Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the quality of CPR performed by a single lifeguard, two lifeguards and a lifeguard with a bystander after water rescue: a quasi-experimental trial

Background High-quality cardiopulmonary resuscitation (CPR) could improve survival of drowning victims. The purpose of the study is to assess the impact of fatigue caused by water rescue on subsequent CPR quality and the influence of a bystander’s participation on CPR quality in a lifeguard rescue. Methods This was a simulated quasi-experimental study with a sample of 14 lifeguards and 13 laypersons. Each lifeguard performed 2 min single-rescuer CPR as baseline measurement. In three separate trials, a single lifeguard swam 50 m to perform a water rescue in a pool and returned with the manikin another 50 m. After each rescue, 10 min of CPR was performed by a single lifeguard, two lifeguards or a lifeguard with a layperson with no CPR training. Paired t-test and repeated analysis of variance were used to analyse CPR quality variables. Results Baseline CPR quality was adequate for most measures except compression depth and re-expansion. After water rescue, the single lifeguard trial showed no significant differences compared with baseline. CPR score and ventilation score of the single-lifeguard trial was higher than that of the lifeguard-bystander trial (p=0.027, p<0.001). Both the two-lifeguard trial (p=0.025), and lifeguard-bystander trial (p=0.010) had a lower percentage of breaths with correct ventilation volume and higher percentage of breaths with excessive ventilation volume (p=0.007, p=0.011, respectively) than the single-lifeguard trial. No-flow time of the lifeguard-bystander trial was longer than other trials (p<0.001). Conclusions Although CPR given by the lifeguard was not optimal, fatigue generated by a water rescue has no impact on the quality of subsequent CPR performed by a trained lifeguard for 10 min. Untrained bystanders assisting in CPR in a drowning event is unlikely to be helpful.
The phase relationship between the pyrazinamide polymorphs α and γ.

Pyrazinamide is an active pharmaceutical compound for the treatment of tuberculosis. It possesses at least four crystalline polymorphs. Polymorphism may cause solubility problems as the case of ritonavir has clearly demonstrated; however, polymorphs also provide opportunities to improve pharmaceutical formulations, in particular if the stable form is not very soluble. The four polymorphs of pyrazinamide constitute a rich system to investigate the usefulness of metastable forms and their stabilization. However, despite the existence of a number of papers on the polymorphism of pyrazinamide, well-defined equilibrium conditions between the polymorphs appear to be lacking. The main objectives of this paper are to establish the temperature and pressure equilibrium conditions between the so-called α and γ polymorphs of pyrazinamide, its liquid phase, and vapor phase and to determine the phase-change inequalities, such as enthalpies, entropies, and volume differences. The equilibrium temperature between α and γ was experimentally found at 392(1) K. Moreover, vapor pressures and solubilities of both phases have been determined, clearly indicating that form α is the more stable form at room temperature. High-pressure thermal analysis and the topological pressure-temperature phase diagram demonstrate that the γ form is stabilized by pressure and becomes stable at room temperature under a pressure of 260 MPa.
Effect of Toxoplasmosis on hematological, biochemical and immunological parameters in pregnant women in Tikrit city, Iraq

The aim of the present study was to detect the effect of infection with Toxoplasma gondii on hematological, biochemical and immunological parameters in pregnant women. Blood samples, 101 in the total number, were subject to serological test (ELISA test) collected between first of September 2013 to the end of March 2014 from pregnant women: 76 seroposative toxoplasmosis and (25) seronegative toxoplasmosis (control group) divided into two groups according to their ages (16-26 years and 27-46 years). Hematological parameters in whole blood samples were examined. Liver enzyme activity such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline Phosphatase (ALP) also urea and creatinine concentration in serum were determined. Besides, the levels of interleukins (IL-6 and IL-10) were analyzed. In infected groups WBCs counts, ALT, AST, ALP activities, urea and creatinine concentration, IL-6 and IL-10 levels were increased significantly p≤0.05, while the Hb and PCV levels decreased significantly p≤0.05 when compared to control groups.
Targeted therapies for patients with moderate-to-severe psoriasis: a systematic review and network meta-analysis of PASI response at 1 year

Abstract Purpose To compare PASI outcomes of approved biologics and apremilast after 1 year of treatment. Methods A systematic review identified RCTs and long-term extensions reporting PASI 75, 90, and 100 responses in adults with moderate-to-severe psoriasis. Data for analysis were modeled using a Bayesian multinomial likelihood model with probit link. Results Twenty-eight studies reporting PASI responses were included in the network meta-analysis. Differences in study design led to a stepwise approach to synthesis, consisting of two analyses. The primary analysis included nine RCTs investigating comparative efficacy at 1 year. Results indicated risankizumab, brodalumab, and guselkumab were the most effective therapies, followed by ixekizumab and secukinumab; all demonstrated superiority to ustekinumab and etanercept. The secondary analysis extended the primary analysis with 19 further studies comparing active interventions to placebo outcomes extrapolated from induction. The interventions generating the highest PASI response were the same as the primary analysis. These therapies were more effective than apremilast, ustekinumab, adalimumab, certolizumab, etanercept, and infliximab. Conclusions This NMA demonstrated that evaluated IL-17 and IL-23 inhibitors outperformed other biological therapies after 1 year. Risankizumab had a higher probability of achieving PASI outcomes than all other biologics, except brodalumab and guselkumab, where no significant difference could be concluded.
Prognostic analysis of histopathological images using pre-trained convolutional neural networks: application to hepatocellular carcinoma

Histopathological images contain rich phenotypic descriptions of the molecular processes underlying disease progression. Convolutional neural networks, state-of-the-art image analysis techniques in computer vision, automatically learn representative features from such images which can be useful for disease diagnosis, prognosis, and subtyping. Hepatocellular carcinoma (HCC) is the sixth most common type of primary liver malignancy. Despite the high mortality rate of HCC, little previous work has made use of CNN models to explore the use of histopathological images for prognosis and clinical survival prediction of HCC. We applied three pre-trained CNN models—VGG 16, Inception V3 and ResNet 50—to extract features from HCC histopathological images. Sample visualization and classification analyses based on these features showed a very clear separation between cancer and normal samples. In a univariate Cox regression analysis, 21.4% and 16% of image features on average were significantly associated with overall survival (OS) and disease-free survival (DFS), respectively. We also observed significant correlations between these features and integrated biological pathways derived from gene expression and copy number variation. Using an elastic net regularized Cox Proportional Hazards model of OS constructed from Inception image features, we obtained a concordance index (C-index) of 0.789 and a significant log-rank test (p = 7.6E−18). We also performed unsupervised classification to identify HCC subgroups from image features. The optimal two subgroups discovered using Inception model image features showed significant differences in both overall (C-index = 0.628 and p = 7.39E−07) and DFS (C-index = 0.558 and p = 0.012). Our work demonstrates the utility of extracting image features using pre-trained models by using them to build accurate prognostic models of HCC as well as highlight significant correlations between these features, clinical survival, and relevant biological pathways. Image features extracted from HCC histopathological images using the pre-trained CNN models VGG 16, Inception V3 and ResNet 50 can accurately distinguish normal and cancer samples. Furthermore, these image features are significantly correlated with survival and relevant biological pathways.
Fin type and flutter technique: a study to optimise the oxygen consumption in divers

Abstract The purpose of this research was to assess the variability of the oxygen consumption (VO2) depending on fin type and the flutter technique used for the different divers’ profile. Twenty-three SCUBA divers took part in four 2.5 hour sessions to evaluate a total of six fin models and two flutter techniques. The flutter routines lasted 30 minutes per fin and per technique. Measurements of VO2 significantly decreased on Jet (20.42 ml*min−1*kg−1) and XShot fin (20.87 ml*min−1*kg−1) compared to Twin Jet fin (22.81 ml, p < 0.05). In addition, the VO2 was in all cases higher in certified divers than in professional divers (23.87 and 19.00 ml*min−1*kg−1, p = 0.00). These differences were significant between divers’ profile and flutter technique (p < 0.05). Similarly, measurements of VO2 were higher in frog kick technique than crawl kick technique (22.97 ml*min−1*kg−1 and 19.96 ml*min−1*kg−1, p = 0.00). These differences were significant between fin type and flutter technique in all fins (p = 0.03). Practitioner summary: This study investigated the impact of fin type, flutter technique and divers’ profile on VO2 during diving. Results of this research suggest that combination a diving different factors significantly impacts the divers’ VO2, thus providing new perspective for election of fin type and flutter technique according to the divers’ profile.
Factors shaping community patterns of protists and bacteria on a European scale.

Factors shaping community patterns of microorganisms are controversially discussed. Physical and chemical factors certainly limit survival of individual taxa and maintenance of diversity. In recent years, a contribution of geographic distance and of dispersal barriers to distribution patterns of protists and bacteria has been demonstrated. Organismic interactions such as competition, predation and mutualism further modify community structure and maintenance of distinct taxa. Here we address the relative importance of these different factors in shaping protists and bacterial communities on a European scale using high-throughput sequencing data obtained from lentic freshwater ecosystems. We show that community patterns of protists are similar to those of bacteria. Our results indicate that cross-domain organismic factors are important variables with a higher influence on protists as compared to bacteria. Abiotic physical and chemical factors also contributed significantly to community patterns. The contribution of these latter factors was higher for bacteria, which may reflect a stronger biogeochemical coupling. The contribution of geographical distance was similar for both microbial groups. This article is protected by copyright. All rights reserved.
Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial.

Importance Increasing evidence suggests that sleep-disordered breathing (SDB) increases the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms underlying the link between SDB and Alzheimer disease are still unclear. Objective To determine which brain changes are associated with the presence of SDB in older individuals who are cognitively unimpaired, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism. Design, Setting, and Participants This cross-sectional study was conducted using data from the Age-Well randomized clinical trial of the Medit-Ageing European project, acquired between 2016 and 2018 at Cyceron Center in Caen, France. Community-dwelling older adults were assessed for eligibility and were enrolled in the Age-Well clinical trial if they did not meet medical or cognitive exclusion criteria and were willing to participate. Participants who completed a detailed neuropsychological assessment, polysomnography, a magnetic resonance imaging, and florbetapir and fluorodeoxyglucose positron emission tomography scans were included in the analyses. Main Outcomes and Measures Based on an apnea-hypopnea index cutoff of 15 events per hour, participants were classified as having SDB or not. Voxelwise between-group comparisons were performed for each neuroimaging modality, and secondary analyses aimed at identifying which SDB parameter (sleep fragmentation, hypoxia severity, or frequency of respiratory disturbances) best explained the observed brain changes and assessing whether SDB severity and/or SDB-associated brain changes are associated with cognitive and behavioral changes. Results Of 157 participants initially assessed, 137 were enrolled in the Age-Well clinical trial, and 127 were analyzed in this study. The mean (SD) age of the 127 participants was 69.1 (3.9) years, and 80 (63.0%) were women. Participants with SDB showed greater amyloid burden (t114 = 4.51; familywise error-corrected P = .04; Cohen d, 0.83), gray matter volume (t119 = 4.12; familywise error-corrected P = .04; Cohen d, 0.75), perfusion (t116 = 4.62; familywise error-corrected P = .001; Cohen d, 0.86), and metabolism (t79 = 4.63; familywise error-corrected P = .001; Cohen d, 1.04), overlapping mainly over the posterior cingulate cortex and precuneus. No association was found with cognition, self-reported cognitive and sleep difficulties, or excessive daytime sleepiness symptoms. Conclusions and Relevance The SDB-associated brain changes in older adults who are cognitively unimpaired include greater amyloid deposition and neuronal activity in Alzheimer disease-sensitive brain regions, notably the posterior cingulate cortex and precuneus. These results support the need to screen and treat for SDB, especially in asymptomatic older populations, to reduce Alzheimer disease risk. Trial Registration ClinicalTrials.gov Identifier: NCT02977819.
Indonesia

Indonesia has responded with a bold and comprehensive policy package to cushion the impact of the COVID-19 pandemic. The economy rebounded in the third quarter of 2020, and the economic recovery is projected to strengthen in 2021 and 2022. Strong policy support and an improving global economy will be the main drivers initially, and greater mobility and confidence will follow with the planned vaccination program in 2021. The uncertainty surrounding the growth outlook is larger than usual. Early completion of a widespread vaccination program is an upside risk, while a protracted pandemic remains a downside risk. The macro-financial fallout of the pandemic and economic downturn could be larger than expected, and credit conditions could be slow to improve. Ongoing reforms aimed at promoting investment are expected to help mitigate the scarring effects from the pandemic and put the economy on a sustained growth path that builds on Indonesia’s favorable demographics.
Aortic stenosis in women

Aortic stenosis (AS) is a common valve disorder in an ageing population in western countries, and women, with longer life expectancy, comprise a substantial percentage of elderly patients with AS. Compared with men, women exhibit distinctive characteristics at the level of stenotic valve leaflets and subsequent compensatory responses of the left ventricle to chronic pressure overload, and in clinical presentation, consequences and response to intervention. Randomised controlled trials of transcatheter aortic valve implantation have yielded new evidence of sex differences in both short-term and long-term outcomes after intervention. A comprehensive knowledge of the existing evidence may inform our understanding of gender differences during assessment and treatment of patients with AS. In this paper, we review the available evidence regarding sex differences in AS in terms of symptoms, clinical presentation, anatomical differences and pathophysiological progression, management and outcomes after aortic valve replacement. Implications for further research are suggested.
Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams

The present study was conducted to characterize the metabolome of accessory gland fluid (AGF) of locally adapted Morada Nova rams, raised in the Brazilian Northeast. AGF was collected by an artificial vagina from five vasectomized rams. Metabolites were identified by gas chromatography‐mass spectrometry (GC/MS) and high‐performance liquid chromatography‐mass spectrometry (LC/MS), with the support of Human Metabolome Database, PubChem, LIPID Metabolites, Pathways Strategy databases, and MetaboAnalyst platforms. There were 182 and 190 metabolites detected by GC/MS and LC/MS, respectively, with an overlap of one molecule. Lipids and lipid‐like molecules were the most abundant class of metabolites in the ram AGF (127 compounds), followed by amino acids, peptides, and analogs(103 metabolites). Considering all GC/MS and LC/MS, fructose, glycerol, citric acid, d‐mannitol, d‐glucose, and l‐(+)‐lactic acid were the most abundant single metabolites present in the ram AGF. Meaningful pathways associated with AGF metabolites included glycine, serine and threonine metabolism; pantothenate and CoA biosynthesis; galactose metabolism; glutamate metabolism and phenylalanine metabolism, and so forth. In conclusion, the combined use of LC/MS and GC/MS was essential for getting a holistic view of the compounds embedded in the ram AGF. Chemical analysis of the accessory sex gland secretion is relevant for understanding sperm function and fertilization.
Healthcare workers’ perspectives on availability and accessibility of the prevention of mother-to-child-transmission programme in North West province, South Africa

Background: Despite the availability of prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) services, many factors and reasons prevent mothers from accessing these services. HIV prevalence is still high among South African women of reproductive age and mother-to-child-transmission (MTCT) is a concern. This study ascertained the perspectives of healthcare workers regarding availability and accessibility of the PMTCT programme. Objective: To explore and describe the perspectives of healthcare workers regarding availability and accessibility of the PMTCT programme. Method: Qualitative research with exploratory-descriptive design was utilised. Data were collected from 21 healthcare workers using three focus-group discussions. The participants were selected based on rendering the PMTCT programme services for more than two years. Moreover, the participants had undergone training, formal education and continuous support on the PMTCT programme. Three large clinics were selected as the main clusters of the sub-district. Tesch’s method was used to analyse the qualitative data. Results: Healthcare workers indicated ineffective utilisation of the PMTCT programme services by HIV-positive pregnant women. Most women had challenges with child feeding owing to limited knowledge. Another challenge indicated by healthcare workers was lack of resources. It is important that recommendations be implemented to assist with availability and accessibility of the PMTCT programme. Conclusion: Availability and accessibility of PMTCT programme services are still problematic. The study has the potential to inform development of strategies that may facilitate access to care for PMTCT programme clients.
Antimicrobial residues survey by LC-MS in food-producing animals in Lebanon

ABSTRACT The treatment of animals with antimicrobial products may lead to the contamination of edible tissues by their residues, which may represent a risk to human health. Therefore, this study aimed to determine the level of antimicrobial residues in food-producing animals (chicken, beef, and milk) in Lebanon. A total of 310 samples were collected and analysed using an LC-MS/MS for the determination of 48 compounds belonging to different families in order to map their compliance according to the European Commission decision 2002/657/EC. Results show that 60% of the analysed samples were not contaminated by any residue, while 12% presented a concentration higher than the MRLs for tetracyclines, sulphonamides, quinolones, and macrolides. Results revealed that chicken were the most contaminated by antimicrobial residues, when compared to beef and milk. The obtained results demonstrate the uncontrolled use of antimicrobials in some Lebanese farms and claim for better management of livestock.
Burnout in anesthesiology and intensive care. Is there a problem in Germany

Background. With the demands faced by anesthetists and intensive care physicians apparently increasing continuously in Ger- many, the increased risk of burnout in com- parison with the general working popula- tion is discussed. This debate has previously been merely speculative because of the lack of studies comparing the burn-out risk of the German working population with anesthe- tists. Accordingly it was not certain whether anesthetists really are at greater risk of devel- oping burnout as has often been suggested. Moreover, age, gender, function, workplace environment, e.g. working at a hospital com- pared to a general practitioner (GP) surgery, may influence the risk of burnout. There- fore, this study examined whether the risk for anesthetists in Germany suffering from burnout really is greater than in other occu- pations. In addition, factors influencing the burnout risks of anesthetists were analyzed. Method. A total of 3,541 questionnaires completed by German aaesthetists for a study on work satisfaction by the CBI (Co- penhagen Burnout Inventory, part of the Co- penhagen Psychosocial Questionnaire, COP- SOQ) were analyzed. Apart from calculating the number of participants with a high risk
Stimulation of water and calcium dynamics in astrocytes with pulsed infrared light

Astrocytes are non‐neuronal cells that govern the homeostatic regulation of the brain through ions and water transport, and Ca2+‐mediated signaling. As they are tightly integrated into neural networks, label‐free tools that can modulate cell function are needed to evaluate the role of astrocytes in brain physiology and dysfunction. Using live‐cell fluorescence imaging, pharmacology, electrophysiology, and genetic manipulation, we show that pulsed infrared light can modulate astrocyte function through changes in intracellular Ca2+ and water dynamics, providing unique mechanistic insight into the effect of pulsed infrared laser light on astroglial cells. Water transport is activated and, IP3R, TRPA1, TRPV4, and Aquaporin‐4 are all involved in shaping the dynamics of infrared pulse‐evoked intracellular calcium signal. These results demonstrate that astrocyte function can be modulated with infrared light. We expect that targeted control over calcium dynamics and water transport will help to study the crucial role of astrocytes in edema, ischemia, glioma progression, stroke, and epilepsy.