Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical and Psychological Outcomes of Patients Undergoing Traditional Cardiac Rehabilitation and Intensive Cardiac Rehabilitation

Change in physical and psychological outcomes of patients with eligible indications after intensive and traditional cardiac rehabilitation (CR) was compared. After completion of CR, patients in the traditional CR program had higher improvement in cardiorespiratory fitness while patients in the intensive CR program had higher improvement in anxiety and depression scores. Purpose: Both traditional cardiac rehabilitation (TCR) and intensive cardiac rehabilitation (ICR) have proven benefits for patients with cardiovascular disease. The aim of this study was to compare ICR versus TCR on cardiac rehabilitation (CR) outcomes in patients with cardiovascular disease. Methods: In a retrospective cohort study of 970 patients (n = 251, ICR; n = 719, TCR) who were referred for CR between January 2018 and December 2019, 693 (71.4%) patients completed it. The TCR sessions were 90 min (60-min exercise) three times/wk for 12 wk, while ICR sessions were 4 hr (60-min exercise) two times/wk for 9 wk. Primary endpoints were change in cardiorespiratory fitness (CRF) (by difference in exercise prescription metabolic equivalents [METs] between the last session and the average of the second and third sessions), anxiety (Generalized Anxiety Disorder-7) scores, percent depression (Patient Health Questionnaire-9 or Center for Epidemiologic Studies Depression Scale) scores, and health status (36-item Short Form Health Survey physical and mental composite scores). Linear regression adjusted for imbalanced baseline characteristics (age, race, and diagnosis of angina). Results: Of the 693 patients who completed CR (ICR = 204/251 [81%] vs TCR = 489/719 [68%], P < .01), mean age was 66 yr and 31% were female. Patients in TCR had a higher improvement in CRF (CR session METs: ICR +1.5 ± 1.2 vs TCR +1.9 ± 1.5, P < .01) but no difference in health status scores. Conversely, patients in ICR had more reduction in anxiety scores (−2 ± 4 vs −1 ± 3, P < .01) and percent reduction in depression scores (−8.3 ± 13.7% vs −5.0 ± 11.7%, P < .01) than patients in TCR. Conclusions: Patients in TCR had higher improvement in CRF while patients in ICR had higher improvement in anxiety and depression scores.
Classic and Mirabolic Robinson–Schensted–Knuth Correspondence for Partial Flags

Abstract In this paper we first generalize to the case of partial flags a result proved both by Spaltenstein and by Steinberg that relates the relative position of two complete flags and the irreducible components of the flag variety in which they lie, using the Robinson–Schensted–Knuth correspondence. Then we use this result to generalize the mirabolic Robinson–Schensted–Knuth correspondence defined by Travkin, to the case of two partial flags and a line.
The socio-economic and health effects of COVID-19 among rural and urban-slum dwellers in Ghana: A mixed methods approach

Background Vulnerable populations such as rural and urban-slum dwellers are more likely to suffer greatly from the deleterious effects of the novel Coronavirus disease 2019 (COVID-19). However, in Ghana, most COVID-19 mitigating packages are not focused on vulnerable populations. Methods Concurrent mixed methods design was used to examine the socio-economic and health effects of COVID-19 among rural and urban-slum dwellers in Ghana. Four hundred respondents were sampled for the quantitative arm of the study, while 46 In-depth Interviews (IDIs) were conducted with community members and government officials. Sixty-four community members participated in Focus Group Discussions (FGDs) and non-participant observation was carried out for three months. Quantitative data were analysed using frequencies, percentages, Pearson Chi2 and ordered logistic regression. Interviews were recorded using digital recorders and later transcribed. Transcribed data (IDIs, FGDs) and observation notes were uploaded onto a computer and transferred to qualitative software NVivo 12 to support thematic coding and analysis. Results Majority of the respondents confirmed the deleterious socio-economic and health effects of COVID-19 on jobs and prices of food. Other effects were fear of visiting a health facility even when unwell, depression and anxiety. Young people (18–32 years), males, urban-slum dwellers, married individuals, the employed and low-income earners (those who earn GHC10/$1.7 to GHC100/ $17), were more likely to suffer from the socio-economic and health effects of COVID-19. Urban-slum dwellers coped by relying on family and social networks for food and other basic necessities, while rural dwellers created locally appropriate washing aids to facilitate hand washing in the rural communities. Conclusion COVID-19 and the government’s mitigation measures had negative socio-economic and health effects on vulnerable communities. While vulnerable populations should be targeted for the government’s COVID-19 mitigating packages, special attention should be given to young people (18–32 years), males, urban-slum dwellers, married individuals and low-income earners. Communities should be encouraged to maintain coping strategies adopted even after COVID-19.
Psychosocial issues and coping mechanisms of pregnant and postnatal women diagnosed with COVID-19: A qualitative study

Objective There is a paucity of data on the psychosocial issues and coping mechanisms among pregnant and postnatal women with COVID-19 infection. We, therefore, aimed to explore the psychosocial issues and coping mechanisms of pregnant and postnatal women diagnosed with COVID-19 at tertiary-level hospitals. Methods This was a qualitative phenomenological study conducted in 2021 with a sample size of 16 women admitted at two referral hospitals serving as COVID-19 admission facilities for pregnant and postnatal women in Lusaka, Zambia. In-depth interviews were conducted via telephone to understand what these women experienced when diagnosed with COVID-19. All the interviews were audio-recorded and transcribed verbatim. Thematic analysis was conducted using the six steps approach to develop emerging themes. Results Two major themes emerged: psychosocial issues and coping mechanisms. The primary psychosocial issues were worry and stigma. Women worried about infecting their unborn baby or neonate, being separated from the baby, the general safety of the baby, and the health of other family members. Women also worried about the attitude of health care providers and faced discrimination or stigma because of their infection. Thus, some coping mechanisms were developed that helped them, such as a positive attitude, keeping the disease secret, reliance on family members for support and using positive information from social media. Conclusion This study provides unique insights into the psychosocial experiences of pregnant and postnatal women diagnosed with COVID-19. Women were particularly concerned about the unborn baby’s well-being and discrimination. This study suggests the need for policy and clinical practice to consider the integration of effective mental health services into the provision of maternal health and COVID-19 services.
Closely Coupled Fluid-Solid Interface Method with Moving-Average for LES based Conjugate Heat Transfer Solution

Fluid–solid coupled Conjugate Heat Transfer (CHT) simulations are relevant to many practical problems. Most existing interfacing methods have been developed for Reynolds averaged Navier-Stokes solvers. For high fidelity turbulence scale-resolved flow solvers however, the CHT interface methods face significant challenges arisen from a wide frequency spectrum of unsteady disturbances to be dealt with, compounded by the huge time scale disparity between fluid and solid domains. In this paper, a closely coupled non-partitioned (monolithic) CHT method is presented. The main issues of interest are the prohibitive time costs of direct time domain CHT methods and an extra mesh dependency in the solid domain when resolving high frequency turbulence disturbances. Based on a temporal Fourier spectral framework, the present CHT interface method entails a moving-average for the time-mean flow and a discrete Fourier transform on-the-fly at each time step. Taking advantage of a semi-analytical transfer function and harmonic balancing for the CHT interface, we can achieve solving the solid domain completely in its own time step (3-5 orders of magnitude larger than that of the fluid domain). The present interface method can effectively circumvent aliasing errors and extra solid domain mesh-dependence encountered by other time-domain coupling methods when applied to turbulence scale-resolved CHT solutions. Illustrative stability analyses also show that the numerical stability of the present CHT interface should require no more stringent conditions than that in either fluid or solid domain. The computational results and analyses highlight the advantages of the present methodology in terms of both the computational efficiency and accuracy, in comparison with a conventional directly coupled interface method. Furthermore, a case study aided by a simple interface response analysis highlights much augmented wall temperature fluctuations and higher sensitivity to the interface treatment when a low conductivity protection layer (Thermal Barrier Coating, TBC) is added. The present study underlines the relevance of accounting for fluid disturbances over a range of frequencies in an effective and accurate CHT interface treatment.
CLINICAL SIGNIFICANCE OF ULTRASONIC PLACENTAL GRADING DURING THIRD TRIMESTER IN HYPERTENSIVE DISORDERS OF PREGNANCY AND ITS CORRELATION WITH FETAL OUTCOME Significance of Ultrasonic Placental Grading during Third Trimester in Hypertensive Disorders and its

: INTRODUCTION : Pre-eclampsia is a common (7% of all pregnancies) disorder in which normal haemodynamic response is compromised. Pre-eclampsia is an important cause of maternal and fetal morbidity and mortality. Inspite of its relevant epidemiological impact, the complete pathogenesis of this disease still remains an enigma underlining a multifactorial aetiology. AIMS AND OBJECTIVES: To study the placental grading by USG in pregnancy complicated by hypertensive disorders and compare the fetal outcome parameters like mode of delivery, fetal distress, birth asphyxia, fetal maturity and perinatal mortality and morbidity in relation to placental grading. MATERIALS AND METHODS: This study was conducted for a period of 2 years. Data was collected from 200 patients attending the Department of OBG in Vani Vilas Hospital attached to Bangalore Medical College and Research institute. It Included 100 pregnant women with Pre eclampsia and 100 normotensive women as controls. Ultrasound placental grading was done and the placental grading was correlated with fetal outcome. RESULTS : Majority of the patients were in the age group of 20-25 years (70%), with a mean age of 20.92 years in the control group and 20.88 in the study group. In the control group 33%, 50%, and 17% women had placental grading of I, II and III respectively as against 18%, 56% and 26% in the women in the study group. Preterm delivery was significantly more in the study group (24%). Spontaneous delivery was 87% in controls versus 59% in the study group. Induced delivery was 8% amongst controls and 21% in study group. Caesarean was 25% in study group and 5% in controls. Foetal distress was more in the study group. Perinatal mortality was 12% in study group versus 3% in the controls. Grade III placenta in the study group showed a perinatal mortality of 7% versus 0% in the controls. CONCLUSION: Foetal complications were significantly more in the study group compared to controls. Placental grading did not show significant correlations with perinatal outcomes except for the small for gestation babies. The study concludes that there is no significant correlation of placental grading with perinatal outcomes.
by Calpains Proteolytic Regulation of Activated STAT6

The transcription factor STAT6 plays an important role in cell responses to IL-4. Its activation is tightly regulated. STAT6 phosphorylation is associated with JAKs, whereas dephosphorylation is associated with speciﬁc phosphatases. Several studies indicate that proteases can also regulate STAT6. The aim of this study was to investigate the nature of these proteases in mouse T cell lines. We found that STAT6 was degraded in cell extracts by calcium-dependent proteases. This degradation was speciﬁcally prevented by calpain inhibitors, suggesting that STAT6 was a target for these proteases. This was supported by the cleavage of STAT6 by recombinant calpains. The proteolytic regulation of STAT6 was more complex in vivo. Calcium signaling was not sufﬁcient to induce STAT6 degradation. However, treatment of IL-4-stimulated cells with calcium ionophores resulted in the absence of phosphorylated STAT6. This effect correlated with the loss of STAT6 protein and was prevented by calpain inhibitors. Cytoplasmic calpains seemed to be responsible for STAT6 degradation. Calpains can target signaling proteins; in this study we found that they can negatively regulate activated STAT6. The Journal of Immunology, 2005, 174: 2843–2848.
Risk factors of pressure ulcers among traumatized patients

Critically ill patients are at a higher risk for pressure ulcers than patients in general care unites. Several factors increase the risk: severity of illness; increased length of stay; poor tissue perfusion due to hemodynamic instability, use of vasoactive medications, anemia; sensory impairment, skin maceration due to moisture; immobility; and poor nutritional status. Aim: the aim of this study is to assess the risk factors of pressure ulcers among traumatized patients. Design: descriptive research design was used to conduct this research. Setting: this study was carried out at Trauma ICU at Assiut University Hospitals . Subjects: sample of this study included 60 adult patients. Tools: two tools were used for data collection in this study . Results: The main results revealed that most of study sample aged between 41- 60 years old, and there was a significant difference between the age groups. Results also indicated a significant difference between the studied samples in relation to the different risk factors. There was a significance difference in the studied patients in relation to the temperature. As regard the Braden scale assessment, it was found a significance difference between the studied patients in relation to the sub items of the scale. Conclusion: proper assessment of the patients for pressure ulcer risk factors is very important for prevention.
AN ASSESSMENT OF SERUM FIBRINOGEN LEVELS IN PATIENT OF ACUTE STROKE

: Objective: To assess the serum fibrinogen levels in patient of stroke presenting at BVH Bahawalpur. Material and methods: This cross-sectional study was conducted at Department of Pathology, Quaid-e-Azam Medical College/BVH, Bahawalpur from September 2018 to March 2019 over the period of 6 months. Total 50 patients with first-ever stroke admitted within 24 h after stroke onset either male or female were selected for this study. Serum fibrinogen levels were assessed in selected patients. Results: A total of 50 patients of stroke were enrolled and studied. Thirty (60%) cases reported ischemic stroke while hemorrhagic stroke was observed in 20 (40%) cases. Thirteen out of 50 (26%) patients were in the age group of 31-40 years; with age distribution of rest of the participants being relatively evenly distributed. Males (29, 58%) outnumbered females (21, 42%). Conclusion: In conclusion, we report significantly higher than normal mean fibrinogen levels in ischemic and hemorrhagic stroke and fibrinogen levels increased with increasing infarct volume and the correlation between infarct volume and fibrinogen levels being significant in ischemic stroke. In both the groups, the fibrinogen levels in patients who died was insignificantly higher as compared to patients who survived. Limited mortality numbers probably didn’t allow the observations of present study to reach the level of significance, which prompts us to recommend similar study with higher numbers.
STUDENT VIEWS OF TECHNOLOGY-MEDIATED WRITTEN CORRECTIVE FEEDBACK

This article reports on the preliminary findings of an investigation of student beliefs, attitudes, and practices in relation to written corrective feedback in the context of the teaching of English in lower-secondary education in Denmark. The study is related to an intervention study carried out in three 8th-grades involving three teachers, introducing technology as the mediating tool for feedback. Results show a positive perceived impact of the intervention among the students.
An Evaluation of the Three Pillars of Sustainability in Cities with High Airbnb Presence: A Case Study of the City of Madrid

: The recent proliferation of private tourist accommodations on what has been known as sharing economy has induced new models on urban tourism and on the use of traditional housing. Urban tourism pressure has caused many transformation processes with important impacts in neighborhoods with high tourist interest, which are shown in the evolution of certain urban sustainability indicators, such as those proposed by the UN-Habitat Agenda for Sustainable Cities in line with the principles of the Leipzig Charter on Sustainable European Cities. Due to the above, the objective of this work is to analyze the spatial distribution of Airbnb accommodations, and explore the factors associated with the situation of Airbnb rentals in relation to the indicators of urban sustainability of neighborhoods and variables related to the gentriﬁcation processes of neighborhoods in which there is crowding or overtourism, measured through the Global Tourist Stress Index. For this, a ﬁrst-order spatial autoregressive panel (SAR) data model with ﬁxed effects has been speciﬁed, the results of which provide us with information to understand how sustainability indicators in the neighborhoods of the city of Madrid in the time period 2015–2018, they would explain the location and number of Airbnb accommodations found there. Additionally, it allows us to observe the existence of a spillover effect from the central neighborhoods, with a high per capita income, to nearby neighborhoods with lower income due to the level of tourist crowding, which is a contribution to the scarce existing literature. relationship between the increase in noise and urban waste in neighborhood “i” and the number of Airbnb accommodations in neighborhood bordering “j”. Hypothesis 6d (H6d). Positive relationship between the increase in the ISGT index in the neighborhood “i” and the number of Airbnb accommodations in neighborhood borderline “j”.
Higher Solar Irradiance Is Associated With a Lower Incidence of Coronavirus Disease 2019

We studied the relationship between the incidence of coronavirus disease 2019 (COVID-19), demographical, and climatological measurements in different regions across the world. Lower solar irradiance and higher population density were independent predictors of greater COVID-19 outbreaks. Further studies on the potential protective effect of sunlight over COVID-19 are warranted.
Parsing the Role of Nox Enzymes and ROS in Heart Failure

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COLORECTAL CANCER AWARENESS AMONG PUBLIC POPULATION IN EASTERN PROVINCE, SAUDI ARABIA

Introduction: Colorectal cancer is the second most spread cancer in females and the third in males worldwide [1]. In Saudi Arabia, it was reported in 2014, that new colorectal cancer patients are 11.5% of the total cancer patients; making it the second most common cancer among Saudis [2]. According to multiple studies done in Saudi Arabia, the public awareness of colorectal cancer diagnosis and prevention is low, with varying levels from region to another, and from age group to another [3,4]. Aim: The goal of this study is to identify the level of awareness of colorectal cancer among public population in the Eastern Province of Saudi Arabia. Methodology: This study is a “Cross Sectional Study” based on a questionnaire done through Google’s Survey, distributed via social media. The questionnaire consisted of 20 questions (7 personal and 13 speciﬁed to knowledge of colorectal cancer). The study population was 963 participants out of the general population of Saudi Arabia Eastern Province. Results, Conclusion and Recommendations: Only 19.4% of the participants think that colorectal cancer is widespread in Saudi Arabia. Of the participants, only 7.4% knew the correct risk factors of this cancer, only 8.3% knew the screening tests, while 87.94% thought that colon cancer is avoidable. In conclusion, the population of Saudi Arabia Eastern Province need annual campaigns for education about colorectal cancer. Therefore, the population of Eastern Province, Saudi Arabia is in need for educational campaigns about colorectal cancer.
ANALYSIS OF MEROZOITE SURFACE PROTEIN-3Β IN PLASMODIUM VIVAX ISOLATES COLLECTED FROM SOUTHWESTERN COASTAL REGION OF INDIA

Background: Malaria is one of the major infectious diseases and is a global health threat. Malarial parasites exhibit high genetic diversity, Which is one of the reasons hampering the vaccine development. Analysis of genetic variations in known vaccine candidates is crucial for developing an effective vaccine. The current study was aimed at analysing one of the members of the merozoite surface family of proteins, MSP- 3β, of Plasmodium vivax ( Pv ) in parasite samples collected from patients from southwestern coastal region of India, where prevalence of P. vivax predominates compared to P. falciparum. Method: A total of 25 field isolates were analysed in the study. Allelic diversity at the Plasmodium vivax merozoite surface protein-3β locus was investigated using a combined polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) procedure. Results: PCR products of Pv MSP-3β revealed three allelic variants. Digestion with Pst 1 restriction enzyme yielded suballelic variants. A total of five different alleles were observed in the current study. Conclusion: Even though the samples were limited, Pv MSP-3β was found to be significantly variant in the isolates from this area. Further studies using substantially more samples would provide definitive information about the extent of polymorphisms in P. vivax isolates in this area.
SURVEY AND SUMMARY Counting the ions surrounding nucleic acids

Nucleic acids are strongly negatively charged, and thus electrostatic interactions––screened by ions in solution––play an important role in governing their ability to fold and participate in biomolecular interactions. The negative charge creates a region, known as the ion atmosphere, in which cation and anion concentrations are perturbed from their bulk values. Ion counting experiments quantify the ion atmosphere by measuring the preferential ion interaction coefﬁcient: the net total number of excess ions above, or below, the number expected due to the bulk concentration. The results of such studies provide important constraints on theories, which typically predict the full three-dimensional distribution of the screening cloud. This article reviews the state of nucleic acid ion counting measurements and critically analyzes their ability to test both analytical and simulation-based models.