Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing explicit strategies in force field adaptation.

In recent years, it has become increasingly clear that a number of learning processes are at play in visuomotor adaptation tasks. In addition to implicitly adapting to a perturbation, learners can develop explicit knowledge allowing them to select better actions in responding to it. Advances in visuomotor rotation experiments have underscored the important role of such "explicit learning" in shaping adaptation to kinematic perturbations. Yet, in adaptation to dynamic perturbations, its contribution has been largely overlooked. We therefore sought to approach the assessment of explicit learning in adaptation to dynamic perturbations, by developing two novel modifications of a force field experiment. First, we asked learners to abandon any cognitive strategy before selected force channel trials to expose consciously accessible parts of overall learning. Here, learners indeed reduced compensatory force compared to standard Catch channels. Second, we instructed a group of learners to mimic their right hand's adaptation by moving with their naïve left hand. While a control group displayed negligible left-hand force compensation, the mimicking group reported forces that approximated right-hand adaptation but appeared to under-report the velocity component of the force field in favor of a more position-based component. Our results highlight the viability of explicit learning as a potential contributor to force field adaptation, though the fraction of learning under participants' deliberate control on average remained considerably smaller than that of implicit learning, despite task conditions favoring explicit learning. The methods we employed provide a starting point for investigating the contribution of explicit strategies to force field adaptation.
Correlates of Blood Pressure and Cholesterol Level Testing Among a Socially-Disadvantaged Population in Poland

As part of cardiovascular disease prevention, the performance of BMI determination, blood pressure measurement, biochemical tests, as well as a lifestyle-related risk assessment are recommended. The aim of this study was to evaluate the correlates of blood pressure and cholesterol level testing among a socially-disadvantaged population in Poland. This cross-sectional study was performed between 2015 and 2016 among 1710 beneficiaries of government welfare assistance. Face-to-face interviews conducted by trained staff at each participant’s place of residence allowed for completion of questionnaires that covered socio-demographic, health and lifestyle-related information. Sixty-five percent of the participants declared a blood pressure and 27% of them cholesterol level testing at least once within the year proceeding the study. A higher chance of having blood pressure testing was observed among the women (OR = 1.5; p = 0.002) and people with high blood pressure (OR = 3.9; p < 0.001). The women (OR = 1.4; p = 0.04) and older people (OR = 1.9; p = 0.02; OR = 2.6; p < 0.001, OR = 2.7; p = 0.002, for the following age groups: 30-39, 40-49, 50-59 years respectively), the respondents who declared health problems such as heart attack (OR = 3.0; p = 0.04), high blood pressure (OR = 2.3; p < 0.001) and type 2 diabetes (OR = 3.3; p = 0.004) and those with a family history of chronic diseases (OR = 1.5; p = 0.03) had a higher chance of cholesterol level checking. Higher healthy lifestyle index, indicating that the study participants have followed almost all of the studied lifestyle-related recommendations, was a significant correlate of cholesterol level testing (OR = 1.7; p = 0.006). Actions that promote lifestyle changes, blood pressure, and cholesterol level testing should take into account the needs of the disadvantaged population and should especially target men, people with existing chronic diseases, and those with unfavorable lifestyle characteristics. With respect to the socially-disadvantaged population, the social assistance institutions and outpatient clinics are the best places to conduct activities promoting a healthy lifestyle. The most commonly applied strategies to promote lifestyle changes can cover risk assessment, increasing awareness, emotional support and encouragement, as well as a referral to specialists.
Economic evaluation of stormwater capture and its multiple benefits in California

Urban stormwater is increasingly being considered a viable alternative water supply in California and throughout the southwestern U.S. However, current economic analyses of stormwater capture do not adequately examine differences in stormwater project types and do not evaluate co-benefits provided by the projects. As a result, urban stormwater capture is undervalued as a water supply option. To advance economic analyses of stormwater capture, we determined the levelized cost of water in U.S. dollar per acre-foot of water supply (AF; 1 AF = 1233.5 m3) for 50 proposed stormwater capture projects in California, characterizing the projects by water source, process, and water supply yield. In addition, we incorporated reported co-benefits of projects into the analysis to determine the net benefit of proposed projects. Proposed urban stormwater capture projects were more expensive than non-urban stormwater capture projects on a per-volume basis ($1,180 per AF and $531 per AF, respectively); however, this was primarily driven by the relatively large size of the non-urban stormwater capture projects examined. When incorporating the limited number of reported co-benefits of the projects, the expected levelized cost of water from urban stormwater capture projects decreased dramatically. For projects that reported even a limited number of additional benefits, the net levelized cost decreased from $1,030 per AF to $150 per AF, with some of the projects demonstrating a net benefit. Thus, scaling urban stormwater capture projects to capitalize on economies of scale and incorporating co-benefits of projects can dramatically improve the economic feasibility of these projects. This work demonstrates that stormwater capture can present a cost-effective water supply option in California, and that beyond California, fairer comparisons among projects and inclusion of co-benefits can provide decision makers with adequate information to maximize investments in water management.
Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.
Neuroticism Predicts Reasoning Performance in Young but Not Older Adults

ABSTRACT Objective: This study was designed to explore age differences in the relationship of neuroticism with reasoning performance in a representative adult sample. Method: A probability sample of 242 adults (range 25–75 years; M age = 47.57 years) from the Midlife Development in the United States (MIDUS) Boston Study of Management Processes were measured on personality and cognition. Using Raven’s Progressive Matrices Test as the dependent measure of reasoning, age and neuroticism were entered as independent variables into a hierarchical regression analysis with education and basic cognitive processes (processing speed and working memory) as control variables. Results: Age (younger) and neuroticism (lower) positively predicted reasoning performance. These main effects were further qualified by an age X neuroticism interaction. Younger adults low in neuroticism performed significantly better on reasoning than those high in neuroticism, whereas the relationship of neuroticism with reasoning was not significant for the middle-aged and older adults. Conclusions: Neuroticism affects reasoning performance in young adults but not older adults. Age-related improvements in emotional regulation are suggested as a mechanism for this relationship.
DNA Methylation in Neurodegenerative and Cerebrovascular Disorders

DNA methylation is an epigenetic mechanism by which methyl groups are added to DNA, playing a crucial role in gene expression regulation. The aim of the present study is to compare methylation status of healthy subjects with that of patients with Alzheimer’s, Parkinson’s or Cerebrovascular diseases. We also analyze methylation status of a transgenic Alzheimer’s disease mouse model (3xTg-AD). Our results show that both global methylation (n = 141) and hydroxymethylation (n = 131) levels are reduced in DNA samples from buffy coats of patients with neurodegenerative disorders and age-related cerebrovascular disease. The importance of methylation and hydroxymethylation reduction is stressed by the finding that DNMT3a mRNA levels are also downregulated in buffy coats of patients with Dementia (n = 25). Global methylation is also reduced in brain, liver and serum samples of 3xTg-AD vs. wild type mice, such as DNMT3a mRNA levels that are also decreased in the brain of 3xTg-AD (n = 10). These results suggest that the use of global methylation and hydroxymethylation levels, together with the study of DNMT3a expression, could be useful as a new diagnostic biomarker for these prevalent disorders.
Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential

Non-invasive electrical stimulation (ES) is increasingly applied to improve vision in untreatable eye conditions, such as retinitis pigmentosa and age-related macular degeneration. Our previous study suggested that ES promoted retinal function and the proliferation of progenitor-like glial cells in mice with inherited photoreceptor degeneration; however, the underlying mechanism remains obscure. Müller cells (MCs) are thought to be dormant residential progenitor cells that possess a high potential for retinal neuron repair and functional plasticity. Here, we showed that ES with a ramp waveform of 20 Hz and 300 µA of current was effective at inducing mouse MC proliferation and enhancing their expression of progenitor cell markers, such as Crx (cone–rod homeobox) and Wnt7, as well as their production of trophic factors, including ciliary neurotrophic factor. RNA sequencing revealed that calcium signaling pathway activation was a key event, with a false discovery rate of 5.33 × 10−8 (p = 1.78 × 10−10) in ES-mediated gene profiling changes. Moreover, the calcium channel blocker, nifedipine, abolished the observed effects of ES on MC proliferation and progenitor cell gene induction, supporting a central role of ES-induced Ca2+ signaling in the MC changes. Our results suggest that low-current ES may present a convenient tool for manipulating MC behavior toward neuroregeneration and repair.
Staphylococcus aureus in Atopic Dermatitis: Past, Present, and Future

The role of Staphylococcus aureus (SA) in the pathogenesis and management in atopic dermatitis is rapidly evolving. The modern understanding of SA in atopic dermatitis now includes an expanded array of virulence factors, the interplay of clonal and temporal shifts in SA populations, and host factors such as filaggrin and natural moisturizing factor. New, emerging therapies that focus on long-term, targeted elimination of SA colonization are currently under investigation (Br J Dermatol 2017;17(1)63–71). Herein, we discuss and review the latest staphylococcal and microbiome-modifying therapies including topical antibiotics, topical natural oil fatty acids, anti-SA vaccines, microbial transplantation, vitamin D supplementation, dupilumab and proposed future investigative directions.
Comparison between Colposcopically Directed Biopsy and Large Loop Excision of the Transformation Zone

Objective Firstly to assess the accuracy of colposcopically directed biopsy in comparison with final diagnosis, secondly to assess correlation and agreement between colposcopically directed biopsy (CDB) and large loop excision of the transformation zone (LLETZ) Setting Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital. Study design Retrospective study. Material and Method A comparative analysis was conducted from the 234 women referred to colposcopy clinic at Ramathibodi Hospital from January 1998 to December 2006, to compare between CDB and LLETZ. Accuracy was assessed by the percentage of concordance between CDB and final diagnosis. The correlation and the agreement were assessed by Spearman’s rank correlation coefficient (r) and Kappa statistics (K). Results A 89.74 % accuracy was found between CDB and final diagnosis. The correlation and the agreement between CDB and LLETZ were low (r = 0.30, p < 0.0001; K = 0.26, p < 0.0001). The CDB had overcall and undercall rates of 19.31% and 9.87%, respectively. Conclusion Even though the correlation and agreement between CDB and LLETZ were rather low, but the accuracy was quite high. So, in our setting CDB is still of clinical use.
HIV modifies the effect of tobacco smoking on oral human papillomavirus infection.

INTRODUCTION People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We sought to investigate the joint effects of HIV and smoking on risk of oral HPV. METHODS Consecutive PLWH (n=169) and at-risk HIV-negative individuals (n=126) were recruited from two large health centers in United States. Lifetime smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping by Next-Generation Sequencing. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV and reported the Relative Excess Risk due to Interaction (RERI). RESULTS PLWH were more likely to harbor oral HPV than HIV-negative individuals, including α (39% vs. 28%), β (73% vs. 63%), and γ-types (33% vs. 20%). HIV infection positively modified the association between smoking and detection of high-risk oral HPV with odds ratios for smoking of 3.46 [95%CI:1.01, 11.94] and 1.59 [95%CI:0.32, 8.73] among PLWH and HIV-negative individuals, respectively, and an observed RERI of 3.34 [95%CI:-1.51, 8.18]. The RERI for HPV-16 was 1.79 [95%CI:-2.57, 6.16], and 2.78 for β1-HPV [95%CI:-0.08, 5.65]. CONCLUSION Our results show tobacco smoking as a risk factor for oral HPV among PLWH.
Water Ultrasound-Assisted Extraction of Polyphenol Compounds from Brewer’s Spent Grain: Kinetic Study, Extract Characterization, and Concentration

Brewer’s spent grain (BSG) was chemically characterized obtaining 52.1% of carbohydrates, 17.8% protein, 5.9% lipids, 13.5% insoluble lignin and 24.3% of water-soluble extractives. This work has been focused on the study of polyphenol extraction of the extractive fraction by water ultrasound-assisted extraction. Selected extraction conditions were 47 °C and 21.7 mL water/gdry-BSG. The effect of solvent polarity on polyphenol extraction was studied by using ethanol aqueous mixtures, from 20% to 100% ethanol. The kinetics of polyphenol extraction have been fitted to the power law and the Weibull models yielding mean values of the root mean square deviation lower than 7.5%. Extracts have been characterized in terms of quantification of individual phenolic compounds by HPLC-DAD and protein and sugar soluble fractions (glucose, xylose, and arabinose). Polyphenol profile has been compared with other hydrolytic techniques, such as acid, basic and enzymatic hydrolysis, showing that ultrasound was not as effective as basic hydrolysis to release the phenolic acids esterified to the cell wall. A further centrifuge ultrafiltration concentration step was able to yield a retentate enriched in the protein fraction while individual phenolic compounds where mainly transferred to the permeate.
Surgical Outcomes in Patients With Malignant Small Bowel Obstruction

Supplemental Digital Content is available in the text Objective: The study objectives were to characterize surgical outcomes for malignant small bowel obstruction (MaSBO) as compared to other small bowel obstructions (SBO) and to develop a prediction model for postoperative mortality for MaSBO. Summary Background Data: MaSBO is a morbid complication of advanced cancers for which the optimal management remains undefined. Methods: Patients who underwent surgery for MaSBO or SBO were identified from the National Surgical Quality Improvement Program (2005–2017). Outcomes [30-day morbidity, unplanned readmissions, mortality, postoperative length of stay (LOS)] were compared between propensity score-matched MaSBO and SBO patients. An internally validated prediction model for mortality in MaSBO patients was developed. Results: Of 46,706 patients, 1612 (3.5%) had MaSBO. Although MaSBO patients were younger than those with SBO (median 63 vs 65 years, P < 0.001), they were otherwise more clinically complex, including a higher proportion with recent weight loss (22.0% vs 4.0%, P < 0.001), severe hypoalbuminemia (18.6% vs 5.2%, P < 0.001), and cytopenias. After matching (N = 1609/group), MaSBO was associated with increased morbidity [odds ratio (OR) 1.2, P = 0.004], but not readmission (OR 1.1, P = 0.48) or LOS (incidence rate ratio 1.0, P = 0.14). The odds of mortality were significantly higher for MaSBO than SBO (OR 3.3, P < 0.001). A risk-score model predicted postoperative mortality for MaSBO with an optimism-adjusted Brier score of 0.114 and area under the curve of 0.735. Patients in the highest-risk category (11.5% of MaSBO population) had a predicted mortality rate of 39.4%. Conclusion: Surgery for MaSBO is associated with substantial morbidity and mortality, necessitating careful patient evaluation before operative intervention.
Cortical thickness and its associations with age, total cognition and education across the adult lifespan

Early-life education (years of schooling) has been investigated in regards to cognition, health outcomes and mortality. It has been shown to confer cognitive reserve that might lessen the impact of brain pathology and its impact on cognitive and motor functioning in a variety of neurodegenerative diseases and, for instance, to influence electrical activity [Begum, T. , Reza, F. , Ahmed, I. , & Abdullah, J. M. (2014). Influence of education level on design-induced N170 and P300 components of event related potentials in the human brain. J Integr Neurosci, 13(1), 71–88. doi:10.1142/S0219635214500058]. On the other hand, demonstrations of a direct association between education and brain-structural measures have been more equivocal and scant. The current study sought to identify univariate cortical-thickness patterns underlying education and general intelligence after adjusting for age, gender and possible in-scanner movement in 353 individuals aged 40 to 80. We followed up this idea with multivariate analyses as well. For univariate analyses, our analyses yielded no robust associations between education and general intelligence beyond confounding effects of gender, age and extraneous in-scanner movement. A subsequent multivariate analyses showed a relationship between education and regional cortical thickness with a robust pattern of negative as well as positive loadings in several right-sided brain areas, speaking to a subtle but robust distributed effect of education on cortical thickness. Cortical thickness variance that is the residual of this education-related pattern was shown to be positively associated with age and extraneous in-scanner movement. Our study thus presents a complex picture of the association of education with regional cortical thickness: education was associated with a distributed brain-wide pattern of positive as well as negative loadings with unaccounted residuals being larger for older participants. Focal regional associations beyond demographic and age covariates were not identified.
Mother’s Handwashing Practices and Health Outcomes of Under-Five Children in Northwest Ethiopia

Background Improving handwashing practices of mothers is important in developing countries to reduce child morbidity, mortality, and hygiene-related illnesses. This study aimed to assess mothers handwashing practice and the health effects on under-five children in northwest Ethiopia. Methods The study was an institution-based cross-sectional study conducted from November 2018 to January 2019 at the University of Gondar comprehensive specialized hospital. Four hundred and twenty two randomly selected mothers who have had under-five children were included in the study. Structured questioners were developed to assess handwashing practics and sociodemographic characterististics of mothers, and medical history related data of children were extracted from medical charts. Data entry and clearance were performed by Epi-infoTM version-7 software and exported for analysis to SPSS 22. Adjusted odds ratio with a 95% confidence interval was used to declare statistically significant variables on the basis of p-value < 0.05. Results The proportion of mothers who practiced good handwashing was 39.1% [95% CI: (34.8–43.9)]. More than half (54.3% and 53.6%) of the mothers indicated that they always remind their children to wash their hands before and after eating, respectively. However, 28% of under-five children were admitted to hospital with a diarrheal disease which may have been due to the poor hand washing practices of their mother. The odds of having good knowledge of handwashing practices were 0.26 times lower. Being married increased the handwashing practices of mothers by 2.62 times. Conclusion The majority of mothers who were knowledgable about handwashing were not executing it accuractely. Diarrheal admissions among under-five children have been influenced by their mother's poor hand washing practices. Therefore, it is imperitive to improve the understanding of proper handwashing practices of mothers at every level in the community.
Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma

Risk factors including genetic effects are still being investigated in lung adenocarcinoma (LUAD). Mitochondria play an important role in controlling imperative cellular parameters, and anomalies in mitochondrial function might be crucial for cancer development. The mitochondrial genomic aberrations found in lung adenocarcinoma and their associations with cancer development and progression are not yet clearly characterized. Here, we identified a spectrum of mitochondrial genome mutations in early-stage lung adenocarcinoma and explored their association with prognosis and clinical outcomes. Next-generation sequencing was used to reveal the mitochondrial genomes of tumor and conditionally normal adjacent tissues from 61 Stage 1 LUADs. Mitochondrial somatic mutations and clinical outcomes including relapse-free survival (RFS) were analyzed. Patients with somatic mutations in the D-loop region had longer RFS (adjusted hazard ratio, adjHR = 0.18, p = 0.027), whereas somatic mutations in mitochondrial Complex IV and Complex V genes were associated with shorter RFS (adjHR = 3.69, p = 0.012, and adjHR = 6.63, p = 0.002, respectively). The risk scores derived from mitochondrial somatic mutations were predictive of RFS (adjHR = 9.10, 95%CI: 2.93–28.32, p < 0.001). Our findings demonstrated the vulnerability of the mitochondrial genome to mutations and the potential prediction ability of somatic mutations. This research may contribute to improving molecular guidance for patient treatment in precision medicine.