Miracle-dz/UniFAR-FTUs huggingface dataset:
Homelessness and rates of physical dysfunctions characteristic of premature geriatric syndromes: systematic review and meta-analysis

ABSTRACT Background Homeless adults may experience accelerated aging, presenting earlier with geriatric syndromes such as falls and functional limitations. Though homelessness is surging in United States, data are scarce regarding rates of physical dysfunctions characteristic of geriatric syndromes experienced in this underserved population. Purpose Examine associations between homelessness, premature geriatric syndromes, and functional limitations. Methods Two reviewers independently searched PubMed, CINAHL, and PEDro databases for prognostic studies reporting rates of geriatric syndromes in homeless adults aged 40 years and older. Two reviewers independently performed study selection. Data were extracted for homeless adults and community-dwelling controls regarding age, demographic information, limitations of activities of daily living (ADL) and instrumental ADL (IADL), frailty, and falls the past year. Risk ratio (RR) and 95% confidence interval (CI) were calculated across studies to compare groups. Results Five studies met predetermined criteria. Meta-analysis revealed greater rates in homeless adults (average age 56) compared to housed adults (average age 78) for ADL limitation (RR = 1.50, 95% CI = 1.37–1.64) and IADL limitation (RR = 1.36, 95% CI = 1.28–1.45). Falls were three times more prevalent in homeless individuals (RR = 3.42, 95% CI = 3.16–3.70). Heterogeneous frailty data did not reach significance (RR = 2.59, 95% CI = 0.90–7.46). Conclusion Homeless adults have increased risk of premature geriatric syndromes. Limitations in ADL and IADL rates were 30–50% higher than adults with stable housing averaging 20 years older, and fall rates were three times higher than controls averaging 4.5 years older. These results underscore the need for healthcare providers such as physical therapists to address physical dysfunction in homeless adults.
Pneumothorax after CT-guided transthoracic lung biopsy: A comparison between immediate and delayed occurrence

Background In CT-guided transthoracic lung biopsy (CTLB), pneumothorax can occur as a late complication (delayed pneumothorax). The incidence, risk factors, and clinical significance of delayed pneumothorax are not well known. Objectives To compare the risk factors for immediate and delayed pneumothorax after CTLB and to know their clinical significance. Methods Images and medical records of 536 consecutive patients who underwent CTLB were reviewed. All biopsies were performed as inpatient procedures. Follow-up chest radiographs were obtained at least twice at 4 h after procedure and before discharge. Risk factors for immediate and delayed pneumothorax were assessed based on patient-, lesion-, and procedure-related variables. Rates of chest tube insertion were also compared. Results Pneumothorax developed in 161 patients (30.0%) including 135 (25.2%) immediate and 26 (4.9%) delayed cases. Lesion size was an independent risk factor for both immediate and delayed pneumothorax (OR = 0.813; CI = 0.717–0.922 and OR = 0.610; CI = 0.441–0.844, respectively). While emphysema, lower lobe location, and long intrapulmonary biopsy track were risk factors (OR = 1.981; CI = 1.172–3.344, OR = 3.505; CI = 2.718–5.650, and OR = 1.330; CI = 1.132–1.563, respectively) for immediate pneumothorax, upper lobe location and increased number of pleural punctures were independent risk factors (OR = 5.756; CI = 1.634–20.274 and OR = 3.738; CI = 1.860–7.511, respectively) for delayed pneumothorax. The rate of chest tube insertion was significantly (p < 0.001) higher in delayed pneumothorax. Conclusion Pneumothorax tends to occur immediately after CTLB in patients with emphysema, lower lobe lesion, and long intrapulmonary biopsy track. Further attention and warnings are needed for those with multiple punctures of small lesions involving upper lobes due to the possibility of delayed development of pneumothorax and higher requirement for chest tube drainage.
How Much Does Ne Vary Among Species?

The population frequency of polymorphic alleles varies in time. This variation has a stochastic component, mainly determined by the size of the considered population, Ne: genetic drift. Genetic drift is an important evolutionary force of strength inversely proportional to Ne, the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power among species of animals via its effect on the mutation load – which implies also inferring the distribution of fitness effects of deleterious mutations. To this aim, we analyze the nonsynonymous (amino-acid changing) and synonymous (amino-acid conservative) allele frequency spectra in a large sample of metazoan species, with a focus on the primates vs. fruit flies contrast. We show that a Gamma model of the distribution of fitness effects is not suitable due to strong differences in estimated shape parameters among taxa, while adding a class of lethal mutations essentially solves the problem. Using the Gamma + lethal model and assuming that the mean deleterious effects of nonsynonymous mutations is shared among species, we estimate that the power of drift varies by a factor of at least 500 between large-Ne and small-Ne species of animals, i.e., an order of magnitude more than the among-species variation in genetic diversity. Our results are relevant to Lewontin’s paradox while further questioning the meaning of the Ne parameter in population genomics.
A single exposure to eucalyptus smoke sensitizes rats to the postprandial cardiovascular effects of a high carbohydrate oral load

Abstract Objective Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict cardiovascular risk, in assessing the impacts of exposure to eucalyptus smoke (ES), a contributor to wildland fire air pollution in the Western coast of the United States. Materials and methods Three-month-old male Sprague Dawley rats were exposed once (1 h) to filtered air (FA) or ES (700 µg/m3 fine particulate matter), generated by burning eucalyptus in a tube furnace. Rats were then fasted for six hours the following morning, and subsequently administered an oral gavage of either water or a HC suspension (70 kcal% from carbohydrate), mimicking a HC meal. Two hours post gavage, cardiovascular ultrasound, cardiac pressure–volume (PV), and baroreceptor sensitivity assessments were made, and pulmonary and systemic markers assessed. Results ES inhalation alone increased serum interleukin (IL)-4 and nasal airway levels of gamma glutamyl transferase. HC gavage alone increased blood glucose, blood pressure, and serum IL-6 and IL-13 compared to water vehicle. By contrast, only ES-exposed and HC-challenged animals had increased PV loop measures of cardiac output, ejection fraction %, dP/dt max, dP/dt min, and stroke work compared to ES exposure alone and/or HC challenge alone. Discussion and conclusions Exposure to a model wildfire air pollution source modifies cardiovascular responses to HC challenge, suggesting air pollution sensitizes the body to systemic triggers.
The Estimation of Surface Albedo from DSCOVR EPIC

Surface albedo is an important parameter in climate models. The main way to obtain continuous surface albedo for large areas is satellite remote sensing. However, the existing albedo products rarely meet daily-scale requirements, which has a large impact on climate change research and rapid dynamic changes of surface analysis. The Earth Polychromatic Imaging Camera (EPIC) on the Deep Space Climate Observatory (DSCOVR) platform, which was launched into the Sun–Earth’s first Lagrange Point (L1) orbit, can provide spectral images of the entire sunlit face of Earth with 10 narrow channels (from 317 to 780 nm). As EPIC can provide high-temporal resolution data, it is beneficial to explore the feasibility of EPIC to estimate high-temporal resolution surface albedo. In this study, hourly surface albedo was calculated based on EPIC observation data. Then, the estimated albedo results were validated by ground-based observations of different land cover types. The results show that the EPIC albedo is basically consistent with the trend of the ground-based observations in the whole time series variation. The diurnal variation of the surface albedo from the hourly EPIC albedo exhibits a “U” shape curve, which has the same trend as the ground-based observations. Therefore, EPIC is helpful to enhance the temporal resolution of surface albedo to diurnal. Surfaces with a three-dimensional structure that casts shadows display the hotspot effect, producing a reflectance peak in the retro-solar direction and lower reflectance at viewing angles away from the solar direction. DSCOVR observes the entire sunlit face of the Earth, which is helpful to make up for the deficiency in the observations of traditional satellites in the hotspot direction in bidirectional reflectance distribution function (BRDF) research, and can help to improve the underestimation of albedo in the direction of hotspot observation.
Modification of fecal microbiota as a mediator of effective weight loss and metabolic benefits following bariatric surgery

ABSTRACT Introduction Bariatric surgery (primarily Laparoscopic Sleeve Gastrectomy [LSG] and Roux-en-Y Gastric Bypass [RYGB]) is an efficacious and durable therapeutic option for weight loss in obesity. The mechanisms that mediate weight loss following bariatric surgery remain incompletely understood. Areas covered Pubmed search of published data on fecal microbiota, metabolic health, LSG, and RYGB. The fecal microbiome plays a key role in the establishment and maintenance of metabolic wellbeing, and may also contribute (through fecal dysbiosis) to metabolic dysfunction. LSG and RYGB both result in characteristic, procedure-specific changes to the fecal microbiota that may mediate at least some of the resultant weight-loss and metabolically beneficial effects, when applied to the management of obesity. Expert opinion The human fecal microbiome, containing around 100 trillion microbes, evolved over millions of years and interacts symbiotically with its human host. Rodent-based studies have provided insights into the complexities of the gut-microbiome-brain axis. This includes the important role of the gut microbiome in the mediation of normal immunological development, inflammatory pathways, metabolic functioning, hypothalamic appetite regulation, and the absorption of essential nutrients as by-products of bacterial metabolism. Fecal transformation is likely to provide an important therapeutic target for future prevention and management of obesity and metabolic dysfunction.
Gut microbiome adaptation to extreme cold winter in wild plateau pika (Ochotona curzoniae) on the Qinghai-Tibet Plateau.

The Qinghai-Tibet Plateau (QTP) is harsh environment characterized by low temperature, high altitude and hypoxia, while some native mammals may well adapt to the extreme climate. However, how animal gut microbial community structure and function adapt to extreme cold climate is not well understood. Plateau pika (Ochotona curzoniae) is an ideal animal model to study the effects of climate change on host adaptation by studing intestinal microorganisms. Here, we used 16S rRNA sequencing technology combined with physiological methods to investigate plateau pika gut microbiota in summer and winter. Due to limited diet resource, the pikas in winter had a lower ability of degradation and fermentation for plant-based food (reduced cellulase activity and total short-chain fatty acids) by decreasing gut microbial diversity and some functional microbes, such as fiber-degrading bacteria Oscillospira and Treponema. Metagenomic prediction showed that most of those gene functions associated with metabolism (e.g. energy metabolism and lipid metabolism) were less abundant in winter, implying that the plateau pika slows diet fermentation and weakens energy requirements in the cold season. Our results have important significance for explaining the mechanism of wild plateau mammals adapting to high-altitude cold environment from the perspectives of gut microbiome.
Food Consumption by Lymantria dispar (Lepidoptera: Lymantriidae) Larvae Infected with Entomophaga maimaiga (Zygomycetes: Entomophthorales)

Food consumption by healthy fifth-instar gypsy moths, Lymantria dispar , and larvae infected with Entomophaga maimaiga was compared. Infected larvae ate less food than healthy larvae during the two days before death. Weight gain of infected larvae was less than weight gain of healthy larvae from 3 d after inoculation. Although death of infected larvae was hastened by starvation, E. maimaiga was able to develop successfully in larvae that received no food after infection, suggesting that larval feeding during the associated period of incubation is not necessary for fungal development.
3D Versus 4K Display System – Influence of “State-of-the-art”-Display Technique on Surgical Performance (IDOSP-study) in Minimally Invasive Surgery

Objective: To evaluate if “state-of-the-art” 3D- versus 4K-display techniques could influence surgical performance. Background: High quality minimally invasive surgery is challenging. Therefore excellent vision is crucial. 3D display technique (3D) and 2D-4K technique (4K) are designed to facilitate surgical performance, either due to spatial resolution (3D) or due to very high resolution (4K). Methods: In randomized cross-over trial the surgical performance of medical students (MS), non-board certified surgeons (NBC), and board certified surgeons (BC) was compared using 3D versus 4K display technique at a minimally invasive training Parkour. Results: One hundred twenty-eight participants were included (February 2018 through October 2019, 49 MS, 39 NBC, 40 BC). The overall Parkour time (s) 3D versus 4K was 712.5 s ± 17.5 s versus 999.5 s ± 25.1 s (P < 0.001) for all levels of experience. It was (3D vs 4K) for MS (30 tasks) 555.4 s ± 28.9 s versus 858.7 s ± 41.6 s, (P < 0.0001), for NBC (42 tasks) 935.9 s ± 31.5 s versus 1274.1 s ± 45.1 s (P =< 0.001) and for BC (42 task) 646.3 s ± 30.9 s versus 865.7 s ± 43.7 s (P < 0.001). The overall number of mistakes was (3D vs 4K) 10.0 ± 0.5 versus 13.3 ± 0.7 (P < 0.001), for MS 8.9 ± 0.9 versus 13.1 ± 1.1 (P < 0.001), for NBC 12.45 ± 1.0 versus 16.7 ± 1.2 (P < 0.001) and for BC 8.8 ± 1.0 versus 10.0 ± 1.2 (P = 0.18). MS, BC, and NBC showed shorter performance time in 100% of the task with 3D (significantly in 6/7 tasks). For number of mistakes the effect was less pronounced for more experienced surgeons. The National Aeronautics and Space Administration-task load index was lower with 3D. Conclusion: 3D laparoscopic display technique optimizes surgical performance compared to the 4K technique. Surgeons benefit from the improved visualization regardless of their individual surgical expertise.
Chain Length Diversity of Sialic Acids and Its Biological Significance

糖鎖末端には通常1残基のシアル酸が存在するが、そのシアル酸残基の上にさらに数残基のシアル酸が直鎖状に縮重合してシアル酸重合体を形成する場合がある。 α2→8結合ジシアル酸 (重合度DP=2) 構造はガングリオシドの構成成分としてよく知られており、細胞接着、細胞分化、シグナル伝達、時期特異的発現など、多くの生物学的機能を果たしている。 また重合度が8以上のポリシアル酸構造は神経細胞接着分子上に存在しており、発生や分化に関わることが知られている。 しかし、重合度が2から7程度のジ・オリゴシアル酸構造をもつ糖タンパク質の存在や機能についてはこれまでほとんど注目されて来なかった。 しかし近年、ジ・オリゴ・ポリシアル酸 (シアル酸重合体) 構造を微量検出する手法が改良され、天然にジ・オリゴ・ポリシアル酸含有糖タンパク質がこれまで知られている以上に数多く存在することが明らかにされてきている。 そのため糖タンパク質上のシアル酸重合体構造が、既にガングリオシドにおいて明らかにされてきた機能の一端を担う可能性が、また従来考えられてきたこととは全く異なる新たな機能を担っていること、さらには新たなポリシアル酸の機能が明らかになってくるかもしれない。 この総説ではシアル酸重合体の分析法、生合成、存在、機能における最近の知見を述べる。
Long-term Oncologic Results After Stenting as a Bridge to Surgery Versus Emergency Surgery for Malignant Left-sided Colonic Obstruction: A Multicenter Randomized Controlled Trial (ESCO Trial).

OBJECTIVE To assess overall (OS), time to progression (TTP), and disease-free survival (DFS) at 3 years after treatment, comparing stenting as bridge-to-surgery (SBTS) versus emergency surgery (ES) in neoplastic left colon obstruction, secondary endpoints of the previously published randomized controlled trial. BACKGROUND While SBTS in neoplastic colon obstruction may reduce morbidity and need for a stoma compared with ES, concern has been raised, about long-term survival. METHODS Individuals affected by left-sided malignant large-bowel obstruction were enrolled from 5 European hospitals and randomly assigned (1:1 ratio) to receive SBTS or ES. The computer-generated randomization sequence was stratified by center on cT and concealed by the use of a web-based application. Investigators and participants were unmasked to treatment assignment. The secondary outcomes analyzed here were OS, TTP, and DFS. Analysis was by intention to treat. This study is registered, ID-code NCT00591695. RESULTS Between March 2008 and November 2015, 144 patients were randomly assigned to undergo either SBTS or ES; 115 (SBTS n = 56, ES n = 59) were eligible for analysis, while 20 participants were excluded for a benign disease, 1 for unavailability of the endoscopist while 8 withdrew from the trial. With a median follow-up of 37 months (range 1-62), no difference was observed in the SBTS group compared with ES in terms of OS (HR 0.93 (95% CI 0.49-1.76), P = 0.822), TTP (HR 0.81 (95% CI 0.42-1.54), P = 0.512), and DFS (HR 1.01 (95% CI 0.56-1.81), P = 0.972). Planned subgroup analysis showed no difference in respect to age, sex, American Society for Anesthesiology score, body mass index, and pT between SBTS and ES groups. Those participants randomized for the SBTS group whose obstruction was located in the descending colon had a better TTP compared with ES group (HR 0.44 (95% CI 0.20-0.97), P = 0.042), but no difference was observed in terms of OS (HR 0.73 (95% CI 0.33-1.63), P = 0.442) and DFS (HR 0.68 (95% CI 0.34-1.34), P = 0.261) in the same individuals. CONCLUSIONS This randomized controlled trial shows that, although not powered for these seconday outcomes, OS, TTP, and DFS did not differ between groups at a minimum follow-up of 36 months.
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli.

Aim: To investigate the action mechanism of 1-benzyl-1,4-diazepane (1-BD) as efflux pump inhibitor (EPI) in Escherichia coli mutants: ΔacrAB or overexpressing AcrAB and AcrEF efflux pumps. Materials & methods: Effect of 1-BD on: antibiotic potentiation, by microdilution method; membrane functionality, by fluorimetric assays; ethidium bromide accumulation, by fluorometric real-time efflux assay; AcrB expression, by quantitative photoactivated localization microscopy. Results: 1-BD decreases the minimal inhibitory concentration of levofloxacin and other antibiotics and increase ethidium bromide accumulation in E. coli overexpressing efflux pumps but not in the ΔacrAB strain. 1-BD increases membranes permeability, without sensibly affecting inner membrane polarity and decreases acrAB transcription. Conclusion: 1-BD acts as an EPI in E. coli with a mixed mechanism, different from that of major reference EPIs.
The EEG Signal Analysis for Spatial Cognitive Ability Evaluation Based on Multivariate Permutation Conditional Mutual Information-Multi-Spectral Image

This study aims to find an effective method to evaluate the efficacy of cognitive training of spatial memory under a virtual reality environment, by classifying the EEG signals of subjects in the early and late stages of spatial cognitive training. This study proposes a new EEG signal analysis method based on Multivariate Permutation Conditional Mutual Information-Multi-Spectral Image (MPCMIMSI). This method mainly considers the relationship between the coupled features of EEG signals in different channel pairs and transforms the multivariate permutation conditional mutual information features into multi-spectral images. Then, a convolutional neural networks (CNN) model classifies the resultant image data into different stages of cognitive training to objectively assess the efficacy of the training. Compared to the multi-spectral image transformation method based on Granger causality analysis (GCA) and permutation conditional mutual information (PCMI), the MPCMIMSI led to better classification performance, which can be as high as 95% accuracy. More specifically, the Theta-Beta2-Gamma-band combination has the best accuracy. The proposed MPCMIMSI method outperforms the multi-spectral image transformation methods based on GCA and PCMI in terms of classification performance. The MPCMIMSI feature in the Theta-Beta2-Gamma band is an effective biomarker for assessing the efficacy of spatial memory training. The proposed EEG feature-extraction method based on MPCMIMSI offers a new window to characterize spatial information of the noninvasive EEG recordings and might apply to assessing other brain functions.
Neurophysiological correlates of abnormal auditory processing in episodic migraine during the interictal period

Background The characteristics of the hypersensitivity to auditory stimuli during the interictal period in episodic migraine are discussed. The combined use of event-related potentials, time-frequency power and phase-synchronization can provide relevant information about the time-course of sensory-attentional processing in migraine and its underlying mechanisms. Objective The aim of this nested case-control study was to examine these processes in young, female, episodic migraine patients interictally and compare them to controls using an active auditory oddball task. Method We recorded, using 20 channels, the electrophysiological brain activity of 21 women with episodic migraine without aura and 21 healthy matched controls without family history of migraine, during a novelty oddball paradigm. We collected sociodemographic and clinical data as well as scores related to disability, quality of life, anxiety and depression. We calculated behavioural measures including reaction times, hit rates and false alarms. Spectral power and phase-synchronization of oscillatory activity as well as event-related potentials were obtained for standard stimuli. For target and novel stimuli, event-related potentials were acquired. Results There were no significant differences at the behavioural level. In migraine patients, we found an increased phase-synchronization at the theta frequency range and a higher N1 response to standard trials. No differences were observed in spectral power. No evidence for a lack of habituation in any of the measures was seen between migraine patients and controls. The Reorienting Negativity was reduced in migraine patients as compared to controls on novel but not on target trials. Conclusion Our findings suggest that migraine patients process stimuli as more salient, seem to allocate more of their attentional resources to their surrounding environment, and have less available resources to reorient attention back to the main task.