Miracle-dz/UniFAR-FTUs huggingface dataset:
INVESTIGATION OF SCUFFING RESISTANCE AND TRIBOLOGICAL PERFORMANCE OF LASER MODIFIED SURFACES

Latest development in high-power lasers made possible a wide variety of laser surface modifications. Such surface modifications include: glazing, shock peening, alloying, cladding and texturing. The main reason behind applying these treatments is to improve the tribological performance of the modified surfaces. In addition to reducing friction and wear, it is favorable to improve the scuffing resistance. Scuffing can be defined as a sudden catastrophic failure of a lubricated sliding surface characterized by a sudden rise in friction; resulting in severe surface damage through localized plastic flow. This paper investigates friction and scuffing performance of laser glazed 1080 steel and laser textured H13 stainless steel. Results showed that laser glazed surfaces reduced sliding friction under dry conditions by approximately 35% and improved wear resistance. In addition, laser glazed surfaces showed high resistance to scuffing compared to unglazed surfaces. Also, laser surface texturing technique reduced sliding friction under lubricated conditions and improved scuffing resistance.Copyright © 2005 by ASME
Prevention of secondary caries by a new antibacterial compound

Background: Since secondary caries is one of the main problems of dental composites. The creation of an antibacterial property in these composites is essential. The objective of this study was to synthesize 3-(2, 5-dimethylfuran-3-yl)-1H-pyrazole-5(4H)-one and check its biocompatibility and antibacterial properties in flowable dental composites. Materials and Methods: In this animal study, the antibacterial activity of flowable resin composites containing 0–5 wt% 3-(2,5-dimethylfuran-3-yl)-1H-pyrazole-5(4H)-one was investigated by using agar diffusion and direct contact tests on the cured resins. Statistical analysis was performed using one-way ANOVA test (P < 0.001). Thirty male albino Wistar rats were used, weighing 200–250 g. Animals were randomly divided into three groups of ten; each animal received three implants, 3-(2, 5-dimethylfuran-3-yl)-1H-pyrazole-5(4H)-one, penicillin V, and an empty polyethylene tube. A pathologist, without knowing the type of material tested and the timing of the test, examined the samples. Statistical analysis was performed using Kruskal–Wallis test (P < 0.001). Results: According to our findings, although the agar diffusion test reveals no significant difference between the groups, the direct contact test demonstrates that, by increasing the 3-(2,5-dimethylfuran-3-yl)-1H-pyrazole-5(4H)-one content, the bacterial growth was significantly diminished and the 3-(2,5-dimethylfuran-3-yl)-1H-pyrazole-5(4H)-one has a good biocompatibility (P < 0.05). Conclusion: Incorporation of 3-(2,5-dimethylfuran-3-yl)-IH-pyrazole-5(4H)-one into flowable resin composites can be useful to prevent Streptococcus mutans activity.
Monetary Policy and the Adjustment of Belgian private bank interest rates- An econometric analysis

In this paper, we analyze the pass-through of market rates to micro retail interest rates for a basket of different types of loans and deposits using a panel of 37 Belgian banks over the January 2003September 2006 period. We find that Belgian banks adjust relatively rapidly their interest rates to changes in the market rates, but that their reaction is only partial. In addition, we find significant heterogeneity across sectors, products and banks. & Research Department, National Bank of Belgium $ Corresponding author, Research Department, National Bank of Belgium, e-mail: Marianne.Collin@nbb.be ± Research Department, National Bank of Belgium, Centre de Recherche Waroqué, Université de Mons-Hainaut * The views expressed in this paper are those of the authors and do not necessarily reflect the views of the National Bank of Belgium.
Feasibility and outcome of community-based screening for cardiovascular disease risk factors in a remote rural area of South India: The Chunampet rural–Cardiovascular health assessment and management program

Background: As committed by India in Global Action Plan, Sustainable Development Goals and National Health Policy 2017, India has the responsibility to provide accessible, affordable noncommunicable disease care to the people. Our study aimed to find out the burden of cardiovascular risk factors among hypertension and diabetic patients, through a community-based screening, in a remote rural area of South India. Methods: A special program named “Chunampet Rural–Cardiovascular Health Assessment and Management Program” (CR-CHAMP) was launched in August and September 2017 in a Rural Health Training Center (RHTC), functioning under a private medical college in South India. In this program, participants with hypertension (HT) and diabetes (DM) were line listed from 10 remote villages, and then history, initial biochemical, hormonal, and hematological screenings were done to assess the cardiovascular diseases (CVDs) risk factors among these patients, following which special consultation was offered in RHTC. Results: Out of 415 eligible patients with HT and DM, 389 were approached; among them, 328 were willing to participate and were screened initially; among them, 235 were attended special consultation. Higher CVD risk was found in 21%. Prevalence of chronic kidney disease was 14%, deranged lipid profile was more than 50%, metabolic syndrome was 49%, anemia was 68%, abnormal waist-hip ratio was 56%, abdominal obesity was 59%, and overweight and obesity using body mass index (BMI) was 59%. Females' participation was more in our community-based screening procedure (66%) than male participation (34%). Conclusion: CR-CHAMP demonstrated feasibility and value of implementing a screening program for high-risk individuals with HT and DM for CVD risk through existing primary care in a remote rural area of South India. This will help the National Program and policymakers to plan for interventions in the remote rural area in future.
Guanylate-Binding Protein 1: An Emerging Target in Inflammation and Cancer

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression is strongly provoked by interferon γ (IFNγ) and acts to restrain cellular proliferation in inflammatory contexts. In immunity, GBP1 activity is crucial for the maturation of autophagosomes infected by intracellular pathogens and the cellular response to pathogen-associated molecular patterns. In chronic inflammation, GBP1 activity inhibits endothelial cell proliferation even as it protects from IFNγ-induced apoptosis. A similar inhibition of proliferation has also been found in some tumor models, such as colorectal or prostate carcinoma mouse models. However, this activity appears to be context-dependent, as in other cancers, such as oral squamous cell carcinoma and ovarian cancer, GBP1 activity appears to anchor a complex, taxane chemotherapy resistance profile where its expression levels correlate with worsened prognosis in patients. This discrepancy in GBP1 function may be resolved by GBP1's involvement in the induction of a cellular senescence phenotype, wherein anti-proliferative signals coincide with potent resistance to apoptosis and set the stage for dysregulated proliferative mechanisms present in growing cancers to hijack GBP1 as a pro- chemotherapy treatment resistance (TXR) and pro-survival factor even in the face of continued cytotoxic treatment. While the structure of GBP1 has been extensively characterized, its roles in inflammation, TXR, senescence, and other biological functions remain under-investigated, although initial findings suggest that GBP1 is a compelling target for therapeutic intervention in a variety of conditions ranging from chronic inflammatory disorders to cancer.
THE SENSITIVITY OF THERMALLY DRIVEN MOUNTAIN FLOWS TO LAND COVER CHANGE by

The influence of heterogeneous land cover on the boundary layer and surface conditions was examined in the mountainous, semi-arid Wasatch Front region of northern Utah. In addition, sensitivity studies were conducted to evaluate the effect of land cover change on surface temperatures and on the depth of the convective boundary layer. Using the Pennsylvania State University/National Center for Atmospheric Research fifth-generation Mesoscale Model, the Great Salt Lake and Utah Lake were found to play a dominant role in modulating the depth of the convective boundary layer, while areas of urban and agricultural land cover exerted local effects. Subsidence arising from slope flows and a crossvalley circulation were not found to have a large impact on the boundary layer in this case. In order to simulate the conditions that existed prior to large-scale human habitation, a simulation was conducted in which all anthropogenic land cover types (e.g., urban, residential, agricultural) in the initial simulation, termed the 1992 run, were changed to grassland. This was termed 1847 run. Compared to the 1847 run, the convective boundary layer in the 1992 run was deeper over urban land and shallower over irrigated cropland. In addition, the lake breeze front was faster to arrive in the urbanized area of the Salt Lake Valley, but slower to move past. This was a result of the convergent circulation over the locally warm urban area. It is hypothesized that as urban land increasingly replaces agricultural land in semi-arid regions, local temperature and convective boundary layer depth anomalies, as well as non-local effects on the lake breeze, will have more dramatic effects than the urbanization of natural land cover.
로스팅 온도에 따른 쥐눈이콩(Rhynchosia nulubilis)의 성분 분석 및 항산화 활성

This study was conducted to determine the optimal roasting temperature (90, 100, 110, and 120; fixed time of 20 minutes) of small black coffee beans under various roasting conditions. The roasting temperature range and fixed time were the same as our preceding study. After roasting, the general composition, isoflavone contents, and antioxidant activities were measured. As the results of the proximate composition analysis of small black beans according to roasting conditions, only moisture decreased among them, whereas other general compositions were not affected. The DPPH and ABTS radical scavenging activities were the highest at a roasting temperature of 120°C. Total polyphenol and total flavonoid contents were also highest at 120°C. Isoflavone contents showed a positive correlation with DPPH and ABTS radical scavenging activities, as well as total phenol and flavonoid contents. These results suggest that the optimal roasting conditions of small black beans were determined to be 120°C for 20 minutes.
FACTORS DETERMINING TAXPAYERS’ PERCEPTION TOWARDS TAX FAIRNESS: THE STRUCTURAL EQUATION MODEL FOR TURKEY

Tax noncompliance is a significant problem that should be researched given changing tax views of taxes. Tax compliance is a complex issue and can be explained by both economic and social factors. Perceptions of fairness have played an important role in taxpayers’ voluntary tax compliance. This exploratory study investigated the relationship between tax compliance and fairness from the point of view of taxpayers’ perception of tax fairness and the factors determining tax fairness. Using survey data collected from 481 taxpayers, this relationship was found using a structural equation model with Turkey as the sample country. We found that perceived fairness in the tax system depends on the structure of the tax system, interaction with the tax administration, inefficiency in the tax system, tax morale and the using of public expenditures
UPLC-Q-TOF-MS Study of the Mechanism of THSWD for Breast Cancer Treatment

Taohong Siwu decoction (THSWD) is a classic traditional Chinese medicine (TCM) prescription that is widely used in the clinical treatment of gynecological and cerebrovascular diseases. Here we used a method that coupled ultra-performance liquid chromatography to quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) in which both positive and negative ion modes were established to investigate the major constituents in THSWD. A Waters ACQUITY UPLC BEH C18 column (2.1 mm×100 mm, 1.7 μm) was used to separate the aqueous extract of THSWD. The mobile phase consisted of 0.1% aqueous formic acid (A) and acetonitrile (B). Ninety-five components were identified in two different ion modes, including aromatic acids, flavones, polysaccharides, volatile oils monoterpene glycosides, aromatic cyanogenic glycosides, and others. Pathological changes in tumors and serum expression of interleukin-4 in a mouse model of breast cancer were detected after THSWD treatment. The results showed that THSWD had obvious therapeutic effects. This study establishes a material basis for the use of THSWD in the treatment of breast cancer.
Revised slip rates for the Alpine fault at Inchbonnie: Implications for plate boundary kinematics of South Island, New Zealand

The northeast-striking, dextral-reverse Alpine fault transitions into the Marlborough Fault System near Inchbonnie in the central South Island, New Zealand. New slip-rate estimates for the Alpine fault are presented following a reassessment of the geomorphology and age of displaced late Holocene alluvial surfaces of the Taramakau River at Inchbonnie. Progressive avulsion and abandonment of the Taramakau floodplain, aided by fault movements during the late Holocene, have preserved a left-stepping fault scarp that grows in height to the northeast. Surveyed dextral (22.5 ± 2 m) and vertical (4.8 ± 0.5 m) displacements across a left stepover in the fault across an alluvial surface are combined with a precise maximum age from a remnant tree stump (≥1590–1730 yr) to yield dextral, vertical, and reverse-slip rates of 13.6 ± 1.8, 2.9 ± 0.4, and 3.4 ± 0.6 mm/yr, respectively. These values are larger (dextral) and smaller (dip slip) than previous estimates for this site, but they reflect advances in the local chronology of surfaces and represent improved time-averaged results over 1.7 k.y. A geological kinematic circuit constructed for the central South Island demonstrates that (1) 69%–89% of the Australian-Pacific plate motion is accommodated by the major faults (Alpine-Hope-Kakapo) in this transitional area, (2) the 50% drop in slip rate on the Alpine fault between Hokitika and Inchbonnie is taken up by the Hope and Kakapo faults at the southwestern edge of the Marlborough Fault System, and (3) the new slip rates are more compatible with contemporary models of strain partitioning presented from geodesy.
Convergence of Inflammatory Pathways in Allergic Asthma and Sickle Cell Disease

The underlying pathologies of sickle cell disease and asthma share many characteristics in terms of respiratory inflammation. The principal mechanisms of pulmonary inflammation are largely distinct, but activation of common pathways downstream of the initial inflammatory triggers may lead to exacerbation of both disease states. The altered inflammatory landscape of these respiratory pathologies can differentially impact respiratory pathogen susceptibility in patients with sickle cell disease and asthma. How these two distinct diseases behave in a comorbid setting can further exacerbate pulmonary complications associated with both disease states and impact susceptibility to respiratory infection. This review will provide a concise overview of how asthma distinctly affects individuals with sickle cell disease and how pulmonary physiology and inflammation are impacted during comorbidity.
Preclinical Activity of JNJ-7957, a Novel BCMA×CD3 Bispecific Antibody for the Treatment of Multiple Myeloma, Is Potentiated by Daratumumab

Purpose: Multiple myeloma (MM) patients with disease refractory to all available drugs have a poor outcome, indicating the need for new agents with novel mechanisms of action. Experimental Design: We evaluated the anti-MM activity of the fully human BCMA×CD3 bispecific antibody JNJ-7957 in cell lines and bone marrow (BM) samples. The impact of several tumor- and host-related factors on sensitivity to JNJ-7957 therapy was also evaluated. Results: We show that JNJ-7957 has potent activity against 4 MM cell lines, against tumor cells in 48 of 49 BM samples obtained from MM patients, and in 5 of 6 BM samples obtained from primary plasma cell leukemia patients. JNJ-7957 activity was significantly enhanced in patients with prior daratumumab treatment, which was partially due to enhanced killing capacity of daratumumab-exposed effector cells. BCMA expression did not affect activity of JNJ-7957. High T-cell frequencies and high effector:target ratios were associated with improved JNJ-7957–mediated lysis of MM cells. The PD-1/PD-L1 axis had a modest negative impact on JNJ-7957 activity against tumor cells from daratumumab-naïve MM patients. Soluble BCMA impaired the ability of JNJ-7957 to kill MM cells, although higher concentrations were able to overcome this negative effect. Conclusions: JNJ-7957 effectively kills MM cells ex vivo, including those from heavily pretreated MM patients, whereby several components of the immunosuppressive BM microenvironment had only modest effects on its killing capacity. Our findings support the ongoing trial with JNJ-7957 as single agent and provide the preclinical rationale for evaluating JNJ-7957 in combination with daratumumab in MM.
Equity Option Pricing with Systematic and Idiosyncratic Volatility and Jump Risks

Recently, a large number of empirical studies indicated that individual equity options exhibit a strong factor structure. In this paper, the importance of systematic and idiosyncratic volatility and jump risks on individual equity option pricing is analyzed. First, we propose a new factor structure model for pricing the individual equity options with stochastic volatility and jumps, which takes into account four types of risks, i.e., the systematic diffusion, the idiosyncratic diffusion, the systematic jump, and the idiosyncratic jump. Second, we derive the closed-form solutions for the prices of both the market index and individual equity options by utilizing the Fourier inversion. Finally, empirical studies are carried out to show the superiority of our model based on the S&P 500 index and the stock of Apple Inc. on options. The out-of-sample pricing performance of our proposed model outperforms the other three benchmark models especially for short term and deep out-of-the-money options.
The effect of task and ego orientation to athletic identity and anti social behavior of students and athletes

The present study examined the affect of task and ego orientation on athletic identity and anti social behavior of students and athletes. A total of 156 students (86 males and 70 females with a mean age of 16,5 years) and 150 athletes (90 males and 60 females with a mean age of 18,5 years) participated at the study. The study was conducted from December 2012 to February 2013 during a basketball school tournament at the premises of Anatolia College for students and during local championships for athletes. TEOSQ (The Task and Ego Orientation in Sport Questionnaire) by Nicholls (1989) was used for the assessment of goals, the A.I.M.S. (Athletic Identity Measurement Scale) by Brewer et al,(1993 ) for athletic identity and the questionnaire by M.Kavussanu (pro-social and antisocial behavior 2006) was used for antisocial behaviour. All questionnaires have been previously used for similar studies in Greece. Results showed that task and ego orientation as well as identity affect antisocial behavior. Differences among athletes and students were observed only on athletic identity, while regarding the two sexes boys showed higher scores on antisocial behavior and aggression in relation to girls.
SELF-PROPELLED INTERACTING PARTICLE SYSTEMS WITH ROOSTING FORCE

We consider a self-propelled interacting particle system for the collective behavior of swarms of animals, and extend it with an attraction term called roosting force, as it has been suggested in Ref. 30. This new force models the tendency of birds to overfly a fixed preferred location, e.g. a nest or a food source. We include roosting to the existing individual-based model and consider the associated mean-field and hydrodynamic equations. The resulting equations are investigated analytically looking at different asymptotic limits of the corresponding stochastic model. In addition to existing patterns like single mills, the inclusion of roosting yields new scenarios of collective behavior, which we study numerically on the microscopic as well as on the hydrodynamic level.
Synergistic Approach of Ultrafast Spectroscopy and Molecular Simulations in the Characterization of Intramolecular Charge Transfer in Push-Pull Molecules

The comprehensive characterization of Intramolecular Charge Transfer (ICT) stemming in push-pull molecules with a delocalized π-system of electrons is noteworthy for a bespoke design of organic materials, spanning widespread applications from photovoltaics to nanomedicine imaging devices. Photo-induced ICT is characterized by structural reorganizations, which allows the molecule to adapt to the new electronic density distribution. Herein, we discuss recent photophysical advances combined with recent progresses in the computational chemistry of photoactive molecular ensembles. We focus the discussion on femtosecond Transient Absorption Spectroscopy (TAS) enabling us to follow the transition from a Locally Excited (LE) state to the ICT and to understand how the environment polarity influences radiative and non-radiative decay mechanisms. In many cases, the charge transfer transition is accompanied by structural rearrangements, such as the twisting or molecule planarization. The possibility of an accurate prediction of the charge-transfer occurring in complex molecules and molecular materials represents an enormous advantage in guiding new molecular and materials design. We briefly report on recent advances in ultrafast multidimensional spectroscopy, in particular, Two-Dimensional Electronic Spectroscopy (2DES), in unraveling the ICT nature of push-pull molecular systems. A theoretical description at the atomistic level of photo-induced molecular transitions can predict with reasonable accuracy the properties of photoactive molecules. In this framework, the review includes a discussion on the advances from simulation and modeling, which have provided, over the years, significant information on photoexcitation, emission, charge-transport, and decay pathways. Density Functional Theory (DFT) coupled with the Time-Dependent (TD) framework can describe electronic properties and dynamics for a limited system size. More recently, Machine Learning (ML) or deep learning approaches, as well as free-energy simulations containing excited state potentials, can speed up the calculations with transferable accuracy to more complex molecules with extended system size. A perspective on combining ultrafast spectroscopy with molecular simulations is foreseen for optimizing the design of photoactive compounds with tunable properties.