Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile-health intervention for smoking cessation among Cambodian people living with HIV: A mixed-methods pilot study

ABSTRACT This mixed methods study aimed to evaluate the feasibility and preliminary efficacy of a fully automated, interactive smartphone-delivered intervention for smoking cessation among people living with HIV in Cambodia. We used the explanatory sequential design, with a pilot two-group single-blind randomized controlled trial (N = 50) followed by in-depth interviews with all trial participants. In the trial, participants were randomized to Standard Care (SC) or Automated Messaging (AM) group. SC comprised brief advice to quit and self-help materials. AM consisted of the SC components plus a fully automated smartphone-based treatment program that involved interactive and tailored proactive messaging for 2 months. Results showed that the AM approach was highly feasible and efficacious. Feasibility was supported by high rates of treatment engagement (e.g., 81% of delivered messages and assessments were read or completed) and high retention (96%) through the 2-month follow-up. Biochemically verified point prevalence abstinence at follow-up was 40% for the AM group and 8% for the SC group (relative risk: 5.0, 95% confidence interval: 1.2, 20.5). Being able to avoid other smokers, having coping skills, and having social/familial support contributed to successful abstinence. The AM program has the potential for wide-scale implementation in Cambodia and other low-income countries.
Filifactor alocis: Recent Insights and Advances

Filifactor alocis, a fastidious Gram-positive obligate anaerobic bacterium, is a newly appreciated member of the periodontal community that is now proposed to be a diagnostic indicator of periodontal disease. Its pathogenic characteristics are highlighted by its ability to survive in the oxidative stress–rich environment of the periodontal pocket and to significantly alter the microbial community dynamics by forming biofilms and interacting with several oral bacteria. Here, we describe the current understanding of F. alocis virulence attributes, such as its comparative resistance to oxidative stress, production of unique proteases and collagenases that can cause structural damage to host cells, and dysregulation of the immune system, which enable this bacterium to colonize, survive, and outcompete other traditional pathogens in the inflammatory environment of the periodontal pocket. Furthermore, we explore the recent advancements and future directions for F. alocis research, including the potential mechanisms for oxidative stress resistance and our evolving understanding of the interactions and mechanisms of bacterial survival inside neutrophils. We also discuss the current genetic tools and challenges involved in manipulating the F. alocis genome for the functional characterization of the putative virulence genes. Collectively, this information will expedite F. alocis research and should lead to the identification of prime targets for the development of novel therapeutics to aid in the control and prevention of periodontal disease.
Adult Liver Disease Prognostic Modelling for Long-term Outcomes in Biliary Atresia

ABSTRACT Objectives: To assess the utility of prognostic scoring systems for adolescents with biliary atresia (BA) surviving with native liver, for predicting the subsequent requirement for liver transplantation (LT). Methods: Single-centre retrospective analysis of 397 BA patients who received Kasai Portoenterostomy (KP) 1980–1996 and survived with the native liver at 16 years. Laboratory and clinical variables at 16 years (timepoint 16 years) were used to calculate (i) LT allocation scores; Model for End-Stage Liver Disease [MELD/MELD-sodium (Na)], and UK End-Stage Liver Disease (UKELD); (ii) Mayo Primary Sclerosing Cholangitis risk score (MayoPSC) and (iii) a modified Paediatric End-Stage Liver Disease (PELD) score. Scores were compared between patients requiring LT after 16 years of age (LT > 16 years), and those who survived with native liver, at the latest follow-up. Additional subgroup analysis for patients with data available at 12 years (timepoint 12 years). Results: MELD (area under the receiver operating characteristic [AUROC] 0.847) and UKELD (AUROC: 0.815) at 16 years of age predict the need for LT > 16 years. No advantage for MELD-Na over MELD was demonstrated. MELD >8.5 and UKELD >47 predicted LT > 16 years with 84% and 79% sensitivity and 73% and 73% specificity. PELD had a similar performance to MELD, but superiority to UKELD. MayoPSC revealed predictive accuracy for LT >16 years (AUROC 0.859), with a score of >0.87 predicting LT > 16 years with 85% sensitivity and 82% specificity. At timepoint 12 years, MELD and MayoPSC predicted LT >16 years. Change in MELD, PELD and MayoPSC between 12 and 16 years of age, was associated with LT >16 years. Conclusions: Adult LT allocation scores may help monitor progress in adolescent BA, but the omission of relevant risk factors limits their utility for listing in this cohort. A BA-specific prognostic score would improve the management of adolescent BA.
Effect of different drying methods on drying characteristics, colour, total phenolic content and antioxidant capacity of Goldenberry (Physalis peruviana L.)

Summary In this study, the effects of convective, microwave and microwave–convective drying methods on the drying characteristics, colour, total phenolic content and antioxidant capacity of goldenberry fruits were investigated. To select the most appropriate thin-layer drying model for drying treatments, nine mathematical drying models were fitted to the experimental data. Based on the statistical tests used for evaluation, the Midilli et al. and Wang and Singh models were considered the best models to describe the drying behaviours of goldenberry fruits in all drying methods. The colour values (L*, a* and b*) of fresh fruit were decreased by drying. Compared with the fresh sample, the dried samples exhibited a 64–75% and 65–75% decrease in total phenolic content and antioxidant capacity, respectively. Among the different drying treatments, the values closest to those of fresh samples with respect to colour values, total phenolic content and antioxidant capacity were achieved with the 160 W microwave drying method.
Cleft Care in a Developing Country: An Assessment of Knowledge and Attitudes of Patients/Parents of Children With an Orofacial Cleft to Orthodontic Treatment

Objective: To assess the knowledge, awareness and attitude to orthodontic treatment of patients and parents of children with orofacial clefts, receiving comprehensive cleft care treatment. Design: Cross-sectional survey. Setting: A major tertiary health care facility in Nigeria, the Lagos University Teaching Hospital, Idi-araba, Lagos. Participants: Patients and parents of children with orofacial clefts receiving comprehnsive cleft care. Intervention: Patients and parents of children with orofacial clefts were asked to complete the survey. Interviewer-administered questionnaires were used. Results: A total of 123 patients participated in the study, 55.3% (68) were females and 44.7% (55) were males. The majority (85.3%, 114) of patients were children aged between 0 and 5 years, while only 7.3% (9) were adults, aged 18 years and above. About one-third (41) of the respondents indicated that they felt “their teeth was not straight. ” Although 43.9% (54) reported that they knew that braces could be used to straighten teeth, only 13.8% of the respondents knew who an orthodontist was. Eighty percent (99) indicated that they would be willing to undergo treatment to straighten their teeth or their children/wards’ teeth. Conclusion: The majority of parents of children with clefts and adult patients attending the institution’s cleft clinic had limited knowledge of orthodontics and the orthodontic care required for patients with clefts, although they had a positive attitude toward orthodontic treatment. These findings will guide the center in planning patient-centered orthodontic care for patients with clefts while also highlighting areas of importance for patient counseling and education in the orthodontic care for these patients.
Prenatal exposure to butyl paraben is associated with fat percentage in 7-year old boys.

CONTEXT Parabens are used as preservatives in consumer products but are suspected of having endocrine-disrupting properties. A recent study reported an association between in utero exposure to butyl paraben and overweight in childhood, with a stronger trend in girls. OBJECTIVE We therefore studied the association between parabens in maternal urine in third trimester and fat percentage in children aged 7 years. DESIGN, SETTING & PARTICIPANTS We used data from the Odense Child Cohort, a mother-child cohort with enrollment from 2010-2012, in which the children are followed. Paraben concentration was assessed in maternal urine at median gestational week 28.7 and body composition measured as total, gynoid, and android fat percentages assessed by Dual Xray Absorptiometry in their children at age 7 years. MAIN OUTCOME MEASUREMENTS Total, Gynoid, and Android fat percentages and z-score for BMI. INTERVENTIONS None. RESULTS Paraben exposure was low. In multivariate linear regressions, detection of butylparaben in maternal urine was associated with an increase of 17% (95% confidence intervals CI 3.0%;32%) in total body fat percentage and an increase of 23% (95% CI 5.1%;43%) in android fat percentage in boys, compared to boys whose mother had no detectable butylparaben in urine. No significant associations between in utero exposure to methyl-, ethyl- or propyl parabens and body composition were found, and no significant associations were seen in girls. CONCLUSION Our findings suggest that parabens, which are believed to have low toxicity, may affect obesity development at vulnerable time periods during development.
Family Interaction and Depressive Symptoms in Chinese Emerging Adults: A Mediation Model of Gratitude

In this study, we investigated the relations between family interaction, gratitude, and depressive symptoms among Chinese emerging adults. It also investigated gratitude as a mediator in the relation between family interaction and depression. Data were obtained from 321 college students who completed the online questionnaire about the Family Assessment Instrument, Gratitude Questionnaire, Patient Health Questionnaire, and demographic information. Structural equation modeling (SEM) was used to test hypotheses and bootstrapping with 5,000 resamplings (95% confidence interval) was used to confirm the mediation model. Results showed that gratitude partially mediated the relation between family interaction and depression. In other words, students with healthy family interaction, as indicated by perceived better family communication, mutuality, and harmony with family members, tended to report higher general gratitude, and subsequently diminished depressive symptoms. The practical implications were discussed.
Sex‐linked genetic diversity and differentiation in a globally distributed avian species complex

Sex chromosomes often bear distinct patterns of genetic variation due to unique patterns of inheritance and demography. The processes of mutation, recombination, genetic drift and selection also influence rates of evolution on sex chromosomes differently than autosomes. Measuring such differences provides information about how these processes shape genomic variation and their roles in the origin of species. To test hypotheses and predictions about patterns of autosomal and sex‐linked genomic diversity and differentiation, we measured population genetic statistics within and between populations and subspecies of the barn swallow (Hirundo rustica) and performed explicit comparisons between autosomal and Z‐linked genomic regions. We first tested for evidence of low Z‐linked genetic diversity and high Z‐linked population differentiation relative to autosomes, then for evidence that the Z chromosome bears greater ancestry information due to faster lineage sorting. Finally, we investigated geographical clines across hybrid zones for evidence that the Z chromosome is resistant to introgression due to selection against hybrids. We found evidence that the barn swallow mating system, demographic history and linked selection each contribute to low Z‐linked diversity and high Z‐linked differentiation. While incomplete lineage sorting is rampant across the genome, our results indicate faster sorting of ancestral polymorphism on the Z. Finally, hybrid zone analyses indicate barriers to introgression on the Z chromosome, suggesting that sex‐linked traits are important in reproductive isolation, especially in migratory divide regions. Our study highlights how selection, gene flow and demography shape sex‐linked genetic diversity and underlines the relevance of the Z chromosome in speciation.
Commercial Sexual Exploitation of Children and Adolescents in Europe: A Systematic Review

Objectives: The objective of this review is to provide a systematic and critical summary of findings regarding empirical studies conducted on commercial sexual exploitation of children (CSEC) in Europe. The purpose is to gain an understanding of the characteristics and main topics addressed in European research on CSEC, identify gaps, and give suggestions for future studies. Method: The review was guided by the “Preferred Reporting Items for Systematic Review and Meta-Analysis—Protocols”. A comprehensive search on several databases was conducted to identify published and unpublished empirical research on CSEC in Europe, revealing 3,846 documents. In total, 56 research papers that focused specifically on CSEC in European samples were included. Synthesis: Research concerning European studies of CSEC and trafficking for purposes of sexual exploitation has developed significantly over the last 20 years but is still rather limited and mainly focused on the UK and Sweden. Most of the studies reviewed suffer from important methodological flaws such as an inaccurate definition of the phenomenon analyzed, small and convenience samples, and nonvalidated and nonspecific instruments. Conclusions: Findings from this study demonstrate the need for greater exploration and research around a number of areas of sexual exploitation of children in Europe. Further work is necessary in terms of capacity building, training, and awareness-raising for society as a whole and, specifically, professionals providing direct support to children and young people at risk of exploitation.
Association between Asthma and Internet Addiction Status in Korean Adolescents

Background Problematic Internet addiction (IA) has been shown to be associated with a variety of psychological comorbidities, but its relationship with adolescent asthma has not yet been investigated in detail. Methods We analyzed 18,473 adolescent patients with physician-diagnosed asthma and 205,069 non-asthmatic adolescent patients from the Korean Youth Risk Behavior Web-based Survey. Socioeconomic factors, health behavior factors, psychological factors, and IA status were assessed using the Korean Internet Addiction Proneness Scale. Multiple logistic regression analysis was performed, with adjustment for multiple cofounders, to explore the association between IA and adolescent asthma. Results Comparison between the adolescent asthma group and non-adolescent asthma group indicated higher rates of probable IA (13.7% vs. 12.1%, respectively, P<0.001), IA (4.8% vs. 3.1%, respectively, P<0.001), and problematic IA (18.5% vs. 15.2%, respectively, P<0.001) in the adolescent asthma group. After adjustment for multiple confounders, probable IA [odds ratio (OR): 1.16, 95% confidence interval (CI): 1.08–1.26] and IA (OR: 1.07, 95% CI: 1.02–1.12) were significantly associated with increased risk of adolescent asthma, compared to non-problematic Internet use. Conclusions IA is associated with an increased rate of asthma in Korean adolescents. So, IA has attracted minimal attention in relation to the treatment of asthma.
X-Entropy: A Parallelized Kernel Density Estimator with Automated Bandwidth Selection to Calculate Entropy

X-Entropy is a Python package used to calculate the entropy of a given distribution, in this case, based on the distribution of dihedral angles. The dihedral entropy facilitates an alignment-independent measure of local protein flexibility. The key feature of our approach is a Gaussian kernel density estimation (KDE) using a plug-in bandwidth selection, which is fully implemented in a C++ backend and parallelized with OpenMP. We further provide a Python frontend, with predefined wrapper functions for classical coordinate-based dihedral entropy calculations, using a 1D approximation. This makes the package very straightforward to include in any Python-based analysis workflow. Furthermore, the frontend allows full access to the C++ backend, so that the KDE can be used on any binnable one-dimensional input data. In this application note, we discuss implementation and usage details and illustrate potential applications. In particular, we benchmark the performance of our module in calculating the entropy of samples drawn from a Gaussian distribution and the analytical solution thereof. Further, we analyze the computational performance of this module compared to well-established python libraries that perform KDE analyses. X-Entropy is available free of charge on GitHub (https://github.com/liedllab/X-Entropy).
Electrochemical study of Alamar Blue (resazurin) in aqueous solutions and room-temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate at a glassy carbon electrode

Electrochemical behaviour of Alamar Blue (resazurin) at a glassy carbon electrode in aqueous buffered solutions and room-temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, [C4mim][BF4], was studied using the cyclic voltammetry, chronoamperometry and chronocoulometry techniques. Our data confirm that the electrochemical reduction of resazurin in aqueous solutions takes place in two processes. In the first step, the cyclic voltammogram reveals an irreversible two-electron process leading to resorufin, whereas in the second step, cyclic voltammogram displays a reversible two-electron process related to the formation of dihydroresorufin. In [C4mim][BF4], however, our voltammetric data indicate that the reduction of resazurin takes place in two one-electron processes. The diffusion coefficient of resazurin in aqueous buffered solution and in [C4mim][BF4] was also determined using the both single potential-step chronoamperometry and chronocoulometry techniques. It is found that the diffusion coefficient varies from 8.5 × 10−7 cm2 s−1 in aqueous solution to 1.2 × 10−7 cm2 s−1 in [C4mim][BF4]. The orientation of adsorbed resazurin on the surface of glassy carbon electrode was also estimated. It is found that the orientation of the adsorbed resazurin at glassy carbon surface is edgewise.
Reliability of a smartphone application to measure physical activity

ABSTRACT The aim of this study was to evaluate how accurate is a smartphone app to measure a physical activity parameter (steps). Physical Education undergraduate students (n = 46), both male and female, were recruited. A tally counter, a validated device (Xiaomi Mi Band 2®) and My Active Life app were used to perform the steps count. Each participant took three low-intensity treadmill walks (5 km h−1), with a number of target steps (500-, 1000- and 1500-steps walk). Visual agreement analyses was performed through Bland-Altman plots. There was no significant interaction between steps walks and device during treadmill walking test (F (2,84) = 3.854; p = 0.07). Differences in steps measured by Mi Band were not different from 0 in 500-steps walk (p = 0.243) and 1000-steps walk (p = 0.350), and in My Active Life in 500-steps walk (p = 0.177) and 1500-steps walk (p = 0.221). Bland-Altman analyses indicated an acceptable agreement between My active Life app and Mi Band devices for 1000-steps walk (−359.01; 310.43) and 1500-steps walk (−572.97; 377.11). In conclusion, My Active Life app showed accuracy in measuring total steps, in longer walking activities (e.g. higher than 1000 steps), and can be used on a daily basis and in research setting.
Efficacy and safety of holmium laser enucleation of the prostate for elderly patients: surgical outcomes and King’s Health Questionnaire

Background Holmium laser enucleation of the prostate (HoLEP) has been a widely utilized minimally invasive surgical procedure for benign prostate hyperplasia. The current study aimed to compare surgical outcomes and King’s Health Questionnaire (KHQ) assessment scores following HoLEP between younger men and those aged ≥75 years. Methods This prospective single-center study compared perioperative complications, postoperative urinary conditions, and KHQ scores (nine categories) between men aged ≥75 years (group A) and men aged <75 years (group B) before and 1, 3, and 6 months after surgery. Results A total of 100 patients were included for analysis (group A, n=38 and group B, n=62). No differences in patient backgrounds, perioperative complications, such as perioperative decrease in hemoglobin, postoperative fever, postoperative indwelling catheterization duration, or postoperative hospitalization duration, and KHQ were observed between both groups. Both groups showed significantly better International Prostate Symptom Scores, quality of life, maximum urinary ﬂow rate, and postvoid residual volume 1, 3, and 6 months after HoLEP compared to their respective preoperative levels (P<0.01). Regarding KHQ categories, both groups showed significantly better general health perceptions, impact on life, emotions, and sleep/energy 1 month after HoLEP; role limitations, physical limitations, and social limitations 3 months after HoLEP; and personal relationships and incontinence severity measures 6 months after HoLEP compared to their respective preoperative levels (P<0.05). Conclusions HoLEP could be safe and effective even for men aged ≥75 years, comparing complications, urinary condition, and KHQ scores.
Attachment dimensions and cortisol responses during the strange situation among young children adopted internationally

ABSTRACT Children’s attachments to their parents may help regulate their hypothalamic-pituitary-adrenal (HPA) axes. Prior research has largely focused on children with relatively consistent and low-risk caregiving histories, resulting in limited knowledge about the associations between attachment quality and HPA axis reactivity among children who have experienced early adversity. This study investigated whether dimensional measures of attachment quality were associated with HPA responses to the Strange Situation Procedure (SSP) among 64 children ages 11–33 months adopted internationally from institutional or foster care. Children who showed high levels of attachment avoidance exhibited a blunted cortisol response during the SSP. Conversely, children who sought proximity and contact with their adoptive parents exhibited an increase in cortisol reactivity during the SSP, followed by a return to baseline levels after the completion of the procedure. This association was independent of the previously reported association between parental insensitivity and blunted cortisol responses in this sample.