Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast and Accurate 3-D Registration of HR-pQCT Images

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new noninvasive bone imaging technology that generates high-resolution 3-D images for quantitatively analysis of the bone microarchitecture in human. To enable quantitative evaluation of bone changes, either bone gain or loss, accurate alignment between the baseline and follow-up scans of the same individual is necessary. The major difficulties in achieving efficient and automatic registration of the HR-pQCT data are the large data size, deformations in the nonskeletal structures, and the complexity of the trabecular bone geometry. In this paper, we propose an automatic surface-based approach for fast and accurate registration of the HR-pQCT data, where the rigid registration is applied on the surfaces of the bony structures extracted from the grayscale HR-pQCT. The bony structure segmentation is performed via an automatic method that can adaptively determine the thresholds for separating the bony structure from the background and nonskeletal tissues. Experimental results performed on ten pairs of baseline and follow-up wrist scans of five adolescents and five elderly patients with osteoporosis showed the advantage of the proposed method in the high degree of automation, while the resultant parameters describing bone mineral density and trabecular architecture after registration were comparable with the outputs of the scanner's software. This automatic and accurate matching procedure may contribute to the clinical application and research of HR-pQCT.
CPS: A Cooperative-Probe Based Failure Detection Scheme for Application Layer Multicast

The failure of non-leaf nodes in Application Layer Multicast (ALM) tree partitions the multicast tree, which may significantly degrade the quality of multicast service. Accurate and timely failure recovery from node failures in ALM tree, which is based on the premise of efficient failure detection scheme, is critical to minimize the disruption of service. In fact, failure detection has hardly been studied in the context of ALM. Firstly, this paper analyzes the failure detection issues in ALM and then proposes a model which is based on the relationship between parent and child nodes for it. Secondly, the Cooperative-Probe based failure detection Scheme (CPS), in which the information about probe loss is shared among monitor nodes, is designed. Thirdly, the performance of CPS is analyzed. The Numerical results show that our proposed scheme can simultaneously reduce the detection time and the probability of false positive at the cost of little increased control overhead by comparing with the Basic-Probe based failure detection Scheme (BPS). Finally, some possible directions for the future work are discussed.
III—Faultless Disagreement

There seem to be topics on which people can disagree without fault. For example, you and I might disagree on whether Picasso was a better artist than Matisse, without either of us being at fault. Is this a genuine possibility or just apparent? In this paper I pursue two aims: I want to provide a systematic map of available responses to this question. Simultaneously, I want to assess these responses. I start by introducing and defining the notion of a faultless disagreement. Then I present a simple argument to the conclusion that faultless disagreement is not possible. Those who accept the argument have to explain away apparent cases of faultless disagreement. Those who want to maintain the possibility of faultless disagreement must deny one of the argument's premisses. The position I want to promote belongs to the latter category and is a form of genuine relativism.
Both RNA-binding domains in heterogenous nuclear ribonucleoprotein A1 contribute toward single-stranded-RNA binding.

Heterogenous nuclear ribonucleoproteins (hnRNPs) such as hnRNP A1 are tightly associated with heterogenous nuclear RNAs (hnRNAs) within eukaryotic nuclei and are thought to be involved in hnRNA processing and splice site selection. The NH2-terminal two-thirds of hnRNP A1 contains two 92-amino acid RNA binding domains (RBDs) that are arranged in tandem and are more than 30% homologous with each other. Following this region is a flexible glycine-rich COOH-terminal domain. We have studied the nucleic acid binding properties of the two isolated RBDs (residues 1-92 and 93-184, respectively) and of A1 fragments corresponding to residues 1-184 and 1-196 (i.e., the latter fragment is called UP1) in order to evaluate their relative contributions to A1 binding. We have determined that the individual RBDs of A1 bind poly[r(epsilon A)], a fluorescent single-stranded RNA (ssRNA), with a surprisingly low apparent association constant of only 1.5 x 10(4) M-1 (1-92) and 4.5 x 10(4) M-1 (93-184), respectively. We hypothesize that this low affinity represents a basal level of binding that is common to most RBD-containing proteins. Oligonucleotide binding studies suggest the interaction site size for the 93-184 fragment is approximately 4 nucleotides or less and salt sensitivity studies indicate that only about 27% of the free energy of binding of this RBD derives from ionic interactions. Since the affinity of the 1-184 fragment is at least 10-fold above that of either of its component RBDs, both must contribute to binding. This conclusion is further supported by the increased occluded site size of 1-184 (n = 14 +/- 2), as compared to its 93-184 RBD (n = 6 +/- 1), and by the biphasic binding that was observed for the UP1:poly(U) interaction at pH 6.0. Our finding that the affinity of the 1-184 fragment is 1000-fold less than the product of the affinities of its 1-92 and 93-184 RBDs is consistent with these domains being joined by a flexible linker. By comparing the affinities of the 1-184 fragment with that for A1, we conclude that together the two RBDs in A1 account for only 53% of the free energy of A1 binding. Comparative binding studies with UP1 demonstrate that the short region spanning residues 185-->195 represents an important determinant of the binding affinity of A1 and, since this region contains a site of dimethylation, it may provide a mechanism for regulating the affinity of A1 for specific nucleic acid targets.
Computer automated multi-paradigm modelling for analysis and design of traffic networks

Computer automated multiparadigm modelling (CAMPaM) is an enabler for domain-specific analysis and design. Traffic, a new untimed visual formalism for vehicle traffic networks, is introduced. The syntax of traffic models is meta-modelled in the entity-relationship diagrams formalism. From this, augmented with concrete syntax information, a visual modelling environment is synthesized using our CAMPaM tool AToM/sup 3/, a tool for multiformalism and meta-modelling. The semantics of the traffic formalism is subsequently modelled by mapping traffic models onto Petri net models. As models' abstract syntax is graph-like, graph rewriting can be used to transform models. The advantages of a domain-specific formalism such as traffic as opposed to a generic formalism such as Petri nets are presented. We demonstrate how mapping onto Petri nets allows one to employ the vast array of Petri net analysis techniques. A coverability graph is generated and conservation analysis is automated by transforming this graph into an integer linear programming specification.
Melt Mixing as Method to Disperse Carbon Nanotubes into Thermoplastic Polymers

Abstract This paper presents melt mixed composites where two ways of introducing nanotubes in polymer matrices were used. In the first case, commercially available masterbatches of nanotube/polymer composites are used as the starting materials that are diluted by the pure polymer in a subsequent melt mixing process (masterbatch dilution method) while in the other case nanotubes are directly incorporated into the polymer matrix. As an example of the masterbatch dilution method, composites of polycarbonate with MWNT are presented which are produced using a Brabender PL‐19 single screw extruder. In this system, electrical percolation was found at about 0.5 wt% MWNT. The nanotube dispersion as observed by TEM investigations is quite homogeneous. The direct incorporation method is discussed in composites of polycarbonate with MWNT and SWNT. For commercial MWNT percolation was found between 1.0 and 3.0 wt% depending on the aspect ratio and purity of the materials. For HiPCO‐SWNT from CNI percolation occurred between 0.25 wt% and 0.5 wt% SWNT. The incorporation of nanotubes significantly changes the stress‐strain behavior of the composites: modulus and stress are enhanced; however, the elongation at break is reduced especially above the percolation concentration.
An Iterative Learning Algorithm for Deciphering Stegoscripts: a Grammatical Approach for Motif Discovery

Steganography, or information hiding, is to conceal the existence of messages so as to protect their conﬁdentiality. We consider de-ciphering a stegoscript, a text with secret messages embedded within a covertext, and identifying the vocabularies used in the mes-sages, with no knowledge of the vocabularies and grammar in which the script was writ-ten. Our research was motivated by the prob-lem of identifying conserved non-coding func-tional elements (motifs) in regulatory regions of genome sequences, which we view as stego-scripts constructed by nature with a statis-tical model consisting of a dictionary and a grammar. We develop an iterative learning algorithm, WordSpy, to learn such a model from a stegoscript. The model then can be applied to identify the embedded secret mes-sages, i
Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol

ABSTRACT Cholesterol is an essential component of metazoan cellular membranes and it helps to maintain the structural integrity and fluidity of the plasma membrane. Here, we developed a cholesterol biosensor, termed D4H, based on the fourth domain of Clostridium perfringens theta-toxin, which recognizes cholesterol in the cytosolic leaflet of the plasma membrane and organelles. The D4H probe disassociates from the plasma membrane upon cholesterol extraction and after perturbations in cellular cholesterol trafficking. When used in combination with a recombinant version of the biosensor, we show that plasmalemmal phosphatidylserine is essential for retaining cholesterol in the cytosolic leaflet of the plasma membrane. In vitro experiments reveal that 1-stearoy-2-oleoyl phosphatidylserine can induce phase separation in cholesterol-containing lipid bilayers and shield cholesterol from cholesterol oxidase. Finally, the altered transbilayer distribution of cholesterol causes flotillin-1 to relocalize to endocytic organelles. This probe should be useful in the future to study pools of cholesterol in the cytosolic leaflet of the plasma membrane and organelles.
PET imaging of (86)Y-labeled anti-Lewis Y monoclonal antibodies in a nude mouse model: comparison between (86)Y and (111)In radiolabels.

UNLABELLED Absorbed doses in (90)Y radioimmunotherapy are usually estimated by extrapolating from (111)In imaging data. PET using (86)Y (beta(+) 33%; half-life, 14.7 h) as a surrogate radiolabel could be a more accurate alternative. The aim of this study was to evaluate an (86)Y-labeled monoclonal antibody (mAb) as a PET imaging agent and to compare the biodistribution of (86)Y- and (111)In-labeled mAb. METHODS The humanized anti-Lewis Y mAb hu3S193 was labeled with (111)In or (86)Y through CHX-A"-diethylenetriaminepentaacetic acid chelation. In vitro cell binding and cellular retention of radiolabeled hu3S193 were evaluated using HCT-15 colon carcinoma cells, a cell line expressing Lewis Y. Nude mice bearing HCT-15 xenografts were injected with (86)Y-hu3S193 or (111)In-hu3S193. The biodistribution was studied by measurements of dissected tissues as well as by PET and planar imaging. RESULTS The overall radiochemical yield in hu3S193 labeling and purification was 42% +/- 2% (n = 2) and 76% +/- 3% (n = 6) for (86)Y and (111)In, respectively. Both radioimmunoconjugates specifically bound to HCT-15 cells. When cellular retention of hu3S193 was studied using (111)In-hu3S193, 80% of initially cell-bound (111)In activity was released into the medium as high-molecular-weight compounds within 8 h. When coadministered, in vivo tumor uptake of (86)Y-hu3S193 and (111)In-hu3S193 reached maximum values of 30 +/- 6 and 29 +/- 6 percentage injected dose per gram and tumor sites were easily identifiable by PET and planar imaging, respectively. CONCLUSION At 2 d after injection of (111)In-hu3S193 and (86)Y-hu3S193 radioimmunoconjugates, the uptake of (111)In and (86)Y activity was generally similar in most tissues. After 4 d, however, the concentration of (86)Y activity was significantly higher in several tissues, including tumor and bone tissue. Accordingly, the quantitative information offered by PET, combined with the presumably identical biodistribution of (86)Y and (90)Y radiolabels, should enable more accurate absorbed dose estimates in (90)Y radioimmunotherapy.
Combustion Studies in Rocket Motors

I A PREVIOUS paper (l), 3 experiments with a rocket motor having a full-length observation window were described. Special emphasis was devoted to the presentation of photographs showing combustion under unstable operation. It is the purpose of this paper to describe some recent experiments both with the window-motor assembly and normal developmental water-cooled motors which present further data on the phenomenon of instability. The reactants used in all experiments were ethyl alcohol and liquid oxygen.
Can fermions save large N dimensional reduction

This paper explores whether Eguchi-Kawai reduction for gauge theories with adjoint fermions is valid. The Eguchi-Kawai reduction relates gauge theories in different numbers of dimensions in the large N limit provided that certain conditions are met. In principle, this relation opens up the possibility of learning about the dynamics of 4D gauge theories through techniques only available in lower dimensions. Dimensional reduction can be understood as a special case of large N equivalence between theories related by an orbifold projection. In this work, we focus on the simplest case of dimensional reduction, relating a 4D gauge theory to a 3D gauge theory via an orbifold projection. A necessary condition for the large N equivalence between the 4D and 3D theories to hold is that certain discrete symmetries in the two theories must not be broken spontaneously. In pure 4D Yang-Mills theory, these symmetries break spontaneously as the size of one of the spacetime dimensions shrinks. An analysis of the effect of adjoint fermions on the relevant symmetries of the 4D theory shows that the fermions help stabilize the symmetries. We consider the same problem from the point of view of the lower dimensional 3D theory and find that, surprisingly, adjoint fermions are not generally enough to stabilize the necessary symmetries of the 3D theory. In fact, a rich phase diagram arises, with a complicated pattern of symmetry breaking. We discuss the possible causes and consequences of this finding.
Computer-Supported Collaborative Production

This paper proposes the concept of collaborative production as a focus of concern within the general area of collaborative work. We position the concept with respect to McGrath's framework for small group dynamics and the more familiar collaboration processes of awareness, coordination, and communication (McGrath 1991). After reviewing research issues and computer-based support for these interacting aspects of collaboration, we turn to a discussion of implications for how to design improved support for collaborative production. We illustrate both the challenges of collaborative production and our design implications with a collaborative map-updating scenario drawn from the work domain of geographical information systems.
Polymersomes in polymersomes: multiple loading and permeability control.

With such a compartmentalized structure, a mol-ecule encapsulated in the inner liposome, would have topermeate through two successive membranes, instead of asingle one before leaking into the outside environment. Thisdouble-membrane effect was demonstrated by observing theserumhalf-lifeofciprofloxacindrugincreasingfrom10 mininsingle liposomes to 6 h in vesosomes.
Density Displays for Data Stream Monitoring

In many business applications, large data workloads such as sales figures or process performance measures need to be monitored in real‐time. The data analysts want to catch problems in flight to reveal the root cause of anomalies. Immediate actions need to be taken before the problems become too expensive or consume too many resources. In the meantime, analysts need to have the “big picture” of what the information is about. In this paper, we derive and analyze two real‐time visualization techniques for managing density displays: (1) circular overlay d isplays which visualize large volumes of data without data shift movements after the display is full, thus freeing the analyst from adjusting the mental picture of the data after each data shift; and (2) variable resolution density displays which allow users to get the entire view without cluttering. We evaluate these techniques with respect to a number of evaluation measures, such as constancy of the display and usage of display space, and compare them to conventional d isplays with periodic shifts. Our real time data monitoring system also provides advanced interactions such as a local root cause analysis for further exploration. The applications using a number of real‐world data sets show the wide applicability and usefulness of our ideas.
Hybrid Nanocomposite Coatings for Application in Construction Materials: Tribological Study

The Nanocomposite group of AIDICO and the Nanomaterials Group of University of Valencia collaborate in the research of new organic-inorganic hybrid materials with application in construction products. Tribological properties and good thermal stability are some of the required specifications for such applications. Some hybrid coatings based on simultaneous formation of epoxy and silica networks are introduced in this work. Elastic modulus and hardness obtained from TDMA analyses and indentation techniques, together with thermal stability by TGA, are the main properties analysed in order to fulfil the requirements for construction coating applications. New routes for obtaining these coatings based on sol-gel have been explored.
PolyU's Experimentation with Guided Summarization

In addition to the familiar tasks of update summarization and automatic summary evaluation, the TAC 2010 summarization track includes a new task: guided summarization. It is designed to “encourage a deeper linguistic (semantic) analysis of the source documents” in order to generate a summary guided by a given set of aspects. The new task is an upgrade of query-focused summarization in that an automatic summary is to meet more specific and semantically structured user need. The upgrade demonstrates the growing inclination for semantically oriented summarization, whilst posing new challenges to traditional frameworks and techniques. The update summarization and the automatically evaluating summaries of peers (AESOP) tasks are similar to those included in the TAC 2009 summarization track. The PolyU team has participated in both tasks of the TAC 2010 summarization track, including the guided summarization task and the AESOP. The guided summarization task is an unfamiliar one, with few success or failure stories. Our team takes up this new challenge, not widely studied in the summarization community, with techniques based on Information Extraction (IE). For the AESOP task, we also experiment with some new techniques. In the following, we report the system design for the tasks as well as findings and diagnoses from our experimentation.
P fimbriae enhance the early establishment of Escherichia coli in the human urinary tract

This study examined the role of P fimbriae in the establishment of bacteriuria. Patients (n = 17) were subjected to intravesical inoculation with an asymptomatic bacteriuria strain, Escherichia coli 83972, or its P‐fimbriated (pap+/prs+) transformants. As shown by groupwise analysis, the pap+/prs+ transformants established bacteriuria more rapidly than E. coli 83972 (P = 0.021) and required a lower number of inoculations to reach 105 cfu ml−1 (P = 0.018). Intraindividual analysis showed that the pap+/prs+ transformants established bacteriuria more rapidly than E. coli 83972 in the patients who subsequently became carriers of both strains. Finally, bacterial establishment was shown to vary with the in vivo expression of P fimbriae. Bacterial counts were higher when P‐fimbrial expression was detected than when the pap+/prs+ strain showed a negative phenotype. The results suggested that P fimbriae enhance the establishment of bacteriuria and fulfil the molecular Koch postulates as a colonization factor in the human urinary tract.
Inflammatory carcinoma of the breast.

ALTHOUGH inflammatory carcinoma of the breast is an entity well known to surgeons, it is comparatively uncommon, comprising only about 1 to 4% of all breast carcinomas. Since it clinically simulates an inflammatory process, it frequently is difficult to diagnose. In 14 (18.9%) of the 74 cases seen at the Mayo Clinic between 1933 and 1945, 1 the condition was erroneously diagnosed "inflammatory disease" before the true carcinomatous nature was discovered. When full-blown it resembles erysipelas, and dermatologists may be consulted for diagnosis and treatment. The condition is only briefly mentioned in the dermatologic texts, and in the American dermatologic literature there is but one report of inflammatory, or erysipeloid, breast carcinoma. Leavell and Tillotson 2 in a recent issue of the A. M. A.Archives of Dermatology and Syphilologyreport the case of a woman who died of a breast carcinoma exhibiting three types of
Phagocytosis and antigen presentation in dendritic cells

Summary: Like macrophages and neutrophils, dendritic cells (DCs) are considered professional phagocytes. Even if the three cell types phagocytose parasites, bacteria, cell debris, or even intact cells very efficiently, the functional outcomes of the phagocytic event are quite different. Macrophages and neutrophils scavenge and destroy phagocytosed particles, a critical step in innate immunity. DCs, in contrast, have developed means to ‘preserve’ useful information from the ingested particles that serve to initiate adaptive immune responses. Thus, both phagosomal degradation and acidification are much lower in DCs than in macrophages or neutrophils. Reduced degradation results in the conservation of antigenic peptides and in their increased presentation on major histocompatibility complex class I and II molecules. In this article, we review the mechanisms that control this delicate equilibrium between phagosomal degradation/cytotoxicity and antigen presentation in the different families of phagocytes.
Vortex Solutions of the High-κ High-Field Ginzburg-Landau Model with an Applied Current

In this paper, we study the single-vortex solutions of a two-dimensional high-$\kappa$ high-field Ginzburg–Landau model of superconductivity with a constant applied current. Under a nondegeneracy condition and for appropriate ranges of the applied magnetic field and applied current, we construct some special solutions which, up to a constant shift of phase in time, are the stationary solutions of the model equation. Our result provides partial justification for the existence of a critical applied current which is the one important step towards a rigorous mathematical characterization of the interactions between the quantized vortices and applied electric current.