Miracle-dz/UniFAR-FTUs huggingface dataset:
Syddansk Universitet Polybrominated diphenyl ethers and tradtional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe Islands Fängström,

The observed high-level burdens of organohalogens among the residents of the Faroe Islands, needs to be explained. Long-finned pilot whale (Globicephala melas) blubber and meat are known sources of environmental exposure. The present study focus on the organohalogen contamination of the fulmar (Fulmarus glacialis). The compounds quantified in fulmar muscle, fat, and egg are PCBs, DDTs, hexachlorobenzene (HCB), and polybrominated diphenyl ethers (PBDEs). The dominating pollutants are the 4,4’-DDT metabolite 4,4’-DDE and the two PCB congeners, CB-153 and CB-180, which are present in geometric mean concentrations of 7100, 4700 and 2500 ng/g lipid weight (l.w.), respectively, in adult fulmar muscle. 4,4’-DDT and HCB concentrations are approximately 250 ng/g l.w. , each. Concentrations in the eggs are about 50% of the fulmar muscle levels, due to differences in lipid amounts, 4% in muscle and 10% in the eggs, the exposure contribution on a fresh weight basis is almost the same. As a result, both the egg and the adult fulmar muscle may lead to a significant exposure risk, if consumed by humans. BDE-153, the most abundant PBDE congener in fulmar muscle, with a geometric mean concentration of 6.5 ng/g l.w. , is much lower than the individual PCB congeners and 4,4’-DDE concentrations. In the adult fulmar muscle, the relative PBDE congener pattern is different from that previously observed in biota, with BDE-153 and BDE-154 as the dominating congeners, rather than BDE-47. In contrast, BDE-47 is the most abundant congener in juvenile muscle and subcutaneous fat. The ΣPBDE concentrations are almost the same in egg, muscle (adult and juvenile) and subcutaneous fat (juvenile). For the polybrominated biphenyl (BB-153) the concentrations are considerably higher in the adult bird and egg than in the juvenile bird; this is also seen for the PCB and 4,4’-DDE concentrations. PCB concentrations found in fulmar egg and muscle are in the same range as seen in the pilot whale, i.e. 590-5700 ng/g l.w. for CB-153. Hence humans are also exposed to PCBs at a reasonable degree via intake of fulmar and/or fulmar egg and not only via pilot whale blubber.
AENDO May 39/5

Youngren, Jack F. , Ira D. Goldfine, and Richard E. Pratley. Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E990–E994, 1999. —In a previous study [Youngren, J. F. , I. D. Goldfire, and R. E. Pratley. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E276– E283, 1997] of skeletal muscle biopsies from insulinresistant, nondiabetic Pima Indians, we demonstrated that diminished insulin receptor (IR) autophosphorylation correlated with in vivo insulin resistance. In the present study, to determine whether decreased IR function is a primary trait of muscle, and not secondary to an altered in vivo environment, we cultured myoblasts from 17 nondiabetic Pima Indians in whom insulin-stimulated glucose disposal (M) was measured during hyperinsulinemic-euglycemic glucose clamps. Myoblast IR autophosphorylation was determined by a highly sensitive ELISA. IR autophosphorylation directly correlated with M (r 5 0.56, P 5 0.02) and inversely correlated with the fasting plasma insulin (r 5 20.58, P , 0.05). The relationship between M and IR autophosphorylation remained significant after M was adjusted for the effects of percent body fat (partial r 5 0.53, P , 0.04). The relationship between insulin resistance and the capacity for myoblast IR autophosphorylation in nondiabetic Pima Indians suggests that variations in IR-signaling capacity may be intrinsic characteristics of muscle that contribute to the genetic component determining insulin action in this population.
ArticleThe Role of Location of Tumor in the Prognosis of the Pancreatic CancerMirang Lee †

Identification of prognostic factors is important to improve treatment outcomes in pancreatic cancer. This study aimed to investigate the effect of the location of pancreatic cancer on survival and to determine whether it was a significant prognostic factor. Altogether, 2483 patients diagnosed with pancreatic cancer were examined. Comparative analysis of clinicopathologic characteristics, survival analysis, and multivariate analysis were performed. Cancers of the pancreatic head or the uncinate process were present in 49.5% of patients. The head/uncinate cancers had more clinical T1/T2 tumors (59.4% vs. 35.5%, p < 0.001) and a significantly higher 5-year survival rate (8.9% vs. 7.3%, p < 0.001) than the body/tail cancers. The 5-year survival rate in patients with head/uncinate cancers was significantly lower in the resectable (p = 0.014) and the locally advanced groups (p = 0.007). In patients who underwent resection with curative intent, the 5-year survival rate was lower in the head/uncinate group (p = 0.046). The overall outcome of the head/uncinate cancers was better than the body/tail cancers, due to the high proportion of resectable cases. In patients who underwent curative resection, the head/uncinate cancers had a higher number of T1/T2 tumors, but worse outcomes. In the multivariate analysis, tumor location was not an independent prognostic factor for pancreatic cancer.
Deepbite Malocclusion: Analysis of Underlying Components in Different Facial Growth Patterns

Background: Deep bite malocclusion should not be approached as a disease entity; instead, it should be viewed as clinical manifestation of underlying discrepancies. The present study aim to evaluate parameters of deepbite in various growth patterns. Materials and Methods: Sample of 90 patients divided into groups of varying growth patterns: Vertical (FMA≥27°), Horizontal (FMA≤22°), Normal (FMA 22°-27°), were studied for cephalometric and dental measurements. Results: Curve of spee was major contributor to deep bite in all growth patterns. Gonialangle, and maxilla mandibular alveolar base heights were correlated with deep bite in horizontal growers. Inclination of maxillary and mandibular incisors was responsible for deep bite in vertical growth pattern. Conclusion: This analysis of deep bite components could help clinicians design individualized mechanotherapies based on underlying cause, rather than being biased toward predetermined mechanics when treating deep bite malocclusion. Hence, orthodontists should look for not just leveling of curve of spee but also the growth pattern of patient.
Facial Emotion Recognition Abilities in Women Suffering from Eating Disorders

OBJECTIVE Impairments in facial emotion recognition are an underlying factor of deficits in emotion regulation and interpersonal difficulties in mental disorders, and are evident in eating disorders (EDs). METHODS We used a computerized psychophysical paradigm to manipulate parametrically the quantity of signal in facial expressions of emotion (QUEST threshold seeking algorithm). This was used to measure emotion recognition in 311 adult women (anorexia nervosa (AN,n=61), bulimia nervosa (BN,n=58), healthy controls (HC,n=130) and mixed mental disorders (mixed,n=59)). The mean age was 22.84 years (SD=3.90). The aim was to establish recognition thresholds defining how much information a person needs to recognize a facial emotion expression and to identify deficits in EDs compared to healthy and clinical controls. The stimuli included six basic emotion expressions (fear, anger, disgust, happiness, sadness, surprise) plus a neutral expression. RESULTS Happiness was discriminated at the lowest, fear at the highest threshold by all groups. There were no differences regarding thresholds between groups, except for the mixed and the BN group with respect to the expression of disgust (F(3,302)=5.97, p=. 001, eta=. 056). Emotional clarity, ED pathology and depressive symptoms did not predict performance (RChange.010, F(1,305)5.74, p.079). The confusion matrix did not reveal specific biases in either group. CONCLUSIONS Overall, within-subject effects were as expected, whereas between-subject effects were marginal and psychopathology did not influence emotion recognition. Facial emotion recognition abilities in women suffering from EDs compared to women suffering from mixed mental disorders and HCs were similar. While basic facial emotion recognition processes seems to be intact, dysfunctional aspects such as misinterpretation might be important in emotion regulation problems. CLINICAL TRIAL REGISTRATION NUMBER DRKS-ID: DRKS00005709. DOI: https://doi.org/10.1097/PSY.0000000000000664 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-185532 Journal Article Published Version Originally published at: Wyssen, Andrea; Junpeng, Lao; Rodger, Helen; Humbel, Nadine; Lennertz, Julia; Schuck, Kathrin; Isenschmid, Bettina; Milos, Gabriella; Trier, Stephan; Whinyates, Katherina; Assion, Hans-Jörg; Ueberberg, Bianca; Müller, Judith; Klauke, Benedikt; Teismann, Tobias; Margraf, Jürgen; Juckel, Georg; Kossmann, Christian; Schneider, Silvia; Caldara, Roberto; Munsch, Simone (2019). Facial Emotion Recognition Abilities in Women Suffering from Eating Disorders. Psychosomatic Medicine, 81(2):155-164. DOI: https://doi.org/10.1097/PSY.0000000000000664
PROLIFERATIVE ACTIVITY OF T H E LYMPHATIC TISSUES OF RATS AS STUDIED WITH TRITIUM-LABELED THYMIDINE* BY CHARLES G. CRADDOCK,

Isotopic labeling of the DNA of blood cells has provided an important technique for obtaining information about the cytokinetics of white cells. It has been assumed that the DNA label is stable within a given lineage of cells. However, several papers have indicated reincorporation of tritiated thymidine (H3Tdr)-labeled deoxyribonucleic acid (H3DNA) of cells during catabolism by other proliferating cells. The tritiated thymidine is originally incorporated during DNA synthesis (I-6). Most interpretations of this finding have assumed that it is not the result of radiobiological artifact due to the isotope. Aside from the significance of this finding in terms of interpretation of data pertaining to cell renewal, life span, and possible transformation of blood cells into different morphological entities (7), the possibility of the DNA within cells being unstable has many other implications. The biochemistry of the transfer of DNA label remains to be elucidated. Hamilton (8), whose work in leukemic subjects led him to propose that DNA reutilization might occur within lymphatic tissue, believed that his data favored the reincorporation of fragments of DNA polymer rather than mononucleotides or nucleosides resulting from DNA breakdown. He pointed out that the earlier works of Ottesen (9) and Osgood et al. (10) were also consistent with this view. On the other hand, Robinson and Brecher have recently reported strong evidence suggesting that reincorporation of the DNA label in blood cells by rapidly growing liver cells occurs after breakdown of DNA to a nucleoside level (11). After flash labeling of the DNA of a portion of a normally replicating cell population which is in DNA synthesis at the time the H3Tdr is available, dilu-
Transendothelial Migration Endothelial Cells To Stimulate Dependent Mechanotransduction in - Factor, LARG, Mediates ICAM-1 The RhoA Guanine Nucleotide Exchange

RhoA-mediated cytoskeletal rearrangements in endothelial cells (ECs) play an active role in leukocyte transendothelial cell migration (TEM), a normal physiological process in which leukocytes cross the endothelium to enter the underlying tissue. Although much has been learned about RhoA signaling pathways downstream from ICAM-1 in ECs, little is known about the consequences of the tractional forces that leukocytes generate on ECs as they migrate over the surface before TEM. We have found that after applying mechanical forces to ICAM-1 clusters, there is an increase in cellular stiffening and enhanced RhoA signaling compared with ICAM-1 clustering alone. We have identiﬁed that leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF 12 (ARHGEF12) acts downstream of clustered ICAM-1 to increase RhoA activity, and that this pathway is further enhanced by mechanical force on ICAM-1. Depletion of LARG decreases leukocyte crawling and inhibits TEM. To our knowledge, this is the ﬁrst report of endothelial LARG regulating leukocyte behavior and EC stiffening in response to tractional forces generated by leukocytes. The Journal of Immunology , 2014, 192: 000–000. controlled in both the leukocyte and the endothelial cell (EC). early responders to of them to exit post-capillary venules and inﬁltrate tissues to ingest microbes or bodies,
Intracellular Pathogen NOS2 Activity and Unable to Control an Renders the Animal Functionally Deficient in Promoter Activity in the Syrian Hamster Reduced Nitric Oxide Synthase 2 (NOS2)

Progressive disease in the hamster model of visceral leishmaniasis, caused by Leishmania donovani , in contrast to infection in mice, mimics the progressive disease observed in untreated humans. During progressive infection in hamsters, there was a vigorous type 1 cellular immune response, which is typically associated with control of infection, suggesting that there was ineffective IFN- (cid:1) mediated macrophage activation. Indeed, at the site of infection, hamsters did not express NO synthase 2 (NOS2), which is the primary mechanism for control of infection in mice. Furthermore, in striking contrast to mouse macrophages, IFN- (cid:1) -activated hamster macrophages did not did not express NOS2 nor generate NO, and were unable to restrict the replication of intracellular L. donovani . The absent hamster NOS2 expression was not the result of NOS2 gene deletion and the NOS2 cDNA had an intact open reading frame. Furthermore, the impaired transcription of NOS2 mRNA was selective and not due to global impairment of IFN- (cid:1) signaling (members of the IFN- (cid:1) -signaling pathway were expressed and functional and IFN- (cid:1) up-regulated several primary and secondary response genes). Strikingly, the proximal hamster NOS2 promoter, like the human ortholog, had > 20-fold less basal and IFN- (cid:1) /LPS-inducible activity than the corresponding mouse promoter. Thus, reduced basal and IFN- (cid:1) -induced activity of the hamster NOS2 transcriptional unit, which is unique to this small animal and similar to the human counterpart, accompanies the inability of the animal to control an intracellular pathogen. The Journal of Immunology, 2006, 176: 5519–5528.
Retention factors of Malay male Architects in Malaysian architectural design consultant firms in the Klang Valley, Malaysia

The Malaysian construction industry suffers from a high rate of talent attrition within architecture design consultant firms which hinders these firms from competing locally and globally. This paper reports the research findings of a research into the factors that contribute to employee retention of a purposive sample of ten male professional Malay Architects in Malaysian architecture consulting firms in the Klang Valley. It explored the reasons for respondents remaining with their employers through data collected from qualitative interviews. The data in the form of interview transcripts, interview memos and analysis memos were analysed using category coding to generate meaning units and categories of employment retention. The analysis was based upon Alderfer’s ERG motivation theory. It was found that existence needs (convenience, physiological needs, material security), relatedness needs (group belongingness, social needs, family obligation, friendship obligation, employment group obligation, social obligation, and social esteem), growth needs (self-esteem and self-actualization) and intrinsic motives (choices, progress, competence and meaningfulness) underlie the employment retention of the respondents. The research findings provide insights about Malay male Architects employment retention factors in Malaysian architecture consulting firms.
Parents Attitude toward Education among Muslim

Education is one of the major instruments of social change and it is the force, which brings changes in the traditional outlook of the people, and it develops insight for judging things in their context. It is assume that more the percentage of educated people more will be the rate of development. As all we say that Education of a girl is like educating a family while educating a boy is merely educating a person. The importance of female education in a society and its spreading to all section of the life is well appreciated and documented to solve existing and emerging problems of the society. There is ample evidence that children from better educated parents more often go to school and tend to drop out less (UNESCO, 2010). Parents who have reached a certain educational level might want their children to achieve at least that level (Breen & Goldthorpe, 1997). For educational enrolment of girls, education of the mother might be especially important (Emerson & Portela Souza, 2007; Shu, 2004; Kambhampati & Pal, 2001; Fuller, Singer and Keiley, 1995). Mothers who have succeeded in completing a certain level of education have experienced its value and know that it is within the reach of girls to complete that level. The present research was aimed at assessing attitude of parents toward education among Muslim. Sample consists of 100; in which 50 male respondents and 50 female respondents were participated in the present research. Parents’ attitude was measured through Questionnaire consisting 23 items which is developed by Patnaik & Samal (2012). The respondents were required to indicate their agreement or disagreement with each of the statements about children’s education in a four-point Likert type scale, where 1 denotes strong disagreement and 4 denotes strong agreement. Mean scores were calculated separately for male and female respondents and high socio economic status and low socio economic status samples. The t test was used to examine the significance of difference between male and female respondents as well as high socio economic status and low socio economic status with regard to their attitude towards children’s education. The findings showed that the overall attitude of the respondents was moderately favourable and positive towards education of their children. This result was discussed in the light of existing findings and with other demographic variable i.e. education of the parents, income of the parents and number of children.
Differentially Expressed During Spermatogenesis

Using several actin isotype-specific cDNA probes, we found actin mRNA of two size classes, 2.1 and 1.5 kilobases (kb), in extracts of polyadenylated and nonpolyadenylated RNA from sexually mature CD-1 mouse testes. Although the 2.1-kb sequence was present in both meiotic and postmeiotic testicular cell types, it decreased manyfold in late haploid cells. The 1.5-kb actin sequence was not detectable in meiotic pachytene spermatocytes (or in liver or kidney cells), but was present in round and elongating spermatids and residual bodies. To differentiate between the I8and y-actin mRNAs, we isolated a cDNA, pMGA, containing the 3' untranslated region of a mouse cytoplasmic actin that has homology to the 3' untranslated region of a human -y-actin cDNA but not to the 3' untranslated regions of human a-, i-, or cardiac actins. Dot blot hybridizations with pMGA detected high levels of presumptive -y-actin mRNA in pachytene spermatocytes and round spermatids, with lower amounts found in elongating spermatids. Hybridization with the 3' untranslated region of a rat 0-actin probe revealed that round spermatids contained higher levels of 3-actin mRNA than did pachytene spermatocytes or residual bodies. Both probes hybridized to the 2.1-kb actin mRNA but failed to hybridize to the 1.5-kb mRNA.
DiscardLess Strategies for the gradual elimination of discards in European fisheries

This report identifies good practice for implementing a discard ban based on four lines of work. First, a comparative examination was conducted of selected cases worldwide where discard bans have been implemented. This work focused on the cases of Norway, Chile, New Zealand and the EU. Second, bycatch management practices were examined more broadly and globally. Third, experiences with first year of the EU’s Landing Obligation (LO) were examined for the Baltic and Pelagic fisheries. These cases potentially offer valuable lessons for discard management in the context of the LO with regard to cooperation with stakeholders, cooperation between member states and the design and implementation of discard mitigation strategies. Fourth, innovative management approaches to reduce discarding are ebing identified and evaluated. Drawing on results from task 4.4: “The manager’s story”, these include approaches to enhance quota flexibility and direct management measures such as Real Time Closures. With a basis in the above mentioned four lines of work, nine general recommendations for good practice for discard governance were identified. This document represents deliverable 7.3 of the DiscardLess project, and reports from task 7.2 “Good practice with implementing discard policies elsewhere”. A broad and global review of discard management practices (Karp, et al.) is in development and will be published as the first chapter in a planned edited book (to be published by Springer) on the landing obligation. The preliminary title for this work is: “Reducing discards in the world’s fisheries – examples of effective governance, collaboration and innovation, and avoiding impediments to success”. The outline this work is attached in Appendix I. The chapter will be finalized by May 2018.
POST-OPERATIVE NAUSEA VOMITING IN LAPAROSCOPIC CHOLECYSTECTOMY: A PROSPECTIVE, RANDOMIZED, DOUBLE BLIND COMPARATIVE STUDY OF RAMOSETRON AND ONDANSETRON

Introduction: Postoperative nausea and vomiting(PONV) is a distressing complication after anaesthesia, which should be prevented to accelerates postoperative recovery and patient satisfaction. Therefore this study was conducted to compare the efficacy and safety of ramosetron and ondansetron in patients undergoing standard laparoscopic cholecystectomy Methodology: This prospective, randomized, double blinded comparative study was carried out at department of Anaesthesiology, Medanta Abdur Razzaque Ansari Memorial Weavers' Hospital, Ranchi. Total of 168 patients undergoing laparoscopic cholecystectomy under general anaesthesia were randomized into group O and group R based on a computer generated random table to receive Ondansetron 4 mg IV and ramosetron 0.3 mg IV respectively. Patients were closely monitored for first 24 hour post-surgery for post-operative nausea and vomiting. Results: It is concluded that, prophylactic administration of single dose of ramosetron 0.3 mg iv has better efficacy and is more potent than single dose ondansetron 4 mg iv in reducing post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
Shrouded co morbidity of severe osteoporosis in a young female with Kartagener-Afzelius syndrome-An unrivalled case report

*Article History: Received: 04/07/2018 Revised: 13/07/2018 Accepted: 13/07/2018 DOI: https://doi.org/10.7439/ijbar.v9i7. 4834 Abstract A 23 year old young female presented with recurrent chest infection since childhood with joint pain, diagnosed as a rare congenital autosomal recessive case of Kartagener syndrome with severe osteoporosis.