Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Trimethylamine N-Oxide with Normal Aging and Neurocognitive Disorders: A Narrative Review

Aging-related neurocognitive disorder (NCD) is a growing health concern. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived metabolite from dietary precursors, might emerge as a promising biomarker of cognitive dysfunction within the context of brain aging and NCD. TMAO may increase among older adults, Alzheimer’s disease patients, and individuals with cognitive sequelae of stroke. Higher circulating TMAO would make them more vulnerable to age- and NCD-related cognitive decline, via mechanisms such as promoting neuroinflammation and oxidative stress, and reducing synaptic plasticity and function. However, these observations are contrary to the cognitive benefit reported for TMAO through its positive effects on blood–brain barrier integrity, as well as from the supplementation of TMAO precursors. Hence, current disputable evidence does not allow definite conclusions as to whether TMAO could serve as a critical target for cognitive health. This article provides a comprehensive overview of TMAO documented thus far on cognitive change due to aging and NCD.
What Is Different in Acute Hematologic Malignancy-Associated ARDS? An Overview of the Literature

Background and Objectives: Acute hematologic malignancies are a group of heterogeneous blood diseases with a high mortality rate, mostly due to acute respiratory failure (ARF). Acute respiratory distress syndrome (ARDS) is one form of ARF which represents a challenging clinical condition. The paper aims to review current knowledge regarding the variable pathogenic mechanisms, as well as therapeutic options for ARDS in acute hematologic malignancy patients. Data collection: We provide an overview of ARDS in patients with acute hematologic malignancy, from an etiologic perspective. We searched databases such as PubMed or Google Scholar, including articles published until June 2022, using the following keywords: ARDS in hematologic malignancy, pneumonia in hematologic malignancy, drug-induced ARDS, leukostasis, pulmonary leukemic infiltration, pulmonary lysis syndrome, engraftment syndrome, diffuse alveolar hemorrhage, TRALI in hematologic malignancy, hematopoietic stem cell transplant ARDS, radiation pneumonitis. We included relevant research articles, case reports, and reviews published in the last 18 years. Results: The main causes of ARDS in acute hematologic malignancy are: pneumonia-associated ARDS, leukostasis, leukemic infiltration of the lung, pulmonary lysis syndrome, drug-induced ARDS, radiotherapy-induced ARDS, diffuse alveolar hemorrhage, peri-engraftment respiratory distress syndrome, hematopoietic stem cell transplantation-related ARDS, transfusion-related acute lung injury. Conclusions: The short-term prognosis of ARDS in acute hematologic malignancy relies on prompt diagnosis and treatment. Due to its etiological heterogeneity, precision-based strategies should be used to improve overall survival. Future studies should focus on identifying the relevance of such etiologic-based diagnostic strategies in ARDS secondary to acute hematologic malignancy.
CBD Supplementation Has a Positive Effect on the Activity of the Proteolytic System and Biochemical Markers of Honey Bees (Apis mellifera) in the Apiary

Simple Summary The purpose of our study was to determine how CBD extract influences resistance in the hemolymph (insect blood) of honey bees in the hive test. The bees were divided into 3 groups: (CSy) bees fed with CBD in sugar syrup; (CSt) cotton strip with CBD placed in hive, (C) control bees fed sugar syrup. To determine the state of immunity, we used the analysis of the activity of the proteolytic system and biochemical markers, such as “liver tests”, and the concentration of selected ions and key compounds for the functioning of the organism. CBD extract increased the total protein concentration, proteases and their inhibitor activities in each age (except for acidic protease activities in the 21st and 28th day and alkaline protease inhibitor activities in the 28th day in the CSt group), increased concentrations of markers: ALP, AST, ALT; and glucose; triglycerides; cholesterol and creatinine. A decrease in concentration in experimental groups was noticed for urea acid and albumin compared to group C. Higher activities/concentrations of most of parameters were obtained in the CSy compared to the CSt and C. The CBD supplementation can positively influence bees’ resistance. Abstract We examined how CBD extract influences the activity of the immune system in the hemolymph of honey bees in the hive test. The bees were divided into 3 groups: (CSy) bees fed with CBD in sugar syrup with glycerin; (CSt) cotton strip with CBD placed in hive bees fed pure sugar syrup, (C) control bees fed sugar syrup with glycerin. CBD extract increased the total protein concentrations, proteases and their inhibitor activities in each age (the except for acidic protease activities in the 21st and 28th day and alkaline protease inhibitor activities in the 28th day in CSt group) in comparison with group C. In the groups with the extract there was also an increase in the enzymatic marker activities: ALP, AST (decrease on day 28 for CSt), ALT; and non-enzymatic marker concentrations: glucose; triglycerides; cholesterol and creatinine. The urea acid and albumin concentrations were lower in CSy and CSt groups compared to the C group (higher concentration of albumin was displayed by control bees). Higher activities/concentrations of most of biochemical parameters were obtained in the CSy compared to the CSt and C. CBD supplementation can positively influence workers’ immune system.
Holographic operator mixing: The Hall experiment

We calculate the Ohmic and Hall conductivities from linear response theory in a system consisting of the intersection of Nc Dp-branes and Nf << N_c Dq-branes. Agreement is found between previous results found in a macroscopic approach comparing induced currents with external electric fields. The issue of how to deal with mixed operators is raised. The retarded Green's function is given by a matrix that can be computed from the boundary action similarly to the Green's function for uncoupled operators.
G-Theory of \F_1-Algebras I: the Equivariant Nishida Problem

We develop a version of G-theory for \F_1-algebras and establish its first properties. We construct a Cartan assembly map to compare the Chu-Morava K-theory for finite pointed groups with our G-theory. We compute the G-theory groups for finite pointed groups in terms of stable homotopy of some classifying spaces. We also construct combinatorial Grayson operations on them. We discuss how our formalism is relevant to the Equivariant Nishida Problem - it asks whether there are operations on \S^G that endow \oplus_n\pi_{2n}(\S^G) with a pre-\lambda-ring structure, where G is a finite group and \S^G is the G-fixed point spectrum of the equivariant sphere spectrum.
Effectiveness of a Training Program in School Teachers on the Role of Sugars in Oral and General Health

Background: Schools have a powerful influence on children's development and well-being, and school teachers are considered role models to transmit life values and instill health-related behaviors. The effectiveness of a training program for school teachers in understanding the role of sugars and their impact on oral and overall health has not been previously reported. Aim: The present study aimed to assess the effectiveness of a training program for school teachers on the role of sugars in oral and general health. Methods: An interventional study was carried out on 308 Kendriya Vidyalaya Sangathan school teachers to evaluate the effectiveness of a training program in improving school teachers' knowledge of the role of sugars in oral and overall health. The training program was carried out using a training module, and a validated questionnaire was utilized to assess school teachers' knowledge before and after the training program. Results: The overall evaluation of mean knowledge change scores revealed significantly higher scores after the training program (8.12 ±1.58) when compared with the pre-training scores (6.84±1.66) Conclusion: A training program on the role of sugars in oral and general health effectively improved school teachers' knowledge.
Analisis Adaptasi Pelaksanaan MBKM dalam Kurikulum Perguruan Tinggi Akademik di STKIP Taman Siswa Bima (Telaah Studi pada Prodi PGSD, PJKR dan Pendidikan Matematika; Hibah Program Bantuan Prodi Menerapkan Kerja Sama Kurikulum MBKM)

Tujuan Penelitian ini yaitu (1) Mendeskripsikan seluruh rangkaian proses pelaksanaan kurikulum MBKM di prodi Matematika, PGSD, dan PJKR; (2) Mengidentifikasi dan mengevaluasi hasil capaian Kurikulum MBKM di prodi matematika PGSD dan PJKR; (3) Menelaah dan merumuskan solusi Hambatan Pelaksanaan MBKM di STKIP Taman Siswa Bima. Metode Penelitian ini adalah kualitatif yang menghasilkan data berupa deskripsi uraian informasi yang bersifat mendalam dan sistematis. Sedangkan teknik pengumpulan data dengan wawancara, Observasi dan Dokumentasi. Sedangkan teknik analisis data yaitu reduksi, penafsiran dan penarikan kesimpulan. Berdasarkan hasil penelitian yang dilakukan, yaitu; (1) Proses pelaksanaan MBKM di Prodi Pendidikan Matematika, PJKR dan PGSD, mengikuti indikator kerja utama (IKU) sesuai dengan pedoman dan regulasi yang ditetapkan oleh Kemendikbud, dengan mengintegrasikan tiga indikator kerja MBKM, yaitu; Magang/Praktek, kewirausahaan dan Pertukaran Pelajar/Mahasiswa; (2) Hasil capaian pengintegrasian MBKM dalam kurikulum Prodi Pendidikan Matematika, yaitu; buku pedoman Kurikulum MBKM dan mahasiswa perwakilan dari prodi pendidikan matematika, melakukan magang/praktek kerja di BPS Kabupaten Bima, mengajar di sekolah melaui PPL 1 sebahagian lagi terlibat dalam pertukaran pelajar dengan Prodi Matematika kampus IKIP Bojo Negoro Jatim, dan mahasiswa juga terlibat dalam kegiatan wirausaha dibawah pengawasan prodi.
Influence of sodium para nitrophenolate 0.3% SL on growth and yield of rice in new Alluvial Zone (NAZ) of West Bengal

Plants produce their own plant growth regulators (PGRs); however various studies have shown that plants may respond to exogenously applied growth hormones. Field experiments were conducted in rabi and kharif seasons of 2017-18 & 2018-19 at Kalyani D block Farm, Kalyani, Nadia under Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, West Bengal with total six (6) treatments; T 1 : Sodium para-nitrophenolate 0.3% SL @5 ml L -1 , T 2 : Sodium para-nitrophenolate 0.3% SL @10 ml L -1 , T 3 : Sodium para-nitrophenolate 0.3% SL @20 ml L -1 , T 4 : Triacontanol 0.1% EW @250 ml ha -1 , T 5 : Gibberellic acid 0.001%L @180 ml ha -1 and T 6 : Untreated control; to evaluate the bio-efficacy of Sodium para-nitrophenolate 0.3% SL (PGR) on boro and kharif rice at New Alluvial Zone (NAZ) of West Bengal. All the plant growth regulators (PGRs) were applied as foliar spray at three times in both the seasons i.e. 1 st spray at 20-25 DAT, 2 nd spray at 45-50 DAT and 3 rd spray at 65-70 DAT. Results from the experiment revealed that the application of Sodium para-nitrophenolate 0.3% SL @2% a.i., i.e., 20 ml L -1 formulation significantly increased the growth attributes i.e. height of hill (cm) and number of effective tillers per sq.m. , yield attributes i.e. length of panicle (cm), number of filled grains per panicle and 1000 seed wt. (g) and ultimately grain yield and straw yield (t ha -1 ) of both boro and kharif rice in both the year while effect on days to maturity and days to 50% flowering of crop remain same instead of application of plant growth regulators.
Changes in industry marketing payments to physicians during the covid-19 pandemic: quasi experimental, difference-in-difference study

Objective To determine changes in industry marketing payments to physicians due to the covid-19 pandemic. Design Quasi experimental, difference-in-difference study. Data source US nationwide database of licensed physicians, the National Plan and Provider Enumeration System, which was linked to a database of industry marketing payments made to physicians, Open Payments. Population All licensed US physicians from 2018 to 2020 and those who received payments from industry. Main outcome measures Changes in the value and the number of monthly industry payments physician received before (January-February 2020) and during the pandemic (April-December 2020) were assessed, adjusting for physicians’ characteristics (gender and specialty). As the control, data for the same months in 2019 were used. Industry payments by type of payments (eg, meals, travel, consulting fees, speaker compensation, honorariums), were also examined. Results Among 880 589 US physicians included in this study, 267 463 (30.4%) physicians received a total of 4 117 482 non-research payments with $626 million ($710 per physician; £610; €708) in 2020 (40-44% decrease from $1047m in 2018 and $1115m in 2019). Industry payments decreased significantly in the months of the covid-19 pandemic (adjusted change in the value of −48.4%; 95% confidence interval −50.6 to −46.2; P<0.001; and adjusted change in the number of −47.4%, 95% confidence interval −47.7 to −47.1; P<0.001), particularly for meals and travel fees. No evidence was seen of a decrease in the number of industry payments for consulting and honorariums. A similar pattern was observed across physicians’ gender and specialty. Conclusions Industry payments to physicians, particularly those involving physical interactions such as meals and travel, substantially decreased during the pandemic. How such changes affect prescription practices and the quality of clinical practice in the long term should be investigated.
Acquired Von Willebrand Deficiency in Adults With Aortic Stenosis: A Systematic Review

Von Willebrand factor (VWF) deficiency is associated with bleeding complications. The congenital type of Von Willebrand disease(VWD) is a very well-known bleeding disorder and sometimes may be associated with life-threatening hemorrhage. This systematic review is aimed at gathering further knowledge regarding the pathology of an acquired VWD form within a population of patients with aortic stenosis (AS) by shortlisting quality articles on this theme, through the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) 2020 guidelines. High shear stress caused by the stenotic valve cleaves VWF multimers, causing a relative state of deficiency. The condition returns to baseline immediately following surgical replacement of the valve. Results across eight studies reviewed by a majority concluded that in an AS patient with bleeding, the most likely cause is an acquired deficiency of VWF, associated with factors influencing blood flow and caused by the in-situ valve. However, several studies suggested otherwise/were misclassifications. This review highlighted the relationship between AS and acquired VWF deficiency and should be foreseen as an adverse complication, attracting further research and future theragnostic strategies for this condition.
Effects of Substitution Ratios of Zinc-Substituted Hydroxyapatite on Adsorption and Desorption Behaviors of Bone Morphogenetic Protein-2

Understanding interactions between bone morphogenetic proteins (BMPs) and biomaterials is of great significance in preserving the structure and bioactivity of BMPs when utilized in clinical applications. Currently, bone morphogenetic protein-2 (BMP-2) is one of the most important growth factors in bone tissue engineering; however, atomistic interactions between BMP-2 and zinc-substituted hydroxyapatite (Zn-HAP, commonly used in artificial bone implants) have not been well clarified until now. Thus, in this work, the interaction energies, binding/debinding states, and molecular structures of BMP-2 upon a series of Zn-HAP surfaces (Zn-HAPs, 1 at%, 2.5 at%, 5 at%, and 10 at% substitution) were investigated by hybrid molecular dynamics (MD) and steered molecular dynamics (SMD) simulations. Meanwhile, cellular studies including alkaline phosphatase (ALP) activity and reverse transcription-polymerase chain reaction (RT-PCR) assay were performed to verify the theoretical modeling findings. It was found that, compared to pure HAP, Zn-HAPs exhibited a higher binding affinity of BMP-2 at the adsorption process; meanwhile, the detachment of BMP-2 upon Zn-HAPs was more difficult at the desorption process. In addition, molecular structures of BMP-2 could be well stabilized upon Zn-HAPs, especially for Zn10-HAP (with a 10 at% substitution), which showed both the higher stability of cystine-knots and less change in the secondary structures of BMP-2 than those upon HAP. Cellular studies confirmed that higher ALP activity and osteogenic marker gene expression were achieved upon BMP-2/Zn-HAPs than those upon BMP-2/HAP. These findings verified that Zn-HAPs favor the adsorption of BMP-2 and leverage the bioactivity of BMP-2. Together, this work clarified the interaction mechanisms between BMP-2 and Zn-HAPs at the atom level, which could provide new molecular-level insights into the design of BMP-2-loaded biomaterials for bone tissue engineering.
Investigation of Nutritional Level Habits in Sedentary Women According to Body Mass Index

In this study, it was aimed to examine the nutritional level habits of sedentary women according to body mass index. A total of 504 sedentary women with a mean age of 48.79±3.65 living in Gaziantep city center voluntarily participated in the study. In order to determine the nutritional habits of the subjects participating in the study, a three-factor eating habits questionnaire, which was adapted into Turkish in 2015 by Kıvanç et al., was applied. The "IBM SPSS Statistics 22" package program was used in the statistical analysis of the obtained data, and the normality analysis of the data was tested with the Kolmogorov Smirnov test. One-way anavo test was used to compare normally distributed data. In this study, the margin of error was taken as 0.05. As a result of the analysis; It was determined that sedentary women with a high body mass index did not avoid eating at any time of the day, and they needed to eat when they felt restless and lonely. It was also found that these women ate until they finished the food in front of them even when they were full, they saw eating as a philosophy of life and they were not very conscious about nutrition. As a result; The reason for the nutritional irregularities of sedentary women is mostly due to insufficient nutritional knowledge. We believe that it will be possible to correct sedentary women's malnutrition behaviors and gain healthy and correct eating habits through nutrition education.
Protein Hydrolysates from Animal or Vegetal Sources Affect Morpho-Physiological Traits, Ornamental Quality, Mineral Composition, and Shelf-Life of Chrysanthemum in a Distinctive Manner

Protein hydrolysates (PHs) are a prominent category of plant biostimulants, mainly constituted of amino acids, oligopeptides and polypeptides, obtained by partial hydrolysis of animal or plant protein sources. Despite scientific evidence supporting the biostimulant action of PHs on vegetables, the morphological, physiological, and shelf-life performances underlying the PH action on cut flowers are still poorly explored. Accordingly, the aim of this research is to assess the effects of three commercial biostimulants, one animal PH (PH A, Hicure®) and two plant PHs (PH V1, Trainer® and PH V2, Vegamin©), on two chrysanthemum (Chrysanthemum morifolium) cultivars (Pinacolada and Radost). In both cultivars, only the plant-derived PH (V1 and V2) treatments recorded significantly higher fresh plant biomass than the control (on average +18%, in both cultivars). The foliar application of the vegetal-derived PHs but not the animal one, particularly in Pinacolada, improved the status of plants, stimulating stem elongation and the apical flower diameter. In Pinacolada, applications with PH V1 resulted in a significant increase in nitrate and P concentration in leaves and Ca content in flowers compared with the control (+43%, +27%, and +28% for nitrate, P, and Ca, respectively). In Radost, PH A and PH V2 applications caused a significant reduction in nitrate concentration in both leaves and flowers compared with the control. One week after harvest, in both cultivars, PH A applications caused flower stems to wilt faster than the control. In contrast, plants treated with PH V1 revealed significantly slower flower stem senescence compared to the control. Flower wilting during vase life was correlated to a decrease in the K-to-Na ratio in flowers due to an inability to transport K to the flowers from the leaves rather than an increase in Na in the flowers themselves.
Phylogenomics and Systematics of Overlooked Mesoamerican and South American Polyploid Broad-Leaved Festuca Grasses Differentiate F. sects. Glabricarpae and Ruprechtia and F. subgen. Asperifolia, Erosiflorae, Mallopetalon and Coironhuecu (subgen. nov.)

Allopolyploidy is considered a driver of diversity in subtribe Loliinae. We investigate the evolution and systematics of the poorly studied Mesoamerican and South American polyploid broad-leaved Festuca L. species of uncertain origin and unclear taxonomy. A taxonomic study of seven diagnostic morphological traits was conducted on a representation of 22 species. Phylogenomic analyses were performed on a representation of these supraspecific taxa and all other Loliinae lineages using separate data from the entire plastome, nuclear rDNA 45S and 5S genes, and repetitive DNA elements. F. subgen. Mallopetalon falls within the fine-leaved (FL) Loliinae clade, whereas the remaining taxa are nested within the broad-leaved (BL) Loliinae clade forming two separate Mexico–Central–South American (MCSAI, MCSAII) lineages. MCSAI includes representatives of F. sect. Glabricarpae and F. subgen. Asperifolia plus F. superba, and MCSAII of F. subgen. Erosiflorae and F. sect. Ruprechtia plus F. argentina. MCSAII likely had a BL Leucopoa paternal ancestor, MCSAI and MCSAII a BL Meso-South American maternal ancestor, and Mallopetalon FL, American I–II ancestors. Plastome vs. nuclear topological discordances corroborated the hybrid allopolyploid origins of these taxa, some of which probably originated from Northern Hemisphere ancestors. The observed data indicate rapid reticulate radiations in the Central–South American subcontinent. Our systematic study supports the reclassification of some studied taxa in different supraspecific Festuca ranks.
Delivery on Scarred Uterus at Souro Sanou Teaching Hospital, Burkina Faso (about 531 Cases)

Introduction: Therapeutic conduct for delivery via a scarred uterus is con-troversial in modern obstetrics. Some authors recommend a ceasarean section. The purpose of this study was to analyse the conduct and prognosis of delivery via scarred uterus at Souro Sanou Teaching Hospital in Bo-bo-Dioulasso. Methods: We conducted a descriptive cross-sectional study from January 1 to December 31, 2017. Data were collected from medical, birth, and operating room records. Result: In total, 531 scared uterus deliveries and 5293 deliveries have been recorded in our study; the frequency of deliveries via a scarred uterus was 9.96%. The average age of the patients was 28.02 years old, with extremes of 17 and 44 years. The average parity was 2.34, with extremes of 1 and 8. Patients with a spacing interval between births of at least 24 months accounted for 86.6% of observed patients. Patients with a single scar uterus made up 70.6% of the population. There were 349 (65.73%) patients who had an emergency caesarean section during a previous delivery. The trial of vaginal delivery via a scarred uterus was conducted on 182 patients with a success rate of 89.56%. There was no maternal death. However, we noted 23 foetal deaths (4.33%). Conclusion: More than 50% of parturient women with a single caesarean uterine scar who underwent the uterine test gave birth vaginally in our department. However, like most previous studies on the subject, we recommend vaginal delivery in the presence of a prior caesarean-scarred uterus whenever possible.