Miracle-dz/UniFAR-FTUs huggingface dataset:
Transformative Leadership to Enhance the Quality of Madrasa in the Covid-19 Outbreak: Learning Organization Perspective

This study aims to identify the implementation of transformative leadership in a madrasa in East Java. It was based on Peter Senge's learning organization theory. Moreover, this study employed quantitative descriptive research using the online survey method. It involved the leaders and the teachers of madrasa in East Java. The data was taken from February to April 2021. The respondents were 90 leaders and the teachers of all levels of madrasa – MI, MTs, and MA. It used random sampling. The researcher gathered the data from the questionnaires through Google Forms. Then, the data were analyzed descriptively. Based on Peter Senge's five-learning organization, transformative leadership implementation was found in madrasa during the Covid-19 outbreak. First, the systems thinking of teachers and education staff in madrasa during the outbreak had two indicators. The transformation of the madrasa service system based on some considerations is 75%. The curriculum adjustment also is 79%. Second, the implementation of personal mastery was through two indicators – learning new things and facing the challenges is 78%, and relevant learning method innovation is 81%. Third, the mental model is based on two indicators. They are the thinking skills quality improvement for better competence is 78% and improving the school system focused on the service quality is 83%. Fourth is the implementation of a shared vision which is based on two indicators. 79% of schools' communities comprehend the school vision. It also shows that the task completion based on the school vision is 86%. Fifth, team learning is based on two indicators. The peer group sharing habit is 90%, and fostering a dialogue culture with the leaders to improve school quality is 87%. In conclusion, this study shows that the implementation of transformative leadership enhances the madrasas’ quality amidst the covid-19 based on a learning organization perspective.
Country-level determinants, takeover locations, and the gains to target firms

This study enhances the understanding of imperfect factor markets by examining the impact of country-level factors on takeover location decisions and the gains to target firms. The focus of this study is on eight East and Southeast Asian countries, where there have been significant changes regarding corporate governance structures and practices following the 1997-1998 Asian financial crisis. The results suggest that the likelihood that a completed deal is a cross-border acquisition rather than a domestic acquisition is higher for target countries with lower government quality, weaker investor protection, stronger restrictions on capital mobility, lower corporate tax rates, and more depreciated currencies. Further, the study documents that target firm shareholders experience positive and significant abnormal returns in both cross-border and domestic acquisitions around the announcement date; but cross-border target firms gain significantly higher returns than domestic target firms.
Beyond Keypoint Coding: Temporal Evolution Inference with Compact Feature Representation for Talking Face Video Compression

We propose a talking face video compression framework by implicitly transforming the temporal evolution into compact feature representation. More specifically, the temporal evolution of faces, which is complex, non-linear and difficult to extrapolate, is modelled in an end-to-end inference framework based upon very compact features. This enables the high-quality rendering of the face videos, which benefits from the learning of dense motion map with compact feature representation. Therefore, the proposed framework can accommodate ultra-low bandwidth video communication and maintain the quality of the reconstructed videos. Experimental results demonstrate that compared with the state-of-the-art video coding standard Versatile Video Coding (VVC) as well as the latest generative compression scheme Face Video-to-Video Synthesis (Face_vid2vid), the proposed scheme is superior in terms of both objective and subjective quality assessment methods.
Thirty Years of sRNA-Mediated Regulation in Staphylococcus aureus: From Initial Discoveries to In Vivo Biological Implications

Staphylococcus aureus is a widespread livestock and human pathogen that colonizes diverse microenvironments within its host. Its adaptation to the environmental conditions encountered within humans relies on coordinated gene expression. This requires a sophisticated regulatory network, among which regulatory RNAs (usually called sRNAs) have emerged as key players over the last 30 years. In S. aureus, sRNAs regulate target genes at the post-transcriptional level through base–pair interactions. The functional characterization of a subset revealed that they participate in all biological processes, including virulence, metabolic adaptation, and antibiotic resistance. In this review, we report 30 years of S. aureus sRNA studies, from their discovery to the in-depth characterizations of some of them. We also discuss their actual in vivo contribution, which is still lagging behind, and their place within the complex regulatory network. These shall be key aspects to consider in order to clearly uncover their in vivo biological functions.
Excessive risk and poor outcome of hospital-acquired peritoneal dialysis-related peritonitis

ABSTRACT Background Peritoneal dialysis (PD) is a home-based renal replacement therapy. Since hospital staff are not often familiar with PD and its complications, PD patients may have an excess risk of developing PD-related peritonitis during hospital admission for unrelated reasons, and the outcome may be affected. Methods We reviewed 371 episodes of hospital-acquired PD peritonitis in our center from 2000 to 2019. Their clinical characteristics and outcomes were compared with 825 episodes that required hospital admission and 1964 episodes that were treated as outpatient. Results Hospitalized PD patients had a significantly higher risk of developing peritonitis than outpatients [incident rate ratio 4.41 (95% confidence interval 3.95–4.91]. Hospital-acquired peritonitis episodes were more commonly culture negative. Bacterial isolates from the hospital-acquired episodes were more likely resistant to ceftazidime (P < .0001) than the other groups. The primary response rate, complete cure rate and overall mortality of the hospital-acquired episodes were 66.6%, 62.0%, and 23.2%, respectively, all worse than episodes that developed outside the hospital (P < .0001 for all). Conclusion PD patients admitted to the hospital had a 4-fold increase in the risk of developing peritonitis. Hospital-acquired peritonitis episodes were more likely culture negative and resistant to antibiotics. They also had a lower primary response rate, a lower complete cure rate and higher mortality than episodes that developed outside the hospital.
There's an app for that, but nobody's using it: Insights on improving patient access and adherence to digital therapeutics in Germany

Background Mobile health applications and their subset digital therapeutics—defined as evidence-based software interventions to prevent, manage, or treat a medical condition—offer great potential to improve patient care. However, such solutions often struggle to reach widespread adoption. Objective This study seeks to explore healthcare stakeholders’ roles and potential for fostering patient access and adherence to evidence-based digital therapeutics and thereby improve health outcomes from the perspective of digital therapeutics developers and distributors. Methods Semi-structured qualitative and semiquantitative interviews were conducted with 19 experts from developers and distributors of digital therapeutics in Germany to discuss their perceived relevance of different healthcare stakeholders and strategies in promoting patient access and adherence to digital therapeutics. Results Healthcare professionals were found to have the greatest potential to promote both access and patient adherence to digital therapeutics, followed by health insurers, pharmaceutical companies, and patients themselves. In terms of patient access, healthcare professionals have potential due to their ability to prescribe digital therapeutics. Other stakeholders’ potential stems from their capacity to influence healthcare professionals prescription decision. In terms of patient adherence, only healthcare professionals are of high relevance by onboarding patients and monitoring digital therapeutics use. Most healthcare stakeholders currently do not fully leverage their potential. Further educating healthcare professionals and simplifying processes for them, empowering patients to seek treatment with digital therapeutics, and designing digital therapeutics’ product features for better adherence can help improve patient access and adherence. Conclusions Established healthcare stakeholders and digital therapeutics developers both need to take action to improve patient access and adherence to digital therapeutics. Several macro-level changes can support these efforts, including broader information dissemination, improved financial incentives, simplified prescription and activation processes, and a wider adoption of blended care and pay-for-performance payment models.
Alteration of testosterone: cortisol ratio induced by resistance training in women

The ratio between the concentration of testosterone and cortisol (T:C) is frequently used as indicative of the stress level imposed by the exercise. Alterations in the concentration of these hormones are responsible for modulating several responses induced by training, such as hypertrophy and strength gain. The objective of the present study was to investigate the influence of the resistance training protocol, also known as multiple-series (MS), on the strength gain, the muscular endurance and the relation between the concentration of catabolic hormones (cortisol) and anabolic hormones (testosterone). In order to test this hypothesis, five young women with one-year of strength training practice were submitted to the MS protocol. The blood samples were collected before and immediately after the exercise at the first day and after eight weeks of training. The 1-RM and the maximal repetition tests were also performed at the beginning and after eight weeks of strength training. No alterations on the body mass, on the IMC, on the fat mass percentage and on the maximal strength (1-RM) on bench press, squat and arm curl were observed. The number of maximal repetitions at 50% of the 1-RM was increased only for the bench press (p < 0.05). No alterations on the concentration of the total testosterone were observed. The cortisol plasmatic concentration, after eight weeks of training, in the rest situation, was reduced (38%; p < 0.05). Due to the lessening of the cortisol secretion after eight weeks of training, the T:C ratio presented elevation of 20% in the rest situation (p < 0.05). Although no functional alterations in the 1-RM and maximal repetitions tests were detected, the MS method induced a hormonal condition favorable to the protein metabolism.
Hyperelliptic Covers of Different Degree for Elliptic Curves

In elliptic curve cryptography (ECC) and hyperelliptic curve cryptography (HECC), the size of cipher-text space defined by the cardinality of Jacobian is a significant factor to measure the security level. Counting problems on Jacobians of elliptic curve can be solved in polynomial time by Schoof–Elkies–Atkin (SEA) algorithm. However, counting problems on Jacobians of hyperelliptic curves are solved less satisfactorily than those on elliptic curves. So, we consider the construction of the cover map from the hyperelliptic curves to the elliptic curves to convert point counting problems on hyperelliptic curves to those on elliptic curves. We can also use the cover map as a kind of cover attacks. Given an elliptic curve over an extension field of degree n , one might try to use the cover attack to reduce the discrete logarithm problem (DLP) in the group of rational points of the elliptic curve to DLPs in the Jacobian of a curve of genus g ≥ n over the base field. An algorithm has been proposed for finding genus 3 hyperelliptic covers as a cover attack for elliptic curves with cofactor 2. Our algorithms are about the cover map from hyperelliptic curves of genus 2 to elliptic curves of prime order. As an application, an example of an elliptic curve whose order is a 256-bit prime vulnerable to our algorithms is given.
Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats

Acute kidney injury (AKI), formly known as acute renal failure (ARF), is an abrupt and reversible decrease in kidney function as indicated by the glomerular filtration rate (GFR). Diclofenac-induced AKI is due to toxic effect of it on renal glomeruli, resulting in glomerular lesions. Furthermore, diclofenac causes autolysis, which increase renal intracellular osmolarity that leads to proximal renal tubular dilatations. Lipoic acid (LA) has antioxidant and anti-inflammatory activities. Bosentan is a competitive endothelin A (ETA) and endothelin B (ETB) receptors antagonist. In this study, the evaluation of effectiveness of lipoic acid and bosentan against diclofenac-induced AKI was done by histopathological examination. The results showed that diclofenac caused histopathological changes include; retracted glomerulus, tubular cast, tubule-interstitial inflammation and tubular necrosis. Lipoic acid or bosentan alone could not reduce the histopathological alterations caused by diclofenac. Meanwhile, the combination therapy was able to reduce the histopathological changes significantly (p>0.05). Therefore, the combination therapy of lipoic acid and bosentan showed promising ameliorative effect against diclofenac-induced AKI
Tillering of two wheat genotypes as affected by phosphorus levels - doi: 10.4025/actasciagron.v34i3.13326

Tillering plays an important role in wheat yield potential and it is affected by genotype and environmental conditions. This work aimed to study the effects of phosphorus levels on tiller emergence, survival and contribution to yield potential of two wheat cultivars. The experiment was carried out under greenhouse conditions in Botucatu, Sao Paulo State, Brazil. A 2 x 5 factorial randomized block design with four replications was applied. Two wheat cultivars (IAC 370 and IAC 375) and five phosphorus levels (0, 150, 300, 450 and 600 mg dm-3) were evaluated in pots with 10 dm3 of a clayey Oxisol. Higher P levels increased tiller emergence, survival and yield, especially for secondary tillers. Tiller abortion levels were higher in IAC 370 cultivar whereas retention of formed tillers was higher in IAC 375.
Analyzing BMP2, FGFR, and TGF Beta Expressions in High-Grade Osteosarcoma Untreated and Treated Autografts Using Proteomic Analysis

In the last few decades, biological reconstruction techniques have improved greatly for treating high-grade osteosarcoma patients. To conserve the limb, and its function the affected tumor-bearing bones have been treated using liquid nitrogen and irradiation processes that enable the removal of entire tumors from the bone, and these treated autografts can be reconstructed for the patients. Here, we focus on the expressions of the growth factor family proteins from the untreated and treated autografts that play a crucial role in bone union, remodeling, and regeneration. In this proteomic study, we identify several important cytoskeletal, transcriptional, and growth factor family proteins that showed substantially low levels in untreated autografts. Interestingly, these protein expressions were elevated after treating the tumor-bearing bones using liquid nitrogen and irradiation. Therefore, from our preliminary findings, we chose to determine the expressions of BMP2, TGF-Beta, and FGFR proteins by the target proteomics approach. Using a newly recruited validation set, we successfully validate the expressions of the selected proteins. Furthermore, the increased growth factor protein expression after treatment with liquid nitrogen may contribute to bone regeneration healing, assist in faster recovery, and reduce local recurrence and metastatic spread in high-grade sarcoma patients.
Intramucosal Calprotectin Expression in Inflammatory Bowel Disease (IBD) and Non-IBD Colorectal Inflammation

BACKGROUND: Inflammatory bowel disease (IBD) diagnosis remains a challenge accompanied with high numbers of misdiagnosis causing suboptimal management. Tons of trials have been conducted to improve the diagnostic accuracy, one of which is the use of biomarker such as calprotectin. Calprotectin can be detected in tissue (intramucosal) and is becoming a potential marker of IBD. AIM: This study aims to determine intramucosal calprotectin expression in IBD, non-IBD colitis, and control. METHODS: This analytic retrospective study included consecutively sampled IBD and non-IBD colitis colorectal biopsy specimens, and control group obtained from Cipto Mangunkusumo Hospital registered from 2017 to 2019. Cases were included in the study if specimens were indicative of IBD and non-IBD clinically and histopathologically and no abnormality were found histopathologically in the control group. Specimens with non-adequate data from the hospital medical records or with missing tissue slides were excluded from the study. Calprotectin immunostaining was conducted to evaluate mean intramucosal calprotectin expression (cell/HPF) in each group. RESULTS: Most of the samples from IBD and non-IBD group (45 samples each) showed mild active inflammation. Mucosal calprotectin expression in aforementioned groups was higher than that of control group (p < 0.001). Subjects with active inflammation showed higher calprotectin expression compared to those with inactive inflammation (p < 0.001). Calprotectin expression was also related to activity grade. CONCLUSION: Higher calprotectin expression showed significant association with the presence of inflammation and disease activity. However, the application of intramucosal calprotectin immunohistochemistry test to determine inflammatory etiology (IBD vs. non-IBD) still needs to be further evaluated.
The Intervention Service Coverage on Convergence Action to Reduce Stunting in Riau Province Priority Districts, Indonesia

BACKGROUND: The prevalence of stunting in Riau, Indonesia based on the Indonesian Toddler Nutrition Status Survey in 2019 was 23.95%. Efforts to reduce the prevalence of stunting remain challenging to achieve the target of 18% by 2024. One of the pillars in efforts to reduce stunting is convergence action involving multi-stakeholders to ensure the service delivery interventions received by targeted 1000 days of early life households. OBJECTIVE: This study objective was to describe the intervention service coverage on stunting convergence action to reduce stunting in Riau Province, Indonesia. METHODS: The intervention service coverage was obtained from web monitoring convergence Action and Reporting System in 2020 and nutritional status was from the Electronic Community-Based Nutrition Recording. Data was taken from 10 priority districts. There were 11 specific interventions and 9 sensitive interventions were analyzed. The data were analysed descriptively by districts and type of intervention. RESULTS: The specific and sensitive interventions implemented in 161 priority villages in 2021.The results of the study were 6.0% of 392,444 under-five aged children indicated stunting. The average coverage of specific interventions was 78.3% and sensitive intervention was 50.3%. In specific intervention, supplementary feeding for wasted child (92.4%) and chronic energy deficiency pregnant women (91.1%) were the only indicator that reached the set target. All sensitive intervention were not reached the target. Rokan Hulu (89.5%), Pekanbaru (88.0%), Kampar (84.4%), Pelawan (82.6%) districts had a high specific intervention. The highest sensitive intervention was in Rokan Hulu (74.6%). The budget from regional development for specific intervention was 28.2% and sensitive intervention was 71.8%. CONCLUSION: The coverage service of sensitive intervention was lower than specific intervention. Only 2 out of 11 specific interventions coverage had reach the target and all of sensitive intervention coverage had not reach the target. The specific and sensitive intervention coverage was varied among priority district. The strengthening of interventions is required to increase coverage service delivery to the targeted household. The local government convergence action and increasing the role of the village authorities were the main keys in accelerating stunting reduction.
Predicting Climate Change Impacts on the Rare and Endangered Horsfieldia tetratepala in China

Global climate change has become a major threat to biodiversity, posing severe challenges to species conservation. This is particularly true for species such as Horsfieldia tetratepala that have extremely small populations in the wild. Little is known about the species distribution of H. tetratepala in the current climate, as well as how that will change with potential future climates. The key environmental factors that influence its expansion, especially its habitat sustainability and its potential to adapt to climate change, are also unknown, though such information is vital for the protection of this endangered species. Based on six climate factors and 25 species distribution points, this study used the maximum entropy model (MaxEnt) to simulate the potential distribution for H. tetratepala in three periods (current, 2050s, and 2070s), and to investigate the changes in distribution patterns and the main environmental factors affecting species distribution. The modeling results show that the most important bioclimatic variables affecting H. tetratepala were precipitation of the warmest quarter (Bio_18) and temperature seasonality (Bio_4). The suitable areas for H. tetratepala will gradually be lost in Yunnan but will be generally offset in the northeastward direction, expanding in Hainan, Guangzhou, and Taiwan provinces under the future climate conditions. Therefore, we recommend protecting the habitats of H. tetratepala in Yunnan and strengthening the in-depth species investigation and monitoring in areas (Hainan, Guangzhou, and Taiwan) where no related reports of H. tetratepala have been reported. The results improve our understanding of this species’ response under the changing climate and benefit strategies for its conservation.
Characterization of the complete chloroplast genome of Elaeagnus pungens (elaeagnaceae) and phylogeny within elaeagnaceae

Abstract Elaeagnus pungens is an evergreen shrub with high medicinal values. In this study, the complete chloroplast (cp) genome of E. pungens was characterized. The chloroplast genome of E. pungens is 152,218 bp in length, consisting of two 25,876 bp inverted repeats, 18,231 bp small single copy region, and 82,235 bp large single copy region. The chloroplast genome contains 113 unique genes, including 79 protein-coding genes, 30 tRNA genes, and 4 rRNA genes. Phylogenomic analysis revealed that E. pungens and species from Elaeagnus formed a monophyletic clade sister to the clade consisting of species from Hippophae.