Miracle-dz/UniFAR-FTUs huggingface dataset:
An Immune-Related Prognostic Signature for Predicting Clinical Outcomes and Immune Landscape in IDH-Mutant Lower-Grade Gliomas

Background IDH mutation is the most common in diffuse LGGs, correlated with a favorable prognosis. However, the IDH-mutant LGGs patients with poor prognoses need to be identified, and the potential mechanism leading to a worse outcome and treatment options needs to be investigated. Methods A six-gene immune-related prognostic signature in IDH-mutant LGGs was constructed based on two public datasets and univariate, multivariate, and LASSO Cox regression analysis. Patients were divided into low- and high-risk groups based on the median risk score in the training and validation sets. We analyzed enriched pathways and immune cell infiltration, applying the GSEA and the immune evaluation algorithms. Results Stratification and multivariate Cox analysis unveiled that the six-gene signature was an independent prognostic factor. The signature (0.806/0.795/0.822) showed a remarkable prognostic performance, with 1-, 3-, and 5-year time-dependent AUC, higher than for grade (0.612/0.638/0.649) and 1p19q codeletion status (0.606/0.658/0.676). High-risk patients had higher infiltrating immune cells. However, the specific immune escape was observed in the high-risk group after immune activation, owing to increasing immunosuppressive cells, inhibitory cytokines, and immune checkpoint molecules. Moreover, a novel nomogram model was developed to evaluate the survival in IDH-mutant LGGs patients. Conclusion The six-gene signature could be a promising prognostic biomarker, which is promising to promote individual therapy and improve the clinical outcomes of IDH-mutant gliomas. The study also refined the current classification system of IDH-mutant gliomas, classifying patients into two subtypes with distinct immunophenotypes and overall survival.
Evaluation of thyromental height test in prediction of difficult airway in obese surgical patients: An observational study

Background and Aims: Thyromental height test (TMHT) has revealed good potentials for predicting difficult laryngoscopy view (DLV) in non-obese patients, but its accuracy in obese patients is not evident. This study aimed to assess the validity of TMHT as a predictor of DLV in obese surgical patients. Methods: 105 patients, aged 18–60 years, with body mass index (BMI) >30 kg/m2, scheduled for elective surgeries under general anaesthesia with an endotracheal tube inserted using conventional laryngoscope were included. Airway was assessed with TMHT, modified Mallampati test (MMT), neck circumference (NC) and NC/TMHT ratio. The DLV was defined as Cormack–Lehane grade ≥3. The primary endpoint was the validity of TMHT as a predictor of DLV. The secondary endpoints were to compare the accuracy of TMHT with that of the NC, MMT and NC/TMHT ratio as predictors of the difficult airway. Results: The BMI was 43.7 ± 6.6 kg/m2. The DLV cases were 23/105 (21.9%). The MMT, TMHT and NC/TMHT ratio had the best predictive ability of DLV with areas under receiver operating characteristic curve of 0.91, 0.92 and 0.80; at cut-off values >2, <47 mm and >7.9, respectively. MMT and TMHT were the only predictors of DLV by multivariate analysis. Conclusion: In obese surgical patients, TMHT is an excellent predictor of DLV when the cut-off value is <47 mm.
Semiconductor Device Simulation

Two of the numerical methods most widely used in solving the set of partial differential transport equations for holes, electrons, and electric field in semiconductor devices and the various numerical instability phenomena which can be encountered are described in detail. Also presented are approaches, using these methods, to calculate dc static solutions and small-signal solutions, and to simulate devices in voltage-driven, current-driven, and circuit-loaded operation. Sample results are given for each mode of operation for the case of Si avalanche-diode oscillators. The numerical methods and approaches are those developed at our laboratory and sufficient detail is presented to permit the development of similar Fortran codes by others.
Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells

Mechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic differentiation and microvesicle release from human embryonic stem cells (hESCs) and human bone marrow stem cells (hBMSCs) are examined. hESCs were differentiated into chondroprogenitors and then embedded in fibrin gels and subjected to HP (270 kPa, 1 Hz, 5 days per week). hBMSC pellets were differentiated in chondrogenic media and subjected to the same regime. HP significantly enhanced ACAN expression in hESCs. It also led to a significant increase in DNA content, sGAG content and total sGAG/DNA level in hBMSCs. Furthermore, HP significantly increased microvesicle protein content released from both cell types. These results highlight the benefit of HP bioreactor in promoting chondrogenesis and EV production for cartilage tissue engineering.
Functional connectivity and information pathways in the human entorhinal-hippocampal circuitry

Cortical processing streams for item and contextual information come together in the entorhinal-hippocampal circuitry. Various evidence suggest that information-specific pathways organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and subiculum. Our data show specific scene processing in the functionally connected posterior-medial EC and distal subiculum. The regions of another route, that connects the anterior-lateral EC and a newly identified retrosplenial-based anterior-medial EC subregion with the CA1/subiculum border, process object and scene information similarly. Our results support topographical information flow in human entorhinal-hippocampal subregions with organized convergence of cortical processing streams and a unique route for contextual information. They characterize the functional organization of the circuitry and underpin its central role in memory function and pathological decline.
Effects of Planting Density and Weeding Frequency on the Corn Growth and Yield in Intercropping System with Peanut

The research aimed to determine the optimal population ratio at each frequency of weeding for the growth and yield of maize. It was carried out from February to May 2020 in the field. There are 2 treatment factors tested arranged in a splite plot design, which was repeated 3 times using a completely randomized block design (CRBD). The first factor is the frequency of weeding as the main plot (Main Plot) consisting of no weeding, 1 x weeding (21 DAS), 2 x weeding (21 DAS and 42 DAS). The second factor is the ratio of the population as sub-plots, consisting of 100% corn + 0% peanuts, 80% corn + 20% peanuts, 60% corn + 40% peanuts, 40 % corn + 60% peanuts, 20% corn + 80% peanuts. The results showed that the growth and yield of maize in the intercropping system with peanuts gave the same response to the population ratio at all weeding frequencies. The planting density of 40% maize + 60% peanuts produced the highest response on the variables of stem diameter (24.675 mm), plant fresh weight (667.51 grams) and biomass weight (79.924 grams). While the highest response to weeding frequency was 2 times (21 DAS and 42 DAS) only on plant fresh weight (588.08 grams).
Assessment of Subclinical Left Ventricular Systolic and Diastolic Dysfunction in Patients with Type 1 DM with and without Good Metabolic Control

Background: Diabetic patients with normal left ventricular ejection fraction (LVEF)are frequently associated with diastolic dysfunction. However, LVEF is known not to be a sensitive marker for the detection of subclinical LV systolic dysfunction. This study aimed to assess left ventricular systolic and diastolic function in asymptomatic type 1 diabetic patients by conventional, tissue Doppler and two-dimensional speckle tracking echocardiography to assess subclinical left ventricular systolic and diastolic dysfunction. Methods: Case-control study was conducted at 150 patients aged 15-35 y were subdivided into three equal groups: Group A: with type 1 diabetes mellitus (T1DM) with good metabolic control (Hb A1C <7.0), Group B: T1DM with poor metabolic control (Hb A1C>7.0), and Group C: Control group: included 50 normal healthy subjects. Results: Tissue Doppler, diastolic function and strain parameters, AP4C LS, AP2C LS, AP3C LS, and GLS were significantly impaired among the three groups. AP4C LS, AP2C LS, AP3C LS, and GLS were significantly lower in group B than group A and group C and was significantly lower in group A than group C, A velocity was significantly impaired among the three groups. A velocity was significantly higher in group B than group A and group C and was insignificantly impaired in group A than group C. Conclusion: Conventional echocardiography parameters were insignificantly different between the study groups. 2D speckle tracking and tissue Doppler echocardiography showed that subclinical left ventricular systolic function may be affected even before affection of diastolic function. Longer duration and poor glycemic control of diabetes significantly affect GLS.
Case Study of Morton Effect Shaft Differential Heating in a Variable-Speed Rotating Electric Machine

Hydrodynamic journal bearings can exhibit a particular form of Shaft Differential Heating (SDH) sometimes known as the Morton Effect. This paper presents test data of the Morton Effect in the form of synchronous spiral vibration observed in a 4200 rpm rotating electric machine. With its original partial arc bearings, divergent spiral vibration prevented stable operation above 4000 rpm. Subsequent analytical SDH studies of different bearing types are described which led to a switch to 4 lobe sleeve bearings. The 4 lobe bearing retrofit eliminated the unstable spiral vibration behavior. To the authors’ knowledge, this is the first published instance of a verified case of the Morton Effect to be solved exclusively by a change in bearing hardware with no accompanying changes to the rotor, shaft or journal.Copyright © 2011 by ASME
An internal combustion engine platform for increased thermal efficiency, constant‐volume combustion, variable compression ratio, and cold start

An internal‐combustion engine platform, which may operate on a portfolio of cycles for an increased expansion ratio, combustion under constant volume, variable compression ratio, and cold start, is introduced. Through unique thermodynamic cycles, the engine may be able to operate on a much greater expansion ratio than the compression ratio for a significantly improved thermal efficiency. This improvement is attained without involving a complex mechanical structure or enlarged engine size, and at the same time without reducing the compression ratio. The engine with these features may serve as an alternative to the Atkinson cycle engine or the Miller cycle engine. Furthermore, based on the same engine platform, the engine may operate on other cycles according to the load conditions and environmental considerations. These cycles include those for combustion under constant volume, variable compression ratio under part load conditions, and cold start for alternative fuels.
The influence of the introduction of rice bran on fermented milk drink

Rice bran is an agro-industrial waste with excellent nutritional value and a considerable content of bioactive compounds. Biotransformation processes by fermented milk drink fermentation increase the interest in obtaining products from agro-industrial wastes with good biological properties. The viability of introducing rice bran (RB) into fermented milk drinks to improve the structural stability and sensory was studied. Fermented milk drink supplemented with 0, 0.1 %, 0.3 %, 0.5 %, 0.7 % amount of RB were studied. Samples were stored for 28 days at 4 ± 1 °C. Samples composition was studied, Physicochemical properties (total titratable acidity, apparent viscosity, and pH) and consumer’s acceptability of fermented milk drinks were determined at 0, 7th, 14th, 21th and 28th days of storage. Studies showed that rice bran wan rich in dietary fiber (28.57 %), fat (21.56 %), and protein (11.18 %). The introduction of RB showed a significant influence on these parameters (P < 0.05). The introduction of RB would significantly improve the value of titratable acidity and apparent viscosity and decrease pH value. The more rice bran was added, the higher the values of titratable acidity and apparent viscosity were. The lower the pH value was, which could shorten the fermentation time, improve the texture stability, save production cost. The storage period could significantly influence the value of titratable acidity, pH, and apparent viscosity. The longer the storage period was, the higher the titratable acidity values were, the lower the pH value was caused by the post-fermentation of fermented milk drink. The apparent viscosity showed a trend of rising first and falling then during the storage period. The introduction of RB could significantly influence the sensory characteristic (color, consistency, sour, and texture). The introduction of RB would lead to whey separation and rough structure. Fermented milk drink supplemented with 0.1 % RB showed higher sensory acceptance. The best shelf life of the sample is 14 days，during which time fermented milk drink was of the best quality. RB is a kind of raw material with bright application prospects in a fermented milk drink.
High performance single frequency fiber grating-based erbium/ytterbium-codoped fiber lasers

The device characteristics of Er/sup 3+/,Yb/sup 3+/ single frequency fiber lasers are reported. A 5-cm long 1550-nm distributed feedback fiber laser with 4 mW output power is shown to have excellent specifications in terms of optical linewidth, signal-to-noise ratio (SNR), relative intensity noise, side-mode suppression and polarization purity. For higher power applications, a 1.5 cm single frequency Er/sup 3+/,Yb/sup 3+/ grating-based fiber laser with 60 mW output power and a net efficiency of 12% is demonstrated.
Effect of the bracketless orthodontics technique and resin composite material on the biomechanical response of the upper central incisor: 3D finite element analysis

The bracketless orthodontic treatment (BOT) is an alternative technique which indicates using an orthodontic appliance composed of wires and composite resin assisted by 3D technology. However, the biomechanical response of central incisor orthodontic movement has yet to be investigated. Thus, the aim of the present investigation was to calculate the stress magnitude in central incisor movement through 3D finite element analysis using different wire diameters (0.012”, 0.014”, and 0.016”) of nickel–titanium wire and two different resin composites (Opallis and Filtek). A 3D volume composed of enamel, dentin, cortical bone, cancellous bone, periodontal ligament, composite resin, and different orthodontic wire diameters was designed. After the modeling process, the models were exported to computer-aided engineering software divided into a finite number of elements, and a mechanical structural static analysis was conducted. The stress results were plotted on colorimetric maps and in tables for comparison between the different models. The results showed that the central incisor orthodontic movement with BOT does not induce damage to the periodontal ligament, dental root, or bone tissue, regardless of the simulated orthodontic wire diameter and resin composite materials. The palatal composite resin and orthodontic wire also presented acceptable stress magnitude during orthodontic movement. Thus, the BOT technique promoted a suitable biomechanical response during central incisor movement regardless the resin composite.
Can Technology Improvements Cause Productivity Slowdowns?

We explore two channels through which increases in the rate of investment-specific technological change can lead to decreases in measured productivity growth. The first channel is learning; with an increase in the rate of adoption more resources are devoted to new technologies where experience is low. As a result, labor productivity and TFP growth fall temporarily. Second, if the unmeasured quality of final outputs depends significantly on capital input, then declines in productivity growth will be recorded as the growth rate of capital goes up. We document the recent productivity slowdown in the United States and elsewhere and discuss evidence suggesting that an increase in the rate of investment-specific technological change may have occurred at about the same time as the slowdown began. We then use a simple, parameterized vintage capital model in order to gauge the potential importance of this phenomenon for productivity measurements.
Acousto-optic null steering processor (AONSP): initial hardware results and observations

After reviewing the function of a Multiple Sidelobe Canceler in a typical radar application and providing an overview of the goals and architecture of the Acousto-Optic Null Steering Processor program, this paper describes the hardware configuration of the breadboard model and reports the performance of this system to date. Significant design issues and experimental observations are discussed. Some of these design issues have been discovered during breadboard evaluation; others were predicted by simulation and have been verified experimentally. This paper concludes by identifying those areas where the greatest potential for performance improvement lies.
Information behavior and practices research informing information systems design

Information behavior and practices (IBP) research has been repeatedly criticized for having little impact on information systems development (ISD). Claiming that there is a complete disconnect would be an exaggeration but it is apparent that it is not always easy to translate findings of IBP research to workable design recommendations. Based on a reading of earlier literature and a closer investigation of three illustrative example contexts, this article underlines that the value of IBP research for ISD lies in its capability to inform ISD of the variety of ways people deal with information beyond individual systems, their own wants and designers' assumptions. Moreover, it highlights that the implications of information systems go beyond their primary users. Instead of overemphasizing the contextuality of findings, a part of IBP research would benefit from an increased focus on explicating its epistemological extents and limits and identifying, which findings are transferable, what distinguishes specific contexts, what are their defining constraints and priorities, and what aspects of their uniqueness are assumptions and simple clichés.
The social life of data: strategies for categorizing fluid and multiple genders

ABSTRACT Accurate data collection from LGBTIQ+ communities is crucial for public health research and the provision of equitable services. Emergent fluid, multiple, trans and non-binary gender identities complicate data collection in ways that make an excellent case-study for rethinking the categorization of such data. In this article, we explore some of the obstacles to collecting data from trans, gender-diverse and non-binary (TGD) communities, and the difficulties in synthesizing meaning about fluid or multiple identity categories. We review a selection of international surveys from the last 10 years and then present a case-study of data collection in an Australian mixed-methods study of LGBTQ+ young people’s uses of social media. In doing so we draw upon trans and gender diverse people’s lived experiences to reinterpret our survey dataset in which responses that ‘refused categorisation’ were initially removed. We argue that theorizing the ‘social life of data’ – that is analysing the disciplinary orientation and purpose of research, while also acknowledging the moment and site of data collection, the methods used, and the mutable meanings in play – better accounts for the lived experiences of gender beyond binary and static identities.
Capturing Secondary Cavitation – A Step Towards Numerical Assessment of Cavitation Nuisance

Abstract Numerical simulations using incompressible Large-Eddy Simulation together with a mixture assumption and a finite-rate mass transfer model demonstrate the presence of several cavitation mechanisms important for cavitation nuisance of hydrodynamic machinery such as marine propellers and power turbines. One of such mechanisms is brought about by re-entrant jets, which can cut sheet cavities and thus lead to shedding and travelling cavities which in turn may cause nuisance as they collapse. However, severe erosion and noise generation also stem from the formation and development of small scale structures called secondary cavitation, formed e.g. in shear layers through vortex roll-up, which are also important for cavitation nuisance risk. The extent of the resolution of the secondary cavitation in the computational setting is discussed. Cavitation on a NACA0015 foil at 6° angle of attack and σ = 1.0 in a three-dimensional domain is studied.
The Chinese National Top Level Courses Project: Using Open Educational Resources to Promote Quality in Undergraduate Teaching

The Top Level Quality Project (jingpin kecheng, 精品课程) is a large project in Chinese higher education which uses the production of Open Educational Resources to improve the quality of undergraduate education. Widely understood in the West to be a form of OpenCourseWare inspired by MIT’s example, this thesis traces the roots of the project back to the history of Russian influence on Chinese higher education, the introduction of course evaluation systems in 1985, a string of large-scale funding projects to promote excellence in the 1990’s, and the massification of higher education from 1988 to 1998. After a detailed description of the project, the thesis suggests that university teaching is conceptualized very differently in North America and in China, drawing parallels both to the historical French and German models of the university, and to the Chinese tradition of using “models” to promote virtue and excellence.
Assessment of groundwater quality of two selected villages of Nawada district of Bihar using water quality index

Unplanned discarding of industrial effluent, sewage, domestic and industrial solid waste, unwise use of insecticides, herbicides, pesticides, and fertilizer in agriculture are the major causes of groundwater quality reduction. In the present paper groundwater quality of the two selected village of Rajauli subdivision of Nawada district of Bihar was assessed using water quality index (WQI). The samples were figured out for the parameters such as temperature, pH, electrical conductivity (EC), total dissolved solids (TDS), alkalinity, dissolved oxygen (DO), total hardness (TH), chloride, calcium (Ca), magnesium (Mg), biochemical oxygen demand (BOD), and fluoride. All the parameters were found below the standard limits of Bureau of Indian Standard (BIS, 2012) except total hardness (328.1mg/l to 346.6mg/l), calcium (105.3mg/l to 122.6mg/l), magnesium (46.1mg/l to 55.7mg/l) and fluoride (4.8 to 4.9mg/l). Fluoride was observed more than 3 times than the standard permissible limit (1.5mg/l). Water quality index (WQI) was also applied on the obtained data to make it easy to understand. Based on WQI (including the fluoride), all the four sites fall in unfit for drinking category (250.79, 258.78, 281.78, 247.30) and in poor to very poor category (80.23, 88.19, 88.59, 64.60) excluding the fluoride from WQI calculation. Both the values of WQI shows that fluoride alone is not responsible for the degraded quality of water but other high concentration of salts is also responsible.