Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Framework of Public Risk Assessment Using an Integrated Approach Based on AHP and Psychometric Paradigm

Understanding how the public perceives various risks and hazards associated with our well-being and health is crucial for governments and policymakers. The present research aimed to assess the public perception of various risks and hazards associated with well-being and health. The study combined two well-known risk assessment approaches: the analytical hierarchical process (AHP) and the psychometric paradigm. Seven risk attributes were chosen from the risk perception literature to evaluate 27 risks and hazard activities using a survey questionnaire developed based on the psychometric paradigm literature. The collected data were then analyzed using the AHP to determine the priority weight for each risk attribute. The results showed that the most crucial risk attribute was voluntariness of risk, followed by chronic catastrophic and newness of risk. Furthermore, the study found that natural hazards were ranked the highest, followed by refugee influx and fire hazards. In contrast, the mobile phone was perceived as posing the lowest type of risk. Policymakers can use these findings to develop effective and sustainable risk communication strategies to help the governments to inform and educate the public about potential risks, improve coordination among agencies and stakeholders, and enhance public trust in government decision making.
Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (Oncorhynchus mykiss) following Oral Administration

Simple Summary Doxycycline, an approved aquacultural antibiotic, is extensively used in the treatment of bacterial diseases in fish. Since fish are poikilothermic organisms, their body temperature and metabolic rate are primarily influenced by the temperature of the water. Therefore, temperature may be affected by pharmacokinetic behavior and withdrawal times of drugs. The current study was undertaken to look at the differences in pharmacokinetics, tissue residues, and withdrawal times of doxycycline following oral administration in rainbow trout reared at 10 and 17 °C. The increment of water temperature from 10 to 17 °C decreased the elimination half-life, the body clearance, and the distribution volume of doxycycline and increased plasma concentrations. The withdrawal times for plasma and tissues decreased with the temperature increase. The results contributed to the determination of an optimal dosing regimen and the safe consumption of edible tissues in rainbow trout that were administered doxycycline and reared at different temperatures. Abstract The purpose of this study was to compare the pharmacokinetics, tissue residues, and withdrawal times of doxycycline after oral administration in rainbow trout reared at 10 and 17 °C. Fish received a 20 mg/kg oral dose of doxycycline after a single or 5-day administration. Six rainbow trout were used at each sampling time point for plasma and tissue samples, including liver, kidney, and muscle and skin. The doxycycline concentration in the samples was determined using high-performance liquid chromatography with ultraviolet detector. The pharmacokinetic data were evaluated by non-compartmental kinetic analysis. The WT 1.4 software program was used to estimate the withdrawal times. The increase of temperature from 10 to 17 °C shortened the elimination half-life from 41.72 to 28.87 h, increased the area under the concentration–time curve from 173.23 to 240.96 h * μg/mL, and increased the peak plasma concentration from 3.48 to 5.50 μg/mL. At 10 and 17 °C, the doxycycline concentration was obtained in liver > kidney > plasma > muscle and skin. According to the MRL values stated for muscle and skin in Europe and China (100 μg/kg) and in Japan (50 μg/kg), the withdrawal times of doxycycline at 10 and 17 °C were 35 and 31 days, respectively, for Europe and China and 43 and 35 days, respectively, for Japan. Since temperature significantly affected pharmacokinetic behavior and withdrawal times of doxycycline in rainbow trout, temperature-dependent dosing regimens and withdrawal times of doxycycline might be necessary.
Ordinary Muon Capture on 136Ba: Comparative Study Using the Shell Model and pnQRPA

In this work, we present a study of ordinary muon capture (OMC) on 136Ba, the daughter nucleus of 136Xe double beta decay (DBD). The OMC rates at low-lying nuclear states (below 1 MeV of excitation energy) in 136Cs are assessed by using both the interacting shell model (ISM) and proton–neutron quasiparticle random-phase approximation (pnQRPA). We also add chiral two-body (2BC) meson-exchange currents and use an exact Dirac wave function for the captured s-orbital muon. OMC can be viewed as a complementary probe of the wave functions in 136Cs, the intermediate nucleus of the 136Xe DBD. At the same time, OMC can be considered a powerful probe of the effective values of weak axial-type couplings in a 100 MeV momentum exchange region, which is relevant for neutrinoless DBD. The present work represents the first attempt to compare the ISM and pnQRPA results for OMC on a heavy nucleus while also including the exact muon wave function and the 2BC. The sensitivity estimates of the current and future neutrinoless DBD experiments will clearly benefit from future OMC measurements taken using OMC calculations similar to the one presented here.
Upregulation of Neuropilin-1 Inhibits HTLV-1 Infection

Infection with human T-cell leukemia virus type 1 (HTLV-1) can produce a spectrum of pathological effects ranging from inflammatory disorders to leukemia. In vivo, HTLV-1 predominantly infects CD4+ T-cells. Infectious spread within this population involves the transfer of HTLV-1 virus particles from infected cells to target cells only upon cell-to-cell contact. The viral protein, HBZ, was found to enhance HTLV-1 infection through transcriptional activation of ICAM1 and MYOF, two genes that facilitate viral infection. In this study, we found that HBZ upregulates the transcription of COL4A1, GEM, and NRP1. COL4A1 and GEM are genes involved in viral infection, while NRP1, which encodes neuropilin 1 (Nrp1), serves as an HTLV-1 receptor on target cells but has no reported function on HTLV-1-infected cells. With a focus on Nrp1, cumulative results from chromatin immunoprecipitation assays and analyses of HBZ mutants support a model in which HBZ upregulates NRP1 transcription by augmenting recruitment of Jun proteins to an enhancer downstream of the gene. Results from in vitro infection assays demonstrate that Nrp1 expressed on HTLV-1-infected cells inhibits viral infection. Nrp1 was found to be incorporated into HTLV-1 virions, and deletion of its ectodomain removed the inhibitory effect. These results suggest that inhibition of HTLV-1 infection by Nrp1 is caused by the ectodomain of Nrp1 extended from virus particles, which may inhibit the binding of virus particles to target cells. While HBZ has been found to enhance HTLV-1 infection using cell-based models, there may be certain circumstances in which activation of Nrp1 expression negatively impacts viral infection, which is discussed.
Alpha-Defensin 1: An Emerging Periodontitis Biomarker

Background: Research on the development of reliable diagnostic targets is being conducted to overcome the high prevalence and difficulty in managing periodontitis. However, despite the development of various periodontitis target markers, their practical application has been limited due to poor diagnostic accuracy. In this study, we present an improved periodontitis diagnostic target and explore its role in periodontitis. Methods: Gingival crevicular fluid (GCF) was collected from healthy individuals and periodontitis patients, and proteomic analysis was performed. The target marker levels for periodontitis were quantified in GCF samples by enzyme-linked immunosorbent assay (ELISA). Mouse bone marrow-derived macrophages (BMMs) were used for the osteoclast formation assay. Results: LC-MS/MS analysis of whole GCF showed that the level of alpha-defensin 1 (DEFA-1) was higher in periodontitis GCF than in healthy GCF. The comparison of periodontitis target proteins galactin-10, ODAM, and azurocidin proposed in other studies found that the difference in DEFA-1 levels was the largest between healthy and periodontitis GCF, and periodontitis was more effectively distinguished. The differentiation of RANKL-induced BMMs into osteoclasts was significantly reduced by recombinant DEFA-1 (rDEFA-1). Conclusions: These results suggest the regulatory role of DEFA-1 in the periodontitis process and the relevance of DEFA-1 as a diagnostic target for periodontitis.
Impact of the Covering Material on Drought Tolerance Responses and Soil Water Content in Two Cultivars of Young Blueberry Plants under Protected Cultivation

There is a lack of information on how protected cultivation alters plant and soil responses to water stress. The objective of this study was to understand the influence of the covering material on drought tolerance responses and soil water content in the effective rooting zone in two promising new cultivars grown under contrasting climatic conditions. (2) Methods: Two experiments were conducted in young blueberry (Vaccinium corymbosum L.) orchards, cv. Blue Ribbon and cv. Top Shelf, in two different locations in the south-central region of Chile (Linares and Traiguén) in 2018–2019 and 2019–2020. Four treatments (uncovered control, net, woven, and plastic) were installed from bud break to leaf senescence. (3) Results: Woven and plastic-covered plants showed no relationship between stem water potential and stomatal conductance, while uncovered and net-covered plants showed a quadratic relationship between both variables. Under deficit irrigation, higher plant water status, stomatal conductance, and photosystem II efficiency were found in covered plants. ‘Top Shelf’ showed greater tolerance to water stress than ‘Blue Ribbon’ due to more sensitive stomatal control. (4) Conclusions: Protected cultivation delayed the onset of water stress, maintained high stomatal conductance, and reduced photoinhibition in young blueberry plants.
Influence of organization communication on employee’s job motivation and job performance in the broadcast organizations in Delta State, Nigeria

The core of this study was to examine via inferential and descriptive statistics, the statistical correlation between organization communication on employee’s job motivation and job performance in the broadcast organizations in Delta State, Nigeria. This study was anchored on the unitary theory of industrial relations due to its relevance to the scope of this study. To achieve the general and specific objective of this study, the descriptive survey research design was adopted and primary data were obtained from questionnaire responses administered to one hundred and seventy-one staff of the seven broadcast organizations used for the study. Hypotheses were formulated and tested and findings emerged. The findings revealed that, job motivation indicators has no significant linear relationship with employee job motivation in broadcast organizations in Delta State; job performance indicators has a significant positive linear relationship with employee job performance in broadcast organizations in Delta State; Organizational communication has a significant positive linear relationship with employee job motivation in broadcast organizations in Delta State and that Organizational communication has no significant linear relationship with employee job performance in broadcast organizations in Delta State. This study will help management of different industries to find the most crucial factors before implementing their motivational policies.
Vibrational Spectroscopy of Phytochromes

Phytochromes are biological photoswitches that translate light into physiological functions. Spectroscopic techniques are essential tools for molecular research into these photoreceptors. This review is directed at summarizing how resonance Raman and IR spectroscopy contributed to an understanding of the structure, dynamics, and reaction mechanism of phytochromes, outlining the substantial experimental and theoretical challenges and describing the strategies to master them. It is shown that the potential of the various vibrational spectroscopic techniques can be most efficiently exploited using integral approaches via a combination of theoretical methods as well as other experimental techniques.
FINANCIAL INCLUSION, MSMEs AND ITS IMPACT ON DEPOSIT MONEY BANKS PERFORMANCE IN NIGERIA

This study examined the impact of financial inclusion on financial performance of listed Deposit Money Banks (DMBs) in Nigeria. The study measured financial inclusion using Micro, Small and Medium Enterprises Financing, Rural Financing, Number of branches of DMBs, Pricing and Usage of banking services, while performance was measured with return on assets (ROA). This study adopted ex-post facto research design. The population of the study comprised of the 14 listed deposit money banks on the Nigerian Stock Exchange for the period of 2005-2018. The study censured all the 14 listed DMBs as the sample size. The study collected secondary data from Central Bank of Nigeria statistical bulletin and financial reports of the sampled banks. Panel multiple regression analysis was utilized to analyse the data and Hausman specification test revealed that fixed effect model was more appropriate to random effect model. Test for adequacy were performed on the residuals and the results indicated that the residuals were homoskedastic and had no serial correlation, suggesting that the model is good. The study found that rural financing and number of branches of deposit money banks have statistically significant effects on profitability of DMBs in Nigeria. The study concluded that financial inclusion improves profitability of DMBs in Nigeria. Based on the findings, this study recommended that DMBs should increase the amount of loan and advances given to rural areas and Micro, Small and Medium Enterprises as this will strengthen profitability of DMBs in Nigeria.
Gabapentin: Clinical Use and Pharmacokinetics in Dogs, Cats, and Horses

Simple Summary Gabapentin is an anticonvulsant drug effective in humans to control neuropathic pain. In veterinary medicine, is extra-label used in combination with other treatments to control seizures when other drugs are not effective, when drugs are toxic, or for neuropathic pain treatment and anxiety. This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. In dogs, gabapentin was useful in the treatment of epilepsy, as well as chronic, neuropathic, and post-operative pain and anxiety. In cats, it was effective in post-ovariohysterectomy-related pain and in the management of anxiety. In horses, it has been administered as an analgesic for chronic pain. In conclusion, when used in combination with other drugs, gabapentin is an interesting therapeutic option for the treatment of neuropathic diseases and analgesia. Despite its beneficial use in different clinical settings, further trials and pharmacokinetic studies are needed for the definition of an effective dosage regimen through proper pharmacokinetic/pharmacodynamic correlation in dogs, cats, and horses. Abstract Gabapentin is an anticonvulsant drug, which presents an established clinical efficacy in human patients for the management of refractory partial seizures, secondarily generalized tonic-clonic seizures, and for the control of chronic neuropathic pain. Gabapentin was synthesized as a structural analogue of the inhibitory neurotransmitter GABA, with GABA-mimetic effects, able to cross the blood–brain barrier. In veterinary medicine, is extra-label used in combination with other treatments to control seizures when other drugs are no longer effective or become toxic or for neuropathic pain treatment and anxiety. This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. In dogs, gabapentin was beneficial in the treatment of epilepsy, as well as chronic, neuropathic, and post-operative pain, as well as anxiety. In cats, it showed efficacy in post-ovariohysterectomy-related pain and in anxiety management. In horses, gabapentin has been administered as an analgesic for chronic pain management. In conclusion, when used in combination with other drugs, gabapentin can be considered an interesting therapeutic option for the treatment of neuropathic diseases and analgesia in postoperative and chronic pain. However, despite its beneficial use in different clinical settings, further trials and pharmacokinetic studies are needed for the definition of an effective dosage regimen through proper pharmacokinetic/pharmacodynamic correlation in dogs, cats, and horses.
Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus

Background: Granular cell tumors (GCT) are rare neoplasms of Schwann cell origin occurring in the skin and in other organs. The etiopathogenesis of GCT is yet poorly understood. Connexin 43 (Cx43) is the most broadly expressed gap junction protein in humans, the tumoral role of which has been investigated in several types of tumors. Its role in GCT of the skin, oral cavity and gastrointestinal tract is as yet unknown. Methods: Herein, we present a study on the immunohistochemical expression of Cx43 in GCT of the skin (n = 15), tongue (n = 4) and esophagus (n = 3). Immunolabeling was scored positive (weak (+), moderate (++) or strong (+++)). Results: Cx43 was expressed by all cases of GCT of the skin, tongue and esophagus (22/22), showing moderate to strong staining. All tissue sections of GCT were characterized by a diffuse, cytoplasmic staining pattern of the tumor cells. None of those showed membranous or nuclear staining. Conclusion: Our results suggest that Cx43 probably plays an important role in the development of this rare tumor entity.
Goat Pleomorphic Adenoma Gene 1 (PLAG1): mRNA Expression, CNV Detection and Associations with Growth Traits

Simple Summary The pleomorphic adenoma gene 1 (PLAG1) gene has attracted a lot of attention as a gene related to myogenesis. The PLAG1 gene is a key gene for growth traits in sheep, cattle, pigs, and chickens. However, it has also become the focus of research to determine whether it is the dominant gene affecting growth traits in goats. To address this problem, a bioinformatics analysis, mRNA expression (n = 6), and identification of copy number variants (CNVs) (n = 224) of PLAG1 were conducted in Shaanbei white cashmere (SBWC) goats. The findings indicated that the gene had a large number of conserved motifs, the expression level of the gene was higher in fetal goats than in adult goats, and all CNV loci were found to be associated with goat growth traits (p < 0.05), making them effective molecular marker loci for goat breeding. Abstract The pleomorphic adenoma gene 1 (PLAG1) gene, as the major gene responsible for growth, plays a vital role in myogenesis. Meanwhile, the relationship between copy number variation (CNV) of this gene and growth traits in goats remains unclear. Therefore, this study investigated four aspects: bioinformatics analysis, mRNA expression (n = 6), CNV detection (n = 224), and association analysis. The findings indicated that the gene had a large number of conserved motifs, and the gene expression level was higher in fetal goats than in adult goats. Three CNV loci were selected from the database, among which CNV1 was located in the bidirectional promoter region and was associated with goat growth traits. CNV analysis showed that CNV2 and CNV3 of the PLAG1 gene were associated with growth traits such as body weight, heart girth, height at hip cross, and hip width (p < 0.05), with CNV1 loss genotype being the superior genotype, and CNV2 and CNV3 median and gain genotypes of being superior genotypes. This finding further confirms that the PLAG1 gene is the dominant gene for growth traits, which will serve as theoretical guidance for goat breeding.
Studies on integrated nutrient management on yield of blackgram (Vigna mungo L.) in Chhattisgarh plain

A field experiment was conducted at the Instructional farm, BTC CARS, Bilaspur (C.G.) university of Indira Gandhi Krishi Vishwavidyalaya, Raipur (Chhattisgarh). During kharif, season of 2021 with a view to study the “Studies on integrated nutrient management on yield of blackgram (Vigna mungo L.) In Chhattisgarh plain”. The Blackgram (urdbean) used to grown and treatment was replicated three times in randomized block design. The soil of experimental site was alfisol belonging to textural clay loam. The investigation has recommended dose of fertilizer (RDF) i.e., 20:40:20 kg N, P2O5, K2O ha which were applied at different concentrations in blackgram in seven treatments viz., T1: 20:40:20 RDF, T2: 125%RDF, T3:150% RDF, T4:RDF + FYM@5t ha, T5:125% of RDF + FYM@5t ha, T6:150% of RDF + FYM@5t ha and T7: Control(NPK). The yield parameters i.e., number of pods plant, number of seeds pod, pod length (cm), 1000 seed weight (g), seed yield q ha, straw yield q ha and harvest index (%) were significantly superior in the treatment T6 (150% of RDF + FYM@5t ha). On the basis of above findings, treatment T6 (150% of RDF + FYM@5t ha) stand could be better performance first in position and T5 (125% of RDF + FYM@5t ha) stand in second order of preference. However, treatment T3 (150% RDF) comes in next in order. Therefore, it may be concluded that treatment T6 (150% of RDF + FYM@5t ha) may be prefer for higher yield in blackgram.
Conventional Platinum Metal Implants Provoke Restenosis Responses in Atherogenic but Not Healthy Arteries

Platinum-containing stents are commonly used in humans with hypercholesterolemia, whereas preclinical stent evaluation has commonly been performed in healthy animal models, providing inadequate information about stent performance under hypercholesterolemic conditions. In this investigation, we used an ApoE−/− mouse model to test the impact of hypercholesterolemia on neointima formation on platinum-containing implants. We implanted 125 μm diameter platinum wires into the abdominal aortas of ApoE−/− and ApoE+/+ mice for 6 months, followed by histological and immunofluorescence examination of neointimal size and composition. It was found that ApoE−/− mice developed neointimas with four times larger area and ten times greater thickness than ApoE+/+ counterparts. Neointimas developed in the ApoE−/− mice also contained higher amounts of lipids quantified as having 370 times more coverage compared to ApoE+/+, a 3-fold increase in SMCs, and a 22-fold increase in macrophages. A confluent endothelium had regenerated in both mouse strains. The ApoE−/− mice experienced luminal reductions more closely resembling clinically relevant restenosis in humans. Overall, the response to platinum arterial implants was highly dependent upon the atherogenic environment.