Miracle-dz/UniFAR-FTUs huggingface dataset:
Cellsin Human Peripheral Blood Mononuclear T Cell Function and Activates Lymphocytes Regulatory + Targeting of TLRs Inhibits CD4

Accumulating evidence suggests elements within tumors induce exhaustion of effector T cells and inﬁltration of immunosuppressive regulatory T cells (Tregs), thus preventing the development of durable antitumor immunity. Therefore, the discovery of agents that simultaneously block Treg suppressive function and reinvigorate effector function of lymphocytes is key to the development of effective cancer immunotherapy. Previous studies have shown that TLR ligands (TLRLs) could modulate the function of these T cell targets; however, those studies relied on cell-free or accessory cell-based assay systems that do not accurately reﬂect in vivo responses. In contrast, we used a human PBMC-based proliferation assay system to simultaneously monitor the effect of TLRLs on T cells (CD4 + , CD8 + , Tregs), B cells, and NK cells, which gave different and even conﬂicting results. We found that the TLR7/ 8L:CL097 could simultaneously activate CD8 + T cells, B cells, and NK cells plus block Treg suppression of T cells and B cells. The TLRLs TLR1/2L:Pam 3 CSK4, TLR5L:ﬂagellin, TLR4L:LPS, and TLR8/7L:CL075 also blocked Treg suppression of CD4 + or CD8 + T cell proliferation, but not B cell proliferation. Besides CL097, TLR2L:PGN, CL075, and TLR9L:CpG-A, CpG-B, and CpG-C) were strong activators of NK cells. Importantly, we found that Pam 3 CSK4 could: 1) activate CD4 + T cell proliferation, 2) inhibit the expansion of IL-10 + naturally occurring FOXP3 + Tregs and induction of IL-10 + CD4 + Tregs (IL-10–producing FOXP3 Tregs suppressive Our results suggest adjuvants to enhance the efﬁcacy of current immunotherapeutic strategies in cancer patients.
and predictions for key

Despite the great interest in oxygenated methyl ethers as diesel fuel additives and as fuels themselves, the inﬂuence of their methylenedioxy group(s) (O − CH 2 − O) has never been quantiﬁed using ab initio methods. In this study we elucidate the kinetics and thermochemistry of dimethoxymethane using high-level ab initio (CCSD(T)/aug-cc-pV(D+T)Z//B2PLYPD3BJ/6-311++g(d,p)) and statistical mechanics methods. We model torsional modes as hindered rotors which has a large inﬂuence on the description of the thermal behavior. Rate constants for hydrogen abstraction by . H and . CH 3 are computed and show that abstraction from the methylenedioxy group is favored over abstraction from the terminal methyl groups. β Scission and isomerization of the radicals is computed using master equations. The eﬀect of rovibrationally excited radicals from preceding hydrogen abstraction reactions on subsequent hot β -scission is computed and has large inﬂuence on the decomposition of the formed dimethylether radical. In the second part of this study, the computed kinetics and thermochemistry is used in a detailed model. The quantiﬁcation of the eﬀect of the dominant methylenedioxy group using ab initio methods can guide modeling of oxygenated methyl ethers that contain that group several times.
Food Neophobia among Brazilian Children: Prevalence and Questionnaire Score Development

: This study aims to create and validate a score to classify food neophobia among Brazilian children (from the ages of 4 to 11 years) and investigate the prevalence of food neophobia. This descriptive cross-sectional population-based study is conducted following three steps: (i) the application of an instrument to identify food neophobia in Brazilian children by their caregivers; (ii) the instrument’s score deﬁnition; and (iii) the evaluation and characterization of the national prevalence of food neophobia among Brazilian children. The scores were categorized into three levels, based on the tertial approximation: low, moderate, and high. The study had 1112 participants, and the prevalence of high food neophobia was observed in 33.4% of Brazilian children. The prevalence of food neophobia allowed us to identify this behavior in Brazilian children and better understand the population. Boys were signiﬁcantly more neophobic than girls. The general neophobia score and domains did not signiﬁcantly differ between Brazilian regions and age groups. It is worrying that food neophobia did not decrease with advancing age. The score for the complete instrument with 25 items, or the 3 domains, makes its use practical. It can be used to assess neophobia with more caution, evaluate the most neophobic children, and enable more targeted professional interventions to promote healthier and sustainable eating habits.
EXPLORATORY SEARCH USING VECTOR MODEL AND LINKED DATA

The way people acquire knowledge has largely shifted from print to web resources. Meanwhile, search has become the main medium to access information. Amongst various search behaviors, exploratory search represents a learning process that involves complex cognitive activities and knowledge acquisition. Research on exploratory search studies on how to make search systems help people seek information and develop intellectual skills. This research focuses on information retrieval and aims to build an exploratory search system that shows higher clustering performance and diversified search results. In this study, a new language model that integrates the state-of-the-art vector language model (i.e., BERT) with human knowledge is built to better understand and organize search results. The clustering performance of the new model (i.e., RDF+BERT) was similar to the original model but slight improvement was observed with conversational texts compared to the pre-trained language model and an exploratory search baseline. With the addition of the enrichment phase of expanding search results to related documents, the novel system also can display more diverse search results.
Optimization of the Growth Process of Double Perovskite Pr2−δNi1−xMn1+xO6−y Epitaxial Thin Films by RF Sputtering

Epitaxial thin films of Pr2−δNi1−xMn1+xO6−y (PNMO) double perovskite were grown on (001)-oriented SrTiO3 substrates by RF magnetron sputtering. The influence of the growth parameters (oxygen pressure, substrate temperature, and annealing treatments) on the structural, magnetic and transport properties, and stoichiometry of the films was thoroughly investigated. It is found that high-quality epitaxial, insulating, and ferromagnetic PNMO thin films can only be obtained in a narrow deposition parameter window. It is shown that a careful selection of the growth conditions allows for obtaining a high degree of Ni/Mn cation ordering, which is reflected in the values of the Curie temperature, TC, and saturation magnetization, MS, which are very close to those of bulk material.
Results of WFC3 Thermal Vacuum Testing: UVIS Readnoise and Dark Current

The dark current and readout noise levels for WFC3’s UVIS channel were tested during thermal vacuum testing in September and October, 2004. Measured readnoise values were comparable to those measured during mini-ambient testing (Baggett, 2004 and Hilbert et al., 2004), below the CEI specification of 4 e - , and just above the goal of 3 e - . Measured RMS dark currents were 0.16 - 0.5 e - /pix/hour, lower than those from mini-ambient testing, and well below the CEI specification of 20 e - /pix/hour.
Optical turbulence forecast over short timescales using machine learning techniques

Forecast of optical turbulence and atmospheric parameters relevant for ground-based astronomy is becoming an important goal for telescope planning and AO instruments optimization in several major telescope. Such detailed and accurate forecast is typically performed with numerical atmospheric models. Recently short-term forecasts (a few hours in advance) are also being provided (ALTA project) using a technique based on an autoregression approach, as part of a strategy that aims to increase the forecast accuracy. It has been proved that such a technique is able to achieve unprecedented performances so far. Such short-term predictions make use of the numerical model forecast and real-time observations. In recent years machine learning (ML) techniques also started to be used to provide an atmospheric and turbulence forecast. Preliminary results indicate however an accuracy not really competitive with respect to the autoregressive method or even prediction by persistence. This technique might be applicable joint to atmospheric model. It is therefore interesting to investigate the main features of their performances and characteristics (also because there is a great number of algorithms potentially accessible) to understand if results achieved so far can be further improved using ML. In this study we focus on a purely machine learning application to short term forecast (1-2 hours) of astroclimatic and other atmospheric parameters above VLT.
Proteomic analysis of tendons at different risk of injury.

Tendon injury is a common problem in both human and veterinary medicine, which impacts on the both the quality of life of the individual in question but also a financial implication on the supporting health system. Previous research into the pathogenesis of tendon injury and also the healing and treatment options available are limited. This one year project aimed to advance our knowledge in proteomics of human and equine tendons by developing proteomic methodologies for the analysis of the normal protein composition. In order to build a proteomic tendon library three different protein extraction protocols were considered, urea, guanidine and Rapigest. Results revealed urea had a poor extraction ability and that guanidine and Rapigest had a better success rate. Further work to combine these to agents would be worthwhile in the future. Further to this to this analysing spatial distribution of these proteins was then investigated in equine tissue. This work made some progress in optimizing a protocol, finding trypsin digestion worked better when incubated for 16 hours and also when the digestion occurred with an ammonium bicarbonate buffer. The fourth chapter investigated whether it is possible to detect in vivo changes in the proteomic composition of dialysis fluid subsequent to shockwave therapy of human Achilles tendon. This study revealed that current methods were sensitive enough to ascertain the protein composition but further work is needed to ascertain what significant protein changes occur in response to therapy. Finally tendon protein turnover was explored in an in-vivo model. Results confirmed proteins within the non collagenous matrix had a higher rate of protein turnover compared to components of the collagenous matrix. All four projects have been the first of their kind so optimisiation and a ‘look and see’ approach was required, which has laid foundations for several subsequent studies.
MACHINE-READING PLACES & SPACES Generative Probabilistic Modelling of Urban Thematic Zones & Contexts

In this paper, a "place" is conceptualised as a composition of dynamic socioeconomic activities and collective perceptions. We apply generative probabilistic modelling to explore urban contextual semantics. By analogy to sorting documents into different topics, this research retrieves data embedding for each urban regions and classify them with thematic zones. Using Singapore as a case study, topic modelling is applied to retrieve perceptual and functional thematic zones from Instagram and TripAdvisor respectively. A subsequent analysis shows strong correlations among certain regions with functional and perceptual consistency. In addition, with our proposed uniqueness and diversity indices, a strong negative correlation at 0.82 is found, suggesting that a region could be more unique if the functions tend to be dominated by certain types of functional and perceptual thematic zones.
Adsorptive Removal of Naproxen from Water Using Polyhedral Oligomeric Silesquioxane (POSS) Covalent Organic Frameworks (COFs)

Covalent organic frameworks are porous crystalline compounds made up of organic material bonded together by strong reversible covalent bonds (these are novel types of materials which have the processability of extended or repeated structures with high performance, like those of thermosets and thermoplastics that produce high surface coverage). These have a long-term effect on an arrangement’s geometry and permeability. These compounds are entirely made up of light elements like H, B, C, N, O and Si. Pharmaceuticals and personal care products (PPCPs) have emerged as a new threatened species. A hazardous substance known as an “emerging toxin,” such as naproxen, is one that has been established or is generated in sufficient amounts in an environment, creating permanent damage to organisms. COF-S7, OAPS and 2-methylanthraquionone(2-MeAQ), and COF-S12, OAPS and terephthalaldehyde (TPA) were effectively synthesized by condensation (solvothermal) via a Schiff base reaction (R1R2C=NR′), with a molar ratio of 1:8 for OAPS to linker (L1 and L2), at a temperature of 125 °C and 100 °C for COF-S7 and COF-S12, respectively. The compounds obtained were assessed using several spectroscopy techniques, which revealed azomethine C=N bonds, aromatic carbon environments via solid 13C and 29Si NMR, the morphological structure and porosity, and the thermostability of these materials. The remedied effluent was investigated, and a substantial execution was noted in the removal ability of the naproxen over synthesized materials, such as 70% and 86% at a contact time of 210 min and 270 min, respectively, at a constant dose of 0.05 g and pH 7. The maximum adsorption abilities of the substances were found to be 35 mg/g and 42 mg/g. The pH result implies that there is stable exclusion with a rise in pH to 9. At pH 9, the drop significance was attained for COF-S7 with the exception of COF-S12, which was detected at pH 11, due to the negative Foster charge, consequent to the repulsion among the synthesized COFs and naproxen solution. From the isotherms acquired (Langmuir and Freundlich), the substances displayed a higher value (close to 1) of correlation coefficient (R2), which showed that the substances fit into the Freundlich isotherm (heterogenous process), and the value of heterogeneity process (n) achieved (less than 1) specifies that the adsorption is a chemical process. Analysis of the as-prepared composites revealed remarkable reusability in the elimination of naproxen by adsorption. Due to its convenience of synthesis, significant adsorption effectiveness, and remarkable reusability, the as-synthesized COFs are expected to be able to be used as potential adsorbents for eliminating AIDs from water.
The strongest cool core in REXCESS: Missing X-ray cavities in RXC J2014.8-2430?

We present a multiwavelength study of RXC J2014.8-2430, the most extreme cool-core cluster in the Representative $XMM-Newton$ Cluster Structure Survey (REXCESS), using $Chandra$ X-ray, Southern Astrophysical Research (SOAR) Telescope, Atacama Large Millimeter/submillimeter Array (ALMA), Very Large Array (VLA), and Giant Metrewave Radio Telescope (GMRT) observations. While feedback from an active galactic nucleus (AGN) is thought to be the dominant mechanism by which a cooling flow is suppressed, the $Chandra$ imaging observations surprisingly do not reveal the bi-lateral X-ray cavities expected in the intracluster medium (ICM) of an extreme cool core hosting a powerful radio source. We discuss the limits on the presence of any radio bubbles associated with any undetected X-ray cavities. We place upper limits on any significant X-ray AGN in the brightest cluster galaxy, and show that the X-ray peak is offset from the central radio source, which exhibits a steep low frequency radio spectrum indicative of electron ageing. The SOAR data reveal an extended, luminous emission line source. From our narrowband H$\alpha$ imaging of the BCG, the central H$\alpha$ peak is coincident with the radio observations, yet offset from the X-ray peak, consistent with sloshing found previously in this cluster. ALMA observations reveal a large reservoir of molecular gas that traces the extended H$\alpha$ emission. We conclude either that the radio source and its cavities in the X-ray gas are nearly aligned along the line of sight, or that ram pressure induced by sloshing has significantly displaced the cool molecular gas feeding it, perhaps preempting the AGN feedback cycle. We argue that the sloshing near the core is likely subsonic, as expected, given the co-location of the H$\alpha$, CO(1-0), radio continuum, and stellar emission peaks and their proximity to the intact cool core seen in X-ray.
Soft Channel Estimation and Localization for Millimeter Wave Systems With Multiple Receivers

In millimeter wave (mmWave) communications, user position information can enable various position-based communication services, such as resource allocation, beam tracking and alignment, interference control, and synchronization. Classical localization methods focus on hard localization information, but soft localization provides the confidence levels in position estimates and thus enables the information to be efficiently fused with different measurements and application layers to realize integrated communication and localization. In this study, we propose a soft channel estimation and localization algorithm for an mmWave systems with multiple base stations. We present the Newtonized variational inference spectral estimation algorithm to extract soft information of position-related channel parameters. The soft localization algorithm estimates user position by using soft channel parameters from the expectation propagation simultaneous localization and mapping algorithm framework. The proposed algorithms realize channel estimation and localization in the communication process and refine the channel estimation through the localization information. Numerical results show that the proposed algorithms approach the Cramér-Rao lower bound for channel estimation and localization, and are thus verified to be effective.
When Occupational Self Efficacy and Intrinsic Motivation Influence on Job Satisfaction and Job Performance

This study aims to determine the effect of occupational self-efficacy on intrinsic motivation, job satisfaction and job performance. In addition, the influence of intrinsic motivation on job satisfaction and job performance. This research is a descriptive quantitative study made using the structural equational modeling (SEM) method. Data collection was used by distributing online questionnaires. The population of this study are employees of private companies in the areas of Jakarta, Bogor, Depok, Tangerang, and Bekasi (Jabodetabek). The sampling method used is purposive sampling with criteria that have worked for 2 years and over. The results of this study prove that there is a positive influence between occupational self-efficacy and intrinsic motivation, job satisfaction and job performance. Then it also proves that there is a positive influence between intrinsic motivation on job satisfaction but not on job performance.
Relative timing calibration of the Resolve x-ray microcalorimeter onboard XRISM using the modulated x-ray source

The Resolve instrument onboard the x-ray imaging and spectroscopy mission (XRISM) hosts an x-ray microcalorimeter that consists of 36 pixels in an array operated at 50 mK. It is currently under development and will be launched in 2022. x-ray microcalorimeters are known for their high spectral resolution, but they also excel in timing resolution for the necessity of cross-correlating event signals with templates in the time domain for accurate energy derivation. Primary and redundant modulated x-ray sources (MXS) are installed in Resolve for the purpose of correcting changes in the energy scale of the microcalorimeters while minimizing additional background; each source is switched on for intervals of O (1 ms) with a duty cycle of ∼1 %. The MXS can also be utilized for calibrating relative timing as a function of pixel, event grade, and energy. We had a week-long run in 2022 June using the flight model hardware during the spacecraft level test with several different settings. We describe the method and the result of the relative timing calibration using this dataset.
INFLUENCE OF PHYSICAL EXERCISE ON THE FUNCTIONAL CAPACITY IN INSTITUTIONALIZED ELDERLY

Introducao: Com o rapido aumento da expectativa de vida, os programas de exercicios fisicos sistematicos podem influenciar positivamente a capacidade funcional dos idosos, especialmente com relacao a institucionalizacao. Objetivo: Analisar a associacao entre um programa de exercicio fisico sistematico e a capacidade funcional em idosos institucionalizados. Metodos: A amostra incluiu 30 individuos idosos (16 mulheres e 14 homens) com idade de 60 anos ou mais (media de idade = 74,43), distribuidos em grupo controle (n = 16) e grupo treinamento (n = 14), residentes em uma instituicao de longa permanencia. Foi aplicado um protocolo de treinamento de 12 semanas, duas sessoes semanais, e a capacidade funcional foi avaliada antes e apos a intervencao, por meio de testes de levantar e sentar da cadeira (forca de membros inferiores), forca de membro superior, timed up and go e forca de preensao manual. A analise pre e pos-treinamento dos grupos intervencao e controle foi realizada com o teste t de Student pareado e o teste de ANOVA para medidas repetidas. O nivel de significância foi estabelecido em 5%. Resultados: A principal significância estatistica foi encontrada para os seguintes testes funcionais: forca do membro superior (treinamento 15,6 ± 4,1 x controle 10,7 ± 6,6 rep, p < 0,05) e levantar e sentar de uma cadeira (treinamento 11,0 ± 4,0 x controle 8,0 ± 3,1 rep, p < 0,05). Conclusao: O protocolo utilizado demonstrou ser eficaz na melhoria de algumas das capacidades funcionais dos idosos institucionalizados.
Neonatal feeding of an estrogen receptor β agonist induces external adenomyosis-like lesions in ICR mouse

Objective: Despite the fact that adenomyosis is a fairly common gynecological disorder, its pathogenesis remains elusive. Several theories on the pathogenesis of adenomyosis have been proposed, but none of them has been proven experimentally. So far, the most used one is the neonatal feeding of tamoxifen (TAM) in Institute of Cancer Research/cryopreserved (ICR/CD-1) mouse. However, its underlying mechanism of action is unknown. To further delineate the mechanism of TAM-induced adenomyosis in ICR/CD-1 mouse with regard to specific estrogen receptor (ER), we conducted an experiment that neonatal mice were fed with either TAM, or 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol (PPT; an ERα agonist), or 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN; an ERβ agonist), or G-1 (a G-protein coupled receptor 30 agonist), or just vehicle, in an attempt to tease out which specific receptor plays a dominant role in the genesis of adenomyosis induced by neonatal feeding of TAM. Methods: Forty female neonatal mice were randomly divided into 5 equal-sized groups: CTL (control), TAM, PPT, DPN, and G-1. Three months later, all mice were sacrificed and their uterine horns were harvested, weighed, and processed for histological evaluation. Results: All mice in the TAM group developed adenomyosis, so did 4 mice (50%) in the DPN group, a result that should be considered significant given that mice in the CTL group would not develop adenomyosis. No mouse in the PPT or G-1 group developed adenomyosis. Remarkably, all lesions in the DPN group were seen exclusively near the uterine serosa, which are dramatically different from that of TAM mice and reminiscent of extrinsic or external adenomyosis in humans. Conclusions: Neonatal feeding of DPN induces adenomyosis, but the adenomyotic lesions appear to be different from those induced by TAM. Thus, the cause of TAM-induced adenomyosis in ICR/CD-1 mouse cannot be attributable to one specific ER alone. This suggests that the extrinsic/external adenomyosis may have a pathogenesis that is different from other sub-types of adenomyosis.