Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Ambulatory Care Sensitive Conditions to Assess Primary Health Care Performance during Disasters: A Systematic Review

Introduction: Ambulatory care sensitive conditions (ACSCs) are health conditions for which appropriate primary care intervention could prevent hospital admission. ACSC hospitalization rates are a well established parameter for assessing the performance of primary health care (PHC). Although this indicator has been extensively used to monitor the performance of PHC systems in peacetime, its consideration during disasters has been neglected. The World Health Organization (WHO) has acknowledged the importance of PHC in guaranteeing continuity of care during and after a disaster for avoiding negative health outcomes. Method: A systematic review was conducted to evaluate the extent and nature of research activity on the use of ACSCs during disasters, with an eye toward finding innovative ways to assess the level of PHC function at times of crisis. Online databases were searched to identify papers. Results: A final list of nine publications was retrieved. The analysis of the reviewed articles confirmed that ACSCs can serve as a useful indicator of PHC performance during disasters, with several caveats that must be considered. Conclusion: The reviewed articles cover several disaster scenarios and a wide variety of methodologies showing the connection between ACSCs and health system performance. The strengths and weaknesses of using different methodologies are explored and recommendations are given for using ACSCs to assess PHC performance during disasters.
Autoestima y recuperación para la reinserción social en mujeres del Centro de Rehabilitación Social de Portoviejo

La autoestima está relacionada con los procesos psicosociales. El contexto carcelario genera tensión y efectos psicológicos que deterioran la autopercepción y la autoestima del individuo. Este estudio buscó determinar la influencia de la autoestima y la recuperación en la reinserción social de las mujeres privadas de libertad del Centro de Rehabilitación Social de Portoviejo. La metodología utilizada fue descriptiva, con enfoque cualitativo apoyado en el paradigma cuantitativo. Se trabajó con el método cuasiexperimental. La Escala de Autoestima de Rosenberg se utilizó para establecer los niveles de autoestima en 100 mujeres privadas de libertad. Los resultados denotaron un índice de baja autoestima de las internas. La entrevista con los responsables del área de tratamiento confirmó la intervención limitada en el procedimiento para fortalecer la autopercepción. Según los resultados obtenidos, se concluyó que este centro de rehabilitación social requiere la aplicación de un protocolo más efectivo que garantice la restauración y protección de la salud mental de las reclusas.
Linear Optimization and Extensions: Theory and Algorithms

A solution to get the problem off, have you found it? Really? What kind of solution do you resolve the problem? From what sources? Well, there are so many questions that we utter every day. No matter how you will get the solution, it will mean better. You can take the reference from some books. And the linear optimization and extensions theory and algorithms is one book that we really recommend you to read, to get more solutions in solving this problem.
Oral Health-related Quality of Life (OHRQoL) Following Surgical Extraction of Impacted Mandibular Third Molars: Preliminary Observations in a Saudi Arabian Subpopulation

Introduction: OHQoL is crucial for the best preoperative assessment and development of suitable indications for mandibular third molar surgical extraction. The current study hopes to report QoL after surgical extraction of impacted mandibular third molars. Materials and Methods: This was a prospective study conducted in the Department of Oral and Maxillofacial Surgery, between January 2020 and April 2020. After consenting to partake in the study, patients’ baseline demographics, indication for seeking third molar removal and laterality of impaction were recorded. All the surgical extractions were performed by the same surgeon. Pain was assessed pre and postoperatively with the numerical pain rating scale while QoL was assessed pre and postoperatively using the validated Arabic version of the 16 item United Kingdom Oral Health Related Quality of Life measure (UK-OHQoL). Results: A total of 92 patients were recruited. There are 41 (44.6%) males and 51 (55.4%) females with M:F of 1:1.2. Age range was between 18 and 48 years with a mean of (31.2 ± 6.6) years. Age group 20–29 years constitutes the highest number of patients. Subscales: eating, appearance, sleep, mood and work revealed more percentage complaints (42.9%, 23.4%, 24.7%, 28.6%, and 16.9%, respectively). Regarding mean domain and overall QoL scores, it was observed that there was gradual improvement in mean scores from the Pre-op values and the review periods with best mean QoL reported at POD 14Conclusion: Improvement in overall mean QoL scores during the review periods as compared with the preoperative score was observed. Eating, appearance, sleep, mood and work subscales revealed more percentage complaints.
Comprehensive Expression Profiling and Molecular Basis of CDC28 Protein Kinase Regulatory Subunit 2 in Cervical Cancer

More and more evidence suggests the oncogenic function of overexpressed CDC28 protein kinase regulatory subunit 2 (CKS2) in various human cancers. However, CKS2 has rarely been studied in cervical cancer. Herein, taking advantage of massive genetics data from multicenter RNA-seq and microarrays, we were the first group to perform tissue microarrays for CKS2 in cervical cancer. We were also the first to evaluate the clinical significance of CKS2 with large samples (980 cervical cancer cases and 422 noncancer cases). We further excavated the mechanism of the tumor-promoting activities of CKS2 in cervical cancer through analysis of genetic mutation profiles, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) significant enrichment of genes coexpressed with CKS2. According to the results, expression data from multilevels unanimously supported the overexpression of CKS2 in cervical cancer. Patients with cervical cancer in stage II from inhouse microarrays had significantly higher expression of CKS2, and CKS2 overexpression had an adverse impact on the disease-free survival status of cervical cancer patients in GSE44001. Both mutation types of mRNA high and mRNA low appeared in cervical cancer cases from the TCGA Firehose project. Gene coexpressed with CKS2 participated in pathways including the cell cycle, estrogen signaling pathway, and DNA replication. In summary, upregulated CKS2 is closely associated with the malignant clinical development of cervical cancer and might serve as a valuable therapeutic target in cervical cancer.
Auxiliary functions for optimal price setting

IMF Working Papers describe research in progress by the author(s) and are published to elicit comments and to encourage debate. The views expressed in IMF Working Papers are those of the author(s) and do not necessarily represent the views of the IMF, its Executive Board, or IMF management. Abstract We study the macroeconomic effects of the COVID-19 epidemic in a quantitative dynamic general equilibrium setup with nominal rigidities. We evaluate various containment policies and show that they allow to dramatically reduce the welfare cost of the disease. Then we investigate the role that monetary policy, in its capacity to manage aggregate demand, should play during the epidemic. According to our results, treating the observed output contraction as a standard recession leads to overly expansionary policy. Finally, we check how central banks should resolve the trade-off between stabilizing the economy and containing the epidemic. If no administrative restrictions are in place, the second motive prevails and, despite the deep recession, optimal monetary policy is in fact contractionary. Conversely, if sufficient containment measures are introduced, central bank interventions should be expansionary and help stabilize economic activity.
ON HYPERSURFACES IN A HOMOGENEOUS RIEMANNIAN MANIFOLD

$r$ where $k$ denotes the curvature (defined up to a sign) of $c$ . We want to extend this proposition to immersed hypersurfaces which are contained in a domain with regular smooth boundary in a Riemannian manifold in terms of mean curvature. In this paper we investigate the problem stated above in the case where ambieant spaces are homogeneous Riemannian manifolds. Theorem 1.1 is the main theorem of this paper which is an extension of the proposition stated above. In order to prove Theorem 1.1 we need to study a quasilinear elliptic partial differential equation of second order. It will be carried out in Section 2. We think that the results obtained there is useful for studies of hypersurfaces in a Riemannian manifold. The complete $pr\ovalbox{\tt\small REJECT} f$ of Theorem 1.1 will be given in tection 4. In the latter half of Section 4 we study some properties of minimal hypersurfaces in a homogeneous Riemannian manifold. In the last section we generalize the results obtained in [6].
Contact Processes on Random Regular Graphs

We show that the contact process on a random $d$-regular graph initiated by a single infected vertex obeys the "cutoff phenomenon" in its supercritical phase. In particular, we prove that when the infection rate is larger than the critical value of the contact process on the infinite $d$-regular tree there are positive constants $C, p$ depending on the infection rate such that for sufficiently small $\epsilon> 0$, when the number $n$ of vertices is large then (a) at times $t< (C - \epsilon) \log n$ the fraction of infected vertices is vanishingly small, but (b) at time $(C + \epsilon) \log n$ the fraction of infected vertices is within $\epsilon$ of $p$, with probability $p$.
Prediction model of atmospheric refractive index structure parameter in coastal area

In this paper, we focus on the prediction of atmospheric refractive index structure parameter () in coastal area using the routine meteorological parameters. Based on the micrometeorology, macrometeorology and Monin–Obukhov similarity theory, three modified prediction models of are presented in combination with the long-term observation data of and meteorological parameters in coastal city, respectively. For different weather, the applicable cases of three prediction models are comparatively analysed and their applicable effects are comprehensively evaluated. The results indicate that the modified micrometeorology model of shows better applicability for overcast sky, the offshore macrometeorology model of displays better predictability for sunny day and the offshore Thiermann model provides better availability for overcast sky, cloudy day, overcast to sunny or sunny to overcast day.
Spectroscopic Study of Four Metal-poor Carbon Stars from the Hamburg/ESO Survey: On Confirming the Low-mass Nature of Their Companions

Elemental abundances of extrinsic carbon stars provide insight into the poorly understood origin and evolution of elements in the early Galaxy. In this work, we present the results of a detailed spectroscopic analysis of four potential carbon star candidates from the Hamburg/ESO Survey (HES): HE 0457−1805, HE 0920−0506, HE 1241−0337, and HE 1327−2116. This analysis is based on the high-resolution spectra obtained with Mercator/HERMES (R ∼ 86,000) and SUBARU/HDS (R ∼ 50,000). Although the abundances of a few elements, such as Fe, C, and O, are available from medium-resolution spectra, we present the first ever detailed high-resolution spectroscopic analysis for these objects. The objects HE 0457−1805 and HE 1241−0337 are found to be CEMP-s stars, HE 0920−0506 a CH star, and HE 1327−2116 a CEMP-r/s star. The object HE 0457−1805 is a confirmed binary, whereas the binary status of the other objects is unknown. The locations of program stars on the diagram of absolute carbon abundance A(C) versus [Fe/H] point at their binary nature. We have examined various elemental abundance ratios of the program stars and confirmed the low-mass nature of their former AGB companions. We have shown that the i-process models could successfully reproduce the observed abundance pattern in HE 1327−2116. The analysis performed for HE 0457−1805, HE 0920−0506, and HE 1241−0337 based on the FRUITY parametric models confirmed that the surface chemical compositions of these three objects are influenced by pollution from low-mass AGB companions.
Concept Maps in Immunology: A Metacognitive Tool to Promote Collaborative and Meaningful Learning among Undergraduate Medical Students

Introduction: Concept maps are graphical representations of knowledge that connect concepts, ideas, and relationships. The present study aims at assessing the perception of medical students in utilization of concept maps as a tool to foster their lifelong learning skills in immunology. Methods: The current study was approved by Institutional Ethics and Review Committee. Third-year undergraduate (MD3) medical students of the academic year 2021-22 were sensitized about the concept map study and included after obtaining their informed consent. The students worked in teams to find answers and link the different words or phrases of the concept maps. At the end of the immunology course, students’ perception on concept map-based learning strategy was assessed. A pre-designed, self-administered questionnaire, pre-validated by subject experts for relevance and feasibility, was used for the study. The questionnaire included some quantitative questions assessed by using 3-point Likert Scale and an open-ended question to receive students’ comments on concept map-based learning strategy. The responses were collected and analyzed using SPSS version 22. Descriptive statistics was used for the quantitative variables, tabulated as numbers and percentages while the qualitative data was analyzed by thematic analysis. The quantitative data results were prioritized but supported by students’ comments on open ended question. Results: Out of 133 eligible participants, 109 students who volunteered and completed the study were included. Majority of our participants (>80%) welcomed the concept map-based learning strategy. Almost 4 out of 5 expressed that concept maps are interesting and enjoyable, encourage active participation, peer discussion, and enhance critical thinking and problem-solving skills. More than 80% of the students agreed that concept maps promoted deep understanding of the topic and lifelong learning. Nearly 3 out of 4 students suggested including concept maps in many immunology topics in future. Majority of students penned down positive comments indicating concept map tool facilitates metacognitive skills. Conclusion: From the study, it can be concluded that concept maps are effective active learning strategies to improve the metacognitive domain of medical students in immunology course, thus assisting them to become better lifelong learners.
The Einstein Observatory Catalog of IPC X-ray Sources

The Einstein Observatory (HEAO-2, launched November 13, 1978) achieved radically improved sensitivity over previous x-ray missions through the use of focusing optics, which simultaneously afforded greatly reduced background and produced true images. During its 2.5-yr mission, the Einstein X-Ray Telescope was pointed toward some 5,000 celestial targets, most of which were detected, and discovered several thousand additional 'serendipitous' sources in the observed fields. This catalog contains contour diagrams and source data, obtained with the imaging proportional counter in the 0.16 to 3.5 keV energy band, and describes methods for recovering upper limits for any sky position within the observed images. The main catalog consists of six volumes (numbered 2 through 7) of right ascension ordered pages, each containing data for one observation. Along with the primary documentation describing how the catalog was constructed, volume 1 contains a complete source list, results for merged fields, a reference system to published papers, and data useful for calculating upper limits and fluxes.
Analysis of Common Beta-Thalassemia (β-Thalassemia) Mutations in East Java, Indonesia

Background The frequency of the beta-thalassemia (β-thalassemia) gene in Indonesia ranges from 3 to 10%. However, in the East Java province, there is still limited information on the prevalence of β-thalassemia mutations in clinically diagnosed beta-thalassemia patients of East Java. Therefore, this study aimed to characterize β-thalassemia mutations in selected patients in the East Java province of Indonesia. Methods This is an analytical observational study. Diagnosis of β-thalassemia was based on clinical presentation, complete blood count (CBC), and hemoglobin (Hb) electrophoresis. Blood specimens taken from each patient in three ethylenediaminetetraacetic acid (EDTA) tubes were analyzed for CBC and Hb electrophoresis and processed for DNA extraction and subsequent polymerase chain reaction (PCR). Detection of mutations in Hemoglobin Subunit Beta (HBB) gene exons 1–3 of the β-thalassemia gene as the common mutation in Indonesia was done using PCR followed by Sanger sequencing. Results In total, 33 (n = 33) participants were involved in this study with ages ranging from 5 to 17 years comprising 19 women and 14 men. Their ethnic origins were Javanese (n = 30) and Chinese (n = 3). CBC results showed that mean ± standard deviation (SD) for Hb, red blood cell (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW)-CV were 81.2 ± 7.0 g/L; 3.40 ± 0.39 × 109/L; 71.05 ± 5.72 fL; 24.12 ± 2.45 pg; 33.91 ± 1.47 g/dl; 24.38 ± 6.02%, respectively. Hb electrophoresis revealed that 5 out of 33 participants had beta-thalassemia and 28 out of 33 participants had hemoglobinopathy (Hb) E/beta-thalassemia. Results of Sanger sequencing showed the following genotype variations in the samples: 12 (36.4%) with βCD26/βIVS−I−5; 6 (18.2%) with βCD26/βCD35; 3 (9.1%) with βCD26/βIVS−I−2; 2 (6.1%) with βCD27/28/βCD40; 2 (6.1%) with βIVS−I−1/βCAP+1; and βCD26/βIVS−I−1; βIVS−I−5/βCAP+1; βIVS−I−5/βCD35; βCD26/βCD37; βCD26/βCD15; βCD26/βCD40; and βIVS−I−5/βCD19 in 1 (3%) sample, respectively, and 1 (3%) had no abnormality detected in sequencing even though electrophoresis showed abnormality in the migration pattern. The βCD26/βIVS−I−5 mutation was found in samples that were noted to have Hb E/beta-thalassemia on Hb electrophoresis. Conclusion The underlying genetic variations are heterogeneous in thalassemia patients in East Java, where 12 variants were found. The most common variant was βCD26/βIVS−I−5, which all accounted for Hb E/beta-thalassemia on Hb electrophoresis. Furthermore, 28 out of 33 participants had hemoglobinopathy (Hb) E/beta-thalassemia.
Vibrational couplings between protein and cofactor in bacterial phytochrome Agp1 revealed by 2D-IR spectroscopy

Significance Two-dimensional infrared absorption (2D-IR) spectroscopy is severely limited in its application to larger proteins due to broad and overlapping signals in the amide I region. Here, we overcome this limitation and isolate couplings between pairwise two single-molecular groups in the biotechnologically relevant phytochrome Agp1 (510 aa) by calculating light-induced difference spectra. In phytochromes, the photoactivation of a cofactor with a relatively small structural change triggers a large-scale refolding of big parts of the protein, but the mechanism of that interaction is not understood. We observe cross-peaks in the 2D-IR spectra that are directly related to the changing dipole coupling between the cofactor and the part of the protein that refolds, suggesting that both sites stabilize each other mutually.
Exploring psychopathological and cognitive factors associated with help-seeking intentions among Korean high school students: A cross-sectional study

Competitive college admissions and academic pressure have continuously increased the psychopathological burden of Korean high school students. Seeking help is one of the primary means of managing mental health, and more attention is required. This study aimed to explore the psychopathological and cognitive factors related to the help-seeking intentions of Korean high school students. This cross-sectional study was conducted between July and August 2020 using the General Help-Seeking Questionnaire, Symptom Checklist-90-R, and Mental Health Literacy Scale. Four hundred and twenty-one Korean high school students (275 males, 146 females; average age 17.44 years [standard deviation = 0.651]) completed self-report questionnaires. We performed analysis of variance, Spearman’s correlation analysis, and stepwise regression analysis to explore the factors related to help-seeking intentions. The final model showed an explanatory power of 23.6% for the overall variance in help-seeking intentions. Somatization (β = −0.200; P = .001) and hostility (β = −0.203; P = .001) had a negative effect on help-seeking intentions. Further, knowledge of where to seek information (β = 0.230; P < .001) and attitudes promoting recognition and help-seeking behavior (β = 0.095; P = .030) had a positive effect. Students responded to society’s negative awareness of mental illness by converting psychopathology into socially acceptable symptoms. Educational support can improve mental health literacy. This study is expected to help improve mental illness awareness and increase adolescents’ access to public services.
Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients

We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/inflammatory and nutritional conditions were used as variables. Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1–2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/dL by Fisher’s exact test. These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL.