Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutraceutical management of male infertility-towards new generation therapeutics

Infertility is one of the most significant public health-related concerns globally. Both male and female factors can cause it. Male factors include poor sperm quality, idiopathic oligospermia, asthenozoospermia, and isolated asthenozoospermia. Many substances, collectively known as nutraceuticals, have been studied for their capacity to enhance hormonal state and sperm parameters through different mechanisms. Nutraceuticals are components in dietary supplements prescribed to prevent or treat a wide range of diseases. This article aims to highlight certain nutrients that can help improve male fertility based on recent advancements in the management of male infertility.
Multidisciplinary Approach for the Analysis of Structural Heritage at Risk: The Case Study of Stylite Tower at Umm ar-Rasas (Jordan)

ABSTRACT The results of multidisciplinary research carried out on the Byzantine Stylite Tower in Umm ar-Rasas archaeological site (Jordan) are presented in this paper. The study is grounded on the precarious structural conditions of the tower, assessed by UNESCO since 2008. In 2019, during an archaeological campaign, an aerial photogrammetry survey was performed, allowing for the creation of a detailed 3D model of the tower. This new dataset was compared with existing Geomatics surveys (collected in 2016 with Terrestrial Laser Scanner) within a common reference system, showing that the tower leans dangerously in the northwest direction. With the combined use of the photogrammetric and historical investigations data, the structural vulnerability of the building was analysed in-depth. Starting from the new point cloud dataset, a multi-step geometrical modelling strategy was performed to define the structural model based on the actual geometry of the tower. 3D documentation with aerial photogrammetry made it possible, for the first time, to account for the actual 3D geometry of the upper cell in the structural analysis of the tower. Several possible out-of-plane mechanisms involving the upper cell walls and portions of the tower façades were analysed via kinematic analysis using the floor response spectra. The study revealed a new critical and risky scenario, which suggests a prompt intervention for the safe conservation of the tower.
Community Pharmacist-Led Interventions to Improve Preconception and Pregnancy Health: A Systematic Review

Background: Community pharmacist-led interventions are effective in improving health outcomes; however, their impact in improving preconception and pregnancy health is not clear. This study evaluated the effectiveness of community pharmacist-led interventions which aimed to improve health outcomes of preconception and pregnant women. Methods: A systematic review of the literature, consistent with PRISMA guidelines, was performed. Five electronic databases were searched up to February 2021. Results: Four studies, three in pregnant women and one in preconception women, were identified. The studies focused on improving micronutrient status and smoking cessation. The studies increased knowledge about, and use of, iron supplements, and improved iron status and smoking cessation rates in pregnant women, while improving knowledge regarding, and increasing the use of, preconception folic acid. The studies were ranked as weak to moderate quality. Conclusion: This review provides preliminary evidence for the potential benefit of community pharmacist-led interventions to improve the health of women before and during pregnancy.
Yuxiensis granularis gen. et sp. nov., a Novel Quellkörper-Bearing Fungal Taxon Added to Scortechiniaceae and Inclusion of Parasympodiellaceae in Coronophorales Based on Phylogenetic Evidence

An undetermined saprobic fungal taxon from Yunnan (China) is revealed as a new genus in Scortechiniaceae (Coronophorales). The novel taxon, Yuxiensis, is characterized by immersed to erumpent, semi-globose ascomata, which are not surrounded by any tomentum or conspicuous subiculum, a subcylindrical quellkörper in the centrum, clavate asci with long pedicels and allantoid hyaline ascospores with granular contents. Maximum likelihood and Bayesian posterior probability analyses based on LSU, ITS, tef1 and rpb2 sequence data depict a close phylogenetic relationship of the new genus to Pseudocatenomycopsis, hence, confirming its placement in Scortechiniaceae. Parasympodiellaceae, thus far belonging to Parasympodiellales, is transferred to Coronophorales based on multi-gene phylogenetic evidence. Additionally, the incertae sedis monotypic genus Arthrocristula is treated as a synonym of Parasympodiella, with Arthrocristula hyphenata recombined as Parasympodiella hyphenata comb. nov., as the type strain of Arthrocristula hyphenata clusters inside the Parasympodiellaceae clade along with other Parasympodiella taxa.
Financial behaviors, financial satisfaction, and goal attainment among college-educated young adults: A mediating analysis with latent change scores

Abstract The aim of the study is to investigate how 2,084 U.S. college-educated young adults (61.9% female, and 69.5% non-Hispanic White) navigated the goal attainment process during the transition to adulthood. Using four-wave data collected across eight years, we examined how financial behaviors (self-regulating behaviors) predicted both depressive symptoms (affective goal attainment evaluations) and financial obstacles to goal attainment (cognitive goal attainment evaluations) via financial satisfaction (resources). Given the variability in developmental trajectories (i.e., initial levels and rates of over-time changes) among young adults, we conducted an exploratory mediational analysis with Latent Change Scores. The results revealed indirect-only mediation patterns, and 8 of 16 (50%) indirect effects via financial satisfaction were statistically significant. Collectively, we identified the salient roles of financial behaviors and financial satisfaction among young adults who pursued and attained life goals amid the financial difficulties during the 2007–2009 Great Recession. Our findings should be informative for promoting desired development among the current generation of young adults who were pursuing goals during the financial recession, primarily by indicating the necessity in implementing financial education and providing financial resources for young adults.
Neuroprotective and cerebrovascular effects of endogenous N-Arachidonoyl-GABA and its putative Cox-2 metabolite – GABA conjugate with Prostaglandin E2

Introduction: The aim of the study was to compare the neuroprotective and cerebrovascular effects of bioactive, endogenous lipid – N-arachidonoyl-GABA (AA-GABA) and GABA conjugate with prostaglandin E2 (PGE2-GABA) by evaluation of a morphological state of rat brain tissue and lipofuscin levels under the condition of permanent focal brain ischemia, as well as cerebral circulation under the condition of global transient ischemia. Materials and methods: The study has been implemented using the models of the left middle cerebral artery occlusion (MCAO) and global transient ischemia of the brain. A morphological examination of the brain tissue, a registration of local blood flow by laser flowmeter, and quantitative measurement of lipofuscin by fluorescence spectroscopy were used. Results and discussion: AA-GABA and the putative COX-2 metabolite PGE2-GABA showed significant neuroprotective and cerebrovascular effects in rat models of global and focal cerebral ischemia. In the MCAO model, AA-GABA and PGE2-GABA at a dose of 2 mg/kg/day administered i.p. for 6 or 12 days led to: 1) significant restoration of neurons and glial cells with intracellular regeneration of cytoplasmic and nuclear structures, 2) decrease in brain tissue edema; 3) attenuated thrombosis and stasis, and 4) absence of large necrotic foci in rat brain tissue. AA-GABA and PGE2-GABA at the same dose prevented excessive accumulation of lipofuscin in both brain hemispheres in rats with MCAO. All the studied compounds increase cerebral blood circulation in rats subjected to global transient ischemia. However, the cerebrovascular effect of PGE2-GABA was superior to the activity of AA-GABA and all other tested compounds. AA-GABA and PGE2-GABA, unlike PGE2 and nimodipine, increase the cerebral blood flow in rats with global transient brain ischemia and have no influence on the intact animals. Apparently, the GABAergic vascular system of the brain is involved in the mechanisms of the neuroprotective action of AA-GABA and PGE2-GABA. Conclusion: For the first time, we demonstrated the ability of AA-GABA and its putative metabolite COX-2 PGE2-GABA to improve cerebral circulation, attenuate structural damage and lipofuscin accumulation during cerebral ischemia. The natural origin of AA-GABA, which possesses neuroprotective and cerebrovascular activity, as well as anti-aggregatory activity, allows considering AA-GABA as one of the endogenous protective factors in ischemic brain lesions. Graphical abstract:
Parents’ preferences on the content of a 3D-school group work bullying programme: a needs assessment

ABSTRACT National and international research studies that involve parents for obtaining their insight on content of school bullying prevention programmes are minimal. The purpose of this research study was to conduct a needs assessment to obtain parents’ preferences in terms of the content that are to be included or addressed in a potential three dimensional-bullying programme (3D-bullying programme) for parents, educators, and learners in a South African context. This research study used a self-developed questionnaire and a cross-sectional survey at five schools in South Africa (SA) with varying socio-economic circumstances. The research methodology followed a quantitative research approach and a quantitative-descriptive survey design. The findings could be useful for developing a three-dimensional social group work school bullying programme to address bullying in primary schools.
Five-Year Analysis of Air Pollution in Istanbul Including Also the Impact of the COVID-19 Pandemic

INTRODUCTION: Particulate matter, sulfur dioxide, ozone, and nitrogen oxide compounds are the main air pollutants. The purpose of this research is to analyze the five-year air quality of Istanbul and examine the effect of movement restrictions due to the COVID-19 pandemic on pollutants. METHODS: The public data of the National Air Quality Observation Network has been utilized. The research has been conducted based on the five-year daily averages of PM10, NO2, and NOx pollutants for Istanbul between 2016 - 2020. The data of stations which measured for 75% and more throughout the year has been used. The effect of lockdowns enforced due to COVID-19 was revealed by comparing data of pollutants from April and May of 2020 to the same period in 2019. RESULTS: There were 12 stations between 2016 – 2018, and 39 stations in 2019 and 2020 which measured particulate matter and nitrogen oxide compounds. Only 9 stations reached the standard of measuring pollution for 75% and more throughout the year. The PM10, NO2, and NOx levels measured by all the 9 stations between 2016 - 2020 are above the limit values set by the World Health Organization (WHO). The lockdowns in 2020 have not been helping improvements in air pollution issue. However, there have been regressions of 33.4%, 59.6%, and 52.6% in the overall average particulate matter, nitrogen oxide, and nitrogen dioxide concentrations during the lockdowns between 23-26 of April, 1-3 of May, and 23-26 of May, respectively. DISCUSSION AND CONCLUSION: The air pollution issue in Istanbul has not improved in a meaningful and significant manner for the last five years. There is a significant deficiency in measuring traffic pollution. It has been found that two days long lockdowns and physical movement restrictions due to COVID-19 have significantly contributed to a significant regression in the overall concentration of air pollutants.
Leveraging AI to Estimate Caribou Lichen in UAV Orthomosaics from Ground Photo Datasets

Relating ground photographs to UAV orthomosaics is a key linkage required for accurate multi-scaled lichen mapping. Conventional methods of multi-scaled lichen mapping, such as random forest models and convolutional neural networks, heavily rely on pixel DN values for classification. However, the limited spectral range of ground photos requires additional characteristics to differentiate lichen from spectrally similar objects, such as bright logs. By applying a neural network to tiles of a UAV orthomosaics, additional characteristics, such as surface texture and spatial patterns, can be used for inferences. Our methodology used a neural network (UAV LiCNN) trained on ground photo mosaics to predict lichen in UAV orthomosaic tiles. The UAV LiCNN achieved mean user and producer accuracies of 85.84% and 92.93%, respectively, in the high lichen class across eight different orthomosaics. We compared the known lichen percentages found in 77 vegetation microplots with the predicted lichen percentage calculated from the UAV LiCNN, resulting in a R2 relationship of 0.6910. This research shows that AI models trained on ground photographs effectively classify lichen in UAV orthomosaics. Limiting factors include the misclassification of spectrally similar objects to lichen in the RGB bands and dark shadows cast by vegetation.
MPeat—A fully coupled mechanical‐ecohydrological model of peatland development

Mathematical models of long‐term peatland development have been produced to analyse peatland behaviour. However, existing models ignore the mechanical processes that have the potential to provide important feedback. Here, we propose a one‐dimensional model, MPeat, that couples mechanical, ecological and hydrological processes via poroelasticity theory, which couples fluid flow and solid deformation. Poroelasticity formulation in the MPeat is divided into two categories, fully saturated and unsaturated. To validate this formulation, we compare numerical solutions of the fully saturated case with analytical solutions of Terzaghi's problem. Two groups of MPeat simulations are run over 6,000 years using constant and variable climate, and the results are compared to those of two other peat growth models, DigiBog and the Holocene Peat Model. Under both climatic conditions, MPeat generates the expected changes in bulk density, active porosity and hydraulic conductivity at the transition from the unsaturated to the saturated zone. The range of values of peat physical properties simulated by MPeat shows good agreement with field measurement, indicating plausible outputs of the proposed model. Compared to the other peat growth models, the results generated by MPeat illustrate the importance of poroelasticity to the behaviour of peatland. In particular, the inclusion of poroelasticity produces shallower water table depth, accumulates greater quantities of carbon and buffers the effect of climate changes on water table depth and carbon accumulation rates. These results illustrate the importance of mechanical feedbacks on peatland ecohydrology and carbon stock resilience.
Analysis of Methods for CubeSat Mission Design Based on in-orbit Results of KRAKsat Mission

The success rate of currently performed CubeSat missions shows that despite their popularity, small satellites are still not as reliable as larger platforms. This research was conducted to analyse in-orbit experience from the KRAKsat mission and discuss methods for mission design and engineering that can increase CubeSats reliability and prevent their failures. The main purpose was to define best practices and rules that should be followed during mission development and operations to ensure its success based on the overview of the lessons learned from KRAKsat and problems encountered during its mission. This paper summarizes the experiences obtained and provides methods that can be used while carrying out future robust CubeSat projects. It was written to prove that there are some parts of the small satellite missions that are often neglected in the university-led projects and, by ensuring proper testing and planning before the actual mission, its reliability can increase. The following analysis could be used as a guide during the development of the next CubeSat projects.
Anticancer Potential of Lipophilic Constituents of Eleven Shellfish Species Commonly Consumed in Korea

The present study was aimed to investigate the composition and contents and the major lipophilic compounds, including the sterols, fatty acids, and tocols of shellfish species. Moreover, to explore the antitumor activity of these lipophilic constituents, their cytotoxicity potentials were determined against five different human cancer cells, including colon carcinoma (HCT116), epithelial melanoma (A2058), glioblastoma multiforme (T98G), lung carcinoma (A549), and adenocarcinoma (HeLa). The results show a significant variation in the contents and composition of lipophilic constituents among the studied species. The highest omega-3 (n-3) polyunsaturated fatty acids (PUFAs) were recorded from arrow squid and pacific oysters, accounting for 53.2% and 53.0% of their total fatty acids, respectively. However, the highest cholesterol content was also recorded in arrow squid (154.4 mg/100 g; 92.6% of total sterols). In contrast, in the Japanese littleneck, Yesso scallop, and common orient clam, cholesterol was just 17.1%, 18.3%, and 18.9% of total sterols, respectively, making them the richest source of non-cholesterol sterols (NCS). Lipids extracted from shellfish species showed ABTS+•- and DPPH•-scavenging activities. In the cytotoxicity analysis, lipids extracted from the Argentine red shrimp showed the highest cytotoxicity against glioblastoma multiforme T98G cells, with an IC50 value of 12.3 µg/mL. The composition and cytotoxicity data reported herein may help explore the nutritional and anticancer potentials of shellfish species.
PENGARUH UKURAN PERUSAHAAN, PROFITABILITAS, SOLVABILITAS, KUALITAS AUDIT, OPINI AUDIT, KOMITE AUDIT TERHADAP AUDIT REPORT LAG

Keterlambatan laporan audit adalah rentang waktu yang diperlukan untuk menyelesaikan audit yang dilakukan oleh auditor yang diukur dari selisih waktu antara tanggal laporan keuangan dan tanggal opini audit dalam laporan keuangan. Lamanya waktu yang dibutuhkan auditor untuk mengaudit laporan keuangan perusahaan dapat berdampak pada pengambilan keputusan oleh berbagai pihak. Oleh karena itu, laporan keuangan harus disajikan secara akurat dan tepat waktu agar lebih bermanfaat bagi yang membutuhkan informasi. Tujuan penelitian ini adalah untuk mengetahui pengaruh ukuran perusahaan, solvabilitas, profitabilitas, kualitas audit, opini audit dan komite audit terhadap audit report lag. Penelitian ini dilakukan pada perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia tahun 2016-2018. Jenis data yang digunakan adalah data kuantitatif berupa laporan keuangan auditan beserta catatan atas laporan keuangan dan data kualitatif berupa data perusahaan pertambangan. Sampel yang digunakan adalah 41 perusahaan dengan jumlah observasi 123, dengan metode purposive sampling. Teknik analisis yang digunakan adalah analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa ukuran perusahaan berpengaruh positif terhadap audit report lag. Solvabilitas dan kualitas audit berpengaruh negatif terhadap keterlambatan laporan audit. Profitabilitas, opini audit, dan komite audit tidak berpengaruh terhadap keterlambatan laporan audit. Penelitian selanjutnya dapat mengembangkan penelitian ini dengan menggunakan variabel lain yang secara teoritis berpengaruh terhadap audit report lag, seperti perubahan auditor dan dewan komisaris.
REPRODUCTIVE PERFORMANCE OF EGYPTIAN BUFFALO BULLS ADMINISTRATED WITH N-ACETYLCYSTEINE, L-CARNITINE, OR THEIR COMBINATION

SUMMERY his study was to evaluate the effect of daily oral administration of N-acetylcysteine (NAC), L-carnitine (L-C), or their Combination for 2 months pre-semen collection on semen quality, sexual desire and some blood parameters traits of Egyptian buffalo bulls. A total of 20 bulls (400±37 kg LBW and 24-25 mo old) were divide into 4 groups. In group1 (G1, control), G2, G3 and G4, animals fed a basal ration and the managed under the same conditions, and were received orally a daily dose of 0, 3 L-C, 3 g NAC, or 1.5 g NAC +1.5 g L-C as a combination/bull/day, respectively, for 2 months. The results showed that bulls that received the combination dose (G4) increased (P<0.05) the concentration of total proteins, albumin, globulin and glucose, while it decreased (P<0.05) total cholesterol, triglyceride, creatinene concentrations, and AST and ALT activities compared with the control and other groups. All physical characteristics in fresh and thawed semen were higher (P<0.05) in all treated groups than in the control group, being the best in G4. Plasma testosterone and total antioxidant capacity concentrations were increased (P<0.05) in G4, G3 and G2 compare with the control (G1), being the best for G4 bulls. In conclusion, an oral dose of 1.5 g NAC plus 1.5 g L-C bull/day, as a combination, for 2 months pre-semen collection improves health status, immunity response and antioxidant capacity of buffalo bulls to produce semen with high quality require for spreading the tool of artificial insemination in buffaloes. combination some biochemicals, enzyme activity, testosterone profile and total antioxidant capacity in blood plasma of buffalo bulls.
Automatic Segmentation and Classification Methods Using Optical Coherence Tomography Angiography (OCTA): A Review and Handbook

Optical coherence tomography angiography (OCTA) is a promising technology for the non-invasive imaging of vasculature. Many studies in literature present automated algorithms to quantify OCTA images, but there is a lack of a review on the most common methods and their comparison considering multiple clinical applications (e.g., ophthalmology and dermatology). Here, we aim to provide readers with a useful review and handbook for automatic segmentation and classification methods using OCTA images, presenting a comparison of techniques found in the literature based on the adopted segmentation or classification method and on the clinical application. Another goal of this study is to provide insight into the direction of research in automated OCTA image analysis, especially in the current era of deep learning.
Health Behavior, Emotional Intelligence, and Stress of Elementary School Students in Korea

Background: We aimed to provide the baseline data of nursing intervention for promoting the health promotion and promotion of growth and development for elementary students. Methods: By subjecting the 887 elementary students from 20 elementary schools located in the northern area of Gyeonggi-do Province, South Korea, data were gathered from April 10–May 30, 2017. The SPSS was used for analysis of data. Results: Some elements of emotional intelligence were found to differ depending on the gender and family type of lower-grade children, and depending on gender, sleep time, family type, and physical activity experience of higher-grade children. Some factors of stress were found to have differences according to sleeping time of the lower grades, and according to gender, sleeping time, family type, and whether they have experience in physical activity of higher-graders. Conclusion: It is possible to improve emotional intelligence and solve the stress of elementary students. This study will be the baseline data on developing the Health Promotion Education Arbitration Program for elementary students.