Miracle-dz/UniFAR-FTUs huggingface dataset:
A Numerical Study on the Effect of Tool Speeds on Temperatures and Material Flow Behaviour in Refill Friction Stir Spot Welding of Thin AA7075-T6 Sheets

A three-dimensional (3D) numerical model was created to simulate and analyze the effect of tool rotational speeds (RS) and plunge rate (PR) on refill friction stir spot welding (refill FSSW) of AA7075-T6 sheets. The numerical model was validated by comparing the temperatures recorded at a subset of locations with those recorded at the exact locations in prior experimental studies from the literature. The peak temperature at the weld center obtained from the numerical model differed by an error of 2.2%. The results showed that with the rise in RS, there was an increase in weld temperatures, effective strains, and time-averaged material flow velocities. With the rise in PR, the temperatures and effective strains were reduced. Material movement in the stir zone (SZ) was improved with the increment of RS. With the rise in PR, the top sheet’s material flow was improved, and the bottom sheet’s material flow was reduced. A deep understanding of the effect of tool RS and PR on refill FSSW joint strength were achieved by correlating the thermal cycles and material flow velocity results obtained from the numerical models to the lap shear strength (LSS) from the literature.
Revisions to "Transport solution for SCH QW laser diodes"

The solutions to the charge and current transport equations are considered for the quantum-well laser diode. The electric field is calculated as a function of position in the i-region with the total injected current J as a parameter and inclusion of both hole and electron components. The time constant corresponding to the resistance and capacitance of the i-region is shown to agree with earlier predictions by others for the low-frequency dependence of the laser response. The frequency dependence of the electrical confinement factor must also be considered in assessing the low-frequency response.
Shape factors, two‐flow models, and the problem of irradiance inversion in estimating optical parameters

The problem of the inversion of irradiance measurements for the inherent optical properties of a hydrosol such as the world ocean has been examined with the NOARL optical model. This model is a Monte Carlo simulation of the radiative transfer equation that, given the optical properties of a hydrosol, generates the zonal radiances and the commonly measured irradiances of that hydrosol. This information allows us to test the optical inversion capability of any irradiance model. We have demonstrated that the two‐flow model, used often in atmospheric optics, cannot be inverted to yield the inherent backscatter coefficient of natural hydrosols due to the extreme asymmetry of the hydrosol volume scattering function. The asymmetry of the volume scattering function interacting with the radiance distribution introduces parameters called shape factors into the models for irradiance inversion. The presence of shape factors in an irradiance model renders it unsolvable; thus, simplifying assumptions are required for an inverse solution. We inquire into the possibilities for irradiance inversion given the existence of shape factors.
Priming congruence and COVID-19 vaccination intention: a mediation analysis

BACKGROUND This study took place at the height of the fifth wave of COVID-19 in France, coinciding with stigmatizing communication toward the unvaccinated. We hypothesized that adherence to this communication would facilitate or inhibit the effects of priming on vaccination intention, depending on whether the priming included a dimension of connection to others. PARTICIPANTS AND PROCEDURE In a convenience online French sample (N = 1800, M age = 26.30), vaccination intention was asked after love priming, no love/prejudice priming, materialism priming, or a control condition. Participants also reported their adherence to restrictive measures, i.e., media control, vaccination pass, and mandatory vaccination. RESULTS Vaccination intention was higher in the no love/prejudice and materialism conditions than in the love and control conditions. Adherence to restrictive measures mediated the effect of prejudice or materialism priming on intention to get vaccinated. CONCLUSIONS Implications of these results are discussed in light of the socially situated cognition perspective and the congruence of (a) a societal context of communication toward the vaccine and the unvaccinated, (b) the participant’s degree of adherence to that communication, (c) the theme of priming, whether or not related to feeling connected to others. Implications of materialism priming are discussed, and the effect of commitment on intention to get vaccinated.
Completion of Parallel app Software User Operation Sequences Based on Temporal Context

While mobile application (app) software is becoming increasingly important in people's daily lives, researchers have the limitation of understanding the details of user operations inside the app. With the update of the Android system and application user interface, relying on manually defined user operation event templates or modifying the app source code can no longer meet the needs of fine-grained user operation analysis in multiparallel applications. In this article, a novel method is proposed for effectively analyzing user operations in parallel apps based on the temporal context of user operation sequences. The authors provide a general framework in the Android system to parse out fine-grained user operations. In addition, the authors build a deep learning model with LSTM-TextCNN to complete user operations in parallel app from global temporal context and app temporal context. The authors collected 240k operations of 12 users over a month. Comparative experiments with a baseline show that the proposed method can efficiently and accurately analyze parallel app user operations.
Theoretical analysis of modulation response and second-order harmonic distortion in vertical-cavity surface-emitting lasers

A rate-equation model is developed, with the consideration of size effects, to analyze the steady state and dynamic behavior of index-guided vertical-cavity surface-emitting lasers. The size dependence of spatial hole burning, cavity loss, as well as thermal resistance of device cavity are taken into account. Using this model, the influence of size effects on the amplitude modulation response and second-order harmonic distortion are studied. It is found that a laser with a small core radius exhibits better modulation response and less harmonic distortion than that of a large waveguide device, however, there is a tradeoff between the output power and modulation efficiency of the lasers.
The Stokes and Navier-Stokes equations with boundary conditions involving the pressure

This paper is concerned with the stationary Stokes and Navier-Stokes equa tions with non standard boundary conditions: specifically the case where the pres sure is given on some part of the boundary will be considered. To be precise, the flow of a viscous incompressible fluid which occupies a bounded domain of R3 is studied. The velocity u and pressure p are assumed to satisfy in this domain ƒ¶ either the stationary Stokes equations:
A short scale for managerial support to teleworkers

Abstract Compulsory teleworking has affected workers in several countries, increasing concerns about managerial support. This study aimed to build and present validity evidence of the Short Scale for Managerial Support to Teleworkers. We carried out four successive steps, namely: adapting items from other managerial support scales or related constructs to the teleworking context; exploratory factor analysis and network analysis (N=3,769); confirmatory factor analysis (N=3,839); invariance analysis considering gender and education (N=7,608). As a result, the scale has a unifactorial structure with five items and quite favorable psychometric indicators regarding validity, reliability, and invariance. We recommend using the scale applied to different samples of teleworkers and research with other organizational or individual variables.
Newton’s Conceptual Argument for Absolute Space

While many take Newton’s argument for absolute space to be an inference to the best explanation, some argue that Newton is primarily concerned with the proper definition of true motion, rather than with independent existence of spatial points. To an extent the latter interpretation is correct. However, all prior interpretations are mistaken in thinking that ‘absolute motion’ is defined as motion with respect to absolute space. Newton is also using this notion to refer to the quantity of motion (momentum). This reading reveals a misunderstood argument for absolute space, according to which absolute space is necessary for a workable definition of momentum.
Evaluation of deep learning methods for early gastric cancer detection using gastroscopic images

BACKGROUND: A timely diagnosis of early gastric cancer (EGC) can greatly reduce the death rate of patients. However, the manual detection of EGC is a costly and low-accuracy task. The artificial intelligence (AI) method based on deep learning is considered as a potential method to detect EGC. AI methods have outperformed endoscopists in EGC detection, especially with the use of the different region convolutional neural network (RCNN) models recently reported. However, no studies compared the performances of different RCNN series models. OBJECTIVE: This study aimed to compare the performances of different RCNN series models for EGC. METHODS: Three typical RCNN models were used to detect gastric cancer using 3659 gastroscopic images, including 1434 images of EGC: Faster RCNN, Cascade RCNN, and Mask RCNN. RESULTS: The models were evaluated in terms of specificity, accuracy, precision, recall, and AP. Fast RCNN, Cascade RCNN, and Mask RCNN had similar accuracy (0.935, 0.938, and 0.935). The specificity of Cascade RCNN was 0.946, which was slightly higher than 0.908 for Faster RCNN and 0.908 for Mask RCNN. CONCLUSION: Faster RCNN and Mask RCNN place more emphasis on positive detection, and Cascade RCNN places more emphasis on negative detection. These methods based on deep learning were conducive to helping in early cancer diagnosis using endoscopic images.
Detection of the Xanthi Chryso-like Virus in New Geographical Area and a Novel Arthropod Carrier

Here, we report on a serendipitous finding of a chryso-like virus associated with Culex pipiens mosquitos in the course of study aimed to detect and characterize West Nile virus (WNV) circulating in mosquitos in Serbia, Southern Europe. Upon initial detection of unexpected product in a PCR protocol for partial WNV NS5 gene amplification, further confirmation and identification was obtained through additional PCR and Sanger sequencing experiments. Bioinformatic and phylogenetic analysis identified the obtained sequences as Xanthi chryso-like virus (XCLV). The finding is particular for the fact that it associates XCLV with a new potential vector species and documents a novel geographical area of its distribution.
Inference in the presence of weak instruments : a selected survey

Here we present a selected survey in which we attempt to break down the ever burgeoning literature on inference in the presence of weak instruments into issues of estimation, hypothesis testing and confidence interval construction. Within this literature a variety of different approaches have been adopted and one of the contributions of this survey is to examine some of the links between them. The vehicle that we will use to establish these links will be the small concentration results of Poskitt and Skeels (2007), which can be used to characterize various special cases when instruments are weak. We make no attempt to provide an exhaustive survey of all of the literature related to weak instruments. Contributions along these lines can be found in, inter alia , Stock et al. (2002), Dufour (2003), Hahn and Hausman (2003), and Andrews and Stock (2007), and we view this survey as complementary to those earlier works.
Slice of Life: Porcine Kidney Slices for Testing Antifibrotic Drugs in a Transplant Setting

Circulatory death donor (DCD) kidneys are increasingly used to enlarge the donor pool. These kidneys undergo ischemia-reperfusion injury, frequently leading to renal fibrosis. Transforming growth factor beta 1 (TGF-β1) and matrix metalloproteases have been identified as central mediators of fibrosis and inhibition of these targets could attenuate fibrosis. We studied whether galunisertib, doxycycline, taurine, and febuxostat alleviated fibrosis in precision-cut kidney slices (PCKS). PCKS were prepared from porcine kidneys that were exposed to 30 min of warm ischemia followed by 3 h of oxygenated hypothermic machine perfusion. We subsequently incubated PCKS for 48 h at 37 °C with the described compounds. To further elucidate the antifibrotic effects of galunisertib, we cultured PCKS with TGF-β1. We first screened the effects of the compounds without TGF-β1. Most significant effects were observed for galunisertib which lowered the expression of ACTA2, TGFB1, FN2, and SERPINE1. We then investigated the effects of galunisertib in fibrotic PCKS incubated with TGF-β1. TGF-β1 significantly increased expression of TGFB1, FN1, SERPINE1, and SERPINH1. Galunisertib, however, attenuated the expression of all fibrosis-related genes. Galunisertib appears to be a promising antifibrotic compound requiring further research in a preclinical model and may ultimately be administered during machine perfusion as an antifibrotic treatment in a transplant setting.
Flame interactions as a source of noise and combustion instabilities

Mechanisms giving rise to sound emission from flames are analyzed in this article. Using simple experiments on laminar flames it is shown that intense sound emission may originate from flame interactions. In a first case, a premixed laminar flame interacts with a cool plate. The flame movement is initiated by weak perturbations of the flow impinging on the flame from upstream. It is shown that this induces a strong flame motion and an intense emission of sound. Detailed analysis of the signals detected by a far field microphone, a photomultiplier recording the global emission from free radicals and phase conditioned images indicate that acoustic emission is related to the rate of change of the flame surface area. The flame-wall interaction amplifies the sound radiation by about 20 dB over a broad range of frequencies. In a second experiment, the flame is formed on an annular burner and the steady state takes the shape of a fountain. When this flame is submitted to weak acoustic perturbations from upstream it is set into a large amplitude periodic motion. Adjacent flame elements interact strongly inducing cyclic variations of the flame area and corresponding oscillations of heat release. The motion induces an intense emission of sound due to mutual flame annihilation. In the third configuration, an inverted conical flame is stabilized on a central rod. The flame interacts with the shear layer originating from the burner lip. Under low level upstream modulations, the flame executes a periodic motion involving interactions between vortices shed from the burner lip and the reactive front. This induces a rolling up of the front elements at the flame extremities and is accompanied by an intense emission of sound. These three examples indicate that rapid rates of change of flame surface area constitute a strong source of combustion noise, a mechanism which could be the source of much of the noise radiated by turbulent flames. Such interactions may also drive instabilities under resonant conditions.
Agomelatine, a Melatonin-Derived Drug, as a New Strategy for the Treatment of Colorectal Cancer

The potential use of agomelatine as an alternative treatment for colorectal cancer is evaluated in this work. The effect of agomelatine was studied in an in vitro model using two cell lines with different p53 statuses (HCT-116, wild-type p53, and HCT-116 p53 null) and an in vivo xenograft model. The inhibitory effects of agomelatine and melatonin were stronger in the cells harboring the wild-type p53, although in both cell lines, the effect of agomelatine was greater than that of the melatonin. In vivo, only agomelatine was able to reduce the volumes of tumors generated by the HCT-116-p53-null cells. Both treatments induced changes in the rhythmicity of the circadian-clock genes in vitro, albeit with some differences. Agomelatine and melatonin regulated the rhythmicity of Per1-3, Cry1, Sirt1, and Prx1 in the HCT-116 cells. In these cells, agomelatine also regulated Bmal1 and Nr1d2, while melatonin changed the rhythmicity of Clock. In the HCT-116-p53-null cells, agomelatine regulated Per1-3, Cry1, Clock, Nr1d2, Sirt1, and Prx1; however, melatonin only induced changes in Clock, Bmal1, and Sirt1. The differences found in the regulation of the clock genes may explain the greater oncostatic effect of agomelatine in CRC.
Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts

Bromodomain- and extra-terminal domain (BET) proteins are epigenetic reader proteins that regulate transcription of their target genes by binding to acetylated histone side chains. Small molecule inhibitors, such as I-BET151, have anti-inflammatory properties in fibroblast-like synoviocytes (FLS) and in animal models of arthritis. Here, we investigated whether BET inhibition can also affect the levels of histone modifications, a novel mechanism underlying BET protein inhibition. On the one hand, FLSs were treated with I-BET151 (1 µM) for 24 h in absence and presence of TNF. On the other hand, FLSs were washed with PBS after 48 h of I-BET151 treatment, and the effects were measured 5 days after I-BET151 treatment or after an additional 24 h stimulation with TNF (5 d + 24 h). Mass spectrometry analysis indicated that I-BET151 induced profound changes in histone modifications, with a global reduction in acetylation on different histone side chains 5 days after treatment. We confirmed changes on acetylated histone side chains in independent samples by Western blotting. I-BET151 treatment reduced mean TNF-induced levels of total acetylated histone 3 (acH3), H3K18ac, and H3K27ac. In line with these changes, the TNF-induced expression of BET protein target genes was suppressed 5 d after I-BET151 treatment. Our data indicate that BET inhibitors not only prevent the reading of acetylated histones but directly influence overall chromatin organization, in particular after stimulation with TNF.
A Low-Complexity Iterative Message Passing Algorithm for Robust RSS-TOA IoT Localization

This contribution considers the problem of robust target localization using the possibly unreliable hybrid received signal strength and time-of-arrival measurements, in the Internet of Things (IoT) context. Traditional positioning approaches relying on either extra a priori error information for robustification or the computationally intensive convex programming techniques for optimization do not fit well into the IoT applications with limited computing resources. Such concerns, however, will jeopardize the straightforward applicability of many ready-made solutions to the IoT positioning services if left untreated. In this article, the problem is resolved in a different manner. We adopt here a Geman–McClure like loss function, which is much less sensitive to the biased sensor observations, in order to statistically robustify the $\ell _{2}$ -sapce-based location estimator. A computationally attractive iterative message passing algorithm is then developed to conduct efficient optimization. Simulation results demonstrate the performance superiority of the proposed scheme over its competitors in various localization environments.
Dynamics of semiconductor microring lasers subject to on-chip filtered optical feedback

Tunable laser diodes are needed in a range of applications including wavelength division multiplexing, optical instrument testing, optical sensing and tera hertz generation. In this work, we investigate the stability of lasers which use ﬁltered optical feedback for wavelength tuning. We investigate experimentally the dynamics induced by this on-chip ﬁltered optical feedback. In this study, we choose to use a compact device which combines a semiconductor ring laser with on-chip ﬁltered optical feedback to achieve wavelength tunability. The ﬁltered optical feedback is realized by employing two arrayed waveguide gratings to split/recombine light into diﬀerent wavelength channels. Semiconductor optical ampliﬁers are placed in the feedback loop in order to control the feedback of each wavelength channel independently. Experimental observations show that the stability of the clockwise and counterclockwise propagation modes depends on the feedback strength. Experiments also show that for a speciﬁc range of the feedback strength, anti-phase oscillations in the intensity of the clockwise and counterclockwise propagating modes can be induced. These oscillations could not be seen in the same semiconductor ring laser without ﬁltered optical feedback. We investigate how the frequency and the amplitude of these oscillations change under the eﬀect of ﬁltered optical feedback. We also discuss how these anti-phase oscillations can be suppressed by properly choosing the feedback strength.
Form-Dependent Toxicity of Silver Nanomaterials in Rainbow Trout Gills

The toxicity of the form of nanoparticles is presently not well understood. The purpose of this study consists in comparing the toxicity of various forms of silver nanoparticles (nAg) in juvenile rainbow trout Oncorhynchus mykiss. Juveniles were exposed to various forms of polyvinyl-coated nAg of similar size for 96 h at 15 °C. After the exposure period, the gills were isolated and analyzed for Ag uptake/distribution, oxidative stress, glucose metabolism, and genotoxicity. Higher levels of Ag were detected in gills in fish exposed to dissolved Ag followed by spherical, cubic, and prismatic nAg. Size-exclusion chromatography of gill fractions revealed that the dissolution of nAg was observed for all forms of nAg where prismatic nAg released more important levels of Ag in the protein pool as in fish exposed to dissolved Ag as well. The aggregation of nAg was more important for cubic nAg in respect of the other forms of nAg. The data revealed that lipid peroxidation was closely associated with protein aggregation and viscosity. Biomarkers revealed changes in lipid/oxidative stress and genotoxicity, which were related to the loss of protein aggregation and inflammation (NO2 levels), respectively. In general, the observed effects were found for all forms of nAg where the effects from prismatic nAg were generally higher than for spherical and cubic nAg. The strong relationship between genotoxicity and inflammation response suggests the participation of the immune system in the observed responses of juvenile fish gills.