Miracle-dz/UniFAR-FTUs huggingface dataset:
Macrophage polarization in spondyloarthritis

Introduction : Synovial tissue macrophages play a key role in chronic inflammatory arthritis, but the contribution of different macrophage subsets in this process remains largely unknown. The main in vitro polarized macrophage subsets are classically (M1) and alternatively (M2) activated macrophages, the latter comprising interleukin (IL)-4 and IL-10 polarized cells. Here, we aimed to evaluate the polarization status of synovial macrophages in spondyloarthritis (SpA) and rheumatoid arthritis (RA). Methods: Expression of polarization markers on synovial macrophages, peripheral blood monocytes, and in vitro polarized monocyte-derived macrophages from SpA versus RA patients was assessed by immunohistochemistry and flow cytometry, respectively. The polarization status of the intimal lining layer and the synovial sublining macrophages was assessed by double immunofluorescence staining. Results: The expression of the IL-10 polarization marker cluster of differentiation 163 (CD163) was increased in SpA compared with RA intimal lining layer, but no differences were found in other M1 and M2 markers between the diseases. Furthermore, no significant phenotypic differences in monocytes and in vitro polarized monocyte-derived macrophages were seen between SpA, RA, and healthy controls, indicating that the differential CD163 expression does not reflect a preferential M2 polarization in SpA. More detailed analysis of intimal lining layer macrophages revealed a strong co-expression of the IL-10 polarization markers CD163 and cluster of differentiation 32 (CD32) but not any of the other markers in both SpA and RA. In contrast, synovial sublining macrophages had a more heterogeneous phenotype, with a majority of cells co-expressing M1 and M2 markers. Conclusion: The intimal lining layer but not synovial sublining macrophages display an IL-10 polarized-like phenotype, with increased CD163 expression in SpA versus RA synovitis. These differences in the distribution of the polarized macrophage subset may contribute to the outcome of chronic synovitis.
A PERVASIVELY THINNER NEOCORTEX IS A TRANSDIAGNOSTIC FEATURE OF GENERAL PSYCHOPATHOLOGY

Objective. — Neuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the structural brain correlates of mental disorders mirrors already well-documented phenotypic comorbidity of psychiatric symptoms and diagnoses, which can be indexed by a general psychopathology or p factor. We hypothesized that if general psychopathology drives the convergence of structural alterations common across disorders then 1) there should be few associations unique to any one diagnostic family of disorders, and 2) associations with the p factor should overlap with those for the broader diagnostic families. Methods. — Analyses were conducted on structural MRI and psychopathology data collected from 861 members of the population representative Dunedin Study at age 45. Results. — Study members with high scores across three broad diagnostic families of disorders (Externalizing, Internalizing, Thought Disorder) exhibited highly overlapping patterns of reduced global and widely distributed parcel-wise neocortical thickness. Study members with high p factor scores exhibited patterns of reduced global and parcel-wise neocortical thickness nearly identical to those associated with the three broad diagnostic families. Conclusions. — A pattern of pervasively reduced neocortical thickness appears common across all forms of mental disorders and may represent a transdiagnostic feature of general psychopathology. As has been documented with regard to symptoms and diagnoses, the underlying brain structural correlates of mental disorders may not exhibit specificity, the continued pursuit of which may limit progress toward more effective strategies for etiological understanding, prevention, and intervention.
ixabepilone as monotherapy or in combination for the treatment of advanced breast cancer

: Advanced breast cancer represents a therapeutic challenge for oncologists. Chemotherapy with anthracyclines and taxanes has improved survival in this setting, but resistant and refractory disease is common. Ixabepilone, an epothilone, is a recently approved chemotherapeutic agent, both as a single agent and in combination with capecitabine, with efficacy in patients with resistant advanced disease. In this review, the distinctive properties of this drug are discussed, as well as the clinical evidence of efficacy. Ongoing clinical trials are exploring the role of ixabepilone in several clinical settings: neoadjuvant, adjuvant, and novel combinations.
Effect of Educational Guidelines on Nurses’ Performance regarding Caring of Patients with An Intra-Aortic Balloon Pump

Background: Intra-aortic balloon pump (IABP) is the simplest, most cost-effective, easy to implant, and explant in the coronary catheterization laboratory by an interventional cardiologist and can effectively be managed in an intensive care unit. Aim: To evaluate the effect of educational guidelines on nurses’ performance regarding caring for patients with an intra-aortic balloon pump. Method: A quasi-experimental, pre and post-test intervention research design was implemented to conduct the current study. The study was conducted in the Cardio-Thoracic unit at Benha University. In addition, open-heart units at Nasser Institute Hospitals, Egypt. A convenience sample of all available nurses (64) (23 at Benha University & 41 at Nasser Institute Hospitals). Tools: Two tools were used to collect data: (I) A Pre-designed Questionnaire Sheet consisted of two parts (II) Nurses' Observational checklist for intra-aortic balloon pump care. Results: Showed the studied nurses' total knowledge about caring for patients with an intra-aortic balloon pump, 62.5% of nurses had an unsatisfactory level of total knowledge to be satisfactory during immediate and two months post guidelines implementation among 89.1% & 81.2%, respectively, while 67.2% of nurses had an incompetent level of total practice to be competent during immediate and two months post guidelines implementation among 92.2% & 79.7%, respectively and there was a highly statistically significant positive correlation between total knowledge and total practice at the post and follow up guidelines implementation. Conclusion: there was a statistically significant improvement in nursing performance regarding caring for patients with an intra-aortic balloon pump immediately after & 2 months post-guidelines implementation compared to pre-guidelines implementation. Recommendations: Improve the Practices of intensive care unit nurses through continuing educational sessions about intra-aortic balloon pumps to update their knowledge and practice.
POEMMA: Probe Of Extreme Multi-Messenger Astrophysics

The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) mission is being designed to establish charged-particle astronomy with ultra-high energy cosmic rays (UHECRs) and to observe cosmogenic tau neutrinos (CTNs). The study of UHECRs and CTNs from space will yield orders-of-magnitude increase in statistics of observed UHECRs at the highest energies, and the observation of the cosmogenic flux of neutrinos for a range of UHECR models. These observations should solve the long-standing puzzle of the origin of the highest energy particles ever observed, providing a new window onto the most energetic environments and events in the Universe, while studying particle interactions well beyond accelerator energies. The discovery of CTNs will help solve the puzzle of the origin of UHECRs and begin a new field of Astroparticle Physics with the study of neutrino properties at ultra-high energies.
The cydR gene product , required for regulation of cytochrome 6 d expression in the obligate aerobe Azotobacter vinelandii , is an Fnr-like protein

Laboratory, John lnnes Centre, Colney, Norwich NR4 7UH, UK 2 Nitrogen Fixation The cytochrome bd complex in the obligately aerobic diazotroph Azotobacter vinelandii is an oxidase, which, in wiwo, has a low affinity for oxygen and is required for respiratory protection of nitrogenase. Mutations caused by insertion of Tn5-B20 upstream of the structural genes (CydAB) for cytochrome bd result in over-expression of this oxidase and, for unexplained reasons, inability of the organism to grow microaerobically. Cloning and sequencing of this upstream region revealed a gene, cydR. The deduced amino acid sequence of CydR indicates that it is a new member of the Fnr class of regulators and that it represses cydAB expression. Refined mapping data for three insertions in cydR are presented. The cloned cydR gene complemented anaerobic growth of Escherichis coli fnr mutants and strongly enhanced expression of a narG-lacZ fusion in an E. coli fnr mutant.
The Effect of Perceived Organizational Support and Employee Care on Turnover Intention and Work Engagement: A Mediated Moderation Model Using Age in the Post Pandemic Period

The purpose of this study was to adopt the well-established and mature job demands–resources model (JD-R), and to extend its model to work engagement and turnover intention of frontline healthcare personnel. Using the cross-sectional survey and partial least squares path modeling tools, the results showed that perceived organizational support had a negative impact on the turnover intention of frontline healthcare staff. This finding is important because it shows how the medical system managers can buffer the negative impact of a lack of job resources on the work engagement of employees in terms of personal strategies, such as the psychological pressure in coping with a high workload. Compared with employee care, perceived organizational support for the respondents had a positive impact on work engagement, whereas work engagement had a negative impact on turnover intention. This study successfully integrated the literature on job resources, work engagement, and turnover intention to determine the real needs of frontline medical personnel.
interferon-free combination therapies for the treatment of hepatitis C: current insights

: The hepatitis C virus (HCV) treatment landscape has rapidly changed over the past 5 years. The development of direct-acting antiviral (DAA) agents that specifically target various steps in the HCV lifecycle has revolutionized therapeutic options for patients with HCV, with the development of highly effective and well-tolerated oral interferon-free regimens. There are many DAAs that are currently in development or have recently been approved, which target different nonstructural HCV proteins and host targets that are essential for HCV replication. This review will focus on the different classes of DAAs and the various combinations that are in advanced development for the treatment of chronic HCV infection and will focus on the different regimens Investigation treatment hepatic disease; used the treatment of hepatic disease. Issues and
Nonadherence in difficult asthma – facts, myths, and a time to act

: Nonadherence to prescribed treatment is an important cause of difficult asthma. Rates of nonadherence amongst asthmatic patients have been shown to range between 30% and 70%. This is associated with poor health care outcomes and increased health care costs. There is no such thing as a “typical” nonadherent patient. The reasons driving nonadherence are multifactorial. Furthermore, adherence is a variable behavior and not a trait characteristic. Adherence rates can vary between the same individual across treatments for different conditions. There is no consistent link between socioeconomic status and nonadherence, and although some studies have shown that nonadherence is more common amongst females, this is not a universal finding. The commonly held perception that better adherence is driven by greater disease severity has been demonstrated to not be the case, in both pediatric and adult patients. Identification of nonadherence is the first step. If adherence is not checked, it is likely that poor adherence will be labeled as refractory disease. Failure to identify poor adherence may lead to inappropriate escalation of therapy, including the potential introduction of complex biological therapies. Surrogate measures, such as prescription counting, are not infallible. Nonadherence can be difficult to identify in clinical practice, and a systematic approach using a variety of tools is required. Nonadherence can be successfully addressed. Therefore, assessment of adherence is of paramount importance in difficult asthma management, in order to reduce exacerbations and steroid-related side effects as well as hospital and intensive care admissions, health care cost, and inappropriate treatment escalation. In this paper, we present an overview of the literature surrounding nonadherence in difficult asthma. We explore the facts and myths surrounding the factors driving nonadherence as well as how it can be identified and addressed. and documented compliance with inhaled high-dose corticosteroids, long-acting beta-2 agonists, leukotriene receptor antagonists, theophyllines, oral corticosteroids, and smoking cessation if clinically appropriate. 45
Fetal RHD Genotyping Using Maternal Plasma Effective : August 1 , 2017

PLEASE NOTE: Contracts exclude from coverage, among other things, services or procedures that are considered investigational or cosmetic. Providers may bill members for services or procedures that are considered investigational or cosmetic. Providers are encouraged to inform members before rendering such services that the members are likely to be financially responsible for the cost of these services.
Burden of Methicillin‐Resistant Staphylococcus aureus: Focus on Clinical and Economic Outcomes

Infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) are a major public concern. Hospital‐acquired MRSA rates have steadily increased over the past 25 years, and the bacterial strain is making inroads to the community. The morbidity and mortality burden of MRSA infection is compounded by delayed or inappropriate antibiotic treatment, taking a toll on health care resources that are already stretched thin. Vancomycin has historically been the drug of choice for this pathogen because its broad spectrum can address the multidrug resistance of most MRSA infections. Despite its sustained in vitro microbiologic inhibitory activity, researchers are beginning to question the continued utility of vancomycin for MRSA infections. Evidence against vancomycin is most notable with regard to nosocomial pneumonia and skin and soft tissue infections. In addition, because vancomycin must be administered intravenously, patients typically require prolonged hospitalization, which further increases the cost of MRSA treatment and exposes patients to additional nosocomial infections. Recent studies have shown that antibiotics with good bioavailability, such as linezolid, can be given orally to facilitate early hospital discharge, thus alleviating the economic burden of MRSA infections. Several agents have been developed over the past decade that have excellent in vitro activity against MRSA. Further studies are needed to determine if these drugs can better eradicate MRSA than vancomycin and remedy the adverse outcomes frequently observed with this organism.
Re-Os dating of Mo-bearing black shale of the Laoyaling deposit, Tongling, Anhui Province, China

Laoyaling is a typical stratiform deposit in the Tongling district and the molybdenum orebody is hosted by black shale of the Dalong Formation of the Upper Permian system. Eight black shale samples from the Laoyaling Mo orebody were dated by Re-Os technique using ICP-MS,which give an isochron age of 234.2±7.3 Ma with an initial ^187Os/^188 Os ratio of 1.37±0.39. The apparent Re-Os age is a few million years younger than the depositional age of the Late Permian. The young isochron age may be caused by the later hydrothermal disturbance or mass fractionation during ICP-MS measurement. However, the obtained isochron age is close to the depositional age and far earlier than those of the Late Yanshanian intrusions. It suggests that the Mo ore of the Laoyaling deposit is sedimentary in origin and not related to the Late Yanshanian magmatism. Black shales of the Upper Permian are distributed widely in the Mid-Lower Yangtze region, our result is important for understanding the ore-forming processes in the region and broadens the exploration target.
Impacts of anthropogenic aerosol and greenhouse gas emissions on clouds, convection, and precipitation as simulated by a super-parameterized global climate model

Clouds strongly influence Earth's climate by reflecting and absorbing radiation, transporting latent heat, and generating precipitation. Changes in cloud properties in response to anthropogenic greenhouse gas and aerosol particle emissions can both dampen and amplify climate trends. Conventional global climate models (GCMs) poorly represent the multi-scale nature of these processes, which range from micrometer-scale droplet nucleation to large- scale convective systems, and thus contribute significant uncertainty to future projections. A new approach called super-parameterization replaces conventional statistical parameterizations with embedded cloud-resolving models that explicitly simulate sub-grid convection. A super- parameterized version (SPCAM) of the standard Community Atmosphere Model (CAM) is shown to improve the variability and intensity of simulated convection, and representation of aerosol-cloud interactions. Natural modes of variability influence aerosol and cloud distributions such that isolating statistically significant aerosol indirect effects requires long simulations. SPCAM improves aerosol- cloud relationships compared to conventional GCMs, but the added computational cost of resolving convection makes long integrations prohibitively expensive. An alternative Newtonian relaxation approach applied here uses nudging to constrain simulations with pre-industrial and present-day aerosol emissions toward identical meteorology. This reduces differences in natural variability and dampens feedbacks to isolate aerosol indirect forcing estimates from short simulations. Nudging facilitates a meaningful evaluation of one-year SPCAM simulations, which produce a substantially weaker indirect effect (-0.81 Wm⁻²) than CAM (-1.19 Wm⁻²). Most GCMs do not realistically represent the physical mechanisms that generate convection in the Central US during summer, and models disagree on the sign of future precipitation trends. A realistic convection signal in a climate change-capable GCM has recently been documented in SPCAM. A new empirical orthogonal function- based index developed here efficiently demonstrates that nocturnal, eastward propagating mesoscale convective systems are a robust effect of super-parameterization. The signal is sensitive to aspects of model implementation and is most realistic in the latest version. Employing a time- slice climate change experiment design, Central US convection is further shown to be sensitive to higher CO₂ concentrations, which increase the intensity of precipitation generated by propagating storms. Changes in these storms are one manifestation of the general shift toward more extreme rainfall captured in SPCAM, but not in CAM
Wildlife in Lao PDR : 1999 status report

Compiles recent data and reviews past information to provide annotated species lists of all amphibians, reptiles, birds and mammals of Lao People's Democratic Republic. Each species account considers seasonal status, distribution in the country, altitude range, and habitats used. Species of national conservation concern are identified and the account is expanded to a synthesis of recent and historical status information. The issues are summarised for taxa considered under several names in recent sources. The introduction covers information sources, geography and biogeography, human use of wildlife in the country, current conservation initiatives and recommendations for future activities
Factors Inﬂuence Satisfaction and Continuance Intention of Chatbot Users

The pandemic has led to increased penetration in the digitalization sector, one of which is online shopping. The increase in online shopping activities poses challenges for businesses serving consumers, especially customer service. In this situation, chatbots can be a solution to provide better service to consumers. Satisfaction and continuance intention of a chatbot is important variables because they relate to several desired outcomes by businesses. Information System Success (ISS) Model, Technology Acceptance Model (TAM), and Expectation-Conﬁrmation Model (ECM) are combined. Using the SEM-PLS method on 210 respondents’ data collected concluded that satisfaction was signiﬁcantly inﬂu-enced by conﬁrmation of expectations, perceived ease of use and enjoyment. Meanwhile, satisfaction, perceived enjoyment and usefulness signiﬁcantly inﬂu-ence continuance intention. This research contributes in several ways related to the understanding of chatbot users in Indonesia and how to improve the experience based on the ﬁndings.
Clinical characteristics of COVID-19 patients admitted to Intensive Care Unit in Panama during the first pandemic wave admissions in 2020.

The severe acute respiratory syndrome Coronavirus 2 (SARS COV-2) caused a global pandemic of COVID-19. Most of people affected are admitted to hospital with various grades of ADRS. A small proportion of these patients requires intensive care unit management and treatment. However not all of them survive. This study aims to describe the epidemiological and clinical characteristics of patients admitted to the intensive care units in Panama main hospital in the first six months of pandemic with available information. Special focus has been oriented to blood and respiratory biomarkers to correlate with survivors and non-survivors. Our results show that patients between 56-75 years old, with hypertension, obesity, and diabetes comorbid conditions are more likely to die in intensive care units. Regarding the PaFi ratio, we observed a greater proportion of non-survivor with values less than 200. The triglycerides, urea nitrogen, creatinine and procalcitonin levels resulted significantly higher in those non survivors. During clinical management, half of patient that were administered Tocilizumab did not survived. These results support the notion that age, comorbidities as well as therapeutic management of patient in intensive care units contribute to the final outcome. We recommend reinforcing patient care strategy, especially in those patients with clinical conditions that favor fatal outcomes.
Sur les représentations unitaires des groupes de Lie nilpotents. II

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Mining, sex work and STIs: why force a connection?

Can the mining boom be blamed for the rising rates of sexually transmitted infections (STIs) in some states? The Australian Medical Association thinks so, with its Queensland president Dr Richard Kidd attributing rising rates of gonorrhoea, syphilis and chlamydia in Queensland and Western Australia to bored and cashed-up miners.
Statistica Sinica Preprint

: We develop measures of uncertainty, including model conﬁdence sets and a LogP measure, for shrinkage model selection procedures. The measures are developed for linear models, generalized linear models, and generalized additive models. We study the theoretical and empirical properties of the proposed measures, and demonstrate how theses measures by applying them to real-life problems.