Miracle-dz/UniFAR-FTUs huggingface dataset:
Daily Life Experiences: Challenges, Strategies, and Implications for Therapy in Postural Tachycardia Syndrome (POTS)

Abstract Postural tachycardia syndrome (POTS) is a condition of orthostatic intolerance which often leads to significant functional deficits. This study explores narrative responses from a large cohort (n = 958) of individuals with POTS in describing daily life challenges and the use of strategies to manage these difficulties. Data was coded and emergent themes provided insight into daily life experiences including successful interventions and a wealth of gaps in treatment that remain unaddressed. This led to the development of clinical recommendations for occupational therapy treatment of individuals with POTS. Further research is indicated including clinical trials to demonstrate the efficacy of occupational therapy intervention.
Selective Laser Sintering versus Selective Laser Melting and Computer Aided Design - Computer Aided Manufacturing in Double Crowns Retention.

PURPOSE This in vitro study aimed at ascertaining the retention forces for telescopic crowns fabricated with Selective Laser Manufacturing (SLM) and Selective Laser Sintering (SLS) additive technologies, and Computer Aided Design - Computer Aided Manufacturing (CAD-CAM) subtractive technology, by using suitable materials for each. MATERIALS AND METHODS Full-factorial design was employed for experimental testing, considering the following three factors: (a) inner crown material ‒ technology (zirconia ‒ CAD-CAM; metal-alloy ‒ SLS; metal-alloy ‒ SLM); (b) tooth type (canine or molar); (c) wet vs. dry conditions (i.e. either with or without artificial saliva). The roughness of the inner crowns was analyzed through atomic force microscopy. Three-way analysis of variance (ANOVA) was applied for statistical analysis, followed by Tukey's post-hoc comparisons between the crown types. RESULTS The retention force mean values were between 3.8 N (dry, SLM) and 14.8 N (artificial saliva, SLS), with statistically significant (p<0.001) differences between the three types of inner crowns and interaction with the tooth type. No significant interaction was found between crown or tooth types and the wet vs. dry testing conditions. The zirconia crowns' retention force was significantly (p<0.001) higher compared to similar SLM crowns, with 95% CI (3.62; 5.55) N for the differences. Zirconia was sig nificantly (p<0.001) less retentive compared to similar SLS crow ns, with 95% CI (-5.99; -4.06) N for the differences. The roughness decrease and subsequent loss of retention force was the largest in zirconia. CONCLUSIONS The SLS inner crowns showed the best retention, followed by zirconia and SLM inner crows.
Genetic Variability and Performance Studies of Tomato (Solanum lycopersicum L.) Genotypes for Fruit Quality and Yield

Agenetic parameters like range, mean, phenotypic coefficient of variation (PCV) and genotypic coefficient of variation (GCV), heritability, genetic advance as percent of mean was studied in tomato genotypes. All the characters studied revealed high PCV than GVC which indicates that there is less influence of environment on alteration of these characters. The high heritability has been observed for the plant height, number of flowers per truss, number of flower trusses per plant, fruit length, fruit diameter, fruit shape index, pericarp thickness, total soluble solids, average fruit weight, fruit firmness, number of fruits per plant and yield per plant. Hence, these character could be improved by simple selection. The genotypes EC-608406 BRML, IIHR-709, Arka Ashish, Vybhav, IIHR2388, EC-608395, IIVR-L, CLN 2123A and EC-608456 2 were the top ten high yield genotypes with respect to fruit quality and fruit yieldper plant based on mean performance intomato.
Investigated of ampC in Carbapenem Resistant Gram-Negative Bacteria Isolated from Burned Patients

Background : Gram-Negative bacteria are the most cause of nosocomial infection especially in burned patients. Carbapenem resistant strains can limit seriously the choice of antibiotic therapy. AmpC can make resistance to carbapenem and detection of that can be useful for identification of carbapenem resistant. The aim of this study was identification of ampC in most prevalent cause of nosocomial infection. Methods : boronic acid combined with meropenem in combination disc method was used for phenotypic method and PCR was used for molecular identification of ampC. Results : Fifty one strains showed positive results in phenotypic method but 119 strains were harbored ampC gene. Combination disc method with meropenem and boronic acid showed 34.4% sensitivity and 78.5% specificity according to the results of this study. Conclusions : the results of this study were indicated the more prevalent of ampC in carbapenem resistant Gram-Negative bacteria. On the other hand use of boronic acid combined with meropenem showed low sensitivity for detection of ampC.
Factors Restricting the Range of Glyptotendipes paripes Edwards (Diptera: Chironomidae) in a Bog Lake

Glyptotendipes paripes Edwards, a midge that often occurs in sufficiently high densities to be a nuisance during emergence periods, has (perhaps largely for this reason) attracted an unusual amount of attention. Accounts, concerned largely with control measures, include the work of Nielsen (1962), Patterson (1964), von Windeguth (1964) and Crossman (1966). From this work it is clear that G. paripes often occurs in lakes with a peaty bottom. There are also indications that within the lake mud distribution of the larvae may be influenced by substrate particle size (Provost & Branch 1959) as is often the case in freshwater lakes and streams (Cummins & Lauff 1969; McLachlan 1969). In some cases, at least, G.paripes larvae prefer the larger substrate particles (Marks & Henderson 1970). A small humic lake on Sphagnum moor in England provided a field situation which appeared to be particularly suitable for the study of factors influencing the distribution of mud-dwelling animals. Some of the important characteristics of this lake, including aspects of the distribution of Glyptotendipes paripes and other benthic insect larvae, are considered by McLachlan & McLachlan (1975). They demonstrated that a strong correlation exists between the number of G. paripes larvae and the proportion of coarse fragments in the sediment layer (illustrated in Fig. l(A),a). This correlation results in the fauna being restricted to one shore of the lake (Fig. 1(B)) where particle size sorting has deposited the heavier (larger) fragments following their erosion from the exposed coast. This distribution is striking in view of the small size of the lake (about 0-5 km2), its relatively uniform water depth (about 1 m throughout) and the fact that the lake bottom is composed entirely of peat (Fig 1(A),b). In order to investigate further this relationship between G. paripes and the substrate, a more detailed mud sampling programme was carried out within the area occupied by the larvae. This work was coupled with complementary field and laboratory experiments designed to reveal causal relationships between factors in the environment and the chironomid population.
Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence Survey Among 17 971 Healthcare and Administrative Personnel at Hospitals, Prehospital Services, and Specialist Practitioners in the Central Denmark Region

Abstract Background The objective of this study was to perform a seroprevalence survey on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among Danish healthcare workers to identify high-risk groups. Methods All healthcare workers and administrative personnel at the 7 hospitals, prehospital services, and specialist practitioner clinics in the Central Denmark Region were invited to be tested by a commercial SARS-CoV-2 total antibody enzyme-linked immunosorbent assay (Wantai Biological Pharmacy Enterprise Co, Ltd, Beijing, China). Results A total of 25 950 participants were invited. Of these, 17 971 had samples available for SARS-CoV-2 antibody testing. After adjustment for assay sensitivity and specificity, the overall seroprevalence was 3.4% (95% confidence interval [CI], 2.5%–3.8%). The seroprevalence was higher in the western part of the region than in the eastern part (11.9% vs 1.2%; difference: 10.7 percentage points [95% CI, 9.5–12.2]). In the high-prevalence area, the emergency departments had the highest seroprevalence (29.7%), whereas departments without patients or with limited patient contact had the lowest seroprevalence (2.2%). Among the total 668 seropositive participants, 433 (64.8%) had previously been tested for SARS-CoV-2 RNA, and 50.0% had a positive reverse-transcription polymerase chain reaction (PCR) result. Conclusions We found large differences in the prevalence of SARS-CoV-2 antibodies in staff working in the healthcare sector within a small geographical area of Denmark. Half of all seropositive staff had been tested positive by PCR prior to this survey. This study raises awareness of precautions that should be taken to avoid in-hospital transmission. Regular testing of healthcare workers for SARS-CoV-2 should be considered to identify areas with increased transmission.
ANÁLISE SENSORIAL DO SUCO INTEGRAL DE UVA ‘ISABEL’ SUBMETIDA À APLICAÇÃO DE ÁCIDO ABSCÍSICO

O suco de uva ‘Isabel’ apresenta deficiencia de cor e uma alternativa e o uso de acido abscisico para aumentar a coloracao. O objetivo deste trabalho foi avaliar a aceitacao do suco integral de uva ‘Isabel’ tratada com acido abscisico (S-ABA) em diferentes concentracoes e epocas, por meio da analise sensorial, obtido em duas safras consecutivas (2011 e 2012). O delineamento experimental utilizado foi em blocos completos casualizados, com quatro repeticoes e cinco tratamentos: Testemunha; S-ABA 200 mg L-1aplicado sete dias apos o inicio da maturacao (DAIM); S-ABA 400 mg L-1 aplicado aos sete DAIM; S-ABA 200 mg L-1 aplicado aos sete DAIM + 200 mg L-1 aplicado aos 15 dias apos a primeira aplicacao (DAPA); e S-ABA 400 mg L-1 aplicado aos sete DAIM + 400 mg L-1, aplicado aos 15 DAPA. Os sucos integrais dos tratamentos foram obtidos pelo processo ‘Welch’, em panela extratora por arraste de vapor. Para a avaliacao sensorial, contou-se com 70 julgadores nao treinados, que avaliaram os atributos: coloracao, aroma, sabor, corpo e aceitacao global, empregando-se uma escala hedonica de nove pontos. Verificou-se que todos os sucos integrais de uva ‘Isabel’ tratada com S-ABA apresentaram maior aceitacao pelos julgadores quanto aos atributos sensoriais avaliados, sendo a concentracao de 400 mg L-1 em uma unica aplicacao, aos sete DAIM, suficiente para propiciar esses resultados.
A note on the thyroid function of the pregnant females in the USA: data from NHANES 1999–2002 and 2007–2012

Thyroid dysfunction during pregnancy has been shown to be associated with adverse pregnancy outcomes. Consequently, this study was undertaken to assess the thyroid health of the pregnant females in the United States. Publically available data from National Health and Nutrition Examination Survey for the cycles 1999–2002 and 2007–2012 were analyzed for this purpose. Over 22% (SE: 5.7%) of the pregnant females based on the unweighted data in their first trimester had higher than the recommended levels of thyroid-stimulating hormone (TSH) or 2.5 mIU/L. Free triiodothyronine (FT3) and free thyroxine (FT4) levels decreased over pregnancy trimesters. Based on unweighted data, about 6% (SE: 2.6%) pregnant females were positive for thyroglobulin antibodies and 34.9% (SE: 5.2%) pregnant females were positive for thyroid peroxidase antibodies. Over 55% (SE: 3.5%) pregnant females based on the unweighted data were iodine deficient. As many as 41% (SE: 3%) first trimester pregnant females having TSH > 2.5 mIU/L is of concern. Future research should concentrate on developing educational and other materials that can advise pregnant females during their prenatal care and other appointments about the adverse effects of high TSH levels and what they can do to keep their TSH levels within the recommended levels.
Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

ABSTRACT Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections. Our previous study reported that gastric subserous layer (GSL) vaccination induced a “pool” of protective tissue-resident memory CD4+T (CD4+TRM) cells in the gastric epithelium. However, the mechanistic details how CD4+TRM cells form in the gastric epithelium are unknown. Here, our results suggested that the vaccine containing CCF in combination with Silk fibroin hydrogel (SF) broadened the distribution of gastric intraepithelial CD4+TRM cells. It was revealed that the gastric intraepithelial TRM cells were even more important than circulating memory T cells against infection by Helicobacter felis. It was also shown that gastric-infiltrating neutrophils were involved as indispensable mediators which secreted CXCL10 to chemoattract CXCR3+CD4+T cells into the gastric epithelium. Blocking of CXCR3 or neutrophils significantly decreased the number of gastric intraepithelial CD4+TRM cells due to reduced recruitment of CD4+T cells. This study demonstrated the protective efficacy of gastric CD4+TRM cells against H. felis infection, and highlighted the influence of neutrophils on gastric intraepithelial CD4+TRM cells formation.
The Effect of Dose Escalation on the Cost-Effectiveness of Etanercept and Adalimumab with Methotrexate Among Patients with Moderate to Severe Rheumatoid Arthritis

BACKGROUND: Patients with moderate to severe rheumatoid arthritis (RA) occasionally increase their doses of tumor necrosis factor (TNF) inhibitors, especially the monoclonal antibody origin drugs such as adalimumab and infliximab, after inadequate response to the initial dose. Previous studies have evaluated the cost-effectiveness of various sequences of treatment for RA in the United States but have not considered the effect of dose escalation. OBJECTIVE: To assess the cost-effectiveness of etanercept and adalimumab by incorporating the effect of dose escalation in moderate to severe RA patients. METHODS: We adapted the open-source Innovation and Value Initiative – Rheumatoid Arthritis model, version 1.0 to separately simulate the magnitude and time to dose escalation among RA patients taking adalimumab plus methotrexate or etanercept plus methotrexate from a societal perspective and lifetime horizon. An important assumption in the model was that dose escalation would increase treatment costs through its effect on the number of doses but would have no effect on effectiveness. We estimated the dose escalation parameters using the IBM MarketScan Commercial and Medicare Supplemental Databases. We fit competing parametric survival models to model time to dose escalation and used model diagnostics to compare the fit of the competing models. We measured the magnitude of dose escalation as the percentage increase in the number of doses conditional on dose escalation. Finally, we used the parameterized model to simulate treatment sequences beginning with a TNF inhibitor (adalimumab, etanercept) followed by nonbiologic treatment. RESULTS: In baseline models without dose escalation, the incremental cost per quality-adjusted life-year of the etanercept treatment sequence relative to the adalimumab treatment sequence was $85,593. Incorporating dose escalation increased treatment costs for each sequence, but costs increased more with adalimumab, lowering the incremental cost-effectiveness ratio to $9,001. At willingness-to-pay levels of $100,000, the etanercept sequence was more cost-effective compared with the adalimumab sequence, with probability 0.55 and 0.85 in models with and without dose escalation, respectively. CONCLUSIONS: Dose escalation has important effects on cost-effectiveness and should be considered when comparing biologic medications for the treatment of RA.
On the search for the right definition of heart failure with preserved ejection fraction.

The definition of heart failure with preserved ejection fraction (HFpEF) has evolved from a clinically based "diagnosis of exclusion" to definitions focused on objective evidence of diastolic dysfunction and/or elevated left ventricular filling pressures. Despite advances in our understanding of HFpEF pathophysiology and the development of more sophisticated imaging modalities, the diagnosis of HFpEF remains challenging, especially in the chronic setting, given that symptoms are provoked by exertion and diagnostic evaluation is largely conducted at rest. Invasive hemodynamic study, and in particular - invasive exercise testing, is considered the reference method for HFpEF diagnosis. However, its use is limited as opposed to the high number of patients with suspected HFpEF. Thus, diagnostic criteria for HFpEF should be principally based on non-invasive measurements. Because no single non-invasive variable can adequately corroborate or refute the diagnosis, different combinations of clinical, echocardiographic, and/or biochemical parameters have been introduced. Recent years have brought an abundance of HFpEF definitions. Here, we present and compare four of them: 1) the 2016 European Society of Cardiology (ESC) criteria for HFpEF; 2) the 2016 echocardiographic algorithm for diagnosing diastolic dysfunction; 3) the 2018 evidence-based H₂FPEF score; and 4) the most recent, 2019 Heart Failure Association HFA-PEFF algorithm. These definitions vary in their approach to diagnosis, as well as sensitivity and specificity. Further studies to validate and compare the diagnostic accuracy of HFpEF definitions are warranted. Nevertheless, it seems that the best HFpEF definition would originate from a randomized clinical trial showing a favorable effect of an intervention on prognosis in HFpEF.
Long‐term effectiveness of dupilumab up to 52 weeks in atopic dermatitis in 253 adult patients

Dupilumab, an inhibitor of interleukin (IL)-4/13 activity, is a biological agent approved for the treatment of moderate-to-severe atopic dermatitis (AD)1 . Our aim was to assess the long-term effectiveness and safety of dupilumab in a clinical real-life setting.
Acute and late neurological complications of COVID19: the quest for evidence

1 Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China 2 NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK 3 Chalfont Centre for Epilepsy, Chalfont St Peter SL9 0RJ, UK 4 Department of Neuroscience, Central Clinical School, Monash University, Alfred Hospital, Melbourne, Parkville, Victoria, Australia 5 Departments of Medicine and Neurology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia 6 Department of Neuroscience, NEUROMOVE Rehab Lab, and Padova Neuroscience Center, University of Padova, Italy 7 Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands
β-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults: a randomized controlled trial

The number of elderly individuals with age-related cognitive decline or dementia is rapidly increasing. Dairy product consumption, including β-lactolin, is beneficial for their cognitive function. The underlying mechanism of β-lactolin’s effects on human brain activity is yet to be investigated. We examined the β-lactolin effects on human cerebral blood flow (CBF) using near-infrared spectroscopy (NIRS) in a placebo-controlled randomized double-blind study, which reported according to the CONSORT guidelines. Fifty healthy participants (aged 45–60 years) were randomly allocated into the β-lactolin or the placebo group (n = 25 each) and supplemented for 6 weeks. During the 6th week, oxy-hemoglobin during the working memory tasks was measured using 34-channels (CHs) NIRS. The changes of oxy-hemoglobin, which represents the CBF, in CH 23 located at the left dorsolateral prefrontal cortex (DLPFC) during the spatial working memory task showed higher statistical significance (false discovery rate (q) = 0.045) in the β-lactolin than in the placebo group. The oxy-Hb changes in CH23 have a co-relationship with the working memory task reaction time. This clinical trial showed an increase in the CBF in the left DLPFC area during the 6-week β-lactolin supplementation. This study contributes to elucidating the underlying mechanisms of β-lactolin on cognitive performance.
Inter-rater reliability of paediatric emergency assessment: physiological and clinical features

Objective The Paediatric Admission Guidance in the Emergency Department (PAGE) score is an assessment tool currently in development that helps predict hospital admission using components including patient characteristics, vital signs (heart rate, temperature, respiratory rate and oxygen saturation) and clinical features (eg, breathing, behaviour and nurse judgement). It aims to assist in safe admission and discharge decision making in environments such as emergency departments and urgent care centres. Determining the inter-rater reliability of scoring tools such as PAGE can be difficult. The aim of this study was to determine the inter-rater reliability of seven clinical components of the PAGE Score. Design Inter-rater reliability was measured by each patient having their clinical components recorded by two separate raters in succession. The first rater was the assessing nurse, and the second rater was a research nurse. Setting Two emergency departments and one urgent care centre in the North West of England. Measurements were recorded over 1 week; data were collected for half a day at each of the three sites. Patients A convenience sample of 90 paediatric attendees (aged 0–16 years), 30 from each of the three sites. Main outcome measures Two independent measures for each child were compared using kappa or prevalence-adjusted bias-adjusted kappa (PABAK). Bland-Altman plots were also constructed for continuous measurements. Results Inter-rater reliability ranged from moderate (0.62 (95% CI 0.48 to 0.74) weighted kappa) to very good (0.98 (95% CI 95 to 0.99) weighted kappa) for all measurements except ‘nurse judgement’ for which agreement was fair (0.30, 95% CI 0.09 to 0.50 PABAK). Complete information from both raters on all the clinical components of the PAGE score were available for 73 children (81%). These total scores showed good’ inter-rater reliability (0.64 (95% CI 0.53 to 0.74) weighted kappa). Conclusions Our findings suggest different nurses would demonstrate good inter-rater reliability when collecting acute assessments needed for the PAGE score, reinforcing the applicability of the tool. The importance of determining reliability in scoring systems is highlighted and a suitable methodology was presented. This study assesses the inter-rater reliability of the Paediatric Admission Guidance in the Emergency Department (PAGE) score. The PAGE score is an assessment tool currently in development that helps predict hospital admission using components including patient characteristics, vital signs and clinical features, to assist in safe admission and discharge. The authors found good inter-rater reliability among a group of nurses using the tool.