Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Entrepreneurial Culture and Sustainable Competitive Advantage in the Banking Sector

Business sustainability of services-rendering organisations is one of the major concerns for those at managerial levels world-wide. This paper offers explanations on how best to achieve sustainable competitive advantage by communicating entrepreneurial values through human resource development programmes in the banking industry. The research reported in this paper adopted a non-experimental research design of ex post facto type, utilising a correlational approach with advanced explanatory design. Based on the principle of convenience sampling, 380 questionnaires were distributed to employees of two Nigerian banks. Three hypotheses were formulated and tested using inferential statistics via two statistical software packages: the IBM Statistical Package for Social Science (SPSS) version 23 and the IBM SPSS Analysis of Moment Structure (AMOS) version 23. The results show that human resource development partially mediates the relationship between entrepreneurial culture and sustainable competitive advantage in the Nigerian banking sector. The results suggest an enhancement of entrepreneurial values through continuous learning and development programmes toward sustainable competitive advantage. It is recommended that sustainability of banks operating in Nigeria could be enhanced by communicating and managing entrepreneurial orientations through effective learning and development programmes. Ambidextrous banks will require creativity, innovation and proactive capabilities in the process of exploiting and exploring both current and future business opportunities for sustained competitive advantage.
The relationship between entrepreneurial orientation, market orientation, learning orientation, technology orientation and SMEs performance in Nigeria

In spite of the recognized significant contribution of SMEs to the nations’ economy, Nigerian SMEs performance is below expectation. Their low contribution to GDP and employment shows this gross under performance.Moreover, the SMEs high failure rate is another indication of their low performance.Hence, past literature's suggest that strategic orientations have a significant effect on firm performance, even though most of the studies concentrated on investigating one or two strategic orientation at a time.Research on the combination of these important strategic orientations in a single model is scarce, and there is paucity about the best orientations to be adopted.The objective of this study is to investigate the positive influence of entrepreneurial orientation, market orientation, learning orientation, and technology orientation on SMEs performance in Nigeria.A cross-sectional study of questionnaire survey research design was conducted and data was generated from 362 usable questionnaires of owner-managers of small firms.To conduct the analysis, the study applies PLS-SEM to understand the positive effects of entrepreneurial, market, learning and technology orientations on the performance of SMEs in Nigeria.The results indicate that entrepreneurial, learning and technology orientations have positive affect on performance, however, in this context, the result do not support the view that market orientation positively affect firm performance.Essentially, the findings suggest that SMEs need to combine their entrepreneurial ability with learning from their environment and adopting new technology trends in the markets.
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

Introduction: The cannabinoid receptor (CBR) subtypes 1 (CB1R) and 2 (CB2R) are key components of the endocannabinoid system (ECS), playing a central role in the control of peripheral pain, inflammation and the immune response, with further roles in the endocrine regulation of food intake and energy balance. So far, few medicines targeting these receptors have reached the clinic, suggesting that a better understanding of the receptor signalling properties of existing tool compounds and clinical candidates may open the door to the development of more effective and safer treatments. Both CB1R and CB2R are Gαi protein-coupled receptors but detecting Gαi protein signalling activity reliably and reproducibly is challenging. This is due to the inherent variability in live cell-based assays and restrictions around the use of radioactive [35S]-GTPγS, a favoured technology for developing higher-throughput membrane-based Gαi protein activity assays. Methods: Here, we describe the development of a membrane-based Gαi signalling system, produced from membrane preparations of HEK293TR cells, stably overexpressing CB1R or CB2R, and components of the Gαi-CASE biosensor. This BRET-based system allows direct detection of Gαi signalling in both cells and membranes by monitoring bioluminescence resonance energy transfer (BRET) between the α and the βγ subunits. Cells and membranes were subject to increasing concentrations of reference cannabinoid compounds, with 10 μM furimazine added to generate RET signals, which were detected on a PHERAstar FSX plate reader, then processed using MARS software and analysed in GraphPad PRISM 9.2. Results: In membranes expressing the Gi-CASE biosensor, the cannabinoid ligands profiled were found to show agonist and inverse agonist activity. Agonist activity elicited a decrease in the BRET signal, indicative of receptor activation and G protein dissociation. Inverse agonist activity caused an increase in BRET signal, indicative of receptor inactivation, and the accumulation of inactive G protein. Our membrane-based Gi-CASE NanoBRET system successfully characterised the potency (pEC50) and efficacy (Emax) of CBR agonists and inverse agonists in a 384-well screening format. Values obtained were in-line with whole-cell Gi-CASE assays and consistent with literature values obtained in the GTPγS screening format. Discussion: This novel, membrane-based Gαi protein activation assay is applicable to other Gαi-coupled GPCRs, including orphan receptors, allowing real-time higher-throughput measurements of receptor activation.
Clinical utility of adjunctive retigabine in partial onset seizures in adults

: In ∼ 30% of epileptic patients, full seizure control is not possible, which is why the search for novel antiepileptic drugs continues. Retigabine exhibits a mechanism of action that is not shared by the available antiepileptic drugs. This antiepileptic enhances potassium currents via Kv7.2–7.3 channels, which very likely results from destabilization of a closed conformation or stabilization of the open conformation of the channels. Generally, the pharmacokinetics of retigabine are linear and the drug undergoes glucuronidation and acetylation. Results from clinical trials indicate that, in the form of an add-on therapy, retigabine proves an effective drug in refractory epileptic patients. The major adverse effects of the add-on treatment are dizziness, somnolence, and fatigue. This epileptic drug is also considered for other conditions – neuropathic pain, affective disorders, stroke, or even Alzheimer’s disease.
Tunneled antibiotic-impregnated vs. bolt-connected, non-coated external ventricular drainage: a comparison of complications

Background External ventricular drainage (EVD) is a common emergency neurosurgical procedure, but it is not free of adverse events. The aim of this study is to compare the complication rate of two frequently used EVD types, namely, tunneled antibiotic-impregnated catheters (Bactiseal©) and bolt-connected non-coated devices (Camino©). Methods All EVDs placed between 1 March 2015 and 31 December 2017 were registered. Procedures performed with any catheter different from Bactiseal© or Camino© EVD with incomplete follow-up and those EVDs placed due to infectious disease were excluded. Demographic and clinical variables, as well as the overall complication rate (infection, hemorrhage, obstruction, malposition of the catheter, and involuntary pull-out of the device) and the need for replacement of the EVD, were collected. Results A total of 77 EVDs were finally considered for analysis (40 Bactiseal® and 37 Camino®). There was a statistically significant difference in diagnosis and also in the location of the procedure, as more bolt-connected EVD was placed outside the operating room (97.3 vs. 23.5%, p < 0.001) due to emergent pathologies such as vascular diseases and spontaneous hemorrhages. In the univariate analysis, a statistically significantly higher rate of catheter involuntary pull-out (29.7 vs. 7.5%, p = 0.012) and the need for EVD replacement (32.4 vs. 12.5%, p = 0.035) was found in the Camino cohort. However, those differences could not be confirmed with multivariable analysis, which showed no association between the type of catheter and any of the studied complications. Ventriculostomy duration was identified as a risk factor for infection (OR 1.09, 95% CI 1.02–1.18). Conclusion No significant differences were observed regarding infection, hemorrhage, obstruction, malposition, involuntary catheter pull-out, and the need for EVD replacement when comparing non-impregnated bolt-connected EVDs (Camino®) with tunneled antibiotic-impregnated catheters (Bactiseal®). The duration of EVD was associated with an increased risk of infection.
Anti-diabetic combination therapy with pioglitazone or glimepiride added to metformin on the AGE-RAGE axis: a randomized prospective study

Introduction The ratio between advanced glycation end products (AGEs) and soluble form of receptor (s-RAGE) has been proposed as a risk marker for renal and cardiovascular diseases. The aim of this study was to evaluate in the diabetes condition the influence of two different oral anti-diabetic treatments on the AGE/s-RAGE ratio, during a 5-year observation period. Methods Seventy-three patients with type 2 diabetes mellitus were randomly assigned to a drug therapy with pioglitazone or glimepiride, combined to metformin. Each subject was evaluated at baseline and after 5 years of treatment. Results In both groups s-RAGE levels did not significantly vary, while the levels of AGE and AGE/s-RAGE were both significantly reduced, basal compared to 5-year values. Within pioglitazone group, as well within glimepiride group, significant variations (Δ, as difference between 5 years of treatment minus basal) were observed for AGE (Δ= ˗21.1±13.4 µg/ml, P<0.001 for pioglitazone; Δ= ˗14.4±11.4 µg/ml, P<0.001 for glimepiride) and in AGE/s-RAGE (Δ= -0.037±0.022 µg/pg, P<0.001 for pioglitazone; Δ= -0.024±0.020µg/pg, P<0.001 for glimepiride), suggesting an average decrease of the parameters by more than 50% in both treatments. Pioglitazone was more effective than glimepiride in reducing AGE/s-RAGE ratio after 5 years of therapy. Conclusion These data can help to explain the benefits of oral anti-diabetic therapy in relation to the reduction of cardiovascular risk, as suggested by variations in AGE/s-RAGE ratio as biochemical marker of endothelial function; in particular, treatment with pioglitazone seems to offer greater long-term benefit on AGE-RAGE axis.
SubMix: Learning to Mix Graph Sampling Heuristics

Sampling subgraphs for training Graph Neural Networks (GNNs) is receiving much attention from the GNN community. While a variety of meth-ods have been proposed, each method samples the graph according to its own heuristic. However, there has been little work in mixing these heuristics in an end-to-end trainable manner. In this work, we design a generative framework for subgraph sampling. Our method, SubMix, parame-terizes subgraph sampling as a convex combination of heuristics. We show that a continuous approximation of the discrete sampling process allows us to efﬁciently obtain analytical gradients for training the sampling parameters. Our experimental results illustrate the usefulness of learning graph sampling in three scenarios: (1) robust training of GNNs by automatically learning to discard noisy edge sources; (2) improving model performance by trainable and online edge subset selection; and (3) by integrating our framework into decoupled GNN models improves their performance on standard benchmarks.
Optimal control of partially unknown constrained‐input systems: A dynamic event‐triggered‐based approach

This article presents an identifier‐based dynamic event‐triggered optimal control scheme for partially unknown constrained‐input systems. First, an event‐triggered‐based neural network (NN) identifier is constructed to estimate the unknown system dynamics. Then, an adaptive dynamic programming algorithm with actor‐critic NN structure is adopted to obtain an approximate solution of the Hamilton–Jacobi–Bellman equation. The above considers that transmitted measurements are only available at the triggering instants, and the update of all three NN weights depends on the established dynamic event‐triggered mechanism. Different from existing static event‐triggered mechanism, the proposed dynamic event‐triggered mechanism can further obtain a reasonable trade‐off between performance and communication resources by introducing a dynamic variable, and the Zeno behavior can be excluded by devising an exponential term. It is proved that all the closed‐loop system signals are uniformly ultimately bounded under the established event‐triggered mechanism. Finally, two numerical examples are provided, including the spring‐mass‐damper system, to validate the proposed control scheme.
A halak mozgási aktivitásának hatása a kopoltyúhálós mintavételezések eredményeire: a CPUE napszakos és évszakos változásai a Balatonban: [Impacts of the activity of fish on the results of gillnet samplings: diurnal and seasonal changes of the CPUE in Lake Balaton.]

A halak gyűjtesehez alkalmazott modszerek lehetnek passziv es aktiv modszerek. Az aktiv halaszati modszerek (elektromos halaszat, vontatott halos halaszat) mellett vilagszerte gyakran alkalmazzak a kulonfele passziv halaszati modszereket, amelyek kozul talan legszelesebb korben a kopoltyuhalos halaszat terjedt el. A kopoltyuhalok alkalmazasanak előnye az egyszerű kezelhetőseg, a csekely eszkoz igeny es a mintavetel szelektivitasanak nagyfoku szabalyozhatosaga (kifogott halak merete, vizmelyseg stb.) (Hubert 1996). A kopoltyuhalok tovabbi előnye, hogy a halaszati intenzitas jol definialhato. Ennek megfelelően a kopoltyuhalo lett szamos nemzetkozi biomonitoring program elfogadott eszkoze (Appelberg es mtsai. 1995, Thoresson 1993). a kulonboző szembősegű egyedi halok alkalmazasaval szemben ma mar az ugynevezett tobbpaneles kopoltyuhalok alkalmazasa kerult előterbe egyszerűbb alkalmazhatosaguk es jobb osszegzett hatasfokuk miatt (Kurkilahti es Rask 1996). Az MTA Balatoni Limnologiai Kutatointezeteben a tobbpaneles kopoltyuhalok alkalmazasat 1996-ban kezdtuk el (Kirjasniemi es mtsai. 1997, Specziar es mtsai. 1996, 1997) es azota rendszeresen vegeztunk segitsegukkel halallomany vizsgalatokat (pl. Specziar es Tolg 2000, Specziar es mtsai. 2000, Tolg es mtsai. 1998) es szamos okologiai vizsgalathoz gyűjteseket. A kopoltyuhalos fogasokat szamos tenyező befolyasolja. Ezek kozul legfontosabbak a halallomany sűrűsege es osszetetele, a halo meret-szelektivitasa (a halo szembősege, rugalmassaga, erőssege), a halo „lathatosaga” (a haloanyag fenytoresenek elterese a vizetől, a viz zavarossaga) es a halak mozgekonysaga (osszefoglalo: Hubert 1996). Az eredmenyek reprodukalhatosagat leginkabb a viz zavarossaganak (Hansson es Rudstam 1995) es a halak mozgasi aktivitasanak valtozasai nehezitik meg. A halak mozgasi aktivitasa mind napszakosan, mind evszakosan fajonkent elterő modon valtozik. Ennek megfelelően a mintavetel időpontjatol fuggően mas lesz az egysegnyi időre juto fogas (CPUE), illetve a fajosszetetel, azonos egyeb feltetelek mellett is (Bourke es mtsai. 1996, Ericksen es Marshall 1997, Fujimori es mtsai. 1994, Neuman es mtsai. 1996). A halak mozgasara es elhelyezkedesere az időjarasnak es a vizjarasnak is jelentős hatasa van (pl. Begout-anras es Lagardere 1998). Jelen munkankban bemutatjuk a CPUE es a fogasok osszetetelenek napszakos es evszakos valtozasait a Balatonban, illetve targyaljuk az egyes halfajok mozgasi aktivitas ritmusanak valoszinű szerepet a fogasok alakulasaban.
Integrated lipidomic and transcriptomic analysis reveals diacylglycerol accumulation in olive of Longnan (China)

Background Olive (Olea europaea L.) oil accumulate more diacylglycerols (DAG) than mostly vegetable oils. Unsaturated fatty acids-enriched DAG consumption enhanced wellness in subjects. However, the mechanism of DAG accumulation is not yet fully understood. Methods In this study, gene network of DAG accumulation and fatty acid composition in the two olive mesocarps (“Chenggu 32” (CG) and “Koroneiki” (QJ)) were investigated by integrating lipidome and transcriptome techniques. Results A total of 1,408 lipid molecules were identified by lipidomic analysis in olive mesocarp, of which DAG (DAG36:3, DAG36:4 and DAG36:5) showed higher content, and triacylglycerols (TAG54:3, TAG54:4) exhibited opposite trend in CG. Specifically, DAG was rich in polyunsaturated fatty acids (especially C18:2) at the sn-2 position, which was inconsistent with TAG at the same positions (Primarily C18:1). Transcriptomic analysis revealed that phospholipase C (NPC, EC 3.1.4.3) were up-regulated relative to QJ, whereas diacylglycerol kinase (ATP) (DGK, EC 2.7.1.107), diacylglycerol acyltransferase (DGAT, EC 2.3.1.20), and phospholipid: diacylglycerol acyltransferase (PDAT, EC 2.3.1.158) were down-regulated. Conclusion We speculated that the non-acyl coenzyme A pathway played a significant role in DAG biosynthesis. Additionally, fatty acyl-ACP thioesterase B (FATB, EC 3.1.2.14), stearoyl [acyl-carrier-protein] 9-desaturase (SAD, EC 1.14.19.2) and omega-6 fatty acid desaturase (FAD2, EC 1.14.19.6) were highly expressed in CG and may be involved in regulating fatty acid composition. Meanwhile, phospholipase A1 (LCAT, EC 3.1.1.32) involved in the acyl editing reaction facilitated PUFA linkage at the sn-2 position of DAG. Our findings provide novel insights to increase the DAG content, improve the fatty acid composition of olive oil, and identify candidate genes for the production of DAG-rich oils.
Electrical and seismic anisotropy of the lithosphere with the focus on central southern Africa

The aim of this study was to gain a better geological understanding of the southern African region through the use of magnetotelluric (MT) and seismic techniques. Specifically, the newly collected southern African magnetotelluric experiment (SAMTEX) data are analysed for directionality using a tensor decomposition technique. Instead of conducting the analysis for given periods, as is commonly done, the data are analysed for approximate depths due to the variable electromagnetic penetration across the region. I also re-analyse previously collected southern African seismic experiment (SASE) data for shear wave splitting of teleseismic events using standard processing techniques. These analyses provide information on the electrical and seismic anisotropy properties of the region, which may then be related to tectonics and geological structure. It is found that MT conductive direction results, for both crustal and lithospheric mantle depths, are significantly more complex than has previously been observed in other regions. The complexity is attributed to be due to strong effects of large-scale conductivity heterogeneities on the conductive directions measured. The reanalysis of some of the SASE stations for shear wave splitting has produced near-identical results to those previously measured, and I was not able to conclusively demonstrate the presence or absence of 2-layer anisotropy. A previously unnoticed relationship is observed between thick lithosphere, and regions of well correlated seismic fast axis directions and plate motion directions. Combined with the observations of vertical variations in conductive directions of the MT results, this has led to a new model being proposed to explain the anisotropy results observed in the region. The model suggests both lithospheric and asthenospheric contributions to seismic anisotropy, with a significantly stronger anisotropic layer below thicker lithosphere, which is proposed to be due to stronger lattice preferred orientation (LPO) of olivine as a result of increased flow velocity below the thicker lithospheric keel. This model is supported by other geoscientific observations, including the results from the lithospheric and asthenospheric MT analysis. No strong correlation between the measured MT and seismic anisotropy parameters is observed, likely because the electrical anisotropy is strongly effected by structure, and the seismic anisotropy is predominantly a result of LPO of olivine (in places, quite strongly vertically varying).
Celecoxib in arthritis: relative risk management profile and implications for patients

: Celecoxib is a selective cyclo-oxygenase 2 inhibitor licensed for use in musculoskeletal symptoms as well as in primary dysmenorrhea and acute pain. One advantage celecoxib has over traditional nonsteroidal anti-inflammatory drugs is that of significantly fewer gastrointestinal side-effects associated with its use. Much has been published on the potential cardiovascular and cerebrovascular complications of its administration. This review details the available evidence to allow prescribers to make informed decisions in the light of potentially conflicting evidence. The overall cardiovascular risk is increased with higher doses of celecoxib but is comparable with nonselective nonsteroidal anti-inflammatory use. As with all of these drugs, the potential cardiovascular and gastrointestinal risks of prescription need to be weighed up against possible benefits for each individual patient and discussed with the patients themselves.
continuation of bevacizumab and addition of hormone therapy following weekly paclitaxel therapy in her2-negative metastatic breast cancer

Background: Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combination in a real-world setting. Patients and methods: Eligible patients received bevacizumab (10 mg/kg days 1 and 15, every 28 days) plus paclitaxel (80 mg/m 2 days 1, 8, and 15, every 28 days) as first-line therapy for MBC, or as subsequent lines, including bevacizumab continuation therapy, at La Paz University Hospital between August 2007 and October 2012. End points included objective response rate (ORR), PFS, overall survival (OS), and safety. Results: Seventy-eight patients were included. Median PFS was 12.8 months for patients receiving first-line treatment and 9.3 months for subsequent lines. Forty-five patients (57.7%) continued bevacizumab after stopping paclitaxel, and had significantly longer PFS and OS than those who did not (hazard ratio [HR] 0.40, 95% confidence interval [CI] 0.248–0.653, P , 0.001; HR 0.39, 95% CI 0.218–0.710, P = 0.002; respectively). In the continuation phase, estrogen receptor-positive patients had longer PFS and OS when receiving hormone therapy plus bevacizumab versus patients receiving only bevacizumab (HR 0.50, 95% CI 0.24–1.04, P = 0.06; HR 0.43, 95% CI 0.16–1.16, P = 0.09; respectively). Thirty-five patients (44.9%) reported grade 3–4 adverse events. Conclusion: Bevacizumab plus paclitaxel was effective in HER2-negative MBC. Continuation of bevacizumab and addition of hormone therapy following paclitaxel therapy could be beneficial.