Miracle-dz/UniFAR-FTUs huggingface dataset:
Progression Rates of LR-2 and LR-3 Observations on MRI to Higher LI-RADS Categories in Patients at High Risk for Hepatocellular Carcinoma: A Retrospective Study.

Background: Reported rates of hepatocellular carcinoma (HCC) for LR-2 and LR-3 observations are generally greater than what may be expected based on clinical experience, possibly reflecting some studies' requirement for pathologic reference. Objective: To determine progression rates to higher LI-RADS categories of LR-2 and LR-3 observations in patients at high risk for HCC. Methods: This retrospective study included 91 patients (mean age 62 years; 64 men, 27 women) at high risk for HCC with clinically reported LR-2 (n=55) or LR-3 (n=36) observations on MRI and who also underwent follow-up CT or MRI after at least 12 months. A study coordinator annotated the location of a single LR-2 or LR-3 observation per patient, based on the clinical reports. Using LI-RADS v2018 criteria, two radiologists independently assigned LI-RADS categories on the follow-up examinations. Progression rates from LR-2 or LR-3 to higher categories were determined. A post hoc consensus review was performed of observations that progressed to LR-4 or LR-5. Subgroup analyses were performed with respect to presence or prior HCC (n=34) or a separate baseline LR-5 observation (n=12). Results: For LR-2 observations, progression to LR-4 was 0.0% (95% CI 0.0%-6.7%) and LR-5 was 3.6% (95% CI 0.4%-13.1%) for both readers. For LR-3 observations, progression to LR-4 was 22.2% (95% CI 9.6%-43.8%) and LR-5 was 11.1% (95% CI 3.0%-28.4%) for both readers. Fourteen observations progressed to LR-4 or LR-5 for both readers (post hoc analysis: no LR-2 to LR-4; two LR-2 to LR-5; eight LR-3 to LR-4; four LR-3 to LR-5). Progression rate from LR-3 to LR-5 was higher (p<.001) among patients with versus without a separate baseline LR-5 observation (100.0% vs 3.0%, respectively) for both readers; progression rate from LR-2 to LR-5 was not associated with a separate baseline LR-5 observation for either reader (p=.30). Progression rates were not different (p>.99) between patients with versus without prior HCC. Conclusion: Based on progression to LR-4 or LR-5, LR-2 and LR-3 observations showed lower progression rates than reported in studies incorporating pathology in determining progression. Clinical Impact: The findings refine understanding of the clinical significance of LR-2 and LR-3 observations.
The Bacterial Control of Poly (Lactic Acid) Nanofibers Loaded with Plant-Derived Monoterpenoids via Emulsion Electrospinning

Plant-derived monoterpenoids have been shown to possess various biological effects, providing a scientific basis for their potential usage as antibacterial agents. Therefore, considering problems surrounding bacteria′s antibacterial resistance, the utilization of natural antimicrobial compounds such as monoterpenoids in different industries has gained much attention. The aim of this study was to fabricate and characterize various concentrations of plant-derived monoterpenoids, geraniol (G) and carvacrol (C), loaded into poly(lactic acid) (PLA) nanofibers via emulsion electrospinning. The antibacterial activities of the fabricated nanofibers were evaluated using three types of antibacterial assays (inhibition zone tests, live/dead bacterial cell assays, and antibacterial kinetic growth assays). Among the samples, 10 wt% carvacrol-loaded PLA nanofibers (C10) had the most bactericidal activity, with the widest inhibition zone of 5.26 cm and the highest visible dead bacteria using the inhibition zone test and live/dead bacterial cell assay. In order to quantitatively analyze the antibacterial activities of 5 wt% carvacrol-loaded PLA nanofibers (C5), C10, 5 wt% geraniol-loaded PLA nanofibers (G5), and 10 wt% geraniol-loaded PLA nanofibers (G10) against E. coli and S. epidermidis, growth kinetic curves were analyzed using OD600. For the results, we found that the antibacterial performance was as follows: C10 > C5 > G10 > G5. Overall, carvacrol or geraniol-loaded PLA nanofibers are promising antibacterial materials for improving fiber functionality.
The Bacterial Life Cycle in Textiles is Governed by Fiber Hydrophobicity

During sweating, bacteria from the skin enter the worn textile along with the sweat. Once inside the clothes, the bacteria produce sweat malodor and form colonies that are extremely hard to remove by washing. ABSTRACT Colonization of textiles and subsequent metabolic degradation of sweat and sebum components by axillary skin bacteria cause the characteristic sweat malodor and discoloring of dirty clothes. Once inside the textile, the bacteria can form biofilms that are hard to remove by conventional washing. When the biofilm persists after washing, the textiles retain the sweat odor. To design biofilm removal and prevention strategies, the bacterial behavior needs to be understood in depth. Here, we aim to study the bacterial behavior in each of the four stages of the bacterial life cycle in textiles: adhesion, growth, drying, and washing. To accomplish this, we designed a novel in vitro model to mimic physiological sweating in cotton and polyester textiles, in which many of the parameters that influence bacterial behavior could be controlled. Due to the higher hydrophobicity, polyester adhered more bacteria and absorbed more sebum, the bacteria’s primary nutrient source. Bacteria were therefore also more active in polyester textiles. However, polyester did not bind water as well as cotton. The increased water content of cotton allowed some species to retain a higher activity after the textile had dried. However, none of the textiles retained enough water upon drying to prevent the bacteria from adhering irreversibly to the textile fibers. This work demonstrates that bacterial colonization of textiles depends partially on the hydrophobic and hygroscopic properties of the textile material, indicating that it might be possible to direct bacterial behavior in a more favorable direction by modifying these surface properties. IMPORTANCE During sweating, bacteria from the skin enter the worn textile along with the sweat. Once inside the clothes, the bacteria produce sweat malodor and form colonies that are extremely hard to remove by washing. Over time, this leads to a decreasing textile quality and consumer comfort. To design prevention and removal mechanisms, we investigated the behavior of bacteria during the four stages of their life cycle in textiles: adhesion, growth, drying, and washing. The bacterial behavior in textiles during all four stages is found to be affected by the textile’s ability to bind water and fat. The study indicates that sweat malodor and bacterial accumulation in textiles over time can be reduced by making the textiles more repellant to water and fat.
Effect of Processing Techniques on the Microstructure and Mechanical Performance of High-Density Polyethylene

The versatility of high-density polyethylene (HDPE) makes it one of the most used polymers for vast applications ranging from food packaging to human implants. However, there still is confusion regarding the proper selection of processing techniques to produce HDPE specimens for high-end applications. Herein, we compare the processing of HDPE by two relevant techniques: compression and injection molding. The fabricated samples were studied using uniaxial tensile testing to determine their mechanical performance. Furthermore, the microstructure of samples was analyzed using different characterization techniques. Compression-molded specimens recorded a higher degree of crystallinity (DC) using two different characterization techniques such as differential scanning calorimetry (DSC) and X-ray diffraction (XRD). With this information, critical processing factors were determined, and a general structure–property relationship was established. It was demonstrated that having a higher DC resulted in higher yield strength and Young’s modulus. Furthermore, premature failure was observed in the injection-molded specimens, resulting in lower mechanical performance. This premature failure was caused due to flow marks observed using scanning electron microscopy (SEM). Therefore, it is concluded that compression molding produces superior samples compared to injection molding.
Aspergillus Lateral Flow Assay with Digital Reader for the Diagnosis of COVID-19-Associated Pulmonary Aspergillosis (CAPA): a Multicenter Study

This multicenter study evaluated the IMMY Aspergillus Galactomannan Lateral Flow Assay (LFA) with automated reader for diagnosis of pulmonary aspergillosis in patients with COVID-19-associated acute respiratory failure (ARF) requiring intensive care unit (ICU) admission between 03/2020 and 04/2021. A total of 196 respiratory samples and 148 serum samples (n = 344) from 238 patients were retrospectively included, with a maximum of one of each sample type per patient. ABSTRACT This multicenter study evaluated the IMMY Aspergillus Galactomannan Lateral Flow Assay (LFA) with automated reader for diagnosis of pulmonary aspergillosis in patients with COVID-19-associated acute respiratory failure (ARF) requiring intensive care unit (ICU) admission between 03/2020 and 04/2021. A total of 196 respiratory samples and 148 serum samples (n = 344) from 238 patients were retrospectively included, with a maximum of one of each sample type per patient. Cases were retrospectively classified for COVID-19-associated pulmonary aspergillosis (CAPA) status following the 2020 consensus criteria, with the exclusion of LFA results as a mycological criterion. At the 1.0 cutoff, sensitivity of LFA for CAPA (proven/probable/possible) was 52%, 80% and 81%, and specificity was 98%, 88% and 67%, for bronchoalveolar lavage fluid (BALF), nondirected bronchoalveolar lavage (NBL), and tracheal aspiration (TA), respectively. At the 0.5 manufacturer’s cutoff, sensitivity was 72%, 90% and 100%, and specificity was 79%, 83% and 44%, for BALF, NBL and TA, respectively. When combining all respiratory samples, the receiver operating characteristic (ROC) area under the curve (AUC) was 0.823, versus 0.754, 0.890 and 0.814 for BALF, NBL and TA, respectively. Sensitivity and specificity of serum LFA were 20% and 93%, respectively, at the 0.5 ODI cutoff. Overall, the Aspergillus Galactomannan LFA showed good performances for CAPA diagnosis, when used from respiratory samples at the 1.0 cutoff, while sensitivity from serum was limited, linked to weak invasiveness during CAPA. As some false-positive results can occur, isolated results slightly above the recommended cutoff should lead to further mycological investigations.
Caput Ligation Renders Immature Mouse Sperm Motile and Capable to Undergo cAMP-Dependent Phosphorylation

Mammalian sperm must undergo two post-testicular processes to become fertilization-competent: maturation in the male epididymis and capacitation in the female reproductive tract. While caput epididymal sperm are unable to move and have not yet acquired fertilization potential, sperm in the cauda epididymis have completed their maturation, can move actively, and have gained the ability to undergo capacitation in the female tract or in vitro. Due to the impossibility of mimicking sperm maturation in vitro, the molecular pathways underlying this process remain largely unknown. We aimed to investigate the use of caput epididymal ligation as a tool for the study of sperm maturation in mice. Our results indicate that after seven days of ligation, caput sperm gained motility and underwent molecular changes comparable with those observed for cauda mature sperm. Moreover, ligated caput sperm were able to activate pathways related to sperm capacitation. Despite these changes, ligated caput sperm were unable to fertilize in vitro. Our results suggest that transit through the epididymis is not required for the acquisition of motility and some capacitation-associated signaling but is essential for full epididymal maturation. Caput epididymal ligation is a useful tool for the study of the molecular pathways involved in the acquisition of sperm motility during maturation.
DNA barcode to trace the development and differentiation of cord blood stem cells

Umbilical cord blood transplantation was first reported in 1980. Since then, additional research has indicated that umbilical cord blood stem cells (UCBSCs) have various advantages, such as multi-lineage differentiation potential and potent renewal activity, which may be induced to promote their differentiation into a variety of seed cells for tissue engineering and the treatment of clinical and metabolic diseases. Recent studies suggested that UCBSCs are able to differentiate into nerve cells, chondrocytes, hepatocyte-like cells, fat cells and osteoblasts. The culture of UCBSCs has developed from feeder-layer to feeder-free culture systems. The classical techniques of cell labeling and tracing by gene transfection and fluorescent dye and nucleic acid analogs have evolved to DNA barcode technology mediated by transposon/retrovirus, cyclization recombination-recombinase and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 strategies. DNA barcoding for cell development tracing has advanced to include single cells and single nucleic acid mutations. In the present study, the latest research findings on the development and differentiation, culture techniques and labeling and tracing of UCBSCs are reviewed. The present study may increase the current understanding of UCBSC biology and its clinical applications.
Preparation and Properties of Sustainable Brake Pads with Recycled End-of-Life Tire Rubber Particles

Sustainable composite brake pads were processed by employing recycled end-of-life tire (ELT) rubber particles obtained by means of cryogenic grinding and ambient grinding. The effect of the grinding mechanism and concentration of ELT rubber particles was then reported. From the friction result test, better behavior in terms of coefficient of friction (COF) was obtained when 3% of ELT rubber particles were introduced into the composite. It was demonstrated that the size of the particles is not as determinant as the friction mechanism in the wear properties of the sustainable brake pads. Whereas, while increasing the ELT rubber particle size acts as detrimental to the COF either in the ambient or cryogenic grinding, at high friction distances, the better adhesion of the particles because of the rough surface of the particles subjected to ambient grinding enhances the long-life behavior of the composite brake pads.
Insights on the Electrocatalytic Seawater Splitting at Heterogeneous Nickel-Cobalt Based Electrocatalysts Engineered from Oxidative Aniline Polymerization and Calcination

Given the limited access to freshwater compared to seawater, a growing interest surrounds the direct seawater electrolysis to produce hydrogen. However, we currently lack efficient electrocatalysts to selectively perform the oxygen evolution reaction (OER) over the oxidation of the chloride ions that are the main components of seawater. In this contribution, we report an engineering strategy to synthesize heterogeneous electrocatalysts by the simultaneous formation of separate chalcogenides of nickel (NiSx, x = 0, 2/3, 8/9, and 4/3) and cobalt (CoSx, x = 0 and 8/9) onto a carbon-nitrogen-sulfur nanostructured network. Specifically, the oxidative aniline polymerization in the presence of metallic cations was combined with the calcination to regulate the separate formation of various self-supported phases in order to target the multifunctional applicability as both hydrogen evolution reaction (HER) and OER in a simulated alkaline seawater. The OER’s metric current densities of 10 and 100 mA cm−2 were achieved at the bimetallic for only 1.60 and 1.63 VRHE, respectively. This high-performance was maintained in the electrolysis with a starting voltage of 1.6 V and satisfactory stability at 100 mA over 17 h. Our findings validate a high selectivity for OER of ~100%, which outperforms the previously reported data of 87–95%.
First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study

PURPOSE Nivolumab received US Food and Drug Administration approval as a single agent or in combination with ipilimumab in patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC) that progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan based on CheckMate 142. Presented are results of nivolumab plus low-dose ipilimumab in the first-line therapy cohort from the phase II CheckMate 142 study. PATIENTS AND METHODS Patients with no prior treatment in the metastatic setting for MSI-H/dMMR CRC were treated with nivolumab every 2 weeks plus low-dose ipilimumab every 6 weeks until disease progression. The primary end point was objective response rate (investigator assessment; RECIST v1.1). RESULTS Median age of treated patients was 66 years (N = 45). Median follow-up was 29.0 months. Objective response rate and disease control rate were 69% (95% CI, 53 to 82) and 84% (95% CI, 70.5 to 93.5), respectively, with 13% complete response rate. Median duration of response was not reached; 74% of responders had ongoing responses at data cutoff. Median progression-free survival and median overall survival were not reached with minimum follow-up of 24.2 months (24-month rates, 74% and 79%, respectively). Clinical benefit was observed regardless of baseline demographic and tumor characteristics, including BRAF or KRAS mutation status. In a post hoc analysis, of 14 patients who discontinued treatment and did not receive subsequent therapy, 10 remained progression-free. Patient-reported outcomes were stable over the treatment period. Grade 3-4 treatment-related adverse events occurred in 22% of patients; 13% discontinued because of any-grade treatment-related adverse events. CONCLUSION Nivolumab plus low-dose ipilimumab demonstrated robust and durable clinical benefit and was well tolerated as a first-line treatment for MSI-H/dMMR mCRC. Based on these promising data, randomized studies are warranted.
Audio-Tactile Rendering: A Review on Technology and Methods to Convey Musical Information through the Sense of Touch

Tactile rendering has been implemented in digital musical instruments (DMIs) to offer the musician haptic feedback that enhances his/her music playing experience. Recently, this implementation has expanded to the development of sensory substitution systems known as haptic music players (HMPs) to give the opportunity of experiencing music through touch to the hearing impaired. These devices may also be conceived as vibrotactile music players to enrich music listening activities. In this review, technology and methods to render musical information by means of vibrotactile stimuli are systematically studied. The methodology used to find out relevant literature is first outlined, and a preliminary classification of musical haptics is proposed. A comparison between different technologies and methods for vibrotactile rendering is performed to later organize the information according to the type of HMP. Limitations and advantages are highlighted to find out opportunities for future research. Likewise, methods for music audio-tactile rendering (ATR) are analyzed and, finally, strategies to compose for the sense of touch are summarized. This review is intended for researchers in the fields of haptics, assistive technologies, music, psychology, and human–computer interaction as well as artists that may make use of it as a reference to develop upcoming research on HMPs and ATR.
A Novel Green Preparation of Ag/RGO Nanocomposites with Highly Effective Anticancer Performance

The efficacy of current cancer therapies is limited due to several factors, including drug resistance and non-specific toxic effects. Due to their tuneable properties, silver nanoparticles (Ag NPs) and graphene derivative-based nanomaterials are now providing new hope to treat cancer with minimum side effects. Here, we report a simple, inexpensive, and eco-friendly protocol for the preparation of silver-reduced graphene oxide nanocomposites (Ag/RGO NCs) using orange peel extract. This work was planned to curtail the use of toxic chemicals, and improve the anticancer performance and cytocompatibility of Ag/RGO NCs. Aqueous extract of orange peels is abundant in phytochemicals that act as reducing and stabilizing agents for the green synthesis of Ag NPs and Ag/RGO NCs from silver nitrate and graphene oxide (GO). Moreover, the flavonoid present in orange peel is a potent anticancer agent. Green-prepared Ag NPs and Ag/RGO NCs were characterized by UV-visible spectrophotometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and dynamic light scattering (DLS). The results of the anticancer study demonstrated that the killing potential of Ag/RGO NCs against human breast cancer (MCF7) and lung cancer (A549) cells was two-fold that of pure Ag NPs. Moreover, the cytocompatibility of Ag/RGO NCs in human normal breast epithelial (MCF10A) cells and normal lung fibroblasts (IMR90) was higher than that of pure Ag NPs. This mechanistic study indicated that Ag/RGO NCs induce toxicity in cancer cells through pro-oxidant reactive oxygen species generation and antioxidant glutathione depletion and provided a novel green synthesis of Ag/RGO NCs with highly effective anticancer performance and better cytocompatibility.
Extreme sport as an intervention for physically injured military veterans: the example of competitive motorsport

Abstract Purpose Physically or psychologically injured military veterans are motivated and benefited by physical activity or sport that may involve high levels of achievement. The aim of this study was to provide an in-depth insight into the impact of Competitive Motorsport (CM) on physically injured/disabled veterans’ subjective well-being and in turn determine if it improves the quality of their lives. Methods This is a qualitative study. Two sets of semi-structured interviews were conducted with 14 male British military veterans including a 6-month follow-up. All participants were subjected to a permanent, moderate or severe, physical injury/disability. Data were analysed in accordance with the principles of Thematic Analysis. Results/Conclusions Five key elements (familiar environment, team spirit, adrenaline rush, competition and equality) made CM a unique experience for physically injured/disabled veterans. Various psychological and physical benefits were found, including an increased sense of accomplishment, opportunity to socialise in a non-clinical environment, embracement of body image and adoption of a healthier lifestyle. Since physical activity and sport are among growing research on alternative interventions for military veterans, they deserve serious consideration as part of the treatment regimens and rehabilitation programmes to improve physically inured/disabled veterans’ physical and mental health. Implications for Rehabilitation Competitive Motorsport is an effective means of improving physical health and subjective well-being of physically injured/disabled military veterans. Multiple perceived psychological and physical benefits were identified over time, including motivation for living, embracement of body image and adoption of a healthier lifestyle. Competitive Motorsport deserves consideration as part of the treatment regimens and rehabilitation programmes to improve physically injured/disabled veterans’ physical and mental health while facilitating transition to civilian life.