Miracle-dz/UniFAR-FTUs huggingface dataset:
Systematic two-dimensional radiation-hydrodynamic simulations of super-Eddington accretion flow and outflow: Comparison with the slim disk model

To what extent can the one-dimensional slim disk model reproduce the multi-dimensional results of global radiation-hydrodynamic simulations of super-Eddington accretion? With this question in mind, we perform systematic simulation study of accretion flow onto a non-spinning black hole for a variety of black hole masses of $(10 - 10^7) M_{\odot}$ and mass accretion rates of $(1.4 \times 10^2 - 5.6 \times 10^3)L_{\rm Edd}/c^2$ (with $L_{\rm Edd}$ and $c$ being the Eddington luminosity and speed of light). In order to adequately resolve large-scale outflow structure, we extensively expand a simulation box to cover the space of $3000 r_{\rm S}$ (with $r_{\rm S}$ being the Schwarzschild radius), larger than those in most previous studies, so that we can put relatively large angular momentum to the gas injected from the outer simulation boundary. The adopted Keplerian radius, at which the centrifugal force balances with the gravitational force, is $r_{\rm K}=300 r_{\rm S}$. The injected mass first falls and is accumulated at around this radius and then slowly accretes towards the central black hole via viscosity. We simulate such accretion processes, taking inverse and bulk Compton scattering into account. The simulated accretion flow is in a quasi-steady state inside $r_{\rm qss}\sim 200 r_{\rm S}$. Within this radius the flow properties are, as a whole, in good agreement with those described by the slim disk model except that the radial density profile of the underlying disk is much flatter, $\rho\propto r^{-0.73}$ (cf. $\rho\propto r^{-3/2}$ in the slim disk model), due probably to efficient convection. We find very weak outflow from inside $r\sim 200 r_{\rm S}$ unlike the past studies.
A Within-Person Test of the Impact of Extended Solitary Confinement on Mental Health Functioning and Service Use

There is conflicting evidence on whether people, particularly those with preexisting mental health problems, have worse mental health during and after extended solitary confinement (SC) stays. Using administrative data on 843 men, we examined within-person changes in mental health functioning and service use surrounding long-term stays in SC in Florida correctional facilities. During these stays, service use increased, psychological functioning improved, and mental health crises declined. The former two associations persisted during step-down placements in lower levels of restrictive housing and during the month following restrictive housing stays. The same associations were observed among men with and without serious mental illnesses, though they were more muted among the former group. The increased provision of treatment might prevent mental health problems from developing or worsening among those held in long-term SC and might even improve psychological functioning relative to when the same people are in general population housing.
The Influence of Planet Nine on the Orbits of Distant TNOs: The Case for a Low-perihelion Planet

The hypothesis of an additional planet in the outer solar system has gained new support as a result of the confinement noted in the angular orbital elements of distant trans-Neptunian objects. Orbital parameters proposed for the external perturber suggest semimajor axes between 500 and 1000 au, perihelion distances between 200 and 400 au for masses between 10 and 20 M⊕. In this paper, we study the possibility that lower perihelion distances for the additional planet can lead to angular confinements as observed in the population of objects with semimajor axes greater than 250 au and perihelion distances higher than 40 au. We performed numerical integrations of a set of particles subjected to the influence of the Sun, the known giant planets, and the putative perturber during the age of the solar system and compared our outputs with the observed population through a statistical analysis. Our investigations showed that lower perihelion distances from the outer planet usually lead to more substantial confinements than higher ones, while retaining the Classical Kuiper Belt as well as the ratio of the number of detached with perihelion distances higher than 42 au to scattering objects in the range of semimajor axes from 100 to 200 au.
What Drives Visitors’ Use of Bins in Urban Parks? An Application of the Stimulus-Organism-Response Model

Littering by visitors has led to severe challenges for rubbish collection in urban parks. One way to solve this problem is to encourage visitors to put rubbish in the bin. The purpose of this study is to explore the mechanism that drives people’s use of bins in urban parks. The theoretical model of stimulus-organism-response is used to test the influence of stimuli (personal and social norms) on people’s psychology (facilitators and inhibitors), thereby producing responses (the use of bins). In this study, we used a purposeful sampling method. Overall, 400 questionnaires were distributed, and 356 valid questionnaires were collected from visitors to the Shanghai City Park in China. The data were analysed using structural equations. The results show that personal and social norms have a significant impact on visitors’ internal psychological state (facilitators and inhibitors). More specifically, personal and social norms are positively correlated with facilitators and negatively correlated with inhibitors. They have a significant positive impact on people’s use of bins. We also found that facilitators and inhibitors partially mediate the relationship between norms and behaviours. The study suggests park managers should introduce various measures to influence people’s personal norms and cultivate people’s awareness of their obligation, responsibility, and commitment to the environment, and managers should also show visitors the consequences of not properly disposing of their rubbish as well as place more rubbish bins in key areas.
Human Papillomavirus Oncoproteins Confer Sensitivity to Cisplatin by Interfering with Epidermal Growth Factor Receptor Nuclear Trafficking Related to More Favorable Clinical Survival Outcomes in Non-Small Cell Lung Cancer

Simple Summary Lung cancer is the leading cause of cancer death in the world. Identifying prognostic factors is crucial to improve the survival time of those with lung cancer. Our previous studies have reported that human papillomavirus (HPV) infections and epidermal growth factor receptor (EGFR) expression are associated with a better survival prognosis in lung adenocarcinoma. The purpose of this study was to detect the molecular evidence of HPV oncoproteins interfering with EGFR nuclear trafficking related to better prognosis in lung cancer. Based on the study results for a better response to cisplatin in transfected HPV 16E5/16E6/16E7 H292 xenograft animal models, as well as better survival in lung adenocarcinoma patients with either 16E6/18E6 or EGFR expression, we suggest that clinicians should adjust the treatment protocol according to HPV 16E6/18E6 expression and EGFR expression to increase the overall survival time in lung cancer. Abstract High-risk human papillomavirus (HPV) infections and epidermal growth factor receptor (EGFR) expression have been reported to be associated with more favorable survival outcomes in lung adenocarcinoma patients. In this study, we utilized transfected HPV 16E5/16E6/16E7 H292 cells to investigate the mechanism of HPV oncoproteins interfering with EGFR nuclear trafficking related to a better response to cisplatin. Furthermore, we correlated HPV 16E6/18E6 expression and differentially localized EGFR expression with the clinical association and survival impact in lung adenocarcinoma patients. Our results found significantly higher phosphorylated nuclear EGFR expression upon epidermal growth factor stimulus and better responses to cisplatin in transfected HPV 16E5/16E6/16E7 NCI-H292 cells and xenograft animal models. Our data were compatible with clinical results of a high correlation of HPV 16E6/18E6 and EGFR expression in non-small cell lung cancer tissues and the synergistic effects of both with the best survival prognosis in a lung adenocarcinoma cohort, especially in patients with older age, no brain metastasis, smoking history, and wild-type EGFR status. Cumulatively, our study supports HPV 16E5/16E6/16E7 oncoproteins interfering with EGFR nuclear trafficking, resulting in increased sensitivity to cisplatin. HPV 16E6/18E6 and EGFR expression serve as good prognostic factors in lung adenocarcinoma patients.
Empirical examination of financial and economic viability of Moringa oleifera production in the Bono East Region, Ghana

ABSTRACT This paper aims to assess the financial and economic viability of Moringa oleifera production as well as processing yield using data collected from 75 moringa farmers and a processing firm in the Bono East Region of Ghana. Descriptive statistics, as well as the discounted and non-discounted measures of project worth, were employed as analytical tools. A three-scenario based sensitivity analysis followed this to measure the robustness of the viability indicators to varying parameter values. The results revealed that an investment in Moringa oleifera production has a payback period of 1 year, 10 months, NPV of GH₵ 4,857.46(US$ 833), a BCR of 1.65 and an IRR of 63%, indicating Moringa oleifera production in the Bono East Region is viable. Considering the viability of this plantation and the potential it portrays for sustainable development, income generation, and job creation, we recommend that governments, Non-Governmental Organizations, and donor agencies support, invest, and encourage the cultivation, consumption, and activities of value addition to Moringa oleifera in their programs. This will lead to nutritional security, youth empowerment and liberation of villages and rural communities from intense poverty. It is also recommended that the government includes moringa plantation in its planting for food and jobs programs.
Changes in body composition and blood parameters in sedentary women during 12 weeks of complex exercises

Background and Study Aim. There are studies examining the effects of exercise programs on body and blood parameters in sedentary individuals, but there are few studies examining the effects of resistance and cardio exercises in combination. The aim of this study was to investigate the effects of step-aerobic, cardio and resistance training on body composition and blood parameters in sedentary women for 12 weeks. Material and Methods. Step- Aerobic, Cardio and Resistance exercises were applied to the volunteers participating in the study for 12 weeks, 3 days a week for 1 hour each. Body weight, body mass index, body fat percentage and body muscle percentage values were determined from body composition measurements before and after the application. Glucose, Vitamin D3, Triglyceride, Cholesterol, High-density lipoprotein and Low-density values were measured from blood parameters. There is no exercise planning was done in the control group. Results. After the exercise program, a significant decrease (p<0.05) in body weight, body mass index, body fat ratio, Glucose, Vitamin D3, Triglyceride, Cholesterol and Low-density values and a significant increase (p<0.05) in High-density lipoprotein and values were determined in the study group. In the control group, no significant change was observed in both body composition and blood parameters (p>0.05). Conclusions. In the this study, it was found resistance, cardio and step-aerobic exercise programs had a positive effect on body composition and blood parameters in sedentary women. In the control group, there is no positive data for the end of the this study and there is no significant change not only body parametres bu also blood measurement in the control group.
Locality and Intervention in the Acquisition of Greek Relative Clauses

According to the most recent formulation of Relativized Minimality, grammatical features are distinguished between those that are syntactically active and those that are not. Under this view, only the first play a role in the computation of locality. Furthermore, whether a certain feature is +/− syntactically active is determined by language-specific factors. Gender is one of the grammatical features that has been argued to have different values in Hebrew vs. Italian, and as a result, to play a role only in Hebrew-speaking children’s comprehension of relative clauses, in terms of intervention effects. Amidst this backdrop, this paper focuses on gender and case, and examines whether or not they have similar effects in the comprehension of relative clauses by Greek-speaking children. Greek differs from Hebrew in that gender does not qualify as a syntactically active feature, hence, the prediction is that it should behave like case, which does not qualify as syntactically active either. The paper presents results from a novel study showing that, indeed, neither gender nor case are responsible for intervention effects in the comprehension of relative clauses by Greek-speaking children, although both features are robustly expressed in Greek nominal morphology.
Gravitational radiation from compact binary systems in Einstein-Maxwell-dilaton theories

We derive the energy fluxes radiated by compact binary systems, including “hairy” black holes, in Einstein-Maxwell-dilaton theories, for circular orbits and at quadrupolar order. This enables to include in their resummed effective-one-body (EOB) dynamics the effect of the radiation reaction force at the origin of their inspiral and merger. We also exhibit typical examples of the resulting tensor and scalar waveforms.
Modeling and Predicting the Short‐Term Evolution of the Geomagnetic Field

We propose a reduced dynamical system describing the coupled evolution of fluid flow and magnetic field at the top of the Earth's core between the years 1900 and 2014. The flow evolution is modeled with a first‐order autoregressive process, while the magnetic field obeys the classical frozen flux equation. An ensemble Kalman filter algorithm serves to constrain the dynamics with the geomagnetic field and its secular variation given by the COV‐OBS.x1 model. Using a large ensemble with 40,000 members provides meaningful statistics including reliable error estimates. The model highlights two distinct flow scales. Slowly varying large‐scale elements include the already documented eccentric gyre. Localized short‐lived structures include distinctly ageostophic features like the high‐latitude polar jet on the Northern Hemisphere. Comparisons with independent observations of the length‐of‐day variations not only validate the flow estimates but also suggest an acceleration of the geostrophic flows over the last century. Hindcasting tests show that our model outperforms simpler predictions bases (linear extrapolation and stationary flow). The predictability limit, of about 2,000 years for the magnetic dipole component, is mostly determined by the random fast varying dynamics of the flow and much less by the geomagnetic data quality or lack of small‐scale information.
Experimental Static Cold Storage of the Rat Uterus: Protective Effects of Relaxin- or Erythropoietin-Supplemented HTK-N Solutions

Uterus transplantation (UTx) is the only treatment method for women with absolute uterine infertility. Currently, the number of grafts retrieved from deceased donors is increasing; hence, prolonged cold ischemia time is inevitable. Thus, this study was designed to assess the effect of the novel relaxin (RLN)- or erythropoietin (EPO)-supplemented Custodiol-N (HTK-N) solutions in an experimental uterus static cold storage (SCS) model. A total of 15 Sprague Dawley rats were used. Uterus horns were randomly assigned into three groups (n = 10/group). SCS was performed by keeping samples at 4 °C in HTK-N solution without or with different additives: 10 IU/mL EPO or 20 nM RLN. Tissue samples were taken after 8 and 24 h of preservation. Uterine tissue histology, and biochemical and immunohistochemical markers were analyzed. No significant differences in SCS-induced tissue damage were observed between groups after 8 h of preservation. Uterine tissue histology, MDA, SOD levels and the TUNEL-positive cell number showed severe damage in HTK-N without additives after 24 h of preservation. This damage was significantly attenuated by adding RLN to the preservation solution. EPO showed no favorable effect. Our study shows that RLN as an additive to an HTK-N solution can serve as an effective uterine tissue preservative in the uterus SCS setting.
Effect of Family Involvement and Corporate Governance on Dividend Policy: A Study of Non-Financial Listed Firms in Morocco

Current research on the determinants of dividend policy has focused on the study of developed countries, while research on emerging countries remains limited. The objective of this research is to study the effect of the involvement of the family firm on dividend policy. This paper uses Ordinary Least Squares regression, we analyzed data for Moroccan nonfinancial firms listed on the Casablanca Stock Exchange over the period 2015-2017. The results of this paper show that family firm pay less dividends than non-family firms. Thus, ownership concentration and firm size influence dividend policy, unlike the composition of the board of directors, which doesn’t influence it. Our paper contributes to broaden our understanding of the effect of the family firm on dividend policy in one of the emerging countries. It is suggested that the characteristics of corporate ownership determine the share of profits to be distributed, not to say dividend policy, since concentration of ownership limits the power of minority shareholders to make their voices heard. Despite the presence of laws protecting minority shareholders, their room for maneuver remains limited. Our paper enriches the existing literature on the family firm dividend policy by studying the Moroccan context. The results show that family ownership and family CEO involvement do not have the same influence on the dividend policy of family firms, but it depends on the context. Our paper also provides relevant information for practitioners regarding dividend policy in Moroccan family firms.
Understanding the orbital periods of CEMP-s stars

The chemical enrichments detected in carbon- and s-element-enhanced metal-poor (CEMP-s) stars are believed to be the consequence of a past episode of mass transfer from a now extinct asymptotic-giant-branch primary star. This hypothesis is borne out by the evidence that most CEMP-s stars exhibit radial-velocity variations suggesting that they belong to binary systems in which the companion is not directly visible. We used the orbital-period distribution of an unbiased sample of observed CEMP-s stars to investigate the constraints it imposes on our models of binary evolution and on the properties of the metal-poor binary population in the Galactic halo. We generated synthetic populations of metal-poor binary stars using different assumptions about the initial period distribution and about the physics of the mass-transfer process, and we compared the predicted period distributions of our synthetic CEMP-s stars with the observed one. With a set of default assumptions often made in binary population-synthesis studies, the observed period distribution cannot be reproduced. The percentage of observed CEMP-s systems with periods shorter than about 2000 days is underestimated by almost a factor of three, and by about a factor of two between 3000 and 10 000 days. Conversely, about 40% of the simulated systems have periods longer than 104 days, which is approximately the longest measured period among CEMP-s stars. Variations in the assumed stability criterion for Roche-lobe overflow and the efficiency of wind mass transfer do not alter the period distribution enough to overcome this discrepancy. To reconcile the results of the models with the orbital properties of observed CEMP-s stars, one or both of the following conditions are necessary: (i) the specific angular momentum carried away by the material that escapes the binary system is approximately two to five times higher than currently predicted by analytical models and hydrodynamical simulations of wind mass transfer, and (ii) the initial period distribution of very metal-poor binary stars is significantly different from that observed in the solar vicinity and weighted towards periods shorter than about ten thousand days. Our simulations show that some, perhaps all, of the observed CEMP-s stars with apparently constant radial velocity could be undetected binaries with periods longer than 104 days, but the same simulations also predict that twenty to thirty percent of detectable binaries should have periods above this threshold, much more than are currently observed.
Dietary Antioxidant Curcumin Mitigates CuO Nanoparticle-Induced Cytotoxicity through the Oxidative Stress Pathway in Human Placental Cells

The placenta is an important organ that maintains a healthy pregnancy by transporting nutrients to the fetus and removing waste from the fetus. It also acts as a barrier to protect the fetus from hazardous materials. Recent studies have indicated that nanoparticles (NPs) can cross the placental barrier and pose a health risk to the developing fetus. The high production and widespread application of copper oxide (CuO) NPs may lead to higher exposure to humans, raising concerns of health hazards, especially in vulnerable life stages, e.g., pregnancy. Oxidative stress plays a crucial role in the pathogenesis of adverse pregnancy outcomes. Due to its strong antioxidant activity, dietary curcumin can act as a therapeutic agent for adverse pregnancy. There is limited knowledge on the hazardous effects of CuO NPs during pregnancy and their mitigation by curcumin. This study aimed to investigate the preventive effect of curcumin against CuO NP-induced toxicity in human placental (BeWo) cells. CuO NPs were synthesized by a facile hydrothermal process and characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and photoluminescence techniques. We observed that curcumin did not induce toxicity in BeWo cells (1–100 µg/mL for 24 h), whereas CuO NPs decreased the cell viability dose-dependently (5–200 µg/mL for 24 h). Interestingly, CuO NP-induced cytotoxicity was effectively mitigated by curcumin co-exposure. The apoptosis data also exhibited that CuO NPs modulate the expression of several genes (p53, bax, bcl-2, casp3, and casp9), the activity of enzymes (caspase-3 and -9), and mitochondrial membrane potential loss, which was successfully reverted by co-treatment with curcumin. The mechanistic study suggested that CuO-induced reactive oxygen species generation, lipid peroxidation, and higher levels of hydrogen peroxide were significantly alleviated by curcumin co-exposure. Moreover, glutathione depletion and the lower activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase) were effectively mitigated by curcumin. We believe this is the first report exhibiting that CuO-induced toxicity in BeWo cells can be effectively alleviated by curcumin. The pharmacological potential of dietary curcumin in NP-induced toxicity during pregnancy warrants further investigation.