Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal cross-lagged analyses between cyberbullying perpetration, mindfulness and depression among Chinese high school students

The aim of this study is to examine the longitudinal relationships between cyberbullying perpetration, mindfulness, and depression among Chinese adolescents. The participants in our study included 1390 high school students who were randomly selected from several secondary schools in east China. Participants completed the Chinese version of Revised Cyber Bullying Inventory-Cyberbullying Subscale, the Chinese version of the Mindfulness Attention Awareness Scale and the Centre for Epidemiologic Studies Depression Scale for Children at two time points (6-month interval). The results found that cyberbullying, mindfulness and depression would predict each other over time. Contributions to theory, limitations in our research and recommendations for future intervention are discussed in this article.
Who Are the Stalking Victims? Exploring the Victimization Experiences and Psychosocial Characteristics of Young Male and Female Adults in Hong Kong

Most stalking studies are conducted in the West. Limited information is available on victims of stalking from the Asian continent. This study specifically explored the victimization experiences of young male and female adults in Hong Kong. Using a large sample of university students (N = 2,496) aged between 18 and 40 years, the gender distribution of stalking incident characteristics was examined, along with prevalence of various stalking behaviors, and victim–offender relationships by types of stalking behaviors. The differential role of demographic and psychosocial characteristics in stalking victimization experience was also explored. The lifetime prevalence rate of stalking victimization was 8.2%, with a higher estimate in females than males (11.6% vs. 3.8%). The sample analyzed in this study was 196 stalking victims. Although surveillance-oriented behaviors were most frequently reported by both males and females, significant gender differences in types of stalking behaviors were noted. Multivariate analyses indicated that increases in age and levels of self-esteem were correlated with an increased probability of experiencing stalking victimization, while being a male and higher levels of life satisfaction were related to a lower likelihood of falling prey to stalking victimization. This study concludes with a call for anti-stalking legislation in Hong Kong given the devastating nature and consequences of stalking victimization.
CPI-17 Overexpression and Its Correlation With the NF2 Mutation Spectrum in Sporadic Vestibular Schwannomas.

HYPOTHESIS We hypothesized that CPI-17 expression and NF2 mutations are correlated with merlin phosphorylation in the etiology of sporadic vestibular schwannoma (VS). BACKGROUND NF2 gene mutations have been identified in the majority of sporadic and NF2-associated schwannomas and NF2 gene mutations have been shown to result in merlin protein phosphorylation. CPI-17 can drive Ras activity and promote tumorigenic transformation by inhibiting the tumor suppressor merlin. The aim of this study was to determine the correlation between CPI-17 overexpression and the NF2 mutation spectrum in sporadic VS. METHODS In this study, we measured CPI-17 expression and identified NF2 gene alterations in a series of sporadic VS samples. Freshly frozen tumor and matched peripheral blood leukocytes from 44 individuals with sporadic VS were analyzed using next-generation sequencing and Sanger sequencing. Western blotting was used to determine the level of merlin phosphorylation, and immunohistochemistry and Western blotting were used to measure CPI-17 expression in the sporadic VS samples. CCK-8 and wound-healing assays were used to determine the influence of CPI-17 overexpression on cell proliferation. RESULTS NF2 mutations were identified in 79.5% of sporadic vestibular schwannomas, with all mutations being exclusively somatic. IHC and WB showed the expression of CPI-17 is upregulated in the sporadic VS. NF2 mutation and CPI-17 are positively correlated with merlin phosphorylation. CPI-17 overexpression induces the proliferation of HEI193 cells. CONCLUSION NF2 mutations and CPI-17 expression together induce merlin phosphorylation, which is correlated with the tumorigenesis of sporadic VSs.
Effects of Age at Auditory Brainstem Implantation: Impact on Auditory Perception, Language Development, Speech Intelligibility.

OBJECTIVE To study the effect of age at auditory brainstem implant (ABI) surgery on auditory perception, language, and speech intelligibility. STUDY DESIGN Retrospective single cohort design. SETTING Tertiary referral center. PATIENTS In this study, 30 pediatric ABI users with no significant developmental issues were included. Participants were divided into two groups, according to age at surgery (Early Group: < 3 yr old [n = 15], Late Group: ≥ 3 yr old [n = 15]). Groups were matched by duration of ABI use and participants were evaluated after 5 years (±1 yr) experience with their device. The mean age at ABI surgery was 22.27 (ranged ± 6.5) months in the early group, 45.53 (ranged ± 7.9) months in the late group. INTERVENTION(S) Retrosigmoid craniotomy and ABI placement. MAIN OUTCOME MEASURE(S) Auditory perception skills were evaluated using the Meaningful Auditory Integration Scale and Categories of Auditory Performance from the Children's Auditory Perception Test Battery. We used a closed-set pattern perception subtest, a closed-set word identification subtest, and an open-set sentence recognition subtest. Language performance was assessed with the Test of Early Language Development and Speech Intelligibility Rating, which was administered in a quiet room. RESULTS In this study, the results demonstrated that the Early Group's auditory perception performance was better than the Late Group after 5 years of ABI use, when children had no additional needs (U = 12, p < 0.001). Speech intelligibility was the most challenging skill to develop, in both groups. Due to multiple regression analysis, we found that auditory perception categories can be estimated with speech intelligibility scores, pattern perception scores, receptive language scores, and age at ABI surgery variables in ABI users with no additional handicaps. CONCLUSIONS ABI is a viable option to provide auditory sensations for children with cochlear anomalies. ABI surgery under age 3 is associated with improved auditory perception and language development compared with older users.
Neoadjuvant chemotherapy combined with interval cytoreductive surgery in ovarian cancer.

PURPOSE This study aimed to explore the value and prognosis-influencing factors for neoadjuvant chemotherapy combined with interval cytoreductive surgery in patients with advanced ovarian cancer. METHODS 178 patients were divided into the research group and control group. The research group was treated with neoadjuvant chemotherapy combined with interval cytoreductive surgery, while the control group underwent primary cytoreductive surgery alone. Postoperative situation, efficacy, progression-free survival (PFS) and overall survival (OS) were compared between the two groups of patients, and the postoperative influencing factors for the patients were analyzed. RESULTS The operation time, intraoperative blood loss and ascites volume in patients in the research group were shorter and lower than those in the control group (p<0.05). Univariate Cox regression analysis showed that the size of residual lesions after cytoreductive surgery, age, the International Federation of Gynecology and Obstetrics (FIGO) stage, the maximum primary tumor diameter and results of ascites cytological examination were the influencing factors for the OS of patients in the research group. The size of residual lesions after cytoreductive surgery, age and FIGO stage were independent factors affecting the postoperative OS of patients in the research group. CONCLUSION Administering neoadjuvant chemotherapy combined with interval cytoreductive surgery for patients with advanced ovarian cancer can reduce the operation time, intraoperative blood loss and ascites volume. Besides, the size of residual lesions after cytoreductive surgery, age and FIGO stage are independent factors affecting the postoperative OS of patients.
Nephrolithiasis in women: how different from men?

PURPOSE OF REVIEW Men have more kidney stones compared with women; however, the difference is progressively decreasing. The reasons for higher prevalence of stones in men, as well as increasing prevalence in women, is a subject of ongoing speculation. In this review, we summarize the evidence of differences between men and women and expand on the speculative causes. RECENT FINDINGS Stone incidence is rising in women and adolescent girls. Stone disease is more heritable among men than women, and women demonstrate greater influence of the unique environment. Women under the age of 50 years who have been pregnant, have more than double the odds of kidney stones compared with those who have never been pregnant. Women are more burdened with obesity, bariatric surgery and dieting, all associated with increased stones. Women have higher urinary pH because of greater absorption of dietary organic anions leading to increased urinary citrate, compared with men, and they differ in tubular calcium handling. SUMMARY It is obvious that the cause of stones in men and women is complex and requires further study. Potential clues offered are in the change of the female environment, influencing increasing incidence in stones, particularly of younger women and female adolescents.
Evaluation of Preliminary Phytochemical and Physicochemical Studies on Juniperus Communis L. Fruit Used In Ayurvedic Formulations

Plants are the great sources of medicines, especially in traditional system of medicine, which are useful in the treatment of various diseases. The recent global resurgence of interest in herbal medicines has led to an increase in the demand for them. Commercialization of these medicines to meet this increasing demand has resulted in a decline in their quality, primarily due to a lack of adequate regulations governing this sector of medicine. There is now a need to develop a systematic approach for the authentication of herbal plants and to develop well-designed methodologies for their standardization. The biological diversity in the Indian Himalayan Region especially in Kumaun Himalaya has been a source of medicine for millions in the country and elsewhere. Pharmacological Activities of Juniperus communis L. are diuretic, Anti-bacterial activity, Hepatoprotective and anti-hepatic cancer, Anti-fertility activity, Antiinflammatory, Effect on blood platelets, anti-tumor and anti-oxidant etc. The set parameters were found to be sufficient to evaluate the raw material and can be used as reference standards for the quality control/quality assurance purposes. The analysis and quality control of herbal medicines are moving towards an integrative and Comprehensive direction, in order to better address the inherent holistic nature of herbal medicines. In the present study, it was observed that all ingredients of commercial samples matched exactly with that of authentic standards after performing the standardization as per WHO guideline.
Professional Recognition At Work: The protective Role of Esteem, Respect and Care For Burnout Among Employees.

OBJECTIVE The present research systematically investigates the role of recognition experiences at work as a protective factor for burnout. METHOD In two cross-sectional studies (N = 328 and N = 220) with employees we measured via online questionnaires three forms of recognition (achievement-based social esteem, equality-based respect and need-based care) from coworkers and supervisors as predictors and burnout among employees as outcome. RESULTS Using multiple regression analyses, study 1 provided initial evidence that both supervisor and coworker recognition were negatively associated with employees' burnout. Study 2 further demonstrated that whereas respect experiences were especially crucial for lowering emotional exhaustion, care was primarily linked to reduced depersonalization and esteem to heightened personal accomplishment. CONCLUSION We discuss how positive recognition experiences can be fostered in organizations in order to buffer the negative effects burnout can cause.
Effects of chronic treatment with bupropion on self-administration of nicotine + cocaine mixtures in nonhuman primates.

Chronic health problems associated with long-term nicotine use are the leading cause of preventable death in the United States. The use of tobacco products is 3-4 times greater among individuals with cocaine use disorder than that observed in the general population. This may reflect the propensity of nicotine to augment the reinforcing effects of cocaine. However, the mechanism of action of nicotine differs from that of cocaine, which presents a significant challenge for the development of pharmacotherapeutic interventions for the management of nicotine + cocaine polydrug abuse. Bupropion, an FDA-approved smoking cessation aid, has pharmacological actions at both monoamine transporters and nicotinic receptors, suggesting that it may be effective at decreasing nicotine + cocaine coabuse. Here, rhesus monkeys (n = 4) responded for food pellets and, separately, intravenous injections of nicotine, cocaine, or nicotine + cocaine mixtures under a second-order FR2(VR16:S) schedule of reinforcement during 7- to 10-day continuous treatment with saline or bupropion (1.0 and 1.8 mg/kg/hr). Results show that bupropion treatment dose-dependently decreased self-administration of nicotine combined with a low dose of cocaine (0.0032 mg/kg/inj); however, when the dose of cocaine in the mixture was higher (i.e., 0.01 mg/kg/inj), bupropion attenuated self-administration in only a subset of subjects. The effective dosage of bupropion increased responding for cocaine alone, nicotine alone, and for saline injections and significantly increased measures of daily activity. The apparent stimulant-like effects of bupropion at the dosage required to decrease cocaine + nicotine self-administration does not support its clinical use for the management of nicotine + cocaine polydrug abuse. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
MRI EVALUATION OF THE SYSTEMIC - PULMONARY ARTERIAL SHUNTS IN PATIENTS WITH PULMONARY ARTERY STENOSIS OR COMPLEX PULMONARY ARTERY ATRESIA

Poster: "ECR 2011 / C-2028 / MRI evaluation of the systemic-pulmonary arterial shunts in patients with pulmonary artery stenosis or complex pulmonary artery atresia. " by: "D. L. Radu1, R. Lesanu1, R. A. Capsa1, I. G. Lupescu1, S. A. Georgescu2; 1Bucharest/RO, 2Sector 2/RO"
Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells

Semaphorin 5A (SEMA5A), a member of the semaphorin family, plays an important role in axonal guidance. Previously, the authors identified another possible role of SEMA5A as a prognostic biomarker for non-smoking women with lung adenocarcinoma in Taiwan, and this phenomenon has been validated in other ethnic groups. However, the functional significance of SEMA5A in lung adenocarcinoma remains unclear. Therefore, we assessed the function of SEMA5A in three lung adenocarcinoma cell lines in this study. Kaplan-Meier Plotter for lung cancer was conducted for survival analyses. Reverse transcription-quantitative PCR (RT-qPCR) and western blot analysis were performed to investigate the expression and post-translational regulation of SEMA5A in lung adenocar-cinoma cell lines. A pre-designed PyroMark CpG assay and 5-aza-2′-deoxycytidine treatment were used to measure the methylation levels of SEMA5A. The biological functions of lung adenocarcinoma cells overexpressing SEMA5A were investigated by microarrays, and validated both in vitro (proliferation, colony formation and migration assays) and in vivo (tumor xenografts) experiments. The results revealed that the hypermethylation of SEMA5A and the cleavage of the extracellular domain of SEMA5A were responsible for the downregulation of the SEMA5A levels in lung adenocarcinoma cells (A549 and H1299) as compared to the normal controls. Functional analysis of SEMA5A-regulated genes revealed that they were involved in cellular growth and proliferation. The overexpression of SEMA5A in A549 and H1299 cells significantly decreased the proliferation (P<0.01), colony formation (P<0.001) and migratory ability (P<0.01) of the cells. The suppressive effects of SEMA5A on the proliferative and migratory ability of the cells were also observed in both in vitro and in vivo experiments using brain metastatic Bm7 lung adenocarcinoma cells. On the whole, the findings of this study suggest a suppressive role for SEMA5A in lung adenocarcinoma involving the inhibition of the proliferation and migration of lung transformed cells.
Risk of Diabetes Mellitus in Patients with Juvenile Idiopathic Arthritis

Objective. To examine the risk of type 1 diabetes (T1D) associated with juvenile idiopathic arthritis (JIA). Methods. Using the IBM MarketScan database, we compared JIA patients with asthma patients and healthy individuals for the risk of incident T1D. Results. We included patients with 15,210 JIA, 76,050 patients with asthma, and 76,050 healthy individuals matched 1:5 on age, sex, and index date. After adjustment for confounders, the multivariable HR of T1D associated with JIA was 1.48 (95% CI 0.86–2.56) versus asthma and 1.81 (95% CI 1.03–3.17) versus healthy individuals. Conclusion. JIA appears to be associated with an increased risk of T1D compared to patients with asthma and healthy children.
First report of pre-Hispanic Fasciola hepatica from South America revealed by ancient DNA

Abstract It is generally assumed that the digenean human liver fluke, Fasciola hepatica, gained entry to South America during the 15th century upon arrival of Europeans and their livestock. Nonetheless in Patagonia, Argentina, digenean eggs similar to F. hepatica have been observed in deer coprolites dating back to 2300 years B.P. The main objective of our present study was to identify and characterize these eggs using an ancient DNA (aDNA) study. Eggs were isolated and used for aDNA extraction, amplification and sequencing of partial regions from the cytochrome c oxidase subunit 1 and the nicotinamide adenine dinucleotide dehydrogenase subunit 1 mitochondrial genes. Also, phylogenetic trees were constructed using Bayesian and maximum likelihood. Our results confirm the presence of F. hepatica in South America from at least 2300 years B.P. This is the first report and the first aDNA study of this trematode in South America prior to the arrival of the European cattle in the 15th century. The present work contributes to the study of phylogenetic and palaeobiogeographical aspects of F. hepatica and its settlement across America.
Differences in Flow-Gradient Patterns Between Severe Bicuspid Aortic Stenosis and Severe Tricuspid Aortic Stenosis　- Mechanistic Insight From Multimodal Imaging.

BACKGROUND We investigated the flow-gradient pattern characteristics and associated factors in severe bicuspid aortic stenosis (AS) compared with severe tricuspid AS.Methods and Results:A total of 252 patients with severe AS (115 bicuspid vs. 137 tricuspid) who underwent aortic valve (AV) replacement were retrospectively analyzed. Patients were classified into 4 groups according to stroke volume index and mean pressure gradient across the AV [normal-flow-high-gradient (NF-HG), low-flow-high-gradient, normal-flow-low-gradient, low-flow-low-gradient (LF-LG)]. In 89 patients who underwent cardiac computed tomography (CT), influential structural parameters of the left ventricular outflow tract (LVOT), AV and ascending aorta were assessed. Bicuspid AS was more likely to present a NF-HG pattern (83.5% vs. 64.2%, P<0.001), and significantly fewer presented a LF-LG pattern compared with tricuspid AS. In bicuspid AS, there was a significant mismatch between geometric orifice area (GOA) on CT planimetry and effective orifice area (EOA) calculated using the echocardiographic continuity equation. Bicuspid AS presented with a larger angle between the LVOT-AV and aorta. Multivariate analysis of bicuspid AS revealed that systemic arterial compliance (β=-0.350, P=0.031) and the LVOT-AV-aorta angle (β=-0.538, P=0.001), and stroke volume index (β=0.409, P=0.008) were associated with a discrepancy between GOA and EOA. CONCLUSIONS Flow-gradient patterns in bicuspid AS differ from those of tricuspid AS and are associated with the structural and functional characteristics of the aorta.
Community-based Memory Screening Intervention and Memory Knowledge in Older Adults

DEDICATION To all those affected by Alzheimer's disease. v ACKNOWLEDGEMENTS I would like to thank my advisor, Rebecca Ready, for her many years of mentorship and support. Thank you also to Michael Constantino, Christopher Overtree, and Joseph Mangine. Together, their friendship and contributions to my professional development have meant the world to me. I wholeheartedly thank all of my mentors and clinical supervisors throughout my time at UMass, all of whom have helped me get to this point. I would also like to express gratitude to the members of my committee, Linda Isbell and Cynthia Jacelon, for their guidance and suggestions throughout all stages of this project. I would like to specially thank all individuals who participated in this project, particularly the study participants. Their time and stories inspired me and kept me going. Thank you to my mom, dad, brother, and all of my family and friends who have been there for me every step of the way and whose friendship, support, and love enabled me to complete this project. As the United States' population ages, there is a growing need for older adults to screen for age-related memory problems. Four theoretically-derived psychosocial factors are predictive of dementia screening intention: perceived benefits, perceived susceptibility, self-efficacy, and knowledge about aging memory. The current study preliminarily tested whether these factors could be increased with a community-based, educational memory screening intervention. Educational presentations were offered at community senior centers and data on psychosocial factors and willingness to screen were collected pre-and post-presentation from 32 older adult participants (age M = 78.69, SD = 7.12). Perceived benefits and self-efficacy significantly increased from pre-to post-presentation p < . 01, partial η 2 = . 20). The majority of participants (75%) signed up for memory screens following the presentation. Participants had generally high satisfaction ratings and positive narrative responses about the presentation. Results provide information about how the presentation can be refined to address psychosocial factors and determine if these factors impact willingness to screen for memory. This feasibility and efficacy vii study represents a step to raising knowledge and awareness of memory and aging issues among older adults in the community.
Early response evaluation during preoperative chemotherapy for colorectal liver metastases: Combined size and morphology‐based criteria predict pathological response and survival after resection

Short treatment‐duration with early restaging is crucial to avoid liver injury after preoperative chemotherapy (preopCTX) for colorectal liver metastases (CRLM). Response evaluation according to response evaluation criteria in solid tumors (RECIST) criteria implies several limitations. Early tumor shrinkage (ETS; ≥20% size reduction <6‐12 weeks) or morphological criteria (MC) may better predict oncological outcome.