Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis

Fibrinogen-like 2 (FGL2) was recently found to be associated with fibrosis in a mouse model of kidney damage and was proposed as a potential therapeutic target in chronic kidney disease (CKD). We assessed the association of renal FGL2 mRNA expression with the disease outcome in two independent CKD cohorts (NEPTUNE and Innsbruck CKD cohort) using Kaplan Meier survival analysis. The regulation of FGL2 in kidney biopsies of CKD patients as compared to healthy controls was further assessed in 13 human CKD transcriptomics datasets. The FGL2 protein expression in human renal tissue sections was determined via immunohistochemistry. The regulators of FGL2 mRNA expression in renal tissue were identified in the co-expression and upstream regulator analysis of FGL2-positive renal cells via the use of single-cell RNA sequencing data from the kidney precision medicine project (KPMP). Higher renal FGL2 mRNA expression was positively associated with kidney fibrosis and negatively associated with eGFR. Renal FGL2 mRNA expression was upregulated in CKD as compared with healthy controls and associated with CKD progression in the Innsbruck CKD cohort (p-value = 0.0036) and NEPTUNE cohort (p-value = 0.0048). The highest abundance of FGL2 protein in renal tissue was detected in the thick ascending limb of the loop of Henle and macula densa, proximal tubular cells, as well as in glomerular endothelial cells. The upstream regulator analysis identified TNF, IL1B, IFNG, NFKB1, and SP1 as factors potentially inducing FGL2-co-expressed genes, whereas factors counterbalancing FGL2-co-expressed genes included GLI1, HNF1B, or PPARGC1A. In conclusion, renal FGL2 mRNA expression is elevated in human CKD, and higher FGL2 levels are associated with fibrosis and worse outcomes.
Numerical Simulation of the Life Cycle of Tropical Cyclones

Abstract The tropical cyclone is a solitary creature of the tropical oceans accompanied by violent rotating winds and torrential rain. Observational studies and diagnostic analyses leave little doubt that the energy required for driving the vortex comes from the latent heat of condensation released by tall convective clouds around the center, and that the frictionally induced inflow in the vortex plays a major role in supporting the continued activity of convective clouds. This dual character with respect to important scales of motion poses a great difficulty in investigating the dynamics of tropical cyclones as time-dependent phenomena. However, in order to understand the large-scale aspects of tropical cyclones, one may formulate the role of convective clouds in terms of cyclone-scale variables with only implicit consideration of the dynamics of individual clouds. The present study is an attempt to understand the basic mechanism of tropical cyclones by constructing a numerical-dynamical model on such a .
Numerical simulation of VLF risers, fallers, and hooks observed in Antarctica

The VLF database from Halley station, Antarctica, has been searched, and prominent examples of discrete emissions are presented. Risers, fallers, quasiconstant tones, and upward and downward hooks are all common. Also observed are risers and fallers triggered from the tops of hiss bands. A one-dimensional Vlasov VHS code has been used to simulate the main types of events observed. Using realistic plasma parameters, the code successfully reproduces the main kinds of events observed, in good qualitative agreement with observations. Distinct generation region structures are found to be associated with risers and fallers. Hook formation is interpreted as being a spontaneous transition between these two quasi-stable generation region structures.
A Study of the Energetics of African Easterly Waves Using a Regional Climate Model

Abstract The evolution and spatial distribution of the energetics of African waves are studied. Complete eddy energy equations for an open system are derived for the computation of energy transformations during wave generation and dissipation. It is found that baroclinic overturning is the dominant energy source, although barotropic conversions can be almost equally important when there is concentrated moist convection south of the jet or shallow cumulus convection beneath the jet. The generation of active waves usually results from the nearly in-phase evolution of baroclinic and barotropic conversions, which are associated with significant rainfall over Africa. Significant barotropic instability associated with the horizontal shear is usually induced by concentrated deep convection on the southern flank of the jet. Barotropic conversions associated with the vertical wind shear may attain even greater magnitudes than that associated with the horizontal shear when shallow cumulus convection beneath the jet.
Continuum Mechanics and Applications in Geophysics and the Environment

I Applied Continuum Mechanics. - Numerical Investigation of Shock Waves in a Radiating Gas Described by a Variable Eddington Factor. - Anisotropic Fluids: From Liquid Crystals to Granular Materials. - Integration and Segregation in a Population - A Thermodynamicists's View. - Asymptotic and Other Properties of Some Nonlinear Diffusion Models. - The Binary Mixtures of Euler Fluids: A Unified Theory of Second Sound Phenomena. - Continuously Distributed Control of Plates by Electric Networks with PZT Actuators. - II Soil Mechanics and Porous Media. - Hydraulic Theory for a Frictional Debris Flow on a Collisional Shear Layer. - The Beavers and Joseph Condition for Velocity Slip at the Surface of a Porous Medium. - Porous Convection, the Chebyshev Tau Method, and Spurious Eigenvalues. - Mechanics of Multiphase Porous Media - Application to Unsaturated Soils. - III Glacier and Ice Dynamics. - Modelling Iceberg Drift and Ice-Rafted Sedimentation. - Modelling the Flow of Glaciers and Ice Sheets. - Notes on Basic Glaciological Computational Methods and Algorithms. - Constitutive Modelling and Flow Simulation of Anisotropic Polar Ice. - Influence of Bed Topography on Steady Plane Ice Sheet Flow. - IV Climatology and Lake Physics. - Glacial Isostasy: Models for the Response of the Earth to Varying Ice Loads. - Arctic Sea Ice and Its Role in Climate Variability and Change. - The Role of Simple Models in Understanding Climate Change. - Comparing Different Numerical Treatments of Advection Terms for Wind-Induced Circulations in Lake Constance.
Relationship between Perceived Physical Competence and Outdoor Play among Children Aged 9–12 Years-Focused Sex-Specific Differences

Background: Outdoor play (OP), which is considered important for children’s development, is declining every year. Perceived physical competence (PPC) is a vital factor that promotes physical activity such as OP, sports clubs, etc., but the relationship between PPC and OP was unknown. The purpose of this research was to investigate the relationship between PPC and OP in children and consider whether there were any sex-specific changes. Methods: A cross-sectional study was conducted in Japan with 288 children (134 girls, age: 10.6 ± 1.01 years). OP was assessed using an original self-report questionnaire. Each weekday, the children reported the time of OP and were classified as “high” if they played outside for at least an hour three times. PPC was evaluated with a self-report questionnaire developed by Okazawa et al. (1996). It has 12 questions and was assessed on a 5-point Likert scale. After adjusting for age, sex, BMI, screen time, sports club participation, and the number of friends, logistic regression analyses were carried out. Results: Children with better PPC were significantly more likely to be classified as “high” [crude odds ratio (OR): 1.04; 95% confidence interval (CI): 1.00–1.08; adjusted OR: 1.04; 95% CI: 1.00–1.08]. Only girls with better PPC were significantly more likely to be classified as “high” in a sex-based stratified analysis [crude OR: 1.08; 95% CI: 1.01–1.15, adjusted OR 1.09; 95% CI: 1.02–1.17]. Conclusions: Particularly among girls, OP could be promoted as a voluntary physical activity with improved PPC.
Extended Social Cognitive Model Explains Pre-Service Teachers’ Technology Integration Intentions with Cross-Cultural Validity

Abstract Despite decades of efforts to address all levels of barriers, promoting technology integration in schools continues to be challenging and one of the most active research areas in teacher education worldwide. There is a need to better understand the factors influencing teachers’ intentions to integrate technology. Current models may lack parsimony and are limited in practical implications. Therefore, the primary purpose of the current study was to develop a new model by extending social cognitive theory. to explain pre-service teachers’ technology integration intentions and to test its cross-cultural validity with Turkish and Spanish pre-service teachers. The participants were 135 (76 Turkish and 59 Spanish) pre-service teachers in the early childhood education department. Path analysis results supported the utility of the model and revealed that openness, facilitating conditions, self-efficacy, and outcome expectations are interrelated, and each plays a unique and complex role in explaining technology integration intentions. More importantly, multi-group invariance analysis test results revealed that the proposed model explained pre-service teachers’ technology integration intentions in Turkish and Spanish samples with the exception of only one path, from openness to outcome expectations. The current extended social cognitive theory model is concise, includes pertinent constructs from other theoretical frameworks and models, and offers practical implications for teacher educators.
Unsteady analysis for oscillatory flow of magnetorheological fluid dampers based on Bingham plastic and Herschel–Bulkley models

It is known that a quasi-static analysis without considering fluid inertia is usually used for magnetorheological damper design. However, fluid inertia terms need to be incorporated into the governing Navier–Stokes equation in practical application for oscillatory or unsteady fluid flow. In this article, an unsteady flow of magnetorheological fluids within flow mode magnetorheological dampers was theoretically investigated under sinusoidal displacement excitation. Based on the governing Navier–Stokes equation, incorporating the boundary and initial conditions, central numerical velocity solutions of magnetorheological fluids within magnetorheological damping channel were developed and used to confirm the damping force using both Bingham plastic and Herschel–Bulkley models of magnetorheological fluids. To simplify the governing equation of Herschel–Bulkley flow, an approximation method replacing Herschel–Bulkley model velocity with Bingham plastic model velocity during calculating effective viscosity shear rate of Herschel–Bulkley model is proposed and used. For given magnetorheological fluid properties and flow mode magnetorheological damper geometry, under different yield stresses, sinusoidal excitation frequencies, and power-law exponent of Herschel–Bulkley model, the effects of magnetorheological fluid inertia terms on work and characteristic diagrams of magnetorheological dampers are discussed.
Strangers in my home: the 2015 refugee event in Europe and founder social identities of nascent entrepreneurs

ABSTRACT How does the grand challenge of refugees influence nascent entrepreneurs in host countries? To explore this question, we build on social identity theory and analyse how the 2015 European refugee event is related to the strength of different founder social identities (i.e. Darwinian, Communitarian, and Missionary founder social identities) of nascent entrepreneurs in the countries accommodating the refugees. Using a dataset of 6,096 nascent entrepreneurs from 24 European countries, we reveal a positive relationship between the refugee event and the strength of the Communitarian founder social identity. This relationship is even stronger when the previous percentage of foreign migrants in a country is lower and is mediated by the human health and social work industry. Interestingly, we do not find significant relationships between the refugee event and the strengths of the Darwinian or Missionary founder social identity, respectively. Hence, refugees as a grand challenge are likely to have divergent influences on different types of entrepreneurship in society.
Crystalline texture of cobalt nanowire arrays probed by the switching field distribution and FORC diagrams

The crystalline texture of arrays of low diameter Co nanowires (NWs) synthesized by electrodeposition using electrolytes with different acidities (pH in the range 2.0–6.6) was studied by the switching field distribution (SFD) and first order reversal curve (FORC) diagrams. Particularly, the SFD determined as the derivative dM/dH of the descending part of the major hysteresis loop has proven to be a reliable and powerful method for the identification of different crystalline textures in the NWs and the quantification of their corresponding texture percentages. The presence of the face centered cubic-like texture at low pH values and hexagonal close packed textures with the c-axis perpendicular and parallel to the NWs axis at higher pH values have been identified by performing multiple Gaussian fits to the SFD by virtue of their different magnetic behavior observed during reversal of the magnetization. The field position and size of each curve in the multiple Gaussian fit provide information about the corresponding magnetic contribution and volumetric texture percentage of each crystalline texture in the NWs, respectively. The analysis of the SFD has been complemented and validated with FORC diagram measurements, showing that the width of the coercive field distribution is in good agreement with the width of the SFD. Also, it has been found that the different branches observed in the FORC diagrams along the interaction axis provide further insight on the interaction between magnetocrystalline fields. This work provides a novel methodology for the use of magnetometry as a reliable technique for the study of the interplay between the microstructure and magnetic behavior of arrays of NWs.
A Simple Differential Microwave Imaging Approach for In-Line Inspection of Food Products

Microwave imaging has been recently proposed as alternative technology for in-line inspection of packaged products in the food industry, thanks to its non-invasiveness and the low-cost of the equipment. In this framework, simple and effective detection/imaging strategies, able to reveal the presence of foreign bodies that may have contaminated the product during the packaging stage, are needed to allow real-time and reliable detection, thus avoiding delays along the production line and limiting occurrence of false detections (either negative or positive). In this work, a novel detection/imaging approach meeting these requirements is presented. The approach performs the detection/imaging of the contaminant by exploiting the symmetries usually characterizing the food items. Such symmetries are broken by the presence of foreign bodies, thereby determining a differential signal that can be processed to reveal their presence. In so doing, the approach does not require the prior measurement of a reference, defect-free, item. With respect to the quite common case of homogeneous food packaged in circular plastic/glass jars, numerical analyses are provided to show the effectiveness of the proposed approach.
Strain state, microstructure and electrical transport properties of LaNiO3 films grown on Si substrates

LaNiO3 films with various thicknesses were deposited on Si substrates by sputtering. The film thickness dependent strain state, microstructure and electrical properties were investigated. X-ray diffraction analysis shows that the films are generally strained with larger lattice constants than the value for bulk LaNiO3, due to a large difference in thermal expansion coefficients between LaNiO3 and Si. However, with increasing film thickness, the internal strain is gradually relaxed with the lattice constant decreased and the crystallinity and electrical properties improved as well. The film thickness dependent resistivity can be quantitatively described by a combined Fuchs–Sondheimer and Mayadas–Shatzkes model, including both the grain boundary scattering and the surface scattering. Further low temperature resistivity measurement shows that the film of 600 nm is semiconducting. The higher activation energy acquired by the small polaron conduction fitting than by the Arrhenius fitting indicates relatively large effective masses for the polarons in the film.
Modulated, frequency-locked, and chaotic cross-waves

Measurements were made of the wave height of periodic, quasi-periodic, and chaotic parametrically forced cross-waves in a long rectangular channel. In general, three frequencies (and their harmonics) may be observed: the subharmonic frequency and two slow temporal modulations — a one-mode instability associated with streamwise variation and a sloshing motion associated with spanwise variation. Their interaction, as forcing frequency, f, and forcing amplitude, a, were varied, produced a pattern of Arnold tongues in which two or three frequencies were locked. The overall picture of frequency-locked and -unlocked regions is explained in terms of the Arnold tongues predicted by the circle-map theory describing weakly coupled oscillators. Some of the observed tongues are apparently folded by a subcritical bifurcation, with the tips of the tongues lying on the unstable manifold folded under the observed stable manifold. Near the intersection of the neutral stability curves for two adjacent modes, a standing wave localized on one side of the tank was observed in agreement with the coupled-mode analysis of Ayanle, Bernoff & Lichter (1990). At large cross-wave amplitudes, the spanwise wave structure apparently breaks up, because of modulational instability, into coherent soliton-like structures that propagate in the spanwise direction and are reflected by the sidewalls.
The Effect of Combination Of Progressive Muscle Relaxation And Nature Sound Music Therapy On Sleep Quality Of Menopaused Women

Background: Introduction. Menopause is a critical process that every woman will experience. Decreased function of female organs occurs because they cannot produce the hormones esterogen and progesterone, causing psychological and physiological symptoms. One of the physiological symptoms is sleep quality disorders, which if not handled properly will cause decreased concentratio, anxiety and stress. Pharmacological and non pharmacological theraphy to help postmenopausal women reduce their sleep disorders. The study aimed to determine the effect of combination therapy of progressive muscle relaxation and nature sound music therapy on sleep quality in postmenopause Methods: Quasy-Experiment research design. Population is menopause with a total of 220 people. The sample size is 102 respondents, the sampling is simple random sampling. The treatment group in combination therapy of progressive musc;e relaxation and nature sound music therapy 15-20 minutes; the control group was not given any intervention. The wariavle studied was the value of sleep quality obtained from the results of the questionaire(Pittsburgh Sleep Quality Index). The analysis used the Wilcoxon Signed Test for pre and post treatment and the Mann-Whitney test to determine the difference between the experimental group and the control group with a significant α <0,05. Results: The results of the sleep quality analysis using the Wilcoxon Signed Rank Test, p value 0,000 in the treatment group and p value 0,215 in the control group. The results of the analysis using the Mann-Whitney test obtained a p value of 0,000 on the value of sleep quality between the treatment group and the control group Conclusion: Combination therapy of progressive muscle relaxation and nature sound music therapy is effective for reducing the value of sleep quality disorders in menopausa women, ang this technique is easy to do, so it Can be applied as a nursing intervention at the puskesmas for the development of nursing knowledge in services
Aftershock fragility assessment of steel gabled frames consisting of web-tapered members

Due to the widespread construction of steel gabled frame systems throughout the world, many of them are located in regions with high seismicity and experience sequential strong events in the future. Previous studies have clearly shown that the damage caused by the mainshock modifies the overall strength and stiffness and consequently dynamic response to the aftershock. However, the current structural design process only considers the main seismic event, and the post-mainshock scenarios and their effects are generally ignored. In order to address this issue, in the present study, the mainshock incremental dynamic analysis (IDA) was first conducted on four SGFs. Then mainshock damage states based on the transient absolute maximum drift angle were considered, and aftershock incremental dynamic analysis analysis was performed on the mainshock-damaged structures. Aftershock fragility curves using probabilistic seismic demand models for transient absolute maximum drift angle and median IDA curves for residual absolute maximum drift angle were developed to compare intact and pre-damaged SGFs. The results showed that aftershocks significantly increase the vulnerability of short-period SGFs when higher damages are induced during mainshock, where the aftershock collapse capacity is reduced by up to 13% for the largest mainshock damage state. It was also found that in terms of aftershock collapse capacity associated with the residual absolute maximum drift angle, long-period SGFs require major realignment while short-period SGFs cannot be repaired.
Trauma Patients at Risk of In-Hospital Mortality

The trauma incidence in South Africa is significantly high and forms one of the top-five causes of unnatural death. Thus, one of the higher incidences of trauma across the world. Subsequently the in-hospital mortality forms a high burden of disease on the health systems in South African health care facilities. Therefore, analysing the incidence of trauma and the various mechanisms of trauma allows for in-hospital trauma mortalities to assessed. The aim of this study was to analyse the in-hospital mortality distribution factors at a Johannesburg Trauma unit over an eight-year retrospective review from 01 January 2005 –31 December 2012 and Analysis of Trauma Bank data forms at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Looking at demographics, physiological parameters, mechanism of Injury, Injury Severity Score (ISS) and New Injury Severity Score (NISS). Ethics through the Wits Ethics Committee was obtained. The Statistica V8 application was used to analyse the data that was collected and a P value of <0.05 was reported as significant. A total of 18, 087 Priority 1 patients were reviewed in this study. This sample demonstrated the 21-45 years of age group was the most affected trauma group (87.3%). Penetrating injuries (Stab and gunshot wounds) had the highest incidence yet lower mortalities. However, blunt injuries (ranging from Pedestrian- and Motor- vehicle crashes, blunt assaults, falls and burns) had lower incidences and higher mortalities. The highest in-hospital mortality was due to burns patients (22.56%) followed by pedestrian vehicle crashes patients affecting the predominantly young male population. Poor probability of survival was demonstrated amongst Motor Vehicle Crashes (Ps 44%) and Motorbike Crashes (34%), and PVCs.