Miracle-dz/UniFAR-FTUs huggingface dataset:
Unsupervised frequency domain information guided generative adversarial networks for pan-sharpening

Pan-sharpening of multispectra images aims to obtain an image that contains both high spectral and spatial resolution by fusing multispectral(MS) and panchromatic(PAN) images. In practice, unsupervised deep learning methods can be trained using raw full-resolution images and have particular advantages over supervised methods. However, since unsupervised methods cannot rely on labels to learn explicit mapping, it is hard to preserve and utilize the spectral and spatial knowledge in full-resolution images. To solve this problem, we pay special attention to frequency decoupling and utilization of input full-resolution images by unsupervised generative adversarial networks. The new generator network not only extracts spatial details in the high-frequency domain but also focuses on the interaction of sub-bands with sufficient low-frequency knowledge. At the same time, the new discriminator network also innovatively integrates the prior information of frequency enhancement. The qualitative and quantitative experimental results on Quickbird and Gaofen-2 datasets demonstrate that the challenging pan-sharpening task can be effectively performed by focusing on decoupled high and low-frequency information in both generator and discriminator networks.
Coenzyme Q10 and Fish Oil Supplementation for Reducing Retinal Oxidative Stress in a Rat Model

Extremely low gestational-age neonates requiring supplemental oxygen experience intermittent hypoxia (IH) episodes, which predispose them to oxidative stress and retinopathy of prematurity. We tested the hypothesis that early supplementation with fish oil or CoQ10 confers benefits reducing the severity of IH-induced retinopathy. At birth, rat pups were exposed to two clinically relevant neonatal IH paradigms with recovery in either hyperoxia (50% O2) or room air (RA) between episodes for 14 days, during which they received daily oral fish oil, coenzyme Q10 (CoQ10) in olive oil (OO), or OO only (vehicle). At postnatal day 14 (P14), pups were allowed to recover in RA with no further treatment until P21. Retinas were examined at P14 and at P21. Both IH paradigms resulted in severe ocular oxidative stress and retinopathy regardless of recovery in hyperoxia or RA in the vehicle groups. Although early supplementation with fish oil was beneficial, CoQ10 provided superior benefits for reducing IH-induced oxidative stress and retinopathy. These effects were associated with lower retinal antioxidants and biomarkers of angiogenesis. The therapeutic benefits of CoQ10 suggest a potential treatment for IH-induced retinopathies. Further studies are needed to establish appropriate, safe, and effective doses for use in preterm infants.
Sleep Disturbance and Immunological Consequences of COVID-19

Abstract The overarching importance of sleep was further emphasized during the pandemic of COVID-19. The subjects infected by COVID-19 frequently experience sleep disturbances; some are long-lasting problems and decrease the quality of life. Insomnia is the most studied sleep disorder associated with COVID-19. Insomnia affects patients who have experienced an infection and the general population. Good sleep is important in maintaining mental and physical health, including immune system functions. The interconnections between insomnia, the immune system, and COVID-19 are complex. Insomnia triggers numerous immune system dysregulations and makes individuals more vulnerable to respiratory infections. This narrative review overviews the influence of the COVID-19 pandemic on the immune system through sleep disorders.
Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione peroxidase 4 (GPX4), a key intracellular antioxidant regulator, promotes ferroptosis in different cell types. Scant information is available on GPX4-induced ferroptosis in hippocampal neurons. Moreover, the role of calcium (Ca2+) signaling in ferroptosis remains elusive. Here, we report that RSL3, a selective inhibitor of GPX4, caused dendritic damage, lipid peroxidation, and induced cell death in rat primary hippocampal neurons. Previous incubation with the ferroptosis inhibitors deferoxamine or ferrostatin-1 reduced these effects. Likewise, preincubation with micromolar concentrations of ryanodine, which prevent Ca2+ release mediated by Ryanodine Receptor (RyR) channels, partially protected against RSL3-induced cell death. Incubation with RSL3 for 24 h suppressed the cytoplasmic Ca2+ concentration increase induced by the RyR agonist caffeine or by the SERCA inhibitor thapsigargin and reduced hippocampal RyR2 protein content. The present results add to the current understanding of ferroptosis-induced neuronal cell death in the hippocampus and provide new information both on the role of RyR-mediated Ca2+ signals on this process and on the effects of GPX4 inhibition on endoplasmic reticulum calcium content.
Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells

Akt is a key regulatory protein of cancer stem cells (CSCs) and is responsible for cancer aggressiveness and metastasis. Targeting Akt is beneficial for the development of cancer drugs. renieramycin T (RT) has been reported to have Mcl-1 targeting activity, and the study of the structure-activity relationships (SARs) demonstrated that cyanide and the benzene ring are essential for its effects. In this study, novel derivatives of the RT right-half analog with cyanide and the modified ring were synthesized to further investigate the SARs for improving the anticancer effects of RT analogs and evaluate CSC-suppressing activity through Akt inhibition. Among the five derivatives, a compound with a substituted thiazole structure (DH_25) exerts the most potent anticancer activity in lung cancer cells. It has the ability to induce apoptosis, which is accompanied by an increase in PARP cleavage, a decrease in Bcl-2, and a diminishment of Mcl-1, suggesting that residual Mcl-1 inhibitory effects exist even after modifying the benzene ring to thiazole. Furthermore, DH_25 is found to induce CSC death, as well as a decrease in CSC marker CD133, CSC transcription factor Nanog, and CSC-related oncoprotein c-Myc. Notably, an upstream member of these proteins, Akt and p-Akt, are also downregulated, indicating that Akt can be a potential target of action. Computational molecular docking showing a high-affinity interaction between DH_25 and an Akt at the allosteric binding site supports that DH_25 can bind and inhibit Akt. This study has revealed a novel SAR and CSC inhibitory effect of DH_25 via Akt inhibition, which may encourage further development of RT compounds for cancer therapy.
PPAR Alpha Activation by Clofibrate Alleviates Ischemia/Reperfusion Injury in Metabolic Syndrome Rats by Decreasing Cardiac Inflammation and Remodeling and by Regulating the Atrial Natriuretic Peptide Compensatory Response

Metabolic syndrome (MetS) is a cluster of factors that increase the risk of developing diabetes, stroke, and heart failure. The pathophysiology of injury by ischemia/reperfusion (I/R) is highly complex and the inflammatory condition plays an important role by increasing matrix remodeling and cardiac apoptosis. Natriuretic peptides (NPs) are cardiac hormones with numerous beneficial effects mainly mediated by a cell surface receptor named atrial natriuretic peptide receptor (ANPr). Although NPs are powerful clinical markers of cardiac failure, their role in I/R is still controversial. Peroxisome proliferator-activated receptor α agonists exert cardiovascular therapeutic actions; however, their effect on the NPs’ signaling pathway has not been extensively studied. Our study provides important insight into the regulation of both ANP and ANPr in the hearts of MetS rats and their association with the inflammatory conditions caused by damage from I/R. Moreover, we show that pre-treatment with clofibrate was able to decrease the inflammatory response that, in turn, decreases myocardial fibrosis, the expression of metalloprotease 2 and apoptosis. Treatment with clofibrate is also associated with a decrease in ANP and ANPr expression.
Evolution of radiating solitons in plasmas

Because of the plasma embedded in a static magnetic field, the dispersiveness in the Korteweg-deVries (K-dV) equation varies, thereby changing the inherent structure of the plasma-acoustic wave. It is quite difficult to solve the nonlinear wave equation derived in. such circumstances, and thus to study the soliton dynamics in plasma-acoustic mode. A recent formalism, known as sine-Gordon method, has been developed to solve the modified K-dV equation derived with higher order dispersive effect. The method has its success in finding the solitary wave solution along with an exciting observation on the formation of narrow soliton wave-packet, wherein a continuous intensification of electric field pressure occurs. In addition, the solution explains the phenomena of radiation associated with soliton propagation.
An Overview towards Zebrafish Larvae as a Model for Ocular Diseases

Despite the obvious morphological differences in the visual system, zebrafish share a similar architecture and components of the same embryonic origin as humans. The zebrafish retina has the same layered structure and cell types with similar metabolic and phototransduction support as humans, and is functional 72 h after fertilization, allowing tests of visual function to be performed. The zebrafish genomic database supports genetic mapping studies as well as gene editing, both of which are useful in the ophthalmological field. It is possible to model ocular disorders in zebrafish, as well as inherited retinal diseases or congenital or acquired malformations. Several approaches allow the evaluation of local pathological processes derived from systemic disorders, such as chemical exposure to produce retinal hypoxia or glucose exposure to produce hyperglycemia, mimicking retinopathy of prematurity or diabetic retinopathy, respectively. The pathogenesis of ocular infections, autoimmune diseases, or aging can also be assessed in zebrafish larvae, and the preserved cellular and molecular immune mechanisms can be assessed. Finally, the zebrafish model for the study of the pathologies of the visual system complements certain deficiencies in experimental models of mammals since the regeneration of the zebrafish retina is a valuable tool for the study of degenerative processes and the discovery of new drugs and therapies.
Water Quality, Toxicity and Diversity of Planktonic and Benthic Cyanobacteria in Pristine Ancient Lake Khubsugul (Hövsgöl), Mongolia

For the first time, microcystin-producing cyanobacteria have been detected in Khubsugul, which is ancient, pristine and one of the world’s largest lakes. The microcystin synthetase genes belonged to the genera Nostoc, Microcystis and possibly Snowella spp. No microcystins were found in the water of the lake. Using the HPLC-HRMS/TOF, five microcystin congeners were identified in biofilms from stony substrates sampled in the coastal zone. The concentration of microcystins in biofilms was low: 41.95 µg g−1 d. wt. by ELISA and 55.8 µg g−1 d. wt. using HPLC. The taxonomic composition of planktonic and benthic cyanobacterial communities was determined by means of microscopy and high-throughput sequencing of 16S rDNA amplicons. Nostocales cyanobacteria dominated benthos of Lake Khubsugul and Synechococcales—plankton. The abundance of cyanobacteria was low both in plankton and benthos; there was no mass development of cyanobacteria. Hydrochemical and microbiological analyses showed that the water in the lake was clean; the number of faecal microorganisms was significantly below the acceptable guideline values. Hydrochemical and hydrophysical parameters, and the concentration of chlorophyll a, were low and within the range of values recorded in the 1970s to 1990s, and corresponded to the oligotrophic state of the lake. There were no signs of anthropogenic eutrophication of the lake and no conditions for the cyanobacterial blooms.
An Analysis of Deep Learning Models in SSVEP-Based BCI: A Survey

The brain–computer interface (BCI), which provides a new way for humans to directly communicate with robots without the involvement of the peripheral nervous system, has recently attracted much attention. Among all the BCI paradigms, BCIs based on steady-state visual evoked potentials (SSVEPs) have the highest information transfer rate (ITR) and the shortest training time. Meanwhile, deep learning has provided an effective and feasible solution for solving complex classification problems in many fields, and many researchers have started to apply deep learning to classify SSVEP signals. However, the designs of deep learning models vary drastically. There are many hyper-parameters that influence the performance of the model in an unpredictable way. This study surveyed 31 deep learning models (2011–2023) that were used to classify SSVEP signals and analyzed their design aspects including model input, model structure, performance measure, etc. Most of the studies that were surveyed in this paper were published in 2021 and 2022. This survey is an up-to-date design guide for researchers who are interested in using deep learning models to classify SSVEP signals.
Metformin Attenuates the Inflammatory Response via the Regulation of Synovial M1 Macrophage in Osteoarthritis

Osteoarthritis (OA), the most common chronic inflammatory joint disease, is characterized by progressive cartilage degeneration, subchondral bone sclerosis, synovitis, and osteophyte formation. Metformin, a hypoglycemic agent used in the treatment of type 2 diabetes, has been evidenced to have anti-inflammatory properties to treat OA. It hampers the M1 polarization of synovial sublining macrophages, which promotes synovitis and exacerbates OA, thus lessening cartilage loss. In this study, metformin prevented the pro-inflammatory cytokines secreted by M1 macrophages, suppressed the inflammatory response of chondrocytes cultured with conditional medium (CM) from M1 macrophages, and mitigated the migration of M1 macrophages induced by interleukin-1ß (IL-1ß)-treated chondrocytes in vitro. In the meantime, metformin reduced the invasion of M1 macrophages in synovial regions brought about by the destabilization of medial meniscus (DMM) surgery in mice, and alleviated cartilage degeneration. Mechanistically, metformin regulated PI3K/AKT and downstream pathways in M1 macrophages. Overall, we demonstrated the therapeutic potential of metformin targeting synovial M1 macrophages in OA.
The theory of nonlinear ion-acoustic waves revisited

The basic set of equations describing nonlinear ion-acoustic waves in a cold collisionless plasma, in the limit of long wavelengths, is reconsidered. First, a travelling-wave solution is found up to third order by means of a straightforward perturbation approach based on the smallness of the wavenumber. As a result, a positive dressed solitary wave shows up, which is larger, taller and faster than the KdV soliton, the first-order result. Furthermore, the accuracy of this approach is tested and compared with previous result. Secondly, the reductive perturbation techique to study higher-order corrections is revised and adapted to the present problem.
Martian planetary heavy ion sputtering of Phobos

The Martian moons, Phobos and Deimos, have long been suspected to be the sources of tenuous neutral gas tori encircling Mars. While direct outgassing has been ruled out as a strong source, micrometeoroid impact vaporization and charged particle sputtering must operate based on observations at other airless bodies. Previous models have addressed solar wind sputtering of Phobos; however, Phobos and Deimos are also subject to a significant, yet temporally variable, flux of heavy planetary ions escaping from Mars. In this report, we use a combination MHD/test‐particle model to calculate the planetary heavy ion flux to Phobos and the ensuing neutral sputtered flux. Depending on ambient solar wind conditions and the location of Phobos, heavy ion sputtering of Phobos generates neutral fluxes up to and exceeding that from solar wind sputtering. We model pickup ions from the Phobos torus itself with applications for observations by the upcoming Mars Atmospheric and Volatile Evolution mission.
Effects of milk, milk replacer, and milk replacer plus ethoxyquin on the growth performance, weaning stress, and the fecal microbiota of Holstein dairy calves

The growth and health statuses of calves during the early stages of development have a significant effect on milk production during their first lactation period. Using appropriate milk replacers helps meet the long-term targets of dairy farmers. This study aimed to examine the effects of milk, milk replacer, and milk replacer plus ethoxyquin on growth performance, antioxidant status, immune function, and the gut microbiota of Holstein dairy calves. A total of 36 neonatal dairy calves were randomly divided into three groups and fed different diets: one group was fed milk, another group was fed milk replacer, and the third group was given milk replacer plus ethoxyquin. The supplementation with ethoxyquin was started on day 35 of the feeding period. The calves were weaned on day 45, and the experiment was conducted until day 49. The blood and fecal samples were collected at the end of the animal experiment. The results showed that milk replacers induced poor growth performance (body weight and average daily gain). However, milk replacer plus ethoxyquin aided in growth performance, enhanced the starter intake and blood antioxidative ability, and elevated the concentration of fecal valeric acid. Moreover, fecal fermentation and 16S rRNA analyses showed that milk replacer plus ethoxyquin altered the microbial composition (reducing Alistipes and Ruminococcaceae and increasing Bacteroides and Alloprevotella). Pearson's correlation assays showed that alterations in fecal microbiota strongly correlated with average daily gain and antioxidative ability. The results indicated the potential of milk replacer plus ethoxyquin in modulating the growth of dairy calves and in enhancing their ability to combat stress.
A Comprehensive Review of Anomaly Detection in Web Logs

Anomaly detection is a significant problem that has been researched within diverse research areas and application domains, especially in the area of web-based internet services or cybersecurity. Many anomaly detection techniques have been developed for specific application domains, while others are more generic. The Log files of Web-server give insight into the state of web-server and applications running on it and enable the detection of abnormal incidents or behavior. This paper focuses on particularly web-server HTTP logs to the problems of Web-server Log Anomaly Detection (WLAD) due to their own nature and features and aims to provide a brief review of different Data-driven techniques to get to the bottom of recent studies and developments made in the context of WLAD. Moreover, in this paper, the literature related to webserver logs analysis, as well as other closely related to the WLAD topic, are taken into consideration for review. We have classified existing techniques into different categories based on the underlying approach adopted. When applying a particular technique, these assumptions can be used as guidelines to assess the method’s effectiveness in this area. We also provide a basic security anomaly detection approach for each category and compare the existing methods as variants of the basic technique. Further, we identify the cons and pros of the current practices for each category. We also discuss the computational complexity of the methods, which is an essential issue in the domain of Big Data.
Hepatitis Risk in Diabetes Compared to Non-Diabetes and Relevant Factors: A Cross-Sectional Study with National Health and Nutrition Examination Survey (NHANES), 2013–2018

This study aimed to identify the development of hepatitis B or C infection in diabetes patients compared to those without and to elucidate factors associated with the prevalence of hepatitis B or C infection in diabetes. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2018. As evaluation factors, we included variables such as age, race, illicit drug use, and poverty. The diabetic group had a significantly higher prevalence of hepatitis B or C infection than the non-diabetic group (odds ratio (OR) = 1.73; 95% confidence interval (CI), 1.36–2.21, p < 0.01). In multivariate Cox regression, non-poverty and non-illicit drug use were lower risk factors contributing to hepatitis development in diabetes (hazard ratio (HR) = 0.50; 95% CI, 0.32–0.79, p < 0.01, and HR = 0.05; 95% CI, 0.03–0.08, p < 0.01, respectively). Logistic regression also showed that these factors were significant contributors to hepatitis development in the diabetic group (p < 0.01). In patients with diabetes, the development of hepatitis was higher than that in those without, and hepatitis development was influenced by poverty and illicit drug use. This may provide supporting evidence of response strategies for diabetes to care for hepatitis development in advance.
The Relationship of Board Attributes, Corporate Social Responsibility and Corporate Financial Performance in Chinese Technology-Listed Companies

—Chinese companies have paid more attention to corporate social responsibility (CSR) activities in recent years. This paper aimed to provide empirical evidence on the relationship between board attributes and CSR and between CSR and corporate financial performance of Chinese technology-listed companies. The data from 2011 to 2020 was obtained from the database systems of CSMAR, Bloomberg and Wind. A total of 2,726 listed technology companies in China were gathered. The data were analyzed by CSR metrics in the form of ESG scores using OLS regression analysis and fixed effect regression models. The findings report that Board independence is a strong driving force of CSR performance, whereas board gender has a significant negative impact on CSR performance. The correlation between board attendance and CSR performance is insignificant. CEO duality has a negative impact on CSR performance. The results highlight the importance of CSR performance which can promote corporate financial performance. This study fills up the gap in CSR related research in the technology industry and offer more evidence for further research between board diligence and CSR. The study presents feasible suggestions for enterprises in the Chinese technology industry to improve operation and management by providing theoretical and practical implications, to guide regulators and Chinese technology-listed companies in ensuring the sustainable development of the sector.