Miracle-dz/UniFAR-FTUs huggingface dataset:
Bypassing primary stroke centre reduces delay and improves outcomes for patients with large vessel occlusion

Objective In large-vessel occlusion, endovascular therapy is superior to medical management alone in achieving recanalisation. Reducing time delays to revascularisation in patients with large-vessel occlusion is important to improving outcome. Patients and methods A campaign was implemented in the Central Denmark Region targeting the identification of patients with large-vessel occlusion for direct transport to a comprehensive stroke centre. Time delays and outcomes before and after the intervention were assessed. Results A total of 476 patients (153 pre-intervention and 323 post-intervention) were included. They were treated with either intravenous tissue plasminogen activator or endovascular treatment (alone or in combination with intravenous tissue plasminogen activator). Endovascular therapy patients’ median system delay was reduced from 234 to 185 min (adjusted relative risk delay 0.79 (95% confidence interval: 0.67–0.93)). The in-hospital delay was the main driver with an adjusted relative risk delay of 0.76 (confidence interval: 0.62–0.94), while pre-hospital delay was almost significantly reduced with an adjusted relative delay of 0.86 (confidence interval: 0.71–1.04). This was achieved without increasing the intravenous tissue plasminogen activator-treated patients’ delay. Significantly more patients treated with endovascular therapy in the post-interventional period achieved functional independence (62% versus 43%), corresponding to an adjusted odds ratio of 3.08 (95% confidence interval: 1.08–8.78). Conclusion Direct transfer of patients with suspected large-vessel occlusion to a comprehensive stroke centre leads to shorter treatment times for endovascular therapy patients and is, in turn, associated with an increase in functional independence. We recorded no adverse effects on intravenous tissue plasminogen activator treatment times or outcome.
Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential ‘Seed’ and ‘Soil’ Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers

Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a cell–cell adhesion protein conferring heterotypic and homotypic interactions between cells of the same type and different types. It is aberrantly expressed in various cancer types and has been shown to be a regulator of cancer metastasis. In the present study, we investigated potential roles of ALCAM in the peritoneal transcoelomic metastasis in gastrointestinal cancers, a metastatic type commonly occurred in gastro-intestinal and gynaecological malignancies and resulting in poor clinical outcomes. Specifically, we studied whether ALCAM acts as both a ‘seed’ receptor in these tumour cells and a ‘soil’ receptor in peritoneal mesothelial cells during cancer metastasis. Gastric cancer and pancreatic cancer tissues with or without peritoneal metastasis were compared for their levels of ALCAM expression. The impact of ALCAM expression in these tumours was also correlated to the patients’ clinical outcomes, namely peritoneal metastasis-free survival. In addition, cancer cells of gastric and pancreatic origins were used to create cell models with decreased or increased levels of ALCAM expression by genetic knocking down or overexpression, respectively. Human peritoneal mesothelial cells were also genetically transfected to generate cell models with different profiles of ALCAM expression. These cell models were used in the tumour-mesothelial interaction assay to assess if and how the interaction was influenced by ALCAM. Both gastric and pancreatic tumour tissues from patients who developed peritoneal metastases had higher levels of ALCAM transcript than those without. Patients who had tumours with high levels of ALCAM had a much shorter peritoneal metastasis free survival compared with those who had low ALCAM expression (p = 0.006). ALCAM knockdown of the mesothelial cell line MET5A rendered the cells with reduced interaction with both gastric cancer cells and pancreatic cancer cells. Likewise, levels of ALCAM in both human gastric and pancreatic cancer cells were also a determining factor for their adhesiveness to mesothelial cells, a process that was likely to be triggered the phosphorylation of the SRC kinase. A soluble ALCAM (sALCAM) was found to be able to inhibit the adhesiveness between cancer cells and mesothelial cells, mechanistically behaving like a SRC kinase inhibitor. ALCAM is an indicator of peritoneal metastasis in both gastric and pancreatic cancer patients. It acts as not only a potential peritoneal ‘soil’ receptor of tumour seeding but also a ‘soil’ receptor in peritoneal mesothelial cells during cancer metastasis. These findings have an important therapeutic implication for treating peritoneal transcoelomic metastases.
Discriminatory models' adaptation in small and medium sized health care entities

The article presents the utilization of discriminatory analysis in small and medium sized hospitals. The discriminatory models are used to estimate the probability of researched hospitals bankruptcy. The financial distress is tested with two popular models, one foreign (the Altman Z’’Score Model) and one domestic (the Mączyńska Model). The authors also construct their own model, adapted to the specification of medical activity. The results indicate that the author’s model is much more suitable for the small and medium sized hospitals, as the rate of prediction is highest. It may indicate that in the health care sector, particularly in small and medium sized companies, different phenomena occur, which affect these companies’ financial distress. Despite this, this study indicates that the proposed model is one of the useful tools for their evaluation, especially when combined with other financial as well as non-financial tools. Finally, it was possible to verify the hypothesis that it is possible to create a discriminatory model dedicated to SMEs hospitals, which results are more accurate than using different, not adjusted to health care sector specifics, discriminatory models.
When good becomes bad: the role of corporate crisis and issue congruence

Abstract This study investigates how different types of corporate crises and issue congruence interplay in determining the effects of a previous corporate social responsibility (CSR) initiative in a company facing a crisis. The findings suggest that a previous CSR initiative can more effectively protect a company’s image when the company has a competence-related rather than a morality-related crisis. In addition, when the social cause of the CSR initiative is congruent with the issue of the negative event, consumers will respond more negatively than when there is no issue congruence between CSR and the negative event. Moreover, there is an interaction effect between issue congruence and the type of crisis. That is, when a firm has a moral crisis that is associated with the social cause supported in a previous CSR initiative, consumers perceive the firm’s CSR initiative to have been less sincere than if the firm were facing a competence-related crisis.
Peran Kebijakan Pemerintah Dalam Memoderasi Pengaruh Strategi Bisnis Terhadap Kinerja Usaha

This study aims to determine the effect of business strategies on business performance and the influence of business strategies on business performance through government policies. The sample in this study was food and beverages MSMEs in Pekanbaru. In this study,data was collected in two ways (library research and field research). This study used Moderated Regression Analysis (MRA). Based on the results of the test, it was concluded that business strategies influences government policy. This result shows that business strategies can determine the level of business performance. A business that has a business strategy that is directed precisely and effectively will produce good performance for the business. In addition, the results of the study also concluded that business strategies did not affect business performance through government policies. This is because most businesses that are run are continuing from their parents' business, so that they have a fixed market share and customers. So that government policies do not mediate the influence of business strategies on company performance.
Evaluation of Job Satisfaction and Job Related Stress Among Community Pharmacists in North Khartoum and its Impact on Providing Pharmaceutical Care Services

Introduction Pharmacists and pharmaceutical care services are among the most important tools in providing health services to the society. Pharmacists as the key players in presenting health services, critically impact on the health of the society and if they suffer low job satisfaction, their dissatisfaction may relatively threaten health in the society. This study was conducted to determine Sudanese community pharmacists’ job satisfaction and additionally, some causes of dissatisfaction among community pharmacists and their impact on providing pharmaceutical care services have been evaluated. Method The questionnaire was designed after reviewing relevant Literature in addition, The Job Satisfaction survey was used to measure the level of community pharmacists’ satisfaction with their current jobs, and the Toronto Alexithymia Scale (TAS-20) was used to evaluate emotional experience and awareness. Results and Discussion Generally low scores of job satisfaction were concluded among pharmacists while most of them were highly satisfied with being pharmacist. Conclusion Low levels of job satisfaction which were found among Sudanese community pharmacists could be considered as a deficiency of health system in Sudan. Fortunately, inherent interest in the pharmacy profession found among Sudanese pharmacists is an optimistic point at which policy-makers could develop their modifying policies. Health policy-makers must endeavor to take other steps to issue solutions for this current problem.
Anti-Inflammatory and Anti-Bacterial Effects of Mouthwashes in Intensive Care Units: A Systematic Review and Meta-Analysis

Mouthwashes are used as oral care for critical care patients to prevent infections. However, there are conflicting data concerning whether mouthwashes are needed as a part of daily oral care for critical care patients. This study aimed to evaluate the anti-inflammatory and anti-bacterial effects of mouthwashes for critical care patients. The PubMed, EMBASE, CENTRAL, and grey literature databases were searched by descriptors combining population (intensive care unit patients) and intervention (mouthwashes). After the screening, only randomized controlled trials (RCTs) evaluating the anti-inflammatory and anti-bacterial effects of mouthwashes in patient critical care were included. From the 1531 articles, 16 RCTs satisfied the eligibility criteria for systematic review and 10 were included in the meta-analyses. A significant difference was found in the incidence of ventilator associated pneumonia (VAP) (odds ratio [OR] 0.53, 95% confidential interval [95% CI] 0.33 to 0.86) between the mouthwash and placebo groups, while no significant difference was found in the mortality (OR 1.49, 95%CI 0.92 to 2.40); the duration of mechanical ventilation (weighted mean difference [WMD] −0.10, 95%CI −2.01 to 1.81); and the colonization of Staphylococcus aureus (OR 0.88, 95%CI 0.34 to 2.30), Escherichia coli (OR 1.19, 95%CI 0.50 to 2.82), and Pseudomonas aeruginosa (OR 1.16, 95%CI 0.27 to 4.91) between the two groups. In conclusion, mouthwashes were effective in decreasing the incidence of VAP. Thus, mouthwashes can be used as part of daily oral care for critical care patients.
Highly Effective Frontal Stunning Procedure Using a Pneumatic Penetrating Captive Bolt in Water Buffaloes

Simple Summary Water buffalo meat and milk consumption has increased in recent years. This species is difficult to stun due to its skull conformation, affecting proper and effective stunning using conventional equipment. The objective of this study was to evaluate the stunning procedure of water buffaloes, using pneumatic mechanical stunning equipment most used in the American continent, by assessing an adequate site for frontal stunning. The results showed that the anatomical site proposed by the authors had a 95% effectiveness at the first shot. This finding is highly important as it significantly improves the welfare of water buffaloes taken to slaughter, one of the most stressful stages of their lives, providing a prompt unconscious state, as in cattle. Abstract An effective frontal stunning procedure in water buffaloes was assessed using a pneumatic penetrating captive bolt (PPCB) with high air pressure. The study contemplated two phases; first, 352 buffaloes and 168 post-mortem heads were evaluated to determine the most effective anatomical site for stunning. Then, the second phase (n = 182) was used to validate the stunning procedure at the discovered anatomical site in the first phase, which was located 8 cm dorsal above the middle of the forehead on an “X” formed between the eyes and the base of the contralateral horns, and 2 cm lateral, avoiding the midline, where the skull tended to narrow. A total of 95.1% of buffaloes received effective stunning at the first shot with evidence of the presence of collapse, absence of rhythmic breathing, and absence of ocular reflexes (corneal and palpebral). There were no differences in the stunning efficacy by sex, breed, or skull thickness. These findings demonstrated that stunning with a PPCB at pressures of 1379–1516.8 KPa (200–220 pounds per square inch (psi)) in the site reported here produces a highly effective stunning at the first shot in water buffaloes.
The Impact of Corporate Attributes on the Extent of Voluntary Disclosure and Reporting by Listed Companies in Bangladesh

The aim of this study is to determine the extent and level of voluntary reporting of the listed companies in Bangladesh. It also explores the potential effects of corporate governance characteristics, ownership aspects and firm characteristics on voluntary reporting. The sample of the study consists of 123 companies with 861 firm year observations listed in the Dhaka Stock Exchange, Bangladesh for the year 2004 to 2010. To measure the extent of reporting self constructed checklists have been used which contains 97 items focusing on corporate social reporting, corporate environmental reporting and corporate sustainability reporting. The study found that level of total voluntary reporting in the annual reports of listed Bangladeshi companies is low. However, a gradual increase in the extent of voluntary reporting and its categories has been noticed over the period of study. Through regression analysis, the outcomes show significant positive relationship between voluntary reporting and firm size, firm's liquidity, percentage of independent directors and board structure while it has significant negative relationships with market categories, company age and number of independent directors. However, audit committee and board size have a non-significant relationship with voluntary reporting of the listed Bangladeshi companies over the examined period.
Collaboration in a Best Value Project - A case study of Best Value Approach (BVA) in the Norwegian Construction Industry

II CHAPTER 1 INTRODUCTION . 1 1.1 BACKGROUND . 1 1.2 RESEARCH AREA . 3 1.3 PROBLEM STATEMENT . 5 1.4 EMPIRICAL SETTING . 7 1.5 OUTLINE OF THE THESIS . 7 CHAPTER 2 RESEARCH METHODOLOGY . 8 2.1 RESEARCH STRATEGY . 8 2.2 RESEARCH DESIGN . 12 2.3 DATA COLLECTION . 14 2.3.1 Primary Data . 16 2.3.2 Secondary Data . 18 2.4 ANALYTICAL PROCESS . 19 2.5 QUALITY OF THE RESEARCH . 24 CHAPTER 3 THEORETICAL BACKGROUND . 27 3.1 CONSTRUCTION INDUSTRY . 27 3.2 COLLABORATION AND ITS TWO FACETS: COORDINATION AND COOPERATION . 30 3.3 HOW COOPERATION AND COORDINATION INFLUENCE COLLABORATION . 31 3.3.1 The first perspective: Coordination . 31 3.3.2 The second perspective: Cooperation . 35 3.4 EARLY INVOLVEMENT OF SUPPLIERS . 39 3.5 BEST VALUE APPROACH . 40 3.5. 1 Roles and Responsibilities . 48 3.5. 2 Weekly Risk Report (WRR) . 49 3.6 HOW BVA INFLUENCES COORDINATION . 50 3.7 HOW BVA INFLUENCES COOPERATION . 52 3.8 THEORETICAL FRAMEWORK SUMMARY . 54 CHAPTER 4 EMPIRICAL FINDINGS AND ANALYSIS . 56 4.1 MOTIVATION FOR IMPLEMENTING BVA . 56 4.2 ABOUT THE PROJECTS . 57 4.3 COLLABORATION AND ITS TWO FACETS: COORDINATION AND COOPERATION . 58 4.3.1 Early involvement of supplier . 59 4.3.2 Information sharing . 61 4.3.3 Defining roles and responsibility . 66 0980011 0956257 GRA 19703
Assessment of knowledge sharing processes between academicians and decision makers towards the sustainable development of green infrastructure based of the example of environmental governance in Akershus and Oslo

It has been a rapid growth of interest to the potential benefits of green infrastructure in the environmental governance along with the balancing densification and greening processes for the sustainable development. In that case an efficient interplay between science and policy, “coproduction of science and policy”, becomes enormously important. Therefore, aim of this thesis is to gain a deeper understanding of the current level of science–policy interface, especially in the area of knowledge management processes that surround the both groups of actors. Data for the mixed analysis was collected by using semi-structured face to face interviews from 63 participants who were involved into environmental governance in Akershus and Oslo. Analyzed units were separated into the two major groups. The Theory of Planned Behavior (TPB) was used to explore the behavioral response of actors towards the knowledge management processes. Qualitative data analysis showed that groups of actors have as convergence or divergence points that can directly influence on their mismatch or similarity in interests close cooperation in the areas on environmental area. In particular, finding indicated that stumbling blocks of knowledge sharing among the decision maker’s group were associated with knowledge networking, lack or insufficient amount of knowledge, problem with knowledge source selection and knowledge use, effectiveness of knowledge transferring into policy, and communication barrier. While, among the academician’s group revealed knowledge networking barriers, effectiveness of knowledge sharing, political interference into process, motivation and willingness barriers, and lack of understanding policy process. Quantitative analysis showed a direct and indirect significant positive associations of the behavioral actor's Intention with the several variables that describe the knowledge sharing processes of the actors, along with an extended model variables. Findings, that revealed challenges and capacity gaps in relationships between scientists and decision-makers and can be the serious constrains toward the sustainable development of environment in the area, gave the possibilities to make conclusions and propose the future recommendations for the sustainable development of environment in the area.
Marketing Communication Strategy To Improve Tourism Potential

One of the main cultural attractions and the main attraction of tourism in the Kuningan regency is Curug Putri Palutungan. The tourism potential of the Kuningan regency was also supported by good access and transportation facilities. To reach the tourist attraction area that once was separated by many rivers, several bridges were built to facilitate tourists the tourist attraction. The tourist potential of the Curug Putri Palutungan is a mixture of the natural charm of mountainous forests and clear waterfalls, backed by a fresh mountain air that challenges you to explore the nature of the mystery of the forest. In this article, the authors use a qualitative method when conducting descriptive studies on the object of writing, because this method is an appropriate method to search for social fields and in particular communication. Qualitative writing methods that will be used to better understand the phenomena related to psychological aspects, behavior, attitudes, responses, opinions, feelings, desires and desires of a person or group. The marketing communication strategy of the Office of Youth, Sports, and Tourism to increase the tourism potential of the regency of Curug Putri Palutungan is one of them through advertising, that is, the installation of banners/billboards, print media advertising, online media advertising, Kuningan FM radio ads.
PRÁTICAS CULTURAIS SOBRE ALEITAMENTO MATERNO ENTRE FAMÍLIAS CADASTRADAS EM UM PROGRAMA DE SAÚDE DA FAMÍLIA

Objetivou-se identificar as praticas culturais em relacao ao aleitamento materno entre familias cadastradas em um PSF. Estudo descritivo, exploratorio, realizado em Pentecoste - Ceara, com 15 maes que demonstraram algum fator restritivo ao aleitamento. A coleta de dados ocorreu por meio de observacao direta e entrevista semi-estruturada e, apos analise, emergiram as categorias empiricas: prazer em amamentar e prevencao de doencas; influencia da familia/comunidade; e dificuldade em manter a amamentacao. As maes verbalizaram dificuldades na pratica da amamentacao, ausencia de um suporte adequado do servico de saude que envolva fatores nao somente biologicos, mas no âmbito social e cultural. Conclui-se que ha distanciamento entre o discurso cientifico e as praticas culturais do dia–a-dia dessas familias.
AN ASSESSMENT OF INDONESIA’S MONETARY INTEGRATION WITH OIL EXPORTER COUNTRIES IN ISLAMIC NATIONS: EVIDENCE FROM PANEL DATA

The paper aims to assess the monetary integration between Indonesia and oil exporting countries in Islamic countries. Increasing the oil trade intensity between Indonesia and oil-producing countries can drive monetary integration among them. This study applies the Optimum Currency Area (OCA) index to measure the degree of monetary integration between Indonesia and 21 oil-producing countries in the OIC. The results exhibit that the majority of oil-producing countries are strongly integrated with Indonesia. The panel regression test highlights two variables – the inflation similarity and trade openness – which had a significant effect on the OCA. This study provides an important policy base for Indonesia, primarily in improving its relations with oil-producing countries. Two channels – trade openness and maintaining harmonious price stability – are the entry point for Indonesia to integrate with oil countries.
CAPITAL STRUCTURE, LIQUIDITY AND FINANCIAL PERFORMANCE OF THE FIRMS IN CEMENT AND SUGAR INDUSTRIES OF PAKISTAN

This research examines the impact of firm capital structure and liquidity on the financial performance of sugar and cement sector firms in Pakistan. The study used the secondary data of 30 firms randomly selected for the period 2005 to 2017. The data was analyzed through statistical tools like correlation and regression. The results revealed that the capital structure proxies have a negative correlation with financial performance proxies of these sector firms. The results indicated that debts to equity ratio and the fund capital ratio has a negative insignificant impact however the debts ratio and Funded debts ratio were found having a negative significant impact on the financial proxies of these selected firms. The results indicated a positive correlation of the liquidity with the financial performance of these firms. The results demonstrating positive effect of current and quick ratios on the financial performance proxies of these firms. The study has some meaningful insights for the financial managers and decision makers of these firms.