Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Diagenetic Imprint on Temperature Proxies in Holocene Corals: A Case Study From French Polynesia

Coral-based reconstructions of sea surface temperatures (SSTs) using Sr/Ca, U/Ca and δ18O are important tools for quantitative analysis of past climate variabilities. However, post-depositional alteration of coral aragonite, particularly early diagenesis, restrict the accuracy of calibrated proxies even on young corals. Considering the diagenetic effects, we present new Mid to Late Holocene SST reconstructions on well-dated (U/Th: ∼70 yr to 5.4 ka) fossil Porites sp. collected from the Society Islands, French Polynesia. For few corals, quality pre-screening routines revealed the presence of secondary aragonite needles inside primary pore space, resulting in a mean increase in Sr/Ca ratios between 5-30%, in contrast to the massive skeletal parts. Characterized by a Sr/Ca above 10 mmol/mol, we interpret this value as the threshold between diagenetically altered and unaltered coral material. At a high-resolution, observed intra-skeletal variability of 5.4 to 9.9 mmol/mol probably reflects the physiological control of corals over their trace metal uptake, and individual variations controlled by CaCO3– precipitation rates. Overall, the Sr/Ca, U/Ca and δ18O trends are well correlated, but we observed a significant offset up to ± 7°C among the proxies on derived palaeo-SST estimates. It appears that the related alteration process tends to amplify temperature extremes, resulting in increased SST-U/Ca and SST-Sr/Ca gradients, and consequently their apparent temperature sensitivities. A relative SST reconstruction is still feasible by normalizing our records to their individual mean value defined as ΔSST. This approach shows that ΔSST records derived from different proxies agree with an amplitudinal variability of up to ± 2°C with respect to their Holocene mean value. Higher ΔSST values than the mean SSTs (Holocene warm periods) were recorded from ∼1.8 to ∼2.8 ka (Interval I), ∼3.7 to 4.0 ka (Interval III) and before ∼5 ka, while lower ΔSST values (Holocene cold periods, Interval II and IV) were recorded in between. The ensuing SST periodicity of ∼1.5 ka in the Society Islands record is in line with the solar activity reconstructed from 10Be and 14C production (Vonmoos et al., 2006), emphasizing the role of solar activity on climate variability during the Late Holocene.
The Development of TPACK-Based Learning Media to Enhance the Skills of Written Communication

The research aims to develop a model of existing essay writing teaching materials. In this research, the authors used a research and development (R&D) approach to analyze and demonstrate technology as a solution to a crucial problem in teaching essay writing. Data were obtained through interviews, questionnaires, and observations. To find out the feasibility of the model to be developed, several assessment steps were carried out, namely expert/expert testing, one-on-one trials, small group trials and testing the effectiveness of teaching material models. Based on the test results, the findings of this research indicate that a new teaching material model that can stimulate lecturers and students to learn essay writing is needed. To sum up, to make an effective and enjoyable instructional process, it is necessary to be concerned with instructional methods that are varied and liked by students.
An investigation of the presence and antimicrobial susceptibility of Enterobacteriaceae in raw and cooked kibble diets for dogs in the United Kingdom

Raw meat diets (RMD) for dogs are an increasingly popular alternative pet food choice, however studies worldwide have demonstrated them to be contaminated with zoonotic and antimicrobial resistant (AMR) bacteria, including bacteria resistant to critically important antibiotics. Despite this, few data exist surrounding the presence of these bacteria in RMD in the United Kingdom. The present study aimed to identify the most commonly selected RMD and non-raw diets (NRMD) by United Kingdom dog owners. Additionally, it investigated the presence of AMR-Enterobacteriaceae in samples of pre-prepared RMD and cooked commercial kibble dog foods. An online survey investigating diet preferences of United Kingdom dog owners was open for 6 weeks between February–March 2020. From this, the top 10 brands of pre-prepared raw and cooked kibble diets were ascertained and 134 samples purchased (110 RMD, 24 kibble) and subjected to microbiological testing. Bacterial enumeration of E. coli and other Enterobacteriaceae was undertaken, and the presence of Salmonella spp. and AMR-E. coli within samples determined. Whole genome sequencing was undertaken on Salmonella spp. and third-generation cephalosporin-resistant 3GCR-E. coli isolates. Pre-prepared RMD was most commonly selected by dog owners who fed RMD, and cooked commercial complete dry food was most frequently fed by owners who fed NRMD. Damaged and leaking packaging was observed in samples of RMD, alongside variability in information provided surrounding product traceability. Counts of E. coli and other Enterobacteriaceae exceeding >5,000 CFU/g were identified in samples of RMD. AMR-, extended-spectrum beta-lactamase (ESBL)-producing and 3GCR-E. coli was isolated from 39, 14 and 16% of RMD samples, respectively. Multiple antimicrobial resistance genes were identified in 3GCR-E. coli isolates. Of the ESBL encoding genes, blaCTX-M-15 was most commonly identified. S. enterica was isolated from 5% of RMD samples. No Enterobacteriaceae were isolated from any of the cooked kibble samples. The present study suggests that pre-prepared RMD available for dogs in the United Kingdom can be contaminated with zoonotic and AMR-Enterobacteriaceae. RMDs, therefore, are potentially an important One Health concern. Veterinary and medical professionals, pet food retailers and pet owners should be aware of these risks; and stringent hygiene measures should be practiced if owners choose to feed RMD.
Sustainable growth rate, corporate value of US firms within capital and labor market distortions: The moderating effect of institutional quality

Research background: Understanding how distortions in capital and labor markets affect corporate value and sustainable growth is crucial in today's economy. These distortions can disrupt resource allocation and economic sustainability. Additionally, the role of institutional quality in shaping these dynamics requires thorough exploration. Purpose of the article: We quantify the effect of capital and labor market distortions on corporate value and sustainable growth rate (SGR) and how this association is moderated by institutional quality. Methods: Stemming from the sample criteria, we calibrated a final sample of 1971 United States-listed manufacturing firms for 2012–2022. This research offers insights into market inefficiencies and institutional effects. Progressing towards objectives, we use advanced techniques like feasible generalized least squares and generalized methods of moments. These methods help us rigorously analyze complex relationships among study variables. Findings & value added: Three key findings emerge: first, capital and labor market distortions have a negative and significant influence on corporate value and sustainable growth. Our primary finding implies that increasing distortions significantly reduce sustainable growth's value and potential. Second, we find institutional quality has a positive significant effect on corporate value and sustainable growth. Third, institutional quality positively moderates the association between capital and labor market distortions, corporate value, and sustainable growth. Findings suggest that institutional quality, as a potential mechanism, improves the efficiency of resource allocation and optimizes the sustainable economic system to lessen the negative effect of factor market distortions on corporate value and SGR. Besides, we conduct robustness checks to validate our findings. Finally, we offer policymakers and stakeholders actionable insights.
A closed life-cycle model for Northeast Arctic cod

For Northeast Arctic cod (Gadus morhua), there is much knowledge available concerning the main population dynamics processes (growth, maturation, fecundity, recruitment, natural mortality, fishing mortality). This knowledge is incorporated into a biologically detailed agelength structured population model. The model contains four population groups: EggsandLarvae, 0-group, immatures (age 1-10) and matures (age 4-12+). Recruitment to EggsandLarvae is modelled as a function of the number of mature fish and their population characteristics (length and weight), giving a fully closed life cycle. The model is implemented using the Gadget framework for population models, and the details of the implementation are described here. Results of fitting the population model to observations are presented. The utility of such a model in the assessment of current stock status and the exploration of harvest control rules is discussed.
The Effects of Suspension Training on Dynamic, Static Balance, and Stability: An Interventional Study

Background and Objectives: While suspension training devices are increasingly gaining popularity, there is limited evidence on their effects on balance, and no comprehensive assessment has been conducted. This study aimed to evaluate the effects of a 9-session suspension training program on dynamic and static balance, stability, and functional performance. Materials and Methods: A total of forty-eight healthy adults, aged between 18 and 30, participated in a 9-session suspension training program. The program included exercises targeting upper and lower body muscles as well as core muscles. Balance was comprehensively assessed using various dynamic balance tests, including the Y Balance Test (YBT) as the primary outcome, single-leg Emery test, and sideways jumping test. Static balance was evaluated through the monopedal and bipedal Romberg tests. Changes from baseline were analyzed using a one-way ANOVA test. Results: Thirty-nine participants (mean age: 21.8 years) completed the intervention. The intervention resulted in significant improvements in YBT, jumping sideways, Emery, and 30s-SST scores (p < 0.001). Platform measures indicated enhanced monopedal stability (p < 0.001) but did not show a significant effect on bipedal stability (p > 0.05). Conclusions: Suspension training is a safe and feasible method for improving dynamic balance and functional performance in healthy, untrained young adults. However, it does not appear to significantly impact the ability to maintain a static posture while standing.
Population of Coconut Crab (Birgus latro) in Fam Island, Raja Ampat, Indonesia

This research was conducted inthe villages of Korwo Iba and Meos Ambower, Fam Islands Raja Ampat Regency, Southwest Papua Province, will be implemented within 3 years, namely 2020 to 2022. The purpose of this study was to evaluate the coconut crab population and its sex population (comparison of the number of male and female sexes), the relationship between body weight and length coconut crab carapace. This research uses descriptive quantitative and qualitative with the technique of reviewing the results of previous research journals. The data analysis used was the calculation of the relationship between length and weight of fish growth by Effendi 2002. The method of collecting morphometric data from a number of coconut crab samples. Based on the research results obtained,p.s The population of coconut crabs decreased because the male coconut crab population was more dominant than the females, vegetation factors and the activity of local people who caught coconut crabs for trade or consumption. The relationship between carapace length and body weight of the coconut crab produces a value of b less than 3 (<3) which indicates a negative allometric, which means that the length gain is faster than the body weight gain .
High Prevalence of Multidrug-Resistant Bacteria in the Trachea of Intensive Care Units Admitted Patients: Evidence from a Bangladeshi Hospital

Recent research has shown that antibiotic-resistant microorganisms are becoming more prevalent in intensive care units (ICUs) at an exponential rate. Patients in the ICU can get infected by pathogens due to invasive operation procedures and critical health conditions. This study primarily emphasized tracheal samples from ICU patients due to their reliance on ventilators, increasing their susceptibility to Ventilator-Associated Pneumonia (VAP). Moreover, the rise of multidrug-resistant (MDR) pathogens makes treatment strategies more challenging for these patients. In this study, we tested 200 tracheal specimens to determine the prevalence of microorganisms and analyzed the antibiotic susceptibility of these isolates against regular antibiotics, including 4th generation drugs. Among the 273 isolates, 81% were gram-negative bacteria, 10% were gram-positive bacteria, and 9% were fungi. The most prevalent gram-negative bacteria were Acinetobacter spp. (34%), Klebsiella spp. (22%), Pseudomonas spp. (14%), and Escherichia coli (9.2%). The most prevalent gram-positive bacteria were Staphylococcus aureus (5.9%), and the fungi were Candida spp. (7.3%). Among the most prevalent bacteria, except Staphylococcus aureus isolates, around 90% were resistant to multiple drugs, whereas 60% of Acinetobacter spp. and Pseudomonas spp. were extensively drug resistant. Sensitivity analysis against the gram-negative and gram-positive drug panel using a one-way ANOVA test followed by Tukey’s post hoc test showed that in the in vitro assay, colistin was the most effective antibiotic against all gram-negative bacteria. In contrast, linezolid, vancomycin, and fusidic acid were most effective against all gram-positive bacteria. Regular monitoring of nosocomial infections and safe management of highly resistant bacteria can help prevent future pandemics.
New Polyene Macrolide Compounds from Mangrove-Derived Strain Streptomyces hiroshimensis GXIMD 06359: Isolation, Antifungal Activity, and Mechanism against Talaromyces marneffei

Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (1–4), along with seven known analogs (5–11), were isolated from the fermentation broth of the mangrove strain Streptomyces hiroshimensis GXIMD 06359. All compounds from this strain were purified using semi-preparative HPLC and Sephadex LH-20 gel filtration while following an antifungal activity-guided fractionation. Their structures were elucidated through spectroscopic techniques including UV, HR-ESI-MS, and NMR. These compounds exhibited broad-spectrum antifungal activity against Talaromyces marneffei with minimum inhibitory concentration (MIC) values being in the range of 2–128 μg/mL except compound 2. This is the first report of polyene derivatives produced by S. hiroshimensis as bioactive compounds against T. marneffei. In vitro studies showed that compound 1 exerted a significantly stronger antifungal activity against T. marneffei than other new compounds, and the antifungal mechanism of compound 1 may be related to the disrupted cell membrane, which causes mitochondrial dysfunction, resulting in leakage of intracellular biological components, and subsequently, cell death. Taken together, this study provides a basis for compound 1 preventing and controlling talaromycosis.
The role of anticipated emotions in self-control: linking self-control and the anticipatory ability to engage emotions associated with upcoming events

Self-control is typically attributed to “cold” cognitive control mechanisms that top-down influence “hot” affective impulses or emotions. In this study we tested an alternative view, assuming that self-control also rests on the ability to anticipate emotions directed toward future consequences. Using a behavioral within-subject design including an emotion regulation task measuring the ability to voluntarily engage anticipated emotions towards an upcoming event and a self-control task in which subjects were confronted with a variety of everyday conflict situations, we examined the relationship between self-control and anticipated emotions. We found that those individuals (n = 33 healthy individuals from the general population) who were better able to engage anticipated emotions to an upcoming event showed stronger levels of self-control in situations where it was necessary to resist short-term temptations or to endure short-term aversions to achieve long-term goals. This finding suggests that anticipated emotions may play a functional role in self-control-relevant deliberations with respect to possible future consequences and are not only inhibited top-down as implied by “dual system” views on self-control.
Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multi-faceted illness. Heterogenous onset and clinical presentation with additional comorbidities make it difficult to diagnose, characterize, and successfully treat. Current treatment guidelines focus on symptom management, but with no clear target or causative mechanism, remission rates are low, and fewer than 5% of patients return to their pre-morbid activity levels. Therefore, there is an urgent need to undertake robust clinical trials to identify effective treatments. This review synthesizes insights from clinical trials exploring pharmacological interventions and dietary supplements targeting immunological, metabolic, gastrointestinal, neurological, and neuroendocrine dysfunction in ME/CFS patients which require further exploration. Additionally, the trialling of alternative interventions in ME/CFS based on reported efficacy in the treatment of illnesses with overlapping symptomology is also discussed. Finally, we provide important considerations and make recommendations, focusing on outcome measures, to ensure the execution of future high-quality clinical trials to establish clinical efficacy of evidence-based interventions that are needed for adoption in clinical practice.
Digital Wallet Adoption in Supporting Financial Inclusion: A Conceptual Framework

The integration of fintech and banking has given rise to digital wallets, transforming global financial transactions and contributing to the advancement of financial inclusion. These wallets facilitate electronic payments and data access via devices, catering to the demand for secure and convenient transactions. While adoption is on the rise worldwide, Brunei's uptake has been slower due to novelty. Introduced in 2018, BruPay gained popularity among millennials and Gen Z for its user-friendly features. The pandemic accelerated digital wallet use, leading to the emergence of new players like DST Pay and Progresif Pay. This paper employs the UTAUT model to develop a framework elucidating the factors influencing local digital wallet adoption. It integrates constructs originating from literature, based on the clusters of personal belief (i.e., performance expectancy, effort expectancy, social belief), product attributes (i.e., customer support services, lifestyle compatibility, promotional benefits), and user's personality traits (i.e., personal innovativeness in information technology). The insights provide a contextual understanding of adoption trends in the country.
Virus induced gene silencing confirms oligogenic inheritance of brown stem rot resistance in soybean

Brown Stem Rot (BSR), caused by the soil borne fungal pathogen Phialophora gregata, can reduce soybean yields by as much as 38%. Previous allelism studies identified three Resistant to brown stem Rot genes (Rbs1, Rbs2, and Rbs3), all mapping to large, overlapping regions on soybean chromosome 16. However, recent fine-mapping and genome wide association studies (GWAS) suggest Rbs1, Rbs2, and Rbs3 are alleles of a single Rbs locus. To address this conflict, we characterized the Rbs locus using the Williams82 reference genome (Wm82.a4.v1). We identified 120 Receptor-Like Proteins (RLPs), with hallmarks of disease resistance receptor-like proteins (RLPs), which formed five distinct clusters. We developed virus induced gene silencing (VIGS) constructs to target each of the clusters, hypothesizing that silencing the correct RLP cluster would result in a loss of resistance phenotype. The VIGS constructs were tested against P. gregata resistant genotypes L78-4094 (Rbs1), PI 437833 (Rbs2), or PI 437970 (Rbs3), infected with P. gregata or mock infected. No loss of resistance phenotype was observed. We then developed VIGS constructs targeting two RLP clusters with a single construct. Construct B1a/B2 silenced P. gregata resistance in L78-4094, confirming at least two genes confer Rbs1-mediated resistance to P. gregata. Failure of B1a/B2 to silence resistance in PI 437833 and PI 437970 suggests additional genes confer BSR resistance in these lines. To identify differentially expressed genes (DEGs) responding to silencing, we conducted RNA-seq of leaf, stem and root samples from B1a/B2 and empty vector control plants infected with P. gregata or mock infected. B1a/B2 silencing induced DEGs associated with cell wall biogenesis, lipid oxidation, the unfolded protein response and iron homeostasis and repressed numerous DEGs involved in defense and defense signaling. These findings will improve integration of Rbs resistance into elite germplasm and provide novel insights into fungal disease resistance.
A new era in Alzheimer’s disease management: exploring aducanumab’s potential

Alzheimer’s disease (AD) is a deadly neurological condition associated with symptoms of memory loss and progressive cognitive deterioration. As an age-related disorder, it has been challenging the medical departments globally, leading to profound social and economic implications. Although its pathogenesis is not fully understood, many scientists have reached a consensus on the relationship between amyloid-beta protein peptide accumulation and cognitive decline. Aducanumab, an innovative monoclonal antibody treatment, targets the aggregated plaques and seeks to promote clearance to delay disease progression. Unlike conventional medications, aducanumab is the first therapy that allows for direct binding with amyloidogenic agents and, theoretically, leads to the activation of the immune system. In this review, the author provides an overview of Aducanumab’s mechanism and potential disadvantages, highlighting its critical role in slowing disease progression and emphasizing the controversy surrounding the accelerated approval. This paper also introduces investigational therapies that offer promising avenues offering hope for improved AD treatments and better quality of life for those affected. By revealing Aducanumab’s journey from research laboratories to the clinic, the global medical community can better understand the pathophysiology of AD, which further pave the way for a more comprehensive approach to managing this devastating neurological condition in the future.