Miracle-dz/UniFAR-FTUs huggingface dataset:
The electromagnetic fields of a triaxial ellipsoid calculated by modal superposition

The electromagnetic fields and eigen-frequencies of triaxially ellipsoidal resonators have been calculated. The method used is modal superposition, based on the decomposition of the fields inside the resonator into a series expansion, with unknown coefficients, of the eigen-states of a spherical resonator. The coefficients and eigen-frequencies have then been calculated by minimizing the rms electric field at the resonator surface using software designed within MatLab®. Accuracies of parts in 1010 have been obtained for the eigen-frequencies, and the dependence of the calculations on the ellipsoidal eccentricities and the resonator modes has been analysed. The results are compared with those of Mehl (2009 Metrologia 46 554–9), who used a second-order approximation. The method of modal superposition has the potential for solving many similar problems in resonators of arbitrary shapes.
Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival

Simple Summary Heart transplantation is the gold standard in selected patients with end-stage heart failure. However, immune responses to the transplanted heart can lead to major complications and graft failure, limiting long-term survival. It has been shown that antibodies targeting the heart are elevated in end-stage heart failure patients and before transplantation of the donor heart. We aimed to determine whether elevated antibody levels before heart transplantation are associated with a poor outcome after transplantation. We measured four general subtypes of antibodies (IgM, IgG1, IgG2, IgG3) in the blood of patients just before the transplantation was performed. We observe that patients with higher levels of IgG1 and IgG2 antibodies tend to reject the transplanted heart more often compared to patients with lower levels of these antibodies. In addition, we observe that IgG1 and IgG2 levels in these patients remain elevated after transplantation. Together our data suggest that a more active adaptive, antibody-mediated, immune system can lead to graft-related complications in cardiac transplant patients. This implies that a subpopulation of heart transplant patients might benefit from expanded immunosuppressive therapy, which includes medications targeting antibody-producing cells. Abstract Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been found in end-stage heart failure (HF) patients prior to HTx. In this study, we aimed to determine whether increased circulating immunoglobulin levels prior to transplantation are associated with poor post-HTx survival. Pre-and post-HTx plasma samples of 36 cardiac transplant recipient patients were used to determine circulating immunoglobulin levels. In addition, epicardial tissue was collected to determine immunoglobulin deposition in cardiac tissue and assess signs and severity of graft rejection. High levels of IgG1 and IgG2 prior to HTx were associated with a shorter survival post-HTx. Immunoglobulin deposition in cardiac tissue was significantly elevated in patients with a survival of less than 3 years. Patients with high plasma IgG levels pre-HTx also had significantly higher plasma levels after HTx. Furthermore, high pre-HTX levels of IgG1 and IgG2 levels were also significantly increased in patients with inflammatory infiltrate in CAV lesions. Altogether the results of this proof-of-concept study suggest that an activated immune response prior to transplantation negatively affects graft survival.
Radiotherapeutic Strategies to Overcome Resistance of Breast Cancer Brain Metastases by Considering Immunogenic Aspects of Cancer Stem Cells

Simple Summary Modern radiotherapy offers several options for the treatment of brain metastases from breast cancer. The radioresistant subpopulation of cancer stem cells (CSCs) pose a particular challenge to a complete cure. This is attributable to the enhanced activation of molecular defense mechanisms that prevent cell death as a consequence of DNA damage. Another fundamental feature of CSCs is their evasion of the immune system. Combining inhibitors of both properties with irradiation may be an attractive option to advance existing therapies, and this is the subject of the data summarized here. Abstract Breast cancer is the most diagnosed cancer in women, and symptomatic brain metastases (BCBMs) occur in 15–20% of metastatic breast cancer cases. Despite technological advances in radiation therapy (RT), the prognosis of patients is limited. This has been attributed to radioresistant breast cancer stem cells (BCSCs), among other factors. The aim of this review article is to summarize the evidence of cancer-stem-cell-mediated radioresistance in brain metastases of breast cancer from radiobiologic and radiation oncologic perspectives to allow for the better interpretability of preclinical and clinical evidence and to facilitate its translation into new therapeutic strategies. To this end, the etiology of brain metastasis in breast cancer, its radiotherapeutic treatment options, resistance mechanisms in BCSCs, and effects of molecularly targeted therapies in combination with radiotherapy involving immune checkpoint inhibitors are described and classified. This is considered in the context of the central nervous system (CNS) as a particular metastatic niche involving the blood–brain barrier and the CNS immune system. The compilation of this existing knowledge serves to identify possible synergistic effects between systemic molecularly targeted therapies and ionizing radiation (IR) by considering both BCSCs’ relevant resistance mechanisms and effects on normal tissue of the CNS.
Oligomeric Proanthocyanidins Confer Cold Tolerance in Rice through Maintaining Energy Homeostasis

Oligomeric proanthocyanidins (OPCs) are abundant polyphenols found in foods and botanicals that benefit human health, but our understanding of the functions of OPCs in rice plants is limited, particularly under cold stress. Two rice genotypes, named Zhongzao39 (ZZ39) and its recombinant inbred line RIL82, were subjected to cold stress. More damage was caused to RIL82 by cold stress than to ZZ39 plants. Transcriptome analysis suggested that OPCs were involved in regulating cold tolerance in the two genotypes. A greater increase in OPCs content was detected in ZZ39 than in RIL82 plants under cold stress compared to their respective controls. Exogenous OPCs alleviated cold damage of rice plants by increasing antioxidant capacity. ATPase activity was higher and poly (ADP-ribose) polymerase (PARP) activity was lower under cold stress in ZZ39 than in RIL82 plants. Importantly, improvements in cold tolerance were observed in plants treated with the OPCs and 3-aminobenzamide (PARP inhibitor, 3ab) combination compared to the seedling plants treated with H2O, OPCs, or 3ab alone. Therefore, OPCs increased ATPase activity and inhibited PARP activity to provide sufficient energy for rice seedling plants to develop antioxidant capacity against cold stress.
The sun is observed to be a torsional oscillator with a period of 11 years

Twelve years of full-disk Mount Wilson velocity data have been analyzed to study horizontal east-west motions. A torsional wave pattern with alternating latitude zones of slow and fast rotation is found, after subtracting a differentially rotating frame. Amplitudes of the flow pattern average about 3 m/s. It requires about 22 years for zones to drift from the poles, where they originate, to the equator, where they disappear. The pattern is symmetric about the equator. The zones representing the next solar cycle (No. 22) are seen now at high solar latitudes. Solar active regions are formed in a latitude strip centered on the boundary of fast- and slow-velocity zones. This pattern evidently represents a deep-seated circulation pattern and is the first evidence of the association of mass motions with large-scale characteristics of the solar activity cycle.
Instability and Plastic Flow of Soils. II: Analytical Investigation

Based on the condition that a stable material is able to sustain a small perturbation in load, the stability of an elasto‐plastic granular material with non‐associated flow is analyzed, and necessary conditions for mechanical stability of saturated and partly saturated specimens are proposed. Using experimental data obtained from drained tests, the local yield and plastic potential surfaces are established. Their position shows the existence of a wedge where plastic loading occurs, while the second increment of plastic work is negative. Under drained conditions where strains are free to develop without restraint, instabilities cannot develop, and the material will be stable, even when Drucker's postulate is violated. For an elasto‐plastic material under undrained conditions with full or partial saturation, the proposed conditions show that instability may occur when the yield surface opens in the outward direction of the hydrostatic axis, and the material tends to compress. The experimental data supported.
Effect of active layer thickness on bias stress effect in pentacene thin-film transistors

The bias stress effect in pentacene thin-film transistors is characterized for different active layer thicknesses. We show that the shift in threshold voltage under applied bias is accelerated as the pentacene semiconductor layer thickness is increased from 10to80nm, and that this trend is not correlated with current, initial threshold voltage, or turn-on voltage. This study sheds light on the role of active material above the conductive channel in thin-film devices and describes effects that are important to consider when optimizing the structure of organic thin-film transistors.
Inlet condition generation for spatially developing turbulent boundary layers via multiscale similarity

A multiscale approach for simulating realistic turbulent momentum information at the entrance of a computational domain, which considers a spatially evolving turbulent boundary layer, is presented for incompressible flows. The new method is based on the rescaling–recycling method proposed by T. Lund, X. Wu, and K. Squires [Generation of turbulent inflow data for spatially developing boundary layer simulations, J. Comput. Phys. 140 (1998), pp. 233–258] and the core idea consists of predicting the inflow turbulent velocity data from the solution downstream. Direct Numerical Simulations (DNS) are performed in zero pressure gradient flows (ZPG) at low and high Reynolds numbers. The range of higher Reynolds numbers, Re θ, is around 1940–2300 based on the freestream velocity and momentum thickness. This might represent, to the best of our knowledge, the flat plate predictions at the highest Reynolds number available. The predicted skin friction coefficients, boundary layer parameters, and turbulence statistics, such as Reynolds stresses, show fairly good agreement with empirical correlations, experimental, and other numerical data from the literature. Furthermore, different scales for the inner and outer flows of the boundary layer are considered, which makes the current multiscale approach suitable for pressure gradient (PG) flows. This is indeed the major contribution of the current research and an improvement with respect to the single-scaling methodology, originally introduced by Lund et al. The simulation of a spatially evolving boundary layer under an adverse pressure gradient (APG) is also treated and validated at the end of the paper.
INVERSE CASCADE IN IMBALANCED ELECTRON MAGNETOHYDRODYNAMIC TURBULENCE

Electron magnetohydrodynamics (EMHD) provides a fluid-like description of small-scale magnetized plasmas. Balanced EMHD turbulence has been studied for a long time. However, driven imbalanced EMHD turbulence, in which waves moving in one direction (dominant waves) have higher amplitudes than waves moving in the other direction (sub-dominant waves), has not been well studied. In this paper, we numerically study driven three-dimensional imbalanced weak EMHD turbulence. We find the following results. First, in driven imbalanced EMHD turbulence, we clearly observe inverse cascade of magnetic helicity, as well as magnetic energy. This is because magnetic helicity is a conserved quantity and non-zero magnetic helicity is injected into the system in driven imbalanced EMHD turbulence. Second, the magnetic energy spectrum of the dominant waves on scales larger than the energy injection scale does not show a single power-law spectrum, which indicates that the inverse cascade is not a self-similar process. The peak of the spectrum roughly follows a k−3/2 spectrum, which can be explained by a Kolmogorov-type argument for weak turbulence. Third, a small amount of sub-dominant waves is induced by the dominant waves on large scales and the ratio of helicity densities of the dominant and the sub-dominant waves on large scales seems to converge to a certain value.
The Protective Role of Salmonella Typhimurium-Whole Sonicated Killed Antigen and Syzygium aromaticum Extract on the Histopathological Changes Against Its Infection in Rabbits

This research aimed to evaluate the protective ability of Syzygium aromaticum methanolic extract against Salmonella Typhimurium infection in rabbits. Three groups of eight rabbits were given the following: The first group was subcutaneously given SalmonellaTyphimurium-whole sonicated killed antigen (ST-WSKAg); the second group was orally given S. aromaticum extract as well as KWCSAg-ST subcutaneously; the third group was left as positive control group. The rabbit groups were orally challenged by 9×108 CFU/mLSalmonella Typhimurium then the animals were sacrificed 10 days postchallenge for histopathological study. Intestine, liver, kidney, and spleen were studied for pathological changes. The results showed that the second group had the least histopathological changes with mild inflammation and cellular infiltration of inflammatory cells, as well as low amount of vacuolation. The ST-WSKAg group showed multifocal aggregation of inflammatory cells and inflammation of all organs studied, as well as slight interstitial edema with few cellular infiltration and cystic tubular dilation of neighboring tubules in kidney. The positive control group showed the most extensive signs of destruction, severe inflammatory cells infiltration, as well as existence of live bacterium in tissue. In conclusion, Syzygium aromaticum extract showed to give a suitable protective ability against inflammation and destruction of virulent Salmonella Typhimurium infection in comparison to both of ST-WSKAg and positive control groups
Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Background Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells. Quercetin is a flavonoid presents in some traditional Chinese medicine, plants, and fruits. Its protective effects in several gastrointestinal tumors have been demonstrated, but its effects on bacterial enteritis and pyroptosis-related diseases have rarely been studied. Objective This study aimed to evaluate the effect of quercetin on bacterial enteritis and pyroptosis. Design In vitro experiments were performed using rat intestinal microvascular endothelial cells divided into seven groups: control group (no treatment), model group (10 μg/mL lipopolysaccharide (LPS)+1 mM adenosine triphosphate [ATP]), LPS group (10 μg/mL LPS), ATP group (1 mM ATP), and treatment groups (10 μg/mL LPS+1 mM ATP and 5, 10, and 20 μM quercetin). The expression of pyroptosis-associated proteins, inflammatory factors, tight junction proteins, and the percentage of late apoptotic and necrotic cells were measured. In vivo analysis was performed using specific pathogen-free Kunming mice pretreated with quercetin and the water extract of Cacumen Platycladi for 2 weeks followed by 6 mg/kg LPS on day 15. Inflammation in the blood and intestinal pathological changes were evaluated. Results Quercetin used in vitro significantly reduced the expression of Toll-like receptor 4 (TLR4), NOD-like receptor 3 (NLRP3), caspase-1, gasdermin D, interleukin (IL)-1β, IL-18, IL-6, and tumor necrosis factor-α. It also inhibited phosphorylation of nuclear factor-kappa B (NF-κB) p65 and increased cell migration and the expression of zonula occludens 1 and claudins, while reduced the number of late apoptotic cells. The in vivo results showed that Cacumen Platycladi and quercetin significantly reduced inflammation, protected the structure of the colon and cecum, and prevent fecal occult blood induced by LPS. Conclusions These findings suggested the ability of quercetin to reduce inflammation induced by LPS and pyroptosis through TLR4/NF-κB/NLRP3 pathway.
A retrospective study of emergent traumatic dental injuries in permanent teeth in Xi’an, China

Traumatic dental injury is one of the common injuries seen in the emergency department. To determine the distribution features of emergency traumatic dental injuries in Xi’an, China, data from the medical records of 623 patients (aged 6–78 years) were evaluated and analyzed according to age, gender, etiology, factors predisposing teeth to injury, and types of teeth traumatized. The patient records of 397 males (63.7%) and 226 females (36.3%), with a 1.8:1 male-to-female ratio, were included. The total number of traumatized teeth was 1475. The highest frequency of dental trauma was found in the 19- to 30-year age group (30.7%). The greatest frequency of dental trauma injuries was in May (13%). Over one-third of patients with traumatic injuries to permanent teeth (n = 218, 35%) injured 2 permanent teeth. The most commonly affected teeth were the maxillary central incisors (59.3%). The most common type of trauma was concussion (20.4%). There was statistically significant difference among the type composition ratio of age groups (P < .05). The most common causes of dental trauma were falls (50.2%). There was statistically significant difference among the etiological composition ratio of age groups (P < .05). Combined injuries were present in 120 teeth in 103 patients (16.5%). The epidemiological characteristics of dental trauma in Xi’an shows that the occurrence of dental trauma is closely related to the age, sex, time, type of injury, and cause of injury. There exists cross-correlation among the epidemiological factors. The most common type of trauma is concussion and the most common cause of dental trauma is fall. High incidence of combined injuries needs extra attention.
Halal production of omega 3 enriched eggs on the farm Pećigrad, B&H

The aim of this research is to develop a functional food and halal Omega 3 eggs by dietary manipulation of laying hens as well as to investigate the influence of nutrient composition on egg yolk content of PUFAs. The research was conducted on the farm Pećigrad, Velika Kladuša, which has 21,162 laying hens, with an egg production rate of 70%. Laying hens were fed with halal and NON GMO feed mixtures from three suppliers. Omega 3 eggs contained 318 mg of Omega 3 PUFAs, which is 6 times more than the standard eggs. The n-6:n-3 PUFAs ratio was 18.4:1.9=9.9 in egg yolks of laying hens fed with standard feed mixture, while in egg yolks produced by laying hens fed with feed mixture enriched with flaxseed this ratio was 17.8:5.3=3.4. Consumption of eggs with the latter n-6:n-3 ratio can prevent cardiovascular diseases and provides the intake of RDA of Omega 3 FAs. Traceability and established HrCCP in the chain of suppliers, in processes of primary and industrial production, application of good practices, sustainable development resulted in halal products with additional functional properties.
Evaluation of skin natural change function in split-thickness skin graft

Treatment for severe burns has improved rapidly in the last 20 years. Nowadays, patients can survive with burns covering up to approximately 90% of the body, although they often face permanent physical impairment. This type of research is a literature review. A literature review was conducted to gather information regarding the evaluation of skin natural change function in the split-thickness skin graft. This research is a type of review article that aims to obtain information about acne based on bio-markers. Source of data used secondary sources. The method of data collection through collecting data was from research articles taken within the last five years. Skin grafting remains an essential step on the reconstructive surgeon ladder. Meanwhile, the basic premise has remained similar results over the years. New techniques and devices have contributed to significantly improved functional and aesthetic results. Advances in the production of skin substitutes have provided better options to treat patients and will continue to be an essential and dynamic component of this field in the future.
Citrus β-carotene hydroxylase 2 (BCH2) participates in xanthophyll synthesis by catalyzing the hydroxylation of β-carotene and compensates for BCH1 in citrus carotenoid metabolism

Abstract As an essential horticultural crop, Citrus has carotenoid diversity, which affects its aesthetic and nutritional values. β,β-Xanthophylls are the primary carotenoids accumulated in citrus fruits, and non-heme di-iron carotene hydroxylase (BCH) enzymes are mainly responsible for β,β-xanthophyll synthesis. Previous studies have focused on the hydroxylation of BCH1, but the role of its paralogous gene in citrus, BCH2, remains largely unknown. In this study, we revealed the β-hydroxylation activity of citrus BCH2 (CsBCH2) for the first time through the functional complementation assay using Escherichia coli, although CsBCH2 exhibited a lower activity in hydroxylating β-carotene into β-cryptoxanthin than citrus BCH1 (CsBCH1). Our results showed that overexpression of CsBCH2 in citrus callus increased xanthophyll proportion and plastoglobule size with feedback regulation of carotenogenic gene expression. This study revealed the distinct expression patterns and functional characteristics of two paralogous genes, CsBCH1 and CsBCH2, and illustrated the backup compensatory role of CsBCH2 for CsBCH1 in citrus xanthophyll biosynthesis. The independent function of CsBCH2 and its cooperative function with CsBCH1 in β-cryptoxanthin biosynthesis suggested the potential of CsBCH2 to be employed for expanding the synthetic biology toolkit in carotenoid engineering.
Two‐scale shear band evolution by local partition of unity

We introduce a methodology to model shear band evolution in the quasi‐static regime using the extended finite element method. We enrich the finite element polynomial displacement field with a fine scale function, which models the high displacement gradient in the shear band. For this purpose we use a local partition of unity and a parameterized displacement enrichment based on closed form solutions for one‐dimensional shear bands. A stabilized consistent penalty method is used to circumvent locking in the regularized elasto‐viscoplastic plane‐strain regime and to guarantee element stability. The loss of stability of the boundary value problem is used as an indicator of shear band initiation point and direction. Shear band development examples are shown, illustrating the capabilities of the method to track shear band evolution and strains as high as 1000%. Copyright © 2005 John Wiley & Sons, Ltd.