Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental recognition and home administration of pyrexia in children in a malaria infested region

Fever is one of the most common symptoms of disease in children, accompanies a range of illnesses and is often treated at home before medical attention is sought. An investigation of fever management among parents of children under five was carried out to evaluate parental perception. Parents of 1143 children were randomly selected and interviewed to answer a questionnaire about fever. Majority of parents (63%) perceived fever to be hotness of the body and had no idea of the normal body temperature and so did not use a thermometer. 621 parents representing 54% irrespective of their educational qualification and age suspected malaria as the most likely cause of fever which made them act within 24 h by administering antimalarial drugs at home without medical diagnosis. Parents felt that an untreated fever could result in convulsion (16%) and even death (14%) which informed some harmful practices. The educational level of parents was statistically insignificant (p>0.05) and had no bearing on the knowledge of fever while the age of parents had a strong correlation with their perception and fever management. Based on the outcome of this study, there is a need for appropriate education to prevent the abuse of antimalarial drugs and also to stop some crude and harmful practice employed to arrest a convulsive child.
Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade

Rationale: Wear particle-induced periprosthetic osteolysis (PPO) is a common long-term complication of total joint arthroplasty, and represents the major cause of aseptic loosening and subsequent implant failure. Previous studies have identified the central role of osteoclast-mediated bone resorption in the pathogenesis of PPO. Thus, therapeutic approaches of inhibiting osteoclast formation and activity are considered to be of great potential to prevent and treat this osteolytic disease. Hedgehog (Hh) signaling has been shown to play an important role in promoting osteoblast differentiation and bone formation. While Hh signaling is also implicated in regulating osteoclastogenesis, whether it can directly inhibit osteoclast differentiation and bone resorption remains controversial. Moreover, its potential therapeutic effects on PPO have never been assessed. In this study, we explored the cell-autonomous role of Hh signaling in regulating osteoclastogenesis and its therapeutic potential in preventing wear particle-induced osteolysis. Methods: Hh signaling was activated in macrophages by genetically ablating Sufu in these cells using LysM-Cre or by treating them with purmorphamine (PM), a pharmacological activator of Smoothened (Smo). In vitro cell-autonomous effects of Hh pathway activation on RANKL-induced osteoclast differentiation and activity were evaluated by TRAP staining, phalloidin staining, qPCR analyses, and bone resorption assays. In vivo evaluation of its therapeutic efficacy against PPO was performed in a murine calvarial model of titanium particle-induced osteolysis by μCT and histological analyses. Mechanistic details were explored in RANKL-treated macrophages through Western blot analyses. Results: We found that Sufu deletion or PM treatment potently activated Hh signaling in macrophages, and strongly inhibited RANKL-induced TRAP+ osteoclast production, F-actin ring formation, osteoclast-specific gene expression, and osteoclast activity in vitro. Furthermore, we found that Sufu deletion or PM administration significantly attenuated titanium particle-induced osteoclast formation and bone loss in vivo. Our mechanistic study revealed that activation of Hh signaling suppressed RANKL-induced activation of JNK pathway and downregulated protein levels of two key osteoclastic transcriptional factors, c-Fos and its downstream target NFATc1. Conclusions: Both genetic and pharmacological activation of Hh signaling can cell-autonomously inhibit RANKL-induced osteoclast differentiation and activity in vitro and protect against titanium particle-induced osteolysis in vivo. Mechanistically, Hh signaling hinders osteoclastogenesis partly through suppressing the JNK/c-Fos-NFATc1 cascade. Thus, Hh signaling may serve as a promising therapeutic target for the prevention and treatment of PPO and other osteolytic diseases.
Selection of resting areas by emerging Culicoides impunctatus (Diptera: Ceratopogonidae) on downy birch (Betula pubescens)

Abstract Resting areas utilised by Culicoides impunctatus Goetghebuer on emergence were investigated on downy birch (Betula pubescens) in Argyllshire, Scotland. Trees examined supported large numbers of nulliparous and male C. impunctatus but no parous females, indicating that this stage does not commonly rest in this habitat during the period examined. Areas with high levels of lichen, moss and liverwort cover were preferred as resting sites at times of high C. impunctatus abundance. Males of this species showed greater activity than did females; this, together with the presence of large numbers of unmated females, could suggest that facultative mating or pre-swarm gathering takes place on these tree sites. Results presented are interpreted with regard to both the life-cycle of the species, and their value for advancing future control techniques.
A Single-Center Evaluation of Mid-Term Results of Ponseti Management for Nonidiopathic Congenital Clubfeet in Vietnam

By comparing initial correction, early relapses, latest follow-up mid-term results between idiopathic and nonidiopathic congenital clubfeet, this study is to define the efficacy of the Ponseti method for the nonidiopathic clubfeet. 32 nonidiopathic congenital clubfeet (group 1) in 21 children and 118 idiopathic congenital clubfeet (group 2) in 82 children (newborn to 12 months) are recruited for this study, following treatment with the Ponseti method with a follow-up period of a minimum of two years. The clubfeet are classified and evaluated during casting, of initial correction, and for early relapse according to Dimeglio’s score. The latest follow-up results are evaluated according to Richards’ classification. The initial correction is successfully 81.3% in group 1, and 96.6% in group 2 (p=0.019). The early relapses are 26.9% in group 1, and 7.0% in group 2 (p=0.003); for group 1, 57.1% of early relapses were subjected to medial posterior release and for group 2, all of early relapses were successfully managed by casting (p < 0.001). The latest follow-up results are good 21.9%, fair 46.8%, poor 31.3% in group 1, and good 76.3%, fair 22.0%, poor 1.7% in group 2 (p < 0.001). This study indicates that the Ponseti method is successfully applied to nonidiopathic clubfeet. However, the early relapse rate of nonidiopathic clubfeet is high and most of these relapsing clubfeet need to be managed by posteromedial release. In addition, posteromedial release should be indicated as the initially definite management for very severe clubfeet of arthrogryposis.
INVESTIGATING THE PERSONNEL’S AND STUDENT’S PERSPECTIVES ABOUT THE ETHICALCLIMATE IN HOSPITALS OF ZAHEDAN

Introduction: Nurses face to complicated situations in providing required cares of patients in which to make right and ethical decides in these situations need to positive Ethical climate in hospital. The aim of this study was to investigate the personnel’s and student’s perspectives about the ethical climate in educational hospitals of Zahedan. Procedure: The study is descriptive-analytical which was conducted on 133 participants who had been selected by census. To collect the data, a two-part questionnaire was used that the first part was related to demographic features and second part was ethical climate questionnaire by Olson. The data was analyzed in SPSS 19 software by using statistical tests, variance analysis and t-test. Findings: In this study, 62 students in the operating room and 71 personnel of operating rooms were participated. The relationship age and gender with perceived ethical climate was not significant (P>0.05). The average score of ethical climate in Ali-Ibn-Abitaleb hospital was 3.29, in Khatam hospital was 3.74 and in Alzahra hospital was 3.87. In general, ethical climate in operating rooms of hospitals of Zahedan was reported positive and differences between the ideas of students and personnel were very low. Conclusion: The ethical climate in the operating rooms in educational hospitals of Zahedan is positive from the perspective of the students and personnel but some of the ethical aspects, especially the matters relating to doctors and their relationships with nurses, need to be promoted. Sadegh Zare* et al. International Journal Of Pharmacy & Technology IJPT| June-2016 | Vol. 8 | Issue No.2 | 12368-12378 Page 12369
Information Technology Adoption And The Growth Of Small And Medium Enterprises In Greater Kampala Metropolitan Area, Uganda

: Growth of Small and Medium Enterprises plays a major role in improving a country’s economic development. Whereas research identifies the role played by Information Technology adoption in improving the growth of organizations, much emphasis has been given to understanding large organizations in developed countries. This has left SMEs in developing countries prone to low growth and limited survival in the market with the contemporary competitive business environment. More so, SMEs contribute approximately 20% of GDP in most developing countries. Apparently, due to a weak link between Information Technology adoption and Growth of SMEs. In Uganda, it appears that there is need for a greater emphasis on studies that link information technology adoption and growth of SMEs. In this study a mixed methods approach and cross-sectional research design was used to establish the effect of information technology adoption and growth of small and medium enterprises in greater Kampala metropolitan area on a sample of 189 top administrators of SMEs. Findings revealed approximately a large correlation between information technology adoption and growth of SMEs. Linear regression results revealed that 42.2% of growth of SMEs according to this study was explained by variations in information technology adoption practices. As a result, this study recommends that SMEs ought to take advantage of the existing sophisticated and the ever varying information technologies in order to achieve their ultimate goal which is growth.
Evolution of the Samsung Exynos CPU Microarchitecture

The Samsung Exynos family of cores are highperformance “big” processors developed at the Samsung Austin Research & Design Center (SARC) starting in late 2011. This paper discusses selected aspects of the microarchitecture of these cores - specifically perceptron-based branch prediction, Spectre v2 security enhancements, micro-operation cache algorithms, prefetcher advancements, and memory latency optimizations. Each micro-architecture item evolved over time, both as part of continuous yearly improvement, and in reaction to changing mobile workloads.
Five Maturity Levels of Managing AI: From Isolated Ignorance to Integrated Intelligence

To guide future discussions about managing artificial intelligence (AI), this article suggests an AI management framework with five maturity levels, which are comparable to the five levels of the autonomous driving framework from no automation to complete automation. If companies move beyond Isolated Ignorance (Level 0), they are characterized by an Initial Intent (Level 1), which typically evolves towards an Independent Initiative (Level 2). A more advanced management leads to Interactive Implementation (Level 3) and Interdependent Innovation (Level 4). On this basis, a close combination of AI and human knowledge enables a sustainable competitive advantage with Integrated Intelligence (Level 5). This framework draws on the intelligence-based approach to company performance, and it provides the basis for an AI maturity assessment in organizations. It further helps to identify many firms’ managerial challenges as well as major organizational limitations even in those firms that are often considered as AI leaders.
Divide and Conquer Frontend Bottleneck

The frontend stalls caused by instruction and BTB misses are a significant source of performance degradation in server processors. Prefetchers are commonly employed to mitigate frontend bottleneck. However, next-line prefetchers, which are available in server processors, are incapable of eliminating a considerable number of L1 instruction misses. Temporal instruction prefetchers, on the other hand, effectively remove most of the instruction and BTB misses but impose significant area overhead.Recently, an old idea of using BTB-directed instruction prefetching is revived to address the limitations of temporal instruction prefetchers. While this approach leads to prefetchers with low area overhead, it requires significant changes to the frontend of a processor. Moreover, as this approach relies on the BTB content for prefetching, BTB misses stall the prefetcher, and likely lead to costly instruction misses. Especially as instruction misses are usually more expensive than BTB misses, the dependence of instruction prefetching to the BTB content is harmful to workloads with very large instruction footprints. Moreover, BTB-directed instruction prefetchers, as proposed in prior work, cannot be applied to variable-length ISAs.In this work, we showcase the harmful effects of making instruction prefetchers depend on the BTB content. Moreover, we divide the frontend bottleneck into three categories and use a divide-and-conquer approach to propose simple and effective solutions for each one. Sequential misses can be covered by an accurate and timely sequential prefetcher named SN4L, a lightweight discontinuity prefetcher named Dis eliminates discontinuity misses, and the BTB misses are reduced by pre-decoding the prefetched blocks. We also discuss how our proposal can be used for variable-length ISAs with low storage overhead. Our proposal, SN4L+ Dis+BTB, imposes the same area overhead as the state-of-the-art BTB-directed prefetcher, and at the same time, outperforms it by 5% on average and up to 16%.
Evaluation of the Nutrient Status of Some Hydrophytes in the Water Courses of Nile Delta, Egypt

The nutritive values of three dominant hydrophytes along the water courses in Nile Delta, Egypt (Echinochloa stagnina, Eichhornia crassipes, and Ceratophyllum demersum) were evaluated in terms of estimating their phytomass, organic, and inorganic chemical compositions. Shoots were collected seasonally from 25 permanent stands representing the distribution of the three species along 15 canals and 10 drains distributed in 5 localities within the Nile Delta. Living and dead parts and total phytomass were estimated. Their inorganic (Na, K, Ca, Mg, P, Cu, Mn, and Pb) and organic (carbohydrates, total nitrogen, total protein, ether extract, digestible nutrient, digestible energy, metabolized energy, and net energy) contents were estimated. The vegetative phase of E. stagnina extended during winter, spring, and summer, while it is flowering and fruiting during autumn. On the other hand, E. crassipes and C. demersum attained their maximum flowering during spring and maximum fruiting during summer, while maximum vegetative phase during autumn and winter. E. stagnina had the highest mean annual phytomass, while C. demersum had the lowest. The living parts of C. demersum had the highest concentrations of Na, Ca, and Mg, while the living parts of E. crassipes had the highest of K and N. C. demersum had the ability to accumulate more concentrations of heavy metals than the other studied species. E. crassipes had the highest values of total carbohydrate and total proteins, while E. stagnina had the highest of crude fibers, and C. demersum had the highest of ether extract and ash contents. The living parts of E. crassipes and C. demersum were considered as excellent forages, while the dead parts of all species and the living parts of E. stagnina were evaluated as poor forage.
Capacidade de restabelecimento da grama-estrela-africana após aplicação de glifosato em pré-semeadura de milho

The objective of this work was to evaluate the recovery capacity of African star grass (Cynodon nlemfuensis) after glyphosate application in pre-sowing of corn. A randomized block design was used, with four replicates. The treatments were doses of acid equivalent (a.e.) of the herbicide glyphosate (0, 720, 1,440, 2,160, 2,880, and 3,600 g ha-1) and a hoed control. African star grass is tolerant to the usually recommended doses of the herbicide (720 to 1,080 g ha-1 a.e.). Doses of glyphosate, ranging from 1,232 to 1,439 g ha-1 a.e. suppress the grass, avoid its competition with corn, and allow the recovery of the pasture after the corn harvest.
The Role of Emotional Intelligence in Counterproductive Work Behavior

The purpose of the present research is to investigate the role of emotional intelligence in counterproductive work behavior in the Local Government Organizations. The relationship between counterproductive work behavior, emotional intelligence and job satisfaction is also explored. A quantitative empirical survey was conducted in the public sector and especially in the Municipality of Chalkida, in Greece. The research findings have shown that job satisfaction has a negative correlation with counterproductive work behavior and positive correlation with emotional intelligence. Additionally, counterproductive work behavior & emotional intelligence are influenced by age. Emotional intelligence has high score among the employees of the Municipality of Chalkida and this indicates a low tendency to exhibit counterproductive work behavior. The generalisation of the findings are potential limited by the fact that the sample consisted only of employees within a particular local government. Ebracing such surveys by local governments will be of use to resources management strategies and plans so as to improve human resources performance and create a work environment that is as optimal as possible. Additionally, they will improve citizens service and that will lead to a better reputation and value of the public organisations. The present study contributes to the literature on emotional intelligence and counterproductive work behavior in the work place by investigating the relationship between them.
Ginsenosides in American Ginseng: Comparison of in vitro Derived and Field-Grown Plant Tissues

ABSTRACT Ginsenoside content and profiles were evaluated in plant tissues of field and in vitro grown American ginseng (Panax quinquefolius L.). The six major ginsenosides, Rg1, Rc, Rb1, RC, Rb2 and Rd were present in all materials tested. The total ginsenoside content of two-year-old roots was 31 mg/g dry matter, with Rb1 and Re as the main ginsenosides. Although in vitro grown materials such as callus and somatic embryo-derived plantlets contained relatively lower total ginsenosides, somatic embryo-derived plantlets had two-fold higher level of ginsenosides than the embryogenic callus. The two-month-old, zygotic embryo-derived, in vitro grown seedlings contained 24.4 mg/g total ginsenosides. In addition, higher Re, Rb2 and Rd were observed in zygotic embryo-derived seedlings than in the two-year-old roots of field grown plants, indicating a potential for producing high-quality ginsenoside products under controlled culture conditions.
Impact of cefotaxime on Agrobacterium mediated BT gene transformation in sugarcane

Complete elimination of Agrobacterium from plant regeneration media is essential for the successful recovery of putative transgenic sugarcane plantlets. The present investigation determines the eco-friendly cefotaxime concentration for the inhibition of Agrobacterium during co cultivation with sugarcane leaf disc explants. The disk diffusion assay with eight different concentration of cefotaxime viz; 0 (Control), 50, 100, 150, 200, 250, 300 and 350 mg /l were used in Yeast Extract Manitol (YEM) medium. Agrobacterium tumefaciens LBA 4404 strain harboring plasmid pBINAR, carried the selectable marker gene (npt II) for kanamycin. Out of these concentrations, cefotaxime @ 150 mg/l was found eco-friendly dose to suppress the growth of Agrobacterium tumefaciens and produced a vigorous shoots. Plant allows non-phytotoxic regeneration and survival rate was also good on this concentration. Consequently, the efficient protocol established in this study could be applicable for suppressing Agrobacterium tumefactions in further genetic transformation works of sugarcane.
ISOLATION, PURIFICATION, AND CHARACTERIZATION OF DMSP LYASE (DIMETHYLPROPIOTHETIN DETHIOMETHYLASE (4.4.1.3)) FROM THE RED ALGA POLYSIPHONIA PANICULATA1

Polysiphonia paniculata Montagne is an intertidal red alga known to produce large amounts of the compound dimethylsulfoniopropionate (DMSP). Conversion of this substrate into dimethylsulfide is accomplished in P, paniculata by an enzyme called DMSP lyase (dimethylpropiothetin dethiomethyla.se (4.4.1.3)). DMSP lyase has been purified and characterized from P. paniculata. Enzymie activity is found in two different proteins: the larger with a molecular weight of 9.26 ± 104 daltons and the smaller with a molecular weight of 3.65 ± 104 daltons. Specific activity of the enzyme is 526 μmols min−1mg−1 for the smaller protein a nd 263 μmols min −1 mg−1 for the la rger protein. The Michaelis‐Menten constant (Km) is 72.8 μM ± 17.15 and the vmax is 1.62 μmols min−1± 0.928 for the 92.6‐kDa protein. The p1 of the larger protein is 5.8 and 5.9 for the smaller protein. Interaction with cysteine protease inhibitors L‐trans‐epoxysuccinyl‐leucylamido (4‐guanidino)‐butane, dithiobis‐(2‐nitrobenzoate), or N‐ethylmaleimide inactivated enzyme activity. The presence of either magnesium or calcium with DMSP lyase enhanced activity al concentrations between 20 and 40 μM but had little effect above these levels. Addition of the divalent chelators ethylenebis(oxyethylenenitrilo) tetraacetic acid and ethylenediaminetetraacetate decreased activity of the enzyme, but activity was restored when either chelator was removed and magnesium or calcium was added to the enzyme.
The Effect Of Service Quality And Hospital Image, Patient Trust And Patient Values On Patient Satisfaction And Loyalty In Sakura / Teratai Pavilion Of A.W. Sjahranie Hospital

The purpose of this study was to analyze the effect of service quality on patient satisfaction, hospital image on patient satisfaction, trust influences patient satisfaction, patient value influences patient satisfaction, service quality influences patient loyalty, hospital image influences patient loyalty, trust influence patient loyalty, patient value influences patient loyalty, and patient satisfaction affects patient loyalty in hospitalization. Population in this research is patient in sakura/teratai pavilion of A.W. Sjahranie Hospital with total of 230 respondents. Data collection techniques using Questionnaire with Likert scale, and data analysis techniques using the Structural Request Model Partial Least Square (SEM-PLS) approach to determine the effect between indicators and constructs and the result variance of the dependent variable.The results showed that service quality has no significant effect on patient satisfaction. Hospital image has no significant effect on patient satisfaction. Patient trust has no significant effect on patient satisfaction, patient value has a significant effect on patient satisfaction, service quality has no significant effect on patient loyalty, hospital image has a significant effect on loyalty, trust service has no significant effect on patient loyalty, service value has a significant effect on patient loyalty , patient satisfaction has no significant effect on patient loyalty in sakura/teratai pavilion of A.W. Sjahranie Hospital