Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between thermal characteristics of permeability and microstructure of Ni-Zn Ferrites

Relationship between thermal characteristics of permeability and microstructure of Ni-Zn ferrite were investigated. In non-stoichiometric (Fe 2 O 3 i = Is2/|K|, and in spinel ferrite the anisotropy K is a cubic anisotropy (Kc) originated in Fe3+. In this group of ferrite, however, the secondary phases give pressure to the spinel phases and the uniaxial anisotropy (Ku) generates by a partial strain of cubic system. So that, K is expressed in the sum of Kc and Ku. Thus, the change in the thermal characteristics of permeability can be explained in terms of the generation of secondary phases. At present, this model is quantitatively operational and is programed in the material design system for soft ferrites, MAGSYS-F.
Incidence of Parkinson’s disease and modifiable risk factors in Korean population: A longitudinal follow-up study of a nationwide cohort

Introduction We aimed to investigate the incidence of Parkinson’s disease (PD) by age and year for each sex as well as the modifiable risk factors for PD. Using data from the Korean National Health Insurance Service, 938,635 PD and dementia-free participants aged ≥40 years who underwent general health examinations were followed to December 2019. Methods We analyzed the PD incidence rates according to age, year and sex. To investigate the modifiable risk factors for PD, we used the Cox regression model. Additionally, we calculated the population-attributable fraction to measure the impact of the risk factors on PD. Results During follow-up, 9,924 of the 938,635 (1.1%) participants developed PD. The incidence of PD increased continuously from 2007 to 2018, reaching 1.34 per 1,000 person-years in 2018. The incidence of PD also increases with age, up to 80 y. Presence of hypertension (SHR = 1.09, 95% CI 1.05 to 1.14), diabetes (SHR = 1.24, 95% CI 1.17 to 1.31), dyslipidemia (SHR = 1.12, 95% CI 1.07 to 1.18), ischemic stroke (SHR = 1.26, 95% CI 1.17 to 1.36), hemorrhagic stroke (SHR = 1.26, 95% CI 1.08 to 1.47), ischemic heart disease (SHR = 1.09, 95% CI 1.02 to 1.17), depression (SHR = 1.61, 95% CI 1.53 to 1.69), osteoporosis (SHR = 1.24, 95% CI 1.18 to 1.30), and obesity (SHR = 1.06, 95% CI 1.01 to 1.10) were independently associated with a higher risk for PD. Discussion Our results highlight the effect of modifiable risk factors for PD in the Korean population, which will help establish health care policies to prevent the development of PD.
Defect-related tunneling mechanism of efficiency droop in III-nitride light-emitting diodes

The quantum efficiency of GaN-based light-emitting diodes (LEDs) is investigated at temperatures 77–300 K. It is found that the efficiency droop is due to a decrease in the internal quantum efficiency (IQE) in the low-energy part of the emission spectrum. The efficiency starts to decrease at a temperature independent forward voltage of Umax≈2.9 V. At this voltage tunneling current through the LED-structure begins to dominate. It is suggested that the external quantum efficiency droop is related to reduction of the IQE due to tunneling leakage of carriers from the quantum well (QW) to defect states in barriers, and to reduction of the injection efficiency by excess tunneling current under QW through deep defect states in barriers.
CONGRUENCES WITH FACTORIALS MODULO P

It is proved that the number of a ! {1,··· ,p" 1} which can be represented as a product of two factorials is at least 3 p+O(p 1/2 (logp) 2 ). This improves the result given by Garaev et.al. [Trans. Amer. Math. Soc. , 356 (2004)5089-5102]. Beyond this, we pose several conjectures.
Second-Harmonic Scattering on Orientational Fluctuations in Nematics

Although the nematic liquid-crystal phase is centrosymmetric, it can give rise to a considerable amount of optical second-harmonic signal. We show that in a well-oriented sample of 8CB this signal is spatially incoherent. We explain this non-linear scattering with a novel mechanism, whereby the normal orientational fluctuations of the nematic phase induce fluctuations of the local non-linear optical susceptibility tensor. We also discuss the polarization properties and wave vector dependence of this type of incoherent SHG.
Sorghum–mung bean combination snacks: Effect of extrusion temperature and moisture on chemical, functional, and nutritional characteristics

Nine samples were formulated using whole sorghum–mung bean (70:30) at variable extrusion conditions: barrel temperature (130–170°C) and feed moisture (14–18%), and their effect on properties of snacks was examined. The results revealed that the elevation in temperature and moisture increased the antioxidant activity (ferric‐reducing antioxidant power and 2,2‐DiPhenyl‐2‐Picryl hydrazyl hydrate) and total phenolic content. This could be attributed to that the release of bound phenolics is accelerated by the extrusion treatment. However, higher temperature and lower moisture improved the functional properties such as expansion ratio, in vitro protein digestibility, overall acceptability, and expected glycemic index (50–51) of the snacks. A positive correlation was seen among slowly digestible starch and expected glycemic index of the snacks, water solubility index, and expansion ratio. A strong positive correlation was observed among total phenolic content and antioxidant activity. Higher barrel temperature (170°C) and a lower feed moisture (14%) were found to be the best combination to produce nutritious sorghum–mung bean‐based snacks. Moreover, the snacks were found to be highly likeable among the sensory panel, which proves its commercialization properties.
Problem‐based instruction in mathematics and its impact on the cognitive results of the students and on affective‐motivational aspects

International studies on the knowledge of mathematics at the generalist‐class teaching level have indicated that Slovene students are quite skilled at computations, but have difficulties solving mathematical problems. This finding stimulated us to create a problem‐based instruction model. We wanted to find out whether the students in the experimental group, who received problem‐based instruction, would display greater ability in solving difficult mathematical problems compared to the group receiving conventional instruction. We were also interested in the students’ attitude towards mathematics. We formulated the experimental factor – problem posing and solving as the key math‐teaching activity – broadened the conventional mathematical problem by introducing into it several other types of problems and strategies of their solving. The efficiency of the model created was tested on a sample of 179 nine‐year‐old students. The results of the study are useful for the preparation of mathematics curriculum reform and important for the authors of maths materials for teachers and students. The research findings are of great value in the undergraduate education of teachers, as well as for qualified and practicing teachers and their further and regular professional training.
Individualized Multimodal Immunotherapy for Adults with IDH1 Wild-Type GBM: A Single Institute Experience

Simple Summary The standard of care for patients with primary glioblastoma multiforme consists of neurosurgery, radiochemotherapy, and maintenance chemotherapy. We added individualized multimodal immunotherapy to this treatment. During maintenance chemotherapy, immunogenic cell death immunotherapy (oncolytic virus injections and sessions of modulated electrohyperthermia) was inserted. After chemotherapy, active specific immunotherapy with dendritic cell vaccines (IO-Vac®) and modulatory immunotherapy were given. The manuscript describes the retrospective analysis of a group of 50 adults taken out of the database following a predefined clinical profile without further bias. We observed a clearly improved overall survival in comparison to published data. There were no major adverse reactions. The proposed treatment concept takes into account dynamic changes in tumor biology and tumor–host interaction, proposing an additional perspective besides the paradigm of protocol medicine in clinical trials. This report on real-world data has great scientific value and high relevance for patients. Abstract Synergistic activity between maintenance temozolomide (TMZm) and individualized multimodal immunotherapy (IMI) during/after first-line treatment has been suggested to improve the overall survival (OS) of adults with IDH1 wild-type MGMT promoter-unmethylated (unmeth) GBM. We expand the data and include the OS of MGMT promoter-methylated (meth) adults with GBM. Unmeth (10 f, 18 m) and meth (12 f, 10 m) patients treated between 27 May 2015 and 1 January 2022 were analyzed retrospectively. There were no differences in age (median: 48 y) or Karnofsky performance index (median: 80). The IMI consisted of 5-day immunogenic cell death (ICD) therapies during TMZm: Newcastle disease virus (NDV) bolus injections and sessions of modulated electrohyperthermia (mEHT); subsequent active specific immunotherapy: dendritic cell (DC) vaccines plus modulatory immunotherapy; and maintenance ICD therapy. There were no differences in the number of vaccines (median: 2), total number of DCs (median: 25.6 × 106), number of NDV injections (median: 31), and number of mEHT sessions (median: 28) between both groups. The median OS of 28 unmeth patients was 22 m (2y-OS: 39%), confirming previous results. OS of 22 meth patients was significantly better (p = 0.0414) with 38 m (2y-OS: 81%). There were no major treatment-related adverse reactions. The addition of IMI during/after standard of care should be prospectively explored.
Case Report: Add-on treatment with odevixibat in a new subtype of progressive familial intrahepatic cholestasis broadens the therapeutic horizon of genetic cholestasis

Odevixibat, an ileal bile acid transporter (IBAT) inhibitor, is effective for the treatment of pruritus in children diagnosed with progressive familial intrahepatic cholestasis (PFIC) type 1 and 2. There are no studies showing the efficacy of Odevixibat in children with different subtypes of PFIC. We describe the case of a 6-year-old girl with chronic cholestatic jaundice. In the last 12 months laboratory data showed high serum levels of bilirubin (total bilirubin x 2.5 ULN; direct bilirubin x 1.7 ULN) and bile acids (sBA x 70 ULN), elevated transaminases (x 3–4 ULN), and preserved synthetic liver function. Genetic testing showed homozygous mutation in ZFYVE19 gene, which is not included among the classic causative genes of PFIC and determined a new non-syndromic phenotype recently classified as PFIC9 (OMIM # 619849). Due to the persistent intensity of itching [score of 5 (very severe) at the Caregiver Global Impression of Severity (CaGIS)] and sleep disturbances not responsive to rifampicin and ursodeoxycholic acid (UDCA), Odevixibat treatment was started. After treatment with odevixibat we observed: (i) reduction in sBA from 458 to 71 μmol/L (absolute change from baseline: −387 μmol/L), (ii) reduction in CaGIS from 5 to 1, and (iii) resolution of sleep disturbances. The BMI z-score progressively increased from −0.98 to +0.56 after 3 months of treatment. No adverse drug events were recorded. Treatment with IBAT inhibitor was effective and safe in our patient suggesting that Odevixibat may be potentially considered for the treatment of cholestatic pruritus also in children with rare subtypes of PFIC. Further studies on a larger scale could lead to the increasing of patients eligible for this treatment.
Study of Serum FSH, LH and Prolactin in Female Albino Rats by Experimentally Creating Hypothyroidism

Objective: The current research was draft to contrast the variation in levels of Prolactin (PRL), Luteinizing Hormone (LH) and Follicle stimulating hormone (FSH) in female rodents by experimentally producing hypothyroidism.Methods: The Animal House of Dow University of Health science was used for the purpose of doing this research which was almost completed in a period of 10 months. The total number of 30 rodents of Wistar Albino species were taken to use in this research. Only adult healthy female rodents weighing between 180-200 gm were included in the study and animals which were found to be slow and lethargic were excluded from the study. These rats were separated into two parts by dividing them into two groups of fifteen animals each. The primary group received the regular normal diet and routine tap water for six weeks and was labeled as the control group whereas the other group was forced to accept Carbimazole (Antithyroid drug) through feeding tube by mixing 0.02% / ml of regular drinking water for a period of six weeks. After six weeks all the rats were slaughtered. The cardiac puncture of animal was done in order to collect blood. Analysis of Follicle Stimulating Hormone, Luteinizing Hormone and Prolactin was carried out by using the ELISA kits on serum of animal which was centrifuged and separated.Results: The result observed for control group showed a mean value ± standard deviation(SD) of 5.13 ± 1.39 mIU/ml for Follicle Stimulating Hormone. In the same group the mean value ± SD observed for Luteinizing Hormone was 8.38 ± 16.02 mIU/ml and for PRL was 0.40 ± 0.05 ng/ml respectively. The second group that is the hypothyroid group revealed a mean value ± (SD) of 5.89 ± 1.63 mIU/ml for Follicle Stimulating Hormone. For Luteinizing Hormones in hypothyroid group, the mean value ± SD turned out to be 9.30 ± 13.34 mIU/ml whereas the mean value ± SD observed for Prolactin in hypothyroid group was 0.62 ± 0.12 ng/ml. The information was entered on SPSS version 16. This information was analysed by applying an independent sample t-test in between the two groups to compare the levels of Follicle Stimulating Hormone, Luteinizing Hormone and PRL. The p-value was observed which turned out to be insignificant for Follicle Stimulating Hormone and Luteinizing Hormone but quite remarkable for Prolactin.Conclusion: Hypothyroidism created by an antithyroid drug (Carbimazole) leads to a remarkable rise in the levels of PRL regardless of the changes in levels of gonadotropins which may lead to the sterility in females.
Safety and rapid response of dabrafenib and trametinib therapy during hyperbilirubinemia in metastatic melanoma

This case report describes the occurrence of hyperbilirubinemia as a complication of metastatic melanoma. A 72-year-old male patient was diagnosed with BRAF V600E-mutated melanoma with metastases in the liver, lymph nodes, lungs, pancreas, and stomach. Due to a lack of clinical data and specific guidelines for the treatment of mutated metastatic melanoma patients with hyperbilirubinemia, a conference of specialists debated between initiating treatment or providing supportive care. Ultimately, the patient was started on the combination therapy of dabrafenib and trametinib. This treatment resulted in a significant therapeutic response via normalization of bilirubin levels and an impressive radiological response of metastases just one month post-treatment initiation.
Validation of the French Versions of the Flourish Index and the Secure Flourish Index

Abstract Individual well-being is generally thought of from the perspective of the risk factors which might compromise it. Assuming that positive dimensions of well-being are also worth considering, VanderWeele and Wȩziak-Białowolska et al. developed and tested the Flourish Index (FI) and the Secure Flourish Index (SFI). These 10- and 12-item questionnaires, respectively, measure 5 and 6 dimensions of human flourishing. This article presents the translation of these indexes into French (as FI–F and SFI–F) and the assessment of their psychometric properties on a sample of 2,376 French-speaking respondents. The validity and reliability indicators used by Wȩziak-Białowolska et al. were calculated for our French indexes and found to be very close to theirs. Item groupings were confirmed using correlation and factor analyses. The hierarchical structure of both French indexes matched the English indexes’ second-order and bi-factor model analyses. Reliability and construct validity were good. The brief time required to complete the FI–F or SFI–F and their excellent psychometric properties make them very promising tools for research on the general well-being of Francophone populations.
The Monsoon Year — A New Concept of the Climatic Year in the Tropics

The concept of “monsoon year” is proposed as a unit year of climatic anomalies (i.e., the climatic year) in the tropics. This monsoon year is defined as one year starting just before the northern summer monsoon season. It is also argued that this climatic year in the tropics is physically based upon the characteristic nature of the coupled ocean/land/atmosphere system over the Asian monsoon/Pacific Ocean sector.
The Fundamental Role of Lipids in Polymeric Nanoparticles: Dermal Delivery and Anti-Inflammatory Activity of Cannabidiol

This report presents a nanoparticulate platform for cannabidiol (CBD) for topical treatment of inflammatory conditions. We have previously shown that stabilizing lipids improve the encapsulation of CBD in ethyl cellulose nanoparticles. In this study, we examined CBD release, skin permeation, and the capability of lipid-stabilized nanoparticles (LSNs) to suppress the release of IL-6 and IL-8. The nanoparticles were stabilized with cetyl alcohol (CA), stearic acid (SA), lauric acid (LA), and an SA/LA eutectic combination (SALA). LSN size and concentration were measured and characterized by differential scanning calorimetry (DSC), in vitro release of loaded CBD, and skin permeability. IL-6 and IL-8 secretions from TNF-α-induced HaCaT cells were monitored following different LSN treatments. CBD released from the LSNs in dispersion at increasing concentrations of polysorbate 80 showed non-linear solubilization, which was explained by recurrent precipitation. A significant high release of CBD in a cell culture medium was shown from SALA-stabilized nanoparticles. Skin permeation was >30% lower from SA-stabilized nanoparticles compared to the other LSNs. Investigation of the CBD-loaded LSNs’ effect on the release of IL-6 and IL-8 from TNF-α-induced HaCaT cells showed that nanoparticles stabilized with CA, LA, or SALA were similarly effective in suppressing cytokine release. The applicability of the CBD-loaded LSNs to treat topical inflammatory conditions has been supported by their dermal permeation and release inhibition of pro-inflammatory cytokines.
Host Qualities: Conceptualising Listeners’ Expectations for Podcast Hosts

ABSTRACT This article empirically identifies and conceptualises listener expectations of podcast hosts based on a general and open research question concerning which expectations podcast listeners have for podcast hosts. From an explorative empirical study of 20 online focus group interviews with Danish radio- and podcast listeners, the article concludes that the expectations of podcast hosts are grouped into three categories: knowledge, storytelling, and parasocial relationship. The three categories have underlying themes: some are distinct expectations for podcast hosts; others are of a more general character. Additionally, the study contributes to a better understanding of the inherent qualities of podcasts as a medium and provides useful knowledge for podcast producers about user preferences.
Evaluation of a “Picture Assisted Illustration Reinforcement” (PAIR) System for Oral Hygiene in Children with Autism: A Double-Blind Randomized Controlled Trial

This study evaluated the potential of a novel pre-validated “Picture Assisted Illustration Reinforcement” (PAIR) communication system and conventional verbal techniques for Oral Health Education (OHE) in terms of dentition status, gingival health, oral hygiene status, and practices in 7- to 18-year-old children with Autism Spectrum Disorder (ASD). A double-blind randomized controlled trial was undertaken in a school for children with autism from July to September 2022. A total of 60 children were randomly assigned into two groups: a PAIR group (n = 30) and a Conventional group (n = 30). Cognition and pre-evaluation of all the children were assessed by standardized scaling measures. A pre-validated closed-ended questionnaire was administered to caregivers of both groups. At a 12-week post-intervention, a clinical examination was performed using the World Health Organization (WHO) Oral Health Assessment form 2013, gingival and Oral Hygiene Index Simplified (OHI-S). The gingival scores in the PAIR group (0.35 ± 0.12) exhibited a statistically significant decline in scores as compared to Conventional group (0.83 ± 0.37), p = 0.043. Meanwhile, the oral hygiene scores in the PAIR group and Conventional group were 1.22 ± 0.14 and 1.94 ± 0.15, respectively (p < 0.05). A significant improvement in oral hygiene practices was observed in the PAIR group. Incorporating the PAIR technique resulted in significant progress in child cognitive ability and adaptive behavior, which reduced gingival scores and improved oral hygiene scores, consequently improving oral hygiene practices among children with ASD.
Wave tank study of the damping of mm-scale wind waves by surface films

Presents new extended measurements of wind waves in the presence of artificial organic films, using two optical spectrum analysers, one measuring phase velocities and the other measuring variations of the wavenumber spectrum of the wind waves. It has been found that, in the presence of films, the observed phase velocities are closer to those of free linear gravity-capillary waves than they are in the case of clean water. This can be explained by the bound waves being more strongly damped than the free waves. The relation between bound and free waves is estimated from measurements of phase velocity. Wind ripple damping has been found to be maximum at wavelengths around 5-7 mm. This is in agreement with the predictions of the new mechanism, and it also agrees with field experiments using artificial slicks.
The central role of natural killer cells in preeclampsia

Preeclampsia (PE) is a disease that is unique to pregnancy and affects multiple systems. It can lead to maternal and perinatal mortality. The precise etiology of PE is unclear. Patients with PE may have systemic or local immune abnormalities. A group of researchers has proposed that the immune communication between the fetus and mother is primarily moderated by natural killer (NK) cells as opposed to T cells, since NK cells are the most abundant immune cells in the uterus. This review examines the immunological roles of NK cells in the pathogenesis of PE. Our aim is to provide obstetricians with a comprehensive and updated research progress report on NK cells in PE patients. It has been reported that decidual NK (dNK) cells contribute to the process of uterine spiral artery remodeling and can modulate trophoblast invasion. Additionally, dNK cells can stimulate fetal growth and regulate delivery. It appears that the count or proportion of circulating NK cells is elevated in patients with or at risk for PE. Changes in the number or function of dNK cells may be the cause of PE. The Th1/Th2 equilibrium in PE has gradually shifted to an NK1/NK2 equilibrium based on cytokine production. An improper combination of killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA)-C may lead to insufficient activation of dNK cells, thereby causing PE. In the etiology of PE, NK cells appear to exert a central effect in both peripheral blood and the maternal-fetal interface. To maintain immune equilibrium both locally and systemically, it is necessary to take therapeutic measures directed at NK cells.