Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlations between the histopathological alterations in minor salivary glands and the clinically suspected Sjögren’s syndrome

In sicca syndrome patients the xerostomia, xerophthalmia and the serological findings may strongly suggest the autoimmune Sjögren’s syndrome, but the histological findings in the labial salivary gland biopsies do not always justify the suspected diagnosis. The aim of this study was to compare the histomorphological changes and the clinical findings in patients with pathologically established Sjögren’s syndrome and in cases with negative histology. A total of 133 labial biopsies have been retrospectively evaluated from 2015 to May 2022, and the characteristic Sjögren’s lesions were found in 67 cases. According to the clinical data, 34 cases proved to be primary, and 33 were associated (“secondary”) forms. In 66 cases, the histology did not justify Sjögren’s syndrome; a significant acinar loss, fibrolipomatous infiltration, and mild sialadenitis had led to the clinical symptoms. In Sjögren’s histologies, the acinar loss was detected in just 31.8% of cases, which might indicate that the diminished saliva production represents immune-mediated hypofunction rather than direct damage of the acini. This is the first systemic study in Hungary investigating the correlation between pathological alterations and clinical findings.
Modification of the therapist’s facial expressions using virtual reality technology during the treatment of social anxiety disorder: a case series

Exposure therapy is a mainstream of treatment for social anxiety disorder (SAD). However, effort and time are required to recreate interpersonal situations that produce moderate anxiety. On the other hand, virtual reality exposure therapy can easily control anxiety-inducing conditions and allow for graduated exposure. However, artificial intelligence and animations that speak as naturally as actual humans are not yet practical, adding to the limitations of these treatments. The authors propose the use of a virtual reality technology that can transform facial expressions into smiling or sad faces in real time and display them on a monitor, potentially solving the above-mentioned problems associated with virtual reality animations. This feasibility study was conducted to determine whether this system can be safely applied to the treatment of SAD patients. A total of four SAD patients received 16 exposure therapy sessions led by an experienced therapist over a monitor; throughout the sessions, the facial expressions of the therapist were modified using software to display expressions ranging from smiling to sad on the monitor that was being viewed by the patient. Client satisfaction, treatment alliance, and symptom assessments were then conducted. Although one patient dropped out of the study, treatment satisfaction and treatment alliance were scored high in all the cases. In two of the four cases, the improvement in symptoms was sustained over time. Exposure therapy in which the interviewer’s facial expressions are modified to induce appropriate levels of anxiety in the patient can be safely used for the treatment of SAD patients and may be effective for some patients.
NEXUS BETWEEN WORKING CAPITAL MANAGEMENT (WCM) AND FIRM PERFORMANCE: EMPIRICAL EVIDENCE FROM MANUFACTURING SECTOR OF PAKISTAN USING GMM APPROACH

Centered on the empirical evidence of Pakistani firms, this study aims to examine the relationship between working capital management and the performance of a company. A sample of 40 manufacturing firms listed on the PSX for the five-year period (2015-2019) were selected for analysis. Since working capital plays a major role in improving business performance, managers must find the effect of WCM on the performance of the company and manage WCM efficiently to improve profitability performance (ROA). Panel data regression is used to investigate the relation of WCM to the performance of a firm. As a result, the empirical findings of the regression analysis show that there is a significant negative relationship between ROA and CCC, and APP of manufacturing firms. Which is consistent with the earlier studies that longer the CCC and APP decline the profitability of the firm. On the other hand, ACP and InvTD have an insignificant effect on ROA for manufacturing firms. Conclusively, WCM has a substantial effect on the performance of manufacturing firms. Also, Due to endogeneity bias, the result of our analyses indicates significant differences in findings reported under the ordinary least square (OLS) approach, fixed effects, and the generalized method of moments (GMM) estimations.
Debt Financing and Performance of Firms in Pakistan

The examination of variables that can affect the profitability of the firms is the main purpose of this study. The aim of this study is to find out the effects of dependent on independent variables thoroughly. Profitability is the dependent variable used in this study and accounts payables, short term debt and long-term debt and the control variables are size, and age of the firms are the independent variables that has been used. For this purpose, the quantitative approach has been used. All the data has been used in this study is collected from the official website of Pakistan Stock Exchange PSX. The result of this study shows that the no other variable has any significant impact on the profitability of firms accept long term debt. This means that the companies should go for equity financing and not for the debt financing. All variables of debt financing that are considered for this study are, short term debt, long term debt and accounts payable suggests that companies should go for equity financing. The control variables of the study do not have any effect on the profitability of the firm but for the SMEs the size of the firms impacts the profitability. The managers of the firms should go for the internal financing for the higher profitability.
Evidence for a normal mode Kelvin wave in the atmosphere

Confirmation en utilisant une longue serie d'observations dans 3 stations tropicales, du mode libre, caracteristique (normal mode) resonnant, de periode 33 h, a propagation de phase de l'ouest vers l'est identifie a une onde de Kelvin particuliere, et decouvert par Matsuno (1980)
MUC4 Expression in Oral Dysplastic Epithelium and Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Objective: MUCIN4 (MUC4) glycosylation is linked to the oncogenesis and progression of a neoplastic process. It can suggest information pertaining to tumor progression, management and its natural properties. Thus, MUC4 can play a pivotal role in prognostic diagnosis. This study aimed to analyze the MUC4 expression in oral cell squamous carcinoma and oral dysplastic epithelium. Materials and Methods: The research included 45 samples of oral epithelial dysplasia (OED) and 45 cases of oral squamous cell carcinoma (OSCC). In order to carry out the investigation, tissue blocks of previously diagnosed cases of OED and OSCC were retrieved from the relevant archives. Forty-five OED cases were categorized into three group’s mild, moderate and severe dysplasia, with 15 cases in each respective category. Forty-five OSCC cases were categorized into three groups: well differentiated, moderately differentiated, and poorly differentiated OSCC with 15 cases in each respective category. Ten tissue biopsies of normal oral mucosa were obtained from subjects in the control group. The chi-square test and one-way ANOVA were used for statistical analysis. Result: There was an absence of MUC4 expression in normal mucosa, whereas the OED and OSCC groups had a significant amount of observable variance. Within the OED category of cases, a consistent progression from mild to severe dysplasia was seen in terms of the staining pattern. Cases with severe dysplasia displayed a staining pattern that covered the complete thickness of the tissue in the epithelium. Expression of MUC4 was shown to be lower in moderate differentiated squamous cell carcinoma (MDSCC), and poorly differentiated squamous cell carcinoma (PDSCC) as compared to well differentiated squamous cell carcinoma (WDSCC). It showed decreasing pattern across all grades of OSCC. In WDSCC, an intense highest staining response was noticed, particularly among the cells that are highly differentiated and take the form of a honeycomb pattern. Conclusion: Analysis of the expression profile of MUC4 and the aberrant expression of this gene in OSCC suggests that it may serve as a useful diagnostic marker. Therefore, it is possible to draw the conclusion that MUC4 plays a very significant part in the pathogenesis of OSCC and also acts as a marker that may be taken into consideration for the accurate diagnosis of OED and OSCC.
Modern soil aggregates–colluvium generated by overland flow – stratigraphy and physical experiments

In tropical and subtropical zones, sandy colluviums composed of soil aggregates are highly significant for the understanding of depositional processes in the natural realm. The formation processes of soil aggregates–colluviums (pedosediments in other climate zones) are poorly defined. Deeper knowledge on the origin of soil aggregates–colluviums from low‐density or high‐density overland flows is essential for improved understanding of colluviums found in modern, Quaternary and ancient stratigraphic records. The understanding of depositional processes of soil aggregates–colluviums has been integrated into this study by combining macrostratigraphy and microstratigraphy and laboratory experimental techniques. The actualism principle was applied using a sedimentological description of a modern soil aggregates–colluvium deposit generated by overland flows. In addition, physical experiments were performed to simulate the natural sedimentation processes of overland flows composed of various sediment concentrations. The results indicate the maximum grain size (granules and pebbles) of the soil aggregates–colluvium beds originating from high competence overland flows involving large volumes of local rainfall (storms). Overland flows are responsible for laminated beds of soil aggregates–colluviums; however, the laminations are heterogeneous sequences compared to those of low‐density flows, which have homogeneous sequences. The microstratigraphy of the natural, modern soil aggregates–colluviums shows varied structures in overland flow laminations, implying several types of flow density. The internal organization of the laminae suggests that the accretion of the colluvium deposit occurred through high‐density flows and high to low‐transitional density flows. Low‐density flows were less frequent and may constitute either single or more diluted tail flows. Finally, overland flow can generate facies with similar end members to mass movements, being distinguished only by bed thickness. Linking field observations with experimental results, as in the present study, leads to deeper understanding of overland flow sedimentation processes, especially in tropical and subtropical zones.
High‐order split‐step theta methods for non‐autonomous stochastic differential equations with non‐globally Lipschitz continuous coefficients

In this paper, we first propose the so‐called improved split‐step theta methods for non‐autonomous stochastic differential equations driven by non‐commutative noise. Then, we prove that the improved split‐step theta method is convergent with strong order of one for stochastic differential equations with the drift coefficient satisfying a superlinearly growing condition and a one‐sided Lipschitz continuous condition. Finally, the obtained results are verified by numerical experiments. Copyright © 2016 John Wiley & Sons, Ltd.
Thermo-Electrical Mathematical Model for Prediction of Ni-Cr Hot-Wire Temperature in Free Air and Inside Small Circular Cavities

ABSTRACT A one-dimensional thermo-electrical mathematical model describing the heating and cooling of thin Ni-Cr20% wires is presented. The model is applied for wires in a free air environment and to wires placed in small circular cavities formed by expanded polystyrene material. The basis of the model is a semicoupled solution of the heat conduction equation and the electrical diffusion equation in a one-dimensional (1-D) control volume finite-difference framework. A study on the available natural convection correlations for thin metal wires for Rayleigh numbers in the range of 10−3–101 is carried out in order to select an appropriate heat transfer coefficient for the time-dependent heating and cooling of a wire. The model is tested against experimental data and is found to be in a good agreement with previous investigations. Based on the findings, expressions for the heat transfer coefficient of a hot wire inside a small circular cavity are suggested.
Skill Assessment of HF Radar–Derived Products for Lagrangian Simulations in the Bay of Biscay

AbstractSince January 2009, two long-range high-frequency (HF) radar systems have been collecting hourly high-spatial-resolution surface current data in the southeastern corner of the Bay of Biscay. The temporal resolution of the HF radar surface currents permits simulating drifter trajectories with the same time step as that of real drifters deployed in the region in 2009. The main goal of this work is to compare real drifter trajectories with trajectories computed from HF radar currents obtained using different methods, including forecast currents. Open-boundary modal analysis (OMA) is applied to the radar radial velocities and then a linear autoregressive model on the empirical orthogonal function (EOF) decomposition of an historical data series is used to forecast OMA currents. Additionally, the accuracy of the forecast method in terms of the spatial and temporal distribution of the Lagrangian distances between observations and forecasts is investigated for a 4-yr period (2009–12). The skills of the d.
Transient heat diffusion with a non-singular fading memory: From the Cattaneo constitutive equation with Jeffrey’s Kernel to the Caputo-Fabrizio time-fractional derivative

Starting from the Cattaneo constitutive relation with a Jeffrey’s kernel the derivation of a transient heat diffusion equation with relaxation term expressed through the Caputo-Fabrizio time fractional derivative has been developed. This approach allows seeing the physical background of the newly defined Caputo-Fabrizio time fractional derivative and demonstrates how other constitutive equations could be modified with non-singular fading memories.
Genetic correlation, causal relationship, and shared loci between vitamin D and COVID‐19: A genome‐wide cross‐trait analysis

Observational studies have shown that vitamin D supplementation reduces the risk of COVID‐19 infection, yet little is known about the shared genomic architectures between them. Leveraging large‐scale genome‐wide association study (GWAS) summary statistics, we investigated the genetic correlation and causal relationship between genetically determined vitamin D and COVID‐19 using linkage disequilibrium score regression and Mendelian randomization (MR) analyses, and conducted a cross‐trait GWAS meta‐analysis to identify the overlapping susceptibility loci of them. We observed a significant genetic correlation between genetically predicted vitamin D and COVID‐19 (rg = −0.143, p = 0.011), and the risk of COVID‐19 infection would decrease by 6% for every 0.76 nmol L−1 increase of serum 25 hydroxyvitamin D (25OHD) concentrations in generalized MR (OR = 0.94, 95% CI: 0.89–0.99, p = 0.019). We identified rs4971066 (EFNA1) as a risk locus for the joint phenotype of vitamin D and COVID‐19. In conclusion, genetically determined vitamin D is associated with COVID‐19. Increased levels of serum 25OHD concentration may benefit the prevention and treatment of COVID‐19.
Global solutions and finite time blow-up for fourth order nonlinear damped wave equation

In this paper, we study a class of fourth order wave equations with nonlinear damping term and nonlinear source term. The global existence, decay estimate and blow up of solutions at both sub-critical and critical initial energy levels obtained. Moreover, we present some sufficient conditions on initial data such that the weak solution exists globally or blows up at sup-critical initial energy level. This paper is funded by the International Exchange Program of Harbin Engineering University for Innovation-oriented Talents Cultivation.
A monocular visual inertial SLAM algorithm with point-line feature fusion

: A monocular visual inertial SLAM algorithm with point-line feature fusion is proposed to solve the problem that the system fails to achieve high accuracy because of the few effective feature points extracted in weak scenes and the tracking failure of the algorithm in rapid movements. With reference to the open-source VINS-Mono system, a modified LSD algorithm is applied to the front end odometer to detect line features so as to extract more feature of the environment while balancing the accuracy and efficiency. We evaluate the performance of our algorithm in public dataset EUROC MAV as well as compare it with VINS-Mono, the experimental results show that the localization accuracy of our algorithm improves about 21.5%.
Technostress and Online Teaching During COVID-19 Pandemic: The Case of Lebanon

During the COVID-19 pandemic, several countries have eliminated face-to-face classes in all schools, requiring all teachers to deliver classes remotely. In this regard, the wide spread of information and communication technology (ICT) products and services in the educational sector became a burden for several teachers. This article aims to study the impact of online teaching, and how technological stress might vary between male and female teachers and to what extent it alters their family lives and their way of living. The case of Lebanon has been examined and analyzed using 379 participants in various schools randomly distributed throughout the country, who participated in a survey on how COVID-19 affected their technostress levels. The findings showed that married women were more prone to technological stress and that their family life and lifestyle were strongly affected. In particular, young women with few years of experience were more likely to experience technostress problems. We also found no differences related to educational levels. In addition, the inclusion of different degrees of computer self-efficacy has shown an impact on the development of technostress among individuals.
Analysis of Cutaneous Lupus Hospitalizations: A United States National Population-Based Study

Background There are limited studies analyzing cutaneous lupus erythematosus (CLE) hospitalizations. In this study, we aimed to analyze baseline demographics of systemic lupus erythematosus (SLE) and CLE patients, identify the most common reasons for hospitalizations, and find out the hospitalization outcomes. Materials and methods We performed the analysis using the National (Nationwide) Inpatient Sample (NIS) database between 2016 and 2019. For the CLE cohort, data for adults aged 18 years and older with the primary or secondary diagnosis of CLE using International Classification of Disease - 10th revision (ICD-10) codes were extracted. For comparison, the SLE cohort was identified by patients aged 18 years and older with primary or secondary diagnoses of SLE using ICD-10 codes. Chi-squared test was used to compare baseline demographic characteristics. Multivariable logistic and linear regression was used to calculate outcomes of interest. Results In comparison to the SLE cohort, the CLE cohort was not only older in age and lower percentage female, but also had shorter length of stay, less total hospital charge, and the majority had Medicare as primary insurance. The SLE cohort included predominantly African American patients while the CLE cohort was majority Caucasian patients. The cardiovascular risks were more prevalent in the CLE cohort and most commonly admitted for sepsis, cardiovascular disease, and mental health disorders. Conclusion Our study highlights the importance of outpatient follow-up in CLE patients to closely monitor cardiovascular risk factors, early identification of infections, and routine mental health screenings to reduce hospitalizations and resource utilization.
Self-Efficacy Mahasiswa dalam Pembuktian Matematis

Pembuktian matematis merupakan kemampuan yang sangat penting bagi mahasiswa pendidikan matematika. Agar sukses dalam pembuktian matematis, diperlukan suatu keyakinan terhadap kemampuan dirinya sendiri. Keyakinan akan kemampuan diri untuk dapat mencapai suatu hal dinamakan self-efficacy. Karena pentingnya self-efficacy, sebuah penelitian telah dilaksanakan untuk mengetahui bagaimana self-efficacy mahasiswa dalam pembuktian matematis. Kuesioner yang berisi 24 pernyataan diberikan kepada 44 mahasiswa salah satu universitas di Aceh Utara yang telah belajar topik metode pembuktian matematis. Hasil penelitian menunjukkan bahwa 40,1% mahasiswa memiliki self-efficacy tinggi, 59,9% mahasiswa dengan self-efficacy sedang dan tidak ada yang memiliki self-efficacy rendah. Dari hasil tersebut dapat disimpulkan bahwa kebanyakan mahasiswa memiliki self-efficacy sedang. Namun, tidak sedikit juga tingkat self-efficacy mahasiswa sudah berada pada level tinggi yang artinya mereka memiliki kepercayaan yang baik akan kemampuan dirinya untuk sukses dalam pembuktian matematis. Hal tersebut menjadi modal penting dalam usaha untuk terus meningkatkan kemampuan pembuktian matematis.
Fabrication and characterization of PCBM:P3HT:silicon phthalocyanine bulk heterojunction solar cells with inverted structures

[6,6]-phenyl C61-butyric acid methyl ester and poly(3-hexylthiophene) bulk heterojunction solar cells doped with silicon phthalocyanine (SiPc) were fabricated and characterized. The photovoltaic properties of the solar cells with an inverted structure were improved by the SiPc addition, which were investigated on the bases of current density–voltage characteristics, incident photon to current conversion efficiency, and internal quantum efficiency. The solar cell with the inverted structure also showed good stability in air compared with the normal stacking devices. The microstructure of the solar cells was investigated by X-ray diffraction and transmission electron microscopy, and the carrier separation and transfer of the solar cells were discussed.