Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual Desire, mood disorders and sleep disturbances in female BMS patients: a controlled study.

BACKGROUND Burning mouth syndrome is a chronic orofacial pain with intraoral burning and other oral dysaesthetic symptoms that significantly affects the quality of life. The aim of this study is to evaluate the sexual desire in women with BMS and to investigate the possible related factors. METHODS A case-control study was performed. BMS patients were enrolled according to the International Classification of OroFacial Pain criteria. Demographic variables were collected. We evaluated pain with Numeric Rating Scale (NRS), Visual Analogue Scale (VAS) and Total Pain Rating Index (T-PRI), anxiety and depression using the Hospital Anxiety and Depression Scale (HADS-A e HADS-D), sleep disturbances with Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), and sexual desire using Sexual Desire Inventory (SDI). RESULTS A total of 50 BMS women and 50 healthy controls were enrolled. Compared with the controls, the BMS patients showed higher scores in the NRS (7,81±1,71 vs 0,14±0.40; p <0.0001), TPR-I (10,50±4,86 vs 0,36±1,06; p <0.0001), HADS-A (11,86±2,85 vs 3,90±2,81; p <0.0001), HADS-D (8,04±3,18 vs 1,42±1,86; p <0.0001) and PSQI (9,04±2,62 vs 4,64±3,27; p <0.0001). The mean SDI in the study group was significantly lower compared to healthy controls (32,36±14,45 vs 69,70±19,94; p <0.0001). No correlation was found between SDI and others items explored. CONCLUSION In line with previous studies, anxiety, depression and sleep disturbances are more common in BMS patients than in healthy population. This pilot study demonstrates for the first time an association between BMS and low sexual desire.
Should Steering Settings be Changed by the Driver or by the Vehicle Itself?

Introduction Cars are increasingly computerized, and vehicle settings such as steering gain (SG) can now be altered during driving. However, it is unknown whether transitions in SG should be adaptable (i.e., triggered by driver input) or adaptive (i.e., triggered automatically). We examined this question for road segments expected to require different SG. Objective This paper aimed to investigate whether SG mode changes should be made by the driver or automatically. Methods Twenty-four participants drove under four conditions in a simulator: fixed low gain (FL), fixed high gain (FH), a machine-initiated steering system, which switched between the two SG levels at predetermined locations (MI), and a driver-initiated steering system, in which the SG level could be changed by pressing a button on the steering wheel (DI). Results Participants showed poorer lane-keeping and reported higher effort for FH compared to FL on straights, while the opposite held true on curved roads. On curved roads, the MI condition yielded better lane-keeping and lower subjective effort than the DI condition. However, a substantial portion of the drivers gave low preference rankings to the MI system. Conclusion Drivers prefer and benefit from a steering system with a variable rather than fixed gain. Furthermore, although automatic SG transitions reduce effort, some drivers reject this concept. Application As the state of technology advances, MI transitions are becoming increasingly feasible, but whether drivers would want to delegate their decision-making authority to a machine remains a moot point.
Circulating Myeloid Cell-derived Extracellular Vesicles as Mediators of Indirect Acute Lung Injury.

Blood-borne myeloid cells, neutrophils and monocytes, play a central role in the development of indirect acute lung injury (ALI) during sepsis and non-infectious systemic inflammatory response syndrome (SIRS). By contrast, the contribution of circulating myeloid cell-derived extracellular vesicles (EVs) to ALI is unknown, despite acute increases in their numbers during sepsis and SIRS. Here, we investigated the direct role of circulating myeloid-EVs in ALI using a mouse isolated perfused lung system and a human cell coculture model of pulmonary vascular inflammation consisting of lung microvascular endothelial cells and peripheral blood mononuclear cells. Total and immunoaffinity-isolated myeloid (CD11b+) and platelet (CD41+) EVs were prepared from the plasma of i.v. LPS-injected endotoxemic donor mice and transferred directly into recipient lungs. Two-hour perfusion of lungs with unfractionated EVs from a single donor induced pulmonary edema formation and increased perfusate levels of receptor for advanced glycation end products (RAGE), consistent with lung injury. These responses were abolished in the lungs of monocyte-depleted mice. The isolated myeloid- but not platelet-EVs produced a similar injury response and the acute intravascular release of proinflammatory cytokines and endothelial injury markers. In the in vitro human coculture model, human myeloid (CD11b+) but not platelet (CD61+) EVs isolated from LPS-stimulated whole blood induced acute proinflammatory cytokine production and endothelial activation. These findings implicate circulating myeloid-EVs as acute mediators of pulmonary vascular inflammation and edema, suggesting an alternative therapeutic target for attenuation of indirect ALI.
Dental caries in a Norwegian adult population, the HUNT4 oral health study; prevalence, distribution and 45-year trends

Abstract Objective To investigate dental caries prevalence amongst adults in Central Norway and assess changes over the last 45 years. Materials and methods The cross-sectional HUNT4 Oral Health Study was conducted in 2017-2019. A random sample of 4913 participants aged ≥19 years answered questionnaires and underwent clinical and radiographic examinations. Data were compared to findings from previous studies in the same region conducted from 1973 to 2006. Results Mean number of decayed, missing and filled teeth (D3-5MFT) was 14.9 (95% CI 14.7, 15.1), 56% of adults had one or more carious teeth (D3-5T) and 11.8% had ≥4 D3-5T, with the mean number of 1.4 (95% CI 1.32, 1.42). For initial caries, mean D1-2S was 3.8 (95% CI 3.7, 3.9), being the highest for 19-24-year-olds at 8.6 (95% CI 7.9, 9.3). Comparisons with earlier studies showed a decline in mean D3-5MFT for 35-44-year-olds from 26.5 in 1973 to 10.8 in 2019. In 1973, 4.8% of 35-44-year-olds were edentulous, while in present study edentulousness was found only in individuals >65 years. Conclusions Despite a substantial reduction in caries experience over the last 45 years, untreated dentine caries was common, evenly distributed across all age groups. Initial caries particularly affected younger individuals, indicating a need to evaluate prevention strategies and access to dental services.
From real-world electronic health record data to real-world results using artificial intelligence

With the worldwide digitalisation of medical records, electronic health records (EHRs) have become an increasingly important source of real-world data (RWD). RWD can complement traditional study designs because it captures almost the complete variety of patients, leading to more generalisable results. For rheumatology, these data are particularly interesting as our diseases are uncommon and often take years to develop. In this review, we discuss the following concepts related to the use of EHR for research and considerations for translation into clinical care: EHR data contain a broad collection of healthcare data covering the multitude of real-life patients and the healthcare processes related to their care. Machine learning (ML) is a powerful method that allows us to leverage a large amount of heterogeneous clinical data for clinical algorithms, but requires extensive training, testing, and validation. Patterns discovered in EHR data using ML are applicable to real life settings, however, are also prone to capturing the local EHR structure and limiting generalisability outside the EHR(s) from which they were developed. Population studies on EHR necessitates knowledge on the factors influencing the data available in the EHR to circumvent biases, for example, access to medical care, insurance status. In summary, EHR data represent a rapidly growing and key resource for real-world studies. However, transforming RWD EHR data for research and for real-world evidence using ML requires knowledge of the EHR system and their differences from existing observational data to ensure that studies incorporate rigorous methods that acknowledge or address factors such as access to care, noise in the data, missingness and indication bias.
“This is how I want it”: Exploring the use of a workbook with persons with dementia to support advance care planning engagement

This mixed method sequential study reports focus group and pilot intervention findings that (1) explore the views of persons with dementia and their caregivers on using a self-directed advance care planning engagement workbook (Your Conversation Starter Kit) and (2) uncover the conditions that encouraged and hindered workbook use. In Phase 1, we conducted five focus groups consisting of 10 persons with dementia and eight family members/caregivers from two urban Canadian cities to explore overall impressions of the workbook and factors that might affect its use. In Phase 2, we empirically explored the factors identified in Phase 1 by distributing the workbook to 24 persons with dementia. The combined findings suggest that the workbook offers promise in supporting advance care planning engagement for persons with dementia in the early stages of their condition. Involving family/caregivers and clarifying some of the ranked questions might improve the workbook’s use. Persons with dementia without familial support or those who have never contemplated advance care planning may require additional guidance prior to workbook distribution.
Self‐efficacy in managing post‐treatment care among oral and oropharyngeal cancer survivors

Abstract Objective Physical and psychosocial effects of oral cancer result in long‐term self‐management needs. Little attention has been paid to survivors' self‐efficacy in managing their care. Study goals were to characterise self‐care self‐efficacy and evaluate socio‐demographics, disease, attitudinal factors and psychological correlates of self‐efficacy and engagement in head and neck self‐exams. Methods Two hundred thirty‐two oral cancer survivors completed measures of socio‐demographics, self‐care self‐efficacy, head and neck self‐exams and attitudinal and psychological measures. Descriptive statistics characterised self‐efficacy. Hierarchical regressions evaluated predictors of self‐efficacy. Results Survivors felt moderately confident in the ability to manage self‐care (M = 4.04, SD = 0.75). Survivors with more comorbidities (β = −0.125), less preparedness (β = 0.241), greater information (β = −0.191), greater support needs (β = −0.224) and higher depression (β = −0.291) reported significantly lower self‐efficacy. Head and neck self‐exam engagement (44% past month) was relatively low. Higher preparedness (OR = 2.075) and self‐exam self‐efficacy (OR = 2.606) were associated with more engagement in self‐exams. Conclusion Many survivors report low confidence in their ability to engage in important self‐care practices. Addressing unmet information and support needs, reducing depressive symptoms and providing skill training and support may boost confidence in managing self‐care and optimise regular self‐exams.
One-Year Mental and Physical Health Assessment in Survivors after Extracorporeal Membrane Oxygenation for COVID-19–related Acute Respiratory Distress Syndrome

Rationale Long-term outcomes of patients with coronavirus disease (COVID-19)–related acute respiratory distress syndrome treated with extracorporeal membrane oxygenation (ECMO) are unknown. Objectives To assess physical examination, pulmonary function tests, anxiety, depression, post-traumatic stress disorder and quality of life at 6 and 12 months after ECMO onset. Methods Multicenter, prospective study in patients who received ECMO for COVID-19 acute respiratory distress syndrome from March to June 2020 and survived hospital discharge. Measurements and Main Results Of 80 eligible patients, 62 were enrolled in seven French ICUs. ECMO and invasive mechanical ventilation duration were 18 (11–25) and 36 (27–62) days, respectively. All were alive, but only 19/50 (38%) returned to work and 13/42 (31%) had recovered a normal sex drive at 1 year. Pulmonary function tests were almost normal at 6 months, except for DlCO, which was still impaired at 12 months. Mental health, role-emotional, and role-physical were the most impaired domain compared with patients receiving ECMO who did not have COVID-19. One year after ICU admission, 19/43 (44%) patients had significant anxiety, 18/43 (42%) had depression symptoms, and 21/50 (42%) were at risk for post-traumatic stress disorders. Conclusions Despite the partial recovery of the lung function tests at 1 year, the physical and psychological function of this population remains impaired. Based on the comparison with long-term follow-up of patients receiving ECMO who did not have COVID-19, poor mental and physical health may be more related to COVID-19 than to ECMO in itself, although this needs confirmation.
Self-esteem in sexual minority young adults: a qualitative interview study exploring protective factors and helpful coping responses

Abstract Research on mental health inequalities between sexual minority and heterosexual young adults has historically focussed on the additional stress processes that might explain this disparity. However, more recently there has been a shift towards research focussed on resilience factors that might promote mental health in sexual minority young adults. Self-esteem is one such proposed resilience factor. This study aimed to explore the factors that promote or protect self-esteem itself in sexual minority young adults. A semi-structured interview study was conducted with 20 sexual minority young adults (aged 16–24) to explore their perspectives on the factors, responses and strategies that have helped to protect or promote their self-esteem. Six themes were identified from thematic analysis: helpful responses to minority stress; sexuality acceptance; positive LGBTQ + social connections and representations; positive social relationships and evaluation; successes and positive qualities and general coping strategies for low self-esteem. Findings are discussed in terms of their theoretical implications.
Visual essentialism and the object of visual culture

The double question whether visual culture studies is a discipline or an interdisciplinary movement, and which methods are most suited to practice in this field, can only be addressed by way of the object. This article probes the difficulty of defining or delimiting the object of study without the reassuring and widespread visual essentialism that, in the end, can only be tautological.
Accuracy of the Surface Contour of Three-Dimensional-Printed Canine Pelvic Replicas.

OBJECTIVE The aim of this study was to determine the differences in surface contour between models of native pelvic bones and their corresponding three-dimensional (3D)-printed replicas. STUDY DESIGN Digital 3D models of five cadaveric hemipelves and five live dogs with contralateral pelvic fractures were generated based on computed tomographic images and 3D printed. The 3D-printed replicas underwent 3D scanning and digital 3D models of the replicas were created. The digital 3D model of each replica was superimposed onto the model of the native hemipelvis. Errors in the replicas were determined by comparing the distances of 120,000 corresponding surface points between models. The medial surface, lateral surface and dorsal surface of the acetabulum (DSA) of each hemipelvis were selected for further analysis. The root mean square error (RMSE) was compared between various selected areas using a one-way repeated measures analysis of variance, followed by a Bonferroni post-hoc test. RESULTS The RMSE of the hemipelvis was 0.25 ± 0.05 mm. The RMSE significantly decreased from the medial surface (0.28 ± 0.06mm), to the lateral surface (0.23 ± 0.06mm), to the DSA (0.04 ± 0.02mm) (p < 0.001). CONCLUSION The 3D-printed replicas were adequate in serving as a template for the pre-contouring of bone plates in fracture repair of pelvic fractures, particularly those that demand accurate reduction such as acetabular fractures.
Estimation of greenhouse gas emissions from Iran's gas flaring by using satellite data and combustion equations

In addition to the waste of resources and economic losses, environmental damage by gas flaring is widespread and significant. Since flaring the associated gas gives no added value in exchange for its pollution and greenhouse gas (GHG) emissions, it could be identified as a top priority for mitigation. Iran is the third gas flaring country after Russia and Iraq among those facing this issue, and is responsible for 12.1% of the world's gas flaring. While the necessity of developing a method for the precise estimation of flaring GHG emissions is clear, especially for evaluating the result of countries' efforts to meet their nationally determined contribution target, there are huge uncertainties and discrepancies in the values of emission factors among various data sources due to the lack of actual measurements of the volume and diversity of the composition of flare gas. This study aimed to fill the gap in providing authentic data on Iran's gas flaring GHG and air pollutant emissions by developing a model based on satellite data on flare volumes, gas compositions, and combustion equations. Our results revealed that based on 2021 data on flaring volume, Iranian gas flares are emitting approximately 50 million metric tons of CO2 equivalent to the atmosphere annually, which could be reduced to 43 by only enhancing the flares' efficiency. It accounted for 5.5%–6% of the total GHG emissions of the country. Integr Environ Assess Manag 2023;19:735–748. © 2022 SETAC.
Study of CP Violating Effects in Time Dependent $B^0(\bar{B^0}) \to D^{(*)\mp}π^{\pm}$ Decays

We report measurements of time dependent decay rates for $B^0(\bar{B}^0) \to D^{(*)\mp}\pi^{\pm}$ decays and extraction of CP violation parameters containing $\phi_3$. Using fully reconstructed $D^{(*)}\pi$ events from a $140 {\rm fb}^{-1}$ data sample collected at the $\Upsilon(4S)$ resonance, we obtain the CP violation parameters for $D^* \pi$ and $D \pi$ decays, $2R_{D^{(*)} \pi} \sin (2\phi_1 + \phi_3 \pm \delta_{D^{(*)} \pi})$, where $R_{D^{(*)} \pi}$ is the ratio of the magnitudes of the doubly-Cabibbo-suppressed and Cabibbo-favoured amplitudes, and $\delta_{D^{(*)} \pi}$ is the strong phase difference between them. Under the assumption of $\delta_{D^{(*)} \pi}$ being close to either 0 or $180^{\circ}$, we obtain $|2R_{D^* \pi} \sin (2\phi_1 + \phi_3)| = 0.060 \pm 0.040(\mathrm{stat}) \pm 0.019(\mathrm{sys})$ and $|2R_{D \pi} \sin (2\phi_1 + \phi_3)| = 0.061 \pm 0.037(\mathrm{stat}) \pm 0.018(\mathrm{sys})$.
Investigation of the organic solar cell characteristics for indoor LED light applications

We report an experimental study on the current–voltage characteristics of organic solar cells (OSCs) under indoor light illumination. A daylight color light-emitting diode (LED) was used as the indoor light source. We investigated the short circuit current density, open circuit voltage, and fill factor of the OSC under LED irradiation and compared them with those for a crystal silicon solar cell (c-Si-SC), which occupy a large part of the solar cell market. We found that compared with the c-Si-SC, the OSC had higher power conversion efficiency (PCE). We also derived the maximum feasible PCE of an OSC for indoor applications and calculated that a PCE value of 21.3% could be obtained under daylight color LED illumination at approximately 200 lx. From the results of the calculation, it became apparent that the open circuit voltage plays an important role in achieving a high PCE from OSCs, indicating they are promising as electrical energy harvesting module for indoor applications.
How biogenic polymers control surfactant dynamics in the surface microlayer: insights from a coastal Baltic Sea study

Abstract. Surfactants can hamper gas exchange by up to 50 % in coastal seas; however, their small-scale temporal and spatial dynamics are poorly constrained. This study investigated possible biogenic sources of surfactants in the sea surface microlayer (SML) and the underlying water at a coastal Baltic Sea site. To relate surfactant dynamics to biogenic production, we conducted two field studies (June and September 2018) and focused on amino acids and carbohydrates as the main components of organic matter derived from phytoplankton. Furthermore the composition of the biochemicals provided insights into microbial degradation dynamics and was complemented by flow-cytometry-based community analysis. In total, 76 samples were collected within an area of approximately 50 km2, allowing for high spatial resolution. Moreover, morning and afternoon sampling enabled us to investigate diel cycles. Our results reveal that surfactant concentrations were tightly coupled to the abundance of nano-phytoplankton and generally higher in September than in June, with cell abundance 3 times higher. Surfactant concentration in June was best explained by the combined effect of the particulate fraction of the non-essential amino acid serine, the concentration of particulate combined carbohydrates (PCHO), and dissolved organic carbon (DOC). Surfactant and PCHO concentrations were significantly enriched in the SML and followed a pronounced diel cycle, possibly linked to microbial processing and/or photo-processing. In contrast to June, the surfactant pool in September correlated to a diverse mixture of semi-labile organic matter components, represented best by dissolved glucose and the essential amino acid isoleucine. We conclude that the surfactant pool in surface seawater is mainly composed of organic matter components that resist rapid microbial degradation. Elevated surfactant concentrations are triggered by the release of fresh organic matter. While the effect of the resistant but less surface-active stock is potentially longer-lasting, the additive effect of labile, highly surface-active agents on gas exchange may diminish on short timescales.
Kinetics of Evaporation: Statistical Rate Theory Approach

Currently there are three theoretical approaches to study evaporation: Continuum Mechanics, Classical Kinetic Theory, and recently Statistical Rate Theory (SRT). The assumptions being used and the predictions resulting from the first two methods have not been supported by experimental results which are in agreement with the SRT predictions. It seems that SRT can predict the conditions existing at the interface during evaporation better than other methods. This paper reviews some of the published evaporation studies, particularly evaporation rate, thermocapillary convection, and temperature discontinuity at the interface during evaporation and compares the results of different approaches.
Schrodinger Operators: With Application to Quantum Mechanics and Global Geometry

Self-Adjointness. - Lp-Properties of Eigenfunctions, and All That. - Geometric Methods for Bound States. - Local Commutator Estimates. - Phase Space Analysis of Scattering. - Magnetic Fields. - Electric Fields. - Complex Scaling. - Random Jacobi Matrices. - Almost Periodic Jacobi Matrices. - Witten's Proof of the Morse Inequalities. - Patodi's Proof of the Gauss-Bonnet-Chern Theorem and Superproofs of Index Theorems. - Bibliography. - List of Symbols. - Subject Index.