Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Characterization of blaCTX-M, blaTEM and blaSHV Beta Lactamases Produced by Uropathogens

Background: This prospective study was carried out to look for the frequency of isolation of Extended spectrum  lactamase (ESBL) producing bacteria from urine samples and study their susceptibility pattern. The detection of ESBL genes responsible for their resistance was done by Polymerase chain reaction (PCR). Methods: The study was carried out over a period of one year from January 2016 to December 2016. Urine specimens from patients were processed as per standard protocol. Antimicrobial susceptibility testing was performed by disk diffusion method as per CLSI guidelines 2016. Urine isolates obtained were screened for ESBL, by cefotaxime, ceftazidime disk and confirmation Original Research Article Bhasin et al.; JAMMR, 32(23): 97-106, 2020; Article no.JAMMR. 62830 98 was made by Double disk diffusion test method. The detection of ESBL genes responsible for their resistance was done by Polymerase chain reaction (PCR) for blaCTX-M, blaTEM and blaSHV genes. Results: Prevalence of ESBL producing uropathogens were found to be 20.47% with most common organism to be isolated was Escherichia coli (E. coli) followed by Klebsiella pneumoniae. Nitrofurantoin and Imipenem were the most effective antibiotic agents against urinary isolates. Most common gene responsible for ESBL production was blaCTX-M (71.42%). Conclusion: A large number of ESBL producing strains are creating significant therapeutic problems. Therefore, monitoring of ESBL production, judicious use of antibiotics and infection control measures are necessary to avoid treatment failures in patients with Urinary Tract Infections (UTI).
Neuroendocrinology Letters-Neuro Endocrinol Lett

BACKGROUND: Air pollution in ambient air could affect the increase of obesity in children. METHOD: Review analyze papers about the effect of polycyclic aromatic hydrocarbons (PAHs), fine particles (particulate matter < 2.5 μm, PM2.5), and traffic air pollution (NO2, NOx, PM2.5). RESULTS: Prenatal exposure to concentrations 1.73–3.07 ng/m3 PAHs significantly increased obesity at age 5 and 7 years, up to 11 years. All studies indicate the significance of prenatal exposure with concentration > 0.3 ng/m3 of B[a]P (benzo[a]pyrene). Prenatal exposure to PM2.5 above concentrations 10.6–11.9 μg/ m3 increased obesity in children up to the age of 9 years. Traffic air pollution was evaluated according to exposure to NO2 and PM2.5. Concentrations NO2 higher 30 μg/m3 affect adiponectin levels in cord blood, cholesterol metabolism, and therefore increase later the risk of overweight or obesity. PM2.5 9.2–11.6 μg/m3 during pregnancy affect adiponectin. These concentrations from the traffic air pollution can affect the metabolism in newborns later related to obesity. CONCLUSION: All these studies indicate that contemporary concentrations of PAHs, PM2.5 and NO2 in ambient air, especially during prenatal period, affect overweight and obesity in children.
SnO2–CuO nanocomposite thin film sensor for fast detection of H2S gas

SnO2 thin film and SnO2–CuO nanocomposite thin film sensors have been realised by pulsed laser deposition (PLD). The prepared sensor structures have been studied for the sensing response characteristics in the presence of 20 ppm H2S gas. An enhancement in the response was observed from 1.4 × 102 for bare SnO2 thin film sensor to 4.3 × 103 for SnO2–CuO composite sensor with a fast response (t 90) time of about 2 s. The enhanced response has been attributed to the highly porous morphology of the films grown by PLD besides the modulation of space charge region due to spillover of H2S gas molecules on the surface of SnO2 film by the CuO catalyst.
Mycological,biochemical,and histopathological studies on fungal disease on cultured clarias gariepinus

A total fifty diseased cat fish (Clarias gariepinus) were collected from private fish farms in Dakahlia governorate which suffered from cumulative mortality. All collected fish were subjected to clinical, postmortem, histopathological and mycological examination. Aflatoxins were extracted and quantitated from feed and musculature of infected fish using HPLC, blood samples were collected for biochemical and haematological parameters. The clinical observation revealed that the infected fish showed opacity of the eyes, yellowish greenish gills, hemorrhagic and yellowish skin, and the fish were slow in motion.The postmortem examination showed enlargement of the gall bladder,distention of the stomach,yellowish enlarged liver and the kidneys were swollen, dark red and friable whereas, the histopathological examination revealed a severe degenerative and necrotic changes in most internal organs. On the other hand Mycological examination of infected fish yeilded isolation of Aspergillus flavus (42%), A.parasiticus (34.8%) , A.niger (12%) and A.fumigatus (10.9%). The mean levels of aflatoxins in feed was 108.9 ppb(46.4 ppb AFB1,1.5ppb AFB2,58.9 ppb AFG1,2.1ppbAFG2),while the mean of AFs residues detected in musculature was 2o.8ppb(11.3,0.15,8.9,0.5ppb)respectively.Regarding to biochemical and hematological parameters, there was a significant decrease in serum Albumin and significant increase in AST,ALT and serum creatinine of infected fish which indicated liver and kidney damage.Also, there was significant decrease in Hb concentration and RBCs count whish indicated the high toxic effect of aflatoxins.
GAUGED COTANGENT BUNDLE REDUCTION WITH SINGULARITIES

This article surveys in a non-technical way the current status of the theory of symplectic and Poisson reduction of cotangent lifted Lie group actions exhibiting singularities. We explain how the involved singular spaces obtained through several reduction processes can be globally realized as stratified fiber bundles, where each of the strata is a smooth bundle that can be identified with the reduced space obtained via some classical reduction scheme for a cotangent lifted action where the singularities have been essentially removed.
The Determinants of Corporate Cash Holding in Indonesia: Manufacturing Company

This research has the purpose of analyzing the cash flow, capital expenditures, liquid assets, tangible assets, bank debt, firm size, research and development, growth opportunities, leverage, cash flow volatility, managerial ownership toward cash holding. The population in this research are all manufacturing firms listed on the Indonesia Stock Exchange (IDX). The sampling technique uses a purposive sampling method, and 78 observations have obtained from 26 companies for the 2016-2018 period. The method used in this research is quantitative. The results of this study indicate that liquid assets, tangible assets, and leverage have significant impact on cash holdings. In contrast, cash flow, bank debt, capital expenditure, firm size, research and development, growth opportunities, cash flow volatility, and managerial ownership do not have significant impact on cash holding.
Measurement and prediction of the elongational stress growth in a dilute solution of DNA molecules

We report the measurement of the elongational stress growth coefficient of a dilute solution of λ-phage DNA molecules in sugar and corn-syrup solvent mixtures under excess salt conditions. The stress growth is measured using a filament stretching rheometer, at strain rates far exceeding the inverse relaxation time of the DNA molecule. The DNA molecule is assumed to behave like a long chain polymer molecule under good solvent conditions, and the observed behavior is modeled using a bead-spring chain model for the DNA. Excluded-volume (EV) effects are accounted for by a narrow-Gaussian repulsive potential between the beads, hydrodynamic interactions (HI) between beads are approximated by the Rotne-Prager-Yamakawa tensor, and the finite length of the DNA molecule is treated by springs whose force-extension behavior mimics that of a wormlike chain. By combining a Brownian dynamics simulation of the chain along with the recently introduced method of successive fine graining [Sunthar, P.; Prakash, J. R. Macromolecules 2005, 38, 617], predictions of the stress growth coefficient are obtained which are insensitive to the microscopic interaction parameters for EV and HI.
Density Functional Theory and Electron Paramagnetic Resonance Study on the Effect of N−F Codoping of TiO2

Recent experiments have indicated that titanium dioxide (TiO2) codoped with nitrogen and fluorine may show enhanced photocatalytic activity in the visible region with respect to TiO2 doped only with nitrogen. Prompted by these findings, we have investigated N−F codoped TiO2 through a combined theoretical and experimental study. Density functional theory (DFT) calculations have been carried out both within the generalized gradient approximation (GGA) and using hybrid functionals to accurately describe the electronic structure; substitutional as well as interstitial locations of nitrogen in the TiO2 lattice were considered. From these calculations we infer that N−F codoping reduces the energy cost of doping and also the amount of defects (number of oxygen vacancies) in the lattice, as a consequence of the charge compensation between the nitrogen (p-dopant) and the fluorine (n-dopant) impurities. The UV−visible spectra of the sol−gel prepared TiO2 powders confirm the synergistic effect of N−F codoping: more .
Psychometric properties of the Korean version of the positive aspects of caregiving scale for family caregivers of people with amyotrophic lateral sclerosis

Abstract Objective Many caregivers report finding positive meanings in their caregiving roles and activities. The positive aspects of caregiving (PAC) scale was designed to measure positive appraisals of caregiving. This study assessed the reliability and validity of the Korean version of the PAC for family caregivers of people with amyotrophic lateral sclerosis (ALS). Method The instrument's content and semantic equivalence were established using translation and back translation of the PAC. A convenience sample of 127 family caregivers of patients with ALS in Korea was recruited. Content, construct, and convergent validity of the Korean PAC were evaluated. Cronbach's α was used to assess reliability. This study used secondary data; the primary study received approval from the Institutional Review Board of H Hospital, from where data were collected. The consent forms did not mention the future use of data. Therefore, we have applied for approval regarding this study's protocol and exemption from informed consent. Results The Cronbach's α was 0.92, and internal consistency was acceptable. Exploratory factor analysis supported the construct validity with a two-factor solution explaining 74.73% of the total variance. Regarding convergent validity, the Korean PAC score negatively correlated with caregiver burden and depression and positively with self-rated health status. We were unable to evaluate the suitability of the suggested structural dimensionality through confirmatory factor analysis. Furthermore, as we used secondary data, we could not assess retest reliability for the evaluation of the scale's stability. Significance of results The Korean PAC was found to be an applicable instrument with satisfactory reliability and validity and suitable for further use as a measure for positive appraisals of caregiving for family caregivers of people with ALS. It may be effective for measuring caregivers’ psychological resources.
Kinetics and Mechanism of Fixation of Cu-Cr-As Wood Preservatives. Part V. Effect of Wood Species and Preservative Composition on the Leaching during Storage

Kutscha, N. P. 1968. Cell wall development in normal and compression wood of balsam fir, Abies balsamea (L.) Mill. Ph. D. Dissertation. New York State College of Forestry, Syracuse. Kutscha, N. P. and J. R. Gray. 1970. The potential of lignin research. Tech. Bull. 41. Life Sciences and Agriculture Experiment Station, University of Maine, Orono. Kutscha, N. P. and J. R. Gray. 1972. The suitability of certain stains for studying lignification in balsam fir, Abies balsamea (L.) Mill. Tech. Bull. 53. Life Sciences and Agriculture Experiment Station, University of Maine, Orono. Kutscha, N. P. and R. R. McOrmond. 1972. The suitability of using fluorescence microscopy for studying lignification in balsam fir. Tech. Bull. 62. Life Sciences and Agriculture Experiment Station, University of Maine, Orono. Mann, P. T. 1972. Ray parenchyma cell wall ultrastructure and formation in Pinus banksiana and Pinus strobus. Ph. D. Dissertation. New York State College of Forestry, Syracuse. Murmanis, L. and I. Sachs. 1969. Structure of pit border in Pinus strobus (L.). Wood and Fiber ( ), 7—17. Saleh, T. M. , L. Leney and K. V. Sarkanen. 1967. Radioautographic studies of cottonwood, Douglas fir, and wheat plants. Holzforschung 21, 116—120. Schwarzmann, J. M. 1973. The sequence of lignification in normal wood of balsam fir, Abies balsamea (L.) Mill. M. S. Thesis. University of Maine, Orono. Schwarzmann, J. M. and N. P. Kutscha. 1973. Preliminary observations on lignification in tracheids of balsam fir. In: C. J. Arceneaux , Ed., Proc., Electron microscopy society of America. Claitor's Publishing Division, New Orleans, p. 464. Scurfield, G. 1967. Histochemistry of reaction wood differentiation in Pinus radiata D. Don. Austral. J. Bot. 18, 377—392. Wardrop, A. B. 1957. The phase of lignification in the differentiation of wood fibers. Tappi 40 (4), 225—243.
Searching for Gambles: Investor Attention, Gambling Sentiment, and Stock Market Outcomes

This paper shows that changes in gambling attitudes affect asset prices and corporate decisions. Using the Internet search volume for lottery-related keywords to capture gambling sentiment shifts, we show that when the overall gambling sentiment is high, investor demand for lottery-like stocks increases, stocks with lottery-like characteristics earn positive abnormal returns in the short-run, managers are more likely to announce stock splits to cater to the increased demand for low-priced lottery stocks, and IPOs perceived as lotteries earn higher firstday returns. Further, the sentiment-return relation is stronger among low institutional-ownership firms and in regions where gambling is more acceptable. JEL Classification: G11; G12; G14
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes

Central serous chorioretinopathy is characterized by neurosensory detachment of the central retina secondary to fluid leakage through the retinal pigment epithelium. Though it has an incidence of 9,9 per 100.000 in men and 1,7 per 100.000 in women, it is the fourth most common retinal disorder. Central serous chorioretinopathy patients present with blurred vision, central scotoma, metamorphopsia, micropsia and mild color discrimination. It is usually a self-limited disorder with nearly none or minimal visual impairment but in some patients the disease persists and may cause severe visual impairment. Central serous chorioretinopathy pathophysiology is not well understood. Choroid, retinal pigment epithelium and hormonal pathways seem to play important roles in central serous chorioretinopathy pathophysiology. Also, familial cases of the disease indicate that there is a genetic background. The identification of certain disease genes could lead to the development of better diagnostic and therapeutic approaches for central serous chorioretinopathy patients.
the impact of corporate governance structure on the readability of board of directors' report in Egyptian environment

: The main purpose of this study is to investigate the impact of corporate governance structure on the readability of Egyptian board of directors’ reports. The sample includes all EGX100 companies listed from 2013 to 2015, and the study uses multiple regression analysis to test the main hypotheses. Readability level is measured by applying the LIX formula, which suits the Egyptian context. The results demonstrate that board reports for EGX100 companies are complex and hard to read. In addition, four corporate governance variables, namely separation between CEO and chairman roles, number of board of directors’ meetings, foreign board members. and number of audit committee meetings have an impact on the readability level of board reports for EGX100 companies. Further, all control variables except company performance are significantly associated with readability. Greater awareness of the complex style of disclosure reports is crucial for emerging markets to easily convey the required information and enhance communication with stakeholders. Based on the limited literature addressing readability, the current study contributes by investigating the impact of corporate governance structure on readability of corporate board of directors’ reports in an emerging market.
In vitro pH dependent passive transport of ketoprofen and metformin

The kinetics of passive transport of ketoprofen and metformin, as model substances for high and low permeability, respectively, across the artificial membrane under the influence of the pH of donor solution was investigated. There was an upward trend in the apparent permeation coefficient (Papp) of ketoprofen with the decrease in pH to a value close to pKa. At the pH value below pKa the permeation coefficient had lower value, due to the higher retention of ketoprofen in the artificial membrane. Metformin is a low permeable compound, and the highest permeation values were recorded at pH 7.4. Two dissociation constants determine that metformin at physiological pH exists as a hydrophilic cationic molecule, i.e. predominantly in ionized form. At pH values below 2.8, metformin mainly exists in diprotonated form, and it was, thus, very poorly permeable. The highest retention, i.e. affinity of both ketoprofen and metformin to the membrane, was at the lowest pH values, which is explained by different mechanisms. At higher pH values of donor compartment the substances showed significantly less affinity to the membrane. The obtained values of apparent permeation coefficients at studied pH values showed good correlation with the obtained experimental values by other in vitro methods.
A critical discourse analysis of 20 textbooks used in physical education teacher education in Denmark

This article investigates and problematises how contesting discourses about Physical Education (PE) as a school subject are immersed within textbooks used in Physical Education Teacher Education (PETE) in Denmark. The paper considers PETE textbooks as powerful documents that construct and maintain discourses about PE, and at the same time as central texts for the reading of such discourses. Fairclough’s and Foucault’s notions of discourse and discourse analysis are applied to identify dominant patterns in those 20 textbooks that are most used in PETE in Denmark. The findings reveal three different discourses that represent contesting philosophies about the value and practice of PE. These are termed: (1) Developing the potential for sport, (2) Basis for creative sensing and (3) Being part of a cultural ballast. The paper analyses these three discourses critically and concludes that PETE textbooks are deeply involved in the (re)construction, struggling and ‘working’ of classical discourses in PE. The discussion deals with the way that PETE textbooks comprise powerful documents that through their recurrent use of high modality are unequivocal in their suggestions for PE practices, and how pre-service teachers in this way are exposed to antagonistic discourses in PETE textbooks. We suggest that PETE teachers may use textbook analysis in the educational programme as a tool for reflection upon the working of discourses in PE in general and for discussing central ideological dilemmas in PE.
Sterol Constituents from Seven Mushrooms

Six new sterols, 5α, 6α;8α, 9α-diepoxy-(22E, 24R)-ergost-22-ene-3β, 7α-diol (1), 5α, 6α;8α, 9α-diepoxy-(22E, 24R)-ergost-22-ene-3β, 7β-diol (2), 5α, 6α-epoxy-(22E, 24R)-ergosta-8, 22-diene-3β, 7β-diol (3), (22E, 24R)-23-methylergosta-7, 22-diene-3β, 5α, 6β-triol (4), (22E, 24R)-23-methulergosta-7, 22-diene-3β, 5α, 6β, 9α-tetrol (5) and (24S)-ergost-7-ene-3β, 5α, 6β, 9α-tetrol (6), have been isolated from seven mushrooms, Amanita pantherina, Amantia virgineoides, Lactarius piperatus, Lyophyllum shimeji, Tricholoma portentosum, Hypsizigus marmoreus and Lentinula edodes together with eighteen known ones (7-24). The structures of these new compounds were elucidated on the basis of their spectral data.
Rheumatoid arthritis (RA) is a chronic and refractory auto‐ immune joint disease, characterized by the proliferation of synoviocytes in inflamed synovia and the expression of inflammatory cytokines and chemokines in synoviocytes (1). Multiple pro‐inflammatory and inflammatory cytokines

IL‐33 is a member of the IL‐1 family of cytokines whose role remains controversial in rheumatoid arthritis (RA). The present study was performed to evaluate the correlation of IL‐33 with other cytokines and chemokines in serum and the synovia, and to explore the nature of the association. The concentration of IL‐33 in samples from 96 patients with RA was analyzed. The response of fibroblast‐like synoviocytes (FLSs) to treatment with different concentrations of IL‐33 was assessed in vitro. IL‐33 was indicated to exhibit an associa‐ tion with multiple cytokines and chemokines in synovial fluid with an inverted‐U‐shaped trend, including IL‐6, IL‐1β, IL‐8, MIG and IP‐10, but not in the serum. Furthermore, in vitro experiments confirmed that IL‐33 also exerted a U‐type dose‐dependent regulatory effect on FLS function. In addition, the data‐points do not exactly follow the U‐shaped curve fit in most cases, therefore, the applicability of this mathematical model in clinical practice is limited.
Kink effect and noise performance in isolated-gate InAs/AlSb high electron mobility transistors

The kink effect can spoil the otherwise excellent low noise performance of InAs/AlSb high electron mobility transistors. It has its origin in the pile-up of holes (generated by impact ionization) taking place mainly at the drain side of the buffer, which leads to a reduction of the gate-induced channel depletion and results in a drain current enhancement. Our results indicate that the generation of holes by impact ionization and their further recombination lead to fluctuations in the charge of the hole pile-up, which provoke an important increase in the drain current noise, even when the kink effect is hardly perceptible in the output characteristics.
Comparative Evaluation of Five Different Cultivars of Chestnut Flower (Castanea mollissima Blume): Phytonutrient and Chemical Contents, Antioxidant and Anti-tumor Activities

Chestnut flower has been a well-known Chinese traditional medicine to be consumed for clearing heat and intestinal infectious diseases. It is necessary to characterize them in accordance to nutritional value into sources of bioactive nutraceuticals with potential health benefits. The purpose of this study is to obtain the phytonutrient facts, phytochemical antioxidant capacity and antitumor activities from five common Chinese chestnut (Castanea mollissima Blume) flower cultivars. The results obtained exhibit some significant difference among the five cultivars. Zipo genus shows highest total flavonoids contents (85.1 ± 3.6 mgRE/gdm) and protein contents (4.28%), while the one with highest total phenolic content (126.4 ± 0.8 mgGAE/gdm) and total sugar (5.08%) is Yanlong. As for mineral compositions, Zipo genus shows a higher content of Ca, Fe and Cu, while Yanlong outperforms in the content of Zn and Mn. Phytochemical profiling revealed eight compounds belonging to the phenolic acids and flavonoids. Gallic acid and quercetin are the two major compounds of phenolics in all five cultivars. The Chinese chestnut flower cultivars with high phytonutrient content has significantly higher antioxidant and anti-tumor abilities than that of other cultivars. Total flavonoids content and total phenolic content could bring large benefit to antioxidant and anti-tumor activity.