Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome

There are many metabolic and hormonal factors related to polycystic ovary syndrome (PCOS) that can be affected by vitamin D3 supplementation. To find clinical trials, in vivo studies, and in vitro studies that met the review's inclusion and exclusion criteria, we searched many databases. PCOS women's ovulation and metabolic parameters were examined in relation to the effects of vitamin D3 treatment on PCOS risk variables such as seasonal changes in body mass index, and obesity. The current review included twenty-five articles. Vitamin D3(25-hydroxy vitamin D) levels were significantly lower in the PCOS group than in the control group, and lipid profile and androgen hormone levels were significantly higher in the PCOS group, resulting in increased cardiovascular events and exaggerated hirsutism. According to the majority of research, vitamin D3 plays a beneficial role in decreasing the pathophysiology of PCOS, notably in restoring ovulation, which ultimately improves fertility. Although other studies found no effect on lipid profile, there was a minor effect on reducing cardiovascular risks. The response of patients to vitamin D3 was influenced by the dose administered and the study's methodology. In conclusion, vitamin D3 had a good effect on the pathophysiology of PCOS in the majority of investigations.
Presidential address: Adoption of a clinical skills examination for dental licensing, implementation of computer-based testing for the medical licensing examination, and the 30th anniversary of the Korea Health Personnel Licensing Examination Institute

vomiting, sarcopenia/paresthesia, mood change, memory loss, cough, breaking the bad news, palpitations, headache, tremor/dyskinesia, neck/back pain, substance misuse, fever, dysuria, abnormal bowel movements (constipation/diar-rhea), abdominal colic, anxiety, hematuria, prenatal examination, delayed growth/development, changes in urine output (polyuria/ oliguria), indigestion, sleep disorder, bruising that easily occurs, faint, dizziness, vaccination, dysmenorrhea/menorrhagia, breast pain/breast lumps (bulges), alcohol/smoking counseling, con-sciousness disorder, dyslipidemia, intentional self-harm, vaginal
Treadmill workouts alleviate neuropathic allodynia and scratching behavior in rats following thoracotomy

ABSTRACT Background The aim of the experiment was to investigate the effects of treadmill exercise on postthoracotomy pain and the expression of spinal pro-inflammatory and anti-inflammatory cytokines. Methods Animals were randomly distributed into four groups: (a) sham surgery, (b) rats following 60 min thoracotomy and rib retraction (thoracotomy), (c) thoracotomy rats received treadmill training (thoracotomy+treadmill), and (d) sham surgery rats received treadmill training (sham surgery+treadmill). Treadmill workouts were started on postoperative day 10 (POD10) and lasted for 6 weeks (5 days per week). Rats were examined for cold allodynia using acetone and mechanical allodynia using von Frey hairs (in grams) at the surgical site. Spinal pro-inflammatory and anti-inflammatory cytokines were analyzed on PODs 28 and 49. Results Both thoracotomy and thoracotomy+treadmill groups exhibited a decrease in mechanical force thresholds (g) and an increase in scratches per min on POD10. Mechanical hypersensitivity and incremental scratches lasted from POD14 and POD49 in the thoracotomy group. Although force thresholds and scratches remained not return to baseline, incremental force thresholds (p < 0.001) and diminutive scratches (p < 0.001) occurred after 6-week treadmill workouts. The rise in spinal interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) concentrations or the decline in spinal IL-10 concentration in thoracotomy+treadmill rats was less (p < 0.05) than thoracotomy rats without exercise. Conclusions Mechanical allodynia using von Frey filament testing and cold allodynia by acetone testing were improved in thoracotomy rats after treadmill workouts. Treadmill exercise restrained excess pro-inflammatory cytokine expression but increased anti-inflammatory cytokine level in a rib retraction model.
Pandemic-Triggered Online Teaching in Romania. A Language Teacher’s Perspective

Abstract With the restrictions caused by the pandemic, schools closed and classes went online in the spring of 2020. Suddenly, teachers found themselves in unexpected situations they had to deal with. With limited IT skills and no training courses offered by the Ministry of Education guiding them into the world of Google Classroom, Meet, or Zoom, teachers all over Romania had to cope with e-learning somehow. In the present study, I propose to investigate some of the positive and negative aspects of going online, to compare digital language classes involving different age groups (pupils of elementary schools or middle schools vs university students), as well as the diverse social background which influenced online learning to a large extent. I also intend to look at teaching different language skills: is there any relevant change in this respect as opposed to teaching face-to-face?
Exploration of Spa Leisure Consumption Sentiment towards Different Holidays and Different Cities through Online Reviews: Implications for Customer Segmentation

With the improvements in per capita disposable income, and an increase in work-related pressure, demand for leisure consumption such as foot bath spas is constantly increasing. Analysis of leisure consumption sentiment is of great importance for the leisure service industry—to meet customer needs, improve service quality and improve customer relationship management. However, traditional sentiment analysis approaches only aimed to ascertain the overall sentiment of the customer, which is less effective for analyzing customer satisfaction on account of customer size, different customer locations, and different leisure holidays. Sentiment analysis via online reviews can assist different businesses, including foot bath spa services, to better inform the development of customer segmentation strategies and ensure optimal customer relationship management. Hence, the objective of this paper is to explore foot bath spa leisure consumption sentiment towards different holidays and different cities by applying data mining via online reviews, so as to help optimize customer segmentation. A novel general framework and related sentiment analysis methods were proposed and then conducted through a collection of datasets from customers’ textual reviews of foot bath spa merchants in three cities in China on the Meituan social media platform. Findings confirm that the proposed general framework and methods can be used to gain insights into the swing characteristics of sentiment towards different holidays and different cities, to better develop customer segmentation according to the city-holiday emoticon face patterns obtained through sentiment tendency analysis from online social media review data. The study results can help to develop better customer and marketing strategies, thereby creating sustainable competitive advantages, and can be extended to other fields to support sustainable development.
Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence

We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients. Furthermore, sex differences in adherence for spironolactone and other antihypertensive drugs (AHDs) were studied. The patients in this post hoc study had all participated in a single-blind randomized controlled trial called RHYME-RCT (Dutch Trial Register, NL6736). Concentrations in blood of several AHDs were assessed in RHYME-RCT to investigate adherence to treatment. This allowed for a comparison of drug exposure to spironolactone and canrenone between males and females. In linear regression models, no statistically significant sex differences (N = 35) in spironolactone (B =−10.23, SE = 7.92, p = 0.206) or canrenone (B = 1.24, SE = 10.96, p = 0.911) concentrations after adjustment for dose and time between sampling and intake were found. Furthermore, no statistically significant differences in non-adherence to spironolactone were found between sexes (N = 54, male 15% vs. female 38%, p = 0.100), but non-adherence to spironolactone was associated with non-adherence to other AHDs (p ≤ 0.001). Spironolactone and canrenone concentrations were not different between males and females with resistant hypertension. Although not statistically significant, females were twice as likely to be non-adherent to spironolactone compared to males, and thereby also more likely to be non-adherent to other AHDs.
Corruption – Poverty Nexus: Evidence from Panel ARDL Approach for SAARC Countries

The article intends to investigate the relationship between corruption and poverty based on the panel data of SAARC countries over the period 1996–2019. We employed the panel ARDL of pooled mean group (PMG) technique to analyze the data and focus on capability poverty, using the human development index (HDI) as a proxy for poverty. The empirical findings of PMG of the ARDL model suggest that an increase in corruption score (COC) (i.e. decrease in corruption) and increase in women’s labor force participation rate (WLFPR) seem to have a significant impact either in eradicating poverty or increasing social welfare in the long run as well as in the short run. A random effect (RE) model also identified a significant positive relationship between corruption score and HDI, and WLFPR and HDI. A Dumitrescu-Hurlin pairwise panel Granger non-causality test detected a bilateral causality relationship between COC and HDI, and WLFPR and HDI, while unilateral causality ran from WLFPR to COC. The article contributes to examining the dynamics between corruption and poverty from the governance aspect, taking South Asia as a case study.
Projections of hydrofluorocarbon (HFC) emissions and the resulting global warming based on recent trends in observed abundances and current policies

Abstract. The emissions of hydrofluorocarbons (HFCs) have increased significantly in the past two decades, primarily as a result of the phaseout of ozone depleting substances under the Montreal Protocol and the use of HFCs as their replacements. Projections from 2015 showed large increases in HFC use and emissions in this century in the absence of regulations, contributing up to 0.5 °C to global surface warming by 2100. In 2019, the Kigali Amendment to the Montreal Protocol came into force with the goal of limiting the use of HFCs globally, and currently, regulations to limit the use of HFCs are in effect in several countries. Here, we analyze trends in HFC emissions inferred from observations of atmospheric abundances and compare them with previous projections. Total CO2-eq inferred HFC emissions continue to increase through 2019 (to about 0.8 GtCO2-eq yr−1) but are about 20 % lower than previously projected for 2017–2019, mainly because of lower global emissions of HFC-143a. This indicates that HFCs are used much less in industrial and commercial refrigeration (ICR) applications than previously projected. This is supported by data reported by the developed countries and lower reported consumption of HFC-143a in China. Because this time-period preceded the beginning of the Kigali controls, this reduction cannot be linked directly to the provisions of the Kigali Amendment. However, it could indicate that companies transitioned away from the HFC-143a with its high global warming potential (GWP) for ICR applications, in anticipation of national or global mandates. A new HFC scenario is developed based on current trends in HFC use and current policies in several countries. These current policies reduce projected emissions in 2050 from the previously calculated 4.0–5.3 GtCO2-eq yr−1 to 1.9–3.6 GtCO2-eq yr−1. The provisions of the Kigali Amendment are projected to reduce the emissions further to 0.9–1.0 GtCO2-eq yr−1 in 2050. Without current policies, HFCs would be projected to contribute 0.28–0.44 °C to the global surface warming in 2100, compared to 0.14–0.31 °C with current policies, but without the Kigali Amendment. In contrast, the Kigali Amendment controls are expected to limit surface warming from HFCs to about 0.04 °C in 2100.
Statistical Validation of Cardiovascular Digital Biomarkers Towards Monitoring the Cardiac Risk in COPD: A Lyfas Case Study

Background: Mobile health (mHealth) is gaining popularity due to its pervasiveness. Lyfas is a smartphone-based optical biomarker instrument catering to mHealth. It captures the Pulse Rate Variability (PRV) and its associated digital biomarkers from the index finger capillary circulation using the principle of arterial photoplethysmography. PRV surrogates for the Cardiovascular Autonomic Modulation (CvAM) and provides a snapshot of psychophysiological homeostasis of the body. Objective: The paper investigates the roles of (a) physiological factors, e.g., Age, Duration of illness, Heart Rate (HR), Respiration Rate (RR), SpO2 level, and (b) popular digital biomarkers, such as SDNN, LF/HF, RMSSD, pNN50, SD1/SD2 to evaluate the cardiac risk. The paper hypothesizes that low FEV1, which is another physiological factor, plays a critical role in defining such risk. Method: A total of 50 males and females each, suffering from Chronic Obstructive Pulmonary Disease (COPD) took the Lyfas test after appropriate ethical measures. Data, thus collected by Lyfas had been statistically analyzed using histogram plots and Kolmogorov-Smirnov test for normality check, Pearson's Correlations (PC) to measure the strength of associations, and linear regressions to test the goodness of fit of the model. Results: Positive PCs are noted between (a) RMSSD and SDNN ('very high'-females: 0.86 and males: 0.91), (b) pNN50 and RMSSD (PC: moderate 0.46), (c) pNN50 and SDNN (PC: moderate 0.44), (d) Duration of illness and Age ('high'-females: 0.71 and males: 0.77), and (e) Age and RR ('high'-females: 0.67, males: 0.53). Negative PC is noted between (a) LF/HF and FEV1 ('moderately high'-males 0.42) and (b) LF/HF and SpO2 ('moderately high'-males 0.30). Although the R2 values are not so encouraging (most are < 0.5), yet, the models are statistically significant (p-values 0.0336; CI 95%). Conclusion: The paper concludes that Lyfas may be used to predict the cardiac risk in COPD patients based on the LF/HF values correlated to SpO2 and FEV1 levels.
A Cell Culture Chip with Transparent, Micropillar-Decorated Bottom for Live Cell Imaging and Screening of Breast Cancer Cells

In the recent years, microfabrication technologies have been widely used in cell biology, tissue engineering, and regenerative medicine studies. Today, the implementation of microfabricated devices in cancer research is frequent and advantageous because it enables the study of cancer cells in controlled microenvironments provided by the microchips. Breast cancer is one of the most common cancers in women, and the way breast cancer cells interact with their physical microenvironment is still under investigation. In this study, we developed a transparent cell culture chip (Ch-Pattern) with a micropillar-decorated bottom that makes live imaging and monitoring of the metabolic, proliferative, apoptotic, and morphological behavior of breast cancer cells possible. The reason for the use of micropatterned surfaces is because cancer cells deform and lose their shape and acto-myosin integrity on micropatterned substrates, and this allows the quantification of the changes in morphology and through that identification of the cancerous cells. In the last decade, cancer cells were studied on micropatterned substrates of varying sizes and with a variety of biomaterials. These studies were conducted using conventional cell culture plates carrying patterned films. In the present study, cell culture protocols were conducted in the clear-bottom micropatterned chip. This approach adds significantly to the current knowledge and applications by enabling low-volume and high-throughput processing of the cell behavior, especially the cell–micropattern interactions. In this study, two different breast cancer cell lines, MDA-MB-231 and MCF-7, were used. MDA-MB-231 cells are invasive and metastatic, while MCF-7 cells are not metastatic. The nuclei of these two cell types deformed to distinctly different levels on the micropatterns, had different metabolic and proliferation rates, and their cell cycles were affected. The Ch-Pattern chips developed in this study proved to have significant advantages when used in the biological analysis of live cells and highly beneficial in the study of screening breast cancer cell–substrate interactions in vitro.
Stunting and Underweight, but not Wasting are Associated with Delay in Child Development in Southwest Ethiopia

Background Stimulating care during childhood is the foundation for optimal health, learning, productivity, and social well-being throughout the life course. In addition, malnutrition is a major public health concern affecting up to half of children under-five years in Ethiopia. However, evidence on the causal contribution of malnutrition to delay in child development is poorly understood in Ethiopia. Objective To identify the relationship between different forms of malnutrition and delay in child development among children in Southwest Ethiopia. Methods A community-based survey was conducted among 507 randomly selected mother–child pairs in the Guraghe Zone, Southwest Ethiopia. A pretested tool and validated anthropometric measurements were used. Anthropometric indices (WFH, WFA, and HFA) were calculated in Anthros software. The data were summarized in mean, median, standard deviation, tables and charts. Bivariable and multivariable binary logistic regression (stepwise backward regression) models were fitted with nutritional status (wasting, stunting and underweight) and other potential factors associated with delay in child developmental. Adjusted odds ratios with 95% confidence intervals and p-values were reported. Results A total of 507 mother–child (12–59 months) pairs were included in the survey (97% response rate). The mean ASQ-3 score was 150 (± 23.4), with a minimum and maximum score of 45 and 270, respectively. A total of 149 (29.4%; 95% CI: 25.4–33.4) children had developmental delays, where 17.2%, 16.8%, 13.4%, 10.8%, and 10.1% had delays in gross motor, communication, problem-solving, personal-social, and fine motor skills, respectively. Children of working mothers (AOR=2.9; 1.8, 4.8), preterm births (AOR=3.2; 1.4, 7.0), early initiation of complementary feeding (AOR=2.5; 1.37, 4.6), stunting (AOR=3.0; 1.9, 4.7), underweight (AOR= 2.3; 1.1, 4.7) and low dietary diversity score (AOR=3.1; 1.3, 7.5), were predictors of developmental delay. Conclusion Child development delay is a public health concern and it is strongly associated with stunting, underweight, undiversified dietary consumption, and suboptimal infant and young child feeding practices.
Awareness and Utilization of Library Services among Secondary School Students in Yenagoa LGA of Bayelsa State

Library services are vital services that form an integral part of the learning and training process of children. Despite its integral role in the education of an individual, there have been reports of poor utilization of library services around the world. This study thus set out to determine the level of awareness of library services, the utilization of library services as well as the factors affecting utilization of these services among secondary school students in Yenagoa LGA of Bayelsa State. The descriptive research design was employed in conducting this study among junior secondary two and senior secondary one and two students of government secondary schools located within the Yenagoa Local Government Area of Bayelsa State. A sample size of 391 was used. The study instrument was a semi-structured, self-administered questionnaire that consisted of four sections. Data was analyzed using the Statistical Package for Social Sciences (SPSS) version 20 and relationships between variables were statistically tested using the chi-squared bivariate analytical test. Statistical significance was set at the 0.05. The overall level of awareness regarding library services in this study was found to be low with a grand mean of 2.01 out of 4. The level of use of library services was found to be low (mean: 2.29). Certain factors both affected library services utilization to both high and low extents. The respondents’ gender as well as the level of provision of library services was significantly related with the utilization of library services. It was concluded that awareness of library services as well as the utilization of these services by secondary school students was low. It was recommended that the provision of required books, reading materials and lacking resources in these schools be made to foster library usage among students in these schools.
Zero Tillage, Residue Retention and System-Intensification with Legumes for Enhanced Pearl Millet Productivity and Mineral Biofortification

Pearl millet-based cropping systems with intensive tillage operations prior to sowing have limited sustainable productivity in the low-irrigation conditions of semi-arid farming ecologies, such as those in the north Indian plains. The adoption of improved management practices such as zero tillage with residue retention (ZTR) and diversification with the inclusion of summer pulse crops has the potential to improve cropping system sustainability. Therefore, an experiment was designed to compare two improved management practices, zero tillage (ZT) and ZTR, to conventional tillage (CT), across three pearl millet-based cropping systems: pearl millet–chickpea (PM–CP), PM–CP–mungbean (MB), and PM–CP–forage pearl millet in a two-year experiment. Experimental treatments were compared in terms of pearl millet productivity, mineral biofortification, and greenhouse gas emissions. Results showed a significant increase in pearl millet yield attributes, grain and stover productivity, nutrient uptake, and micronutrient biofortification in the PM–CP–MB cropping system under ZTR relative to other treatment combinations. On-farm evaluation at different locations also showed that the intensification of PM–CP system using summer crops enhanced pearl millet productivity across diverse tillage systems. Overall, zero tillage practices combined with diversified pearl millet-based cropping systems are likely to be management practices, which farmers can use to sustainably maintain or increase cropping system productivity in the various semi-arid areas of the world.