Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical characteristics and current treatment of critically ill patients with COVID-19 outside Wuhan, China: a multicenter, retrospective, observational study

Background: A novel coronavirus disease 2019 (COVID-19) occurred in Wuhan and rapidly spread elsewhere. The clinical characteristics and treatment of critical ill patients outside Wuhan remain unknown. We aimed to describe the epidemiology and treatment of critical ill patients with COVID-19 in Hebei province.Methods: All patients were from designated hospitals of Hebei province and fit the criteria. We collected the clinical data, laboratory examinations and treatment of all participants.Results: By 14 February 2020, 37 critical ill patients were included. The mean age of the patients was 58.73 (SD 13.76) years, 21 (56.80%) patients were men, 18 (48.60%) were familial cluster, 26 (70.30%) patients had chronic illness. The patients with critical type had a longer period of confirmation time, more severe inflammation and lung injury, a lower lymphocyte percentage. All patients were treated with antiviral agents, 33 (89.20%) with antibacterial agents, 35 (95.60%) patients with methylprednisolone and traditional Chinese drugs. Nine (60.00%) patients with critical type were treated with invasive mechanical ventilation, 9 (60.00%) of those with complications. The patients with critical type received more fluid and more diuretics.Conclusion: Patients with underlying disease and the confirmation time> 10 days were more likely to develop to critical type. The critical type patients had higher risk of infection, respiratory depression, circulatory collapse, and complications. The strategy of lung-protective mechanical ventilation and restrictive fluid management should be strictly followed.
VISUAL PERCEPTION OF PRIMARY DISPLAY PANEL OF COFFEE PACKAGING

Previous research only discussed the perception of color combinations for the primary display panel. This study is not only focused on color; but also on other visual elements. This research aims to know the primary display panel that is more desirable to consumers and uncover the linkage between product perception and preference by using quantitative approach. As for the method used is the case study of brand Puntang Coffee. Data collection was done by conducting literature study, redesign experiment and questionnaires, whereas data analyze by using the ANOVA test. From data, it was revealed that the highest valuation of respondents of all three designs displayed is design C; which proposed by the designer team, that are perceived better by respondents.
Two Different Growth Mechanisms for Au-Free InAsSb Nanowires Growth on Si Substrate

We present a study of Au-free InAsSb nanowire (NW) growth on Si (111) substrate under different growth parameters including V/III ratio, group Sb flow rate fraction (Sb-FRF, TMSb/(TMSb+AsH3)), and temperature. It was found that two different kinds of growth mechanisms for the Au-free InAsSb NW growth may be dominant depending on the growth parameters. At low V/III ratio and relatively high Sb-FRF, the NWs grow via vapor–liquid–solid (VLS) mode, while at high V/III ratio and relatively low Sb-FRF, they grow via vapor–solid (VS) mode. The NWs obtained by the two growth modes show clear differences in morphology, growth direction, and crystal quality. Under VS mode, the NWs exhibit unified growth direction and a uniform composition distribution, which are beneficial to integration devices of multiple NWs. On the other hand, under VLS mode, the NWs are first reported with pure crystal phase, which will be useful for the development of single NW devices.
Study of Demographic Pattern of Poisoning in Patients Presenting to Emergency Department of a Tertiary Care Centre, SIMS, Hapur

Poisoning is a common medical emergency and one of the important cause of mortality and morbidity in developing countries like India due to easy availability of poisonous substances and its low cost. This study was carried out on poisoning cases reported to casualty of Saraswathi Institute of Medical Sciences, Hapur, UP in eighteen-months duration from 1st January 2017 to 30th June 2018. In this study, incidence was more among men (58.70%) compared to women (41.30%) and maximum cases were of age group 21 – 30 years (48.91%). More cases from rural area (89.13%) were reported and highest number of poisoning cases were admitted in the month of June 2018 (10.87%) followed by May 2017 (8.70%). Maximum cases (60.87 %) reported to casualty between 8am to 4pm. Aluminium phosphide poisoning (44.26%) constituted the highest number of cases and in maximum cases manner of poisoning was of suicidal in nature (59.78%). Majority of cases 53.26% were discharged after improvement and 3.26% cases died.
On the perpetuation and contestation of racial stigma: Urban Roma in a disadvantaged neighbourhood of Szeged

Stigmatisation of Roma people has long received attention in the academic literature but the internalisation of stigma among segregated urban Roma has been little researched. By adopting a theoretical perspective on collective identity and (urban Roma) racial stigmatisation, this paper aims to 1) understand the broader nature of urban Roma stigmatisation maintained by the non-Roma people and among the Roma, and 2) better position the internalisation of stigma and the burden of Roma stigmatisation. The paper uses Participatory Action Research (PAR) as a research methodology, taking a disadvantaged neighbourhood of the city of Szeged, Hungary as a case study. The findings suggest that stigmatisation against urban Roma is a process which has deeply rooted historical backgrounds, and current efforts which strive for desegregation and integration of urban Roma will be difficult to implement, as stigmatisation remains in the collective mentality. The importance of this study rests on bringing all major dimensions of stigma together, highlighting what policymakers should consider when addressing them in the longer term. We argue that the existing urban policies towards the Roma people need to be readdressed, with clear power given to the voices of the Roma, particularly from institutions which aim to protect them.
A summary of the fifth annual Virology Education HIV Microbiome workshop.

This year marked the fifth meeting of the International Workshop on Microbiome in HIV held at the NIH1-4. In the past year, appreciation for the interplay between the human microbiome and HIV infection has continued to grow. New studies presented here help clarify the role of the microbiome on chronic inflammation and vaccine design and reveal the interaction between the effects of genetics, environment, sexual practice and HIV infection on the microbiome. Further, reports on the development and clinical trials of microbiome-based therapeutic approaches investigate the potential of microbiome alterations to decrease the probability of acquisition/transmission or ameliorate sequellae of HIV. Essential to all studies is the continued development and standardization of best methods for data analysis and consistency across studies and approaches. The keynote address by Dr. Jacques Ravel focused on his work to improve the analysis and resolution of microbiome data.
The integration of leadership in an educational and social environment: case study "El Fouarate School"

Leadership is a general principle. Finding the proper leadership style has long been of great interest to researchers. Various specialties worked out their own concepts and models. The three-dimensional model is one of the popular ones in education. However, the model is based on business concepts, the new content may return useful additions. The paper presents the structure and the content of the three-dimensional model in a Moroccan educational scene. The focus points of students, participation and knowledge can be translated to the employee’s engagement and effectiveness. I consider the model as an initial framework in this paper. It is to see if educational leadership is actually practiced in Moroccan schools, as well as the impact of the educational leadership on academic success.
The effect of paper versus realized losses on subsequent risk-taking: field evidence from casino gambling.

In this paper, we test the realization effect, i.e., that risk-taking increases after a paper loss, whereas risk-taking decreases after a realized loss, using gambling data from a real casino. During a particular casino visit, losses are likely perceived as paper losses because the chance to offset prior losses remains effective until leaving the casino. However, when casino customers leave the casino, the final account balance is realized. Using individual-level slot machine gambling records, we find that risk-taking after paper losses increases during a visit and that this effect is more pronounced for larger losses. Conversely, risk-taking across multiple visits is not altered if the realized losses are comparatively small, whereas risk-taking is reduced if realized losses are comparatively large.
Administrator Perceptions of Academic Advisor Tasks

As higher education leaders, chief academic officers are capable of affecting the ways advising is structured and performed on college campuses, but little is known about how they regard advising. This study investigated the perceptions of 181 chief academic officers at two- and four-year public and private institutions in the U.S. regarding advising tasks. Using a Likert-scale instrument built using the NACADA core competencies, we explored how chief academic officers' perceptions of advisor tasks represent the informational, relational, and conceptual areas of the core competencies. Results revealed small significant differences between institutional type in perceptions of advising roles and functions. This study lays the foundation for future inquiry into perceptions of chief academic officers and other key stakeholders of advising.
The Property Lobby

Book Abstract: Despite countless reports and Government policy announcements on the housing crisis over decades, the scale and depth of the crisis continues. Homelessness, shortages of social housing, rents and house prices continue rise year on year. The word affordability has become meaningless. Land landowners and housebuilders and property investors have made huge profits out of this crisis. This book focusing in examples from London and Northamptonshire examines the power of the ‘finance-housebuilding ’ complex arguing that this property lobby is the main blockage for change and reform. It explains why the housing and planning system has become increasingly dysfunctional over the last 40 years accelerating with the impact of the 2008 Crash. The book gives examples of how the property lobby has been highly effective in manipulating Government housing and planning policy for its own benefit, to the detriment of those in housing need. It shows how the housebuilders business model, backed by Government grants and subsidies, has played a central role in perpetuating the crisis. The property lobby has succeeded in diverting attention from themselves onto the town planning system which has been scapegoated for holding back new house building. The result is that the housing crisis and the power behind it is hard baked into the UK economy. It must be addressed by radical reform of the property, planning and finance system. Without these reforms homelessness, poor housing, and lack of affordability will continue indefinitely.
Manche Masemola: Rebel or Revolutionary? Resistance and Subversion in the Manche Masemola Narrative

Manche Masemola’s narrative is predominantly a portrayal of a strong-willed character who faces brutal attacks for her commitment to her faith. She is described as a martyr, and eventually a saint. Her struggle to project her voice and willingness to make her own decisions are largely reported from one side, that is, from the perspective of the Church recounting how she defied her parents and community to accept the Christian religion. Commentators on this narrative miss Manche’s willingness to defy the same Church that was ready to promote her as a martyr. The purpose of this article is to argue that although Manche was described as an Anglican martyr, she was a revolutionary, and resisted the same Empire that hoped to colonise and Christianise her. She resisted colonial enslavement and continued to be initiated into koma, and refused to be baptised with Western clothing. Manche should be seen as a model for resistance against colonialism and female struggles against masculine dominance clothed in Christian education and conversion. The article uses archival records and secondary analysis to describe Manche’s pursuit to die for her commitment to her Sepedi culture. I will begin by examining Manche’s ritual journey to adulthood using koma, and conclude by discussing the pertinent question of why she was finally not baptised.
Motivating Adherence to Exercise Plans Through a Personalized Mobile Health App: Enhanced Action Design Research Approach

Background Physical inactivity is a global issue that affects people’s health and productivity. With the advancement of mobile technologies, many apps have been developed to facilitate health self-management. However, few studies have examined the effectiveness of these mobile health (mHealth) apps in motivating exercise adherence. Objective This study aims to demonstrate the enhanced action design research (ADR) process and improve the design of mHealth apps for exercise self-management. Specifically, we investigate whether sending motivational messages improves adherence to exercise plans, whether the motivational effect is affected by personality, the impact of message type and repetition, and the process of involving a field experiment in the design process and learning new design principles from the results. Methods This formative research was conducted by proposing an enhanced ADR process. We incorporated a field experiment into the process to iteratively refine and evaluate the design until it converges into a final mHealth app. We used the Apple ResearchKit to develop the mHealth app and promoted it via trainers at their gyms. We targeted users who used the app for at least two months. Participants were randomly assigned to 1 of the 12 groups in a 2×3×2 factorial design and remained blinded to the assigned intervention. The groups were defined based on personality type (thinking or feeling), message type (emotional, logical, or none), and repetition (none or once). Participants with different personality types received tailored and repeated messages. Finally, we used the self-reported completion rate to measure participants’ adherence level to exercise plans. By analyzing users’ usage patterns, we could verify, correct, and enhance the mHealth app design principles. Results In total, 160 users downloaded the app, and 89 active participants remained during the 2-month period. The results suggest a significant main effect of personality type and repetition and a significant interaction effect between personality type and repetition. The adherence rate of people with feeling personality types was 18.15% higher than that of people with thinking types. Emotional messages were more effective than logical messages in motivating exercise adherence. Although people received repeated messages, they were more likely to adhere to exercise plans. With repeated reminders, the adherence rates of people with thinking personality types were significantly improved by 27.34% (P<.001). Conclusions This study contributes to the literature on mHealth apps. By incorporating a field experiment into the ADR process, we demonstrate the benefit of combining design science and field experiments. This study also contributes to the research on mHealth apps. The principles learned from this study can be applied to improve the effectiveness of mHealth apps. The app design can be considered a foundation for the development of more advanced apps for specific diseases, such as diabetes and asthma, in future research.
Farm diversification as a potential success factor for small-scale farmers constrained by COVID-related lockdown. Contributions from a survey conducted in four European countries during the first wave of COVID-19

This paper explores to what extent product and marketing channel diversification contributed to the economic success of small-scale agricultural producers involved in short food supply chains after the outbreak of the COVID-19 pandemic. A survey was conducted between April and July 2020 in four countries of the European Union–Estonia, Hungary, Portugal and Romania,–resulting in a relatively large sample of farmers (N = 421). The analysis was built on a semi-nonparametric approach. Approximately 19 percent of small-scale producers were able to increase sales during the first wave of the pandemic, although country-level variation was significant. Fruits and vegetables were by far the most popular products. The importance of specific channels varied across countries, but farm gate sales were among the most important marketing channels both before and during the first wave. The importance of channels that were based on digital resources and home delivery increased. Our evidence indicates that diversification was a strategy that paid off, both in terms of marketing channels and different product categories. However, the impact appears to be nonlinear; the initial advantage generated by diversification rapidly tapered off, either temporarily (in the case of products), or permanently (in the case of marketing channels). Later research may clarify whether these findings are generalizable in other socio-economic contexts, as well as in a non-COVID situation.
Curcumin loaded on graphene nanosheets induced cell death in mammospheres from MCF-7 and primary breast tumor cells

Elimination of tumor cells is still a therapeutic challenge for breast cancer (BC) in men and women. Mammospheres serve as valuable in vitro tools for evaluating tumor behavior and sensitivity to anticancer treatments. Graphene nanosheets with unique physicochemical properties have been considered as potential biomedical approaches for drug delivery, bioimaging, and therapy. Graphene oxide (GO) and graphene quantum dots (GQDs) are suitable nanocarriers for hydrophobic and low bioaccessible anti-tumor materials like curcumin. Despite extensive studies on the potential application of graphene nanosheets in medicine, our knowledge of how different cells function and respond to these nanoparticles remains limited. Here, we evaluated cell death in mammospheres from MCF-7 and primary tumor cells in response to curcumin loaded on graphene nanosheets. Mammospheres were exposed to graphene oxide-curcumin (GO-Cur) and graphene quantum dots-curcumin (GQDs-Cur), and the incidence of cell death was evaluated by Hoechst 33342/propidium iodide double staining and flow cytometry. Besides, the expression of miR-21, miR-29a, Bax, and Bcl-2 genes were assessed using RT-qPCR. We observed, GO, and GQDs had no cytotoxic effect on Kerman male breast cancer/71 (KMBC/71) and MCF-7 tumor cells, while curcumin induced death in more than 50% of tumor cells. GO-Cur and GQDs-Cur synergistically enhanced anti-tumor activity of curcumin. Moreover, GQDs-Cur induced cell death in almost all cells of KMBC/71 mammospheres (99%; p < 0.0001). In contrast, GO-Cur induced cell death in only 21% of MCF-7 mammosphere cells (p < 0.0001). Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur. Although KMBC/71 and MCF-7 tumor cells had similar clinical features and displayed similar responses to curcumin, more investigations are needed to clarify the detailed molecular mechanisms underlying observed differences in response to GO-Cur and GQDs-Cur.
eVITTA: a web-based visualization and inference toolbox for transcriptome analysis

Abstract Transcriptome profiling is essential for gene regulation studies in development and disease. Current web-based tools enable functional characterization of transcriptome data, but most are restricted to applying gene-list-based methods to single datasets, inefficient in leveraging up-to-date and species-specific information, and limited in their visualization options. Additionally, there is no systematic way to explore data stored in the largest transcriptome repository, NCBI GEO. To fill these gaps, we have developed eVITTA (easy Visualization and Inference Toolbox for Transcriptome Analysis; https://tau.cmmt.ubc.ca/eVITTA/). eVITTA provides modules for analysis and exploration of studies published in NCBI GEO (easyGEO), detailed molecular- and systems-level functional profiling (easyGSEA), and customizable comparisons among experimental groups (easyVizR). We tested eVITTA on transcriptomes of SARS-CoV-2 infected human nasopharyngeal swab samples, and identified a downregulation of olfactory signal transducers, in line with the clinical presentation of anosmia in COVID-19 patients. We also analyzed transcriptomes of Caenorhabditis elegans worms with disrupted S-adenosylmethionine metabolism, confirming activation of innate immune responses and feedback induction of one-carbon cycle genes. Collectively, eVITTA streamlines complex computational workflows into an accessible interface, thus filling the gap of an end-to-end platform capable of capturing both broad and granular changes in human and model organism transcriptomes.
Effect of Chilling on Quality Control Parameters of Sterile Queensland Fruit Fly (Diptera: Tephritidae)

Abstract Queensland fruit fly (Q-fly), Bactrocera tryoni (Froggatt), presents a major threat to Australian fruit production and trade. The sterile insect technique (SIT) is increasingly employed to manage Q-fly. Quality of sterile males released in SIT programs, and hence program efficacy, can be affected by pre- and post-production processes, such as mass rearing, packing, irradiation, transportation, and release. Given long distances from rear-out facilities to release sites, adult flies are usually chilled to reduce metabolism and stress during transportation. To guide SIT procedures, it is important to understand the impact of such practices on performance of sterile Q-fly. The present study assesses the effect of chilling temperature and exposure period on quality parameters of sterile Q-fly. We considered the effects of two temperature regimes (4 and 6°C) and six exposure periods (0, 1, 2, 4, 6, and 12 h) on chill-coma recovery time, flight ability, survival under nutritional stress, and longevity of both males and females. Flies chilled at 4°C took longer to recover than that those chilled at 6°C. Flight ability, survival under nutritional stress, and longevity all decreased as chilling period increased but did not differ between the two tested temperatures. We recommend that periods of chilling during transportation from rear-out facilities to release sites be minimized in order to retain quality of sterile Q-fly and that increased release rates be considered when longer chilling periods are required.