Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Motor Symptoms, Signs, and Parkinsonism with Facial Emotion Recognition Deficits in Individuals with 22q11.2 Deletion Syndrome at High Genetic Risk for Psychosis

Background. The 22q11.2 Deletion Syndrome (22q11.2DS) is a genetic condition at high risk of developing both psychosis and motor disorders. Social Cognition (SC) deficits have been associated not only with schizophrenia but also with Parkinson’s disease (PD). The present study assessed SC deficits in 22q11.2DS and investigated the interaction between motor symptoms and deficits in Facial Emotion Expressions (FEE) recognition and in Theory of Mind (ToM) tasks in people with 22q11.2DS. Methods. We recruited 38 individuals with 22q11.2DS without psychosis ( N = 38 , DEL) and 18 with 22q11.2DS and psychosis ( N = 18 , DEL_SCZ). The Positive And Negative Syndrome Scale (PANSS), Ekman’s 60 Faces Test (EK-60F), the Awareness of Social Inference Test (TASIT EmRec), and the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III (UPDRS III) were administered. Correlations were sought between UPDRS III and both TASIT EmRec and EK-60F scores. Analyses were conducted separately for each psychopathological subgroup. Results. Higher UPDRS III ( p = 0.04 ) and lower EK-60F ( p = 0.025 ) scores were observed in the DEL_SCZ group. We found inverse correlations between UPDRS III and both TASIT EmRec ( r = − 0.289 , p = 0.031 ) and EK-60F ( r = − 0.387 , p = 0.006 ) scores in the whole sample. Correlations were no longer significant in the DEL_SCZ group (UPDRS III-TASIT EmRec p = 0.629 ; UPDRS III-EK60F p = 0.933 ) whilst being stronger in the DEL group (TASIT EmRec, r = − 0.560 , p < 0.001 ; EK60F, r = − 0.542 , p < 0.001 ). Analyses were adjusted for CPZ Eq and IQ. Conclusions. A modulation between FEE recognition deficits and motor symptoms and signs was observed in the 22q11.2DS group, likely affecting patients’ quality of life.
Response to Article “Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells” [Letter]

The work performed by Zhou et al regarding the regulative mechanism of autophagy that inhibits inflammation via down-regulation of p38 MAPK/mTOR signaling cascade in endothelial cells has been reviewed and much appreciated. 1 In their study, rapamycin-induced autophagy was shown and proven to be able to improve the function of endothelial cells in psoriasis, the chronic immune-mediated skin disease. Their results suggested that approaches to induce autophagy could be used to ameliorate psoriasis. This work supplied novelty and promising ideas in the autophagy and psoriasis fields. However, a few suggestions and recommendations for improving the further study in the fields are provided. Autophagy is a key process by which cells degrade their components to maintain homeostasis. There are some previous studies reporting the role of autophagy and its regulation in skin diseases, including skin pigmentation and skin inflammation. Previously reported data suggested that modulation of autophagy or activation of aryl hydrocarbon receptors (AHRs) could affect processes involved in epidermal differentiation and contribute to the pathogenesis of chronic inflammatory skin diseases with skin barrier abnormalities such as psoriasis. This previous study had unraveled the role of autophagy contribution in improving psoriasis by treating the polycytokine-stimulated human keratinocytes and psoriasis skin biopsies tested in their in vitro and in vivo studies. 2 In their study, Zhou et al reported
Correlation between CT Score and KL-6: A Severity Assessing in Juvenile Dermatomyositis Associated Interstitial Lung Disease

Background There is no radiological measurement to estimate the severity of pediatrics juvenile dermatomyositis (JDM) with interstitial lung disease (ILD). We validated the effectiveness of CT scoring assessment in JDM patients with ILD. Aim To establish a CT scoring system and calculate CT scores in JDM patients with ILD and to determine its reliability and the correlation with Krebs von den Lungen-6 (KL-6). Methods The study totally enrolled 46 JDM-ILD patients and 16 JDM without ILD (non-ILD, NILD) patients. The chest CT images (7.0 ± 3.6 years; 32 male and 30 female) were all analyzed. CT scores of six lung zones were retrospectively calculated, included image pattern score and distribution range score. Image pattern score was defined as follows: increased broncho-vascular bundle (1 point); ground glass opacity (GGO) (2 points); consolidation (3 points); GGO with bronchiectasis (4 points); consolidation with bronchiectasis (5 points); and honeycomb lung (6 points). Distribution range score was defined as no infiltrate (0 point); <30% (1 point); 30%–60% (2 points); and ≥60% (3 points). Two pediatric radiologists reviewed all CT images independently. The ROC curve was established, and the optimal cutoff score for severity discrimination was set. Results The agreement between two observers was excellent, and the ICC was 0.930 (95% CI 0.882–0.959, p < 0.01). CT score and KL-6 level had a positive linear correlation (r = 0.784, p < 0.01). However, the correlation between CT scores of different lung zone and KL-6 level was different. The KL-6 cut off level suggested for JDM with ILD was 209.0 U/ml, with 73.9% sensitivity and 87.5% specificity, and the area under curve was (AUC) 0.864 (p < 0.01). Conclusion The CT scoring system we established, as a semiquantitative method, can effectively evaluate ILD in JDM-PM patients and provide reliable evidence for treatment.
Predictors of Activities of Daily Living in Intensive Care Unit Survivors: A Propensity Score Matching Analysis

ABSTRACT Objectives: Increased long-term impairment is common among intensive care unit (ICU) survivors. However, predictors of activities of daily living (ADL) in ICU survivors are poorly understood. We aimed to focus on the trajectory of physical function and explore the clinical variables that affect ADL at hospital discharge. Methods: We enrolled 411 patients admitted to the ICU from April 2018 to October 2020. Physical function was evaluated at ICU admission, ICU discharge, and hospital discharge. We assessed physical function (grip strength, arm and calf circumference, quadriceps thickness, and Barthel index). Patients were assigned to the high or low ADL group based on their Barthel index at discharge. Propensity score matching analysis was performed to minimize selection biases and differences in clinical characteristics. Results: After matching propensity scores, 114 of the 411 patients (aged 65±15 years) were evaluated. The high ADL group showed better physical function at ICU discharge and hospital discharge than the low ADL group. An overall decreasing trend in muscle mass was observed over time; the rates of decline were lower in the high ADL group than in the low ADL group. The cutoff values for relative changes in calf circumference and quadriceps thickness to predict high ADL were −7.89% (sensitivity: 77.8%, specificity: 55.6%) and −28.1% (sensitivity: 81.0%, specificity: 58.8%), respectively. Conclusions: The relative decreases in calf circumference and quadriceps thickness during hospitalization were lower in patients who maintained their ADL. Assessment of the trajectory of physical function can predict ADL status at hospital discharge among ICU survivors.
Dental Follicle Stem Cells Promote Periodontal Regeneration through Periostin-Mediated Macrophage Infiltration and Reprogramming in an Inflammatory Microenvironment

Dental follicle stem cells (DFSCs) have been verified to promote periodontal regeneration in an inflammatory microenvironment. When coping with inflammatory stimulation, DFSCs highly express periostin, a bioactive molecule closely related to periodontal homeostasis. It is worth exploring whether and how periostin plays a role in the promotion of periodontal regeneration by DFSCs. By tracking the fate of DFSCs, it was found that DFSCs significantly contributed to periodontal regeneration in rat periodontal defects while they had a low survival rate. They highly expressed periostin and improved the immune microenvironment in the defect area, especially via the recruitment and reprogramming of macrophages. Silencing periostin attenuated the effects of DFSCs in promoting periodontal regeneration and regulating macrophages. Recombinant human periostin (rhPeriostin) could not only directly promote macrophage reprogramming through the integrin αM/phosphorylated extracellular signal-regulated kinase (p-Erk)/Erk signaling pathway, but it also exhibited the potential to promote periodontal regeneration in rats when loaded in a collagen matrix. These results indicated that periostin is actively involved in the process by which DFSCs promote periodontal regeneration through the regulation of macrophages and is a promising molecular agent to promote periodontal regeneration. This study provides new insight into the mechanism by which DFSCs promote periodontal regeneration and suggests a new approach for periodontal regeneration therapy.
Correlation between parents and child’s version of the child health survey for asthma questionnaire

ABSTRACT Background The American Academy of Pediatrics Children’s Health Survey for Asthma (CHSA) is a widely used instrument to assess various aspects of health and well-being in relation to asthma. There is a parent and a child version of this questionnaire and little is known about the concordance between these versions. Method In a cross-sectional study conducted in 13 facilities, hospitals and outpatient clinics covering all areas of Kosovo, children with asthma aged 7–16 years were enrolled. Information about asthma diagnosis was obtained from the treating physician. Children and parents answered the CHSA, parent or child version (CHSA-C) as well as a number of questions about environmental conditions, health insurance and socio-demographic characteristics Results The survey included 161 Kosovar children with asthma and their caregivers. Although there were significant differences between parents and child versions regarding physical health, child activity and emotional health, with parents rating physical and emotional health higher and child activity lower, there were significant correlations (R > 0.7) for physical and child activity scales but only a low one (R = 0.25) for emotional health. Inspection of concordance for single items revealed very high correlations (>0.9) for all disease events, but a significant underestimation of the number of wheezing episodes by parents. Good agreement was found for statements about disease severity. Conclusions The high correlation between information about children’s health obtained from parents and children underlines the usefulness of parents as source of information on child’s asthma. Impact of the disease on emotional health is, however, underestimated by parents.
Proto-Planetary Nebulae

The progress in the search for proto-planetary nebulae (PPN) in the last 5 years is reviewed. An observational definition of PPN is developed and a list of current PPN candidates is given. The optical, infrared, and radio properties of PPN are summarized and compared with theoretical models.
Transient dynamics at the onset of Taylor vortices

The effect of boundary conditions on the ‘critical dynamics’ at the onset of Taylor vortices is investigated in a combined numerical and experimental study. Numerical calculations of Navier–Stokes equations with ‘stress-free’ boundary conditions show that the Landau amplitude equation provides a good model of the transient dynamics. However, this rapidly breaks down when the ‘no-slip’ condition is approached. Apparent ‘critical’ behaviour observed in experiments is shown to have a surprising dependence on the length of the system.
Genetic Evidence for Endolysosomal Dysfunction in Parkinson’s Disease: A Critical Overview

Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the aging population, and no disease-modifying therapy has been approved to date. The pathogenesis of PD has been related to many dysfunctional cellular mechanisms, however, most of its monogenic forms are caused by pathogenic variants in genes involved in endolysosomal function (LRRK2, VPS35, VPS13C, and ATP13A2) and synaptic vesicle trafficking (SNCA, RAB39B, SYNJ1, and DNAJC6). Moreover, an extensive search for PD risk variants revealed strong risk variants in several lysosomal genes (e.g., GBA1, SMPD1, TMEM175, and SCARB2) highlighting the key role of lysosomal dysfunction in PD pathogenesis. Furthermore, large genetic studies revealed that PD status is associated with the overall “lysosomal genetic burden”, namely the cumulative effect of strong and weak risk variants affecting lysosomal genes. In this context, understanding the complex mechanisms of impaired vesicular trafficking and dysfunctional endolysosomes in dopaminergic neurons of PD patients is a fundamental step to identifying precise therapeutic targets and developing effective drugs to modify the neurodegenerative process in PD.
An asymptotic bound for the tail of the distribution of the maximum of a gaussian process

Let X(t ), t E T, be a real Gaussian process with mean 0, continuous covariance function, and continuous sample paths, where T is a closed cube in 1. The main result is a new bound for the probability P (maxT X(t ) > u), for u > 0. It is obtained by an extension of the original Fernique inequality. This bound is asymptotically smaller, for u oo, than the bound that can be obtained directly from the original inequality.
Bonding Mechanical Properties between SMA Fiber and ECC Matrix under Direct Pullout Loads

SMAF-ECC material composed of shape memory alloy fiber (SMAF) and engineered cementitious composite (ECC) has good bending and tensile properties, as well as good crack self-healing ability, energy consumption, and self-centering ability. The bond behavior between fiber and matrix is crucial to the effective utilization of the superelasticity of SMAF. The experimental study considered three variables: SMA fiber diameter, fiber end shape, and bond length. The pullout stress–strain curve of SMAF was obtained, and the maximum pullout stress, maximum bond stress, and fiber utilization rate were analyzed. Compared with the straight end and the hook end, the maximum pullout stress of the specimen using the knotted end SMAF is above 900 MPa, the fiber undergoes martensitic transformation, and the fiber utilization rate is above 80%, indicating that the setting of the knotted end can give full play to the superelasticity of the SMAF. Within the effective bond length range, increasing the bond length can increase the maximum anchorage force of the knotted end SMAF. Increasing the fiber diameter can increase the maximum pullout stress and maximum anchoring force of the knotted end SMAF but reduce the utilization rate of SMA fiber. This study provides a reliable theoretical basis for the bonding properties between SMAF and ECC.
Simulation and understanding of atomic and molecular quantum crystals

Quantum crystals abound in the whole range of solid-state species. Below a certain threshold temperature the physical behavior of rare gases (4He and Ne), molecular solids (H2 and CH4), and some ionic (LiH), covalent (graphite), and metallic (Li) crystals can be explained only in terms of quantum nuclear effects (QNE). A detailed comprehension of the nature of quantum solids is critical for achieving progress in a number of fundamental and applied scientific fields such as planetary sciences, hydrogen storage, nuclear energy, quantum computing, and nanoelectronics. This review describes the current physical understanding of quantum crystals formed by atoms and small molecules, as well as the wide palette of simulation techniques that are used to investigate them. Relevant aspects in these materials such as phase transformations, structural properties, elasticity, crystalline defects, and the effects of reduced dimensionality are discussed thoroughly. An introduction to quantum Monte Carlo techniques, which in the present context are the simulation methods of choice, and other quantum simulation approaches (e.g., path-integral molecular dynamics and quantum thermal baths) is provided. The overarching objective of this article is twofold: first, to clarify in which crystals and physical situations the disregard of QNE may incur in important bias and erroneous interpretations. And second, to promote the study and appreciation of QNE, a topic that traditionally has been treated in the context of condensed matter physics, within the broad and interdisciplinary areas of materials science.
Magnetic induction spectroscopy: non-contact measurement of the electrical conductivity spectra of biological samples

Measurement of the electrical conductivity of biological tissues as a function of frequency, often termed ‘bioelectrical impedance spectroscopy (BIS)’, provides valuable information on tissue structure and composition. In implementing BIS though, there can be significant practical difficulties arising from the electrode–sample interface which have likely limited its deployment in industrial applications. In magnetic induction spectroscopy (MIS) these difficulties are eliminated through the use of fully non-contacting inductive coupling between the sensors and sample. However, inductive coupling introduces its own set of technical difficulties, primarily related to the small magnitudes of the induced currents and their proportionality with frequency. This paper describes the design of a practical MIS system incorporating new, highly-phase-stable electronics and compares its performance with that of electrode-based BIS in measurements on biological samples including yeast suspensions in saline (concentration 50–400 g l−1) and solid samples of potato, cucumber, tomato, banana and porcine liver. The shapes of the MIS spectra were in good agreement with those for electrode-based BIS, with a residual maximum discrepancy of 28%. The measurement precision of the MIS was 0.05 S m−1 at 200 kHz, improving to 0.01 S m−1 at a frequency of 20 MHz, for a sample volume of 80 ml. The data-acquisition time for each MIS measurement was 52 s. Given the value of spectroscopic conductivity information and the many advantages of obtaining these data in a non-contacting manner, even through electrically-insulating packaging materials if necessary, it is concluded that MIS is a technique with considerable potential for monitoring bio-industrial processes and product quality.
Comparative Analysis of Regression Methods Used for Seismic Magnitude Conversions

Abstract The magnitude conversion problem, usually concerning the estimation of proxies of moment magnitude M w from local ( M L ) and teleseismic ( M s and m b ) magnitude estimates, was addressed by a number of recent articles. In most of them, the general orthogonal regression (GOR) method is employed; in place of the ordinary least squares (OLS), owing to the fact that the errors of local and teleseismic magnitudes are not negligible with respect to those of M w . In the last two years, researchers proposed a modified GOR (MGOR) procedure that claimed to achieve unbiased estimates of M w using an estimator of the true value of the independent variable ( x t ) in place of the observed value ( X obs ) in regressed equations. In this article, we demonstrate both theoretically and experimentally that (a) x t coincides on average with X obs , (b) the proposed procedure to calculate x t is biased by the choice of using the OLS regression method to fit the linear relationship between x t and X obs , and (c) the claimed better fit of MGOR proxies with observed data is due to the use of goodness‐of‐fit estimators that neglect the error of the independent variable. In particular, we show the regression method that best minimizes such estimators is the OLS, which assumes that the error of the independent variable is negligible. This, however, does not mean that the OLS is the better approach for computing conversion equations between different magnitudes; because, owing to the presence of errors of the independent variable, it is simply not applicable to magnitude conversion as well as the MGOR procedure.
Dynamic output feedback control of constrained descriptor systems

This paper aims to present an approach for design of dynamic output feedback compensators for linear discrete-time descriptor systems subject to state and control constraints. To this end, output-feedback controlled-invariant polyhedra are constructed by taking a pair of polyhedral sets: a controlled-invariant set and a conditioned-invariant set. By defining an augmented system composed of the original system plus the dynamic compensator, a control action can be computed online, which optimizes the contraction rate of the augmented state trajectory and enforces the constraints. The results are illustrated through numerical examples, which show that the proposed dynamic compensators outperform static feedback controllers under the same conditions.
Clinical effects of Bifidobacterium as a probiotic on oral health: A systematic review

Background: The burden of oral diseases is increasing, which constitute a major public health problem. The use of probiotics as an adjuvant, along with routine dental care practice by an individual, can produce additional benefits in the maintenance of one's oral health. The study aimed to investigate the effect of Bifidobacterium as a probiotic on oral health. Material and Methods: Six databases and registers were searched from the start of the database to December 2021 without any restrictions. Randomized controlled trials (RCTs) evaluating the clinical effects of Bifidobacterium as a probiotic on oral health were included in the study. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed to conduct this systematic review. The included studies were analyzed for the risk of bias using the Cochrane risk-of-bias tool for randomized trial (RoB 2) tool as well as quality of available evidence using GRADE criteria. Results: From the 22 qualified studies, four studies showed non-significant results. There was a high risk of bias in 13 studies and some concerns of bias in nine studies. No adverse effects were reported, and the quality of available evidence was moderate. Conclusion: The effect of Bifidobacterium on oral health is questionable. Further high-quality RCTs are required on the clinical effects of bifidobacteria and also the optimum level of probiotic needed, and ideal mode of administration to provide oral health benefits. Furthermore, synergistic effects of the combined use of various strains of probiotics need to be studied.
The Mean Square Error of Prediction in the Chain Ladder Reserving Method (Mack and Murphy Revisited)

We revisit the famous Mack formula [2], which gives an estimate for the mean square error of prediction MSEP of the chain ladder claims reserving method: We define a time series model for the chain ladder method. In this time series framework we give an approach for the estimation of the conditional MSEP. It turns out that our approach leads to results that differ from the Mack formula. But we also see that our derivation leads to the same formulas for the MSEP estimate as the ones given in Murphy [4]. We discuss the differences and similarities of these derivations.