Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of 13-Hydroperoxyoctadecadienoic Acid (13-HPODE) Treatment on the Transcriptomic Profile of Poorly-Differentiated Caco-2 Cells

Dietary lipid peroxides (LOOHs) have been linked to gut pathologies including inflammatory bowel disease and cancer. As poorly differentiated (PDiff) intestinal epithelial (Caco-2) cells represent tumor cells and could model intestinal crypt cells, we investigated the cellular response of PDiff Caco-2 cells to the most common dietary LOOH, 13-hydroperoxyoctadecadienoic acid (13-HPODE), using RNA sequencing (RNA-seq). Further, we compared the results with the transcriptomic profiles of PDiff cells exposed to linoleic acid (LA) or hydrogen peroxide (H2O2). The results showed that 13-HPODE treatment induces expression of genes related to detoxification and several metabolic pathways including glycogen and amino acid metabolism, which may create a tumorigenic environment despite the downregulation of some proliferation-related genes. 13-HPODE also enhanced peroxisome proliferator-activated receptor signaling involved in lipid metabolism, homeostasis, and inflammation. Additionally, results indicated that 13-HPODE impacts ribosome biogenesis, phagosome, and mitochondrial function through disrupted electron transport chain, which may contribute to disease development or progression. RNA-seq results were validated using qRT-PCR. This study provides an understanding of PDiff Caco-2 cell response to 13-HPODE and the mechanisms by which 13-HPODE modulates cellular processes that may contribute to disease development or progression.
The role of knowledge, trust, and religiosity in explaining the online cash waqf amongst Muslim millennials

Purpose This study aims to determine the role of knowledge, trust and religiosity in influencing the intention to donate cash waqf online among Muslim millennials in Indonesia. Design/methodology/approach Using a framework based on the theory of planned behavior, primary data was collected from 418 Muslim millennials who domiciled in large cities in Indonesia and subsequently analyzed using the structural equation modeling method. Findings The main findings suggest that knowledge, trust and religiosity play a positive role in explaining the intention to donate cash waqf online among Indonesia’s millennials. Religiosity is found to be the most powerful factor in influencing attitude, while knowledge is the least significant factor influencing the attitude, which subsequently influences the intention to engage in online cash waqf. Social norms and perceived behavioral control are also positively influencing such intention. Practical implications These results imply that it is important for waqf institutions to reflect strong Islamic values in their cash waqf products and to more strongly communicate religious messages about the benefits of giving cash waqf to the millennials. It is also crucial to increase waqf literacy through appropriate campaigns. Moreover, they need to be more transparent and accountable to establish, maintain and enhance trust in their organizations. Overall, these findings are expected to provide insights enabling waqf institutions to devise effective marketing strategies for raising the level of online cash waqf donation in Indonesia. Originality/value This is thought to be one of the first studies to investigate the factors influencing online cash waqf donations among Muslim millennials in Indonesia.
An interdisciplinary mental wellbeing intervention for increasing flourishing: two experimental studies

ABSTRACT Positive Psychology Interventions (PPIs) have been shown to improve mental health, but little is known about their impact on the quantifiable experience of flourishing. Two experimental studies investigated whether the proportion of participants flourishing, assessed using the Huppert and So conceptual framework, could be increased through a 10-week online interdisciplinary intervention that combined strategies from positive psychology and lifestyle medicine. In Study 1 (n = 421), flourishing was significantly increased (p < 0.001) in the intervention but not the control group and was sustained at 12 weeks post-intervention. Study 2 (n = 458) showed that the addition of human support to the online intervention did not further improve its effectiveness at increasing flourishing. These studies demonstrate that online interdisciplinary interventions that incorporate positive psychology and lifestyle medicine strategies can increase human flourishing, irrespective of the addition of human support.
SOCIOLOGICAL ANALYSIS OF EDUCATION AND REDUCTION IN FAMILY SIZE IN KHYBER PAKHTUNKHWA-PAKISTAN

Purpose of the study: The present study examines the association between education and reduction in family size in district Peshawar. Methodology: The results are based on the data gathered from 384 sampled respondents belonging to 6 communities that included 3 each from rural and urban areas of District Peshawar. The chi-square test was applied for statistical analysis. Main Findings: The study found a positive trend among the sampled families towards the decrease in family size which found the norm in the selected area where many respondents were still considering a large number of children as the blessing of Almighty Allah. The major role this regard was played by the education of the sampled respondents through generating more awareness about small family size along with increased exposure to norms favoring a decrease in family size. It was also influenced by more communication among the sampled couples. The education further enabled the sampled respondents to get more information about family planning and the institutions designed to promote family planning in Pakistan. It ultimately motivated the respondents to use contraceptives to decrease family size. Applications of this study: The study recommends promoting and enhancing the trend through a campaign for bringing a change in the attitude and action of the people towards making a family size required for the country. The originality of this study: This study will be helpful for policy Implications.
Sharing in the Family System: Contributions of Parental Emotional Expressiveness and Children’s Physiological Regulation

SYNOPSIS Objective . The current study examines whether associations between mothers’ and fathers’ emotional expressiveness and children’s observed sharing behavior differ for two young children in the same family and whether children’s baseline respiratory sinus arrhythmia (RSA) moderates relations between emotional expressiveness and sharing. Design . Altogether 69 families, including mothers, fathers, older siblings (Mage = 57.52 months), and younger siblings (Mage = 32.68 months) participated. Multilevel Poisson models were used to account for nesting of children within families and the count outcome of sharing. Results . Mothers who reported expressing more positive emotion had children who shared more, and this effect was moderated by child baseline RSA such that mothers who reported expressing more positive emotions had children who shared more when children had lower levels of baseline RSA. This finding was not significant for children with higher levels of baseline RSA or for fathers. Conclusions . Variations in the family’s emotional climate across individual members may be crucial to foster sharing behavior for children with lower levels of physiological regulation.
Marriage contributes to higher obesity risk in China: findings from the China Health and Nutrition Survey

Background To investigate the association between marriage and the prevalence of overweight and obesity in China. Methods We conducted cross-sectional and retrospective cohort analyses using a nationwide sample of 36,310 individuals from the China Health and Nutrition Survey [2004–2015]. Results The prevalence of overweight and obesity increased from 28.7% to 36.7% and from 8.0% to 14.5% between 2004 and 2015, respectively. The cross-sectional analysis showed that married individuals were at a higher risk of being overweight (OR =2.18; 95% CI, 1.90–2.51) or obese (OR =1.95; 1.57–2.43) than never-married individuals. Divorced/widowed individuals were also at a greater risk of being overweight (OR =1.80; 1.51–2.13) or obese (OR =1.67; 1.28–2.17) than never-married individuals. Retrospective cohort analysis showed that individuals who married during the study were 1.55 (1.13–2.11) times more likely to be overweight than those who remained never-married. Compared to those who remained never-married, individuals who remained married were 1.71 (1.42–2.07) and 1.45 (1.11–1.89) times more likely to be overweight and obese. Individuals who became divorced or widowed were more likely to be overweight (RR =1.59; 1.18–2.15) or obese (RR =1.63; 1.08–2.46) than those who remained never-married. However, the risk of being overweight or obese among those who became divorced or widowed did not differ significantly from the risk among those who remained married. Conclusions Marriage contributes to an increased risk of overweight and obesity in China; however, this risk is not significantly reduced by exiting a marriage.
Study of lipid profile in β thalassemia major pediatric patients with multiple blood transfusion and its correlation with serum ferritin level in tertiary care hospital in Kolkata

β-thalassemia major is associated with ineffective erythropoiesis, bone marrow expansion and rapid destruction of erythrocytes. Children with β-thalassemia major become symptomatic from progressive anemia with profound weakness and demands frequent blood transfusion. Regular blood transfusion and chelation therapy increases the survival time in patients because βthalassemia major patient unable to make enough healthy haemoglobin. So they are dependent on frequent blood transfusion that leads to iron overload manifested by increased serum ferritin levels. This secondary iron overload also due to increase absorption of iron from gut. Transfusion-induced hemosiderosis becomes the major clinical complication of transfusion-dependent thalassemia. Each ml of packed red cells contains approximately 1 mg of iron. Physiologically, there is no ABSTRACT
General model for biological nutrient removal activated‐sludge systems: model presentation

The development of a general model for biological nutrient removal in activated sludge systems is discussed. The general model is a mechanistic model based on the International Association on Water Pollution Research and Control (IAWPRC) (now IAWQ) model for carbonaceous energy removal, nitrification, and denitrification (Activated Sludge Model No. 1 [ASM1]), and the Wentzel et al. (1989a and b) model for biological phosphorus removal, with a number of modifications. A fermentation process has been included for the conversion of readily biodegradable chemical oxygen demand (COD) to short‐chain fatty acids (assuming a loss of COD from the system). Hydrolysis of enmeshed slowly biodegradable COD under anoxic and anaerobic conditions has been incorporated, as well as anoxic growth of polyP organisms. These modifications and others are discussed in this paper. The matrix representation and a description of the model processes are also presented, as well as a brief outline of influent wastewater characterization.
The Effect of Resistance Training with Royal Jelly on Serotonin and Dopamine Receptors Genes Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

Background Studies have shown that exercises and the use of natural foods have favorable effects on Alzheimer's disease (AD). The purpose of this study was to investigate the effects of resistance training (RT) with royal jelly (RJ) on serotonin and dopamine receptors expression in hippocampal tissue of rats with AD. Methods In this experimental study, 56 rats with AD were randomly divided into (1) control, (2) RT, (3) RT + 100 mg/kg RJ, 4) RT + 200 mg/kg RJ, 5) 100 mg/kg RJ, 6) 200 mg/kg RJ2 and 7) sham. Also in order to review the effects of AD induction on serotonin and dopamine, 8 healthy rats selected as healthy control group. During 8 weeks the groups 3, 4, 5 and 6 received daily RJ with specific doses peritoneally and groups 2, 3 and 4 performed RT three sessions per week with 30–100 percentage of body weight. Independent sample t- test, One way ANOVA and two-way ANOVA was used to investigate the effect of RT, RJ and interaction of RT and RJ also Bonferroni’s post- hoc test was used to evaluate the difference between the doses of RJ using SPSS software (P ≤ 0.05). Results RT had a significant effect on the increase of dopamine (p = 0.001) and serotonin receptors (p = 0.001); RJ had a significant effect on the increase of dopamine receptor(p = 0.01) and serotonin (p = 0.001) also RT simultaneously with RJ consumption had a significant interactive effect on the increase of serotonin receptor (p = 0.001). Conclusion It appears that RT and RJ can enhance serotonergic and dopaminergic function in hippocampal tissue of rats with AD, however, the effects of RJ seems to be dose dependent.
A deliberate language policy or a perceived lack of agency: Heritage language maintenance in the Polish community in Melbourne

Aims: By applying the tripartite framework of family language policy, this study seeks to gain insight into heritage language maintenance of Polish families in Melbourne. To this end, an integrative investigation of family language policy encapsulating the heritage language perceptions, practices and management will be employed. Methodology: Based on the data collected through the online questionnaire supplemented with in-depth interviews, quantitative and qualitative analyses have been conducted to obtain a sociolinguistic picture of the convoluted dependencies. Data and analysis: The interviews were recorded, transcribed verbatim and coded according to the grounded theory approach. The recurrent themes were noted. The existing social patterns were conceptualised through the process of constant comparison. The excerpts selected for analysis illustrate how critical have been the informants’ beliefs and practices concerning heritage language maintenance. Findings and conclusions: The data analyses of the researched families disclose a wide range of practices where certain discrepancies are observed between declarations and the actual language behaviours. It also emerges that without parents’ reinforcement and establishing the heritage language as a default means of communication at home, children suffer from lower productive skills. Originality: This paper delves into how Polish is maintained as a heritage language by the second generation of Polish-speaking immigrants. It explores the Polish community, one of the well-established yet understudied groups that make up multicultural Australia. It unfolds an account of the dynamics of family language policy, illustrating how they are constantly negotiated, contested and formed by parents. Significance/implications: The findings contribute to the ongoing discussion of language policies and heritage language maintenance by demonstrating that the hardship and distress resulting from heritage language acquisition as well as language maintenance are incumbent primarily on family language policy. The researched group is an average-size immigrant community situated in the context with limited institutional support resolving down to Polish Saturday schools.
Correlation between Structural and Transport Properties of Ca-Doped La Nickelates and Their Electrochemical Performance

This work presents the results from a study of the structure and transport properties of Ca-doped La2NiO4+δ. La2−xCaxNiO4+δ (x = 0–0.4) materials that were synthesized via combustion of organic-nitrate precursors and characterized by X-ray diffraction (XRD), in situ XRD using synchrotron radiation, thermogravimetric analysis (TGA) and isotope exchange of oxygen with C18O2. The structure was defined as orthorhombic (Fmmm) for x = 0 and tetragonal (I4/mmm) for x = 0.1–0.4. Changes that occurred in the unit cell parameters and volume as the temperature changed during heating were shown to be caused by the excess oxygen loss. Typical for Ruddlesden–Popper phases, oxygen mobility and surface reactivity decreased as the Ca content was increased due to a reduction in the over-stoichiometric oxygen content with the exception of x = 0.1. This composition demonstrated its superior oxygen transport properties compared to La2NiO4+δ due to the enhanced oxygen mobility caused by structural features. Electrochemical data obtained showed relatively low polarization resistance for the electrodes with a low Ca content, which correlates well with oxygen transport properties.
The effect of police searches and move-on directions on property and violent crime in New South Wales

The New South Wales (NSW) Law Enforcement (Powers and Responsibilities) Act 2002 gave the NSW Police the power in certain circumstances the power to stop, search and detain a person without warrant. The same legislation gave the police the power to direct a person to move on from a place if they believe on reasonable grounds that the person in question is obstructing traffic or another person; engaging in behaviour that is considered harassment or intimidation to another person (or people); behaving in a way that is causing or likely to cause fear to a reasonable person or present in the place in order to unlawfully supply or cause another person to unlawfully supply drugs. The exercise of these powers has attracted considerable controversy, but little is known about their effectiveness in controlling crime. We investigate the relationship between police activity and crime using panel data of 17 Local Area Command for the period 2001 to 2013. We find a significant and strongly negative long-run relationship between both indices of police activity and each of break and enter, motor vehicle theft and robbery. No significant long-run relationship is found between assault and move-on directions. The person search activity is negatively related to assault, but the effect is weak; with a 10% increase in person search only resulting in a 0.5% fall in assaults. The implications for the exercise of police move-on and search powers are discussed.
Teachers’ experiences of classroom behaviour problems and mitigation strategies among students with visual disabilities in Ghana

ABSTRACT Behaviour problems among students with visual disabilities are mentioned as a challenge confronting teachers. This study explores teachers’ experiences of behaviour problems and strategies used to mitigate such problems among students with visual disabilities in Ghana. In-depth interviews were conducted with 15 purposively selected teachers. Thematic analysis was used to analyse the data. The findings are discussed using a psychological theory, namely the biological theories and psychodynamic theories. The study shows that students exhibit several classroom behaviour problems, categorised into physiological (emotional problems, noncompliance and aggression) and physical and social problems (verbal abuse, sleeping, talking, habitual lateness and teasing). Factors causing behaviour problems are negative attitudes of teachers, unfavourable teaching methods, the nature of the family, and classroom environment. The study concludes that behavioural (rewards and motivation, punishment, and classroom rules and regulations), humanistic (positive student-teacher relationship) and systemic (participatory teaching strategy and resource persons) approaches can be employed as mitigation strategies.
Trade Effects of Eurasian Economic Union and Global Production Sharing: A Gravity Analysis

This study examines the effects of the Eurasian Economic Union (EAEU) on global production sharing and trade in parts and components. With a panel dataset of disaggregated bilateral exports of EAEU members and 28 partners, we estimate an augmented gravity model for 2010–2017. To mitigate endogeneity issues, we employ the Hausman and Taylor Estimator. The study has two important findings. First, there are significant trade diversion effects on the exports of parts and components. Second, the formation of EAEU has resulted in a reduction in intra-bloc exports. In addition to these, we find that market size, inter-country differentials of income, business-friendly climate, and cultural similarities are the other significant determinants of bilateral trade. Based on the empirical analysis, we propose that the EAEU normalise the Common External Tariff below the current level to minimise trade diversion.
User-Defined Gestures for Mid-Air Interaction: A Comparison of Upper Limb Muscle Activity, Wrist Kinematics, and Subjective Preference

ABSTRACT Traditional gesture elicitation studies generally adopted the frequency ratio to select popular gestures among users. However, the chosen gestures were not always optimal and might pose a potential risk of musculoskeletal disorder under long-term use. The purpose of our research was to apply a novel assessment system combining the indices of electromyography (EMG), electrogoniometry, and subjective preference to the end-user elicitation experiment. In this study, we conducted a two-stage experiment to compare and analyze the results of the physiological and psychological measures for 33 candidate gestures of 16 given commands. Our results indicated that this assessment system could effectively determine the candidate gestures with lower physiological loads for all given commands except Maximize, and most of the selected gestures were in line with users’ mental models. Finally, we developed an optimal user-defined gesture set for the commands accommodated to human-computer interaction (HCI).
Digitalised talent management and automated talent decisions: the implications for HR professionals

Abstract Our study examines the role digitalisation plays in how various stakeholder groups (HR and line managers) identify talent and whether digitalisation transforms the role of HR professionals in identifying talent. By employing a qualitative case study with multiple embedded units of analysis, we show how the same digital talent management technology produced different ways of identifying talent even within the one organisation. In one social context, the material properties of the technology dominated, while in another the existing social context and relationships prevailed over the material properties of the technology. Our findings have implications for understanding digital transformations by acknowledging what factors influence the role that digitalisation and automation have on the perceived legitimacy of HR professionals. We discuss these implications for talent management scholarship and the HR profession.
Biodegradation Study of Magnesium-based Implant Materials under Physiological Conditions

Biodegradable magnesium and its alloys are new-generation materials for orthopaedic implants. In vitro setups utilising physiological conditions are promising for material/degradation analysis prior to animal experiments. The work of this study is divided into two parts. In part 1, the influence of important blood plasma salts on pure magnesium degradation and its product composition was elucidated first in Hank’s Balanced Salt solution without calcium or magnesium (HBSS) and then in complex cell culture media; Dulbecco’s Modified Eagle’s Medium (DMEM) and Roswell Park Memorial Institute medium (RPMI-1640). In part 2, the direct influence of osteoblast cells on the degradation of pure magnesium and two alloys, Mg-2Ag and Mg-10Gd was studied. The degradation layer was analysed with Electron-Induced X-ray Emission (EIXE) spectroscopy and Fourier Transform Infrared Reflection micro-spectroscopy (FTIR). The degradation interface (directly beneath the cells) was analysed with a new approach that uses a scanning electron microscope equipped with energy-dispersive X-ray and a focused ion beam. The results highlight the importance of bicarbonate as a blood-buffering salt on the formation of magnesium carbonate as main degradation product. Deposition of calcium phosphate precipitations reduced the degradation. Results also indicate the role of osteoblasts in altering the chemical composition by forcing apatite precipitations.