Miracle-dz/UniFAR-FTUs huggingface dataset:
A Multifaceted Intervention to Improve Medication Adherence in Kidney Transplant Recipients: An Exploratory Analysis of the Fidelity of the TAKE IT Trial

Background Inadequate adherence to prescribed immunosuppressive medication regimens among kidney transplant recipients is common, yet interventions are needed to support patients in sustaining adequate adherence to prescribed regimens and achieving optimal transplant outcomes. Objective We examined the preliminary fidelity of a transplant center-based, multifaceted adherence monitoring strategy known as TAKE IT. Methods The TAKE IT strategy includes: (1) routine, online, monthly patient self-report adherence assessments; (2) care alerts directed to nurses; (3) quarterly reports monitoring tacrolimus values and adherence trends; (4) support tools tailored to specific adherence concerns. A 2-arm, patient-randomized trial is underway at two large transplant centers (N=449). To evaluate the initial fidelity of TAKE IT, we investigated patient uptake of monthly adherence assessments during the course of a 3-month period, whether any disparities emerged, and the nature of any reported adherence concerns. Results Among 202 patients randomized and exposed to TAKE IT for 3-months or more, 81% (164/202) completed an adherence assessment, 73% (148/202) completed at least two, and 57% (116/202) completed all monthly assessments. Overall, 50% (82/164) of kidney transplant recipients reported at least one adherence concern over the 3-month assessment period. The most common barriers were classified as regimen-related (eg, regimen complexity), cognitive (eg, forgetfulness), and medical (eg, side effects). Higher-income participants were more likely to complete all surveys compared to lower-income participants (P=.01). Conclusions TAKE IT demonstrated 81% (164/202) completion of an adherence assessment, 73% (148/202) completion of at least two, and 57% (116/202) completion of all monthly assessments during this brief, initial observation period. Among those that did respond to the online assessments, the majority demonstrated sustained engagement. Additional monitoring modalities could also be offered to meet patient preferences to ensure all patients’ medication use can be properly monitored. Trial Registration ClinicalTrials.gov NCT03104868; https://clinicaltrials.gov/ct2/show/NCT03104868
Non-invasive brain microcurrent stimulation therapy of long-COVID-19 reduces vascular dysregulation and improves visual and cognitive impairment

Background: An effective treatment is needed for long-COVID patients which suffer from symptoms of vision and/or cognition impairment such as impaired attention, memory, language comprehension, or fatigue. Objective: Because COVID-19infection causes reduced blood flow which may cause neuronal inactivation, we explored if neuromodulation with non-invasive brain stimulation using microcurrent (NIBS), known to enhance blood flow and neuronal synchronization, can reduce these symptoms. Methods: Two female long-COVID patients were treated for 10–13 days with alternating current stimulation of the eyes and brain. While one patient (age 40) was infected with the SARS CoV-2 virus, the other (age 72) developed symptoms following AstraZeneca vaccination. Before and after therapy, cognition was assessed subjectively by interview and visual fields quantified using perimetry. One patient was also tested with a cognitive test battery and with a retinal dynamic vascular analyser (DVA), a surrogate marker of vascular dysregulation in the brain. Results: In both patients NIBS markedly improved cognition and partially reversed visual field loss within 3–4 days. Cognitive tests in one patient confirmed recovery of up to 40–60% in cognitive subfunctions with perimetry results showing stable and visual field recovery even during follow-up. DVA showed that NIBS reduced vascular dysregulation by normalizing vessel dynamics (dilation/constriction), with particularly noticeable changes in the peripheral veins and arteries. Conclusions: NIBS was effective in improving visual and cognitive deficits in two confirmed SARS-COV-2 patients. Because recovery of function was associated with restoration of vascular autoregulation, we propose that (i) hypometabolic, “silent” neurons are the likely biological cause of long-COVID associated visual and cognitive deficits, and (ii) reoxygenation of these “silent” neurons provides the basis for neural reactivation and neurological recovery. Controlled trials are now needed to confirm these observations.
Effects of mutual coupling in conical horn arrays

The paper considers the copolar and crosspolar radiation patterns of a finite array of conical horn elements in which full account is taken of the effects of mutual coupling. Mutual coupling between, respectively, the TE11- and TE21-, and the TE11- and TM01-modes has a marked effect on copolar pattern symmetry and on the level of crosspolarisation. Contour plots are given for `clean-beam? excitation of the arrays, and the influence of horn aperture size is shown to be significant.
A comparison of supply chain vulnerability indices for different categories of firms

Given the high vulnerability of today's supply chains to disruptions, measuring and managing supply chain vulnerability has become critical. In the attempt to support practice in reducing supply chain vulnerability, we (1) discuss and define the concept of supply chain vulnerability and (2) measure and compare supply chain vulnerability for various categories of firms. Normal Accident Theory and High Reliability Theory provide the theoretical foundations for the empirical study, and graph modelling is the method used to construct a measure for supply chain vulnerability. The empirical data largely confirm that there is a negative relationship between supply chain vulnerability and supply chain performance, a positive relationship between structural categories (firm size and production type) and supply chain vulnerability, and a positive relationship between supply chain vulnerability and managerial categories (logistics importance, supply chain risk planning, and supply chain risk management).
Intervención grupal de promoción de hábitos saludables en el ámbito laboral: Programa IPHASAL

Introduction: Cardiovascular disease is a major public health problem. The workplace is an optimal setting to intervene on cardiovascular risk factors. The aim is to evaluate a group intervention to promote healthy habits (IPHASAL program) through peer support in the workplace. Method: The program involved 325 workers in 13 companies with cardiovascular risk factors (hypertension, smoking, overweight, physical inactivity). Before and after the program, weight and height, blood pressure were measured and a questionnaire on health habits was administered. The program consisted of training workshops and group sessions in which participants shared experiences, knowledge and progress on healthy habits. The outcome was measured with the Fuster BEWAT Index (FBI), calculated with the score of 5 variables under study: blood pressure, exercise, weight, diet and smoking. Results: Participants without exclusion criteria in the project were 273. 79% attended 3 or more workshops and 73.9% attended 3 or more sessions. All FBI parameters improved significantly after the program, with the largest increase in physical activity and the smallest increase in smoking. Total FBI increased by 17.4% (1.5 points), with a higher increase in women (19.6%) than in men (14.0%) and in the youngest group (21.6%). Conclusions: The IPHASAL group program is applicable to the workplace and contributes to improving the cardiovascular risk profile, helping workers to promote change towards healthy lifestyles.
Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms

Intracranial aneurysms are pathological dilatations of intracranial arteries and prevail in around 3.2% of the general population. The worst outcome of an aneurysm is its rupture. Its prevention and management can be accomplished by two broad modalities: surgical clipping and endovascular coiling. This review has explored each of these approaches individually and has then directly compared them to provide a good understanding of their respective advantages and disadvantages over one another. Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course. The risks and benefits of each of these procedures must be thoroughly examined in each case. This article has stressed the need to consider all contributing patient, procedure-related, surgeon-related, and hospital factors before arriving at a final decision to manage a specific case.
2005 Bernard M. Gordon Prize Lecture * : Integrating Engineering Education and Community Service: Themes for the Future of Engineering Education

On February 20, 2005, the National Academy of Engineering recognized the achievements of the Engineering Projects in Community Service (EPICS) program with the Bernard M. Gordon Prize for Innovation in Engineering and Technology Education. As its founders and directors, we were commended “For innovations in the education of tomorrow’s engineering leaders by developing and disseminating the Engineering Projects in Community Service (EPICS) program. ” We are very proud that our program has been honored with this prestigious award. We hope the attention it focuses on the program highlights the ways that long-term, for-credit projects in the community provide the time and context for experiences that enable our students to: ● develop technical depth and multi-disciplinary breadth; ● experience start-to-finish design; ● acquire and hone many professional skills; ● create products that have a significant impact on their community; and ● grow as individuals, engineers, and citizens. These benefits of EPICS were outcomes that the engineering education community was seeking in the early 1990s [1–4]. We believe integrating time and context into other aspects of the curriculum will lead to further innovations that provide outcomes that the engineering education community seeks for the coming decades [5, 6]. II. OVERVIEW OF EPICS
Alternation emerges as a multi-modal strategy for turbulent odor navigation

Foraging mammals exhibit a familiar yet poorly characterized phenomenon, “alternation”, a momentary pause to sniff in the air often preceded by the animal rearing on its hind legs or raising its head. Intriguingly, rodents executing an olfactory search task spontaneously exhibit alternation in the presence of airflow, suggesting that alternation may serve an important role during turbulent plume-tracking. To test this hypothesis, we combine fully-resolved numerical simulations of turbulent odor transport and Bellman optimization methods for decision-making under partial observability. We show that an agent trained to minimize search time in a realistic odor plume exhibits extensive alternation together with the characteristic cast-and-surge behavior commonly observed in flying insects. Alternation is tightly linked with casting and occurs more frequently when the agent is far downwind of the source, where the likelihood of detecting airborne cues is higher relative to cues close to the ground. Casting and alternation emerge as complementary tools for effective exploration when cues are sparse. We develop a model based on marginal value theory to capture the interplay between casting, surging and alternation. More generally, we show how multiple sensorimotor modalities can be fruitfully integrated during complex goal-directed behavior.
Ultimate Strength of R.C. Wall Panels in Two‐Way In‐Plane Action

Test results of 24 reinforced concrete wall panels in two-way action (i.e., supported on all the four sides) and subjected to in-plane vertical load are presented. The load is applied at an eccentricity to represent possible accidental eccentricity that occurs in practice due to constructional imperfections. Influences of aspect ratio, thinness ratio, slendemess ratio, vertical steel, and horizontal steel on the ultimate load are studied. Two equations are proposed to predict the ultimate load carried by the panels. The first equation is empirical and is arrived at from trial and error fitting with test data. The second equation is semi-empirical and is developed from a modification of the buckling strength of thin rectangular plates. Both the equations are formulated so as to give a safe prediction of a large portion of ultimate strength test results. Also, ultimate load cracking load and lateral deflections of identical panels in two-way action (all four sides supported) and oneway action (top and bottom sides only supported) are compared.
Carbon Ion Fluxes at Mars: First Results of Tailward Flows From MAVEN‐STATIC

Characterizing C+ ions in the Martian ionosphere is important for understanding the history of the Martian atmosphere and surface due to its place in understanding carbon escape. Measuring minor ions, like C+, which are close in mass to major atmospheric ions, in this case O+, is difficult, requiring fitting algorithms and accurate background subtraction. Accurate measurement of these species is essential for understanding chemistry and transport in the ionosphere. In this paper, we use data from the Mars Atmospheric and Volatile EvolutioN SupraThermal And Thermal Ion Composition (MAVEN‐STATIC) sensor to report the first C+ fluxes measured in the Martian magnetotail. We will describe a multistep method of background subtraction as well as fitting routines that are used to extract C+ fluxes from a 40‐orbit subset of STATIC data. Our results show tailward fluxes in both optical shadow and the adjacent sunlit magnetotail at high altitudes ( > $ > $ 3,000 km) and Mars‐ward at low altitudes ( < $< $ 2,000 km) in shadow. These local flux values are similar to estimates of neutral carbon fluxes from photochemical escape. However, total carbon loss comparisons will require a more comprehensive study of integrated C+ loss over a larger data set from the Martian magnetotail.
Impact of Long-Term Cyclamate and Saccharin Consumption on Biochemical Parameters in Healthy Individuals and Type 2 Diabetes Mellitus Patients

Background: Previous studies on saccharin and cyclamate were either limited to experimental animals or lacked evaluation of their long-term consumption effects in humans. Objectives: This study evaluated the effect of chronic consumption of saccharin and cyclamate on biochemical parameters in healthy individuals and patients with type 2 diabetes mellitus. Material and Methods: Healthy and diabetic individuals were classified into two groups based on whether they consumed sweeteners or not. The participants were classified according to the amount of sweetener consumed per day and duration of consumption. Serum catalase activity, peroxynitrite, ceruloplasmin, and malondialdehyde concentrations were determined. Glycated hemoglobin, fasting glucose, creatinine, alanine transaminase, and lipid profile were also evaluated. The results suggest that saccharin and cyclamate increased HbA1C (+11.16%), MDA (+52.38%), TG (+16.74%), LDL (+13.39%), and TC/HDL (+13.11%) in healthy volunteers. Diabetic patients consuming sweeteners showed increased FSG (+17.51%), ceruloplasmin (+13.17%), and MDA (+8.92%). Diabetic patients showed a positive correlation between the number of tablets consumed per day with FSG and serum creatinine. A positive correlation was found between the duration of sweetener consumption and FSG as well as TG. Conclusion: Consumption of saccharin and cyclamate affected biochemical parameters related to metabolic functions in a time and dose-dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients.
Interrelationships between latent state-trait theory and generalizability theory within a structural equation modeling framework.

Over recent years, latent state-trait theory (LST) and generalizability theory (GT) have been applied to a wide variety of situations in numerous disciplines to enhance understanding of the reliability and validity of assessment data. Both methodologies involve partitioning of observed score variation into systematic and measurement error components. LST theory is focused on separating state, trait, error, and sometimes method effects, whereas generalizability theory is concerned with distinguishing universe score effects from multiple sources of measurement error. Despite these fundamental differences in focus, LST and GT share much in common. In this article, we use data from a widely used personality measure to illustrate similarities and differences between these two frameworks and show how the same data can be readily interpreted from both perspectives. We also provide comprehensive instructional online supplemental materials to demonstrate how to analyze data using the R package for all LST models and GT designs discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Single-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study

PURPOSE Mosunetuzumab is a bispecific antibody targeting CD20 and CD3 that redirects T cells to engage and eliminate malignant B cells and is being developed for relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). METHODS This first-in-human trial (ClinicalTrials.gov identifier: NCT02500407) evaluated the safety and tolerability and efficacy of mosunetuzumab in patients with R/R B-NHL and established the recommended phase II dose. Data from dose escalation are presented. Single-agent mosunetuzumab was administered intravenously in 3-week cycles, at full dose in cycle 1 day 1 (group A) or with ascending (step-up) doses during cycle 1 on days 1, 8, and 15 (group B), for eight or 17 cycles on the basis of tumor response. RESULTS Two hundred thirty patients were enrolled. Doses up to 2.8 mg and 60 mg were assessed in groups A and B, respectively; maximum tolerated dose was not exceeded. In group B (n = 197), common adverse events (≥ 20% of patients) were neutropenia (28.4%), cytokine release syndrome (27.4%), hypophosphatemia (23.4%), fatigue (22.8%), and diarrhea (21.8%). Cytokine release syndrome was mostly low-grade (grade ≥ 3: 1.0%) and mainly confined to cycle 1. Across the doses investigated (group B), best overall response rates were 34.9% and 66.2% in patients with aggressive and indolent B-NHL, respectively, and complete response rates were 19.4% and 48.5%. Among patients with a complete response, the median duration of response was 22.8 months (95% CI, 7.6 to not estimable) and 20.4 (95% CI, 16 to not estimable) in patients with aggressive and indolent B-NHL, respectively. CONCLUSION Mosunetuzumab, administered with step-up dosing, has a manageable safety profile and induces durable complete responses in R/R B-NHL. The expansion stage of the study is ongoing at the dose level of 1/2/60/60/30 mg selected for further study.
A Brief Review of Measuring Techniques for Characterization of Dielectric Materials

The Dielectric property of material has gain significance in industrial application in recent decade. These properties provide useful information to improve the design, processing, quality and control of product. Among various techniques, to opt an appropriate method it is required to consider various factors. In this paper main characteristic of these properties followed by brief introduction of measuring technique is presented. In later part, a comparative analysis of important techniques is outlined.
Molecular diagnosis of dermatophyte isolates from canine and feline dermatophytosis in Northeast Iran

Abstract Background Dermatophytes are the most common causes of cutaneous fungal diseases. Dermatophytosis is a common skin disorder in dogs and cats. Species identification of these fungi is important from a therapeutic and epidemiological aspect. Conventional methods used to identify dermatophyte species are often lengthy and may be inefficient in many circumstances. Recently broad varieties of several molecular DNA‐based techniques were successfully utilised for species detection of dermatophytes. Objectives The aim of this study was to determine the molecular detection of dermatophyte isolates from canine and feline dermatophytosis in Mashhad, Iran. Methods Thirty dermatophytes isolated from dogs and cats with skin lesions and one standard strain of Microsporum canis were cultured onto Mycosel agar, and then internal transcribed spacer (ITS) region of the ribosomal DNA was amplified using the universal fungal primers ITS1 and ITS4. PCR products were subjected to sequencing and sequence analysis. Results Based on the sequencing of the ITS1‐5.8S‐ITS2 region on all samples, all the studied strains were M. canis and their sexual stage (teleomorph) was Arthroderma otae. Conclusions Microsporum canis was the only species found among dogs and cats, and its high prevalence can increase the rate of transmission to humans. In practice, ITS‐PCR, with sequence analysis, is a useful and reliable method to identify and differentiate various pathogenic species, and it can be used in clinical and epidemiological fields, even for the rapid diagnosis of dermatophyte species that are closely interrelated.
Describing Situation Awareness at an Emergency Medical Dispatch Centre

In this paper we describe findings on Situation Awareness (SA) from a field study on decision making in ambulance control, or Emergency Medical Dispatch (EMD). Triangulating the results from observations and Contextual Inquiry interviews of 18 participants, with 13 Critical Decision Methods in-depth interviews, we found, among other things, that EMD work can be classified as routine operations, start of a major incident, and when an incident is established. Higher levels of SA were exhibited by dispatchers for non-routine or major incidents, than for routine events. Senior dispatchers, or allocators, developed a “picture in the head” of the situation, and used that to plan ahead and to evaluate their plans. They were also found to use an information hub strategy to develop and maintain their SA. Using a combined Wickens (2000) and Endsley (1995) framework, we see allocators interleaving their attention and information handling between routine and major incidents.
MULTI-OBJECTIVE EFFICIENT DESIGN OF NP CONTROL CHART USING DATA ENVELOPMENT ANALYSIS

Control charts are the most important tools of statistical process control used to discriminate between assignable and common causes of variation and to improve the quality of a process. To design a control chart, three parameters including sample size, sampling interval, and control limits should be determined. The objectives are hourly expected cost, in-control average run length, power of the control chart, and average time to signal. Different approaches such as statistical design, economic design, and economic-statistical design of control charts have been considered by many researchers. Recently, multi-objective design of control chart has been investigated in the literature. In this paper we propose a multi-objective economic-statistical design of np control chart (np-MOESD). To solve the multi-objective model, a method is used to find the Pareto optimal solution and then a combined method based on Data Envelopment Analysis (DEA) is proposed to determine the most efficient design parameters. A numerical example of Duncan [1] illustrates the proposed approach. Sensitivity analysis is performed to evaluate the proposed model. In addition, the proposed model is compared with pure economic design (Duncan’s model) as well as another model in the literature. Results show that the proposed np-MOESD model improves statistical properties of np control charts.