Miracle-dz/UniFAR-FTUs huggingface dataset:
Agility of enterprise information systems: A conceptual model, design principles and quantitative measurement

Yuri A. Zelenkov - Professor, Department of Information Systems and Digital Infrastructure Management, National Research University Higher School of EconomicsAddress: 20, Myasnitskaya Street, Moscow, 101000, Russian FederationE-mail: yzelenkov @hse.ru A modern enterprise has to react to permanent changes in the business environment by transformation of its own behavior, operational practices and business processes. Such transformations may range from changes of business processes to changes of information systems used to support the business processes, changes in the underlying IT infrastructures and even in the enterprise information system as a whole. The main characteristic of changes in a turbulent business environment and, consequently, in the enterprise information system is unpredictability. Therefore, an enterprise information system should support the operational efficiency of the current business model, as well as provide the necessary level of agility to implement future unpredictable changes of requirements. This article aims to propose a conceptual model of an agile enterprise information system, which is defined as a working system that should eliminate the largest possible number of gaps caused by external events through incremental changes of its own components. A conceptual model developed according to the socio-technical approach includes structural properties of an agile enterprise information system (actors, tasks, technology, and structure). Structural properties define its operational characteristics, i.e. measurable indicators of agility - time, costs, scope and robustness of process of change. Different ways to build such an agile system are discussed on the basis of axiomatic design theory. We propose an approach to measurement of time, cost, scope and robustness of changes which helps to make quantitative estimation of the achieved level of agility.
Home Wi-Fi Impairments

The preferred method to access Internet from home is Wi-Fi. Unfortunately poorly placed Wi-Fi access point can experience Wi-Fi impairments such as interference or congestion, leading to degraded Internet performance. Identifying these impairments can be challenging, even for wireless experts. To approach this challenge we develop a tool to identify home Wi-Fi impairments. In our work we conduct experiments triggering wireless and non-wireless issues in a testbed. The two methods we work with are active probing and passive wireless metrics collection from wireless AP and wireless client. The wireless metrics we collect include but are not limited to, RSSI, PHY Rate, Noise, etc. With these metrics we get a sense of the status of home Wi-Fi and correlate it with our active probing results. Finally, to identify a wireless impairment we run our dataset through supervised learning algorithms. We obtain the best results with random forest algorithm. Random forest is well known for its precision to classify events based on a speciﬁc set of features. We close our paper by presenting the results of home Wi-Fi impairment detection by modeling it as a classiﬁcation problem.
Haufler, Andreas und Wooton, Ian: Regional Tax Coordination and Foreign Direct Investment

This paper analyses the effects of a regionally coordinated corporate income tax in a model with three active countries, one of which is not part of the union, and a globally mobile firm. We show that regional tax coordination can lead to two types of welfare gain. First, for investments that would take place in the union in the absence of coordination, a coordinated tax increase can transfer location rents from the firm to the union. Second, by internalising all of the union’s benefits from foreign direct investment, a coordinated tax reduction can attract more welfareenhancing investment than when member states act in isolation. Depending on which motive dominates, tax levels may thus rise or fall under regional coordination.
PEDOLOGICAL AND FLORAL ASSESSMENT OF SHINGHAR VALLEY (DISTRICT ZHOB) THROUGH MULTIVARIATE TOOLS

The distribution of herbaceous plant species and effect of edaphic factors on species distribution was studied to build a correlation between the herbaceous species and environmental parameter through multivariate techniques. Three zones were formed on the basis of forest (Pinus gerardiana) density. Herbaceous vegetation was sampled, identified and classified through Two Way Indicator Species Analysis (TWINSPAN). Soil was analyzed for organic matter, electrical conductivity, pH, moisture content and heavy metals (lead, nickel, copper and zinc). Canonical Correspondence Analysis (CCA) was employed to correlate species diversity and edaphic factors, soil organic matter and zinc content was found to be most overruling edaphic factor in the distribution patterns of herbage. The study will be helpful in conservation and better management of native flora.
Localization of Members of the g -Glutamyl Transpeptidase Family Identiﬁes Sites of Glutathione and Glutathione S -Conjugate Hydrolysis

g -Glutamyl transpeptidases (GGTs) are essential for hydrolysis of the tripeptide glutathione ( g -glutamate-cysteine-glycine) and glutathione S -conjugates since they are the only enzymes known to cleave the amide bond linking the g -carboxylate of glutamate to cysteine. In Arabidopsis thaliana , four GGT genes have been identiﬁed based on homology with animal GGTs. They are designated GGT1 (At4g39640), GGT2 (At4g39650), GGT3 (At1g69820), and GGT4 (At4g29210). By analyzing the expression of each GGT in plants containing GGT: b -glucuronidase fusions, the temporal and spatial pattern of degradation of glutathione and its metabolites was established, revealing appreciable overlap among GGTs. GGT2 exhibited narrow temporal and spatial expression primarily in immature trichomes, developing seeds, and pollen. GGT1 and GGT3 were coexpressed in most organs/ tissues. Their expression was highest at sites of rapid growth including the rosette apex, ﬂoral stem apex, and seeds and might pinpoint locations where glutathione is delivered to sink tissues to supplement high demand for cysteine. In mature tissues, they were expressed only in vascular tissue. Knockout mutants of GGT2 and GGT4 showed no phenotype. The rosettes of GGT1 knockouts showed premature senescence after ﬂowering. Knockouts of GGT3 showed reduced number of siliques and reduced seed yield. Knockouts were used to localize and assign catalytic activity
Opioid-induced Hyperalgesia in a Murine Model of Postoperative PainRole of Nitric Oxide Generated from the Inducible Nitric Oxide Synthase

Background: Opioid-induced delayed hyperalgesia and allodynia have been reported in human and animal models. The authors evaluated the influence of different opioids used during clinical anesthesia on nociceptive sensitivity and incisional pain in mice. The role of the inducible nitric oxide synthase on surgical pain and opioid-induced pronociception also was investigated. Methods: CD1 mice were used to study the efficacy of opioids inducing pronociception and enhancing incisional pain. The implication of nitric oxide generated from the inducible nitric oxide synthase was investigated using knockout mice (C57/BL6) for its gene. Mice underwent right hind paw surgery under sevoflurane anesthesia combined with subcutaneous administration of saline or the opioids fentanyl (0.05 mg/kg), alfentanil (1 mg/kg), and remifentanil (0.04 mg/kg). Nociception was evaluated daily for 7 days using paw-pressure, plantar, and von Frey tests. Results: The antinociceptive effect of opioids was followed by long-lasting thermal hyperalgesia and mechanical allodynia (each lasting between 2 and 7 days), but not mechanical hyperalgesia. Intraoperative infusion of opioids significantly enhanced incisional pain in all tests. The most prominent effects were observed with remifentanil. The inducible nitric oxide synthase gene deletion attenuated both remifentaniland incision-induced pronociceptive effects. In mutant mice for the inducible nitric oxide synthase gene, remifentanil was still efficient in enhancing incisional pain, but the global pronociceptive effect was attenuated significantly as compared with wildtype mice. Conclusions: The authors’ study demonstrates that the intraoperative administration of fentanyl or remifentanil enhances the extent and duration of postoperative pain. The results suggest a role of the nitric oxide systems in the cause of acute postoperative pain and opioid-induced pronociception.
On the nature of the excitation of the Herbig-Haro object 2.

VLA observations of the NH 3 (1, 1) and NH 3 (2, 2) lines toward the HH 2 object using the D configuration are presented. Several small (∼20) clumps located near HH 2 are detected. These clumps are cold, T R (2, 2; 1, 1) ≤20 k, and with narrow line widths, ΔV ≤ 1 km/s. It is found that these clumps appear a few arcseconds downwind with respect to the HH 2 optical knots and the H 2 [S(1), v = 1→0] line emission. The low temperatures and narrow line widths found in the ammonia clumps imply that they cannot be ambient clump compressed as a whole by a shock wave
Title : Genomic and Virological Characterization of SARS-CoV-2 Variants in a Subset of 1 Unvaccinated and Vaccinated U . S . Military Personnel 2

17 The emergence of SARS-CoV-2 variants complicates efforts to control the COVID-19 18 pandemic. Increasing genomic surveillance of SARS-CoV-2 is imperative for early detection of 19 emerging variants, to trace the movement of variants, and to monitor effectiveness of 20 countermeasures. Additionally, determining the amount of viable virus present in clinical 21 for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this this version posted December 16, 2021. ; https://doi.org/10.1101/2021.12. 16.21267862 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. samples is helpful to better understand the impact these variants have on viral shedding. In this 22 study, we analyzed nasal swab samples collected between March 2020 and early November 2021 23 from a cohort of United States (U.S.) military personnel and healthcare system beneficiaries 24 stationed worldwide as a part of the Defense Health Agency’s (DHA) Global Emerging 25 Infections Surveillance (GEIS) program. SARS-CoV-2 quantitative real time reverse26 transcription PCR (qRT-PCR) positive samples were characterized by next-generation 27 sequencing and a subset was analyzed for isolation and quantification of viable virus. Not 28 surprisingly, we found that the Delta variant is the predominant strain circulating among U.S. 29 military personnel beginning in July 2021 and primarily represents cases of vaccine 30 breakthrough infections (VBIs). Among VBIs, we found a 50-fold increase in viable virus in 31 nasal swab samples from Delta variant cases when compared to cases involving other variants. 32 Notably, we found a 40-fold increase in viable virus in nasal swab samples from VBIs involving 33 Delta as compared to unvaccinated personnel infected with other variants prior to the availability 34 of approved vaccines. This study provides important insight about the genomic and virological 35 characterization of SARS-CoV-2 isolates from a unique study population with a global presence. 36
AREGU June 45/6

Scrogin, Karie E. , Eugene T. Grygielko, and Virginia L. Brooks. Osmolality: a physiological long-term regulator of lumbar sympathetic nerve activity and arterial pressure. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1579–R1586, 1999. —Acute infusion of hypertonic fluid increases mean arterial pressure (MAP) in part by elevating nonrenal sympathetic activity. However, it is not known whether chronic, physiological increases in osmolality also increase sympathetic activity. To test this hypothesis, MAP, heart rate (HR), and lumbar sympathetic nerve activity (LSNA) were measured in conscious, 48-h water-deprived rats (WD) during a progressive reduction in osmolality produced by a 2-h systemic infusion (0.12 ml/min) of 5% dextrose in water (5DW). Water deprivation significantly increased osmolality (308 6 2 vs. 290 6 2 mosmol/kgH2O, P , 0.001), HR (453 6 7 vs. 421 6 10 beats/min, P , 0.05), and LSNA (63.5 6 1.8 vs. 51.9 6 3.8% baroreflex maximum, P , 0.01). Two hours of 5DW infusion reduced osmolality (215 6 5 mosmol/kgH2O), LSNA (223 6 3% baseline), and MAP (210 6 1 mmHg). To evaluate the role of vasopressin in these changes, rats were pretreated with a V1-vasopressin receptor antagonist. The antagonist lowered MAP (25 6 1 mmHg) and elevated HR (32 6 7 beats/min) and LSNA (11 6 3% baseline) in WD (P , 0.05), but not in water-replete, rats. 5DW infusion had a similar cumulative effect on all variables in V1-blocked WD rats, but had no effect in water-replete rats. Infusion of the same volume of normal saline in WD rats did not change osmolality, LSNA or MAP. Together these data indicate that, in dehydrated rats, vasopressin supports MAP and suppresses LSNA and HR and that physiological changes in osmolality directly influence sympathetic activity and blood pressure independently of changes in vasopressin and blood volume.
Lee, Weon-Young and Shaw, Ian (2014) The impact of out of pocket payments on health care inequality: the case of national health insurance in South Korea

The global financial crisis of 2008 has led to the reinforcement of patient cost sharing in health care policy. This study aimed to explore the impact of direct out-of pocket payments (OOPs) on health care utilization and the resulting financial burden across income groups under the South Korean National Health Insurance (NHI) program with universal population coverage. We used the fourth Korean National Health and Nutrition Examination Survey (KNHNES-IV) and the Korean Household Income and Expenditure Survey (KHIES) of 2007, 2008 and 2009. The Horizontal Inequity Index (HIwv) and the average unit OOPs were used to measure income-related inequity in the quantitative and qualitative aspects of health care utilization, respectively. For financial burden, the incidence rates of catastrophic health expenditure (CHE) were compared across income groups. For outpatient and hospital visits, there was neither pro-poor or pro-rich inequality. The average unit OOPs of the poorest quintile was approximately 75% and 60% of each counterpart in the richest quintile in the outpatient and inpatient services. For the CHE threshold of 40%, the incidence rates were 5.7%, 1.67%, 0.72%, 0.33% and 0.27% in quintiles I (the poorest quintile), II, III, IV and V, respectively. Substantial OOPs under the NHI are disadvantageous, particularly for the lowest income group in terms of health care quality and financial burden. OPEN ACCESS Int. J. Environ. Res. Public Health 2014, 11 7305
COPD_A_330674 2735..2740

1Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea; 2Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea Purpose: Chronic obstructive pulmonary disease (COPD) imposes a major healthcare burden. A tight junction protein, claudin-4 (CLDN4), may play a protective role in acute lung injury, but its role in COPD is unclear. To investigate the relationship between CLDN4 and COPD, we evaluated the association of CLDN4 with the clinical parameters of COPD, including exacerbations. Patients and Methods: We analyzed a cohort of 30 patients with COPD and 25 healthy controls and evaluated their clinical parameters, including lung function. The plasma CLDN4 level in stable and exacerbated COPD was measured. Results: The COPD patients were all males and predominantly smokers; their initial lung function was poorer than the healthy controls. The mean CLDN4 plasma level was 0.0219 ± 0.0205 ng/mg in the control group, 0.0086 ± 0.0158 ng/mg in the stable COPD group (COPD-ST) and 0.0917 ± 0.0871 ng/mg in the exacerbated COPD (COPD-EXA) group. The plasma CLDN4 level was significantly lower in the COPD-ST than the control group, but was significantly elevated in the COPD-EXA group. The plasma CLDN4 level was inversely correlated with forced vital capacity and forced expiratory volume in 1 second in the COPD-EXA group (r=0.506, P=0.001 and r=0.527, P<0.001, respectively). Conclusion: The plasma CLDN4 level is closely correlated with COPD exacerbations and decreased lung function. This suggests that CLDN4 has potential as a severity marker for COPD.
The IFNL 4 gene is a non-canonical interferon gene with a unique but 1 evolutionarily conserved regulation 2 3

23 Interferon lambda 4 (IFNL4) is a recently identified enigmatic member of the 24 interferon lambda family. Genetic data suggest that the IFNL4 gene acts in a pro-viral 25 and anti-inflammatory manner in patients. However, the protein is in vitro 26 indistinguishable from the other members of the interferon lambda family. We have 27 investigated the gene regulation of IFNL4 in detail and found that it differs radically 28 from that of canonical antiviral interferons. Being induced by viral infection is a 29 defining characteristic of interferons, but viral infection or overexpression of 30 members of the interferon regulatory factor (IRF) family of transcription factors only 31 leads to a minute induction of IFNL4. This behavior is evolutionarily conserved and 32 can be reversed by inserting a functional IRF3 binding site into the IFNL4 promoter. 33 Thus, the regulation of the IFNL4 gene is radically different and might explain some 34 of the atypical phenotypes associated with the IFNL4 gene in humans. 35
Melatonin de ciency decreases brown adipose tissue acute thermogenic capacity in rats measured by 18F-FDG PET

Bruno Halpern (  brunohalpern@hotmail.com ) Universidade de Sao Paulo Hospital das Clinicas https://orcid.org/0000-0003-0973-5065 Marcio C Mancini Universidade de Sao Paulo Hospital das Clinicas Caroline Mendes Universidade de Sao Paulo Instituto de Ciencias Biomedicas Camila Maria Longo Machado Universidade de Sao Paulo Hospital das Clinicas Silvana Prando Universidade de Sao Paulo Hospital das Clinicas Marcelo Tatit Sapienza Universidade de Sao Paulo Hospital das Clinicas Carlos Alberto Buchpiguel Universidade de Sao Paulo Hospital das Clinicas Fernanda Gaspar do Amaral Universidade Federal de Sao Paulo José Cipolla-Neto Universidade de Sao Paulo Instituto de Ciencias Biomedicas
OTT_A_272222 2363..2378

*These authors contributed equally to this work Introduction: This bioinformatic study confirmed a new miRNA-mRNA regulatory network and a prognostic signature in endometrial cancer (EC). Materials and Methods: We downloaded RNA-seq and miRNA-seq data of EC from the TCGA database, then used EdegR package to screen differentially expressed miRNAs and mRNAs (DE-miRNAs and DE-mRNAs). Then, we constructed a regulatory network of ECassociated miRNAs and hub genes by Cytoscape, and determined the expression of unexplored miRNAs in EC tissues and normal adjacent tissues by quantitative Real-Time PCR (qRT-PCR). A prognostic signature model and a predictive nomogram were constructed. Finally, we explored the association between the prognostic model and the immune cell infiltration. Results: A total of 11,531 DE-mRNAs and 236 DE-miRNAs, as well as 275 and 118 candidate DEGs for upregulated and downregulated DE-miRNAs were screened out. The miRNA-mRNA network included 5 downregulated and 13 upregulated DE-miRNAs. qRTPCR proved that the expression levels of miRNA-18a-5p, miRNA-18b-5p, miRNA-449c-5p and miRNA-1224-5p and their target genes (NR3C1, CTGF, MYC, and TNS1) were consistent with our predictions. Univariate and multivariate Cox proportional hazards regression analyses of the hub genes revealed a significant prognostic value of NR3C1, EZH2, AND GATA4, and these genes were closely related to eight types of immune infiltration cells. Conclusion: We identified three genes as candidate biomarkers for EC, which may provide a theoretical basis for targeted therapy.
Smoking Behavior in Low- and High-Income Adults Immediately Following California Tobacco Increase.

Objective: To compare the association of California Proposition 56 (Prop 56), which increased the cigarette tax by $2 per pack beginning on April 1, 2017, with smoking behavior among low-income and high-income adults. Methods: Drawing on a sample of 17,206 low-income and 21,324 high-income adults aged 21 years or older from the 2012 to 2018 California Behavioral Risk Factor Surveillance System data , we explored two outcomes: current smoking prevalence and smoking intensity (average number of cigarettes per day among current smokers). For each income group, we estimated a multivariable logistic regression to analyze the association of Prop 56 with smoking prevalence and a multivariable linear regression to analyze the association of Prop 56 with smoking intensity. Results: Although we observed no association between smoking intensity and Prop 56, we found a statistically significant decline in smoking prevalence among low-income adults following Prop 56. No such association was found among the high-income group. Conclusion. Given that low-income Californians smoke cigarettes at greater rates than those with higher incomes, our results provide evidence that Prop 56 is likely to reduce income disparities in cigarette smoking in California.
AENDO May 41/5

Dyck, D. J., D. Miskovic, L. Code, J. J. F. P. Luiken, and A. Bonen. Endurance training increases FFA oxidation and reduces triacylglycerol utilization in contracting rat soleus. Am J Physiol Endocrinol Metab 278: E778–E785, 2000. —We examined the effects of 8 wk of intense endurance training on free fatty acid (FFA) transporters and metabolism in resting and contracting soleus muscle using pulse-chase procedures. Endurance training increased maximal citrate synthase activity in red muscles (154 to 191%; P # 0.05) but failed to increase cytosolic fatty acid binding protein content, mRNA for fatty acyl-CoA synthase, and the putative FFA transporters or transport of palmitic acid into giant sarcolemmal vesicles. At rest, only triacylglycerol (TG) synthesis was significantly increased by training (1100.9 6 8.7 vs. 166.6 6 6.7 nmol/g wet wt; P # 0.05). Muscle contraction increased TG synthesis (146%; P # 0.05) and palmitate oxidation (1115%; P # 0.05) in untrained rats. Endurance training further enhanced synthesis of monoacylglycerol (MG), diacylglycerol (DG) and TG during contraction (136, 169 and 171%, respectively; P # 0.05), as well as exogenous palmitate oxidation (141%; P # 0.05) relative to untrained rats. Compared with those in untrained rats, TG breakdown and oxidation during contraction were reduced after training by 49 and 30%, respectively (P # 0.05). In conclusion, endurance training 1) increases FFA oxidation and incorporation into endogenous lipid pools during contraction and 2) reduces the rate of intramuscular TG utilization during contraction when exogenous FFA availability is adequate. The enhanced FFA uptake subsequent to training appears to be independent of altered maximal transport rates of FFA into the muscle cell.