Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co‐expressing HCV core protein and CYP2E1

Hepatitis C virus (HCV) and HCV core protein are hypothesized to induce hepatic oxidative stress and exacerbate injury caused by other toxins such as ethanol that induce the cytochrome P450 enzyme, CYP2E1. In the current study, the effects of HCV core protein [sequence genotype 1b, (nt 342–915)] on parameters indicative of oxidative stress were evaluated in HepG2 cells stably over expressing CYP2E1 (E47), or vector controls (C34). Stable (>10 passages) expression of HCV core protein and CYP2E1 was confirmed in clonal cell lines at the level of mRNA and immunoreactive protein. Prooxidant production, as determined by cellular oxidation of dichlorodihydrofluorescin and dihydroethidium (HE), was increased by expression of HCV core protein in the presence or absence of CYP2E1. Depletion of glutathione (GSH) with buthionine sulfoximine (BSO) enhanced prooxidant production in both C34 and E47 cells. In addition, prooxidant production was greater in BSO‐treated cells expressing HCV core protein, and this effect was further enhanced in cells expressing both HCV core and CYP2E1. The CYP2E1 inhibitor, 4‐methylpyrazole, could suppress increased prooxidant production in E47 cells. Finally, cells co‐expressing both CYP2E1 and HCV core protein showed significantly decreased viability following GSH depletion. These studies show simultaneous expression of HCV core protein and CYP2E1 increases parameters indicative of oxidative stress as well as sensitization to cell injury induced by GSH depletion. These results support the hypothesis that enhanced injury in hepatocytes over expressing both HCV core protein and CYP2E1 is mediated by increases in oxidative stress. J. Med. Virol. 72:230–240, 2004. © 2004 Wiley‐Liss, Inc.
Design a web portal for visualizing and exploring service quality of global OGC Web Map Services

Selecting satisfactory web service instances from massive providers is significant and also challenging, since multiple factors, snch as end users' qnality requirements and preferences, need to be considered in the selecting process. To partially address this issue, this paper introduces a sophisticated neb portal, which is designed for visualizing and exploring the service qnality of global OGC Web Map Services (WMS). The web portal allows end users to query and filter services through Interaction. To intuitively express and convey the information of retrieved services to nsers. multiple visualization methods are Integrated, Including lists, tables, charts and maps. Visualization controls snch as Map World, Dojo. and Highcharts are utilized to enhance nser interactivity and provide enriched expression of service quality. The monitoring results of 584 OGC services distributed globally are used as the data source, which Is coDected from 17 global monitoring sites. The monitored quality metric from both service level and layer level are recorded and displayed, including FGDC score, response time, availability, etc. The monitored data can be used to investigate the spaQotemporal characteristic of the service quality. User experiments prove that, by using the web portal, they can judge and distinguish services according to the quality intuitively. Challenges and future works are discussed to enlighten potential future research on the qnality of geographic information services (QoGIS), snch as usual evaluation.
Jadeite in shocked meteorites and its textural variations

Jadeite occurs as the shocked product of albite feldspar in shocked meteorites, and is one of the most common high–pressure polymorphs in shock–melt veins of meteorites. The characteristic textures of jadeite in shocked ordinary chondrites show that some of jadeite crystals were formed from originally albite feldspar by a solid– state transformation and some were crystallized from a shock–induced albite melt. Based on these textures of jadeite together with the other high–pressure mineral assemblages and their crystallization kinetics, we can estimate the impact conditions such as impact velocity and parent–body size.
Electronic text corpus of Sumerian literature (ETCSL)

A selection of nearly 400 literary compositions recorded on sources which come from ancient Mesopotamia and date to the late third and early second millennia BCE. The corpus contains Sumerian texts in transliteration, English prose translations and bibliographical information for each composition. The transliterations and the translations can be searched, browsed and read online using the tools of the website.
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION XXIX. SERUM ALBUMIN AS A DILUENT FOR Rh TYPING REAGENTS.

During the last two years methods for the separation and concentration of the anti-Rh isoagglutinins have been developed as a part of the study of the fractionation of human plasma (1). The solubility characteristics on which the separation has been based resemble those of the anti-A and anti-B isoagglutinins, and have been summarized in a previous communication (2). The final products have been prepared as protein powders, stable and readily soluble, which may be packaged in convenient quantities and reconstituted to yield potent reagents useful for Rh typing or for A or B grouping, respectively. In contrast to the anti-A and anti-B isoagglutinins, which may be obtained readily from grouped plasma pools from normal donors (3), the available supply of anti-Rh material is limited. The incidence of anti-Rh agglutinins in the general population is very low, and bleedings suitable as a source of original plasma for processing "'must be obtained from sensitized Rh negative donors, specially selected (2). Moreover, the phenomenon, termed "blocking," 8 whereby the antibodies in certain anti-Rh serums fail to agglutinate homologous Rh positive cells in sodium chloride solutions, but appear to combine with them and to inhibit the action of Rh agglutinins (4, 7, 8), has made these serums and the anti-Rh globulin
Developmental Commonalities between Object and Face Recognition in Adolescence

In the visual perception literature, the recognition of faces has often been contrasted with that of non-face objects, in terms of differences with regard to the role of parts, part relations and holistic processing. However, recent evidence from developmental studies has begun to blur this sharp distinction. We review evidence for a protracted development of object recognition that is reminiscent of the well-documented slow maturation observed for faces. The prolonged development manifests itself in a retarded processing of metric part relations as opposed to that of individual parts and offers surprising parallels to developmental accounts of face recognition, even though the interpretation of the data is less clear with regard to holistic processing. We conclude that such results might indicate functional commonalities between the mechanisms underlying the recognition of faces and non-face objects, which are modulated by different task requirements in the two stimulus domains.
Mining flexible association rules from XML

The role of the eXtensible Markup Language (XML) is becoming very important in the research fields focusing on the representation, the exchange, and the integration of information coming from different data sources and containing information related to various contexts such as, for example, medical and biological data. Extracting knowledge from XML datasets is an important issue that may be difficult because of the semistructured intrinsic nature of XML; indeed documents can have an implicit and irregular structure, not defined in advance. In this paper, we propose a novel approach for discovering frequent, but approximate, information in XML documents, based on Flexible Tree Rules taking into account both structure and content of the analyzed data. Our proposal is flexible enough to be adapted to both documents with a regular structure and documents with a highly heterogeneous structure, and can be used to evaluate the similarity of XML documents. Moreover, we describe an algorithm to evaluate the similarity degree of a Flexible Tree Rule with respect to an XML document.
Trickle: A Userland Bandwidth Shaper for UNIX-like Systems

As with any finite resource, it is often necessary to apply policies to the shared usage of network resources. Existing solutions typically implement this by employing traffic management in edge routers. However, users of smaller networks regularly find themselves in need of nothing more than ad-hoc rate limiting. Such networks are typically unmanaged, with no network administrator(s) to manage complicated traffic management schemes. Trickle bridges this gap by providing a simple and portable solution to rate limit the TCP connections of a given process or group of processes. Trickle takes advantage of the Unix dynamic loader's preloading functionality to interposition itself in front of the BSD socket API provided by the system's libc. Running entirely in user space, shapes network traffic by delaying and truncating socket I/Os without requiring administrator privileges. Instances of Trickle can cooperate, even across networks allowing for the specification of global rate limiting policies. Due to the prevalence of BSD sockets and dynamic loaders, Trickle enjoys the benefit of portability accross a multitude of Unix-like platforms.
Adaptive Traffic Signal Coordination with a Game Theoretic Approach

5 CHAPTER 1: INTRODUCTION . 6 1.1 BACKGROUND . 6 1.2 RESEARCH OBJECTIVES . 7 1.3 THESIS ORGANIZATION . 7 CHAPTER 2: LITERATURE REVIEW . 9 2.1 TRAFFIC SIGNAL OFFSET AND COORDINATION OPTIMIZATION . 9 2.2 THE APPLICATIONS OF GAME THEORY IN TRAFFIC SIGNAL CONTROL . 12 2.3 COORDINATION EFFECTS OF CONNECTED AND AUTOMATED VEHICLES . 14 CHAPTER 3: METHODLOGY . 18 3.1 MODELING DESCRIPTION . 18 3.2 DELAY CALCULATION. 20 3.3 GAME THEORETIC SOLUTION . 22 3.4 MODELING OF CAV . 23 CHAPTER 4: SIMULATION RESULTS AND ANALYSIS . 25 4.1 RESULTS AND ANALYSIS OF HVS . 26 4.1.1 Simulation of Model 1 . 26 4.1.2 Simulation of Model 2 . 29 4.1.3 Simulation of Model 3 . 31 4.1. 4 Simulation of Model 4 . 33 4.2 RESULTS AND ANALYSIS OF CAVS . 36 CHAPTER 5: CONCLUSION AND FUTURE WORK . 37 BIBLIOGRAPHY . 38
Assessment of Secondary School Students’ Game Performance Related to Tactical Contexts

Abstract Certain limitations remain unaddressed when utilizing the Teaching Games for Understanding approach, suggesting the need for more research on authentic assessment of skill development and tactical awareness in order to guide the design of developmentally appropriate curriculum materials. This study investigated physical education students’ (n=19; age: 13.71 ± 0.4) game performance during an invasion game, specifically the relationship between their skill execution and decision-making ability. The purpose of the study was twofold: (a) to devise and implement a ‘game context’ approach to assess the game performance components and in doing so, (b) to provide information that could be used to design suitable learning progressions within tactical teaching approaches. Students’ game performance was videotaped, and measures of skill execution and decision-making were developed from observational analyses. Decision-making was measured at two levels: a) decision making restricted to the selection of technical-tactical skills (i.e., passing, moving with the ball, getting free, marking, tackling, double teaming and interception; and b) decisionmaking in the adaptation to the tactical contexts of the game. Participants played a 5 vs. 5 modified eight-minute team handball game. Participants scored significantly higher in penetrating-the-defense context adaptation than in keepingthe- ball context adaptation. Participants showed a higher efficiency in decision-making than in execution in most of the technical-tactical skills; including on-the-ball over off-the-ball decision-making, and in attack compared to defensive execution. The findings also revealed significant relationships between decision-making and skill execution in shooting, tackling and passing
Innovative Approaches Helpful to Enhance Knowledge on Weather-Related Stroke Events Over a Wide Geographical Area and a Large Population

Background and Purpose— Results on the effect of weather on stroke occurrences are still confusing and controversial. The aim of this study was to retrospectively investigate in Tuscany (central Italy) the weather-related stroke events through the use of an innovative source of weather data (Reanalysis) together with an original statistical approach to quantify the prompt/delayed health effects of both cold and heat exposures. Methods— Daily stroke hospitalizations and meteorologic data from the Reanalysis 2 Achieve were obtained for the period 1997 to 2007. Generalized linear and additive models and an innovative modeling approach, the constrained segmented distributed lag model, were applied. Results— Both daily averages and day-to-day changes of air temperature and geopotential height (a measure that approximates the mean surface pressure) were selected as independent predictors of all stroke occurrences. In particular, a 5°C temperature decrease was associated with 16.5% increase of primary intracerebral hemorrhage of people ≥65 years of age. A general short-term cold effect on hospitalizations limited to 1 week after exposure was observed and, for the first time, a clear harvesting effect (deficit of hospitalization) for cold-related primary intracerebral hemorrhage was described. Day-to-day changes of meteorologic parameters disclosed characteristic U- and J-shaped relationships with stroke occurrences. Conclusions— Thanks to the intrinsic characteristic of Reanalysis, these results might simply be implemented in an operative forecast system regarding weather-related stroke events with the aim to develop preventive health plans.
Debugging Program Exceptions

University of South Australia, Technische Universität Graz Advanced Computing Research Centre Institute for Software Technology 5095 Mawson Lakes SA, Adelaide, Australia 8010 Graz, Inffeldgasse 16b/2, Austria mayer,mst @cs.unisa. edu.au wotawa@ist.tugraz. at Even with modern software development methodologies, the actual debugging of source code, i.e., location and identification of errors in the program when errant behavior is encountered during testing, remains a crucial part of software development. To apply model-based diagnosis techniques, which have long been state of the art in hardware diagnosis, for automatic debugging, a model of a given program must be automatically created from the source code. This work describes a model that reflects the execution semantics of the Java language, including exceptions and unstructured control flow, thereby providing unprecedented scope in the application of model-based diagnosis to programs. Notably, this approach omits the strict view of a component representing one statement of earlier work and provides a more flexible mapping from code to model.
Globus: a Metacomputing Infrastructure Toolkit

The Globus system is intended to achieve a vertically integrated treatment of application, middleware, and net work. A low-level toolkit provides basic mechanisms such as communication, authentication, network information, and data access. These mechanisms are used to con struct various higher level metacomputing services, such as parallel programming tools and schedulers. The long- term goal is to build an adaptive wide area resource environment (AWARE), an integrated set of higher level services that enable applications to adapt to heteroge neous and dynamically changing metacomputing environ ments. Preliminary versions of Globus components were deployed successfully as part of the I-WAY networking experiment.
Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes

Natural selection often produces convergent changes in unrelated lineages, but the degree to which such adaptations occur via predictable genetic paths is unknown. If only a limited subset of possible mutations is fixed in independent lineages, then it is clear that constraint in the production or function of molecular variants is an important determinant of adaptation. We demonstrate remarkably constrained convergence during the evolution of resistance to the lethal poison, tetrodotoxin, in six snake species representing three distinct lineages from around the globe. Resistance-conferring amino acid substitutions in a voltage-gated sodium channel, Nav1.4, are clustered in only two regions of the protein, and a majority of the replacements are confined to the same three positions. The observed changes represent only a small fraction of the experimentally validated mutations known to increase Nav1.4 resistance to tetrodotoxin. These results suggest that constraints resulting from functional tradeoffs between ion channel function and toxin resistance led to predictable patterns of evolutionary convergence at the molecular level. Our data are consistent with theoretical predictions and recent microcosm work that suggest a predictable path is followed during an adaptive walk along a mutational landscape, and that natural selection may be frequently constrained to produce similar genetic outcomes even when operating on independent lineages.
Adaptive Choice of the Number of Bootstrap Samples in Large Scale Multiple Testing

It is a common practice to use resampling methods such as the bootstrap for calculating the p-value for each test when performing large scale multiple testing. The precision of the bootstrap p-values and that of the false discovery rate (FDR) relies on the number of bootstraps used for testing each hypothesis. Clearly, the larger the number of bootstraps the better the precision. However, the required number of bootstraps can be computationally burdensome, and it multiplies the number of tests to be performed. Further adding to the computational challenge is that in some applications the calculation of the test statistic itself may require considerable computation time. As technology improves one can expect the dimension of the problem to increase as well. For instance, during the early days of microarray technology, the number of probes on a cDNA chip was less than 10,000. Now the Affymetrix chips come with over 50,000 probes per chip. Motivated by this important need, we developed a simple adaptive bootstrap methodology for large scale multiple testing, which reduces the total number of bootstrap calculations while ensuring the control of the FDR. The proposed algorithm results in a substantial reduction in the number of bootstrap samples. Based on a simulation study we found that, relative to the number of bootstraps required for the Benjamini-Hochberg (BH) procedure, the standard FDR methodology which was the proposed methodology achieved a very substantial reduction in the number of bootstraps. In some cases the new algorithm required as little as 1/6th the number of bootstraps as the conventional BH procedure. Thus, if the conventional BH procedure used 1,000 bootstraps, then the proposed method required only 160 bootstraps. This methodology has been implemented for time-course/dose-response data in our software, ORIOGEN, which is available from the authors upon request.
Improving the performance of object-oriented languages with dynamic predication of indirect jumps

Indirect jump instructions are used to implement increasingly-common programming constructs such as virtual function calls, switch-case statements, jump tables, and interface calls. The performance impact of indirect jumps is likely to increase because indirect jumps with multiple targets are difficult to predict even with specialized hardware. This paper proposes a new way of handling hard-to-predict indirect jumps: dynamically predicating them. The compiler (static or dynamic) identifies indirect jumps that are suitable for predication along with their control-flow merge (CFM) points. The hardware predicates theinstructions between different targets of the jump and its CFM point if the jump turns out to be hard-to-predict at run time. If the jump would actually have been mispredicted, its dynamic predication eliminates a pipeline flush, thereby improving performance. Our evaluations show that Dynamic Indirect jump Predication (DIP) improves the performance of a set of object-oriented applications including the Java DaCapo benchmark suite by 37.8% compared to a commonly-used branch target buffer based predictor, while also reducing energy consumption by 24.8%. We compare DIP to three previously proposed indirect jump predictors and find that it provides the best performance and energy-efficiency.
Estradiol Selectively Enhances Auditory Function in Avian Forebrain Neurons

Sex steroids modulate vertebrate sensory processing, but the impact of circulating hormone levels on forebrain function remains unclear. We tested the hypothesis that circulating sex steroids modulate single-unit responses in the avian telencephalic auditory nucleus, field L. We mimicked breeding or nonbreeding conditions by manipulating plasma 17β-estradiol levels in wild-caught female Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii). Extracellular responses of single neurons to tones and conspecific songs presented over a range of intensities revealed that estradiol selectively enhanced auditory function in cells that exhibited monotonic rate level functions to pure tones. In these cells, estradiol treatment increased spontaneous and maximum evoked firing rates, increased pure tone response strengths and sensitivity, and expanded the range of intensities over which conspecific song stimuli elicited significant responses. Estradiol did not significantly alter the sensitivity or dynamic ranges of cells that exhibited non-monotonic rate level functions. Notably, there was a robust correlation between plasma estradiol concentrations in individual birds and physiological response properties in monotonic, but not non-monotonic neurons. These findings demonstrate that functionally distinct classes of anatomically overlapping forebrain neurons are differentially regulated by sex steroid hormones in a dose-dependent manner.
Effect of Soil Nailing On Stability of Slopes

In the present experimental work, the behaviour of the unreinforced and soil nailed slopes under different static surcharge load is carried out experimentally. The slopes are constructed of sand size soil at presumed soil slope angle of 60° with the horizontal plane. Different static load is applied on the bearing plate mounted on the crest of soil slope to observe the load vs. settlement behaviour. These soil slopes are then reinforced by installing aluminium hollow tubes as soil nails at three different inclinations of 0°, 15° and 30° with the horizontal plane keeping the horizontal and vertical spacing = 0.1m. The effect of soil nail pattern with in the soil slope is also analysed in the present study. Nails are installed in square, diamond and staggered arrangements. Stress and strain produced in the nails installed at different positions has been also found out in the present study with the help of strain gauges during the subsequent stages of loading. It is observed that nails inserted at 0 are more efficient in providing the stability to the slopes as compared to nails inserted at 15 and 30. Also nails installed in staggered pattern were found to be most efficient.