Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of mixed meal ingestion on fuel utilization in the whole body and in superficial and deep forearm tissues

Six healthy lean male adults, given a mixed meal containing 3190 kJ (16% from protein, 44% from carbohydrate and 40% from fat) were studied for the next 370 min using arteriovenous cannulation techniques across superficial and deep forearm tissues. The meal produced no significant change in forearm blood flow or skin temperature. The major differences between superficial and deep forearm tissues were (a) creatinine release by deep tissues but not superficial tissues; (b) the release of non-esterified fatty acids (NEFA) by superficial tissues and uptake by deep tissues; and (c) the more prolonged large positive arteriovenous concentration difference for glucose across deep than superficial tissues. The similarities were (a) general pattern of individual amino acid exchanges and transient positive amino acid N balance after meal ingestion; (b) consistent uptake of glutamate and release of glutamine (the main carrier of N out of superficial and deep forearm tissues); (c) the magnitude of the arteriovenous concentration differences for glucose, NEFA and total amino acids were related to the changes in their circulating concentrations and to the oxidation of carbohydrate, fat, and protein in the whole body; and (d) increases in the arterio–deep venous and arterio–superficial venous differences for glucose did not result in increased release of lactate, alanine or pyruvate, implying no increase in the activity of glucose–lactate and glucose–alanine cycles between forearm tissues and the liver. This study suggests that in a number of ways superficial and deep tissues can be regarded, at least qualitatively, as behaving as a ‘single metabolic unit’.
A model of neuronal bursting using three coupled first order differential equations

We describe a modification to our recent model of the action potential which introduces two additional equilibrium points. By using stability analysis we show that one of these equilibrium points is a saddle point from which there are two separatrices which divide the phase plane into two regions. In one region all phase paths approach a limit cycle and in the other all phase paths approach a stable equilibrium point. A consequence of this is that a short depolarizing current pulse will change an initially silent model neuron into one that fires repetitively. Addition of a third equation limits this firing to either an isolated burst or a depolarizing afterpotential. When steady depolarizing current was applied to this model it resulted in periodic bursting. The equations, which were initially developed to explain isolated triggered bursts, therefore provide one of the simplest models of the more general phenomenon of oscillatory burst discharge.
Adaptive Fuzzy Backstepping Tracking Control for Strict-Feedback Systems With Input Delay

This paper investigates the problem of adaptive fuzzy tracking control for nonlinear strict-feedback systems with input delay and output constraint. Input delay is handled based on the information of Pade approximation and output constraint problem is solved by barrier Lypaunov function. Some adaptive parameters of the controller need to be updated online through considering the norm of membership function vector instead of all sub-vectors. A novel adaptive fuzzy tracking control scheme is developed to guarantee all variables of the closed-loop systems are semiglobally uniformly ultimately bounded, and the tracking error can be adjusted around the origin with a small neighborhood. The stability of the closed-loop systems is proved and simulation results are given to demonstrate the effectiveness of the proposed control approach.
Violent behaviour among people with schizophrenia: a framework for investigations of causes, and effective treatment, and prevention

Robust evidence has accumulated showing that individuals who develop schizophrenia are at elevated risk when compared to the general population to engage in violence towards others. This violence impacts negatively on victims as well as perpetrators and poses a significant financial burden to society. It is posited that among violent offenders with schizophrenia there are three distinct types defined by the age of onset of antisocial and violent behaviour. The early starters display a pattern of antisocial behaviour that emerges in childhood or early adolescence, well before illness onset, and that remains stable across the lifespan. The largest group of violent offenders with schizophrenia show no antisocial behaviour prior to the onset of the illness and then repeatedly engage in aggressive behaviour towards others. A small group of individuals who display a chronic course of schizophrenia show no aggressive behaviour for one or two decades after illness onset and then engage in serious violence, often killing, those who care for them. We hypothesize that both the developmental processes and the proximal factors, such as symptoms of psychosis and drug misuse, associated with violent behaviour differ for the three types of offenders with schizophrenia, as do their needs for treatment.
Meta-Heuristic Approach for Resource Optimization in Mobile Real Time Video Traffic

With the advent of Next generation wireless networks such as 4G, thousands of users will be able to share, create and access live video streaming with different content and characteristics, such as cricket matches and video surveillance using handheld mobile devices. Such services demand new mechanisms for assessing the quality levels of videos. It is imperative for the network operator to exercise stringent control over network parameters and deliver real time video with uncompromising quality in spite of hostile mobile environment. In this paper, Simulated Annealing is used as one of the meta-Heuristic approach for resource optimization in mobile real time video traffic. Other meta-heuristic methods such as Tabu search and genetic algorithms were used in the past. It is found that tabu search gets trapped in local minimum and genetic algorithms are computationally intensive. In this direction, simulated annealing has been found to exhibit effective global minimization with reduced number of iterations. Improvement in performance has been depicted through function plots such as Best function value, Best point, stopping criteria and temperature plot. The algorithm has been tested on standard video quality database available on university at Texas portal. General Terms Meta Heuristic, Optimization.
The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: a randomized controlled trial of insulin infusion therapy for myocardial infarction.

OBJECTIVE There is conflicting evidence regarding the benefit of intravenous insulin therapy on mortality following acute myocardial infarction (AMI). The goal of the current study was to determine whether improved glycemic control, achieved through an insulin/dextrose infusion with a variable rate of insulin, reduces mortality among hyperglycemic patients with AMI. RESEARCH DESIGN AND METHODS Subjects suffering AMI with either known diabetes or without diabetes but blood glucose level (BGL) > or =7.8 mmol/l were randomized to receive insulin/dextrose infusion therapy for at least 24 h to maintain a BGL <10 mmol/l or conventional therapy. RESULTS A total of 240 subjects were recruited. Insulin/dextrose infusion did not reduce mortality at the inpatient stage (4.8 vs. conventional 3.5%, P = 0.75), 3 months (7.1 vs 4.4%, P = 0.42), or 6 months (7.9 vs. 6.1%, P = 0.62). There was, however, a lower incidence of cardiac failure (12.7 vs. 22.8%, P = 0.04) and reinfarction within 3 months (2.4 vs. 6.1%, P = 0.05). When analyzed by mean BGL achieved during the first 24 h, mortality was lower among subjects with a mean BGL < or =8 mmol/l, compared with subjects with a mean BGL >8 mmol/l (2 vs. 11% at 6 months, P = 0.02). CONCLUSIONS We did not find a reduction in mortality among patients who received insulin/dextrose infusion therapy. However, it remains possible that tight glycemic control with insulin therapy following AMI improves outcomes.
Corrective mechanisms of motion extrapolation

Transmission and processing of sensory information in the visual system takes time. For motion perception, our brain can overcome this intrinsic neural delay through extrapolation mechanisms and accurately predict the current position of a continuously moving object. But how does the system behave when the motion abruptly changes and the prediction becomes wrong? Here we address this question by studying the perceived position of a moving object with various abrupt motion changes by human observers. We developed a task in which a bar is monotonously moving horizontally, and then motion suddenly stops, reverses, or disappears-then-reverses around two vertical stationary reference lines. Our results showed that participants overestimated the position of the stopping bar but did not perceive an overshoot in the motion reversal condition. When a temporal gap was added at the reverse point, the perceptual overshoot of the end point scaled with the gap durations. Our model suggests that the overestimation of the object position when it disappears is not linear as a function of its speeds but gradually fades out. These results can thus be reconciled in a single process where there is an interplay of the cortical motion prediction mechanisms and the late sensory transient visual inputs.
Accuracy of Admissible Heuristic Functions in Selected Planning Domains

The efficiency of optimal planning algorithms based on heuristic search crucially depends on the accuracy of the heuristic function used to guide the search. Often, we are interested in domain-independent heuristics for planning. In order to assess the limitations of domain-independent heuristic planning, we analyze the (in)accuracy of common domain-independent planning heuristics in the IPC benchmark domains. For a selection of these domains, we analytically investigate the accuracy of the h+ heuristic, the hm family of heuristics, and certain (additive) pattern database heuristics, compared to the perfect heuristic h*. Whereas h+and additive pattern database heuristics usually return cost estimates proportional to the true cost, non-additive hm and nonadditive pattern-database heuristics can yield results underestimating the true cost by arbitrarily large factors.
Increased Sensitivity to CD4 Binding Site-Directed Neutralization following In Vitro Propagation on Primary Lymphocytes of a Neutralization-Resistant Human Immunodeficiency Virus IIIB Strain Isolated from an Accidentally Infected Laboratory Worker

ABSTRACT We previously described the adaptation of the neutralization-sensitive human immunodeficiency virus type 1 (HIV-1) strain IIIB to a neutralization-resistant phenotype in an accidentally infected laboratory worker. During long-term propagation of this resistant isolate, designated FF3346, on primary peripheral blood leukocytes in vitro, an HIV-1 variant appeared that had regained sensitivity to neutralization by soluble CD4 (sCD4) and the broadly neutralizing monoclonal antibody b12. When an early passage of FF3346 was subjected to limiting-dilution culture in peripheral blood mononuclear cells, eight virus variants with various degrees of neutralization resistance were isolated. Two of them, the sCD4 neutralization-resistant variant LW_H8res and the sCD4 neutralization-sensitive variant LW_G9sens, were selected for further study. Interestingly, these two viruses were equally resistant to neutralization by agents that recognize domains other than the CD4 binding site. Site-directed mutagenesis revealed that the increased neutralization sensitivity of variant LW_G9sens resulted from only two changes, an Asn-to-Ser substitution at position 164 in the V2 loop and an Ala-to-Glu substitution at position 370 in the C3 domain of gp120. In agreement with this notion, the affinity of b12 for monomeric gp120 containing the N164S and A370E substitutions in the background of the molecular clone LW_H8res was higher than its affinity for the parental gp120. Surprisingly, no correlation was observed between CD4 binding affinity for monomeric gp120 and the level of neutralization resistance, suggesting that differences in sCD4 neutralization sensitivity between these viruses are only manifested in the context of the tertiary or quaternary structure of gp120 on the viral surface. The results obtained here indicate that the neutralization-sensitive strain IIIB can become neutralization resistant in vivo under selective pressure by neutralizing antibodies but that this resistance may be easily reversed in the absence of immunological pressure.
Adaptive, Network-Aware Cluster Selection for Cloud Computing in Wireless Networks

We describe and demonstrate fully distributed algorithms that enable cloud clients to select among a set of available computing clusters adaptively, based on measurements of cluster computing loads and the relative bandwidths of paths between the client and each cluster. These techniques are particularly important in cases where (1) clients connect to clusters over stressed wireless networks whose characteristics vary considerably over time, and (2) cloud computing resources are physically dispersed over several locations to improve robustness against physical attack, power failure, network failure, or cyber attack. We demonstrate new means of measuring path bandwidth reliably over multi-hop wireless networks. We then show how the resulting network awareness can be combined with available data on cluster computing loads to arrive at favorable cluster selection decisions by cloud clients, without the need for a centralized cloud controller.
Generating a Gaussian sample

The general theoretical difficulties in analyzing the effect of a random input signal on a known system are pointed out. Basically, if certain output statistics are computed directly, each statistic represents a complete, separate problem. An alternative analytical computational procedure is suggested, using a Monte Carlo type technique in which the output is obtained by numerical integration from sequences of values which represent members of the statistical ensemble of the input process. For such applications, or for other possible uses such as in testing, it is necessary to generate statistical sequences, analogous to tables of random numbers. Techniques are discussed for analytically generating such sequences, to correspond to gaussian probability distributions which are further characterized by arbitrarily specified power spectra or autocorrelation functions. The procedure makes use of the standard tables of random numbers, these numbers being distributed uniformly and without correlation. The exact statistical generation of N values of a sequence is shown to require, in general, the diagonalization (or solution for the eigenvalues and eigenvectors) of an N th order matrix; two simpler approximate procedures are also described.
Polar bears: proceedings of the 15th Working Meeting of the IUCN/SSC Polar Bear Specialist Group, Copenhagen, Denmark, 29 June3 July 2009

These 15th Proceedings provide an overview of the ongoing research and management activities on polar bears in the circumpolar Arctic. Together with the previous 14 proceedings, they provide an historic record of the international effort in protecting, studying, and managing polar bears. The document addresses more recent concerns of threats arising as a consequence of increased human activities in both the Arctic and in regions far beyond the Arctic. Previous proceedings included a Status Report for each of the worlds subpopulations, which focused largely on the known or unknown status as it related to harvest. In the Status Report of the 15th Proceedings, we provide a more comprehensive assessment of all threats to the status of each polar bear subpopulation.
A Bimodal Face and Body Gesture Database for Automatic Analysis of Human Nonverbal Affective Behavior

To be able to develop and test robust affective multimodal systems, researchers need access to novel databases containing representative samples of human multi-modal expressive behavior. The creation of such databases requires a major effort in the definition of representative behaviors, the choice of expressive modalities, and the collection and labeling of large amount of data. At present, public databases only exist for single expressive modalities such as facial expression analysis. There also exist a number of gesture databases of static and dynamic hand postures and dynamic hand gestures. However, there is not a readily available database combining affective face and body information in a genuine bimodal manner. Accordingly, in this paper, we present a bimodal database recorded by two high-resolution cameras simultaneously for use in automatic analysis of human nonverbal affective behavior
Untyped Memory in the Java Virtual Machine

We have implemented a virtual execution environment that executes legacy binary code on top of the type-safe Java Virtual Machine by recompiling native code instructions to type-safe bytecode. As it is essentially impossible to infer static typing into untyped machine code, our system emulates untyped memory on top of Java’s type system. While this approach allows to execute native code on any off-the-shelf JVM, the resulting runtime performance is poor. We propose a set of virtual machine extensions that add type-unsafe memory objects to JVM. We contend that these JVM extensions do not relax Java’s type system as the same functionality can be achieved in pure Java, albeit much less efficiently. 1 Executing Native Machine Code on top of JVM Our research prototype VEELS (Virtual Execution Environment for Legacy Software) is able to execute statically compiled Linux [2] executables for PowerPC, StrongARM, and MIPS on top of any standard Java Virtual Machine [4]. All native code and data is stored within a memory object that emulates untyped memory. A virtual CPU fetches instructions from the memory object and interprets them. Frequently executed code blocks are translated to bytecode by a just-in-time compiler to allow more efficient execution Figure 1. 2 Emulating Untyped Memory The standard implementation of the memory object in VEELS uses a sparse integer array as backing store. Each 4k page of the guest machine is modeled as an array of integers, referenced by a page table. The most common access patterns—reading and writing words from and to memory at an aligned address—are handled efficiently with two memory accesses and a pair of array bounds checks.
Evolution of the Cluster X-Ray Luminosity Function

We report measurements of the cluster X-ray luminosity function out to z = 0.8 based on the final sample of 201 galaxy systems from the 160 Square Degree ROSAT Cluster Survey. There is little evidence for any measurable change in cluster abundance out to z ~ 0.6 at luminosities of less than a few times 1044 h ergs s-1 (0.5-2.0 keV). However, for 0.6 < z < 0.8 and at luminosities above 1044 h ergs s-1, the observed volume densities are significantly lower than those of the present-day population. We quantify this cluster deficit using integrated number counts and a maximum likelihood analysis of the observed luminosity-redshift distribution fit with a model luminosity function. The negative evolution signal is more than 3 σ regardless of the adopted local luminosity function or cosmological framework. Our results and those from several other surveys independently confirm the presence of evolution. Whereas the bulk of the cluster population does not evolve, the most luminous and presumably most massive structures evolve appreciably between z = 0.8 and the present. Interpreted in the context of hierarchical structure formation, we are probing sufficiently large mass aggregations at sufficiently early times in cosmological history, when the universe has yet to assemble these clusters to present-day volume densities.
Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study

Background: Transient elastography (FibroScan) is a new, non-invasive, rapid, and reproducible method allowing evaluation of liver fibrosis by measurement of liver stiffness. In cirrhotic patients, liver stiffness measurements range from 12.5 to 75.5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease. Methods: A total of 711 patients with chronic liver disease were studied. Aetiologies of chronic liver diseases were hepatitis C virus or hepatitis B virus infection, alcohol, non-alcoholic steatohepatitis, other, or a combination of the above aetiologies. Liver fibrosis was evaluated according to the METAVIR score. Results: Stiffness was significantly correlated with fibrosis stage (r = 0.73, p<0.0001). Areas under the receiver operating characteristic curve (95% confidence interval) were 0.80 (0.75–0.84) for patients with significant fibrosis (F>2), 0.90 (0.86–0.93) for patients with severe fibrosis (F3), and 0.96 (0.94–0.98) for patients with cirrhosis. Using a cut off value of 17.6 kPa, patients with cirrhosis were detected with a positive predictive value and a negative predictive value (NPV) of 90%. Liver stiffness was significantly correlated with clinical, biological, and morphological parameters of liver disease. With an NPV >90%, the cut off values for the presence of oesophageal varices stage 2/3, cirrhosis Child-Pugh B or C, past history of ascites, hepatocellular carcinoma, and oesophageal bleeding were 27.5, 37.5, 49.1, 53.7, and 62.7 kPa, respectively. Conclusion: Transient elastography is a promising non-invasive method for detection of cirrhosis in patients with chronic liver disease. Its use for the follow up and management of these patients could be of great interest and should be evaluated further.
The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders

Aggressive symptomatology presents across multiple psychiatric, developmental, neurological and behavioral disorders, complicating the diagnosis and treatment of the underlying pathology. Anti-Epileptic Drugs (AEDs) have become an appealing alternative in the treatment of aggression, mood lability and impulsivity in adult and pediatric populations, although few controlled trials have explored their efficacy in treating pediatric populations. This review of the literature synthesizes the available data on ten AEDs—valproate, carbamazepine, oxcarbazepine, phenytoin, lamotrigine, topiramate, levetiracetam, zonisamide, gabapentin and tiagabine—in an attempt to assess evidence for the efficacy of AEDs in the treatment of aggression in pediatric populations. Our review revealed modest evidence that some of the AEDs produced improvement in pediatric aggression, but controlled trials in pediatric bipolar disorder have not been promising. Valproate is the best supported AED for aggression and should be considered as a first line of treatment. When monotherapy is insufficient, combining an AED with either lithium or an atypical anti-psychotic can result in better efficacy. Additionally, our review indicates that medications with predominately GABA-ergic mechanisms of action are not effective in treating aggression, and medications which decrease glutaminergic transmission tended to have more cognitive adverse effects. Agents with multiple mechanisms of action may be more effective.
Description of the Oki System as Used for MUC-7

This paper describes the Oki Information Extraction system as used for MUC-7 evaluation [1][2]. The tasks we have conducted are Named Entity, Co-reference, Template Element and Template Relation. Each module is implemented using MT system modules and pattern recognition modules. Our purposes to participate MUC-7 evaluation are to evaluate howMT system modules are e ective for other application such as IE system and to develop our information extraction technology based on pattern recognition.