Miracle-dz/UniFAR-FTUs huggingface dataset:
Title: WDR82 mediated H3K4me3 is associated with tumor proliferation and therapeutic efficacy in pediatric high-grade gliomas mediated in pediatric H3K4me3 Levels Increase with histopathological malignancy in pediatric gliomas.

Pediatric high-grade gliomas (pHGGs) are common malignant brain tumors without effective treatment and poor patient survival. Abnormal posttranslational modification at the histone H3 tail plays critical roles in tumor cell malignancy. We have previously shown that trimethylation of lysine 4 at histone H3 (H3K4me3) plays a significant role in pediatric ependymoma malignancy and is associated with tumor therapeutic sensitivity. Here, we show that H3K4me3 and its methyltransferase WDR82 are elevated in pHGGs. Reduction of H3K4me3 by downregulating WDR82 decreases H3K4me3 promoter occupancy and expression of genes associated with stem cell features, cell proliferation, the cell cycle and DNA damage repair. Reduction of WDR82 mediated H3K4me3 increases the response of pediatric glioma cells to chemotherapy. These findings suggest that WDR82 mediated H3K4me3 is an important determinant of pediatric glioma malignancy and therapeutic response. This highlights the need for a more thorough understanding of the potential of WDR82 as an epigenetic target to increase therapeutic efficacy and improve prognosis for children with malignant gliomas. A set of three SMARTvector inducible lentiviral shRNA plasmids with hEF1 promoter and TurboGFP reporter against human WDR82 Gene
Modelling entrainment volume due to surface-parallel vortex interactions with an air–water interface

Abstract We consider the entrainment volume that results from the quasi-two-dimensional interactions of rising surface-parallel vorticity with an air–water interface. Based on systematic (three-dimensional) direct numerical simulations (DNS) of the canonical problem of a rectilinear vortex pair impinging on and entraining air at the free surface, we develop a phenomenological model to predict the resulting entrainment volume in terms of four key parameters. We identify a new parameter, a circulation flux Froude number $Fr^2_\Xi =|\varGamma |W/a^2\,g$, that predicts the dimensionless volume $\forall$ of entrained air initiated by a coherent vortical structure of circulation $\varGamma$, effective radius $a$, vertical rise velocity $W$ with gravity $g$. For $Fr^2_\Xi$ below some critical value $Fr^2_{\Xi cr}$, no air is entrained. For $Fr^2_\Xi >Fr^2_{\Xi cr}$, the average initial entrainment $\overline {\forall }_o$ scales linearly with ($Fr^2_\Xi -Fr^2_{\Xi cr}$). We also find that $\overline {\forall }_o$ is linearly dependent on circulation Weber number $We_{\varGamma }$ for a range of vortex Bond number $5 \lesssim Bo_{\varGamma } \lesssim 50$, and parabolically dependent on circulation Reynolds $Re_{\varGamma }$ for $Re_{\varGamma }\lesssim 2580$. Outside of these ranges, surface tension and viscosity have little effect on the initial entrainment volume. For the canonical rectilinear vortex problem, the simple model predicts $\overline {\forall }_o$ extremely well for individual coherent structures over broad ranges of $Fr^2_\Xi$, $We_{\varGamma }$, $Bo_{\varGamma }$ and $Re_{\varGamma }$. We evaluate the performance of this parameterisation and phenomenological entrainment model for air entrainment due to the complex periodic vortex shedding and quasi-steady wave breaking behind a fully submerged horizontal circular cylinder. For the range of parameters we consider, the phenomenological model predicts the event-by-event dimensionless entrainment volume measured in the DNS satisfactorily for this complex application.
Uncertainty in Games

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The global simulation of dissolved 231 Pa and 230 Th in the ocean and the sedimentary 231 Pa / 230 Th ratios by using an ocean general circulation model

Sedimentary 231Pa/230Th ratios provide clues to estimate the strength of past ocean circulation. For its estimation, understanding the processes controlling the distributions of 231Pa and 230Th in the ocean is important. However, simulations of dissolved and particulate 231Pa and 230Th in the modern ocean, recently obtained from the GEOTRACES project, remain 10 challenging. Here we report a model simulation of 231Pa and 230Th in the global ocean with COCO ver4.0. Starting from the basic water-column reversible scavenging model, we also introduced the bottom scavenging and the dependence of scavenging efficiency on particle concentration. As demonstrated in a previous study, the incorporation of bottom scavenging improves the simulated distribution of dissolved 231Pa and 230Th in the deep ocean, which has been overestimated in models not considering the bottom scavenging. We further demonstrate that introducing the dependence of scavenging efficiency on 15 particle concentration results in a high concentration of dissolved 230Th in the Southern Ocean as observed in the GEOTRACES data. Our best simulation can well reproduce not only the oceanic distribution of 231Pa and 230Th but also the sedimentary 231Pa/230Th ratios. Sensitivity analysis reveals that oceanic advection of 231Pa primarily determines sedimentary 231Pa/230Th ratios. On the other hand, 230Th advection and bottom scavenging have an opposite effect to 231Pa advection on the sedimentary 231Pa/230Th ratios, reducing their latitudinal contrast. Our best simulation shows the realistic residence times of 231Pa and 230Th, 20 but simulation without bottom scavenging and dependence of scavenging efficiency on particle concentration significantly overestimates the residence times for both 231Pa and 230Th in spite of similar distribution of sedimentary 231Pa/230Th ratios to our best simulation.
The Mereological Structure of Distributivity: A Case Study of Binominal Each

Binominal each is known to exhibit selectional requirements on the noun phrase that immediately precedes it. The goal of this paper is to reduce these selectional requirements to a single requirement of monotonic growth of measurement in relation to the ‘size’ of distributivity. More concretely, it is argued that binominal each imposes a constraint on the functional dependencies arising from distributive quantification, requiring that the measurement of its host grows monotonically with the number of values being distributively quantified. To make constraints on dependencies formally explicit, I devise a version of dynamic plural logic with features from van den Berg (1996) and Brasoveanu (2008, 2013) to semantically represent dependencies arising from evaluating distributive quantification. The use of a dynamic logic, coupled with a delayed evaluation mechanism in terms of higher order meaning (Cresti 1995, de Swart 2000, Charlow, to appear), allows the constraint to act as an output context constraint on distributive quantification, which mirrors the use of output constraints pioneered by Farkas (1997, 2002b) and and further developed in Brasoveanu (2013), Henderson (2014) and Kuhn (2017).
Point and Network Notions of Artificial Intelligence Agency

As intelligent machines are more and more present in our environment, the interest of researchers in the problem of AI (artificial intelligence) agency is growing significantly. In light of this, this paper aims to examine the dominant trends in AI agency research regarding their philosophical implications, as well as to provide a research commentary. Recurring themes of point and network notions of agency are identified, based on which the argument for the dual-process nature of agency perception is presented. Emphasis is placed on the agency attribution phenomenon. The novel hypothesis of a negative correlation between the perceived agency of AI and its interpretability outlines the future research direction.
Evaluating Rainy Weather Effects on Driving Behaviour Dimensions of Driving Behaviour Questionnaire

This study aims to develop a modified version of the existing driving behaviour questionnaire (DBQ) by including items related to driving behaviour under rainy conditions to evaluate driving behaviour changes and their implications. A survey of 680 drivers in Iran was conducted with the modified DBQ considering rainy conditions. Exploratory and confirmatory factor analysis concluded a four-factor solution (high velocity with a law violation, slips, positive and cautious behaviours, and aggressive driving behaviours) with a 52% explanation of variance. One of the most affected driving behaviours during rainfall is the tendency of high velocity with law violation behaviours. Compared to male drivers, female drivers showed lower high-velocity behaviours with law violation when driving in dry weather and in rainy weather. Married drivers have not only less tendency to drive fast or violate the law compared to single drivers but are also less susceptible to these actions during rain. It was observed that young drivers under 25 did not change their aggressive driving behaviours in rainy conditions. The results from this study are valuable resources to help transportation agencies to understand drivers’ likely behaviour in rainy conditions and develop appropriate countermeasures to minimize the risky behaviours. Also, since aggressive driving, high acceleration, and speed variance have been reported to result in high fuel consumption and emissions, the findings from this study are valuable resources to understand the relationship between weather, driver behaviour, and emissions in future studies.
Assessing Distinct Cognitive Workload Levels Associated with Unambiguous and Ambiguous Pronoun Resolutions in Human–Machine Interactions

Pronoun resolution plays an important role in language comprehension. However, little is known about its recruited cognitive mechanisms. Our investigation aims to explore the cognitive mechanisms underlying various types of pronoun resolution in Chinese using an electroencephalograph (EEG). We used three convolutional neural networks (CNNs)—LeNeT-5, GoogleNet, and EffifcientNet—to discover high-level feature abstractions of the EEG spatial topologies. The output of the three models was then fused using different scales by principal component analysis (PCA) to achieve cognitive workload classification. Overall, the workload classification rate by fusing three deep networks can be achieved at 55–63% in a participant-specific manner. We provide evidence that both the behavioral indicator of reaction time and the neural indicator of cognitive workload collected during pronoun resolution vary depending on the type of the pronoun. We observed an increase in reaction time accompanied by a decrease of the theta power while participants were processing ambiguous pronoun resolution compared to unambiguous controls. We propose that ambiguous pronoun resolution involves a more time-consuming yet more flexible cognitive mechanism, consistent with the predictions of the decision-making framework from an influential pragmatic tradition. Our results extend previous research that the cognitive states of resolving ambiguous and unambiguous pronouns are differentiated, indicating that cognitive workload evaluated using the method of machine learning for analysis of EEG signals acts as a complementary indicator for studying pronoun resolution and serves as an important inspiration for human–machine interaction.
MEDT: Using Multimodal Encoding-Decoding Network as in Transformer for Multimodal Sentiment Analysis

Multimodal sentiment analysis is a challenging task in the field of natural language processing (NLP). It uses multimodal signals (natural language, facial gestures, and acoustic behavior) in videos to generate emotional understanding. However, the importance of single modality data in the video to emotional outcomes is not static. With the extension of the time dimension, the emotional attributes of a specific natural language will be affected by non-natural language data, resulting in a vector shift in the feature space. At the same time, long-term dependencies within a specific modality and long-term dependencies between multiple modalities that are “unaligned” need to be considered. In response to the above problems, this paper proposes Multimodal Encoding-Decoding Network with Transformer. The network model encodes multimodal data through a Bidirectional Encoder Representations from Transformers (BERT) network and Transformer encoder to resolve long-term dependencies within modalities. And the network reconstructs the Transformer decoder to solve the weight problem of multimodal data in an iterative way. The network fully considers the long-term dependencies between modalities and the offset effect of non-natural language data on natural language data. Under the same experimental conditions, we validated our model on general multimodal sentiment analysis datasets. Compared with state-of-the-art models, the network achieves good progress and strong stability.
How Perceived Organizational Obstruction Influences Job Satisfaction: The Roles of Interactional Justice and Organizational Identification

In this study, the concept of perceived organizational obstruction was discussed and the results of the perception of obstruction were determined with reference to social exchange theory perspective. In this context, we tested a moderated mediation model that examines organizational identification as the mediator and interactional justice as the moderator in the relationship between perceived organizational obstruction and job satisfaction. Research data were obtained through the survey technique from 293 employees of a hospital in Turkey. In the findings of the analysis, it was observed that organizational identification has a mediating effect on the relationship between perceived organizational obstruction and job satisfaction. In addition, it was determined that interactional justice has a moderator effect on the relationship between perceived organizational obstruction and organizational identification. Furthermore, results supported the moderated mediation model and showed that the indirect effect of perceived organizational obstruction on job satisfaction through organizational identification was stronger under low interactional justice than under high interactional justice. Theoretical and practical implications are discussed.
Robotic Anxiety—Parents’ Perception of Robot-Assisted Pediatric Surgery

In contrast to many other countries, robot-assisted (RA) pediatric surgery is not yet very common in Germany. Although the first pediatric RA intervention was published in 2001, RA pediatric surgery is still perceived as a “new technology”. As a consequence, little is known about parents’ perception of this operation method. In this study, we analyzed parents‘ intention to let their child undergo RA and laparoscopic (LA) surgery. Two subsamples (online and at the University Medical Center Goettingen) received a questionnaire addressing attitude towards RA and LA pediatric surgery with the help of a case example. Results showed that parents had a higher intention to consent to LA surgery. Perceiving more benefits, assuming a positive attitude of the social environment, and feeling less anxiety increased intention. A mediation analysis indicated that the type of surgery affected intentions through assumed attitude of the social environment. Exploratory analyses showed that the perception of risks and anxiety reduced intention for only RA surgery. These findings should be considered in preoperational discussions with parents. Anxiety and perceived risks should especially be addressed in order to encounter hesitancy.
Prospective Application of Partially Digested Autologous Chondrocyte for Meniscus Tissue Engineering

Background: Meniscus tissue engineering has yet to achieve clinical application because it requires chondrogenic induction and in vitro cell expansion. Contrarily, cartilage engineering from autologous chondrocytes has been successfully applied in one-stage surgery. If the natural chondrogenic potential of meniscus cells can be demonstrated, meniscus tissue engineering would have more value in clinical settings. Materials and Methods: In total, 10 menisci and pieces of cartilage were obtained during total knee replacements. The tissues were collected for cell isolation and expansion. Their chondrogenic properties were examined by immunohistofluorescence and gene expression analyses. Results: In native cartilage, immunofluorescence demonstrated the presence of collagen I, aggrecan, and traces of collagen I, whereas comparable staining was seen in the inner and middle meniscus. The presence of collagen I but the absence of collagen II and aggrecan were observed in the outer meniscus. In passage 2, chondrocytes showed the presence of collagen II and aggrecan, and the absence of vimentin. The vimentin and aggrecan staining were comparable in the inner and middle meniscus cells, whereas the outer cells showed only vimentin staining. In the gene expression analyses, the expressions of collagen II and aggrecan in the native chondrocyte and the inner and middle meniscus were higher than those of the cells from the outer meniscus, but they were not different in collagen I. In the passage 2 culture, chondrocytes had a higher expression of collagen II and aggrecan than the meniscus cells. Cells from the inner and middle areas had higher collagen II and aggrecan expression than those from the outer meniscus. Conclusion: Without chondrogenic induction, inner and middle meniscus cells possess a chondrogenic phenotype. Specifically, native meniscus cells exhibited more robust chondrogenic potential compared with those of the passage 2 monolayer culture.
The Effectiveness of Repetition or Multiplicity of Different Surgical and Non-Surgical Procedures Compared to a Single Procedure Application in Accelerating Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis

In this study, we aimed to assess the current scientific evidence concerning the effectiveness of combining two acceleration techniques or repeating an acceleration procedure in comparison with the single application in terms of the speed of the orthodontic tooth movement (OTM). We performed a comprehensive electronic search to retrieve relevant studies on 10 databases. Randomized controlled trials (RCTs) on fixed orthodontic treatment patients who received multiple types of acceleration techniques or underwent a repeated acceleration procedure compared to a single application were included. Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used for assessing the risk of bias of retrieved studies. A total of six RCTs were included in this review. Regarding multiple acceleration methods, it seems that the combination of low-level laser therapy (LLLT) with a surgical technique outperforms the single application of each technique separately. Additionally, the combination of two surgical interventions may have a synergistic effect leading to reduced treatment time compared to the application of a single intervention. Regarding acceleration method repetition, it seems that the re-application of surgical procedures twice is more efficient than the single application. The meta-analysis showed a non-significant difference in the canine retraction rate between the four-weekly micro-osteoperforations (MOPs) (three times of applications) and both the eight-weekly MOPs (two times of applications) [mean difference (MD) = 0.24; 95% CI: -0.2-0.77; p = 0.36], as well as 12-weekly MOPs (two times of applications) (MD = 0.06; 95% CI: -0.14-0.27; p = 0.55). Based on very low evidence, combining two acceleration techniques is superior over a single application in accelerating tooth movement. Again, very low evidence suggests that the efficacy of repetition of surgical procedures twice and three times is similar. Further high-quality RCTs are required to assess the benefit of repeating an acceleration procedure or combining two different methods. In addition, more insight is needed into the possible side effects associated with the repetition or multiplicity of procedures.
Influence of exogenous corticosterone on testicular function and mating behavior of Nigerian indigenous cocks

Abstract In bridging the knowledge gap on stress physiology of Nigerian indigenous chickens, this study investigated the effect of exogenous corticosterone (eCORT) as stress inducing agent on the testicular function and mating behavior of Nigerian indigenous cocks. Twenty-four (24) cocks and one hundred and forty four (144) hens (mating ratio of 1 cock: 6 hens) were grouped into four and assigned to each of the four eCORT treatments (0, 2, 4 and 6 mgeCORT/KgBW) daily for 14 days. Semen samples were collected on days 0, 7 and 14 and analyzed for semen volume (SV), progressive sperm motility (PSM), membrane integrity (MI) and sperm abnormality (SA). Mating behaviors were monitored on days 3, 5 and 8. Blood samples, for hormonal (Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) Testosterone (TEST) and stress analysis (heterophil/lymphocyte ratio, H/L) were collected from brachial vein on days 7 and 14. On day 15, cocks were euthanized and testes harvested for histomorphometry. Data were analyzed using multivariate analysis, one–way ANOVA and Kruskal-Wallis tests all in SPSS 23. Administration of 4 mgeCORT/KgBW declined (P<0.05) PSM while 4 mgeCORT/KgBW and 6 mgeCORT/KgBW cocks had reduced (P<0.05) SV and MI with increased SA. Compared to baseline values, progressive sperm motility of cocks administered 6 mgeCORT for 7 and 14 days decreased (P<0.05) by 57.5% and 52.4%, respectively. Exogenous CORT had no significant (P>0.05) influence on the mating behaviors, H/L ratio, FSH and TEST. However, 2 mgeCORT/KgBW enhanced LH levels. Administration of eCORT did not affect the testicular epithelial height and seminiferous tubular diameter. In conclusion, optimal stress induced by eCORT impaired semen quality but with less impact on reproductive hormones, H/L and mating behaviors of intensively raised Nigerian indigenous cocks.
Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition

Abstract Milk fats are present as globules emulsified in the aqueous phase of milk and stabilized by a delicate membrane architecture called milk fat globule membrane (MFGM). The unique structure and composition of the MFGM play an important role in fat digestion and the metabolic programming of neonates. The objective of this review is to compare the structure, composition, and physicochemical characteristics of fat globules in human milk, bovine milk, and infant formula. It provides an overview of the fat digestion process and enzymes in healthy infants, and describes the possible roles of the MFGM in association with factors affecting fat digestion. Lastly, the health benefits of the MFGM on infant nutrition and future perspectives are discussed with a focus on brain development, metabolic response, and gut health.