Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of information about the benefits and harms of mammography on women’s decision making: The InforMa randomised controlled trial

Background In Spain, women invited to breast screening are not usually informed about potential harms of screening. The objective of the InforMa study is to assess the effect of receiving information about the benefits and harms of breast screening on informed choice and other decision-making outcomes, in women approaching the age of invitation to mammography screening. Methods Two-stage randomised controlled trial. In the first stage, 40 elementary territorial units of the public healthcare system were selected and randomised to intervention or control. In the second stage, women aged 49-50 years were randomly selected. The target sample size was 400 women. Women in the intervention arm received a decision aid (DA) with detailed information on the benefits and harms of screening. Women in the control arm received a standard leaflet that did not mention harms and recommended accepting the invitation to participate in the Breast Cancer Screening Program (BCSP). The primary outcome was informed choice, defined as adequate knowledge and intentions consistent with attitudes. Secondary outcomes included decisional conflict, worry about breast cancer, time perspective, opinions about the DA or the leaflet, and participation in the BCSP. Results In the intervention group, 23.2% of 203 women made an informed choice compared to only 0.5% of 197 women in the control group (p < 0.001). Attitudes and intentions were similar in both study groups with a high frequency of women intending to be screened, 82.8% vs 82.2% (p = 0.893). Decisional conflict was significantly lower in the intervention group. No differences were observed in confidence in the decision, anxiety, and participation in BCSP. Conclusions Women in Spain lack knowledge on the benefits and harms of breast screening. Providing quantitative information on benefits and harms has produced a considerable increase in knowledge and informed choice, with a high acceptance of the informative materials. Trial registration Trial identifier NCT03046004 at ClinicalTrials.gov registry. Registered on February 4 2017. Trial name: InforMa study.
Liquefaction Resistance of Sand Mixed with Fines-Grained for Reclaimed Land

Liquefaction due to earthquakes can cause collapse, subsidences, landslides, lateral spreading, and sand boiling. The damage is commonly occurred at layer of water-saturayed granular sedimen with low relative density. Reclamation areas formed by loose sand are areas with high risk to liquefaction, such as damages occured in the reclamation area of Tokyo Bay Area (Fukushima Earthquake, 2011) and Wellington Port (New Zealand Earthquake, 2016). Some researches have stated that the gradation of soil grains, relative density and maximum acceleration of an earthquake affected the soil’s resistance to liquefaction. This paper presents the results of the experimental studies about the influence of fines-grained in the sand that has liquefaction potential which is used as a reclamation material to review its resistance to liquefaction. The experimental studies were carried out by adding fines-grained. A mixture of sand with fines-grains was made at a relative density of 25%, 50% and 75% under earthquake load with a maximum acceleration of 0.3g. Experimental results show that the increase in the fines content up to 30% and the relative density up to 75% reduces the resistance to liquefaction of the sand–fines mixture. The liquefaction resistance increases well as the increase of fines-grained and relative density.
Global Climate Change as a Driver of Bottom-Up and Top-Down Factors in Agricultural Landscapes and the Fate of Host-Parasitoid Interactions

Global climate is rapidly changing and its evidence is increasingly manifesting across various biological systems. For arthropods, several studies have demonstrated how changing climates affect their distribution through phenological and physiological responses, largely focusing on various organismal fitness parameters. However, the net-effect of changing climate among ecological communities may be mediated by the feedback pathways among interacting trophic groups under environmental change. For agroecosystems, the maintenance of the integrity of trophic interactions even under climate variability is a high priority. This is even more important in this era where there is advocacy for sustainable agriculture, with higher emphasis on environmentally benign methods. For this reason, pest management in food production systems using biological control (especially use of parasitoid antagonists) has come to the fore. In this review, we highlight how climate change may modify bottom-up and top-down factors among agroecosystems with a particular focus on plant-insect host-parasitoid tritrophic interactions. We also outline how habitat management may influence arthropod population dynamics and how it can be manipulated to improve on-farm climate resilience and parasitoid conservation. In addition, we also give an overview of the diversity of physiological responses among host insect and parasitoid populations and how this may influence their interactions. We wrap-up by highlighting how the application of knowledge of conservation biodiversity, designing of multifunctional resilient landscapes and evolutionary physiology of arthropods under thermal stress may be used to improve the fitness of mass-reared parasitoids (in or ex situ) for improvement in efficacy of parasitoids ecosystem services under thermally stressful environments
Efficacy and Tolerance of Post-operative Hypo-Fractionated Stereotactic Radiotherapy in a Large Series of Patients With Brain Metastases

Purpose: The aim of this study was to assess, in a large series, the efficacy and tolerance of post-operative adjuvant hypofractionated stereotactic radiation therapy (HFSRT) for brain metastases (BMs). Materials and Methods: Between July 2012 and January 2017, 160 patients from 2 centers were operated for BM and treated by HFSRT. Patients had between 1 and 3 BMs, no brainstem lesions or carcinomatous meningitis. The primary endpoint was local control. Secondary endpoints were distant brain control, overall survival (OS) and tolerance to HFSRT. Results: 73 patients (46%) presented with non-small cell lung cancer (NSCLC), 23 (14%) had melanoma and 21 (13%) breast cancer. Median age was 58 years (range, 22–83 years). BMs were synchronous in 50% of the cases. The most frequent prescription regimens were 24 Gy in 3 fractions (n = 52, 33%) and 30 Gy in 5 fractions (n = 37, 23%). Local control rates at 1 and 2 years were 88% [95%CI, 81–93%] and 81% [95%CI, 70–88%], respectively. Distant control rate at 1 year was 48% [95%CI, 81–93%]. In multivariate analysis, primary NSCLC was associated with a significant reduction in the risk of death compared to other primary sites (HR = 0.57, p = 0.007), the number of extra-cerebral metastatic sites (HR = 1.26, p = 0.003) and planning target volumes (HR = 1.15, p = 0.012) were associated with a lower OS. There was no prognostic factor of time to local progression. Median OS was 15.2 months [95%CI, 12.0–17.9 months] and the OS rate at 1 year was 58% [95% CI, 50–65%]. Salvage radiotherapy was administered to 72 patients (45%), of which 49 received new HFSRT. Ten (7%) patients presented late grade 2 and 4 (3%) patients late grade 3 toxicities. Thirteen (8.9%) patients developed radiation necrosis. Conclusions: This large multicenter retrospective study shows that HFSRT allows for good local control of metastasectomy tumor beds and that this technique is well-tolerated by patients.
Risk Assessment User Interface Design’s by using Object Orientation Programming Approximation in Wooden Toys Industry

Supply chain is a group of companies that work together to create and deliver products to end users [7]. Whereas supply chain risk is defined as an imbalance between demand and supply. Supply chain disruptions can cause various problems such as length of waiting time, out of stock, inability to meet customer demand, and rising costs [1]. If supply chain risk occurs, it will certainly cause material and non-material losses. To anticipate this loss, proper supply chain risk management is essential. In this study, the author developed [11] research entitled “Risk Management Analysis Using FMECA and ANP Methods in the Supply Chain of Wooden Toy Industry”, IOP Conference Series: Materials Science and Engineering, 2019 “The development carried out by the author is” Risk Assessment User Interface Design’s by using Object Orientation Programming Approximation in Wooden Toys Industry” aims to build information systems so that users more easily determine the greatest risk in the company and can minimize the impact of risks that may occur so that it is more effective and efficient . There are 6 risk factors with 25 risk variables from the data questionnaire results [11] and the biggest risk factor is eviroment with marcoeconomic variable risk of 518, 778.
A Smartphone Game to Prevent HIV Among Young Africans: Protocol for a Randomized Pilot Study of a Mobile Intervention

Background Young people aged under 25 years make up an increasing proportion of the population in emerging economies such as Kenya, where half of new adult HIV infections are among 15- to 24-year olds. Interventions targeting this age group have the potential to avert HIV infections among an increasingly large at-risk population. Interactive communication technologies offer a promising platform for reaching young people in engaging ways. Objective Tumaini is a narrative-based smartphone game designed to help young Africans protect themselves from HIV. The objective of this study was to pilot test the game, focusing on the data needed to inform a future randomized controlled efficacy trial, including assessments of study feasibility and safety. Methods The study took place in Kisumu Town, western Kenya, in spring 2017. The game-based intervention was pilot tested for 16 days with a sample of 60 preadolescents aged 11 to 14 years. Participant recruitment was initiated through schools. Participants were randomly assigned to the control or intervention arms of the study. One parent for each of the intervention arm participants was also recruited (n=30). The intervention arm participants were provided with smartphones on which Tumaini was loaded so that they could play the game at home. Youth completed behavioral surveys at baseline, posttest, and 6-week follow-up. The intervention arm participants provided quantitative feedback on their experience of the game-based intervention at posttest. They and their parents further participated in postintervention focus group discussions. Feasibility-related study metrics were collected on recruitment, enrollment, attrition, safety of participants, and return of phones. Results Recruitment and enrollment of the 60 preadolescents and parents were successfully completed within 18 days. No participants were lost to follow-up: all youth completed all 3 waves of the survey and 27 intervention arm youth and 22 parents and caregivers participated in the focus groups. No safety concerns were reported. All phones were returned after the intervention period; none were damaged or lost. All intervention arm participants initiated gameplay, recording a mean exposure time just under 27 hours. Conclusions Findings indicate that it is feasible and safe to test a smartphone-based HIV prevention intervention for very young adolescents in urban and peri-urban sub-Saharan Africa by initiating recruitment in schools and temporarily providing youth participants with smartphones on which the game is loaded. A randomized controlled trial powered to assess the efficacy of the game-based intervention is being designed to be carried out in the same geographic area as the pilot, using similar methods. Trial Registration ClinicalTrials.gov NCT03054051; https://clinicaltrials.gov/ct2/show/NCT03054051 (Archived by WebCite at http://www.webcitation.org/6wjwpX8Bg.) International Registered Report Identifier (IRRID) DERR1-10.2196/11209
Exchange-protein activated by cAMP (EPAC) regulates L-type calcium channel in atrial fibrillation of heart failure model.

OBJECTIVE Both atrial fibrillation (AF) and heart failure (HF) are increasingly prevalent and related to high hospitalization rate and mortality. AF is a cause as well as a consequence of HF, with complicated interactions resulting in impairment of cardiac systolic and diastolic function. Conversely, the complex structural and neurohormonal alterations in HF contribute to the occurrence and development of AF. However, the molecular mechanism remains unclear. This study aims to explore the effect of Exchange-protein activated by cAMP 1 (EPAC1) on AF in isoproterenol (ISO)-induced HF and the potential molecular mechanism. MATERIALS AND METHODS Mice and cultured isolated adult cardiomyocytes were treated with ISO and or not EPAC1 inhibitor CE3F4. Programmed electrical stimulation (PES) was performed to induce AF. EPAC1 expression was determined by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) and Western blot. Cellular electrophysiology was examined by whole cell patch clamp. RESULTS Both mRNA and protein levels of EPAC1 were upregulated in HF mice. ISO increased the AF susceptibility, and the negative effect was deteriorated by CE3F4. ISO mediated high AF susceptibility of HF via prolonging action potential and exciting L-type calcium channel (LTCC). These could also be reversed by CE3F4 treatment. CONCLUSIONS EPAC1 increased the AF susceptibility in ISO-induced HF mouse model via alternating LTCC.
Mate Choice versus Mate Preference: Inferences about Color-Assortative Mating Differ between Field and Lab Assays of Poison Frog Behavior

Codivergence of mating traits and mate preferences can lead to behavioral isolation among lineages in early stages of speciation. However, mate preferences limit gene flow only when expressed as mate choice, and numerous factors might be more important than preferences in nature. In the extremely color polytypic strawberry poison frog (Oophaga pumilio), female mate preferences have codiverged with color in most allopatric populations tested. Whether these lab-assayed preferences predict mating (gene flow) in the wild remains unclear. We observed courting pairs in a natural contact zone between red and blue lineages until oviposition or courtship termination. We found color-assortative mating in a disturbed habitat with high population density but not in a secondary forest with lower density. Our results suggest color-assortative O. pumilio mate choice in the wild but also mating patterns that do not match those predicted by lab-assayed preferences.
Propolis loaded liposomes: evaluation of antimicrobial and antioxidant activities

Abstract Propolis, a natural bee product, has both antimicrobial/antifungal and antioxidant characteristics. Active substances having antimicrobial and antifungal effects are used to avoid infections, which develop during long treatment process of chronic wounds. Antioxidant substances protect wound areas against the effect of free radicals and accelerate the healing process. For this purpose, propolis was used to develop topical liposome formulations for wound treatment. Characterization studies (particle size distribution, polydispersity index, Zeta Potential, morphology pH, loading capacity, encapsulation efficiency, in-vitro release behaviour) as well as stability studies were performed. Then in-vitro antioxidant (free radical scavenging capacity and trolox equivalent antioxidant capacity) and antimicrobial/antifungal activities of formulations have been evaluated. The particle size of formulations was found within the range of 300–750 nm depending on the concentration of lipid and water phase in the formulation. The Zeta Potential and pH values of optimum formulation were −23.0 ± 0.666 and 6.34, respectively. Loading capacity and encapsulation efficiency were 66.535 ± 2.705% and 57.321 ± 2.448%. At the end of 8 h, 48.16% of propolis was released and the formulations were found stable during 3 months at +4 °C. Drug loaded liposome formulations significantly scavenged the ABTS+ radical in a dose-dependent manner of propolis when compared with unloaded liposome formulations (p < 0.05). The minimum inhibitory concentration (MIC) values of liposomes ranged from 512 to 128 μg/mL for bacteria and 256 to 128 μg/mL for fungi. Overall results showed that effective and innovative alternative was developed for topical application in wound treatment with propolis loaded liposomal formulations having antioxidant and antimicrobial effects.
Feature selection for data integration with mixed multiview data

Data integration methods that analyze multiple sources of data simultaneously can often provide more holistic insights than can separate inquiries of each data source. Motivated by the advantages of data integration in the era of "big data", we investigate feature selection for high-dimensional multi-view data with mixed data types (e.g. continuous, binary, count-valued). This heterogeneity of multi-view data poses numerous challenges for existing feature selection methods. However, after critically examining these issues through empirical and theoretically-guided lenses, we develop a practical solution, the Block Randomized Adaptive Iterative Lasso (B-RAIL), which combines the strengths of the randomized Lasso, adaptive weighting schemes, and stability selection. B-RAIL serves as a versatile data integration method for sparse regression and graph selection, and we demonstrate the effectiveness of B-RAIL through extensive simulations and a case study to infer the ovarian cancer gene regulatory network. In this case study, B-RAIL successfully identifies well-known biomarkers associated with ovarian cancer and hints at novel candidates for future ovarian cancer research.
Frequency of ABO Blood Group and Rh (D) Negative Mothers Among Pregnant Women Attending at Antenatal Care Clinic of Sodo Health Center, SNNPR, Ethiopia

Background: - Women need to find out their blood type at the start of their pregnancy. Blood will be taken to find out, and there are four different types: A, B, AB, and O. In addition to blood type, women can have Rh factor (specifically Rhesus D antigen), which is when proteins appear on the surface of the blood. Women who do have Rh factors are classified as Rh positive (A+, B+, AB+, and O+), and women who don't are Rh negative (A-, B-, AB- and O). OBJECTIVE: Assessment of the frequency of ABO blood group and Rh (D) negative among pregnant women attending at antenatal care clinic of Sodo health center. METHOD: a retrospective study was conducted at the Sodo health center ANC clinic from Jan-April 2019. A total of 270 study participants was used. A systematic random sampling technique was used to select the study participants. Socio-demographic information was collected using pretested questionnaires. The data was edited, cleaned, entered, and analyzed by using SPSS 20. Statistical test between dependent and independent variables has been done by using multivariable logistic registration. Moreover, the table and different forms of the graph was used to present data. RESULT: Among a total of 270 study subjects, O comprised 41.1% ‘A’ (28.5%). ‘B’ and ‘AB’ accounts (24.5%) and (5.9%) respectively. Rh blood group results revealed that 7.0% of the participants were Rh-negative. CONCLUSION: This result showed that the most prevalent blood group is O while the least prevalent is the AB blood group. The frequency of Rh (D) negative pregnant women was 7.0%, among these blood group O Rh (D) negative was the most frequent. Generally, the frequency of Rh (D) negative pregnant women in this study is higher than most studies which were conducted elsewhere at different sites of the world which needs a great concern for appropriate prevention and management of Rhesus incompatibility during the antenatal visit of pregnant women.
Yet Another Tensor Toolbox for Discontinuous Galerkin Methods and Other Applications

The numerical solution of partial differential equations is at the heart of many grand challenges in supercomputing. Solvers based on high-order discontinuous Galerkin (DG) discretisation have been shown to scale on large supercomputers with excellent performance and efficiency if the implementation exploits all levels of parallelism and is tailored to the specific architecture. However, every year new supercomputers emerge and the list of hardware-specific considerations grows simultaneously with the list of desired features in a DG code. Thus, we believe that a sustainable DG code needs an abstraction layer to implement the numerical scheme in a suitable language. We explore the possibility to abstract the numerical scheme as small tensor operations, describe them in a domain-specific language (DSL) resembling the Einstein notation, and to map them to small General Matrix-Matrix Multiplication routines. The compiler for our DSL implements classic optimisations that are used for large tensor contractions, and we present novel optimisation techniques such as equivalent sparsity patterns and optimal index permutations for temporary tensors. Our application examples, which include the earthquake simulation software SeisSol, show that the generated kernels achieve over 50% peak performance of a recent 48-core Skylake system while the DSL considerably simplifies the implementation.
Models of positive Truth

This paper is a follow-up to "Models of PT${}^-$ with internal induction for total formulae. " We give a strenghtening of the main result on the semantical non-conservativity of the theory of PT${}^-$ with internal induction for total formulae (PT${}^- +$ INT(tot)). We show that if to PT${}^-$ the axiom of internal induction for all arithmetical formulae is added (PT${}^-$), then this theory is semantically stronger than PT${}^- +$ INT(tot). In particular the latter is not relatively truth definable (in the sense of Fujimoto) in the former. Last but not least we provide an axiomatic theory of truth which meets the requirements put forward by Fischer and Horsten in "The expressive power of truth. "
Radiometric consistency between GOES-16 ABI and VIIRS on Suomi NPP and NOAA-20

Abstract. NOAA has both geostationary (GEO) and polar orbiting (LEO) satellites that are procured through different vendors. For long-term environmental studies, it is essential to establish consistent radiometric calibration among satellite instruments irrespective of the satellite platforms. The Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-orbiting Partnership (S-NPP) and NOAA-20 satellites has been providing critical weather and climate-related data. With the launch of NOAA-20 in November 2017, the global coverage of VIIRS has doubled. With more than 7 years in space, S-NPP VIIRS has been rigorously calibrated and validated. We aim to quantify the radiometric consistency between the two VIIRS instruments through double differencing using GOES-16 Advanced Baseline Imager (ABI) as a reference instrument. We also provide insight into the temporal radiometric consistency between VIIRS and ABI. Since no direct simultaneous nadir overpasses (SNOs) exist between SNPP and NOAA-20 for intercomparison, GEO-LEO intercalibration is performed using SNOs between ABI and VIIRS instruments. We show that the NOAA-20 VIIRS measured top-of-atmosphere (TOA) reflectance is consistently lower than that of the S-NPP, mostly on the order of 2% to 3%, consistent with the past studies. GOES-16 ABI-observed reflectance is higher than both VIIRS instruments. SNOs over the all-sky tropical ocean are analyzed to quantify the bias for both NOAA-20 and S-NPP VIIRS relative to ABI. The impact on bias due to spectral differences is accounted for using spectral band adjustment factors estimated using hyperspectral measurements from SCIAMACHY. Uncertainties exist mainly due to calibration uncertainties in VIIRS and ABI, the time difference between the VIIRS and ABI observations, differences in cloud contamination, spectral response function differences, and lack of in-situ hyperspectral data to account for the spectral bias.