Miracle-dz/UniFAR-FTUs huggingface dataset:
Adverse events following the first dose of ChAdOx1 nCoV-19 (COVISHIELD) vaccine in the first phase of vaccine roll out in Nepal

Introduction: Nepal started the first phase of COVID-19 vaccination for frontline healthcare workers in January 2021 with the ChAdOx1 nCoV-19 (COVISHIELD) vaccine. We conducted active surveillance of Adverse Effect Following Immunization (AEFI) after the first dose of the vaccine administered at one of the sentinel sites for vaccination, Patan Academy of Health Sciences (PAHS). Method: All the 5591 first dose ‘COVISHIELD’ vaccine recipients between 27 Jan -5 Feb 2021 at PAHS, were approached through phone calls to collect data on AEFI. Incidence of common AEFIs in different age groups, gender and those with previous history of COVID-19 were analyzed. Presence of any Adverse Events of Special Interest (AESI) were evaluated. Result: Out of 5591 vaccines recipient, 3991 (71.3%) responded to the phone call and AEFI was noted in 3394 (85.04%) of them. Minor AEFI was seen in 3391 (84.9%), severe Minor AEFI in 1 (0.02%) and Serious AEFI in 2 (0.05%). Out of 807 vaccine recipients with previous history of COVID-19, 709 (87.9%) had AEFI while of the 3184 with no past history of COVID-19, 2685 (84.3%) had AEFI. However, some of the systemic AEFIs were noted more frequently in those with past COVID-19 infection. A total of 1886 (55.6%) took self-medication for symptom relief, 278 (8.2%) took leave from work while 26 (0.76%) visited health facility for the AEFIs. Conclusion: Most AEFIs following the first dose of COVISHIELD vaccine were mild and resolved within a few days. Except for one case of anaphylaxis, no other AESI were encountered.
A new approach and gold standard toward author disambiguation in MEDLINE

OBJECTIVE Author-centric analyses of fast-growing biomedical reference databases are challenging due to author ambiguity. This problem has been mainly addressed through author disambiguation using supervised machine-learning algorithms. Such algorithms, however, require adequately designed gold standards that reflect the reference database properly. In this study we used MEDLINE to build the first unbiased gold standard in a reference database and improve over the existing state of the art in author disambiguation. MATERIALS AND METHODS Following a new corpus design method, publication pairs randomly picked from MEDLINE were evaluated by both crowdsourcing and expert curators. Because the latter showed higher accuracy than crowdsourcing, expert curators were tasked to create a full corpus. The corpus was then used to explore new features that could improve state-of-the-art author disambiguation algorithms that would not have been discoverable with previously existing gold standards. RESULTS We created a gold standard based on 1900 publication pairs that shows close similarity to MEDLINE in terms of chronological distribution and information completeness. A machine-learning algorithm that includes new features related to the ethnic origin of authors showed significant improvements over the current state of the art and demonstrates the necessity of realistic gold standards to further develop effective author disambiguation algorithms. DISCUSSION AND CONCLUSION An unbiased gold standard can give a more accurate picture of the status of author disambiguation research and help in the discovery of new features for machine learning. The principles and methods shown here can be applied to other reference databases beyond MEDLINE. The gold standard and code used for this study are available at the following repository: https://github.com/amorgani/AND/.
THE EFFECT OF ULIN (Eusideroxylon zwageri) STEM BARK EXTRACT ON THE GROWTH OF Candida albicans ON ACRYLIC RESIN DENTURE PLATES

ABSTRACT Background : Candida albicans is the main microorganism that causes denture stomatitis, thus denture soaking in cleansing solution is needed to protect them from Candida albicans contamination. The 0.2% Chlorhexidine gluconate is one of denture cleansers that induce side effects at prolonged use. An alternative ingredient that can be used as a denture cleanser is ulin stem bark extract. Objective: To determine the effect of ulin stem bark extract at 20%, 40%, 60%, 80%, 100% concentration on the growth of Candida albicans on acrylic resin denture plates. Method : True Experimental with post-test only with control group design was employed under 7 treatment groups consisting ulin stem bark extract at 20%, 40%, 60%, 80%, 100% concentration, 0.2% Chlorhexidine gluconate, and aquadest in a total of 28 samples. Acrylic resin samples that had been exposed to Candida albicans were soaked in respective treatment for 15 minutes. Results: The average of Candida albicans colonies on acrylic resin denture plates after soaking in ulin bark extract at 20%, 40%, 60%, 80%, 100% concentration, 0.2% Chlorhexidine gluconate, and aquadest were 29.5 CFU/ml, 13.0 CFU/ml, 0 CFU/ml, 0 CFU/ml, 0 CFU/ml, 0 CFU/ml, and 155 CFU/ml. Based on Mann Whitney test, there was no significant difference when ulin stem bark extract at 60% concentration was compared to 0.2% Chlorhexidine gluoconate. Conclusion: Ulin stem bark extract at 20%, 40%, 60%, 80%, and 100% concentration have been proven to reduce Candida albicans colonies on acrylic resin denture plates, and the 60% concentration is equivalent to 0.2% Chlorhexidine gluconate. Keywords: Candida albicans,Eusideroxylon zwageri, Heat cured acrylic resin. Ulin stem bark extract.
Seasonality and solar radiation variation level in benign paroxysmal positional vertigo

Abstract Background: Several studies have shown that the incidence of benign paroxysmal positional vertigo (BPPV) presents seasonal variations and there is evidence that the variation in time is dependent on the patient’s amount of vitamin D. Objectives: This is a retrospective study to verify if there is a correlation between the incidence of BPPV and the level of solar radiation, essential for the synthesis of vitamin D in the skin. Material and methods: This study comprised 214 patients with BPPV seen from 2012 to 2017, in a city Latitude: −30.0277, Longitude: −51.2287 30° 1′ 40″ South, 51° 13′ 43″ West. The amounts of monthly solar radiation were analyzed in relation to the dates of their first consultations. Statistical tests were employed to verify the existence of a correlation between solar radiation and the incidence of the disease. Results: The statistical analysis revealed a significant difference between the incidence of BPPV and the amount of radiation during the month of the diagnosis of the disease. There was also a significant statistical correlation with the climatic variation. Conclusion: More patients with benign paroxysmal positional vertigo (BPPV) are seen in consultation in the months with low solar radiation and in the autumn and winter seasons, in this geographic city.
A net-shape forming process of Ti–6Al–4V sphere joints

Near-net shape forming of the hollow sphere joints (60 mm in diameter) used in large space truss structure of spacecraft was realised by powder injection molding and diffusion bonding. For metal injection molding (MIM) process, two binder systems based on polyoxymethylene (POM) and paraffin wax (PW) are comparatively studied. The powder loading, power law index, viscous flow activation energy and integrated rheological factors of feedstock were systematically studied. Except powder loading, The feedstock based on POM system has a smaller strain and temperature sensitivity (n = 0.368, E = 17.95 kJ mol−1) and better rheological properties (α = 6.3). The lowest interstitials contents of as-sintered samples are 0.05 wt-% for C, 0.28 wt-% for O and 0.046 wt-% for N, which meet the Grade 5 PM (Ti–6Al–4V) specifications according to ASTM B988-13. The tensile strength and ductility reach 978 MPa and 6.3%, respectively, after 1300 °C sintering and capsule-free hot isostatic pressing (HIP).
Peak Age and Performance Progression in World-Class Weightlifting and Powerlifting Athletes.

PURPOSE The aim of this study was to quantify age of peak performance and performance improvements in the years preceding peak age in elite weightlifting and powerlifting athletes using results from powerlifting World Championships in 2003-2017 and weightlifting World Championships and Olympic Games in 1998-2017. METHODS Individual performance trends were derived by fitting a quadratic curve separately to each athlete's performance and age data. Effects were evaluated using magnitude-based inferences. RESULTS Peak age (mean ± SD) was 35 ± 7 y for powerlifters and 26 ± 3 y for weightlifters, a large most likely substantial difference of 9, ±1 y (mean, ±90% confidence limits). Men showed possibly higher peak age than women in weightlifting (0.8, ±0.7 y; small), and a possibly lower peak age in powerlifting (1.3, ±1.8 y; trivial). Peak age of athletes who ever won a medal was very likely less than that of non-medalists in weightlifting (1.3, ±0.6 y; small), while the difference in powerlifters was trivial but unclear. Five-year improvements prior to peak age were 12 ± 10% for powerlifters and 9 ± 7% for weightlifters, a small possibly substantial difference (2.9, ±2.1%). Women exhibited possibly greater improvements than men in powerlifting (2.7, ±3.8%; small) and very likely greater in weightlifting (3.5, ±1.6%; small). Medalists possibly improved less than non-medalists among powerlifters (-1.7, ±2.3%; small), while the difference was likely trivial for weightlifters (2.3, ±1.8%). CONCLUSIONS These novel insights on performance development will be useful for practitioners evaluating strategies for achieving success.
Field-based learning in global migrant health: An evaluation of student learning outcomes

ABSTRACT Increased migration and im/migrant (i.e. migrant and immigrant) inequities, particularly during COVID-19, call for experiential global public health teaching to adequately prepare future leaders. We evaluated student perspectives on the benefits, drawbacks, and lessons learned from a migrant health field course in the U.S.–Mexico border region. We analyzed qualitative data from reflexive diary-writing assignments and post-course evaluations from graduate and undergraduate students (N = 12). Students highlighted personal growth and reflexivity, professional development opportunities, and benefits and drawbacks of the immersive course design as key themes. Tri-national learning across Canada, Mexico and the U.S., and an interdisciplinary, cross-cultural learning model allowed for deeper understandings of globally relevant and politically and socially complex issues through community engagement and ‘real-world’ approaches. Students described benefits of reflexive learning, bridging classroom-based learning with field experiences, and learning about community-engaged research in advancing im/migrant justice, though acknowledged challenges of intensive course design. Narratives highlighted unique needs in navigating challenges inherent in reflexive learning on sensitive topics, such as structural inequities faced by asylum seekers. This evaluation provides unique empirical evidence to inform future experiential learning opportunities rooted in equity-oriented approaches, which are crucial for advancing hands-on learning regarding global issues. Appropriate approaches must ensure ethical, respectful community engagement and ongoing support for students.
Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson's Disease.

BACKGROUND DNA methylation studies in Parkinson's disease (PD) thus far have focused on disease susceptibility but not progression. OBJECTIVE In this epigenome-wide association study (EWAS), we aim to identify methylation markers associated with faster cognitive decline or motor progression in PD. METHODS We included 232 PD patients from the Parkinson's Environment and Gene follow-up study who provided blood samples at enrolment. Information on cognitive and motor function was collected using the Mini-Mental State Examination (MMSE) and Unified Parkinson's Disease Rating Scale (UPDRS). For EWAS analyses, we used a robust measure of correlation: biweight midcorrelations, t-tests, and Cox proportional hazard models. We also conducted weighted correlation network analysis (WGCNA) to identify CpG modules associated with cognitive decline or motor progression in PD. RESULTS Among 197 individuals of European ancestry, with our EWAS approach we identified 7 genome-wide significant CpGs associated with a MMSE 4-point decline and 8 CpGs associated with faster motor progression (i.e., rate of UPDRS increase ≥5-point/year). The most interesting CpGs for cognitive decline include cg17445913 in KCNB1 (cor = 0.36, p = 6.85×10-7) and cg02920897 in DLEU2 (cor = 0.34, p = 3.23×10-6), while for motor progression it was cg01754178 in PTPRN2 (cor = - 0.34, p = 2.07×10-6). In WGCNA, motor progression related modules were enriched for genes related to neuronal synaptic functions, Wnt signaling pathway, and mitochondrial apoptosis. CONCLUSIONS Our study provides the first epigenetic evidence that differential methylation in genes previously identified as being associated with cognitive impairment, neuronal synaptic function, Wnt signaling pathway, and mitochondrial apoptosis is associated with cognitive and motor progression in PD.
A Conceptual Model for Strategic Decision Making in Malaysian Third-Party Logistics Industry

The world economic is going through unpredictability and local reactions are not precluded. The growing demands of third-party logistics (3PL) users and the appearance of increased 3PL have generated aggressive conflict in the 3PL industry to engage with the user firms. This is essential for 3PL to assess their competitive strategies to stay resourceful parallel to their rivals. This article focuses on the assessment of internal resources and capabilities prior to the evaluation of competitive strategic decision taken by 3PL in Malaysia to achieve financial performance in the track of the world’s unpredictability. The firms’ strategic approach is low costs and / or differentiation according to the perspective of Resource-Based View (RBV) theory. The findings show that the functional involvement influences the low cost and marginally lead to differentiation strategy. The outputs show that the capability of IT has a positive and slight effect on the application of differentiation than the low-cost strategy. This article concludes with directions for practitioners, government and future research in leveraging resources and capabilities to achieve financial performance.
How website quality, service quality, perceived risk and customer satisfaction affects repurchase intension?: a case of Taobao online shopping

Using the questionnaire to collect the data on 252 customers by expressing their willingness to repurchase goods via Taobao website, we received their opinion and evaluation from the personal interview. Our results indicate the following findings: 1) The quality of the website on the shopping platform has a negative impact on customer's perceived risk. 2) The quality of online shopping website poses a positive effect on customer's satisfaction. 3) The quality of service provided within shopping website has a negative impact on perceived risk. 4) The quality of service on the shopping website platform has a positive impact on customer satisfaction. 5) The perceived risk on the shopping website has a negative impact on customer repurchase intention. 6) Customer satisfaction with the shopping website has a positive impact on customer repurchase intention.
Purcell’s Three-Link Swimmer: Assessment of Geometry and Gaits for Optimal Displacement and Efficiency

This paper studies the displacement and efficiency of a Purcell’s three-link microswimmer in low Reynolds number regime, capable of moving by the implementation of a motion primitive or gait. An optimization is accomplished attending to the geometry of the swimmer and the motion primitives, considering the shape of the gait and its amplitude. The objective is to find the geometry of the swimmer, amplitude and shape of the gaits which make optimal the displacement and efficiency, in both an individual way and combined (the last case will be referred to as multiobjective optimization). Three traditional gaits are compared with two primitives proposed by the authors and other three gaits recently defined in the literature. Results demonstrate that the highest displacement is obtained by the Tam and Hosoi optimal velocity gait, which also achieves the best efficiency in terms of energy consumption. The rectilinear and Tam and Hosoi optimal efficiency gaits are the second optimum primitives. Regarding the multiobjective optimization and considering the two criteria with the same weight, the optimum gaits turn out to be the rectilinear and Tam and Hosoi optimal efficiency gaits. Thus, the conclusions of this study can help designers to select, on the one hand, the best swimmer geometry for a desired motion primitive and, on the other, the optimal method of motion for trajectory tracking for such a kind of Purcell’s swimmers depending on the desired control objective.
Respon Anggrek Dendrobium sp., Oncidium sp., dan Phalaenopsis sp. Terhadap Pemberian Empat Jenis Nutrisi Organik yang Berbeda pada Tahap Regenerasi Planlet

Intan Dwi Ambarwati1, Firdha Narulita Alfian2, dan Parawita Dewanti3* 1Program Studi Agroteknologi, Fakultas Pertanian, Universitas Jember Jalan Kalimantan 37 Jember 68121 2Program Studi Magister Bioteknologi, Program Pascasarjana, Universitas Jember Jalan Kalimantan 37 Jember 68121 3Fakultas Pertanian, Universitas Jember, Jalan Kalimantan 37 Jember 68121 *Alamat korespondensi: parawita.faperta@unej.ac. id
LongShoT: Long-Range Synchronization of Time

Low-Power Wide Area Networks, such as LoRaWAN, are rapidly gaining popularity in the field of wireless sensing and actuation. While LoRaWan is heavily studied in applications and performance, the concept of time has rarely been characterized in such networks. Many applications will require synchronized local clocks with varying levels of precision in order to maintain consistency and coordination in the network. Traditional time synchronization protocols however do not fit LoRaWAN's delay-inherent, low duty cycle, network model and wide-area deployment topology. Meanwhile, relying on GPS for time is not an option for low-power applications. In this paper, we present LongShoT, a time synchronization scheme built on LoRaWan capable of synchronizing device clocks to within 10μs of a reference clock with a single network request. This is achieved by utilizing the deterministic properties of Lo-Ra Wan networks along with hardware- and MAC-level timestamping of packets. LongShoT was implemented on consumer off-the-shelf hardware and evaluated over physically distributed devices using GPS 1PPS as a reference. Our results show that LongShoT achieves an average synchronization error of less than 2μs and compensates oscillator drift to less than 0.1ppm with devices distributed within 4km of a gateway.
THE FOUR-FACTOR MODEL AND STOCK RETURNS IN BANGLADESH

For determining the expected return, and asset pricing, CAPM (Capital asset pricing model) is being used dominantly grounded on only the market (systematic) risk-factor though several anomalies have been revealed in this model. Fama and French (1993) have addressed those anomalies and developed the Three-factor model by combining size and value factors besides market factors. Over time, Carhart (1997) has further developed a model addressing momentum factor besides the three factors of Fama and French (1993) which is known as the Carhart four-factor model. Though several kinds of research have been conducted on the CAPM and three-factor model, little works have been accompanied by the Carhart four-factor model in an evolving market like Bangladesh. The goal of this work is to examine the validity of the Carhart four-factor model and examine the loftier explanatory power in Dhaka Stock Exchange (DSE). From the regression analysis of the Carhart model, we have found that market, size, value, and momentum explain the excess stock return. This study indicates that the Carhart model has the lowest GRS F-statistic, highest adjusted R-squared, and lowest Sharpe ratio in contrast to the CAPM and three-factor model which indicates the superior explanatory power and statistical validity of the Carhart model.
Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China

Genetic polymorphisms in numerous pharmacogenetics studies were regarded as the essential factors involved in the response to or metabolism of drugs. These genetic variants called very important pharmacogenetic (VIP) variants played a role in drugs metabolism, which have been summarized in the PharmGKB database. In this study, we genotyped 80 VIP variants from the PharmGKB in 100 members of Blang volunteers from Yunnan province.
Gravity wave instability structures and turbulence from more than one and a half years of OH* airglow imager observations in Slovenia

Abstract. We analysed 286 nights of data from the OH* airglow imager FAIM 3 (Fast Airglow IMager) acquired at Otlica Observatory (45.93 °N, 13.91 °E), Slovenia between 26 October 2017 and 6 June 2019. Measurements have been performed with a spatial resolution of 24 m/pixel and a temporal resolution of 2.8 s. A two-dimensional Fast Fourier transform is applied to the image data to derive horizontal wavelengths between 48 m and 4.5 km in the upper mesosphere / lower thermosphere (UMLT) region. In contrast to the statistics of larger scale gravity waves (horizontal wavelength up to ca. 50 km) we find a more isotropic distribution of directions of propagation, pointing to the presence of wave structures created above the stratospheric wind fields. A weak seasonal tendency of a majority of waves propagating eastward (westward) during winter (summer) may be due to secondary gravity waves originating from breaking primary waves in the stratosphere. We also observe an increased southward propagation during summer, which we interpret as an enhanced contribution of secondary gravity waves created as a consequence of primary wave filtering by the meridional mesospheric circulation. Furthermore, observations of turbulent vortices allowed the estimation of eddy diffusion coefficients in the UMLT from image sequences in 45 cases. Values range around 103–104 m2s-1 and mostly agree with literature. Turbulently dissipated energy is derived taking into account values of the Brunt-Väisälä frequency based on TIMED-SABER (Thermosphere Ionosphere Mesosphere Energetics Dynamics, Sounding of the Atmosphere using Broadband Emission Radiometry) measurements. Energy dissipation rates range between 0.63 W/kg and 14.21 W/kg leading to an approximated maximum heating of 0.2–6.3 K per turbulence event. These are in the same range as the daily chemical heating rates, which apparently stresses the importance of dynamical energy conversion in the UMLT.
Wernicke encephalopathy hearing loss and palinacousis

Wernicke encephalopathy (WE) is a neurological emergency that develops in the setting of thiamine deficiency, and is characterised by symptoms of confusion, ophthalmoplegia and gait ataxia. Less recognised signs and symptoms include vestibular dysfunction, hearing impairment, peripheral neuropathy, and in severe cases, coma. This case study describes a non‐alcoholic patient, who presents with significant auditory and vestibular changes in addition to the classic symptoms of WE. This case report describes a non‐alcoholic patient who developed deafness, severe horizontal canal paresis and symptoms of palinacousis in the setting of WE as a complication of a recent gastric sleeve operation.