Miracle-dz/UniFAR-FTUs huggingface dataset:
Retrospective Data Analysis of Patients With Metastatic Lung Adenocarcinoma With or Without KRAS-Mutation or TTF1-Expression

Introduction Patients with lung adenocarcinoma not expressing TTF1 and those with a KRAS mutation have worse prognosis. However, available data are limited and sometimes contradictory. Therefore, this retrospective cohort analysis aimed to clarify whether there was a difference in overall survival and progression-free survival between these groups of patients. Methods In total, data derived from 181 patients with metastatic lung adenocarcinoma treated at the Martha-Maria Halle-Dölau Hospital from 2016 to 2019 were analyzed. Kaplan-Meier curves were generated, and associated values, such as median survival and its confidence intervals, were determined using the log-rank test. Results A benefit in overall survival (OS) (8.4 vs 5.8 months; HR, .8; 95% CI, .53-1.19; P = .267) was associated with positive TTF1 expression, but this was not statistically significant. The same trend was shown with the progressive free survival (PFS) (6.5 vs 4.6 months; HR, .76; 95% CI, .51-1.20; P = .162). In patients with a KRAS mutation, there was no difference in OS compared to those with a wildtype KRAS. The median survival was almost identical at 7.5 months (KRAS mutation, 95% CI, 3.32-11.74) and 7.0 months (KRAS wildtype, 95% CI, 3.59-10.41). Additionally, in PFS, there was no difference between the 2 groups (5.8 vs 6.3 months). Conclusions Our analysis did not show a worse prognosis in patients with a KRAS mutation or in those with missing TTF1 expression, which is most likely related to the new therapeutic options. As a result of the administration of immunotherapy in patients with a KRAS mutation and the change from a regimen containing pemetrexed to a regimen containing no pemetrexed, the corresponding patients no longer seem to have a worse prognosis.
Curing CLL: one clone at a time

In this issue of Blood Advances, Naeem et al provide evidence that pirtobrutinib targets ibrutinibresistant chronic lymphocytic leukemia (CLL) that harbors pathological Bruton’s tyrosine kinase (BTK) C481S-mutant. However, concomitant with disease progression (DP), non-C481 variants of BTK with or without gatekeeper T474 mutants have emerged, rendering pirtobrutinib ineffective in mitigating the B-cell receptor (BCR) signaling cascade.
Cosmological perturbations in unimodular gravity

We study cosmological perturbation theory within the framework of unimodular gravity. We show that the Lagrangian constraint on the determinant of the metric required by unimodular gravity leads to an extra constraint on the gauge freedom of the metric perturbations. Although the main equation of motion for the gravitational potential remains the same, the shift variable, which is gauge artifact in General Relativity, cannot be set to zero in unimodular gravity. This non-vanishing shift variable affects the propagation of photons throughout the cosmological evolution and therefore modifies the Sachs-Wolfe relation between the relativistic gravitational potential and the microwave temperature anisotropies. However, for adiabatic fluctuations the difference between the result in General Relativity and unimodular gravity is suppressed on large angular scales. Thus, no strong constraints on the theory can be derived.
LATE-TIME OPTICAL EMISSION FROM CORE-COLLAPSE SUPERNOVAE

Ground-based optical spectra and Hubble Space Telescope images of 10 core-collapse supernovae (CCSNe) obtained several years to decades after outburst are analyzed with the aim of understanding the general properties of their late-time emissions. New observations of SN 1957D, 1970G, 1980K, and 1993J are included as part of the study. Blueshifted line emissions in oxygen and/or hydrogen with conspicuous line substructure are a common and long-lasting phenomenon in the late-time spectra. Followed through multiple epochs, changes in the relative strengths and velocity widths of the emission lines are consistent with expectations for emissions produced by interaction between SN ejecta and the progenitor star's circumstellar material. The most distinct trend is an increase in the strength of [O iii]/([O i]+[O ii]) with age, and a decline in Hα/([O i]+[O ii]) which is broadly consistent with the view that the reverse shock has passed through the H envelope of the ejecta in many of these objects. We also present a spatially integrated spectrum of the young Galactic supernova remnant Cassiopeia A (Cas A). Similarities observed between the emission line profiles of the ≈330 yr old Cas A remnant and decades old CCSNe suggest that observed emission line asymmetry in evolved CCSN spectra may be associated with dust in the ejecta, and that minor peak substructure typically interpreted as “clumps” or “blobs” of ejecta may instead be linked with large-scale rings of SN debris.
Compositionally-modulated Si1-xGex multilayers with cross-plane thermal conductivity below the thin-film alloy limit

We describe epitaxial Ge/Si multilayers with cross-plane thermal conductivities which can be systematically reduced to exceptionally low values, as compared both with bulk and thin-film SiGe alloys of the same average concentration, by simply changing the thicknesses of the constituent layers. Ab initio calculations reveal that partial interdiffusion of Ge into the Si spacers, which naturally results from Ge segregation during growth, plays a determinant role, lowering the thermal conductivity below what could be achieved without interdiffusion (perfect superlattice), or with total interdiffusion (alloy limit). This phenomenon is similar to the one previously observed in alloys with embedded nanoparticles, and it stresses the importance of combining alloy and nanosized scatterers simultaneously to minimize thermal conductivity. Our calculations thus suggest that superlattices with sharp interfaces, which are commonly sought but difficult to realize, are worse than compositionally-modulated Si1-xGex multilayers in the search for materials with ultralow thermal conductivities.
[C II] and [N II] from dense ionized regions in the Galaxy

The interstellar medium (ISM) consists of highly ionized and neutral atomic, as well as molecular, components. Knowledge of their distribution is important for tracing the structure and lifecycle of the ISM. Here we determine the properties of the highly ionized and neutral weakly ionized gas in the Galaxy traced by the fine-structure lines of ionized nitrogen, [N II], and ionized carbon, [C II]. To analyze the ionized ISM we utilize [C II] 158 micron and [N II] 205 micron lines taken with the high spectral resolution Heterodyne Instrument in the Far-Infrared (HIFI) on the Herschel Space Observatory along ten lines of sight towards the inner Galaxy. [N II] emission can be used to estimate the contribution of the highly ionized gas to the [C II] emission and separate the highly ionized and weakly ionized neutral gas. We find that [N II] has strong emission in distinct spectral features along all lines of sight associated with strong [C II] emission. The [N II] arises from moderate density extended HII regions or ionized boundary layers of clouds. Comparison of the [N II] and [C II] spectra in 31 separate kinematic features shows that many of the [C II] spectra are affected by absorption from low excitation gas associated with molecular clouds, sometimes strongly so. The apparent fraction of the [C II] associated with the [N II] gas is unrealistically large in many cases, most likely due to the reduction of [C II] by absorption. In a few cases the foreground absorption can be modeled to determine the true source intensity. In these sources we find that the foreground absorbing gas layer has C$^+$ column densities of order 10$^{18}$ cm$^{-2}$. [C II] emission arising from strong sources of [N II] emission is frequently absorbed by low excitation foreground gas complicating the interpretation of the properties of the ionized and neutral gas components that give rise to [C II] emission.
Recognition and attitudes of Korean physicians toward fecal microbiota transplantation: a survey study

Background/Aims Fecal microbiota transplantation (FMT) represents a treatment option for recurrent Clostridioides difficile infection (CDI). Recently, FMT has been investigated in various clinical settings other than CDI. This study examined Korean physicians’ recognition of FMT and their attitudes toward this procedure Methods An online questionnaire included questions on indications for FMT, the FMT process, physicians’ attitudes toward FMT for the treatment of CDI and non-CDI diseases, and possible concerns. Results Finally, 107 physicians responded to this survey: 66 (61.7%) had experience of performing FMT, and 86 (80.4%) replied that they were willing to perform FMT for CDI. Two-thirds of physicians (63.6%, n = 68) would perform FMT for recurrent CDI on patients who had at least three recurrences. The most common obstacle to performing FMT for the treatment of CDI was the lack of regulations or guidelines (55.1%, n = 59). Seventy-seven (72.0%) physicians would consider FMT for non-CDI diseases when conventional treatment had failed. The most common obstacle for FMT for the treatment of non-CDI diseases was low treatment efficacy (57.0%, n = 61). Conclusions Two-thirds of Korean physicians had experience of performing FMT, and many performed FMT for recurrent CDI. The results of this study will prove useful to researchers and practitioners in FMT in Korea.
12C/13C isotopic ratios in red-giant stars of the open cluster NGC 6791

Hungarian NKFI of the Hungarian National Research, Development and Innovation Office [K-119517]; Hungarian Academy of Sciences; Chilean BASAL Centro de Excelencia an Astrofisica Technologias Afines (CATA) [PFB-06/2007]; Fondecyt [1170518]; Ramon y Cajal fellowship [RYC-2013-14182]; Spanish Ministry of Economy and Competitiveness (MINECO) [AYA-2014-58082-P]; Alfred P. Sloan Foundation; U.S. Department of Energy Office of Science; Center for High-Performance Computing at the University of Utah; Brazilian Participation Group; Carnegie Institution for Science, Carnegie Mellon University; Chilean Participation Group; French Participation Group; Harvard-Smithsonian Center for Astrophysics; Instituto de Astrofisica de Canarias; Johns Hopkins University; Kavli Institute for the Physics and Mathematics of the Universe (IPMU) / University of Tokyo; Lawrence Berkeley National Laboratory; Leibniz Institut fur Astrophysik Potsdam (AIP); Max-Planck- Institut fur Astronomie (MPIA Heidelberg); Max-Planck- Institut fur Astrophysik (MPA Garching); Max-Planck-Institut fur Extraterrestrische Physik (MPE); National Astronomical Observatories of China; New Mexico State University; New York University; University of Notre Dame; Observatorio Nacional / MCTI; Ohio State University; Pennsylvania State University; Shanghai Astronomical Observatory; United Kingdom Participation Group; Universidad Nacional Autonoma de Mexico; University of Arizona; University of Colorado Boulder; University of Oxford; University of Portsmouth; University of Utah; University of Virginia; University of Washington; University of Wisconsin; Vanderbilt University; Yale University
The experience of female oncological patients and fertility preservation: A phenomenology study

Abstract Objective The aim of this study is to analyse the experience of fertility preservation among female oncological patients. Methods A phenomenological study was conducted in an Assisted Human Reproduction Unit. The sample was composed of 14 females of reproductive age diagnosed with a cancer that may affect reproductive function, who had undergone a fertility preservation procedure. In‐depth interviews were carried out, and the transcripts were entred into the Atlas.ti. v.8. 2.3 qualitative analysis software package. The steps proposed by Taylor–Bogdan were followed in the analysis of the data. Results Four thematic categories emerged in relation to the experience with the fertility preservation process: interruption of life plans and changes in the person; knowledge about fertility preservation options, reproductive capacity and impact because of the possible loss; dyadic relationshipsand social representations of fertility. Conclusions Patients suffer from difficulties when making decisions about fertility whilst dealing with a cancer diagnosis. They need adequate information and support from health professionals. Despite increasing awareness of fertility preservation, there is a lack of knowledge regarding patients' experiences and needs related to this process.
On the relative Contribution of high-redshift Galaxies and Active Galactic Nuclei to Reionization

In this paper we discuss the contribution of different astrophysical sources to the ionization of neutral hydrogen at different redshifts. We critically revise the arguments in favour of/against a substantial contribution of active galactic nuclei (AGNs) and/or Lyman break galaxies (LBGs) to the reionization of the Universe at z > 5. We consider extrapolations of the high-z quasi-stellar objects (QSO) and LBG luminosity functions (LFs) and their redshift evolution as well as indirect constraints on the space density of lower luminosity AGNs based on the galaxy stellar mass function. Since the hypothesis of reionization due to LBGs alone requires a significant contribution of faint dwarf galaxies and a LyC photon escape fraction (fesc) of the order of ∼20 per cent, in tension with present observational constraints, we examine under which hypothesis AGNs and LBGs may provide a combined relevant contribution to reionization. We show that a relatively steep faint end of the AGN LF, consistent with present constraints, provides a relevant (although sub-dominant) contribution, thus allowing us to recover the required ionizing photon rates with fesc ∼ 5 per cent up to z ∼ 7. At higher redshifts, we test the case for a luminosity-dependent fesc scenario and we conclude that, if the observed LBGs are indeed characterized by very low fesc, values of the order of fesc ∼ 70 per cent are needed for objects below our detection threshold, for this galaxy population to provide a substantial contribution to reionization. Clearly, the study of the properties of faint sources (both AGNs and LBGs) is crucial.
Plasmon mass scale in classical nonequilibrium gauge theory

Classical lattice Yang-Mills calculations provide a good way to understand different nonequilibrium phenomena in nonperturbatively overoccupied systems. Above the Debye scale the classical theory can be matched smoothly to kinetic theory. The aim of this work is to study the limits of this quasiparticle picture by determining the plasmon mass in classical real time Yang-Mills theory on a lattice in 3 spatial dimensions. We compare three methods to determine the plasmon mass: a hard thermal loop expression in terms of the particle distribution, an effective dispersion relation constructed from fields and their time derivatives, and by measuring oscillations between electric and magnetic field modes after artificially introducing a homogeneous color electric field. We find that a version of the dispersion relation that uses electric fields and their time derivatives agrees with the other methods within 50%.
A Meta-Analysis on the Impact of High BMI in Patients Undergoing Transcatheter Aortic Valve Replacement

Background: A paradoxical association of obesity with lower risk of transcatheter aortic valve replacement (TAVR) outcomes has been reported. We aimed to systematically review the literature and compare TAVR-related morbidity and mortality among individuals with overweight or obesity and their peers with normal body mass index (BMI). Methods: PubMed and Embase databases were systematically searched for studies reporting TAVR outcomes in different BMI groups. Separate meta-analyses were conducted for studies reporting hazard ratios (HR) and odds ratios/relative risks. Short- and mid-/long-term outcomes were examined. Results: 26 studies with a total of 74,163 patients were included in our study. Overweight was associated with lower risk of short-term mortality (HR: 0.77; 95% CI: 0.60–0.98) and mid-/long-term mortality (HR: 0.79; 95% CI: 0.70–0.89). Obesity was associated with lower risk for mid-/long-term mortality (HR: 0.79; 95% CI: 0.73–0.86), but no difference was observed in short-term mortality, although a trend was noted (HR: 0.87l 95% CI: 0.74–1.01). Individuals with obesity demonstrated an association with higher odds of major vascular complications (OR: 1.33; 95% CI: 1.05–1.68). Both overweight (OR: 1.16; 95% CI: 1.03–1.30) and obesity (OR: 1.26; 95% CI: 1.06–1.50) were associated with higher likelihood for receiving permanent pacemakers after TAVR. Conclusion: Individuals with overweight and obesity were associated with lower mortality risk compared to those with normal BMI but with higher likelihood of major vascular complications and permanent pacemaker implantation after TAVR.
Independent Homebirth Midwives in France: The Persecution of a Profession

ABSTRACT In France, although the vast majority of births take place in hospitals, some women prefer to give birth at home with the assistance of a midwife. In recent years, eight midwives attending home births have had their licenses revoked by the National Council of Midwives. In this article I discuss the complaints that led to seven midwives’ lifetime ban from practising, their reflections on why they were disbarred, and their perspectives on the technologization of childbirth. My goal is to understand why some independent midwives continue to attend home births without insurance, exposing themselves to disbarment and prosecution.
SPATIALLY RESOLVED [Fe ii] 1.64 μm EMISSION IN NGC 5135: CLUES FOR UNDERSTANDING THE ORIGIN OF THE HARD X-RAYS IN LUMINOUS INFRARED GALAXIES

Spatially resolved near-IR and X-ray imaging of the central region of the luminous infrared galaxy (LIRG) NGC 5135 is presented. The kinematical signatures of strong outflows are detected in the [Fe ii] 1.64 μm emission line in a compact region at 0.9 kpc from the nucleus. The derived mechanical energy release is consistent with a supernova rate of 0.05–0.1 yr−1. The apex of the outflowing gas spatially coincides with the strongest [Fe ii] emission peak and with the dominant component of the extranuclear hard X-ray emission. All these features provide evidence for a plausible direct physical link between supernova-driven outflows and the hard X-ray emitting gas in an LIRG. This result is consistent with model predictions of starbursts concentrated in small volumes and with high thermalization efficiencies. A single high-mass X-ray binary (HMXB) as the major source of the hard X-ray emission, although not favored, cannot be ruled out. Outside the active galactic nucleus, the hard X-ray emission in NGC 5135 appears to be dominated by the hot interstellar medium produced by supernova explosions in a compact star-forming region, and not by the emission due to HMXBs. If this scenario is common to (ultra)luminous infrared galaxies, the hard X-rays would only trace the most compact (⩽100 pc) regions with high supernova and star formation densities, therefore a lower limit to their integrated star formation. The star formation rate derived in NGC 5135 based on its hard X-ray luminosity is a factor of two and four lower than the values obtained from the 24 μm and soft X-ray luminosities, respectively.
Prevalence and predictors of benevolent childhood experiences among a representative sample of young people

Abstract Emerging research evidence suggests that benevolent childhood experiences (BCEs) may partly explain more favourable mental health outcomes among individuals affected by adverse childhood experiences (ACEs). However, much of this research has focused on adult populations. Consequently, this study sought to provide the first rigorous assessment of the prevalence and predictors of BCEs using a nationally representative sample of young people from Northern Ireland (NI). Participants were 11–19‐years‐olds (N = 1293) who participated in the NI Youth Wellbeing Prevalence Survey (NI‐YWS, 2020). Prevalence rates, gender differences and predictors of BCEs were investigated. Results revealed how most of the sample experienced multiple BCEs (95%, n = 1084), with females reporting higher levels of BCEs. Significant positive predictors of BCEs were female gender, parental education, living with both biological parents, and living in areas with lower deprivation, while significant negative predictors of BCEs included family being in receipt of social welfare and older age. Overall, this study highlights how BCEs are common, while the identification of factors associated with likelihood of having positive experiences during early development provides novel insights into those young people who may be at greater risk for maladaptive psychological outcomes.
X-ray spectroscopy of the z = 6.4 quasar SDSS J1148+5251

We present the 78-ks Chandra observations of the $z=6.4$ quasar SDSS J1148+5251. The source is clearly detected in the energy range 0.3-7 keV with 42 counts (with a significance $\gtrsim9\sigma$). The X-ray spectrum is best-fitted by a power-law with photon index $\Gamma=1.9$ absorbed by a gas column density of $\rm N_{\rm H}=2.0^{+2.0}_{-1.5}\times10^{23}\,\rm cm^{-2}$. We measure an intrinsic luminosity at 2-10 keV and 10-40 keV equal to $\sim 1.5\times 10^{45}~\rm erg~s^{-1}$, comparable with luminous local and intermediate-redshift quasar properties. Moreover, the X-ray to optical power-law slope value ($\alpha_{\rm OX}=-1.76\pm 0.14$) of J1148 is consistent with the one found in quasars with similar rest-frame 2500 \AA ~luminosity ($L_{\rm 2500}\sim 10^{32}~\rm erg~s^{-1}$\AA$^{-1}$). Then we use Chandra data to test a physically motivated model that computes the intrinsic X-ray flux emitted by a quasar starting from the properties of the powering black hole and assuming that X-ray emission is attenuated by intervening, metal-rich ($Z\geq \rm Z_{\odot}$) molecular clouds distributed on $\sim$kpc scales in the host galaxy. Our analysis favors a black hole mass $M_{\rm BH} \sim 3\times 10^9 \rm M_\odot$ and a molecular hydrogen mass $M_{\rm H_2}\sim 2\times 10^{10} \rm M_\odot$, in good agreement with estimates obtained from previous studies. We finally discuss strengths and limits of our analysis.