Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_348025 155..163

1Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China Background: Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are promising weight-loss drugs, but real-world data concerning the liability of GLP-1RAs in gastrointestinal safety are lacking. We examined the differences in gastrointestinal safety between semaglutide and liraglutide. Materials and Methods: We used the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database and retrieved data during the first three years of semaglutide and liraglutide approved by the FDA. Thirteen main gastrointestinal adverse drug reactions (GADRs) were evaluated. Patient demographics, treatment information, and outcome of events were summarized. Disproportionality analyses were conducted by estimating the reporting odds ratios (RORs) and 95% confidence intervals (CIs). Results: In the reported cases of semaglutide (n = 2047) and liraglutide (n = 4175), semaglutide had a higher pooled ROR and later pooled time-to-onset median of GADRs compared with those of liraglutide (5.53, 95% CI 5.23–5.85 vs 3.95, 95% CI 3.81–4.10; 7 days, Q1–Q3: 0–48 vs 4 days, Q1–Q3: 0–34.5). The thirteen GADRs associated with these two GLP-1RAs showed a significant difference in the profile of reporting risk and time-to-onset. Conclusion: GLP-1RAs produce a spectrum of distinct classes of GADRs. The individual properties of GADRs between semaglutide and liraglutide might enable incretin-based treatment of obesity to be “tailored” to the needs of each patient.
Compact planar UWB MIMO antenna with on-demand WLAN rejection

Presented are two different frequency reconfigurable ultra-wideband multiple-input multiple-output (MIMO) antenna array designs capable of rejecting on-demand all WLAN communications in the 4.8 to 6.2 GHz range. Both arrays consist of two monopole UWB radiators placed orthogonally with respect to each other to introduce polarisation diversity and a quarter-wave stub connected to the ground plane via pin diodes is used to introduce the on-demand band rejection feature. One array design has separate ground planes and the other has two ground planes connected with a printed conductor (i.e. shared). For both cases, an isolation better than 20 dB between the elements is achieved in the 2 to 12 GHz frequency range with simulations and a manufactured prototype.
Prevalence, trend and associated risk factors of Mother-to-Child Transmission of HIV among HIV-exposed infants

Background: The Human Immunodeficiency Virus (HIV) Mother-To-Child-Transmission (MTCT) can primarily occur during pregnancy, birth and breastfeeding. However, there is limited recent evidence from large-scale study on MTCT of HIV in Ethiopia. Thus, this study was aimed to determine the prevalence, trend and associated risk factors of MTCT among HIV-exposed infants. Methodology: A cross-sectional study was conducted on 5,679 infants whose specimen referred to Ethiopian Public Health Institute HIV referral laboratory from January 01, 2016 to December 31, 2020. Required information was obtained from Early Infant Diagnosis (EID) database. Frequencies and percent were used to describe the distribution of the infants. Logistic regression analysis was used to identify factors associated with HIV infection. The level of significance was set at 5%. Results: The mean age of the infants was 12.64 (±14.62) weeks with 4 to 72 weeks range. Half of the infants (51.4%) were female. Prevalence of HIV infection over the course of five years among HIV-exposed infants (HEI) was 2.6%. The prevalence of MTCT decreased from 2.9% in 2016 to 0.9% in 2020. After adjusting for covariates; infant testing after six weeks (Adjusted odds ratio (AOR) = 2.7; 95% confidence interval (CI): (1.8–4.0, )) p-value <0.001, absence of Prevention of Mother-To-Child-Transmission (PMTCT) service (AOR = 4.6; 95% CI: (2.9–7.4)) p-values =0.001, mother being on daily prophylaxis at birth (AOR = 2.0; 95% CI: (1.3–3.2)) p-value <0.001, and mother HIV status before date of delivery (AOR =11; 95% CI: (5.5–22.1)) p-value <0.001 were significantly associated with MTCT of HIV. Conclusion: The prevalence of MTCT of HIV is considerable. However, the prevalence was declining during the study period. Tested after six weeks for EID, unavailability of PMTCT service were the factors associated with HIV infection among HEI. Strengthen PMTCT service and early HIV screening of pregnant women are critical to reduce HIV infection among HEI.
Disturbed gastric motility in patients with long-standing diabetes mellitus

Purpose: Gastric dysmotility has been reported in patients with long-standing diabetes mellitus (DM). Some patients with DM are diagnosed as diabetes gastroparesis and have several upper gastrointestinal (GI) symptoms such as appetite loss and abdominal pain. This study aimed to identify the relationship between gastric motility and upper GI symptoms in patients with long-standing DM. Method: This study was conducted among 23 patients with DM and 15 healthy controls. All the patients with DM were receiving insulin treatment and had at least one history of incidence of diabetic nephropathy, retinopathy or neuropathy. Gastric motility was evaluated using electrogastrography (EGG) and gastric emptying using the 13C-acetic acid breath test. The most severe upper gastrointestinal symptoms were assessed in all patients. Results: Compared to healthy controls, patients with long-standing DM showed a significantly lower percentage of normogastria at the postprandial state with a lower power ratio in EGG. Gastric emptying was significantly delayed in patients with DM in the overall analysis. Sixteen patients with DM (69.6%) demonstrated abnormalities in either gastric myoelectrical activity or gastric emptying. Among patients with abnormal EGG or delayed gastric emptying, 12 had some GI symptoms, compared with 3 patients with normal gastric motility. No significant correlation was observed between the gastric emptying parameters and HbA1c values. Conclusion: Patients with long-standing DM showed gastric dysmotility, including impaired gastric myoelectrical activity and delayed gastric emptying. Gastric dysmotility appears to be closely correlated with upper GI symptoms in patients with long-standing DM.
Comparison of Cultivated and Wild Relatives of Several Forage Species in Mixed Rangeland Based on Some Nutritional Characteristics

: Cultivated forage species may have higher nutrients contents (NC) and forage quality indicators (FQI) than their wild relatives. Nine forage samples collected five times from a mixed rangeland and an experimental field during two consecutive years was analysed for ash, crude protein (CP), ether extract (EE) and neutral detergent (NDF) and acid detergent (ADF) fibres. Then, their FQI such as digestible dry matter (DDM), dry matter intake (DMI), metabolizable energy (ME) and relative forage quality (RFQ) were calculated. Data were performed in a linear model with fixed effects (forage plant type [PT] and species [PS]) to NC and FQI, and subjected to hierarchical two-way clustering analysis. Cultivated and wilds relatives varied in CP (12.0-18.9% and 8.8-23.3%), ADF (20.9-33.1% and 39.3-73.5%) and NDF (37.2-61.6% and 26.7-46.1%) contents and ME (8.7-9.7 MJ kg -1 DM and 7.0-9.6 MJ kg -1 DM) and RFQ (98.8-186.7 and 74.6-161.7) values. There were interactions between PT and PS for all NC and FQI, except for CP and EE contents. In general, the CP, EE, ADF, ME and RFQ of cultivars were higher, whereas NDF was lower than those of the wilds. The most notable differences (NDF, ADF and RFQ) between the PT represented the differences in nutritional traits based on the clustering analysis. The cultivated and wilds relatives are comprised of NC and FQI that respond differently under same circumstances.
Effects of urea supplementation on ruminal fermentation characteristics, nutrient intake, digestibility, and performance in sheep: A meta-analysis

Background and Aim: As a non-protein nitrogen source, urea is a popular, low cost, and easily obtained protein supplement. The objective of the present study was to perform a meta-analysis of the effects of urea supplementation on rumen fermentation and sheep performance. Materials and Methods: A total of 32 experiments from 21 articles were compiled into a dataset. The levels of dietary urea varied from 0 to 31 g/kg of dry matter (DM). Parameters observed were rumen fermentation product, nutrient intake, nutrient digestibility, and sheep performance. This dataset was analyzed using a mixed model methodology, with urea supplementation levels as fixed effects and the different experiments as random effects. Results: Increasing levels of urea were associated with increases (p=0.008) in rumen pH, butyrate (C4) production, and ammonia (NH3–N) concentration. Urea supplementation had minor effects on total volatile fatty acids (p=0.242), total protozoa (p=0.429), and the microbial N supply (p=0.619), but tended to increase methane production (CH4; p<0.001). Supplementation of urea increased the intake of dry matter (DM; p=0.004) and crude protein (CP; p=0.001). Digestibility parameters, such as DM digestibility (DMD) and CP digestibility (CPD), also increased (p<0.01) as a result of urea supplementation. Retained N (p=0.042) and N intake (p<0.001) were higher with increasing levels of urea supplementation. In terms of animal performance, supplementation of urea increased average daily gain (ADG; p=0.024), but decreased the hot carcass weight percentage (p=0.017). Conclusion: This meta-analysis reports the positive effects of urea supplementation on rumen fermentation products (i.e., pH, C4, and NH3–N), intake (DM, CP, and N), digestibility (DMD and CPD), and ADG in sheep.
Wireless Transmissions, Propagation and Channel Modelling for IoT Technologies: Applications and Challenges

The Internet of Things (IoT) has rapidly expanded for a wide range of applications towards a smart future world by connecting everything. As a result, new challenges emerge in meeting the requirements of IoT applications while retaining optimal performance. These challenges may include power consumption, quality of service, localization, security, and accurate modeling and characterization of wireless channel propagation. Among these challenges, the latter is critical to establishing point-to-point wireless communication between the sensors. Channel modeling also varies depending on the features of the surrounding area, which have a direct impact on the propagation of wireless signals. This presents a difficult task for network planners to efficiently design and deploy IoT applications without understanding the appropriate channel model to analyze coverage and predict optimal deployment configurations. As a result, this challenge has attracted considerable interest in academic and industrial communities in recent years. Therefore, this review presents an overview of current breakthroughs in wireless IoT technologies. The challenges in such applications are then briefly reviewed, focusing on wireless channel propagation modeling and characterization. Finally, the study gives a generalized form of commonly used channel models and a summary of recent channel modeling developments for wireless IoT technology. The outcome of this review is expected to provide a new understanding of the propagation behavior of present and future wireless IoT technologies, allowing network engineers to undertake correct planning and deployment in any environment. Additionally, the study may serve as a guideline for future channel modeling and characterization studies.
Occurrence and Habitat Use of Non-native Small Mammals in Upland Urban-Forest Environment in Northern Philippines

In the Philippines, few researches have been conducted about small mammals in urban areas at high elevation, where forests remain and non-native pest species can proliferate. Previous studies in Baguio City, Benguet Province reported three non-native species. This study extended these prior surveys by sampling in 13 localities, employing standard trapping method to document the distribution of species in an urban-forest setting. In 4,711 trap nights, 94 individuals were captured, consisting of four non-native species: Rattus exulans, Rattus tanezumi, Mus musculus, and Suncus murinus. Analysis of occurrence and relative abundance of species showed that small mammal distribution varied among the habitats, and appeared that variation may have been related to differences in vegetation structure or a habitat’s disturbance level. Rattus tanezumi was the most widespread, being especially common in backyard farms and in the public market. Suncus murinus was also widespread but less abundant than R. tanezumi. Rattus exulans was uncommon and restricted to certain area of a given habitat, particularly preferring weed-dominated areas. These suggest that non-native species are common and widespread in urban-forest setting but with apparent habitat preferences. The non-detection of native species is notable, suggesting that thorough studies can be done in the future.
Computational Model of Taste Pathways: A Biomimetic Algorithm for Electronic Tongue Based on Nerve Conduction Mechanism

Research on the taste conduction mechanisms of data processing by the electronic tongue (e-tongue) is lacking. These mechanisms affect taste substance identification by the e-tongue system. This work proposed a computational model of taste pathways based on nerve conduction mechanisms to identify taste substances. This work modelled human taste pathways based on the Katchalsky models and validated the rationality of the modelling forms of the critical pathway structures. Next, this work simulated the response status and power spectral density of the model nodes and verified the bionic performance of the computational model. The results showed, first, that the computational model described the dynamic characteristics of the taste pathways. Second, the phase diagrams of the pathway structures revealed chaotic characteristics. This result showed that the modelling forms were rational. Third, when stimulated, the model nodes exhibited fast responses. During stimulation, the power spectral density of the model nodes demonstrated 1/ ${f}$ characteristics. The fast-response ability and 1/ ${f}$ characteristics reflected the bionic performance of the computational model. Finally, the computational model was used to identify beer, tea, and apple samples. Compared with other classification methods, the computational model achieved better classification results of 93.33%, 94.00%, and 76.67%, the best specificity of 0.9833, 0.9850, and 0.9417, and the best Kappa coefficients of 0.9180, 0.9261, and 0.7245 for the identification of the beer, tea, and apple samples, respectively. In conclusion, the computational model can effectively identify taste substances.
The Using of Multiplex RT-qPCR for Pooled Samples to Detect Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus within Iraqi Blood Donors

Background: The blood of blood donors is screening for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection by enzyme immunoassay (EIA) in the National Center of Blood Bank in Baghdad. The residual risk of EIA negative samples is not estimated till now in Iraq. Objective: To detect HBV, HCV and HIV viruses within seronegative plasma of blood donors by a commercially available multiplex nucleic acid amplification tests (NAT) with mini-pooling system. Methods: One thousand (1000) blood donors were screened by EIA revealed negative results then NAT was performed on pools of samples, each pool contain ten seronegative plasmas (MP10) i.e., 100 minipools. Results: The detected positive minipools 10 seronegative plasmas by NAT for HBV, HCV and HIV were 3 MP10. Conclusion: The use of NAT appeared to be sensitive and reliable to detect occult HBV and overcome the seroconversion problem related with HCV and HIV within seronegative plasmas of blood donors. Therefore, the implementation of NAT with mini-pooling in addition to serological tests for routine blood donor screening will improve and ensure the safety of blood transfusion in Iraq. Keywords: Blood transfusion, widow period, multiplexes PCR Citation: Majid GS, Abdulamir AS, Ahmed AM, Aufi IM, Abdullah OI. The using of multiplex RT-qPCR for pooled samples to detect hepatitis B virus, hepatitis C virus, human immunodeficiency virus within Iraqi blood donors. Iraqi JMS. 2021; 19(1): 99-106. doi: 10.22578/IJMS.19. 1.13
Combination Therapy with GABA and MgSO4 Improves Insulin Sensitivity in Type 2 Diabetic Rat

Background Gamma-aminobutyric acid (GABA) and magnesium sulfate (MgSO4) play a crucial role in glycemic control. Therefore, we studied the effect of combination therapy with GABA and MgSO4 to improve insulin sensitivity in diabetes induced by streptozotocin as well as high-fat diet in a diabetic rat model. Design and Methods. Forty randomly selected rats were assigned to four groups: nondiabetic control group was fed the normal diet, insulin-resistant diabetic rat model was induced by streptozotocin and high-fat diet, GABA + MgSO4 group received GABA and MgSO4, and insulin group was treated with insulin. Body weight, abdominal fat, blood glucose, serum insulin, and glucagon concentration were measured. The glucose clamp technique, glucose tolerance test, and insulin tolerance test were performed to study insulin sensitivity. Also, the expressions of glucose 6 phosphatase, glucagon receptor, and phosphoenolpyruvate carboxykinase genes in liver were assessed for the gluconeogenesis pathway. Protein translocation and glucose transporter 4 (Glut4) genes expression in muscle were also assessed. Results Combination of GABA + MgSO4 or insulin therapy enhanced insulin level, glycemic control, glucose and insulin tolerance test, some enzymes expression in the gluconeogenesis pathway, body fat, body weight, and glucagon receptor in diabetic rats. Moreover, an increase was observed in protein and gene expression of Glut4. Insulin sensitivity in combination therapy was more than the insulin group. Conclusions GABA and MgSO4 enhanced insulin sensitivity via increasing Glut4 and reducing the gluconeogenesis enzyme and glucagon receptor gene expressions.
C-C Chemokine Receptor 7 in Cancer

C-C chemokine receptor 7 (CCR7) was one of the first two chemokine receptors that were found to be upregulated in breast cancers. Chemokine receptors promote chemotaxis of cells and tissue organization. Since under homeostatic conditions, CCR7 promotes migration of immune cells to lymph nodes, questions immediately arose regarding the ability of CCR7 to direct migration of cancer cells to lymph nodes. The literature since 2000 was examined to determine to what extent the expression of CCR7 in malignant tumors promoted migration to the lymph nodes. The data indicated that in different cancers, CCR7 plays distinct roles in directing cells to lymph nodes, the skin or to the central nervous system. In certain tumors, it may even serve a protective role. Future studies should focus on defining mechanisms that differentially regulate the unfavorable or beneficial role that CCR7 plays in cancer pathophysiology, to be able to improve outcomes in patients who harbor CCR7-positive cancers.
Leading Teaching and Learning in the Era of Education 4.0: The Relationship between Perceived Teacher Competencies and Teacher Attitudes toward Change

Abstract: The objective of the survey was to examine the relationship between perceived teacher competencies in the era of Education 4.0 (TCEdu4.0) and teacher attitudes toward change (TATC) in Malaysian secondary schools. A total of 1,293 teachers from 80 secondary schools that were chosen using disproportionate stratified sampling method completed the questionnaires with valid data. The results demonstrated that, i) there was a significant, positive and strong correlation between TCEdu4.0 and TATC; and ii) except Functional and Research Competency, Self-Management and Interactive Competency, Leading Learning and Mentoring, Problem Solving, Technological and Digital Competency, and Pedagogical Psychology and Assessment were the five predictors of TATC that contributed 49.20% to the total variation. The study re-affirms the practicality of the competency and planned behavioural theories, provides evidence that teacher’s individual factor is a major determinant of attitudes toward change. Moreover, it expands the understanding among educational practitioners regarding the interplay between these two variables and is a significant resource for Institut Aminuddin Baki in developing future training programmes for school leaders in enhancing TCEdu4.0 and TATC. In summary, the study offers valuable insights for driving school change effectively that sustainable school change is correlated to individual factors. Keywords: Teacher Competencies, Teacher Attitudes Toward Change, Education 4.0, Fourth Industry Revolution, School change
Druggable Molecular Pathways in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults, is characterized by a high degree of clinical heterogeneity that is influenced by the disease’s molecular complexity. The genes most frequently affected in CLL cluster into specific biological pathways, including B-cell receptor (BCR) signaling, apoptosis, NF-κB, and NOTCH1 signaling. BCR signaling and the apoptosis pathway have been exploited to design targeted medicines for CLL therapy. Consistently, molecules that selectively inhibit specific BCR components, namely Bruton tyrosine kinase (BTK) and phosphoinositide 3-kinase (PI3K) as well as inhibitors of BCL2, have revolutionized the therapeutic management of CLL patients. Several BTK inhibitors and PI3K inhibitors with different modes of action are currently used or are in development in advanced stage clinical trials. Moreover, the restoration of apoptosis by the BCL2 inhibitor venetoclax offers meaningful clinical activity with a fixed-duration scheme. Inhibitors of the BCR and of BCL2 are able to overcome the chemorefractoriness associated with high-risk genetic features, including TP53 disruption. Other signaling cascades involved in CLL pathogenesis, in particular NOTCH signaling and NF-kB signaling, already provide biomarkers for a precision medicine approach to CLL and may represent potential druggable targets for the future. The aim of the present review is to discuss the druggable pathways of CLL and to provide the biological background of the high efficacy of targeted biological drugs in CLL.