Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Meditation, Race, and Anxiety on Stroke Survivor Resilience

Supplemental digital content is available in the text. ABSTRACT BACKGROUND: Significant gaps exist in the identification and management of psychological effects of stroke on survivors. Interventions to enhance resilience, the ability to rebound from stress or adversity, could positively impact stroke recovery. The purpose of this study was to test the effect of meditation on resilience of community-dwelling stroke survivors and to identify resilience predictor variables in these survivors. METHODS: This was a substudy with secondary analysis of existing data from the parent study, MEditatioN for post stroke Depression. The effect of meditation on stroke survivor resilience in the intervention group (n = 20) was evaluated with a paired samples t test, with measures at baseline and immediately after the 4-week intervention. Baseline resilience predictor variables for all stroke survivors (n = 35) were evaluated with univariable analysis and multiple linear regression modeling. RESULTS: The increase in stroke survivor resilience scores from baseline (mean [SD], 3.46 [0.81]) to intervention completion (mean [SD], 3.58 [1.02]) was not statistically significant (t = 0.60, df = 19, P = .56). One-way analysis of variance with Tukey post hoc analysis revealed that baseline resilience was significantly lower (P = .02) for non-Hispanic black participants than for non-Hispanic white participants. Multiple linear regression with resilience as the dependent variable, race as a fixed factor, and trait anxiety as a covariate was significant (F3,33 = 6.32, P = .002) and accounted for nearly 33% of the variance in baseline resilience. CONCLUSION: The effects of meditation on stroke survivor resilience should be tested in larger clinical trials that would explore the influence of social determinants of health, perceived stress, race-related stress, and anxiety subtypes on resilience.
Down‐regulated lncRNA AGAP2‐AS1 contributes to pre‐eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype

Recently, growing evidence has shown that aberrant long non‐coding RNA (lncRNA) expression in conjunction with an impaired trophoblastic phenotype could implicate the pathological process of pre‐eclampsia (PE). However, only a small portion of lncRNAs has been characterized with regard to the function and molecular mechanisms involved in PE. There are still gaps in the available knowledge; as a result, there are currently only a few applicable treatments for PE in the context of lncRNA. Here, we found that lncRNA AGAP2‐AS1 is abnormally down‐regulated in severe PE placenta tissues. Using human trophoblasts, we established that AGAP2‐AS1 knockdown could inhibit trophoblasts proliferation and invasion and promote cell apoptosis. Further, we showed that overexpression of AGAP2‐AS1 substantially stimulated the development of the trophoblastic phenotype. Through high‐throughput sequencing analysis, we demonstrated that silencing of AGAP2‐AS1 favourably regulated various genes which are relevant to trophoblastic growth and invasion. Mechanistically, AGAP2‐AS1 promoted the suppressor protein, Jun dimerization protein 2 (JDP2), by sponging miR‐574‐5p. Resultantly, further impairment of the trophoblastic phenotype was achieved by way of inhibiting cell growth, apoptosis and invasion. We also determined that the expression of AGAP2‐AS1 could be mediated by FOXP1. Our results showed that the down‐regulated expression of lncRNA AGAP2‐AS1 might serve as a key suppressor in PE via inhibition of JDP2 at the post‐transcriptional level by competing for miR‐574; thus, this presents a novel therapeutic strategy for PE.
Varying the Order of Combinations of Single- and Multi-Joint Exercises Differentially Affects Resistance Training Adaptations.

Brandão, L, de Salles Painelli, V, Lasevicius, T, Silva-Batista, C, Brendon, H, Schoenfeld, BJ, Aihara, AY, Cardoso, FN, de Almeida Peres, B, and Teixeira, EL. Varying the order of combinations of single- and multi-joint exercises differentially affects resistance training adaptations. J Strength Cond Res XX(X): 000-000, 2020-Our study aimed to compare the effects of multi-joint (MJ) and single-joint (SJ) exercises, either isolated or in combination, and in different orders, on cross-sectional area (CSA) of the pectoralis major (PM) and different heads of the triceps brachii (TB), as well as on the one-repetition maximum (1-RM) in the bench press and lying barbell triceps press. Forty-three young men were randomly assigned to one of 4 possible RT protocols: barbell bench press plus lying barbell triceps press (MJ + SJ, n = 12); lying barbell triceps press plus barbell bench press (SJ + MJ, n = 10); barbell bench press (MJ, n = 10); or lying barbell triceps press (SJ, n = 11). Results showed significant within-group increases in 1-RM bench press for MJ, MJ + SJ, and SJ + MJ but not for SJ. Conversely, significantly greater within-group increases in elbow extension 1-RM were noted for SJ, MJ + SJ, and SJ + MJ but not for MJ. Significantly greater increases in PM CSA were observed for MJ, MJ + SJ, and SJ + MJ compared with SJ. Significant increases in TB CSA were noted for SJ, MJ + SJ, and SJ + MJ, but not for MJ, without observed between-group differences. Individual analysis of TB heads showed significantly greater CSA increases in the lateral head for MJ, MJ + SJ, and SJ + MJ compared with SJ. Alternatively, significantly greater increases in the long head were observed for SJ, MJ + SJ, and SJ + MJ compared with MJ. CSA increases for the medial head were statistically similar between conditions. Our findings indicate that muscular adaptations are differentially affected by performance of MJ and SJ exercises.
Salvage APR for anal squamous cell carcinoma: Utilization, risk factors and outcomes in a Canadian Population.

BACKGROUND Previous studies have reported that 30-40% of patients with squamous cell carcinoma of the anus will require salvage abdominoperineal resection following chemoradiotherapy. OBJECTIVE To identify the utilization, risk factors and impact on survival of salvage abdominal perineal resection for squamous cell carcinoma of the anus. DESIGN Retrospective, population-based cohort study. PATIENTS All incident cases of squamous cell anal cancer who underwent curative intent radiotherapy from 2007-2015. SETTING Patients treated in Ontario, Canada, a single payer universal health care system. MAIN OUTCOME MEASURES Risk of salvage abdominoperineal resection, factors associated with salvage abdominoperineal resection and survival. RESULTS A total of 1125 patients were treated with curative intent radiotherapy for squamous cell cancer of the anus. Within this cohort, salvage surgery was performed in 8% (93/1125), while 14% (156/1125) required a permanent colostomy. In log-binomial regression, younger age was associated with salvage surgery, while sex, cancer stage, socioeconomic status and HIV were not. There was a suggested lower risk of salvage surgery in those who completed chemoradiation (RR 0.67, 95%CI 0.43 - 1.03). Crude 5-year overall survival rate was 73% (95% CI: 70 - 76%) in those not requiring salvage surgery and 48% (95% CI: 37 - 58%) in those that did. In Cox models mortality was higher in patients requiring salvage surgery compared to those who did not (adjusted HR 2.20, 95%CI: 1.65 - 2.94), while improved survival was seen in those who completed chemoradiation (HR 0.65, 95%CI 0.42 - 0.82) LIMITATIONS:: Potential residual confounding by indication for salvage surgery. CONCLUSIONS In this large, contemporary cohort of patients with squamous cell carcinoma of the anus, the proportion of patients undergoing salvage surgery was considerably lower than previous reports. Younger age was associated with salvage surgery, and there was a suggestion of lower risk of salvage surgery with completion of chemoradiation. Patients requiring salvage surgery had poor 5-year overall survival. See Video Abstract at http://links.lww. com/DCR/B205.
152-164 Kaewpitoon SJ.pmd

This study aimed to determine the prevalence and intensity of intestinal helminth infections (IHIs) among rural villagers in Waeng Noi district, Khon Kaen Province, northeastern Thailand. A cross-sectional study was conducted between March 1 and July 30, 2018, among rural villagers from 30 rural villages in 2 subdistricts. The participants were selected from the village enrollment list after proportional allocation of the total sample size. The background characteristic data were collected using a structured questionnaire. Specimens from patients with IHIs were prepared by concentration with a Faecal Parasite Concentrator–Solvent-Free (Mini Parasep® SF), and helminths were then detected using a light microscope. Of the 400 faecal specimens examined, 23 were positive for at least one intestinal helminth, resulting in a prevalence of 5.75%. The most prevalent helminths were Taenia spp. , 10 (2.50%); followed by hookworm, 5 (1.25%); Trichuris trichiura, 4 (1.0%); Ascaris lumbricoides, 3(0.50%); and Opisthorchis viverrini, 1 (0.25%). All infected participants had a light intensity of IHI. Location (adjusted OR=2.52; 95% CI=1.30–3.52; P =0.042) showed a significant association with the prevalence of intestinal helminths. This study reveals that IHIs, particularly those with foodborne and soil-transmitted species of helminths, are prevalent in adults in rural subdistricts. A greater focus on interventions to improve personal hygiene and sanitation to prevent the spread of IHIs is required. Further studies should be performed to implement interdisciplinary research approaches in the study area.
EFFECT OF ELECTRON-PHONON INTERACTION ON ELECTRON SPIN POLARIZATION IN A QUANTUM DOT LIGHT

This paper presents a theoretical model for the effect of electron-phonon interaction, temperature and magnetic field on degree of electron spin polarization in GaAs/InAs quantum dot LED. To describe the dynamics, quantum Langevin equation for photon number and carrier number is used. Simulation results show that degree of electron spin polarization in quantum dot decreases with increase of electron phonon interaction parameter at constant temperature and constant magnetic field which agrees with experimental results in literatures.
A finite element approximation to elliptic control problems in the presence of control and state constraints

We consider an elliptic optimal control problem with control and pointwise state constraints. The cost functional is approximated by a sequence of functionals which are obtained by discretizing the state equation with the help of linear finite elements and enforcing the state constraints in the nodes of the triangulation. The control variable is not discretized. Error bounds for control and state are obtained both in two and three space dimensions. Finally, we discuss some implementation issues of a generalized Newton method applied to the numerical solution of the problem class under consideration. Mathematics Subject Classification (2000): 49J20, 49K20, 35B37
Evaluation of the Effect of Flowable Composite, Vitremer and Biodentine as intraorifice Barriers on the Fracture Resistance and Coronal Microleakage of Roots Obturated with Gutta Percha – an in Vitro Study

Introduction: Studies show that even in cases where root canal filling is done under good microbial control, recontamination of the root canal system can still occur within days after obturation in teeth without adequate coronal seal. The objective of this in vitro study was to evaluate the effect of flowable composite, Vitremer and Biodentine as intraorifice barriers on the fracture resistance and coronal microleakage of roots obturated with gutta percha. Material and Methods: Crowns of 90 extracted human mandibular premolar teeth were sectioned off to obtain 14mm long root specimens. After endodontic therapy, all samples were then randomly divided into following two main experimental groups: Group 1: fracture resistance test [n=40] Group 2: dye penetration test for coronal microleakage [n=50]. In both experimental groups, the specimens were further sub grouped with respect to the intra orifice barrier material placed after removal of 3mm of the coronal portion of the root fillings: 1) Flowable composite, 2) Vitremer and 3) Biodentine. The specimens in the fracture resistance group were loaded vertically using a universal testing machine at 1mm/min crosshead speed until the fracture occurred. The specimens in the dye penetration group were immersed in Indian ink for 5 days following which they were decalcified, dehydrated and cleared. Microleakage into the canals was measured in millimeters using a stereomicroscope. The results were evaluated statistically using one way ANOVA for multiple comparisons followed by post hoc Tukey test for pairwise comparison. Results: The use of Flowable composite, Vitremer and Biodentine as an intra orifice barrier significantly increased the fracture resistance and decreased the coronal microleakge of the root canal treated teeth. Conclusion: Within the limitations of this study it can be concluded that the use of Flowable composite, Vitremer and Biodentine as an intra orifice barrier after root canal treatment significantly improves the fracture resistance and decreases the coronal microleakge after endodontic therapy.
IMPACT OF THE GESTATION AND MODE OF BIRTH IN THE SYNERGY AMONG TRANSVERSUS ABDOMINIS/INTERNAL OBLIQUE MUSCLES AND PELVIC FLOOR: ELECTROMYOGRAPHIC EVALUATION.

Hypothesis / aims of study Pelvic floor muscle training (PFMT) and abdominal muscles exercises should be carefuly evaluated and coached in order to improve their overall quality and results. So, it is of great importance to understand the synergy of the abdominal-pelvic area in different conditions, such as during pregnancy and puerperium, since during in those phases significant alterations of the abdominal and pelvic floor muscles happen, requiring specific attention and strategies during its supervision, for a real efficacy. The objective of this observational study is to evaluate the electromyographic patterns of the transversus abdominis, obliquous internus and pelvic floor muscles simultaneously, during a protocol of exercises applied to a cohort of women in pregnancy and puerperium, in order to verify which conditions can alter their synergic contraction.
Analysis of the effects of visibility and warning devices on driver injury severity at highway-rail grade crossings considering temporal transferability of data

Abstract This study explores the joint effect of visibility and warning devices on driver injury severity at the highway-rail grade crossings (HRGCs), while also considering other contributing factors. For this purpose, four mixed logit models are developed to estimate the determinants of driver injury severity considering the combinations of visibility conditions (daylight vs. no daylight) and type of warning devices (active vs. passive warning). The models were calibrated using the data obtained from the USDOT Federal Railroad Administration for HRGC crashes that occurred over a ten-year period 2008–2017 across the United States. A temporal transferability test was conducted and confirmed the stability of model specifications considering a ten-year span of collected data. The pseudo-elasticity analysis was conducted to ascertain marginal impact of the contributing factors on driver injury severity in each model. While the vehicle speed, train speed, time of day and driver age are found to be common significant factors among the four models, there are marked differences between parameters associated with various crash factors. The study provides new insight into the driver injury severity in train-vehicle collisions considering visibility and type of warning devices, which can help in setting up proper policies to improve safety at HRGCs.
Reproductive performance of multiparous rabbit lactating does: effect of lighting programs and PMSG use

This study aims to determine if Pregnant Mare Serum Gonadotrophin (PMSG), used for oestrous synchronization in multiparous lactating does, could be replaced by one of the following lighting schedules without impairing reproductive performance: (a) 12-h L (light)/12-h D (dark) or (b) 8-h L/16-h D, until day 6 before artificial insemination (AI), when in both cases photoperiod was changed to 16-h L/8-h D and maintained until the day of AI, and in the following 4 days post AI the light hours were progressively reduced to the initial schedules. Two groups of 20 does each were respectively submitted to one of the lighting schedules specified above. All does were artificially inseminated in 6 consecutive cycles at 42 days intervals. In the first, third and fifth AIs, PMSG (20 IU/ doe via sc 48 h before AI) was used in the two groups of does, whereas in the second, fourth and sixth AIs no hormonal treatment was used. Degree of oestrous synchronization (also referred in text as sexual receptivity) was estimated by the colour of the vulva at AI. Reproductive performance of does was evaluated based on fertility (kindling rates), prolificity, mortality at birth, mortality at 21 days post birth, weight of the litter at 21 days post birth and number of weaned rabbits. Oestrous was better synchronized when PMSG was used with any of the two lighting programs. Without using PMSG, a photoperiod of 12-h L/12-h D until 6 days before AI resulted in a better sexual receptivity of does than 8-h L/16-h D. Fertility, prolificity, mortality of young rabbits at 21 days, the weight of the litters at 21 days and the number of weaned rabbits did not vary with the lighting program and were not affected by the PMSG treatment. Mortality at birth, however, was higher (+1 dead kit per litter) in litters housed under a light program of 12-h L/12-h D. Global productivity (number of weaned rabbits per 100 inseminated does) was better when using PMSG, for both lighting schedules. When using a Reprod. Nutr. Dev. 41 (2001) 247–257 247 © INRA, EDP Sciences, 2001 * Correspondence and reprints E-mail: laquiari@correo.lugo. usc.es L. Quintela et al. 248
WikiTalk corpus: a resource for deﬁning ”online discussion” genre

Wikipedia constitutes a popular and extremely useful resource for studies in both linguistics and natural language processing (see [Yano and Kang 2008]). This paper introduced a new language resource based on the French Wikipedia online discussion pages, the WikiTalk corpus. The corpus includes 159,578,279 words and 3,022,240 posts structured into 1,024,351 thematic sections and has automatic syntactic analyses produced with the Talismane analyser ([Urieli 2013]), and is made publicy available. In this paper, we present the diﬀerent steps of construction process and a linguistic analysis on the discussions and on the language used in them.
Hamburger Beitr¨age zur Angewandten Mathematik Logarithmic growth of temporal and spatial complexity in single and double reversals

In the present paper memory e(cid:14)cient implementation of evolutions consisting of two and three alternative sweeps are considered. Two-sweeps evolutions result for instance by a reversal of a program execution needed in automatic di(cid:11)erentiation. Three-sweeps evolutions arise through the solution of optimal control problems by Newton’s method or through the spatial discretization of PDEs with adaptive FE grids. The memory e(cid:14)cient implementation of various types of two sweeps evolutions with checkpointing techniques was already discussed in the literature. Nevertheless, in the present paper we introduce and prove new representation for the minimal temporal complexity of single reversals. This new representation gives so far unknown properties of optimal checkpointing strategies and thus provides new insights. After that, we extend the so far known results concerning the logarithmic complexity of single reversal to the double reversal case. In this context we prove in the present paper that the temporal complexity needed to implement a triple-sweep evolution grows as a second power of natural logarithm of a number of time steps representing a sweep length.
Cognitive Workload Analysis of Fighter Aircraft Pilots in Flight Simulator Environment

Maintaining and balancing an optimal level of workload is essential for completing the task productively. Fighter aircraft is one such example, where the pilot is loaded heavily both physically (due to G manoeuvering) and cognitively (handling multiple sensors, perceiving, processing and multi-tasking including communications and handling weapons) to fulfill the combat mission requirements. This cognitive demand needs to be analysed to understand the workload of fighter pilot. Objective of this study is to analyse dynamic workload of fighter pilots in a realistic high-fidelity flight simulator environment during different flying workload conditions. The various workload conditions are (a) normal visibility, (b) low visibility, (c) normal visibility with secondary task, and (d) low visibility with secondary task. Though, pilot’s flying performance score was good, the physiological measure like heart rate variability (HRV) features and subjective assessment (NASA-TLX) components are found to be statistically significant (p<0.05) between tasks. HRV features such as SD2, SDNN, VLF and total power are found to be significant at all task load conditions. The features LFnu and HFnu are able to differentiate the effect of low visibility and secondary cognitive task, which was imposed as increased task in this study. This result benefits to understand the pilot’s task and performance at each flying phase and their cognitive demands during dynamic workload using HRV, which could assist pilot’s training schedule in optimal way on simulators as well as in actual flight conditions.
Modeling of the subgrid scale wrinkling factor for large-eddy simulation of turbulent premixed combustion

We propose a model for assessing the unresolved wrinkling factor in LES of turbulent premixed combustion. It relies essentially on a power-law dependence of the wrinkling factor to the filter size and an original expression for the ’active’ corrugating strain rate. The latter is written as a product of an efficiency function which accounts for viscous effects and the kinematic constraint of Peters, by a recent expression for the turbulent strain intensity. Yields functional expressions for the fractal dimension and the inner cut-off length scale, the latter being (i) filter-size independent and (ii) consistent with the Damköhler asymptotic behaviours at both large and small Karlovitz numbers. A new expression for the wrinkling factor which incorporates finite Reynolds numbers effects is further proposed. Finally, the model is successfully assessed on an experimental filtered database.
FUNCTIONALLY GRADED ALUMINIUM ALLOYS

The paper analyses the fundamentals of processing functionally graded alloys and presents the experimental results obtained by static and centrifugal casting of Al-Si, Al-Cu and Al-Zn alloys in a a centrifugally cast tube part with a length of 80 mm and outer diameter 80.The significant difference between the structures of the outer and inner layers is highlighted also by the summary quantitative analysis of the proportion of constituents in case alloys: AlCu10 , Al55Zn43Si2.