Recent studies have highlighted the importance of type 2 diabetes-related risk factors in this context and population-based studies show increased risk of diabetes following acute pancreatitis. The aim of this study was to explore multiple risk factors for diabetes in patients with chronic pancreatitis. Methods We conducted a multicentre, cross-sectional study of patients with definitive chronic pancreatitis according to the M-ANNHEIM criteria. We used multivariable logistic regression models to determine risk factors independently associated with diabetes. Results The study included 1117 patients of whom 457 (40.9 %) had diabetes. The mean age was 52.8 ± 14.2 years and 67% were men. On multivariate analysis, parameters indicative of beta cell loss (pancreatic calcification, exocrine insufficiency, pancreatic resection) were confirmed as independent risk factors for diabetes (all p ≤ 0.02). In addition, type 2 diabetes-related risk factors (dyslipidaemia and overweight/obesity) were associated with the presence of diabetes (all p ≤ 0.002). Patients with a history of pancreatic fluid collections (indicative of previous attacks of acute pancreatitis) had a marginally increased risk of diabetes (p = 0.07). Conclusion In patients with chronic pancreatitis the presence of diabetes is associated with multiple risk factors including type 2 diabetes-related factors. Our observations attest to the understanding of this entity and may have implications for treatment.
Higher efficiency of frozen embryo transfer in male infertility cases in in vitro fertilization.

OBJECTIVE The aim of the present study was to analyze the success rates of frozen and fresh embryo transfer methods in different patient groups. MATERIAL AND METHODS The study included 453 patients who underwent in vitro fertilization (IVF) treatment. The patients were further divided into three groups as male factor, tubal/ovarian/uterine factor, and other factors. IVF treatment was performed through either fresh or frozen embryo transfer (FET). Of the 453 patients, 298 had fresh embryo transfer, and 155 received FET. The implantation and live-birth rates of FET were compared with fresh transfer approach, focusing on the effects of male infertility. RESULTS There was a significant difference between the pregnancy ratios of patients who underwent fresh embryo transfer versus patients who underwent FET. In patients who were receiving IVF treatment due to male factors, the pregnancy rate was 49.32% in the fresh embryo transfer group, whereas it was 69.70% in the FET group, revealing a significant difference between the two groups (p=0.0321). Although the live-birth ratios were higher in the FET group both among all patients who underwent IVF due to male factor, the differences between the groups were not statistically significant. CONCLUSION We observed higher pregnancy rates in FET patients compared with fresh embryo transfer in the study group. The differences in pregnancy rates and live-birth rates were especially evident in IVF cases where male factor was the reason for the treatment.
Association between Clinical Manifestations of Systemic Sclerosis and Esophageal Dysmotility Assessed by High-Resolution Manometry

Purpose To characterize esophageal involvement according to high-resolution manometry (HRM) findings using the 3rd version of the Chicago Classification, in a French population of patients fulfilling the ACR/EULAR 2013 classification criteria for systemic sclerosis (SSc). Methods Thirty-six patients were consecutively included in this cross-sectional non-interventional study and had HRM performed in Rennes University hospital. Demographic and clinical characteristics, SSc history and interstitial lung disease (ILD) on CT-scan were assessed, and compared with esophageal motility. Results Sixty-one percent of SSc patients had ineffective peristalsis (55.6% failed peristalsis and 5.6% weak peristalsis), 33.3% had hypotensive esophagogastric junction pressure, 75% did not have a physiologic contraction following multiple rapid swallow (MRS), and 44.4% had an abnormal peristaltic reserve. One patient had type 1 achalasia and another one had Jackhammer esophagus. Failed peristalsis was associated with pyrosis (odds ratio [OR] 7.28, 95% confidence interval [CI] 1.51-35.21, p = 0.009), a higher modified Rodnan skin score (MRSS) (without failed peristalsis: 4.68 ± 2.95 vs. with failed peristalsis: 10.68 ± 9.23; p<0.05), the presence of telangiectasia (OR 7, 95% CI 1.59-30.8, p = 0.007), and low diffusing capacity of the lung for carbon monoxide (DLCO) (p = 0.013). Food in the esophagus and esophageal dilation on CT-scan were associated with failed contractions on HRM (respectively, OR 6.85, 95% CI 1.12-40.82, p = 0.05, and OR 14.67, CI 2.4-88.5, p = 0.002). Conclusions This study confirms that failed peristalsis is frequent in SSc and associated with other organ involvement. We found a concordance between HRM results and CT-scan findings regarding esophageal involvement.
Health promotion behaviors and its correlation with some of the demographic factors in patients with multiple sclerosis

AbstractBackground and Aim:The health promotion behaviors are effective factors in prevention of diseases. The aim of this studywas to determine, the health promotion behaviors and their relationship with demographic factors inpeople with multiple sclerosis.Materials and Methods:This study was a descriptive cross-sectional survey assessing health-promoting behaviors amongpatients with multiple sclerosis. 51 patients with multiple sclerosis referred to MS clinic of Al-Zahra Hospital were randomly selected. The health-promoting behaviors were measured usingHPLP-II (Health Promotion Lifestyle profile-II) and Expanded Disability Status Scale (EDSS). Data were analyzed by independent t-test, Pearson Correlation, Spearman correlation and One-WayANOVA.Findings:The overall health-promoting behaviors' profile had a mean ± SD of 119.6±12. The highest mean inthe sub-scales was for “spiritual growth” (22.8±3/8) and the lowest was for “physical activity”(15.3±3.52). The results indicated that there was not a significant difference between two genders.Pearson's correlation indicated a negative relationship between Expanded Disability Status Scalewith mean of overall health-promoting behaviors' profile. There were also significant correlationsbetween the levels of education with mean of overall health-promoting behaviors' profile.Conclusion:Regarding the situation of health-promoting behaviors, especially in physical activity sub-scale,providing programs to improve health promotion behaviors in people with multiple sclerosis arerecommended.Keywords:Health Behavior; Multiple sclerosis; Demographic Factors
Nurses' knowledge of heart failure in a North Carolina community hospital

Heart failure (HF) is an epidemic affecting approximately 5.1 million people in the United States and is one of the most expensive cardiovascular illnesses, costing the nation an estimated $32 billion each year (CDC, 2013). There is no cure for HF, but following guidelines established by the American Heart Association can contribute to decreased mortality, improved quality of life, and decreased hospital admissions. Nurses play an essential role in providing comprehensive HF self-management education to patients, and thus, should be knowledgeable about HF principles themselves. Research suggests that nurses may not have adequate knowledge of HF management to educate patients, and consequently, are not optimally prepared to provide HF education (Hart, Spiva, & Kimble, 2011). This was an exploratory, descriptive study with a survey design seeking to describe nurses’ knowledge of HF self-management principles within a community hospital in North Carolina. The Nurses’ Knowledge of Heart Failure Education Principle questionnaire developed by Dr. Nancy Albert (2002) was utilized to determine which HF education topics nurses were knowledgeable about and which topics they were deficient. Thirty-two registered nurses agreed to participate, with a mean knowledge score of 15.75 (78.75% correct). Consistent with previous studies, nurses scored lowest on knowledge related to transient dizziness (28.1% correct), asymptomatic hypotension (18.8% correct), daily weight assessment (25% correct), and salt substitutes (53.1% correct). Findings confirm previous work suggesting that nurses may not be adequately prepared to educate patients with HF about self-management.This aspect of nursing education is important, because nurses caring for HF patients need to have sufficient knowledge of HF self-management principles in order to provide optimal education to patients. Lack of adequate education for HF patients results in noncompliance with outpatient treatment modalities and ultimately leads to hospital readmissions related to HF exacerbation. Nurses with adequate knowledge of HF can provide better education to patients on how to manage their HF, potentially reducing hospital readmission rates related to HF and improving patients’ overall quality of health.
Gerontolizing Nephrology: Spectrum of Histopathological Findings of Kidney Biopsy in the Elderly

Introduction: The spectrum of renal disorder in the elderly differs from the younger population. There is a paucity of literature regarding kidney biopsy in elderly. This study aims to highlight the clinical profile and histopathological spectrum of the elderly patient undergoing a renal biopsy. Materials and Methods: This retrospective study included all patients (age ≥60 years) undergoing native renal biopsies from January 2012 to December 2017. The clinical profile, laboratory parameters, and renal biopsy findings of these patients were recorded from the case files. Results: Out of 1656 renal biopsies performed during the study period, 230 (13.9%%) performed on the elderly were included. Mean age was 64.02 ± 7.87 years (Range: 60-87 years), and males were predominant (70.4%). The commonest indication for biopsy was nephrotic syndrome (NS) (49.6%) followed by Rapidly progressive renal failure (RPRF) (20.9%) and Acute Kidney Injury (AKI) (15.7%). The most frequent histological diagnosis was membranous nephropathy (15.2%) followed by amyloidosis (13.9%) and Focal Segmental Glomerulosclerosis (FSGS) (13.0%). The commonest cause of NS was MGN (29.8%) followed by FSGS (24.6%) and amyloidosis (22.8%). The commonest cause of nephritic syndrome was Diffuse Proliferative Glomerulonephritis (29.4%) and Membranoproliferative Glomerulonephritis (29.4%). Hypertensive nephrosclerosis (40.0%) and diabetic nephropathy (26.7%)) were the commonest histological diagnosis in the patients who underwent renal biopsy for clinical Chronic kidney disease. Crescentic GN (35.4%) and Myeloma cast nephropathy 14.6%) were the commonest cause of RPRF while Acute Tubular Necrosis (41.7%) was the commonest cause of AKI. None of the patients had major complications. Conclusion: Renal biopsy is safe in the elderly and provides a wealth of information with regards to the diagnosis and prognosis of renal disorder.
Deciding online and offline sales strategies when service industry customers express fairness concerns

ABSTRACT In recent years the range of channels for customers to acquire products has generally expanded. The Smart-X system plays an essential role in pricing strategies, as fairness concerns could impact the price significantly. When customers in the BM store have concerns, the firm is induced to lower product price in the store, resulting in total profit reduction. When customers do not have fairness concerns, it is always better for the firm to operate in dual channels. Additionally, we demonstrate that a range of service cost coefficients exist, and, within certain ranges, these may inhibit the firm from upgrading service levels.
An IoT Integrated Tool to Enhance User Awareness on Energy Consumption in Residential Buildings

Unaware behaviors of occupants can affect energy consumption even more than incorrect installations and building envelope inefficiencies, with significant overconsumptions widely documented. Real time data and an effective and frequent billing of actual consumptions are required to reach an adequate awareness of energy consumption. From this point of view, the European Directive 2012/27/EU already imposed the use of metering and sub-metering systems, setting the minimum criteria for billing and related information based on real energy consumption data. To assess the ability of buildings to exploit new information and communication technologies (ICT) and sensitize both landlords and tenants to related savings, the new European Directive 2018/844/EU promotes the use of a smart readiness indicator. At the same time, basic information about indoor thermal comfort should be also gathered, aimed at avoiding that an excessive saving tendency can determine the onset of issues related to excessively low internal temperatures. In this paper, the authors address the problem of gathering, processing, and transmitting energy consumption and basic indoor air temperature data in the framework of an Internet of Things (IoT) integrated tool aimed at increasing residential user awareness through the use of consumption and benchmark indexes. Two case-studies in which thermal and electrical energy monitoring systems have been tested are presented and discussed. Finally, the suitability of the communication of energy consumption in terms of temporal, spatial, and typological aggregation has been evaluated.