Miracle-dz/UniFAR-FTUs huggingface dataset:
Dimensions of Caregiver Burden between Compound and Noncompound Caregivers of Adults with Autism

ABSTRACT The expanding population of adults with autism spectrum disorder (ASD) will increase the number of aging parents who often assume the role of primary caregivers. Among aging caregivers of adults with ASD, compound caregiving (caring for additional family members) has become an increasingly common scenario. However, limited research has examined the burden of compound caregivers and little is known about the specific dimensions of burden among this population. The present study aims to compare differences between compound 1, compound 2, and noncompound caregivers on specific dimensions of caregiver burden associated with adult children with ASD. Using a cross-sectional design, data were collected from 320 caregivers aged 50 and older through a web-based survey. Four dimensions of burden (time dependence, developmental, emotional, and financial) were compared using MANOVA. Compound 1 and noncompound caregivers experienced lower levels of time dependence burden than compound 2 caregivers. In terms of developmental burden, the social life of compound 2 caregivers was more affected by caregiving compared to noncompound caregivers. The findings have practice implications for identifying caregivers’ multiple responsibilities and the multi-faceted impact of caregiving, and prioritizing interventions for compound caregivers and its subpopulations to reduce their time and developmental burden.
Environmental Sampling for Avian Influenza Virus Detection in Commercial Layer Facilities

SUMMARY. The present study was designed to evaluate the utility of environmental samples for convenient but accurate detection of avian influenza virus (AIV) in commercial poultry houses. First, environmental samples from AIV-negative commercial layer facilities were spiked with an H5N2 low pathogenic AIV and were evaluated for their effect on the detection of viral RNA immediately or after incubation at –20 C, 4 C, 22 C, or 37 C for 24, 48, or 72 hr. Second, Swiffer pads, drag swabs, and boot cover swabs were evaluated for their efficiency in collecting feces and water spiked with the H5N2 LPAIV under a condition simulated for a poultry facility floor. Third, environmental samples collected from commercial layer facilities that experienced an H5N2 highly pathogenic AIV outbreak in 2014–15 were evaluated for the effect of sampling locations on AIV detection. The half-life of AIV was comparable across all environmental samples but decreased with increasing temperatures. Additionally, sampling devices did not differ significantly in their ability to collect AIV-spiked environmental samples from a concrete floor for viral RNA detection. Some locations within a poultry house, such as cages, egg belts, house floor, manure belts, and manure pits, were better choices for sampling than other locations (feed trough, ventilation fan, and water trays) to detect AIV RNA after cleaning and disinfection. Samples representing cages, floor, and manure belts yielded significantly more PCR positives than the other environmental samples. In conclusion, environmental samples can be routinely collected from a poultry barn as noninvasive samples for monitoring AIV.
Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications

Abstract Context Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications. Objective We aimed to assess whether kisspeptin levels are altered in women with antenatal complications. Methods Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed. Results Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P < 0.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P = 0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P = 0.014) and lower in those with GDM (P = 0.020), but not significantly on multivariable analysis. Conclusion We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.
Does omitting the accent mark in a word affect sentence reading? Evidence from Spanish

Lexical stress in multisyllabic words is consistent in some languages (e.g., first syllable in Finnish), but it is variable in others (e.g., Spanish, English). To help lexical processing in a transparent language like Spanish, scholars have proposed a set of rules specifying which words require an accent mark indicating lexical stress in writing. However, recent word recognition using that lexical decision showed that word identification times were not affected by the omission of a word’s accent mark in Spanish. To examine this question in a paradigm with greater ecological validity, we tested whether omitting the accent mark in a Spanish word had a deleterious effect during silent sentence reading. A target word was embedded in a sentence with its accent mark or not. Results showed no reading cost of omitting the word’s accent mark in first-pass eye fixation durations, but we found a cost in the total reading time spent on the target word (i.e., including re-reading). Thus, the omission of an accent mark delays late, but not early, lexical processing in Spanish. These findings help constrain the locus of accent mark information in models of visual word recognition and reading. Furthermore, these findings offer some clues on how to simplify the Spanish rules of accentuation.
Coupled Cluster and Density Functional Studies of Atomic Fluorine Chemisorption on Coronene as Model Systems for Graphene Fluorination

Potential energy curves (PECs) of atomic fluorine adsorption on coronene as a model for graphene or nanocarbon surfaces have been computed. The PECs were obtained by scanning the fluorine atom distance to one of the center carbon atoms of the coronene molecule as model system in a “top” position from 4.0 to1.0 A in intervals of 0.1 A using a variety of quantum chemical methods. Various density functional theory (DFT) functionals, such as B3LYP, PBE, PBE0, CAM-B3LYP, and LC-ωPBE; approximate DFT methods such as several levels of the density-functional tight-binding (DFTB) method, as well as ab initio wave function theory methods such as MP2, CCSD, CCSD(T), and G2MS extrapolations, were used to evaluate energies for B3LYP/cc-pVDZ PEC geometries. G2MS is an approximation to the highly accurate CCSD(T)/cc-pVTZ level of theory in our work. We found that fluorine is chemically adsorbed on coronene with a binding energy of 22.9 and 23.3 kcal/mol at the B3LYP/cc-pVDZ and G2MS levels of theory, respectively, and 1.
Lessons Learned: Creation and Testing of a New Instrument (Sex Offenders Grooming Assessment) for Measuring Sex Offenders’ Perceptions of Their Grooming Behaviors

ABSTRACT Grooming is a process whereby an individual who plans to commit a sexual crime uses deception with the victim as well as the people in the environment (such as the victim’s family members, the offender’s family, etc.) so that the crime goes undetected. Despite the overwhelming presence of grooming in sexual crimes, there is a dearth of research on sex offenders’ perceptions of their own grooming behaviors. This paper describes the psychometrics and lessons learned in the pilot study of testing and revising a new instrument for measuring sex offenders’ perceptions of their grooming behaviors (Sex Offenders Grooming Assessment; SOGA), with a sample (n = 50) of convicted male sex offenders in community based specialized therapy. Analyses suggest that using behaviorally-specific questions yielded more reliable results than general categorical grooming questions. Understanding how sex offenders perceive and report their grooming behavior provides valuable insight critical to treatment and assessment.
Normative values of visual evoked potential in adults

Purpose: Visual evoked potentials (VEP) are used to determine the function of visual pathway from the optic nerve to visual cortex. Various factors may affect VEP response, viz., technical and environmental. The aim of this study is to obtain the normative value of VEP latency and amplitude parameters in adulthood in Indonesia, as well as the relationship of height, weight, body mass index (BMI), head circumference, and visual acuity with the variety of latency and amplitude values of VEP parameters. Methods: It is a cross-sectional study on 120 healthy subjects consisting of 60 males and 60 females between 18 and 65 years old. Height, weight, BMI, head circumference, and visual acuity were measured and continued with VEP examination using a 26′ checkerboard pattern on the left and right eyes alternately. All data were collected and analyzed with the Shapiro–Wilk test using statistical software R version 3.5. 2. Results: Mean value of P100 latency (interocular latency) of left and right eye were 104.6 ± 3.4 ms and 104.1 ± 3.4 ms, respectively, as well as 9.8 ± 4.7 μV and 10.3 ± 5.4 μV for the amplitude. There was no significant difference between the male and female group, as well as on the age group. Female significantly exhibited a higher P100 amplitude than male. The greater the age, the lower amplitude of P100 significantly. Conclusion: Gender and age do not affect the P100 latency value but only affect P100 amplitude. Height, weight, BMI, head circumference, and visual acuity also do not affect the P100 latency and amplitude.
Adaptive Neural Control of Nonlinear Nonstrict Feedback Systems With Full-State Constraints: A Novel Nonlinear Mapping Method

In this work, a neural-networks (NNs)-based adaptive asymptotic tracking control scheme is presented for a class of uncertain nonstrict feedback nonlinear systems with time-varying full-state constraints. First, we construct a novel exponentially decaying nonlinear mapping to map the constrained system states to new system states without constraints. Instead of the traditional barrier Lyapunov function methods, the feasible conditions which require the virtual control signals satisfying the constraint requirements are removed. By employing the Nussbaum design method to eliminate the effect of unknown control gains, the general assumption about the signs of the unknown control gains is relaxed. Then, the nonstrict feedback form of the system can be pulled back to the strict feedback form through the basic properties of radial basis function NNs. Simultaneously, the intermediate control signals and the desired controller are constructed by the backstepping process and the Nussbaum design method. The designed controller can ensure that all signals in the whole closed-loop system are bounded without the violation of the constraints and hold the asymptotic tracking performance. In the end, a practical example about a brush dc motor driving a one-link robot manipulator is given to illustrate the effectiveness of the proposed design scheme.
Relationship Between the Serotypes and Hemagglutinin Gene Sequences of Avibacterium paragallinarum

SUMMARY. Avibacterium paragallinarum has been subtyped into three serogroups (A, B, and C) and nine serovars (A-1, A-2, A-3, A-4, B-1, C-1, C-2, C-3, and C-4) according to the Page and Kume schemes. Both schemes use the hemagglutination inhibition test for serotyping. However, the relationship between the hemagglutinin gene (HMTp210) sequences and serotypes of A. paragallinarum is still unclear. This problem is partly due to the lack of information on the complete HMTp210 sequence from the formal reference strain of Page serogroup B (strain 0222 or Spross). In this study, we determined the complete HMTp210 sequence of strain Spross. The sequence of Spross and those of other HMTp210 sequences retrieved from GenBank were used to conduct phylogenetic analyses to investigate the relationship between the serotypes and HMTp210 sequences of A. paragallinarum. Four phylogenetic clusters, designated clusters A-1, A-2, B, and C, were identified. Clustering based on complete HMTp210 sequences correlates with serotyping based on hemagglutination inhibition tests. Serovar A-2 was found to contain a chimeric HMTp210 gene that might have resulted from recombination between serovar A-1 and serovar C-1. In addition, phylogenetic analysis based on partial sequences (approximately nucleotides 1–1200) of HMTp210 was sufficient to discriminate between serogroups A, B, and C. These findings could be valuable for developing a molecular method for serotyping of A. paragallinarum.
Function of K2P channels in the mammalian node of Ranvier

In myelinated nerve fibres, action potentials are generated at nodes of Ranvier. These structures are located at interruptions of the myelin sheath, forming narrow gaps with small rings of axolemma freely exposed to the extracellular space. The mammalian node contains a high density of Na+ channels and K+‐selective leakage channels. Voltage‐dependent Kv1 channels are only present in the juxta‐paranode. Recently, the leakage channels have been identified as K2P channels (TRAAK, TREK‐1). K2P channels are K+‐selective ‘background’ channels, characterized by outward rectification and their ability to be activated, e.g. by temperature, mechanical stretch or arachidonic acid. We are only beginning to elucidate the peculiar functions of nodal K2P channels. I will discuss two functions of the nodal K2P‐mediated conductance. First, at body temperature K2P channels have a high open probability, thereby inducing a resting potential of about −85 mV. This negative resting potential reduces steady‐state Na+ channel inactivation and ensures a large Na+ inward current upon a depolarizing stimulus. Second, the K2P conductance is involved in nodal action potential repolarization. The identification of nodal K2P channels is exciting since it shows that the nodal K+ conductance is not a fixed value but can be changed: it can be increased or decreased by a broad range of K2P modulators, thereby modulating, for example, the resting potential. The functional importance of nodal K2P channels will be exemplified by describing in more detail the function of the K2P conductance increase by raising the temperature from room temperature to 37°C.
Shape-centered representations of bounded regions of space mediate the perception of objects

ABSTRACT We report the study of a woman who perceives 2D bounded regions of space (“shapes”) defined by sharp edges of medium to high contrast as if they were rotated by 90, 180 degrees around their centre, mirrored across their own axes, or both. In contrast, her perception of 3D, strongly blurred or very low contrast shapes, and of stimuli emerging from a collection of shapes, is intact. This suggests that a stage in the process of constructing the conscious visual representation of a scene consists of representing mutually exclusive bounded regions extracted from the initial retinotopic space in “shape-centered” frames of reference. The selectivity of the disorder to shapes originally biased toward the parvocellular subcortical pathway, and the absence of any other type of error, additionally invite new hypotheses about the operations involved in computing these “intermediate shape-centered representations” and in mapping them onto higher frames for perception and action.
Third Trimester Myocardial Performance Index in Fetuses from Women with Hyperglycemia in Pregnancy: A Systematic Review and Meta-Analysis

Abstract Introduction The myocardial performance index (MPI) has been proposed to evaluate cardiac dysfunction in newborns from diabetic mothers. Although MPI is routinely assessed in newborns, its role in the evaluation of fetuses from women with hyperglycemia in pregnancy (HIP) is still under evaluation. We aimed to evaluate the differences in third trimester fetal MPI in pregnant women with hyperglycemia compared to healthy controls. Materials and Methods Seven electronic databases were searched for all studies assessing women with HIP who underwent evaluation of fetal left MPI during pregnancy compared to a control group. The summary measures were reported as mean differences (MD) in the mean fetal left MPI between women with HIP and healthy controls, with a 95 % confidence interval (CI). A post hoc subgroup analysis based on the type of HIP – pregestational diabetes, GDM, or gestational impaired glucose tolerance (GIGT) – was performed as an additional analysis. Results 14 studies assessing 1326 fetuses (580 from women with HIP and 746 from controls) were included. Women with HIP had a significantly higher mean left fetal MPI compared to controls (MD 0.08; 95 %CI: 0.05 to 0.11; p < 0.00 001). Subgroup analysis according to the type of HIP concurred with the overall analysis for women with DM (MD 0.07; 95 %CI: 0.01 to 0.13; p = 0.02) and for women with GDM (MD 0.012; 95 %CI: 0.07 to 0.17; p < 0.00 001) but not for women with GIGT (MD –0.01, 95 % CI –0.28 to 0.27; p = 0.96). Conclusion Fetal left MPI is increased in pregnancies with HIP appearing as a potential marker of cardiac dysfunction.
ADAPTATIONS TO REHABILITATION SERVICES DURING THE COVID-19 PANDEMIC PROPOSED BY SCIENTIFIC AND PROFESSIONAL REHABILITATION ORGANIZATIONS

Objective To describe adaptations in the provision of rehabilitation services proposed by scientific and professional rehabilitation organizations to avoid interruptions to patients’ rehabilitation process and delays in starting rehabilitation in patients with COVID-19. Methods A narrative review approach was used to identify the recommendations of scientific and professional organizations in the area of rehabilitation. A systematic search was performed in the main data bases in 78 international and regional web portals of rehabilitation organizations. A total of 21 publications from these organizations were identified and selected. Results The results are presented in 4 categories: adequacy of inpatient services, including acute care services and intensive care unit for patients with and without COVID-19; adequacy of outpatient services, including home-based rehabilitation and tele- rehabilitation; recommendations to prevent the spread of COVID-19; and regulatory standards and positions during the COVID-19 pandemic expressed by organizations for protecting the rights of health workers and patients. Conclusion Health systems around the world are rapidly learning from actions aimed at the reorganization of rehabilitation services for patients who are in the process of recovery from acute or chronic conditions, and the rapid response to the rehabilitation of survivors of COVID-19, as well as from efforts in the prevention of contagion of those providing the services. LAY ABSTRACT In response to the coronavirus disease 2019 (COVID-19) pandemic, which developed very rapidly worldwide, rehabilitation services were forced to modify and adapt the way they provide and deliver services. These measures were proposed and adopted across a wide range of countries, the changes proposed included the following measures: critical patients with SARS-CoV-2 infection should be cared for by a multidisciplinary team providing early mobilization, respiratory, outpatient, and long-term care rehabilitation interventions. Home- based and community rehabilitation can be delivered through different strategies, such as telerehabilitation or direct care. The use of measures to prevent and protect against transmission of COVID-19 are necessary for all patients in rehabilitation care.
Involvement of extracellular vesicles in aging process and their beneficial effects in alleviating aging‐associated symptoms

Aging is a gradual and unavoidable physiological phenomenon that manifests in the natural maturation process and continues to progress from infanthood to adulthood. Many elderly people suffer from aging‐associated hematological and nonhematological disorders. Recent advances in regenerative medicine have shown new revolutionary paths of treating such diseases using stem cells; however, aging also affects the quality and competence of stem and progenitor cells themselves and ultimately directs their death or apoptosis and senescence, leading to a decline in their regenerative potential. Recent research works show that extracellular vesicles (EVs) isolated from different types of stem cells may provide a safe treatment for aging‐associated disorders. The cargo of EVs comprises packets of information in the form of various macromolecules that can modify the fate of the target cells. To harness the true potential of EVs in regenerative medicine, it is necessary to understand how this cargo contributes to the rejuvenation of aged stem and progenitor populations and to identify the aging‐associated changes in the macromolecular profile of the EVs themselves. In this review, we endeavor to summarize the current knowledge of the involvement of EVs in the aging process and delineate the role of EVs in the reversal of aging‐associated phenotypes. We have also analyzed the involvement of the molecular cargo of EVs in the generation of aging‐associated disorders. This knowledge could not only help us in understanding the mechanism of the aging process but could also facilitate the development of new cell‐free biologics to treat aging‐related disorders in the future.
Changes in corneal curvature and visual acuity in North Indian adults after pterygium excision with modified sutureless, glueless limbal-conjunctival autograft

Purpose: To identify the exact time point during after following pterygium excision with a modified technique of sutureless, glueless limbal-conjunctival autograft, when stabilization of the change in corneal curvature is achieved; correlate size of pterygium with uncorrected visual acuity and astigmatism at baseline, and assess changes in these parameters postoperatively over time. Methods: This prospective study longitudinally assessed 30 eyes of 30 north Indian adults with primary pterygium encroaching upon ≥1 mm of the cornea pre- and postoperatively at 1 week and then monthly for 4 months, recording uncorrected (UCVA) and best-corrected logMAR visual acuity, astigmatism and keratometry. Results were analyzed using ANOVA, Mauchly's test of sphericity with Greenhouse–Geisser correction, and post-hoc test using Bonferroni correction. Pearson's correlation coefficient r > 0.5 was considered clinically significant, and P < 0.05 statistically significant. Results: Pterygium size was well correlated with pre-operative astigmatism (r = 0.867, P < 0.001) and pre-operative UCVA (r = 0.856, P < 0.001). There was mean improvement of 0.43 logMAR units of visual acuity (P < 0.00001), a mean increase of 0.79D of keratometric value for the flatter meridian (P < 0.00001) and a mean reduction of 2.00D of astigmatism (P < 0.00001). At 2-month follow-up, the keratometric value for the flatter meridian approached the final keratometric reading at 4 months such that the difference was not significant (t = 1.185, P = 0.245). There were no significant complications or recurrence during the follow-up period. Conclusion: Pterygium excision with modified autograft reduced corneal astigmatism and improved visual acuity comparable to classical technique. Alteration in corneal curvature stabilizes 2 months after surgery, when spectacle correction can be given to patients.