Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictors of thrombosis and bleeding in 1613 myelofibrosis patients from the Spanish Registry of Myelofibrosis

Available data have proved insufficient to develop consensus recommendations on the prevention of thrombosis and bleeding in myelofibrosis (MF). We evaluated the incidence and risk factors of vascular complications in 1613 patients from the Spanish Myelofibrosis Registry. Over a total of 6981 patient‐years at risk, 6.4% of the study population had at least one thrombotic event after MF diagnosis, amounting to an incidence rate of 1.65 per 100 patient‐years. Prior history of thrombosis, the JAK2 mutation, and the intermediate‐2/high‐risk International Prognostic Scoring System (IPSS) categories conferred an increased thrombotic risk after adjustment for the risk‐modifying effect of anti‐thrombotic and cytoreductive treatments. History of thrombosis and the JAK2 mutation allowed us to pinpoint a group of patients at higher risk of early thrombosis. No decreased incidence of thrombosis was observed while patients were on anti‐thrombotic or cytoreductive treatment. An increased risk of venous thrombosis was found during treatment with immunomodulatory agents. A total of 5.3% of patients had at least one episode of major bleeding, resulting in an incidence rate of 1.5 events per 100 patient‐years. Patients in the intermediate‐2/high‐risk IPSS categories treated with anti‐coagulants had an almost sevenfold increased risk of major bleeding. These findings should prove useful for guiding decision‐making in clinical practice.
CircSUCO promotes proliferation and differentiation of chicken skeletal muscle satellite cells via sponging miR-15

ABSTRACT 1. In a previous high-throughput sequencing study, a novel circular RNA (circRNA) generated from a SUN domain containing ossification factor (SUCO) gene transcript (circSUCO) was differentially expressed during the embryonic muscle development. This study aimed to further explore the effect of circSUCO on chicken skeletal muscle development. 2. The experiment analysed the expression patterns of circSUCO in Tianfu broilers and clarified its function in the chicken skeletal muscle satellite cells (SMSC) after circSUCO knockdown. The qPCR results showed circSUCO was highly expressed in skeletal muscle and has different expression levels during various development periods. 3. Mechanistically, a series of in vitro experiments showed that circSUCO interference suppressed proliferation and differentiation of SMSC. In addition, it was observed that circSUCO competitively binds with microRNAs such as miR-15a, miR-15b-5p, and miR-15c-5p according to the dual-luciferase assay and qPCR. 4. Correlation was positive between the circSUCO expression level and the ratio of the breast muscle. The results revealed that circSUCO could play a positive role in proliferation and differentiation of SMSC via sponging miR-15a, miR-15b-5p, and miR-15c-5p, hence, may contribute to skeletal muscle development in chicken.
Frailty and emergency surgery: identification and evidence‐based care for vulnerable older adults

Frailty is a multidimensional state related to accumulation of age‐ and disease‐related deficits across multiple domains. Older people represent the fastest growing segment of the peri‐operative population, and 25–50% of older surgical patients live with frailty. When frailty is present before surgery, adjusted rates of morbidity and mortality increase at least two‐fold; the odds of delirium and loss of independence are increased more than four‐ and five‐fold, respectively. Care of the older person with frailty presenting for emergency surgery requires individualised and evidence‐based care given the high‐risk and complex nature of their presentations. Before surgery, frailty should be assessed using a multidimensional frailty instrument (most likely the Clinical Frailty Scale), and all members of the peri‐operative team should be aware of each patient's frailty status. When frailty is present, pre‐operative care should focus on documenting and communicating individualised risk, considering advanced care directives and engaging shared decision‐making when feasible. Shared multidisciplinary care should be initiated. Peri‐operatively, analgesia that avoids polypharmacy should be provided, along with delirium prevention strategies and consideration of postoperative care in a monitored environment. After the acute surgical episode, transition out of hospital requires that adequate support be in place, along with clear discharge instructions, and review of new and existing prescription medications. Advanced care directives should be reviewed or initiated in case of readmission. Overall, substantial knowledge gaps about the optimal peri‐operative care of older people with frailty must be addressed through robust, patient‐oriented research.
From animal studies into clinical trials: the relevance of animal models to develop vaccines and therapies to reduce disease severity and prevent hRSV infection

ABSTRACT Introduction Human respiratory syncytial virus (hRSV) is an important cause of lower respiratory tract infections in the pediatric and the geriatric population worldwide. There is a substantial economic burden resulting from hRSV disease during winter. Although no vaccines have been approved for human use, prophylactic therapies are available for high-risk populations. Choosing the proper animal models to evaluate different vaccine prototypes or pharmacological treatments is essential for developing efficient therapies against hRSV. Areas covered This article describes the relevance of using different animal models to evaluate the effect of antiviral drugs, pharmacological molecules, vaccine prototypes, and antibodies in the protection against hRSV. The animal models covered are rodents, mustelids, bovines, and nonhuman primates. Animals included were chosen based on the available literature and their role in the development of the drugs discussed in this manuscript. Expert opinion Choosing the correct animal model is critical for exploring and testing treatments that could decrease the impact of hRSV in high-risk populations. Mice will continue to be the most used preclinical model to evaluate this. However, researchers must also explore the use of other models such as nonhuman primates, as they are more similar to humans, prior to escalating into clinical trials.
Socially assistive robotics and older family caregivers of young adults with Intellectual and Developmental Disabilities (IDD): A pilot study exploring respite, acceptance, and usefulness

Introduction The need for caregiver respite is well-documented for the care of persons with IDD. Social Assistive Robotics (SAR) offer promise in addressing the need for caregiver respite through ‘complementary caregiving’ activities that promote engagement and learning opportunities for a care recipient (CR) with IDD. This study explored the acceptability and usefulness of a SAR caregiver respite program responsive to feedback from both young adults with IDD and their older family caregivers (age 55+). Method Young adults with IDD and caregiver dyads (N = 11) were recruited. A mixed methods research design was deployed in three phases: Phase I with four focus groups to inform the program design; Phase II for program demonstration and evaluation with pre- and post-surveys; and Phase III with post-program interviews for feedback and suggestions. Results Both young adults with IDD and their caregivers scored favorably the social presence of, social engagement, and satisfaction with robot Pepper. Though there was no significant improvement of caregiving burden/stress as well as well-being of the young adults with IDD based on surveys, results from interviews suggested that the SAR may offer physical/emotional respite to caregivers by providing companionship/friendship as well as promoting independence, safety/monitoring, and interactive engagement with children. Discussion SAR has potential in providing respite for older family caregivers. Future studies need a longer program design and larger sample size to develop a promising intervention and test its feasibility and efficacy.
ISOTROPIC DETECTABLE X-RAY COUNTERPARTS TO GRAVITATIONAL WAVES FROM NEUTRON STAR BINARY MERGERS

Neutron star binary mergers are strong sources of gravitational waves (GWs). Promising electromagnetic counterparts are short gamma-ray bursts (GRBs), but the emission is highly collimated. We propose that the scattering of the long-lasting plateau emission in short GRBs by the merger ejecta produces nearly isotropic emission for ∼ 10 4 ? > s with flux 10 − 13 – 10 − 10 ? > erg cm−2 s−1 at 100 Mpc in X-ray. This is detectable by Swift/XRT and wide field X-ray detectors such as ISS-Lobster, Einstein Probe, eROSITA, and WF-MAXI, which are desired by the infrared and optical follow-ups to localize and measure the distance to the host galaxy. The scattered X-rays obtain linear polarization, which correlates with the jet direction, X-ray luminosity, and GW polarizations. The activity of the plateau emission is also a natural energy source of a macronova (or kilonova) detected in short GRB 130603B without the r-process radioactivity.
Investigating form and content of emotional and non-emotional laughing

Abstract As cold actions (i.e. actions devoid of an emotional content), also emotions are expressed with different vitality forms. For example, when an individual experiences a positive emotion, such as laughing as expression of happiness, this emotion can be conveyed to others by different intensities of face expressions and body postures. In the present study, we investigated whether the observation of emotions, expressed with different vitality forms, activates the same neural structures as those involved in cold action vitality forms processing. To this purpose, we carried out a functional magnetic resonance imaging study in which participants were tested in 2 conditions: emotional and non-emotional laughing both conveying different vitality forms. There are 3 main results. First, the observation of emotional and non-emotional laughing conveying different vitality forms activates the insula. Second, the observation of emotional laughing activates a series of subcortical structures known to be related to emotions. Furthermore, a region of interest analysis carried out in these structures reveals a significant modulation of the blood-oxygen-leveldependent (BOLD) signal during the processing of different vitality forms exclusively in the right amygdala, right anterior thalamus/hypothalamus, and periaqueductal gray. Third, in a subsequent electromyography study, we found a correlation between the zygomatic muscles activity and BOLD signal in the right amygdala only.
Hybridisation and chloroplast capture between distinct Themeda triandra lineages in Australia

Ecotypes are distinct populations within a species that are adapted to specific environmental conditions. Understanding how these ecotypes become established, and how they interact when reunited, is fundamental to elucidating how ecological adaptations are maintained. This study focuses on Themeda triandra, a dominant grassland species across Asia, Africa and Australia. It is the most widespread plant in Australia, where it has distinct ecotypes that are usually restricted to either wetter and cooler coastal regions or the drier and hotter interior. We generate a reference genome for T. triandra and use whole genome sequencing for over 80 Themeda accessions to reconstruct the evolutionary history of T. triandra and related taxa. Organelle phylogenies confirm that Australia was colonized by T. triandra twice, with the division between ecotypes predating their arrival in Australia. The nuclear genome provides evidence of differences in the dominant ploidal level and gene‐flow among the ecotypes. In northern Queensland there appears to be a hybrid zone between ecotypes with admixed nuclear genomes and shared chloroplast haplotypes. Conversely, in the cracking claypans of Western Australia, there is cytonuclear discordance with individuals possessing the coastal chloroplast and interior clade nuclear genome. This chloroplast capture is potentially a result of adaptive introgression, with selection detected in the rpoC2 gene which is associated with water use efficiency. The reason that T. triandra is the most widespread plant in Australia appears to be a result of distinct ecotypic genetic variation and genome duplication, with the importance of each depending on the geographic scale considered.
Intuitive thinking impedes cooperation by decreasing cooperative expectations for pro-self but not for pro-social individuals

ABSTRACT This study conducted two experiments to explore the effects of intuitive thinking and social value orientation (SVO) on cooperative behavior and assess the mediating effect of cooperative expectations. It manipulated intuitive thinking by increasing the participants’ need for cognitive closure, classified SVO using the triple-dominance measure, measured cooperative behavior using the prisoner’s dilemma game, and considered cooperative expectations based on participants’ assessments of the cooperativeness of their counterparts. Both experiments showed that intuitive thinking increased and decreased the cooperation of pro-social and pro-self individuals, respectively. In pro-self individuals, cooperative expectations mediated the effect of intuitive thinking on cooperation.
Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders

Abstract Context The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD). Objective To explore the effective targets of TSD on DD animal models. Materials and methods Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC–MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed. Results Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED50=3.2 g/kg). Antidepressant effects of TSD were associated with 13 decreased metabolites and the restorations of ornithine and urea in the serum. TSD (5 g/kg) raised serum serotonin by 54.1 mg/dL but suppressed arginase I (Arg I) by 47.8 mg/dL in the CUMS rats. Proteins on the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) axis that modulate the inhibition of Arg I were suppressed in the CUMS rats but reversed by the TSD intervention. Discussion and conclusions TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
Searching a High Performance Feature Extractor for Text Recognition Network

Feature extractor plays a critical role in text recognition (TR), but customizing its architecture is relatively less explored due to expensive manual tweaking. In this article, inspired by the success of neural architecture search (NAS), we propose to search for suitable feature extractors. We design a domain-specific search space by exploring principles for having good feature extractors. The space includes a 3D-structured space for the spatial model and a transformed-based space for the sequential model. As the space is huge and complexly structured, no existing NAS algorithms can be applied. We propose a two-stage algorithm to effectively search in the space. In the first stage, we cut the space into several blocks and progressively train each block with the help of an auxiliary head. We introduce the latency constrain into the second stage and search sub-network from the trained supernet via natural gradient descent. In experiments, a series of ablation studies are performed to better understand the designed space, search algorithm, and searched architectures. We also compare the proposed method with various state-of-the-art ones on both hand-written and scene TR tasks. Extensive results show that our approach can achieve better recognition performance with less latency. Code is avaliable at https://github.com/AutoML-Research/TREFE.
Deep Discriminative Feature Models (DDFMs) for Set Based Face Recognition and Distance Metric Learning

This article introduces two methods that find compact deep feature models for approximating images in set based face recognition problems. The proposed method treats each image set as a nonlinear face manifold that is composed of linear components. To find linear components of the face manifold, we first split image sets into subsets containing face images which share similar appearances. Then, our first proposed method approximates each subset by using the center of the deep feature representations of images in those subsets. Centers modeling the subsets are learned by using distance metric learning. The second proposed method uses discriminative common vectors to represent image features in the subsets, and entire subset is approximated with an affine hull in this approach. Discriminative common vectors are subset centers that are projected onto a new feature space where the combined within-class variances coming from all subsets are removed. Our proposed methods can also be considered as distance metric learning methods using triplet loss function where the learned subcluster centers are the selected anchors. This procedure yields to applying distance metric learning to quantized data and brings many advantages over using classical distance metric learning methods. We tested proposed methods on various face recognition problems using image sets and some visual object classification problems. Experimental results show that the proposed methods achieve the state-of-the-art accuracies on the most of the tested image datasets.
Clinicopathological Features and Prognosis of Invasive Micropapillary Carcinoma Compared to Invasive Ductal Carcinoma-NOS: Worse or Better?

OBJECTIVE To evaluate whether there are differences in invasive micropapillary carcinoma (IMPC) and invasive ductal carcinoma-NOS (IDC-NOS) according to the clinicopathological features and prognosis including molecular subtypes. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Pathology, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey, from 2003 to 2016. METHODOLOGY Operated breast cancer cases (58 IMPC + 326 IDC-NOS), with long-term follow-up findings (cases followed up until 2020), were reviewed. The cases, whose other component was only IDC-NOS, were included in the mixed IMPC group. The clinical features, including clinical presentation, treatments, and follow-up information were obtained from the patient clinical database. The IMPC cases included in the study were re-examined, and micropapillary tumour components were confirmed based on the criteria set by the World Health Organisation (WHO). The clinicopathological findings, recurrence, and survival data of both groups were compared. In addition, IDC-NOS was divided into the molecular subgroups and compared with IMPC cases in terms of 5-year overall survival (OS). RESULTS There was no significant difference between the two groups for the distribution of molecular subtypes. There was a statistically significant difference among the nuclear grade, tumour size, nodal status, lymphovascular, and perineural invasion. In the first 5-year period, the OS rate for IDC-NOS and IMPC was 90.8% and 86.2% (p<0.05). The 5-year OS rate of luminal A, luminal B, HER2, triple negative (TN), and IMPC patients was 97.6%, 91.3%, 90%, 70%, and 86.2%, respectively (p<0.05). The OS rate in patients with TN and IMPC was similar which was found significantly lower than the other groups (luminal A, luminal B, and HER2). The median OS was 51.3 months and 53.9 months for the patients with TN and IMPC, respectively (p<0.001). This difference disappeared in the 10th and 15th years of follow-up. CONCLUSION The majority of the deaths in IMPC occurred within the first 5 years. The 5-year OS rates were similar in the TN and IMPC patients. The survival pattern of IMPC is parallel with TN, Therefore, clinical, therapeutic, and prognostic evaluation in IMPC can be done like TN. KEY WORDS Invasive ductal carcinoma, Invasive micropapillary carcinoma, Survival.
Metal–Metal Bond Umpolung in Heterometallic Extended Metal Atom Chains

Understanding the fundamental properties governing metal–metal interactions is crucial to understanding the electronic structure and thereby applications of multimetallic systems in catalysis, material science, and magnetism. One such property that is relatively underexplored within multimetallic systems is metal–metal bond polarity, parameterized by the electronegativities (χ) of the metal atoms involved in the bond. In heterobimetallic systems, metal–metal bond polarity is a function of the donor–acceptor (Δχ) interactions of the two bonded metal atoms, with electropositive early transition metals acting as electron acceptors and electronegative late transition metals acting as electron donors. We show in this work, through the preparation and systematic study of a series of Mo2M(dpa)4(OTf)2 (M = Cr, Mn, Fe, Co, and Ni; dpa = 2,2′-dipyridylamide; OTf = trifluoromethanesulfonate) heterometallic extended metal atom chain (HEMAC) complexes that this expected trend in χ can be reversed. Physical characterization via single-crystal X-ray diffraction, magnetometry, and spectroscopic methods as well as electronic structure calculations supports the presence of a σ symmetry 3c/3e– bond that is delocalized across the entire metal-atom chain and forms the basis of the heterometallic Mo2–M interaction. The delocalized 3c/3e– interaction is discussed within the context of the analogous 3c/3e– π bonding in the vinoxy radical, CH2CHO. The vinoxy comparison establishes three predictions for the σ symmetry 3c/3e– bond in HEMACS: (1) an umpolung effect that causes the Mo–M interactions to become more covalent as Δχ increases, (2) distortion of the σ bonding and non-bonding orbitals to emphasize Mo–M bonding and de-emphasize Mo–Mo bonding, and (3) an increase in Mo spin population with increasing Mo–M covalency. In agreement with these predictions, we find that the Mo2···M covalency increases with increasing Δχ of the Mo and M atoms (ΔχMo–M increases as M = Cr < Mn < Fe < Co < Ni), an umpolung of the trend predicted in the absence of σ delocalization. We attribute the observed trend in covalency to the decreased energic differential (ΔE) between the heterometal orbital and the σ bonding molecular orbital of the Mo2 quadruple bond, which serves as an energetically stable, “ligand”-like electron-pair donor to the heterometal ion acceptor. As M is changed from Cr to Ni, the σ bonding and nonbonding orbitals do indeed distort as anticipated, and the spin population of the outer Mo group is increased by at least a factor of 2. These findings provide a predictive framework for multimetallic compounds and advance the current understanding of the electronic structures of molecular heteromultimetallic systems, which can be extrapolated to applications in the context of mixed-metal surface catalysis and multimetallic proteins.