Miracle-dz/UniFAR-FTUs huggingface dataset:
LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

In this study, the attenuative effects of the hydro-alcoholic extract from Mitragyna speciosa (MSE) against diabetes-induced anxiety and depression-like behaviors were examined. In addition, UPLC/ESI/TOF-MS analysis was performed to identify the phytochemical nature of MSE. DM was induced using a combination of high fructose/streptozotocin, and the diabetic rats were treated with MSE (50 and 200 mg/kg) for 5 weeks. After treatment, the animals were subjected to a forced swim test, open field test and elevated plus-maze tests. Additionally, proinflammatory cytokines and oxidative stress parameters were evaluated in the brain tissues of the rats. UPLC/ESI/TOF-MS analysis revealed that MSE is abundantly rich in polyphenolic constituents, notably flavonoid and phenolic glycosides. Behavioral tests and biochemical analyses indicated that diabetic rats showed significantly increased anxiety and depressive-like behavioral deficits, brain oxidative stress and pro-inflammatory cytokines levels (IL-1β, IL-6 and TNF-α). Treatment with MSE (50 and 200 mg/kg) significantly attenuated increased blood glucose level, depressive and anxiety-like behaviors in diabetic rats. Additionally, the antioxidant enzymes activities were markedly increased in MSE-treated animals, while TNF-α, IL-1β and IL-6 cytokines were notably suppressed. Taken together, these results suggested that MSE has potentials as antidepressant and anxiolytic-like effects and improves the brain oxido-inflammatory status in diabetic rats.
Unsteady open channel flow registrations in a test flume with circular cross-section

In the framework of a research project 1996-1998 "Time dependent erosional behaviour of natural sediments in unsteady flow" the equipment of a test flume with circular cross-section was extended to perform measurements under unsteady flow conditions. The experimental setup creates the possibility to gather the necessary information concerning the time evolution of flow and friction characteristics during unsteady flow. A series of triangular hydrographs were passed through the circular flume with a fixed bottom, in course of preparation for sediment transport measurements. The obtained flow and friction parameters are evaluated and compared with both laboratory data in literature obtained for similar test flumes with rectangular section and analytic elaborations. The influence of storage, reflection and deformation in the circular flume is quantified
Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data

Diabetes mellitus (DM) and osteoarthritis (OA) are commonly known metabolic diseases that affect a large segment of the world population. These two conditions share several risk factors such as obesity and aging; however, there is still no consensus regarding the direct role of DM on OA development and progression. Interestingly, both animal and human studies have yielded conflicting results, with some showing a significant role for DM in promoting OA, while others found no significant interactions between these conditions. In this review, we will discuss preclinical and clinical data that assessed the interaction between DM and OA. We will also discuss possible mechanisms associated with the effect of high glucose on the articular cartilage and chondrocytes. An emerging theme dominates the breath of published work in this area: most of the studies discussed in this review do not take into consideration the role of other factors such as the type of diabetes, age, biological sex, type of animal model, body mass index, and the use of pain medications when analyzing and interpreting data. Therefore, future studies should be more rigorous when designing experiments looking at DM and its effects on OA and should carefully account for these confounding factors, so that better approaches can be developed for monitoring and treating patients at risk of OA and DM. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Study on Angular Free Vibration Stability and Parameters Influence of Dry Gas Seal Based on the Characteristic Equation

Based on Laplace transform and Hurwitz stability criterion, the system characteristic equation and algebraic stability criterion of the two degree-of-freedom angular free vibration of dry gas seal are derived. The effects of rotational inertia, stiffness and damping parameters on the angular free vibration stability of dry gas seal are analyzed by using the root locus method and the concept of the closed-loop dominant pole. The results show that the constraint condition of rotational inertia is the most demanding of all stability conditions. Both the angular main damping and main stiffness are not simply the larger the better, but there are preferred values in the interval greater than the stability threshold. The approach of the absolute value of the cross coefficient to zero is beneficial to the suppression of angular free vibration. There is a threshold of rotational inertia, which makes the cross stiffness change from having only the lower limit value to both the upper and lower critical values at the same time.
Load capacity of squat RC shear walls by strut-and-tie model

A simplified strut-and-tie model (STM) is established, based on the crack band theory of fracture mechanics for evaluating the lateral load capacity of squat reinforced concrete (RC) shear walls. The load transfer mechanism of concrete is identified by the strut-and-tie action contributed by the web concrete and longitudinal reinforcement of the boundary elements of the walls, whereas that of shear reinforcement is identified by the tie action idealised using a statically indeterminate truss system. The load transfer capacities of the concrete strut and shear reinforcement are driven using the energy equilibrium in the stress relief strip and the crack band zone formed along a diagonal crack. The width of the main concrete strut is determined using the neutral axis depth simplified as a function of the longitudinal reinforcement ratio and the elastic modulus ratio between concrete and reinforcing bars. Predictions made by the proposed model are in better agreement with test results compiled from 150 speci.
Nutritional, Functional, Textural and Sensory Evaluation of Spirulina Enriched Green Pasta: A Potential Dietary and Health Supplement

In house cultivated Spirulina powder was incorporated at 2 to 15% concentrations to enrich pasta prepared from semolina. Spirulina incorporation led to development of green color pasta with nutritional and functional fortification resulting in increase in its protein, total phenols, flavonoids, iron and calcium content by up to 77.47%, 76.62%, 162.88%, 296.99% and 57.27%, respectively, without causing detrimental changes to the textural and sensory attributes. FAME analysis revealed 2 to 2.5 times enhanced levels of γ-linolenic acid and docosahexaenoic acid in enriched pasta. Significant improvement in phenolics, flavonoids and antioxidant activity were also observed in comparison to control pasta. Analysis of theoretical and realized composition confirmed retention of nutrients post cooking revealing no significant loss in proteins and other nutrients. Principal components analysis demonstrated significant contribution of Spirulina to nutritional and functional attributes especially at higher concentrations. Pasta enriched with 12.5% Spirulina was rated as “liked very much” and the purchase intention was also high. Spirulina enrichment at concentrations above 10% (12.5%) with appreciable increase in nutritional and functional attributes without affecting textural or cooking quality and acceptable sensory evaluation can be a preferred alternative to augment health and prevent sickness. Since green color symbolizes freshness, hope, renewal and physical health, the consumption of Spirulina incorporated green pasta may be a potential option to enhance the livelihood and nutritional security of rural poor and a good alternative for hidden hunger alleviation programs for mass nutrition especially for infants and children in an effective manner.
Hydrodistillation and Microwave Extraction of Volatile Compounds: Comparing Data for Twenty-One Veronica Species from Different Habitats

Free volatile compounds were isolated from 21 Croatian Veronica species studied by hydrodistillation (HD) and microwave extraction (ME) and analyzed by gas chromatography coupled with mass spectrometry. Principal Component Analysis (PCA) distinguished some clusters based on the relative proportion of major compounds, such as hexadecanoic acid, hexahydrofarnesyl acetone, phytol, E-caryophyllene, and caryophyllene oxide, which were identified in all species studied by both isolation methods. In addition to these compounds, germacrene D, δ-selinene, and eicosane were also identified in five samples from dry habitats isolated using ME. Allo-aromadendrene and β-ionone are particularly abundant in five species from wet habitats isolated by both methods. The peculiarities of Veronica species from moderate habitats isolated with HD are benzene acetaldehyde, n-nonanal, and the identification of significant compounds from the hydrocarbon class, while the peculiarity of ME is (E)-β-damascenone. In this article, we present new results on the phytochemical characterization of Veronica species from different habitats. The biological potential of these compounds should be further investigated for a better understanding and utilization of the specialized plant metabolites.
Clinical and radiological characteristics of adult hospitalized coronavirus disease-2019 patients of Dhaka, Bangladesh

The severity of Coronavirus disease-2019 (COVID-19) varies among individuals and some influential factors leads to critical infections and death. This study aimed to assess various clinical data of hospitalized patients and identify the determinants of critical COVID-19 infection. This was a cross-sectional study among hospitalized COVID-19 patients confirmed by reverse transcription polymerase chain reaction (RT-PCR). Data was collected from a single Centre between January to April 2021 by experienced physicians of Ad-din Medical College Hospital. All of the laboratory tests were performed by technical experts and the data was analyzed by Statistical package for the social sciences software. Among the study participants 25% were Intensive care unit (ICU) patients and the mean age of them were higher (59 years) than non-ICU (55 years) patients. Our analysis has identified diabetes mellitus (AOR=2.5, 95%CI: 1.1-5.4) and ischemic heart disease (AOR=3.1, 95%CI: 1.1-8.9) as significant predictor of critical outcome (ICU admission). Anemia (AOR=3.3, 95%CI: 1.5-7.4), lymphopenia (AOR=2.9, 95%CI: 1.2-7.1), and thrombocytopenia (AOR=4.2, 95%CI: 2.7-12.9) was also associated critical outcome. Biomarkers of kidney injury (creatinine, blood urea nitrogen), liver damage (alanine transaminase, aspartate aminotransferase, fibrinogen) and electrolyte imbalance (sodium and potassium level) were also significantly associated with critical infection. A higher d-dimer level (≥2.5) was the most important predictor (AOR=11.5, 95%CI: 5.4-24.6) of critical COVID 19 infections. The study has revealed socio-demographic, comorbidity, and radiological risk factors of critical COVID-19 infections. The identified risk factors would be considered for decision making during the treatment process. Asian J. Med. Biol. Res. 2022, 8 (1), 16-23
Addition of Trehalose of Duck Egg Yolk-Tris as an Extender Medium on Buffalo Frozen Semen

This study aimed to determine the effect of adding trehalose of duck egg yolk-tris extender medium on the quality of frozen semen at buffalo. The design used was experimental a Randomized Block Design (RBD) method with 4 treatments and 4 replications as a group. The addition of trehalose (T) with several concentrations in the extender of tris duck-egg yolk as the first treatment, namely the control consisted of egg yolk tris 80% + 20% + 0% trehalose (T0), the second treatment 0.5% (T1), the third treatment % (T2) and the fourth treatment 1.5% (T3). The observed variables included: motility, viability, abnormality, and membrane integrity. The results of this study showed that the addition of trehalose of duck egg yolk-tris had a non-significantly different effect (P>0.05) on the percentage of spermatozoa motility with the average successively at T0, T1, T2 and T3, namely 25.00±5.80. %, 27.50±5.00%, 30.00±8.17%, 32.50±5.00%, the effect was very significant (P<0.01) on the percentage of spermatozoa viability and membrane integrity, with the mean successively at treatment T0 that is 42.25±2.60%, 43.25±2.90%, T1 44.00±2.68%, 46.00±2.40, T2 46 ,63±1.11%, 48.25±1.26%, T3 48.25±1.50%, 49.50±2.39%, significantly different effects (P<0.05) on spermatozoa abnormality with the mean successively at T0, T1, T2 and T3 that is 12.38±1.66%, 18.00±3.24%, 19.63±9.07%, 25.50±9.06% . The results of the study concluded that the addition of trehalose to the tris of duck egg yolks could maintain the motility, viability, membrane integrity of spermatozoa, but the addition of trehalose was unable to maintain the abnormality of Buffalo spermatozoa. on spermatozoa motility, spermatozoa survival percentage, spermatozoa abnormalities and intact plasma membranes of buffalo spermatozoa after thawing.
Positive Correlation of Oestradiol Level on Trigger Day with the Secretion Level of Endometrial Kisspeptin and Leukaemia Inhibitory Factor in the Mid-Luteal Stimulated Cycle

Background: Kisspeptin plays a role in the oestradiol negative-feedback regulation of GnRH as well as gonadotropin. In addition, kisspeptin has been postulated to induce the production of an important cytokine called leukaemia inhibitory factor (LIF). Aims: This study aims to investigate the correlation between varying oestradiol levels measured on trigger day of the ovarian stimulation and the mRNA expression level of endometrial kisspeptin and LIF. Study Setting and Design: Prospective cross-sectional study took place in Morula IVF Jakarta clinic. Materials and Methods: A total of 43 infertile couples underwent an in-vitro fertilization (IVF) program. Subjects were grouped based on oestradiol levels as follows: group A ([≧ 3000 pg/mL, n = 15], group B [2000–2999 pg/mL, n = 14], group C [<2000 pg/mL, n = 14]). Statistical Analysis Used: ANOVA test was utilised to compare the expression of kisspeptin and LIF among study groups while Pearson correlation was used to identify the correlation between variables. Results: A significantly higher mRNA expression of both Kisspeptin and LIF was found in group A than in groups B and C (P < 0.001). The mRNA expression of kisspeptin and LIF correlated positively with the oestradiol level (r = 0.638, P < 0.001 and r = 0.634, P < 0.001, respectively). Moreover, a strong association between Kisspeptin and LIF expression was also detected (r = 0.700, P < 0.001). Conclusions: mRNA expression of kisspeptin and LIF was significantly different according to the oestradiol levels in the study groups. Increased oestradiol level was shown to elevate the expression of endometrial kisspeptin and LIF in women undergoing the IVF programme.
The Influence of Paternalistic Leadership On Individual Performance

Introduction/Main Objectives: Paternalistic leadership as a unique leadership behavior has received the attention of researchers from various countries. The application of effective paternalistic leadership occurs in high power-distance and collectivistic cultures. Background Problems: Most studies examine the influence of paternalistic leadership at the dimensional level. In addition, the issue in paternalistic leadership research is directed to review the presence of paternalistic leadership on members’ attitudes. Novelty: First, this study is aimed at testing the united dimensions of paternalistic leadership. Second, this study focuses on the psychological mechanisms underlying the impact of paternalistic leadership on individual tasks and contextual performance. Third, this study adopts social exchange theory and affective events theory to review the role of paternalistic leadership. Research Methods: Using a statistical test of mediating process with the approach of the causal chain. This research was carried out in the context of organizations in various sectors. Finding/Results: Firstly, paternalistic leadership is present in varied organizations. Secondly, paternalistic leadership significantly influences individual tasks and contextual performance. Moreover, the findings reveal that trust in leadership enables to explain the relationship between paternalistic leadership and individual tasks and contextual performance.
The Efficacy Of Autologous Stem Cell Transplants To Treat High Risk Neuroblastoma

High Risk Neuroblastoma is a pediatric cancer that arises from immature nerve cells. While low and intermediate risk neuroblastomas remain curable with high survival rates, high risk neuroblastoma (HRNB) patients have less than a 50 percent chance of survival. Due to this disparity HRNB patients undergo intense multimodal treatment, while researchers attempt to find the best variants and combinations of treatments that will improve this statistic. One factor of interest in treatment is the autologous stem cell transplant (ASCT). ASCT have been found to improve event free survival (EFS) when compared to continuing chemotherapy, however overall survival (OS) rates remain unchanged. Similarly, tandem ASCT has improved EFS significantly compared to a single transplant, while OS remains the same. While OS is the standard for measuring the efficacy of oncological treatments, with a cancer as aggressive as HRNB improved EFS is satisfactory. Thus, single transplants should be continued, and tandem transplants should be implemented when indicated. characteristics, including MYCN , contemporary induction, and pre-minimal residual disease (MRD)-positivity. This suggest that there is a need for reevaluation of stem cell transplants in the treatment of HRNB. concludes that ASCT does not have a significant effect on improving EFS or OS when local RT, anti-GD2 and are used for consolidation after dose-intensive induction chemotherapy and suggests reevaluating the use of ASCT in treating HRNB
An efficient pre-coding TDD-Massive MIMO system for 5G networks

In future 5G wireless systems with wide-band MIMO and ultra-high-density cells, the reduced delay back and forth between mobile device and base station requires 1ms primary band processing delay. In a large-scale MIMO downlink(DL) system, An orthogonal pilot sequence is send to base station from user for channel estimation of uplink training. The advanced MIMO downlink TDD systems technology has been developed taking into account the effects of experimental pollution on channel estimation with consideration of Uplink(UL). The pre-coding system is widely applied with experimental reuse factors to mitigate the effects of experimental pollution. This achieves a higher transfer rate than traditional methods. The first PLS technology considered in this proposed method is a possible beam forming technique using MIMO. In addition to beam formation, the artificial noise (AN) technology is also validated. AN also reduces the transmitter's listening ability to detect and decode information signals addressed to the intended receiver by generating random noise signals in addition to information signals. This proposed work provides current channel estimation and MIMO detection algorithms for MIMO on a large scale to reduce the computational cost of broadband matrix computing. Channel reciprocity allows the base station only to obtain channel status information (CSI) from UL pilots. Two current algorithms have been introduced for each LS, MMSE, ZF and MMSE procedure based on a simplified uplink model, performance of this traditional approach has been measured in MSE and BER. MATLAB simulation is performed based on the proposed massive MIMO and the results are presented.
Selection Criteria for Air Tamponade During Vitrectomy for Rhegmatogenous Retinal Detachment

Purpose To compare air tamponade and sulfur hexafluoride (SF6) gas tamponade during vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD). Methods We reviewed 294 eyes with RRD treated with 25-gauge vitrectomy by a single surgeon between June 2011 and April 2018 retrospectively. The exclusion criteria for the proposed air tamponade selection were more than 2 weeks since onset, giant retinal tears, history of complications following cataract surgery, high myopia, and proliferative vitreoretinopathy classified as grade C or higher. We examined the differences in the therapeutic effect between the air group and SF6 group at 6-month follow-up. Results A total of 294 eyes were included in the study, 156 eyes in the air group and 138 eyes in the SF6 group. No difference was observed in the primary anatomical success rates between the air group (99.4%; 155/156 eyes) and the SF6 group (96.5%; 135/138 eyes; P = 0.102). Postoperative intraocular gas half-life was shorter in the air group (3.97 ± 0.87 days) compared with the that in the SF6 group (8.67 ± 1.47 days; P = 0.0001). The incidence of postoperative ocular hypertension was lower in the air group (19.9%; 31/156 eyes) than in the SF6 group (62.3% 86 /138 eyes; P = 0.0001). Conclusion We compared the criteria for proper selection between air and SF6 gas tamponade during vitrectomy for the treatment of RRD. Air tamponade was able to reduce the period of prone position and the risk of ocular hypertension without reducing the therapeutic effect.
High postoperative carcinoembryonic antigen as an indicator of high-risk stage II colon cancer

Postoperative carcinoembryonic antigen (post-CEA) has recently been reported to be a reliable prognostic factor for colon cancer. However, most clinicians decide whether or not to conduct adjuvant chemotherapy (AC) for stage II colon cancer according to major guidelines, which do not include post-CEA in their high-risk criteria. The present study aimed to assess post-CEA in stage II colon cancer for which the significance of AC is unknown. The present study analyzed 199 consecutive patients with stage II colon cancer who underwent curative surgery between January 2007 and December 2016. The CEA value was considered high when it was ≥5.0 ng/ml. The prognostic value of high post-CEA values was assessed. Overall, 19 patients exhibited high post-CEA levels. Kaplan-Meier survival curve analysis demonstrated that patients with high post-CEA levels had significantly worse relapse-free survival (RFS) and overall survival (OS) than those with normal post-CEA [RFS, 63.5 (high post-CEA) vs. 88.0% (normal post-CEA), P=0.003; OS, 76.5 (high post-CEA) vs. 96.8% (normal post-CEA), P<0.001]. Multivariate analysis demonstrated that high post-CEA remained a significant independent risk factor for worse RFS [hazard ratio (HR), 3.98; P=0.006]. The same was also demonstrated for patients without AC (HR, 5.43; P=0.008). To the best of our knowledge, the present study was the first to demonstrate that high post-CEA levels may be an indicator of high-risk stage II colon cancer, even for patients without AC. These results highlight the need for a multicenter prospective study.