Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent advances in poor HIV immune reconstitution: what will the future look like?

Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected patients, contributing to a dramatic reduction in AIDS morbidity and mortality. However, the factors affecting immune reconstitution are extremely complex. Demographic factors, co-infection, baseline CD4 cell level, abnormal immune activation, and cytokine dysregulation may all affect immune reconstitution. According to report, 10–40% of HIV-1-infected patients fail to restore the normalization of CD4+ T cell count and function. They are referred to as immunological non-responders (INRs) who fail to achieve complete immune reconstitution and have a higher mortality rate and higher risk of developing other non-AIDS diseases compared with those who achieve complete immune reconstitution. Heretofore, the mechanisms underlying incomplete immune reconstitution in HIV remain elusive, and INRs are not effectively treated or mitigated. This review discusses the recent progress of mechanisms and factors responsible for incomplete immune reconstitution in AIDS and summarizes the corresponding therapeutic strategies according to different mechanisms to improve the individual therapy.
Wordsmith: Examining the role hip-hop texts play in viewing the world

WORDSMITH: EXAMINING THE ROLE HIP-HOP TEXTS PLAY IN VIEWING THE WORLD by Crystal LaVoulle Originally the voice of a silenced group of inner city Black males, hip-hop culture contains a historical road map that chronicles the experiences of its members. This study attempted to examine hip-hop through the stories of adults who incorporateaspects of hip-hop culture into their daily lives. Specifically, this study investigated, “How is hip-hop a critical element in the lives of poets, artists, and educators who are actively and intimately involved in its music and culture? ” Additionally, this study will explore the following sub-questions: (1) What does it mean to be a member of the hip-hop community? (2) How does hip-hop inform the view of the world for participants in this study? This qualitative research study, framed by critical literacy, attempted to fill the void in the scholarship of hip-hop texts. Data collection included in-depth individual interviews, photoelicited interviews and music-elicited interviews, a group interview, and cultural artifacts. Narrative inquiry and analysis served as both the process and product used to describe the participants’ lives as members of the hip-hop community. Narrative analysis allowed the construction of cipher-styled presentation of the data collected. Using participants’ lived experiences, their individual stories are molded into a concise narrative. This narrative, told by members of the hip-hop community, may provide a context for other researchers seeking to understand the influence of hip-hop on everyday people around the world. WORDSMITH: EXAMINING THE ROLE HIP-HOP TEXTS PLAY IN VIEWING THE WORLD by Crystal LaVoulle
The New Economics of Industrial Policy

We discuss the considerable literature that has developed in recent years providing rigorous evidence on how industrial policies work. This literature is a signiﬁcant improvement over the earlier genera�on of empirical work, which was largely correla�onal and marred by interpreta�onal problems. On the whole, the recent crop of papers oﬀers a more posi�ve take on industrial policy. We review the standard ra�onales and cri�ques of industrial policy and provide a broad overview of new empirical approaches to measurement. We discuss how the recent literature, paying close aten�on to measurement, causal inference
GRATITUDE TRAINING TO REDUCE THE DEPRESSION LEVEL AMONG THE PATIENTS WITH CHRONIC KIDNEY FAILURE UNDERGOING THE HEMODIALYSIS THERAPY

ABSTRACT : The purpose of the study was to investigate the effectiveness of gratitude training on reducing depression levels among patients with chronic kidney failure undergoing hemodialysis therapy. The study used a single-subject experimental design with the A-B-A (Baseline A1-Treatment-BaselineA2) format to examine changes in individuals receiving the treatment. Two patients with chronic kidney failure who had undergone hemodialysis therapy for ≤2 years were selected as the participants. The level of depression was measured using Depression Anxiety Stress Scale (DASS)-42 and qualitatively measured through visual inspection. The hypothesis test results supported the effectiveness of gratitude training in reducing the depression level in patients with chronic kidney failure undergoing hemodialysis therapy.
Acute toxicity of some heavy metals to different species of aquatic insects

Two generalities might be drawn from these results: (a) the species of mayfly used was the most sensitive of the insects tested to all the metals that were checked; and (b) the insects seem to be less sensitive to the heavy metals than many fish that have been tested. As is the case with fish, relative toxicity of the heavy metals to aquatic insects varied widely with the test species. Therefore, statements comparing the toxicity of the metals to aquatic insects should indicate the test species and, conversely, the relative resistance of two species should be compared only for a specific toxicant. These TL/sub m/ values are a measure of the toxicity of some metals to certain aquatic insects under the experimental conditions specified. Such concentrations could be expected to cause mortality under most environmental conditions even for short exposure.
Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response

Simple Summary Worldwide, breast cancer is among the most frequently diagnosed cancers in women and the second leading cause of cancer-associated mortality in women. While tumor genetics contribute to therapies used to treat breast cancer and inform patient prognosis, modifications of histone proteins, which help organize the genetic material in cells into chromatin, can also influence therapeutic response and ultimately patient outcome. Here, we explore the role of enzymes that modify histone proteins in breast cancer. We discuss how these reversible, or “epigenetic”, changes to chromatin perturb the tumor environment and describe preclinical studies that provide a rationale for targeting chromatin-modifying enzymes in breast cancer. We build on existing preclinical data to connect epigenetic activity with changes in cells that support oncogenic growth and, when applicable, assess the current clinical status of treatments that target chromatin-modifying enzymes in breast cancer. Abstract Breast cancer pathogenesis, treatment, and patient outcomes are shaped by tumor-intrinsic genomic alterations that divide breast tumors into molecular subtypes. These molecular subtypes often dictate viable therapeutic interventions and, ultimately, patient outcomes. However, heterogeneity in therapeutic response may be a result of underlying epigenetic features that may further stratify breast cancer patient outcomes. In this review, we examine non-genetic mechanisms that drive functional changes to chromatin in breast cancer to contribute to cell and tumor fitness and highlight how epigenetic activity may inform the therapeutic response. We conclude by providing perspectives on the future of therapeutic targeting of epigenetic enzymes, an approach that holds untapped potential to improve breast cancer patient outcomes.
Plenary Autonomous Intersection Management Protocol for Heterogeneous Connected Vehicles

This paper proposes a centralized autonomous intersection management scheme for heterogeneous connected vehicles (HCVs). Contributions of this work are as follows. First, we sustainably classify heterogeneous vehicles with their distinctive safety-related characteristics. Second, we conduct a safe and efficient coordination algorithm with respect to some criteria such as vehicle types, road priorities and right of way rules. Third, we consider the impact of different road conditions, vehicle characteristics, load, and braking technology on the system performance. Forth, we demonstrate the efficiency of the system under various traffic densities with symmetric and asymmetric vehicle distribution. Besides, system performance is to be compared with traffic lights (TLs) scenarios in terms of throughput, average travel time (ATT), intersection busy time (IBT), channel busy rate (CBR), and packet loss rate (PLR) in various road conditions.
Development of an Automated and Continuous Analysis System for PM 2.5 and Chemical Characterization of the PM 2.5 in the Atmosphere at Seoul

An automated analysis system for water soluble constituents in has been developed. The system consists of a high capacity multi tube diffusion scrubber (MTDS), a low temperature particle impactor (LTPI), and two ion (anion and cation) chromatography (IC) systems. Atmospheric particles have been collected by passing sample air through a thermostated MTDS followed by a LTPI. This system allows simultaneous measurements of soluble ions in at 30 minutes interval. At the air sampling flow rate of 1.0L/min, the detection limits of the overall system are in the order of tens of . This system has been successfully used for the measurement of particulate components of Seoul air from April 2003 to January 2004. are the major ionic species for at Seoul. Among them, are the most abundant ions, contributed up to of the total and the concentrations were higher than those in any other urban sites in the world except for Chinese cities. There are high pollutant episodes which contribute about of annual average values of the major ions. During the episode, the all parcels were transported from the asian continent and were significantly neutralized. This suggests that aged and long range transported pollutants caused the high pollutant episodes. They showed a distinct daily and seasonal variations:they showed a peak in the early morning caused by the night-time accumulation of particulate matters. Atmospheric reactions including gas-to-particle reactions and inter-particle reactions and meteorological parameters including relative humidity and ambient temperature were described with related to the 5 concentrations. All of the ionic species showed higher concentrations during the spring than those for summer and winter.
Influence of Drying Temperature on Drying Kinetics and Appearance of Avocado Slices in Heat Pump Drying Process

The avocado is a nutritious fruit that originated from tropical countries such as Central and Southern America, and Southeast Asia. From the commercial point of view, it is an important fruit with a total world production is around eight million tons in 2020. Fresh avocados can be consumed directly or stored before advanced processing. The drying technique can be applied as an efficient post-harvesting technique to prolong the storage time of avocados. In this paper, heat pump drying experiments were performed to evaluate the influence of drying conditions on the drying time, the moisture diffusion coefficient, and the color change of avocado slices. It was obtained that color change can be decreased by increasing the drying temperature from 35 °C to 50 °C. Additionally, the effective moisture diffusivity was enhanced approximately two times by increasing temperature. It was suggested that a drying temperature of 50 °C should be used for the heat pump drying system operation and design to shorten drying time and prevented the quality of avocado. Additionally, empirical models were established to describe the drying behavior of avocados. The results indicated that the Page model can reflect well the evolution of moisture content over time with determination coefficient R2 greater than 0.996.
Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure, waist circumference, and fasting blood glucose

Introduction: Prior studies report conflicting evidence regarding exercise pressor and metaboreflex responses in individuals with metabolic syndrome (MetS). Purpose: To test the hypotheses that 1) exercise pressor and metaboreflex responses are exaggerated in MetS and 2) these differences may be explained by elevated resting blood pressure. Methods: Blood pressure and heart rate (HR) were evaluated in 26 participants (13 MetS) during 2 min of handgrip exercise followed by 3 min of post-exercise circulatory occlusion (PECO). Systolic (SBP), diastolic (DBP), and mean arterial pressure (MAP), along with HR and a cumulative blood pressure index (BPI), were compared between groups using independent samples t-tests, and analyses of covariance were used to adjust for differences in resting blood pressure, fasting blood glucose (FBG), and waist circumference (WC). Results: ΔSBP (∼78% and ∼54%), ΔMAP (∼67% and ∼55%), and BPI (∼16% and ∼20%) responses were significantly exaggerated in individuals with MetS during handgrip and PECO, respectively (all p ≤ 0.04). ΔDBP, ΔMAP, and BPI responses during handgrip remained significantly different between groups after independently covarying for resting blood pressure (p < 0.01), and after simultaneously covarying for resting blood pressure, FBG, and WC (p ≤ 0.03). Likewise, peak SBP, DBP, MAP, and BPI responses during PECO remained significantly different between groups after adjusting for resting blood pressure (p ≤ 0.03), with peak SBP, MAP, and BPI response remaining different between groups after adjusting for all three covariates simultaneously (p ≤ 0.04). Conclusion: These data suggest that exercise pressor and metaboreflex responses are significantly exaggerated in MetS independent of differences in resting blood pressure, FBG, or WC.
THE INFLUENCE OF LIQUIDITY, SOLVENCY, PROFITABILITY, AND COMPANY SIZE ON STOCK PRICES

Providing empirical evidence regarding liquidity, solvency, profitability, firm size on stock prices is the purpose of this research. Secondary data through the collection of financial statements of energy companies for 2017-2021 obtained through the official website of the Indonesia Stock Exchange (www.idx.co.id) and the Indonesia Finance Market (www.finance.yahoo.com) are data used in research. Using data in the form of company financial statements and company stock prices. The sampling technique used was purposive sampling. Path analysis with WarpPLS 7.0 software as the analysis tool is applied. With the results of the observation is the effect of liquidity, profitability, and company size with stock prices, however, solvency has no effect on stock prices.
GENUS OCIMUM IN TERMS OF MINERAL, NUTRIENT, CHEMICAL CONTENTS AND BIOLOGICAL ACTIVITY

In many regions, plants are the sole source of natural medicines. The numerous bioactive substances they contain have significant advantages in the prevention and treatment of many ailments. Determining the therapeutic characteristics of plants requires knowledge about their biological activity and essential oil contents. The mineral, nutritional, essential oil, and biological activity data for the genus Ocimum was gathered in this research. Several members of the genus Ocimum were found to engage in a wide variety of biological processes, as shown by the research findings. It has been discovered that this source may be very useful, particularly for its antioxidant and antibacterial properties. It's also said to contain naturally occurring minerals, nutrients, and essential oils. For this reason, plants belonging to the genus Ocimum are being considered as a potential valuable resource for use in the development of pharmaceuticals.
Parenting stress and Chinese preschoolers’ approaches to learning: a moderated mediation model of authoritative parenting and household residency

According to the family stress model, this study examined the relationship between parenting stress and preschoolers’ approaches to learning (ATL) in China, as well as the mediating effect of authoritative parenting and the moderating effect of household residency (migrant and native). A survey of 5,047 preschoolers’ parents (2,186 natives and 2,861 migrants) supports the proposed moderated mediation model. The results showed that after controlling for gender and age, parenting stress affected preschoolers’ development of ATL negatively. Authoritative parenting mediates the relationship between parenting stress and preschoolers’ ATL. Further, household residency moderated the relationship between authoritative parenting and preschoolers’ ATL. The findings of this study suggest that high levels of parenting stress are detrimental to the development of preschoolers’ ATL. And parents with low parenting stress are more likely to adopt authoritative parenting, which in turn fosters preschoolers’ ATL. In addition, native families’ authoritative parenting style are more conducive to fostering preschoolers’ ATL than migrant families. Finally, this study contributes to previous research by examining the mechanisms of parenting stress on preschoolers’ ATL and provides support for the extension of the family stress model. Importantly, it also informs efforts to improve ATL among preschoolers in Chinese migrant and native families.
Learning Needs of Patients with Cancer and a Pre-Existing Autoimmune Disease Who Are Candidates to Receive Immune Checkpoint Inhibitors

Simple Summary Our results can be used in clinical settings to facilitate patient–provider discussion. They can also be used to develop educational interventions to increase knowledge and decrease uncertainty. We identified seven key informational needs: (1) possible adverse events; (2) benefits of ICI; (3) ICI mechanism of action in the context of autoimmune disease; (4) management of flare-ups while receiving ICI; (5) reasons for stopping or modifying cancer or autoimmune disease treatment; (6) likelihood of autoimmune disease progression or organ damage; and (7) lifestyle changes that could help avoid adverse events. Abstract Patients with pre-existing autoimmune disorders and cancer considering immune checkpoint inhibitors (ICIs) need to receive balanced information about the benefits and risk of developing immune-related adverse events (irAEs) and flare-ups of their autoimmune disease. To assess the learning needs of patients with cancer and pre-existing autoimmune disease regarding ICI treatment, we interviewed 29 patients with autoimmune disease and cancer from a comprehensive cancer center, of whom 20 had received ICI and 9 were candidates to receive ICI at a US Cancer Center. In-depth semi-structured interviews were conducted from August 2021 and January 2022. Interviewee’s opinions and preferences about content and information delivery methods were collected. We recorded and transcribed interviews and analyzed them using thematic analysis. Half of the participants were female, and their median (SD) age was 62.9 (±10.9) years. The identified health information needs included the following: (1) information on irAEs and autoimmune disease flare-ups; (2) benefits of ICI; (3) ICI mechanism in the context of autoimmune disease; (4) management of flare-ups; (5) reasons for stopping or modifying cancer or autoimmune disease treatment; (6) likelihood of autoimmune disease progression or organ damage; and (7) lifestyle changes that could help avoid irAEs. Patients who had received ICI and those who had not yet received treatment reported similar needs, although patients who had received ICI had more questions about cancer treatment modifications. Patients also expressed the need to better understand when to contact their provider and how to share information with multiple providers. Most patients wanted to receive information in visual formats for review at home and at their own pace. Patients expressed interest in having educational tools to facilitate shared decision-making with their physicians, and they identified several areas of health information concerning therapy with ICI. They also highlighted the importance of communication among their various providers.
Hadith in the Ancient Schools of Law According to Joseph Schacht

In the 3rd century H, the traditions of the Prophet have been collected. In the sixth book (al-Kutub as-Sittah) only the traditions of the Prophet are prioritized. Before Asy-Syāfi‘ī (d. 204 H), in the ancient schools of law, the traditions of the Prophet received little attention. Based on this problem, the author tries to explore further how the hadith in ancient schools of law actually was according to Schacht. From two of Schacht's works: An Introduction to Islamic Law and The Origins of Muhammadan Jurisprudence, the author focuses on: 1). The ancient school of law according to Joseph Schacht; and 2). Hadith in ancient schools of law according to Joseph Schacht. The purpose of this discussion is to describe how Schacht's ideas about ancient schools of law and how hadiths are used by ancient schools of law. In this article the author uses a qualitative descriptive approach with documentary methods and historical analysis. The results of the study show that in the history of the development of legal doctrine, ancient schools of law were born from the activities of qādī (Islamic judges) and specialists who were concerned with legal issues. Their distinctive feature is geographical differences: Hijaz (Makkah and Medina), Iraq (Kufah and Basra), Syiria and Egypt. Their response to the popular practice and administrative regulations of the Umayyad dynasty (collapsed 132 H) gave birth to what is known as Islamic law. During the Abbasid dynasty, the ancient school of law changed into a new school of law based on loyalty to a teacher, which in turn formed groups such as the followers of Abū Ḥanīfah (d. 150 H), Mālik (d. 179 H), Sufyān aṡ-Ṡaurī ( d. 161 H), al-Auzā’ī (d. 157 H), and so on. The ancient legal schools had the same attitude towards hadith. They prioritize the traditions of the Companions rather than the traditions of the Prophet. This can be seen from Asy-Syāfi‘ī's polemic against the Medina and Iraqi schools. Other evidence is the distribution of the use of hadiths of the Prophet and traditions other than the Prophet in the book al-Muwaṭṭa’, Ᾱṡār Abū Yusūf and Ᾱṡār ash-Syaibānī.
Development of a microfluidic photochemical flow reactor concept by rapid prototyping

The transfer from batch to flow chemistry is often based on commercial microfluidic equipment, such as costly complete reactor systems, which cannot be easily tailored to specific requirements of technologies such as DNA-encoded library technology (DELT), in particular for increasingly important photochemical reactions. Customized photoreactor concepts using rapid prototyping technology offer a modular, flexible, and affordable design that allows for adaptation to various applications. In order to validate the prototype reactors, a photochemical pinacol coupling reaction at 368 nm was conducted to demonstrate the transfer from batch to flow chemistry. The conversion rates were optimized by adapting the design parameters of the microfluidic flow photoreactor module. Subsequently, the photoreactor module has been extended to an application with DNA-tagged substrates by switching to LEDs with a wavelength of 454 nm. The successful recovery of DNA confirmed the feasibility of the modular-designed flow photo reactor. This collaborative approach holds enormous potential to drive the development of DELT and flow equipment design.