Miracle-dz/UniFAR-FTUs huggingface dataset:
Antimicrobial susceptibility pattern of oral viridans group Streptococci in children at risk of infective endocarditis

Infective endocarditis (IE) is an important clinical disease in children with a mortality rate of 11.6%. Prophylaxis with antibiotics is one of the most commonly used methods in children at risk of IE; therefore, the evaluation of antibiotic resistance seems necessary in view of its increasing trend. This study aimed to determine the antibiotic susceptibility pattern of oral viridans group streptococci (VGS) isolated from the dental plaque of children at risk of IE. Fifty-one plaque samples were obtained from children aged 3 to 12 years old in the period from April to July 2018. Samples were obtained with sterile swabs and were transferred to the laboratory in Brain Heart Infusion (BHI) Broth. Samples were immediately cultivated on Columbia blood agar. After identifying VGS, antimicrobial susceptibility test (AST) was performed using Mueller-Hinton agar (MHA) with sheep's blood and E-test strips for selected antibiotics. The minimum inhibitory concentration (MIC) was determined for each isolate and the results were reported as sensitive, intermediate and resistant. Fifty-one VGS bacteria were isolated from children with an average age of 7.3 ± 2.5 years. The highest resistance was observed for azithromycin in 36 (70.6%) isolates and then cefazolin in 35 (68.6%) isolates. The highest susceptibility was observed for amoxicillin in 46 (90.2%) isolates. Based on the findings of this study, amoxicillin is the most effective option for prophylaxis in children. Furthermore, cefazolin should be used with caution because bacteria resistant to this antibiotic can transfer resistance genes to other bacteria.
THE EFFECT OF USING POWTOON TOWARD STUDENTS’ MOTIVATION IN WRITING

This research was done due to the lack of students' motivation in writing in MTsN 1 Agam. To find out whether there was a significant effect of using Powtoon toward students' motivation in writing, the hypothesis was formulated. This quantitative research was classified into experimental research. The sampling technique used in this research was cluster random sampling. Two groups were selected as the sample of the research that was separated into experimental group and control group. There were 37 students as the respondents in the experimental group and 34 students as the respondents in the control group. The experimental class was taught by using Powtoon as media in teaching and the control group was taught only by using an English book. The result of paired sample t-test showed that the obtained (4,722) was higher than ttable (2,028) for the degree of freedom 36 with the level significant 0,025. The null hypothesis was rejected and the alternative hypothesis was accepted. It means there is a significant effect of using Powtoon toward students' motivation in writing at the eighth grade of MTsN 1 Agam. The researcher proved that the Powtoon as a media was able to increase students' motivation in writing.
CMAR_A_285002 45..53

*These authors contributed equally to this work Background: Multi-kinase inhibitors (MKIs) treatment plays an important role in cancer therapy, but still suffers from a high incidence of hand–foot skin reaction (HFSR), leading to MKIs dose modification or termination. Thus, there is a high need for therapeutic strategy for HFSR. Patients and Methods: This prospective analysis included twenty patients, who were continuously administered with MKIs treatment and presented with a grade 3 HFSR during January 2018 to December 2019. All the patients were treated with the Shouzu Ning Decoction (SND) twice a day, in addition to the MKIs treatment. Grading of HFSR was assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. Pain intensity was evaluated using the numerical rating scale (NRS). Quality of life was assessed using the Hand–Foot Quality of Life Scale (HF-QoLS). Results: The median time from MKIs initiation to onset of grade 3 HFSR was 26.2 days. Following the SND treatment, seventeen (17/20) patients displayed grade 2 HFSR with a median time of 5.1 days. Among whom, seven (7/17) finally transformed to grade 1 with a median time of 9.9 days. While all of the grade 1 patients (7/7) had local recurrence, and retreatment of the SND was effective. In addition, after the SND treatment, the score of NRS and HF-QoLS decreased to 1.60 ± 1.14 (P < 0.01) and 26.75 ± 11.76 (P < 0.01), respectively. Conclusion: The SND treatment could alleviate symptoms, relieve pain and improve quality of life in HFSR patients. The SND treatment was proved to be an effective and welltolerated treatment for MKIs-associated grade 3 HFSR patients for the first time. Indeed, further randomized controlled trails with large-scale, multi-center are require to fully determine the clinical application of the SND in MKIs-associated HFSR.
Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration

1. National Institute of Genetic Engineering and Biotechnology, Tehran, Iran. 2. Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Department of Ophthalmology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Blood Transfusion Research Center, High Institute for Research & Education in Transfusion Medicine, Tehran, Iran. 5. Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Department of Pathology and Molecular Medicine, Queen's University, Kingston, Canada. 7. Department of Clinical Biochemistry-Biophysics and Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Effect of losartan on hospitalized patients with COVID-19-induced lung injury: A randomized clinical trial

Background: SARS-CoV-2 viral entry may disrupt angiotensin II (Ang II) homeostasis in part via ACE2 downregulation, potentially contributing to COVID-19 induced lung injury. Preclinical models of viral pneumonias that utilize ACE2 demonstrate Ang II type 1 receptor (AT1R) blockade mitigates lung injury, though observational COVID-19 data addressing the effect of AT1R blockade remain mixed. Methods: Multicenter, blinded, placebo-controlled randomized trial of losartan (50 mg PO twice daily for 10 days) versus placebo. Hospitalized patients with COVID-19 and a respiratory sequential organ failure assessment score of at least 1 and not already taking a renin-angiotensin-aldosterone system (RAAS) inhibitor were eligible. The primary outcome was the imputed partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) ratio at 7 days. Secondary outcomes included ordinal COVID-19 severity, oxygen, ventilator, and vasopressor-free days, and mortality. Losartan pharmacokinetics (PK) and RAAS components [Ang II, angiotensin-(1-7) (Ang-(1-7)), ACE, ACE2] were measured in a subgroup of participants. Findings: From April 2020 - February 2021, 205 participants were randomized, 101 to losartan and 104 to placebo. Compared to placebo, losartan did not significantly affect PaO2/FiO2 ratio at 7 days [difference of -24.8 (95% -55.6 to 6.1; p=0.12)]. Losartan did not improve any secondary clinical outcome, but worsened vasopressor-free days. PK data were consistent with appropriate steady-state concentrations, but we observed no significant effect of losartan on RAAS components. Interpretation: Initiation of orally administered losartan to hospitalized patients with COVID-19 and acute lung injury does not improve PaO2 / FiO2 ratio at 7 days. These data may have implications for ongoing clinical trials.
Differentials and determinants of immunization coverage among children aged 12-36 months in India: Analysis of nationally-representative, population-based survey data

Introduction Immunization coverage among children is still a major public health concern in India and other low-middle income countries. Low coverage likely risks the health of children and therefore impacts their overall growth. We therefore examined the immunization coverage rates among children aged 12-36 months in India and its states. We also explored the associated factors affecting immunization coverage among children aged 12-36 in India. Methods We used data from 75th round of the National Sample Survey Organizations (NSSO), collected from July 2017 to June 2018. The analytical sample of children aged 12-36 months information cases was 15887. Immunization coverage rates of India and its states were calculated. We evaluated the immunization coverage rate by background characteristics in India and its states. We performed multinomial logistic regression analysis to estimate the factors associated with the immunization coverage in India. Results About 61.95% were fully immunized, 35.62% were partially immunized and the rest 2.43% had not received any vaccine. The children aged 21-28 months (0.50; p<0.01) & 29-36 months (0.35; p<0.01), belonging to North-Eastern regions (0.60; p<0.01) were found to be significantly less likely to receive fully immunization. Likewise, urban children are (1.26; p<0.1) found to be more likely to receive fully immunization. The lowest fully immunization has been seen in Daman and Diu (1.73%) followed by Nagaland (6.93%), NCT Delhi (34.71%), and Tripura (46.33%). Conclusions Child immunization is a key public health concern and vital challenge to be addressed. Socio-economic characteristics play a key role in immunization coverage. Therefore necessary policy measures must be taken to address the challenges of poor immunization coverage and its impact on health and wellbeing of children Keywords: fully immunization; partial immunization; child health; immunization coverage.
Does Corporate Governance Matter for Politically Connected Firms? — Evidence from the Regime Change in Malaysia

We examine the role that corporate governance plays in moderating the association between political connections and firm value when an unexpected but peaceful shift in political power takes place. Using the 2018 general election in Malaysia as our event, we find that the stock market reacts positively (negatively) to politically connected firms (PCFs) that are connected to the winning (losing) coalition. Further investigation reveals that market reactions take into account the corporate governance of these connected firms. Our results highlight the importance of corporate governance across PCFs as a hedge when such connections can be detrimental to firm value.
Determinants and Consequences of Student Learning Satisfaction During Covid-19 Pandemic

This study examines the effect of student perception in online learning on student satisfaction and its impact on student learning performance and intention to use in the future. The regression analysis method was used based on the survey results from 157 students. Results indicate that students' perceptions of online learning had a positive effect on student satisfaction, intention to use, and student learning performance. Further, student satisfaction has a positive effect on student learning performance but does not affect the intention to use. The implications for lecturers, students, and faculties are also discussed.
Detection of Rifampicin Mono-Resistant Mycobacterium Tuberculosis by Genexpert in Patients Attending Tertiary Care Teaching Hospital

Original Research Article In India incidence of TB is 27, 90,000, mortality is 4, 23,000 and incidence of MDRTB/RR 1, 47,000. Early detection of TB is the key to successful treatment and reduction of disease transmission. The aim of this study is to determine the Rifampicin resistant, Mycobacterium tuberculosis by Gene Xpert in patient attending TB chest hospital, Hyderabad. All the Samples, Pulmonary and Extra pulmonary, received from clinically suspected cases of Tuberculosis, IP and OP during the study period between March 2018 to October 2018 were processed in the department of Microbiology using Xpert MTB/RIF test version 4.8 (Cepheid) as per the manufacturer’s instruction. Result: Prevalence of total MTB culture positive was 34.2 % (754/2202) and Rifampicin resistant was 13.7 % (103/754) in the total samples processed. Conclusion: Early detection of TB is the key to successful treatment and reduction of disease transmission. Gene Xpert was found to be useful assay for rapid detection of MTB within 2 hours with additional advantage of identifying Rifampicin resistance with high sensitivity and specificity.
Leadership style and employee readiness: Basic factors of leadership efficiency

The scope of this study is based on the Situational Leadership Theory according to the model created by Hersey and Blanchard, predominantly defined by two research sub-fields: leadership style and readiness of employees. This model distinguishes four different leadership styles, while the subject area of readiness of employees comprises two components: readiness of employees based on the competency component and readiness of employees based on a psychological (motivational) component. The subject matter of the study is to identify leadership style as a new variable which will be utilized for determining the interdependence with leadership efficiency levels and readiness of employees. Leadership efficiency is determined by the degree of compatibility between the dominant style of leadership and the level of readiness of employees. In addition to the main objective of the research, aimed at determining leadership efficiency, significant research findings come as a result of specific objectives. That is impact of the dominant leadership style on readiness of employees and leadership results, based on each specific component. The sample will be a random sample from a finite population of units, with repeated sampling and known probability sampling. A sample of size n=100, with a proportion of 0.10, is based on a list of top 100 biggest companies in the Republic of Serbia in 2019. The application of Principal Component Analysis aims to identify new variables in the form of regression coefficient results, while the application of the hierarchical regression model will help determine the impact of each leadership style on readiness of employees. The study findings confirm the basic hypotheses of the aforementioned model, with regard to the results of leadership efficiency, as well as its impact of each leadership style on readiness of employees.
Corrosion Inhibition Effects and Adsorption Characteristics of Ethanol Extract of King Bitters Root (Andrographis paniculata) on Mild Steel in Hydrochloric and Tetraoxosulphate (VI) Acid Media

The corrosion inhibition performance of ethanol extract of Andrographis paniculata (King Bitter) root (EEAPR) on the corrosion of Mild Steel (MS) in 1.0 M HCl and H 2 SO 4 acid solutions at 303K and elevated temperatures of 313, 323 and 333K was investigated and compared. The experimental work was performed by the use of weight loss and hydrogen evolution techniques. The results indicate that the extract inhibit the corrosion of mild steel in both acid media. However, the EEAPR exhibits higher maximum inhibition efficiency of 98.9 % in HCl than in H 2 SO 4 (95.0 %) at 5.0 g/L. Inhibition efficiency was found to increase with increasing concentration of extract in both acid media but decreased with rise in temperature. Inhibition mechanism was deduced from the temperature dependence of the inhibition efficiency as well as from activation parameters that govern the process. Adsorption of extract on the MS sample in both acid media was found to obey the Langmuir adsorption isotherm. The phenomenon of physical adsorption is proposed from the obtained thermodynamic parameters.
Reply to Comment on ‘Electrostatic potential of a uniformly charged triangle in barycentric coordinates’

Motivated by the comment on our paper (2021 Eur. J. Phys. 42 045205) made by Ferreira D R, we carry out a comprehensive numerical comparison of the three known analytic expressions for the electrostatic potential of a uniformly charged triangle sheet. We report that the three expressions are equivalent to one another.
Peripartum Hysterectomy due to Placenta Accreta Spectrum Disorders-Improved Maternal and Neonatal Morbidity after Diagnostic Ultrasound and Multidisciplinary Care

Introduction: The increasing Cesarean Section (CS) rate worldwide is followed by increased maternal morbidity due to Placenta Accreta Spectrum (PAS) disorders. The objective was to evaluate the rate of CS with Peripartum Hysterectomy (PPHE) due to advanced PAS disorders during the years 2008-18. Furthermore, we compared the rates of antenatal detection and planned surgery, as well as maternal and neonatal morbidity. between the two periods 2008-15 and 2016-18, before and after the introduction of diagnostic ultrasound in women at increased risk of PAS disorders at 2nd trimester ultrasound and multidisciplinary care in cases of advanced PAS disorders in need of CS with PPHE. Material and Methods: A retrospective cohort study at a tertiary university hospital in Sweden. All women (n=17) in 2008-15 and (n=19) in 2016-18 who underwent CS with PPHE due to advanced PAS disorders were included. Results: The rate of CS with PPHE due to advanced PAS disorders increased from 0.7 to 2.2 per 10,000 deliveries during 2008-18. Antenatal detection increased from 70% to 95% (p=0.05) and planned surgery from 53% to 84% (p=0.02) between the two periods 2008-15 and 2016-18. Perioperative blood loss decreased from 6-2 L (p=0.01), erythrocyte transfusion from 12-3 U (p=0.007), and composite maternal morbidity from 88% to 12% (p=0.001). The rate of newborns with birth weight <2500 g decreased from 58% to 21% (p=0.02), Apgar score <7 at 5 min from 58% to 31% (p=0.05) and umbilical artery base excess BE(a) less than -10 mmol/L from 16% to 0% (p=0.05). Conclusion: The rate of CS with PPHE due to advanced PAS disorders increased three-fold. The introduction of diagnostic ultrasound and multidisciplinary care was followed by increased rates of antenatal detection and planned surgery, and evident improvements in maternal and neonatal morbidity. We suggest diagnostic ultrasound in women at increased risk of PAS disorders and centralized high-risk obstetrics with multidisciplinary care in cases of advanced PAS disorders.
Conversational Survey Chatbot: User Experience and Perception

: The aim of the paper is to explore two directions, one is the use of conversational chatbots for the purpose of data collection, and the other is the analysis of user experience in the usage of chatbots when it comes to various customer services. Regarding survey chatbot, the paper discusses existing obstacles of static online surveys, and through the presented steps of chatbot design, demonstrated the ease of designing and distributing chatbot for research purposes. On the other hand, through the conducted research, which included 200 respondents from the Serbian market, research shows that chatbots are not so widely used (only 44% have used chatbot), and even 88% of respondents would use human rather than Chabot. However, through analysis of existing research that involved other markets, results have shown that most respondents feel more relaxed and have fun when using a chatbot. Still, the main obstacle, in general, is the lack of social capabilities of chatbots.
Can high transverse skin incision (Modified Maylard) be a new alternative in placenta accreta spectrum management with cesarean hysterectomy?

Background: Assess optimal surgical management of cases with placenta accreta spectrum (PAS) disorder. Methods: This was a retrospective study conducted between January 2012 and November 2020. Two alternative types of incision were performed in patients diagnosed with PAS. (1) A high transverse skin incision, 12–14 cm in length, was performed through the skin 5–8 cm above the pubic symphysis. (2) A vertical skin incision was made from the xiphoid process to the pubic symphysis, passing around the umbilicus. We compared intraoperative and postoperative outcomes of both types of incisions in patients undergoing caesarean hysterectomy. The aesthetic appearance of the scar was assessed using the scar cosmesis assessment and rating (SCAR) scale. Results: Forty-four placenta accreta spectrum patients were evaluated. No differences were observed between the skin incision groups regarding exploration and surgical manipulation. Lengths of hospitalization and operative times were less in patients undergoing high transverse skin incision compared to vertical incision (5.5± 1.1, 8.0± 1.1, p = 0.03; respectively). Wound site complications were lower in high transverse skin incision patients. Patients in the high transverse incision group had significantly better SCAR scores than patients in the vertical incision group (3.3± 0.9 vs 11.4 ± 1.8; p < 0.001) and a significantly higher proportion in the high transverse incision group were very satisfied or satisfied with the cosmetic aspects of the scar (p = 0.001). Conclusion: The high transverse incision method in women with PAS is a better method of skin incision giving reduced operative and hospitalisation times and improved cosmetic outcomes.
Impact of Capital Market Development on Economic Growth in Nigeria

This study appraised the impact of capital market development on economic growth in Nigeria between 1990 and 2015. The study used Gross Domestic Product as the dependent variable and also used foreign direct investment, government expenditure, market capitalization, all share index, number of transactions, credit to private sector and stock turnover ratio as independent variables coupled with the use of the Auto Regressive Distributed Lag (ARDL) model and Granger Causality technique revealing that capital market development has positive effect on economic growth. Hence, it is recommended that participation within the market should be encouraged as various entities within the economy should be encouraged to invest in the capital market through various incentives in a bid to spur economic growth
Oral contraception use in BRCA gene mutation carriers: information for counselling in routine clinical practice

Department of Obstetrics and Gynecology, IRCCS San Matteo Foundation, 27100 Pavia, Italy Department of Medical Oncology, IRCCS San Matteo Foundation, 27100 Pavia, Italy General Surgery III, Breast Surgery, Department of Surgery, IRCCS San Matteo Foundation, 27100 Pavia, Italy Centre for Inherited Diseases, IRCCS San Matteo Foundation, 27100 Pavia, Italy Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, 27100 Pavia, Italy
Skills mismatch in the labor market: The future of work from the viewpoint of enterprises in case of Kosovo

How to cite this paper: Ziberi, B. , Rexha, D. , & Ukshini, K. (2021). Skills mismatch in the labor market: The future of work from the viewpoint of enterprises in case of Kosovo. Journal of Governance & Regulation, 10(3), 104–116. https://doi.org/10.22495/jgrv10i3art9 Copyright © 2021 The Authors This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). https://creativecommons.org/licenses/by/