Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Company Performance on Stock Returns in the LQ45 Stock Cluster in 2020-2022

In the Indonesian capital market, various securities are traded, but stock investors dominate. The LQ45 index illustrates the Indonesian capital market condition is better than the JCI (Jakarta Composite Index). Stocks on the LQ45 index have large market capitalization, high liquidity, and good company fundamentals, but have varying returns. It is necessary to group the stock returns of LQ45 index companies. The method used is time series clustering in the 2020-2022 period. Furthermore, the logistic regression analysis is used to determine the effect of company performance that is consistent in the LQ45 index on stock return status. The results showed that the selected algorithm for clustering was K-Means with 2 optimal numbers of clusters characterized as lagging stock and leading stock. Then, company stocks in the LQ45 index for the 2020-2022 period tend to be classified as leading stocks if they have a low Debt to Equity Ratio but have a high Net Profit Margin and Price Earnings Ratio.
Screening of Lactiplantibacillus plantarum NML21 and Its Maintenance on Postharvest Quality of Agaricus bisporus through Anti-Browning and Mitigation of Oxidative Damage

Browning and other undesirable effects on Agaricus bisporus (A. bisporus) during storage seriously affect its commercial value. In this study, a strain, Lactiplantibacillus plantarum NML21, that resists browning and delays the deterioration of A. bisporus was screened among 72 strains of lactic acid bacteria (LAB), and its preservative effect was analyzed. The results demonstrated that gallic acid, catechin, and protocatechuic acid promoted the growth of NML21, and the strain conversion rates of gallic acid and protocatechuic acid reached 97.16% and 95.85%, respectively. During a 15 d storage of the samples, the NML21 treatment displayed a reduction in the browning index (58.4), weight loss (2.64%), respiration rate (325.45 mg kg−1 h−1), and firmness (0.65 N). The treatment further inhibited Pseudomonas spp. growth and polyphenol oxidase activity, improved the antioxidant capacity, reduced the accumulation of reactive oxygen species, and reduced the malonaldehyde content and cell membrane conductivity. Taken together, the optimized concentrations of NML21 may extend the shelf life of A. bisporus for 3–6 d and could be a useful technique for preserving fresh produce.
Influence of hepcidin on iron homeostasis during last trimester of gestation in Bos indicus (cattle)

Hepcidin is an important hormone regulating the systemic iron bio-availability. Blood samples were collected from thirty pregnant cattle during their last trimester of pregnancy to assess the relation of hepcidin to iron homeostasis. Serum hepcidin level was quantified using ELISA and serum iron, transferrin iron binding capacity and unsaturated iron binding capacity were estimated by colorimetric method. Correlation between hepcidin and other iron related parameters was assessed. Dependency of serum iron level on hepcidin was also determined by regression method. It was revealed that hepcidin was negatively correlated to serum iron and transferrin iron binding capacity (p less than 0.001) and also hepcidin has highest predictive value on serum iron level and transferrin iron binding capacity (p less than 0.001). It can be concluded that during pregnancy increase in hepcidin reduces the maternal serum iron and also it is a biomarker for iron bioavailability to the developing fetus.
Effect of broiler chickens living conditions on results of fattening.

This work was aimed to monitor outdoor temperature, air humidity and internal microclimate conditions in broilers house during summer days, the temperature and the quality of bedding material as well as bird density. To evaluate the quality of litter we set three-tier system. If the litter dry and hard value was ‘1’ if it was moist and supple value was ‘2’, and if it was wet – value was ‘3’. The measurements were carried out on the 10 and 20 days of chickens age. Air temperature was monitored by (logger Comet R 3120) thermometer and for the measurement of the litter temperature used a non-contact thermometer (Raytek Raynger ST). To find out the birds density a thermocamera (Guide TP8S) for thermal imaging was used and subsequent shots are evaluated the birds stocking density. If the bird density high, value was ‘1’, if the bird density median, value was ‘2’ and if the density low, value was ‘3’. The hall was divided into 33 rectangular shapes. Results showed that the bedding quality averageed 1.2 on day 10 and 1.3 on day 20 of fattening (dry and hard). By comparing the P values and the significance level α (0.05), the value of 0.651 and 0.820 was found respectively for both age. No significance was detected between the litter temperature and the litter quality, also between bedding temperature and birds density. Intercomparison for bedding temperature and quality on days 10 and 20 a significant difference (0.000 < 0.05) was observed.
Comparatives, Superlatives and Definiteness in Romance

Romance languages do not have superlative-dedicated morphemes (see most/-est in English) but instead express superlative meanings by using a comparative combined with a definite article. There are, however, interesting crosslinguistic differences that indicate that the role of “definiteness” for the superlative meaning of comparatives is different across Romance languages. Thus, French superlative adverbs and superlative postnominal adjectives are necessarily formed with (what looks like) a definite article (THE notates items that are morphologically identical to the definite article across languages) preceding the comparative morpheme plus (ER notates the comparative morpheme across languages, regardless of whether it is an affix or a free standing morpheme), whereas in the Italian corresponding examples THE is banned. According to Loccioni (2018) this crosslinguistic difference is not structural: in order to get superlative meanings Italian comparatives would be formed with a covert D(eterminer) corresponding to THE in French. I will propose instead that whereas French has a superlative-dedicated phrase of the form [THE ER], Italian has a “bare”, i.e., a THE-less ER that moreover lacks a than-argument, which gets a superlative meaning via raising to the Spec of [D°THE].
Integrated Metaphorming Learning Model of 21st Century Skills to Increase Student Creativity

Based on PISA research, current learning has yet to be able to develop student creativity. Creativity is an ability that reflects fluency, flexibility in thinking, and the ability to develop, enrich, and detail quality ideas to solve problems. This research was conducted to analyze the increase in student creativity through an integrated Metaphorming learning model for 21st century skills. This research used a quantitative approach, a quasi-experimental type, and a Nonequivalent Control Group Design. The data collection method uses tests. The data collection instrument uses test questions. The sample was 30 students from Unit D as the control class and Unit E with 32 students as the experimental class who were selected using purposive sampling. The data analysis technique uses gain index calculations (N-Gain). The research results show that the Metaphorming learning model integrated with 21st century skills can increase student creativity. However, learning outcomes are similar between students taught with the integrated Metaphorming learning model of the 21st century and with the integration of 21st-century skills. Hypothesis testing shows that Creativity only influences a 25% increase in student learning outcomes; the rest is influenced by factors not measured in this research. It was concluded that the Metaphorming learning model integrated with 21st century skills positively impacted student creativity.
Implementation of AI in Traffic Management: Need, Current Techniques and Challenges

In the most recent years, technology, including Artificial Intelligence (AI) has advanced in every industry conceivable. Artificial Intelligence has been a keen area of interest in solving everyday problems that humans face. One such area of application is Traffic Management, which required extensive human involvement since the beginning, but now researchers from all over the world are working to introduce the use of Artificial Intelligence in managing the road traffic in the major cities to eliminate the issue of traffic congestion. Artificial Intelligence (AI) has emerged as a promising solution for addressing the persistent challenges associated with traffic management in major cities. Several attempts have been made in this regard and different techniques are being worked upon till date, but the world is still far from observing the widespread use of AI in major cities. This paper presents an analysis on why Artificial Intelligence is needed for traffic management, what techniques have been developed so far and what are the common challenges that are hindering the widespread application of AI in traffic management.
Telomere dysfunction drives pulmonary fibrosis and offers new therapeutic strategies

Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2-3 years. Loss of alveolar type II (ATII) cells and impairment of the regenerative capacity of the lung are also characteristic of the disease. Mutations in components of the telomere-maintenance enzyme telomerase or in proteins important for telomere protection are found both in familiar and sporadic IPF cases. Critically short or dysfunctional telomeres can impair tissue regeneration and have been established as a risk factor to develop IPF. New therapeutic targets and treatments are necessary; however, the lack of mouse models that faithfully recapitulate the human disease has hampered new advances. Here, we generated two independent mouse models, which develop IPF owing to telomere dysfunction. Severe telomere dysfunction in the absence of telomere shortening was induced by Trf1 deletion in ATII cells leading to pulmonary fibrosis. Mice deficient for telomerase presenting critically short telomeres were treated with low dosage of bleomycin to induce IPF. Bleomycin inoculation synergized with short telomeres provoking fibrosis in the lungs. We show that both mouse models develop pulmonary fibrosis through induction of telomere damage. Loss of lung function owing to replacement of lung cell types by fibrotic and inflammatory infiltrates was observed in both mouse models. In conclusion, those mouse models provide proof of principle of the causal role of DNA damage stemming from dysfunctional telomeres in IPF development and identifying telomeres as promising targets for new treatments. The mouse model of pulmonary fibrosis owing to short telomeres generated (Tertdeficient mice subjected to a low bleomycin dose) was used to test the therapeutic efficacy of telomerase activation using AAV9 virus carrying the telomerase Tert gene. We find that AAV9-Tert preferentially targets ATII cells. AAV9-Tert treatment following radiological diagnosis of pulmonary fibrosis resulted in significant reversal of fibrosis and full remission in 50% of the mice 7 weeks after diagnosis, while all the mice treated with the empty vector still showed severe fibrosis. Reversal of fibrosis in AAV9-Tert treated mice was associated with an increase in telomere length in ATII cells, decreased DNA damage, and decreased apoptosis and senescence. AAV9-Tert treatment increased the percentage of proliferating ATII cells and lead to gene expression changes indicative of decreased fibrosis and increased regeneration. These results obtained during this Thesis indicate that telomerase gene therapy is effective in the treatment of pulmonary fibrosis provoked or associated with short telomeres.
Experimental and numerical investigation of backward erosion piping in heterogeneous sands

Backward erosion piping is a relevant failure mechanism for water–retaining structures that determines uncertainty in residual flooding hazard and risk mapping. The occurrence of piping can be predicted using the Sellmeijer model, which is developed and validated for homogeneous granular layers. However, the subsurface encountered below levees can be far from homogeneous. Previous laboratory tests indicated a substantial increase of piping resistance in sand samples with variation of properties in the path of the pipe. In the research described in this paper the process of backward erosion piping in heterogeneous sands was investigated by means of small–scale experiments to study the influence of micro–scale and macro–scale heterogeneity. Numerical simulations of piping experiments with macro–scale heterogeneity were performed using a 2D groundwater flow model extended with a piping module and a 3D groundwater flow model.
Large and Mainly Unnoticed: The First Lower Tithonian Record of a Suspension-Feeding Pachycormid from Southern Gondwana

Abstract. A large fossil specimen could easily go unnoticed, especially when the specimen osteology is not well known, is usually represented by fragmentary material and has a sparsely ossified skeleton resulting in low preservation potential. This is particularly true for the suspensionfeeding Pachycormiformes, a clade of actinopterygians. This work provides the description of a complete gill raker recovered from the Upper Jurassic (lower Tithonian) levels of the Vaca Muerta Formation at Cerro Lotena, Neuquén Province, southwestern Argentina. The specimen is referred to the suspension-feeding pachycormid, Leedsichthys, based on similarities in size and shape morphology of the gill raker stalk, the shape of the gill raker base and for having similar morphology of the fimbriae (growing tongue-like distally). Although suspension-feeding pachycormids are known mainly from Laurasia, some remains were also recovered from Gondwana. The lower Tithonian Leedsichthys record extends the geographic and stratigraphic range of the suspension-feeding clade and that of the genus Leedsichthys.
Brazilian Journal of Microbiology (2012):

The role of rhinovirus asymptomatic infections in the transmission among close contacts subjects is unknown. We tested health care workers, a pair of one child and a family member and immunocompromised patients (n =191). HRV were detected on 22.9% symptomatic and 3.6% asymptomatic cases suggesting lower transmission among contacts.
Apatinib combined with camrelizumab in the treatment of recurrent/metastatic nasopharyngeal carcinoma: a prospective multicenter phase II study

Background Preclinical studies demonstrated that immune checkpoint inhibitors combined with antiangiogenic drugs have a synergistic anti-tumor effect. This present phase II trial aimed to evaluate the efficacy and safety of apatinib combined with camrelizumab in patients with recurrent/metastatic nasopharyngeal carcinoma (RM-NPC). Methods Patients with RM-NPC were administered with apatinib at 250 mg orally once every day and with camrelizumab at 200 mg via intravenous infusion every 2 weeks until the disease progressed or toxicity became unacceptable. The objective response rate (ORR) was the primary endpoint, assessed using RECIST version 1.1. Progression-free survival (PFS), overall survival (OS), disease control rate (DCR) and safety were the key secondary endpoints. This study was registered with ClinicalTrials.gov, NCT04350190. Results This study enrolled 26 patients with RM-NPC between January 14, 2021 and September 15, 2021. At data cutoff (March 31, 2023), the median duration of follow-up was 16 months (ranging from 1 to 26 months). The ORR was 38.5% (10/26), the disease control rate (DCR) was 61.5% (16/26), and the median PFS was 6 months (IQR 3.0-20.0). The median OS was 14 months (IQR 6.0-21.25). Treatment-related grade 3 or 4 adverse events occurred in seven (26.9%) patients, and comprised anemia (7.7%), stomatitis (3.8%), headache (3.8%), pneumonia (7.7%), and myocarditis (3.8%). There were no serious treatment-related adverse events or treatment-related deaths. Conclusion In patients with RM-NPC, apatinib plus camrelizumab showed promising antitumor activity and manageable toxicities.
Asymmetries in the Stem and Suffix Masked Priming Response in a Large-scale Online Study

Models of visual word processing incorporate morphological decomposition as a step in the recognition process, but they vary as to when this step happens, and what kind of information is used in it. In particular, the affix stripping model proposes that words are accessed through their stems, after affixes are automatically stripped off. This dichotomy between stems and affixes seems to be mirrored in masked priming. Masked stem priming is quite robust and comparable to masked repetition priming, whereas masked affix priming is often null, or very small. However, the literature on masked affix priming is much smaller than the one on masked stem priming. This study investigates the stem vs suffix asymmetry in masked priming by running an online experiment with a large sample size (N=161) to ensure higher statistical power. For comparison and validation, the same experiment was also conducted in a standard lab setting. In addition, we ran a follow-up experiment with two additional suffix priming conditions with an even larger sample size (N=400) to assess the influence of orthographic and strategic confounds. The three experiments show significant stem priming, but null or very small suffix priming, thus supporting the asymmetry between stem activation and affix stripping.
Probabilistic Seismic Performance Assessment of Tall RC Special Moment-resisting Frame Buildings Equipped with Buckling-restrained Braces under Near-field Excitations

Many tall buildings have already been constructed near faults throughout the world, several of which have sustained casualties and economic losses during strong ground motions. This study investigates the effect of near-fault excitations on the vulnerability of tall, reinforced concrete (RC) special moment-resisting frame (SMRF) buildings equipped with buckling-restrained braces (BRBs) using seismic fragility curves. After attaining the structure’s response modification factor (R), three-dimensional (3D) models of 15-, 25- and 35-story frames were developed by the OpenSees software according to the Iranian code provisions. Thus, the seismic response of the elements was obtained. Subsequently, incremental dynamic analysis (IDA) was conducted by selecting a suitable number of compatible accelerograms in two near-field and far-field groups. Considering the maximum story drift as the demand parameter and selecting the interstory drift ratios (IDR) for the slight, moderate, extensive, and complete collapse seismic performance levels proposed by Hazus, IDA curves were plotted. Then, the seismic fragility curves were produced using the structural reliability relations. The median fragility at complete collapse damage level reduced from 0.73g, 0.62g, and 0.61g to 0.68g, 0.59, and 0.57g for the 15-, 25, and 35-story near-field and far-field earthquake models, respectively. This was attributed to increasing vulnerability and seismic fragility of the structures as a result of both height increase and distance reduction from fault. Based on the results, the most vulnerable structure, i.e., the 35-story near-fault model, experienced a 40, 17, 18, and 6% increase in median fragility at slight, moderate, extensive, and complete collapse damage levels, respectively.
Drug-related problems identified by clinical pharmacists in an academic medical centre in Thailand

ABSTRACT Background: Drug-related problems (DRPs) are important issues that interfere with therapeutic outcomes and can cause adverse events. Pharmacists play a vital role in identifying and resolving DRPs. This study aimed to determine the characteristics, and severity of DPRs, including clinical pharmacists’ interventions. Method: A retrospective study was conducted at Ramathibodi Hospital, a tertiary university hospital in Thailand. We collected data from the drug-related problem system and the electronic medical record. Descriptive statistics were performed with Statistical Package for Social Sciences (SPSS) software version 18.0. Results: There were 580 patients (20.44%) who had at least one DRP. We classified 1255 DRPs based on Cipolle-Strand-Morley Criteria 2012. The most common DRPs were the need for additional drug therapy (27.09%), followed by dosage too low (26.93%) and dosage too high (22.31%). Anti-infective agents (23.71%) and omeprazole (2.70%) were the most common drug groups and drugs causing DRPs, respectively. The severity of DRPs was mostly categorised to be ‘no harm' (95.46%). Almost all of the interventions were completely accepted by physicians (99.12%). Conclusion: The most common DRPs were the need for additional drug therapy and dosage adjustment of antimicrobial agents. The clinical pharmacists on wards are effective in preventing and resolving DRPs.
PR-TCAM: Efficient TCAM Emulation on Xilinx FPGAs Using Partial Reconfiguration

Modern field-programmable gate arrays (FPGAs) provide a vast amount of logic resources that can be used to implement complex systems while providing the flexibility to modify the design once deployed. This makes them attractive for software-defined networks (SDNs) applications, and, in fact, most vendors provide the building blocks needed for those applications, which include basic packet classification functions such as exact match, longest prefix match, and match with wildcards. Those are needed for different functions such as routing, security filtering, monitoring or quality of service. The match with wildcards can be done using ternary content addressable memories (TCAMs). TCAMs can be implemented as independent standalone devices or as Internet Protocol (IP) blocks that are used inside networking application-specific integrated circuits (ASICs) such as switching ICs. In both cases, the cells of a TCAM are more complex than that of a normal memory and also than that of a binary content addressable memory (CAMs). This is due to the more complex matching that they need to implement. As FPGAs are used in many different applications, it does not make sense to include TCAM blocks inside them as they would be used only in a small fraction of the systems. Therefore, TCAMs are emulated using the logic resources available inside the FPGA. In recent years, a number of schemes to emulate TCAMs on FPGAs have been proposed, some of them based on the use of the logic resources and others on the use of the embedded memory blocks available on the FPGA. In this brief, a technique to efficiently emulate TCAMs on Xilinx FPGAs is presented. The proposed scheme is based on the use of lookup tables (LUTs) and partial reconfiguration to achieve a more effective use of the FPGA resources while supporting the addition and removal of rules. The proposed scheme has been compared to existing implementations and the results show that it can achieve significant savings in resource usage. In addition, it enables the use of all the LUTs in the device for TCAM implementation, something that is not supported by existing approaches that use LUTRAMs.