Miracle-dz/UniFAR-FTUs huggingface dataset:
A matching-adjusted indirect treatment comparison of elranatamab in patients with triple-class exposed relapsed/refractory multiple myeloma: Comparisons with belantamab mafodotin, selinexor plus dexamethasone, and real-world physician’s choice of treatment.

e20038 Background: Elranatamab, a bispecific antibody targeting B-cell maturation antigen on multiple myeloma (MM) cells and CD3 on T cells, is being evaluated as a monotherapy in the MagnetisMM-3 trial (MM3; NCT04649359) in patients with triple-class exposed (TCE) relapsed/refractory MM. While there is no standard of care for TCE MM, belantamab mafodotin (belamaf) and selinexor plus dexamethasone (sel-dex) are treatment options. LocoMMotion is a prospective, non-interventional study investigating real-world physician’s choice of treatment (PCT) in patients with TCE MM. In the absence of head-to-head trials, unanchored matching-adjusted indirect comparisons (MAIC) were conducted to compare the relative efficacy across comparators. Methods: Individual patient-level data were obtained for elranatamab from MM-3 (data cut Oct 2022). Aggregated data for belamaf, sel-dex, and PCT were obtained from DREAMM-2 (NCT03525678), STORM (NCT02336815), and LocoMMotion (NCT04035226). Unanchored MAICs were conducted to compare the relative treatment effect on objective response rate (ORR) accounting for potential different distributions of prognostic variables (PVs) and effect modifiers (EMs). In the base case, PVs identified via logistic regressions based on MM-3 data were adjusted. In sensitivity analyses, PVs/EMs identified from the literature were added. Relative treatment effects were measured by rate differences and odds ratios. Results: After MAIC adjustments, the selected PVs/EMs were balanced in each comparison. The table presents the results from the naïve comparison with no MAIC adjustment plus the MAIC base case. The ORR of elranatamab was statistically higher than belamaf, sel-dex, and PCT in LocoMMotion. Results were consistent across all sensitivity analyses. Conclusions: Elranatamab had a significantly higher ORR than belamaf, sel-dex, and real-world PCT in LocoMMotion for patients with TCE MM, demonstrating its clear clinical benefit for this population. [Table: see text]
Stability Analysis and Time-switching Rule Design for the Switched Continuous-time and Discrete-time Systems

In this paper, we investigate stability analysis and time-switching sequence design for the switched continuous-time and discrete-time systems. In many applications, a simple switching rule is need for the switched systems. We address the generalized problem of stability for the switched continuous-time and discrete-time systems whose switching structure does depend on time-driven switching strategy. The stability conditions of the switched continuous-time and discrete-time system were built and then the range for the stability was computed by solving the conditions.
Mesoscale Model Simulations of Three Heavy Precipitation Events in the Western Mediterranean Region

A mesoscale numerical model with parameterized moist convection is applied to three cases involving heavy rainfall in the western Mediterranean region. Forecast precipitation fields, although not perfect when compared to the observations of rainfall, appear to have sufficient information to be considered useful forecasting guidance. The results illustrate that a good simulation for this type of event in a region with complex topography is strongly dependent on a good initialization and prediction of the low-level flow and water vapor distribution. For two of the cases that have a marked synoptic-scale contribution, the simulations give reasonably accurate predictions of the precipitation distribution, although the amounts are generally underestimated. The third case exhibits relatively subtle synoptic-scale forcing and is dominated by isolated convective storms (mostly over the sea) that also produced severe thunderstorms (including tornadoes), and the prediction of precipitation is not as promising. Overall, the results are encouraging in terms of potential application of mesoscale models operationally in the western Mediterranean region. Additional experiments beyond the ‘‘control’’ simulations have been performed to isolate the influence of orography and water vapor flux from the Mediterranean Sea on the model simulations. This factor separation indicates that both effects can be important contributors to a successful forecast. Suggestions are offered for future efforts in pursuing the application of mesoscale models to this forecast problem.
for Homogeneous Product Networks

In this paper, we develop generalized methods to layout homogeneous product networks with any number of dimensions, and analyze their VLSI complexity by deriving upper and lower bounds on the area and maximum wire length. In the literature, lower bounds are generally obtained by computing lower bounds on the bisection width or the crossing number of the network being laid out. In this paper, we define a new measure that we call "maximal congestion," that can be used to obtain both the bisection width and the crossing number, thereby unifying the two approaches. Upper bounds are traditionally obtained by constructing layouts based on separators or bifurcators. Both methods have the basic limitation that they are applicable only for graphs with bounded vertex degree. The separators approach generally yields good layouts when good separators can be found, but it is difficult to find a good separator for an arbitrary graph. The bifurcators approach is easier to apply, but it generally yields larger area and wire lengths. We show how to obtain "strong separators" as well as bifurcators for any homogeneous product network, as long as the factor graph has bounded vertex degree. We illustrate application of both methods to layout a number of interesting product networks. Furthermore, we introduce a new layout method for product networks based on the combination of collinear layouts. This method is more powerful than the two methods above because it is applicable even when the factor graph has unbounded vertex degree. It also yields smaller area than the earlier methods. In fact, our method has led to the optimal area for all of the homogeneous product networks we considered in this paper with one exception, which is very close to optimal. In regards to wire lengths, the results obtained by our method turned out to be the best of the three methods for all the examples we considered, again subject to one (and the same) exception. We give an extensive variety of such examples.
The parametrically maintained Foucault pendulum and its perturbations

A Foucault pendulum may be maintained indefinitely by parametric excitation, but as a consequence of imperfections in its construction, seismic noise and other perturbations it is liable to precess at other than the ideal rate. It has been suggested by Braginsky et al. (Phys. Rev. Lett. 53, 863 (1984)) that the disturbing factors might be reduced to such an extent that the Thirring-Lense effect of General Relativity could be verified. The present analysis reveals serious problems in addition to those they considered, but indicates how parametric excitation helps to overcome them. Nevertheless their assessment of the chance of success reflects an optimism that the present author cannot share.
Anisotropic magnetoresistance in Ga1-xMnxAs

We have measured the magnetoresistance in a series of Ga 1 - x Mn x As samples with 0.033≤x≤0.053 for three mutually orthogonal orientations of the applied magnetic field. The spontaneous resistivity anisotropy (SRA) in these materials is negative (i.e., the sample resistance is higher when its magnetization is perpendicular to the measuring current than when the two are parallel) and has a magnitude on the order of 5% at temperatures near 10 K and below. This stands in contrast to the results for most conventional magnetic materials where the SRA is considerably smaller in magnitude for those few cases in which a negative sign is observed. The magnitude of the SRA drops from its maximum at low temperatures to zero at T c in a manner that is consistent with mean-field theory. These results should provide a significant test for emerging theories of transport in this new class of materials.
Nonlinear secondary flow through a rotating channel

The stability of fluid through a channel subject to a system rotation of constant rate about the spanwise axis is considered. In contrast to previous studies, a strongly nonlinear bifurcation approach is used to solve for a family of two-dimensional, steady, streamwise-orientated vortex flows. A stability analysis of these flows is also performed. All of the two-dimensional flows considered lose stability to an Eckhaus (streamwise-independent) secondary disturbance in a steady bifurcation to another member of the solution set. This property, given also that lower-order primary and secondary disturbance modes can become unstable, leads to a rich structure of bifurcation relationships between the secondary flows. With increasing Reynolds number, the secondary flow arising from the linear critical point first loses stability to the Eckhaus instability, and then loses stability to a fundamental spanwise mode with small streamwise wavenumber. With a further increase in Reynolds number, the secondary flow then also becomes unstable to a disturbance of subharmonic spanwise and $O(1)$ streamwise wavenumber, and finally (on the upper solution branch) a disturbance of fundamental spanwise and $O(1)$ streamwise wavenumber. Other types of bifurcation for possible tertiary flows are also identified. By superimposing the secondary disturbance onto the secondary flow, visualizations of the possible structure of the bifurcating tertiary flows are obtained. The visualizations show low-speed streaks in the streamwise velocity component lying between a set of staggered vortices for superharmonic bifurcations, and between aligned vortices for subharmonic bifurcations. Excellent qualitative and quantitative agreement is found with previous experimental results and direct-numerical-simulation-based stability studies, and good overall agreement with previous DNS studies was also found.
Equivalence Relations on Algebraic Curves

Much has been wi-ritten on the possibility of extending the classical theory of linear equivalence on an algebraic curve to more general equivalence relations in which the group of all principle divisors is replaced by certain proper subgroups. Noether's theory of non-adjoint curves (see the end of this paper for references) is essentially a theory of this sort. Similarly the problem considered by a number of analysts of generalizing the classical Jacobi inversion theorem to differentials with singularities is in the same general direction. Severi's recent "Funzioni Quasi Abeliane" (which contains a large bibliography) includes a systematic account of what, in our language, is the equivalence relation on a curve with ordinary double points and cusps. Our present work deals with the algebraic aspects of the general problem; transcendental matters and generalized jacobian varieties will be treated later. For the general concepts involved, we refer to Zariski 1 and Chevalley.
Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors

Abstract Purpose: Microsatellite instability (MSI) is currently the only predictive biomarker of efficacy of immune checkpoint inhibitors (ICI) in metastatic colorectal cancers (mCRC). However, 10% to 40% of patients with MSI mCRC will experience a primary resistance to ICI. Experimental Design: In two cohorts of patients with MSI mCRC treated with ICI (exploratory, N = 103; validation, N = 35), 3′ RNA sequencing was performed from primary tumors. Previously described single-cell transcriptomic signatures of tumor microenvironment (TME) were analyzed. Results: In the exploratory cohort, the unsupervised clustering allowed the identification of three clusters of tumors with distinct transcriptional profiles: cluster A (“stromalHIGH-proliferationLOW”), cluster B (“stromalHIGH-proliferationMED”), and cluster C (“stromalLOW-proliferationHIGH”), with an enrichment of patients progressing at first disease assessment under ICI in cluster A (30% vs. 12% in cluster B and 8.1% in cluster C; P = 0.074). Progression-free survival (PFS) was also significantly shorter in patients belonging to cluster A, compared with clusters B or C (P < 0.001) with 2-year PFS rates of 33.5%, 80.5%, and 78.3%, respectively. In multivariate analysis, PFS was still significantly longer in patients belonging to cluster B [HR, 0.19; 95% confidence interval (CI), 0.08–0.45; P < 0.001] and cluster C (HR, 0.25; 95% CI, 0.10–0.59; P = 0.02), compared with patients belonging to cluster A. The association of this clustering with PFS under ICI was confirmed in the validation cohort. PFS related to non–ICI-based regimens was not significantly different according to cluster. Conclusions: This unsupervised transcriptomic classification identified three groups of MSI mCRCs with different compositions of TME cells and proliferative capacities of TME/tumor cells. The “stromalHIGH-proliferationLOW” cluster is associated with a poorer prognosis with ICI treatment.
Contract Management and Operational Performance of the Road Construction Sector in Uganda: Evidence from the Uganda National Roads Authority

The study examined the effect of contract management on operational performance of the road construction sector in Uganda, a case of the Uganda National Roads Authority (UNRA) paying attention to three objectives: to examine the effect of contract administration; relationship management and contract monitoring on operational performance of UNRA. A cross sectional research design was used on a sample of 108 participants from whom questionnaires were used to collect data. SPSS (version 25) was adopted to process data while analysis was done through descriptive and inferential statistics. Findings revealed that all tenets of contract management studied are positively related to operational performance (contract administration: r = 0.53; p < 0.01, relationship management: r = 0.644; p < 0.01 and contract monitoring: r = 0.469; p <0.01). Results revealed that contract management explains 41.3% of the variation in operational performance of UNRA and that contract administration, relationship management and contract monitoring have a positive effect on operational performance with net contributions of 42%, 34.7% and 24.6% respectively. The researchers conclude that contract management positively predicts operational performance. The researchers recommend that the authorities at UNRA should pay keen attention to all dimensions of contract management adopted in the study since they all positively relate with and equally positively influence operational performance of the organization. By doing so, any occurrences that would jeopardize smooth flow of activities and works will be eliminated, hence harnessing operational efficiency.
Multiparameter seismo-ionospheric anomaly observation before the 2008 Wenchuan, China, Mw7.9 earthquake

Abstract The atmosphere-ionosphere response before 2008 Mw7.9 Wenchuan earthquake based on global positioning system (GPS), detection of electro-magnetic emission transmitted from earthquake regions (DEMETER), and National Oceanic and Atmospheric Administration—advanced very high resolution radiometer (NOAA/AVHRR) satellite data is analyzed. It is found that GPS total electron content (TEC) above the epicenter continuously decreased in the afternoon periods from 6 to 10 May but increased in the afternoon of 9 May. Contour analysis on ionospheric plasma using Instrument Sonde de Langmuir data onboard DEMETER satellite showed that electron density (Ne) and ion density (Ni) was also reduced from 6 to 10 May, the anomalous region mainly distributed in the south of the epicenter, conforming to the anomalous TEC area. The brightness temperature ( T b ) from NOAA/AVHRR data, calculated by K index method, shows a noticeable enhancement on the northwest side of the epicenter on 7 May, while ion temperature ( T i ) from DEMETER data increased on 9 May with the order of ∼ 12.5 % . The energetic particle flux presents an obvious enhancement for the spectrum at 100 to 600 keV energy range on 6 May. Preliminary study suggests the perturbations of these parameters (TEC, Ne, Ni, T b , and T i ) before the Wenchuan earthquake may be related to the changes of vertical electric field in the atmosphere and ionosphere, induced by the enhancement of stress in tectonic regions and the electromagnetic signal propagation from the earthquake preparation area.
Differentiating Between Mass-forming Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma: A Challenging Clinical Approach

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a tumor of the pancreas that has a 5-year survival rate as low as 7.8%. In cases of chronic pancreatitis, it is sometimes challenging to rule out neoplastic changes, as mass-forming pancreatitis (MFCP) that can occur secondary to long-lasting inflammation can commonly mimic the presentation of pancreatic ductal adenocarcinoma. The clinical picture, laboratory, and radiological imaging of PDAC and MFCP may sometimes overlap, resulting in a higher incidence of misdiagnosis and unnecessary surgery. Aim: We aim to describe the various tools available to help physicians distinguish between mass-forming chronic pancreatitis and pancreatic ductal adenocarcinoma. Methods: A literature search was conducted on “PubMed” using the following terms: pancreatic carcinoma, mass-forming chronic pancreatitis, and pancreatic mass. Several articles discussing imaging modalities including ultrasound, CT-scan, and MRI; and laboratory markers including cancer antigen 19–9 (CA 19-9), carcinoembryonic antigen (CEA), glypican-1 (GP-1), low-density lipoprotein receptor (LDLR), and K-RAS, were reviewed. Discussion: Despite their similar presentations, the management of MFCP and PDAC is very different. The similarity in history, clinical symptoms, and imaging findings can lead to unnecessary procedures. In this review, we examined several modalities that physicians might use to avoid any misdiagnosis. Conclusion: Although none of these tests alone has been shown to be superior to the others, a potential suggestion might be to use a combination of these tests to allow a reliable diagnosis.
Order statistics for a special class of unequally correlated multinormal variates

The moments of the order statistics for independent normal variables are well known and used for many purposes including the determination of the moments of censored normal populations. Selection programs in plant and animal breeding routinely use the average of the expectations of the s top-ranking order statistics as the standardized selection differential in the prediction of genetic gain. In many cases, the assumptio~ of independence may not be satisfied as, for example, when the population under selection is composed of individuals with varying degrees of genetic relationship. The present study Was prompted by the need for some understanding of the effect of unequal correlations on the order statistics, ordering without regard to the genetic relationships. One abstraction of this problem is to assume that the sample of n individuals consists of m full-sib families with k
Fixed-structure controller design for systems with actuator amplitude and rate non-linearities

In this paper we develop output feedback controllers and fixed-order (i.e., full- and reduced-order) dynamic compensators for systems with actuator amplitude and rate saturation constraints. The proposed design methodology employs a rate limiter as part of the controller architecture. The problem of simultaneous control amplitude and rate saturation is embedded within an optimization problem by constructing a Riccati equation whose solution guarantees closed-loop global/local asymptotic stability in the face of sector bounded actuator amplitude and rate non-linearities. Application of the proposed framework is demonstrated via a flight control example involving actuator amplitude and rate saturation constraints.
The Role of Job Characteristics, Organizational Citizenship Behavior, Self-Efficacy in the Relationship to Employee Performance

Employee productivity is crucial since it forms the basis and guide for every firm. However, the nature and formality of the work organization play a significant role in determining job characteristics, and although they have an impact on other workplace circumstances, changing job characteristics has inherent restrictions. The purpose of this study is to examine the structural relations among job characteristics, organizational citizenship behavior, self-efficacy related employee performance. The samples of this study consist of 351 representatives utilizing a straightforward irregular inspecting procedure and information from respondents utilizing research instruments utilizing on the web surveys. The exploration technique utilized in this study is Structural Equation Modelling examination and information investigation instruments utilizing SmartPLS 3.3. 3. Analysis and interpretation of the data indicate that; self-efficacy have a relationship with employee performance, job characteristics have a relationship with employee performance, organizational citizenship behavior have a relationship with employee performance. The implementation of job characteristics, organizational citizenship behavior, and self-efficacy will greatly impact and make a positive contribution to the hotel activities in improving the performance of its employees.
Inertial particle approximation to solutions of the Shallow Water Equations on the rotating spherical Earth

The present study assesses the relationship between solutions of the mechanical problem of particle motion on the surface of a rotating sphere subject only to the gravitation force (called inertial particle motion) and the fluid dynamical problem there, described by the shallow water equations (SWE). Trajectories of fluid parcels advected by a time-dependent velocity field subject to the SWE on the sphere are computed numerically and compared to analytical formulae of inertial particle trajectories. In addition, the free surface height of an ensemble of noninteracting particles is estimated within the classical mechanics framework and compared to computed height of the SWE. The comparison between solutions of the two systems shows very good qualitative as well as quantitative agreement for times of several inertial periods in the following basic low-energy cases: inertial particle oscillations in mid-latitudes (corresponding to inertial waves in fluid dynamics) and inertial motion near the equator. Moreover, for realistic values of the reduced gravity (gH of 1 to 100 m 2 s −2 ) and for time interval of 1‐2 d the periods of the trajectories of fluid parcels nearly coincide with those of inertial particles. These results are obtained for a wide range of initial velocity fields and they imply that, at least for time intervals considered, the Coriolis force dominates the motion even after the pressure gradient forces become sufficiently large to affect the motion. They also highlight the fact that fluid parcels of non-linear inertial waves are subject to the same westward drift as inertial particles and provide an explanation for existence of so called ‘inertial peak’ in the internal oceanic wave spectrum.