Miracle-dz/UniFAR-FTUs huggingface dataset:
Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling

Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species (ROS) signalling, iron homeostasis and mitochondrial bioenergetics. The transcription factor nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF2), a master regulator of cytoprotective responses, drives the expression of genes that provide resistance to oxidative, electrophilic and xenobiotic stresses. Recent research has suggested that stimulation of the NRF2 signalling pathway can alleviate cardiotoxicity and hallmarks of cardiovascular disease progression. However, dysregulation of NRF2 dynamic responses can be severely impacted by ageing processes and off-target toxicity from clinical medicines including anthracycline chemotherapeutics, rendering cells of the cardiovascular system susceptible to toxicity and subsequent tissue dysfunction. This review addresses the current understanding of NRF2 mechanisms under homeostatic and cardiovascular pathophysiological conditions within the context of wider implications for this diverse transcription factor.
Propagation des singularités des solutions d'équations pseudo-différentielles quasi-homogènes

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The Impact of MOSE (Experimental Electromechanical Module) Flood Barriers on Microphytobenthic Community of the Venice Lagoon

MOSE is a system of mobile gates engineered to temporarily isolate the Venice Lagoon from the Adriatic Sea and to protect the city from flooding during extreme high tides. Within the framework of the Venezia2021 program, we conducted two enclosure experiments in July 2019 (over 48 h) and October 2020 (over 28 h) by means of 18 mesocosms, in order to simulate the structural alterations that microphytobenthos (MPB) assemblages might encounter when the MOSE system is operational. The reduced hydrodynamics inside the mesocosms favored the deposition of organic matter and the sinking of cells from the water column towards the sediment. Consequently, MPB abundances increased over the course of both experiments and significant changes in the taxonomic composition of the community were recorded. Species richness increased in summer while it slightly decreased in autumn, this latter due to the increase in relative abundances of taxa favored by high organic loads and fine grain size. By coupling classical taxonomy with 18S rRNA gene metabarcoding we were able to obtain a comprehensive view of the whole community potential, highlighting the complementarity of these two approaches in ecological studies. Changes in the structure of MPB could affect sediment biostabilization, water turbidity and lagoon primary production.
How fast is too fast? : rate-induced bifurcations in multiple time-scale systems

This thesis studies the phenomenon of rate-induced bifurcations. Externally forced systems may have a critical rate above which they undergo some sort of destabilisation, and move away suddenly to a new state. Mathematically, the phenomenon is a nonautonomous instability. We present a framework in which rate-induced bifurcations can be studied. This is based on geometric singular perturbation theory which is derived from Fenichel’s Theorem. In particular we make use of folded singularities and canard trajectories, which are modern concepts from geometric singular perturbation theory. We concentrate on systems with multiple time-scales where the mechanism for a rateinduced bifurcation is not obvious. So much so, that once a multiple time-scale system has undergone a rate-induced bifurcation, the instability threshold which separates initial states that destabilise from those that adiabatically follow a changing stable state is described as non-obvious. We study in detail the complicated non-obvious instability threshold that arises near a folded saddle-node (type I) singularity. In particular, we show how the complicated threshold structure depends on two parameters – the ratio of timescales and the folded singularity bifurcation parameter. In contrast, we also show single time-scale systems where the rate-induced bifurcation is caused by a large perturbation in the boundary of the basin of attraction for the stable state.
Deep-Learning-Based COVID-19 Diagnosis and Implementation in Embedded Edge-Computing Device

The rapid spread of coronavirus disease 2019 (COVID-19) has posed enormous challenges to the global public health system. To deal with the COVID-19 pandemic crisis, the more accurate and convenient diagnosis of patients needs to be developed. This paper proposes a deep-learning-based COVID-19 detection method and evaluates its performance on embedded edge-computing devices. By adding an attention module and mixed loss into the original VGG19 model, the method can effectively reduce the parameters of the model and increase the classification accuracy. The improved model was first trained and tested on the PC X86 GPU platform using a large dataset (COVIDx CT-2A) and a medium dataset (integrated CT scan); the weight parameters of the model were reduced by around six times compared to the original model, but it still approximately achieved 98.80%and 97.84% accuracy, outperforming most existing methods. The trained model was subsequently transferred to embedded NVIDIA Jetson devices (TX2, Nano), where it achieved 97% accuracy at a 0.6−1 FPS inference speed using the NVIDIA TensorRT engine. The experimental results demonstrate that the proposed method is practicable and convenient; it can be used on a low-cost medical edge-computing terminal. The source code is available on GitHub for researchers.
Revisiting national border effects in foreign trade in goods of Canadian provinces

ABSTRACT A significant body of empirical studies demonstrates sizable national border effects in foreign trade of Canadian provinces throughout the 1980s and 1990s. This paper revisits and expands the scope of the border effects analysis by estimating the border effect in trade with US states as well as countries in the European Union (EU) and the G-20 using more recent data from 2001–10. Furthermore, we perform the Blinder–Oaxaca nonlinear decomposition to decompose the border effects into various components, including the transaction costs, the tariff and non-tariff measures, and the unexplained component. Results from the Poisson pseudo-maximum likelihood model show that, compared to existing estimates from the 1980s and 1990s, the size of the border effect in trade between Canadian provinces and US states has declined. The border effects for Canada–EU and Canada–G-20 bilateral trade flows sit at somewhat elevated levels. About a third of the border effects in overall trade with EU and G-20 countries can be attributed to the variables related to transaction costs in foreign trade. While the significance of tariffs has declined, the prevalence of non-tariff measures seems to be on a rise. That said, we find that the welfare-changing measures combined – tariff and non-tariff measures – play a limited role in explaining the border effects in comparison with the role of transaction costs and the unexplained component.
The Relationship Between Noise-Induced Hearing Loss Awareness and the Use of Personal Listening Devices in Makkah Region, Saudi Arabia

Introduction Noise-induced hearing loss (NIHL) is one of the most common avoidable reasons for hearing impairment worldwide. Work-related, genetic, infectious, and environmental factors all have a part in defining the level of hearing impairment. Nevertheless, the use of personal listening devices (PLDs) is popular nowadays, particularly among younger people. Healthy behaviors are needed to prevent them from developing hearing loss. Our objective is to evaluate the knowledge level of NIHL among the people of Makkah, Saudi Arabia, and understand its association with PLDs. Methods A cross-sectional survey was performed in December 2022 by sending an online survey on various social media applications. An electronic Arabic questionnaire with a total of 37 questions was designed to explore the participants' demographic data, history of hearing loss, risk factors, attitudes, and awareness of NIHL. Results Almost 22% of the study had mild-to-severe hearing impairment. Hearing issues were especially common among male individuals. A higher incidence of hearing impairments was seen in individuals who were utilizing a sound degree of more than 80%. The causes for NIHL comprised exposure to occupational noise, duration of the listening session per day, and the level to which the sound of the television or the broadcasting was raised. Approximately 77% of the participants preferred to reduce the sound of their personal audio devices (PADs) to prevent NIHL. Conclusion According to this study, there is a high prevalence of hearing problems in the Saudi population. Most of the respondents understood the risk factors linked to NIHL. There is a need for more NIHL awareness campaigns to educate the Saudi population and reinforce positive, healthy listening habits.
Theory in Progress: Dyadic Power Theory: Constructing a Communication-Based Theory of Relational Power

Power is an integral part of any relationship, especially close familial relationships, because it determines how the partners relate to each other and how decisions are made. Rollins and Bahr's (1976) theory of power in marital relationships, referred to here as Dyadic Power Theory, is expanded to consider communication behavior, and to include other family dyads in addition to marriage. The theory, which emphasizes the dyadic nature of power, draws on past perspectives of power including those posited by social exchange theory, the chilling effect, sex roles, and normative resource theory. It is proposed that perceptions of legitimate authority to make decisions and access to a variety of resources increase individuals' perceptions of their own power compared to their partner. Perceptions of power, in turn, increase the likelihood of using dominant communication behavior in an attempt to control the interaction. Greater control attempts lead to greater influence over decisions. It is also predicted that perceptions of power will increase relational satisfaction for partners relatively equal in power. The propositional framework of dyadic power theory is explicated and suggestions for its use by family communication researchers are provided.
Quantification of Blood Viscoelasticity under Microcapillary Blood Flow

Blood elasticity is quantified using a single compliance model by analyzing pulsatile blood flow. However, one compliance coefficient is influenced substantially by the microfluidic system (i.e., soft microfluidic channels and flexible tubing). The novelty of the present method comes from the assessment of two distinct compliance coefficients, one for the sample and one for the microfluidic system. With two compliance coefficients, the viscoelasticity measurement can be disentangled from the influence of the measurement device. In this study, a coflowing microfluidic channel was used to estimate blood viscoelasticity. Two compliance coefficients were suggested to denote the effects of the polydimethylsiloxane (PDMS) channel and flexible tubing (C1), as well as those of the RBC (red blood cell) elasticity (C2), in a microfluidic system. On the basis of the fluidic circuit modeling technique, a governing equation for the interface in the coflowing was derived, and its analytical solution was obtained by solving the second-order differential equation. Using the analytic solution, two compliance coefficients were obtained via a nonlinear curve fitting technique. According to the experimental results, C2/C1 is estimated to be approximately 10.9–20.4 with respect to channel depth (h = 4, 10, and 20 µm). The PDMS channel depth contributed simultaneously to the increase in the two compliance coefficients, whereas the outlet tubing caused a decrease in C1. The two compliance coefficients and blood viscosity varied substantially with respect to homogeneous hardened RBCs or heterogeneous hardened RBCs. In conclusion, the proposed method can be used to effectively detect changes in blood or microfluidic systems. In future studies, the present method can contribute to the detection of subpopulations of RBCs in the patient’s blood.
Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice

Muscle atrophy is one of the main causes of sarcopenia—the age-related loss of skeletal muscle. In this study, we investigated the effect of turmeric (Curcuma longa) extract (TE) supplementation on age-related muscle atrophy in a senescence-accelerated mouse model and explored the underlying mechanisms. Twenty-six-week-old male, senescence-accelerated mouse resistant (SAMR) mice received the AIN-93G basal diet, while twenty-six-week-old male, senescence-accelerated mouse prone 8 (SAMP8) mice received the AIN-93G basal diet or a 2% TE powder-supplemented diet for ten weeks. Our findings revealed that TE supplementation showed certain effects on ameliorating the decrease in body weight, tibialis anterior weight, and mesenteric fat tissue weight in SAMP8 mice. TE improved gene expression in the glucocorticoid receptor-FoxO signaling pathway in skeletal muscle, including redd1, klf15, foxo1, murf1, and mafbx. Furthermore, TE might have the certain potential on improving the dynamic balance between anabolic and catabolic processes by inhibiting the binding of glucocorticoid receptor or FoxO1 to the glucocorticoid response element or FoxO-binding element in the MuRF1 promoter in skeletal muscle, thereby promoting muscle mass and strength, and preventing muscle atrophy and sarcopenia prevention. Moreover, TE may have reduced mitochondrial damage and maintained cell growth and division by downregulating the mRNA expression of the genes mfn2 and tsc2. Thus, the results indicated TE’s potential for preventing age-related muscle atrophy and sarcopenia.
High-Order Methods for Hypersonic Shock Wave Turbulent Boundary Layer Interaction Flow

An investigation of the accuracy of high-order methods for hypersonic shock wave turbulent boundary layer interaction (SWTBLI) is presented. The numerical methods considered here comprise of the Monotone-Upstream Central Scheme for Conservation Laws (MUSCL) and Weighted Essentially Non-Oscillatory (WENO) schemes, 2 nd to 9 th order accurate in conjunction with structured and mixed element unstructured grids. Both Implicit Large Eddy Simulation (ILES) and Reynolds Averaged Navier-Stokes (RANS) computations have been performed. The effects of discretization on the turbulence transport equation, including the approximation method for the viscous gradient, are also investigated. The accuracy of the schemes in high Reynolds number RANS modeling is assessed against experimental data of a shock impingement on a flat plate at Mach number 5 and unit Reynolds number 37×10 6 /m. ILES has been performed for the compression ramp case at moderate Reynolds numbers of 38.7×10 3 , based on the boundary layer thickness, and compared to Direct Numerical Simulations (DNS).
The geometry and topology of arithmetic hyperbolic 3-manifolds

and is called the virtual first Betti number of M. Conjecture 1.3. Let M be a closed hyperbolic 3-manifold, then vb1(M) = 1. Conjecture 1.4. Let M be a closed hyperbolic 3-manifold, then 1(M) is large; that is to say, some finite index subgroup of 1(M) admits a surjective homomorphism onto a non-abelian free group. Now it is clear that Conjecture 1.4 implies Conjecture 1.3 implies Conjecture 1.2, and standard 3-manifold topology shows that Conjecture 1.2 implies Conjecture 1.1. Our interest here is in recent work towards reversing these implications. Our geometric discussion is centered around the set of lengths of closed geodesics, as well as the set of geodesics themselves, and in particular on how these force a certain rigidity on commensurability classes. For example, the length spectrum L(M) of a hyperbolic 3-manifold M is the set of all lengths of closed geodesics on M counted with multiplicities. A question that has attracted some attention is whether hyperbolic 3-manifolds with the same length spectra are commensurable. We discuss this and other related questions in this paper.
Current trends in sustainable organization management: A bibliometric analysis

Research background: Sustainability in organizations is a business approach to creating long-term value by taking into consideration how a given organization operates in the ecological, social, and economic environments. The organizational practices that eventually lead to sustainable development are referred to as sustainable organization management. Purpose of the article: The purpose of this paper is to examine the current trends in sustainable organization management over the time period of 2015? 2022, highlight the emerging themes in this study area, and provide guidance for further research in the field. Methods: This paper uses bibliometric meta-data analysis to present an analysis of current trends in sustainable organizational management. An in-depth analysis of a sample result of 619 papers from the Web of Science core collection was conducted with the use of biblioshiny, the R-Programming Language package, and the VoS Viewer software. A global representation of concepts was created using the relational directory network visualization technique based on VoS Viewer software. Keyword cooccurrence relationships were determined; relational techniques were used to visualize bibliographic coupling density to identify thematic areas with little research; and overlay visualization bibliometric techniques were used to identify new and old research themes. Findings & value added: Emerging themes are modeling, tourism, and perceptions. Motor theme areas in the field of study include performance, impact, and management. The paper concludes that the study area of organizational sustainability management is still in its early stages and has great research potential, such as Africa as a study area, despite the fact that there have been few or no research findings. Future research should examine the role of technology and innovation in promoting sustainable practices within organizations and clarify how well an organization can survive global competition.
Modularize-and-Conquer: A Generalized Impact Dynamics and Safe Precollision Control Framework for Floating-Base Tree-Like Robots

Flexible and versatile mobile robotic coworkers are becoming an indispensable commodity for helping humans with repetitive or physically demanding work. A key challenge with these systems is respecting the strict safety requirements in shared and collaborative workspaces. This inevitably requires solving their whole-body dynamics to obtain the necessary inertial impact properties. In this article, we present an integrated impact dynamics and safe precollision control framework to address the discussed challenge. We propose a novel modular dynamics approach that provides efficient formulations for reusing the uncoupled subsystem dynamics when evaluating the coupled system. Our approach is generalized for deriving the whole-body impact dynamics of any articulated floating-base robot. Furthermore, it outperforms classical monolithic approaches for computing the dynamics, making it favorable for systems with more than two dynamic subsystems while allowing decentralized computations. Finally, based on the proposed modular and generalized impact dynamics and extending our previous work, we introduce the generalized safe motion unit as a unified safety scheme for floating-base robotic structures with branched manipulation extremities. The proposed concepts are evaluated on an exemplary wheeled mobile manipulator, considering realistic use cases in simulation and real-world experiments. The obtained results validated the efficacy of our framework and developed methods.
Non-Invasive Methods for the Prediction of Spontaneous Bacterial Peritonitis in Patients with Cirrhosis

Spontaneous bacterial peritonitis (SBP) is a potentially fatal complication in patients with liver cirrhosis. Early diagnosis and prompt treatment of SBP are vital to shorten hospital stays and reduce mortality. According to society guidelines, patients with cirrhosis and ascites who are admitted to the hospital should have diagnostic paracentesis. However, for various reasons, paracentesis may be delayed or not performed. Therefore, recent research has focused on identifying non-invasive parameters useful in SBP prediction which require urgent antibiotic therapy if rapid and secure paracentesis is not possible or there is insufficient experience with this method. In this review, we discuss the non-invasive methods available to predict SBP.
First Detection of Midlatitude Plasma Bubble by SuperDARN During a Geomagnetic Storm on May 27 and 28, 2017

We used the global navigation satellite system‐total electron content (TEC) and Super Dual Auroral Radar Network (SuperDARN) radar to elucidate the characteristics of the plasma bubble extending to midlatitudes over North America during a geomagnetic storm on 27 and 28 May 2017. To identify plasma bubbles, we analyzed the rate of the TEC index (ROTI), which is a good indicator of the occurrence of plasma bubbles. The enhanced ROTI region expanded up to 50°N (geomagnetic latitude), and the upper limit of this region coincided with the equatorward wall of the midlatitude trough. Two‐dimensional ROTI maps show that the enhanced midlatitude ROTI region moved westward at a bulk speed of approximately 310 m/s. The Fort Hays East SuperDARN radar also detected the radar echo, showing the existence of plasma density irregularities at ∼10‐m scales within the midlatitude plasma bubble. The radar echo had a westward velocity of ∼300 m/s, which is almost consistent with the westward motion of the enhanced midlatitude ROTI region. We deduced that the westward propagation of the plasma bubble could be caused by a poleward sub‐auroral polarization stream electric field. The observed radar echo overlapping with the enhanced ROTI region had a narrower spectral width (<50 m/s) than that of the auroral activity. This feature resembled that of the type 1 echo, although the Doppler velocity was smaller than the ion acoustic speed at the F‐region height. This is the first case in which plasma density irregularities within plasma bubbles were captured by the SuperDARN radar.
The Effect of Work Supervision and Implementation of 5S Work Attitudes on Employee Work Productivity

: This study aimed to determine the effect of work supervision and 5S work attitudes on employee work productivity at PT Rata Makmur Oil Palm Plantation. This study used quantitative methods involving 35 employees as research samples. The sampling technique was saturated sampling. The data collection used was a Likert-scale questionnaire. The data analysis technique used an instrument test of reliability validity and a hypothesis test using multiple linear regression analysis. This study indicates that work supervision and 5S work attitudes have a significant effect either partially or simultaneously on the employee work productivity at PT Rata Makmur Oil Palm Plantation at 59%. This means that work supervision and the 5S work attitudes are sufficient to explain their work productivity; the higher work supervision behavior and the better implementation of 5S work attitudes will increase productivity.