Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Urban Rail Transit Epidemic Prevention Measures on Passengers’ Safety Perception

In 2020, COVID-19 triggered concern about the safety of public transport. To meet passengers’ expectations regarding safety, the public transport department has stepped up its pandemic prevention services. Some prevention services require passengers to follow mandatory requirements. However, whether and to what extent these requirements affect passenger satisfaction with public transportation services remains unclear. This study aims to construct an integrated framework to explore the direct and indirect relationships between four constructs (regular services quality, pandemic prevention service, psychological distance, and safety perception) and passengers’ satisfaction in the context of urban rail transit services. Based on survey data collected from 500 passengers on the Shanghai Metro, this paper examines the relationships between routine service, pandemic prevention measures, safety perceptions, and satisfaction with the service. The results from the structural equation model indicate that routine service (0.608), pandemic prevention measures (0.56), and safety perception (0.05) have positive effects on passenger satisfaction. Psychological distance negatively impacts safety perception (−0.949) and has indirect effects on passenger satisfaction. Further, in order to identify the service improvements that public transportation departments should focus on, we use the three-factor theory to identify the services that should be improved: Basic factors, such as “punctual arrival of metros”, “treatment of harmful garbage”, “increasing frequency of platform disinfection”, and “measurement of station temperature” should be treated as the first priority. As the second improvement priority, “the planning of metro stations can accommodate my travel scope” can be considered. Last, public transportation departments can enhance the exciting factor by installing “metro entrance signs” when resources are available.
Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea: A Cross-Sectional Study Based on 2019–2020 Korea National Health and Nutrition Examination Survey Data

Diabetes mellitus is a chronic disease with high economic and social burdens. This study aimed to determine the risk factors of microalbuminuria among patients with type 2 diabetes mellitus. Microalbuminuria is predictive of early-stage renal complications and subsequent progression to renal dysfunction. We collected data on type 2 diabetes patients who participated in the 2019–2020 Korea National Health and Nutrition Examination Survey. The risk factors for microalbuminuria among patients with type 2 diabetes were analyzed using logistic regression. As a result, the odds ratios were 1.036 (95% confidence interval (CI) = 1.019–1.053, p < 0.001) for systolic blood pressure, 0.966 (95% CI = 0.941–0.989, p = 0.007) for high-density lipoprotein cholesterol level, 1.008 (95% CI = 1.002–1.014, p = 0.015) for fasting blood sugar level, and 0.855 (95% CI = 0.729–0.998, p = 0.043) for hemoglobin level. A significant strength of this study is the identification of low hemoglobin level (i.e., anemia) as a risk factor for microalbuminuria in patients with type 2 diabetes. This finding implies that the early detection and management of microalbuminuria can prevent the development of diabetic nephropathy.
Influence of Different Ratios of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus on Fermentation Characteristics of Yogurt

Lactic acid bacteria (LAB) are industrially important bacteria that are widely used in the fermented food industry, especially in the manufacture of yogurt. The fermentation characteristics of LAB are an important factor affecting the physicochemical properties of yogurts. Here, different ratios of L. delbrueckii subsp. bulgaricus IMAU20312 and S. thermophilus IMAU80809 were compared with a commercial starter JD (control) for their effects on viable cell counts, pH values, titratable acidity (TA), viscosity and water holding capacity (WHC) of milk during fermentation. Sensory evaluation and flavour profiles were also determined at the end of fermentation. All samples had a viable cell count above 5.59 × 107 CFU/mL at the end of fermentation, and a significant increase in TA and decrease in pH were observed. Viscosity, WHC and the sensory evaluation results of one treatment ratio (A3) were closer to the commercial starter control than the others. A total of 63 volatile flavour compounds and 10 odour-active (OAVs) compounds were detected in all treatment ratios and the control according to the results from solid-phase micro-extraction–gas chromatography–mass spectrometry (SPME–GC–MS). Principal components analysis (PCA) also indicated that the flavour characteristics of the A3 treatment ratio were closer to the control. These results help us understand how the fermentation characteristics of yogurts are affected by the ratio of L. delbrueckii subsp. bulgaricus to S. thermophilus in starter cultures; this is useful for the development of value-added fermented dairy products.
Tissue characterization of the prostate using Kohonen-maps

Although transrectal ultrasound is one of the most important tools in the diagnosis and early detection of prostatic cancer, the sensitivity and specificity of the standard sonographic methods are still insufficient. We describe a method which provides the clinician with additional information in the form of color-coded tissue characterization images based on the learning vector quantization (LVQ) algorithm proposed by Kohonen
Turbulence integral length and footprint dimension with reference to experimental data measured over maize cultivation in Po Valley, Italy

The atmospheric turbulence in the planetary boundary layer (PBL) governs the mass and energy exchange over the soil-vegetation-atmosphere system. Micrometeorological stations based on the eddy-covariance technique have been recently developed for the assessment of latent and sensible heat fluxes through high frequency measurements of the fluctuating component of wind velocity, temperature and air water content in the PBL. Correct interpretation of such measurements requires assessment of the actual source area (footprint) contributing to the eddy fluxes (latent and sensible heat). Many different approaches have been developed to estimate the source area function but there is no general consensus on the accuracy and applicability of these methods. The objective of this work is to demonstrate the existence of a relationship between the representative source area for eddy covariance measurements, and the large eddies responsible for the transport of turbulent kinetic energy (TKE). Moreover, the energy balance closure was used to analyze the possible effects of the different lengths of the source area on the heat fluxes. A series of measurements were carried out in a micrometeorological eddy covariance station located in a maize field in Landriano in Po Valley (PV), Italy. The results show that the dimension of the large eddies is tightly bound to the footprint size, leading to a new approach to study the eddy covariance measure based on the assessment of the turbulence scale.
Precision polarization measurements of atoms in a far-off-resonance optical dipole trap

Precision measurement of atomic and nuclear polarization is an essential step for beta-asymmetry measurement of radioactive atoms. In this paper, we report the polarization measurement of Rb atoms in an yttrium-aluminum-garnet (YAG) far-off-resonance optical dipole trap. We have prepared a cold cloud of polarized Rb atoms in the YAG dipole trap by optical pumping and achieved an initial nuclear polarization of up to 97.2(5)%. The initial atom distribution in different Zeeman levels is measured by using a combination of microwave excitation, laser pushing, and atomic retrap techniques. The nuclear-spin polarization is further purified to 99.2(2)% in 10 s and maintained above 99% because the two-body collision loss rate between atoms in mixed spin states is greater than the one-body trap loss rate. Systematic effects on the nuclear polarization, including the off-resonance Raman scattering, magnetic field gradient, and background gas collisions, are discussed.
Simulation of a compositional model for multiphase flow in porous media

In this article, we consider the simulation of a compositional model for three‐dimensional, three‐phase, multicomponent flow in a porous medium. This model consists of Darcy's law for volumetric flow velocities, mass conservation for hydrocarbon components, thermodynamic equilibrium for mass interchange between phases, and an equation of state for saturations. A discretization scheme based on the block‐centered finite difference method for pressures and compositions is developed. Numerical results are reported for the benchmark problem of the third comparative solution project (CSP) organized by the society of petroleum engineers (SPE). © 2004 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2005.
On designing observers for time-delay systems with non-linear disturbances

In this paper, the observer design problem is studied for a class of time-delay non-linear systems. The system under consideration is subject to delayed state and non-linear disturbances. The time-delay is allowed to be time-varying, and the non-linearities are assumed to satisfy global Lipschitz conditions. The problem addressed is the design of state observers such that, for the admissible time-delay as well as non-linear disturbances, the dynamics of the observation error is globally exponentially stable. An effective algebraic matrix inequality approach is developed to solve the non-linear observer design problem. Specifically, some conditions for the existence of the desired observers are derived, and an explicit expression of desired observers is given in terms of some free parameters. A simulation example is included to illustrate the practical applicability of the proposed theory.
Application of smoothing techniques to solve the cooling and heating residential load aggregation problem

The main objective of this paper is to obtain the duty‐cycle probability forecast functions of cooling and heating aggregated residential loads. The method consists of three steps: first, the single loads are modelled using systems of stochastic differential equations based on perturbed physical models; second, intensive numerical simulation of the stochastic system solutions is performed, allowing several parameters to vary randomly; and third, smoothing techniques based on kernel estimates are applied to the results to derive non‐parametric estimators, comparing several kernel functions. The use of these dynamical models also allows us to forecast the indoor temperature evolution under any performance conditions. Thus, the same smoothing techniques provide the indoor temperature probability forecast function for a load group. These techniques have been used with homogeneous and non‐homogeneous device groups. Its main application is focused on assessing Direct Load Control programs, by means of comparing natural and forced duty‐cycles of aggregated appliances, as well as knowing the modifications in customer comfort levels, which can be directly deduced from the probability profiles. Finally, simulation results which illustrate the model suitability for demand side – bidding – aggregators in new deregulated markets are presented.
Dexmedetomidine versus fentanyl effect as adjuvants to bupivacaine on post spinal urinary retention in knee joint arthroscopic surgeries

ABSTRACT Background Ambulatory knee surgeries are increasing in frequency, however post spinal urinary retention can represent a hazardous post-operative issue to patients. The aim of this study was to assess the impact of intrathecally injected 5 µg dexmedetomidine, or 25 µg fentanyl as adjuvants to bupivacaine in low dose spinal anesthesia for unilateral arthroscopic knee surgeries, on the incidence of post-operative urinary retention (POUR), the duration of sensory and motor blocks, time to micturition, and the number of patients who needed an indwelling (Foley’s) catheter. Methods Seventy patients, American Society of Anesthesiologists (ASA) physical status I or II, from 21 to 50 years old, were randomly divided into two equal groups: the Bupivacaine-Dexmedetomidine group (BD) patients and the Bupivacaine-Fentanyl group (BF) patients. Results The incidence of POUR was statistically non-significant less in the BD group patients, than in the BF group patients. The duration of sensory and motor blocks, as well as the time to micturition, was comparable between patients in the two groups. No patient in either group required insertion of an indwelling urinary catheter at the sixth post-operative hour. Conclusion In unilateral arthroscopic knee surgeries, the addition of dexmedetomidine to low-dose spinal anesthesia decreased the clinical incidence of POUR compared to the addition of fentanyl.
Enhanced Targeted Delivery of Minocycline via Transferrin Conjugated Albumin Nanoparticle Improves Neuroprotection in a Blast Traumatic Brain Injury Model

Traumatic brain injury (TBI) is a major source of death and disability worldwide as a result of motor vehicle accidents, falls, attacks and bomb explosions. Currently, there are no FDA-approved drugs to treat TBI patients predominantly because of a lack of appropriate methods to deliver drugs to the brain for therapeutic effect. Existing clinical and pre-clinical studies have shown that minocycline’s neuroprotective effects either through high plasma protein binding or an increased dosage requirement have resulted in neurotoxicity. In this study, we focus on the formulation, characterization, in vivo biodistribution, behavioral improvements, neuroprotective effect and toxicity of transferrin receptor-targeted (tf) conjugated minocycline loaded albumin nanoparticles in a blast-induced TBI model. A novel tf conjugated minocycline encapsulated albumin nanoparticle was developed, characterized and quantified using a validated HPLC method as well as other various analytical methods. The results of the nanoformulation showed small, narrow hydrodynamic size distributions, with high entrapment, loading efficiencies and sustained release profiles. Furthermore, the nanoparticle administered at minimal doses in a rat model of blast TBI was able to cross the blood–brain barrier, enhanced nanoparticle accumulation in the brain, improved behavioral outcomes, neuroprotection, and reduced toxicity compared to free minocycline. Hence, tf conjugated minocycline loaded nanoparticle elicits a neuroprotective effect and can thus offer a potential therapeutic effect.
Weak lower semicontinuity of polyconvex integrals

Synopsis Multiple integrals with polyconvex integrands are studied on the class of all sense-preserving diffeomorphisms from W1,p(Ω, Rn) where Ω is an open subset of Rn. They are proved to be sequentially weakly lower semicontinuous if 1 < p = n –1. An example is presented showing that a similar result is not valid if p
Translational advances in the treatment of childhood acute lymphoblastic leukemia: narrative review of current and emerging molecular and immunotherapies

Background and Objective Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy of lymphoid origin in children. The prognosis for newly diagnosed ALL in the pediatric population is generally favorable, with a 5-year overall survival rate of more than 90%. Though conventional therapy has led to meaningful improvements in cure rates for new-onset pediatric ALL, one-third of patients still experience a relapse or refractory disease, contributing to a significant cause of pediatric cancer-related mortality. Methods An extensive literature review was undertaken via various databases of medical literature, focusing on both results of larger clinical trials, but also with evaluation of recent abstract publications at large hematologic conferences. Key Content and Findings Remission is achievable in most of these patients by re-induction with currently available therapies, but the long-term overall survival rate is deemed suboptimal and remains a therapeutic challenge. As part of never-ceasing efforts to improve pediatric ALL outcomes, newer modalities, including targeted molecular therapies as well as immunotherapy, and chimeric antigen receptor (CAR) T-cell therapy, are currently being employed to increase treatment effectiveness as well as lessen the side effects from conventional chemotherapy. These approaches explore the use of early genome-based disease characterization and medications developed against actionable molecular targets. Conclusions Additional clinical research is nonetheless required to learn more about the potentially harmful effects of targeted therapies and investigate the possibility of these agents replacing or decreasing the use of conventional chemotherapy in treating pediatric ALL.
Dexmedetomidine only regimen for long-term sedation is associated with reduced vasopressor requirements in septic shock patients: A retrospective cohort study from MIMIC-IV database

Background Previous studies have shown that dexmedetomidine (DEX) may be associated with reduced vasopressor requirements in septic shock patients, however, long-term DEX-only sedation in reducing vasopressor requirements is still controversial. Methods A retrospective study was conducted among patients with septic shock on mechanical ventilation using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The primary outcome was the ratio of norepinephrine equivalent dose to mean arterial pressure (NEq/MAP) in the first 72 h after DEX or other sedatives for sedation. The secondary outcomes were key organ function parameters, 28-day mortality, and 90-day mortality. Univariate, propensity score matching (PSM), and generalized linear mixed model (GLMM) analyses were performed. Results DEX was associated with decreased NEq/MAP in the first 72 h (difference = 0.05, 95% CI = –0.02–0.08, p = 0.002) after adjusting for confounders in the GLMM analysis. The DEX group was also associated with a lower heart rate, cardiac output (CO), lactate level, aspartate transaminase (AST) level, and higher PaO2/FiO2 ratio (p < 0.0125). Moreover, DEX only sedation was associated with reduced 90-day mortality (OR = 0.60, 95% CI = 0.37–0.94, p = 0.030). Conclusion DEX may be associated with decreased vasopressor requirements, improved AST and PaO2/FiO2 levels, and reduced 90-day mortality in patients with septic shock, which warrants further study.
The Effect of Supplementation Using a Mixture of Fish Oil and Linseed on the Level of Immunomodulatory Components in Bovine Colostrum

The aim of this study was to determine the effect of supplementing rations, with a mixture of fish oil and linseed, on the level of immunomodulatory components in colostrum. Twenty multiparous cows, that were three weeks before scheduled calving, had a body condition of 3–3.5, and had not been diagnosed with multiple pregnancies, were qualified for the experiment. The cows were divided into two groups: experimental (FOL) (n = 10) and control (CTL) (n = 10). The CTL group were individually given the standard food ration for dry cows for about 21 days before calving, while the FOL group received food rations that were enriched with 150 g of fish oil and 250 g of linseed (golden variety). Colostrum samples for testing were taken twice a day on the first and second days of lactation, and then once a day from the third to the fifth day of lactation. The experiment showed that the applied supplementation had an impact, in the form of increasing the fat, protein, IgG, IgA, IgM, vitamin A, C22:6 n-3 (DHA), and C18:2 cis9 trans11 (CLA) contents in colostrum; however, the C18: 2 n-6 (LA) and C20:4 n-6 (AA) contents decreased. Due to the lower quality of colostrum found in high-yield cows, and therefore in the Holstein–Friesian breed, it is possible to improve the quality by, among other things, introducing nutritional modifications during the second stage of the dry period.
Relationships between the Content of Micro- and Macroelements in Animal Samples and Diseases of Different Etiologies

Simple Summary Macro- and microelements (MMEs), simply called as “minerals”, are essential biogenic elements for animals and humans. These two MME groups are very important and differ only in that the first group) macroelements (Ca, P, K, Na, S, Cl, Mg) are containing in concentrations more than 0.01% and required by the body in doses from a few grams to several milligrams per day, whereas the second group) microelements (Fe, Zn, Cu, Mo, Mn, I, etc.) – from ten to hundred times less. MMEs are distributing in all the tissues and organs, playing the key roles in their functions. The numerous enzymes (as protein biocatalysts) are using MMEs as essential elements (“cofactors” or “coenzymes”) for metabolic reactions in all cells. Some researchers, including us, are mentioning toxic heavy metals (Arsenic, Cadmium, Lead, Mercury, etc.) in the MME general concept, but as the third special group, because these metals are quite dangerous and have the ability to cause various diseases (cardiovascular, metabolic, nervous, oncological diseases, etc.). It is important to monitor the MME-status of the animals regularly by using non-invasive biological materials (such as hair, fur, etc.). Abstract Many of the micro- and macro-elements (MMEs) required by the body are found in environmental objects in concentrations different from their original concentration that can lead to dangerous animal diseases (“microelementoses”). The aim was to study the features of MME (accumulating in wild and exotic animals) in connection with particular diseases. The work using 67 mammal species from four Russian zoological institutions was completed in 2022. Studies of 820 cleaned and defatted samples (hair, fur, etc.) after “wet-acid-ashing” on an electric stove and in a muffle furnace were performed using a Kvant-2A atomic absorption spectrometer. The content of zinc, copper, iron, cadmium, lead, and arsenic was assessed. The level of MME accumulation in the animal body contributes not only to the MME status and the development of various concomitant diseases, but the condition itself can occur by intake of a number of micronutrients and/or drugs. Particular correlations between the accumulation of Zn and skin, oncological diseases, Cu—musculoskeletal, cardiovascular diseases, Fe—oncological diseases, Pb—metabolic, nervous, oncological diseases, and Cd—cardiovascular diseases were established. Therefore, monitoring of the MME status of the organism must be carried out regularly (optimally once every 6 months).
Effect of Sodium-Glucose Cotransporter 2 Inhibitors on Clinical and Laboratory Variables in Heart Failure Patients with Reduced Left Ventricular Ejection Fraction in a Latin American Hospital: A Retrospective Study

Heart failure (HF) is a syndrome suffered by more than 26 million people worldwide. SGLT2 inhibitors are drugs that have been shown to positively affect the management of HF patients, regardless of their diabetes status. A retrospective observational study was conducted on heart failure patients with reduced ejection fraction (HFrEF) enrolled at the HF clinic, who were on SGLT2 inhibitors. For these patients, baseline and follow-up data were collected and analyzed over time. Changes over time were quantified and statistical analysis was conducted to validate whether the changes were significant. After the screening of all the HF program patients, 24 met the inclusion criteria, with an average age of 68 years. Through the study, it was possible to find a statistically significant difference in the values of NT-ProBNP before and after adding a SGLT2 inhibitor in 14 patients (p = 0.0214). In addition, there was an improvement in the NYHA functional scale of 71% and no significant change in renal function or other laboratory values. Based on the studied parameters and throughout the clinical changes during the follow-up period, it was possible to establish an improvement in HFrEF patients on SGLT2 inhibitors as part of their therapy.