Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of coronary revascularization by elective percutaneous coronary intervention on cardiac autonomic modulation assessed by heart rate variability: a single-center prospective cohort study.

OBJECTIVE To study the effects of coronary revascularization using elective percutaneous coronary intervention (PCI) on autonomic modulation assessed by heart rate variability measurement (HRV) in coronary artery disease (CAD) patients. METHODS A single-center prospective cohort study included 100 patients were included undergoing elective PCI excluding those with contraindication to contrast or dual antiplatelet therapy, atrial fibrillation or multiple premature beats, receiving anti-arrhythmic drugs and those who underwent previous PCI or coronary artery bypass graft (CABG). Short-term measurement of time domain parameters (mean, SDNN, RMSSD) and frequency domain parameters (LF component, HF component, LF/HF ratio) of HRV was performed at the same time of the day, pre-PCI, 24 hours and 6 months post-PCI by CheckMyheart™ handheld HRV device. 5-min HRV analysis software was used to interpret the data using standard methods of HRV measurement of the Task Force of The European Society of Cardiology (ESC) and The North American Society of Pacing and Electrophysiology. SYNTAX (SX) score was calculated before PCI and residual SYNTAX (rSS) score was calculated after PCI using SYNTAX score calculator software. RESULTS The mean age of the studied population was 56.89±10.75 years with 85% males. HRV time and frequency domain parameters showed a statistically significant improvement at different time intervals (before PCI, 24 hours and 6 months after PCI) (p-value <0.001). HRV time and frequency domain measures showed a statistically significant difference between time and frequency domain HRV parameters 24 hours and 6 months after PCI in patients who had complete revascularization (CR) with those who had incomplete revascularization (IR). (p-value <0.001). CONCLUSION Autonomic modulation in CAD patients was improved by coronary revascularization using PCI assessed by serial HRV measurement. Patients with CR had better autonomic modulation than those with IR assessed by HRV 24 and 6 months after PCI.
Intestinal microbiota and antibiotic-associated acute gastrointestinal injury in sepsis mice

Background: To investigate the changes of intestinal microbiota and metabolites in sepsis mice with acute gastrointestinal injury before and after the use of antibiotics, and to explore the possible effects of these changes on the body. Methods: Twenty-four 6-8-w-old SPF-grade C57BL/6J male mice were selected, and the mice were randomly divided into three groups. The mice were treated by tail vein injection for 3 days. The intestinal motility of mice after administration was detected. The mice feces were collected for 16S rRNA and Untargeted metabonomics detection. Results: The use of antibiotics in sepsis mice can change the composition of intestinal microbiota and metabolites. LD3, AD3 and LAD3 samples had significant differences in bacterial species. Desulfovibrio was the species with a significant difference in LAD3. In addition, we found that the composition of those intestinal microbiota were correlated with changes in intestinal motility. The untargeted metabolomics analysis showed that the fecal metabolites of LD3 and LAD3 samples were significantly different. In addition to the basic metabolites, Benzoic acid and 4-Hydroxybenzoic acid were also found, and Desulfovibrio was associated with them. Conclusions: The use of antibiotics in sepsis mice can lead to changes in the intestinal microbiota and metabolite levels, which may be related to the severity of acute gastrointestinal injury in sepsis mice. Inhibiting Desulfovibrio in the intestine and using Benzoic acid and 4-Hydroxybenzoic acid as a marker for the production of Desulfovibrio may reduce the inflammatory degree of acute gastrointestinal injury in sepsis.
Dynamic Functional Connectivity in the Main Clinical Phenotypes of Multiple Sclerosis

INTRODUCTION Dynamic functional connectivity (dFC) allows capturing recurring patterns (states) of interaction among functional networks. Here, we investigated resting state (RS) dFC abnormalities across the different clinical phenotypes of multiple sclerosis (MS) and assessed their correlation with motor and cognitive performances. METHODS RS fMRI and 3D T1-weighted MRI data were acquired from 128 MS patients (69 relapsing-remitting [RR] MS, 34 secondary progressive [SP] MS, 25 primary progressive [PP] MS) and 40 healthy controls (HC). RS fMRI data underwent independent component analysis and sliding-window correlations, to identify recurring dFC states and between-group dFC differences in the main networks. RESULTS DFC identified three recurring connectivity states: State 1 (frequency of appearance during fMRI acquisition=57%, low dFC strength), State 2 (frequency=19%, middle-high dFC strength) and State 3 (frequency=24%, high sensorimotor and visual dFC strength). Compared to HC, MS (as a whole), RRMS and PPMS patients exhibited lower State1/State 3 dFC (p=0.0001, corrected) between sensorimotor, cerebellar and cognitive networks, and some dFC increments (p=range 0.001-0.05, uncorrected) in sensorimotor, visual, default-mode and frontal/attention networks in States 2 and 3. Similar results were observed in SPMS vs RRMS patients. In MS, dFC decrease in sensorimotor, default-mode and frontal/attention networks were correlated with worse motor and cognitive performances. CONCLUSIONS MS patients exhibited overall lower dFC, and marginally higher dFC in sensorimotor/cognitive networks in the less-frequent middle/high-connected States. DFC abnormalities became more severe in progressive MS and correlated with motor and cognitive impairment, suggesting the presence of maladaptive mechanisms concomitant with accumulation of damage.
Complex interactions underlie the correlated evolution of floral traits and their association with pollinators in a clade with diverse pollination systems

Natural selection by pollinators is an important factor in the morphological diversity and adaptive radiation of flowering plants. Selection by similar pollinators in unrelated plants leads to convergence in floral morphology, or “floral syndromes. ” Previous investigations into floral syndromes have mostly studied relatively small and/or simple systems, emphasizing vertebrate pollination. Despite the importance of multiple floral traits in plant‐pollinator interactions, these studies have examined few quantitative traits, so their co‐variation and phenotypic integration have been underexplored. To gain better insights into pollinator‐trait dynamics, we investigate the model system of the phlox family (Polemoniaceae), a clade of ∼400 species pollinated by a diversity of vectors. Using a comprehensive phylogeny and large dataset of traits and observations of pollinators, we reconstruct ancestral pollination system, accounting for the temporal history of pollinators. We conduct phylogenetically controlled analyses of trait co‐variation and association with pollinators, integrating many analyses over phylogenetic uncertainty. Pollinator shifts are more heterogeneous than previously hypothesized. The evolution of floral traits is partially constrained by phylogenetic history and trait co‐variation, but traits are convergent and differences are associated with different pollinators. Trait shifts are usually gradual, rather than rapid, suggesting complex genetic and ecological interactions of flowers at macroevolutionary scales.
Long‐term changes in amplitudes of atmospheric CO2 concentrations at Ocean Station P and Alert, Canada

Atmospheric CO 2 concentrations sampled at Ocean Weather Station P and Alert, Canada, were analyzed for possible increase in the seasonal amplitudes. The sampled data sets were reduced by smoothing spline method to obtain mean monthly values. Each set of the monthly means was detrended with a 21-point moving-average filter, and then was fitted with a mixed additive-multiplicative model. The changing amplitudes of the seasonal components were adjusted with the local amplitude scaling factors which were estimated from seven-month moving regressions. Linear regression was used to estimate the rates of change of the amplitudes. Trends of the seasonal components were also approximated by regressing the scaling factors of the same calendar months on time increments. Our results suggest that the growth rate of CO 2 amplitudes was ∼ 1.4% yr -1 from 1971 to 1979 for Station P. However, the growth rate for Alert between 1977 and 1985 was about − 0.02% yr -1 , which is not statistically significant above zero. The different trends obtained are attributed mainly to the geographical differences in CO 2 sources and sinks, one of which may be the biosphere. Factors such as the winter-season photosynthesis, which probably is increasing and may be altering the CO 2 amplitudes, are discussed. DOI: 10.1034/j.1600-0889.1990. t01-4-00003.x
Impact of Automated Notifications on Prescription Abandonment

Background: Prescription abandonment impacts patients’ quality of life and disease progression. In addition, prescription abandonment can increase total healthcare costs. Objective: This study compared effects of automated telephone calls (ATC), automated text messages (ATM), and control on prescription abandonment rates with Medicare defined Star Rated medications. The secondary objective compared prescription abandonment rates between age groups (18-64 versus ≥ 65 years) within each arm. Methods: This was a retrospective observational analysis from a regional division of a large community-based pharmacy chain. Star Rated medication prescriptions consisting of hydroxymethylglutaryl-coenzyme A reductase inhibitors, renin-angiotensin system antagonists, and non-insulin type 2 diabetes mellitus medications were included. Prescriptions for patients who activated or deactivated automated notification enrollment during the study period were excluded. Results: A total of 31,056, 33,278, and 20,299 prescriptions were included in the analysis of ATC, ATM, and control arms, respectively. Prescription abandonment occurred on 726 (2.3%) prescriptions within ATC arm, 864 (2.6%) prescriptions within ATM arm, and 513 (2.5%) prescriptions within control arm (p = 0.099). Prescription abandonment occurred on 390 (2.6%) prescriptions for 18-64 and 336 (2.1%) prescriptions for 65 years or older within the ATC arm (p = 0.002). Prescription abandonment occurred on 251 (2.9%) prescriptions for 18-64 and 262 (2.3%) prescriptions for 65 years or older within the control arm (p = 0.006). Conclusion: No difference in rates of prescription abandonment existed between each automated notification arm on Star Rated medications. ATC notifications decreased rates of prescription abandonment when utilized by patients 65 years or older.
Synergistic effect in concurrent removal of toxic methylene blue and acid red-1 dyes from aqueous solution by durian rind: kinetics, isotherm, thermodynamics, and mechanism

Abstract In the present study, a synergistic effect between cationic methylene blue (MB) and anionic acid red 1 (AR1) on their concurrent adsorptive removal from aqueous binary solution onto durian rind (DR) was systematically investigated in batch mode across different parameters. The concurrent adsorption was pseudo-second-order kinetics and followed the Langmuir isotherm model, similar to their respective single component. The kinetics and intraparticle diffusion analyses demonstrated that the adsorption rate of MB was a 15-fold faster than AR1, and mass transports were governed by a combination of intraparticle and film diffusion. The synergistic effect was evidenced by an enhanced adsorption efficiency of AR1 from 27 to 42%, while that of MB was almost unchanged (97–98%). By changing the molar ratios of MB and AR1, it was found that the maximum adsorption capacity of MB and AR1 was 249 and 200 mg g−1, respectively, in the binary system higher compared with those in their respective single system (108 and 16 mg g−1). Overall data indicated that the synergistic effect was due to electrostatic interactions between cationic and anionic synthetic dyes, supported by negatively charged DR surface, leading to the formation of their stacking layers on the adsorbent surface. Novelty statement: A synergistic effect in concurrent adsorptive removal of synthetic dyes from multicomponent wastewater remains a critical research challenge. We believed that electrostatic interaction between ionic dyes could be explored to enhance their removal efficiency. This report is the first time that such a synergistic effect between cationic methylene blue (MB) and anionic acid red 1 (AR1) on their concurrent adsorption from aqueous binary system is systematically investigated. The kinetics, isotherm, thermodynamics, and mechanism of the concurrent adsorption of MB and AR1 attributed to the synergistic effect are elucidated in detail.
Longitudinal evaluation of multiple biomarkers for the detection of testosterone gel administration in women with normal menstrual cycle.

In women, hormonal fluctuations related to the menstrual cycle may impose a great source of variability for some biomarkers of testosterone (T) administration, which can ultimately disrupt the sensitivity of their longitudinal monitoring. In this study, the sensitivity of the current urinary and haematological markers of the Athlete Biological Passport (ABP), as well as serum steroid biomarkers was investigated for the monitoring of a 28-days T gel treatment combined with endogenous fluctuation of the menstrual cycle in 14 healthy female subjects. Additionally, the analysis of urinary target compounds was performed on a subset of samples for endogenous/exogenous origin via isotope ratio mass spectrometry (IRMS). In serum, concentrations of T and dihydrotestosterone (DHT) increased significantly during the treatment, whereas in urine matrix the most affected biomarkers were found to be the ratios of testosterone/epitestosterone (T/E) and 5α-androstane-3α,17β-diol/epitestosterone (5αAdiol/E). The detection capability of both urinary biomarkers was heavily influenced by [E], which fluctuated depending on the menstrual cycle, and resulted in low sensitivity of the urinary steroidal ABP module. On the contrary, an alternative approach by the longitudinal monitoring of serum T and DHT concentrations with the newly proposed T/androstenedione ratio showed higher sensitivity. The confirmatory IRMS results demonstrated that less than one third of the tested urine samples fulfilled the criteria for positivity. Results from this study demonstrated that the 'blood steroid profile' represents a powerful complementary approach to the 'urinary module' and underlines the importance of gathering bundle of evidence to support the scenario of an endogenous prohibited substance administration.
The biogeochemistry of technetium: A review of the behavior of an artificial element in the natural environment

Interest in the chemistry of technetium has only increased since its discovery in 1937, mainly because of the large and growing inventory of 99Tc generated during fission of 235U, its environmental mobility in oxidizing conditions, and its potential radiotoxicity. For every ton of enriched uranium fuel (3% 235U) that is consumed at a typical burn-up rate, nearly 1 kg of 99Tc is generated. Thus, the mass of 99Tc produced since 1993 has nearly quadrupled, and the pace of generation will likely increase if more emphasis is placed on nuclear power to slow the accumulation of atmospheric greenhouse gases. In order to gain a comprehensive understanding of the interaction of 99Tc and the natural environment, we review the sources of 99Tc in the nuclear fuel cycle and its biogeochemical behavior. We include an evaluation of the use of Re as a chemical analog of Tc, as well as a summary of the redox potential, sorption, colloidal behavior, and interaction of humic substances with Tc, and the potential for re-oxidation and remobilization of Tc(IV). What emerges is a more complicated picture of Tc behavior than that of an easily tractable transition of Tc(VII) to Tc(IV) with consequent immobilization. Reducing conditions (+200 to +100 mVEh) and the presence of Fe(II) sorbed onto Fe(III) (oxy)hydroxides will bring the mobile Tc(VII) species to a lower oxidation state and will form the relatively insoluble Tc(IV)O2 · nH2O, but even as a solid, equilibrium concentrations of aqueous Tc are nearly a factor of 20× above the EPA set drinking water standards. However, sequestration of Tc(IV) into Fe(III)-bearing phases, such as goethite, iron-bearing phyllosilicates and, perhaps, siderite, may ameliorate concerns over the mobility of Tc. A key factor, elucidated through experiment, in retarding the mobility of Tc in the environment is isolation from exposure to oxygen. One way to achieve isolation from oxygen occurs when Tc is locked in a crystallographic position in a solid phase.
Predictive factors for spontaneous stone passage in diabetic patients with acute ureteric colic

To the Editor: According to the data from the National Health andNutrition Examination Survey (2007–2010), the prevalence of kidney stones in the United States (US) population is 8.8%. A prior US population study has found that the prevalence of kidney stones increases with obesity, diabetes, and metabolic syndrome; for individuals with type2diabetes, the severityofdisease is associatedwitha greater risk of kidney stones. Choi et al reported that a diagnosis of diabetes was a significant predictive risk factor for failure of spontaneous stone passage (SSP) possibly secondary to ureteral edema and those diabetic patients should be considered for candidates for more invasive treatment. However, this study included only 26 diabetic patients, and only 31 of 366 patients failed to spontaneously pass their stones both ofwhichmay limit the power to predict SSP of diabetes. This is an important question to answer given the volume of stones in the US and the consequences of changes in SSP rates between patient groups. Therefore, through a retrospective analysis of the database of emergency renal colic visits in Cleveland Clinic Foundation, we evaluate the association of diabetes on SSP and investigated the predictive factors of SSP in diabetic patients.
Contamination and Bioaccumulation of Butyltin Compounds Inside Jeju Harbor of Jeju Island, Korea

Butyltin compounds in seawater, sediments and organisms inside Jeju Harbor of Jeju Island, Korea, were quantitatively determined to assess the extent of contamination and to evaluate the bioaccumulation in Thais clavigera (gastropod), Liolophura japonica and Cellana nigrolineata. In addition, imposex in T. clavigera was used to assess the sublethal effect of tributyltin compounds and its usage as a specific biomarker for these compounds was also studied. The main species in seawater was tributyltin (TBT) in March and June, monobutyltin (MBT) in August, but in sediments and organisms it was dibutyltin (DBT) and TBT, respectively, irrespective of survey time. TBT, the most toxic to aquatic organisms among BTs, was found at concentrations which were sufficient to have a serous effect on the sensitive organisms upon chronic exposure. The high correlations (r>0.7) between BTs indicated that DBT and MBT were mainly degraded from TBT based on antifouling paints and their sources were negligible. The sedimentary organic matters have little influence on the distribution of BTs in marine environment and the lipid content in T. clavigera showed a significant correlation with TBT concentrations. Measurement of imposex T. clavigera was expected to be a very helpful tool for preliminary survey of BTs prior to trace analysis of those.
Current classification systems and standardized terminology in cytopathology

The history of classification systems and the search for a unified nomenclature in cytopathology spans several decades and expresses the preoccupation of all those involved to make cytopathology a reliable diagnostic tool and a trusted screening method. Early classification schemes, applicable to exfoliative and aspiration cytology, attempted to set some basic standards for how non-gynecological cytopathology findings should be reported. While useful in establishing some basic guidelines, these were not specific to the various fields of non-gynecologic cytopathology, often burdened with specific problems. Cytopathology has evolved tremendously in the last couple of decades, undoubtedly boosted by the emergence of various classification schemes that, more than ever, are based on evidence gathered by professionals across the globe. The benefit of classification systems and standardized nomenclature in cytopathology is to provide useful, clear, and clinically relevant information for clinicians and ultimately to provide the best patient care. Standardized reporting systems make cytopathology reports more meaningful and robust. It now became standard that these include by default elements, such as adequacy criteria, diagnostic groups, risk of malignancy (ROM), and recommendations for patient management. In this brief review, we attempted to summarize how these classification schemes emerged and how they are reshaping the landscape of diagnostic cytopathology.
An open pilot study of an internet-delivered intervention targeting self-perceived residual cognitive symptoms after major depressive disorder

Abstract Residual cognitive symptoms are associated with reduced daily life functioning, quality of life and represent a risk factor for relapse of major depressive disorder (MDD). There are few studies targeting self-perceived residual cognitive symptoms after MDD. The current open pilot study examines clinical outcomes and feasibility of a novel internet-delivered cognitive enhancement treatment for mood disorders specifically tailored to target self-perceived residual cognitive symptoms after MDD. A total of 43 adults with self-perceived residual cognitive symptoms after MDD were included. Participants were assessed pre- and post-treatment and at 6-month follow-up. The intervention consists of 10 modules that includes psychoeducation, cognitive strategies, and attention training, coupled with weekly therapist guidance. Results showed a significant reduction from pre- to post-treatment in self-perceived residual cognitive symptoms (d = 0.98) and rumination (d = 0.63). Results remained significant at the 6-month follow-up (d = 1.06; d = 0.86). Reliable change in self-perceived residual cognitive symptoms were obtained in 60% of the participants from pre- to post-treatment. Completion rates (86%) and treatment satisfaction (97%) were high. This open pilot study supports that targeting self-perceived residual cognitive symptoms after MDD through internet-delivered cognitive enhancement therapy for mood disorders may be feasible and provide stable reductions in self-perceived residual cognitive symptoms and rumination.
CONTINUITY BETWEEN DISORDER AND ORDER IN THE SEQUENTIAL DEPOSITION OF PARTICLES

ABSTRACT In previous work we pointed out that clusters of particles built through sequential quenching show increasing degrees of order as the temperature is lowered. In the low-temperature limit, a two-dimensional model system with a nondegenerate ground state would result in a perfect crystal. The opposite, high-temperature, limit corresponds to the case of random sequential addition (RSA). In the present work we study the continuous evolution from disorder to order at intermediate states using a triangular well potential to represent particle interactions. We investigate radial and bond-orientation correlation functions and the bond order parameter as measures of the degree of crystallinity of the structures up to a reduced number density of 0.65, which is close to the jamming limit of RSA.