Miracle-dz/UniFAR-FTUs huggingface dataset:
The Validation of a Pocket Worn Activity Tracker for Step Count and Physical Behavior in Older Adults during Simulated Activities of Daily Living

Purpose: The purpose of this study was to validate optimized algorithm parameter settings for step count and physical behavior for a pocket worn activity tracker in older adults during ADL. Secondly, for a more relevant interpretation of the results, the performance of the optimized algorithm was compared to three reference applications Methods: In a cross-sectional validation study, 20 older adults performed an activity protocol based on ADL with MOXMissActivity versus MOXAnnegarn, activPAL, and Fitbit. The protocol was video recorded and analyzed for step count and dynamic, standing, and sedentary time. Validity was assessed by percentage error (PE), absolute percentage error (APE), Bland-Altman plots and correlation coefficients. Results: For step count, the optimized algorithm had a mean APE of 9.3% and a correlation coefficient of 0.88. The mean APE values of dynamic, standing, and sedentary time were 15.9%, 19.9%, and 9.6%, respectively. The correlation coefficients were 0.55, 0.91, and 0.92, respectively. Three reference applications showed higher errors and lower correlations for all outcome variables. Conclusion: This study showed that the optimized algorithm parameter settings can more validly estimate step count and physical behavior in older adults wearing an activity tracker in the trouser pocket during ADL compared to reference applications.
Perceptions of Victim Advocates and Predictors of Service Referral Among Law Enforcement Personnel

Limited research exists on police officers’ service provision for sexual and domestic violence survivors after they formally report. This study used surveys from 452 commissioned officers at an urban police department in one of the five largest and most diverse U.S. cities to examine police perceptions of victim advocates, self-reported frequency of referral, and predictors of service referral among police. Findings revealed officers were relatively likely to provide referrals and held somewhat favorable attitudes of advocates. Knowledge of services and positive perceptions of advocates increased the frequency of service referral to victims. Implications and future research directions are discussed.
Identification and functional characterization of a novel PAX8 mutation (p.His39Pro) causing familial thyroid hypoplasia

Abstract. Mutations in PAX8, the gene for a thyroid-specific transcription factor, causes congenital hypothyroidism (CH) with autosomal dominant inheritance. All previously detected PAX8 mutations except one are located in the DNA-binding paired domain. The proband, a 1-yr-old boy, was diagnosed with CH in the frame of newborn screening. He had high serum TSH level (180 mU/L) and low serum free T4 level (0.4 ng/dL). Ultrasonography revealed that the proband had thyroid hypoplasia. Importantly, he had a family history of CH, i.e., his mother also had CH and hypoplasia. Next generation sequencing-based mutation screening revealed a novel heterozygous PAX8 mutation (c.116A>C, p.His39Pro) that was transmitted to the proband from the mother. Expression experiments with HeLa cells confirmed that His39Pro-PAX8 exhibited defective transactivation of the TG promoter–luciferase reporter. In conclusion, we identified and described a novel loss-of-function PAX8 mutation in a family with thyroid hypoplasia. Patients with dominantly inherited CH and no extrathyroidal abnormalities could have PAX8 mutations.
Intravenous immunoglobulin immunotherapy for coronavirus disease‐19 (COVID‐19)

Intravenous immunoglobulin (IVIG), a pooled normal IgG from several thousand healthy donors and one of the commonly used immunotherapeutic molecules for the management of autoimmune and inflammatory diseases, has been explored for the treatment of coronavirus disease‐19 (COVID‐19). Although placebo‐controlled, double‐blind randomised clinical trials are lacking, current data from either retrospective, case series or open‐label randomised controlled trials provide an indicator that IVIG immunotherapy could benefit severe and critically ill COVID‐19 patients. See alsoShao et al.
Lactobacillus pentosus Increases the Abundance of Akkermansia and Affects the Serum Metabolome to Alleviate DSS-Induced Colitis in a Murine Model

Lactobacillus pentosus has the beneficial function of regulating the host’s immune system and plays an indispensable role in intestinal health. The purpose of this study was to investigate the specific mechanism by which L. pentosus relieves dextran sulfate sodium (DSS) induced ulcerative colon inflammation. We randomly divided 24 mice into three groups, which were administered either a basic diet, drinking water with 2.5% DSS (DSS), or drinking water with 2.5% DSS and intragastric administration of L. pentosus (DSS + L. pentosus). DSS was added to the drinking water on days 8 to 12, and L. pentosus was administered on days 12 to 19. Serum was collected for metabolomic analysis, colon length and weight were measured, and colon contents were collected to detect microbial structural composition. Compared with the DSS group, the DSS + L. pentosus group had significantly higher levels of indolepyruvate and pantothenic acid in the serum and significantly lower levels of 3,4-dimethyl-5-pentyl-2-furannonanoic acid and 5-oxo-6-trans-leukotriene B4. Moreover, compared with the other two groups, the DSS + L. pentosus group had a significantly greater abundance of Akkermansia. The abundance of Akkermansia was positively correlated with indolepyruvate and pantothenic acid levels. Therefore, L. pentosus can interact with Akkermansia to increase its abundance in the intestinal tract. This results in the production of metabolites that are beneficial for the regulation of intestinal immunity, thereby alleviating DSS-induced ulcerative colon inflammation.
Macroscopic Modeling of Fingerpad Friction Under Electroadhesion: Possibilities and Limitations

Electrovibration is one of the key technologies in surface haptics. By inducing controlled electrostatic forces, the friction within a sliding contact between the human finger and a capacitive screen is modulated, which in turn gives effective tactile feedback to the user. Such powerful haptic displays can be built into mobile phones, tablets, navigation devices, games consoles and many other devices of consumer electronics. However, due to the layered structure and complex material of human skin, the underlying contact mechanical processes have not yet been fully understood. This work provides new continuum-based approaches to macroscopic modeling of the electro-adhesive frictional contact. A solution of pure normal contact between a human finger and a rigid, smooth plane under electroadhesion is derived by applying Shull's compliance method in the extended regime of large deformations. Based on these results and assuming pressure-controlled friction, a model for the sliding electro-adhesive contact is developed, which adequately predicts the friction force and coefficient of friction over the whole range of relevant voltages and applied normal forces. The experimentally observed area reduction caused by the tangential force is incorporated in a more empirical than profound contact mechanical way. This effect is studied with the help of a two-dimensional finite element model of the fingertip, assuming non-linear elastic material for the skin tissue. Although the simulations are restricted to non-adhesive tangential contacts, they show a significant reduction of the contact area, which is caused by large deformations of the non-linear elastic material around the distal phalanx. This result indicates that adhesion is only of secondary importance for the area reduction.
Resonator Networks, 2: Factorization Performance and Capacity Compared to Optimization-Based Methods

We develop theoretical foundations of resonator networks, a new type of recurrent neural network introduced in Frady, Kent, Olshausen, and Sommer (2020), a companion article in this issue, to solve a high-dimensional vector factorization problem arising in Vector Symbolic Architectures. Given a composite vector formed by the Hadamard product between a discrete set of high-dimensional vectors, a resonator network can efficiently decompose the composite into these factors. We compare the performance of resonator networks against optimization-based methods, including Alternating Least Squares and several gradient-based algorithms, showing that resonator networks are superior in several important ways. This advantage is achieved by leveraging a combination of nonlinear dynamics and searching in superposition, by which estimates of the correct solution are formed from a weighted superposition of all possible solutions. While the alternative methods also search in superposition, the dynamics of resonator networks allow them to strike a more effective balance between exploring the solution space and exploiting local information to drive the network toward probable solutions. Resonator networks are not guaranteed to converge, but within a particular regime they almost always do. In exchange for relaxing the guarantee of global convergence, resonator networks are dramatically more effective at finding factorizations than all alternative approaches considered.
Super User Influence Detection Algorithm in Microblog Networks

In a Microblog (i.e., Weibo) network, there are special users who induce other users to actively utilize microblogs. Identifying such influential users is important when establishing business strategy and models for the Microblog network. In this paper we focus on the research of the Sina Micro-blog. First of all, we tried using a new way to define the super users whose micro-blogs exhibit significant influences over other users. The new definition can classify or cluster these super users in a different perspective. Second, we constructed a model based on the dissemination of micro-blogs and the actions of users; this model can explain the diffusion of micro-blogs' influence and can successfully describe the impact of the propagation and dissemination of the information in the Micro-blog network. Third, we proposed a method of identifying the super users, called User Influence Detection Algorithm Based on Micro-blog's Spreading Cascade, referred to as UISC Algorithm. What's more, we analyzed the performance of the proposed method by applying it to an actual Micro-blog network and the experimental results show that the UISC outperforms other methods we compared.
Sochiatrist

Messaging is a common mode of communication, with conversations written informally between individuals. Interpreting emotional affect from messaging data can lead to a powerful form of reflection or act as a support for clinical therapy. Existing analysis techniques for social media commonly use LIWC and VADER for automated sentiment estimation. We correlate LIWC, VADER, and ratings from human reviewers with affect scores from 25 participants. We explore differences in how and when each technique is successful. Results show that human review does better than VADER, the best automated technique, when humans are judging positive affect ($r_s=0.45$ correlation when confident, $r_s=0.30$ overall). Surprisingly, human reviewers only do slightly better than VADER when judging negative affect ($r_s=0.38$ correlation when confident, $r_s=0.29$ overall). Compared to prior literature, VADER correlates more closely with PANAS scores for private messaging than public social media. Our results indicate that while any technique that serves as a proxy for PANAS scores has moderate correlation at best, there are some areas to improve the automated techniques by better considering context and timing in conversations.
Social Determinants of Myocardial Infarction Risk and Survival: A Systematic Review

Social determinants of health that have been examined in relation to myocardial infarction incidence and survival include socioeconomic status (income, education), neighbourhood disadvantage, immigration status, social support, and social network. Other social determinants of health include geographic factors such as neighbourhood access to health services. Socioeconomic factors influence risk of myocardial infarction. Myocardial infarction incidence rates tend to be inversely associated with socioeconomic status. In addition, studies have shown that low socioeconomic status is associated with increased risk of poorer survival. There are well-documented disparities in myocardial infarction survival by socioeconomic status, race, education, and census-tract-level poverty. The results of this review indicate that social determinants such as neighbourhood disadvantage, immigration status, lack of social support, and social isolation also play an important role in myocardial infarction risk and survival. To address these social determinants and eliminate disparities, effective interventions are needed that account for the social and environmental contexts in which heart attack patients live and are treated.
Physico-Chemical and Microbiological Analysis of Water of the “Presa De Los Patos” in the Desierto De Los Leones National Park, Mexico

The Desierto de los Leones National Park is a place that features recreational activities for residents and visitors to Mexico City. The Presa de los Patos (Ducks Dam) is one of the many bodies of water that are present in the park. By means of physico-chemical and microbiological analysis, it was determined that the water of the Presa de los Patos cannot be considered potable. The pH range was between 5.5 - 5.9. The turbidity exceeded the values established in the standards (10.7 - 32.3 Nephelometric Turbidity Units (NTU’s)). Chemical Oxygen Demand (COD) showed that large amounts of oxygen are needed to oxidize organic matter (106 - 450 mg/L). The amount of coliforms and fecal coliforms exceeds the values established by the standards used (total coliforms 98 - 956 Colony Forming Units (CFU’s), fecal coliforms 78 - 807 CFU’s). Five bacterial genera (Escherichia coli, Pseudomona, Klebsiella, Shigella and Salmonella) were isolated and identified. Most of the bacteria isolated were resistant to ampicillin (90%), while 25% were resistant to ciprofloxacin. The water consumption of the Presa de los Patos is a great risk for the habitants and visitors of the park.
Injury-related deaths in Enugu, Nigeria from 2010 to 2016: a descriptive review

Introduction death from injuries is a global public health problem. Ninety percent occur in low- and middle-income countries like Nigeria. This study aimed to determine the burden and demographic characteristics of injury-related death in Enugu, Nigeria. Methods this is a retrospective study of injury-related deaths in Enugu over a 7-year period. Standardized forms were used to collect data from autopsy reports archived in the Forensic Unit of Enugu State University Teaching Hospital, Enugu and a descriptive analysis of collected data performed. Results of the Coroner deaths examined in the period reviewed, 1,067 (86.9%) were injury-related. The male-to-female ratio was 5.2: 1. Mean age of victims was 34.2 ± 14.3years and range was 8 months to 86 years. Most victims (56.7%) aged 21-40 years. Accidents accounted for most deaths (53.2%) followed by homicide (44.3%). Road traffic deaths (51.4%), cult/gang violence (20.8%) and robbery (14.7%) were the commonest. Suicide (0.5%) and domestic violence (0.7%) were the least. More females died in domestic incidents while more males died in all other circumstances. Firearm (56.7%) was the most common weapon followed by knife (19%). Knife and wood (28.7% each) were the commonest weapons in domestic violence. Generally, fatal incidents occurred more in the day-time (65.5%). Most robberies (80.4%) occurred at night. Most cult/gang killings (75.2%) and robberies (81.7%) occurred in public places and at homes respectively. Conclusion injury is the highest source of Coroner's death in Enugu. Efforts to curb it are insufficient. A definitive policy on the prevention and management of injury-related deaths is needed.
New strategies for prevention of E. coli O157:H7 infection in sheep

s and Poster Atef Yekta, M. , De Reu, K. , Joris, R. , Vanrompay, D. , Boyen, F. , Cox, E. , Haesebrouck, F. Isolation, identification and antimicrobial resistance patterns of STEC. 7th International Symposium on Shiga Toxin (Verocytotoxin) producing Escherichia coli infections (VTEC2009). 2009.Buenos Aires, Argentina (abstract and poster presentation). Atef Yekta, M. , Vanrompay D. , Goddeeris B. , Cox E. , Isolation, identification and antimicrobial resistance patterns of STEC isolated from poultry and bovine. Oral presentation. First international congress of food microbiology. 2009. Tehran, Iran. Atef Yekta, M. , Verdonck, F. , Goddeeris, B. , Cox, E. , Vanrompay, D . Lactoferrin reduces E. coli O157:H7 attachment to sheep intestinal explants. Pathogenic E.coli Network Conference, Epidemiology and transmission of pathogenic E. coli. 25-26 September 2008. Stockholm, Sweden (abstract and poster presentation). Atef Yekta, M. , Verdonck, F. , Goddeeris, B. , Cox, E. , Vanrompay, D. In vitro effects of lactoferrin on growth and attachment to HEP-2 cells of E. coli O157:H7. E. coli Genomic congress. 2007. Utrecht, The Netherlands (abstract and poster presentation). Vande Walle, K. , Atef Yekta, M. , De Zutter, L. , Goddeeris B. , Cox E. , Verdonck, F. Development of an E. coli O157:H7 infection model in sheep. EADGENE E. coli and
Group B Streptococci Induce Interleukin 8 Production in Human Cervical Epithelial Cell Cultures: The Role of Capsule Polysaccharide

Objective: Group B streptococci (GBS) are the major cause of pneumonia, sepsis, and meningitis in neonates and adults. Epithelial invasion and early cytokine response of female genital tract considered to be important in the pathogenesis of GBS infection. In this study, we studied the IL-8 induction in cervical epithelial cells in response to stimulus with encapsulated (COH1) and unencapsulated (COH1-13) strains of group B streptococci. Methods: Human cervical epithelial cancer cell (HeLa) cultures were stimulated with different concentrations (106 CFU/ml and 108 CFU/ml) of two GBS strains. E.coli LPS was used as positive control and at specified time points (4, 8 and 24 hour) cell culture supernatant samples were collected. IL-8 level in samples was quantified by using ELISA assay. Results: Both GBS strains caused an equal IL-8 response in HeLa cells in a time-dependent manner. In addition, cytokine levels triggered by different bacterial concentrations were similar and comparable with LPS. Conclusion: Our study showed that GBS induce proinflammatory IL-8 levels in cervix epithelial cells. This induction seems to be independent from capsule polysaccharides and suggesting that other bacterial components are involved in IL-8 stimulation.
The Cerebellum on Cocaine

The traditional cerebellum’s role has been linked to the high computational demands for sensorimotor control. However, several findings have pointed to its involvement in executive and emotional functions in the last decades. First in 2009 and then, in 2016, we raised why we should consider the cerebellum when thinking about drug addiction. A decade later, mounting evidence strongly suggests the cerebellar involvement in this disorder. Nevertheless, direct evidence is still partial and related mainly to drug-induced reward memory, but recent results about cerebellar functions may provide new insights into its role in addiction. The present review does not intend to be a compelling revision on available findings, as we did in the two previous reviews. This minireview focuses on specific findings of the cerebellum’s role in drug-related reward memories and the way ahead for future research. The results discussed here provide grounds for involving the cerebellar cortex’s apical region in regulating behavior driven by drug-cue associations. They also suggest that the cerebellar cortex dysfunction may facilitate drug-induced learning by increasing glutamatergic output from the deep cerebellar nucleus (DCN) to the ventral tegmental area (VTA) and neural activity in its projecting areas.
Unpacking the motivations, satisfaction and loyalty of tourists travelling to a distressed destination

ABSTRACT The study investigates the travel motivations, satisfaction and loyalty of tourists visiting a destination (under distress). Furthermore, the current study examines the challenges faced by tourists when visiting politically and economically unstable destinations, such as Zimbabwe. Drawing upon a sample of international tourists that visited Zimbabwe’s popular destinations, the results showed that tourists are motivated by scenery, solitude, excitement and thrills as well as social dimensions. The critical challenges of visiting a distressed destination were also identified, and key among them include higher prices and excessive police roadblocks. The travel motivation dimensions and challenges were identified using exploratory factor analysis. Further analyses were done using correlations and regression analyses. Both linear and non-linear relationships were observed and discussed. Thus, the study yields essential results regarding the nature of travel motivations, satisfaction and loyalty in destinations with distress, as well as the challenges tourists face during their visit and stay.
Development of HFD‐Fed/Low‐Dose STZ‐Treated Female Sprague‐Dawley Rat Model to Investigate Diabetic Bone Fragility at Different Organization Levels

Type 2 diabetes (T2D) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, and bone fragility is one of them. To simulate human T2D and to investigate diabetic bone fragility, many rodent diabetic models have been developed. Still, an outbred genetically normal nonobese diabetic rat model is not available that can better simulate the disease characteristics of nonobese T2D patients, who have a high prevalence in Asia. In this study, we used a combination treatment of high‐fat diet (4 weeks, 58% kcal as fat) and low‐dose streptozotocin (STZ; 35 mg/kg i.p. at the end of the fourth week) to develop T2D in female Sprague‐Dawley (SD) rats. After 8 weeks of the establishment of the T2D model, the femoral bones were excised after euthanizing rats (animal age approximately 21 to 22 weeks; n = 10 with T2D, n = 10 without diabetes). The bone microstructure (μCT), mechanical, and material properties (three‐point bending, cyclic reference point indentation, nanoindentation), mean mineral crystallite size (XRD), bone composition (mineral‐to‐matrix ratio, nonenzymatic cross‐link ratio [NE‐xLR], Fourier transform‐infrared microspectroscopy), and total fluorescent advanced glycation end products were analyzed. We found that diabetic bone had reduced whole‐bone strength and compromised structural properties (μCT). The NE‐xLRs were elevated in the T2D group, and strongly and negatively correlated with postyield displacement, which suggests bone fragility was caused by a lack of glycation control. Along with that, the decreased mineral‐to‐matrix ratio and modulus, increased indentation distance increase, and wider mineral crystallite size in the T2D group were evidence that the diabetic bone composition and material properties had changed, and bone became weaker with a tendency to easily fracture. Altogether, this model simulates the natural history and metabolic characteristics of late‐stage T2D (insulin resistance and as disease progress develops, hypoinsulinemia) for nonobese young (and/or adolescent) T2D patients (Asians) and provides potential evidence of diabetic bone fragility at various organization levels. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.