Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk-Based Semi-Supervised Discriminative Language Modeling for Broadcast Transcription

SUMMARY This paper describes a new method for semi-supervised discriminative language modeling, which is designed to improve the robustness of a discriminative language model (LM) obtained from manually transcribed (labeled) data. The discriminative LM is implemented as a log-linear model, which employs a set of linguistic features derived from word or phoneme sequences. The proposed semi-supervised discriminative modeling is formulated as a multi-objective optimization programming problem (MOP), which consists of two objective functions defined on both labeled lattices and automatic speech recognition (ASR) lattices as unlabeled data. The objectives are coherently designed based on the expected risks that reflect information about word errors for the training data. The model is trained in a discriminative manner and acquired as a solution to the MOP problem. In transcribing Japanese broadcast programs, the proposed method reduced relatively a word error rate by 6.3% compared with
Meteor , m-bleu and m-ter : Flexible Matching and Parameter Tuning for High-Correlation with Human Judgments of Machine Translation Quality

We describe our submission to the NIST Metrics for Machine Translation Challenge consisting of 4 metrics two versions of meteor, m-bleu and m-ter. We first give a brief description of Meteor . That is followed by descriptino of m-bleu and m-ter, enhanced versions of two other widely used metrics bleu and ter, which extend the exact word matching used in these metrics with the flexible matching based on stemming and Wordnet in Meteor .
Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality control to maintain homeostasis under different conditions and disease states characterized by cell stress. Although three general schemes of and genes induced by UPR are rather well-established, open questions remain including the precise role of UPR in human diseases and the interactions between different sensor systems during cell stress signaling. Particularly, the issue how the normally adaptive and pro-survival UPR pathway turns into a deleterious process causing sustained endoplasmic reticulum (ER) stress and cell death requires more studies. UPR is also named a friend with multiple personalities that we need to understand better to fully recognize its role in normal physiology and in disease pathology. UPR interacts with other organelles including mitochondria, and with cell stress signals and degradation pathways such as autophagy and the ubiquitin proteasome system. Here we review current concepts and mechanisms of UPR as studied in different cells and model systems and highlight the relevance of UPR and related stress signals in various human diseases.
Computation Offloading: Overview, Frameworks and Challenges

In spite of major advances in a mobile cloud computing, applications are still very limited due to poor computation processing power, memory and limited battery life of a mobile device. Recently, offloading computation intensive task to the cloud has become a great solution to improve both battery life and performance of mobile devices. Offloading makes use of quality of services concept to remove mobile application limitations. This paper covers overview, frameworks and challenges of computation offloading.
Spectrofluorimetric determination of flutamide in pharmaceutical preaparations

A simple and reliable spectrofluorimetric method has been developed for the determination of flutamide in the pharmaceutical preparation. The fluorescence of the product was found to have excitation at λ max 255 nm and emission λ emi at 375 nm. The method shows high sensitivity with linearity range from 0.1 to 0.6 µg/ml. The lower limit of detection (LOD) was found to be 1.972 × 10- -3 µg / ml and limit of quantification (LOQ) was found to be 5.975 x 10- -3 µg/ml in formulation. The different experimental parameters affecting the fluorescence intensity were carefully studied and optimized. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed method. The proposed method was applied successfully for determination of flutamide in the pharmaceutical preparation. The percentage recovery was found to be 99.532 ± 0.528.
Span Length Effects on the Progressive Collapse Behaviour in Concrete Structures

Progressive and general collapse of structures are extremely able to cause great casualties and financial losses. Accordingly, evaluation the performance of structures after losing primary elements is of great importance to prevent the structural collapse. This paper presents the progressive collapse assessment of RC moment frames with concrete shear wall system according to different span lengths. First, story column was destroyed by removing its reaction in different scenarios. Then, performance of the structure was evaluated under this circumstance to assess the different span length effects in RC moment frames with concrete shear wall. The results indicated that the shear wall has a positive effect on preventing progressive collapse and reduces the maximum vertical displacement by 30%. It was also observed that maximum Dynamic Amplification Factor (DAF) in the building occurs with the shear wall and the minimum length of the span. However, the maximum Demand Capacity Ratio (DCR) in a critical element for a building was obtained with the longest span and without the shear wall. Therefore, it was concluded that the DCR ratio is more suitable for evaluation of the progressive collapse severity than the DAF parameter.
Individual differences in regulatory focus predict neural response to reward

ABSTRACT Although goal pursuit is related to both functioning of the brain’s reward circuits and psychological factors, the literatures surrounding these concepts have often been separate. Here, we use the psychological construct of regulatory focus to investigate individual differences in neural response to reward. Regulatory focus theory proposes two motivational orientations for personal goal pursuit: (1) promotion, associated with sensitivity to potential gain, and (2) prevention, associated with sensitivity to potential loss. The monetary incentive delay task was used to manipulate reward circuit function, along with instructional framing corresponding to promotion and prevention in a within-subject design. We observed that the more promotion oriented an individual was, the lower their ventral striatum response to gain cues. Follow-up analyses revealed that greater promotion orientation was associated with decreased ventral striatum response even to no-value cues, suggesting that promotion orientation may be associated with relatively hypoactive reward system function. The findings are also likely to represent an interaction between the cognitive and motivational characteristics of the promotion system with the task demands. Prevention orientation did not correlate with ventral striatum response to gain cues, supporting the discriminant validity of regulatory focus theory. The results highlight a dynamic association between individual differences in self-regulation and reward system function.
In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins

An in vitro system was developed that provides a quick microscopic assay for nuclear transport. The assay uses an extract of Xenopus eggs, normal or synthetic nuclei, and a fluorescently labeled nuclear protein, nucleoplasmin. This in vitro system accurately mimics in vivo nuclear transport, both in exclusivity and in the amount of accumulation observed (up to 17-fold). Selective accumulation of fluorescent nucleoplasmin is observed microscopically within 30 min with rat liver nuclei, Xenopus embryonic nuclei, regrown Xenopus sperm nuclei, or nuclei reconstituted in vitro from bacteriophage lambda DNA. This transport requires the signal domain of nucleoplasmin. Furthermore, the ability of nuclei to accumulate nucleoplasmin directly correlates with their ability to exclude the fluorescent non-nuclear proteins, FITC-immunoglobulin and phycoerythrin. An active transport model would predict that nuclear transport be temperature- and energy- dependent and that inhibition of transport by either low temperature or energy depletion would be reversible. Both predictions were confirmed in our system. Nucleoplasmin accumulation increases with temperature, while the protein is completely excluded at 0 degrees C. The effects of low temperature are reversible. As found for 125I-labeled nucleoplasmin (Newmeyer, D. D., J. M. Lucocq, T. R. Burglin, and E. M. De Robertis, 1986, EMBO (Eur. Mol. Biol. Organ.) J., 5:501-510), transport of fluorescent nucleoplasmin is inhibited by ATP depletion. This effect is reversed by later ATP addition. Under ATP-depleted conditions non- nuclear proteins continue to be excluded. These results argue for a direct role of ATP in transport rather than for a simple role in preserving envelope integrity. In a first step towards defining the minimum requirements for a transport medium, egg extracts were depleted of membrane vesicles. Membrane-depleted extracts neither support transport nor maintain the integrity of the nuclear envelope.
Dietary assessment methods used for low-income populations in food consumption surveys: a literature review

In order to assess nutritional adequacy, reliable estimates of nutrient intake are required. Specifically, the EURopean micronutrient RECommendations Aligned (EURRECA) Network of Excellence needs clear guidelines on methods suitable for assessing micronutrient intakes among vulnerable population groups. The objective of this project was to collect, evaluate data and review the suitability of methods used to assess dietary intake of low-income groups across Europe. A comprehensive literature review methodology was employed, which involved structured search MEDLINE, from 1990 to 2008, on (nutrient intake methods) and (validity terms) and (human studies) and finally (low-income terms). In addition, manual searches were conducted for published books and national studies. Seven studies satisfied the selection criteria for inclusion in the review in which four dietary intake methods had been described and validated. Three other studies found in the grey literature used similar methods. Only one study tested a variety of methods to assess reliability and the method preferred by those having low incomes. Preferred methods were 24 h recalls and a FFQ which, compared with the weighed inventory, also yielded higher estimates of energy and nutrient intakes. Many of the methods used in low-income populations have not been subjected to evaluation and consequently may not demonstrate sensitivity and/or specificity when used in this population. Based on one study only, four multiple-pass 24 h recalls are recommended as the most appropriate method for the evaluation of nutritional adequacy in low-income households.
Movement illusions evoked by ensemble cutaneous input from the dorsum of the human hand.

1. In this study we tested the hypothesis that ensemble activity in human cutaneous sensory afferents evoked by the stretching of skin over and around the finger joints contributes to the conscious perception of movement of the fingers. 2. In nineteen normal adults, ensembles of cutaneous afferents were activated either by electrical stimulation, delivered through an array of electrodes on the dorsum of the hand and fingers, or by mechanical stretching of the skin over and around the joints. The stretching was applied through an array of threads stuck to the skin, in such a way as to avoid or minimize moving the underlying joints and to avoid applying pressure to underlying tendons and ligaments. Perceived movements were mimicked by voluntary movements of the fingers of the contralateral hand. 3. By way of comparison, kinaesthetic illusions were also evoked by activation of muscle receptors by vibration. 4. Illusions of movement were elicited with each type of stimulus. Electrical stimulation of skin afferents caused clear illusory movements in six out of seventeen subjects (35%), and borderline movement illusions in three out of the same seventeen subjects (total 9/17, 53%). Various other localized skin sensations were also reported. Skin stretch evoked movement illusions in eleven out of nineteen of subjects (58%). In all subjects who received both cutaneous stimuli, twelve out of seventeen (71%) reported some movement sensations with one or other of the stimulation techniques. Vibration tended to be the most reliable stimulus modality, eliciting illusory movements in fourteen out of sixteen subjects (88%). 5. Although the skin stretching technique did cause minute movements of nearby joints in several cases, these were monitored and shown in separate control experiments to be below perceptual threshold, and so the movement illusions could be safely attributed to the cutaneous afferent input evoked by skin stretch. 6. The results support the hypothesis that input from skin stretched during finger movement contributes to the conscious perception of the movement. Vibration‐evoked muscle afferent input tended to be more reliable than the skin input in producing kinaesthetic illusions, though comparisons of the relative efficacy of the three techniques must be made with caution.
A Framework for Role-Based Access Control in Group Communication Systems

In this paper we analyze the requirements access control mechanisms must fulfill in the context of group communication and define a framework for supporting fine-grained access control in client-server group communication systems. Our framework combines rolebased access control mechanisms with environment parameters (time, IP address, etc.) to provide support for a wide range of applications with very different requirements. While the access control policy is defined by the application, its efficient enforcement is provided by the group communication system.
$\ell _{p}$-MUSIC: Robust Direction-of-Arrival Estimator for Impulsive Noise Environments

A family of algorithms, named ℓp-MUSIC, for direction-of-arrival (DOA) estimation in impulsive noise is proposed. The ℓp-MUSIC estimator adopts the ℓp-norm (1 ≤ p 2) of the residual fitting error matrix as the objective function for subspace decomposition, rather than the Frobenius norm that is used in the conventional MUSIC method. Although the matrix ℓp-norm minimization based subspace decomposition will lead to a nonconvex optimization problem, two iterative algorithms are designed for achieving efficient solutions. The first algorithm is the iteratively reweighted singular value decomposition (IR-SVD), where the SVD of a reweighted data matrix is performed in each iteration. The second algorithm solves the nonconvex matrix ℓp-norm minimization by alternating convex optimization. Two complex-valued Newton's methods with optimal step size in each iteration are devised to solve the resulting convex problem. The convergence of the iterative procedure is also proved. Numerical results verify that the ℓp-MUSIC methodology outperforms the standard MUSIC scheme and several existing outlier-resistant DOA estimation approaches in terms of resolution capability and estimation accuracy.
Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00–1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I2 = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80–1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
Memory Performance at Reduced CPU Clock Speeds: An Analysis of Current x86_64 Processors

Reducing CPU frequency and voltage is a well-known approach to reduce the energy consumption of memory-bound applications. This is based on the conception that main memory performance sees little or no degradation at reduced processor clock speeds, while power consumption decreases significantly. We study this effect in detail on the latest generation of x86-64 compute nodes. Our results show that memory and last level cache bandwidths at reduced clock speeds strongly depend on the processor microarchitecture. For example, while an Intel Westmere-EP processor achieves 95% of the peak main memory bandwidth at the lowest processor frequency, the bandwidth decreases to only 60% on the latest Sandy Bridge-EP platform. Increased efficiency of memory-bound applications may also be achieved with concurrency throttling, i.e. reducing the number of active cores per socket. We therefore complete our study with a detailed analysis of memory bandwidth scaling at different concurrency levels on our test systems. Our results-both qualitative developments and absolute bandwidth numbers-are valuable for scientists in the areas of computer architecture, performance and power analysis and modeling as well as application developers seeking to optimize their codes on current x86-64 systems.
Identification of a region on the adenovirus E1a gene responsible for induction by phorbol ester tumor promoter

Summary12-O-Tetradecanoylphorbol-13-acetate (TPA) treatment induces human adenovirus (Ad) early region 1A (E1A) messenger ribonucleic acid expression in infected or Ad-transformed cells. Here, we report that deletion analysis has identified a TPA-responsive element (TRE) in the E1A enhancer region. Deletion analysis indicates that the TRE is located upstream of the E1A cap site between nucleotides −237 and −47. Incubation of extracts from TPA-treated cells with radioactively labeled deoxyribonucleic acid (DNA) fragments containing the TRE (−237 to −47) form specific DNA-protein complexes as demonstrated by gel shift analysis and Southwestern blotting. These experiments provide evidence that novel protein-DNA complexes are formed on a region of the E1A promoter required for TPA-enhanced expression. We speculate that these DNA-binding proteins may interact with the TRE and play a critical role in the mechanism through which TPA upregulates transcription from the Ad E1A gene.
An Empirical Study of Delays in the Integration of Addressed Issues

Predicting the time required to address an issue (i.e., a feature, bug fix, or enhancement) has long been the goal of many software engineering researchers. However, after an issue has been addressed, it must be integrated into an official release to become visible to users. In theory, issues should be integrated into releases soon after they are addressed. Yet in practice, the integration of an addressed issue might be delayed. For instance, an addressed issue might be delayed in order to assess the impact that it may have on the system as a whole. While one can often speculate, it is not always clear why some addressed issues are integrated immediately, while others are delayed. In this paper, we empirically study the integration of 20,995 addressed issues from the Argo UML, Eclipse, and Fire fox projects. Our results indicate that: (i) despite being addressed well before the release date, the integration of 34% to 60% of addressed issues in systems with traditional release cycle, and 98% of addressed issues in systems with rapid release cycle were delayed by one or more releases, (ii) using information derived from the addressed issues, we are able to accurately predict the release in which an addressed issue will be integrated, achieving a Receiver Operator Curve (ROC) area of above 0.74, and (iii) the workload of integrators is the most influential factor in our integration delay models. Our results indicate that integration can introduce non-negligible delays that prevent addressed issues from being delivered to users. Thus, solely focusing on the time to address an issue is not enough to truly assess how long it takes for users to see that the issue has been addressed in the software system.
The Finite temperature SU(2) Savvidy model with a nontrivial Polyakov loop

We calculate the complete one-loop effective potential for $\mathrm{SU}(2)$ gauge bosons at temperature T as a function of two variables: $\ensuremath{\varphi},$ the angle associated with a nontrivial Polyakov loop, and H, a constant background chromomagnetic field. These two variables are indicators for confinement and scale symmetry breaking, respectively. Using techniques broadly applicable to finite temperature field theories, we develop both low and high temperature expansions. At low temperatures, the real part of the effective potential ${V}_{R}$ indicates a rich phase structure, with a discontinuous alternation between confined $(\ensuremath{\varphi}=\ensuremath{\pi})$ and deconfined phases $(\ensuremath{\varphi}=0). $ The background field H moves slowly upward from its zero temperature value as T increases, in such a way that $\sqrt{\mathrm{gH}}/\ensuremath{\pi}T$ is approximately an integer. This behavior stops at ${T}_{c}=0.722(1){\ensuremath{\mu}}_{0},$ where ${\ensuremath{\mu}}_{0}$ is a zero-temperature renormalization group invariant scale; beyond this temperature, the deconfined phase is always preferred. At high temperatures, where perturbation theory should be reliable as a consequence of asymptotic freedom, the deconfined phase $(\ensuremath{\varphi}=0)$ is always preferred, and $\sqrt{\mathrm{gH}}$ is of order ${g}^{2}(T)T. $ The imaginary part of the effective potential ${V}_{I},$ which originates in a tachyonic mode associated with the lowest Landau level, is nonzero at the global minimum of ${V}_{R}$ for all temperatures. A nonperturbative magnetic screening mass of the form ${M}_{m}{=cg}^{2}(T)T$ with a sufficiently large coefficient c removes this instability at high temperature, leading to a stable high-temperature phase with $\ensuremath{\varphi}=0$ and $H=0,$ characteristic of a weakly interacting gas of gauge particles. The value of ${M}_{m}$ obtained is comparable with lattice estimates.