Miracle-dz/UniFAR-FTUs huggingface dataset:
Hubungan Response Time Seksio Sesarea Emergensi Kategori 1 dengan Luaran Perinatal di RSUP Dr.Sardjito

Background: Caesarean section is often applied as a preventif efoort against the continued effects of perinatal asphyxia. The cesarean section (SC) in pregnant woman can be performed in a planned manner with various indications or performed by emergency (emergency) on maternal or fetal indications and or both. Objective: To study the association of response time in category I emergency caesarean section with perinatal outcomes in Dr. Sardjito hospital and the average response time of category 1 emergency cesarean section in Dr. Sardjito hospital. Method: This study uses retrospective cohort. Category 1 CS with an indication of fetal accordance with the inclusion criteria was recorded from 1st January 2012 until 31th July 2016, then we find the response time mean as the cut off point of this study to compare with their perinatal outcomes. Result and Discussion: There were 155 cases out of 386 of emergency CS category 1 met the inclusion criteria during the period 1st January 2012 to 31th July 2016. From the data obtained, the average response time of category 1 emergency CS was 115±52 minutes (35 - 360 minutes). We found no significant differences in perinatal outcomes in the group’s response time ≥115 minutes with a value of p>0.05 on the Apgar score, CPAP, infant mortality, ventilator, NICU care, MAS and HIE than those category 1 emergency CS with a response time <115 minutes. From multivariate analysis, general anaesthesia was statistically significant against perinatal outcomes Apgar score <7 at 5 minutes with (p=0.044). Prematurity in the multivariate analysis was statistically significant against perinatal outcomes Apgar score ≤3 at 1 minute with (p=0.040), Apgar score <7 at 5 minutes with (p=0.025) and the use of CPAP with (p=0.009). Conclusions: Response time category 1 emergency cesarean section in this study did not affect perinatal outcomes. General anesthesia effect on perinatal outcomes Apgar score <7 at 5 minutes, whereas the prematurity effect on perinatal outcomes Apgar score ≤3 at 1 minute, Apgar score <7 at 5 minutes and the use of CPAP. Keywords: category 1 emergency caesarean section, response time, fetal distress
DISEASE-MODIFYING EFFECTS OF TYPE 2 DIABETES MELLITUS AND BIPOLAR DISORDER COMORBIDITY

ARTICLE INFO ABSTRACT Aim: The aim of this review was to better understand the risks and care issues associated with poorly managed type 2 diabetes mellitus, in relation to poor prognosis of bipolar disorder. Methods: diabetes” OR “Insulin Resistance” AND “Bipolar Disorder” AND “Outcome” AND “Course of illness” in a variety of databases. The publications were all filtered following pre Results: type 2 diabetes, there was association of with the severity of the bipolar disorder. Individuals with bipolar disorder and diabetes mellitus experienced neurodegenerative disorders with more depressive symptoms. Additionally, higher rate of non-compliance was identifi Conclusions: both diabetes mellitus and neuropsychiatric disorders. There is a psychiatric and general medical providers.
Impact Of Japanese Encephalitis And Its Outcome: A Study In Tertiary Care Hospital In North India

BACKGROUND: Studies on Japanese Encephalitis,a leading cause of encephalitis and neurological infections in Asia, are very few. We aim to study the impact of Japanese encephalitis and its outcome in a tertiary care hospital in North India. MATERIAL AND METHOD: A prospective observational study was conducted in patients suffering from viral encephalitis. Routine investigations, computed tomographic scan of head, magnetic resonance imaging brain and CSF analysis were done. RESULTS: Most of the patients were in the age group of 21 to 30 year. Males were more affected than females. After a follow up at 1 month, neuro-sequelae were found to be present in 64.70% patients of JE, with maximum patients having altered behaviour. Proportion of patients who recovered was 15.68 % while 19.60% patients expired. CONCLUSION: Reporting and appropriate workup of the suspected acute viral encephalitis patients is very important to reduce the morbidity and mortality.
Ambidexterity

, Ambidexterity : a term applied when the movements and sensations of the limbs on one side of the body are under equal control and command with those on the opposite side. There seems to be an unwritten and yet unaltered law to the effect that man should use one hand rather than the other as the instrument of his will. That is to say, one of his hands is the active or controlling member in all that he does. Right-handedness means, the right hand is the guiding hand, while in work the left one assists. The union is inseparable. In all work which requires both hands the left does as much work as the right, but only as an as-
Predicting Sudden Death in the Population

Background—Sudden death was found to share the same set of usual risk factors as coronary events and therefore could not be specifically predicted in the population. It appears, however, that parental history of sudden death has not been investigated yet as a risk factor for sudden death. Therefore, we assessed risk factors, including parental sudden death, associated with the occurrence of sudden death in a long-term cohort study. Methods and Results—We included 7746 men employed by the city of Paris who were 43 to 52 years of age in 1967 to 1972 in the Paris Prospective Study I. Each subject underwent a physical examination and an ECG, provided blood for laboratory tests, and answered questionnaires administered by trained interviewers who paid particular attention to family medical history. Men with known ischemic cardiac disease were further excluded from analysis. For 95.5% of the men, vital status was obtained from specific inquiries until retirement, then by death certificates. Resting heart rate, .
Dementia with Lewy Bodies and Parkinson's Disease-Dementia: Current Perspectives

Dementia with Lewy bodies (DLB) and Parkinson’s disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology. Both disorders show notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk factors. Despite considerable clinical similarities, according to international consensus, their diagnosis is based on an arbitrary distinction between the time of onset of motor and cognitive symptoms: dementia preceding parkinsonism in DLB, while it develops after onset of parkinsonism in PDD (the one-year rule). However, despite validitated criteria for DLB and PDD, in almost 50% of the cases, the clinical diagnosis is incorrect, whereas the specificity was below 60%. Clinically, both syndromes show cognitive impairment with severe deficits in executive function, visuo-spatial processing, visual hallucinations, fluctuating attention, REM sleep behaviour diorder (RBD) and parkinsonism, memory disorders being more severe in PDD.
Overall survival of PEGylated pegilodecakin with 5-FU/LV and oxaliplatin (FOLFOX) in metastatic pancreatic adenocarcinoma (PDAC).

4119Background: The therapeutic options for 2nd line therapy PDAC remain unsatisfying with 5-FU/LV plus oxaliplatin or nal-irinotecan resulting in a mOS of 5-6 mo. PDAC has been largely refractory to immune-oncology approaches and CD8+ T cells are rare in most PDAC. AM0010 stimulates survival, expansion and cytotoxicity of intratumoral CD8+ T cells. Immune activation, durable stable disease and a 1yr survival of 22.5% was seen in salvage PDAC patients (pts) receiving AM0010 alone. AM0010 has synergistic anti-tumor activity with 5-FU/LV or oxaliplatin in preclinical models. Here we report on the safety, efficacy and overall survival of AM0010 + FOLFOX as 2nd and later line treatment in PDAC pts. Methods: PDAC pts progressing on a median of 2 prior therapies (range 1-5) were treated with AM0010 (5ug/kg SQ, qd) + FOLFOX (n = 21). The safety population (n = 25) included also 4 pts with prior oxaliplatin / 5-FU. Tumor responses were assessed with irRC. The survival population included all patients without prio.
Stacked Autoencoders for the P300 Component Detection

Novel neural network training methods (commonly referred to as deep learning) have emerged in recent years. Using a combination of unsupervised pre-training and subsequent fine-tuning, deep neural networks have become one of the most reliable classification methods. Since deep neural networks are especially powerful for high-dimensional and non-linear feature vectors, electroencephalography (EEG) and event-related potentials (ERPs) are one of the promising applications. Furthermore, to the authors' best knowledge, there are very few papers that study deep neural networks for EEG/ERP data. The aim of the experiments subsequently presented was to verify if deep learning-based models can also perform well for single trial P300 classification with possible application to P300-based brain-computer interfaces. The P300 data used were recorded in the EEG/ERP laboratory at the Department of Computer Science and Engineering, University of West Bohemia, and are publicly available. Stacked autoencoders (SAEs) were implemented and compared with some of the currently most reliable state-of-the-art methods, such as LDA and multi-layer perceptron (MLP). The parameters of stacked autoencoders were optimized empirically. The layers were inserted one by one and at the end, the last layer was replaced by a supervised softmax classifier. Subsequently, fine-tuning using backpropagation was performed. The architecture of the neural network was 209-130-100-50-20-2. The classifiers were trained on a dataset merged from four subjects and subsequently tested on different 11 subjects without further training. The trained SAE achieved 69.2% accuracy that was higher (p < 0.01) than the accuracy of MLP (64.9%) and LDA (65.9%). The recall of 58.8% was slightly higher when compared with MLP (56.2%) and LDA (58.4%). Therefore, SAEs could be preferable to other state-of-the-art classifiers for high-dimensional event-related potential feature vectors.
Comparison of laparoscopic-assisted vaginal hysterectomy, total abdominal hysterectomy and vaginal hysterectomy: A four years retrospective study in tertiary care centre

Background: Hysterectomy is one of the commonest gynaecological operations performed in India. Traditional surgical treatments performed are abdominal hysterectomy and vaginal hysterectomy. Vaginal and laparoscopic procedures are considered “minimally invasive” surgical approaches because they do not require a large abdominal incision and, thus, typically are associated with shortened hospitalization and postoperative recovery times compared with open abdominal hysterectomy. With the aid of laparoscopic procedure, a potential abdominal hysterectomy can be converted to a vaginal one and a difficult vaginal hysterectomy can be converted into a fairly simple vaginal hysterectomy. Aim of the present study is to compare above methods of hysterectomy in terms of operating time, estimated blood loss, and postoperative hospital stay and complication, so as to provide best course of treatment to patient.Methods: A retrospective observational study was conducted in tertiary care centre. Four-year data was collected from January 2012 to December 2016. Cases of LAVH with benign gynaecological condition and up to 12 weeks size uterus, without any associated medical condition were selected in study randomly, and compare with cases of NDVH, TAH in terms of duration of operative procedure, blood loss during surgery, and postoperative hospital stay.Results: In present study we found that average duration of procedure in LAVH was 84.35 minute, which was maximum compare to other method. Estimated blood loss in LAVH was least as compare to NDVH and TAH it was maximum. The average hospital stays in LAVH and NDVH was less as compared to TAH.Conclusions: LAVH should be considered a better approach in view of the relatively less blood loss and intraoperative complication. Due to lack of large randomized controlled trials, the role of Laparoscopic hysterectomy is difficult to define.
Is there a best approach to the rehabilitation of adult hemiplegia?

Abstract Established neuro-rehabilitation approaches to the remediation of hemiplegia have been the mainstay of stroke rehabilitation. Approaches such as proprioceptive neuromuscular rehabilitation, neurodevelopmental treatment for adult hemiplegia, motor relearning program, task specific training and constraint induced movement therapy have all been supported in the literature. While research has supported their efficacy, efforts to establish the most effective approach have been unsuccessful, often inconsistent and sometimes controversial. The evolution of rehabilitation approaches occurring in time with the general acceptance that neuroplastic changes are driven by experience has resulted in the approaches working from a number of common elements that tap into the principles of neuroplasticity. The aim of this perspective article is to challenge the concept that there is a “best” approach to the rehabilitation of adult hemiplegia. It will present a sample of literature relating to the efficacy of neuro-approaches and the literature comparing approaches, identify elements common to the frequently applied approaches, identify the principles of neuroplasticity and demonstrate how each of the approaches taps into a number of these principles. The correlation between the elements common to the neuro-rehabilitation approaches and the principles of neuroplasticity they tap into is proposed as a theory to explain the challenge in establishing the superiority of one approach over another. Employment of an eclectic approach based on patient needs and responses to rehabilitation of adult hemiplegia is presented as a reasonable conclusion.
Association between depression and chronic diseases: results from a population-based study

OBJECTIVE: To assess the association between depression and chronic diseases in adults. METHODS: Population-based cross-sectional study with a sample of 1,720 adults aged 20 to 59 years conducted in the city of Florianopolis, southern Brazil, in 2009. Multistage sampling was used and census tracts were the primary sample unit. Subjects were interviewed at home, and reported being diagnosed with depression (outcome) and 11 other chronic diseases (exploratory variable) by a health provider. They were grouped into those with no chronic disease, one, and two or more diseases. Gender, age, marital status, income, physical activity, hospitalization and medical visits were confounders. Poisson regression analysis was used to estimate prevalence ratios and related 95% confidence intervals. RESULTS: The prevalence os depression was 16.2% (95%CI 14.3;18.2). It was higher in women, older individuals, widowed or divorced, and poor ones. Those who reported no leisure-time physical activity and medical visits in the last two weeks, and who were hospitalized in the last year also showed higher prevalence of depression and chronic diseases. Even after adjustment for confounders the prevalence of depression was 1.44 (95%CI 1.09;1.92) times higher among those reporting one chronic disease and 2.25 times higher among those reporting two or more diseases than among those with no diseases. CONCLUSIONS: The prevalence of depression is much higher among people with higher burden of chronic diseases. Health professionals, health services, and policy makers must target specific strategies to this group.
Discovery of organellar calcium signaling components in Arabidopsis thaliana

My thesis is focused on the role of organelles in plant calcium signaling. Plants and other eukaryotic organisms use calcium ions as secondary messengers in order to acclimate rapidly to changes of the environment or to assist in developmental programs. The importance of calcium signaling on plant physiology is well established today, but has so far focused mainly on calcium signaling in the cytosol. To get insights into plant organellar calcium signaling, I have studied the impact of calcium on plastids, mitochondria and peroxisomes, and to a minor extent also the influence of these organelles on calcium signaling in the rest of the cell. Initially, I started with a search for calcium binding proteins in the chloroplast by targeted proteomics and data mining. However, the results of this work were in the end not only restricted to plastids as I discovered novel calcium signaling components of the mitochondria and peroxisomes. The proteomic approaches resulted in the identification of two confirmed chloroplast calcium binding proteins. LENA (Little E-enriched protein A) is predicted to be a protein component of the long-hypothesized calcium storage of the plastid. SAMTL (S-adenosyl methionine transporter-like) is a member of the mitochondrial carrier family and predicted to transport SAM into chloroplasts in a calcium-dependent manner. The three calcium-dependent mitochondrial carrier family (MCF) proteins, APC1, 2 and 3 (ATP/phosphate carriers 1, 2 and 3) localize to mitochondria. Phylogenetic analysis and complementation of yeast mutants suggested APC1, 2 and 3 to be mitochondrial ATP importers, which could be needed during periods of anoxia. Furthermore an organellar EF-hand protein of 18 kDa (OEF18) was discovered in the course of a study on the impact of protein N-acylation for organellar targeting. This protein was identified by data mining as well as in the proteomic approach. Subsequent work showed that OEF18 is dually targeted to the plastid outer envelope and peroxisomal membrane and might be involved in the process of organellar division. In addition to my approaches to identify novel organellar Ca binding proteins, I have studied a potential crosstalk between calcium signaling and protein phosphorylation in chloroplasts. Three chloroplast proteins, PsaN (subunit N of Photosystem I), the FstH protease VAR1 (Variegated 1) and CAS (Calcium sensing protein) were conclusively found to be phosphorylated in a calcium dependent manner. The implications of this novel regulation are speculative, but the presented findings provide a stable base to further investigate the impact of calcium dependent protein phosphorylation on chloroplast function.
Epilepsy Surgery in Pediatric Patients: A Single-Center Experience

Amaç: İlaca dirençli epilepsi hastalığında epilepsi cerrahisi uygun olgularda etkili tedavi yöntemlerinden biridir. Bu çalışmadaki amacımız kliniğimizde epilepsi cerrahisi uygulanan çocukluk çağı ilaca dirençli epilepsi hastalarının demografik veri, ameliyat başarısı, olası cerrahi komplikasyonlar ve ameliyat başarısına etki eden faktörleri araştırmak ve çocukluk çağı epilepsi cerrahisi klinik tecrübemizi paylaşmaktır. Gereç ve Yöntem: Bu geriye dönük çalışmaya kliniğimizde 2005–2017 yılları arasında ilaca dirençli epilepsi nedeni ile epilepsi cerrahisi yapılan 85 çocuk hasta dahil edilmiştir. Yaş, cinsiyet, nöbetin başlama yaşı, tarafı, sıklığı, nöbet başlangıcı ile ameliyat arasındaki zaman, epilepsi cerrahisi çeşidi ve histopatoloji değişkenleri ile cerrahi başarının arasındaki ilişki araştırılmıştır. Cerrahi başarı Engel sınıflaması ile ölçeklendirilmiştir. Veriler SPSS 20.0 programı ile analiz edilmiştir. Bulgular: Araştırmaya dahi edilen hastalarının 56’sı (%66) erkek, 29’u (%34) kadındır. Nöbet başlama medyan yaşı ikidir (1 gün–15 yıl). Ameliyat zamanındaki medyan yaş 6.2’ dir (3 ay–16 yıl). Nöbet başlangıcı ile cerrahi arasında geçen medyan yıl 3.2’dir (3 ay–15.5 yıl). Medyan takip süresi 5.6 yıldır (3 ay–13.5 yıl). Hastaların üçünde (%3.5) kalıcı motor kayıp gelişmiştir. En yüksek cerrahi başarı rezektif cerrahi yapılan hastalarda izlenmiştir (p<0.01). Ameliyat sonrası cerrahi başarıyı en çok etkileyen faktör nöbet başlama yaşıdır (p<0.05). Sonuç: Epilepsi cerrahisi, doğru seçilmiş çocukluk çağı ilaca dirençli epilepsi hastalarında akılda tutulması gereken güvenli ve etkili tedavi seçeneklerinden biridir.
Characteristics of Primary Hyperparathyroidism Patients Based on One Saudi Center Experience

Introduction: The prevalence and presentation of the Primary Hyperparathyroidism (PHPT) geographically varies. There is a paucity of published literature on PHPT in Saudi Arabia, so this study aimed to investigate the characteristic features and the surgical outcome of PHPT patients. Methods: A retrospective review of PHPT patients underwent parathyroidectomy at King Faisal Specialist Hospital and Research Center, from 2010 to 2016. Results: There were 88 patients; 72 (81.8%) were female and 16 (18.2%) were male. The mean age was 46 ± 15 year. The mean preoperative serum level was 2.85 ± 0.33 for calcium and 407 ± 475 for parathyroid hormone. The majority of the cases presented with bone symptoms 50 patients (56.8%), followed by no symptoms in 25 patients (28.4%), fatigability 7 (7.9%), renal symptoms 4 (4.6%) and gastric symptoms 2 (2.3%). Sestamibi scanning localized diseased gland in 71 cases (81.6%). The causes of PHPT were single adenoma in 75 (85.2%), double adenoma in 6(6.8%) and hyperplasia in 7(8%). The persistent rate was 1.1% and the recurrent rate was 2.2%. Females found to have a lower preoperative vitamin D level comparing with males 39.7 nmol/L ± 28.6 nmol/L vs. 73.87 nmol/L ± 19.73 nmol/L (p= 0.0001). Moreover, patients with multiple gland disease had a higher rate of recurrence comparing with patients with single adenoma 0% vs. 15.4% (p=0.020). Conclusion: While half of PHPT patients in Saudi Arabia still present with bone symptoms, one fourth of the cases are asymptomatic. Moreover, one third of the cases are younger than 40 years old.
THROMBOLYSIS AND EARLY SPEECH AND LANGUAGE RECOVERY AFTER STROKE

OF DISSERTATION THROMBOLYSIS AND EARLY SPEECH AND LANGUAGE RECOVERY AFTER STROKE Speech and language impairments after left hemisphere stroke are life altering. Neuroprotective interventions, such as tissue plasminogen activator, or tPA, are utilized to diminish the impact of the stroke on functional ability. The purpose of this study was to examine speech and language recovery in the first three months after stroke in individuals with aphasia and to further investigate any differences between individuals who did and individuals who did not receive tPA, using objective speech and language measures. Twenty-six individuals, thirteen of whom received tPA and thirteen who did not, suffering from first-ever left hemisphere stroke with resulting aphasia were enrolled and completed repeated speech and language assessments within 24 hours after stroke, at one and two weeks after stroke. A three month assessment also included an additional quality of life measure. Findings indicate that both individuals who did and those who did not receive tPA demonstrated significant gains in language skills. Results also suggest that the individuals who received tPA have better outcomes at three months compared to those who did not. This is clinically significant as it helps provide prognostic information about the use of tPA and informs decision making for speech pathologists within the acute care hospital.
hubungan status gizi ibu hamil dengan kejadian anemia pada ibu hamil

Tujuan dari penelitian ini mengetahui hubungan status gizi ibu hamil dengan kejadian anemia. Rancangan penelitian menggunakan desain case control dan sampel yang di gunakan adalah 1:1. Maka sampel untuk kelompok kasus yang digunakan dalam penelitian ini adalah seluruh ibu hamil yang mengalami anemia 99 orang dari populasi 730 . Hasil uji statistik dengan menggunakan chi square pada α=0,05 didapatkan nilai P sebesar 0,000 (P < 0,05) yang bermakna secara statistik terdapat hubungan yang bermakna status gizi ibu hamil dengan kejadian anemia di Puskesmas Rangkasbitung tahun 2014. Oleh karena itu, melihat masih banyak kasus anemia, maka tenaga kesehatan diharapkan lebih sigap dan tanggap serta selalu meningkatkan kemampuan, sehingga dapat memberikan informasi melalui penyuluhan kesehatan terhadap ibu hamil yang mengalami anemia. faktor-faktor penyebab anemia serta mendukung program ANC denga 10T yang salah satunya:, Nilai status gizi (ukur lingkar lengan atas).