Miracle-dz/UniFAR-FTUs huggingface dataset:
The field of definition of dynamical systems on P

An economical, durable and easily installed flexible sleeve for disposition at an opening in a structural member through which an operator's control lever extends serves to seal the opening against dust and fumes and further serves to suppress noise transmission through the opening, without restricting necessary movement of the lever. The sleeve is formed of a flexible sheet of material which has a base edge and side edges extending from opposite ends of the base edge in convergent relationship. The sheet material is shaped to define a funnel shaped sleeve wherein the side edges are juxtaposed and joinable by a fabric closure or the like. The sleeve then has a small diameter apex through which the control lever extends and has a larger diameter base portion with outwardly extending tabs which are provided with relatively stiff flat reinforcement for disposition against the structural member around the opening. The apex portion is partially collapsed towards the structural member to create irregular folds and pleats and is clamped to the control lever.
Building power-ful health systems: the impacts of electrification on health outcomes in LMICs

ABSTRACT Critical disparities threaten health care in developing countries and hinder progress towards global development commitments. Almost a billion people and thousands of public services are not yet connected to electricity – a majority in sub-Saharan Africa. In economically fragile settings, clinics and health services struggle to gain and maintain their access to the most basic energy infrastructure. Less than 30% of health facilities in LMICs report access to reliable energy sources, truncating health outcomes and endangering patients in critical conditions. While ‘universal health coverage’ and ‘sustainable energy for all’ are two distinct SDGs with their respective targets, this review challenges their disconnect and inspects their interdependence in LMICs. To evaluate the impact of electrification on healthcare facilities in LMICs, this systematic review analysed relevant publications up to March 2021, using MEDLINE, Embase, Scopus, CENTRAL, clinicaltrials.gov and CINAHL. Outcomes captured were in accordance with the WHO HHFA modules. A total of 5083 studies were identified, 12 fulfilled the inclusion criteria of this review – most were from Africa, with the exception of two studies from India and one from Fiji. Electrification was associated with improvements in the quality of antenatal care services, vaccination rates, emergency capabilities and primary health services; with many facilities reporting high-quality, reliable and continuous oxygen supplies, refrigeration and enhanced medical supply chains. Renewable energy sources were considered in six of the included studies, most highlighting their suitability for rural health facilities. Notably, solar-powered oxygen delivery systems reduced childhood mortality and length of hospital stay. Unavailable and unreliable electricity is a bottleneck to health service delivery in LMICs. Electrification was associated with increased service availability, readiness and quality of care – especially for women, children and those under critical care. This study indicates that stable and clean electrification allows new heights in achieving SDG 3 and SDG7 in LMICs.
In Vivo Transcranial Acoustoelectric Brain Imaging of Different Steady-State Visual Stimulation Paradigms

Objective: Based on the acoustoelectric (AE) effect, transcranial acoustoelectric brain imaging (tABI) is of potential for brain functional imaging with high temporal and spatial resolution. With nonlinear and non-steady-state, brain electrical signal is microvolt level which makes the development of tABI more difficult. This study demonstrates for the first time in vivo tABI of different steady-state visual stimulation paradigms. Method: To obtain different brain activation maps, we designed three steady-state visual stimulation paradigms, including binocular, left eye and right eye stimulations. Then, tABI was implemented with one fixed recording electrode. And, based on decoded signal power spectrum (tABI-power) and correlation coefficient between steady-state visual evoked potential (SSVEP) and decoded signal (tABI-cc) respectively, two imaging methods were investigated. To quantitatively evaluate tABI spatial resolution performance, ECoG was implemented at the same time. Finally, we explored the performance of tABI transient imaging. Results: Decoded AE signal of activation region is consistent with SSVEP in both time and frequency domains, while that of the nonactivated region is noise. Besides, with transcranial measurement, tABI has a millimeter-level spatial resolution (< 3mm). Meanwhile, it can achieve millisecond-level (125ms) transient brain activity imaging. Conclusion: Experiment results validate tABI can realize brain functional imaging under complex paradigms and is expected to develop into a brain functional imaging method with high spatiotemporal resolution.
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Abstract Purpose: We hypothesized that inhibition and trapping of PARP1 alone would be sufficient to achieve antitumor activity. In particular, we aimed to achieve selectivity over PARP2, which has been shown to play a role in the survival of hematopoietic/stem progenitor cells in animal models. We developed AZD5305 with the aim of achieving improved clinical efficacy and wider therapeutic window. This next-generation PARP inhibitor (PARPi) could provide a paradigm shift in clinical outcomes achieved by first-generation PARPi, particularly in combination. Experimental Design: AZD5305 was tested in vitro for PARylation inhibition, PARP-DNA trapping, and antiproliferative abilities. In vivo efficacy was determined in mouse xenograft and PDX models. The potential for hematologic toxicity was evaluated in rat models, as monotherapy and combination. Results: AZD5305 is a highly potent and selective inhibitor of PARP1 with 500-fold selectivity for PARP1 over PARP2. AZD5305 inhibits growth in cells with deficiencies in DNA repair, with minimal/no effects in other cells. Unlike first-generation PARPi, AZD5305 has minimal effects on hematologic parameters in a rat pre-clinical model at predicted clinically efficacious exposures. Animal models treated with AZD5305 at doses ≥0.1 mg/kg once daily achieved greater depth of tumor regression compared to olaparib 100 mg/kg once daily, and longer duration of response. Conclusions: AZD5305 potently and selectively inhibits PARP1 resulting in excellent antiproliferative activity and unprecedented selectivity for DNA repair deficient versus proficient cells. These data confirm the hypothesis that targeting only PARP1 can retain the therapeutic benefit of nonselective PARPi, while reducing potential for hematotoxicity. AZD5305 is currently in phase I trials (NCT04644068).
Self-reported neck and back pain among supermarket cashiers in Gaborone, Botswana

Objective . This study aimed to investigate the prevalence, risk factors and impacts of neck and back pain among supermarket cashiers in Botswana. Results. A total of 174 supermarket cashiers participated in this study, the majority of whom were females (72%). The prevalence of lower back pain was 69%, upper back pain 53% and neck pain 37%. Increasing age was associated with neck (95% confidence interval [CI] [1.43, 5.15]) and upper back (95% CI [1.43, 3.60]) pain. Cashiers working at a low work surface and overreaching for items were 19 and 11 times more likely to report neck (95% CI [1.7, 255.9]) and lower back (95% CI [1.84, 62.1]) pain, respectively. Almost 6% of cashiers who reported lower back pain reported considering changing jobs due to pain. Conclusions. More than two-thirds, one-half and about two-fifths of supermarket cashiers reported lower back, upper back and neck pain, respectively. Individual and work-related factors were associated with neck and/or back pain. To reduce their prevalence and progression, supermarkets should introduce occupational health and safety talks.
COVID‐19 related distress and sleep health among trauma‐exposed South Asians: Does generational status matter?

Abstract The COVID‐19 pandemic has resulted in substantial changes in individual and socio‐economic factors that may negatively impact sleep health. We examined associations between COVID‐19 related distress and sleep among trauma‐exposed South Asian adults in the United States. Since a health advantage among foreign‐born individuals has been previously noted in the literature (the ‘immigrant paradox’), we also explored if generational status (number of generations one's family has been in the U.S.) moderated associations between COVID‐19 related distress and sleep health. Participants were 196 trauma‐exposed South Asian adults residing in the U.S. (54% male, 63% U.S.‐born citizens, average age = 34.51 years), who completed measures of generational status, COVID‐19 related distress, trauma exposure, sleep‐related impairment (SRI), and sleep disturbances. Greater COVID‐19 distress was associated with more sleep disturbances (b = 0.15, p < 0.001) and SRI (b = 0.24, p < 0.001). Generational status was not associated with sleep, nor did it modify associations between COVID‐19 distress and sleep. Findings highlight the potential importance of developing interventions to reduce stress and sleep difficulties during the pandemic. Our results did not support the immigration paradox. Future studies are needed to better understand the role of generational status on sleep health across immigrant subgroups.
Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice

The intersection between immunology and metabolism contributes to the pathogenesis of obesity‐associated metabolic diseases as well as molecular control of inflammatory responses. The metabolite itaconate and the cell‐permeable derivatives have robust anti‐inflammatory effects; therefore, it is hypothesized that cis‐aconitate decarboxylase (Acod1)‐produced itaconate has a protective, anti‐inflammatory effect during diet‐induced obesity and metabolic disease.
Finding agency in limbo: A qualitative investigation into the impact of occupational engagement on the mental health and wellbeing of asylum seekers in the UK

The process of seeking asylum is complex and often leads to extended periods of uncertainty and liminality for people awaiting decisions on their status. Occupational engagement—defined as meaningful activities and roles that bring purpose and agency to one's life—may be a key driver for mental health recovery for marginalized populations, including asylum seekers with traumatic experiences pre- and post-migration. This study aimed to clarify how occupational engagement impacts on mental health and wellbeing and how asylum seekers maintain engagement in occupation in the context of socio-political constraints of the asylum process. We explored the occupational experiences of 12 clients of one human-rights charity, utilizing community-based participatory research methods. Participants completed group mapping sessions where they depicted routine journeys taken to perform occupations in London, which included discussion around the significance of their journeys. Four participants also completed additional “walking maps”—semi-structured interviews which occurred along a selected “occupational journey” they identified as meaningful to their wellbeing. All data were analyzed using thematic network analysis. Findings revealed that engagement in routine occupations within safe, social spaces positively affects the mental wellbeing of asylum seekers by promoting competence, agency, and feelings of belonging. The liminal space of the asylum process meant that participants’ occupational engagement was limited to ‘leisure’ activities but was still critical to establishing forms of agency associated with their wellbeing. Implications for programs and interventions responding to the needs of asylum seekers are discussed.
Patient-reported factors associated with avoidance of in-person care during the COVID-19 pandemic: Results from a national survey

Background There has been a substantial decline in in-person care in inpatient and outpatient settings during the ongoing COVID-19 pandemic. Avoidance of needed in-person care may contribute to an avoidable decline in patient health and an increase in mortality. While several systems and behavioral theories have been put forward to explain the decline, there is a lack of studies informed by patients’ own experiences. The current study applied a socio-ecological model encompassing patient, environmental, and institutional-related variables to examine patient-reported factors associated with avoidance of in-person care. Methods Between October and December 2020, a total of 3840 persons responded to a nationwide online questionnaire that was administered using ResearchMatch and Facebook. Self-reported avoidance of in-person care among those who needed it was the main outcome. Multivariable logistic regression analysis was used to identify factors associated with avoidance of needed care. Findings Out of a total of 3372 respondents who reported that they needed in-person care during the early phase of the pandemic, 257 (7.6%) avoided it. Patient-related variables associated with avoiding needed care included younger age (odds ratio (OR), 1.46, 95% CI 1.11 to 1.94, p<0.01; <45 y/o vs 45+), inability to afford care (OR = 1.65, 95% CI 1.17 to 2.34, p<0.01), and greater COVID-related stress (OR = 1.36, CI 1.01 to 1.83, p<0.05). More frequent discussions about COVID with family and friends was the only significant environment-related avoidance of care variable (OR = 1.39, 95% CI 1.01–1.91, p < .05). Institution-related care avoidance variables included a negative patient healthcare experience rating (OR 1.83, 95% CI 1.38 to 2.42, p<0.001), poor awareness of the institution’s safety protocol (OR = 1.79, 95% CI 1.28 to 2.51, p<0.01), and low ratings of the institution’s effectiveness in communicating their safety protocol (OR = 3.45, 95% CI 1.94 to 6.12, p<0.001). The final model predicted 11.9% of the variance in care avoidance. Conclusions These results suggest that care avoidance of in-person care during the initial phase of the pandemic was influenced by a patient’s demographics as well as environmental and healthcare institutional factors. Patients’ previous experiences and their awareness of healthcare systems’ safety protocols are important factors in care avoidance.
The impact of oxidative stress on reproduction - a focus on gametogenesis and fertilization.

This article lays out the fundamental principles of oxidative stress. It describes the nature of reactive oxygen species (ROS), the way in which these potentially toxic metabolites interact with cells and how they impact both cellular function and genetic integrity. The mechanisms by which ROS generation is enhanced to the point that the cells' antioxidant defence mechanisms are overwhelmed are also reviewed taking examples from both the male and female reproductive system, with a focus on gametogenesis and fertilization. The important role of external factors in exacerbating oxidative stress and impairing reproductive competence is also examined in terms of their ability to disrupt the physiological redox regulation of reproductive processes. Developing diagnostic and therapeutic strategies to cope with oxidative stress within the reproductive system will depend on the development of a deeper understanding of the nature, source, magnitude, and location of such stress in order to fashion personalized treatments that meet a given patient's clinical needs.
Sleep disturbance is a common feature of Kabuki syndrome

Kabuki syndrome (KS) is a rare epigenetic disorder caused by heterozygous loss of function variants in either KMT2D (90%) or KDM6A (10%), both involved in regulation of histone methylation. While sleep disturbance in other Mendelian disorders of the epigenetic machinery has been reported, no study has been conducted on sleep in KS. This study assessed sleep in 59 participants with KS using a validated sleep questionnaire. Participants ranged in age from 4 to 43 years old with 86% of participants having a pathogenic variant in KMT2D. In addition, data on adaptive function, behavior, anxiety, and quality of life were collected using their respective questionnaires. Some form of sleep issue was present in 71% of participants, with night‐waking, daytime sleepiness, and sleep onset delay being the most prevalent. Sleep dysfunction was positively correlated with maladaptive behaviors, anxiety levels, and decreasing quality of life. Sleep issues were not correlated with adaptive function. This study establishes sleep disturbance as a common feature of KS. Quantitative sleep measures may be a useful outcome measure for clinical trials in KS. Further, clinicians caring for those with KS should consider sleep dysfunction as an important feature that impacts overall health and well being in these patients.
Intergroup attitudes and contact between Spanish and immigrant-background adolescents using network analysis

This study aimed to analyze the relationship among different evaluative reactions of the intergroup attitudes and contact in Spanish adolescents evaluating different ethnic minorities and in immigrant-background adolescents evaluating Spanish youth. This study was based on psychosocial models of great impact in the study of intergroup relations such as the Stereotype Content Model and the Behaviors from Intergroup Affect and Stereotypes Map, and incorporated a new approach to the study of attitudes: psychological networks. In total, 1122 Spanish adolescents and 683 adolescents with an immigrant background (Moroccan, Romanian or Ecuadorian origin) participated in the study, aged from 12 to 19 years. They answered a questionnaire with measures of stereotype dimensions (morality, immorality, sociability and competence), emotions (positives and negative), behavioral tendencies (facilitation and harm) and contact (quantity and quality). The results show similar structural patterns in the six studied groups, with emotions acting as links between stereotypes and behavioral tendencies. Moreover, positive and negative stereotype dimensions appeared as independent dimensions that were part of different processes: sociability and morality, and competence to a lesser extent, were related to facilitation behaviors through positive emotions, while immorality was related to harm behaviors through negative emotions. This could indicate that, to achieve successful intergroup relations involving cooperation and the development of friendly relationships, it would be appropriate to intervene in parallel in these two pathways. Due to the centrality of positive emotions (and sociability and immorality) and, therefore, their capacity to affect the entire network, focusing interventions on these variables could be an appropriate strategy to achieve overall positive attitudes.
Meditation reduces brain activity in the default mode network in children with active cancer and survivors

Mounting evidence demonstrates that meditation can lower pain and emotional distress in adults, and more recently, in children. Children may benefit from meditation given its accessibility across a variety of settings (e.g., surgical preparation). Recent neuroimaging studies in adults suggest that meditation techniques are neurobiologically distinct from other forms of emotion regulation, such as distraction, that rely on prefrontal control mechanisms, which are underdeveloped in youth. Rather, meditation techniques may not rely on “top‐down” prefrontal control and may therefore be utilized across the lifespan.
Toward the Fourth Industrial Revolution among E7 Economies: Assessment of the Combined Impact of Institutional Quality, Bank Funding, and Foreign Direct Investment

Technological innovation and its paradigm, that is, the Fourth Industrial Revolution-4IR, have shown strong impact on income levels of adopters across the globe. To this end, this analysis examines the impact of bank funding and institutional quality on technological advancement. This study adds additional variables such as high-technology exports and foreign direct investment (FDI) as control variable. Our study period spans from 2000 to 2018 on an annual frequency for E7 economies (Brazil, Indonesia, Mexico, India, Turkey, Russia, and China). This study leverages on cross-sectional ARDL, Augmented Mean Group (AMG), and Common Correlated Effects Mean Group Estimates (CCEMG) estimation techniques to examine long-run relationship between the outlined variables. Empirical findings show that institution quality, bank finance, income, high-technology exports, and foreign direct investments exert a positive effect on advancements in technology. Furthermore, the interaction between bank finance and institution quality on technological advancement is also positive and statistically significant. Based on the findings, it is concluded that large-scale funding is crucial for businesses to leverage revolutionary technology. Likewise, access to large capital sources if made easier encourages technology affordance as well as innovation and operational excellence. Thus, economies with established legal and financial systems stand to offer businesses such security, which encourages business innovation. Consequently, E7 economies ought to improve their financial and legal systems to boost financial security, creativity, and competitiveness of businesses.
Quantitative Analysis of Vertical Transmission of Maternal SARS-CoV-2 Antibodies to Neonates and Young Infants Following Immunization During Pregnancy

Abstract Serum antibody levels to SARS-CoV-2 in infants born to mothers who had received 2 doses of the BNT2b2 vaccine during pregnancy correlated positively with increasing gestational age at vaccination (P < .01) and negatively with increasing time from vaccination (P < .01), with a significant drop in infants aged >60 days (P = .045).
Hypersonic waverider analysis - A comparison of numerical and experimental results

In this study two waverider configurations are analyzed numerically and experimentally. The geometries are designed using an inverse design and optimization code with the optimization procedure driven by maximized L/D and limited by geometric constraints. Euler and Navier-Stokes numerical simulations are performed with a partially flux-split finite-difference code developed at NASA Ames, F3D. Experimental data is obtained at NASA Langley in the Unitary Plan Wind Tunnel (UPWT) and the 20-Inch Mach 6 wind tunnel for flow visualization, force/moment, and surface pressure measurements at both on- and off-design conditions. Euler simulations are compared with analytic results obtained from conical flow theory, and Navier-Stokes simulations are compared with experimental results both qualitatively and quantitatively for on- and off-design conditions.