Miracle-dz/UniFAR-FTUs huggingface dataset:
Wounded Warriors and Their Transition to the Community College Classroom

Wounded Warriors and Their Transition to the Community College Classroom by Virgil N. Adkins MA, Webster University, St. Louis, MO, 2003 BS, Park University, Parkville, MO, 1999 AA, Monterey Peninsula College, Monterey, CA, 1998 Project Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Education Walden University February 2019 Abstract Many postsecondary institutions face challenges when veterans with posttraumatic stress disorder (PTSD) or traumatic brain injury (TBI) enroll in college and become student-veterans. Staff and faculty may need to better understand how to accommodate these student-veterans as they transition from military to student life. The purpose of this study was to explore theMany postsecondary institutions face challenges when veterans with posttraumatic stress disorder (PTSD) or traumatic brain injury (TBI) enroll in college and become student-veterans. Staff and faculty may need to better understand how to accommodate these student-veterans as they transition from military to student life. The purpose of this study was to explore the perspectives of 3 groups at a Texas community college regarding classroom accommodations for student-veterans with PTSD or TBI: (a) student-veterans with PTSD or TBI, (b) the faculty, and (c) the disability counselors. Schlossberg’s theory assessing an individual’s assets and abilities in transition was the conceptual framework for this study. The research questions asked about the perspectives of student-veterans with PTSD or TBI, the faculty, and the disability services staff. A case study design was used, and inclusion criteria included 5 enrolled student-veterans with a PTSD or TBI diagnosis, 5 faculty members who have taught student-veterans, and 3 Disability Resource Center (DRC) staff at the community college. Semi-structured interview questions aligned with the research questions and data were analyzed for credibility, reliability, interpretation, and themes related to classroom accommodations. Findings from the study revealed student participants felt more could be done to accommodate student-veterans. Faculty participants expressed concerns regarding a lack of training related to accommodations. DRC participants reported reluctance from some student-veterans to use accommodations. Findings contribute to positive social change by identifying gaps in practices and by aiding staff and faculty with professional development to better provide accommodations for student-veterans with PTSD or TBI. Wounded Warriors and Their Transition to the Community College Classroom by Virgil N. Adkins MA, Webster University, St. Louis, MO, 2003 BS, Park University, Parkville, MO, 1999 AA, Monterey Peninsula College, Monterey, CA, 1998 Project Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Education
Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy

Targeted therapy is an efficient treatment for patients with epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). Therapeutic resistance invariably occurs in NSCLC patients. Many studies have focused on drug resistance mechanisms, but only a few have addressed the metabolic flexibility in drug-resistant NSCLC. In the present study, we found that during the developing resistance to tyrosine kinase inhibitor (TKI), TKI-resistant NSCLC cells acquired metabolic flexibility in that they switched from dependence on glycolysis to oxidative phosphorylation by substantially increasing the activity of the mitochondria. Concurrently, we found the predominant expression of monocarboxylate transporter 1 (MCT-1) in the TKI-resistant NSCLC cells was strongly increased in those cells that oxidized lactate. Thus, we hypothesized that inhibiting MCT-1 could represent a novel treatment strategy. We treated cells with the MCT-1 inhibitor AZD3965. We found a significant decrease in cell proliferation and cell motility in TKI-sensitive and TKI-resistant cells. Taken together, these results demonstrated that gefitinib-resistant NSCLC cells harbored higher mitochondrial bioenergetics and MCT-1 expression. These results implied that targeting mitochondrial oxidative phosphorylation proteins or MCT-1 could serve as potential treatments for both TKI-sensitive and –resistant non-small cell lung cancer.
The authors reply.

e162 www.ccmjournal. org February 2020 • Volume 48 • Number 2 R&D Promotion Programme and Japan Agency for Medical Research and Development. Dr. Shime received KAKENHI funding from the Japan Society for the Promotion of Science (Number JP 17K11573). Dr. Ohshimo received funding from the Strategic Information and Communications R&D Promotion Programme. Drs. Ohshimo and Shime received funding from the Japan Agency for Medical Research and Development. The remaining authors have disclosed that they do not have any potential conflicts of interest.
Research progress in refractory sudden hearing loss: steroid therapy

Sudden sensorineural hearing loss (SSNHL) is a common condition with a rapid onset, and its worldwide frequency is increasing each year. Importantly, a significant number of patients with SSNHL do not respond to initial treatment, which is termed refractory sudden hearing loss (RSHL), and further treatment is not standardized in terms of type, duration, administration route, and concentration of topical steroid therapy. Dexamethasone and methylprednisolone are effective in treating RSHL, and salvage treatment typically consists of 2 weeks of steroid therapy followed by 3–6 months of follow-up. Near-continual steroid perfusion appears to be more effective than intermittent steroid injection. Furthermore, several novel therapeutic regimens have shown promising results in small-scale studies. However, the optimum treatment needs to be confirmed in larger randomized controlled trials.
'I just stopped going' : a mixed methods investigation into dropout from psychological treatment in adolescents with depression

While the effectiveness of psychological treatment for adolescent depression is well established, there is concern about high dropout rates. Using a mixed-methods design, this thesis sought to understand therapy dropout in the context of adolescent depression, drawing on data from a randomised controlled trial. Study 1 aimed to investigate whether dropout could be predicted from a range of child, family and treatment factors (N = 406). Increase in age and antisocial behaviour, and decrease in verbal intelligence, were found to be significant predictors of dropout. More missed sessions and poorer therapeutic alliance were also significant predictors of dropout. Study 2 aimed to investigate whether those who dropped out of therapy had poorer clinical outcomes compared with those who completed therapy. No strong evidence was found for dropouts having poorer outcomes than completers. Study 3 aimed to explore whether there was a more clinically meaningful way of classifying dropout. Interviews with adolescents (N = 32) and therapists for ‘dropout’ cases were analysed qualitatively using ideal type analysis. Three types of dropout were constructed. ‘Dissatisfied’ dropouts stopped therapy because they did not find therapy helpful; ‘got-what-they-needed’ dropouts stopped therapy because they did not feel a need to continue in therapy; and ‘troubled’ dropouts stopped therapy because they did not have the stability in their life to commit to the therapy. Study 4 aimed to investigate the role of the therapeutic alliance and rupture-repair processes in the lead up to a ‘dissatisfied’ dropout compared to other types of therapy ending. ‘Dissatisfied’ dropouts were found to have more ruptures in the therapeutic alliance, and ruptures were frequently unresolved, compared with completers and ‘got-what-they-needed’ dropouts, indicating a more difficult interaction pattern prior to ‘dissatisfied’ dropout. Together, these studies have implications for how different types of disengagement from treatment should be managed in clinical practice.
Waiting to fail: a comparative study of effective school configurations for at-risk sixth grade students

The purpose of this comparative study was to examine the relationship between student achievement and social-emotional well-being in three different school configurations for at-risk sixth grade students. This study sought to apply the stage-environment fit theory to investigate the effect of mismatched school environments on young adolescents when developmental changes occur. The mixed methods research measured academic and behavioral success and school connectedness using surveys and focus group interviews. The sample was made of 109 sixth grade students who qualified as at-risk in three northwest states. Results indicated alternative schools deliver supports that meet the academic and developmental needs of young adolescents by providing personalized and structured learning in a smaller environment. In addition, elementary schools were also found to have positive effects on academics through their use of effective teaching methodologies due to structured lessons and small ability groups. A student’s sense of connectedness was paramount in the findings of meeting the socialemotional needs of this marginalized population. Quantitative and qualitative results supported the elementary and alternative schools’ ability to provide students with a culture of care and support afforded through active engagement and personalized connections. Alternative students were found to have deeper conversations and stronger connections to their teachers resulting in statistically significant results according to teacher relationships from the survey and focus interviews. Alternative schools found a decrease in discipline and absenteeism as compared to at-risk students in elementary and middle schools. The behavioral results from the alternative configuration found the implementation of a sound positive behavioral intervention program was the factor that separated the alternative school program from the elementary and middle school configurations.
Upward mobility for women managers: styles and perceptions: part two

Purpose – The purpose of this two-part article is to discover why gender plays a significant role in attaining leadership positions. More specifically this article provides a thorough review of the different gender leadership styles, next it outlines the findings regarding whether one gender is more effective than the other on certain dimensions. The article presents the findings of how certain leadership perceptions have evolved. Finally the article will review the challenges faced by women in business contexts. Design/methodology/approach – The authors reviewed a wide array of published works on ‘‘gender and leadership’’ to gain insight on this broad topic. Next, the authors narrowed down their review to focus on four specific aspects of the said topic: gender leadership styles, gender effectiveness on certain dimensions, leadership perceptions and challenges women face. Findings – The literature on the reviewed four aspects suggests that the most effective leadership style is transformational leadership – the style of leadership that is most often associated with women. It was also found that certain behavioral traits found in female managers are considered to be more effective when dealing with employees, such as empathy, supportiveness, and relationship building. However, there are other traits such as vision where male managers tend to rank better than female managers. Research limitations/implications – The use of a literature review may be perceived as limiting but the scope and breadth of contemporary data and empirical finding utilized in this article has more than compensated for this issue. Practical implications – The number of working women has and continues to increase, yet the number of women in senior positions of organizations remains nearly unchanged as women are still perceived as inferior leaders when compared to men. Social implications – Women are perceived as being less capable than men in leadership roles, thus hindering their aspirations to climb the corporate ladder. What is more, women also find themselves struggling with issues such as the glass ceiling and glass cliff effect as well as balancing both motherhood and career obligations, limiting their workplace advancements. Originality/value – A useful source to provide arguments as to how and why women demonstrate excellent managerial skill sets. Also, the ill-conceived communication silos regarding the perceived notion that women are deemed inferior leaders when compared to their male counterparts are challenged.
The effectiveness of adolescent support teams

This study evaluates the effectiveness of adolescent support teams in achieving positive outcomes for young people at risk of care or accommodation. It reports on a prospective, comparative study carried out in eight English local authorities. Both quantitative and qualitative methods were used to compare services and outcomes for young people referred to specialist family support teams working with adolescents with those for a group receiving mainstream social work services. A sample of 209 young people was recruited to the study. Interviews with young people, parents and workers were carried out shortly after referral and again at six month follow-up. The study describes the characteristics, circumstances and histories of the young people referred to both types of service, providing evidence of their high levels of need. Interventions by specialist and mainstream services are described and outcomes on a range of dimensions are compared, namely in terms of child and family functioning, child perceptions of well-being, severity of child difficulties, parental mental health and placement. The question of how, why and in what circumstances the interventions were likely to be more or less successful is also explored. The study found that for the majority of the young people circumstances improved on a range of measures. However, there was no evidence that the specialist teams were more successful in improving child and family functioning than mainstream services, although there was some indication that they were more successful in preventing placement.
Rheumatoid Neutrophilic Dermatosis: The Distinct Entity with Florid Presentation

Sir, Rheumatoid neutrophilic dermatosis (RND) is a very rare cutaneous manifestation of severe rheumatoid arthritis (RA). [1] It usually presents as chronic, asymptomatic, symmetric erythematous and urticaria‐like plaques and papules. The annular, vesicular, ulcerative or necrotic lesions are less frequently reported in a single patient. The diagnosis is confirmed on histology which shows dense dermal neutrophils with leukocytoclasia but no vasculitis, a feature described for sweet syndrome. [2]
Cephalic vein approach for the implantable central venous access

Abstract Long-term venous access is usually required in patients receiving chemotherapy. We hypothesized that, out of the various central line approach techniques, the cephalic vein cut-down technique can be a safe and simple alternative in terms of surgical safety, feasibility, cost-effectiveness, and functional outcomes. We retrospectively reviewed the medical records of 569 patients who underwent implantable central venous access between January 2012 and December 2014 at our hospital. We classified our cohort according to access routes, as follows: 230 patients underwent subclavian vein access, 134 patients underwent internal jugular vein access, 25 patients underwent external jugular vein access, and 119 patients underwent cephalic vein access. The cephalic vein group had a significantly longer operation time than the subclavian group (P < .01); however, there was no difference in operation time between the internal jugular vein and cephalic vein groups (P = .59). The procedure-related complications and functional outcomes of the implanted venous port during chemotherapy were comparable between the cephalic group and other groups. Additionally, body mass index, operation time, and age did not correlate with catheter dysfunction in the multivariate logistic regression analysis (P = .53; P = .66; P = .19, respectively). We suggest that a cut-down central venous catheter insertion through the cephalic vein can be performed easily and safely with no differences in surgical and clinical outcomes compared to those of conventional percutaneous approaches. Moreover, the cephalic vein approach requires no specialized equipment, including percutaneous vascular kits, tunneling instruments, and intraoperative ultrasonography. Therefore, this technique might incur less medical expenses than conventional approaches and would be helpful for both patients and surgeons.
Human white matter microstructure predicts elite sports participation

Collision-sport athletes, especially football players, are exposed to a higher number of repetitive head impacts. Little is known, however, regarding the effects of long-term exposure to repetitive head impacts on brain tissue structure and the locations (i.e. superficial or deep tissue structures) affected. On top of this, little is known about the effects of highly competitive athletics on brain tissue structure. We investigated this relationship, including the baseline effect of collegiate athletic participation, by mapping measures of microstructure to cortical and subcortical white matter parcels and major white matter tracts of varsity IU football players, cross-country runners, and non-athlete students using advanced microstructural mapping techniques and machine-learning. We tested a series of hypotheses on the differences between the subject groups. To do so, we implemented an innovative approach to statistical hypothesis testing combining advanced white matter tissue properties and machine-learning classifiers. We used cross-validation to select the best subject group model and best machine-learning classifier. Wide-spread differences in brain tissue microstructure across cortical, subcortical, and major white matter structures were documented. The tissue properties of the major white matter tracts were found to best predict collision-sport participation and sports participation in general, however, cortical and subcortical white matter parcels were also found to predict collision-sports participation. The biggest differences in brain tissue microstructure is between the athletes (football and cross country combined) and the non-athletes students. The rewards and risks of playing competitive sports at the highest collegiate level may account for the differences in brain microstructure. This was the first investigation into the effects of repetitive head impacts to use an open-source data processing platform ​brainlife.io​. The data and code for these analyses are available via ​brainlife.io​. Acknowledgments. ​This research was supported by NSF OAC-1916518, NSF IIS-1912270, NSF, IIS-1636893, NSF BCS-1734853, NIH NIDCD 5R21DC013974-02, NIH 1R01EB029272-01, the Indiana Spinal Cord and Brain Injury Research Fund, Google Cloud, a ​Microsoft Research Award​, the Indiana University Areas of Emergent Research initiative “Learning: Brains, Machines, Children. ” We thank Soichi Hayashi, David Hunt and Steven O’Riley for contributing to the development of brainlife.io, Craig Stewart, Robert Henschel, David Hancock and Jeremy Fischer for support with jetstream-cloud.org (NSF ACI-1445604). We also thank The Indiana University Lawrence D. Rink Center for Sports Medicine and Technology and Center for Elite Athlete Development for contributing funding to athletic scientific research and for the development of a new research facility.
Predicting the number of visceral leishmaniasis cases in Kashgar, Xinjiang, China using the ARIMA-EGARCH model

Objective: To forecast the visceral leishmaniasis cases using autoregress integrated moving average (ARIMA) and hybrid ARIMA-EGARCH model, which offers a scientific basis to control visceral leishmaniasis spread in Kashgar Prefecture of Xinjiang, China. Methods: The data used in this paper are monthly visceral leishmaniasis cases in the Kashgar Prefecture of Xinjiang from 2004 to 2016. The sample data between 2004 and 2015 were used for the estimation to choose the best model and the sample data in 2016 were used for the forecast. Time series of visceral leishmaniasis started on 1 January 2004 and ended on 31 December 2016, consisting of 1 790 observations reported in Kashgar Prefecture. Results: For Xinjiang, the total number of reported cases were 2 187, the male-to-female ratio of cases was 1:1.42. Patients aged between 0 and 10 years accounted for 82.72% of all reported cases and the largest percentage of visceral leishmaniasis cases was detected among scattered children who accounted for 68.82%. The monthly incidences fitted by ARIMA (2, 1, 2) (1, 1, 1)12 model were consistent with the real data collected from 2004 to 2015. However, the predicted cases failed to comply with the observed case number; we then attempted to establish a hybrid ARIMA-EGARCH model to fit visceral leishmaniasis. Finally, the ARIMA (2, 1, 2) (1, 1, 1)12- EGARCH (1, 1) model showed a good estimation when dealing with volatility clustering in the data series. Conclusions: The combined model has been determined as the best prediction model with the root-mean-square error (RMSE) of 7.23% in the validation phase, which means that this model has high validity and rationality and can be used for short-term prediction of visceral leishmaniasis and could be applied to the prevention and control of the disease.
IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia—A Protector

Understanding of pathogenesis and protection mechanisms underlying influenza-Streptococcus pneumoniae co-infection may provide potential strategies for decreasing its high morbidity and mortality. Interleukin-6 (IL-6) is an important cytokine that acts to limit infection-related inflammation; however, its role in co-infected pneumonia remains unclear. Here we show that the clinically relevant co-infected mice displayed dramatically elevated IL-6 levels; which was also observed in patients with co-infected pneumonia. IL-6−/− mice presented with increased bacterial burden, early dissemination of bacteria to extrapulmonary sites accompanied by aggravated pulmonary lesions and high mortality when co-infection. This protective function of IL-6 is associated with cellular death and macrophage function. Importantly, therapeutic administration of recombinant IL-6 protein reduced cells death in BALF, and enhanced macrophage phagocytosis through increased MARCO expression. This protective immune mechanism furthers our understanding of the potential impact of immune components during infection and provides potential therapeutic avenues for influenza-Streptococcus pneumoniae co-infected pneumonia.