Miracle-dz/UniFAR-FTUs huggingface dataset:
APOE/C1/C4/C2 Gene Cluster Genotypes, Haplotypes and Lipid Levels in Prospective Coronary Heart Disease Risk Among UK Healthy Men

The role of common APOE variants on plasma lipids, particularly low density lipoprotein (LDL) levels, and coronary heart disease (CHD) risk is well known; the influence of variation in the other nearby apolipoprotein genes APOC1, APOC4 and APOC2 is unclear. This study examines the association between APOE/C1/C4/C2gene cluster variation using tagging SNPs and plasma lipid concentration along with risk of CHD in a prospective cohort. Genotypes for 11 common APOE/C1/C4/C2SNPs were determined in 2,767 middle-aged (49 to 64 years) men from the Second Northwick Park Heart Study, with 275 CHD events over a 15-year follow-up period. Seven SNPs showed significant associations with one or more lipid trait in univariate analysis. Multivariate and haplotype analysis showed that the APOE genotypes are most strongly associated with effects on LDL-C and apoB concentration (explaining 3.4% of the LDL-C variance) while the other SNPs in this gene cluster explained an additional 1.2%. Haplotypes in APOC2 and APOC4 were associated with modest effects on HDL-C and apoAI (explaining respectively 1.4% and 1.2%). Carriers of the APOE ε2 SNP had a significantly lower risk of CHD hazard ratio (HR) of 0.63 (95% confidence interval (CI): 0.42–0.95), as did carriers of the APOC2 SNP rs5127 (HR = 0.72, 95% CI: 0.56–0.93), while carriers of APOC1 SNP rs4803770 had higher risk of CHD (HR = 1.36, 95% CI: 1.04–1.78) compared with noncarriers. While the common APOE polymorphism explains the majority of the locus genetic determinants of plasma lipid levels, additional SNPs in the APOC1/C2 region may contribute to CHD risk, but these effects require confirmation.
Fluorescein Tri-Aldehyde Promotes the Selective Fluorescein Tri-Aldehyde Promotes the Selective Detection of Homocysteine Detection of Homocysteine

The effects of extraneous surface charges on the anomalous extinction from metallic nanoparticles are studied via an application of the extended Mie theory by Bohren and Hunt. Due to the sensitivity of the higher multipolar resonance on the surface charges, it is found that quenching of the anomalous resonance can be observed with presence of only a modest amount of charges on these particles. The observed effects thus provide a rather sensitive mechanism for the monitoring of the neutrality of these nanoparticles using far ﬁ eld scattering approaches.
Influence of the seismic noise characteristics on noise correlations in the Baltic Shield

SUMMARY It has recently been shown that correlations of seismic noise can contain significant information about the Green's function along the station profile. Using an array of 38 temporary broadband stations located in Finland between September 1998 and March 1999, we study the resulting 703 noise correlations to understand how they are influenced by the directivity of the noise field. The latter information is obtained through f-k analysis of data from two permanent seismic arrays in Germany and Norway and from a subset of stations of the array in Finland. Both types of analysis confirm that the characteristics of the seismic noise is strongly frequency dependent. At low frequencies (0.02-0.04 Hz), we observe diffuse noise and/or randomly distributed sources. In contrast, the noise is strongly direction dependent and not fully diffuse in the intermediate period ranges (0.04-0.25 Hz) which correspond to the first and second microseismic peak, created at the Irish and Scottish coast and the western coast of Norway. In this frequency interval the noise is sufficiently close to a plane wave to introduce systematic errors in group velocities for station pairs which are not parallel to direction of the dominant incident noise. Phase velocities calculated by slant stack over many traces are however correct, independently of profile direction. In the high frequency band (0.25-1.0 Hz), the situation is a mix between the low-frequency and the intermediate frequency cases. Average phase velocities and individual group velocities from well-oriented profiles are in excellent agreement with results from Rayleigh wave studies of the area.
Geochemistry and mineralization age of the Mayuan zinc deposit, Nanzheng, southern Shaanxi, China

The newly discovered Mayuan zinc deposit is located on the north margin of the Yangtze craton.It occurs in an interformational fault zone of dolostone of the Sinian Dengying Formation.Sphalerite is usually associated with solid bitumen.The sphalerite gives an Rb-Sr isochron age of 486 Ma±,showing that the deposit formed in the Caledonian stage.Carbon and oxygen isotope and trace element and REE studies of the minerals indicate that the ore-formation materials of the Zn deposit and fluids mainly originated from host rocks.Integrated analysis shows that this zinc deposit is a stratabound MVT deposit hosted in Sinian carbonate rocks.
A dynamic model of demand for private health insurance in Ireland

Title A dynamic model of demand for private health insurance in Ireland Authors(s) Finn, Claire; Harmon, Colm Publication date 2006-11-23 Series UCD Geary Institute Discussion Paper Series; WP/2006/12 Publisher University College Dublin. Geary Institute Link to online version http://geary.ucd. ie/images/Publications/WorkingPapers/gearywp200612.pdf Item record/more information http://hdl.handle. net/10197/1109
Occam's inversion of 3-D electrical resistivity tomography. Three-dimensional Electromagnetics

Electrical resistivity tomography (ERT) images the electrical properties of the subsurface from dc resistivity measurements between surface and borehole electrodes. We experiment with 3-D inversion of ERT using finite-element forward solution and a conjugate-gradient inverse routine. The algorithm finds the smoothest model (Occam’s inversion) that fits the data to a given prior error level. The algorithm takes 10 to 20 iterations to converge but requires only a single forward solution per iteration and does not require direct solution of a large system of equations. Inversion of data from two sites is shown. The first site tests the ability of ERT to monitor leaks around large metal tanks at the Hanford Reservation in Washington State. Data were collected and inverted from 16 wells placed around a circular tank. The tank is of heavy-gauge steel covered with concrete, is 15 m in diameter, and extends 2 m below the ground surface. The 3-D algorithm was modified to allow the smoothness operator to be decreased at the tank boundary. The 3-D inversion was necessary to produce an accurate picture of the leak. At a second site, ERT was used to monitor the injection of air from a vertical well at a shallow petroleum remediation site. Using a cone penetrometer, three electrode strings were placed in the ground on the corners of a right triangle. The background of the site was assumed to be layered. Results of 3-D and 2-D inversion agreed well when the regions of interest were approximately 2-D. Air injection caused large changes in resistivity. At early times, these were confined to an area near the injection point. Later, the changes were along a dipping, tabular region. At the latest times, there is evidence of mixing of brackish water at the depth of the injection point with freshwater in a shallower aquifer on the site. This mixing would have decreased the resistivity and thus the apparent size and magnitude of the zone of influence of sparging.
LOST CITY METEORITE: DETERMINATION OF THE TEMPERATURE GRADIENT INDUCED BY ATMOSPHERIC FRICTION USING THERMOLUMINESCENCE

The temperature gradient induced in the Lost City meteorite during its nine-second flight through the atmosphere has been determined from measurements of the variations in the natural TL output of the meteorite with depth below the surface of the specimen. The rate of temperature change decreases about 5 °C per mm in the range of 4 mm to 15 mm below its surface. Although temperatures above 205 °C penetrated only the outer 4 mm of the meteorite, temperatures higher than 120 °C penetrated as far as 20 mm below its surface.
Spatio-Temporal Variation in Vertical Distributions of Pacific Salmon in the Ocean

The vertical distribution of Pacific salmon ( Oncorhynchus spp.) is of interest to biologists and the fishing industry. An understanding of the normal vertical distribution and movement of salmon facilitates better manage- ment of both directed and non-salmon fisheries and better evaluation of research data. Salmon vertical distribu - tion can vary spatially in relation to distance from shore, depth of the water column, and by ocean region, and temporally by life-history stage, season, time of day, and ocean conditions. In coastal waters, juvenile salmon were usually less than 15 m from the surface. In offshore waters, salmon were usually within the top 40 to 60 m, above the thermocline, but occasionally were found from 80 to 120 m. They usually were near the surface at night, and moved vertically during the day. Sockeye salmon displayed the shallowest vertical distribution, followed by pink, coho, chum, and Chinook salmon. There are limited data for winter, but vertical distributions may not change substantially from summer in offshore waters, while it may shift in some species in coastal and shelf areas. There is a need for more long-term data, throughout the marine residency of individual fish.
Biij Biomedical Imaging and Intervention Journal Development and Use of Iron Oxide Nanoparticles (part 1): Synthesis of Iron Oxide Nanoparticles for Mri

Contrast agents, such as iron oxide, enhance MR images by altering the relaxation times of tissues in which the agent is present. They can also be used to label targeted molecular imaging probes. Unfortunately, no molecular imaging probe is currently available on the clinical MRI market. A promising platform for MRI contrast agent development is nanotechnology, where superparamagnetic iron oxide nanoparticles (SPIONS) are tailored for MR contrast enhancement, and/or for molecular imaging. SPIONs can be produced using a range of methods and the choice of method will be influenced by the characteristics most important for a particular application. In addition, the ability to attach molecular markers to SPIONS heralds their application in molecular imaging. There are many reviews on SPION synthesis for MRI; however, these tend to be targeted to a chemistry audience. The development of MRI contrast agents attracts experienced researchers from many fields including some researchers with little knowledge of medical imaging or MRI. This situation presents medical radiation practitioners with opportunities for involvement, collaboration or leadership in research depending on their level of commitment and their ability to learn. Medical radiation practitioners already possess a large portion of the understanding, knowledge and skills necessary for involvement in MRI development and molecular imaging. Their expertise in imaging technology, patient care and radiation safety provides them with skills that are directly applicable to research on the development and application of SPIONs and MRI. In this paper we argue that MRI SPIONs, currently limited to major research centres, will have widespread clinical use in the future. We believe that knowledge about this growing area of research provides an opportunity for medical radiation practitioners to enhance their specialised expertise to ensure best practice in a truly multidisciplinary environment. This review outlines how and why SPIONs can be synthesised and examines their characteristics and limitations in the context of MR imaging.
THE HUMAN REMAINS FROM THE BYZANTINE MONASTERY AT KHAN EL-AHMAR

The following report presents the results of research on the skeletal material from the crypt of the Byzantine Khan el-Ahmar monastery in the Judean desert. The anthropological excavation was carried out during the summer of 1988. Previous archaeological excavation of the burial crypt caused sizable damage to the bones. Additional destruction was caused by mud sediment left after flooding, which slowly dried over the bones. Despite our careful excavation and advanced preservation techniques, recovery of intact bones was almost impossible. Our study was thus based on isolated, mostly fragmented bones. The skeletons in the crypt were lying in rows, one on top of the other, along the long axis of the crypt wall. All were primary burials, in a supine position, with no evidence of skull detachment (as often seen in material from other monasteries). The cadavers were not covered with sediment. A few skulls had a large circular postmortem hole either in the occipital or parietal region (Pl. 1:a), an observation made on many other Byzantine skulls (Hershkovitz et al., 1988). This phenomenon apparently occurred in void graves or crypts, resulting from the accumulation of fluids (decomposed brain tissue) at a focal point within the skull.
mmune-related gene expression in response to H 11 N 9 low pathogenic avian nfluenza virus infection in chicken and Pekin duck peripheral blood ononuclear cells

The duck and chicken are important hosts of avian influenza virus (AIV) with distinctive responses to infection. Frequently, AIV infections in ducks are asymptomatic and long-lasting in contrast to the clinically apparent and transient infections observed in chickens. These differences may be due in part to the host response to AIV infection. Using real-time quantitative PCR, we examined the expression of immune-related genes in response to low pathogenic AIV H11N9 infection in peripheral blood mononuclear cells (PBMC) isolated from the blood of chickens and Pekin ducks. While chicken PBMC expressed IL-1 and IL-6 at high levels similar to mammalian species, duck PBMC expression levels were minimal or unchanged. Similarly, duck IFNexpression was nearly unaffected, whereas chicken expression was highly upregulated. Chicken IFNwas expressed to higher levels than duck IFN, while IFNwas expressed similarly by both species. IL-2 was elevated early in infection in duck PBMC, but returned to baseline levels by the end of the experiment; in contrast, IL-2 was weakly induced in chicken PBMC at late time points. TLR-7 and MHC class I molecule expressions were conserved between species, whereas duck nterferon gamma
EFFECT OF EUCAL YPTUS CAMALDULENSIS ON THE YIELD OF WHEAT AND MAIZE CROPS AFTER REDUCING TREE DENSITY

The study was conducted at Punjab Forestry Research Institute, Faisalabad, Pakistan. It examined the effect of Eucalyptus camaldulensis on yield of agricultural crops after reducing the tree density. E. camaldulensis was planted in 1993 at three different spacing; 6' x 6', 6' x 10', 6' x12'. In 1995 alternate rows of plants were removed to increase the spacing; 6' x 12' meters (rn) (Treatment 1;T1), 6' x 20' m (Treatment 2;T2), 6' x 24' m (Treatment 3; T3) and a plot without trees was retained as control (Treatment 4; T4). Wheat and maize were intercropped during June and September from 1995 to 1997. Each treatment was replicated thrice The yield of wheat grain, wheat straw and maize crops was measured from1995 to 1997 using 1m quadrate. The yield of agricultural crop was high in T4. The yield of wheat grain and straw was high in T2 and T3 as compared to Tt. The yield of maize fodder was not different between T1, T2 and T3.
The doubly green revolution. Food for all in the twenty-first century.

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Mid-Miocene rhyolite volcanism in northeastern Nevada: The Jarbidge Rhyolite and its relationship to the Cenozoic evolution of the northern Great Basin (USA)

We present new physical, geochemical, geochronologic, and oxygen isotope constraints on the mid-Miocene Jarbidge Rhyolite in northeastern Nevada (USA), providing new constraints on the tectonomagmatic evolution of the Cenozoic northern Great Basin. Widespread extension due to rapid collapse of the Nevadaplano began at ca. 17–16 Ma across the northern Great Basin. Coeval with this event was compositionally bimodal basalt-rhyolite volcanism that is often attributed to the inception of the Yellowstone hotspot. The most widespread mid-Miocene volcanic units in northeastern Nevada are lavas and domes of the Jarbidge Rhyolite. The thickest and most areally extensive exposures of these lavas include, and are found just west of, the Jarbidge Mountains, Nevada. This study focuses on Jarbidge Rhyolite directly south of the central Snake River Plain, adjacent to the thickest exposures in the vicinity of Jarbidge, Nevada. Textures on a range of scales indicate that the Jarbidge Rhyolite consists primarily of phenocryst-rich lavas. Laser 40 Ar/ 39 Ar ages for sanidine are consistent with effusive eruption of metaluminous to slightly peraluminous ferroan calc-alkalic rhyolite from 16.1 to 15.0 Ma; prior K-Ar ages suggest that some activity occurred over a slightly longer duration. Major and trace element data, coupled with new stable and prior radiogenic isotope measurements, suggest that Jarbidge Rhyolite magmas formed primarily via melting of quartzofeldspathic crust. The Jarbidge Rhyolite lavas are geochemically dissimilar from younger Snake River Plain rhyolites (e.g., lower MgO, lower Nb, higher Rb/Nb) and are more similar to coeval rhyolites erupted to the west on or adjacent to the Oregon Plateau. The distribution of the Jarbidge Rhyolite lavas in northeastern Nevada reflects an intimate association with temporally and spatially coincident extension rather than the Yellowstone hotspot.
The effect of flower and fruit thinning on the firmness of ‘Cox’s Orange Pippin’ apples at harvest and after storage

In two out of three years the removal of all but the first axillary flower or fruitlet 5 or 37 d after full-bloom, respectively, increased the firmness of ‘Cox’ apples at harvest and after storage in 1.25% o2 (<1% Co2) at 3.5°C. Thinning 19 d after full bloom did not increase firmness. Firmness increase in fruit from thinned trees was accompanied by higher dry matter and P concentration in the fruit at harvest. Fruits from thinned trees were larger, less dense and contained more K and less Ca than those from unthinned trees. Thinning tended to increase susceptibility to physiological storage disorders.
NOAA-AVHRR NDVI decomposition and subpixel classification using linear mixing in the Argentinean Pampa

Abstract Crop Normalized Difference Vegetation Index (NDVI) time profiles and crop acreage estimates were derived from the application of linear mixture modelling to Advanced Very High Resolution Radiometer (AVHRR) data over a test area in the southern part of the Pampa region, Argentina. Bands 1 and 2 from seven AVHRR scenes (June to January 1991) were combined to produce fraction images of winter crops, summer crops and pastures. A Landsat Thematic Mapper (TM) scene of the region was classified and superimposed to the AVHRR Local Area Coverage (LAC) data by means of a correlation technique. Each class signature was extracted by regressing the AVHRR response on the cover types proportions, estimated from Landsat-TM data, over sets of calibration windows. The crop NDVI profiles were hence derived from the class signatures in bands 1 and 2. These profiles appeared consistent with the cover types, but variability depending on the set of windows was noted. The assessment of the class signatures was indirectl.
Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188 nucleotides long, and that of the adw clone was 3200 nucleotides long. The adr and adw clones differed from the reported cloned ayw HBV DNA (3182 nucleotides long) in 11.2% and 10.0% of nucleotides, respectively. Heterogeneity of the HBV genome in the clones with the same subtype was observed.
Contributions à l'inférence statistique en présence de censure multivariée

L'objectif de cette these est d'explorer plusieurs approches pour l'etude des donnees censurees multivariees, a savoir l'estimation non parametrique de la fonction de repartition jointe, la modelisation de dependance par les modeles de copules et l'etude exploratoire par des methodes de clustering. Le Chapitre 1 introduit le contexte general de cette these ainsi que ses contributions. Le Chapitre 2 est consacre a l'estimation de la distribution jointe des deux variables censurees dans le cadre d'un modele de duree simplifie ou la difference entre deux variables de censure est observee. Un nouvel estimateur non parametrique de la fonction de repartition jointe y est introduit. La normalite asymptotique a ete demontree, pour les integrales par rapport a la mesure definie par cet estimateur. Le Chapitre 3 est dedie a la problematique de l'estimation non parametrique de la copule bivariee, a partir d'un echantillon de donnees censurees. La copule est d'abord estimee par une fonction discrete qui peut etre interpretee comme une extension de la copule empirique en presence de censure, puis par ses versions lisses. Les proprietes asymptotiques et des applications de des estimateurs ont ete considerees. Le Chapitre 4 presente une approche exploratoire pour l'etude de donnees censurees. Plus precisement, une configuration multivariee est consideree ou une variable est une duree sujette a la censure, et toutes les autres variables sont observees. Sous ces conditions, une nouvelle methode de quantification de la loi jointe est introduite. La methode est etudiee theoriquement et appliquee a la construction d'un algorithme de clustering pour des observations censurees.
Index of transversally elliptic operators

— In the 70's, the notion of analytic index has been extended by Atiyah and Singer to the class of transversally elliptic operators. They did not, however, give a general cohomological formula for the index. This was accomplished many years later by Berline and Vergne. The Berline-Vergne formula is an integral of a non-compactly supported equivariant form on the cotangent bundle, and depends on rather subtle growth conditions for these forms. This paper gives an alternative expression for the index, where the non-compactly supported form is replaced with a compactly supported one, but with generalized coefficients