Miracle-dz/UniFAR-FTUs huggingface dataset:
Disposition of mianserin and cyclizine in UGT2B10-overexpressing HEK293 cells: Identification of UGT2B10 as a novel N-glucosidation enzyme and BCRP as an N-glucoside transporter

Reserach Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, Guangzhou, China (D.L., Q.X., B.W.) Shenzhen Key Laboratory for Molecular Biology of Neural Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (D.L.) Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China (D.L., B.W.) International Ocular Surface Research Centre and Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China (D.D., Z.L.) This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on April 24, 2018 as DOI: 10.1124/dmd.118. 080804
A Study of Automated Software Testing: Automation Tools and Frameworks

- The growing demand for delivering quality software faster “Quality at Speed” requires faster and successful execution of software testing to ensure its standard. Utilizing appropriate testing method(s) and right test automation tools/framework are two defining factors for a successful and effective software testing project. Using one testing method will not be sufficient to test software and ensure its standard, a combination of some appropriate testing techniques is often required. Likewise, is no one tool that can satisfy all automated testing needs which makes finding the right tool combination difficult. Knowing the various testing methods and tools/frameworks is the first step towards achieving a successful and efficient software testing. This article presents a comprehensive study of test automation tools and frameworks. Firstly, automated testing and their categories were explained, followed by an explanation of the various test automation frameworks. Finally, a brief explanation and comparison of some of the most commonly used automation tools was presented.
Influence of Culture Conditions on the Length of the Lag Period of Chlorophyll Synthesis in Preilluminated Dark-grown EuglenaI

Two parameters of the potentiation process, the lengths of preillumi- nation and of the subsequent dark phase have been determined for Eaglena ceRs which had been grown in the dark under two different culture conditions. In both cases a maimum potentiation response is obtained after a preillumination period of about 2 hours. The minimum length of the dark period necessary for maximum potentiation changes from 1 hour for cells which contain, at the moment of illumination, a high paramylum content, to 6 hours for cells which have a low paramylum content.
The effects of submaximal exercise training on cardiovascular functions and physical capacity in dogs with myxomatous mitral valve disease

Myxomatous mitral valve disease (MMVD), an important disease in senile small breed dogs, leads to deterioration of cardiovascular function and impairment of functional capacity resulting in poor quality of life. Submaximal treadmill running has been used as both cardiovascular training and testing worldwide in humans and recently in animals. The objectives of this study were to examine the effects of submaximal endurance training (ET) by treadmill running on safety, adverse events, cardiovascular adaptations, hematology, functional capacity, and the feasibility of submaximal treadmill running test and 6-minute walk test (6-MWT) in dogs with MMVD. Six adult beagle dogs with MMVD, stage B1 according to the American College of Veterinary Internal Medicine (ACVIM) guideline, were examined before the study, at weeks 4 and 8 of the ET. The cardiovascular functions assessed by echocardiography and electrocardiography, systolic blood pressure, hematology and blood chemistry profiles, and functional capacity were determined. All dogs completed all tests and ET sessions without clinical complication. ET resulted in significant improvement in physical capacity measured by submaximal treadmill running test and 6-MWT, while cardiac function parameters were not altered. Moreover, serum creatinine was significantly decreased. In conclusion, ET and submaximal exercise tests are clinically feasible. The ET can improve physical capacity in dogs with MMVD, stage B1. Therefore, supervised moderate ET and submaximal exercise tests should be incorporated in MMVD management.
Long-term low-dose erythromycin in patients with unexplained chronic cough: a double-blind placebo controlled trial

Aims Unexplained chronic cough is a common condition with no satisfactory treatments. Previous work has suggested that cough may be linked to neutrophilic airway inﬂammation. This study tested the hypothesis that long-term low-dose erythromycin reduces the induced sputum neutrophil count and 24 h cough frequency in patients with unexplained chronic cough. Methods 30 patients with an unexplained chronic cough lasting more than 8 weeks were randomly assigned to take 250 mg erythromycin once daily (n ¼ 15) or placebo (n ¼ 15) for 12 weeks in a double-blind parallel group study. Cough frequency, cough reﬂex sensitivity and cough severity were assessed at baseline, 6, 12 and 24 weeks. The primary outcome measure was change in 24 h cough frequency at 12 weeks. Results There was no difference in the change in cough frequency between the erythromycin and placebo groups at 12 weeks (mean difference in fold change 1.1; 95% CI 0.7 to 1.5; p ¼ 0.585) or at other times. There was a statistically signiﬁcant between-treatment difference in the change in sputum neutrophils at 12 weeks ( (cid:2) 10.2% vs +6.6% with erythromycin and placebo; mean difference 16.8%; 95% CI 1.6 to 32.1; p ¼ 0.03) but not at other times. There was no difference in the change in other measures of cough between treatments. chronic
On the Detection of Absolute Motion Relative to a Preferred Frame

From the classical perspective, it is well known that the use of the LorentzFitzgerald contraction of bodies in the direction of motion explains the null results reported by Michelson & Morley in their famous experiment (and all successive repetitions). In this paper, using a one-way interferometer and taking into account Lorentz-Fitzgerald contraction, we show that it is possible to detect changes in the interference pattern proportional to the velocity of the interferometer relative to a preferred frame in which light’s speed is ‘c’.
Tilting Modules and their Applications

0. Introduction. 1. Lie algebras and algebraic groups in finite characteristics. 2. Representation of simple algebraic groups. 3. Kempf's vanishing theorem and Weyl character formula. 4. Good filtrations. 5. Canonical Frobenius splittings. 6. Tensor products of good filtrations. 7. Tilting modules. 8. The functor Tr, 9. The Verlinde's Formula and the modular Verlinde's formula. 10. Proof of the modular Verlinde's formula. 11. Tilting modules and commutant algebras. 12. Application of tilting modules to representation theory of GL(V). 13. An easy example: the fusion ring of SL(p1). 14. Application of tilting modules to the symmetric group Sn. 15. Comparison with the quantum case. 16. Appendix: Cohomological criterion for good filtrations.
TNF-a enhances cardiac myocyte NO production through MAP kinase-mediated NF-kB activation

Kan, Hong, Zirong Xie, and Mitchell S. Finkel. TNF-a enhances cardiac myocyte NO production through MAP kinase-mediated NF-kB activation. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1641–H1646, 1999. —We have previously reported that interleukin-1b (IL-1b) alone induced nitric oxide (NO) production by neonatal rat cardiac myocytes (CM). The effects of tumor necrosis factor-a (TNF-a) on inducible NO synthase (iNOS) were not characterized. Unlike IL-1b, TNF-a alone failed to enhance NO production in CM. However, the addition of TNF-a to IL-1b significantly enhanced iNOS mRNA expression, iNOS protein synthesis, and NO production (NO2 ). TNF-a enhancement of IL-1b-induced NO2 2 production was blocked by PD-98059, a selective mitogen-activated protein (MAP) kinase kinase inhibitor, but not calphostin C (Cal C), a protein kinase C inhibitor. TNF-aenhanced MAP kinase activity was associated with an increase in IL-1b-stimulated NF-kB activity. PD-98059, but not Cal C, inhibited both TNF-a-enhanced MAP kinase and NF-kB activities. Thus TNF-a enhancement of IL-1b-induced NO production is associated with MAP kinase-mediated activation of NF-kB.
evaluating THE RELATIONSHIP between corporate profitability and ESG performance with GMM-IV method Short-term financial effects of ESG factors

This study aims to find the answer to the question how the ESG performance of the companies in the MSCI ACWI Index affects short-term profitability. The dependent variables of the analysis are the return on sales and the ROC/WACC ratio measuring added value. The ESG scores are the S&P Global SAM ratings. As the goal of the study is to assess the short-term effects, the 2019 profitability-ESG relation is examined along with several control variables. In studies analysing sustainability, measurement, specification errors and endogeneity are frequent which we manage by applying GMM procedure with robust instrumental variables. Based on our calculations, the relationship between financial and ESG performance is mostly neutral in the specific industries, which may help the achievement of the sustainable development goals of the United Nations in the long run. JEL codes: G32, G34, Q51, Q56, C36, C58
Deletionofthe elongation factor4gene (lepA) inStreptomyces coelicolor enhances theproductionofthe calcium-dependent antibiotic

Elongation factor 4 is a widely distributed translational GTPase also known as LepA. Its physiological role is ambiguous, as only a few phenotypes resulting from lepA null mutations have been reported. Here, we report that a Streptomyces coelicolor lepA null mutant overproduces the calcium-dependent antibiotic (CDA). Our findings are the first that connect LepA (encoded by SCO2562) to antibiotic production. They lend additional evidence that perturbations in the quaternary structure and function of the ribosome can positively affect antibiotic production in Streptomyces bacteria.
DMSO_A_286081 5037..5047

1SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa; 2Division of Chemical Pathology, Faculty of Health Sciences, National Health Laboratory Service (NHLS) and University of Stellenbosch, Cape Town, South Africa; 3NonCommunicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; 4Department of Medicine, University of Cape Town, Cape Town, South Africa Background: microRNAs (miRNAs) have been touted as potential diagnostic and prognostic biomarkers for various diseases. The aim of the present study was to evaluate the diagnostic value of miR-30a-5p and miR-182-5p for prediabetes and screen-detected type 2 diabetes mellitus (T2DM). Methods: The study included 1270 participants (207 prediabetes, 94 screen-detected diabetes and 969 normotolerant) from the Vascular and Metabolic Health (VMH) study. Whole blood levels of miR-30a-5p and miR-182-5p were quantitated by RT-qPCR. Multivariable logistic regressions were used to relate miRNAs with prediabetes or T2DM and receiver operating characteristic (ROC) curves were used to evaluate the ability of each miRNA to diagnose these conditions. Results: Both miRNAs were significantly highly expressed in individuals with prediabetes or T2DM (both ≥3.2-fold, and p<0.001). We also observed significant under-expression in T2DM relative to prediabetes for miR-182-5p (0.49-fold, p=0.001). Age, sex and BMIadjusted partial correlation coefficient analysis revealed a significant correlation between the two miRNAs across glucose tolerance statuses (r≥0.932, p<0.001). In normotolerant individuals, both miRNAs showed a negative correlation with waist circumference and positive correlation with HDL-cholesterol whilst in T2DM they correlated positively with hip circumference, 2-hour insulin, HDLand LDL-cholesterol. Multivariable logistic regressions revealed both miRNAs to be consistently and continuously associated with prediabetes or T2DM (OR≥1.18, 95% 95% CI: 1.10–1.28, p<0.001), while only miR-182-5p associated with a reduced prevalence of T2DM relative to prediabetes (OR: 0.89, 95% CI: 0.83–0.96, p=0.003). In ROC analyses, miR-182-5p almost outperformed HbA1c in diagnosing prediabetes; area under the curve 0.74 vs 0.69. Conclusion: Our findings demonstrate that miR-30a-5p and miR-182-5p are associated with dysglycaemia and could potentially predict prediabetes, particularly miR-182-5p.
University of Birmingham Finite element simulation of the structural integrity of endothelial cell monolayers

Cell extravasation is a crucial step of the metastatic cascade. In this process, the circulating tumor cells inside the blood vessels adhere to the cell monolayer of the blood vessel wall and passes through it, which allows them to invade different organs and complete metastasis. In this process, it is relevant to understand how the adhesions between cells that form the endothelial monolayer are broken, resulting in intra-cellular gaps through which tumor cells are able to extravasate the blood vessel wall. Within this process, we focus on studying the dynamics of cell-cell junctions rupture produced in the endothelial monolayer by the effect of Calcium waves. The regulation of this monolayer is of vital importance, not only in metastasis, but also in diseases such as pulmonary edema or atherosclerosis. In order to understand this rupture dynamics in greater depth, we propose a hybrid model that simulates endothelial cells as an elastic material and cellcell adhesions of the monolayer by means of a catch bond law. We study the effects that the cell contraction caused by a Calcium wave presents on the endothelial monolayer depending on the diameter of the blood vessel. For this purpose, we develop a three-dimensional model to study the effect of the different blood vessel diameters. The results indicate that there are greater tractions on the joints located in vertices common to several cells. This led to the formation of openings in the endothelial monolayer, through which extravasation of tumor cells could occur. For the different geometries studied, no significant effect of the blood Preprint submitted to Engineering Fracture Mechanics December 2, 2019 ar X iv :1 91 1. 13 03 5v 1 [ qbi o. T O ] 2 9 N ov 2 01 9 vessel diameter on the rupture of the adhesions of monolayer is observed.
University of Birmingham Australia Cretaceous Climate and Tectonics

The tectonic and paleoceanographic setting of the Great Australian Bight (GAB) and the Mentelle Basin (MB; adjacent to Naturaliste Plateau) offered an outstanding opportunity to investigate Cretaceous and Cenozoic climate change and ocean dynamics during the last phase of breakup among remnant Gondwana continents. Sediment recovered from sites in both regions during International Ocean Discovery Program Expedition 369 will provide a new perspective on Earth’s temperature variation at sub-polar latitudes (60°–62°S) across the extremes of the mid-Cretaceous hot greenhouse climate and the cooling that followed. The primary goals of the expedition were to samples were taken from each core. Overall, the MAD results show that bulk density increases and grain density and porosity decrease. Bulk density for the dark silty claystone is 1.54–2.37 g/cm 3 , and the density of the sideritic sandstone intervals ranges from 3.21 to 3.49 g/cm 3 . Po-rosities in the silty claystone are 28%–65%, with most measurements between 40% and 48%. The porosity of the sideritic sandstone ranges from 5% to 13%.
Clownfishes evolution below and above the species level

Electronic supplementary material is available online at https://dx.doi. org/10.6084/m9. figshare.c. 3997359. & 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Clownfishes evolution below and above the species level
AttentionBased Deep Feature Fusion for the Scene Classification of HighResolution Remote Sensing Images

Scene classification of highresolution remote sensing images (HRRSI) is one of the most important means of landcover classification. Deep learning techniques, especially the convolutional neural network (CNN) have been widely applied to the scene classification of HRRSI due to the advancement of graphic processing units (GPU). However, they tend to extract features from the whole images rather than discriminative regions. The visual attention mechanism can force the CNN to focus on discriminative regions, but it may suffer from the influence of intraclass diversity and repeated texture. Motivated by these problems, we propose an attention-based deep feature fusion (ADFF) framework that constitutes three parts, namely attention maps generated by Gradientweighted Class Activation Mapping (GradCAM), a multiplicative fusion of deep features and the centerbased cross-entropy loss function. First of all, we propose to make attention maps generated by GradCAM as an explicit input in order to force the network to concentrate on discriminative regions. Then, deep features derived from original images and attention maps are proposed to be fused by multiplicative fusion in order to consider both improved abilities to distinguish scenes of repeated texture and the salient regions. Finally, the centerbased cross-entropy loss function that utilizes both the cross-entropy loss and center loss function is proposed to backpropagate fused features so as to reduce the effect of intraclass diversity on feature representations. The proposed ADFF architecture is tested on three benchmark datasets to show its performance in scene classification. The experiments confirm that the proposed method outperforms most competitive scene classification methods with an average overall accuracy of 94% under different training ratios.
LOCUSS: A DYNAMICAL ANALYSIS OF X-RAY AGN IN LOCAL CLUSTERS

We present a study of the distribution of X-ray AGN in a repres entative sample of 26 massive clusters at 0.15<z<0.30, combiningChandra observations sensitive to X-ray point sources of luminosit y LX∼10 erg s−1 at the cluster redshift with extensive and highly complete s p ctroscopy of cluster members down to ∼MK+2. In total we identify 48 X-ray AGN among the cluster members, wit h luminosities 2×1041−1×1044 erg s−1. Based on these identifications, we estimate that 0 . 73±0.14% of cluster galaxies brighter than MK=−23.1 (M K+1.5) host an X-ray AGN withLX>10 erg s−1. In the stacked caustic diagram that shows ( vlos−<v>)/σv versus rpro j/r500, the X-ray AGN appear to preferentially lie along the causti cs, suggestive of an infalling population. They also appear to avoid the region with lowest cluster-cen tric radii and relative velocities ( rpro j<0.4r500; |v−<v>|/σv<0.8), which is dominated by the virialized population of galax ies accreted earliest into the clusters. The line-of-sight velocity histogram of the X-ray AGN shows a relatively flat distribution, and is inconsistent with the Gaussian distribution expected for a viria lized population at 98.9% confidence. Moreover the velocity dispersion of the 48 X-ray AGN is 1 . 51× that of the overall cluster population, which is consistent with the √ 2 ratio expected by simple energetic arguments when compari ng infalling versus virialized populations. This kinematic segregation is significant at the 4. 66σ level. When splitting the X-ray AGN sample into two according to X-ray or infrared (IR) luminosity, both X-ray b right (LX>10) and IR-bright (LTIR>2×10L⊙) sub-samples show higher velocity dispersions than their Xray dim and IR-dim counterparts at >2σ significance. This is consistent with the nuclear activity respons ible for the X-ray and IR emission being slowly shut down as the host galaxies are accreted into the cluster. Over all our results provide the strongest observational evidence to date that X-ray AGN found in massive clusters are an infalling population, and that the cluster environment very effectively suppresses radiatively-effi cient nuclear activity in its member galaxies. These results are consistent with the view that for galaxies to hos t an X-ray AGN they should be the central galaxy within their dark matter halo and have a ready supply of cold g as. Subject headings: galaxies: active — galaxies: clusters: general — galaxies: evolution — galaxies: stellar content
The educational and technological aspects of the Alternative and Augmentative Communication (AAC)

—AAC is the commonly used abbreviation of the term: Alternative and Augmentative Communication (AAC), which encompasses the different communication methods that can be used to help people with a wide range of speech and language disabilities. We shortly discuss several educational and technological aspects of AAC. We also consider the linguistic issues occurring in the learning and teaching processes of those methods of communication, in particular in conversation with pupils with special communicational needs. The efficiency of such conversation depends, first of all, on the level of acquisition of conversational abilities, but also on the suitable choice of a system of alternative communication (e.g., PCS - Picture Communication Symbols, PIC - Pictogram Ideogram Communi-cation, Sclera Pictograms, MOWiK, Bliss System, Makaton), the proper choice of methods of communication, and the proper selection and use of the technological equipments (e.g., Voice Output Communication Aid, Boardmaker or Boardmaker with Speaking Dynamically Pro). Morever, the persons that teach such commun-ication should be on a high level of self-awareness and posses high qualifications. There are various concerns that the use of AAC might impede their ability to speak using words, but some research records show that this is not the case in general and many applications of AAC facilitate speech production.
University of Birmingham Social cognition and self-other distinctions in neuropsychiatry:

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