Miracle-dz/UniFAR-FTUs huggingface dataset:
Onset of Giant Planet Migration before 4480 Million Years Ago

Soon after their formation, the terrestrial planets experienced intense impact bombardment by comets, leftover planetesimals from primary accretion, and asteroids. This temporal interval in solar system evolution, termed late accretion, thermally and chemically modified solid planetary surfaces and may have impeded life's emergence on the Hadean (pre-3850 Ma) Earth. The sources and tempo of bombardment, however, remain obscure. Here we present a timeline that relates variably retentive radiometric ages documented from asteroidal meteorites to new dynamical models that invoke an early episode of planetesimal-driven giant planet migration after the dispersal of the protoplanetary disk. Reconciliation of geochronological data with dynamical models shows that such giant planet migration should lead to an intense ∼30 Myr influx of comets to the entire solar system manifested in radiometric age data. The absence of wholesale crustal reset ages after ∼4450 Ma for the most resilient chronometers from Earth, Moon, Mars, 4 Vesta, and various meteorite parent bodies confines the onset of giant planet migration to ca. 4480 Ma. Waning impacts continue to strike the inner planets through a protracted monotonic decline in impactor flux, in agreement with predictions from crater chronology. New global 3D thermal analytical bombardment models derived from our revised impact mass-production functions show also that persistent niches for prebiotic chemistry leading to the emergence of life on the early Hadean Earth could endure late accretion since at least about 4400 million years ago.
Binary Oxides Prepared by Microwave-Assisted Solution Combustion: Synthesis, Characterization and Catalytic Activity

Three different alumina-based Ni, Cu, Co oxide catalysts with metal loading of 10 wt %, and labeled 10Ni–Al, 10Co–Al and 10Cu–Al, were prepared by microwave-assisted solution combustion. Their morphological, structural and surface properties were deeply investigated by complementary physico-chemical techniques. Finally, the three materials were tested in CO oxidation used as test reaction for comparing their catalytic performance. The 10Cu–Al catalyst was constituted of copper oxide phase, while the 10Ni–Al and 10Co–Al catalysts showed the presence of “spinels” phases on the surface. The well-crystallized copper oxide phase in the 10Cu–Al catalyst, obtained by microwave synthesis, allowed for obtaining very high catalytic activity. With a CO conversion of 100% at 225 °C, the copper containing catalyst showed a much higher activity than that usually measured for catalytic materials of similar composition, thus representing a promising alternative for oxidation processes.
Living with multimorbidity? The lived experience of multiple chronic conditions in later life

Multimorbidity is defined biomedically as the co-existence of two or more long-term conditions in an individual. Globally, the number of people living with multiple conditions is increasing, posing stark challenges both to the clinical management of patients and the organisation of health systems. Qualitative literature has begun to address how concurrency affects the self-management of chronic conditions, and the concept of illness prioritisation predominates. In this article, we adopt a phenomenological lens to show how older people with multiple conditions experience illness. This UK study was qualitative and longitudinal in design. Sampling was purposive and drew upon an existing cohort study. In total, 15 older people living with multiple conditions took part in 27 in-depth interviews. The practical stages of analysis were guided by Constructivist Grounded Theory. We argue that the concept of multimorbidity as biomedically imagined has limited relevance to lived experience, while concurrency may also be erroneous. In response, we outline a lived experience of multiple chronic conditions in later life, which highlights differences between clinical and lay assumptions and makes the latter visible.
Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis

Supplemental digital content is available in the text. Introduction The value of antineutrophil cytoplasmic antibody (ANCA) measurements among patients with an established diagnosis of ANCA-associated vasculitis (AAV) to assess disease activity or predict relapse remains controversial, but recent evidence suggests a possible role for rituximab-treated patients. Patients and Methods All patients with active vasculitis and positive proteinase 3 (PR3)–ANCA who were starting a 2-year treatment course of rituximab for induction of remission at Addenbrooke's Hospital between January 2011 and January 2016 were included in this study. Common department practice consists of 6 g of rituximab given over 2 years, concomitant corticosteroids (0.5–1.0 mg/kg) with rapid taper over 3 months, and cessation of oral maintenance immunosuppressive agents at time of first rituximab dose. Clinical and laboratory data were collected retrospectively using electronic patient records. Results Fifty-seven patients with current PR3-ANCA positivity were included in the analysis. Median follow-up was 59 months. PR3-ANCA negativity was achieved in 25 patients (44%) with a median time of 14 months. Clinical remission was achieved in 53 patients (93%) with a median time of 3 months. Among the 53 patients who achieved remission during follow-up, 24 (45%) relapsed with a median time to relapse of 36 months from remission. Both PR3-ANCA–negative status and 50% reduction in PR3-ANCA from baseline (as time-varying covariates) were significantly associated with a longer time to relapse (PR3-ANCA–negative status: hazards ratio, 0.08 [95% confidence interval, 0.01–0.63, p = 0.016]; 50% reduction in PR3-ANCA: hazards ratio, 0.25 [95% confidence interval, 0.18–0.99, p = 0.046]). Conclusions Achieving and maintaining PR3-ANCA negativity after rituximab was associated with longer-lasting remission.
External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort

ABSTRACT Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
Quot schemes of curves and surfaces: virtual classes, integrals, Euler characteristics

We compute tautological integrals over Quot schemes on curves and surfaces. After obtaining several explicit formulas over Quot schemes of dimension 0 quotients on curves (and finding a new symmetry), we apply the results to tautological integrals against the virtual fundamental classes of Quot schemes of dimension 0 and 1 quotients on surfaces (using also universality, torus localization, and cosection localization). The virtual Euler characteristics of Quot schemes of surfaces, a new theory parallel to the Vafa-Witten Euler characteristics of the moduli of bundles, is defined and studied. Complete formulas for the virtual Euler characteristics are found in the case of dimension 0 quotients on surfaces. Dimension 1 quotients are studied on K3 surfaces and surfaces of general type with connections to the Kawai-Yoshioka formula and the Seiberg-Witten invariants respectively. The dimension 1 theory is completely solved for minimal surfaces of general type admitting a nonsingular canonical curve. Along the way, we find a new connection between weighted tree counting and multivariate Fuss-Catalan numbers which is of independent interest.
Associations Between Lifetime Traumatic Experiences and HIV-Risk Behaviors Among Young Men Living in Informal Settlements in South Africa: A Cross-Sectional Analysis and Structural Equation Model

Background: Qualitative research emphasizes men's experiences of trauma increase HIV risk. We seek to understand associations between experience of traumatic events and HIV-risk behaviors among heterosexual men in 2 trials in urban informal settlements in South Africa. Methods: Cross-sectional surveys among men in Johannesburg and Durban, South Africa, enrolled in intervention trials. Adjusted logistic regression and structural equation modeling assessed associations between men's experiences of poverty and traumatic events, and HIV-risk behaviors (inconsistent condom use, transactional sex, and number of sex partners). We explored mediated pathways from trauma to HIV risk through mental health and alcohol, and gender attitudes. Results: Among 2394 men, in adjusted logistic regression, transactional sex and 4 or more sex partners were associated with witnessing the murder of a family member, witnessing a murder of a stranger, experiencing excessive pain, been kidnapped, and witnessing a rape. More consistent condom use was associated with witnessing the murder of a family member, being kidnapped, and witnessing a rape. In 3 separate structural equation modeling pathways were consistent, trauma directly increased transactional sex, and past year sexual partners, and increased consistent condom use. Risk was increased through mental health pathways, and gender inequitable attitudes and practices. Conclusion: Men's HIV-risk behaviors in this population emerge at the confluence of poverty, traumatic experiences, and gender inequalities. Effective HIV-prevention interventions needs to reduce men's experiences of poverty and trauma, transform gender norms, and reduce the mental health impact of trauma.
Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion

Skeletal muscle development requires the cell–cell fusion of differentiated myoblasts to form muscle fibers. The actin cytoskeleton is known to be the main driving force for myoblast fusion; however, how actin is organized to direct intercellular fusion remains unclear. Here we show that an actin- and dynamin-2–enriched protrusive structure, the invadosome, is required for the fusion process of myogenesis. Upon differentiation, myoblasts acquire the ability to form invadosomes through isoform switching of a critical invadosome scaffold protein, Tks5. Tks5 directly interacts with and recruits dynamin-2 to the invadosome and regulates its assembly around actin filaments to strengthen the stiffness of dynamin-actin bundles and invadosomes. These findings provide a mechanistic framework for the acquisition of myogenic fusion machinery during myogenesis and reveal a novel structural function for Tks5 and dynamin-2 in organizing actin filaments in the invadosome to drive membrane fusion.
Dual Residual Networks Leveraging the Potential of Paired Operations for Image Restoration

In this paper, we study design of deep neural networks for tasks of image restoration. We propose a novel style of residual connections dubbed "dual residual connection", which exploits the potential of paired operations, e.g., up- and down-sampling or convolution with large- and small-size kernels. We design a modular block implementing this connection style; it is equipped with two containers to which arbitrary paired operations are inserted. Adopting the "unraveled" view of the residual networks proposed by Veit et al., we point out that a stack of the proposed modular blocks allows the first operation in a block interact with the second operation in any subsequent blocks. Specifying the two operations in each of the stacked blocks, we build a complete network for each individual task of image restoration. We experimentally evaluate the proposed approach on five image restoration tasks using nine datasets. The results show that the proposed networks with properly chosen paired operations outperform previous methods on almost all of the tasks and datasets.
Super‐recognizers: From the lab to the world and back again

The recent discovery of individuals with superior face processing ability has sparked considerable interest amongst cognitive scientists and practitioners alike. These ‘Super‐recognizers’ (SRs) offer clues to the underlying processes responsible for high levels of face processing ability. It has been claimed that they can help make societies safer and fairer by improving accuracy of facial identity processing in real‐world tasks, for example when identifying suspects from Closed Circuit Television or performing security‐critical identity verification tasks. Here, we argue that the current understanding of superior face processing does not justify widespread interest in SR deployment: There are relatively few studies of SRs and no evidence that high accuracy on laboratory‐based tests translates directly to operational deployment. Using simulated data, we show that modest accuracy benefits can be expected from deploying SRs on the basis of ideally calibrated laboratory tests. Attaining more substantial benefits will require greater levels of communication and collaboration between psychologists and practitioners. We propose that translational and reverse‐translational approaches to knowledge development are critical to advance current understanding and to enable optimal deployment of SRs in society. Finally, we outline knowledge gaps that this approach can help address.
Right Heart Catheterization During Exercise in Patients with COPD—An Overview of Clinical Results and Methodological Aspects

Abstract While right heart catheterization (RHC) at rest is the gold standard to assess pulmonary hemodynamics in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), the invasive measurement of exercise hemodynamics is less well established in this group. Since exercise hemodynamics are increasingly recognized as important clinical information in patients with PH, our goal was to review the literature in this field to provide a basis for clinical use, further studies, and future recommendations. We identified 69 studies (published since 1968) reporting RHC data in 2819 patients with COPD, of whom 2561 underwent exercise testing. Few studies simultaneously measured gas exchange during exercise. Overall, these studies showed large variations in the patient populations and research questions studied and the methods and definitions employed. Despite these limitations, the data consistently demonstrated the presence of precapillary PH at rest in up to 38% of patients with COPD. With exercise, a relevant proportion of patients developed an abnormal hemodynamic response, depending on the definition used. Furthermore, some studies assessed right ventricular function during exercise and showed a blunted increase in right ventricular ejection fraction. Drug effects and the impact of interventional procedures were also studied. Again, due to large variations in the patients studied and the methods used, firm conclusions are difficult to derive. Despite the limitations of this dataset, several recommendations with respect to technical aspects (body position, exercise protocol, and data acquisition) can be inferred for this challenging patient population and may be helpful for further studies or recommendations.
On the Gravitational Force on Anti‐Matter

A number of experiments are currently underway on antimatter, particularly anti‐hydrogen, to test whether the fundamental interactions behave the same way as for matter. Here we present a simple argument showing that a bound on a difference in gravitational forces exerted on matter and antimatter is already so severe that is goes well beyond the sensitivity of the above measurements.
Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions

While much is known about acute infection pathogenesis, the understanding of chronic infections has lagged. Here we sought to identify the genes and functions that mediate fitness of the pathogen Pseudomonas aeruginosa in chronic wound infections, and to better understand the selective environment in wounds. We found that clinical isolates from chronic human wounds were frequently defective in virulence functions and biofilm formation, and that many virulence and biofilm formation genes were not required for bacterial fitness in experimental mouse wounds. In contrast, genes involved in anaerobic growth, some metabolic and energy pathways, and membrane integrity were critical. Consistent with these findings, the fitness characteristics of some wound impaired-mutants could be represented by anaerobic, oxidative, and membrane-stress conditions ex vivo, and more comprehensively by high-density bacterial growth conditions, in the absence of a host. These data shed light on the bacterial functions needed in chronic wound infections, the nature of stresses applied to bacteria at chronic infection sites, and suggest therapeutic targets that might compromise wound infection pathogenesis.
Perceived Needs of The Family Caregivers of People with Dementia in a Mediterranean Setting: A Qualitative Study

The purpose of this study was to identify, classify and analyze the perceived needs of caregivers of elderly people with dementia during the care process. A descriptive phenomenological qualitative study using seven focus groups was conducted in different primary health care centers in the province of Jaén (Spain) between July 2012 and February 2013. Eighty-two family caregivers who were caring for people with dementia in different stages of the disease were selected by purposeful maximum variation sampling. Data were analyzed and organized thematically, considering the semantic and pragmatic content and field notes. Two main categories of the perceived needs of caregivers were identified. The first was related to the management of caring for a relative with dementia, and the second was related to the management of the caregivers’ own care. Our findings support the provision of comprehensive interventions for the improvement of caregivers’ emotional health that encompass more than one care need. This is where psycho-educational interventions aimed at managing the various aspects of dementia and self-care in caregivers can be accommodated. In addition, proactive interventions to develop important skills to care for a relative with dementia, which are not perceived as needs by the caregivers, are needed. These include skills in family negotiation, planning and searching for resources outside the family.
Power-Related Determinants of Modified Agility T-test Performance in Male Adolescent Basketball Players

Abstract Scanlan, AT, Wen, N, Pyne, DB, Stojanović, E, Milanović, Z, Conte, D, Vaquera, A, and Dalbo, VJ. Power-related determinants of Modified Agility T-test performance in male adolescent basketball players. J Strength Cond Res 35(8): 2248–2254, 2021—Although the Modified Agility T-test (MAT) has been advocated for assessing change-of-direction performance in basketball, the power-related attributes emphasized during the test are unknown. Therefore, the aim of this study was to identify the power-related determinants of the MAT in basketball players. A cross-sectional, descriptive research design was used whereby national- and state-level male adolescent basketball players (n = 24; 17.3 ± 0.5 years) completed a battery of power-related performance tests. The tests administered included the MAT, isometric midthigh pull, 10-m sprint, countermovement jump, 1-step vertical jump, standing long jump, and repeated lateral bound. Associations between performance during the MAT and other tests were quantified, and performance in each test was compared between faster (>50th percentile) and slower (<50th percentile) players in the MAT. The MAT exhibited large correlations (p < 0.05) with standing long jump distance (r = −0.67, R2 = 45%), countermovement jump relative peak force (r = −0.63, R2 = 39%), isometric midthigh pull relative peak force (r = −0.55, R2 = 30%), and 10-m sprint time (r = 0.53, R2 = 28%). The faster group performed better (p < 0.05) during the standing long jump (mean difference; ±90% confidence limits: 0.16; ±0.12 m) and produced greater (p < 0.05) relative peak force during the isometric midthigh pull (2.5; ±2.3 N·kg−1) and countermovement jump (2.1; ±1.8 N·kg−1) than the slower group. The MAT complements other power-related tests used in basketball and stresses basketball-specific, power-related attributes in various movement planes. These data can inform training and testing approaches to optimize change-of-direction performance in basketball.
Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity

The ability to detect changes in nutrient levels and generate an adequate response to these changes is essential for the proper functioning of living organisms. Adaptation to the high degree of variability in nutrient intake requires precise control of metabolic pathways. Mammals have developed different mechanisms to detect the abundance of nutrients such as sugars, lipids and amino acids and provide an integrated response. These mechanisms include the control of gene expression (from transcription to translation). This review reports the main molecular mechanisms that connect nutrients’ levels, gene expression and metabolism in health. The manuscript is focused on sugars’ signaling through the carbohydrate-responsive element binding protein (ChREBP), the role of peroxisome proliferator-activated receptors (PPARs) in the response to fat and GCN2/activating transcription factor 4 (ATF4) and mTORC1 pathways that sense amino acid concentrations. Frequently, alterations in these pathways underlie the onset of several metabolic pathologies such as obesity, insulin resistance, type 2 diabetes, cardiovascular diseases or cancer. In this context, the complete understanding of these mechanisms may improve our knowledge of metabolic diseases and may offer new therapeutic approaches based on nutritional interventions and individual genetic makeup.
Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa

Hypoxia, a potent activator of the sympathetic nervous system, is known to increase muscle sympathetic nerve activity (MSNA) to the peripheral vasculature of native Lowlanders during sustained high altitude (HA) exposure. We show that the arterial baroreflex control of MSNA functions normally in healthy Lowlanders at HA, and that upward baroreflex resetting permits chronic activation of basal sympathetic vasomotor activity under this condition. The baroreflex MSNA operating point and resting sympathetic vasomotor outflow both are lower for highland Sherpa compared to acclimatizing Lowlanders; these lower levels may represent beneficial hypoxic adaptation in Sherpa. Acute hyperoxia at HA had minimal effect on baroreflex control of MSNA in Lowlanders and Sherpa, raising the possibility that mechanisms other than peripheral chemoreflex activation contribute to vascular sympathetic baroreflex resetting and sympathoexcitation. These findings provide a better understanding of sympathetic nervous system activation and the control of blood pressure during the physiological stress of sustained HA hypoxia.