Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression

Understanding the molecular basis of major depression is critical for identifying new potential biomarkers and drug targets to alleviate its burden on society. Leveraging available GWAS data and functional genomic tools to assess regulatory variation could help explain the role of major depression-associated genetic variants in disease pathogenesis. We have conducted a fine-mapping analysis of genetic variants associated with major depression and applied a pipeline focused on gene expression regulation by using two complementary approaches: cis-eQTL colocalization analysis and alteration of transcription factor binding sites. The fine-mapping process uncovered putative causally associated variants whose proximal genes were linked with major depression pathophysiology. Four colocalizing genetic variants altered the expression of five genes, highlighting the role of SLC12A5 in neuronal chlorine homeostasis and MYRF in nervous system myelination and oligodendrocyte differentiation. The transcription factor binding analysis revealed the potential role of rs62259947 in modulating P4HTM expression by altering the YY1 binding site, altogether regulating hypoxia response. Overall, our pipeline could prioritize putative causal genetic variants in major depression. More importantly, it can be applied when only index genetic variants are available. Finally, the presented approach enabled the proposal of mechanistic hypotheses of these genetic variants and their role in disease pathogenesis.
You’ve got mail: how the Trump administration used legislative communication to frame his last year in office

ABSTRACT Legislative communication frames how constituents perceive politicians’ successes. However, most research on legislative communication focuses on Congressional or Senatorial email correspondence, without considering the importance of presidential emails or the way politicians frame their failures. Existing work on legislative communication also tends to analyze the documents in isolation, leaving open the opportunity to analyze the networked effect of information flows. To fill this gap, we analyze a year of 1600 Daily content – The Official White House email style newsletter created by the Obama Administration and subsequently adopted after the Trump administration took office. In doing so, we identify the central frames the Trump White House relied on leading up to the 2020 election and the media sources used to legitimize these claims. Drawing on frequency counts, structural topic modeling, and qualitative content analysis, our data reveal the important role electoral communication plays in framing current events and the extent to which email is an essential node in the right-wing media ecosystem.
Channel Mobility Boosting in a Poly-Si Channel Using Ge Diffusion Engineering and Hydrogen Plasma Treatment

We demonstrated that channel mobility and cell current could be increased through Ge diffusion engineering and H2 plasma treatment in a poly-Si channel. Even though the Ge channel has a higher intrinsic mobility than the Si channel, a typical poly-SiGe channel has inferior channel characteristics due to high interface trap density (Dit) and bulk trap density caused by Ge. We propose a novel technique to control the Ge profile along the depth direction of the channel to realize lower Ge concentration at the gate dielectric interface and higher Ge concentration at the channel bulk. This Ge profile could achieve reduced Dit and enhanced channel mobility. Furthermore, the bulk traps caused by Ge are effectively reduced by H2 plasma treatment. These techniques increased the channel mobility to 32%, which can help increase the channel mobility of devices where poly-Si channels are used.
Intrascleral Knotless Zigzag Suture Fixation of Four-Haptic Hydrophilic Acrylic Foldable IOL: Clinical Outcomes

Background The main options for intraocular lens (IOL) placement without capsular bag support and/or zonular weakness are iris-fixated IOL and scleral-fixated IOL (SFIOL). Purpose To describe the surgical technique and the outcomes of intrascleral knotless zigzag suture fixation of Akreos AO60 foldable IOL. Methods Retrospective cohort study of consecutive cases. Results Ninety-nine eyes of 92 patients were retrospectively studied. The mean age was 72.1±15.2 years (range 18–94), and the median follow-up duration was 19.5 months (range 3–81). The best-corrected visual acuity improved from a mean±SD of 1.34±0.70 logarithm of the minimum angle of resolution (logMAR) units at baseline to 0.49±0.56 logMAR at the end of follow-up (p<0.001). The mean±SD final SE was −1.24±1.82 diopters. The mean±SD prediction error was −0.51±1.16 diopters. The overall perioperative complications rate was 44.4% (n=44). The rate of complications requiring invasive treatment was 19.2% (n=19). The most common perioperative complications were ocular hypertension (OHT, 20.2%, n=20), and cystoid macular edema (CME, 15.2%, n=15). The rate of IOL dislocation was 7% (n=7). Conclusion This knotless technique avoids the risks of haptics fixation but is more prone to IOL dislocation in cases of suture deterioration. Past ophthalmic history needs to be carefully considered in candidates who underwent SFIOL implantation.
No evidence for trait- and state-level urgency moderating the daily association between negative affect and subsequent alcohol use in two college samples

It remains unclear whether the negative reinforcement pathway to problematic drinking exists, and if so, for whom. One idea that has received some support recently is that people who tend to act impulsively in response to negative emotions (i.e. people high in negative urgency) may specifically respond to negative affect with increased alcohol consumption. We tested this idea in a preregistered secondary data analysis of two ecological momentary assessment studies using college samples. Participants (N = 226) reported on their current affective state multiple times per day and also the following morning reported alcohol use of the previous night. We assessed urgency both at baseline and during the momentary affect assessments. Results from our Bayesian model comparison procedure, which penalises increasing model complexity, indicate that no combination of the variables of interest (negative affect, urgency, and the respective interactions) outperformed a baseline model that included two known demographic predictors of alcohol use. A non-preregistered exploratory analysis provided some evidence for the effect of daily positive affect, positive urgency, as well as their interaction on subsequent alcohol use. Taken together, our results suggest that college students’ drinking may be better described by a positive rather than negative reinforcement cycle.
Removal of phenolic compounds from olive oil mill wastewater using kaolinite and iron oxide nanoparticles

In this study, effective, inexpensive, sustainable, and environmentally friendly adsorbents composed of iron oxide nanoparticles immobilized on kaolinite were used to remove phenolic compounds from olive mill wastewater (OMW) in Jordan. Two phenolic compounds (tyrosol and p-hydroxybenzoic acid) were selected as models for phenols present in OMW. The best adsorbent was acid-activated kaolinite mixed with iron oxide nanoparticles with a ratio of 1:20. This mixture gave removal efficiencies up to 81.8% and 97.3% for tyrosol and p-hydroxybenzoic acid, respectively. Investigation of adsorption at different conditions showed that the best adsorption was at pH of 3, a temperature of 25°C, an adsorbent dose of 2.5 g/100 mL OMW, and the equilibrium was established after 3 h. Also, a new efficient high-performance liquid chromatography (HPLC-UV) method was developed for the determination of the target phenolic compounds in OMW. The new method showed satisfactory validation results in terms of linearity, precision, recovery, the limit of detection and limit of quantitation.
What Is Distinctive about the Sexual Victimization of Female Adolescents? A Comparison with the Sexual Victimization of Children and Adults

ABSTRACT This study examines the characteristics of the sexual victimization of adolescents and provides a comparison with the ones of children and adults. The sample includes 2,665 sexual abuse cases of female children, adolescents, and adults in France. Analyses revealed differential patterns in factors associated with the sexual victimization of adolescents. Findings suggest that the sexual victimization of adolescents may be located along a continuum in terms of sexuality, antisociality, and situational factors, between children and adult victimization. Implications for the prevention of the victimization of adolescents, clinical considerations for offenders, and avenues for future research are discussed.
Understanding Millennials’ nature-based tourism experience through their perceptions of technology use and travel constraints

ABSTRACT This study aims to understand millennials’ nature-based tourism experience through their perceptions towards technology use and travel constraints in a nature-based tourism context by drawing upon technology escape and digital-free travel conceptualizations and leisure constraints theory. Data were collected using surveys from 276 millennials and nature-based tourism providers, and two focus groups consisting of 21 providers and 13 millennials. The findings revealed that millennials perceived laptops with WI-FI access, virtual/ augmented reality, digital cameras, and WI-FI access at campsites to be significantly less enhancing of the nature-based tourism experience compared to the providers’ perceptions. An exploratory factor analysis identified four dimensions of travel constraints among millennials, including intrapersonal, interpersonal, time, and destination attributes. The findings highlight millennials’ conflicting need to escape from day-to-day technology use while remaining connected to basic technology services. Both the theoretical contributions of these findings and practical implications are discussed.
Long-Term Efficacy of Pallidal Deep Brain Stimulation in a Patient with DYT-THAP1 (DYT-6) Dystonia from India

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Risk assessment for foot ulceration in a nigerian diabetic population attending university of Ilorin teaching hospital, Ilorin

Background: Complications from diabetic foot ulcer often pose a strong threat to the life of patients with diabetes. The aim of this study was to evaluate the risk factors for foot ulceration among people living with diabetes attending University of Ilorin Teaching Hospital, Ilorin, Nigeria. Materials and Methods: One hundred and fifty-one diabetic patients were interviewed with a questionnaire to obtain their sociodemographic, foot care, and diabetes-related details. Both of their feet were then assessed for dermatological changes, musculoskeletal deformities, neurological and vascular complications. Risk stratification was done according to the diabetic foot risk classification system of the International Working Group on Diabetic Foot. Data were analyzed using SPSS version 22. Categorical variables were compared using the Chi-square test while correlation between the risk categories and patients' characteristics was determined using Pearson's Correlation Coefficient, setting statistical significance at P < 0.05. Results and Conclusion: Intermittent claudication was found in 40 patients (26.5%), 76 (50.3) had paresthesia. Eighty nine (58.9%) had foot care education but only 7 (4.6%) had special diabetic foot wears. Impaired monofilament sensitivity was seen in 27 (17.9%) of the right feet and in 23 (15.2%) of the left feet. Significant peripheral neuropathy was detected in 36 (23.9%) on the right and 30 (19.9%) on the left side. It was found that the longer the duration of diabetes, the higher the risk (P = 0.04). Furthermore, patients who had no education had significantly higher risk for diabetes foot ulcer (DFU) (P = 0.01). High risk was discovered among the retirees (P = 0.01). In addition, presence of kidney disease (P = 0.046), cardiovascular disease (P = 0.001), and visual impairment (P = 0.19) all conferred a high risk for developing DFU in our study population. Overall assessment showed that the prevalence of “foot-at-risk' in this study was 30.5% which we think is substantial enough to attract a more serious attention.
Adapting the UTAUT2 Model for Social Commerce Context

Social commerce (SC) became a major channel for conducting business as a result of the ban adopted by many countries because of Covid-19 era. The simplicity of the Unified Theory of Acceptance and use of Technology (UTAUT) and its extended version (UTAUT2) invites researchers to explore other options that can yield better explanation of the adoption of SC. This study extended the UTAUT2 with perceived value, trust and a SC related construct. In addition, the study re-structured the UTAUT2 to fit with SC environment. The study utilized 463 surveys distributed in Qatar, and analyzed the data using SEM. Results fully supported the proposed model, where trust, perceived value, facilitating conditions, and hedonic motivation significantly predicted behavioral intentions with an R2 value equal to 72%. The model supported the role of performance expectancy and SC constructs in predicting perceived value, and the role of effort expectancy and habit in predicting hedonic motivation.
Therapeutic itinerary of patients with chronic low-back pain attending outpatient physiotherapy clinic

Objective: to assess therapeutic itinerary of patients with chronic low-back pain. Methods: qualitative study involving the use of an in-depth semi structured interviews were used to collect data on therapeutic itinerary among ten patients with chronic low-back pain who from physiotherapy clinic of a tertiary hospital. Data was analysed using thematic content analysis. Results: emerging themes were as follows: onset of low-back pain, symptoms that initiated the journey for care, steps taken to find pain relief, respondent’s perception on care received, interference of chronic low-back pain with normal life, family and relations, multiple practices in which chronic low-back pain patients are involved, perception of effectiveness of the multiple practices, and hurdles to seeking care. Conclusion: patients with chronic low-back pain take different routes in search of care. Chronic low-back pain markedly altered patients’ life and made them prone to practicing medical pluralism.
Particle properties

The standard model of particle physics classifies particles into elementary leptons and hadrons composed of quarks. There exists an alternate ordering principle based on a function Ψ that may be derived from the framework of the Einstein field equations, giving a convergent series of particle energies to be quantized as a function of the fine-structure constant, α, with limits given by the energy values of the electron and the Higgs vacuum expectation value. The series expansion of the energy equation provides quantitative terms for Coulomb, strong and gravitational interaction. The value of α can be given numerically by the gamma functions of the integrals involved, extending the formalism to N-dimensions yields a single expression for the electroweak coupling constants. Preliminary results for other particle properties such as magnetic moment, decay channels or scattering features exist. Necessary input parameters for all calculations can be reduced to elementary charge and electric constant in natural units.
Impact of Arbuscular Mycorrhiza on Uptake, Growth, Yield and Water Relations of
Vegetable Plants Subjected To Drought Stress: A Review

The need of cultivation expansion in the new reclaimed lands in desert areas requires application of certain practices that could be sustainable for such arid regions. Vegetable plants, in general, are seriously affected by severe drought or even a slight shortage of irrigation water and subsequently their growth, productivity and quality are markedly reduced. Most of vegetable plants can be considered as a host for arbuscular mycorrhizal. As a result of mycorrhizal inoculation, the beneficial effects on vegetables include improving absorption of water and nutrients and enhance tolerance of various environmental stresses including drought. However, this article will focus on the effects of arbuscular mycorrhiza (A mycorrzia) on growth, productivity, uptake and water relations of vegetable plants under drought stress conditions.
Mind the Machines: Applying Implicit Measures of Mind Perception to Social Robotics

Beyond conscious beliefs and goals, automatic cog-nitive processes shape our social encounters, and interactions with complex machines like social robots are no exception. With this in mind, it is surprising that research in human-robot interaction (HRI) almost exclusively uses explicit measures, such as subjective ratings and questionnaires, to assess human attitudes towards robots - seemingly ignoring the importance of implicit measures. This is particularly true for research focusing on the question whether or not humans are willing to attribute complex mental states (i.e., mind perception), such as agency (i.e., the capacity to plan and act) and experience (i.e., the capacity to sense and feel), to robotic agents. In the current study, we (i) created the mind perception implicit association test (MP-IAT) to examine subconscious attributions of mental capacities to agents of different degrees of human-likeness (here: human vs. humanoid robot), and (ii) compared the outcomes of the MP-IAT to explicit mind perception ratings of the same agents. Results indicate that (i) already at the subconscious level, robots are associated with lower levels of agency and experience compared to humans, and that (ii) implicit and explicit measures of mind perception are not significantly correlated. This suggests that mind perception (i) has an implicit component that can be measured using implicit tests like the IAT and (ii) might be difficult to modulate via design or experimental procedures due to its fast-acting, automatic nature.
Impact of COVID-19 Pandemic on the Self-Reported Frequency of Hospital Visits and Pediatric Care Outcomes in the Kingdom of Saudi Arabia

Introduction Coronavirus disease 2019 (COVID-19) pandemic has influenced various aspects of health care and its outcomes. Several studies conducted on different age groups from different countries have reported a decrease in the frequency of hospital visits during the pandemic. Aim This study aimed to assess the self-reported effect of the COVID-19 pandemic on hospital visits and healthcare outcomes in the pediatric age group. We further aimed to assess the participants’ beliefs on the reasons for decreased frequency of hospital visits during the pandemic. Methods This was a quantitative analytical cross-sectional study. Data from the parents of children less than 14 years living in the Kingdom of Saudi Arabia (KSA) was collected using a self-administered structured questionnaire. The questionnaire included sociodemographic characteristics of the participants, self-reported frequency of hospital visits, and potential consequences on pediatric care outcomes during the pandemic. A total of 1,548 initial respondents filled the questionnaire, out of which only 1,311 had children aged less than 14 years. SPSS version 25 (IBM, New York, USA) was used for statistical analysis. Results We found that of the 1,311 eligible respondents, majority (75.1%) were mothers of the children while only 24.9% were fathers, and 34.4% of the respondents had two children less than 14 years. Majority (76.7%) of the respondents were from the central region and felt that the pandemic has reduced their frequency of hospital visits. Furthermore, majority (78.6%) of the respondents believed that the decreased hospital (emergency or clinic) visits did not have any negative effect on the health and care of their children. Moreover, 56.4% of the participants responded that lack of the need to visit the hospital during the pandemic was the reason for their decreased hospital visits frequency, and 51.6% were afraid of being infected by the virus. There was a significant association between decreased hospital visits and missing an appointment for vaccination, delayed diagnosis, deterioration of participants’ children’s condition, and running out of treatment and inability to refill. Conclusion This study was conducted to assess the impact of the COVID-19 pandemic on hospital visits and pediatric care outcomes in the KSA. We hypothesized that the pandemic has led to a reduction in pediatric hospital visits which might influence pediatric care outcomes. We found that there was a decrease in the frequency of hospital visits. This decrease was attributed to the lack of the need to go to the hospital or to the fear of being infected by the virus. A significant association was found between the participants’ beliefs of the pandemic effect on hospital visits and its effect on the pediatric care outcomes.