Miracle-dz/UniFAR-FTUs huggingface dataset:
Real‐world experience of secukinumab in moderate to severe psoriasis patients in Thailand: Characteristics, effectiveness, and safety

Secukinumab demonstrated high efficacy and favorable safety profile in patients with moderate‐to‐severe plaque psoriasis (PsO) in clinical trials. However, understanding of patient characteristics and clinical outcomes in real world in Thailand is still limited. To describe patient characteristics, effectiveness and safety of secukinumab in Thai PsO patients. This retrospective study analyzed data from medical records of adult PsO patients who initiated secukinumab at 7 dermatology centers from September 2017 to April 2021. Study outcomes included patient characteristics and changes in Psoriasis Area and Severity Index (PASI) score from baseline at weeks 4 and 16 after secukinumab initiation. Adverse events were recorded. Subgroup analyses by adherence rate and completeness of loading dose were performed. Of 163 patients, the mean (SD) age was 44.0 (14.0) years. Most patients (84.7%) were previously treated with topical therapy while 62.0% and 21.5% of patients had received systemic and biologic therapy, respectively. The mean baseline PASI score was 15.4 (9.3). Overall, the mean PASI score improved by 58.0% at week 4 and 78.4% at week 16. Statistically significant differences in PASI approvement were revealed among subgroups of patients with different loading dose and adherence rate. Adverse effects were reported in 8.0% of patients. The characteristics of patients in this study were slightly different from clinical trials in terms of demographic and clinical characteristics, as well as PsO treatment. Secukinumab was effective and safe in Thai patients with PsO, especially among those with complete loading dose and a higher adherence rate.
The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis

Increasing evidence shows that the host gut microbiota might be involved in the immunological cascade that culminates with the formation of tissue granulomas underlying the pathophysiology of hepato-intestinal schistosomiasis. In this study, we investigated the impact of Schistosoma mansoni infection on the gut microbial composition and functional potential of both wild type and microbiome-humanized mice. In spite of substantial differences in microbiome composition at baseline, selected pathways were consistently affected by parasite infection. The gut microbiomes of infected mice of both lines displayed, amongst other features, enhanced capacity for tryptophan and butyrate production, which might be linked to the activation of mechanisms aimed to prevent excessive injuries caused by migrating parasite eggs. Complementing data from previous studies, our findings suggest that the host gut microbiome might play a dual role in the pathophysiology of schistosomiasis, where intestinal bacteria may contribute to egg-associated pathology while, in turn, protect the host from uncontrolled tissue damage.
Factors associated with medication adherence among adults with asthma

Abstract Objective Asthma medication adherence is of crucial importance for successful disease management. The aim of this study was to identify and rank factors associated with medication adherence among adults with asthma in the general population. Methods We used data on physician-diagnosed asthma, medication adherence, and factors associated with asthma medication adherence from the Danish General Suburban Population Study using a cross-sectional study design. We ranked factors associated with asthma medication adherence based on the magnitude of odds ratios, and the population attributable fractions. Results Among 20,032 individuals from the general population, 1,128 (6%) suffered from asthma and 822 (73%) of these were adherent to asthma medications. Based on odds ratios, the three top-ranked factors associated with asthma medication adherence were asthma attacks within the past year (4.0; 95% CI: 2.9–5.5), allergy medication use (3.8; 2.6–5.6), and age above median (3.4; 2.4–4.7), followed by asthma severity markers like airway obstruction, and coughing with mucus. Based on population attributable fractions, the three top-ranked factors associated with adherence to asthma medications were asthma attacks within the past year (70%), age above median (57%), and use of allergy medication (49%). Conclusions The study showed that in the general population recent asthma attacks, higher age, and taking allergy medication were the three most important factors associated with asthma medication adherence. The importance of maintaining adherence to asthma medications even in the absence of severe disease or expressed asthma symptoms should be better communicated to the general population.
Relationship between long‐term use of Ritalin and semen parameters in patients referred to psychiatric centres

Some studies have shown that Ritalin can interfere with the growth and development of the reproductive system and can also have a serious and harmful effect on sperm parameters, so we decided to conduct studies in this field on the human sample. In a case–control study, 100 adult men aged 21–31 years with hyperactivity were divided into two groups of 50 past users and 50 current users and, 50 patients who had not used Ritalin before were included as the control group. Data were analysed using SPSS software, version 20. Analysis of variance, Pearson correlation coefficient, and regression analysis was used to assess the correlation between variables. The results also showed that there was a statistically significant difference between the current users and the control group in terms of sperm count, abnormality, and motility (p < .47). Comparison of the user group in the past and the control group showed that there was no statistically significant difference in terms of sperm count (p < .59), but there was a significant difference in terms of sperm motility and abnormality between the two groups (p < .001). The present study showed that long‐term use of Ritalin can have negative effects on sperm parameters in humans.
Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology

Most transgenic mouse models are generated through random integration of the transgene. The location of the transgene provides valuable information for assessing potential effects of the transgenesis on the host and for designing genotyping protocols that can amplify across the integration site, but it is challenging to identify. Here, we report the successful utility of optical genome mapping technology to identify the transgene insertion site in a CYP2A13/2B6/2F1-transgenic mouse model, which produces three human cytochrome P450 (P450) enzymes (CYP2A13, CYP2B6, and CYP2F1) that are encoded by neighboring genes on human chromosome 19. These enzymes metabolize many drugs, respiratory toxicants, and chemical carcinogens. Initial efforts to identify candidate insertion sites by whole genome sequencing was unsuccessful, apparently because the transgene is located in a region of the mouse genome that contains highly repetitive sequences. Subsequent utility of the optical genome mapping approach, which compares genome-wide marker distribution between the transgenic mouse genome and a reference mouse (GRCm38) or human (GRCh38) genome, localized the insertion site to mouse chromosome 14, between two marker positions at 4451324 base pair and 4485032 base pair. A transgene-mouse genome junction sequence was further identified through long-polymerase chain reaction amplification and DNA sequencing at GRCm38 Chr.14:4484726. The transgene insertion (∼2.4 megabase pair) contained 5–7 copies of the human transgenes, which replaced a 26.9–33.4 kilobase pair mouse genomic region, including exons 1–4 of Gm3182, a predicted and highly redundant gene. Finally, the sequencing results enabled the design of a new genotyping protocol that can distinguish between hemizygous and homozygous CYP2A13/2B6/2F1-transgenic mice. SIGNIFICANCE STATEMENT This study characterizes the genomic structure of, and provides a new genotyping method for, a transgenic mouse model that expresses three human P450 enzymes, CYP2A13, CYP2B6, and CYP2F1, that are important in xenobiotic metabolism and toxicity. The demonstrated success in applying the optical genome mapping technology for identification of transgene insertion sites should encourage others to do the same for other transgenic models generated through random integration, including most of the currently available human P450 transgenic mouse models.
Yield response of wheat (Triticum aestivum L.) to boron application at different growth stages

In field experiment in the University of Agriculture, Faisalabad, Pakistan conducted during winter 2006-07, yield response of wheat (Triticum aestivum L.) to boron application at different growth stages was investigated. Foliar application of Boron in Wheat at four different growth stages i.e at tillering, jointing, booting and anthesis was practiced. Number of grains per spike, 1000-grain weight and grain yield was significantly increased where boron was applied. Significantly higher yield was obtained where Boron was applied at booting stage. So, boron application at booting stage was found to be the best time for obtaining higher grain yield of wheat.
Photometry and spectroscopy of multiple populations along the AGB of NGC2808 and NGC6121 (M4)

We present a photometric and spectroscopic study of multiple populations along the asymptotic-giant branch (AGB) of the intermediate-metallicity globular clusters (GCs) NGC2808 and NGC6121 (M4). Chemical abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Fe, Co, Ni, Zn, Y, and Ce in AGB stars from high-resolution FLAMES+UVES@VLT spectra are reported for both clusters. Our spectroscopic results have been combined with multi-wavelength photometry from the HST UV survey of Galactic GCs and ground-based photometry, plus proper motions derived by combining stellar positions from ground-based images and Gaia DR1. Our analysis reveals that the AGBs of both clusters host multiple populations with different chemical composition. In M4 we have identified two main populations of stars with different Na/O content, lying on distinct AGBs in the mF438W vs. C_F275W,F336W,F438W and the V vs.C_U,B,I pseudo-CMDs. In the more massive and complex GC NGC2808 three groups of stars with different chemical abundances occupy different locations on the so-called "chromosome map" photometric diagram. The spectroscopic+photometric comparison of stellar populations along the AGB and the red giants of this GC suggests that the AGB hosts stellar populations with a range in helium abundances spanning from primordial up to high contents of Y~0.32. On the other hand, from our dataset, there is no evidence for stars with extreme helium abundance (Y~0.38) on the AGB, suggesting that the most He-rich stars of NGC2808 do not reach this phase.
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine expression is thought to be a major driver of chronic COVID-19 pathology. Although macrophages are not the primary target cells of SARS-CoV-2 infection in humans, viral RNA and antigens in activated monocytes and macrophages have been detected in post-mortem samples, and dysfunctional monocytes and macrophages have been hypothesized to contribute to a protracted hyper-inflammatory state in COVID-19 patients. In this study, we demonstrate that CD169, a myeloid cell specific I-type lectin, facilitated ACE2-independent SARS-CoV-2 fusion and entry in macrophages. CD169-mediated SARS-CoV-2 entry in macrophages resulted in expression of viral genomic and subgenomic RNAs with minimal viral protein expression and no infectious viral particle release, suggesting a post-entry restriction of the SARS-CoV-2 replication cycle. Intriguingly this post-entry replication block was alleviated by exogenous ACE2 expression in macrophages. Restricted expression of viral genomic and subgenomic RNA in CD169+ macrophages elicited a pro-inflammatory cytokine expression (TNFα, IL-6 and IL-1β) in a RIG-I, MDA-5 and MAVS-dependent manner, which was suppressed by remdesivir treatment. These findings suggest that de novo expression of SARS-CoV-2 RNA in macrophages contributes to the pro-inflammatory cytokine signature and that blocking CD169-mediated ACE2 independent infection and subsequent activation of macrophages by viral RNA might alleviate COVID-19-associated hyperinflammatory response.
Early distribution of18 F‐labeled AAV9 vectors in the cerebrospinal fluid after intracerebroventricular or intracisternal magna infusion in non‐human primates

The delivery of adeno‐associated virus (AAV) vectors via the cerebrospinal fluid (CSF) has emerged as a valuable method for widespread transduction in the central nervous system. Although infusion into the cerebral ventricles is a common protocol in preclinical studies of small animals, the cisterna magna has been recognized as an alternative target for clinical studies because it can be reached in a less invasive manner using an intrathecal catheter via the subarachnoid space from a lumbar puncture.
Filgotinib for moderately to severely active ulcerative colitis

ABSTRACT Introduction Filgotinib is an oral Janus kinase type 1 (JAK1) selective inhibitor with demonstrated efficacy and safety in ulcerative colitis (UC). The aim of this review is to summarize the available evidence on pharmacological characteristics, efficacy, and safety of filgotinib in UC. Areas covered Pubmed, Scopus, and Embase databases were searched for all relevant studies reporting the efficacy and safety of filgotinib in patients with moderate to severe UC. We particularly focused on the risk of zoster infection and venous thromboembolism compared to other JAK inhibitors. Expert opinion Filgotinib has remarkable efficacy, safety, and tolerability profiles in the treatment of moderate-to-severe active UC. It can be used in both biologic-naïve and biologic-experienced patients. The rapid mechanism of action and its oral administration route make it a reliable therapeutic option.
Spin-polarized currents driven by spin-dependent surface screening

We have examined the spin polarization of the electron current in a ferromagnetic metal induced by the spin-dependent surface screening at the dielectric-ferromagnetic metal (D-FM) interface. In an applied ac voltage, the dynamic band splitting driven by the changes in the screening charge at the D-FM interface develops spin accumulation. The resultant spin accumulation gradient produces a time-dependent spin current. We have derived the rate of the spin accumulation on the rate of the screening charge density accumulation within the Stoner band model. The spin-charge dynamics in the system is then modeled by a set of diffusive equations with the contributions from spin-dependent surface screening ands spin-dependent conductivity. We show for MgO-Cu-Co-MgO system that the spin-dependent screening in thin Co film produces spin accumulation 7 times higher than that obtained by the spin-dependent conductivity in thick Co films. We propose an experimental approach to validate our numerical predictions and to distinguish between spin accumulation induced by the spin-dependent conductivity and by the spin-dependent surface screening.
The MUSE view of He 2-10: no AGN ionization but a sparkling starburst

We study the physical and dynamical properties of the ionized gas in the prototypical HII galaxy Henize 2-10 using MUSE integral field spectroscopy. The large scale dynamics is dominated by extended outflowing bubbles, probably the results of massive gas ejection from the central star forming regions. We derive a mass outflow rate dMout/dt~0.30 Msun/yr, corresponding to mass loading factor eta~0.4, in range with similar measurements in local LIRGs. Such a massive outflow has a total kinetic energy that is sustainable by the stellar winds and Supernova Remnants expected in the galaxy. We use classical emission line diagnostic to study the dust extinction, electron density and ionization conditions all across the galaxy, confirming the extreme nature of the highly star forming knots in the core of the galaxy, which show high density and high ionization parameter. We measure the gas phase metallicity in the galaxy taking into account the strong variation of the ionization parameter, finding that the external parts of the galaxy have abundances as low as 12 + log(O/H)~8.3, while the central star forming knots are highly enriched with super solar metallicity. We find no sign of AGN ionization in the galaxy, despite the recent claim of the presence of a super massive active Black Hole in the core of He~2-10. We therefore reanalyze the X-ray data that were used to propose the presence of the AGN, but we conclude that the observed X-ray emission can be better explained with sources of a different nature, such as a Supernova Remnant.
An example of degenerate hyperbolicity in a cellular automaton with 3 states

We show that a behaviour analogous to degenerate hyperbolicity can occur in nearest-neighbour cellular automata (CA) with three states. We construct a 3-state rule by "lifting" elementary CA rule 140. Such "lifted" rule is equivalent to rule 140 when arguments are restricted to two symbols, otherwise it behaves as identity. We analyze the structure of multi-step preimages of 0, 1 and 2 under this rule by using minimal finite state machines (FSM), and exploit regularities found in these FSM. This allows to construct explicit expressions for densities of 0s and 1s after $n$ iterations of the rule starting from Bernoulli distribution. When the initial Bernoulli distribution is symmetric, the densities of all three symbols converge to their stationary values in linearly-exponential fashion, similarly as in finite-dimensional dynamical systems with hyperbolic fixed point with degenerate eigenvalues.
Single-particle versus pair condensation of hard-core bosons with correlated hopping

We investigate the consequences of correlated hopping on the ground state properties of hard-core bosons on a square lattice as revealed by extensive exact diagonalizations and quantum Monte Carlo simulations. While for noninteracting hard-core bosons the effective attraction induced by the correlated hopping leads to phase separation at low density, we show that a modest nearest-neighbor repulsion suppresses phase separation, leading to a remarkable low-density pairing phase with no single particle Bose-Einstein condensation but long-range two-particle correlations, signaling a condensation of pairs. We also explain why the unusual properties of the pairing phase are a real challenge for standard one-worm quantum Monte Carlo simulations.
Hubble Space Telescope Imaging of the Ultra-compact High Velocity Cloud AGC 226067: A Stripped Remnant in the Virgo Cluster

We analyze the optical counterpart to the ultra-compact high velocity cloud AGC 226067, utilizing imaging taken with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. The color–magnitude diagram of the main body of AGC 226067 reveals an exclusively young stellar population, with an age of ∼7–50 Myr, and is consistent with a metallicity of [Fe/H] ∼ −0.3 as previous work has measured via H ii region spectroscopy. Additionally, the color–magnitude diagram is consistent with a distance of D ≈ 17 Mpc, suggesting an association with the Virgo cluster. A secondary stellar system located ∼1. ′6 (∼8 kpc) away in projection has a similar stellar population. The lack of an old red giant branch (≳5 Gyr) is contrasted with a serendipitously discovered Virgo dwarf in the ACS field of view (Dw J122147+132853), and the total diffuse light from AGC 226067 is consistent with the luminosity function of the resolved ∼7–50 Myr stellar population. The main body of AGC 226067 has a MV = −11.3 ± 0.3, or Mstars = 5.4 ± 1.3 × 104 M⊙ given the stellar population. We searched 20 deg2 of imaging data adjacent to AGC 226067 in the Virgo Cluster, and found two similar stellar systems dominated by a blue stellar population, far from any massive galaxy counterpart—if this population has star-formation properties that are similar to those of AGC 226067, it implies ∼0.1 M⊙ yr−1 in Virgo intracluster star formation. Given its unusual stellar population, AGC 226067 is likely a stripped remnant and is plausibly the result of compressed gas from the ram pressure stripped M86 subgroup (∼350 kpc away in projection) as it falls into the Virgo Cluster.
RSVG: Exploring Data and Models for Visual Grounding on Remote Sensing Data

In this article, we introduce the task of visual grounding for remote sensing data (RSVG). RSVG aims to localize the referred objects in remote sensing (RS) images with the guidance of natural language. To retrieve rich information from RS imagery using natural language, many research tasks, such as RS image visual question answering, RS image captioning, and RS image–text retrieval, have been investigated a lot. However, the object-level visual grounding on RS images is still underexplored. Thus, in this work, we propose to construct the dataset and explore deep learning models for the RSVG task. Specifically, our contributions can be summarized as follows. First, we build the new large-scale benchmark of RSVG based on detection in optical remote sensing (DIOR) dataset, termed DIOR-RSVG, to fully advance the research of RSVG. This new dataset includes image/expression/box triplets for training and evaluating visual grounding models. Second, we benchmark extensive state-of-the-art (SOTA) natural image visual grounding methods on the constructed DIOR-RSVG dataset, and some insightful analyses are provided based on the results. Third, a novel transformer-based multigranularity visual language fusion (MGVLF) module is proposed. Remotely sensed images are usually with large-scale variations and cluttered backgrounds. To deal with the scale-variation problem, the MGVLF module takes advantage of multiscale visual features and multigranularity textual embeddings to learn more discriminative representations. To cope with the cluttered background problem, MGVLF adaptively filters irrelevant noise and enhances salient features. In this way, our proposed model can incorporate more effective multilevel and multimodal features to boost performance. This work can provide useful insights for developing better RSVG models.
A Comparative Qualitative and Quantitative Analysis of the Performance of Security Options for Message Protocols: Fog Computing Scenario

We analyze the utilization of publish-subscribe protocols in IoT and Fog Computing and challenges around security configuration, performance, and qualitative characteristics. Such problems with security configuration lead to significant disruptions and high operation costs. Yet, These issues can be prevented by selecting the appropriate transmission technology for each configuration, considering the variations in sizing, installation, sensor profile, distribution, security, networking, and locality. This work aims to present a comparative qualitative and quantitative analysis around diverse configurations, focusing on Smart Agriculture's scenario and specifically the case of fish-farming. As result, we applied a data generation workbench to create datasets of relevant research data and compared the results in terms of performance, resource utilization, security, and resilience. Also, we provide a qualitative analysis of use case scenarios for the quantitative data produced. As a contribution, this robust analysis provides a blueprint to decision support for Fog Computing engineers analyzing the best protocol to apply in various configurations.