Miracle-dz/UniFAR-FTUs huggingface dataset:
The Use of Shotblocker for Subcutaneous Injection P ain, Anxiety and Satisfaction in Chronic Spontaneous Urticaria Patients: A Randomized Controlled Trial

Background: In chronic diseases such as chronic spontaneous ur ticaria (CSU), after subcutaneous injection, problem s such as pain, ecchymosis and hematoma may arise due to t h injection technique. Aim: The aim of this study was to investigate the effec t of shotblocker on pain, anxiety and satisfaction levels in subcutaneous injection of CSU patients. Methods: A randomized placebo-controlled was used for this study. Data were collected by including 90 patients out of 125 patients in Turkey. Patients were divided into three groups as interven tion, control and shotblocker group. Results: In this study; 76.7% of the patients in the shotbl ocker group stated that had no fear of injection, 8 6.7% of them had subcutaneous omalizumab injections 5 times or more, and 76.7% of them found that the injections were m ildly painful. The satisfaction of the shotblocker group after injecti on was found to be statistically significant from t he other groups. As a result of the assessment of pain and level of anxiety afte r inj ction; there was not statistically significan t difference between shot blocker, placebo and control groups. Conclusion: It is thought that shotblocker might be presented to patients as an option on account of it is easy a nd cost effective to use. It is recommended to support the result with further studies, since there have not b een any similar study examples in subcutaneous (SC) omalizumab injection i n chronic spontaneous urticaria patients.
The influence of Ginkgo Biloba on hepatic gene expression of (PGC1-α, PPAR-α and GLUT-2), liver, kidney functions, hematological and lipid profile in type I diabetic rats

Ginkgo biloba is one of a well-known medicinal plant worldwide, where is prescribed in working on various diseases, such as diabetes mellitus type I and II, peripheral vascular abnormalities, and neurodegenerative illnesses like Alzheimer's disease . The purpose of this study was to know how oral Ginkgo biloba administration affected the liver, kidneys, hematological parameters, lipid profile, and hepatic gene expression in type I diabetic rats. Seventy-five male adult Sprague Dawely rats were allocated into five equal groups 15 rats each, 1st group; control group, 2nd group; diabetic group, 3rd group; Ginkgo biloba group, 4th group; Diabetic treated group received single oral dose of Ginkgo biloba after diabetic induction as a treatment and 5th group; rats were administered daily single oral dose of Ginkgo biloba as a protective dose from the 1st day of the study prior to diabetes induction and continued after the diabetes induction till the end of the work. The results of study revealed that Ginkgo biloba actions in modulating of hepatic key genes GLUT-2 (glucose transporter-2), PPAR-α (Peroxisome proliferator-activated receptor alpha), and PGC1-α (The peroxisome proliferatoractivated receptor gamma coactivator-1). Also, Ginkgo biloba possesses antihyperlipidemic activities, supports liver and kidney functions and improves glucose metabolism, storage and utilization in liver by enhancing its key genes. based on the outcomes of current study Ginkgo biloba is an effective food supplement or a supportive treatment for type I diabetes mellitus.
The Impact of Different Estrus Synchronization Programs on Postpartum Holstein Dairy Cow Reproductive Performance

Adel Hussien, Heba Sharawy, Yasser Y Lenis, Daniela Jaimes, Ozge Turna, Engy Risha, Wael Eldomany, Samy Zaabel, Mohammed Elmetwally 1Department of Theriogenology, Faculty of veterinary medicine, Mansoura University, Mansoura 35516, Egypt 2Departamento de Ciencia Animal, Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, Palmira, Colombia 3 Bogota, Colombia Faculty of Agricultural Sciences, University of Applied and Environmental Sciences U.D.C.A. 3 4Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey 5Department of Clinical pathology, Faculty of veterinary medicine, Mansoura University, Mansoura 35516, Egypt
Early Thymoquinone Injections and Expression of DNA Repair Enzymes in Hamster Buccal Pouch-Induced Dysplasia

Because carcinogenesis is a multi-step process, Sporn (1976) suggested that the best time to control cancer is in its “preneoplastic” phase, before it has a chance to develop into “invasive” cancer. Therefore, the aim of the present work was to evaluate the effect of TQ on the dysplasia induced in that model, through IHC expression of both enzymes.6 weeks of DMBA painting resulted in irreversible genetic changes that did not resolve by the studied repair enzymes. So it can be proposed that TQ had resulted in regression of the carcinogenesis process through the following mechanisms. First: TQ as a potent antioxidant that antagonizes the adverse effect resulting from elevated ROS levels due to carcinogenesis i.e. reduction of the intracellular ROS allowed the repair enzymes to fulfill their main target.Second: TQ through inactivation of the TNF-Nf-κB pathway, and in turn induced p53 activation, i.e. stimulated apoptosis of malignant cells. Third: TQ has the ability to arrest cells at different phases of the cell cycle leading to growth inhibition, so allowing repair of mutated cells
TGF-β Paradox and the Progression of Osteoblastoma versus Osteosarcoma.

Objective: To study the expression of Transforming Growth Factor beta-1 (TGF-β1) and Tumor protein 53 (Tp53) in osteoblastoma and osteosarcoma and the role of TGF-β paradox in the progression of these tumors. Materials and Methods: Twenty-two paraffin blocks were collected and classified into 7 blocks with classical osteoblastoma and 15 blocks with osteosarcoma. From each block, slide preparation for H&E and immunohistochemical staining by two markers: anti TGF-β1 antibody and anti Tp53 antibody were applied. Then we estimated the expression of each marker by ImageJ (version 1.41) and area fractions were measured. Results: Both classical osteoblastoma and osteosarcoma showed positive expression of TGF-β1. The expression of Tp53 was positive in osteosarcoma, but it was negative in osteoblastoma. Our statistical analysis revealed that the expression of TGF-β1 in osteosarcoma was stronger than in osteoblastoma but with no statistically significant difference. There was a significant moderate negative correlation between expression of the two markers in osteosarcoma. Conclusion: The mutual signaling is the main pillar in the progression of osteosarcoma and osteoblastoma. Interaction pathways between Tp53 and TGF-β1 may have a role in TGF-β paradox. Understanding this interaction may help in improving of the management and prognosis of osteosarcoma.
GENETIC Parameters for some Productive and Reproductive Traits for First Lactation in Egyptian Buffalo

A total of 2054 records of primiparous buffalo cows calved during 2000-2019 was collected from five Egyptian buffalo herds. The studied traits were birth weight (BW), total milk yield (TMY), lactation period (LP), age at first calving (AFC), gestation length (GL), days open (DO), and calving interval (CI). Year and season of calving, sex and herd were used as fixed effects. Genetic parameters were estimated using two models, the first model to estimate variance components and heritability, and the second model was estimated the genetic correlations among studied traits. Results showed that the heritability values were moderate for BW, LP and TMY (0.48, 0.23 and 0.50, respectively), suggesting that genetic improvement programs using the selection could be effective to improve these traits, but all reproductive traits were low, being 0.07, 0.02 0.0 and 0.12 for GL, DO, CI, and AFC, respectively, inferring that these traits could be improved using environmental and marginal conditions. The genetic correlation of the current study indicated that the selection for increasing BW of Egyptian buffalo could be followed by an improvement of TMY, longer LP and GL. The genetic correlation between productive traits and reproductive traits were positive ranged from 0.04 (TMY-AFC) to 0.91 (LP-DO and LP-CI). Selection of buffalo to reproduction traits would be ineffective or take long time because they are influenced by farm management, unlike productive traits.
Detection of Lead and Cadmium Residues in Various Tissues of Broiler in Omdurman Locality- Khartoum State- Sudan

Quick Response Code Abstract: The objective of this study was to evaluate the possible bioaccumulation of certain heavy metals – namely Lead (Pb) and Cadmium (Cd) -in the internal parts of chickens. A total of 80 chicken muscles, kidney, liver and gizzard samples (20 of each) were randomly collected from different chicken farms, in Omdurman localitySudan. Water samples were also obtained from the water reservoir in each farm. Then wet digestion of samples was done followed by the use of Atomic Absorption Spectrometer (AAS) to measure the level of Pb and Cd. The two heavy metals were found to be present in all studied parts of the chickens. The concentration of Cd varies significantly within the poultry tissue but fall within the permissible limits for meat consumption set by the FAO and Sudanese Standards and Metrology Organization (SSMO). The mean values of Cd were 0.013 ±0. 001μg/g, 0.033±0. 002μg/g, 0.028 ± 00. 005μg/g and 0.037±0. 003μg/g, in muscles, kidneys liver and gizzard respectively. The concentration of Cd in water was 0.0031±0. 003μg/l which was within the permissible limits. The level of Pb varied significantly within the poultry tissue but was above the permissible limits. The mean values of Pb in gizzard was the highest followed by kidney then liver and the least concentration was detected in muscles 0.224±0.013μg/g, 0.295±0. 007μg/g,0.266±0. 014μg/g and 0.350±0. 026μg/g respectively, while the concentration in water was 0.150±0. 006μg/ and was also higher than the permissible limits. Precocious steps must be taken to monitor and reduce the concentrations of lead in water and feed used by poultry farmers. Also governmental efforts are needed to control the environmental pollution which may be an additional source for contamination.
Basement and cover rock history in western Tethys: HT-LP Geological Society, London, Special Publications

High-temperature-low-pressure metamorphism of the deep crust is probable during continental lithospheric extension. The 75-65 Ma cooling ages of metamorphic and magmatic rocks preserved in overthrust crystalline slices in the southern Aegean are most plausibly explained by late Cretaceous extension of the Apulian continental margin, rather than by subduction-related magmatism. Metamorphism and magmatism at depth can be correlated with those stratigraphic features of the cover sequences that indicate extension. In particular, the puzzling 'premier flysch' of the region is interpreted as one consequence of peripheral uplift associated with stretching.
Effects of Cultural Stress on Identity Development and Depression among Hispanic College Students

ABSTRACT Hispanic emerging adults are routinely faced with a variety of cultural stressors that adversely impact mental health and compromise identity development. Given that identity emerges through day-to-day interactions, there is a need to explore the impact of cultural stress on identity development and depressive symptoms at the micro-level (across days). To address these gaps, the current study utilized a 12-day diary study conducted among 792 Hispanic college students (75.9% female, M age = 20.14 years, SD = 1.85, Range = 18–24 years) to determine the impact of cultural stress on daily identity coherence, identity confusion, depressive symptoms, and the association between identity coherence and confusion and depressive symptoms in this population. Results indicated that Day 1 cultural stress positively predicted average daily depressive symptoms and identity confusion and negatively predicted identity coherence. Finally, cultural stress predicted a stronger daily association between identity confusion and depressive symptoms. As a whole, our findings emphasize the detrimental impact that cultural stressors have on both identity development and depressive symptoms at the daily level. These results are discussed in relation to the specific types of cultural stressors that Hispanic emerging adults face, and the need for appropriate intervention and prevention efforts for this population is emphasized.
Nanoparticles-Phenolics as Anti Salmonella Typhimurium

The present study was designed to evaluate the activities of six phenolic compounds. Their activities against the potential foodborne pathogen S. Typhimurium were assessed using macro dilution and spectrophotometric methods. Their activities were in the order of thymol > benzoic acid > coumarin > cinnamic acid > curcumine > gallic acid. Thymol was bactericidal at a concentration of 0.08 mg /ml. With exception of curcumine, other phenolics revealed bactericidal effect in concentration varied from 1.25 to 10.00 mg/ml. Minimum inhibitory concentration (MICs) values by spectrophotometric method were significantly different compared to visual method in some antimicrobial assays. Coating fish with solutions of thymol or chitosan nanoparticle (CNPs) significantly reduced salmonella population. The nanostructured thymol CNPs capsule controlled the release of thymol and the effect in fish matrix continued significant during cold storage without adverse effect on pH value. The tested phenolics have the potential to be used in development of food coating technology. Also the formulated nanocapsule is promising in controlling the hazard of S. Typhimurium in fish.
Serum interleukins 2 and 10 in juvenile systemic lupus erythematosus: relation to disease activity

INTRODUCTION Juvenile systemic lupus erythematosus (j-SLE) is an autoimmune inflammatory disease that affects children ≤ 18 years. It represents 15–20% of all SLE patients. It is characterized by systemic inflammation and a wide spectrum of circulating autoantibodies due to dysfunctional immune regulation. 2 Interleukins have an important role in the pathogenesis of SLE and they are considered to be disease biomarkers because their levels vary with disease activity. So, they could be used as therapeutic targets. They are produced by T helper (Th) cells. IL-2 is a monomeric glycoprotein that is produced by Th1 and CD4+ T lymphocytes. It plays a critical role in immune homeostasis and regulation. Patients lacking IL-2 expression have defective immune responses. The induction of antiIL-2 autoantibodies and decreased its serum level may have a role in the occurrence of SLE activity. IL-10 is produced by regulatory Th cells (Treg), Th2, and CD8+ T lymphocytes. It plays an important role in B cell activation and autoantibody production. Also, it has direct inhibitory effects on the proliferation of CD4+ T cells and Th1 cytokines production such as IL2. IL-10 is defined as a potent stimulator of B lymphocytes and it stimulates the production of anti-DNA auto-antibodies in SLE patients. The overproduction of IL-10 may have a role in the occurrence of SLE activity. This study was conducted to evaluate serum levels of IL-2 and IL-10 and to calculate their ratio in relation to the disease activity in a group of children and adolescence with SLE.
Determination of friction coefficient in the lubricated ring upsetting with palm kernel oil for cold forging of aluminum alloys

Metal forming Tribology Palm oil Cold forging Friction Bio-lubricant The growing of worldwide trend for promoting the use of the renewable material such as vegetable oil is due to the increasing concern about environmental damage that caused by the use of mineral oil which is not biodegradable. This article is present as a case study in highlighting the use of Palm Kernel Oil (PKO) as a bio lubricant in cold forging process. Ring Compression Test (RCT) plays a fundamental role in our understanding of materials science and engineering due to the deformation, friction and wear behaviour. Annealed Aluminium (AA6061) were used in this test to observe the formation of the ring with different sample test (NO-Oil, PKO and CMFOoil) at 10%, 20% 30% and 40% formation by comparing with finites element method (DEFORM-3D) to predict formation of the sample lubricants. The ring compression test conducted by this study indicates that the Tresca friction factor (m) is higher for Palm Kernel oil (0.35) compare to commercial metal forming oil (CMFO) (0.25), where higher load is needed under palm kernel oil test. Palm Kernel oil however has a better in surface protecting to the material where it shows that the roughness of the workpiece is lower compare to the CMFO, besides that the Wear scar observation also shows CMFO has a lot of wear on workpiece surface.
Structural, morphological, magnetic and electrical properties of Ni-doped ZnO nanoparticles synthesized by co-precipitation method

Weak ferromagnetic behaviour was obtained in a systematic way at room temperature by doping of ZnO with nickel (Zn1-xNixO, where x = 0.00, 0.05, 0.15 and 0.20). The obtained results were correlated with conductivity and impedance studies. Diamagnetic to ferromagnetic change was observed with increased concentration of nickel. X-ray diffraction analysis confirmed wurtzite ZnO structure of prepared nanopowders while microstrain was increased with nickel concentration. Incorporation of nickel in ZnO structure was confirmed using EDAX analysis, while FTIR spectroscopy provided further information on functional groups. Transmission electron microscopy images showed that the particle sizes are in the range of 12–20 nm, and scanning electron microscopy analyses that grain size decreases with increase in nickel concentration. Photo luminescence studies confirmed the presence of VO and Zni defects in the prepared samples. It was concluded that the defect induced strain, grain boundaries and lower particle sizes are the reasons for weak ferromagnetic behaviour of the investigated samples.
Automatically Extracting and Aggregating Events From Text

Measuring what political actors do in the world at the core of empirical social science, but existing automated methods to extract actions and behavior from text are highly specific, innaccurate, or expensive to build. This paper introduces a method for automatically extracting political events from text that uses syntactic information provided by natural language processing tools and neural networks trained on a diverse set of hand-labeled text. The method treats event extraction as a “slot filling” task, identifying the words in text that report who is doing what to whom, where and when, as reported by whom? In contrast to previous methods, this method not require hand-constructed dictionaries or pre-specified ontologies. To aggregate extracted actions into useful clusters, I introduce a new short text clustering algorithm that uses word embeddings to provide prior information. I illustrate the method by extracting one million events reported in State Department annual human rights reports and find that the types of abuses and specificity of reporting have changed over time.
Comparative analyses on the chemical compostion, phytochemcimal and antioxidant properties of selected milled varieties (finger and pearl millet)

Purpose: Millet is a major food source in the arid and semi-arid parts of the world especially among people with low socio-economic status. It is a good source of energy, protein, minerals, dietary Fibre, fatty acid, amino acid (especially sulphur containing amino acid), phytochemicals and a good source of antioxidant. Methods: The millet varieties were obtained from the central market in Katsina state, Nigeria. The millet varieties (finger and pearl millet) were cleaned by washing in water, de-watered, sun dried, milled into flour and stored in sealed polythene bags. Standard method were used to determine the phytochemical, atomic absorption spectrometer, amino acid profile was determined spectrometically using a gas chromatography (GC), antioxidant property was measured by determination of free radical scavenging ability (DPPH,FRAP and ABTS) and data was analyzed by one way analysis of variance (ANOVA) using SPSS (16.0) software. The result obtained from studied millet varieties showed the fatty acid profile contain more than 70% unsaturated fatty acid. Amino acid profile showed the presence of essential amino acid of nutritional importance (especially the sulphur containing amino acids). Results: The results obtained from the studied millet varieties showed a protein content level within the range of (10.09%-10.85%), fat content level between the range (2.76%-4.43%), carbohydrate, fat and ash content between the range (71.56% - 73.18%), (2.23% - 3.24%) and (0.86% - 1.94%) respectively. The mineral composition showed it contained mineral elements of health importance, such as; phosphorus, calcium, potassium, sodium and magnesium as well as other minor elements such as copper, manganese, zinc and iron. Phytochemical analyses showed the presence of plant chemical such as; tannin, terpenoid, alkaloid, cardiac glycoside, saponin, oxalate, phytate, flavonoids and total phenol. Antioxidant analyses showed they possess ability to serve as reducing agent hence a rich source of antioxidant of health importance. Unique contribution to theory, practice and policy: The study revealed a high nutritional quality and possible therapeutic effect of the studied millet varieties which are locally sourced and relatively cheaper source of food for a teeming population like ours.
GROWTH RESPONSES TO SELECTION FOR HIGH BODY WEIGHT IN MEAT LINE OF JAPANESE QUAIL

The main objectives of the present study were to estimate the direct response to individual selection for high body weight at six weeks of age (BW6) with estimated the realized heritability of BW6 from two successive selected generations of this line. Besides that, estimate the correlated responses for other growth traits in meat line of Japanese quail. The results were obtained from this work; the means of body weight at different ages for selected line were higher than for control line with highly significant differences in both selected generations. with respect to generation, the results were shown the heaviest body weight at all different ages in the second generation and the lightest in the base with highly significant differences. The results revealed improving of daily weight gain during different periods for selected line in both selected generations compared control line with significant differences. Among generations, the daily weight gains during all different periods of second selected generation were the highest than the rest of generations with highly significant differences. Direct selection response of BW6 was in the first generation (16.76 g). However, selection response decreases in the second generation (5.97 g). Finally of two selected generations, the body weight at 6 weeks of age increased by 22.73 g. for selected line comparing with control line. Also, the selection for BW6 had positive correlated responses on body weight at hatch, 2 and 4 weeks of ages. The daily weight gains have improved after two generations of BW6 selection by 0.41, 0.67, 0.50 and 0.53 g/d during 0 (hatch) – 2, 2 – 4, 4 6 and 0 – 6 weeks of ages, respectively. It can conclude that the results of selection for high body weight at 6 weeks of age was caused improvement body weight at the same age and also improvements both of body weight at different ages and daily weight gain during different periods of quail growth stage. Moreover, these improvements were higher in the first generation of selection than the second.