Miracle-dz/UniFAR-FTUs huggingface dataset:
[Soluble transferrin receptors: significance and diagnostic value in anemia].

: The study was undertaken for the purpose of demonstrating a diagnostic importance of determining the level of soluble transferrin receptors not only in the diagnosis of iron-deficiency conditions (IDC) or in the differential diagnosis of anemia in a chronic disease (ACD) and of iron-deficiency anemia (IDA) but also in making a diagnosis in case of transfusion-dependent patients with Cooley's anemia. The iron metabolism (including determination of the serum iron (SI), of the total iron-binding ability (TIBA), of saturation of transferrin with iron (STFI), of serum transferrin (ST), and of soluble transferrin receptors (s-STR) was examined in 31 patients with different-genesis anemias, aged 3 to 7. Diagnoses were made for all children on the basis of the standard clinical-and-laboratory examinations and tests. A pattern of iron-metabolism parameters, typical of this pathology, was detected in all IDC patients; it is noteworthy, that the s-STR concentration amounted in this category to 9.4 +/- 1.35 mg/l, which essentially topped the normal values. It can be concluded on the basis of the obtained results that s-STR can be regarded as a key IDC marker. There was an increased SF (up to 324 +/- 64.5 mkg/L) alongside with hypoferremia in the ACD patients; the s-STR content was found to be within the reference values (3.21 +/- 0.55 mg/L), the determination of s-STR can be regarded as a test in the differential diagnosis of IDC and ACD. The results of s-STR research ranged, in patients with Cooley's anemia, drastically from 0.8 mg/L to 17 mg/L; it is noteworthy, that there was a reliable dependence on an adequacy of the conducted therapy in case of such patients. The highest sSTR values were found in children with the hereditary spherocytic hemolytic anemia (11.85 +/- 2.5 mg/L), which is, apparently, explained by a proliferative super-activity of the bone marrow observed in this pathology.
The potential of emerging new therapeutics for the treatment of perivascular epithelioid cell tumors (PEComa)

ABSTRACT Introduction: Perivascular epithelioid cell tumor (PEComa) constitutes a family of rare mesenchymal soft-tissue tumors. These tumors pose a significant diagnostic challenge, given their cytomorphology and characteristic co-expression of both melanocytic and myogenic markers. While most PEComas show benign behavior, a subset of PEComas can act malignantly. Historically, cytotoxic chemotherapy used in other soft-tissue sarcomas has shown little benefit. However, a growing understanding of the role of aberrant mTOR pathway activation in these tumors has yielded multiple reports of durable tumor responses and clinical benefit with mTOR inhibitors such as sirolimus, temsirolimus, and everolimus. Areas covered: We describe the histopathology, molecular features and differential diagnosis of the PEComa family and review available data on treatment strategies for localized and advanced PEComa. A literature search was performed using PubMed, American Society of Clinical Oncology, and ClinicalTrials.gov websites. Expert opinion: mTOR inhibitors are emerging as the standard approach to the management of advanced PEComa. Results of the clinical trial for advanced PEComa with ABI-009, a nanoparticle albumin-bound mTOR inhibitor, will provide the first prospective data of mTOR inhibition in PEComa, and may establish a relationship between genotype and outcome.
Learning styles preferences and e-learning experience of undergraduate dental students

Abstract Introduction Education in the health sciences has been undergoing profound changes due to the incorporation of information and communication technologies. Students learn through a variety of approaches, according to their learning styles. Blended learning, which combines technology-aided learning (e-learning) with traditional face-to-face teaching methods, has been found to improve learning outcomes. Objective The aims of the present study were to evaluate the learning styles of undergraduate dental students and their experience towards the use of e-learning. Material and method Two electronic questionnaires were sent to 174 students. The learning styles were determined by the Felder & Soloman Index (ILS), which evaluates the following four dimensions of learning: processing information (active-reflexive); perceiving information (sensorial-intuitive); receiving information (visual-verbal); and understanding information (sequential-global). To determine the e-learning experience we used four questions (Likert scale – five-point) which addressed the experience and the use of information and communication technologies. Result Most students presented a well-balanced style for the active-reflective (60%) and sequential-global (68%) domains. The sensing style (64%) was predominant. A lower percentage presented a global characteristic (9%). We did not find significant differences regarding the age groups (19-21 and 22-33 years) and genders (P>0.05, χ 2). However, in terms of age the difference was significant concerning websites helping in learning (P=0.0363, Mann-Whitney). Conclusion We conclude that the students do not have the same learning styles and e-learning experience. Methods such as blended learning could provide advantages when teaching undergraduate dental students.
Overview of physiological and pathophysiological effects of thromboxane A2.

: Thromboxane (Tx) A2 is a biologically potent and chemically unstable metabolite of prostaglandin endoperoxides. Recent developments in measurement techniques and the availability of both selective inhibitors of Tx synthetase and TxA2 receptor antagonists have facilitated the implication of TxA2 as a physiological modulator and as a mediator in thrombotic, vasospastic, and bronchospastic conditions. TxA2 is synthesized by platelets and contributes to platelet activation and irreversible platelet aggregation in physiological hemostasis and in thrombosis (e.g., unstable angina, stroke). TxA2 is also synthesized in intestinal, pulmonary, and renal tissues by cells other than platelets. Particularly in these tissues, TxA2 appears to act as a physiological modulator of changes in blood flow distribution and airway caliber. Strong stimuli for TxA2 release from these tissues may initiate ulcer, pulmonary hypertension, bronchoconstriction, and renal vasoconstriction. Evidence supports participation of TxA2 and/or TxA2 receptors in modulation of natural cytotoxic cell cytotoxicity, in tumor growth and metastasis, in complications of pregnancy (e.g., preeclampsia), and in the progression of ischemic injury after coronary artery occlusion. This evidence supports pivotal involvement of TxA2 in pathophysiology and provides a strong rationale for pursuing TxA2-blocking strategies in drug development.
The role of arginine 244 in Candida glabrata tRNA nucleotidyltransferase

The enzyme ATP(CTP):tRNA nucleotidyltransferase is essential in eukaryotes to allow tRNAs to participate in protein synthesis. It adds a specific cytidine-cytidine-adenosine (CCA) sequence to generate positions 74, 75, and 76 at the 3' ends of tRNAs in a nucleic acid template-independent manner. Considerable effort has gone into exploring the catalytic mechanism of this enzyme and several bacterial forms, as well as the human enzyme, have been crystallized either in the presence or absence of substrates. Here, we will discuss the role of an essential conserved arginine in a novel attempt to link in vitro enzyme activity to a measurable in vivo phenotype. We found that changing arginine 244 in Candida glabrata tRNA nucleotidyltransferase to alanine, lysine, or methionine resulted in cell death, even though the variant enzymes showed 50-70% activity as compared to the wild-type enzyme under standard in vitro assay conditions using a mixed population of tRNAs as substrate. More specific assays monitoring the incorporation of nucleotides into tRNA with known 3' ends demonstrated a loss of nucleotide addition at position 74, a reduction of nucleotide specificity at position 75, and an increase in nucleotide specificity at position 76 as compared to the native enzyme. These results suggest that arginine 244 in C. glabrata tRNA nucleotidyltransferase plays a role not only in binding and orienting the substrates (nucleotide triphosphates and tRNA) for catalysis but also in excluding ATP from the active site prior to nucleotide addition to positions 74 and 75.
Improvement in seed germination of Myrica esculenta Buch.-Ham. ex D. Don - a high value tree species of Kumaun Himalaya, India.

The paper describes various experiments carried out to break the dormancy, improve germination ability and reduce the mean germination time (MGT). Germination ability of seeds from different sources (population) were compared to determine the effect of source environment. However, results revealed no significant variation in germination among sources. Compared to control, most of the pretreatments improved percent germination. The imbibed seeds prechilled at 4°C for 20 days showed best (48.6%) response. Significant reduction of MGT and substantial improvement in germination (MGT 28.6 d; Germination 42.1%) was, however, observed for 100 ppm GA 3 (in scarified seeds) pretreatment. Considering practical feasibility and cost effectiveness, the mechanical scarification at micropyle end (MGT-31.6 d; mean germination 40.0%) was recommended as one of the best options especially for rural inhabitants. An attempt has been made to identify various attributes contributing toward seed germination responses in Myrica esculenta. The physical dormancy caused by an impermeable seed coat appears to be the main reason of poor germination.
Falls in Older Adults with Type II Diabetes

Neira Alvarez M1, López-Doriga Bonnardeaux P2, Thuisard I3, Sanz-Rosa D4, Andreu Vazquez C4, Molano Ortiz C1, Arias Muñana E1, Bielza Galindo R1, Gomez Cerezo JF5 1Department of Geriatrics, University Hospital Infanta Sofía, Sebastián de Los Reyes, Madrid, Spain 2Departament of Geriatrics, University Hospital de Getafe, Getafe, Madrid, Spain 3Pharmacy and Biotechnology Department, School of Biomedical Sciences, European University of Madrid, Madrid, Spain 4Clinical Department, School of Biomedical Sciences, European University of Madrid, Madrid, Spain 5Department of Internal Medicine and Geriatrics, University Hospital Infanta Sofía, Sebastián de Los Reyes, Madrid, Spain
A review of clinical experience with progesterone-only injectable contraceptives at OAUTHC, Ile-Ife

Background: Progestogen-only injectable contraceptives (POICs) remain the most popular contraceptive method in Nigeria. Considering how widely used POICs are worldwide, there is little published evidence of their safety and effectiveness. There is also a paucity of research to determine associations between the influence of age and parity and the preferred choice of POICs in women. Aim: This study was to determine the use prevalence and the influence of age and parity on the preferred choice of POIC, and also the reasons for discontinuation among users of POICs at the family planning clinics of OAUTHC, Ile-Ife. Materials and Methods: A retrospective record of 324 women who chose POICs out of a total of 1,029 clients seen at the family planning units of the hospital was collected for the period between January and December 2015. Information relevant to this study objectives was extracted using a purpose-designed proforma. Data were analyzed with SPSS version 16, and results were presented as frequencies and percentages. Pearson Chi-square test was used as test of significance where applicable and a P value < 0.05 was considered statistically significant. Results: The prevalence of POIC during the study period was 31.49%. Depo-Provera (depot medroxyprogesterone acetate [DMPA]) was the most popular injectable preferred by the women. Age and parity had significant effects on the preferred injectable contraception with P values of 0.032 (CI 0.088-0.099) and 0.002 (CI 0.009-0.013), respectively, as younger clients with lower parity preferred Noristerat while preference for DMPA increased with age and parity. Majority (67%) did not experience any side effect; secondary amenorrhea was the most common side effect experienced by 27% of the clients. Only 34% continued with the method for the duration of study while 66% discontinued for different reasons. Conclusion: POICs are very effective and safe long-acting reversible method of contraception. While DMPA may be the more popular overall choice, norethisterone enanthate (NET-EN) is preferable in younger women of low parity.
Hubungan Kebiasaan Mencuci Tangan, Kebiasaan Mandi dan Sumber Air Dengan Kejadian Diare pada Balita di Wilayah Kerja Puskesmas 4 Ulu Kecamatan Seberang Ulu I Palembang

Meningkatnya kejadian diare diduga karena adanya ketimpangan kebiasaan higienis pribadi atau Prilaku Hidup Bersih dan Sehat. Tujuan dari penelitian ini adalah untuk menganalisis apakah ada hubungan antara kebiasaan mencuci tangan, kebiasaan mandi dan sumber air dengan kejadian diare pada anak balita di Wilayah kerja Puskesmas 4 Ulu Kecamatan Seberang Ulu I Palembang. Metode penelitian dalam bentuk kuantitatif yang bersifat observasional dengan metode pendekatan kasus kontrol, jumlah sampel sebanyak 120 orang dimana terdiri dari 60 kelompok kasus dan 60 kelompok kontrol diambil dengan cara aksidental. Hasil penelitian menunjukkan bahwa ada hubungan signifikan antar kebiasaan mencuci tangan, kebiasaan mandi, sumber air, dan pendidikan ibu dengan kejadian diare dengan nilai p value < 0,05. Analisis multivariat menunjukkan variabel dominan yang memberikan pengaruh secara signifikan terhadap kejadian diare adalah kebiasaan mencuci tangan, sumber air dan pendidikan ibu. Perlunya pendidikan kesehatan mengenai pada ibu mengenai kebiasaan mencuci tangan menggunakan sabun, dan penggunaan air bersih yang memenuhi syarat dalam kebutuhan sehar-hari, sehingga dapat menurunkan kejadian diare.
Monitoring of reading and spelling in glioma patients undergoing awake surgery

One of the main aims of awake surgery for glioma patients is to preserve quality of life, while maximizing tumor resection. Focusing on an important yet understudied aspect of quality of life, this thesis investigates to what extent written language may be affected by a glioma or glioma surgery. By reviewing current assessments of reading and spelling in awake surgery studies, we aimed to provide a better understanding of how neuroanatomical theories may guide neurosurgical practice, and to evaluate how examinations of written language in glioma patients can be improved. To provide a direct clinical application for this knowledge, we developed a theory-driven written language battery specifically for glioma patients. Lastly, we tested its efficacy and evaluated reading and spelling performance in neurosurgical practice. The studies in this thesis have provided a better understanding of written language in neurosurgical practice. In particular, it has contributed to prediction and prevention of written language disorders in glioma patients undergoing awake surgery, and it has resulted in a valid examination tool to carefully monitor reading and spelling in this patient group.
Assessment of macular and peripapillary choroidal thickness in non-arteritic anterior ischemic optic neuropathy: A meta-analysis

Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common optic neuropathy in adults aged ≥ 50 years. Transient non-perfusion or hypoperfusion of the optic nerve head circulation is believed to be the underlying cause of NAION. It has been suggested that peripapillary choroidal thickness (PCT) is altered after ischemic disorders of the optic nerve head, but the results have not always been consistent. To address this issue and provide evidence for the pathogenesis of NAION, we performed a meta-analysis to systematically evaluate macular choroidal thickness (MCT) and PCT in patients with NAION. Methods: A comprehensive literature search of PubMed, Embase, Cochrane Library, and Web of Science databases was performed until August 31, 2022. The main inclusion criterion was a case-control study in which MCT and PCT were measured using optical coherence tomography in patients with NAION. Mean difference (MD) and 95% confidence interval were calculated for continuous estimates. The Review Manager (V5.40) was used for the analysis. Results: Nine studies comprising 663 eyes (283 NAION eyes and 380 healthy control eyes) were included (Newcastle-Ottawa Scale score ≥ 5). MCT and PCT were higher in eyes with chronic NAION (MD = 19.16, P = .04; MD = 35.36, P < .00001) and NAION fellow eyes (MD = 30.35, P = .0006; MD = 29.86, P = .04) than in healthy controls. No difference was noted in the MCT between eyes with acute NAION and healthy controls (MD = 2.99, P = .87). Conclusion: Increased MCT and PCT may be important anatomical and physiological features of the eyes in patients with NAION.
Fatal Drowning in Brazilian Toddlers and Preschoolers in the City of Campina Grande

Abstract Drowning is one of the accidents with the greatest impact on health. The objective of this paper was to analyze drowning deaths involving children up to four years of age in Campina Grande, Brazil. A cross-sectional study was developed using secondary data, carried out at the Forensic Medicine Unit. All autopsy reports of children 0-4 years of age, victims of drowning in the period from 2008 to 2011 were evaluated. Data referring to the year of occurrence, victims’ gender and age, time of day, day of week and place of occurrence were collected. Data analysis involved descriptive statistics (frequency distribution). Ninety-three cases of fatal drowning were identified, of which 20 (21.5%) involved children under four years of age. Most victims were male (80%), aged one year (35%). The accidents occurred predominantly during the day (85%), mostly at home (75%). The drowning victims were mostly boys in the first year of life and most cases of drowning occurred at their homes.
Sub muscular bridge plating for pediatric femur fractures – Review of 12 patients

Introduction: The treatment of paediatric femoral fractures has been evolving from nonoperative modalities to operative intervention, especially in older children. Different methods of fixation include flexible intramedullary nailing, modified locked intramedullary nailing, external fixation, open compression plating, and sub muscular bridge plating. Treatment of complex paediatric femur diaphyseal fractures is difficult by conventional methods. External fixation can lead to malalignment and refractures, casting is difficult for polytrauma patients and larger children, elastic nails do not provide adequate stability to unstable fractures and metaphyseal areas, and lateral trochanteric entry rigid nails are unsuitable for very proximal and distal fragments and are ideal for older children for the want of larger medullary canal. Sub muscular bridge plating has emerged as a viable alternative procedure. We present our results of sub muscular bridge plating in 12 patients. Materials and Methods: We retrospectively reviewed 12 patients with pediatric diaphyseal femoral fractures treated with SBP from 2014 to 2016. The average age was 9 years with follow up of 1yr. Results: All the children had complete union and could return to full activity. Two patients had superficial infections. There were no cases of significant malalignment or leg length discrepancy. Implant removal was performed in 8 patients without complications. Conclusion: We find sub muscular plating of paediatric femoral fractures to be an effective and reliable procedure. SBP is a minimally invasive technique that allows early mobilization with minimal complications.
First Human Experience With Pulmonary Vein Isolation Using a Through-the-Balloon Circumferential Ultrasound Ablation System for Recurrent Atrial Fibrillation

Background—Standard mapping and ablation of focal sources of atrial fibrillation are associated with very long procedure times and low efficacy. An anatomic approach to complete pulmonary vein isolation could overcome these limitations. Methods and Results—Fifteen patients with atrial fibrillation refractory to medication underwent circumferential isolation of the pulmonary veins by using a novel catheter, with an ultrasound transducer (8-MHz) mounted near the tip, in a saline-filled balloon. Twelve atrial foci and/or atrial fibrillation triggers were identified in 9 patients (pulmonary vein locations: left upper, 3; right upper, 6; right middle, 1; right lower, 1; and left inferior, 1). In 5 patients, lesions were placed in the absence of any mapped triggers. Irrespective of trigger mapping, circumferential isolation of both upper pulmonary veins was attempted in all patients. The lower pulmonary veins were ablated when sinus rhythm activation mapping revealed evidence of a sleeve of atrial muscle in the.
Quality of life of ostomized person: relationship with the care provided in stomatherapy nursing consultation

Abstract Objective: To analyze the relationship between the Quality of Life (QoL) and the stomatherapy nursing consultation. Method: Descriptive-correlational study with 100 ostomized adult participants, to whom a form was applied. The data were treated with SPSS software version 20.0. Results: Most ostomized (67%) presented a positive perception of QoL. This differed significantly (p < 0.05) between the types of ostomy and previous preparation in the consultation, as the colostomy patients and the individuals who booked the appointment of the stoma previously during the consultation had a better QoL. Conclusions: There is a statistical relationship between QoL, the type of ostomy and the participation in the stomatherapy nursing consultation, demonstrating the positive influence of nursing care for the ostomized. The study reinforces the importance of consultation for the adaptation of ostomized people to the new condition and improvement of their QoL.
Progesterone and 17 β -Estradiol Have No Relationship with Renal Clearance of Creatinine During Normal Pregnancy and The Puerperium

This study was carried out, to determine the association between the steroid hormones concentration increase and creatinine clearance during pregnancy and to make observations on the pattern of change in renal function in the late puerperium. This study included 330 apparently healthy normotensive female subjects, made up of seventy each trimesters of pregnancy with seventy (70) women at six weeks post-partum. Fifty (50) non-pregnant women of child bearing age served as controls. Blood and urine samples were collected from each woman during the first, second and third trimesters of pregnancy and during the late puerperium. Serum and urine creatinine, were determined by colorimetric methods. Serum electrolyte profile was determined by Ion Selective Electrode method using automated machine, while the hormonal assays were done using Elecsys 2010 autoanalyzer. The results of both creatinine clearance and the hormonal assay showed significant increase during pregnancy. However, the correlation analysis did not reveal any significant relationship among groups. There were significant differences in the changes observed in other parameters within the trimesters and the puerperium. The increase in creatinine clearance above the normal level during the postpartum period, despite the rapid clearance of the hormones shows that renal function became more efficient, in order to clear excess fluid and electrolytes that the body accumulated during pregnancy. Therefore, the increase in progesterone and 17β-estradiol may not have direct roles in the increase in creatinine clearance during pregnancy. Relationship, Creatinine clearance, Normal pregnancy, Puerperium