Miracle-dz/UniFAR-FTUs huggingface dataset:
A Mixed Methods Investigation of Stress and Wellbeing Factors Contributing to Burnout and Job Satisfaction in a Specialist Small Animal Hospital

Occupational burnout is a critical issue affecting the welfare of veterinary care providers, their patients, and the sustainability of veterinary healthcare organizations. The current research aimed to evaluate the prevalence of and factors contributing to stress, wellbeing, burnout symptoms and job satisfaction among clinical and non-clinical staff at a large specialist small animal hospital in Australia. Participants completed an anonymous online survey including self-report measures of job satisfaction and symptoms of burnout, and open-text response questions probing sources of stress and wellbeing. Subsequently, participants rated how frequently they experienced commonly reported sources of veterinary stress, and a series of focus groups were conducted with clinical and non-clinical teams. The survey was completed by 249 participants (overall response rate = 70%; 67.1% “clinical;” 17.3% “non-clinical;” 5.6% “other”). Five focus groups (including 38 of the survey participants) were subsequently conducted with groups of clinical and non-clinical staff. The majority of respondents (80.7%) reported being satisfied, very satisfied, or extremely satisfied with their job. At the same time, 57.7% of respondents exceeded the threshold for burnout on at least one burnout dimension, with 48.1% reporting high levels of emotional exhaustion, 30.2% reported high levels of cynicism, and 16.3% reporting low levels of professional efficacy. Open text responses and focus group transcripts revealed three common sources of stress and wellbeing. Stressors included communication (conflict within teams), clients (dealing with client emotions and expectations), and heavy caseload. Wellbeing was enhanced by people (team cohesion, respect for colleagues), practice (variety, autonomy, challenge), and purpose (meaningful work and impact). Overall, for both clinical and non-clinical survey respondents, “heavy workload” was rated as the most frequent source of stress. Despite high levels of job satisfaction, approximately two thirds of respondents reported at least one symptom of burnout. Convergent results from the survey and focus groups indicated that strong relationships with colleagues and the intrinsic meaningfulness of the work were key sources of wellbeing and job satisfaction. On the other hand, challenging workplace interactions with colleagues and clients, as well as heavy workload, were identified as key stressors contributing to burnout symptoms.
Determinants of tourists’ intention to share travel experience on social media: an fsQCA application

ABSTRACT Sharing travel experience on social media has gained substantial popularity in the Internet era. However, existing knowledge about tourists’ determinants for sharing remains inconsistent and scattered. This study seeks to propose an innovative direction to analyze the determinants of tourists’ intention to share travel experience on social media. Building upon the complexity theory, this study implemented an asymmetrical analysis by applying the fuzzy-set qualitative comparative analysis (fsQCA) approach on a sample of 383 valid questionnaires. A structural equation modeling analysis and cross-tabulation analysis were also performed. The results revealed five causal configurations of determinants that lead to Chinese tourists’ high sharing intention on WeChat. The finding fills the gap in research on determinants to share travel experiences on strong-tie social media platforms and offers practical insights and marketing advice about how to encourage tourists to share their travel experiences on mainstream social media.
The Effect of Nostalgic Contents on Self-Esteem: The Mediating Role of Loneliness

Background Research has demonstrated that nostalgia can improve self-esteem as a positive psychological resource in Western culture. Moreover, nostalgia is cross-culturally consistent. Therefore, nostalgia triggered by an event reflection task affects self-esteem in Eastern cultures. However, it is unknown whether the collective or personal content of nostalgia affects self-esteem and the role of loneliness in this process. Purpose This study examined the cross-cultural consistency of nostalgia’s impact on self-esteem, whether nostalgic content affects self-esteem levels, and what role loneliness plays in this process. Methods We conducted two experiments in this study. Experiment 1 used an event reflection task with different instructions to prime the nostalgia and control groups. Participants were asked to complete the Positive and Negative Affect Scale and a revised positive version of the Rosenberg Self-Esteem Scale after priming. Experiment 2 used different instructions and pictures to prime the social and personal nostalgia groups. The PANAS, a revised positive version of the Rosenberg Self-Esteem Scale, and the Russell Loneliness Scale were then administered to the groups. Results Experiment 1 showed that in the nostalgic condition, self-esteem was higher than in the control condition. In the nostalgia condition, participants felt more positive than in the control condition. Experiment 2 revealed that self-esteem was higher in the collective nostalgic context than in the personal nostalgic context. Regarding the positive effect, participants felt more positive in the collective nostalgic context than in the personal nostalgic context. Loneliness also had a mediating effect on this process. Conclusion Results show that nostalgia affects self-esteem through cross-cultural consistency and social nostalgia can be a resource for positive mental health. Moreover, loneliness plays a significant role in mediating nostalgia’s effect on self-esteem.
The Busan Regional CardioCerebroVascular Center Project’s Experience Over a Decade in the Treatment of ST-segment Elevation Myocardial Infarction

Objectives The Regional CardioCerebroVascular Center (RCCVC) project was initiated to improve clinical outcomes for patients with acute myocardial infarction or stroke in non-capital areas of Korea. The purpose of this study was to evaluate the outcomes and issues identified by the Busan RCCVC project in the treatment of ST-segment elevation myocardial infarction (STEMI). Methods Among the patients who were registered in the Korean Registry of Acute Myocardial Infarction for the RCCVC project between 2007 and 2019, those who underwent percutaneous coronary intervention (PCI) for STEMI at the Busan RCCVC were selected, and their medical data were compared with a historical cohort. Results In total, 1161 patients were selected for the analysis. Ten years after the implementation of the Busan RCCVC project, the median door-to-balloon time was reduced from 86 (interquartile range [IQR], 64–116) to 54 (IQR, 44–61) minutes, and the median symptom-to-balloon time was reduced from 256 (IQR, 180–407) to 189 (IQR, 118–305) minutes (p<0.001). Inversely, the false-positive PCI team activation rate increased from 0.6% to 21.4% (p<0.001). However, the 1-year cardiovascular death and major adverse cardiac event rates did not change. Even after 10 years, approximately 75% of the patients had a symptom-to-balloon time over 120 minutes, and approximately 50% of the patients underwent inter-hospital transfer for primary PCI. Conclusions A decade after the implementation of the Busan RCCVC project, although time parameters for early reperfusion therapy for STEMI improved, at the cost of an increased false-positive PCI team activation rate, survival outcomes were unchanged.
Sources and pathways of intraseasonal meridional kinetic energy in the equatorial Atlantic Ocean

In the equatorial Atlantic Ocean, meridional velocity variability exhibits a pronounced peak on intraseasonal timescales whereas zonal velocity dominantly varies on seasonal to interannual timescales. We focus on the intraseasonal meridional velocity variability away from the near-surface layer, its source regions and its pathways into the deep ocean. This deep intraseasonal velocity variability plays a key role in equatorial dynamics as it is an important energy source for the deep equatorial circulation. The results are based on the output of a high-resolution ocean model revealing intraseasonal energy levels along the equator at all depths that are in good agreement with shipboard and moored velocity data. Spectral analyses reveal a pronounced signal of intraseasonal Yanai waves with westward phase velocities and zonal wavelengths longer than 450 km. Different sources and characteristics of these Yanai waves are identified: near the surface between 40°W and 10°W low-baroclinic-mode Yanai waves with periods of around 30 days are exited. These waves have a strong seasonal cycle with a maximum in August. High-frequency Yanai waves (10–20-day period) are excited at the surface east of 10°W. In the region between the North Brazil Current and the Equatorial Undercurrent high-baroclinic-mode Yanai waves with periods between 30 and 40 days are generated. Yanai waves with longer periods (40-80 days) are shed from the Deep Western Boundary Current. The Yanai wave energy is carried along beams east- and downward thus explaining differences in strength, structure and periodicity of the meridional intraseasonal variability in the equatorial Atlantic Ocean.
Is it time to retire sentinel lymph node biopsy and use multi-omics prediction models?

© Annals of Translational Medicine. All rights reserved. Ann Transl Med 2022;10(12):655 | https://dx.doi. org/10.21037/atm-2022-21 The approach to the axillary lymph nodes (ALN) in breast cancer surgery has shifted from the ALN dissection (ALND) in all patients to intraoperative sentinel lymph node biopsies (SLNB) and full dissection is rarely considered. Whilst the more conservative approach causes less morbidity in comparison to ALND, the incidence of complications is still significant, including pain, sensory or motor disorders and lymphoedema, affecting upper limb function in up to 22% of patients (1). This is particularly relevant to patients with small tumours and a lower risk of metastasis to ALN, such as a subset of the triple-negative breast cancer (TNBC). Models for lymph node metastasis (LNM) prediction tool are reported amongst breast cancer, but majority are non-specific to TNBC and do not include genomic variables (2-7). Therefore, predictors of LNM are required but models with sufficient predictive value are still lacking for TNBC. The study by Li et al. (8) worked on samples from a pre-established cohort of 445 patients with TNBC who underwent surgery at the Fudan University Shanghai Cancer Center. The primary aim of the study was to employ a multi-omics approach to determine any predictors of LNM in TNBC; 38.0% of the cohort had LNM, genomics data was available via WES in 59.6% and via OncoScan in 86.5%; and transcriptomics data available was available in 77.8% via RNA-seq. Following the collection of this data, the group was divided into a training set used to develop the model (n=305) and a validation set (n=140). The division was based on whether patients had surgery before an arbitrary date and the two sets had no significant differences in their baseline characteristics. Models based on key markers of five different approaches [clinical, genomics, somatic copy number alterations (SCNA), transcriptomics and molecular subtypes] were then constructed with the aim of achieving good predictive value in the validation set. The results from these were then used to construct a multi-omics model consisting of five markers (tumour size, SCNAs of ZBTB6 and MTHFD1, mRNA levels of GLP1R and NPY5R). The molecules selected as yet have not been mechanistically linked to lymph node spread. Distinctive signatures were observed between lymph node positive and negative cases. SCNA analysis revealed that deletion and amplification were less commonly seen in samples with LNM but had poor predictive value in the validation set. The analysis of the mutational profiles found statistically significant differences in the frequency of mutations in various genes (WDR63, COL5A1, ATG2B, C17orf104, DDX41, F5 and LOXHD1) but the mutational profile was not predictive of LNM status. These genes may be of passenger status. Interestingly, LNM-positive samples had a slightly higher mutational burden but this was not statistically significant, Editorial
Non-Magnetic Intermediate-Temperature Stars: A Review

The literature concerning spectroscopic studies, abundances, photometry, and systematics of intermediate-temperature (9500 K < Teff < 16000 K) normal, Hg-Mn, and related stars is reviewed. The review is restricted mainly to papers published since the last international meeting on chemically peculiar stars at Liege in June 1981, and is intended to be complete to 31 December 1984.
Perimortem and postmortem caesarean section: a systematic review

Rationale: Perimortem caesarean section (PMCS) is an emergency procedure performed in pregnant women over 20 weeks of gestation with cardiac arrest, in order to save the mother and the foetus, or only one of them. The objective of the review was to present clinical traits and evaluate survival of mothers and newborns as well as the complications following PMCS. Materials and methods: A systematic review between March and May 2021 was performed using the PRISMA method with the terms "perimortem caesarean section" "postmortem caesarean section", "maternal cardiac arrest", "perimortem caesarean section "AND "case report" "postmortem caesarean section" AND "case report". Results: 23 papers from 12 countries with 39 cases were counted. Of the total sample, 17.94% of the mothers survived and of these, 42.85% had neurological complications. Of 39 newborns counted, 69.23% survived, 28.20% died and in 2.56% the information was missing. 30.76% of the cases followed the five-minute rule and 56.41% required 6 or more minutes, 12.82% did not specify time. Conclusion: The results of this analysis demonstrated higher mortality in women who had a cardiac arrest during pregnancy related to the neonates who survived. The possibility of performing PMCS should neither be ruled out even if the established five-minute time frame has passed, nor should time be invested in verifying foetal viability.
Moderate Dose Irradiation Induces DNA Damage and Impairments of Barrier and Host Defense in Nasal Epithelial Cells in vitro

Purpose Radiotherapy (RT) is the mainstay treatment for head and neck cancers. However, chronic and recurrent upper respiratory tract infections and inflammation have been commonly reported in patients post-RT. The underlying mechanisms remain poorly understood. Method and Materials We used a well-established model of human nasal epithelial cells (hNECs) that forms a pseudostratified layer in the air-liquid interface (ALI) and exposed it to single or repeated moderate dose γ-irradiation (1Gy). We assessed the DNA damage and evaluated the biological properties of hNECs at different time points post-RT. Further, we explored the host immunity alterations in irradiated hNECs with polyinosinic-polycytidylic acid sodium salt (poly [I:C]) and lipopolysaccharides (LPS). Results IR induced DNA double strand breaks (DSBs) and triggered DNA damage response in hNECs. Repeated IR significantly reduced basal cell proliferation with low expression of p63/KRT5 and Ki67, induced cilia loss and inhibited mucus secretion. In addition, IR decreased ZO-1 expression and caused a significant decline in the transepithelial electrical resistance (TEER). Moreover, hyperreactive response against pathogen invasion and disrupted epithelial host defense can be observed in hNECs exposed to repeated IR. Conclusion Our study suggests that IR induced prolonged structural and functional impairments of hNECs may contribute to patients post-RT with increased risk of developing chronic and recurrent upper respiratory tract infection and inflammation.
SHEAR BOND STRENGTH OF TWO PORCELAIN REPAIRING SYSTEMS USING DIFFERENT SURFACE PREPARATION TECHNIQUES

Statement of the problem: Fracture or chipping of veneering porcelain in PFM restorations is considered to be a very common failure in clinical practice. Many clinicians are using different intra- oral surface preparation techniques and repairing systems. However, the success rate is still of concern to be verified as an acceptable treatment modality. Materials and methods: A total of 40 circular porcelain fused to metal specimens with 1 cm in diameter and 4 mm thickness were fabricated using feldspathic porcelain (VITA VMK Master, VITA, Germany) and nickel chromium base metal alloy (Wiron Light, BEGO, Germany). All 40 samples were subjected to 3000 cycles of thermo-cycling before the repair was performed. The specimens were divided into two equal groups of 20 samples each according to the repairing system used. (V; one step self-adhesive flowable composite resin, Vertise Flow, Kerr) and (F; two steps, Embrace First Coat, Pulpdent) followed by the application of self-adhesive composite resin (Vertise Flow). Each group of the two main groups was divided into two equal subgroups of 10 samples each according to the surface treatment applied before repair. (D; diamond stone surface roughening) and (H; hydrofluoric acid etching). Half of the specimens were subjected to accelerated photo-thermal aging before testing the shear bond strength. Shear bond strength was determined using NEXYGEN from Lloyd Instruments at a crosshead speed of 0.5mm/min. Statistical analysis was carried out using Kolmogorov-Smirnov and Shapiro-Wilk tests. Results: No statistically significant differences were found between the two repairing systems or between the two surface treatments either before or after accelerated photo-thermal aging. The only significant difference was recorded between the two subdivisions where the two steps system was used on etched surfaces before and after photo-thermal aging. Conclusion: The one step direct application of the self adhesive flowable composite resin (Vertise Flow) can be used without the incorporation of the additional primer (Embrace First Coat) step as they showed comparable results. Diamond stone roughening can be a good alternative to hydrofluoric acid. Clinical recommendations: The one step direct application of the self adhesive flowable composite resin (Vertise Flow) can be used effectively without the incorporation of the additional primer (Embrace First coat) step. When attempting to use the two steps system of First Coat plus Vertise Flow, it should not be used with hydrofluoric acid etching.
Family Alliance and Intergenerational Transmission of Coparenting in Gay and Heterosexual Single-Father Families through Surrogacy: Associations with Child Attachment Security

Parents tend to internalize the coparenting model they experienced during childhood and enact it in their coparenting relationships as adults. These interactive patterns may, in turn, shape their children’s internal working models of attachment relationships. The present study recruited 31 gay and 28 heterosexual single-father families through surrogacy to examine family alliance quality and the mediating role of observed supportive and conflictual coparenting in the association between the coparenting quality single fathers experienced in their families of origin and the attachment security of their children. All single fathers lived in Italy, were cisgender and White, and had a child aged 6–12 years (M = 97.73 months; SD = 20.48; 47.5% girls) who they coparented with nonparental caregivers (i.e., 33 grandparents, 18 babysitters, 8 uncles/aunts). Families did not differ in family alliance dimensions based on fathers’ sexual orientation. Additionally, single fathers who experienced greater coparenting quality in their families of origin demonstrated lower levels of conflictual coparenting, which, in turn, were associated with greater child attachment security. In contrast, observed supportive coparenting did not mediate this relation. The results emphasize the need to reconceptualize the dyadic coparental unit in single-father surrogacy families to include extended family members and nonrelatives.
Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes

Introduction Traumatic spinal cord injury (TSCI) is a life-threatening neurological disorder and there is a lack of biomarker research, particularly human studies that could help to categorize the severity and predict the outcome. We aimed to assess the role of serum Ubiquitin C-terminal hydrolase L1 (UCH-L1) and Neuroglobin (NGB) in predicting severity and outcome of TSCI. Methods This prospective study included 63 participants categorized into 33 patients with various types of TSCI and 30 unrelated healthy volunteers. Neurosurgical [American spinal injury association (ASIA) impairment score (AIS)] and radiological [using spine computed tomography (CT) and magnetic resonance imaging (MRI)] assessments were performed on the included patients to determine the severity and the level of injury with neurological follow-up of patients within 6 months post-injury. Serum UCH-L1 and NGB were measured for all participants using commercially available ELISA assay kits. Results Of the included patients, 20 (60.60%) had partial SCI and the remaining 13 patients (39.39%) had complete SCI. On follow-up, 19 patients (57.57%) showed improved AIS, while 14 cases (42.42%) did not show any improvement in their AIS scores. There was significantly higher median serum UCHL1 value among cases compared to controls (1723 pg/mL and 657 pg/mL, respectively), p ˂ 0.05. There was an insignificant rise of serum NGB levels among cases in comparison with the controls (15.2pg/mL and 7.52pg/mL, respectively, p ˃ 0.05). Significantly lower initial median serum UCHL1 levels (pg/mL) were observed in patients with improved AIS during the neurological follow-up compared with those who did not show any improvement in their AIS score (1723, and 4700 respectively, p ˂ 0.05), with lack of significant difference in the initial median serum NGB levels, p ˃ 0.05. Conclusion Initial serum UCHL1 assay could be a helpful marker in reflecting the degree of TSCI and predicting its outcome, though NGB needs further assessment.
Instagram Photo Sharing and Its Relationships With Social Connectedness, Loneliness, and Well-Being

Photo sharing is one of the most popular online social media activities and has been associated with changes in mental health. Research investigating the effect of sharing photos on a social media user’s social connectedness, loneliness, and well-being has generated conflicting results. This study analyzed the effect of Instagram photo sharing on the relationships among social connectedness, loneliness, and well-being. The study focused on photos sharing separate to viewing photos to understand the specific effect of photo sharing. The research measured how those with transient and chronic levels of loneliness respond differently to photo sharing, which has not been previously considered. Well-being and loneliness are conceptualized as dependent variables that have a relationship with social connectedness as an independent variable, which is moderated by the number of photos shared. Results from an online survey of 373 participants found Instagram photo sharing does significantly moderate relationships among social connectedness, loneliness, and well-being. Highest levels of photo sharing were found to have the largest moderating effect. Levels of well-being decreased as social connectedness and photo sharing increased. Differences were found for types of loneliness where photo sharing was most beneficial at low levels of social connectedness for transient loneliness. In contrast, for those experiencing chronic trait loneliness, high levels of photo sharing were associated with highest levels of loneliness when social connectedness was high. One obvious implication for social media and policy may lie in education for users and technology enhancement for optimal photo sharing levels that minimize loneliness and maximize well-being.