Miracle-dz/UniFAR-FTUs huggingface dataset:
STUDY ON SOME AEROBIC BACTERIAL SPECIES IN ORNAMENTAL FISH

This study was performed to detect the presence of some microbes which cause diseases in ornamental fish, pathogenesis of Aeromonas hydrophila to goldfish ( Carrassius auratus ), in addition to detect the more sensitive antibiotics for these microbes also, with trials for treatment of the most prevailing bacteria. One hundred apparently infected ornamental fish namely fantail, goldfish ( Carassius auratus auratus) Black molly (Poecillia latipinna) and koi carp ( cyprinus carpio) was randomly collected from private ornamental fish shops. The clinical examinations of these naturally infected fish were recorded. Standard microbiological methods were used for isolation and characterization of bacteria associated with diseased fish. The results revealed that the prevalence of bacterial diseases was 38 % among the examined fish. The isolated and identified bacteria were Aeromonas hydrophila in a percentage of 23.75%, Pseudomonas aeruginosa in a percentage of 22.5% and Enterobacteriaceae in a percentage of 53.75%. Pathogencity of selected bacterial isolate belonged to A. hydrophila was done through experimental challenge via immersion route. Clinical signs and postmortem lesions were recorded; nearly the same clinopathological picture which noticed in naturally infected fish. The therapeutic efficacy of Enrofloxacin (2mg/L with 24 hours between dosing) was evaluated in the treatment of artificial infection with A. hydrophila in goldfish. Mortalities of fish were reduced by administered daily as compared to control group. The isolation frequencies of A. hydrophila in each group during and after medication indicated that Enrofloxacin (Mortril) seemed to give good protection against A. hydrophila in goldfish. Antibiotic sensitivity tests revealed that A . hydrophila were sensitive to sulphatrimethoprim, ciprofloxacin, gentamicine, florfenicol, enrofloxacin and norfloxacin. Pseudomonase sp. were sensitive to oxytetracycline, gentamicine and ciprofloxacin, while Enterobacteriaceae were sensitive to gentamicine and ciprofloxacin.
SOME PROPERTIES OF MORTARS CONTAINING CHROMIUM-STEEL WASTE CHIPS

: Especially in recent times, many studies have been performed on cementitious mortar materials to have different properties. Some of these studies include the production of different building materials to reduce the harmful effects of devices emitting electromagnetic and radioactive waves used at industrial scale. For this purpose, in this work, chromium steel shavings in metallic character obtained during metal machining processes, were used in cementitious mortar mixes by replacing with limestone fine aggregate in a certain ratio. These mixes were tested to examine their physical and mechanical properties. The findings were compared with those of control specimens. With the inclusion of chromium steel chips, bulk density, apparent porosity, water absorption and capillarity of the mortars increased while flexural and compressive strength decreased.
β-blockers augment L-type by targeting spatially restricted β2AR signaling in neurons.

Ca2+ channel activity Abstract G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian cells. Here, we report neuronal excitability of b -blockers carvedilol and alprenolol at clinically relevant nanomolar concentrations. Carvedilol and alprenolol activate b 2 AR, which promote G protein signaling and cAMP/PKA activities without action of G protein receptor kinases (GRKs). The cAMP/PKA activities are restricted within the immediate vicinity of activated b 2 AR, leading to selectively enhance PKA-dependent phosphorylation and stimulation of endogenous L-type calcium channel (LTCC) but not AMPA receptor in rat hippocampal neurons. Moreover, we have engineered a mutant b 2 AR that lacks the catecholamine binding pocket. This mutant is preferentially activated by carvedilol but not the orthosteric agonist isoproterenol. Carvedilol activates the mutant b 2 AR in mouse hippocampal neurons augmenting LTCC activity through cAMP/PKA signaling. Together, our study identifies a mechanism by which b -blocker-dependent activation of GPCRs promotes spatially restricted cAMP/PKA signaling to selectively target membrane downstream effectors such as LTCC in neurons. these data suggest that certain b -blockers selectively promote PKA phosphorylation of b 2 AR in HEK293 and primary hippocampal neurons. The western blot data on PKA phosphorylation of b 2 AR indicates a stimulation of the receptor-medi-ated Gs/AC/cAMP pathway by these b -blockers. We measured ligand-induced Gs a recruitment to b 2 AR with an in situ proximity ligation assay (PLA), which allows direct visualization and quantification of protein-protein interactions. We showed that ISO, CAR and ALP were able to increase the PLA signals between b 2 AR and Gs a , indicating recruitment of Gs a to b 2 AR ( Figure 3A ). As control, TIM had no effect on the recruitment of Gs a to b 2 ARs. The role of Gs/AC in CAR-induced PKA phosphorylation of b 2 AR was further validated by AC-specific inhibition with 2’,5’-dideoxyadenosine (ddA, Figure 3—figure supplement 1 ). These data indicate that CAR and ALP are able to stimulate b 2 AR-Gs signal to increase PKA phosphorylation of the receptor.
Systematic Quantification of Superficial Blood Flow in Near Infrared Spectroscopy Brain Computer Interfaces in a Pediatric Context

Systematic Quantification of Superficial Blood Flow in Near Infrared Spectroscopy Brain Computer Interfaces in a Pediatric Context Andrew Talor Wong Master of Health Science Institute of Biomaterials and Biomedical Engineering University of Toronto 2017 Brain-computer interfaces (BCIs) have been developed as an access pathway for individuals who present as locked-in, but only in adults. Near-infrared spectroscopy (NIRS) signals have been suspected to be influenced by superficial blood flow signals, suggesting that its removal may result in better BCI classification accuracy. Seven typically developing children aged 8-12 participated in three offline sessions in order to assess the suitability of NIRS-BCIs in children, and to examine the effect of superficial blood flow on classification accuracy. Superficial flow was induced using a five-minute bicycle task, and the deep signal was extracted using the multi-distance independent component analysis method. Our results yielded an average classification accuracy of 76.7±8.3% with six participants achieving the 70% threshold for an effective BCI. We demonstrated that the induced superficial flow was able to significantly affect BCI classification accuracy, but removal of the superficial signal offered no or limited benefit in children.
CROSSTALK Comments on CrossTalk 47: Intramuscular lipid accumulation causes/does not cause insulin resistance PKC is not a one-trick pony

This Crosstalk debate (Goodpaster, 2020) firstly highlights the widely reported association between accumulation of intramuscular lipid intermediates, such as diacylglycerols and ceramides, and development of muscle insulin resistance. Secondly, however, it is clear that insulin resistance can arise for different reasons, and under certain conditions, a causative relationship is not supported. It was agreed that further investigation into different mechanisms and their clinical importance is required. In this regard, emphasis is now frequently placed on the importance of defining the species and subcellular localization of diacylglycerols and ceramides thatmodulate insulin action. Although important, on its own this may merely refine the existing correlations to a higher resolution. Demonstration of causation also requires mechanistic interventions downstreamof lipid accumulation. Previous work in muscle and other insulin target tissues has typically concentrated on interference with insulin signal transduction, such as the phosphorylation of IRS-1 or the insulin receptor itself by diacylglycerol-activated protein kinase C (PKC). This focus needs to be broadened: PKC-mediated insulin receptor phosphorylation has been challenged (Brandon et al. 2019) and muscle insulin resistance may in large part be independent of proximal signalling defects (Czech, 2017). Pertinently, while PKCθ activation is frequently linked to muscle insulin resistance, its role extends beyond insulin signalling, encompassing neuromuscular junction remodelling (Lanuza et al. 2014), physical activity and energy expenditure (Gao et al. 2007). In addition, as lipid sensors, PKCs are well-placed to mediate feedback upon lipid metabolism itself, as evidenced by several in vivo studies of PKC-deficient mice exhibiting lipid abnormalities (Schmitz-Peiffer, 2013).
The importance of Winterswijk for understanding placodontiform evolution

: Placodontiformes are basal, semi-aquatic sauropterygians that mostly preyed upon hard-shelled organisms and often had substantial dermal armour. While their fossil remains are rare, they can be found in Triassic sediments throughout Europe, the Middle East and southern China, often in the form of their unusually large, tablet-shaped teeth. Winterswijk, however, boasts one of the most important fossil records for placodontiforms in the world, with two unique genera that are not currently known from anywhere else: Palatodonta bleekeri and Pararcus diepenbroeki. Other than these, more widespread genera are probably also represented in the form of Placodus sp. and Cyamodus sp.
Characterization of the Nonlinear Light Emission by the Liquid Scintillator Used in the Daya Bay Experiment

This thesis has been prepared within the Daya Bay group at the Lawrence Berkeley National Laboratory in California. It describes the measurement of the nonlinearity in light emission by a linear alkylbenze-based liquid scintillator in response to electrons with kinetic energies from ∼0.2 to ∼1.0 MeV. The electrons were generated inside the liquid scintillator volume via Compton scattering of 1.332 MeV gamma rays emitted by a 2.59 MBq 60Co radioactive source. A Compton spectrometer was designed and custom-built to scan over the full range of electron energies. Geant4-based simulations were used to optimize the spectrometer design and estimate systematic effects from energy loss and multiple scattering. The ratio of light emitted relative to the electron’s kinetic energy was found to be (17.59±1.24) % lower at 0.2 MeV compared to 1.0 MeV, demonstrating significant nonlinearity. This precision determination of scintillator nonlinearity will facilitate the improved measurement of reactor antineutrino oscillation by the Daya Bay experiment.
Melting behavior of uranium-americium mixed oxides under different atmospheres

In the context of a comprehensive campaign for the characterisation of minor actinide transmutation fuels, the melting behaviour of mixed uranium-americium dioxides has been experimentally studied for the first time by laser heating, for Am concentrations up to 70 mol % under different types of atmosphere. Extensive post-melting material characterisation were then performed by X-ray absorption spectroscopy and electron microscopy. The melting temperatures observed for the various compositions follow a markedly different trend depending on the experimental atmosphere. Uranium-rich samples melt at temperatures significantly lower (around 2700 K) when they are laser-heated in a strongly oxidising atmosphere (compressed air at 0.3 MPa), compared to the melting points (beyond 3000 K) registered for the same compositions in an inert environment (pressurised Ar). This behaviour has been interpreted on the basis of the strong over-oxidation in air of such samples, leading to lower-melting actual compositions. Thus, the melting temperature trend observed in air is characterised, in the purely pseudo-binary dioxide plane, by an apparent maximum melting temperature around 2850 K for 0.3 < x(AmO 2 ) < 0.5. The melting points measured under inert atmosphere uniformly decrease with increasing americium content, displaying an approximately ideal solution behaviour if a melting point around 2400 K is assumed for pure AmO 2 . In reality, it will be shown that the (U, Am) dioxide system can only be rigorously described in the ternary U-Am-O diagram, due to the aforementioned over-oxidation effect in air and general departures from the oxygen stoichiometry (Oxygen/Metal ratios ≠ 2.0) that have been highlighted by the X-ray Absorption Spectroscopy results. Finally, to better understand the experimental results, thermodynamic computations based on the CALPHAD method will be show.
Assessment of Physicians’ Attitude, Awareness and Knowledge of Evidence Based Medicine: An Observational Study from Yemen

Background: Evidence-based practice is essential for patient safety and high-quality health care. This study aims to assess physicians’ attitude, awareness and knowledge about evidence-based medicine (EBM) and to identify the barriers against its implication in daily medical practice. Method: A questionnaire survey was conducted among physicians working in primary healthcare centers and public hospitals in Mukalla City, Yemen. The main outcome measures were physicians’ attitude, awareness and knowledge score. Results: The response rate was 65.1%. Most of the respondents welcomed the current promotion of EBM (87%). While 14.7% of participants had used EBM resources in their clinical decision and an average of 46.9% of respondents know the EBM baseline methods. The main barrier against evidence based practice was the unavailability of the internet in the work place (57.2%) followed by lack of personal time (53.0%). Factors positively affected physicians’ attitude were older age, longer time since graduation, specialists versus residents, higher qualification and previous EBM training. Awareness and knowledge were affected by EBM training and qualification, respectively. Conclusion: EBM attitude is favorable in the current study but it was not reflected on physicians’ awareness and knowledge. Efforts should be directed toward modifiable factors most probably EBM training with emphasizing on its quality and effectiveness and encouraging higher qualifications. We recommend making EBM electronic resources available in hospitals and health centers. about EBM in the primary care setting concluded that physicians welcomed the promotion of EBM but significant number of barriers and limitations to the implementation of EBM were identified [12]. Other studies also reported positive attitude of physicians toward EBM but lower level of awareness and knowledge [5,9]. The majority of previous work on EBM attitude and knowledge identified barriers against its application in daily practice. Nynke et al. conducted a systematic review on the barriers that residents experience in the application of evidence-based practice, the most frequently mentioned barriers for residents was lack of time [16]. To our knowledge, no similar published studies have been carried out in Yemen or a lower-middle-income country. Therefore, the aims of this study were to determine physicians’ attitudes, awareness and knowledge of EBM and to identify the barrier against evidence-based practice. The results would help to encourage greater use of EBM in patient care.
Social Comparison on Facebook, its Influence on State Self-Esteem and the Role of Public Self-Consciousness

With the pervasive use of Facebook, users are exposed to others’ information and are prone to make social comparison, as per the Social Comparison Theory, influencing their self-evaluation. This study hypothesized that teenagers make more upward social comparison with superior others, than downward, causing them to have lower state self-esteem. This study also posited that high public self-conscious teenagers, who are concerned about their self-portrayal, make more upward comparison, and experience lower state self-esteem. Further, this study posited that the positive association between upward comparison and lower state self-esteem increases by high public self-consciousness. The survey data was gathered from a purposive sample (N = 183) of students from five secondary schools. The results supported all the hypotheses: namely, a negative association between social comparison and state self-esteem; and the moderating role of high public self-consciousness in this association. Findings were discussed, implications, limitations and suggestions for future research stated.
Identification of management zones based on soil and yield in slope citrus field

This paper aims to 1) describe the spatial variation of soil parameters and yield in a steep slope citrus field and 2) identify the management zones based on the variation of soil properties and yield from the point of view of a row-based irrigation system. The test field was located on Iwagi Island, Ehime Prefecture. Soil volumetric water content (VMC) and electrical conductivity (EC) were collected from 51 locations at 3 different depths: the ground surface, 20 cm depth, and 40 cm depth. The yield data of 89 trees between 2010 and 2013 were also collected. Yield, VMC, EC, elevation and combination of yield and soil parameters were classified by cluster analysis with the fuzzy c-means method. The cluster analysis divided, VMC into 3 groups, EC into 3 or 4 groups, yield into 5 groups, elevation into 3 groups and combination of yield and soil parameters into 2 groups. The classified groups clearly showed the influence of cultivation of each variable. Comparing the row irrigation system with the cluster analysis results, row irrigation affected the yield and soil parameters. Some clustered groups in the same irrigation row were also observed. It is suggested that the existing row irrigation system can adjust the variability of the field yield.
Epigenetic Variations Underlying the Pathogenesis of Parkinson’s Disease

Parkinson’s disease is a progressive neurodegenerative disorder which leads to a significant loss in the quality of life. It is due to the death of dopaminergic neurons in the substantia nigra of the mid brain. However, the exact cause for this cell death remains elusive. In the last few years epigenetic mechanisms are gaining increasing importance due to their role in various cellular processes. The cardinal role played by epigenetic mechanisms in the function of the Central Nervous System (CNS) and in the regulation of neurological disorders is one of the most fascinating developments of modern-day neuroscience. Aberrant epigenetic mechanisms are involved in the development of many diseases including neuropsychiatric and neurodegenerative disorders. This manuscript will review the role of epigenetic mechanisms in the pathogenesis of Parkinson’s Disease (PD).
The Information Environment and the Effects of Sentiment on Stock Returns: An International Study

This study investigates sentiment effects on stock returns and the role of information environments in 23 financial markets around the world. Consistent with prior studies, I find that investor sentiment negatively affects subsequent stock returns in global markets. Moreover, sentiment effects on market returns are much weaker in countries with higher information disclosures and better auditing standards, due to higher reliability and transparency of information thus less subjectivity of valuations in these countries. In addition, both the global and local component of investor sentiment has a negative and significant impact on future stock returns. There is also evidence that better information environments reduce the effects of local component of sentiment rather than the global component of investor sentiment. Declaration relating to disposition of project thesis/dissertation I hereby grant to the University of New South Wales or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University libraries in all forms of media, now or here after known, subject to the provisions of the Copyright Act 1968. I retain all property rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation. I also authorise University Microfilms to use the 350 word abstract of my thesis in Dissertation Abstracts International (this is applicable to doctoral theses only). Signature .
LEVELS OF EOSINOPHIL AND MICROPHAGE-SECRETED CYTOKINES IN PLASMODIA- INFECTED CHILDREN IN PORT HARCOURT, NIGERIA

Infection with plasmodia and the attendant complications, including hyper-secretion of pro-inflammatory cytokines, remain a leading cause of high morbidities and mortalities among children in African countries and moreso in Nigeria. This study was aimed at assessing the levels of some eosinophil and macrophage-secreted cytokines (IL-1beta, IL-6, IL-10 and TNF – alpha) in children between 2-12 years of age infected with malaria parasite in Port Harcourt, Nigeria. Blood samples were collected from 352 children (215 test subjects and 137 controls) who were visiting the Hospital, Hospital and and Port Harcourt. Thick blood films were stained with Giemsa method and parasitemia were determined. The cytokines levels were estimated using the ELISA machine (Stat fax-2100) and result reported according to the manufacturers manual. Out of 352 samples that were examined, 215 were infected with various degrees of parasitemia, while the remaining 137 were not infected. There was no case of complication or severe anaemia in malaria as hemoglobin (Hb) of < 5g/dl or packed cell volume (PCV) of < 15% with parasitemia of > 250,000 parasites/ul. On the cytokines, regression analysis demonstrated a negative relationship between parasite density and IL-10 (p=0.09), IL-10 and IL-6 (p= 0.017) while positive relationship were seen between IL-6 parasite density with a p-value of 0.000, TNF-a and parasite density with a p-value of 0.1248, IL-10 and IL-1beta with p-value of 0.4582. The cytokines also showed mean values such as 139.33 ± 7.7, 17.74 ± 1.36, 466.17 ± 21.59 and 66.57 ± 4.03 for IL-10, IL-1beta, IL-6 and TNF-alpha respectively. The raised plasma level of cytokine, IL-10 among the subjects in this investigation could be an advantage as it inhibits the production of pro-inflammatory cytokines that are triggered by malaria parasites or a disadvantage as it down regulates the response of the immune system.
The longitudinal course of interpersonal problems in women in treatment for Binge Eating Disorder

Objective : The goal of this study was to evaluate longitudinal associations of binge eating symptoms with both the severity and style of interpersonal problems in a sample of women ( N =107) receiving a 36-week treatment for Binge Eating Disorder (BED). Method: Severity and style of interpersonal problems, general distress and binge eating symptoms were measured at baseline, 12-week, 24-week and 36-week follow-up. Data were fit to linear and quadratic latent growth models to examine parallel processes between the severity/style of interpersonal problems and binge eating symptoms/general distress. Results: Baseline data indicated heterogeneity in interpersonal styles among patients with BED. The severity of interpersonal symptoms decreased with time linearly, whereas interpersonal style was stable for both dominance and warmth. General distress and binge eating symptoms decreased quadratically over time. Decreases in the severity of interpersonal problems were significantly related to decreases in general distress and marginally significantly related with decreases in binge eating symptoms. Interpersonal styles did not track with changes in general distress or binge eating. Conclusions : The study showed that the severity of interpersonal problems changed over time and in association with the changes in general distress among BED patients in treatment, whereas interpersonal styles were heterogeneous and remained unchanged over time. The results highlight the importance of distinguishing the severity of interpersonal problems from the specific style of interpersonal behavior in considering interpersonal functioning in BED patients. suggesting the independence of many forms of psychopathology from novel useful framework for understanding heterogeneity in BED and other forms for future research and clinical