Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive phage therapy for Escherichia coli urinary tract infections: cocktail selection for therapy based on machine learning models

This study supports the development of predictive bacteriophage (phage) therapy: the concept of phage cocktail selection to treat a bacterial infection based on machine learning models (MLM). For this purpose, MLM were trained on thousands of measured interactions between a panel of phage and sequenced bacterial isolates. The concept was applied to Escherichia coli (E. coli) associated with urinary tract infections. This is an important common infection in humans and companion animals from which multi-drug resistant (MDR) bloodstream infections can originate. The global threat of MDR infection has reinvigorated international efforts into alternatives to antibiotics including phage therapy. E. coli exhibit extensive genome-level variation due to horizontal gene transfer via phage and plasmids. Associated with this, phage selection for E. coli is difficult as individual isolates can exhibit considerable variation in phage susceptibility due to differences in factors important to phage infection including phage receptor profiles and resistance mechanisms. The activity of 31 phage were measured on 314 isolates with growth curves in artificial urine. Random Forest models were built for each phage from bacterial genome features and the more generalist phage, acting on over 20% of the bacterial population, exhibited F1 scores of >0.6 and could be used to predict phage cocktails effective against previously untested strains. The study demonstrates the potential of predictive models which integrate bacterial genomics with phage activity datasets allowing their use on data derived from direct sequencing of clinical samples to inform rapid and effective phage therapy. Significance Statement With the growing challenge of antimicrobial resistance there is an urgency for alternative treatments for common bacterial diseases including urinary tract infections (UTIs). Escherichia coli is the main causative agent of UTIs in both humans and companion animals with multidrug resistant strains such as the globally disseminated ST131 becoming more common. Bacteriophage (phage) are natural predators of bacteria and potentially an alternative therapy. However, a major barrier for phage therapy is the specificity of phage on target bacteria and therefore difficulty efficiently selecting the appropriate phage. Here, we demonstrate a genomics driven approach using machine learning prediction models combined with phage activity clustering to select phage cocktails based only on the genome sequence of the infecting bacterial strain.
Carnegie Mellon

General: All certified teachers in Pennsylvania must earn 180 professional development hours every five years to maintain active certification status. The Pennsylvania Department of Education requires each university to name one person or office as the contact for non-credit programs offered to teachers, and we must submit a renewal application for this status every 3 years. The Gelfand Center supports teacher professional development at Carnegie Mellon by helping all departments to align programs with the requirements of the Department of Education and by reporting hours to the state’s recordkeeping system following the activities.
Ameliorative influences of Moringa oleifera leaves extract to protect the fertility from toxicity Cisplatin-induced in male rats

Moringa oleifera leaves had contained high amounts of nutritive compounds like total protein, total lipids as well as minerals content (calcium, phosphorus, potassium, iron, and sodium). Moreover, it leaves extract is a good source for natural antioxidant as total phenolic acids, flavonoids compounds, chlorophyll and carotenoids and also antioxidant activity. The biological experimental observed that the effect of Moringa oleifera leaves extract to protect the fertility from toxicity Cisplatin-induced in male rats. Moringa oleifera leaves extract was improvement oxidative stress and kidney functions. Furthermore, it was protective of the weight of the epididymis, vas deferens, and seminal vesicle as well as activity of serum testosterone (T), dehydroepiandrosterone (DHEA) levels and leptin. Moreover, the Moringa oleifera leaves extract could the improvement the fertility in rats from toxicity Cisplatin-induced when taken rats orally at 400ppm level from Moringa oleifera leaves extract. Histopathological investigation showed a betterment testicular tissue injury in Moringa oleifera therapy groups than the cisplatin group (control positive group). From the obvious studies, it could be concluded that the Moringa oleifera leaves was influential in improving the toxic impacts of cisplatin on testicular tissue in rats.
OF MULTIDISCIPLINARY: APPLIED BUSINESS AND EDUCATION RESEARCH

The pandemic COVID-19 unveiled and magnified the various learning challenges experienced by learners which yield to learning gaps, losses, and higher dropout rates, especially in the tertiary level of education. With this, there is a need to investigate on how learners are able to complete their respective course programs in the new normal. This study attempted to understand the learner’s course completion through a graduation cohort analysis approach which is anchored on a quantitative-qualitative research design. Results uncovered that gender and residency of the learners are positively correlated to the length of their course completion. In addition, the course completion varies on the learners’ gender and residency. Furthermore, 79% of the learners were able to complete their course on-time with an average of 3.72 years and standard deviation of 1.09 years. Consequently, financial, mental-health, and lack of resources were the emerging reasons for the temporary discontinuation of their studies. Hence, these findings can be used as a basis for the Philippine Private Higher Education Institution to plan and implement an institutional learning recovery program.
Peripapillary Choroidal Thickness Measurement in Primary Open-Peripapillary Choroidal Thickness Measurement in Primary Open-Angle Glaucoma Patients Using Optical Coherence Tomography Angle Glaucoma Patients Using Optical Coherence Tomography

Background : Glaucoma is one of the most typical causes of irreversible visual impairment in the globe, primary open-angle glaucoma (POAG) is the most common subtype of the disease and can impact the quality of life by affecting the visual ﬁ eld even if the patient is unaware of his diagnosis. Aim of the work : To measure the peripapillary choroidal thickness (PCT) in POAG patients and to assess the correlation between peripapillary choroidal thickness and the degree of the condition using enhanced depth imaging optical coherence tomography. Patients and methods : A prospective, observational case e control study was carried out from March 2021 till March 2022 at Al-Azhar University Hospitals involving 40 eyes of twenty-four adult subjects, 20 eyes of 10 healthy persons, and 20 eyes of 14 patients previously diagnosed with POAG. Results : Forty eyes of 24 subjects were enrolled in this study, with a mean age of 56.16 years old. 41.66% of patients were males [10/24], while females were 58.33% [14/24]. PCT in the glaucoma group was less than in the control group; however, the difference was statistically insigni ﬁ cant. Conclusion : No signi ﬁ cant correlation between PCT in POAG and the severity of the condition so peripapillary choroidal thickness has no role in the diagnosis or follow-up of primary open-angle glaucoma.
Fluid and chemical cycling at Bush Hill: Implications for gas‐ and hydrate‐rich environments

The results of a deployment of aqueous flux meters at the Bush Hill hydrate mound show that persistent hydrologic instability is a primary feature of the globally abundant gas‐ and hydrate‐rich cold seep environment. Seven flux meters were deployed for 14 weeks in the area of the Bush Hill hydrate mound. Instruments were deployed on microbial mats, bivalves, adjacent to the surface hydrate mound, and a site without visible fauna. Flow rates were observed to range from downflow of 0.01 mm/day to upflow of >15 mm/day. Temporal variability and a major hydrological event were observed to occur on all instruments. There is evidence that this event was related to a gas expulsion episode. The two instruments which exhibited downflow during the event were near surface hydrates and bubbling vents. Nearby instruments recorded a rapid increase in flow rates at the time of the event with a subsequent decrease in rates to the previous background values. Two instruments showed significant output of seawater‐like fluids, while the others output typical methane seep‐type pore fluids. These results at a passive margin site, along with our previously published convergent margin results at gas‐rich northeast Pacific cold seeps (Hydrate Ridge, Eel River margin), illustrate the hydrologic complexity of these environments. We now propose that these and our earlier results are characteristic of seafloor environments which have abundant free gas and hydrates. These mechanisms have major consequences for the near‐surface geochemical and microbial environment and for the way we interpret measurements made in these areas.
Children's Interest in a CS Career Exploring Age, Gender, Computer Interests, Programming Experience and Stereotypes

Background and Context. Increasing gender diversity in the field of Computer Science (CS) benefits the economy as well as gender equality. However, several obstacles - including underdeveloped CS interests, lack of programming experience, and a misfit with the stereotypes of computer scientists - prevent women from entering the field. Although these barriers develop from an early age, research focused on children is limited. Furthermore, limited work is done within European countries. Objectives. In this study, we research the interest children aged 7 to 14 have in a CS career. Additionally, we look into whether children with different characteristics have a different interest in CS. As such our research question: How does children’s interest in a CS career differ based on their a) age, b) gender, c) computer interests, d) programming experience, and e) stereotypical beliefs? Method. We collected data from 200 children in a science mu-seum located in the Netherlands. We gathered data on their gender, age, computer interests, programming experience, stereotypical beliefs and interest in becoming a programmer - as representative of a CS career. We used self-reported closed questions and reduced-length Child Implicit Association Tests. Findings. Ingeneral, theparticipatingchildrenarenotinterested in a CS career. We did find several characteristics related to a higher interest in a CS career: being a boy, having an interest in computers or video gaming, gaining programming experience at home or at an out-of-school activity, and the belief that programmers are social. Implications
A THEROPOD NESTING TRACE WITH EGGS FROM THE UPPER CRETACEOUS (CAMPANIAN) TWO MEDICINE FORMATION OF MONTANA

Abstract A nesting trace preserved in alluvial floodplain deposits in the Upper Cretaceous Two Medicine Formation at the Willow Creek anticline in north-central Montana contains four crushed theropod eggs referable to the oospecies Continuoolithus canadensis. These eggs immediately overlie the lower surface of a 35-cm-long × 7-cm-thick, dark-green mudstone lens, surrounded by reddish-purple mudstone. The long axes of three eggs are parallel to one another and to the lower boundary of the lens, whereas the fourth egg lies at a 30° angle to the others. A thin, 1-cm-thick organic horizon overlies the eggs, suggesting they were buried with some vegetation. Geometric modeling of the slightly asymmetrical C. canadensis eggs yields a volume and mass of approximately 194 cm3 and 205 g for each egg. This method provides a more accurate estimation for the surface area than allometric equations that are based on modern bird eggs because of the elongate shape of many non-avian theropod eggs. Pore density and water vapor conductance (GH2O) calculated from one egg in the trace and five additional C. canadensis eggs from the Willow Creek anticline vary across three regions. High, moderate, and very low GH2O characterize the equatorial zone, blunt, and tapering poles, respectively. The average GH2O for all eggs exceeds that of an avian egg of similar mass by 3.9×, thus supporting sedimentologic evidence of substrate burial during incubation.
Direct and Indirect Effects of Subjective Financial Knowledge with Direct and Indirect Effects of Subjective Financial Knowledge with Financial Satisfaction Financial Satisfaction

In this study, we differentiate subjective financial knowledge from objective financial knowledge and propose that subjective financial knowledge relates to financial satisfaction both directly as well as indirectly through financial behavior. This study used data obtained from a multi-stage random sample of household financial officers in Kerala, India (n=450). Results showed that subjective financial knowledge significantly relates to household financial officers’ financial satisfaction after controlling for objective financial knowledge and other socioeconomic factors. The relationship between subjective financial knowledge and financial satisfaction could be both direct and indirect through financial behavior. The findings suggest that financial education programs should focus on enhancing not only objective financial knowledge but also subjective financial knowledge for engaging in responsible financial behavior, which in turn relates to financial satisfaction.
Status, diversity and conservation of the mangrove forests of Sri Lanka

In Sri Lanka, mangrove forests are found scattered mainly along the north-western, north­ eastern and eastern coasts bordering lagoons and river estuaries. The area covered by the mangrove forests today is estimated as only 87 km2 (Legg & Jewell, 1995). Most of the mangrove forest areas have been subjected to human interference for a long time, and undisturbed mangrove forests are seldom found. In most areas, the mangrove forests are usually restricted to a narrow strip, sometimes only a few trees deep. The largest mangrove forest, which is in the Kala Oya estuary, is not more than 0.5 km deep and extends upstream about 2 km from the river mouth. The low level of tidal fluctuations is mainly responsible for the narrowness of the mangrove forests as only a small area comes under the tidal influence. A clear zonation is not seen in most localities because of the narrowness of the mangrove forest and the human interference. Two major kinds of mangrove forests, namely, low-saline and high-saline, could be distinguished by the floristic composition; three other specialised high saline types, scrub, overwash, and basin, are also sometimes distinguished depending on the flooding characteristics and topography. Twenty three true mangrove species of trees and shrubs have been recorded in Sri Lanka, the common species being Rhizophora mucronata, Avicennia marina, Excoecaria agallocha, Acanthus ilicifolius, Lumnitzera racemosa, Sonneratia caseolaris, Bruguiera gymnorhiza and Aegiceras corniculatum. The rare species are Ceriops decandra, Sonneratia apetala, Lumnitzera littorea, Scyphiphora hydrophyllacea and Cynometra iripa, of which the first three are endangered species in Sri Lanka. In general, the aquatic fauna, especially fish, is estuarine fauna. Cerithidea cingulata and Terebralia palustris (Gastropoda) are very common. The latter species as well as grapsid crabs, fiddler crabs and the mud-lobster (Thalassina anomala) are usually not found outside mangrove areas. Of the vertebrate fauna, avifauna is the most abundant and a variety of wading birds use mangroveassociated estuaries and lagoons for feeding and mangrove trees for roosting and nesting. Strict conservation measures are urgently required, especially in the face of the increased destruction of mangrove forests in recent years for the construction of prawn culture ponds.
Compositional characteristics and paragenetic relations of magnesiohögbomite in aluminous amphibolites from the Belomorian complex, Baltic Shield, Russia

Abstract This study investigates the compositional characteristics, parageneses, and stability relations of some högbomite-bearing assemblages in coarse-grained corundum-garnet amphibolites from a blackwall zone that separates troctolitic metagabbro from kyanite-bearing paragneiss at Diadina Mountain, Belomorian Belt, Russia. The blackwall zone presumably was formed through infiltration driven metasomatism during the Svecofennian metamorphic event at ~1.9 Ga. Euhedral högbomite grains (up to 15 mm in size) occur in domains of coarse tschermakitic amphibole, biotite, and spinel with minor rutile and ilmenite in the two blackwall varieties having contrasting bulk compositions. The other minerals in the two associations include corundum + garnet ± cordierite + chlorite + plagioclase + carbonate and spinel ± gedrite + sapphirine + chlorite + carbonate. The studied högbomite belongs to the magnesiohögbomite-2N3S polysome type [P3̅m1 with a = 5.721(1) Å, c = 23.045(1) Å] and exhibits compositions that are poor in Zn (0.05-0.42 wt% ZnO) and Ni (0.20-0.50 wt% NiO) [(Fe2+ 2.7−3.1Mn0.01Ni0.04-0.1Zn0.01-0.1)Mg4.8-3.7(Al18.1-18.8Cr0.1-0.2Fe3+0.4-0.9)Ti1.6-1.2O38(OH)2]. Compositional variation is controlled by the substitution Ti4+ + R2+ ↔ 2R3+. Systematic partitioning data for Fe2+, Mg, and Zn indicate attainment of chemical equilibrium between magnesiohögbomite and the associated minerals (Spl, Hbl, Ged, Grt, Spr, Bt) on the thin section scale. Textural relations suggest growth of magnesiohögbomite under amphibolite-facies conditions (6 ± 1 kbar, 600 ± 50 °C) through complex mineral-fluid equilibria involving oxide (Crn, Spl, Rt, Ilm), silicate (Am, Bt, Spr), and carbonate (Cal, Dol, Mgs) phases. A partial logfO₂-logfS2 diagram for the system FeO-Al2O3-TiO2-O2-S2-H2O shows that growth of magnesiohögbomite from Crn + Ilm and Spl + Rt is restricted to a narrow fO₂-window and low fS2. The topological constraints, together with petrological data, suggest that magnesiohögbomite is formed in titanian and aluminous protoliths under greenschist-to amphibolite-facies conditions if fH2O is high, fS2 low, and fO₂ is defined by the paragenesis ilmenite + rutile + magnetite
Distance to the marine protected area boundary predicts the naïve behaviour to the recreational fishing gears in a Mediterranean exploited fish species

Treball tutelat per Guillem Ramon Perez de Rada . Realitzat al Laboratori d'Ecologia de Peixos, Departament d'Ecologia i Recursos Marins (Institut Mediterrani d'Estudis Avancats (CSIC-UIB)) dintre del marc del projecte REC2 (grant#CTM2011-23835, MINECO). Treball cientificament supervisat per el Dr. Josep Alos del Department of Biology and Ecology of Fishes (Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin) amb el suport del projecte fish&fishers, UE program Marie Curie Post-Doc grants (FP7-PEOPLE-2012-IEF, grant # 327160).
Public Administration & Management

This study aimed to examine the components of academic stress that are likely to be experienced by management students in Bahir Dar University in Ethiopia. It is an in-depth investigation into each component of academic stress, i.e., identifying the micro issues that are causing stress in each of the main components of academic stress in a higher learning environment. Stressors related to curriculum and instruction, team work, assessment and placement were deeply explored. The sample comprises of 211 students that spread across the regular and continuing education programs of the department. Data were collected through self-administered questionnaire randomly distributed to respondents. It found that curriculum and instruction related stressors accounted for the highest source of stress among students followed by assessment related stressors. Consequently, the curriculum and instruction related stressor ‘studying for tests and exams’ topped the sources of academic stress among management students. The findings also revealed that students’ major stressors are academic workload, teaching methodology and aids, academic performance, lack of confidence, difficulty of courses, fear of failure, inadequate resources, lack of preparation and tough exam schedule. Even though both undergraduates and postgraduates were more likely to experience stress from all components, the findings revealed that there was a significant difference between undergraduate and postgraduate management students in the extent of their experience of the sources of academic stress in the university. The findings suggest the need for revisiting curriculum and assessment related issues as majority of students reported to experience stress due to these factors. Finally, similar interventions for these students are needed and repeating the same study in other departments and universities is recommended here with.
Challenges and Prospects for Women Entrepreneurs in Tunisia

legal characteristics of Tunisia. We are planning a qualitative study of 45 women entrepreneurs, to show the paradoxes in which these women operate and try to reconcile their desire for autonomy with respect for the traditional ways of thinking that still predominate in Tunisia. We therefore take a naturalistic view of the differences between men and women, taking account of the country's socio-economic and cultural realities, and their effects on the trajectories they have built around the differentiation of the social roles of men and women.
Wavelet Analysis of Diﬀerential TEC Measurements Obtained Using LOFAR

Radio interferometers used to make astronomical observations, such as the LOw Frequency ARray (LOFAR), experience distortions imposed upon the received signal due to the ionosphere as well as those from instrumental errors. Calibration using a well-characterised radio source can be used to mitigate these eﬀects and produce more accurate images of astronomical sources, and the calibration process provides measurements of ionospheric conditions over a wide range of length scales. The basic ionospheric measurement this provides is diﬀerential Total Electron Content (TEC, the integral of electron density along the line of sight). Diﬀerential TEC measurements made using LOFAR have a precision of < 1 mTECu and therefore enable investigation of ionospheric disturbances which may be undetectable to many other methods. We demonstrate an approach to identify ionospheric waves from these data using a wavelet transform and a simple plane wave model. The noise spectra are robustly characterised to provide uncertainty estimates for the ﬁtted parameters. An example is shown in which this method identiﬁes a wave with an amplitude an order of magnitude below those reported using GNSS TEC measurements. Artiﬁcially generated data are used to test the accuracy of the method and establish the range of wavelengths which can be detected using this method with LOFAR data. This technique will enable the use of a large and mostly unexplored dataset to study travelling ionospheric disturbances over Europe.
Antimicrobial Activities of Chloroform Extract of Whole Plant of Sida acuta Burm. f against Selected Clinical Isolates from Laboratory Samples of a Private Hospital in

: Disease-causing microorganisms pose significant health challenges, and the search for alternative therapeutics remains a present quest. Sida acuta Burm. f. is a common weed plant with reported pharmacological activities. The present study was to investigate the antimicrobial activities of chloroform extract of whole plant of S. acuta against selected clinical isolates from laboratory samples of a private hospital in Benin City