Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of the super-powerful tropospheric western Pacific phenomenon of September–October 2018 on the ionosphere over China: results from oblique sounding

Abstract. Doppler measurements at oblique propagation paths from the city of Harbin, the People's Republic of China (PRC), to 10 high-frequency (HF) radio broadcast stations in the PRC, Japan, Mongolia, and the Republic of Korea captured the response in the ionosphere to the activity of the super typhoon, Typhoon Kong-rey, from 30 September to 6 October 2018. The Harbin Engineering University coherent software-defined radio system generates the database containing the complex amplitudes of the radio signals that have been acquired along 14 propagation paths since 2018. The complex amplitudes are used for calculating the temporal dependences of the Doppler spectra and signal amplitudes, and the Doppler spectra are used to plot the Doppler shift as a function of time, fD(t), for all rays. The scientific objectives of this study are to reveal the possible perturbations caused by the activity of Typhoon Kong-rey and to estimate the magnitudes of wave parameters of the ionospheric plasma and radio signals. The amplitudes, fDa, of the Doppler shift variations were observed to noticeably increase (factor of ∼2–3) on 1–2 and 5–6 October 2018, while the 20–120 min periods, T, of the Doppler shift variations suggest that the wavelike disturbances in the ionosphere are caused by atmospheric gravity waves. The periods and amplitudes of quasi-sinusoidal variations in the Doppler shift, which have been determined for all propagation paths, may be used to estimate the amplitudes, δNa, of quasi-sinusoidal variations in the electron density. Thus, T≈20 min and fDa≈0.1 Hz yield δNa≈0.4 %, whereas T≈30 min and fDa≈0.2 Hz give δNa≈1.2 %. If T≈60 min and fDa≈0.5 Hz, then δNa≈6 %. The periods T are found to change within the 15–120 min limits, and the Doppler shift amplitudes, fDa, show variability within the 0.05–0.4 Hz limits.
CCL2-Mediated Stromal Interactions Drive Macrophage Polarization to Increase Breast Tumorigenesis

CCL2 is an inflammatory cytokine that regulates macrophage activity and is implicated in increased mammographic density and early breast tumorigenesis. The role of CCL2 in mediating stromal interactions that contribute to breast tumorigenesis has yet to be fully elucidated. THP-1-derived macrophages and mammary fibroblasts were co-cultured for 72 h. Fibroblasts and macrophages were analysed for phenotype, expression of inflammatory and ECM-regulatory genes and collagen production. Mice overexpressing CCL2 in the mammary glands were analysed for global gene expression by RNAseq at 12 weeks of age. These mice were cross-bred with PyMT mammary tumour mice to examine the role of CCL2 in tumorigenesis. The co-culture of macrophages with fibroblasts resulted in macrophage polarization towards an M2 phenotype, and upregulated expression of CCL2 and other genes associated with inflammation and ECM remodelling. CCL2 increased the production of insoluble collagen by fibroblasts. A global gene expression analysis of CCL2 overexpressing mice revealed that CCL2 upregulates cancer-associated gene pathways and downregulates fatty acid metabolism gene pathways. In the PyMT mammary tumour model, CCL2 overexpressing mice exhibited increased macrophage infiltration and early tumorigenesis. Interactions between macrophages and fibroblasts regulated by CCL2 can promote an environment that may increase breast cancer risk, leading to enhanced early tumorigenesis.
In Vitro and In Silico Investigation of Polyacetylenes from Launaea capitata (Spreng.) Dandy as Potential COX-2, 5-LOX, and BchE Inhibitors

Diverse secondary metabolites are biosynthesized by plants via various enzymatic cascades. These have the capacity to interact with various human receptors, particularly enzymes implicated in the etiology of several diseases. The n-hexane fraction of the whole plant extract of the wild edible plant, Launaea capitata (Spreng.) Dandy was purified by column chromatography. Five polyacetylene derivatives were identified, including (3S,8E)-deca-8-en-4,6-diyne-1,3-diol (1A), (3S)-deca-4,6,8-triyne-1,3-diol (1B), (3S)-(6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (2), bidensyneoside (3), and (3S)-(6E,12E)-tetradecadiene-8,10-diyne-1-ol-3-O-β-D-glucopyranoside (4). These compounds were investigated for their in vitro inhibitory activity against enzymes involved in neuroinflammatory disorders, including cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and butyrylcholinesterase (BchE) enzymes. All isolates recorded weak–moderate activities against COX-2. However, the polyacetylene glycoside (4) showed dual inhibition against BchE (IC50 14.77 ± 1.55 μM) and 5-LOX (IC50 34.59 ± 4.26 μM). Molecular docking experiments were conducted to explain these results, which showed that compound 4 exhibited greater binding affinity to 5-LOX (−8.132 kcal/mol) compared to the cocrystallized ligand (−6.218 kcal/mol). Similarly, 4 showed a good binding affinity to BchE (−7.305 kcal/mol), which was comparable to the cocrystallized ligand (−8.049 kcal/mol). Simultaneous docking was used to study the combinatorial affinity of the unresolved mixture 1A/1B to the active sites of the tested enzymes. Generally, the individual molecules showed lower docking scores against all the investigated targets compared to their combination, which was consistent with the in vitro results. This study demonstrated that the presence of a sugar moiety (in 3 and 4) resulted in dual inhibition of 5-LOX and BchE enzymes compared to their free polyacetylenes analogs. Thus, polyacetylene glycosides could be suggested as potential leads for developing new inhibitors against the enzymes involved in neuroinflammation.
Post-Exercise Ankle–Brachial Index Is Reduced in Healthy, Young Individuals at a Level Indicating Peripheral Artery Disease

In young patients referred for exercise-induced pain in the legs, false positive tests are a potential problem for the post-exercise ankle–brachial index (ABI) test when using the current American Heart Association guidelines for diagnosing peripheral artery disease (PAD). The present study aimed to investigate post-exercise ABI in healthy young people, and to explore whether the current diagnostic criteria for pathological ABI should be revised. Forty-eight volunteers (18–30 years) were included. Resting examinations included ABI and ultrasound of the external iliac artery. Post-exercise examinations after a treadmill load included ABI and ultrasound of the external iliac artery; after 0 min and after 3 min. A total of 60.5% of the participants had a post-exercise decrease in ABI > 20%. A total of 6.5% showed a decrease in ankle systolic blood pressure >30 mmHg. No significant association was observed between a change in blood flow in the external iliac artery and a reduction in ABI post-exercise. Analyses of the ultrasound recordings showed no turbulence in the external iliac artery. According to the results, a 20% decrease in ABI post-exercise seems to be a physiological condition present in young people. We support the need for a reassessment of the criteria for diagnosing PAD.
Explosive fragmentation of liquid shells

The forced radial expansion of a spherical liquid shell by an exothermic chemical reaction is a prototypical configuration for the explosion of cohesive materials in three dimensions. The shell is formed by the capillary pinch off of a thin liquid annular jet surrounding a jet of reactive gaseous mixture at ambient pressure. The encapsulated gas in the resulting liquid bubble is a mixture of hydrogen and oxygen in controlled relative proportions, which is ignited by a laser plasma aimed at the centre of the bubble. The strongly exothermic combustion of the mixture induces the expansion of the hot burnt gas, pushing the shell radially outwards in a violently accelerated motion. That motion triggers the instability of the shell, developing thickness modulations ultimately piercing it in a number of places. The capillary retraction of the holes concentrates the liquid constituting the shell into a web of ligaments, whose breakup leads to stable drops. We offer a comprehensive description of the overall process, from the kinematics of the shell initial expansion, to the final drop size distribution as a function of the composition of the gas mixture, the initial shell radius and thickness.
Valorization of Food Waste as Animal Feed: A Step towards Sustainable Food Waste Management and Circular Bioeconomy

Simple Summary Have you ever thrown away food that you didn’t eat? Most people do this all around the world but throwing away food can actually harm the environment. One way to reduce this harm is by turning the food scraps into animal feed. This not only helps the environment but also makes livestock production cheaper. Different technologies have been developed to make a safe and healthy animal feed from food waste. This helps us to get rid of waste by giving animals a new source of protein and recycling the discarded food waste. This article talks about how to turn food waste into animal food and its advantages. However, it is important to make sure the feed is of high quality and safe for the animals. It is also important to do research and development to make even better food-waste-based animal feed by reducing production costs and waste disposal, thereby making things better for both the animals and the environment. Overall, using food waste as animal food is a good waste management idea that provides food security and preserves the environment. So, next time when you have some leftover food, remember that it could be turned into something useful instead of being thrown away. Abstract The growing population and healthy food demands have led to a rise in food waste generation, causing severe environmental and economic impacts. However, food waste (FW) can be converted into sustainable animal feed, reducing waste disposal and providing an alternative protein source for animals. The utilization of FW as animal feed presents a solution that not only tackles challenges pertaining to FW management and food security but also lessens the demand for the development of traditional feed, which is an endeavour that is both resource and environmentally intensive in nature. Moreover, this approach can also contribute to the circular economy by creating a closed-loop system that reduces the use of natural resources and minimizes environmental pollution. Therefore, this review discusses the characteristics and types of FW, as well as advanced treatment methods that can be used to recycle FW into high-quality animal feed and its limitations, as well as the benefits and drawbacks of using FW as animal feed. Finally, the review concludes that utilization of FW as animal feed can provide a sustainable solution for FW management, food security, preserving resources, reducing environmental impacts, and contributing to the circular bioeconomy.
How Media’s factor and governmental factor affected individual’s opinion on haze in China

Understanding the underlying mechanism of individual’s opinion on haze is important to govern public opinion on haze, and the major question of exiting research is that it has not yet explored what factors and how do they affect individual’s opinion on haze. This study aimed to uncover the underlying influencing mechanism of individual’s opinion on haze. This study conducted Partial Least Square Structural equation Modeling (PLS-SEM) to examine the impacts of media’s factor (i.e. agenda setting, media accountability, and information credibility), governmental factor (i.e. policy instrument) and psychological factor (i.e., social distance, spatial distance) on individual’s opinion on haze. Based on the Agenda Melding Theory and stakeholders (i.e., media, government, and resident), this study constructed a conceptual model, which is empirically examined by conducting questionnaire survey data of 973 residents in China. The results indicate that media’s factor (media accountability, information credibility), governmental factor (policy instrument), and psychological distance have significant positive direct impacts on individual’s opinion on haze. Furthermore, media’s factor (agenda setting) only has an indirect impact on individual’s opinion on haze through the mediation effects of information credibility. However, information credibility also had significant moderation effects on the relationship between psychological distance and individual’s opinion on haze. The moderation and mediation effects of information credibility indicated that it played a vital role in guiding individual’s opinion on haze. These findings suggest that further research is required on the interaction of stakeholders and that concerted efforts of different stakeholders to assist governing individual’s opinion on haze.
Wetting Characteristics of Laser-Ablated Hierarchical Textures Replicated by Micro Injection Molding

Texturing can be used to functionalize the surface of plastic parts and, in particular, to modify the interaction with fluids. Wetting functionalization can be used for microfluidics, medical devices, scaffolds, and more. In this research, hierarchical textures were generated on steel mold inserts using femtosecond laser ablation to transfer on plastic parts surface via injection molding. Different textures were designed to study the effects of various hierarchical geometries on the wetting behavior. The textures are designed to create wetting functionalization while avoiding high aspect ratio features, which are complex to replicate and difficult to manufacture at scale. Nano-scale ripples were generated over the micro-scale texture by creating laser-induced periodic surface structures. The textured molds were then replicated by micro-injection molding using polypropylene and poly(methyl methacrylate). The static wetting behavior was investigated on steel inserts and molded parts and compared to the theoretical values obtained from the Cassie–Baxter and Wenzel models. The experimental results showed correlations between texture design, injection molding replication, and wetting properties. The wetting behavior on the polypropylene parts followed the Cassie–Baxter model, while for PMMA, a composite wetting state of Cassie–Baxter and Wenzel was observed.
Optimized two- and three-colour laser pulses for the intense terahertz wave generation

Abstract Based on the photocurrent model, we perform a theoretical study on the optimization of terahertz (THz) wave emission from argon gas irradiated by the two- and three-colour laser fields. To obtain stronger THz radiation for the given conditions, a genetic algorithm method is applied to search for the optimum laser parameters. For the two-colour field, our optimizations reveal two types of optimal scheme, and each one dominates the THz generation in different regions of intensity ratio for a given total laser intensity. One scheme is the combination of a fundamental laser pulse and its second harmonic, while the other is the fundamental pulse with its fourth harmonic. For each scheme, the optimal intensity ratio and phase delay are obtained. For the three-colour case, our optimization shows that the excellent waveform for the strongest THz radiation is composed of a fundamental laser pulse, and its second, third harmonics, with appropriate intensity ratio and carrier-envelope phase. Such a 3-colour field can generate strong THz radiation comparable with a 10-colour sawtooth wave [Martínez et al., Phys. Rev. Lett. 114, 183901 (2015)]. The physical mechanisms for the enhancement of THz wave emission in gases are also discussed in detail. Our results give helpful guidance for intense THz generation with tabletop femtosecond laser device in experiment.
Response of Little Millet Varieties to Different Levels of Fertilizers Under Rainfed Condition

An experiment was conducted during kharif 2016 at Post Graduate Research Farm, College of Agriculture, Kolhapur Maharashtra. The objectives of experiment were to find out suitable varieties of little millet, to study the fertilizer requirement of little millet, the interaction effects of fertilizer and variety on little millet and the economics of different treatments in little millet. The growth attributing characters of little millet expressed in terms of plant height, number of functional leaves hill -1, number of tillers hill -1, leaf area and dry matter accumulation plant-1 were significantly higher in PhuleEkadashi and application of 150 per cent RDF. The Phule Ekadashi variety recorded significantly highest grain (13.45 q ha-1) and straw (16.21 q ha-1) yield over OLM 203 (viz., 9.70 and 12.83 q ha-1 grain and straw yield respectively). The fertilizer level 150 per cent RDF recorded significantly highest grain 13.40 q ha-1 and straw 16.10 q ha-1 yields followed by 125 per cent RDF 12.60 and 15.87 q ha-1 grain and straw respectively. The fertilizer level 100 per cent and 75 per cent RDF recorded lowest grain and straw yield as compared to 125 and 150 per cent RDF. The variety PhuleEkadashi recorded significantly higher net (Rs. 24695 ha-1) monetary returns, benefit cost ratio (1.84) over OLM 203 viz., net (Rs. 9695 ha-1) monetary returns, benefit cost ratio (1.33).
Development of a High-Throughput Urosepsis Mouse Model

Murine sepsis models are typically polymicrobial, and are associated with high mortality. We aimed to develop a high-throughput murine model that mimics a slow-paced, monomicrobial sepsis originating from the urinary tract. A total of 23 male C57Bl/6 mice underwent percutaneous insertion of a 4 mm catheter into the bladder using an ultrasound-guided method, previously developed by our group. The following day, Proteus mirabilis (PM) was introduced percutaneously in the bladder in three groups: g1—50 µL 1 × 108 CFU/mL solution (n = 10); g2—50 µL 1 × 107 CFU/mL solution (n = 10); and g3 (sham mice)—50 µL sterile saline (n = 3). On day 4, mice were sacrificed. The number of planktonic bacteria in urine, adherent to catheters, and adherent to/invaded into the bladder and spleen was assessed. Cell-free DNA, D-dimer, thrombin–antithrombin complex (TAT), and 32 pro-/anti-inflammatory cytokines/chemokines were quantified in the blood. All mice survived the 4 day postinterventional period. Mean weight loss was 11% in g1, 9% in g2, and 3% in the control mice. Mean urine CFU counts were highest in group 1. All catheters showed high catheter-adhered bacterial counts. Of the infected mice, 17/20 had CFU counts in the splenic tissue, indicating septicemia. Plasma levels of cell-free DNA, D-dimer, and the proinflammatory cytokines IFN-γ, IL-6, IP-10, MIG, and G-CSF were significantly elevated in infected mice versus controls. We present a reproducible, monomicrobial murine model of urosepsis that does not lead to rapid deterioration and death, and is useful for studying prolonged urosepsis.
HCFC-141b (CH3CCl2F) Emission Estimates for 2000–2050 in Eastern China

HCFC-141b (CH 3 CCl 2 F) has dual environmental impacts on ozone depletion and climate change, with the ozone depletion potential of 0.11 and the global warming potential of 782, and its emissions has attracted international attention. Under the control of the Montreal Protocol, China should phase out the production and consumption of HCFC-141b by 2030. This study firstly estimated the HCFC-141b emissions in eastern China based on the bottom-up method during 2000-2019. The results show that the HCFC-141b emissions in eastern China increased from 0.4 Gg yr –1 in 2000 to 7.1 Gg yr –1 in 2019, and there was a bank of 253.6 Gg in PU foam products in 2019, which may have an impact on the future HCFC-141b emissions. In addition, the HCFC-141b emissions were predicted in eastern China from 2020–2050 under the baseline scenario (BAU), the Montreal Protocol scenario (MP), and the accelerated phase-out scenario (AP), and the emission potential was analyzed. The results show that the HCFC-141b emissions increased rapidly under the BAU scenario, with the cumulative emissions of 1162.6 Gg in 2020–2050. Under the MP and AP scenarios, the cumulative HCFC-141b emission reduction potential from 2020 to 2050 will be 1002.1 Gg (equivalent to 110.2 Gg CFC-11-eq and 783.6 Tg CO 2 -eq) and 1034.8 Gg (equivalent to 113.8 Gg CFC-11-eq and 809.2 Tg CO 2 -eq), respectively. Compared with the MP scenario, under the AP scenario, eastern China will get an additional emission reduction potential of 32.7 Gg (equivalent to 3.6 Gg CFC-11-eq and 25.5 Tg CO 2 -eq) during 2020–2050, which will make greater contributions to protecting the ozone layer and mitigating climate change.
Vibration During Acceleration Through a Critical Speed

This paper gives an exact solution of the problem of running a system having a single degree of freedom and linear damping through its critical speed from rest at a uniform acceleration. An exact expression is found for the envelope in which are located the maximum amplitudes. The results are plotted for various rates of acceleration and for various dampings.
Understanding the experiences of caregivers of HIV-exposed children under five: A phenomenological inquiry

Background Children born to mothers with HIV require special care from the womb to the postnatal period, and caregivers involved in their care face several challenges. Objective This study aimed to explore caregivers’ experiences providing care for HIV-exposed children under five. Methods This study employed a phenomenological approach. Ten caregivers of HIV-exposed children living in Jakarta, Indonesia, were selected using snowball techniques. Online in-depth interviews were conducted to collect data from September 2021 to July 2022, and thematic analysis using Colaizzi’s method was performed for data analysis. Results The study involved ten caregivers (nine females and one male) aged between 23 and 42 years. Seven of them were mothers who tested HIV-positive, while one was an adoptive father, one was a mother’s sister, and one was an aunt of HIV-exposed children. The majority of them were housewives and had a low educational background. Three themes were generated: (i) disease-transmission foreboding, (ii) prejudice against mothers and children exposed to HIV, and (iii) seeking support. Conclusion Caring for HIV-exposed children poses emotional and physical challenges for caregivers, necessitating support from health professionals and peer groups. Nurses play essential roles in improving caregiver well-being and supporting optimal growth and development in HIV-exposed children under five by designing intervention programs. Furthermore, to enhance home-based HIV care in Indonesia, the government must implement social interventions that target families with limited resources.
Pharmacogenomics on the Treatment Response in Patients with Psoriasis: An Updated Review

The efficacy and the safety of psoriasis medications have been proved in trials, but unideal responses and side effects are noted in clinical practice. Genetic predisposition is known to contribute to the pathogenesis of psoriasis. Hence, pharmacogenomics gives the hint of predictive treatment response individually. This review highlights the current pharmacogenetic and pharmacogenomic studies of medical therapy in psoriasis. HLA-Cw*06 status remains the most promising predictive treatment response in certain drugs. Numerous genetic variants (such as ABC transporter, DNMT3b, MTHFR, ANKLE1, IL-12B, IL-23R, MALT1, CDKAL1, IL17RA, IL1B, LY96, TLR2, etc.) are also found to be associated with treatment response for methotrexate, cyclosporin, acitretin, anti-TNF, anti-IL-12/23, anti-IL-17, anti-PDE4 agents, and topical therapy. Due to the high throughput sequencing technologies and the dramatic increase in sequencing cost, pharmacogenomic tests prior to treatment by whole exome sequencing or whole genome sequencing may be applied in clinical in the future. Further investigations are necessary to manifest potential genetic markers for psoriasis treatments.